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Search of human proteins with 74229013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74229013 2',5'-oligoadenylate synthetase 1 isoform 1 [Homo
sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74229013 2',5'-oligoadenylate synthetase 1 isoform 1 [Homo sa... 835 0.0
gi|74229015 2',5'-oligoadenylate synthetase 1 isoform 3 [Homo sa... 720 0.0
gi|74229011 2',5'-oligoadenylate synthetase 1 isoform 2 [Homo sa... 719 0.0
gi|45007007 2'-5'oligoadenylate synthetase 3 [Homo sapiens] 389 e-108
gi|74229017 2'-5'-oligoadenylate synthetase 2 isoform 2 [Homo sa... 368 e-102
gi|74229019 2'-5'-oligoadenylate synthetase 2 isoform 1 [Homo sa... 368 e-102
gi|11321577 2'-5'-oligoadenylate synthetase-like isoform a [Homo... 240 1e-63
gi|38016930 2'-5'-oligoadenylate synthetase-like isoform b [Homo... 131 9e-31
gi|74229021 2'-5'-oligoadenylate synthetase 2 isoform 3 [Homo sa... 73 4e-13
gi|24234747 interleukin enhancer binding factor 2 [Homo sapiens] 31 1.7
gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 30 5.0
gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s... 30 5.0
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 29 8.6
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 29 8.6
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 29 8.6
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 29 8.6
gi|189458898 postmeiotic segregation 1 isoform c [Homo sapiens] 29 8.6
gi|189458896 postmeiotic segregation 1 isoform b [Homo sapiens] 29 8.6
gi|4505911 postmeiotic segregation 1 isoform a [Homo sapiens] 29 8.6
gi|62750354 matrin 3 [Homo sapiens] 29 8.6
gi|21626466 matrin 3 [Homo sapiens] 29 8.6
>gi|74229013 2',5'-oligoadenylate synthetase 1 isoform 1 [Homo
sapiens]
Length = 400
Score = 835 bits (2156), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
Sbjct: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
Query: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
Sbjct: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
Query: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
Sbjct: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
Query: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
Sbjct: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
Query: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
Sbjct: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
Query: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPR 360
PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPR
Sbjct: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPR 360
Query: 361 RYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL 400
RYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
Sbjct: 361 RYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL 400
>gi|74229015 2',5'-oligoadenylate synthetase 1 isoform 3 [Homo
sapiens]
Length = 414
Score = 720 bits (1858), Expect = 0.0
Identities = 346/348 (99%), Positives = 347/348 (99%)
Query: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
Sbjct: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
Query: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
Sbjct: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
Query: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
Sbjct: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
Query: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
Sbjct: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
Query: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
Sbjct: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
Query: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAE 348
PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL +
Sbjct: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLTQ 348
>gi|74229011 2',5'-oligoadenylate synthetase 1 isoform 2 [Homo
sapiens]
Length = 364
Score = 719 bits (1856), Expect = 0.0
Identities = 346/346 (100%), Positives = 346/346 (100%)
Query: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK
Sbjct: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK 60
Query: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE
Sbjct: 61 GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFE 120
Query: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL
Sbjct: 121 VQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDL 180
Query: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW
Sbjct: 181 QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAW 240
Query: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD
