Search of human proteins with 6912482

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912482 leucine zipper-EF-hand containing transmembrane
protein 1 [Homo sapiens]
         (739 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912482 leucine zipper-EF-hand containing transmembrane prote...  1444   0.0  
gi|21389523 leucine zipper-EF-hand containing transmembrane prot...   276   6e-74
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    66   1e-10
gi|67089167 LETM1 domain containing 1 isoform 2 [Homo sapiens]         64   5e-10
gi|67089165 LETM1 domain containing 1 isoform 1 [Homo sapiens]         64   5e-10
gi|71061468 centromere protein E [Homo sapiens]                        63   1e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    62   1e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     61   4e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    58   3e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          57   5e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             56   1e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    56   1e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    56   1e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    56   1e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    56   1e-07
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                56   1e-07
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                56   1e-07
gi|34878904 synaptonemal complex protein 1 [Homo sapiens]              55   2e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    55   3e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    55   3e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    54   4e-07
gi|34878777 ring finger protein 20 [Homo sapiens]                      54   7e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         54   7e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     54   7e-07
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi...    54   7e-07
gi|122891870 melanoma inhibitory activity family, member 3 [Homo...    53   9e-07
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap...    52   2e-06
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C...    52   2e-06
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [...    52   2e-06
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [...    52   2e-06

>gi|6912482 leucine zipper-EF-hand containing transmembrane protein
           1 [Homo sapiens]
          Length = 739

 Score = 1444 bits (3738), Expect = 0.0
 Identities = 739/739 (100%), Positives = 739/739 (100%)

Query: 1   MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP 60
           MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
Sbjct: 1   MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP 60

Query: 61  VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV 120
           VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
Sbjct: 61  VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV 120

Query: 121 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR 180
           EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
Sbjct: 121 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR 180

Query: 181 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF 240
           MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
Sbjct: 181 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF 240

Query: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 300
           ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
Sbjct: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 300

Query: 301 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK 360
           SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
Sbjct: 301 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK 360

Query: 361 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA 420
           LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
Sbjct: 361 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA 420

Query: 421 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 480
           MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
Sbjct: 421 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 480

Query: 481 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI 540
           REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
Sbjct: 481 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI 540

Query: 541 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE 600
           TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
Sbjct: 541 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE 600

Query: 601 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
           ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
Sbjct: 601 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660

Query: 661 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV 720
           KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
Sbjct: 661 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV 720

Query: 721 EEKEKAKEKAEKEVAEVKS 739
           EEKEKAKEKAEKEVAEVKS
Sbjct: 721 EEKEKAKEKAEKEVAEVKS 739


>gi|21389523 leucine zipper-EF-hand containing transmembrane protein
           2 [Homo sapiens]
          Length = 396

 Score =  276 bits (705), Expect = 6e-74
 Identities = 145/276 (52%), Positives = 191/276 (69%), Gaps = 49/276 (17%)

Query: 150 KKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRL 209
           K+S  Q+++DELK+YY+GF LLWID K+AARM+WR+L+G  LTRRERR            
Sbjct: 72  KQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERR------------ 119

Query: 210 VPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIE 269
                                               +EE+ KK++ VKLELAKFLQ+T+ 
Sbjct: 120 ------------------------------------REEKQKKKMAVKLELAKFLQETMT 143

Query: 270 EMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVAL 329
           EMA +N+A  G A+   S + +++ +TG +PS +EI+RFSKLFED+L L++L RPQLVAL
Sbjct: 144 EMARRNRAKMGDASTQLSSYVKQV-QTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVAL 202

Query: 330 CKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGV 389
           CKLLELQ+ GTNN LRFQL M+L+SIKADD++IA+EGV +L+V ELQAACRARGMR+LG+
Sbjct: 203 CKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGL 262

Query: 390 TEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
           TE++LR QL +W DLHL + +P SLL+LSR  YL D
Sbjct: 263 TEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLID 298


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 122/534 (22%), Positives = 217/534 (40%), Gaps = 64/534 (11%)

Query: 247  EERLKKELRVKLELAKF----------LQDTIEEMALKNKAAKGSATKDFSVFFQKIRET 296
            EERLKKE + + EL K           LQD I E+  +    K    K            
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK------------ 1087

Query: 297  GERPSNEEIMRFSKLFEDE-LTLDNLTRPQLVALCKLLELQ-SIGTNNFLRFQLTMRLRS 354
                  EE+       +DE L  +N  +       ++ ELQ    +    R +   + R 
Sbjct: 1088 ----KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143

Query: 355  IKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLK--QWLDLHLHQEIPT 412
            +  + + +  E  D+L+    Q   R +  + +   +  L  + K  +     + Q   T
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203

Query: 413  SLLILSRAMYLPDTL-SPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQ 471
            +L  LS  +       +  ++ K  L+T  + +A E +V + +V+ E    + KL+A +Q
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV-LQQVKAESEHKRKKLDAQVQ 1262

Query: 472  E-------------EAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDT 518
            E             E A +    + EL   S + ++ E + +  A      E Q +    
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322

Query: 519  VLQSET---LKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKED 575
            +LQ ET   L  ++ + +  +E+   +E+ +   +A   L++Q  +L  +  + +   +D
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382

Query: 576  VQDYSEDLQEIKKELSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQA 632
                 E L+E KK+L K  E   ++  E++ A  +L K   ++  ++D L   L+  +Q 
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442

Query: 633  G-----KLAPANGMPTGENVISV--AELINAMKQVKHIPESKLTSLAAALDENKDGKVNI 685
                  K    + +   E  IS   AE  +  +      E+K  SLA AL+E  + K   
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502

Query: 686  DDLVKVIELVDKEDVHISTSQVAEIVATLEK-----EEKVEEKEKAKEKAEKEV 734
            +   K +   D ED+  S   V + V  LEK     E++VEE     E+ E E+
Sbjct: 1503 ERQNKQLR-ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 112/543 (20%), Positives = 223/543 (41%), Gaps = 75/543 (13%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSA---------------TKDFSVFF 290
            K   LK    ++ ++A+  +D   E A +NKA K                  T D +   
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165

Query: 291  QKIRETGERPSNEEIMRFSKLFEDELT-----LDNLTRPQLVALCKLLELQSIGTNNFLR 345
            Q++R   E    +E+    K  E+E       + ++ +    AL +L E   +      +
Sbjct: 1166 QELRTKRE----QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE--QLEQAKRFK 1219

Query: 346  FQLTMRLRSIKADDKLIAEEGVDSLNVK------ELQAACRARGMRALGVTEDRLRGQLK 399
              L    + ++ D+K +A E      VK        +   + + + A     DRLR +L 
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279

Query: 400  QWLDLHLHQEIPTSLLILSRAMYLPDTLSP-ADQLKSTLQTLPEIVAKEAQVKVAEVEGE 458
            +     L  E+     +L  A       +  A  L+S LQ   E++ +E + K+      
Sbjct: 1280 EKAS-KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL------ 1332

Query: 459  QVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDT 518
               N +     L+EE    QE +E+E + R  +      E+ V A Q    + + ++ D 
Sbjct: 1333 ---NLSSRIRQLEEEKNSLQEQQEEEEEARKNL------EKQVLALQSQLADTKKKVDDD 1383

Query: 519  VLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL------- 571
            +   E+L++    L  LK+ E   + ++  + A  KL++ K  L +E ++L +       
Sbjct: 1384 LGTIESLEEAKKKL--LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441

