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Search of human proteins with 7019547
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7019547 TANK-binding kinase 1 [Homo sapiens]
(729 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7019547 TANK-binding kinase 1 [Homo sapiens] 1467 0.0
gi|7661946 IKK-related kinase epsilon [Homo sapiens] 660 0.0
gi|41352712 inhibitor of nuclear factor kappa B kinase beta subu... 136 8e-32
gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo s... 128 2e-29
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 113 7e-25
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 110 6e-24
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 110 6e-24
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 109 1e-23
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 108 2e-23
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 104 3e-22
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 104 3e-22
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 102 1e-21
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 100 4e-21
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 100 4e-21
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 98 2e-20
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 98 2e-20
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 98 2e-20
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 98 2e-20
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 98 2e-20
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 98 2e-20
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 98 2e-20
gi|115529463 protein kinase D1 [Homo sapiens] 97 7e-20
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 96 9e-20
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 96 9e-20
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 96 9e-20
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 96 1e-19
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 96 1e-19
gi|5031689 protein kinase D3 [Homo sapiens] 96 2e-19
>gi|7019547 TANK-binding kinase 1 [Homo sapiens]
Length = 729
Score = 1467 bits (3798), Expect = 0.0
Identities = 729/729 (100%), Positives = 729/729 (100%)
Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
Sbjct: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60
Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
Sbjct: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120
Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
Sbjct: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180
Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
Sbjct: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240
Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300
KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
Sbjct: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300
Query: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
Sbjct: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360
Query: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420
LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
Sbjct: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420
Query: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480
VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
Sbjct: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480
Query: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540
VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE
Sbjct: 481 VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE 540
Query: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600
GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
Sbjct: 541 GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH 600
Query: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ
Sbjct: 601 FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ 660
Query: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720
KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
Sbjct: 661 KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD 720
Query: 721 GGLRNVDCL 729
GGLRNVDCL
Sbjct: 721 GGLRNVDCL 729
>gi|7661946 IKK-related kinase epsilon [Homo sapiens]
Length = 716
Score = 660 bits (1702), Expect = 0.0
Identities = 351/717 (48%), Positives = 468/717 (65%), Gaps = 15/717 (2%)
Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK 60
MQST+N+LW D+LGQGATA+V++ R+KK+G+L A+KVFN S+LRP +VQ+REFEVL+
Sbjct: 1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR 60
Query: 61 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 120
KLNH+NIVKLFA+EE +R KVL+ME+C GSL +VLE P NA+GLPE EFL+VLR VV
Sbjct: 61 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV 120
Query: 121 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 180
