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Search of human proteins with 70166414
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 1065 0.0
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 837 0.0
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 835 0.0
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens] 770 0.0
gi|70166832 glutamate receptor, ionotropic, N-methyl D-aspartate... 233 4e-61
gi|21915167 glutamate receptor, ionotropic, N-methyl D-aspartate... 233 4e-61
gi|219689136 coiled-coil domain containing 68 [Homo sapiens] 120 2e-27
gi|13376818 coiled-coil domain containing 68 [Homo sapiens] 120 2e-27
gi|187607364 tuftelin 1 isoform 2 [Homo sapiens] 112 7e-25
gi|9910596 tuftelin 1 isoform 1 [Homo sapiens] 112 7e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 95 2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 95 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 95 2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 95 2e-19
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 84 4e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 82 2e-15
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 82 2e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 80 5e-15
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 80 5e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 80 5e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 79 1e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 79 1e-14
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 79 1e-14
gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens] 78 2e-14
gi|21735548 centrosomal protein 2 [Homo sapiens] 78 2e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens] 77 3e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 76 7e-14
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 76 9e-14
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 76 9e-14
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 76 9e-14
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 1065 bits (2755), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHH 480
VETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHH
Sbjct: 421 VETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHH 480
Query: 481 MPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRD 540
MPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRD
Sbjct: 481 MPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRD 540
Query: 541 EDDDWSSDEF 550
EDDDWSSDEF
Sbjct: 541 EDDDWSSDEF 550
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 837 bits (2162), Expect = 0.0
Identities = 435/435 (100%), Positives = 435/435 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLPR 435
VETREIGVGCDLLPR
Sbjct: 421 VETREIGVGCDLLPR 435
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 835 bits (2157), Expect = 0.0
Identities = 434/434 (100%), Positives = 434/434 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLP 434
VETREIGVGCDLLP
Sbjct: 421 VETREIGVGCDLLP 434
>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
Length = 438
Score = 770 bits (1989), Expect = 0.0
Identities = 406/434 (93%), Positives = 406/434 (93%), Gaps = 28/434 (6%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVE ENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVE----------------------------ENNELQSRLDYLTETQAKTE 392
Query: 421 VETREIGVGCDLLP 434
VETREIGVGCDLLP
Sbjct: 393 VETREIGVGCDLLP 406
>gi|70166832 glutamate receptor, ionotropic, N-methyl
D-aspartate-like 1A isoform 2 [Homo sapiens]
Length = 211
Score = 233 bits (593), Expect = 4e-61
Identities = 115/115 (100%), Positives = 115/115 (100%)
Query: 436 LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ 495
LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ
Sbjct: 97 LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ 156
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF 550
KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
Sbjct: 157 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF 211
>gi|21915167 glutamate receptor, ionotropic, N-methyl
D-aspartate-like 1A isoform 1 [Homo sapiens]
Length = 368
Score = 233 bits (593), Expect = 4e-61
Identities = 115/115 (100%), Positives = 115/115 (100%)
Query: 436 LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ 495
LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ
Sbjct: 254 LPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQ 313
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF 550
KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
Sbjct: 314 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF 368
>gi|219689136 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 120 bits (302), Expect = 2e-27
Identities = 93/333 (27%), Positives = 168/333 (50%), Gaps = 55/333 (16%)
Query: 89 VYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN 148
+Y +++ + EE Y+K +R TL+K+R +M+ D E+R S +H
Sbjct: 22 LYESTSAHIIEETEYVKKIRTTLQKIRTQMFKD--EIRHD--------STNHK------- 64
Query: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLRE 208
LD + N SDS ++ + + M K++
Sbjct: 65 --------LDAKHCGNLQQGSDS-------------------EMDPSCCSLDLLMKKIKG 97
Query: 209 KQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL- 267
K QL EN++LK+K+++S+EA A +R + ++L+ Y+ + +E ++K K+ L
Sbjct: 98 KDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQ 157
Query: 268 ---LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
LE+ + +E N Q AE LEEK +I EL+ L++RMEKE+ L + L E
Sbjct: 158 VNKLEKEQKLKQHVENLN---QVAE-KLEEKHSQITELENLVQRMEKEKRTLLERKLSLE 213
Query: 325 TEMSGELTDSDK--ERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
++ +L S + Q L+ + L+E+I HL ++H Q + ++ +++E+E LK L+
Sbjct: 214 NKLL-QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK 272
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
++ I L EK++ LE +N EL++++ +ET
Sbjct: 273 EQDKRIENLREKVNILEAQNKELKTQVALSSET 305
>gi|13376818 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 120 bits (302), Expect = 2e-27
Identities = 93/333 (27%), Positives = 168/333 (50%), Gaps = 55/333 (16%)
Query: 89 VYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN 148
+Y +++ + EE Y+K +R TL+K+R +M+ D E+R S +H
Sbjct: 22 LYESTSAHIIEETEYVKKIRTTLQKIRTQMFKD--EIRHD--------STNHK------- 64
Query: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLRE 208
LD + N SDS ++ + + M K++
Sbjct: 65 --------LDAKHCGNLQQGSDS-------------------EMDPSCCSLDLLMKKIKG 97
Query: 209 KQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL- 267
K QL EN++LK+K+++S+EA A +R + ++L+ Y+ + +E ++K K+ L
Sbjct: 98 KDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQ 157
Query: 268 ---LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
LE+ + +E N Q AE LEEK +I EL+ L++RMEKE+ L + L E
Sbjct: 158 VNKLEKEQKLKQHVENLN---QVAE-KLEEKHSQITELENLVQRMEKEKRTLLERKLSLE 213
Query: 325 TEMSGELTDSDK--ERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
++ +L S + Q L+ + L+E+I HL ++H Q + ++ +++E+E LK L+
Sbjct: 214 NKLL-QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK 272
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
++ I L EK++ LE +N EL++++ +ET
Sbjct: 273 EQDKRIENLREKVNILEAQNKELKTQVALSSET 305
>gi|187607364 tuftelin 1 isoform 2 [Homo sapiens]
Length = 365
Score = 112 bits (281), Expect = 7e-25
Identities = 64/182 (35%), Positives = 105/182 (57%), Gaps = 5/182 (2%)
Query: 240 EMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI 299
E +K KLQE +R+H ++ A + + + E++N +Q E +E+K+ +
Sbjct: 145 ESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEV 204
Query: 300 GELDRLIERMEKERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIR 354
GEL R + ME E L ++ E E E+ D +++E+ LE+ A LRE+I
Sbjct: 205 GELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIH 264
Query: 355 HLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
HLDDM+ QQ+KV+QM+E++++ K +Q K I +L EKI++LE EN E+ R+++L E
Sbjct: 265 HLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIE 324
Query: 415 TQ 416
Q
Sbjct: 325 KQ 326
Score = 37.0 bits (84), Expect = 0.047
Identities = 60/294 (20%), Positives = 125/294 (42%), Gaps = 29/294 (9%)
Query: 229 SSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK---EALLEETNSFLKAIEEANKKM 285
SS A + E+ + + +EE ++ + S +K E + + S ++ I+EA +
Sbjct: 30 SSHSAGHSLASELVES-HDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCL 88
Query: 286 QAAEISLEEKDQRIGELDR-LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEE 344
Q + K LDR L + + ++ Q+ L+ ++ L S E + E
Sbjct: 89 QKLREDISSK------LDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINE 142
Query: 345 ASASLRERIRHLDDMVHCQQKKVKQMVE------EIESLKKKLQQKQLLILQLLEKISFL 398
SLR+ ++ L + Q+ K + + + +++ +Q + + + +++
Sbjct: 143 DVESLRKTVQDL--LAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQK 200
Query: 399 EGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKS-GSPISSE 457
E E ELQ RL + + RE V + L R N++ ++ + + E
Sbjct: 201 EAEVGELQRRLLGMETEHQALLAKVREGEVALEEL-----RSNNADCQAEREKAATLEKE 255
Query: 458 ERRRRDK-QHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLA 510
R+K HLDD+ ++ + M QL + S A+ + + +E++ K+A
Sbjct: 256 VAGLREKIHHLDDMLKSQQRKVRQMIEQL---QNSKAVIQSKDATIQELKEKIA 306
>gi|9910596 tuftelin 1 isoform 1 [Homo sapiens]
Length = 390
Score = 112 bits (281), Expect = 7e-25
Identities = 64/182 (35%), Positives = 105/182 (57%), Gaps = 5/182 (2%)
Query: 240 EMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI 299
E +K KLQE +R+H ++ A + + + E++N +Q E +E+K+ +
Sbjct: 170 ESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEV 229
Query: 300 GELDRLIERMEKERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIR 354
GEL R + ME E L ++ E E E+ D +++E+ LE+ A LRE+I
Sbjct: 230 GELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIH 289
Query: 355 HLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
HLDDM+ QQ+KV+QM+E++++ K +Q K I +L EKI++LE EN E+ R+++L E
Sbjct: 290 HLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIE 349
Query: 415 TQ 416
Q
Sbjct: 350 KQ 351
Score = 37.0 bits (84), Expect = 0.047
Identities = 60/294 (20%), Positives = 125/294 (42%), Gaps = 29/294 (9%)
Query: 229 SSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK---EALLEETNSFLKAIEEANKKM 285
SS A + E+ + + +EE ++ + S +K E + + S ++ I+EA +
Sbjct: 55 SSHSAGHSLASELVES-HDGHEEIIKVYLKGRSGDKMIHEKNINQLKSEVQYIQEARNCL 113
Query: 286 QAAEISLEEKDQRIGELDR-LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEE 344
Q + K LDR L + + ++ Q+ L+ ++ L S E + E
Sbjct: 114 QKLREDISSK------LDRNLGDSLHRQEIQVVLEKPNGFSQSPTALYSSPPEVDTCINE 167
Query: 345 ASASLRERIRHLDDMVHCQQKKVKQMVE------EIESLKKKLQQKQLLILQLLEKISFL 398
SLR+ ++ L + Q+ K + + + +++ +Q + + + +++
Sbjct: 168 DVESLRKTVQDL--LAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQK 225
Query: 399 EGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKS-GSPISSE 457
E E ELQ RL + + RE V + L R N++ ++ + + E
Sbjct: 226 EAEVGELQRRLLGMETEHQALLAKVREGEVALEEL-----RSNNADCQAEREKAATLEKE 280
Query: 458 ERRRRDK-QHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLA 510
R+K HLDD+ ++ + M QL + S A+ + + +E++ K+A
Sbjct: 281 VAGLREKIHHLDDMLKSQQRKVRQMIEQL---QNSKAVIQSKDATIQELKEKIA 331
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 94.7 bits (234), Expect = 2e-19
Identities = 112/522 (21%), Positives = 225/522 (43%), Gaps = 55/522 (10%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1042
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1158
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1159 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1215 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1271 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSH 446
L + K+ LE E N LQ +LD E +AK +E + L + +DS
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERH--------ISTLNIQLSDSKKK 1379
Query: 447 CQKSGSPISS-EERRRRDKQHLDDIT------AARLLPLHHMPTQLLSIEESLAL----Q 495
Q S + + EE ++R ++ ++++T AA L +L + L + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYRE 537
+Q N E+ Q K Q LAE NI + + + RE
Sbjct: 1440 RQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEARE 1480
Score = 68.9 bits (167), Expect = 1e-11
Identities = 82/424 (19%), Positives = 178/424 (41%), Gaps = 44/424 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1014
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1067
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1068 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1115
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE 457
LEG ++LQ LD + K E + R++G + L DS++ Q+ + E
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 458 ---------ERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAK 508
E R + + ++ + + QL + + A + KQ E+ A
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 509 LAAQ 512
LA +
Sbjct: 1236 LAGE 1239
Score = 63.2 bits (152), Expect = 6e-10
Identities = 98/497 (19%), Positives = 186/497 (37%), Gaps = 79/497 (15%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKD-------VRATLEKVRKRMYGDYDEMRQKIRQLT 133
Q + ++ + QL+EE N ++D + LE+ + + ++K++
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 134 QELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIR 193
+ ++ + I+ + + A L LQ+ L D+ ++ N + +
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 194 NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE-ANAEVMREMTKKLYS----- 247
NL++ KQR+ + E + + K ++ A AE + TK L
Sbjct: 1445 NLEK-----------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 248 ---QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
+ +E+L+ + AE E L+ + K + E K +A E +EE ++ EL+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 305 LI-----------------------------ERMEKERHQLQLQLLEHETEMSGE----- 330
+ E+ E++R QLQ QL E+ETE+ E
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 331 --------LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L K+ Q + A E I+ L + Q ++K E+E +
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRD 1669
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+ + +K LE + +LQ L + + ++E E+ +L L R N
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE--ELASSLSGR-NA 1726
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQL---LSIEESLALQKQQK 499
++ + I+ E ++Q + + R+ QL L+ E S A + +
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 500 QNYEEMQAKLAAQKLAE 516
+ E Q K KL E
Sbjct: 1787 RQQLERQNKELRSKLHE 1803
Score = 56.6 bits (135), Expect = 6e-08
Identities = 57/293 (19%), Positives = 134/293 (45%), Gaps = 18/293 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1765 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1881
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQ 383
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL++
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLRR 1930
Score = 52.8 bits (125), Expect = 8e-07
Identities = 77/341 (22%), Positives = 145/341 (42%), Gaps = 42/341 (12%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--A 262
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 886
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E++ LL+E L+A E + + + L K Q + E+ +E +E QL
Sbjct: 887 EEKNLLQEQ---LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 943
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
+M+ ++ D + +QLEE A+ R++++ + KK++ + ++ KL
Sbjct: 944 ERKKMAQQMLDLE----EQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+++ L L E+IS L E + + LT+ + K E E+ V
Sbjct: 999 KERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-------------- 1041
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNY 502
+ EE+ R++ + L H L + L +Q +K+
Sbjct: 1042 ----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-- 1089
Query: 503 EEMQAKLAA--QKLAERLNIKMRSYNPEGESSGRYREVRDE 541
EE+QA LA ++A++ N + EG S ++ E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 94.7 bits (234), Expect = 2e-19
Identities = 112/522 (21%), Positives = 225/522 (43%), Gaps = 55/522 (10%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1049
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1165
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1166 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1222 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1278 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSH 446
L + K+ LE E N LQ +LD E +AK +E + L + +DS
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERH--------ISTLNIQLSDSKKK 1386
Query: 447 CQKSGSPISS-EERRRRDKQHLDDIT------AARLLPLHHMPTQLLSIEESLAL----Q 495
Q S + + EE ++R ++ ++++T AA L +L + L + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYRE 537
+Q N E+ Q K Q LAE NI + + + RE
Sbjct: 1447 RQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEARE 1487
Score = 68.9 bits (167), Expect = 1e-11
Identities = 82/424 (19%), Positives = 178/424 (41%), Gaps = 44/424 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 910
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1021
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1074
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1075 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1122
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE 457
LEG ++LQ LD + K E + R++G + L DS++ Q+ + E
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 458 ---------ERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAK 508
E R + + ++ + + QL + + A + KQ E+ A
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 509 LAAQ 512
LA +
Sbjct: 1243 LAGE 1246
Score = 63.2 bits (152), Expect = 6e-10
Identities = 98/497 (19%), Positives = 186/497 (37%), Gaps = 79/497 (15%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKD-------VRATLEKVRKRMYGDYDEMRQKIRQLT 133
Q + ++ + QL+EE N ++D + LE+ + + ++K++
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 134 QELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIR 193
+ ++ + I+ + + A L LQ+ L D+ ++ N + +
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 194 NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE-ANAEVMREMTKKLYS----- 247
NL++ KQR+ + E + + K ++ A AE + TK L
Sbjct: 1452 NLEK-----------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 248 ---QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
+ +E+L+ + AE E L+ + K + E K +A E +EE ++ EL+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 305 LI-----------------------------ERMEKERHQLQLQLLEHETEMSGE----- 330
+ E+ E++R QLQ QL E+ETE+ E
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 331 --------LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L K+ Q + A E I+ L + Q ++K E+E +
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRD 1676
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+ + +K LE + +LQ L + + ++E E+ +L L R N
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE--ELASSLSGR-NA 1733
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQL---LSIEESLALQKQQK 499
++ + I+ E ++Q + + R+ QL L+ E S A + +
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 500 QNYEEMQAKLAAQKLAE 516
+ E Q K KL E
