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Search of human proteins with 71067343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71067343 cytochrome P450, family 11, subfamily B,
polypeptide 1 isoform 2 precursor [Homo sapiens]
(437 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 874 0.0
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 837 0.0
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 772 0.0
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 258 6e-69
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 172 7e-43
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 163 3e-40
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 154 2e-37
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 146 4e-35
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 141 1e-33
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 110 2e-24
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 60 3e-09
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 60 3e-09
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 60 3e-09
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 58 2e-08
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 56 7e-08
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 54 2e-07
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 54 2e-07
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 52 1e-06
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 49 7e-06
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 49 7e-06
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 47 3e-05
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 47 3e-05
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 47 3e-05
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 46 6e-05
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 46 8e-05
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 45 1e-04
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 41 0.002
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 41 0.002
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 41 0.002
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 41 0.002
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 874 bits (2258), Expect = 0.0
Identities = 437/437 (100%), Positives = 437/437 (100%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
Sbjct: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
Sbjct: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
Sbjct: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLTQEDIKMVYS 420
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLTQEDIKMVYS
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLTQEDIKMVYS 420
Query: 421 FILRPSMFPLLTFRAIN 437
FILRPSMFPLLTFRAIN
Sbjct: 421 FILRPSMFPLLTFRAIN 437
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 837 bits (2163), Expect = 0.0
Identities = 435/503 (86%), Positives = 436/503 (86%), Gaps = 66/503 (13%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
Sbjct: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
Sbjct: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
Sbjct: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQN-------------------------- 394
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQN
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
Query: 395 ------------------YHIPAG----------------------VLKHLQVETLTQED 414
YH+P G VLKHLQVETLTQED
Sbjct: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
Query: 415 IKMVYSFILRPSMFPLLTFRAIN 437
IKMVYSFILRPSMFPLLTFRAIN
Sbjct: 481 IKMVYSFILRPSMFPLLTFRAIN 503
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 772 bits (1994), Expect = 0.0
Identities = 403/503 (80%), Positives = 414/503 (82%), Gaps = 66/503 (13%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVC+A PWLSLQRA+ALGTRAAR PRTVLPFEAMP+ PGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YE LHLE+HQTFQELGPIFRY+LGG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYR
Sbjct: 61 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRW SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS
Sbjct: 241 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
+AIKANSMELTAGSVDTT FPLLMTLFELARNP+VQQ LRQESLAAAASISEHPQKATT
Sbjct: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQN-------------------------- 394
ELPLLRAALKETLRLYPVGLFLERV SSDLVLQN
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420
Query: 395 ------------------YHIPAG----------------------VLKHLQVETLTQED 414
+H+P G VLKH VETLTQED
Sbjct: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480
Query: 415 IKMVYSFILRPSMFPLLTFRAIN 437
IKMVYSFILRP PLLTFRAIN
Sbjct: 481 IKMVYSFILRPGTSPLLTFRAIN 503
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 258 bits (660), Expect = 6e-69
Identities = 147/391 (37%), Positives = 213/391 (54%), Gaps = 2/391 (0%)
Query: 25 GTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLG 84