GMNHLRENGIVHRDIKPGNIMR++GE+GQS+YKLTDFGAAREL+DDE+FVS+YGTEEYL
Sbjct: 121 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL 180
Query: 181 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240
HPDMYERAVLRK QK +G TVDLWSIGVT YHAATGSLPF PF GPRRNKE+MY+I T
Sbjct: 181 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE 240
Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA 300
KP+GAI+G Q+ ENGP++WS +P++C LS GLQ L P+LANILE +Q KCWGFDQFFA
Sbjct: 241 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA 300
Query: 301 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV 360
ETSDIL R+V+HVFSL Q H IYIH++NT IF E V+KQT + +QE ++EG V
Sbjct: 301 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV 360
Query: 361 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG 420
LEP AQH TT +P+ + S + + +PK P+ DL D + AK + G
Sbjct: 361 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 420
Query: 421 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK 480
A R+A LL QELM +G+ W++E+++ T+ ++ L +
Sbjct: 421 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGT------ 474
Query: 481 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH 538
E+ + E EL +++ ++L L+ ++ + LS SL
Sbjct: 475 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK 529
Query: 539 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM 598
+DR+++++Q L+ M IY QFKK + L YNEEQIHK DK + A + +
Sbjct: 530 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL 589
Query: 599 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL 658
F +ECV+KY+A L + +R + R L + E QE ++L E L
Sbjct: 590 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL 649
Query: 659 PQKMF-TASSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILER 713
++ + G + + PI P S T ++ L M++L E M+ + +L +NN I+ER
Sbjct: 650 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIER 706
>gi|41352712 inhibitor of nuclear factor kappa B kinase beta subunit
[Homo sapiens]
Length = 756
Score = 136 bits (342), Expect = 8e-32
Identities = 100/356 (28%), Positives = 160/356 (44%), Gaps = 23/356 (6%)
Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68
W + + LG G NV R +++TG+ AIK R + E +++++L H N+V
Sbjct: 15 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 74
Query: 69 KLFAIEEETTTRHK----VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124
+ E +L ME+C G L L + N GL E L +L D+ +
Sbjct: 75 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 134
Query: 125 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184
+L EN I+HRD+KP NI+ GE + ++K+ D G A+EL+ S GT +YL P++
Sbjct: 135 YLHENRIIHRDLKPENIVLQQGEQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193
Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244
E Q+KY TVD WS G + TG PF P P V + + S
Sbjct: 194 LE--------QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQP-----VQWHSKVRQKSE 240
Query: 245 AISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANIL-----EADQEKCWGFDQFF 299
V + NG + +S +P +L+ L L L +L + + +G + F
Sbjct: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF 300
Query: 300 AETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYE 355
DIL+ ++H+ ++ T H + + + + T I +QEL+ E
Sbjct: 301 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQE 356
>gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo
sapiens]
Length = 745
Score = 128 bits (321), Expect = 2e-29
Identities = 106/365 (29%), Positives = 170/365 (46%), Gaps = 40/365 (10%)
Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68
W + + LG G NV +H++ AIK + + E +++KKLNH N+V
Sbjct: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 74
Query: 69 KLFAIEEETTTR-HKV--LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125
K + EE H V L ME+C G L +L +P N GL ES+ L +L D+ G+ +
Sbjct: 75 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 134
Query: 126 LRENGIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184
L EN I+HRD+KP NI ++ +G G+ ++K+ D G A++++ S GT +YL P++
Sbjct: 135 LHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPEL 192
Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----RPFEGPRRNKEVMYKIITG 240
+E K Y ATVD WS G + G PF +PF + K+ K I
Sbjct: 193 FE--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIF- 243
Query: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG------ 294
+ +G + +S +P SL + + L +L D ++ G
Sbjct: 244 --------ACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTL 295
Query: 295 -FDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHEL---VYKQTKIISSNQ 350
+ F IL+ ++H+ + MT+ KI H L + ++T I + +Q
Sbjct: 296 KQPRCFVLMDHILNLKIVHILN---MTSAKIISFLLPPDESLHSLQSRIERETGINTGSQ 352
Query: 351 ELIYE 355
EL+ E
Sbjct: 353 ELLSE 357
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 113 bits (282), Expect = 7e-25