Query: 572  ----LKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLE 627
                L++  + + + L E K   ++  EE+   E++A ++ TK +       + L ++ E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 628  MDQQAGKLAP------ANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDG 681
             ++Q  +L        ++    G+NV  + +   A++Q      ++L  L   L   +D 
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561

Query: 682  KVNIDDLVKVIELVDKEDVHISTSQ-------VAEIVATLEKEEKVEEKEKAKEKAEKEV 734
            K+ ++  ++ ++   + D+     Q       + + V  LE E + E K++A   A K+ 
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 735  AEV 737
             E+
Sbjct: 1622 MEI 1624



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 107/532 (20%), Positives = 221/532 (41%), Gaps = 84/532 (15%)

Query: 241  ETQSLKEERLKKELRVKLELAKFLQD--TIEEMALKNKAAKGSATKDFSVFFQKIRET-- 296
            +TQ L +E  +++L +   + +  ++  +++E   + + A+ +  K       ++ +T  
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378

Query: 297  ------GERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKL--------LELQSIGTNN 342
                  G   S EE  +  KL +D   L      + +A  KL         EL  +  + 
Sbjct: 1379 KVDDDLGTIESLEEAKK--KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436

Query: 343  FLRFQLTMRL-RSIKADDKLIAEEGVDSLNVKE----LQAACRARGMRALGVTEDRLRGQ 397
              + Q+   L +  K  D+L+AEE   S    E     +A  R +  +AL +        
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR-----A 1491

Query: 398  LKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLP------EIVAKEAQVK 451
            L++ L+     E     L       + D +S  D +   +  L       E   +E + +
Sbjct: 1492 LEEALEAKEEFERQNKQLRAD----MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 452  VAEVEGE---QVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPG 508
            + E+E E     D K +LE  +Q   A      E++LQ R E  ++ E +R++    R  
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKA----QFERDLQTRDE--QNEEKKRLLIKQVR-- 1599

Query: 509  TEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEE 568
             E + E+ D        K  A  +   K+ EI  ++++   +A +K +++        ++
Sbjct: 1600 -ELEAELEDE------RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI------KQ 1646

Query: 569  LELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEM 628
            L  L+  ++DY  +L+E     ++   ++   +SK S++  K ++  I Q+     +L  
Sbjct: 1647 LRKLQAQMKDYQRELEE-----ARASRDEIFAQSKESEKKLKSLEAEILQLQ---EELAS 1698

Query: 629  DQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDL 688
             ++A + A        + + + A   +A+   K   E+++  L   L+E +     ++D 
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758

Query: 689  VKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEVKS 739
             +            +T QV  + A L  E    +K + A+++ E++  E+K+
Sbjct: 1759 FRK-----------TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 68/310 (21%), Positives = 135/310 (43%), Gaps = 34/310 (10%)

Query: 442  EIVAKEAQVKVAEVEGEQV----DNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEP 497
            ++  KE +++ A   G+      +N  K+   LQ + A  QE  E E   R++  K  + 
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK--QK 1141

Query: 498  ERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKE--EEITKEEIDILSDACSKL 555
              +    +   TE +  +  T  Q E        +  LK+  EE TK     + D   + 
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201

Query: 556  QEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELS---KTGEEKYVEESKASKRLTKRV 612
                + L+++ E+ +  K +++   + L+   KEL+   K  ++   E     K+L  +V
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261

Query: 613  QQMIGQI-DGLISQLEMDQQAGKLAPANGMPTGENVISVAEL--INAMKQVKHIPESKLT 669
            Q++  ++ +G   ++E+ ++A KL   N +     ++  AE   I   K    + ES+L 
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQ--NELDNVSTLLEEAEKKGIKFAKDAASL-ESQLQ 1318

Query: 670  SLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEK 729
                 L E    K+N+   ++ +E  +K  +                +E+ EE+E+A++ 
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLE-EEKNSL----------------QEQQEEEEEARKN 1361

Query: 730  AEKEVAEVKS 739
             EK+V  ++S
Sbjct: 1362 LEKQVLALQS 1371



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 80/314 (25%), Positives = 137/314 (43%), Gaps = 37/314 (11%)

Query: 446  KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQ 505
            +E    +A++  +Q    + LE  L++E   +QE  EK  +K      D + +      Q
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE-LEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 506  RPGTEPQPEMPDTVLQS-------ETL-KDTAPVLEGLKEEEITKEEIDILSDACS--KL 555
                + Q    +  LQ        ETL K+ A  +    + +I + + D  S+  S  K 
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137

Query: 556  QEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTK----R 611
            ++QK+ L+   EELE LK +++D + D    ++EL    E++  E  KA +  TK    +
Sbjct: 1138 EKQKRDLS---EELEALKTELED-TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193

Query: 612  VQQMIGQIDGLISQLEMDQQAGKLAPAN------GMPTGENVISVAELINAMKQVKHIPE 665
            +Q M  +    + +L    +  K   AN      G+ T    ++    +  ++QVK   E
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE--VKVLQQVKAESE 1251

Query: 666  SKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEK 725
             K   L A + E    KV+  D ++V EL +K           + V+TL     +EE EK
Sbjct: 1252 HKRKKLDAQVQE-LHAKVSEGDRLRV-ELAEKAS---KLQNELDNVSTL-----LEEAEK 1301

Query: 726  AKEKAEKEVAEVKS 739
               K  K+ A ++S
Sbjct: 1302 KGIKFAKDAASLES 1315



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 90/453 (19%), Positives = 183/453 (40%), Gaps = 99/453 (21%)

Query: 353  RSIKAD-DKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLD-LHLHQEI 410
            + ++AD + L++ +     NV EL+     +  RAL    + +R QL++  D L   ++ 
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELE-----KSKRALEQQVEEMRTQLEELEDELQATEDA 1561

Query: 411  PTSLLILSRAMYLPDTLSPADQLKSTLQTLPE-------IVAKEAQVKVAEVEGEQ---- 459
               L +  +AM          Q +  LQT  E       ++ K+ +   AE+E E+    
Sbjct: 1562 KLRLEVNMQAMKA--------QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613

Query: 460  --VDNKAKLEATLQE-EAAIQQEHRE-----KELQKRSEVAKDFEPERVVAAPQRPGTEP 511
              V +K K+E  L++ EA I+  ++      K+L+K     KD++ E   A   R     
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 512  QPEMPDTVLQS---ETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEE 568
            Q +  +  L+S   E L+    +    +     ++E D L+D  +     K +L  EK  
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733

Query: 569  LEL----LKEDVQDYSEDLQEIKKELSKT-------GEEKYVEESKA------------- 604
            LE     L+E++++   +++ +     KT         E   E S A             
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQ 1793

Query: 605  SKRLTKRVQQM------------------IGQIDGLISQLEMDQQAGKLAPANGMPTGEN 646
            +K L  ++Q++                  IGQ++      +++Q+A + A AN +     
Sbjct: 1794 NKELKAKLQELEGAVKSKFKATISALEAKIGQLEE-----QLEQEAKERAAANKL----- 1843

Query: 647  VISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQ 706
               V      +K++    E +        ++ +     +  L + +E  ++E    + S+
Sbjct: 1844 ---VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900

Query: 707  VAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
                    + + ++++  +A E   +EV+ +K+
Sbjct: 1901 -------RKLQRELDDATEANEGLSREVSTLKN 1926



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 53/278 (19%)

Query: 463  KAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS 522
            K  L+ T QEE   + + +++EL K  E     E E      +      +  +    LQ+
Sbjct: 842  KPLLQVTRQEE---ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898