G A R+ PF +P N WL L WRE G +HL Q FQ+ GPI+R LG
Sbjct: 35 GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94
Query: 85 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144
V V+ PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ L
Sbjct: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154
Query: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204
N EV++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +
Sbjct: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214
Query: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 264
FGER G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF
Sbjct: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274
Query: 265 QYGDNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 322
D Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT
Sbjct: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334
Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382
L L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L
Sbjct: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394
Query: 383 ERVASSDLVLQNYHIPAGVLKHLQVETLTQE 413
+R +DLVL++Y IPA L + + L +E
Sbjct: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 172 bits (435), Expect = 7e-43
Identities = 98/267 (36%), Positives = 150/267 (56%), Gaps = 2/267 (0%)
Query: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208
++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER
Sbjct: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268
G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D
Sbjct: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
Query: 269 NCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326
Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L
Sbjct: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Query: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386
L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R
Sbjct: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
Query: 387 SSDLVLQNYHIPAGVLKHLQVETLTQE 413
+DLVL++Y IPA L + + L +E
Sbjct: 241 VNDLVLRDYMIPAKTLVQVAIYALGRE 267
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 163 bits (413), Expect = 3e-40
Identities = 105/375 (28%), Positives = 185/375 (49%), Gaps = 6/375 (1%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
LLQI + G + H + + ++ G IFR LG V + P +E L + +S +P R+
Sbjct: 70 LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
++PW AYR +R G+ +L G +W+ R +++ P V + ++ V DF
Sbjct: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
+ + L + RG + D+ + ++ E+ L L+ +R GL+ + ++NF+ A++ M
Sbjct: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
+ ++M P L + + KVW++H AWD IF+ CI ++ + Q +
Sbjct: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
++ LS + A EL +V+TT L+ L+ L+RNP VQQ L +E +
Sbjct: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLT 411
+ +P L+A LKE++RL P F R VL Y +P G+++ ++
Sbjct: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATD 423
Query: 412 QEDIKMVYSFILRPS 426
E ++M++S L PS
Sbjct: 424 NEPVEMLHSGTLVPS 438
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 154 bits (388), Expect = 2e-37
Identities = 104/374 (27%), Positives = 178/374 (47%), Gaps = 6/374 (1%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
LLQI + G + H + + ++ G IFR LG V + P +E L + +S +P R+
Sbjct: 70 LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
++PW AYR +R G+ +L G +W+ R +++ P V + ++ V DF
Sbjct: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
+ + L + RG + D+ + ++ E+ L L+ +R GL+ + ++NF+ A++ M
Sbjct: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
+ ++M P L + + KVW++H AWD IF+ CI ++ + Q +
Sbjct: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
++ LS + A EL +V+TT L+ L+ L+RNP VQQ L +E +
Sbjct: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLT 411
+ +P L+A LKE++RL P F R VL Y +P G + L + L
Sbjct: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLG 423
Query: 412 QEDIKMVYSFILRP 425
+ S RP
Sbjct: 424 SSEDNFEDSSQFRP 437
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 146 bits (368), Expect = 4e-35
Identities = 114/363 (31%), Positives = 164/363 (45%), Gaps = 16/363 (4%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
L +++ + G LH Q GP++ G V V P VE+L + + P R
Sbjct: 49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERC 108
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
S PW +R+ R CG+ G EW+ R L P +L P A R+ ++ V D +
Sbjct: 109 SFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRR 168
Query: 172 LKKKVLQNARG----SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227
L++ Q RG +L DV + + +E L G RLG + + F+ A+
Sbjct: 169 LRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAV 225
Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---SRPQ 284
+F ST+ M MP L R P W WD +F + +++ E A +P+
Sbjct: 226 GSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPE 284