Sbjct: 1794 RQQLERQNKELRSKLHE 1810
Score = 56.6 bits (135), Expect = 6e-08
Identities = 57/293 (19%), Positives = 134/293 (45%), Gaps = 18/293 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1772 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1888
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQ 383
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL++
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLRR 1937
Score = 52.8 bits (125), Expect = 8e-07
Identities = 77/341 (22%), Positives = 145/341 (42%), Gaps = 42/341 (12%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--A 262
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 893
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E++ LL+E L+A E + + + L K Q + E+ +E +E QL
Sbjct: 894 EEKNLLQEQ---LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 950
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
+M+ ++ D + +QLEE A+ R++++ + KK++ + ++ KL
Sbjct: 951 ERKKMAQQMLDLE----EQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+++ L L E+IS L E + + LT+ + K E E+ V
Sbjct: 1006 KERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-------------- 1048
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNY 502
+ EE+ R++ + L H L + L +Q +K+
Sbjct: 1049 ----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-- 1096
Query: 503 EEMQAKLAA--QKLAERLNIKMRSYNPEGESSGRYREVRDE 541
EE+QA LA ++A++ N + EG S ++ E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 94.7 bits (234), Expect = 2e-19
Identities = 112/522 (21%), Positives = 225/522 (43%), Gaps = 55/522 (10%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1049
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1165
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1166 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1222 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1278 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSH 446
L + K+ LE E N LQ +LD E +AK +E + L + +DS
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERH--------ISTLNIQLSDSKKK 1386
Query: 447 CQKSGSPISS-EERRRRDKQHLDDIT------AARLLPLHHMPTQLLSIEESLAL----Q 495
Q S + + EE ++R ++ ++++T AA L +L + L + Q
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYRE 537
+Q N E+ Q K Q LAE NI + + + RE
Sbjct: 1447 RQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEARE 1487
Score = 68.9 bits (167), Expect = 1e-11
Identities = 82/424 (19%), Positives = 178/424 (41%), Gaps = 44/424 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 910
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1021
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1074
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1075 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1122
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE 457
LEG ++LQ LD + K E + R++G + L DS++ Q+ + E
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 458 ---------ERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAK 508
E R + + ++ + + QL + + A + KQ E+ A
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 509 LAAQ 512
LA +
Sbjct: 1243 LAGE 1246
Score = 63.2 bits (152), Expect = 6e-10
Identities = 98/497 (19%), Positives = 186/497 (37%), Gaps = 79/497 (15%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKD-------VRATLEKVRKRMYGDYDEMRQKIRQLT 133
Q + ++ + QL+EE N ++D + LE+ + + ++K++
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 134 QELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIR 193
+ ++ + I+ + + A L LQ+ L D+ ++ N + +
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 194 NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE-ANAEVMREMTKKLYS----- 247
NL++ KQR+ + E + + K ++ A AE + TK L
Sbjct: 1452 NLEK-----------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 248 ---QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
+ +E+L+ + AE E L+ + K + E K +A E +EE ++ EL+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 305 LI-----------------------------ERMEKERHQLQLQLLEHETEMSGE----- 330
+ E+ E++R QLQ QL E+ETE+ E
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 331 --------LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L K+ Q + A E I+ L + Q ++K E+E +
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRD 1676
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+ + +K LE + +LQ L + + ++E E+ +L L R N
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE--ELASSLSGR-NA 1733
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQL---LSIEESLALQKQQK 499
++ + I+ E ++Q + + R+ QL L+ E S A + +
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 500 QNYEEMQAKLAAQKLAE 516
+ E Q K KL E
Sbjct: 1794 RQQLERQNKELRSKLHE 1810
Score = 56.2 bits (134), Expect = 7e-08
Identities = 57/292 (19%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1772 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1888
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL+
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLR 1936
Score = 52.8 bits (125), Expect = 8e-07
Identities = 77/341 (22%), Positives = 145/341 (42%), Gaps = 42/341 (12%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--A 262
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 893
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E++ LL+E L+A E + + + L K Q + E+ +E +E QL
Sbjct: 894 EEKNLLQEQ---LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 950
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
+M+ ++ D + +QLEE A+ R++++ + KK++ + ++ KL
Sbjct: 951 ERKKMAQQMLDLE----EQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+++ L L E+IS L E + + LT+ + K E E+ V
Sbjct: 1006 KERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-------------- 1048
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNY 502
+ EE+ R++ + L H L + L +Q +K+
Sbjct: 1049 ----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-- 1096
Query: 503 EEMQAKLAA--QKLAERLNIKMRSYNPEGESSGRYREVRDE 541
EE+QA LA ++A++ N + EG S ++ E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 94.7 bits (234), Expect = 2e-19
Identities = 112/522 (21%), Positives = 225/522 (43%), Gaps = 55/522 (10%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1042
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1158
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1159 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1215 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1271 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSH 446
L + K+ LE E N LQ +LD E +AK +E + L + +DS
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERH--------ISTLNIQLSDSKKK 1379
Query: 447 CQKSGSPISS-EERRRRDKQHLDDIT------AARLLPLHHMPTQLLSIEESLAL----Q 495
Q S + + EE ++R ++ ++++T AA L +L + L + Q
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 496 KQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYRE 537
+Q N E+ Q K Q LAE NI + + + RE
Sbjct: 1440 RQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEARE 1480
Score = 68.9 bits (167), Expect = 1e-11
Identities = 82/424 (19%), Positives = 178/424 (41%), Gaps = 44/424 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1014
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1067
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1068 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1115
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE 457
LEG ++LQ LD + K E + R++G + L DS++ Q+ + E
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 458 ---------ERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAK 508
E R + + ++ + + QL + + A + KQ E+ A
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 509 LAAQ 512
LA +
Sbjct: 1236 LAGE 1239
Score = 63.2 bits (152), Expect = 6e-10
Identities = 98/497 (19%), Positives = 186/497 (37%), Gaps = 79/497 (15%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKD-------VRATLEKVRKRMYGDYDEMRQKIRQLT 133
Q + ++ + QL+EE N ++D + LE+ + + ++K++
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 134 QELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIR 193
+ ++ + I+ + + A L LQ+ L D+ ++ N + +
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 194 NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE-ANAEVMREMTKKLYS----- 247
NL++ KQR+ + E + + K ++ A AE + TK L
Sbjct: 1445 NLEK-----------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 248 ---QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
+ +E+L+ + AE E L+ + K + E K +A E +EE ++ EL+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 305 LI-----------------------------ERMEKERHQLQLQLLEHETEMSGE----- 330
+ E+ E++R QLQ QL E+ETE+ E
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 331 --------LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L K+ Q + A E I+ L + Q ++K E+E +
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL----QAQMKDFQRELEDARASRD 1669
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+ + +K LE + +LQ L + + ++E E+ +L L R N
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE--ELASSLSGR-NA 1726
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQL---LSIEESLALQKQQK 499
++ + I+ E ++Q + + R+ QL L+ E S A + +
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 500 QNYEEMQAKLAAQKLAE 516
+ E Q K KL E
Sbjct: 1787 RQQLERQNKELRSKLHE 1803
Score = 56.2 bits (134), Expect = 7e-08
Identities = 57/292 (19%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1765 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1881
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL+
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLR 1929
Score = 52.8 bits (125), Expect = 8e-07
Identities = 77/341 (22%), Positives = 145/341 (42%), Gaps = 42/341 (12%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--A 262
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 886
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E++ LL+E L+A E + + + L K Q + E+ +E +E QL
Sbjct: 887 EEKNLLQEQ---LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA 943
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
+M+ ++ D + +QLEE A+ R++++ + KK++ + ++ KL
Sbjct: 944 ERKKMAQQMLDLE----EQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQND 442
+++ L L E+IS L E + + LT+ + K E E+ V
Sbjct: 999 KERKL---LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-------------- 1041
Query: 443 SSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNY 502
+ EE+ R++ + L H L + L +Q +K+
Sbjct: 1042 ----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE-- 1089
Query: 503 EEMQAKLAA--QKLAERLNIKMRSYNPEGESSGRYREVRDE 541
EE+QA LA ++A++ N + EG S ++ E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 83.6 bits (205), Expect = 4e-16
Identities = 96/402 (23%), Positives = 175/402 (43%), Gaps = 50/402 (12%)
Query: 43 EQCEKKIERKEQLLDLSNGEPTR---------KLPQGVVYGVVRRSDQNQQKEMVVYGWS 93
E +KKI + E+ L + TR + + R+ + N +K VY
Sbjct: 565 EDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK---VYAEM 621
Query: 94 TSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ 153
Q+++ + ++ EK K +++RQ+ Q EL + H Q++
Sbjct: 622 KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK--------- 672
Query: 154 SSALDRFNAMNSALASDSI----GLQKTLVDVTLENSN----IKDQIRNLQQTYEASMDK 205
+ L + NA +L D L+K L +E+ N K + + EA + K
Sbjct: 673 THLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHK 732
Query: 206 LREKQRQLEVAQVENQLLKM---KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSA 262
LRE+ + +Q + QL+++ + E Q A E + KL ++ E+ E ++ H+A
Sbjct: 733 LREELINVN-SQRKQQLVELGLLREEEKQRATRE-HEIVVNKLKAESEKMKIELKKTHAA 790
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E E LE+ NS LK IE+ + L + Q I EL I +++E Q QL
Sbjct: 791 ETEMTLEKANSKLKQIEKEYTQ------KLAKSSQIIAELQTTISSLKEENSQQQLAAER 844
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK----QMVEEIESLK 378
++ + D K+ + ++A L++ + + + V C +KK++ + E+I ++
Sbjct: 845 RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIR 904
Query: 379 KKLQQK------QLLILQLLEKISFLEGENNELQSRLDYLTE 414
++ + K L +L + IS L+ + N LQ R L E
Sbjct: 905 QEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQE 946
Score = 53.5 bits (127), Expect = 5e-07
Identities = 74/361 (20%), Positives = 156/361 (43%), Gaps = 63/361 (17%)
Query: 100 EMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDR 159
E+ +K R TL K + + DY E K+ Q + ++ +QE+
Sbjct: 451 ELQEVKARRNTLHKEKDHLVNDY-EQNMKLLQTKYDADINLLKQEH-------------- 495
Query: 160 FNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE 219
A++++ AS I LE N+ + LQ++ +LR+++ + ++ +
Sbjct: 496 --ALSASKASSMIE--------ELEQ-NVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544
Query: 220 NQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEE----------QRKHSAEKEALLE 269
+ + K ++ + +E T+K ++EE L+E+ QR + + +A LE
Sbjct: 545 LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALE 604
Query: 270 ETNSFL-----KAIEEANKKMQAAEI------SLEEKDQR--IGELDRLIERMEKERHQL 316
E + K E ++M+ E SL EK + + +L+ + +R E++ +L
Sbjct: 605 EFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
Query: 317 QLQLLEHETEMSGELTDSDKER-------YQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
+ LEHE E + L + E+ +++E LR ++ + +K+ Q
Sbjct: 665 K---LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ 721
Query: 370 MVEEIESLKKKLQQKQLLI----LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
++ ++E+ KL+++ + + Q L ++ L E + +R + + K E E +
Sbjct: 722 VIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMK 781
Query: 426 I 426
I
Sbjct: 782 I 782
Score = 52.0 bits (123), Expect = 1e-06
Identities = 83/396 (20%), Positives = 165/396 (41%), Gaps = 46/396 (11%)
Query: 174 LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK-QRQLEVAQV-----ENQLLKMKV 227
+QK L E +K R+ Q E ++ KL +K Q + QV E+Q+ ++K
Sbjct: 283 VQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK- 341
Query: 228 ESSQEANAEVMREMTKKLYSQYEEKLQEE---QRKHSAEKEALLEETNSFLKAIE-EANK 283
+ +++ + + KKL++ E QE+ Q++H+ + LLE+TN L +E E
Sbjct: 342 KICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMA 401
Query: 284 KMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLE 343
+ Q+ ++E + R+ +L E E LQ Q L E K ++
Sbjct: 402 QTQSTNHMIKELEARVQQLTG-----EAENSNLQRQKLIQE-----------KAELERCY 445
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENN 403
+ + S + ++ + +H K+ +V + E K LQ K + LL++ L +
Sbjct: 446 QITCSELQEVKARRNTLH---KEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSA--S 500
Query: 404 ELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRD 463
+ S ++ L + + + + +E +L + R ++ +KS E++
Sbjct: 501 KASSMIEELEQNVCQLKQQLQE----SELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDL 556
Query: 464 KQHLDDITAARLLPLHHMPTQLLSIEESLA----LQKQQKQNYE------EMQAKLAAQK 513
+ LD +H L EE L +Q+ Q Q + + Q +L ++K
Sbjct: 557 QSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK 616
Query: 514 LAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDE 549
+ + +M + S RE + ++ W ++
Sbjct: 617 VYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLED 652
Score = 49.7 bits (117), Expect = 7e-06
Identities = 66/302 (21%), Positives = 127/302 (42%), Gaps = 50/302 (16%)
Query: 242 TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFL---------------KAIEEANKKMQ 286
TK + +++ E+ + Q+KH A+ + +LE N+ + + I + KK+Q
Sbjct: 261 TKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQ 320
Query: 287 A----AEISLEEKDQRIGELDRLIER-MEKERHQLQLQLLEHETEMSGELTDSDKERYQQ 341
++ E K+ +I EL ++ E+ E + + +L EM E D K+ +
Sbjct: 321 TLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTEN 380
Query: 342 LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGE 401
++E R+ ++ Q + M++E+E+ ++L E E
Sbjct: 381 IQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTG---------------EAE 425
Query: 402 NNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRR 461
N+ LQ + Q K E+E R + C L + R+N + H +K E+ +
Sbjct: 426 NSNLQRQ----KLIQEKAELE-RCYQITCSELQEVKARRN--TLHKEKDHLVNDYEQNMK 478
Query: 462 RDKQHLD-DITAAR---LLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAER 517
+ D DI + L + + +E+++ KQQ Q E+Q K Q+L ++
Sbjct: 479 LLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQE-SELQRK---QQLRDQ 534
Query: 518 LN 519
N
Sbjct: 535 EN 536
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 81.6 bits (200), Expect = 2e-15
Identities = 104/514 (20%), Positives = 226/514 (43%), Gaps = 63/514 (12%)
Query: 94 TSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ 153
+SQL EE K++ A + ++ M D +E +K + QEL + + + +Q Q
Sbjct: 1012 SSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 154 SSALD-RFNAMNSALASDSIGLQKTLV---DVTLENSN-------IKDQIRNLQQTYEAS 202
+ L + + + LA LQ L D TL +N ++ QI LQ+ +E+
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 203 MDKLREKQRQLEVAQVENQLLKMKVESSQEANA--EVMREMTKKLYSQYEEKLQEEQRKH 260
+ ++Q E + LK ++E + + A + +R ++ ++ ++ L+EE + H
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 261 SAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELD--------RLIERMEKE 312
A+ + + + + L+ + E ++ + + +LE+ Q + E D +++++++ E
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-ETDNKELACEVKVLQQVKAE 1249
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVE 372
+ +L E+ ++++ D+ R + E+AS L+ + ++ ++ +KK + +
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS-KLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 373 EIESLKKKLQQKQLLI-------LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ SL+ +LQ Q L+ L L +I LE E N LQ + + E +A+ +E +
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE--EEEEARKNLEKQV 1366
Query: 426 IGVGCDLLPRLPFRQND---------SSSHCQKSGSPISS------------EERRRRDK 464
+ + L +D + K +S E+ + R +
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 465 QHLDDIT---------AARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLA 515
Q LDD+T A+ L QLL+ E+S++ + ++++ E +A+ K
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 516 ERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDE 549
+ + E + +++R + +D S +
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Score = 66.2 bits (160), Expect = 7e-11
Identities = 97/495 (19%), Positives = 215/495 (43%), Gaps = 80/495 (16%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSS 155
+L E++ K +A LEK ++ + D E+ +++ L Q + S +++ L+ +Q +
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266
Query: 156 ALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEV 215
+ + + LA + LQ L D + L + E K + LE
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNEL-----------DNVSTLLEEAEKKGIKFAKDAASLE- 1314
Query: 216 AQVENQLLKMKVESSQEAN-AEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL------- 267
+Q+++ ++ E+ Q+ N + +R++ ++ S E++ +EE+ + + EK+ L
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 268 -----LEETNSFLKAIEEANKKM----QAAEISLEEKDQRIGELDRLIERMEKERHQLQL 318
+++ ++++EEA KK+ +A LEEK +L++ R+++E L +
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 319 QLLEHETEMSGELTDSDKE-------------RY-QQLEEASASLRER-------IRHLD 357
L+H+ +++ L K+ RY ++ + A A RE+ R L+