Identities = 73/217 (33%), Positives = 110/217 (50%), Gaps = 21/217 (9%)
Query: 13 DILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71
D++G GA A VF+GRH++ DL A+K N + + + +E ++LK+L H+NIV L+
Sbjct: 20 DLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALY 79
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
+E + + L+ME+C G L L L E + L+ + G M L GI
Sbjct: 80 DFQEMANSVY--LVMEYCNGGDLADYLHAMRT---LSEDTIRLFLQQIAGAMRLLHSKGI 134
Query: 132 VHRDIKPGNIMRVIGEDGQSV------YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185
+HRD+KP NI+ + G+ K+ DFG AR L+ + +L G+ Y+ P+
Sbjct: 135 IHRDLKPQNIL-LSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE-- 191
Query: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222
V+ H Y DLWSIG Y TG PF+
Sbjct: 192 ---VIMSQH---YDGKADLWSIGTIVYQCLTGKAPFQ 222
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 110 bits (274), Expect = 6e-24
Identities = 73/216 (33%), Positives = 106/216 (49%), Gaps = 19/216 (8%)
Query: 13 DILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71
D++G GA A VFRGRH++ D AIK N + + + +E ++LK+L H+NIV L+
Sbjct: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALY 72
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
++E + L+ME+C G L L+ L E + L + M L GI
Sbjct: 73 DVQELPNS--VFLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAMRILHSKGI 127
Query: 132 VHRDIKPGNIMRVIGEDGQSV-----YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186
+HRD+KP NI+ +S K+ DFG AR L + +L G+ Y+ P+
Sbjct: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPE--- 184
Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222
V+ H Y A DLWSIG Y G PF+
Sbjct: 185 --VIMSQH---YDAKADLWSIGTVIYQCLVGKPPFQ 215
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 110 bits (274), Expect = 6e-24
Identities = 73/216 (33%), Positives = 106/216 (49%), Gaps = 19/216 (8%)
Query: 13 DILGQGATANVFRGRHKKTGDL-FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLF 71
D++G GA A VFRGRH++ D AIK N + + + +E ++LK+L H+NIV L+
Sbjct: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALY 72
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
++E + L+ME+C G L L+ L E + L + M L GI
Sbjct: 73 DVQELPNS--VFLVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAMRILHSKGI 127
Query: 132 VHRDIKPGNIMRVIGEDGQSV-----YKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186
+HRD+KP NI+ +S K+ DFG AR L + +L G+ Y+ P+
Sbjct: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPE--- 184
Query: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222
V+ H Y A DLWSIG Y G PF+
Sbjct: 185 --VIMSQH---YDAKADLWSIGTVIYQCLVGKPPFQ 215
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 109 bits (272), Expect = 1e-23
Identities = 73/213 (34%), Positives = 111/213 (52%), Gaps = 16/213 (7%)
Query: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68
++ ++LG GA + VF + + TG LFA+K R ++ E VLKK+ H+NIV
Sbjct: 23 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE-NEIAVLKKIKHENIV 81
Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128
L I E TT H L+M+ G L+ + E Y E + +V++ V+ + +L E
Sbjct: 82 TLEDIYESTT--HYYLVMQLVSGGELFDRILE-RGVY--TEKDASLVIQQVLSAVKYLHE 136
Query: 129 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188
NGIVHRD+KP N++ + E+ + +TDFG ++ +E + + GT Y+ P++
Sbjct: 137 NGIVHRDLKPENLLYLTPEENSKI-MITDFGLSK-MEQNGIMSTACGTPGYVAPEVLA-- 192
Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221
QK Y VD WSIGV Y G PF
Sbjct: 193 ------QKPYSKAVDCWSIGVITYILLCGYPPF 219
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 108 bits (269), Expect = 2e-23
Identities = 67/225 (29%), Positives = 113/225 (50%), Gaps = 18/225 (8%)
Query: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73
++G G A V RH++T +A+K+ + D+ E +++ L+H NIVKL +
Sbjct: 361 VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEV 420
Query: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133
E T LI+E+ G L+ + E + PE + +++ D+ + H+ + IVH
Sbjct: 421 YE--TDMEIYLILEYVQGGDLFDAIIE---SVKFPEPDAALMIMDLCKALVHMHDKSIVH 475
Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKD 193
RD+KP N++ ED + KL DFG A+ + ++ GT Y+ P++
Sbjct: 476 RDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPEILS------- 526
Query: 194 HQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238
+K YG VD+W+ GV Y G F PF P R+++ ++ II
Sbjct: 527 -EKGYGLEVDMWAAGVILYILLCG---FPPFRSPERDQDELFNII 567
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 104 bits (259), Expect = 3e-22
Identities = 76/235 (32%), Positives = 116/235 (49%), Gaps = 27/235 (11%)
Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIV 68
L +G+G A V RH TG A+K+ + L P +Q RE ++K LNH NIV
Sbjct: 62 LQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIV 120