Query: 523  ETLKDTAPVLEGLKEEEITKEEID-ILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSE 581
            ET +  A   E        K+E++ IL D  S+++E+++     + E + ++  +QD  E
Sbjct: 899  ET-ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 582  DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGM 641
             L E +    K   EK   E+K  K                                   
Sbjct: 958  QLDEEEGARQKLQLEKVTAEAKIKK----------------------------------- 982

Query: 642  PTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVH 701
               E ++ + +  +   + K + E ++   ++ L E ++   N+       ++ +K++V 
Sbjct: 983  -MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL------AKIRNKQEVM 1035

Query: 702  ISTSQVAEIVATLEKEEKV-EEKEKAKEKAEKEVAEVK 738
            IS     ++   L+KEEK  +E EKAK K + E  +++
Sbjct: 1036 IS-----DLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068


>gi|67089167 LETM1 domain containing 1 isoform 2 [Homo sapiens]
          Length = 304

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 22/266 (8%)

Query: 164 YYHGFRLLWIDTKIAARM---LWRI-LNGHSLTRRERRQFLRICADLFRLVPFLVFVVVP 219
           +  G ++LW D K A R+   +W+  +  H L  RE     +   D+ + +   +  + P
Sbjct: 33  FMKGLQMLWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPP 92

Query: 220 FMEFLLPVAVKLFPN-MLPSTFETQSLKEERL------KKELRVKLELAKFLQDTIEEMA 272
           F  +L+ + + LFP  +L   F T   + + L      +K+     E+  +L+  I    
Sbjct: 93  FANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHP--EIISYLEKVIP--- 147

Query: 273 LKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDE-LTLDNLTRPQLVALCK 331
           L + A       D     Q+    G  P+  +I+   + F +  L ++ L    + AL +
Sbjct: 148 LISDAGLRWRLTDLCTKIQR----GTHPAIHDILALRECFSNHPLGMNQLQALHVKALSR 203

Query: 332 LLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTE 391
            + L S      LR +L      I   DK +A+ G+  L  +E+++AC  RG+ +  + E
Sbjct: 204 AMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGE 263

Query: 392 DRLRGQLKQWLDLHLH-QEIPTSLLI 416
           DR R  L +WL +    +E   SLL+
Sbjct: 264 DRCRTWLGEWLQISCSLKEAELSLLL 289


>gi|67089165 LETM1 domain containing 1 isoform 1 [Homo sapiens]
          Length = 360

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 22/266 (8%)

Query: 164 YYHGFRLLWIDTKIAARM---LWRI-LNGHSLTRRERRQFLRICADLFRLVPFLVFVVVP 219
           +  G ++LW D K A R+   +W+  +  H L  RE     +   D+ + +   +  + P
Sbjct: 89  FMKGLQMLWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPP 148

Query: 220 FMEFLLPVAVKLFPN-MLPSTFETQSLKEERL------KKELRVKLELAKFLQDTIEEMA 272
           F  +L+ + + LFP  +L   F T   + + L      +K+     E+  +L+  I    
Sbjct: 149 FANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHP--EIISYLEKVIP--- 203

Query: 273 LKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDE-LTLDNLTRPQLVALCK 331
           L + A       D     Q+    G  P+  +I+   + F +  L ++ L    + AL +
Sbjct: 204 LISDAGLRWRLTDLCTKIQR----GTHPAIHDILALRECFSNHPLGMNQLQALHVKALSR 259

Query: 332 LLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTE 391
            + L S      LR +L      I   DK +A+ G+  L  +E+++AC  RG+ +  + E
Sbjct: 260 AMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGE 319

Query: 392 DRLRGQLKQWLDLHLH-QEIPTSLLI 416
           DR R  L +WL +    +E   SLL+
Sbjct: 320 DRCRTWLGEWLQISCSLKEAELSLLL 345


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 112/518 (21%), Positives = 217/518 (41%), Gaps = 37/518 (7%)

Query: 247  EERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIM 306
            EE+LK++ +   E  + L +  EEM+   K  K +  ++     +    T E    E + 
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQK--KINEIENLKNELKNKELTLEHMETERLE 1183

Query: 307  RFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE- 365
               KL E+   + ++T+ + V    L ELQ        R  L   +R I+A      EE 
Sbjct: 1184 LAQKLNENYEEVKSITKERKV----LKELQKSFETE--RDHLRGYIREIEATGLQTKEEL 1237

Query: 366  GVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
             +  +++KE Q             T   +  Q  +     L +EIP   ++      LP+
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP---VLHEEQELLPN 1294

Query: 426  T--LSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREK 483
               +S   +  + L+ L E    +    +A +E E++    K + + +E  ++ +E    
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354

Query: 484  ELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL-----KEE 538
            +  K +   K  + +  +        E Q +   ++   E   +T  ++  +     K+ 
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414

Query: 539  EITKEEIDIL--SDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKEL----SK 592
             + + EI++L  S    +  ++ KS+ KEK++L+ L+E +Q  S+ L+E  KE+     +
Sbjct: 1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLE 1474

Query: 593  TGEEKYV------EESKASKRLTKRVQQMIGQIDGLISQLEM--DQQAGKLAPANGMPTG 644
            T EE  V      E+ +    L   + +   +I  +  QLE   D+   K+         
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534

Query: 645  ENVISVAEL---INAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVH 701
             N+  ++E+   +N +KQ K   ++K ++L +   +  +    + +  + I+++ KE   
Sbjct: 1535 FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594

Query: 702  ISTSQVA-EIVATLEKEEKVEEKEKAKEKAEKEVAEVK 738
            +   Q A +I     KE   E   K KE  EKE   +K
Sbjct: 1595 MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLK 1632



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 76/376 (20%), Positives = 156/376 (41%), Gaps = 55/376 (14%)

Query: 409 EIPTSLLILSRAMYLPDTLSPADQLKS-TLQTLPEIVAKEAQVKVAE-------VEGEQV 460
           E+ T   +L R  Y  + +    QL+  +L+T  + + K+   ++ E       V+ E++
Sbjct: 337 EVSTDEALLKR--YRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKI 394

Query: 461 DNKAKL-----EATLQEEAAIQQEHR------EKELQKRSEVAKDFE-PERVVAAPQRPG 508
           +N  ++       TLQ+E   +++ R      +    K S  A  F  P  +     +  
Sbjct: 395 ENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS 454

Query: 509 TEPQPEMPDTVL-QSETLKDTAPVLEGLKEEEITK--------EEIDILSDACSKLQEQK 559
                E+ ++V  +S+   +T   L  ++    TK         E++ L      L    
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY 514

Query: 560 KSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRV----QQM 615
           + L  EKEE+EL  ++  D  E  + ++++  K  E + + E    K L K      Q +
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDE-FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDL 573

Query: 616 IGQIDGLISQL-EMDQQAGKLAPANGMPTGENV-ISVAELINAMKQVKHIPESKLTSLAA 673
             ++   +  L E + Q  KL         EN+ + ++  + +++  K + ++   +   
Sbjct: 574 ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633

Query: 674 ALDENKDG----KVNIDDLVKVIELVD-----KEDVHISTSQVAEIVATLEKEEKVE-EK 723
           ALD  ++       N++   K+ EL       + D+ +  SQ       LE ++K++ + 
Sbjct: 634 ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ-------LEAKKKMQVDL 686