Sbjct: 1435 D-LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 358 DMVHCQ---QKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
+ + + +++ KQ+ ++E L + +L + LE + E++++L+ L +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 415 TQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAAR 474
TE + V + + F ++ + Q ++ R + L+D R
Sbjct: 1554 ELQATEDAKLRLEVNMQAM-KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 475 LLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQ--------KLAERLNIKMRSYN 526
L ++A +K+ + + ++++A++ A K +L +M+ Y
Sbjct: 1613 AL--------------AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 527 PEGESSGRYREVRDE 541
E E + R RDE
Sbjct: 1659 RELEEA---RASRDE 1670
Score = 63.9 bits (154), Expect = 4e-10
Identities = 66/316 (20%), Positives = 148/316 (46%), Gaps = 41/316 (12%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EE+ + +++ + ++ G+ +EM +K +QL +E ++ L +Q ++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI-------LAEQLQAETELF 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDV--TLENSNIKDQI-RNLQQTYEASMDKLREKQRQLE 214
M + LA+ L++ L D+ +E ++QI +N ++ +A + L E+ + E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 215 VAQVENQLLKMKVESS-----------QEANAEVMRE--MTKKLYSQYEEKLQEEQRKHS 261
A+ + QL K+ E+ ++ N++ ++E + + ++ +L EE+ K
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 262 ------AEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQ 315
++E ++ + LK E+ ++++ A+ L D +L I ++ + +
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL---DGETTDLQDQIAELQAQIDE 1080
Query: 316 LQLQLLEHETEMSGELTDSDKER---------YQQLEEASASLRERIRHLDDMVHCQQKK 366
L+LQL + E E+ G L D E ++L+ A L+E + +K+
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 367 VKQMVEEIESLKKKLQ 382
+ + EE+E+LK +L+
Sbjct: 1141 KRDLSEELEALKTELE 1156
Score = 59.7 bits (143), Expect = 7e-09
Identities = 83/477 (17%), Positives = 201/477 (42%), Gaps = 63/477 (13%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKI----RQLTQELSVSHAQQEYLENHIQ 151
QL+EE N +++ + E+ RK + ++ ++ +++ +L + +E + ++
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 152 TQSSALDRFNAMNSALASDSIG-----LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKL 206
+ R ALA D + LQ+ L D+T++ + + NL++ + D+L
Sbjct: 1400 DAEALSQRLE--EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-QKKFDQL 1456
Query: 207 REKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS--------QYEEKLQEEQR 258
+++ + E + A AE + TK L + +E+ + + +
Sbjct: 1457 LAEEKSISARYAEER---------DRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 259 KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQL 318
+ A+ E L+ + K + E K +A E +EE ++ EL+ ++ E + +L++
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 319 QLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKK-------VKQMV 371
+ + + +L D +Q EE L +++R L+ + ++K+ K+M
Sbjct: 1568 NMQAMKAQFERDLQTRD----EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 372 EEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCD 431
+++ L+ +++ ++++++ L+ + + Q L+ ++ + +++E
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 432 LLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDIT----------AARLLPLHHM 481
L + Q SSE RR +Q D++ +A L +
Sbjct: 1684 SL---------EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734
Query: 482 PTQLLSIEESLALQKQQKQNYEEMQAKLAAQKL-AERLNIKMRSYNPEGESSGRYRE 537
++ +EE L ++++ N E + + L + LN ++ + + S R+
Sbjct: 1735 EARIAQLEEEL---EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788
Score = 53.1 bits (126), Expect = 6e-07
Identities = 71/350 (20%), Positives = 145/350 (41%), Gaps = 58/350 (16%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVS-----HAQQEYL 146
+Q+K+ +++ RA+ +++ K + +I QL +EL+ S HA+QE
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 147 E------NHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKD---QIRNLQQ 197
E N +S+ LD + + +A L++ ++ L N + Q+ L
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 198 TYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS---QYEEKLQ 254
A ++ + + +N+ LK K++ + A + L + Q EE+L+
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
+E ++ +A K + KK++ + +E++ + + +E+
Sbjct: 1832 QEAKERAAAN-----------KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEI 374
QL+ QL E E E + A+AS R+ R LDD + + E+
Sbjct: 1881 QLKRQLEEAEEEAT---------------RANASRRKLQRELDDATEANE----GLSREV 1921
Query: 375 ESLKKKLQQKQLLIL--------QLLEKISFLEGENNELQSRLDYLTETQ 416
+LK +L++ + QL + + LE +++ +S+ + ETQ
Sbjct: 1922 STLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
Score = 47.8 bits (112), Expect = 3e-05
Identities = 52/255 (20%), Positives = 119/255 (46%), Gaps = 27/255 (10%)
Query: 176 KTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
K L+ VT + + Q + + K++EKQ ++E E + ++ + A
Sbjct: 842 KPLLQVTRQEEEL--------QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA 893
Query: 236 EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEK 295
E ++ T+ L+++ EE + + +A+K+ L E + +EE ++ Q + ++
Sbjct: 894 EQLQAETE-LFAEAEEM----RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 296 DQRIGELDRLIERMEKERHQLQLQLLEHET---EMSGELTDSDKERYQQLEEASASLRER 352
I +L+ ++ E R +LQL+ + E +M E+ + + + ++E + +R
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-MEDR 1007
Query: 353 IRHLDDMVHCQQKKVKQMVE-------EIESLKKKLQQKQLLILQLLEKISFLEGENNEL 405
I + +++K K + + I L+++L++++ +L + L+GE +L
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 406 QSRLDYLTETQAKTE 420
Q D + E QA+ +
Sbjct: 1068 Q---DQIAELQAQID 1079
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 81.6 bits (200), Expect = 2e-15
Identities = 111/487 (22%), Positives = 208/487 (42%), Gaps = 42/487 (8%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQ-LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ 134
V R +Q + +E+ + Q L+ + + + LE+ + + ++++++ QL++
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
+LS + E Q Q AL+R ALA + GL LV E + ++
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 195 LQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
L+ EA L E QRQL AQ+E + + ++E+ +A +T +L + +++
Sbjct: 902 LRLEKEALEGSLFEVQRQL--AQLEAR--REQLEAEGQALLLAKETLTGEL-AGLRQQII 956
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI-GELDRLIERMEKER 313
Q K S +KE + ++ ++A EA ++ + EE QR+ E + +E ER
Sbjct: 957 ATQEKASLDKELMAQK---LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 314 HQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE 373
QLQ QL + E+ L + E+ + EE +A +ER D+ + + + +Q +
Sbjct: 1014 AQLQSQLQREQEELLARL---EAEKEELSEEIAALQQER----DEGLLLAESEKQQALSL 1066
Query: 374 IESLKKKLQQKQLLILQLLEKISF-LEGENNELQSRLDYLTETQAKTEVETREIGVGCDL 432
ES K L +K + L IS +E + + QSR + T E R++
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQ--- 1123
Query: 433 LPRLPFRQNDSSSHCQ--------------KSGSPISSEERRRRDKQHLDDITAARLLPL 478
R+ +++H Q + S + E R + L+D L
Sbjct: 1124 ------REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRREL 1177
Query: 479 HHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLA-ERLNIKMRSYNPEGESSGRYRE 537
+L +E +Q+Q+ + A ++ A R N ++RS + ES +
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLK 1237
Query: 538 VRDEDDD 544
+ +ED +
Sbjct: 1238 LANEDKE 1244
Score = 71.6 bits (174), Expect = 2e-12
Identities = 97/466 (20%), Positives = 200/466 (42%), Gaps = 56/466 (12%)
Query: 105 KDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT-QSSALDRFNAM 163
++ +A+L + R D ++++ +EL AQ L++ +Q Q L R A
Sbjct: 978 REAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQ---LQSQLQREQEELLARLEAE 1034
Query: 164 NSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASM-DKLREKQRQLEVAQVENQL 222
L+ + LQ+ + L + K Q +L+++ + ++ +KL + L +E +
Sbjct: 1035 KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER 1094
Query: 223 LKMKVESSQEANAEVMREMTKKL-------------YSQYEEKLQEEQRKHSAEKEALL- 268
K +S QE + + +T +L ++Q +LQE+ R ++++ L
Sbjct: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR 1154
Query: 269 --EETNSFLKAIE-----------EANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQ 315
EE + L+ +E EA +K++ ++ E + Q GEL R + KER
Sbjct: 1155 EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 316 LQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIE 375
L+ E+ + ++ ER L+ A+ +++ L++ K+ ++ ++
Sbjct: 1215 LR----RSNEELRSAVKKAESERIS-LKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
Query: 376 SLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQA---KTEVETREIGVGCDL 432
+++ + + + +L ++ L+ EN L L L A + E E+R +G
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGL-- 1327
Query: 433 LPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESL 492
R + ++S + ++ +R+ +Q + T R L L S+EE+
Sbjct: 1328 --RQRLLKGEASLEVMRQELQVA---QRKLQEQEGEFRTRERRL--------LGSLEEAR 1374
Query: 493 ALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREV 538
+KQQ + ++ KL A + AE + +R EG + G E+
Sbjct: 1375 GTEKQQLDHARGLELKLEAAR-AEAAELGLRLSAAEGRAQGLEAEL 1419
Score = 70.5 bits (171), Expect = 4e-12
Identities = 93/453 (20%), Positives = 184/453 (40%), Gaps = 31/453 (6%)
Query: 75 VVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ 134
++ R N + V +L++E ++ + L + R R+ + ++ Q ++ +
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNI---KDQ 191
EL SH Q E LE S LA + + +++ L TL+ + K +
Sbjct: 660 ELERSHRQLEQLEGK--------------RSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 192 IRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE 251
+ EA +L +L + Q K+ + E+ A+ ++ + + EE
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 252 KLQEEQRKHSAEKEALL--EETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERM 309
K + R+ AE+EA + EE + E Q E SL +Q L++ + +
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 310 EKERHQLQLQLLEHETEMSG---ELTDSDKERYQQLEEASASLRER------IRHLDDMV 360
ER QLQ QL + ++SG EL + +E +Q+E + RE+ L +
Sbjct: 826 RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL 885
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
+++ + + EE L+ + + + + ++ +++ LE +L++ L AK
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL--LLAKET 943
Query: 421 VETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHH 480
+ G+ ++ D QK + R+++ + RL
Sbjct: 944 LTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKE 1003
Query: 481 MPTQLLSIEESLALQKQQKQNYEEMQAKLAAQK 513
+ L E + LQ Q ++ EE+ A+L A+K
Sbjct: 1004 AAWRELEAERA-QLQSQLQREQEELLARLEAEK 1035
Score = 62.0 bits (149), Expect = 1e-09
Identities = 52/295 (17%), Positives = 131/295 (44%), Gaps = 14/295 (4%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
++++E ++D L + + + R K L + L+ ++ L+ +
Sbjct: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR 1774
Query: 155 SALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLE 214
AL +S+L L+ + D+ L+ + Q++ L++ + ++
Sbjct: 1775 QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ 1834
Query: 215 VAQVENQLLKMKVESSQEANAEV---MREMTKKLYSQYEEKLQEEQRKHSAEKEALLEET 271
Q E +LL+ ++ S Q A A++ RE+ + ++++ + E+E L
Sbjct: 1835 KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE 1894
Query: 272 NSFLKAIEEA--NKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSG 329
++ + E+ ++ + AE+ L E ++I +L+ + +E+ QL++ + ++
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-- 1952
Query: 330 ELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQK 384
E Q++E ++ + R L+ +++V+ + E++ +LK +LQQ+
Sbjct: 1953 -------ELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000
Score = 59.3 bits (142), Expect = 9e-09
Identities = 78/356 (21%), Positives = 156/356 (43%), Gaps = 35/356 (9%)
Query: 168 ASDSIG-LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMK 226
+ D +G L+K L D E +++Q++ L+ + +M + QR+++ + N+LL +
Sbjct: 545 SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-R 603
Query: 227 VESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQ 286
+S+ + +V ++ ++L Q EKLQ Q + +++ L EE ++ ++++
Sbjct: 604 EKSNLAHSLQVAQQQAEEL-RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
Query: 287 AAEISLEEKDQRIGELDR-LIE-RMEKERHQLQLQLLEHE-TEMSGELTDSDKERYQQLE 343
+ LE+ + + L + L+E R R LQ +L+ E E++ LT ++ R +LE
Sbjct: 663 RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRV-ELE 721
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQL----LILQLLEKISFLE 399
+ LR ++ ++ + ++ +L + L Q +L L+ QL E+ S L+
Sbjct: 722 LSMTKLR-----------AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770
Query: 400 GENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEER 459
G + + E Q + E E V L R + + + P ER
Sbjct: 771 GRQRQAEQEATVAREEQERLEELRLEQEVARQGLEG-SLRVAEQAQEALEQQLPTLRHER 829
Query: 460 RRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLA 515
+ +Q L + QL E+ L +++ Q E + A +K A
Sbjct: 830 SQLQEQ------------LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA 873
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 58/370 (15%)
Query: 106 DVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHA-------QQEYLENHIQTQSSALD 158
++RA+ EK+ K M + ++ R+L + L S + Q+ LE +Q L
Sbjct: 1615 ELRASQEKISK-MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 159 RFNAMNSALASDSIGLQKTLVD---------VTLENSN------------IKDQIRNLQQ 197
A AL LQ+ + D +T+E N ++D++R L +
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 198 TY---EASMDKLREK----QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYE 250
AS++ R+K Q+ L + + Q+L+ +++++++A +E +K S
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA-----RKQSSSLG 1788
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
E++Q R A+ E E L+ + E ++ Q E + Q++ + RL++
Sbjct: 1789 EQVQT-LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847
Query: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
+ QL + E+ +K+R RE++R +D V +K ++
Sbjct: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEK-GRL 1906
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENN-------------ELQSRLDYLTETQA 417
+ + +L + Q I QL ++ LE ++ ELQ ++ L QA
Sbjct: 1907 DRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQA 1966
Query: 418 KTE--VETRE 425
+TE +E RE
Sbjct: 1967 QTERTLEARE 1976
Score = 52.8 bits (125), Expect = 8e-07
Identities = 91/462 (19%), Positives = 191/462 (41%), Gaps = 53/462 (11%)
Query: 58 LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKR 117
++ E R+ G + GV Q E+ + S + + E D ATLE+ +
Sbjct: 1560 VAESEEARRSVDGRLSGV--------QAELALQEESVRRSERERRATLDQVATLERSLQA 1611
Query: 118 MYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKT 177
+ ++KI ++ + + L+ + S + +L + +
Sbjct: 1612 TESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG 1671
Query: 178 LVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEV 237
L D + ++D++ +LQ+ + + +++ QL V ++ L KVE S+ A +
Sbjct: 1672 LSDREAQAQALQDRVDSLQR--QVADSEVKAGTLQLTVERLNGAL--AKVEESEGALRDK 1727
Query: 238 MREMTKKLYSQYEEKLQEEQRKHSAEKEAL--LEETNSFLKAIEEANKKMQAAEISLEEK 295
+R +T+ L +Q L + K+ ++AL E L+ +++ AA +L E
Sbjct: 1728 VRGLTEAL-AQSSASLNSTRDKNLHLQKALTACEHDRQVLQ------ERLDAARQALSEA 1780
Query: 296 DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRH 355
++ L ++ + E L+LQ +E E ++ +E +Q +E A+ ++
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQL-----QQLREVLRQRQEGEAAALNTVQK 1835
Query: 356 LDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
L D ++++ Q E + SL++ L Q + ++ LE + L+ LD +
Sbjct: 1836 LQD-----ERRLLQ--ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
Query: 416 QAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARL 475
+ ++ +T + L R +G+ + E +R+ +Q + +
Sbjct: 1889 KLRSHEDTVRLSAEKGRLDR------------TLTGAELELAEAQRQIQQLEAQVV---V 1933
Query: 476 LPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAER 517
L H P QL + Q+QQ + +E++ +AQ ER
Sbjct: 1934 LEQSHSPAQL-----EVDAQQQQLELQQEVERLRSAQAQTER 1970
Score = 52.4 bits (124), Expect = 1e-06
Identities = 102/512 (19%), Positives = 199/512 (38%), Gaps = 95/512 (18%)
Query: 78 RSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELS 137
R++ +K+ ++ QL++++ KD+ +++M D D+ R L+
Sbjct: 352 RAEAALEKQALLQAQLEEQLRDKVLREKDL------AQQQMQSDLDKADLSARVTELGLA 405
Query: 138 VSHAQQEYLENHIQTQSSALDRFNAMNSAL--------ASDSIGLQKTLVDVT---LENS 186
V +++ LE Q ++ A+ S D GLQ+TL D+ L +S
Sbjct: 406 VKRLEKQNLEKD-QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDS 464
Query: 187 NIKDQIRNLQQTYEASMDKLREKQRQ---------------------------------L 213
Q+ ++T +AS LR Q +
Sbjct: 465 ESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI 524
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
A + QL + EA+ +++ + K+L + E+R + + L ++T+
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDS-----ESERRALEEQLQRLRDKTDG 579
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
++A E+A +++Q R+ + L+ R EK LQ+ + + E EL
Sbjct: 580 AMQAHEDAQREVQ-----------RLRSANELLSR-EKSNLAHSLQVAQQQAE---ELRQ 624
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLE 393
++E+ Q +E R+R+ +++ + V++ ++++L++ + QL
Sbjct: 625 -EREKLQAAQEELRRQRDRL----------EEEQEDAVQDGARVRRELERSHRQLEQLEG 673
Query: 394 KISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSP 453
K S L E E++ L T + + E E+ + + S +
Sbjct: 674 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALT-------KAEAGRVELELSMTK 726
Query: 454 ISSEERRRRDK----QHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKL 509
+ +EE +D L++ A L L+ + QL EE ALQ +Q+Q +E
Sbjct: 727 LRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE--EEKSALQGRQRQAEQEATVAR 784
Query: 510 AAQKLAERLNIKMRSYNPEGESSGRYREVRDE 541
Q+ E L ++ E S R E E
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Score = 50.4 bits (119), Expect = 4e-06
Identities = 83/355 (23%), Positives = 148/355 (41%), Gaps = 60/355 (16%)
Query: 111 LEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQE-----YLENHIQTQSSALDRFNAMNS 165
+E+ ++ ++ R + LT EL AQ+E + + + Q A D +S
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151
Query: 166 ALA-SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE-NQLL 223
L ++ + Q L++ + +D +R ++ EA KLRE Q EV + E +L
Sbjct: 1152 CLREAEELRTQLRLLE------DARDGLR--RELLEAQR-KLRESQEGREVQRQEAGELR 1202
Query: 224 KMKVESSQEANA-----EVMREMTKKLYSQ-YEEKLQEEQRKHSAEKEALLEETNSFL-K 276
+ E ++E A E +R KK S+ KL E ++ +K ALLEE + + K
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE---QKLALLEEARTAVGK 1259
Query: 277 AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMS-GELTDSD 335
E +Q E S E + + EL R ++ ++ E +L +L E + ++ GE + +
Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
Query: 336 KER--------------------------YQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
R ++L+E R R R L + + KQ
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
Query: 370 MVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
++ L+ KL+ + +L ++S EG L++ L A+ EV+ R
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL-------ARVEVQRR 1427
Score = 45.8 bits (107), Expect = 1e-04
Identities = 99/446 (22%), Positives = 192/446 (43%), Gaps = 56/446 (12%)
Query: 146 LENHIQT-QSSALDRFNAMNSA-LASDS--IGLQKTLVDVTLENSNIKDQIRNLQQTYEA 201
LE IQT +SS L + + + LA D+ L + ++ N + + L T A
Sbjct: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMA 74
Query: 202 SMDKLREKQR--QLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEE 256