Query: 285 QYTSIVAEL---LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341
+ A L L EL +I N EL VDT L L+EL+R+P VQ AL
Sbjct: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
Query: 342 QESLAAAASISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399
E AA + S AT ++LPLL+A +KE LRLYPV RV D+ + +Y IP
Sbjct: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK 404
Query: 400 GVL 402
L
Sbjct: 405 NTL 407
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 141 bits (356), Expect = 1e-33
Identities = 109/407 (26%), Positives = 188/407 (46%), Gaps = 25/407 (6%)
Query: 4 RAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYED 63
RAKA + A+P A G R R++ E +PR R+ L + QGY
Sbjct: 26 RAKAAIPAALPSDKATGAPGAGPGVRRRQRSL---EEIPRLGQLRFFFQLFV---QGYA- 78
Query: 64 LHLEVHQTF----QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY 119
L++HQ + GP++ LG V + +E++ + + +P R +E W +
Sbjct: 79 --LQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEH 136
Query: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 179
R G F G W R LN +L P + + V DF L + ++
Sbjct: 137 RDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAES 196
Query: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239
A G+ D+ +++ +EA LF +R+G + S ++ F+ ++ +MF++++ F
Sbjct: 197 ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATF 256
Query: 240 MPRSLSRWTSPKV--WKEHFEAWDCIFQYG----DNCIQKIYQELAFSRPQ--QYTSIVA 291
+P+ WT P + WK + + W+ IF +G D ++ + +L + P Q + +
Sbjct: 257 LPK----WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLH 312
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
LL + +LSP + EL VDTT L L+ L+++P +Q+AL +E + +
Sbjct: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAG 372
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIP 398
K +PLL+A LKETLRLYPV R+ ++ + + P
Sbjct: 373 QVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFP 419
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 110 bits (276), Expect = 2e-24
Identities = 81/264 (30%), Positives = 126/264 (47%), Gaps = 9/264 (3%)
Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
L +L P V + V+ V D + + Q G +V F Y++E
Sbjct: 5 LRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATI 64
Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP---KVWKEHFEAW 260
L+ RLG + +S ++ ++ ALE+MF M+ ++ RW P K W+E +W
Sbjct: 65 LYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAG-AIPRWLRPFIPKPWREFCRSW 123
Query: 261 DCIFQYG----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316
D +F++ DN ++ I ++ R + ++ L L+ L+ I AN E+ V
Sbjct: 124 DGLFKFSQIHVDNKLRDIQYQMDRGR-RVSGGLLTYLFLSQALTLQEIYANVTEMLLAGV 182
Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376
DTT F L T++ LAR+P VQQ + +E + ++PL+RA LKETLRL+
Sbjct: 183 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLF 242
Query: 377 PVGLFLERVASSDLVLQNYHIPAG 400
PV RV DLV+ Y IP G
Sbjct: 243 PVLPGNGRVTQEDLVIGGYLIPKG 266
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 60.5 bits (145), Expect = 3e-09
Identities = 77/360 (21%), Positives = 153/360 (42%), Gaps = 39/360 (10%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGV 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G+
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 60.5 bits (145), Expect = 3e-09
Identities = 77/360 (21%), Positives = 153/360 (42%), Gaps = 39/360 (10%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGV 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G+
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 60.5 bits (145), Expect = 3e-09
Identities = 77/360 (21%), Positives = 153/360 (42%), Gaps = 39/360 (10%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGV 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G+
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/102 (34%), Positives = 52/102 (50%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L TL+ELA +P+VQQ L++E A + + A
Sbjct: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG 400
++ L + ETLRL+PV + LER D+ + IP G
Sbjct: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKG 391
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 55.8 bits (133), Expect = 7e-08
Identities = 33/104 (31%), Positives = 53/104 (50%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L ++ELA +P+VQQ L++E A + +
Sbjct: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVL 402
++ L + ETLRL+P+ + LERV D+ + IP GV+
Sbjct: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVV 393
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 54.3 bits (129), Expect = 2e-07
Identities = 33/104 (31%), Positives = 52/104 (50%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L ++ELA +P+VQQ +++E + +
Sbjct: 290 LSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDT 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVL 402
+L L + ETLRL+PV + LERV D+ + IP GV+
Sbjct: 350 VLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVV 393
