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Search of human proteins with 73486649
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
(214 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 433 e-122
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 315 2e-86
gi|73486651 membrane-spanning 4-domains, subfamily A, member 3 i... 182 2e-46
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 91 1e-18
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 91 1e-18
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 90 1e-18
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 90 1e-18
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 89 3e-18
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 71 6e-13
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 69 2e-12
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 68 5e-12
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 68 5e-12
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 67 1e-11
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 66 3e-11
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 60 1e-09
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 60 2e-09
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 60 2e-09
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 58 5e-09
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 58 5e-09
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 58 5e-09
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 58 5e-09
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 57 9e-09
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 56 2e-08
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 51 8e-07
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14... 43 2e-04
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 42 5e-04
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 42 5e-04
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 36 0.021
gi|6912618 glutaminyl-peptide cyclotransferase precursor [Homo s... 32 0.31
gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E ... 32 0.31
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 433 bits (1113), Expect = e-122
Identities = 214/214 (100%), Positives = 214/214 (100%)
Query: 1 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA 60
MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA
Sbjct: 1 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA 60
Query: 61 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN 120
MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN
Sbjct: 61 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN 120
Query: 121 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 180
SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
Sbjct: 121 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 180
Query: 181 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 214
TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
Sbjct: 181 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 214
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 315 bits (806), Expect = 2e-86
Identities = 168/214 (78%), Positives = 168/214 (78%), Gaps = 46/214 (21%)
Query: 1 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAA 60
MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLG
Sbjct: 1 MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLG-------- 52
Query: 61 MILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQN 120
FCSSGTLSVVAGIKPTRTWIQN
Sbjct: 53 --------------------------------------FCSSGTLSVVAGIKPTRTWIQN 74
Query: 121 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 180
SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL
Sbjct: 75 SFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLIL 134
Query: 181 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 214
TLLELCVTISTIAMWCNANCCNSREEISSPPNSV
Sbjct: 135 TLLELCVTISTIAMWCNANCCNSREEISSPPNSV 168
>gi|73486651 membrane-spanning 4-domains, subfamily A, member 3
isoform c [Homo sapiens]
Length = 91
Score = 182 bits (461), Expect = 2e-46
Identities = 91/91 (100%), Positives = 91/91 (100%)
Query: 124 MNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLL 183
MNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLL
Sbjct: 1 MNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLL 60
Query: 184 ELCVTISTIAMWCNANCCNSREEISSPPNSV 214
ELCVTISTIAMWCNANCCNSREEISSPPNSV
Sbjct: 61 ELCVTISTIAMWCNANCCNSREEISSPPNSV 91
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 90.5 bits (223), Expect = 1e-18
Identities = 52/159 (32%), Positives = 86/159 (54%), Gaps = 4/159 (2%)
Query: 43 YQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSS 102
+ K + +VLG +QIL A M L++G+ + + + + Y GY IWG+V F S
Sbjct: 39 FLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPI---SVYIGYTIWGSVMFIIS 95