S+ L+E+ + Q E+++VE+ L + + E + A NA V + + L + E +E
Sbjct: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNA-VSERLEQALRLEPGELETQE 133
Query: 257 QR---KHSAE-KEALLEETNSF---LKAIEEANKK----MQAAEISLEEKDQRIGELDRL 305
R + S E + L EE S+ L+A +E ++ +Q + + + +R EL++
Sbjct: 134 PRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQ 193
Query: 306 IERMEKERHQLQLQLLEHETEMSGEL--TDSDKERYQQLEEASASLRERIRHLDDMVHCQ 363
+ E Q +L+ EH ++ L + +++R L + +A LRE++
Sbjct: 194 LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQAL 253
Query: 364 QKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNE----------------LQS 407
+ ++++ + +K+L+ ++ + E+ SF +NE L S
Sbjct: 254 SEDIRKVTNDWTRCRKELEHREAAWRR--EEESFNAYFSNEHSRLLLLWRQVVGFRRLVS 311
Query: 408 RLDYLTETQ--------AKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEER 459
+ TE A+T +E G+G L L ++ + + +K + E
Sbjct: 312 EVKMFTERDLLQLGGELARTSRAVQEAGLG--LSTGLRLAESRAEAALEKQALLQAQLEE 369
Query: 460 RRRDKQHLDDITAARLL--PLHHMPTQLLSIEESLALQKQQKQNYEEMQA-KLAAQKL-- 514
+ RDK + A + + L E LA+++ +KQN E+ Q K +KL
Sbjct: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
Query: 515 AERLNIKMRSYNPEGESSGRYREVRD 540
E L ++ ++ + G + +RD
Sbjct: 430 LESLRLQEQAALETEDGEGLQQTLRD 455
Score = 40.4 bits (93), Expect = 0.004
Identities = 43/211 (20%), Positives = 89/211 (42%), Gaps = 36/211 (17%)
Query: 232 EANAEVMREMTKKLYSQYEEK---------LQEEQRKHSAEKEALLEETNSFLKAIEEAN 282
EA +RE ++L S E+ L + + AE+++ KA+ E+
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 283 KKMQA---------AEISLEEKDQRIGELDRLIERMEKERHQL--QLQLLEHETEMSGEL 331
+ ++ AE++L+E+ + R E+ER Q+ LE + +
Sbjct: 1565 EARRSVDGRLSGVQAELALQEES---------VRRSERERRATLDQVATLERSLQATESE 1615
Query: 332 TDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQL 391
+ +E+ +++ L R L +++ + + ++ + SL+ +LQ+ +L
Sbjct: 1616 LRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL----- 1670
Query: 392 LEKISFLEGENNELQSRLDYLTETQAKTEVE 422
+S E + LQ R+D L A +EV+
Sbjct: 1671 --GLSDREAQAQALQDRVDSLQRQVADSEVK 1699
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 80.1 bits (196), Expect = 5e-15
Identities = 101/461 (21%), Positives = 195/461 (42%), Gaps = 37/461 (8%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
++R Q +KE + + M I +A LEK+ + + +E R K + +
Sbjct: 1210 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRS 1269
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTL---ENSNIKDQI 192
++ +Q+ L+ S LD A+ S L + + L D+ E K+ +
Sbjct: 1270 VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNAL 1329
Query: 193 RNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS--QYE 250
+ Q+ D LRE+ + A+ E Q + K AN+EV + TK Q
Sbjct: 1330 AHALQSARHDCDLLREQYEEETEAKAELQRVLSK------ANSEVAQWRTKYETDAIQRT 1383
Query: 251 EKLQEEQRK---HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE 307
E+L+E ++K E E +E N+ ++E+ ++Q L +R ++
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443
Query: 308 RMEKERHQLQLQLLEHETEMSGELTDSDKERYQ---QLEEASASLRERIRHLDDMVHCQQ 364
+ ++ ++ + + E EL S KE +L + + E + HL+ +
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF----K 1499
Query: 365 KKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
++ K + EEI L ++L I +L + LE E ELQS L+ E +A E E
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALE---EAEASLEHEEG 1556
Query: 425 EIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQ 484
+I L +L F Q + + + E+ +R + +D + + + +
Sbjct: 1557 KI-----LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS-------LDAE 1604
Query: 485 LLSIEESLALQKQQKQNYEEMQAKLA-AQKLAERLNIKMRS 524
S E+L ++K+ + + EM+ +L+ A ++A +++S
Sbjct: 1605 TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645
Score = 74.3 bits (181), Expect = 3e-13
Identities = 87/477 (18%), Positives = 203/477 (42%), Gaps = 52/477 (10%)
Query: 109 ATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALA 168
A L+K ++ E +QK + EL S + L + +A +
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499
Query: 169 SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQV-----ENQLL 223
++ LQ+ + D+T + + I L++ + + E Q LE A+ E ++L
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL 1559
Query: 224 KMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANK 283
+ ++E +Q AE+ R++ +K +E++++ +R H ++L ++ ++ EA +
Sbjct: 1560 RAQLEFNQ-IKAEIERKLAEK-----DEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR 1613
Query: 284 KMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSD--KERYQQ 341
+ E L E + ++ +R+ +K+ LQ L + + ++ + +D KE
Sbjct: 1614 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 342 LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGE 401
+E + L+ + L +V ++ K +E+ +++Q L+ + ++ +
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD 1733
Query: 402 NNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRR 461
++LQ+ ++ + E + ++ ++ ++ D+S+H ++ + E+
Sbjct: 1734 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK---KNMEQTI 1790
Query: 462 RDKQHLDDITAARLLPLHHMPTQLLSIEESL-----ALQKQQKQNYEEMQAK-------- 508
+D QH D A + L QL +E + L+ +QK+N E ++
Sbjct: 1791 KDLQHRLD--EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1848
Query: 509 -------------LAAQKLAERLNIKMRSYNPEGESS--------GRYREVRDEDDD 544
L Q L ++L +K+++Y + E + ++R+V+ E D+
Sbjct: 1849 ELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Score = 66.2 bits (160), Expect = 7e-11
Identities = 78/343 (22%), Positives = 148/343 (43%), Gaps = 33/343 (9%)
Query: 84 QKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQ 143
QK++ +L+EE+ + RA +EK+R + + +E+ +++ + SV
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Query: 144 EYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASM 203
+ E Q L+ + A A+ L+K D E + +QI NLQ+ +
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAA---ALRKKHADSVAE---LGEQIDNLQRVKQKLE 1218
Query: 204 DKLREKQRQL-EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRK--- 259
+ E + +L +V Q++K K AN E M + +++ K +E QR
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAK------ANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272
Query: 260 HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQL--Q 317
++++ L E + ++E + Q++ +L R +E K ++ L
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 318 LQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK----QMVEE 373
LQ H+ ++ +E+Y++ EA A L+ + + V + K + Q EE
Sbjct: 1333 LQSARHDCDLL-------REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1385
Query: 374 IESLKKKLQQKQLLILQLLE----KISFLEGENNELQSRLDYL 412
+E KKKL Q+ + +E K S LE + LQ+ ++ L
Sbjct: 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Score = 64.3 bits (155), Expect = 3e-10
Identities = 85/461 (18%), Positives = 201/461 (43%), Gaps = 48/461 (10%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSA 156
L+ + K VR LE+ ++++ GD ++ I L + ++ L+ ++ +
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND-------KQQLDERLKKKDFE 1086
Query: 157 LDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLR-EKQRQLEV 215
L+ NA + LQK L ++ +++++ ++T A ++KLR + R+LE
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELE-AERTARAKVEKLRSDLSRELE- 1144
Query: 216 AQVENQL--------LKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL 267
++ +L +++++ +EA + MR ++ Q+E ++KH+ L
Sbjct: 1145 -EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 268 LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHET-- 325
E+ ++ + ++ K+ ++ L++ + ++ + +EK L+ Q+ EH +
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 326 -EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQK 384
E + D +R +L+ + L ++ + ++ + +++E LK++L+++
Sbjct: 1264 EETQRSVNDLTSQR-AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 385 QLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSS 444
L + + + L R Y ET+AK E++ ++ + D+
Sbjct: 1323 VKAKNALAHALQSARHDCDLL--REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1380
Query: 445 SHCQKSGSPISSEERRRRDKQHLDDITAARLLPL----HHMPTQ----LLSIEES----L 492
++ +R ++ + + A+ L H + + ++ +E S
Sbjct: 1381 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440
Query: 493 ALQKQQ----------KQNYEEMQAKL-AAQKLAERLNIKM 522
AL K+Q KQ YEE Q++L ++QK A L+ ++
Sbjct: 1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Score = 63.5 bits (153), Expect = 5e-10
Identities = 84/398 (21%), Positives = 172/398 (43%), Gaps = 62/398 (15%)
Query: 184 ENSNIKDQIRNLQQTYEASMDKLRE-KQRQLEVAQVENQL-LKMKVESSQEANAEVMREM 241
E +++K++ L++ E S + +E +++ + + Q +N L L+++ E A+AE +
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
Query: 242 TKKLYSQYEEKLQE------EQRKHSAE---KEALLEETNSFLK--------AIEEANKK 284
K Q E K++E ++ + +AE K+ LE+ S LK + + K+
Sbjct: 908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKE 967
Query: 285 MQAAEISLEEKDQRIGELDRLIERMEKER------HQLQLQLLEHETEMSGELTDSDKER 338
A E ++ + + LD +I ++ KE+ HQ L L+ E + LT + +
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQK------------------------KVKQMVEEI 374
QQ+++ SL + + D+ ++K ++K+ E+
Sbjct: 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGC-DLL 433
+L +++ +Q L QL +K+ L+ EL+ L+ +AK E ++ ++
Sbjct: 1088 NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Query: 434 PRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHL---DDITAARLLPLHHMPTQLLSIEE 490
RL +S + + + ++ RRD + + TAA L H +
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH---------AD 1198
Query: 491 SLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPE 528
S+A +Q N + ++ KL +K +L + + N E
Sbjct: 1199 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Score = 42.7 bits (99), Expect = 9e-04
Identities = 67/301 (22%), Positives = 128/301 (42%), Gaps = 63/301 (20%)
Query: 261 SAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQL-- 318
SAE+E + ++EA +K +A LEEK + L++ EK QLQ+
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEK------MVSLLQ--EKNDLQLQVQA 893
Query: 319 -------------QLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV----- 360
QL++++ ++ ++ + + ER + EE +A L + R L+D
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMN-ERLEDEEEMNAELTAKKRKLEDECSELKR 952
Query: 361 ----------------HCQQKKVKQMVEEI----ESLKKKLQQKQLLILQLLEKISFLEG 400
H + KVK + EE+ E + K ++K+ L + + L+
Sbjct: 953 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 401 ENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEER- 459
E +++ T T+AK ++E + + L R + + + G ++E
Sbjct: 1013 EEDKVN------TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 460 --RRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAER 517
DKQ LD+ + L+ + + IE+ AL Q ++ +E+QA++ ++L E
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNAR---IEDEQALGSQLQKKLKELQARI--EELEEE 1121
Query: 518 L 518
L
Sbjct: 1122 L 1122
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/182 (17%), Positives = 76/182 (41%), Gaps = 7/182 (3%)
Query: 77 RRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ-E 135
R +++ +K + +LK+E +D A LE+++K M +++ ++ + Q
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKE----QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL 195
L Q + LE ++ + L+ N+ ++ + ++T + + + L
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 196 QQTYEASMDKLREKQRQLEVA--QVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKL 253
Q + K++ +RQ E A Q L K + + AE ++ + ++ K
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1924
Query: 254 QE 255
++
Sbjct: 1925 RD 1926
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 80.1 bits (196), Expect = 5e-15
Identities = 106/488 (21%), Positives = 210/488 (43%), Gaps = 69/488 (14%)
Query: 107 VRATLEKV------RKRMYGDYDEMRQKIRQLTQE--LSVSHAQQEY--------LENHI 150
+R TLE++ +K+ DE +K+ ++ Q LS ++++ E H+
Sbjct: 284 LRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHV 343
Query: 151 QTQSSALDRFNAMNSAL----------ASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYE 200
S L++ NS L A DS + + +++S I R L+ E
Sbjct: 344 HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEE 403
Query: 201 A----------SMDKLREKQRQLEVAQVENQLLKMKVE------SSQEANAEVMREMTKK 244
S ++ E+ +Q+EV + ++ +K KVE SS+EA E +++
Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAG 463
Query: 245 LYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
L ++ + QE RK + E AL + + ++ + ++ + SL K+QR L
Sbjct: 464 LQAEIGQVKQELSRKDT-ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL-- 520
Query: 305 LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQ 364
+ E L+L+L E ET + + ++ Q + E + I L DM+ ++
Sbjct: 521 -----QTEVDALRLRLEEKET-----MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE 570
Query: 365 KKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
+KV + ++IE+L+++L+ K+ + L E++ L+ + + L L E A+ E
Sbjct: 571 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE 630
Query: 425 EIGVGCDLLPRLPFRQNDSSSHCQKS--------GSPISSEERRRRD-KQHLDDITAARL 475
+ D R + D+ K +S +E D K+H + ++ L
Sbjct: 631 RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGL 690
Query: 476 LPLHHMPTQLLSI----EESLALQKQQKQNYEEMQAKLAAQKLAERL-NIKMRSYNPEGE 530
+ T +++ EE L ++ Q K+ +E A+ ++++R+ +++ + E
Sbjct: 691 KKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 750
Query: 531 SSGRYREV 538
SS EV
Sbjct: 751 SSKAQAEV 758
Score = 67.0 bits (162), Expect = 4e-11
Identities = 112/531 (21%), Positives = 217/531 (40%), Gaps = 84/531 (15%)
Query: 47 KKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKD 106
+ +E + Q+L + T + + + V RS K V QLKEE++ +
Sbjct: 399 RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV------EQLKEELSSKEA 452
Query: 107 VRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN-------HIQTQSSALDR 159
L+K + + +++Q++ + EL + E L N HI+ +L
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 160 FNAMNSALASDSIGLQKTLVD-VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQV 218
+ L ++ L+ L + T+ N K QI+++ + ++ + + L+V +
Sbjct: 513 KEQRAAILQTEVDALRLRLEEKETMLNKKTK-QIQDMAEEKGTQAGEIHDLKDMLDVKER 571
Query: 219 ENQLLKMKVESSQEANAEVMREM----------------TKKLYSQYEEKLQEEQR---- 258
+ +L+ K+E+ QE + ++M T + EE L E++R
Sbjct: 572 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 631
Query: 259 ---KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR-----LIERME 310
+ ++ EE +++ K +++ +K+ + L EK+ + +L ++
Sbjct: 632 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 691
Query: 311 KERHQLQLQL-LEHETEMSGELTDSDKERYQQLEEASAS--LRERIRHLDDMVHCQQKKV 367
K+ L++ LE + E ++ K+ ++ EA AS + +RI+HL+
Sbjct: 692 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE---------- 741
Query: 368 KQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYL-----------TETQ 416
EI K + + Q + +LLE + +E E N+ ++ L +
Sbjct: 742 ----REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK 797
Query: 417 AKTEVETREIGVGCDLLPRLPFRQNDSSSHCQ----KSGSPISSEERRRRDKQHLDDITA 472
K +VE ++ + R NDSS Q K I E R+ ITA
Sbjct: 798 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV---QITA 854
Query: 473 ARLLPLHHMPTQLLS----IEESLALQKQQKQNYEEMQAKLAA--QKLAER 517
R + L + + +EE L ++ KQ E M+AKL++ Q LAE+
Sbjct: 855 EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 905
Score = 59.3 bits (142), Expect = 9e-09
Identities = 78/362 (21%), Positives = 166/362 (45%), Gaps = 47/362 (12%)
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALAS 169
T+E+++++ D E +++I ++L + L+ + + ++L S+LAS
Sbjct: 628 TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 687
Query: 170 DSIGLQKTLVDVTLENSNIKDQI----RNLQQTYEASMDKLREKQRQLEVAQVENQLLKM 225
+ L + + K++ L++ +EA+++ + + +E ++ +
Sbjct: 688 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
Query: 226 KVESSQEANAEVMR--EMTKKLYSQYEEKLQ-----EEQRKHSAEKEALLE-----ETNS 273
K ESS+ A AEV R E+ K++ ++ +K + E Q K +K A L+ E
Sbjct: 748 KDESSK-AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK 806
Query: 274 FLKAIEEA-------NKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETE 326
+ +EEA N Q + SL +KD RI EL+ + + + ++ L + E+
Sbjct: 807 SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 866
Query: 327 MSG------ELTDSDKERYQQLEEASA-------SLRERIRHLDDMVHCQQKKVKQMVE- 372
+ EL + ++ Q+LE A SL E+ HL ++ ++K +++++E
Sbjct: 867 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 926
Query: 373 EIESLKKKLQQK--QLLILQL-------LEKISFLEGENNELQSRLDYLTETQAKTEVET 423
+ E+L + +K + +L+L E+++ L+ E + L +L T+ + K +
Sbjct: 927 KQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN 986
Query: 424 RE 425
E
Sbjct: 987 YE 988
Score = 56.6 bits (135), Expect = 6e-08
Identities = 104/495 (21%), Positives = 192/495 (38%), Gaps = 119/495 (24%)
Query: 147 ENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKL 206
E+H+ S A +++ A + + LQ L +V EN ++ + + +SM+ +
Sbjct: 127 EHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI 186
Query: 207 R-------EKQR---------------QLEVAQVENQLLKMKVESSQE------------ 232
+ +K+R Q V Q ENQ ++M +++ Q+
Sbjct: 187 KTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLF 246
Query: 233 -----------ANAEVMREMTKKLYSQYEEKLQE--EQRKHSAEKEALLEETNSFLKAIE 279
AE+ E ++L++++E + +E RK E E +E L A +
Sbjct: 247 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 280 EANKK----MQAAEIS-------------LEEKDQRIGELDRLIERMEKERHQLQLQL-- 320
E+ KK +Q+ +S L E + + L+ L+E+ EKE L+ ++
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR 366
Query: 321 -------------LEHETEMSGELTDSDKERYQQLEE--------ASASLRERIRHLDDM 359
L+ EM S + + LEE + S ER + M
Sbjct: 367 RFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
Query: 360 VHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGE----NNELQSRLDYLTET 415
+ K M ++E LK++L K+ +L +K + L+ E EL + L
Sbjct: 427 -EVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLAL 485
Query: 416 QAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARL 475
Q K E T + +DS H + ++++E+R Q ++ A RL
Sbjct: 486 QTKLETLTNQF--------------SDSKQHIEVLKESLTAKEQRAAILQ--TEVDALRL 529
Query: 476 LPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQ--KLAERLNIKMRSYNP-EGESS 532
+L E L + +Q Q+ E + A + L + L++K R N + +
Sbjct: 530 --------RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581
Query: 533 GRYREVRDEDDDWSS 547
++RD++ SS
Sbjct: 582 NLQEQLRDKEKQMSS 596
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 80.1 bits (196), Expect = 5e-15
Identities = 84/421 (19%), Positives = 185/421 (43%), Gaps = 75/421 (17%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEM----------------NYIKDVRATLEKVRKRMY 119
V ++ ++E+ V T ++K+E+ + IK+ ++++ K +
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 120 GDYDEMRQKIRQLTQELSVSHAQQEYLE-------NHIQTQSSALDRFNAMNSALASDSI 172
+++ +++ + L A E LE +Q S+ LD F + SA +
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 173 GLQKTLVDVTLENSNIK-DQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQ 231
++ L + + +++ ++I +Q E K ++ +L+ +++ Q L ++E
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDAHKIQVQDLMQQLEKQ- 873
Query: 232 EANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFL-------KAIEEANKK 284
N+E M + K L YE KL++ ++ K+ L+E+ N L K IE +K
Sbjct: 874 --NSE-MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930
Query: 285 MQAAEISL----EEKDQRIGELDRLIERMEKERHQLQ----LQLLEHETEMSGELTDSDK 336
+ A E S+ EE + + ++ +E+++++ ++Q +LL+ E ++ EL ++