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 54.3 bits (129), Expect = 2e-07
Identities = 37/106 (34%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHPQ 356
LS + I+A + G DTT L L+ LAR+P Q+ RQE L E
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGV 401
+LP L +KE+LRL+P F+ R + D+VL + IP G+
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGI 418
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 52.0 bits (123), Expect = 1e-06
Identities = 75/313 (23%), Positives = 124/313 (39%), Gaps = 32/313 (10%)
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
+L+PW+ G+ L G +WR +R L P N ++ ++ + A
Sbjct: 127 TLKPWLGD--------GLLLSVGDKWRHHRRLLTP-AFHFNILKPYIKIFSKSANIMHAK 177
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
++ ++ GS LDV I T+++ +F PS + ++
Sbjct: 178 WQRLAME---GSTCLDVFEHISLMTLDSLQKCIFSFDSNCQ-EKPSEYITAIMELSALVV 233
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
K Q F + + +P + H A + + D IQ+ + L + A
Sbjct: 234 KRNNQF-FRYKDFLYFLTPCGRRFH-RACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKA 291
Query: 292 E---------LLLNA-----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ 337
+ LLL+ ELS + I+A + G DTT L L+ LAR+P Q
Sbjct: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 338 QALRQE--SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395
+ RQE L E +LP L LKE+LRL+P R + D+VL +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
Query: 396 H-IPAGVLKHLQV 407
IP G + ++ +
Sbjct: 412 RVIPKGNVCNINI 424
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 49.3 bits (116), Expect = 7e-06
Identities = 34/99 (34%), Positives = 47/99 (47%), Gaps = 4/99 (4%)
Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATTELPL 364
+++L G +TT L + L +P +QQ L++E L AS S P K LPL
Sbjct: 256 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 315
Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGVL 402
L A + E LRL P V L L + + Y IP G +
Sbjct: 316 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTV 354
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 49.3 bits (116), Expect = 7e-06
Identities = 34/99 (34%), Positives = 47/99 (47%), Gaps = 4/99 (4%)
Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATTELPL 364
+++L G +TT L + L +P +QQ L++E L AS S P K LPL
Sbjct: 286 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 345
Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGVL 402
L A + E LRL P V L L + + Y IP G +
Sbjct: 346 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTV 384
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 47.4 bits (111), Expect = 3e-05
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGVL 402
+LP L +KE+LRL+P + R + D VL + IP G++
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIV 419
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 47.4 bits (111), Expect = 3e-05
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGVL 402
+LP L +KE+LRL+P + R + D VL + IP G++
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIV 419
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 47.0 bits (110), Expect = 3e-05
Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 3/108 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
+LS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGVL 402
+LP L +KE+LRL+P + R + D+VL + IP G++
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGII 419
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
+LS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGVL 402
LP L +KE+LRL+P + R + D+VL + IP G++
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGII 419
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 45.8 bits (107), Expect = 8e-05
Identities = 77/352 (21%), Positives = 138/352 (39%), Gaps = 51/352 (14%)
Query: 77 PIFRYDLGGAGMVCVMLPEDVEKL----QQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 132
P+ + +G MV + E+VE + +Q+D ++ LEPW+ G+
Sbjct: 88 PLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKF-LEPWLGL--------GLLTS 138
Query: 133 NGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192
G +WR R L P ++ FL +++ A + L+K + Q A
Sbjct: 139 TGNKWRSRRKMLTP-TFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCF-------- 189
Query: 193 FHYTIEASNL---ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249
F+ T+ A ++ G+ +G + S E++F+ +++ ++ L
Sbjct: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR-IKMPWLWLDLWYLMF 248
Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP-----------QQYTSIVAELLLNA- 297
+ W EH ++ + + ++ I + E+ + + +LLL+
Sbjct: 249 KEGW-EHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVT 307
Query: 298 -----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASIS 352
LS + I+ DTT + +L+ L NP VQ+ + E L S
Sbjct: 308 DDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE-LDDVFGKS 366
Query: 353 EHPQKATTE----LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG 400