Sbjct: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
Query: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL 346
PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL
Sbjct: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL 346
>gi|45007007 2'-5'oligoadenylate synthetase 3 [Homo sapiens]
Length = 1087
Score = 389 bits (999), Expect = e-108
Identities = 206/344 (59%), Positives = 243/344 (70%), Gaps = 13/344 (3%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L TPA LDKFI ++L P+ F Q+N A+D IC FLKE CFR S P+ V KVVKGGS
Sbjct: 747 LYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNS--PIKVIKVVKGGS 804
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
S KGT LRGRSDADLVVFLS + F +Q N+R E I EIR QLEACQ+ER F VKFEV
Sbjct: 805 SAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVS- 863
Query: 124 PRWGNPRALSFVLSS-LQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQK 182
+W NPR LSF L+S L + V+FDVLPAFDALGQL G +P+ Q+YV LI ++
Sbjct: 864 -KWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNA-- 920
Query: 183 EGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNC---KKKLGKLPPQYALELLTVYA 239
GE+STCFTELQRDF+ RPTKLKSLIRLVKHWYQ C K G LPPQ+ LELLTVYA
Sbjct: 921 -GEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYA 979
Query: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVIL 299
WE+G + FN A+GFRTVLELV Y+QLCIYWT Y+ K+ + +L++QL KPRP+IL
Sbjct: 980 WEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIIL 1039
Query: 300 DPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
DPADPTGNLG W LA+EA A + C +G P+ W
Sbjct: 1040 DPADPTGNLGHN--ARWDLLAKEAAACTSALCCMGRNGIPIQPW 1081
Score = 295 bits (754), Expect = 6e-80
Identities = 165/349 (47%), Positives = 216/349 (61%), Gaps = 21/349 (6%)
Query: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
+DL P K LD+FI+D+L P F+ Q+ AIDII L E C +S +V KG
Sbjct: 406 LDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKAS------RVSKG 459
Query: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
GS G+GT LR D +L++FL+ T ++DQ RR E + E+R QLE+ +++ S+ +
Sbjct: 460 GSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLS--L 517
Query: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
Q P P AL F L S L + +LPAFDA+GQL+ G KPNPQ+Y +L+ T
Sbjct: 518 QFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLL---TSGC 574
Query: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK------LPPQYALEL 234
+EGE CF EL+R+F+ RP KLK+LI LVKHWY Q + GK LPP YALEL
Sbjct: 575 QEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALEL 634
Query: 235 LTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKP 294
LT++AWE+G + FN AQGFRTVL LV +QQLC+YWT Y ++P + +L QL KP
Sbjct: 635 LTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKP 694
Query: 295 RPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
RP++LDPADPT N+G G W LAQEA A CF + DG+ V W
Sbjct: 695 RPLVLDPADPTWNVGHG---SWELLAQEAAALGMQACFLSRDGTSVQPW 740
Score = 283 bits (724), Expect = 2e-76
Identities = 155/345 (44%), Positives = 214/345 (62%), Gaps = 8/345 (2%)
Query: 2 MDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKG 61
MDL +TPA +LD+F+ L P F + A+ + L+ER R + V K VKG
Sbjct: 1 MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG 60
Query: 62 GSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEV 121
GSSG+GT L+G D++LV+FL ++ DQ RR E + E+R LE+ + ++
Sbjct: 61 GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF 120
Query: 122 QAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQ 181
P P AL F L+S+ L + ++ ++PAF+ LGQ G KP PQ+Y L+
Sbjct: 121 --PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGC--- 175
Query: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWY-QNCKKKLGK--LPPQYALELLTVY 238
+ GE + CFTEL+R+F+ RP KLK+LI LVKHWY Q C + L K LPP YALELLT++
Sbjct: 176 QGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIF 235
Query: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
AWE+G K F+ A+G RTVL L+ +Q LC++WT Y F++P + ++L+RQL +PRPVI
Sbjct: 236 AWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVI 295
Query: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
LDPADPT +LG G W LAQEA + ++PCF G PV SW
Sbjct: 296 LDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSW 340
>gi|74229017 2'-5'-oligoadenylate synthetase 2 isoform 2 [Homo
sapiens]
Length = 687
Score = 368 bits (945), Expect = e-102
Identities = 186/345 (53%), Positives = 246/345 (71%), Gaps = 9/345 (2%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L TP LDKFI+++L P+ CF QI+ A++II FLKE CFR S+ + ++V+GGS
Sbjct: 340 LFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKI---QIVRGGS 396