Query: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLR 127
KLF + E T + L+ME+ G ++ L A+G + E E R +V + +
Sbjct: 121 KLFEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 128 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187
+ IVHRD+K N++ DG K+ DFG + E + + G+ Y P++++
Sbjct: 175 QKYIVHRDLKAENLLL----DGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230
Query: 188 AVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 231 --------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 273
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 104 bits (259), Expect = 3e-22
Identities = 73/230 (31%), Positives = 113/230 (49%), Gaps = 25/230 (10%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72
+G+G A V RH TG AIK+ + L P +Q RE ++K LNH NIVKLF
Sbjct: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPSSLQKLFREVRIMKGLNHPNIVKLFE 123
Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132
+ E T + L+ME+ G ++ L + E E R +V +++ + IV
Sbjct: 124 VIETEKTLY--LVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVSAVHYCHQKNIV 178
Query: 133 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192
HRD+K N++ D ++ K+ DFG + E + + G+ Y P++++
Sbjct: 179 HRDLKAENLLL----DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG----- 229
Query: 193 DHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF KE+ +++ GK
Sbjct: 230 ---KKYDGPEVDIWSLGVILYTLVSGSLPF----DGHNLKELRERVLRGK 272
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 102 bits (255), Expect = 1e-21
Identities = 75/213 (35%), Positives = 105/213 (49%), Gaps = 23/213 (10%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM---REFEVLKKLNHKNIVKLF 71
LG+G+ A V G H TG+ AIKV + + V RE ++ + + H NI +L
Sbjct: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
I E T L+ME CP G+L + E L ESE +R ++ + HL G+
Sbjct: 128 DILE--TENSYYLVMELCPGGNLMHKIYEKKR---LEESEARRYIRQLISAVEHLHRAGV 182
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFG---AARELEDDEQFVSLYGTEEYLHPDMYERA 188
VHRD+K N++ + ED KL DFG A L + F + G+ Y P++ R
Sbjct: 183 VHRDLKIENLL--LDEDNN--IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLAR- 237
Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221
KKYG +D+WSIGV Y TG+LPF
Sbjct: 238 -------KKYGPKIDVWSIGVNMYAMLTGTLPF 263
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 100 bits (250), Expect = 4e-21
Identities = 76/231 (32%), Positives = 114/231 (49%), Gaps = 27/231 (11%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72
+G+G A V RH TG AIK+ + L P +Q RE ++K LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRENGI 131
+ E T + LIME+ G ++ L A+G + E E R +V + + + I
Sbjct: 121 VIETEKTLY--LIMEYASGGEVFDYLV----AHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 175 VHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG---- 226
Query: 192 KDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 227 ----KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 269
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 100 bits (250), Expect = 4e-21
Identities = 76/231 (32%), Positives = 114/231 (49%), Gaps = 27/231 (11%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72
+G+G A V RH TG AIK+ + L P +Q RE ++K LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRENGI 131
+ E T + LIME+ G ++ L A+G + E E R +V + + + I
Sbjct: 121 VIETEKTLY--LIMEYASGGEVFDYLV----AHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 175 VHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG---- 226
Query: 192 KDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 227 ----KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 269
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 100 bits (250), Expect = 4e-21
Identities = 76/231 (32%), Positives = 114/231 (49%), Gaps = 27/231 (11%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72
+G+G A V RH TG AIK+ + L P +Q RE ++K LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRENGI 131
+ E T + LIME+ G ++ L A+G + E E R +V + + + I
Sbjct: 121 VIETEKTLY--LIMEYASGGEVFDYLV----AHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 175 VHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG---- 226
Query: 192 KDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 227 ----KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 269
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 100 bits (250), Expect = 4e-21
Identities = 76/231 (32%), Positives = 114/231 (49%), Gaps = 27/231 (11%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKNIVKLFA 72
+G+G A V RH TG AIK+ + L P +Q RE ++K LNH NIVKLF
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLRENGI 131
+ E T + LIME+ G ++ L A+G + E E R +V + + + I
Sbjct: 121 VIETEKTLY--LIMEYASGGEVFDYLV----AHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 175 VHRDLKAENLLL----DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG---- 226