Query: 724 EKAKEKAEKEVAEVKS 739
           EK  + A  E+ ++ S
Sbjct: 687 EKELQSAFNEITKLTS 702



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 69/336 (20%), Positives = 144/336 (42%), Gaps = 44/336 (13%)

Query: 407  HQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPE---IVAKEAQVKVAEVEGEQVDNK 463
            ++ +   +++LS    LP   S  ++L+  +Q   E   I+  E     +EV  ++   +
Sbjct: 736  NEALREEVILLSELKSLP---SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ 792

Query: 464  AKLEA---TLQEEAAIQQEHR--EKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDT 518
              LE    T  + A  Q  ++  ++E Q    +  DFE +  +        E +    + 
Sbjct: 793  GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLE-----ENERMNQEI 847

Query: 519  VLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQD 578
            V  S+  +     L  LK E         LS    +LQE+ + + +   E+E LKE +++
Sbjct: 848  VNLSKEAQKFDSSLGALKTE---------LSYKTQELQEKTREVQERLNEMEQLKEQLEN 898

Query: 579  YSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPA 638
                LQ +++E +    EK  +  +  K LT+    +    + L  Q+E DQ    +   
Sbjct: 899  RDSTLQTVEREKTLI-TEKLQQTLEEVKTLTQEKDDLKQLQESL--QIERDQLKSDIHDT 955

Query: 639  NGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLV--------- 689
              M    N+ +  +L NA++ +K   E+ + +L + + E     +++++           
Sbjct: 956  VNM----NIDTQEQLRNALESLKQHQET-INTLKSKISEEVSRNLHMEENTGETKDEFQQ 1010

Query: 690  KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEK 725
            K++ +  K+D+    +Q   + A ++  E +E++ K
Sbjct: 1011 KMVGIDKKQDLEAKNTQT--LTADVKDNEIIEQQRK 1044



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 69/331 (20%), Positives = 153/331 (46%), Gaps = 40/331 (12%)

Query: 431  DQLKSTL-QTLPEIVAKEAQVKVAEVE-GEQVDNKAKLEATLQEEAAIQQEHREKELQKR 488
            DQLK  L +T+   + K+ ++K+  +   E  +   KL   + E+   +  + +K+L+  
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN-EISNMQKDLEHS 1761

Query: 489  SEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL---KEEEITKEEI 545
            ++  K  +             + Q E+    +  +  ++T   L G+   K ++++  + 
Sbjct: 1762 NDALKAQD------------LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809

Query: 546  DILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSE---DLQEIKKEL---SKTGEEKYV 599
            D L ++ +KLQE+ + L   + +L  LK+DV +  +   +++++KK++   S T  +  +
Sbjct: 1810 D-LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEI 1868

Query: 600  EESKASKRLTKRVQQM---IGQIDGL-----ISQLEMDQQAGKL--APANGMPTGENVIS 649
            E    +++L + +++M   + + D L       +LE DQ    L    A  +   + + +
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928

Query: 650  VAELINAMKQVKHIPESKLTSLAAAL-DENKDGKVNIDDLVKVIELVDKEDVHISTSQVA 708
               L    K+       K++     + D  KD   + D+L K I+ + K+++ +   +V 
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL--LRVK 1986

Query: 709  EIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
            E V    K  K+ E E+ K++ E +   ++S
Sbjct: 1987 EDVNMSHK--KINEMEQLKKQFEAQNLSMQS 2015



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 69/373 (18%), Positives = 160/373 (42%), Gaps = 57/373 (15%)

Query: 229  VKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSV 288
            +KL  + L  + +    ++  +++EL+    L+K  ++T++++  K  + K     D   
Sbjct: 1901 LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI-SEKTIQISDIQK 1959

Query: 289  FFQKIRETGERPSNEEIMRFSKLF--EDELTLDNLTRPQLVALCKLLELQSIGTNNFL-- 344
               K ++  ++   E   +  +L   ++++ + +    ++  L K  E Q++   +    
Sbjct: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019

Query: 345  RFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWL-- 402
             FQLT +L     + +++A+E  +   +KE           +L +  D+    L++ +  
Sbjct: 2020 NFQLTKKLHESLEEIRIVAKERDELRRIKE-----------SLKMERDQFIATLREMIAR 2068

Query: 403  DLHLHQEIPTSLLILSRAMYLPDTL-SPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVD 461
            D   HQ  P   L+     +L ++L     ++K  L+   E+              +  +
Sbjct: 2069 DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEM-------------DDHYE 2115

Query: 462  NKAKLEATLQEEAAIQQEHREKELQKRSEVAKDF----EPERVVAAPQRPGTEPQPEMPD 517
               +L   L++E   Q   +E  ++ ++ ++  +      E++  A QR   E    M  
Sbjct: 2116 CLNRLSLDLEKEIEFQ---KELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM-- 2170

Query: 518  TVLQSETLKDTAPVLEGLKEEE---ITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
                 + LK     +  +KEE+   I K E+D + +    +++QK+ L K    ++ L++
Sbjct: 2171 -----KKLKYVLSYVTKIKEEQHESINKFEMDFIDE----VEKQKELLIK----IQHLQQ 2217

Query: 575  DVQDYSEDLQEIK 587
            D    S +L+++K
Sbjct: 2218 DCDVPSRELRDLK 2230



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 103/518 (19%), Positives = 222/518 (42%), Gaps = 54/518 (10%)

Query: 235  MLPSTFETQSLKEERLKKELRVKLELAKFLQDT----IEEMALKNKAAKG-----SATKD 285
            +L S  ++   + ERL+KE++ K E    +         E+  K    +G       TKD
Sbjct: 744  ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD 803

Query: 286  FSVFFQKIRETGERPSNEEIMRFSKLFED-----ELTLDNLTR--PQLVALCKLLELQSI 338
                 Q    +  + +++E   F  L  D     ++ L+   R   ++V L K  E Q  
Sbjct: 804  DLATTQ----SNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK--EAQKF 857

Query: 339  GTN-NFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQ 397
             ++   L+ +L+ + + ++   + + E   +   +KE Q   R   ++ +   +  +  +
Sbjct: 858  DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE-QLENRDSTLQTVEREKTLITEK 916

Query: 398  LKQWLDLHLHQEIPTSLLILSRAMYLPDTLS-PADQLKSTLQ-TLPEIVAKEAQVKVA-E 454
            L+Q L+     E+ T          L ++L    DQLKS +  T+   +  + Q++ A E
Sbjct: 917  LQQTLE-----EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 455  VEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPE 514
               +  +    L++ + EE +     R   +++ +   KD   +++V   ++   E +  
Sbjct: 972  SLKQHQETINTLKSKISEEVS-----RNLHMEENTGETKDEFQQKMVGIDKKQDLEAK-- 1024

Query: 515  MPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
              +T   +  +KD   + +  K   + +E+ ++     S + E+++  T  KE +E+  E
Sbjct: 1025 --NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082

Query: 575  DVQDYSEDLQEIKKELSKTGEEK--YVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQA 632
            + ++      E+KK+     +EK   +++     R   R+ ++  ++     QL+  QQ 
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142

Query: 633  GKLAPANGMPTGENVISVAELINAMKQ----VKHIPESKLTSLAAALDENKDGKVNIDDL 688
                        + +  +  L N +K     ++H+ E++   LA  L+EN +   +I   
Sbjct: 1143 LLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM-ETERLELAQKLNENYEEVKSITKE 1201