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
+ KGT L+ SDADLVVF + L ++ Q N R + ++EI QL+A RE+ ++ +
Sbjct: 397 TAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEP 456
Query: 124 PRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIE--ECTDLQ 181
P+W PR LSF L S L E V FDVLPAF+ALGQL+ G P+P++Y LI+ + +DL
Sbjct: 457 PKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLP 516
Query: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKL---GKLPPQYALELLTVY 238
GEFSTCFT LQR+F++ RPTKLK LIRLVKHWY+ C++KL G LPP+YALELLT+Y
Sbjct: 517 G-GEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIY 575
Query: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
AWE+GS F+TA+GFRTVLELV YQQLCI+W Y+F++ + K+L QL K RPVI
Sbjct: 576 AWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVI 635
Query: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
LDPA+PTG++GGGD W LA+EA+ WL+ PCFK+ G+P+ W
Sbjct: 636 LDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPW 680
Score = 229 bits (585), Expect = 3e-60
Identities = 141/346 (40%), Positives = 190/346 (54%), Gaps = 20/346 (5%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L + PA+ L FI++YL P + I+ ++ IC L+E +P+ V V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP----EQFPL-VQGVAIGGS 62
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
G+ T LRG SD LV+F S L FQDQ + + + + +L+ C + FE+Q
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQK 122
Query: 124 PRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKE 183
G F + + + F+VL AF+AL P+P IY +L
Sbjct: 123 SLDG------FTIQVFTKNQRISFEVLAAFNALSL---NDNPSPWIYRELKRSLDKTNAS 173
Query: 184 -GEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPP--QYALELLTVYAW 240
GEF+ CFTELQ+ F RP KLK LI L+KHW+Q C+KK+ LP YALELLTVYAW
Sbjct: 174 PGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAW 233
Query: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
E+G K +F+ A+G RTVLEL+ ++LCIYW Y+F++ I L QL RPVILD
Sbjct: 234 EQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILD 293
Query: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL 346
P DPT N+ GD W+ L +EA+ WL P N P SW +L
Sbjct: 294 PVDPTNNV-SGDKICWQWLKKEAQTWLTSPNLDN--ELPAPSWNVL 336
>gi|74229019 2'-5'-oligoadenylate synthetase 2 isoform 1 [Homo
sapiens]
Length = 719
Score = 368 bits (945), Expect = e-102
Identities = 186/345 (53%), Positives = 246/345 (71%), Gaps = 9/345 (2%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L TP LDKFI+++L P+ CF QI+ A++II FLKE CFR S+ + ++V+GGS
Sbjct: 340 LFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKI---QIVRGGS 396
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
+ KGT L+ SDADLVVF + L ++ Q N R + ++EI QL+A RE+ ++ +
Sbjct: 397 TAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEP 456
Query: 124 PRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIE--ECTDLQ 181
P+W PR LSF L S L E V FDVLPAF+ALGQL+ G P+P++Y LI+ + +DL
Sbjct: 457 PKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLP 516
Query: 182 KEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKL---GKLPPQYALELLTVY 238
GEFSTCFT LQR+F++ RPTKLK LIRLVKHWY+ C++KL G LPP+YALELLT+Y
Sbjct: 517 G-GEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIY 575
Query: 239 AWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVI 298
AWE+GS F+TA+GFRTVLELV YQQLCI+W Y+F++ + K+L QL K RPVI
Sbjct: 576 AWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVI 635
Query: 299 LDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
LDPA+PTG++GGGD W LA+EA+ WL+ PCFK+ G+P+ W
Sbjct: 636 LDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPW 680
Score = 229 bits (585), Expect = 3e-60
Identities = 141/346 (40%), Positives = 190/346 (54%), Gaps = 20/346 (5%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L + PA+ L FI++YL P + I+ ++ IC L+E +P+ V V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP----EQFPL-VQGVAIGGS 62
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
G+ T LRG SD LV+F S L FQDQ + + + + +L+ C + FE+Q
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQK 122
Query: 124 PRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKE 183
G F + + + F+VL AF+AL P+P IY +L
Sbjct: 123 SLDG------FTIQVFTKNQRISFEVLAAFNALSL---NDNPSPWIYRELKRSLDKTNAS 173
Query: 184 -GEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPP--QYALELLTVYAW 240
GEF+ CFTELQ+ F RP KLK LI L+KHW+Q C+KK+ LP YALELLTVYAW
Sbjct: 174 PGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAW 233
Query: 241 ERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD 300
E+G K +F+ A+G RTVLEL+ ++LCIYW Y+F++ I L QL RPVILD
Sbjct: 234 EQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILD 293