Query: 192 KDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 227 ----KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 269
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNHKNIVKL 70
+G+G A V RH TG A+K+ + N S L+ + RE ++K LNH NIVKL
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNHPNIVKL 115
Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129
F + E T + L+ME+ G ++ L A+G + E E R +V + + +
Sbjct: 116 FEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189
IVHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 170 FIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG-- 223
Query: 190 LRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 224 ------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 266
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNHKNIVKL 70
+G+G A V RH TG A+K+ + N S L+ + RE ++K LNH NIVKL
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNHPNIVKL 115
Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129
F + E T + L+ME+ G ++ L A+G + E E R +V + + +
Sbjct: 116 FEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189
IVHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 170 FIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG-- 223
Query: 190 LRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 224 ------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 266
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNHKNIVKL 70
+G+G A V RH TG A+K+ + N S L+ + RE ++K LNH NIVKL
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNHPNIVKL 115
Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129
F + E T + L+ME+ G ++ L A+G + E E R +V + + +
Sbjct: 116 FEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189
IVHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 170 FIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG-- 223
Query: 190 LRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 224 ------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 266
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNHKNIVKL 70
+G+G A V RH TG A+K+ + N S L+ + RE ++K LNH NIVKL
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNHPNIVKL 115
Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129
F + E T + L+ME+ G ++ L A+G + E E R +V + + +
Sbjct: 116 FEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189
IVHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 170 FIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG-- 223
Query: 190 LRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 224 ------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 266
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 98.2 bits (243), Expect = 2e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFN----NISFLRPVDVQMREFEVLKKLNHKNIVKL 70
+G+G A V RH TG A+K+ + N S L+ + RE ++K LNH NIVKL
Sbjct: 26 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL---FREVRIMKVLNHPNIVKL 82
Query: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEFLIVLRDVVGGMNHLREN 129
F + E T + L+ME+ G ++ L A+G + E E R +V + + +
Sbjct: 83 FEVIETEKTLY--LVMEYASGGEVFDYLV----AHGRMKEKEARAKFRQIVSAVQYCHQK 136
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189
IVHRD+K N++ D K+ DFG + E + + G+ Y P++++
Sbjct: 137 FIVHRDLKAENLLL----DADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG-- 190
Query: 190 LRKDHQKKY-GATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
KKY G VD+WS+GV Y +GSLPF + KE+ +++ GK
Sbjct: 191 ------KKYDGPEVDVWSLGVILYTLVSGSLPF----DGQNLKELRERVLRGK 233
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 98.2 bits (243), Expect = 2e-20
Identities = 73/235 (31%), Positives = 114/235 (48%), Gaps = 36/235 (15%)
Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIK-----VFNNISFLRPVDVQMRE 55
++S LW +ILG+GA V+ G + G L A+K N ++ + E
Sbjct: 1053 LKSEEPILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEE 1111
Query: 56 FEVLKKLNHKNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEF 112
++LK L H NIV ++E T + + MEF P GS+ +++ N +G LPE F
Sbjct: 1112 VDLLKALKHVNIVAYLGTCLQENTVS----IFMEFVPGGSISSII----NRFGPLPEMVF 1163
Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-------E 165
+ ++ G+ +L EN +VHRDIK N+M + + KL DFG AR L
Sbjct: 1164 CKYTKQILQGVAYLHENCVVHRDIKGNNVMLM----PTGIIKLIDFGCARRLAWAGLNGT 1219
Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220
+ S++GT ++ P++ ++ YG D+WSIG T + ATG P
Sbjct: 1220 HSDMLKSMHGTPYWMAPEVI--------NESGYGRKSDIWSIGCTVFEMATGKPP 1266
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 98.2 bits (243), Expect = 2e-20
Identities = 73/235 (31%), Positives = 114/235 (48%), Gaps = 36/235 (15%)
Query: 1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIK-----VFNNISFLRPVDVQMRE 55