Query: 689  VKVIELVDK----EDVHISTSQVAEIVAT-LEKEEKVE 721
             KV++ + K    E  H+    + EI AT L+ +E+++
Sbjct: 1202 RKVLKELQKSFETERDHL-RGYIREIEATGLQTKEELK 1238



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 48/200 (24%), Positives = 93/200 (46%), Gaps = 41/200 (20%)

Query: 431  DQLKSTLQTLPEIVA----------KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 480
            ++ K T+Q L + VA          ++ ++K+ +++ E++ N  + E  +    A  +  
Sbjct: 2433 EKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQ 2492

Query: 481  RE-----KELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ--SETLKDTAPVLE 533
            +E     +E  +RS+ A+D     V++      T+PQP          S  +++T  ++ 
Sbjct: 2493 KEVIRLLRENLRRSQQAQDTS---VISEH----TDPQPSNKPLTCGGGSGIVQNTKALI- 2544

Query: 534  GLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL----ELLKEDVQDYSEDLQEIKKE 589
             LK E I  E+        SKL++Q + L K+K EL    + L  +V+ + E  + +K+E
Sbjct: 2545 -LKSEHIRLEK------EISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKE--RTLKRE 2595

Query: 590  LSKTGEEKYVEESKASKRLT 609
              K   +   E S  S ++T
Sbjct: 2596 AHK---QVTCENSPKSPKVT 2612



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 85/443 (19%), Positives = 186/443 (41%), Gaps = 70/443 (15%)

Query: 348  LTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLH 407
            L+ RL+    + K +A+E  D   ++E+           L    D+L+  +K+ +  HL 
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEV-----------LQSESDQLKENIKEIVAKHLE 1474

Query: 408  --QEIPTSLLILSRAMY----LPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVD 461
              +E+  +   L         L   LS  +   ST+Q   E +  + Q K+ E+  ++  
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534

Query: 462  NKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ 521
               K  + +QE+  + +  + KE +K  + A      +++    R   E Q E+   + +
Sbjct: 1535 FNIKQISEVQEK--VNELKQFKEHRKAKDSALQSIESKMLELTNRL-QESQEEIQIMIKE 1591

Query: 522  SETLKDTAPVLEGLKEE--EITKEEIDILSD------------ACSKLQEQKKSLTKEKE 567
             E +K     L+  +++  E TKE +  + +            A ++ QE+   +   KE
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651

Query: 568  ELELLKEDVQDYS-----------EDLQEIKKELSKTGEEKYVEESKASKR--LTKRVQQ 614
            + E  K ++++             E+L+E++    +  + + VEE+   +R  L + +++
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711

Query: 615  MI-----GQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLT 669
             I      Q +  I  + + +    +    G+ + +      E+ N  K ++H  ++   
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEK----TNEISNMQKDLEHSNDALKA 1767

Query: 670  -------SLAAALDENKDGKVNIDDLVKVI-ELVDK-----EDVHISTSQVAEIVATLE- 715
                    L  A    K+ +  ID L  ++ E  DK     +D+  S +++ E +  L+ 
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA 1827

Query: 716  KEEKVEEKEKAKEKAEKEVAEVK 738
             E ++   +K   + +K+V+E++
Sbjct: 1828 NEHQLITLKKDVNETQKKVSEME 1850


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 109/538 (20%), Positives = 231/538 (42%), Gaps = 70/538 (13%)

Query: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 300
           E    + E LK++ +V LE    L+D +E    ++        ++  +  +      ER 
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERD 399

Query: 301 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIK---A 357
            + +  +  +L E+ +TL+            + + QS+  +  L ++L    R+ +   A
Sbjct: 400 MDRK--KIEELMEENMTLE------------MAQKQSMDESLHLGWELEQISRTSELSEA 445

Query: 358 DDKLIAEEGVDSLNVK----ELQAACRARGMRALGVTEDRLRGQLKQWLDLH-------- 405
             K +  E  +  + +    E++     + +  L  T D + G   + L +         
Sbjct: 446 PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505

Query: 406 ----LHQEIPTSLLILSRAMYLP-DTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQV 460
               L  EI      L     L  D +    QL+ T++TL E    E Q+K+ E E E +
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE--NSERQIKILEQENEHL 563

Query: 461 DNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDF--EPERVVAAPQRPGTEPQPEMPDT 518
           +      ++L++ + I  E R K+++K +++  +   E    ++  +    + + E+   
Sbjct: 564 NQTV---SSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620

Query: 519 VLQSETLKDTAPVLEGL-KEEEITKEEIDILSDACSK---LQEQKKSLTKEKEELELLKE 574
             + E  ++    L  L KE E+ +++I  L   C K   L+++   L +E  +L+   +
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680

Query: 575 DVQDYSEDLQEIKKELSKTGEEKYV--EESKASKRLTKRVQQMIGQIDGLISQLEMDQQA 632
             ++ +  L+ ++KE S+  EE        ++ K  + ++ Q+  +   L S+ E  ++ 
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740

Query: 633 GKLAPANGMPTG-----------ENVISVAELINAMKQVKHIPESKLTSLAAALDENKDG 681
            +L  A+   T            EN      L N+ K+++ + ES+L  L     EN+  
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL-ESELQDLEM---ENQTL 796

Query: 682 KVNIDDLV---KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAE 736
           + N+++L    K +E ++KE+       + +  + LEK++K  EKE  + + + E+ +
Sbjct: 797 QKNLEELKISSKRLEQLEKEN-----KSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 68/350 (19%), Positives = 145/350 (41%), Gaps = 40/350 (11%)

Query: 412 TSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKL--EAT 469
           TS  +L   M         ++L++T+ +   +    +++   E E +++  K ++     
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDS---VEGNASKILKMEKENQRLSKKVEILENEI 514

Query: 470 LQEEAAIQQ-EHREKELQK-RSEVAKDFEPERVVAAPQRPGTEPQPE----MPDTVLQSE 523
           +QE+ ++Q  ++  K+L K ++++ K  E  R  +  Q    E + E       ++ Q  
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574

Query: 524 TLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDL 583
            +   A V +  KE +I  E I   S   SK++ +K+ + KE E  +   E  ++   +L
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634

Query: 584 QEIKKE----------LSKTGE--EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ 631
             ++KE          L  T E  E   +E+   +R  +++++ +     L  QLE  ++
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694

Query: 632 AGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKV 691
                    +    NV S+      M Q++               ENK+ +   + L K 
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQL--------------ENKELESEKEQLKKG 740

Query: 692 IELVD---KEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVK 738
           +EL+    K+   +  S     +     ++ +E   K  ++ E E+ +++
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 100/512 (19%), Positives = 207/512 (40%), Gaps = 59/512 (11%)

Query: 236  LPSTFETQSLKEERLKKELR----------VKLELAKFLQDTIEEMALKNKAAKGSATKD 285
            L  T E  + K ++L+ EL+            LE  K     +E++  +NK+ +   T  
Sbjct: 768  LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE-QETSQ 826

Query: 286  FSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLR 345
                 +++ +  +R   +  ++ + L E+ + + NL +          E +++     + 
Sbjct: 827  LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK----------ENKTLSKEIGIY 876

Query: 346  FQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLH 405
             +  +RL+ ++ ++K + +    ++++K L        +R   V+E     Q+   L+  
Sbjct: 877  KESCVRLKELEKENKELVKRA--TIDIKTLVT------LREDLVSEKLKTQQMNNDLEKL 928

Query: 406  LHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAK 465
             H+      + L++   L D  S  D     L++  E   K    K  E++ E++   A 
Sbjct: 929  THE---LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLK----KSLEIKEEKI---AA 978