Query: 301 PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILL 346
P DPT N+ GD W+ L +EA+ WL P N P SW +L
Sbjct: 294 PVDPTNNV-SGDKICWQWLKKEAQTWLTSPNLDN--ELPAPSWNVL 336
>gi|11321577 2'-5'-oligoadenylate synthetase-like isoform a [Homo
sapiens]
Length = 514
Score = 240 bits (613), Expect = 1e-63
Identities = 141/350 (40%), Positives = 198/350 (56%), Gaps = 14/350 (4%)
Query: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCF---RGSSYPVCVSK 57
M +L +TPA LD F+ +L P ++ ++ A+ + FL++ F RG V V K
Sbjct: 4 MQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLK 63
Query: 58 VVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSV 117
VVK GS G GT LR + +LV FLS +FQ+ + ++ I + + Q + +
Sbjct: 64 VVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTM--WQSQDLLDL 121
Query: 118 KFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEEC 177
E P AL F + + E + ++PA+ ALG +P P++YV LI+ C
Sbjct: 122 GLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKAC 181
Query: 178 TDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQN---CKKKLGKLPPQYALEL 234
G F F+ELQR+F+K RPTKLKSL+RLVKHWYQ + LPP YALEL
Sbjct: 182 GG---PGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALEL 238
Query: 235 LTVYAWERGSMKT-HFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTK 293
LT+YAWE G+ + +F +GF TV++L++ Y+ +CIYWTKYY N IIE +R+QL K
Sbjct: 239 LTIYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKK 298
Query: 294 PRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSW 343
RP+ILDPADPT N+ G W +AQ A L C + +P+SSW
Sbjct: 299 ERPIILDPADPTLNVAEG--YRWDIVAQRASQCLKQDCCYDNRENPISSW 346
>gi|38016930 2'-5'-oligoadenylate synthetase-like isoform b [Homo
sapiens]
Length = 255
Score = 131 bits (330), Expect = 9e-31
Identities = 81/220 (36%), Positives = 118/220 (53%), Gaps = 8/220 (3%)
Query: 1 MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCF---RGSSYPVCVSK 57
M +L +TPA LD F+ +L P ++ ++ A+ + FL++ F RG V V K
Sbjct: 4 MQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVRVLK 63
Query: 58 VVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSV 117
VVK GS G GT LR + +LV FLS +FQ+ + ++ I + + Q + +
Sbjct: 64 VVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTM--WQSQDLLDL 121
Query: 118 KFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEEC 177
E P AL F + + E + ++PA+ ALG +P P++YV LI+ C
Sbjct: 122 GLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKAC 181
Query: 178 TDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQ 217
G F F+ELQR+F+K RPTKLKSL+RLVKHWYQ
Sbjct: 182 GG---PGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQ 218
>gi|74229021 2'-5'-oligoadenylate synthetase 2 isoform 3 [Homo
sapiens]
Length = 172
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/155 (32%), Positives = 77/155 (49%), Gaps = 11/155 (7%)
Query: 4 LRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGS 63
L + PA+ L FI++YL P + I+ ++ IC L+E +P+ V V GGS
Sbjct: 8 LSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEP----EQFPL-VQGVAIGGS 62
Query: 64 SGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQA 123
G+ T LRG SD LV+F S L FQDQ + + + + +L+ C + FE+Q
Sbjct: 63 YGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQK 122
Query: 124 PRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQ 158
G F + + + F+VL AF+AL +
Sbjct: 123 SLDG------FTIQVFTKNQRISFEVLAAFNALSK 151
>gi|24234747 interleukin enhancer binding factor 2 [Homo sapiens]
Length = 390
Score = 31.2 bits (69), Expect = 1.7
Identities = 22/86 (25%), Positives = 38/86 (44%)
Query: 20 LLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLV 79
L P++ + I + I + ++ V + +V + GS KGT G + ADLV
Sbjct: 64 LAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLV 123
Query: 80 VFLSPLTTFQDQLNRRGEFIQEIRRQ 105
V L L T + + ++ +R Q
Sbjct: 124 VILKILPTLEAVAALGNKVVESLRAQ 149
>gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 29.6 bits (65), Expect = 5.0
Identities = 47/196 (23%), Positives = 72/196 (36%), Gaps = 32/196 (16%)
Query: 181 QKEGEFSTCFTELQRDFLKQRPTKL-KSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYA 239
+ E + TE + L + PTK K+ LV W +K GK P E
Sbjct: 703 ETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGK-PSDGLSERPLRIT 761
Query: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYY-DFKNPIIEKYLRRQLTKPRPVI 298
+ + T N+ G + Y K+Y F +P + + RR+
Sbjct: 762 TDPEVLATQLNSLPG--------LTYSPHVYSTPKHYIRFTSPFLSEKRRRK-------- 805
Query: 299 LDPADPTGNLGGGDPKGWRQLAQEAE-----AWLNYPCFKNWDGSPVS----SWILLAES 349
+PT N+ G K W + A E E N PC + V+ S +LL +S
Sbjct: 806 ----EPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDS 861