Query: 103 GTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDL 162
G+LS+ AGI+ T+ ++ S GMNI S+ +A G + ++A C+ S +
Sbjct: 96 GSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN- 154
Query: 163 CNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCC 201
C+ SI G+ ++L+L++LE C+ +S A C CC
Sbjct: 155 CHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 90.5 bits (223), Expect = 1e-18
Identities = 52/159 (32%), Positives = 86/159 (54%), Gaps = 4/159 (2%)
Query: 43 YQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSS 102
+ K + +VLG +QIL A M L++G+ + + + + Y GY IWG+V F S
Sbjct: 58 FLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPI---SVYIGYTIWGSVMFIIS 114
Query: 103 GTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDL 162
G+LS+ AGI+ T+ ++ S GMNI S+ +A G + ++A C+ S +
Sbjct: 115 GSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN- 173
Query: 163 CNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCC 201
C+ SI G+ ++L+L++LE C+ +S A C CC
Sbjct: 174 CHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 212
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 90.1 bits (222), Expect = 1e-18
Identities = 53/169 (31%), Positives = 90/169 (53%), Gaps = 4/169 (2%)
Query: 45 KAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGT 104
K K +VLG ++IL A M L++G+ + + + +++H F Y Y IWG+V F S +
Sbjct: 64 KRKPKVLGVVRILIALMSLSMGIIMMCVAFS-SYEEHPIFV--YVAYTIWGSVMFIISVS 120
Query: 105 LSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCN 164
LSV AGI+ T+ + S G NI S+ +A+ G ++++ C+ S + C
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSN-CY 179
Query: 165 YMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 213
SI G ++L+L++LE C+ +S A C CC+ E + P++
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSN 228
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 90.1 bits (222), Expect = 1e-18
Identities = 53/169 (31%), Positives = 90/169 (53%), Gaps = 4/169 (2%)
Query: 45 KAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGT 104
K K +VLG ++IL A M L++G+ + + + +++H F Y Y IWG+V F S +
Sbjct: 64 KRKPKVLGVVRILIALMSLSMGIIMMCVAFS-SYEEHPIFV--YVAYTIWGSVMFIISVS 120
Query: 105 LSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCN 164
LSV AGI+ T+ + S G NI S+ +A+ G ++++ C+ S + C
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSN-CY 179
Query: 165 YMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 213
SI G ++L+L++LE C+ +S A C CC+ E + P++
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSN 228
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 89.0 bits (219), Expect = 3e-18
Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 4/169 (2%)
Query: 45 KAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGT 104
K K +VLG ++IL A M L++G+ + + + +++H F Y Y IWG+V F S +
Sbjct: 64 KRKPKVLGVVRILIALMSLSMGIIMMCVAFS-SYEEHPIFV--YVAYTIWGSVMFIISVS 120
Query: 105 LSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCN 164
LSV AGI+ T+ + S G NI S+ +A+ G ++++ C+ S + C
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSN-CY 179
Query: 165 YMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 213
SI G ++L+L++LE C+ ++ A C CC+ E + P++
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSN 228
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 71.2 bits (173), Expect = 6e-13
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)
Query: 23 EAGPEELNTSVYQPIDGSPDYQ------KAKLQVLGAIQILNAAMILALGVFLGSLQYPY 76
E P+E+++ SP K + + LG QIL A + L G + S+
Sbjct: 27 EISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDIS 86
Query: 77 HFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGT 136
H + F +F GYP WGA+FF SG LS+++ + ++ S G N AS+ G
Sbjct: 87 HIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGI 145
Query: 137 AFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTIS 190
L +N+ ++ + HS + + +M S S +V ++L LT+L L +S
Sbjct: 146 TILIINLKKSLAYIH-IHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVS 198
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 69.3 bits (168), Expect = 2e-12
Identities = 59/206 (28%), Positives = 98/206 (47%), Gaps = 19/206 (9%)
Query: 11 LGSASAHGTPGSEAGPEELNTSVYQPIDGSPD-------YQKA---KLQVLGAIQILNAA 60
+ S++AH +P P E+ S Y+ + S QK K+++LG IQIL
Sbjct: 1 MDSSTAH-SPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKILGTIQILFGI 59
Query: 61 MILALGV-FLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQ 119
M + GV FL +L PY F F F +GYP WG+V F +SG + K T T I
Sbjct: 60 MTFSFGVIFLFTLLKPYPR----FPFIFLSGYPFWGSVLFINSGAFLIAVKRKTTETLII 115
Query: 120 NSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLI 179
S MN SA A+ G L+ ++ + C S ++ C + + G++ L+
Sbjct: 116 LSRIMNFLSALGAIAGIILLTFGFILDQNYI--CGYSHQNSQ-CKAVTVLFLGILITLMT 172
Query: 180 LTLLELCVTISTIAMWCNANCCNSRE 205
+++EL +++ + C++ C+ +
Sbjct: 173 FSIIELFISLPFSILGCHSEDCDCEQ 198