Query: 466  LEATLQEEAAIQQEHRE--KELQKRSEVAKDFEPER--VVAAPQRPGTEPQPEMPDTVLQ 521
            LEA L+E     Q+ R+  K ++K  E  K  + E   V ++P   G + + E       
Sbjct: 979  LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1038

Query: 522  SETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSE 581
             E LK    ++E  +     + E   L     +L+ Q  +L  +   L+     +Q+ + 
Sbjct: 1039 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1098

Query: 582  DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGM 641
             LQ    + +K   E     S+++  + +  Q +I Q     S LE + ++      +  
Sbjct: 1099 TLQ---TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-----SSLENENESVIKEREDLK 1150

Query: 642  PTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVH 701
               +++I   E +  + + +    S+  SL +     K    N++     +E  D ED +
Sbjct: 1151 SLYDSLIKDHEKLELLHERQ---ASEYESLISKHGTLKSAHKNLE-----VEHRDLEDRY 1202

Query: 702  ISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
                +    +  LEK  KVE+++   E    E
Sbjct: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 70/334 (20%), Positives = 140/334 (41%), Gaps = 37/334 (11%)

Query: 432  QLKSTLQTLPEIVAKEAQVKVAEVEGEQVD--------NKAKLEATLQEEAAIQQEHREK 483
            +LK TL +   +     Q++  E E  Q+D        N   L+    + A +Q E++E 
Sbjct: 674  KLKKTLDSFKNLTF---QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730

Query: 484  ELQKRSEVAKDFE--------PERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGL 535
            E +K  ++ K  E         ER+  + Q    E Q         ++ ++     L+ L
Sbjct: 731  ESEKE-QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789

Query: 536  KEEEITK----EEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELS 591
            + E  T     EE+ I S    +L+++ KSL +E  +LE  K+ ++  ++ L++  +   
Sbjct: 790  EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 592  KTGEEKYVEESKASKRLTKRVQQMIG-QIDGLISQLEMDQQAGKLAPANGMPTGENVISV 650
             T EE  V+     K   K + + IG   +  +   E++++  +L     +     V   
Sbjct: 850  TTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908

Query: 651  AELINAMKQVKHIPE--SKLTSLAAALDENKD----GKVNIDD-----LVKVIELVDKED 699
             +L++   + + +     KLT     +  NK+     + + DD     L   +E   K+ 
Sbjct: 909  EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968

Query: 700  VHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
            + I   ++A + A LE+     ++ + + K  K+
Sbjct: 969  LEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 36/188 (19%), Positives = 87/188 (46%), Gaps = 20/188 (10%)

Query: 452 VAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAK-DFEPE-RVVAAPQRPGT 509
           +  ++G   D KA + A +QE    Q+   + +  + +++++ D EP  + +A   +   
Sbjct: 142 IERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLI 201

Query: 510 EPQPEMPDTVLQSETLKDTAPVLE-------------GLKEEEITKEEIDILSDACSKLQ 556
           + + E  +T+++    +D    L              G+K  E  +     L+DA +K++
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261

Query: 557 EQKKSLTKEKEELELLKEDVQDYSEDLQEIKKE----LSKTGEEK-YVEESKASKRLTKR 611
             ++ L ++ E+L   K++++    +L+ +++E    LS     + Y +E  A +    R
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVR 321

Query: 612 VQQMIGQI 619
           V ++  ++
Sbjct: 322 VDKLESEV 329


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 112/533 (21%), Positives = 210/533 (39%), Gaps = 66/533 (12%)

Query: 247  EERLKKELRVKLELAKF----------LQDTIEEMALKNKAAKGSATKDFSVFFQKIRET 296
            EERL++E + + EL K           L D I E+  +    K    K            
Sbjct: 1033 EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK------------ 1080

Query: 297  GERPSNEEIMRFSKLFEDELTLDNLTRPQLVAL-CKLLELQS-IGTNNFLRFQLTMRLRS 354
                  EE+       E+E    N+   ++  L  ++ ELQ  + +    R +   + R 
Sbjct: 1081 ----KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136

Query: 355  IKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSL 414
            +  + + +  E  D+L+    Q   R++  + + + +  L  + K             S 
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196

Query: 415  LILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEA-QVKVA-EVEGEQVDNKAKLEATLQE 472
             +   A  L  T      L+   QTL     + A +VKV  + +G+    + K+EA LQE
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256

Query: 473  EAAIQQEHREKELQKRSEVAK-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPV 531
                  E      +   +V K   E + V     +  ++      D       L+DT  +
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316

Query: 532  LEGLKEEEIT---------------KEEIDILSDACSKLQEQKKSLTKEKEELELLKEDV 576
            L+    ++++               +E+++   +A   L++Q  +L  +  +++   ED 
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376

Query: 577  QDYSEDLQEIKKELSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAG 633
                E  +E+K++L K  E   +++ E+  A  +L K   ++  ++D L+  L+  +Q+ 
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436

Query: 634  -----KLAPANGMPTGENVISV--AELINAMKQVKHIPESKLTSLAAALDENKDGKVNID 686
                 K    + +   E  IS   AE  +  +      E+K  SLA AL+E  + K  ++
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496

Query: 687  DLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
             L K     + ED+  S   V +          V E EK+K   E++V E+K+
Sbjct: 1497 RLNKQFR-TEMEDLMSSKDDVGK---------SVHELEKSKRALEQQVEEMKT 1539



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 82/359 (22%), Positives = 153/359 (42%), Gaps = 66/359 (18%)

Query: 432  QLKSTLQTLPEIVAK--EAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRS 489
            QL+  LQ   E+ A+  E + ++   + E  +    LEA ++EE   + +H + E +K  
Sbjct: 884  QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEE-RCQHLQAEKKKMQ 942

Query: 490  EVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEG-----LKEEEITKEE 544
            +  ++ E +  +   +    + Q E   T  + + L++   +LE       KE+++ ++ 
Sbjct: 943  QNIQELEEQ--LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 545  IDILSDACSKLQEQKKSLT---------------------KEKEELELLKEDVQDYSEDL 583
            I   +   ++ +E+ KSL                      K+++ELE  +  ++  S DL
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

Query: 584  Q-----------EIKKELSKTGEE-----KYVEESKASKRLT-KRVQQMIGQIDGLISQL 626
                        E+K +L+K  EE       VEE  A K +  K+++++  QI  L   L
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 627  EMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAA--ALDENKDGKVN 684
            E ++ +   A       GE           ++ +K   E  L S AA   L   ++ +VN
Sbjct: 1121 ESERASRNKAEKQKRDLGEE----------LEALKTELEDTLDSTAAQQELRSKREQEVN 1170

Query: 685  I-----DDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEV 737
            I     ++  K  E   +E     +  V E+   LE+ ++V+   EKAK+  E E  E+
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL 1229



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 62/313 (19%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
            E++AKE ++     +    +N+     TLQ +   ++   +++LQ  +E+  + E  R  
Sbjct: 846  EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRAR 905

Query: 502  AAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKS 561
               ++                + L++    LE   EEE          + C  LQ +KK 
Sbjct: 906  LTAKK----------------QELEEICHDLEARVEEE---------EERCQHLQAEKKK 940

Query: 562  LTKEKEELELLKEDVQDYSEDLQ----EIKKELSKTGEEKYVEESKASKRLTKRVQQMIG 617
            + +  +ELE   E+ +   + LQ      + +L K  EE+ + E +  K L K  + +  
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK-LAKEKKLLED 999