Sbjct: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL 990
Query: 337 ERYQQLEEASASLRERI------------------------------RHLDDMVHCQQKK 366
E Q+ ++ +A + E R L+D++ +KK
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 367 VKQMVEEIESLKK-KLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ Q EE++ + + +LQ+K+ + +L +KI E E+ + +L E K + E
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 426 I 426
+
Sbjct: 1111 L 1111
Score = 77.0 bits (188), Expect = 4e-14
Identities = 93/419 (22%), Positives = 189/419 (45%), Gaps = 62/419 (14%)
Query: 50 ERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRA 109
E ++ L E R+ + + ++ ++ ++E + S++K+E+ + ++
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK-KS 473
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQEL-------------SVSHAQQEYL---ENHIQTQ 153
+ E++ K E+ +K ++LT++L ++ +Q EYL + Q +
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 154 SSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
S AL+ A+ ++S + L D+ E + +I L+ + E S+ + + + + L
Sbjct: 534 SLALEELELQKKAILTES---ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
Query: 214 EV--------------AQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRK 259
V VE K ++ES + + E + L QY+ ++++ + K
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKH--KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 260 HSAEKEALLEETNSFLKA-IEEANKKMQAAEISLEEKDQRIGELDRL---IERMEKERHQ 315
EKE LL++ +A IEE N+K +LE+ D + EL+ L + + K RH+
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEK------TLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 316 L--QLQLLEHETE-MSGEL---TDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
L +L +L+ +T+ M EL D K +QQ ++ I+ + + +K +K
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI------IKEHEVSIQRTEKALKD 756
Query: 370 MVEEIESLKKK----LQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
+ ++E L K+ L++ Q + L I EGE + ++LD Q+ T +T+
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Score = 67.4 bits (163), Expect = 3e-11
Identities = 102/439 (23%), Positives = 192/439 (43%), Gaps = 58/439 (13%)
Query: 124 EMRQKIRQLTQE---LSVSHAQQ----EYLENHIQTQSSALDRFNAMNSALASDSIGLQK 176
E+ ++RQLT+E L++S Q E EN I++ + ++ AL + Q+
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 177 TLVDVTLENSNIKDQIRNLQQTYEA-SMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
+ + S I + L + A ++ K K++++E++ + QL + V+ +
Sbjct: 1333 AASE---KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 236 EVMREMTKKLYSQYEE---KLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM----QAA 288
L QY+E +L ++ + S + + L +E S L+ +++ + K + A
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 289 EISLEEKDQRIGELDRLIERMEKERHQL--QLQLLEHETE--------MSGELTDSDKER 338
+ + + EL +E KE ++ Q+ LL+ E + + GE+ D DK +
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED-DKSK 1508
Query: 339 YQQ----LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL----QQKQLLILQ 390
++ LE S RI L+D H QK + EIESL + L QQK + +
Sbjct: 1509 MEKKESNLETELKSQTARIMELED--HITQKTI-----EIESLNEVLKNYNQQKDIEHKE 1561
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKS 450
L++K+ + E +R+ +A+ ++ T E V + L ++ + H S
Sbjct: 1562 LVQKLQHFQELGEEKDNRV-----KEAEEKILTLENQV-YSMKAELETKKKE-LEHVNLS 1614
Query: 451 GSPISSEERRRRDKQHLDDITAARLLPLHHMPTQ-LLSIEESLALQKQQKQNYEEMQAKL 509
S EE + + L+ +AA+L L Q + +I++ L Q ++K E Q K
Sbjct: 1615 VK--SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK----EEQYKK 1668
Query: 510 AAQKLAERLNIKMRSYNPE 528
+ LN K++ E
Sbjct: 1669 GTESHLSELNTKLQERERE 1687
Score = 60.5 bits (145), Expect = 4e-09
Identities = 117/563 (20%), Positives = 231/563 (41%), Gaps = 83/563 (14%)
Query: 20 GAPSRRAN-----VCRLRLTVPP-----ESPVPEQCEKKIERKEQLLDLSNGEPTRKLP- 68
G P+R + +L+L VP SP+ E + KE L+ S+ E +L
Sbjct: 49 GTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRS-SSKESLVRTSSRESLNRLDL 107
Query: 69 QGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQK 128
SD + + E +V G S S KE++ ++++R RM R K
Sbjct: 108 DSSTASFDPPSDMDSEAEDLV-GNSDSLNKEQL---------IQRLR-RMERSLSSYRGK 156
Query: 129 IRQLTQELSVSHAQQEYLENHI-QTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSN 187
+L + +++ L+ + Q+Q +L R + L D
Sbjct: 157 YSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMD----------------- 199
Query: 188 IKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS 247
+ ++LQ+ ++AS++ EK + + V Q + LLK ++ + N +V++ + + L
Sbjct: 200 -QQAKKHLQEEFDASLE---EKDQYISVLQTQVSLLKQRLRNGP-MNVDVLKPLPQ-LEP 253
Query: 248 QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE 307
Q E +EE + E + E + +K +E ++++ E L+ + I
Sbjct: 254 QAEVFTKEENPESDGEP---VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT 310
Query: 308 RMEKERHQLQLQLLEH--------------ETEMSGELTDSDKERYQQLE--------EA 345
+ E+ LQ QL E +T++ +L D+ K +QLE E
Sbjct: 311 LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDA-KNLIEQLEQDKGMVIAET 369
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNEL 405
+ E + ++ + + ++KQM + E L+++ ++ + + LEK + E
Sbjct: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 406 QSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQ 465
+ +L + Q KT +T E L L + + +KS S E+ + K
Sbjct: 430 RRKLKAEMDEQIKTIEKTSE-EERISLQQELSRVKQEVVDVMKKS----SEEQIAKLQKL 484
Query: 466 HLDDITAARLLPLHHMPTQLLSIEESL--ALQKQQKQNYEEMQAKLAAQKLA-ERLNIKM 522
H ++ + T+ +E + AL+K Q + + Q K + LA E L ++
Sbjct: 485 HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544
Query: 523 RSYNPEGESSGRYREVRDEDDDW 545
++ E E+ + R+++ E + +
Sbjct: 545 KAILTESEN--KLRDLQQEAETY 565
Score = 59.3 bits (142), Expect = 9e-09
Identities = 87/500 (17%), Positives = 214/500 (42%), Gaps = 50/500 (10%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEK-VRKRMYGDYDEMRQKIRQLTQ 134
+R+ + Q + + +T QL+E+ N IK ++A +E V ++ + Q+ +
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
E ++ ++E EN + L + + S+ Q T ++V L+NS +
Sbjct: 1338 ESCITQLKKELSEN---INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE--- 1391
Query: 195 LQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
++ +S+ K ++++ + QV++ K+ S ++ +A + +S++++K Q
Sbjct: 1392 -KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI----GELDRLIERME 310
+H + L + K E ++++ + L+++++R GE++ +ME
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510
Query: 311 KERHQLQ----------LQLLEHETEMSGELTDSDK-----------------ERYQQLE 343
K+ L+ ++L +H T+ + E+ ++ ++ Q +
Sbjct: 1511 KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ 1570
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGE-N 402
E R++ ++ + + +V M E+E+ KK+L+ L + E++ LE
Sbjct: 1571 ELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE 1630
Query: 403 NELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRR 462
+E ++L + K + E + + LL ++ ++ + S ++++ + R
Sbjct: 1631 SESAAKL-----AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685
Query: 463 DKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQK-LAERLNIK 521
+ H I +L + ++ L + S A EE ++ QK E++++
Sbjct: 1686 REVH---ILEEKLKSVESSQSETLIVPRS-AKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
Query: 522 MRSYNPEGESSGRYREVRDE 541
R+ + + R + ++E
Sbjct: 1742 QRNLTEKEKLLQRVGQEKEE 1761
Score = 54.7 bits (130), Expect = 2e-07
Identities = 72/338 (21%), Positives = 152/338 (44%), Gaps = 35/338 (10%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTL--VD 180
+EM ++I L +E +Q+ N +Q Q L + +A ++LA D L+ L ++
Sbjct: 1088 EEMNKEITWLKEE----GVKQDTTLNELQEQ---LKQKSAHVNSLAQDETKLKAHLEKLE 1140
Query: 181 VTL-----ENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
V L EN+ +++Q+ L+ E K+ E +L+ E Q LK E S ++
Sbjct: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE 1200
Query: 236 EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE--------TNSFLKAIEEANKKMQA 287
+ E KKL + +L +K A EA E TN+ L I +
Sbjct: 1201 DKSLEF-KKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 288 AEISLEEKDQRIGELDRLIERMEKERHQLQL-------QLLEHETEMSGELTDSDK--ER 338
+ +L K + EL+ + ++ +E++ L + QL E E ++ D +
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFL 398
+ L++ + ++ + + +K++ + + + +K++L++K++ I L ++++ L
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Query: 399 EGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRL 436
N +LQ+ + + A + + + C+LL ++
Sbjct: 1380 ---NVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
Score = 46.2 bits (108), Expect = 8e-05
Identities = 88/468 (18%), Positives = 184/468 (39%), Gaps = 81/468 (17%)
Query: 75 VVRRSDQN-----QQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRM-------YGDY 122
+V RS +N +Q+E G +E+++ ++ EK+ +R+ +
Sbjct: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQ--KTLVD 180
EMR + ++ +L + A+Q ++ I L+ N S + + + + K +
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ 1826
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
N+ D ++ Q E + L +K ++L+ V + EV R
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQK--------------EVHRV 1872
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
++L S+YE KLQ L+ ++ NK + E + EEK +
Sbjct: 1873 EMEELTSKYE-KLQA-------------------LQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 301 ELDRLIERMEKERHQLQLQLLEHETE----------MSGELTDSDKERYQQLE----EAS 346
+L+ ME + + L+ +L E E + +L KE Q+LE E
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 347 ASLRERIR-HLDDMVHCQQKKVKQMVEEIES-LKKKLQQKQLLILQLLEKISFLEG---- 400
E+I+ +D+ +KQ++ E + L +K Q+ ++ I + + K +E
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE 2032
Query: 401 ----ENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISS 456
E N+L ++ + +T EI L R+ + ++ + + +
Sbjct: 2033 SHQEETNQLLKKIAEKDDDLKRTAKRYEEI---------LDAREEEMTAKVRDLQTQLEE 2083
Query: 457 EERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEE 504
+++ + K ++ + + + TQL ++ K ++Q + E
Sbjct: 2084 LQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 79.0 bits (193), Expect = 1e-14
Identities = 67/301 (22%), Positives = 152/301 (50%), Gaps = 22/301 (7%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAM----NSALASDSIGLQKTL 178
+E+++K +L ++L + +++ ++ +++ L+R + + +D +G +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 179 VDVTLENSNIKDQIRNL-QQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEV 237
V L+ ++++ NL Q E M + EK ++ E E +L K+ +E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL---KIREQEEK---- 326
Query: 238 MREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
M +K++ Q EEK++E++ K ++E + E+ I E +KM E + E+D+
Sbjct: 327 MWRQEEKMHEQ-EEKIREQEDKMWRQEEKIREQEEK----IREQEEKMWRQEEKIREQDE 381
Query: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD 357
+I E + + R E++ + + + E ++ + D E+ ++ EE E+IR L+
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD-EKIREQEEEMWRQEEKIRELE 440
Query: 358 DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQA 417
+M+ Q++K++++ E+++ ++K+Q+++ I + EKI E E R + L + +
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ----EQEEKTWRQEKLLKQEE 496
Query: 418 K 418
K
Sbjct: 497 K 497
Score = 55.5 bits (132), Expect = 1e-07
Identities = 50/283 (17%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 82 NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHA 141
NQQ+E ++ +++E+ + + + + ++M+ ++M ++ ++ ++
Sbjct: 292 NQQQEEKMWR-QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWR 350
Query: 142 QQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA 201
Q+E + + ++ + +Q+ ++ + I++Q Q+
Sbjct: 351 QEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWR 410
Query: 202 SMDKLREKQRQLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEEQR 258
K+RE+ ++ + E + K+ +E E +RE+ +K+ + EEK+QE++
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE-EEKMQEQEE 469
Query: 259 K---------HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERM 309
K EK E+ + I E +KM E + E+++++ E + ++R
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 310 EKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER 352
E++ + +++L + E +M + R Q+LEE L ++
Sbjct: 530 EEKMREQEVRLWQQEEKM-----QEQEVRLQELEERLGKLGQK 567
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 79.0 bits (193), Expect = 1e-14
Identities = 67/301 (22%), Positives = 152/301 (50%), Gaps = 22/301 (7%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAM----NSALASDSIGLQKTL 178
+E+++K +L ++L + +++ ++ +++ L+R + + +D +G +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 179 VDVTLENSNIKDQIRNL-QQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEV 237
V L+ ++++ NL Q E M + EK ++ E E +L K+ +E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL---KIREQEEK---- 326
Query: 238 MREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
M +K++ Q EEK++E++ K ++E + E+ I E +KM E + E+D+
Sbjct: 327 MWRQEEKMHEQ-EEKIREQEDKMWRQEEKIREQEEK----IREQEEKMWRQEEKIREQDE 381
Query: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD 357
+I E + + R E++ + + + E ++ + D E+ ++ EE E+IR L+
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD-EKIREQEEEMWRQEEKIRELE 440
Query: 358 DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQA 417
+M+ Q++K++++ E+++ ++K+Q+++ I + EKI E E R + L + +
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ----EQEEKTWRQEKLLKQEE 496
Query: 418 K 418
K
Sbjct: 497 K 497
Score = 55.5 bits (132), Expect = 1e-07
Identities = 50/283 (17%), Positives = 126/283 (44%), Gaps = 19/283 (6%)
Query: 82 NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHA 141
NQQ+E ++ +++E+ + + + + ++M+ ++M ++ ++ ++
Sbjct: 292 NQQQEEKMWR-QEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWR 350
Query: 142 QQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA 201
Q+E + + ++ + +Q+ ++ + I++Q Q+
Sbjct: 351 QEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWR 410
Query: 202 SMDKLREKQRQLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEEQR 258
K+RE+ ++ + E + K+ +E E +RE+ +K+ + EEK+QE++
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE-EEKMQEQEE 469
Query: 259 K---------HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERM 309
K EK E+ + I E +KM E + E+++++ E + ++R
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 310 EKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER 352
E++ + +++L + E +M + R Q+LEE L ++
Sbjct: 530 EEKMREQEVRLWQQEEKM-----QEQEVRLQELEERLGKLGQK 567
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 78.6 bits (192), Expect = 1e-14
Identities = 130/547 (23%), Positives = 226/547 (41%), Gaps = 70/547 (12%)
Query: 12 SGGAA--RTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQ 69
+GGA+ + G R A + RLR + + E + RK+ GE L
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-- 1259
Query: 70 GVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKI 129
+R Q +KE L + + +A+ EK+ + E + K+
Sbjct: 1260 -------QRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKV 1312
Query: 130 RQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTL------ 183
+L ++L+ + Q+ +QT+S L R L S + K L +L
Sbjct: 1313 EELQRQLADASTQR----GRLQTESGELSRLLEEKECLIS-QLSRGKALAAQSLEELRRQ 1367
Query: 184 --ENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREM 241
E S K + + Q D LRE+ + AQ E Q L K ANAEV +
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK------ANAEVAQWR 1421
Query: 242 TKKLYS--QYEEKLQEEQRK---HSAEKEALLEETNSFLKAIEEANKKMQ--AAEISLEE 294
+K Q E+L+E ++K E E +E N+ ++E+A ++Q + +++LE
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 295 K---------DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERY------ 339
+ D++ L+R +E ++ ++Q +L + E G T+ + R+
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 340 ---QQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI- 395
+ L+ + +L+E I L D V K ++E+E KK L+ ++ I LE+
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKS----IQELEKTKKALEGEKSEIQAALEEAE 1597
Query: 396 SFLE-GENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPI 454
LE E L+ +L+ L++ +A+ + + E C L R R +S + +
Sbjct: 1598 GALELEETKTLRIQLE-LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRA 1656
Query: 455 SSEERRRRDKQH--LDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQ 512
+E R + K L+D+ L L H Q + E A + Q Q EE + Q
Sbjct: 1657 RNEALRLKKKMEGDLNDLE----LQLGHATRQ--ATEAQAATRLMQAQLKEEQAGRDEEQ 1710
Query: 513 KLAERLN 519
+LA L+
Sbjct: 1711 RLAAELH 1717
Score = 72.0 bits (175), Expect = 1e-12
Identities = 101/442 (22%), Positives = 184/442 (41%), Gaps = 68/442 (15%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIR----QLTQELSVSHAQQEYLENHIQT 152
L+E+ + +A L+++ + + + R K Q T+EL + ++ L +Q
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA---KKKLALRLQE 1448
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDVTLENSN-------IKDQIRNLQQTYEASMDK 205
++ NA S+L + LQ DVTLE + + R+L++ E +
Sbjct: 1449 AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQ 1508
Query: 206 LREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKE 265
E QR+LE AQ E++ L ++ + + E + + E L+ E + E
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL---------ETLKRENKNLQEEIS 1559
Query: 266 ALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHET 325
L ++ + K+I+E K +A E E + E + +E E + ++QL+L + +
Sbjct: 1560 DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 326 EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQ 385
E+ +L + D+E A+LR + + + + E LKKK
Sbjct: 1620 EVDRKLAEKDEE--------CANLRRNHQRAVESLQASLDAETRARNEALRLKKK----- 1666
Query: 386 LLILQLLEKISFLEGENNELQSRLDY----LTETQAKT---EVETREIGVGCDLLPRLPF 438
+EG+ N+L+ +L + TE QA T + + +E G D RL
Sbjct: 1667 ------------MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAA 1714
Query: 439 RQNDSSSHCQKSGSPISSE-----------ERRRR-DKQHLDDITAARLLPLHHMPTQLL 486
++ + ++ S +++E ER RR +Q L + T RL LH T LL
Sbjct: 1715 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEAT-ERLNLLHSQNTGLL 1773
Query: 487 SIEESLALQKQQKQNYEEMQAK 508
+ ++ L Q E A+
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQ 1795
Score = 62.0 bits (149), Expect = 1e-09
Identities = 66/291 (22%), Positives = 126/291 (43%), Gaps = 49/291 (16%)
Query: 184 ENSNIKDQIRNLQQTYEASMDKLRE-KQRQLEVAQVENQL-LKMKVESSQEANAEVMREM 241
E + ++ ++R L+ A+ K +E ++ + + Q +N L L+++ E A+AE +
Sbjct: 897 ELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHL 956
Query: 242 TKKLYSQYE-------EKLQEEQRKHS---AEKEALLEETNSFLKAIEE-------ANKK 284
K Q E E+L++E+ ++ A + L +E K I++ A K+
Sbjct: 957 LIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE 1016
Query: 285 MQAAEISLEEKDQRIGELDRLIERMEKER------HQLQLQLLEHETEMSGELTDSDKER 338
QA E ++ + + LD + R+ KE+ HQ L L+ E + LT +
Sbjct: 1017 KQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRL 1076
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQK------------------------KVKQMVEEI 374
QQ+E+ SL + + D ++K K+K+ E+
Sbjct: 1077 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
L +++ +QLL Q+ +KI L+ EL+ L+ +A+ E + E
Sbjct: 1137 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Score = 58.9 bits (141), Expect = 1e-08
Identities = 98/488 (20%), Positives = 197/488 (40%), Gaps = 71/488 (14%)
Query: 85 KEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQE 144
K V +L E + ++V A L R+++ + E+++ I L L+ + +++