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 68.2 bits (165), Expect = 5e-12
Identities = 56/186 (30%), Positives = 85/186 (45%), Gaps = 23/186 (12%)
Query: 26 PEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFF 85
PE N Q D + A+++V+G IQIL M+L+LG+ L S + +F +
Sbjct: 27 PEPTN----QGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQ-VTST 81
Query: 86 TFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAV 145
+ YP G FF SG+LS+ + T+ + +S +I SA ALVG LS+ A
Sbjct: 82 LLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQAT 141
Query: 146 NIQSLRSC-----------------HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVT 188
+ C H S + D S++ G +SL+LI TLLE C+
Sbjct: 142 LNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLA-GTLSLMLICTLLEFCLA 200
Query: 189 ISTIAM 194
+ T +
Sbjct: 201 VLTAVL 206
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 68.2 bits (165), Expect = 5e-12
Identities = 56/186 (30%), Positives = 85/186 (45%), Gaps = 23/186 (12%)
Query: 26 PEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFF 85
PE N Q D + A+++V+G IQIL M+L+LG+ L S + +F +
Sbjct: 27 PEPTN----QGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQ-VTST 81
Query: 86 TFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAV 145
+ YP G FF SG+LS+ + T+ + +S +I SA ALVG LS+ A
Sbjct: 82 LLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQAT 141
Query: 146 NIQSLRSC-----------------HSSSESPDLCNYMGSISNGMVSLLLILTLLELCVT 188
+ C H S + D S++ G +SL+LI TLLE C+
Sbjct: 142 LNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLA-GTLSLMLICTLLEFCLA 200
Query: 189 ISTIAM 194
+ T +
Sbjct: 201 VLTAVL 206
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 66.6 bits (161), Expect = 1e-11
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 16/196 (8%)
Query: 19 TPG--SEAGPEELNTSVYQPIDGSPDYQ-KAKLQVLGAIQILNAAMILALGVFLGSLQYP 75
+PG + + P + N + P G+ K + + LG IQI+ M + G+ L + +
Sbjct: 56 SPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFS 115
Query: 76 YHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVG 135
+ F GYP WG + F SG+LSV A + +R ++ S GMNI S+ +A +G
Sbjct: 116 FREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIG 175
Query: 136 TAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSIS-NGMVSLLLILTLLELCVTISTIAM 194
L +++ +N + + +Y +S G+ + L+I +LLE V +T
Sbjct: 176 VILLLVDMCINGVAGQ------------DYWAVLSGKGISATLMIFSLLEFFVACATAHF 223
Query: 195 WCNANCCNSREEISSP 210
AN + + P
Sbjct: 224 ANQANTTTNMSVLVIP 239
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 65.9 bits (159), Expect = 3e-11
Identities = 50/185 (27%), Positives = 82/185 (44%), Gaps = 17/185 (9%)
Query: 32 SVYQPIDGSPDYQKAKL-QVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTG 90
S+ ++G P + K + LGAIQI+ + LG + ++ + +FY G
Sbjct: 52 SLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATV-----LVGEYLSISFYGG 106
Query: 91 YPIWGAVFFCSSGTLSVVAGIKP-TRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQS 149
+P WG ++F SG+LSV A +P + + S G+NI SA + VG ++++
Sbjct: 107 FPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI---- 162
Query: 150 LRSCHSSSESPDLCNYMGSISNGMV--SLLLILTLLELCVTISTIAMWCNANCCNSREEI 207
PD Y ++ GM +LL+ LLE + ++ C CC S
Sbjct: 163 ----PHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVS 218
Query: 208 SSPPN 212
PN
Sbjct: 219 VIYPN 223
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 60.5 bits (145), Expect = 1e-09
Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 23 EAGPEELNTSVYQPIDGSPDYQ------KAKLQVLGAIQILNAAMILALGVFLGSLQYPY 76
E P+E+++ SP K + + LG QIL A + L G + S+
Sbjct: 27 EISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDIS 86
Query: 77 HFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGT 136
H + F +F GYP WGA+FF SG LS+++ + ++ S G N AS+ G
Sbjct: 87 HIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGI 145
Query: 137 AFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSIS 170
L +N+ ++ + HS + + +M S S
Sbjct: 146 TILIINLKKSLAYIH-IHSCQKFFETKCFMASFS 178
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/178 (26%), Positives = 81/178 (45%), Gaps = 16/178 (8%)
Query: 33 VYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYP 92
+YQ D + + VLG +QIL +I +LG L YP HF T +GYP
Sbjct: 30 MYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAIST-TLMSGYP 88
Query: 93 IWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRS 152
GA+ F +G+LS+++G + T+ + +S N S+ A G L+ ++ + +
Sbjct: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
Query: 153 CHSSSESPDLCNY--------------MGSIS-NGMVSLLLILTLLELCVTISTIAMW 195
C S + Y + S+S G++ ++LI T+LEL + + W
Sbjct: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFW 206
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/178 (26%), Positives = 81/178 (45%), Gaps = 16/178 (8%)
Query: 33 VYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYP 92
+YQ D + + VLG +QIL +I +LG L YP HF T +GYP