++S LW +ILG+GA V+ G + G L A+K N ++ + E
Sbjct: 235 LKSEEPILWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKLAAEKEYRKLQEE 293
Query: 56 FEVLKKLNHKNIVKLFA--IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEF 112
++LK L H NIV ++E T + + MEF P GS+ +++ N +G LPE F
Sbjct: 294 VDLLKALKHVNIVAYLGTCLQENTVS----IFMEFVPGGSISSII----NRFGPLPEMVF 345
Query: 113 LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-------E 165
+ ++ G+ +L EN +VHRDIK N+M + + KL DFG AR L
Sbjct: 346 CKYTKQILQGVAYLHENCVVHRDIKGNNVMLM----PTGIIKLIDFGCARRLAWAGLNGT 401
Query: 166 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLP 220
+ S++GT ++ P++ ++ YG D+WSIG T + ATG P
Sbjct: 402 HSDMLKSMHGTPYWMAPEVI--------NESGYGRKSDIWSIGCTVFEMATGKPP 448
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 96.7 bits (239), Expect = 7e-20
Identities = 69/214 (32%), Positives = 107/214 (50%), Gaps = 14/214 (6%)
Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKNIVKLF 71
++LG G V+ G+H+KTG AIK+ + + F + Q+R E +L+ L+H +V L
Sbjct: 587 EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLE 646
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
+ E T ++ME L +L S LPE ++ ++ + HL I
Sbjct: 647 CMFE--TPERVFVVMEKLHGDMLEMILS--SEKGRLPEHITKFLITQILVALRHLHFKNI 702
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VH D+KP N++ + V KL DFG AR + + S+ GT YL P+ VLR
Sbjct: 703 VHCDLKPENVLLASADPFPQV-KLCDFGFARIIGEKSFRRSVVGTPAYLAPE-----VLR 756
Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225
K Y ++D+WS+GV Y + +G+ PF E
Sbjct: 757 ---NKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 787
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 96.3 bits (238), Expect = 9e-20
Identities = 61/211 (28%), Positives = 107/211 (50%), Gaps = 20/211 (9%)
Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFL-RPVDVQMREFEVLKKLNHKNIVKLF 71
+++G+G+ V++GR K + + A+K + + + RE E+++ L H NIV +
Sbjct: 8 EMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHM- 66
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
++ T + V++ ++ G L+ +LE+ LPE + + +V + +L + I
Sbjct: 67 -LDSFETDKEVVVVTDYAE-GELFQILEDDGK---LPEDQVQAIAAQLVSALYYLHSHRI 121
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-FVSLYGTEEYLHPDMYERAVL 190
+HRD+KP NI+ G KL DFG AR + + S+ GT Y+ P++ E
Sbjct: 122 LHRDMKPQNILLAKG----GGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVE---- 173
Query: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221
++ Y T DLWS+G Y A G+ PF
Sbjct: 174 ----ERPYDHTADLWSVGCILYELAVGTPPF 200
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 96.3 bits (238), Expect = 9e-20
Identities = 79/237 (33%), Positives = 123/237 (51%), Gaps = 28/237 (11%)
Query: 11 LSDILGQGATANVFRGRHKK---TGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKN 66
L +LGQG+ VF R K G L+A+KV + V+ + E ++L ++NH
Sbjct: 69 LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF 128
Query: 67 IVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125
IVKL +A + E LI++F G L+T L S E + L ++ ++H
Sbjct: 129 IVKLHYAFQTEGKL---YLILDFLRGGDLFTRL---SKEVMFTEEDVKFYLAELALALDH 182
Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184
L GI++RD+KP NI+ + E+G K+TDFG ++E ++ D++ S GT EY+ P++
Sbjct: 183 LHSLGIIYRDLKPENIL--LDEEGH--IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
V R+ H + + D WS GV + TGSLPF+ + KE M I+ K
Sbjct: 239 ----VNRRGHTQ----SADWWSFGVLMFEMLTGSLPFQ----GKDRKETMALILKAK 283
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/235 (26%), Positives = 109/235 (46%), Gaps = 25/235 (10%)
Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69
+ + +G G+ + R HK T +A+K+ + S P + E E+L + H NI+
Sbjct: 425 IKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK-SKRDPSE----EIEILLRYGQHPNIIT 479
Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129
L + ++ + L+ME G L L+ E E VL + M++L
Sbjct: 480 LKDVYDDG--KFVYLVMELMRGGEL---LDRILRQRYFSEREASDVLCTITKTMDYLHSQ 534
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERA 188
G+VHRD+KP NI+ ++ DFG A++L + ++ T ++ P++ +R
Sbjct: 535 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR- 593
Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKIITGK 241
+ Y A D+WS+G+ Y G PF P + P +E++ +I +GK
Sbjct: 594 -------QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTP---EEILARIGSGK 638
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 96.3 bits (238), Expect = 9e-20
Identities = 79/237 (33%), Positives = 123/237 (51%), Gaps = 28/237 (11%)
Query: 11 LSDILGQGATANVFRGRHKK---TGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKN 66
L +LGQG+ VF R K G L+A+KV + V+ + E ++L ++NH
Sbjct: 61 LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF 120
Query: 67 IVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125