Sbjct: 959 KSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ 1018
Query: 145 YLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMD 204
EN ++ L + L +++ +T E + LQ+ ++ ++
Sbjct: 1019 ATENKVKN--------------LTEEMAALDESVARLTKEK-------KALQEAHQQALG 1057
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
L+ ++ ++ L+ +VE + E E KKL ++ E+ K E
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVE-----DLECSLEQEKKL------RMDTERAKRKLEG 1106
Query: 265 EALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE-------RMEKERHQLQ 317
+ L + +++ +A + Q E L++KD + +L +E +M+K+ +LQ
Sbjct: 1107 DLKLTQ-----ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 318 LQLLEHETEMSGELTDSDKERYQQLEEAS--ASLRERIRHLDDMVHCQQKKVKQMVEEIE 375
+ E E E+ E + Q+ E A L ER+ Q++ ++ E+
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 376 SLKKKLQQKQLLILQLLEKISFLEGEN-NELQSRLDYLTETQAKTEVETREIGVGCDLL- 433
L+++L++ L + + + E EL ++D L + K E E E+ + D L
Sbjct: 1222 RLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLA 1281
Query: 434 ---PRLPFRQNDSSSHC-----QKSGSPISSEERRR--------RDKQHLDDITAARLLP 477
L + + C Q S + I EE +R R + + +RLL
Sbjct: 1282 ANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLE 1341
Query: 478 LHHMPTQLLSIEESLA---LQKQQKQNYEEMQAKL----AAQKLAERLNIKMRSYNPEGE 530
LS ++LA L++ ++Q EE +AK A Q L ++ + E E
Sbjct: 1342 EKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE 1401
Query: 531 SSGRYREV 538
+ + +
Sbjct: 1402 AQAELQRL 1409
Score = 57.8 bits (138), Expect = 3e-08
Identities = 97/457 (21%), Positives = 192/457 (42%), Gaps = 74/457 (16%)
Query: 84 QKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQ 143
QK++ +L+EE+ + RA +EK R + +E+ +++ + S Q+
Sbjct: 1154 QKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG---GASAGQR 1210
Query: 144 EYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASM 203
E + + + L R L++ L + L + +R Q A +
Sbjct: 1211 E----GCRKREAELGR--------------LRRELEEAALRHEATVAALRRKQAEGAAEL 1252
Query: 204 -DKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM---REMTKKLYSQYEEKLQEEQRK 259
+++ QR + + E L+M+V+ AN E + + +KL YE++L E + K
Sbjct: 1253 GEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 260 HSAEKEALLEETNSFLKAIEEANKKMQAAEIS--LEEKDQRIGELDR----LIERMEKER 313
+ L + + + + ++ E+S LEEK+ I +L R + +E+ R
Sbjct: 1312 VEELQRQLADAST------QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 314 HQLQLQ-----LLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK 368
QL+ + L H + D +E++++ EA A L+ + + V + K +
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 369 ----QMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
Q EE+E KKK L L+L E +E N + S L + + + + E+
Sbjct: 1426 ADAIQRTEELEEAKKK------LALRLQEAEEGVEAANAKCSS----LEKAKLRLQTESE 1475
Query: 425 EIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAAR---------L 475
++ + + + H ++ + EERRR++++ ++ AA+ L
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLER-----ALEERRRQEEEMQRELEAAQRESRGLGTEL 1530
Query: 476 LPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQ 512
L H + L E+L K++ +N +E + L Q
Sbjct: 1531 FRLRHGHEEAL---EALETLKRENKNLQEEISDLTDQ 1564
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/322 (18%), Positives = 141/322 (43%), Gaps = 36/322 (11%)
Query: 113 KVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSI 172
+++K+M GD +++ ++ T++ + + A ++ ++ + + D + + L +
Sbjct: 1662 RLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQ 1721
Query: 173 GLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE 232
L++ + E ++ + +++ + +L E +L + +N L + ++
Sbjct: 1722 ALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGL---LNQKKK 1778
Query: 233 ANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISL 292
A++ + L + EE QE + K+A+ + M A E+
Sbjct: 1779 LEADLAQ-----LSGEVEEAAQERREAEEKAKKAITDAA-------------MMAEELKK 1820
Query: 293 EEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLE----EASAS 348
E+ L+R+ + +E+ +LQ +L E E K++ Q+LE E A
Sbjct: 1821 EQDTS--AHLERMKKTLEQTVRELQARLEEAEQ----AALRGGKKQVQKLEAKVRELEAE 1874
Query: 349 L-RERIRHLDDM--VHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFL--EGENN 403
L E+ +H + + V +++VK++ + E +K L + Q L+ +L K+ + E
Sbjct: 1875 LDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEA 1934
Query: 404 ELQSRLDYLTETQAKTEVETRE 425
E Q+ + +A+ E++ E
Sbjct: 1935 EQQANTNLAKYRKAQHELDDAE 1956
Score = 33.5 bits (75), Expect = 0.52
Identities = 30/170 (17%), Positives = 71/170 (41%), Gaps = 6/170 (3%)
Query: 77 RRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ-E 135
RR + + K+ + + + EE+ +D A LE+++K + E++ ++ + Q
Sbjct: 1797 RREAEEKAKKAIT---DAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL 195
L Q + LE ++ + LD ++ ++ + ++ + + + +
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARM 1913
Query: 196 QQTYEASMDKLREKQRQLEVA--QVENQLLKMKVESSQEANAEVMREMTK 243
Q + K++ +RQ E A Q L K + + +AE +M +
Sbjct: 1914 QDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAE 1963
>gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens]
Length = 602
Score = 78.2 bits (191), Expect = 2e-14
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 14/367 (3%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
VRRS Q+ ++ G +++++ ++ T E + + D + ++Q E
Sbjct: 137 VRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESE 196
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE-NSNIKDQIR- 193
+S + L+N I S D + + A D L+ T+ + E +I D I
Sbjct: 197 VSRISEVLQKLQNEILKDLS--DGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAI 254
Query: 194 --NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM-REMTKKLYSQYE 250
+Q+ + ++ ++ K LE ++ Q LK E+ +E RE +
Sbjct: 255 FTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
+ ++ + E +L +E +F +A + +QA L ++ + L I R+E
Sbjct: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLE 374
Query: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
+E QL+ H + G S E ++ L++ S L R++H++D V Q +
Sbjct: 375 EELRQLKSD--SHGPKEDGGFRHS--EAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
Query: 371 VEEIESLKKKLQQKQLLILQL---LEKISFLEGENNELQSRLDYLTETQAKTEVETREIG 427
E +ESL K Q+ + + L LE + E + + L S + L ETQ + E+
Sbjct: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK 490
Query: 428 VGCDLLP 434
LP
Sbjct: 491 RSVGELP 497
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/344 (17%), Positives = 143/344 (41%), Gaps = 29/344 (8%)
Query: 75 VVRRSDQ--NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL 132
V +RS + N K V + K+++ +K+ ++ K D + +R ++ +
Sbjct: 258 VQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTM 317
Query: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
++ + L+ Q A D AL + ++++ + E +++++
Sbjct: 318 ESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
Query: 193 RNLQQT-----------YEASMDKLREKQRQLE--VAQVENQLLKMKVESSQEANAEVMR 239
R L+ + + + L++K + L+ + VE+ +L M+V S+++ E +
Sbjct: 378 RQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT--ESLE 435
Query: 240 EMTKKLYSQYEEKLQEEQRKHSA--EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
+ K ++E++L Q + EA + S ++++ E + +EE +
Sbjct: 436 SLLSKS-QEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG---DVEELKR 491
Query: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE------ 351
+GEL +E ++K + Q+ L + + + + +R L+ AS+ +
Sbjct: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLK 551
Query: 352 RIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI 395
+R D + K++ +ES K L + + +L K+
Sbjct: 552 MLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKV 595
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 77.8 bits (190), Expect = 2e-14
Identities = 96/443 (21%), Positives = 201/443 (45%), Gaps = 38/443 (8%)
Query: 104 IKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAM 163
++D++ E+++K++ E R + T +L E L + Q L R
Sbjct: 682 LRDIQEEKEEIQKKL----SESRHQQEAATTQL-------EQLHQEAKRQEEVLARAVQE 730
Query: 164 NSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLL 223
AL + L+ L V + ++ +Q++ L E L E Q+Q V +V L
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
Query: 224 KMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALL--EETNSFLKAIEEA 281
++++++ +A + E+ E+ Q EQ + +A ++ +E + L+ + A
Sbjct: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
Query: 282 NKK--MQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERY 339
++K Q E +E+ EL + +E +E+E+ +L+++L E +TEM ++ER
Sbjct: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEER- 909
Query: 340 QQLEEASASL-----RERIRHLDDMVHCQQKKVKQMVEEIESLK-----KKLQQKQ---L 386
Q E A + +ER+ L+ ++ QK++ +++E L+ +KL++++ +
Sbjct: 910 TQAESALCQMQLETEKERVSLLETLLQ-TQKELADASQQLERLRQDMKVQKLKEQETTGI 968
Query: 387 LILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSH 446
L QL E L+ + + L L E + + ++ + L Q+DS
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Query: 447 C-QKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQ----KQN 501
Q+ + + R ++ L+ A+ L L +LL ++E+ ++++Q+ +Q+
Sbjct: 1029 VEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
Query: 502 YEEMQA---KLAAQKLAERLNIK 521
+E Q +L+AQ R +K
Sbjct: 1089 MQEAQGEQKELSAQMELLRQEVK 1111
Score = 73.2 bits (178), Expect = 6e-13
Identities = 110/497 (22%), Positives = 216/497 (43%), Gaps = 100/497 (20%)
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQELS---VSHAQQEYLENHIQTQ----SSALDRFNA 162
TL + + + + + +RQ+ ++T L+ S A+ EN ++T+ +A + +A
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 163 MNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQL 222
+N ALA D +GL + L+ + EN ++ ++ +Q A L E +++ E +N
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 223 LKMKVESSQEANAEVM----------REMTKKL----------YSQYEEKLQEEQRKHSA 262
L+ +++ ++EA AE+ E+ KKL +Q E+ QE +R+
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 263 ------EKEALLEETNSF---LKAIEEANKKM-----------QAAEISLEEKDQR---- 298
EKEAL+ E + L+A+E + + + E SL E Q+
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 299 ---IGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRH 355
G+L+ I+ + + + +Q ++ + E+ E + +++ER + + + +E
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 356 LDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF-LEGENNELQSRLD---- 410
L+ +K+V Q+ E+ E + QQ+ L+ LE+ LE E Q+ ++
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 411 -----------YLTETQAKTEVE-----------TREIGVGCDLLPRL-------PFRQN 441
L + Q +TE E +E+ L RL ++
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Query: 442 DSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQN 501
+++ Q + E + +QH DD+ A L + LL ++ + LQKQ
Sbjct: 964 ETTGILQTQLQE-AQRELKEAARQHRDDLAA-----LQEESSSLL--QDKMDLQKQ---- 1011
Query: 502 YEEMQAKLAAQKLAERL 518
E+++++L AQ ++RL
Sbjct: 1012 VEDLKSQLVAQDDSQRL 1028
Score = 69.7 bits (169), Expect = 7e-12
Identities = 92/396 (23%), Positives = 186/396 (46%), Gaps = 37/396 (9%)
Query: 43 EQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN 102
++ ++ E KEQ L E R L Q + + QQ++ G ++KE+ +
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRD-----QELEALQQEQQQAQG-QEERVKEKAD 1841
Query: 103 YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNA 162
++ K +G+ + +++ R+L +EL+V + + LE L A
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE-------EVLGDLRA 1894
Query: 163 MNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQL 222
+ + LQ+ + E+ + + R LQ ++ + L+E+ ++LE + E+Q
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEH---EVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 223 LKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEAN 282
+ + E+++ A AE ++E K ++ + K E+ AE LE + + L+A +A
Sbjct: 1952 SRHQEEAAR-ARAEALQEALGKAHAALQGK--EQHLLEQAELSRSLEASTATLQASLDA- 2007
Query: 283 KKMQAAEISLEEKDQ-RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQ 341
QA LEE + + GE+ R +++ QLQ L + + E+ + +ER Q
Sbjct: 2008 --CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ-----QEREQL 2060
Query: 342 LEEASASLRERIRHLDDMVHCQQKKVKQM-VEEIESLKKKLQQKQLLILQLLEKISFLEG 400
LE+ SL +R++ ++M+ +Q ++ EEI L + +++ QL + Q ++I LE
Sbjct: 2061 LEK---SLAQRVQ--ENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI--LEL 2113
Query: 401 ENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRL 436
+ ++ L+ L + + +E + + + L PRL
Sbjct: 2114 RETQQRNNLEALPHSHKTSPMEEQSLKLD-SLEPRL 2148
Score = 63.5 bits (153), Expect = 5e-10
Identities = 92/422 (21%), Positives = 171/422 (40%), Gaps = 68/422 (16%)
Query: 44 QCEKKI-ERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN 102
Q +K++ + +QL L +KL + G+++ Q Q+E LKE
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE----------LKEAAR 985
Query: 103 YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNA 162
+D A L++ + D ++++++ L +L Q +E +Q + +N
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 163 MNSALASDSIGLQKTLVD------VTLENSNIKDQ-----------IRNLQQTYEASMDK 205
+ L + L +L++ V E +I+ Q + Q+ A M+
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 206 LRE--KQRQLEVAQVENQLLKMKVESS-------------QEANAEVMREMTKKLYSQYE 250
LR+ K+++ + E QLL+ ++E+S QEA A ++ + SQ E
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
E+Q + A+ +A L S L+ QA E + + G D
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQ---------QALGSVCESRPELSGGGDSAPSVWG 1215
Query: 311 KERHQLQLQLLEHE----TEMSGELTDSDKERYQQ----LEEASASLRERIRHLDDMVHC 362
E Q + L T +S E S + Q ++ LR++++ L++ +
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
Query: 363 QQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
+ + Q+ E++ L+++L Q Q E+ S EG+ N L+S L L ET A +
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQ-------EEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 423 TR 424
R
Sbjct: 1329 LR 1330
Score = 62.4 bits (150), Expect = 1e-09
Identities = 105/532 (19%), Positives = 214/532 (40%), Gaps = 124/532 (23%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
+ L+ ++ ++ A L+ + + + +E+++K+ + + + Q E L + Q
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 155 SALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLE 214
L R AL + L+ L V + ++ +Q++ L E L E Q+Q
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 215 VAQVENQLLKMKVES--------------------SQEANAEVMREMTKKLYSQYEEK-- 252
V +V L++++++ ++ + AE R+ + +Q E++
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 253 --LQEEQRKHSAEKEALLEE--------TNSFLKAIEEANKKMQAAEISLEEKDQRIGEL 302
L++++ H E L E+ KA+E ++ E+ L+E+ E+
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT---EM 898
Query: 303 DRLIERMEKERHQLQ--------------LQLLEHETEMSGELTDSDKERYQ-------- 340
+ + + E+ER Q + + LLE + EL D+ ++ +
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
Query: 341 -------------QLEEASASLRERIR-HLDDMVHCQQKK---------VKQMVEEIES- 376
QL+EA L+E R H DD+ Q++ +++ VE+++S
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQ 1018
Query: 377 ---------------------------LKKKLQ-QKQLLILQLLEK---ISFLEGENNEL 405
++K+L+ +K L L L+EK + L+ ++
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 406 QSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE-----ERR 460
Q L L + + + E +E+ +LL R ++ ++ Q++ E E++
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELL-RQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 461 RRDKQHLDDITAARL-LPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAA 511
R + AA+L L L +QL E+LA + QQ N + QA+LA+
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQL----EALAAE-QQPGNQAQAQAQLAS 1184
Score = 62.4 bits (150), Expect = 1e-09
Identities = 74/349 (21%), Positives = 153/349 (43%), Gaps = 41/349 (11%)
Query: 65 RKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDE 124
R+L Q G Q E V KE + +++ LE + + E
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM----E 886
Query: 125 MRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE 184
+ ++++ E+ AQ+E E Q +S+ M + + L +TL+ E
Sbjct: 887 LEMRLKEQQTEMEAIQAQRE--EERTQAESALCQ----MQLETEKERVSLLETLLQTQKE 940
Query: 185 NSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKK 244
++ Q+ L+Q + + KL+E++ +L+ +++ +Q E R+
Sbjct: 941 LADASQQLERLRQ--DMKVQKLKEQET--------TGILQTQLQEAQRELKEAARQHRDD 990
Query: 245 LYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
L + EE Q K +K+ +E+ S L A +++ + + E ++EK + E +R
Sbjct: 991 LAALQEESSSLLQDKMDLQKQ--VEDLKSQLVAQDDSQRLV---EQEVQEKLRETQEYNR 1045
Query: 305 LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQ 364
+ + +E+E+ L L L+E E + L ++D R Q+L ++E Q
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLL-VLQEADSIRQQELSALRQDMQE-----------AQ 1093
Query: 365 KKVKQMVEEIESLKKKLQQKQLLIL----QLLEKISFLEGENNELQSRL 409
+ K++ ++E L++++++K+ L QLLE++ +L++ L
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
Score = 59.3 bits (142), Expect = 9e-09
Identities = 96/514 (18%), Positives = 204/514 (39%), Gaps = 57/514 (11%)
Query: 84 QKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQ- 142
Q+ + + + ++ +EE+ ++ LEK R+ + + +++ QE+ + Q
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
Query: 143 ---------QEYLENHIQTQSSAL----DRFNAMNSALASDSIGLQKTLVDVTLENSNIK 189
E+L +Q + L ++ + + L+ L+++ ++ I+
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 190 DQIRNLQQ------TYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTK 243
Q +Q T E +L E ++E Q +L+K ++E +E + +T
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENHHKMECQQ---KLIK-ELEGQRETQRVALTHLTL 1595
Query: 244 KLYSQYEEKLQEEQRKHSAEKEALL---------EETNSFLKAIEEANKKMQAAEISLEE 294
L + +E + + H E + + +E S + IEE ++ + LE
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 295 KDQRIGELDRLIERMEKERHQLQLQLLEHETEM--------SGELTDSDKERYQQLEEA- 345
+DQ + I+ +E +R + Q ++LE + E ELT + ++ EE
Sbjct: 1656 RDQELMLQKERIQVLEDQRTR-QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
Query: 346 --SASLRERIRHLDDMVHCQQKKV---KQMVEEIESLKKKL-QQKQLLILQLLEKISFLE 399
S + R + H+ ++ ++K+V ++ + E++ LK +L QQ Q L ++ E L
Sbjct: 1715 GPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 400 GENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEER 459
E+ L E + + E++ + + D R +++ Q+ +E
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 460 RRRDK--------QHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAA 511
R ++K + R L Q +EE LA++ ++ Q EE+ L A
Sbjct: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894
Query: 512 QKLAERLNIKMRSYNPEGESSGRYREVRDEDDDW 545
+ + + ++ E R D W
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Score = 57.4 bits (137), Expect = 3e-08
Identities = 101/457 (22%), Positives = 187/457 (40%), Gaps = 90/457 (19%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSV---------------SHAQ 142
KE + ++D R K+ + D ++++ +R+ +EL+ S AQ
Sbjct: 1664 KERIQVLEDQRTRQTKILEE---DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720
Query: 143 QEYLEN----------HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
+ LE+ ++ Q + + L GL + + + +L S + +I
Sbjct: 1721 RGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 193 RNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEK 252
LQQ + Q E +++ Q L+ +++ +Q A A+ +E+ Q + +
Sbjct: 1781 VVLQQ----------QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 253 LQEEQRKHSAEK-EALLEETNSFLKA----IEEANKKMQAAEISLEEKDQRIGELDRLI- 306