Sbjct: 30 MYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAIST-TLMSGYP 88
Query: 93 IWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRS 152
GA+ F +G+LS+++G + T+ + +S N S+ A G L+ ++ + +
Sbjct: 89 FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148
Query: 153 CHSSSESPDLCNY--------------MGSIS-NGMVSLLLILTLLELCVTISTIAMW 195
C S + Y + S+S G++ ++LI T+LEL + + W
Sbjct: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFW 206
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 58.2 bits (139), Expect = 5e-09
Identities = 47/177 (26%), Positives = 70/177 (39%), Gaps = 26/177 (14%)
Query: 35 QPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIW 94
QPI Y + AIQIL + + YP F T+ +GYP+W
Sbjct: 133 QPIGYQRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYP--------FVTWLSGYPLW 184
Query: 95 GAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCH 154
G + + SG+LSV A P+ + +S NI SA A G + ++++
Sbjct: 185 GGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLYY------- 237
Query: 155 SSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPP 211
+ Y ++S G LL LLE +T C A CC E ++ P
Sbjct: 238 -------VTTYSKAVSGG----LLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 58.2 bits (139), Expect = 5e-09
Identities = 47/177 (26%), Positives = 70/177 (39%), Gaps = 26/177 (14%)
Query: 35 QPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIW 94
QPI Y + AIQIL + + YP F T+ +GYP+W
Sbjct: 133 QPIGYQRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYP--------FVTWLSGYPLW 184
Query: 95 GAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCH 154
G + + SG+LSV A P+ + +S NI SA A G + ++++
Sbjct: 185 GGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLYY------- 237
Query: 155 SSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPP 211
+ Y ++S G LL LLE +T C A CC E ++ P
Sbjct: 238 -------VTTYSKAVSGG----LLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 58.2 bits (139), Expect = 5e-09
Identities = 47/177 (26%), Positives = 70/177 (39%), Gaps = 26/177 (14%)
Query: 35 QPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIW 94
QPI Y + AIQIL + + YP F T+ +GYP+W
Sbjct: 133 QPIGYQRQYPVGTASLQTAIQILIGLTHIFSAINPVLYYYP--------FVTWLSGYPLW 184
Query: 95 GAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCH 154
G + + SG+LSV A P+ + +S NI SA A G + ++++
Sbjct: 185 GGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLYY------- 237
Query: 155 SSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPP 211
+ Y ++S G LL LLE +T C A CC E ++ P
Sbjct: 238 -------VTTYSKAVSGG----LLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 58.2 bits (139), Expect = 5e-09
Identities = 46/157 (29%), Positives = 72/157 (45%), Gaps = 13/157 (8%)
Query: 26 PEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFF 85
PE N Q D + A+++V+G IQIL M+L+LG+ L S + +F +
Sbjct: 27 PEPTN----QGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQ-VTST 81
Query: 86 TFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAV 145
+ YP G FF SG+LS+ + T+ + +S +I SA ALVG LS+ A
Sbjct: 82 LLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQAT 141
Query: 146 --------NIQSLRSCHSSSESPDLCNYMGSISNGMV 174
N S HS+ P + ++ G++
Sbjct: 142 LNPASLQWNSLSDADLHSAGILPSCAHCCAAVETGLL 178
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 57.4 bits (137), Expect = 9e-09
Identities = 48/181 (26%), Positives = 73/181 (40%), Gaps = 26/181 (14%)
Query: 35 QPIDGSP--DYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYP 92
QP D P + + +VLG +QIL + L G L ++ + H F G P
Sbjct: 56 QPPDLRPVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVR-----RGHVGIFFIEGGVP 110
Query: 93 IWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRS 152
WG F SG+LSV A T +++S G NI S A GTA L ++ V +
Sbjct: 111 FWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVTNR---- 166
Query: 153 CHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPN 212
+ G +++L I T+LE + + C A + + PN
Sbjct: 167 ---------------DVDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPN 211
Query: 213 S 213
+
Sbjct: 212 A 212
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 56.2 bits (134), Expect = 2e-08
Identities = 38/109 (34%), Positives = 56/109 (51%), Gaps = 5/109 (4%)
Query: 34 YQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPI 93
Y+P D+ K + +VLGA QIL A +I+ G +L Y Q+ TGYP
Sbjct: 28 YRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTIF-ALNYIGFSQR--LPLVVLTGYPF 84
Query: 94 WGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLN 142
WGA+ F +G L+V K ++ Q GMN+ S+ +A+ G F L+
Sbjct: 85 WGALIFILTGYLTVTD--KKSKLLGQGVTGMNVISSLVAITGITFTILS 131
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 50.8 bits (120), Expect = 8e-07
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 19/133 (14%)
Query: 81 HFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLS 140
H F G P WG F SG+LSV A T +++S G NI S A GTA L