+ P AT E L L +KETLRL+P R S D + Y + G
Sbjct: 367 DRP--ATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKG 416
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 45.4 bits (106), Expect = 1e-04
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT + LF LA+ P Q+ R+E + + E
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGVL 402
T+LP +KE+LR YP + R + D+ L + IP G++
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGII 426
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 41.2 bits (95), Expect = 0.002
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369
+L DTT LL L ++ NP+VQ+ + +E + ++P A +
Sbjct: 348 DLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATI 407
Query: 370 KETLRL-YPVGLFLERVASSDLVLQNYHIPAGVL 402
E RL V L + + S + VLQ Y IP G L
Sbjct: 408 MEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTL 441
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 40.8 bits (94), Expect = 0.002
Identities = 69/311 (22%), Positives = 115/311 (36%), Gaps = 34/311 (10%)
Query: 113 LEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNP----EVLSPNA---VQRFLPMVDAVA 165
L PW+ Y G+ LLNG W +R L P ++L P M+D
Sbjct: 123 LAPWIGY--------GLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWE 174
Query: 166 RDFSQALKKKVLQNARGSLTLD-VQPSIFHY--TIEAS-NLALFGERLGLVGHSPSSASL 221
Q +V Q+ +TLD + F + +I+ N + + + + + S
Sbjct: 175 ELLGQDSPLEVFQHV-SLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVR 233
Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFS 281
N H + ++ T S RWT H + D + Q +QK +
Sbjct: 234 NAFHQNDTIYSLT--------SAGRWTHRACQLAH-QHTDQVIQLRKAQLQKEGELEKIK 284
Query: 282 RPQQYTSIVAELLLNAE----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ 337
R + + LL E LS ++A DTT + L+ LA +P Q
Sbjct: 285 RKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ 344
Query: 338 QALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL-QNYH 396
+ R+E + + ++P +KE LRLYP + R S+ +
Sbjct: 345 ERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRS 404
Query: 397 IPAGVLKHLQV 407
+P G++ L +
Sbjct: 405 LPKGIMVLLSI 415
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 40.8 bits (94), Expect = 0.002
Identities = 69/332 (20%), Positives = 128/332 (38%), Gaps = 44/332 (13%)
Query: 99 KLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFL 158
K Q S H++ LE WV G+ L+G +W+ +R + P + + ++ F+
Sbjct: 104 KRQDPKSAVSHKI-LESWVGR--------GLVTLDGSKWKKHRQIVKPG-FNISILKIFI 153
Query: 159 PMVDAVARDFSQALKKKVLQNARGSL-------TLD-VQPSIFHY--------TIEASNL 202
M+ R ++ + QN+R L TLD + F + T+++
Sbjct: 154 TMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLK 213
Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPR---SLSRWTSPKVWKEHFEA 259
A+F + + NFLH +++FK + Q + L ++T +
Sbjct: 214 AVFN-----LSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESL 268
Query: 260 WDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTT 319
D + Q + + ++ S + T +E L AE+ + DTT
Sbjct: 269 KDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH---------DTT 319
Query: 320 VFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379
+ L+ LA+ P QQ R E S + +++P +KE LRLY
Sbjct: 320 SSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPV 379
Query: 380 LFLERVASSDLVL-QNYHIPAGVLKHLQVETL 410
+ + R+ + +PAG+ + + L
Sbjct: 380 VNISRLLDKPITFPDGRSLPAGITVFINIWAL 411
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 40.8 bits (94), Expect = 0.002
Identities = 79/357 (22%), Positives = 137/357 (38%), Gaps = 43/357 (12%)
Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEK--LQQVDSLHPHRMSLEPWVAYRQH 122
H+ + + Q G IF DLGG V V+ DV K L + R L ++ +
Sbjct: 63 HVYMRKQSQVYGEIFSLDLGGISTV-VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121
Query: 123 RGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK--KKVLQNA 180
G LLN R+ R ++ L+ N+ + F + + K ++
Sbjct: 122 GG------LLNS---RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL--- 237
+G D + I + +NL +FGER + +F H +E +F V+L
Sbjct: 173 KGR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAAS 223
Query: 238 --MFMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAE 292
+F+ + W + +H F ++ + I+K PQ + +
Sbjct: 224 ASVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD 282
Query: 293 LLLNAELSPDAI--KANSM----ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 346
+ + P + K N + EL +TT L + +A PN+Q +++E
Sbjct: 283 EMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDL 342
Query: 347 AAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAG 400
+ ++P A L E LR + P+G+F S D V++ Y IP G
Sbjct: 343 IMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKG 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,652,996
Number of Sequences: 37866
Number of extensions: 659195
Number of successful extensions: 1617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 1544
Number of HSP's gapped (non-prelim): 69
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.