QEE+ K A+ + LE+ + LK +++ ++ + E L + +R+ L+ ++
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890
Query: 307 ----ERMEKERHQLQLQ------LLEHETEMSGELTDSD-------KERYQQLEEASASL 349
E E+E+ L LQ EHE E L DS KER Q+LE A
Sbjct: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELEALRAES 1949
Query: 350 RERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL 409
+ RH ++ + + +++ + + + LQ K+ +L+ E LE LQ+ L
Sbjct: 1950 QSS-RHQEEAARARAEALQEALGKAHAA---LQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 410 DYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDD 469
D QA + RQ + + Q+ G + R + D Q L
Sbjct: 2006 D---ACQAHS-------------------RQLEEALRIQE-GEIQDQDLRYQEDVQQLQQ 2042
Query: 470 ITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQ 506
A R L H + +E+SLA Q+ Q+ +E Q
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLA-QRVQENMIQEKQ 2078
Score = 57.0 bits (136), Expect = 4e-08
Identities = 79/404 (19%), Positives = 170/404 (42%), Gaps = 35/404 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V E+ +K ++EQ+ +L T++ + + DQ + + LK++
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR----GQVQDLKKQ 1551
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQK-IRQLTQELSVSHAQQEYLENHIQTQSSALDR 159
+ ++ + LE+ +M E +QK I++L + +L ++ +S L
Sbjct: 1552 LVTLECLALELEENHHKM-----ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 160 FNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE 219
++ L S S L + L + E + ++QI LQ+ E L + ++L + +
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 220 NQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIE 279
Q+L E + +++ E + Q + L+E R+ + +++ + E +
Sbjct: 1667 IQVL----EDQRTRQTKILEEDLE----QIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718
Query: 280 EANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE-HETEMSGELTDSDKER 338
++ ++ L +K++ + I +++ + QL+ QL H L S +E+
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
Query: 339 -----YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLE 393
QQL+EA + + L + Q+ + Q +E+E+L+++ QQ Q ++ E
Sbjct: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 394 KISFLEG-----------ENNELQSRLDYLTETQAKTEVETREI 426
K L+G + ELQ + + + VE R +
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV 1882
Score = 50.8 bits (120), Expect = 3e-06
Identities = 84/431 (19%), Positives = 181/431 (41%), Gaps = 55/431 (12%)
Query: 93 STSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
ST+ L+ ++ + LE+ + G+ + + ++ Q+L + AQ++ H Q
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDV--TLENSNIKDQIRNLQQTYEASMDKLREKQ 210
+ L++ A +Q+ ++ L +++IR L Q+ ++
Sbjct: 2057 REQLLEKSLAQR---------VQENMIQEKQNLGQEREEEEIRGLHQSV---------RE 2098
Query: 211 RQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
QL +AQ E ++L+++ E+ Q N E + +S ++E+ K + + L E
Sbjct: 2099 LQLTLAQKEQEILELR-ETQQRNNLEALP------HSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQ----RIGELDRLIERMEKERHQLQLQLLEHETE 326
L+ ++ A ++ +A EI EK Q + + + +++ LQ +LE ++E
Sbjct: 2152 ----LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
Query: 327 MSG-----ELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL 381
ELT E+ + + S E + V + + + ++K+
Sbjct: 2208 QQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
Query: 382 QQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQN 441
+++L LQ + ++ LE + + LQ L T + E E R+ L R R
Sbjct: 2268 WRQRLEHLQ--QAVARLEIDRSRLQRHNVQLRSTLEQVERERRK-------LKREAMRAA 2318
Query: 442 DSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQN 501
+ S + S ++ R +++ D A L +++ ++ L L+++QKQ+
Sbjct: 2319 QAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL------QKEVVLLQAQLTLERKQKQD 2372
Query: 502 YEEMQAKLAAQ 512
Y A+ + +
Sbjct: 2373 YITRSAQTSRE 2383
Score = 48.5 bits (114), Expect = 2e-05
Identities = 108/591 (18%), Positives = 233/591 (39%), Gaps = 132/591 (22%)
Query: 46 EKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIK 105
+K++ER++ L LS E ++L V++ +D +Q+E+ ++E K
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLL------VLQEADSIRQQELSAL---RQDMQEAQGEQK 1097
Query: 106 DVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLE------------------ 147
++ A +E +R+ + + + QL +EL SH ++ L
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157
Query: 148 ----------------NHIQTQSSALDRFNAMNSALAS---------------------- 169
N Q Q+ ++A+ AL S
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE 1217
Query: 170 -DSIGLQKTL----VDVTLENSNIKDQIRNLQQTY---EASMDKLREKQRQLEVAQVENQ 221
D G + + L + + L Q + + D LR++ ++LE + +
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277
Query: 222 LLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL-LEETNSFLKA-IE 279
K +V + ++++ ++L EEK + E +++S E E + L ET + L++ +
Sbjct: 1278 AEKSQVHTE-------LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR 1330
Query: 280 EAN-KKMQAA---EISLEEKDQRIGELDRLIERMEKERHQLQ--------LQLLEHETEM 327
A ++M+A E+ K+ +++ L + + R Q L+ ++
Sbjct: 1331 RAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKL 1390
Query: 328 SGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLK---KKLQQK 384
E +S++ER Q L+E + + L + + + + + EE+E+L+ ++L+++
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
Query: 385 QLLILQLLEKISF-LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDS 443
+ + LE +S L+ N E+ + + + E + V L LP +
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV-----------LEHLPMAVQER 1499
Query: 444 SSHCQKSGSPISSEERRRRDKQHL-----------DDITAARLLPLHHMPTQLLSIEESL 492
I E+ R ++++ D + ++ + + QL+++ E L
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL-ECL 1558
Query: 493 ALQKQQKQNYEEMQAKLAAQKLAER-----------LNIKMRSYNPEGESS 532
AL+ ++ + E Q KL + +R L+++ RS + +SS
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSS 1609
Score = 38.1 bits (87), Expect = 0.021
Identities = 49/281 (17%), Positives = 123/281 (43%), Gaps = 31/281 (11%)
Query: 196 QQTYEASMDKLREK-QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
++ +E S + ++ K Q LE A++++++ ++ +Q ++ E +K+ E ++
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQ---SQKQNEDYEKMIKALRETVE 314
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
+ H+ L+E S + +E +K+ ++ + + E D + + E
Sbjct: 315 ILETNHTE----LMEHEASLSRNAQE--EKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--------EEASASLRERIRHLDDMVHCQQKK 366
LE ++ + + D ++ L +A LR+++ + V+ Q++
Sbjct: 369 ------LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 367 VKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
Q EE ++L+++LQ +L + L G+ +LQ +D L++ + + E+
Sbjct: 423 HDQWEEEGKALRQRLQ-------KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 427 GVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHL 467
++L + +R + Q G ++ ++++ HL
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 77.4 bits (189), Expect = 3e-14
Identities = 98/461 (21%), Positives = 196/461 (42%), Gaps = 37/461 (8%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
++R Q +KE + + M I +A LEKV + + +E R K+ + +
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTL---ENSNIKDQI 192
L+ Q+ L+ + L+ A+ S L + + + D+ E K+ +
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL 1331
Query: 193 RNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS--QYE 250
+ Q+ D LRE+ + A+ E Q + K AN+EV + TK Q
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEAKAELQRVLSK------ANSEVAQWRTKYETDAIQRT 1385
Query: 251 EKLQEEQRK---HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE 307
E+L+E ++K + E +E N+ ++E+ ++Q L +R ++
Sbjct: 1386 EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1445
Query: 308 RMEKERHQLQLQLLEHETEMSGELTDSDKERYQ---QLEEASASLRERIRHLDDMVHCQQ 364
+ ++ ++ + + E EL S KE +L + + E + HL+ +
Sbjct: 1446 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF----K 1501
Query: 365 KKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
++ K + EEI L ++L + + +L + LE E ELQS L+ E +A E E
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALE---EAEASLEHEEG 1558
Query: 425 EIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQ 484
+I L +L F Q + + + E+ +R ++ +D + + + +
Sbjct: 1559 KI-----LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS-------LDAE 1606
Query: 485 LLSIEESLALQKQQKQNYEEMQAKLA-AQKLAERLNIKMRS 524
S E L ++K+ + + EM+ +L+ A ++A +++S
Sbjct: 1607 TRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1647
Score = 77.4 bits (189), Expect = 3e-14
Identities = 113/582 (19%), Positives = 257/582 (44%), Gaps = 101/582 (17%)
Query: 43 EQCEKKIERKEQL---LDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKE 99
EQ E++ E K +L L +N E + + + R + + K+ + ++ E
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE--E 1404
Query: 100 EMNYIKDVRATLEKVRKRMYGDYDEMRQKI------------RQLTQELSVSHAQQEYLE 147
+ + ++LEK + R+ + +++ + +Q + ++ +Q+Y E
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464
Query: 148 NHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTL---ENSNIKDQIRNL-QQTYEA-- 201
+ + +SS + ++++ L +++L + EN N++++I +L +Q E
Sbjct: 1465 SQSELESSQKEA-RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGK 1523
Query: 202 SMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYE-EKLQEEQRKH 260
++ +L + ++QLEV ++E Q + +EA A + E K L +Q E +++ E +
Sbjct: 1524 NVHELEKVRKQLEVEKLELQ------SALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577
Query: 261 SAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQL 320
AEK+ +E+ A + + + + SL+ + + E+ R+ ++ME + +++++QL
Sbjct: 1578 LAEKDEEMEQ------AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL 1631
Query: 321 LEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDM-------------VHCQQKKV 367
H M+ E K L++ L + +R DD+ + + +++
Sbjct: 1632 -SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1690
Query: 368 KQMVEEIESLKKKLQQK--------QLLILQ---LLEKISFLEGENNELQSRLDYLTETQ 416
+ +VE+ E +K +Q+ QLL Q L+ + +E + +LQS ++ +
Sbjct: 1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 417 AKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLL 476
E + ++ ++ ++ D+S+H ++ + E+ +D QH D A +
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK---KNMEQTIKDLQHRLD--EAEQI 1805
Query: 477 PLHHMPTQLLSIEESL-----ALQKQQKQNYEEMQAK---------------------LA 510
L QL +E + L+ +QK+N E ++ L
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
Query: 511 AQKLAERLNIKMRSYNPEGESS--------GRYREVRDEDDD 544
Q L ++L +K+++Y + E + ++R+V+ E D+
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1907
Score = 65.1 bits (157), Expect = 2e-10
Identities = 95/436 (21%), Positives = 183/436 (41%), Gaps = 55/436 (12%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSA 156
+KEE IK+ TLEK R E+ +K+ L QE + L+ +Q +
Sbjct: 854 MKEEFGRIKE---TLEKSEARR----KELEEKMVSLLQE-------KNDLQLQVQAEQDN 899
Query: 157 LDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVA 216
L+ L + I L+ + ++ N ++D+ + A KL ++ +L+
Sbjct: 900 LNDAEERCDQLIKNKIQLEAKVKEM---NERLEDE-EEMNAELTAKKRKLEDECSELKKD 955
Query: 217 QVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLK 276
+ +L KVE + A ++ +T+++ L E K + EK+AL E L
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAG-----LDEIIAKLTKEKKALQEAHQQALD 1010
Query: 277 AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDK 336
++ K+ + S + +Q++ +L+ +E+ +K R + L+ + + E +LT +
Sbjct: 1011 DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVR--MDLERAKRKLEGDLKLT---Q 1065
Query: 337 ERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKIS 396
E LE L E K+K+ +I K++ +Q+L LQL +K+
Sbjct: 1066 ESIMDLENDKLQLEE--------------KLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 397 FLEGENNELQSRLDYLTETQAKTEVETREIGVGC-DLLPRLPFRQNDSSSHCQKSGSPIS 455
+ EL+ L+ +AK E ++ ++ RL +S + + +
Sbjct: 1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 456 SEERRRRDKQHL---DDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQ 512
++ RRD + + TAA L H +S+A +Q N + ++ KL +
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKH---------ADSVAELGEQIDNLQRVKQKLEKE 1222
Query: 513 KLAERLNIKMRSYNPE 528
K +L + + N E
Sbjct: 1223 KSEFKLELDDVTSNME 1238
Score = 63.9 bits (154), Expect = 4e-10
Identities = 96/484 (19%), Positives = 213/484 (44%), Gaps = 51/484 (10%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIR---QLTQEL 136
D Q +E V S S++K E + D+ +LE+ K++ D + ++K+ +LTQE
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQ-VDDLEGSLEQ-EKKVRMDLERAKRKLEGDLKLTQE- 1066
Query: 137 SVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSI---GLQKTLVDVTLENSNIKDQIR 193
S+ + + L+ + + D N NS + + + LQK L + +++++
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFD-INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELE 1125
Query: 194 NLQQTYEASMDKLR-EKQRQLEVAQVENQL--------LKMKVESSQEANAEVMREMTKK 244
++T A ++KLR + R+LE ++ +L +++++ +EA + MR ++
Sbjct: 1126 -AERTARAKVEKLRSDLSRELE--EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 245 LYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
Q+E ++KH+ L E+ ++ + ++ K+ ++ L++ + ++ +
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1242
Query: 305 LIERMEKERHQLQLQLLEHET---EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVH 361
+EK L+ Q E+ E L D +R +L+ + L ++ + ++
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR-AKLQTENGELARQLEEKEALIS 1301
Query: 362 CQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEV 421
+ +++E LK++L+++ L + + + L R Y ET+AK E+
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLL--REQYEEETEAKAEL 1359
Query: 422 ETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPL--- 478
+ ++ + D+ ++ +R +D + + A+ L
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 479 -HHMPTQ----LLSIEES----LALQKQQ----------KQNYEEMQAKL-AAQKLAERL 518
H + + ++ +E S AL K+Q KQ YEE Q++L ++QK A L
Sbjct: 1420 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1479
Query: 519 NIKM 522
+ ++
Sbjct: 1480 STEL 1483
Score = 60.8 bits (146), Expect = 3e-09
Identities = 95/439 (21%), Positives = 183/439 (41%), Gaps = 70/439 (15%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIR----QLTQELSVSHAQQEYLENHIQT 152
L+E+ + +A L++V + + + R K Q T+EL + ++ L +Q
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA---KKKLAQRLQD 1401
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVD--VTLENSNIKDQIRNLQQTYEASMDK-LREK 209
A++ NA S+L LQ + D V +E SN + +Q + DK L E
Sbjct: 1402 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR---NFDKILAEW 1458
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLE 269
+++ E +Q E +ESSQ+ + E+ K L + YEE L+
Sbjct: 1459 KQKYEESQSE-------LESSQKEARSLSTELFK-LKNAYEESLEH-------------- 1496
Query: 270 ETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE-----HE 324
L+ + NK +Q + + +++GE + + +EK R QL+++ LE E
Sbjct: 1497 -----LETFKRENKNLQE---EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE 1548
Query: 325 TEMSGELTDSDKERYQ-QLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQ 383
E S E + R Q + + A + ++ D+ + Q K+ Q V ++SL+ L
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME-QAKRNHQRV--VDSLQTSLDA 1605
Query: 384 KQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE---------------IGV 428
+ ++L +EG+ NE++ +L + A+ + + + +
Sbjct: 1606 ETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1665
Query: 429 GCDLLPRLPF---RQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQL 485
DL + R N + ++ + + ER R+ + T+ R+ LH T L
Sbjct: 1666 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1725
Query: 486 LSIEESLALQKQQKQNYEE 504
++ ++ + Q Q+ E
Sbjct: 1726 INQKKKMESDLTQLQSEVE 1744
Score = 30.8 bits (68), Expect = 3.4
Identities = 36/164 (21%), Positives = 72/164 (43%), Gaps = 23/164 (14%)
Query: 364 QKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVET 423
+K++ M EE +K+ L++ + +L EK+ L E N+LQ L E + E
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQ--LQVQAEQDNLNDAEE 905
Query: 424 REIGVGCDLLPRLPFR-------QNDSSSHCQKSGSPISSEERRRRD-----KQHLDDIT 471
R CD L + + N+ ++ + +++++R+ D K+ +DD+
Sbjct: 906 R-----CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE 960
Query: 472 AARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLA 515
L L + + + E + ++ +E+ AKL +K A
Sbjct: 961 ----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 1000
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 76.3 bits (186), Expect = 7e-14
Identities = 101/480 (21%), Positives = 205/480 (42%), Gaps = 65/480 (13%)
Query: 85 KEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQ-------LTQELS 137
+E+ VY +LK +N + TL + + DY ++ +K + + L
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340
Query: 138 VSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQ 197
+ L++ + ++L R + S + L++ L +V + ++K + + LQQ
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 198 TYEASMD--------------KLREKQRQLEVA----QVENQLLKMKVESSQEANAEVMR 239
E KL E +RQL A + + QL K+ ++ A++
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
Query: 240 EMTKKLYSQYEEKLQ---------EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEI 290
++++ L Q +EK+ ++ ++ E++AL + T + L+ EA ++
Sbjct: 461 KLSR-LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR---EAQNDLEQVLR 516
Query: 291 SLEEKDQRIGELDRLIER-------MEKERHQL--QLQLLEHETEMSGELTDSDKERYQQ 341
+ +KDQ+I L+ L+++ +EKER L ++Q E ET + +L +E+
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL----QEKNHT 572
Query: 342 LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGE 401
L+E L E++++ + Q+ + V+E ++ + Q + L + + +++ E
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 402 NNELQSRLDYLTETQAKTEV----ETREIGVGCDLLPRLPFRQN---DSSSHCQKSGSPI 454
+ E S+LD + +AKTE+ E + DL L QN D K + +
Sbjct: 633 SKEKVSQLD--IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 455 SSEERRRRDKQ-HLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQK 513
+ +DKQ H + + L + LS+E+ + Q + E ++ A K
Sbjct: 691 DQVTAKLQDKQEHCSQLES----HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746
Score = 69.3 bits (168), Expect = 9e-12
Identities = 77/356 (21%), Positives = 163/356 (45%), Gaps = 36/356 (10%)
Query: 108 RATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSAL 167
RA L+ + +Q++ ++T +L A+ + + H S L + +L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 168 ASDSIGLQ---KTLVDVTLENSNIKDQ-IRNLQQTYEASMD---KLREKQRQLEVAQVEN 220
+ L+ K L +LE K+Q +++LQQ + + D + E +QLE+ +
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 221 QLLKMKVESSQEANAEVMREMTKKLYSQY-----------EEKLQEEQ------------ 257
++ ++ EA + +++TK+ + E K+Q E+
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
Query: 258 RKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKE-RHQL 316
+K EKEAL+ E ++ + + + ++ ++ E+++Q+ +E+ KE +HQL
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
Query: 317 QLQL---LEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE 373
Q+Q+ L+ + E+ L + +KE QL+ S++E++ + + +K+ +Q+
Sbjct: 902 QVQMENTLKEQKELKKSL-EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 374 IESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL-DYLTETQAKTEVETREIGV 428
I LK+ +QK+ I L ++ + EL+++L LT+ + E +I V
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016
Score = 64.3 bits (155), Expect = 3e-10
Identities = 79/340 (23%), Positives = 153/340 (45%), Gaps = 32/340 (9%)