Query: 350 NSADDETDDPRRYQKY 365
S D T ++ + Y
Sbjct: 862 CSLPDLTTPLKKRRFY 877
>gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
Length = 1858
Score = 29.6 bits (65), Expect = 5.0
Identities = 47/196 (23%), Positives = 72/196 (36%), Gaps = 32/196 (16%)
Query: 181 QKEGEFSTCFTELQRDFLKQRPTKL-KSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYA 239
+ E + TE + L + PTK K+ LV W +K GK P E
Sbjct: 703 ETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLSEKNEKTGK-PSDGLSERPLRIT 761
Query: 240 WERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYY-DFKNPIIEKYLRRQLTKPRPVI 298
+ + T N+ G + Y K+Y F +P + + RR+
Sbjct: 762 TDPEVLATQLNSLPG--------LTYSPHVYSTPKHYIRFTSPFLSEKRRRK-------- 805
Query: 299 LDPADPTGNLGGGDPKGWRQLAQEAE-----AWLNYPCFKNWDGSPVS----SWILLAES 349
+PT N+ G K W + A E E N PC + V+ S +LL +S
Sbjct: 806 ----EPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPLLLNDS 861
Query: 350 NSADDETDDPRRYQKY 365
S D T ++ + Y
Sbjct: 862 CSLPDLTTPLKKRRFY 877
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 28.9 bits (63), Expect = 8.6
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 9/50 (18%)
Query: 201 RPTKLKSLIRLVKHWYQNCK----KKLGKLPPQYALELLTVYAWERGSMK 246
RP++++ L L + W + CK + L + P +EL WE+GS K
Sbjct: 1378 RPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL-----WEKGSKK 1422
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 28.9 bits (63), Expect = 8.6
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 9/50 (18%)
Query: 201 RPTKLKSLIRLVKHWYQNCK----KKLGKLPPQYALELLTVYAWERGSMK 246
RP++++ L L + W + CK + L + P +EL WE+GS K
Sbjct: 1348 RPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL-----WEKGSKK 1392
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 28.9 bits (63), Expect = 8.6
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 9/50 (18%)
Query: 201 RPTKLKSLIRLVKHWYQNCK----KKLGKLPPQYALELLTVYAWERGSMK 246
RP++++ L L + W + CK + L + P +EL WE+GS K
Sbjct: 1392 RPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL-----WEKGSKK 1436
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 28.9 bits (63), Expect = 8.6
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 9/50 (18%)
Query: 201 RPTKLKSLIRLVKHWYQNCK----KKLGKLPPQYALELLTVYAWERGSMK 246
RP++++ L L + W + CK + L + P +EL WE+GS K
Sbjct: 1422 RPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL-----WEKGSKK 1466
>gi|189458898 postmeiotic segregation 1 isoform c [Homo sapiens]
Length = 770
Score = 28.9 bits (63), Expect = 8.6
Identities = 12/39 (30%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 197 FLKQRPTKLKSLIRLVKHWYQ-NCKKKLGKLPPQYALEL 234
F+ RP K +++L++H Y C K+ +L P + L++
Sbjct: 261 FINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKI 299
>gi|189458896 postmeiotic segregation 1 isoform b [Homo sapiens]
Length = 893
Score = 28.9 bits (63), Expect = 8.6
Identities = 12/39 (30%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 197 FLKQRPTKLKSLIRLVKHWYQ-NCKKKLGKLPPQYALEL 234
F+ RP K +++L++H Y C K+ +L P + L++
Sbjct: 222 FINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKI 260
>gi|4505911 postmeiotic segregation 1 isoform a [Homo sapiens]
Length = 932
Score = 28.9 bits (63), Expect = 8.6
Identities = 12/39 (30%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 197 FLKQRPTKLKSLIRLVKHWYQ-NCKKKLGKLPPQYALEL 234
F+ RP K +++L++H Y C K+ +L P + L++
Sbjct: 261 FINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKI 299
>gi|62750354 matrin 3 [Homo sapiens]
Length = 847
Score = 28.9 bits (63), Expect = 8.6
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 248 HFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGN 307
H N A R L+ Y + W D + + + ++ +Q T P P IL P P+ +
Sbjct: 309 HINGASHSRRCQLLLEIYPE----WNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFH 364
Query: 308 LGG 310
LGG
Sbjct: 365 LGG 367
>gi|21626466 matrin 3 [Homo sapiens]
Length = 847
Score = 28.9 bits (63), Expect = 8.6
Identities = 19/63 (30%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 248 HFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGN 307
H N A R L+ Y + W D + + + ++ +Q T P P IL P P+ +
Sbjct: 309 HINGASHSRRCQLLLEIYPE----WNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFH 364
Query: 308 LGG 310
LGG
Sbjct: 365 LGG 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,905,424
Number of Sequences: 37866
Number of extensions: 805221
Number of successful extensions: 1851
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1799
Number of HSP's gapped (non-prelim): 25
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.