Query: 618  QIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDE 677
            +I    + L  +++  K              S+A+L N     KH  E+ +T L   L  
Sbjct: 1000 RIAEFTTNLTEEEEKSK--------------SLAKLKN-----KH--EAMITDLEERLRR 1038

Query: 678  NKDGKVNIDDLVKVIE--LVDKED-VHISTSQVAEIVATLEKEE--------KVEEKEKA 726
             +  +  ++   + +E    D  D +    +Q+AE+   L K+E        +VEE+   
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098

Query: 727  KEKAEKEVAEVKS 739
            K  A K++ E++S
Sbjct: 1099 KNMALKKIRELES 1111



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 109/503 (21%), Positives = 203/503 (40%), Gaps = 74/503 (14%)

Query: 248  ERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMR 307
            ER++ EL  K+   +   D +  +  ++ +     TKDFS    ++++T E    E   +
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

Query: 308  FS-----KLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLI 362
             S     K  EDE    N  R Q       LE +    +N  +   T  L +  AD K  
Sbjct: 1325 LSLSTKLKQVEDE---KNSFREQ-------LEEEEEAKHNLEKQIAT--LHAQVADMKKK 1372

Query: 363  AEEGVDSLNVKELQAACRARGMRALGVT-EDRLRGQLK-QWLDLHLHQEIPTSLLILSR- 419
             E+ V  L   E       + +  L    E+++    K +     L QE+   L+ L   
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432

Query: 420  ---AMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAI 476
               A  L       DQL +  +T+    A+E     AE E  + + KA   A   EEA  
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERD--RAEAEAREKETKALSLARALEEAME 1490

Query: 477  QQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLK 536
            Q+   E+       + K F                + EM D +   + +  +   LE  K
Sbjct: 1491 QKAELER-------LNKQF----------------RTEMEDLMSSKDDVGKSVHELE--K 1525

Query: 537  EEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL-LKEDVQDYSEDLQEIKKELSKTGE 595
             +   +++++ +     +L+++ ++    K  LE+ L+     +  DLQ         G 
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ---------GR 1576

Query: 596  EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISV-AELI 654
            ++  EE K  K+L ++V++M  +++    Q  M   A K    +      ++ S      
Sbjct: 1577 DEQSEEKK--KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634

Query: 655  NAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATL 714
             A+KQ++ + ++++      LD+ +  +  I  L +      KE+     S  AE++   
Sbjct: 1635 EAIKQLRKL-QAQMKDCMRELDDTRASREEI--LAQA-----KENEKKLKSMEAEMI--- 1683

Query: 715  EKEEKVEEKEKAKEKAEKEVAEV 737
            + +E++   E+AK +A++E  E+
Sbjct: 1684 QLQEELAAAERAKRQAQQERDEL 1706



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 43/209 (20%), Positives = 90/209 (43%), Gaps = 29/209 (13%)

Query: 432  QLKSTLQTLPEIVA--KEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRS 489
            +L  T  +  EI+A  KE + K+  +E E +         LQEE A  +  + +  Q+R 
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQ--------LQEELAAAERAKRQAQQERD 1704

Query: 490  EVAKDF------------EPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKE 537
            E+A +             E  R+ A   +   E + E  +T L ++ LK     ++ +  
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764

Query: 538  E-EITKEEIDILSDACSKLQEQKKSLTKEKEELE-----LLKEDVQDYSEDLQEIKKELS 591
            +  + +       +A  +L+ Q K L  + +E+E       K  +      + +++++L 
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD 1824

Query: 592  KTGEEKYVEESKASKRLTKRVQQMIGQID 620
               +E+     K  +R  K+++ ++ Q+D
Sbjct: 1825 NETKERQA-ACKQVRRTEKKLKDVLLQVD 1852


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 66/291 (22%), Positives = 134/291 (46%), Gaps = 18/291 (6%)

Query: 450 VKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509
           +K  + EG Q  N     + +++E  + Q HR  E Q+++E  ++ E  R V        
Sbjct: 464 MKELDEEGNQRRNLESTVSQIEKEKMLLQ-HRINEYQRKAE--QENEKRRNVENEVSTLK 520

Query: 510 EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL 569
           +   ++      S+   +    L+  K+ E   + +   SD   +L++    ++K   +L
Sbjct: 521 DQLEDLKKVSQNSQLANEKLSQLQ--KQLEEANDLLRTESDTAVRLRKSHTEMSKSISQL 578

Query: 570 ELLKEDVQDYSEDLQEIKKELSKTGEEKYVEES--KASKRLTKRVQQMIGQIDGLISQLE 627
           E L  ++Q+ +  L+  K   S+T ++ Y  ++  +A +R      +MIG +   I+ L+
Sbjct: 579 ESLNRELQERNRILENSK---SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQ 635

Query: 628 MDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDD 687
             ++   L        GE      +++N  ++ K+  E  L     +L +  + +VN   
Sbjct: 636 --EEVKHLKHNLEKVEGERK-EAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHK 692

Query: 688 LVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVK 738
           + K   L DK      + + A+ VA  E E+K++E+ +A+EKAE  V +++
Sbjct: 693 VTKA-RLTDKHQ----SIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 114/523 (21%), Positives = 216/523 (41%), Gaps = 63/523 (12%)

Query: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGS--ATKDFSVFFQKIRETGE 298
           E Q   E+  +K   V+ E++  L+D +E++    K ++ S  A +  S   +++ E  +
Sbjct: 497 EYQRKAEQENEKRRNVENEVST-LKDQLEDL---KKVSQNSQLANEKLSQLQKQLEEAND 552

Query: 299 --RPSNEEIMRFSK----LFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRL 352
             R  ++  +R  K    + +    L++L R +L    ++LE     T+    +QL   L
Sbjct: 553 LLRTESDTAVRLRKSHTEMSKSISQLESLNR-ELQERNRILENSKSQTDKDY-YQLQAIL 610

Query: 353 RSIKADDKLIAEEGVDSLNVKELQAACRA--RGMRALGVTEDRLRGQLKQWLDLHLHQEI 410
            + + D       G DS  + +LQA   +    ++ L    +++ G+ K+  D+  H E 
Sbjct: 611 EAERRD------RGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEK 664

Query: 411 PTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL 470
             + L +              +LKS  Q L + V +    K    +  Q   +AK  A  
Sbjct: 665 EKNNLEIDLNY----------KLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMC 714

Query: 471 QEEAAIQQEH--REKELQKRSEVAKDFE-------------------PERVVAAPQRPGT 509
           + E  +++E   REK   +  ++ K                       ER+    +    
Sbjct: 715 EMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTL 774

Query: 510 EPQPEMPDTVLQSETLKDTAPVLEGLKE-EEITKEEIDILSDACSKLQEQKKSLTKEKEE 568
           + + E    +L    LK  A   + LK  E+  K+EI+ L +A   L+ +   LTK+   
Sbjct: 775 QLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRG 834

Query: 569 LELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLT-KRVQQMIGQIDGLISQLE 627
            E    ++QD  E  ++    L KT  ++  EE +   R   K++Q++  + + L +QL+
Sbjct: 835 NEGQMRELQDQLE-AEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD 893

Query: 628 MDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDD 687
           +   A   A +  +  G       EL    K+       ++T     +   ++       
Sbjct: 894 L---AETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEAN---SM 947