Query: 93 STSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
++ QLK E+N +++ + K+ + +++ I +L Q Q E L+ ++
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQ-- 210
+ L + N LQ+ L E + K++I LQ YE S + ++ Q
Sbjct: 985 --AVLQKTELENK--------LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 211 ---RQLEVAQVENQL--LKMKVESSQE---ANAEVMREMTKKLYSQYEEKLQEEQRKHSA 262
R+ E+ L ++ K+ +QE +N + K + K EQ SA
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ--DSA 1092
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
+KE L+E KA+++ K+ E L + ++ E++ + R EKE +L +L
Sbjct: 1093 KKEQQLQER---CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1149
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
H+ E E+T+ K+ Q L + L+ + L V Q+K+ +Q+++ + +KK
Sbjct: 1150 HKLESIKEITNL-KDAKQLLIQQKLELQGKADSLKAAVE-QEKRNQQILK--DQVKK--- 1202
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
+++ L + +EK + L E E + + E +AK ++
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
Score = 49.3 bits (116), Expect = 9e-06
Identities = 83/382 (21%), Positives = 166/382 (43%), Gaps = 51/382 (13%)
Query: 174 LQKTLVDVTLENSNIKDQIRNLQ--QTYEASMD--------KLREKQRQLEVAQVENQLL 223
LQ +L + + +K ++ Q Q EA D +L+ ++QLE AQ EN +
Sbjct: 95 LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154
Query: 224 KMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANK 283
K + ++ A++ E+ + S+Y+E E + +AE++ + EE NK
Sbjct: 155 KQMKDLFEQKAAQLATEIA-DIKSKYDE---ERSLREAAEQKV--------TRLTEELNK 202
Query: 284 KMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLE 343
+ + E QR G D + ++KE Q+Q L+++ T ++ K+ ++L+
Sbjct: 203 EATVIQDLKTELLQRPGIED--VAVLKKELVQVQ-TLMDNMTLERERESEKLKDECKKLQ 259
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL----QQKQLLILQLLEKISFLE 399
AS I L + ++V V+E++ LK + Q+ Q L LL+K E
Sbjct: 260 SQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK----E 315
Query: 400 GENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKSGSPISSE-E 458
+ +L+ + + + ++ + + + C +L R + S + + +S + E
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ---QLQSRLSASETSLHRIHVELSEKGE 372
Query: 459 RRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERL 518
++ K+ L ++ H+ + ++ Q+Q E+ Q L Q +L
Sbjct: 373 ATQKLKEELSEVET----KYQHLKAE---------FKQLQQQREEKEQHGLQLQSEINQL 419
Query: 519 NIKMRSYNPE-GESSGRYREVR 539
+ K+ + GE+ GR +E R
Sbjct: 420 HSKLLETERQLGEAHGRLKEQR 441
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 75.9 bits (185), Expect = 9e-14
Identities = 107/531 (20%), Positives = 219/531 (41%), Gaps = 86/531 (16%)
Query: 49 IERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVR 108
+E+ ++ + L E R L + + + + ++ Q+KE V + LKEE+ +K
Sbjct: 186 MEKSDEFICLLEQECER-LKKLIDQEIKSQEEKEQEKEKRV-----TTLKEELTKLKSFA 239
Query: 109 ATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALA 168
+ ++R+ RQKI++LT +H + E +Q + R + L
Sbjct: 240 LMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR---LEKELQ 296
Query: 169 SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA---SMDKLREKQRQLEVAQVENQLLKM 225
+ + + + + +N Q R LQQ A +D+L E R L A+ E Q +K
Sbjct: 297 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 356
Query: 226 KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM 285
K+ + NA +M E+ EE RK + E EE + + NK++
Sbjct: 357 KISKGEYGNAGIMAEV-------------EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
Query: 286 QAA-------EISLEEKDQRIGELDRLIERMEKERHQ-----LQLQLLEHETEMSGELTD 333
+ ++ +E+ +RI L++L + K + + L+ T+ + +
Sbjct: 404 ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 463
Query: 334 SDKERYQQLEEASASLRE----------RIRHLDDMVHCQQK----KVKQMVEEIESLKK 379
S K R ++LE + L + +++ L M ++K K+K+ +++++
Sbjct: 464 SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS 523
Query: 380 KLQQKQLLILQLLEKISFLEGENNELQSRLD----YLTETQAKTEVETR---EIGVGCDL 432
+LQ +Q + + EK+ +E L+S+ D + T+ + +++ + E G DL
Sbjct: 524 QLQVEQNKVTTVTEKL--IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 433 LPRL---------------PFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLP 477
L R+ F +N + KS + + E + ++ + +L
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 478 LHHMPTQLLSIEESLALQKQQKQN-----------YEEMQAKLAAQKLAER 517
+ + L+ E+ +++ N E ++ +LA KLAE+
Sbjct: 642 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
Score = 59.7 bits (143), Expect = 7e-09
Identities = 69/361 (19%), Positives = 157/361 (43%), Gaps = 42/361 (11%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYG------DYDEMRQKIRQLTQELSVSHAQQEYLENH 149
+L+ E KD + +EK+ KR+ +++ +Q+ L L + L
Sbjct: 402 RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK 209
+++ + A+ S L L++ L + D+ + + + + + DKL+
Sbjct: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE--------KLQEEQRKHS 261
QL+V Q + + K+ + + ++ +K+YS +E K +EE+
Sbjct: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 262 AEKEALLEETNSFLKAIE------EANKKMQAAEISLEEKDQRIGELDRLIERME---KE 312
+ +L+ L+AIE + N+ + +L +++ +I EL + +ER++ K+
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD-DMVHCQQKKVK-QM 370
++ L++ E E Y+ LE A+ R++ + L ++ H + + K ++
Sbjct: 642 MKAIEDDLMKTEDE------------YETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
Query: 371 VEEIES-----LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
E+ E+ L K+LQ+++ L ++ L+ + +E + D + Q V ++
Sbjct: 690 AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKK 749
Query: 426 I 426
+
Sbjct: 750 L 750
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/310 (21%), Positives = 151/310 (48%), Gaps = 37/310 (11%)
Query: 220 NQLLKMKVESSQEANAEVMREM--TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
N+L K+ VE +E+ ++ ++ +K Q +L+EE+RKH + +E+++ F+
Sbjct: 141 NELDKV-VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH----KEYMEKSDEFICL 195
Query: 278 IE---EANKKMQAAEI-SLEEKDQRIGELDRLIERMEKERHQLQ---LQLLEHETEMSGE 330
+E E KK+ EI S EEK+Q E ++ + +++E +L+ L +++ + ++ +
Sbjct: 196 LEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQ 390
LT +++ Q+L + ++ + V +++K ++ +E+++ K Q Q I
Sbjct: 253 LT-LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI-- 309
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKS 450
+ K++ + +N +LQ +L L+ + E R + + L + ++ S +
Sbjct: 310 -MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI--KEKISKGEYGNA 366
Query: 451 GSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLA-LQKQ-QKQNYEEMQAK 508
G EE R+ R+L + +L+ +EE L K+ +++ + K
Sbjct: 367 GIMAEVEELRK------------RVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
Query: 509 LAAQKLAERL 518
L +KL++R+
Sbjct: 415 LEVEKLSKRI 424
Score = 38.1 bits (87), Expect = 0.021
Identities = 65/288 (22%), Positives = 127/288 (44%), Gaps = 27/288 (9%)
Query: 266 ALLEETNSFL--KAIEEANKK--MQAAEISLEEK--DQRIGELDRLIERMEKERHQLQLQ 319
ALLE F+ K + EA ++ QA +E ++ + ELD+++E+ ++ ++ Q
Sbjct: 101 ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ 160
Query: 320 LLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV-----HCQQKKVKQMVEEI 374
LL E S ++ +LEE +E + D+ + C++ K K + +EI
Sbjct: 161 LLVAE--------KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLK-KLIDQEI 211
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGC-DLL 433
+S ++K Q+K+ + L E+++ L+ + LT + +E+ +
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 434 PRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLA 493
+L + QK+ + + E + + K H D T + L + +Q +++ LA
Sbjct: 272 TKLALAEARVQEEEQKA-TRLEKELQTQTTKFHQDQDTI--MAKLTNEDSQNRQLQQKLA 328
Query: 494 LQKQQKQNYEEMQAKLAAQKLAERL-NIKMRSYNPEGESSGRYREVRD 540
+Q EE L +K E L +IK + E ++G EV +
Sbjct: 329 ALSRQIDELEETNRSL--RKAEEELQDIKEKISKGEYGNAGIMAEVEE 374
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 75.9 bits (185), Expect = 9e-14
Identities = 107/531 (20%), Positives = 219/531 (41%), Gaps = 86/531 (16%)
Query: 49 IERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVR 108
+E+ ++ + L E R L + + + + ++ Q+KE V + LKEE+ +K
Sbjct: 186 MEKSDEFICLLEQECER-LKKLIDQEIKSQEEKEQEKEKRV-----TTLKEELTKLKSFA 239
Query: 109 ATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALA 168
+ ++R+ RQKI++LT +H + E +Q + R + L
Sbjct: 240 LMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR---LEKELQ 296
Query: 169 SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA---SMDKLREKQRQLEVAQVENQLLKM 225
+ + + + + +N Q R LQQ A +D+L E R L A+ E Q +K
Sbjct: 297 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 356
Query: 226 KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM 285
K+ + NA +M E+ EE RK + E EE + + NK++
Sbjct: 357 KISKGEYGNAGIMAEV-------------EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
Query: 286 QAA-------EISLEEKDQRIGELDRLIERMEKERHQ-----LQLQLLEHETEMSGELTD 333
+ ++ +E+ +RI L++L + K + + L+ T+ + +
Sbjct: 404 ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 463
Query: 334 SDKERYQQLEEASASLRE----------RIRHLDDMVHCQQK----KVKQMVEEIESLKK 379
S K R ++LE + L + +++ L M ++K K+K+ +++++
Sbjct: 464 SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS 523
Query: 380 KLQQKQLLILQLLEKISFLEGENNELQSRLD----YLTETQAKTEVETR---EIGVGCDL 432
+LQ +Q + + EK+ +E L+S+ D + T+ + +++ + E G DL
Sbjct: 524 QLQVEQNKVTTVTEKL--IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 433 LPRL---------------PFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLP 477
L R+ F +N + KS + + E + ++ + +L
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 478 LHHMPTQLLSIEESLALQKQQKQN-----------YEEMQAKLAAQKLAER 517
+ + L+ E+ +++ N E ++ +LA KLAE+
Sbjct: 642 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
Score = 59.7 bits (143), Expect = 7e-09
Identities = 69/361 (19%), Positives = 157/361 (43%), Gaps = 42/361 (11%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYG------DYDEMRQKIRQLTQELSVSHAQQEYLENH 149
+L+ E KD + +EK+ KR+ +++ +Q+ L L + L
Sbjct: 402 RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK 209
+++ + A+ S L L++ L + D+ + + + + + DKL+
Sbjct: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE--------KLQEEQRKHS 261
QL+V Q + + K+ + + ++ +K+YS +E K +EE+
Sbjct: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 262 AEKEALLEETNSFLKAIE------EANKKMQAAEISLEEKDQRIGELDRLIERME---KE 312
+ +L+ L+AIE + N+ + +L +++ +I EL + +ER++ K+
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD-DMVHCQQKKVK-QM 370
++ L++ E E Y+ LE A+ R++ + L ++ H + + K ++
Sbjct: 642 MKAIEDDLMKTEDE------------YETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
Query: 371 VEEIES-----LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
E+ E+ L K+LQ+++ L ++ L+ + +E + D + Q V ++
Sbjct: 690 AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKK 749
Query: 426 I 426
+
Sbjct: 750 L 750
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/310 (21%), Positives = 151/310 (48%), Gaps = 37/310 (11%)
Query: 220 NQLLKMKVESSQEANAEVMREM--TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
N+L K+ VE +E+ ++ ++ +K Q +L+EE+RKH + +E+++ F+
Sbjct: 141 NELDKV-VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH----KEYMEKSDEFICL 195
Query: 278 IE---EANKKMQAAEI-SLEEKDQRIGELDRLIERMEKERHQLQ---LQLLEHETEMSGE 330
+E E KK+ EI S EEK+Q E ++ + +++E +L+ L +++ + ++ +
Sbjct: 196 LEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQ 390
LT +++ Q+L + ++ + V +++K ++ +E+++ K Q Q I
Sbjct: 253 LT-LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI-- 309
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLPFRQNDSSSHCQKS 450
+ K++ + +N +LQ +L L+ + E R + + L + ++ S +
Sbjct: 310 -MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI--KEKISKGEYGNA 366
Query: 451 GSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLA-LQKQ-QKQNYEEMQAK 508
G EE R+ R+L + +L+ +EE L K+ +++ + K
Sbjct: 367 GIMAEVEELRK------------RVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
Query: 509 LAAQKLAERL 518
L +KL++R+
Sbjct: 415 LEVEKLSKRI 424
Score = 38.1 bits (87), Expect = 0.021
Identities = 65/288 (22%), Positives = 127/288 (44%), Gaps = 27/288 (9%)
Query: 266 ALLEETNSFL--KAIEEANKK--MQAAEISLEEK--DQRIGELDRLIERMEKERHQLQLQ 319
ALLE F+ K + EA ++ QA +E ++ + ELD+++E+ ++ ++ Q
Sbjct: 101 ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ 160
Query: 320 LLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV-----HCQQKKVKQMVEEI 374
LL E S ++ +LEE +E + D+ + C++ K K + +EI
Sbjct: 161 LLVAE--------KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLK-KLIDQEI 211
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGC-DLL 433
+S ++K Q+K+ + L E+++ L+ + LT + +E+ +
Sbjct: 212 KSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
Query: 434 PRLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLA 493
+L + QK+ + + E + + K H D T + L + +Q +++ LA
Sbjct: 272 TKLALAEARVQEEEQKA-TRLEKELQTQTTKFHQDQDTI--MAKLTNEDSQNRQLQQKLA 328
Query: 494 LQKQQKQNYEEMQAKLAAQKLAERL-NIKMRSYNPEGESSGRYREVRD 540
+Q EE L +K E L +IK + E ++G EV +
Sbjct: 329 ALSRQIDELEETNRSL--RKAEEELQDIKEKISKGEYGNAGIMAEVEE 374
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 75.9 bits (185), Expect = 9e-14
Identities = 82/352 (23%), Positives = 163/352 (46%), Gaps = 55/352 (15%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSS 155
Q+ E+ N +KD+ LE+ R ++ +++ +K + ++ L S +Q +L ++
Sbjct: 274 QITEKENKMKDLTFLLEESRDKV----NQLEEKTKLQSENLKQSIEKQHHLTKELEDIKV 329
Query: 156 ALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQ-----------IRNLQQTYEASMD 204
+L R + AL D KT+ +T E ++ + + T + +
Sbjct: 330 SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE 389
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
LR +Q++LE + + ++L M+++ + EMTK L + E +L EE +K EK
Sbjct: 390 LLRTEQQRLEKNEDQLKILTMELQKKSSE----LEEMTK-LTNNKEVEL-EELKKVLGEK 443
Query: 265 EALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
E LL E F K EE Q EL L++ EKE H L++QL
Sbjct: 444 ETLLYENKQFEKIAEELKGTEQ--------------ELIGLLQAREKEVHDLEIQLT--- 486
Query: 325 TEMSGELTDSDKERYQQLEEASASL-RERIRHLDDMVHCQQKKV--KQMVEEIESLKKKL 381
+T S++ +++++ L E++++ + HC + + K++ +E + +L
Sbjct: 487 -----AITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 382 QQKQLLI-------LQLLEKISFLEGENNELQSRLDYLTE--TQAKTEVETR 424
+ +Q I ++L++I L+ +L++ L+Y+ E Q + EV+ +
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
Score = 55.8 bits (133), Expect = 1e-07
Identities = 97/475 (20%), Positives = 193/475 (40%), Gaps = 73/475 (15%)
Query: 112 EKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDS 171
EK++K E+RQK +L + + AQ++ ++ L N S +
Sbjct: 114 EKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE--------LQFGNEKVSLKLEEG 165
Query: 172 IGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQ 231
I K L+ EN+ + L++T S EK ++ E + E + + M + +
Sbjct: 166 IQENKDLIK---ENNATRHLCNLLKETCARSA----EKTKKYEYEREETRQVYMDLNN-- 216
Query: 232 EANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291
N E M ++L Q E E K + E + + K I + K++ I
Sbjct: 217 --NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQ 274
Query: 292 LEEKDQRIGELDRLIERME------KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEA 345
+ EK+ ++ +L L+E +E+ +LQ + L+ E LT ++LE+
Sbjct: 275 ITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT-------KELEDI 327
Query: 346 SASLRERI---RHLDDMVHCQQKKVKQMVEEIE-------------------------SL 377
SL+ + + L++ + K + Q+ EE E SL
Sbjct: 328 KVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL 387
Query: 378 KKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPRLP 437
++ L+ +Q + + +++ L E + S L+ +T+ EVE E+ +
Sbjct: 388 EELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL--------KKV 439
Query: 438 FRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEES-LALQK 496
+ ++ + K I+ E + +Q L + AR +H + QL +I S K
Sbjct: 440 LGEKETLLYENKQFEKIA--EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSK 497
Query: 497 QQKQNYEEMQ-AKLAAQKLAERLN-IKMRSYNPEGESSGRYREVRDEDDDWSSDE 549
+ K E++ KL +L N + + + E+S E++++ +D ++++
Sbjct: 498 EVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNK 552
Score = 53.9 bits (128), Expect = 4e-07
Identities = 75/350 (21%), Positives = 152/350 (43%), Gaps = 31/350 (8%)
Query: 116 KRMYGDYDEMRQKIRQLTQELSVSHAQQE----YLENHIQTQSSALDRFNAMNSALASDS 171
K + + +M +++ ++++ + Q+E +EN +T++ + + L
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 172 IGLQKTLVDVTLEN-SNIKDQIRN-------LQQTYEASMDKLREKQRQLEVAQVENQLL 223
+ K +D + EN +N++ Q+ N LQQ +A K + +QL V +++ L
Sbjct: 588 DEV-KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKL 646
Query: 224 KMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK-EALLEETNSFLKAIEEAN 282
++++ES+++ E+ K++ ++K+ EE EK + + +E K I++
Sbjct: 647 ELELESAKQKFGEITDTYQKEI---EDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRC 703
Query: 283 KKMQAAEISLEEK-----DQRIGELDR---LIERMEKERHQLQLQLLEHETEMSGELTDS 334
+ A ++L EK D+ I E D L + E+E+ L+ L + + EL
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSV 763
Query: 335 DKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEK 394
K+ + EE RE + + + KK + + E + KL K +
Sbjct: 764 KKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK--AVPSQTVS 821
Query: 395 ISFLEGENNELQSRLDYLTETQAKTEVET---REIGVGCDLLPRLPFRQN 441
+F ++ + + DYL T AK + T + V P+L R+N
Sbjct: 822 RNFTSVDHGISKDKRDYLW-TSAKNTLSTPLPKAYTVKTPTKPKLQQREN 870
Score = 42.4 bits (98), Expect = 0.001
Identities = 75/399 (18%), Positives = 154/399 (38%), Gaps = 71/399 (17%)
Query: 186 SNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESS---QEANAEVMREMT 242
S +K Q T+ S +K E + A+ ++S Q+ N + E
Sbjct: 21 SAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQV 80
Query: 243 KKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGEL 302
Y+E L++ ++S E L + K E+ K + E L +K+ ++ E
Sbjct: 81 GNSDCHYQEGLKDSDLENS---EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQEN 137
Query: 303 DRLIERMEKERHQLQ-------LQLLEHETEMSGELTDSDKERY--QQLEEASASLRERI 353
++IE K +LQ L+L E E + +++ R+ L+E A E+
Sbjct: 138 RKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKT 197
Query: 354 R------------------HLDDMVHCQQK--------------KVKQMVEEIESL---- 377
+ +++ M+ ++ K+K+ E+I+ L
Sbjct: 198 KKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 378 KKKLQQKQ----LLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLL 433
KK++ K+ LL++Q+ EK + ++ L+ D + + + KT++++ + +
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
Query: 434 PRLPFRQNDSSSHCQKSGSPISS---------------EERRRRDKQHLDDITAARLLPL 478
L D Q+S S + E + + + AA +
Sbjct: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
Query: 479 HHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAER 517
T + S+EE L ++Q+ + E+ Q K+ +L ++
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNED-QLKILTMELQKK 415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.331
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,837,449
Number of Sequences: 37866
Number of extensions: 881462
Number of successful extensions: 14508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 508
Number of HSP's successfully gapped in prelim test: 1198
Number of HSP's that attempted gapping in prelim test: 5367
Number of HSP's gapped (non-prelim): 5085
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.