Sbjct: 6 HVGIFFIEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILL 65
Query: 141 LNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANC 200
++ V + + G +++L I T+LE + + C A
Sbjct: 66 MDFGVTNR-------------------DVDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIH 106
Query: 201 CNSREEISSPPNS 213
+ + PN+
Sbjct: 107 AQASAPVIFLPNA 119
>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
isoform 2 [Homo sapiens]
Length = 662
Score = 42.7 bits (99), Expect = 2e-04
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 22/109 (20%)
Query: 34 YQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPI 93
Y+P D+ K + +VLGA QIL A +I+ G +L Y Q+ TGYP
Sbjct: 28 YRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTIF-ALNYIGFSQR--LPLVVLTGYPF 84
Query: 94 WGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLN 142
WGA+ Q GMN+ S+ +A+ G F L+
Sbjct: 85 WGALIG-------------------QGVTGMNVISSLVAITGITFTILS 114
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 41.6 bits (96), Expect = 5e-04
Identities = 43/215 (20%), Positives = 78/215 (36%), Gaps = 31/215 (14%)
Query: 18 GTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYH 77
G ++GP+ L + + + + + + LGA+QI+N +ALG G L P
Sbjct: 19 GPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALG---GLLMIPAG 75
Query: 78 FQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTA 137
+Y P+WG + + SG+L + ++ MN S A+ G
Sbjct: 76 IYAPICVTVWY---PLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMI 132
Query: 138 FLSLNIA----------------------VNIQSLRSCHSS---SESPDLCNYMGSISNG 172
++I +NI + + S S S C + S+ G
Sbjct: 133 LSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLG 192
Query: 173 MVSLLLILTLLELCVTISTIAMWCNANCCNSREEI 207
++S++LI + V + C + I
Sbjct: 193 ILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNI 227
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 41.6 bits (96), Expect = 5e-04
Identities = 43/215 (20%), Positives = 78/215 (36%), Gaps = 31/215 (14%)
Query: 18 GTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYH 77
G ++GP+ L + + + + + + LGA+QI+N +ALG G L P
Sbjct: 19 GPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALG---GLLMIPAG 75
Query: 78 FQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTA 137
+Y P+WG + + SG+L + ++ MN S A+ G
Sbjct: 76 IYAPICVTVWY---PLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMI 132
Query: 138 FLSLNIA----------------------VNIQSLRSCHSS---SESPDLCNYMGSISNG 172
++I +NI + + S S S C + S+ G
Sbjct: 133 LSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLG 192
Query: 173 MVSLLLILTLLELCVTISTIAMWCNANCCNSREEI 207
++S++LI + V + C + I
Sbjct: 193 ILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNI 227
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 36.2 bits (82), Expect = 0.021
Identities = 41/162 (25%), Positives = 69/162 (42%), Gaps = 18/162 (11%)
Query: 48 LQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSV 107
L+ LGA I A + L G +L S+ K+ + YP WGA F SG L++
Sbjct: 57 LKELGAFHITIALLHLVFGGYLASIV------KNLHLVVLKSWYPFWGAASFLISGILAI 110
Query: 108 VAGIKPTRTWIQNSFGM-NIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYM 166
++T+++ M N+ S L G +S ++ + S ESP Y
Sbjct: 111 TMKTF-SKTYLKMLCLMTNLISLFCVLSGLFVISKDLFL--------ESPFESPIWRMYP 161
Query: 167 GSISN--GMVSLLLILTLLELCVTISTIAMWCNANCCNSREE 206
S + + LL T+LEL + + T +C +++ +
Sbjct: 162 NSTVHIQRLELALLCFTVLELFLPVPTAVTAWRGDCPSAKND 203
>gi|6912618 glutaminyl-peptide cyclotransferase precursor [Homo
sapiens]
Length = 361
Score = 32.3 bits (72), Expect = 0.31
Identities = 19/61 (31%), Positives = 27/61 (44%)
Query: 16 AHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYP 75
A GT SE +L + + GSP A+ ++ IQ L A +L + FL Y
Sbjct: 57 AEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYG 116
Query: 76 Y 76
Y
Sbjct: 117 Y 117
>gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E
[Homo sapiens]
Length = 147
Score = 32.3 bits (72), Expect = 0.31
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 15/92 (16%)
Query: 118 IQNSFGMNIASATIALVGTAFLSLN-IAVNIQSLRSCHSSSESPDL-------------- 162
+ +S +I SA ALVG LS+N A+N SL+ + P
Sbjct: 50 VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMD 109
Query: 163 CNYMGSISNGMVSLLLILTLLELCVTISTIAM 194
C+ + G +SL+L+ T+LE C+ + T +
Sbjct: 110 CHRAKASLAGTLSLMLVSTVLEFCLAVLTAVL 141
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,881,218
Number of Sequences: 37866
Number of extensions: 293554
Number of successful extensions: 927
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 865
Number of HSP's gapped (non-prelim): 41
length of query: 214
length of database: 18,247,518
effective HSP length: 98
effective length of query: 116
effective length of database: 14,536,650
effective search space: 1686251400
effective search space used: 1686251400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.