IVKL +A + E LI++F G L+T L S E + L ++ ++H
Sbjct: 121 IVKLHYAFQTEGKL---YLILDFLRGGDLFTRL---SKEVMFTEEDVKFYLAELALALDH 174
Query: 126 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVSLYGTEEYLHPDM 184
L GI++RD+KP NI+ + E+G K+TDFG ++E ++ D++ S GT EY+ P++
Sbjct: 175 LHSLGIIYRDLKPENIL--LDEEGH--IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 230
Query: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGK 241
V R+ H + + D WS GV + TGSLPF+ + KE M I+ K
Sbjct: 231 ----VNRRGHTQ----SADWWSFGVLMFEMLTGSLPFQ----GKDRKETMALILKAK 275
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/235 (26%), Positives = 109/235 (46%), Gaps = 25/235 (10%)
Query: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLN-HKNIVK 69
+ + +G G+ + R HK T +A+K+ + S P + E E+L + H NI+
Sbjct: 417 IKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK-SKRDPSE----EIEILLRYGQHPNIIT 471
Query: 70 LFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129
L + ++ + L+ME G L L+ E E VL + M++L
Sbjct: 472 LKDVYDDG--KFVYLVMELMRGGEL---LDRILRQRYFSEREASDVLCTITKTMDYLHSQ 526
Query: 130 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERA 188
G+VHRD+KP NI+ ++ DFG A++L + ++ T ++ P++ +R
Sbjct: 527 GVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR- 585
Query: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKIITGK 241
+ Y A D+WS+G+ Y G PF P + P +E++ +I +GK
Sbjct: 586 -------QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTP---EEILARIGSGK 630
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 95.9 bits (237), Expect = 1e-19
Identities = 68/226 (30%), Positives = 114/226 (50%), Gaps = 23/226 (10%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74
+G+G+ V + +HK TG + AIK+F + MRE + LK+ +H+N+V L +
Sbjct: 10 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVF 69
Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSN-AYGLPESEFLIVLRDVVGGMNHLRENGIVH 133
+ H L+ EF +TVL+E + +GL L ++ +++L N I+H
Sbjct: 70 RQKKKIH--LVFEFID----HTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIH 123
Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVLRK 192
RDIKP NI+ + + G + KL DFG AR L + + T Y P++ VL+
Sbjct: 124 RDIKPENIL--VSQSG--ITKLCDFGFARTLAAPGDIYTDYVATRWYRAPEL----VLK- 174
Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238
YG VD+W++G ATG+ P+ + ++++KI+
Sbjct: 175 --DTSYGKPVDIWALGCMIIEMATGN----PYLPSSSDLDLLHKIV 214
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 95.9 bits (237), Expect = 1e-19
Identities = 68/226 (30%), Positives = 114/226 (50%), Gaps = 23/226 (10%)
Query: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74
+G+G+ V + +HK TG + AIK+F + MRE + LK+ +H+N+V L +
Sbjct: 10 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVF 69
Query: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSN-AYGLPESEFLIVLRDVVGGMNHLRENGIVH 133
+ H L+ EF +TVL+E + +GL L ++ +++L N I+H
Sbjct: 70 RQKKKIH--LVFEFID----HTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIH 123
Query: 134 RDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERAVLRK 192
RDIKP NI+ + + G + KL DFG AR L + + T Y P++ VL+
Sbjct: 124 RDIKPENIL--VSQSG--ITKLCDFGFARTLAAPGDIYTDYVATRWYRAPEL----VLK- 174
Query: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238
YG VD+W++G ATG+ P+ + ++++KI+
Sbjct: 175 --DTSYGKPVDIWALGCMIIEMATGN----PYLPSSSDLDLLHKIV 214
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/214 (33%), Positives = 107/214 (50%), Gaps = 14/214 (6%)
Query: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMR-EFEVLKKLNHKNIVKLF 71
++LG G V+ G+H+KTG AIKV + + F + Q+R E +L+ L+H IV L
Sbjct: 580 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLE 639
Query: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131
+ E T ++ME L +L S LPE ++ ++ + +L I
Sbjct: 640 CMFE--TPERVFVVMEKLHGDMLEMILS--SEKSRLPERITKFMVTQILVALRNLHFKNI 695
Query: 132 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191
VH D+KP N++ E V KL DFG AR + + S+ GT YL P+ VLR
Sbjct: 696 VHCDLKPENVLLASAEPFPQV-KLCDFGFARIIGEKSFRRSVVGTPAYLAPE-----VLR 749
Query: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 225
K Y ++D+WS+GV Y + +G+ PF E
Sbjct: 750 ---SKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 780
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,257,403
Number of Sequences: 37866
Number of extensions: 1158720
Number of successful extensions: 5536
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 508
Number of HSP's that attempted gapping in prelim test: 3714
Number of HSP's gapped (non-prelim): 1060
length of query: 729
length of database: 18,247,518
effective HSP length: 110
effective length of query: 619
effective length of database: 14,082,258
effective search space: 8716917702
effective search space used: 8716917702
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.