Query: 688 LVKVIELVDKEDVHISTS-QVAEIVATLEKEEKVEEKEKAKEK 729
           L K IE++ +E+  ++   + AE    LEKEE++   + A EK
Sbjct: 948 LTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEK 990



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 72/381 (18%), Positives = 173/381 (45%), Gaps = 29/381 (7%)

Query: 244 SLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNE 303
           SL+EE   K L+  LE  +  +   ++M   ++  K +   D +   + +++  E+  NE
Sbjct: 633 SLQEE--VKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNE 690

Query: 304 EIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIA 363
             +  ++L +   +++     + VA+C++ +          + +     R  KA+++++ 
Sbjct: 691 HKVTKARLTDKHQSIEEA---KSVAMCEMEK----------KLKEEREARE-KAENRVVQ 736

Query: 364 EEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLI---LSRA 420
            E   S+   +L+ +   + +  L   ++R+  ++K  L L L QE    LL+   L   
Sbjct: 737 IEKQCSMLDVDLKQS--QQKLEHLTGNKERMEDEVKN-LTLQLEQESNKRLLLQNELKTQ 793

Query: 421 MYLPDTLSPAD-QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQE 479
            +  D L   + Q+K  + TL E   +  + ++A++  +   N+ ++   LQ++   +Q 
Sbjct: 794 AFEADNLKGLEKQMKQEINTLLE-AKRLLEFELAQLTKQYRGNEGQMRE-LQDQLEAEQY 851

Query: 480 HREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ-SETLKDTAPVLEGLKEE 538
                  +  E+ ++ E +      +    + + E   T L  +ET  ++  +  GL EE
Sbjct: 852 FSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEE 911

Query: 539 ---EITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGE 595
              E+T+E     S    ++ ++  ++++ +E   +L +D++    + +E+ +++ K  E
Sbjct: 912 QYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEE 971

Query: 596 EKYVEESKASKRLTKRVQQMI 616
           E  +E+ +    L    ++ I
Sbjct: 972 EYKLEKEEEISNLKAAFEKNI 992


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 73/316 (23%), Positives = 134/316 (42%), Gaps = 43/316 (13%)

Query: 438 QTLPEIVAKEAQVK---------VAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQK- 487
           +T P +  KE   K         VAE +   V  KA  E T+++E  ++ E +++E +K 
Sbjct: 597 ETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP 656

Query: 488 RSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDI 547
           + EVAK  +   +    +    E + E+   + + E  +    V +    +E+ KE    
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEV--- 713

Query: 548 LSDACSKLQEQKKSLTKE----KEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESK 603
                   +E+KK + KE    K+E++ L +D +  S  L E KK  +   +    EES 
Sbjct: 714 -------KKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766

Query: 604 ASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHI 663
               +     +  G+I       ++ ++ GK A A     G    + A  + A   +  I
Sbjct: 767 KKDSVAAGKPKEKGKI-------KVIKKEGKAAEAVAAAVGTGATTAA--VMAAAGIAAI 817

Query: 664 PESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEK 723
             +K       L+  +    + +DL K  E +  E+V + T  +   +  +E EEK++E 
Sbjct: 818 GPAK------ELEAERSLMSSPEDLTKDFEELKAEEVDV-TKDIKPQLELIEDEEKLKET 870

Query: 724 EKAKE---KAEKEVAE 736
           E  +    + E+EV +
Sbjct: 871 EPVEAYVIQKEREVTK 886



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/211 (22%), Positives = 93/211 (44%), Gaps = 24/211 (11%)

Query: 409 EIPTSLLILSRAMYLPDTLSPADQLKSTLQTLP-EIVAKEAQVKVAEV-EGEQVDNKAKL 466
           ++PT ++  ++     D+    + LK   + LP + V KE++ +  EV +   V+   K+
Sbjct: 524 QVPTPVVKQTKLKQRADS---RESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKV 580

Query: 467 EATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLK 526
           E+            +EK + K+ +  K      V         EP P   +   +  T  
Sbjct: 581 ES------------KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQAT-- 626

Query: 527 DTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEI 586
           D  P  +  KE+ + KE      D   + ++ KK + K++++  + KE+     E  +E+
Sbjct: 627 DVKP--KAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEV 684

Query: 587 KKELSKTGE---EKYVEESKASKRLTKRVQQ 614
           KKE+ K  +   +K V++    K + K V++
Sbjct: 685 KKEIKKEEKKEPKKEVKKETPPKEVKKEVKK 715


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 86/413 (20%), Positives = 175/413 (42%), Gaps = 60/413 (14%)

Query: 354 SIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTS 413
           ++K DD  +  +      V++LQA+ +     +     + L+ +L+++  L   +  P  
Sbjct: 79  ALKRDDVTLLRQ-----EVQDLQASLKEEKWYS-----EELKKELEKYQGLQQQEAKPDG 128

Query: 414 LLILSRA--MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQ 471
           L+  S A    L   L  A      ++ + ++  ++A     E+    + +K   E +L+
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA--DIKSKYDEERSLR 186

Query: 472 EEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPV 531
           E A  +     +EL K + V +D + E +    QRPG E    +   ++Q +TL D    
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELL----QRPGIEDVAVLKKELVQVQTLMDNM-T 241

Query: 532 LEGLKEEEITKEEIDILSDACSKLQEQ----KKSLTKEKEELELLKEDVQDYSEDLQEIK 587
           LE  +E E  K+E       C KLQ Q    + ++++ + EL    ++V  Y ++LQ++K
Sbjct: 242 LERERESEKLKDE-------CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294

Query: 588 KELSKTG--------------------EEKYVEESKASKRLTKRVQQMIGQIDGLISQLE 627
             +++                      EEK+ EES + K +   + Q       L S+L 
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354

Query: 628 MDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDD 687
             + +           GE    + E ++ ++      +++   L    +E +   + +  
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414

Query: 688 LVKVI--ELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVK 738
            +  +  +L++ E       Q+ E    L KE++    EK  +K E++VA+++
Sbjct: 415 EINQLHSKLLETE------RQLGEAHGRL-KEQRQLSSEKLMDK-EQQVADLQ 459



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 118/528 (22%), Positives = 222/528 (42%), Gaps = 88/528 (16%)

Query: 245 LKEERLKKELRVKL--------ELAKFLQDTIEEMALKNK--AAKGSATKDFSVFFQKIR 294
           LK  RL+++L+ K+        +L K  Q   E+ AL+    A    A  D     ++I 
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519

Query: 295 ETGERPSN-EEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLR-------- 345
           +  ++  N E +++ SK   + ++L    R  L A  +  E ++   N            
Sbjct: 520 DKDQKIQNLEALLQKSK---ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576

Query: 346 -FQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGV--TEDRLRGQLKQWL 402
             QLT +L++     K   E   D   V+E +A  RA   R L +  + + L  QL +  
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQ--VQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634

Query: 403 D----LHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGE 458
           +    L +  +  T LL+ + A     T   AD     LQ   +      Q K  E+   
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAA---KTAQRAD-----LQNHLDTAQNALQDKQQELN-- 684

Query: 459 QVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDT 518
                 K+   L +  A  Q+ +E   Q  S + K+++ + +    +    E Q +    
Sbjct: 685 ------KITTQLDQVTAKLQDKQEHCSQLESHL-KEYKEKYLSLEQKTEELEGQIKK--- 734

Query: 519 VLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQD 578
            L++++L+  A   + L++    +++  + +D   +  E  K L  EKE +   + D+Q 
Sbjct: 735 -LEADSLEVKASKEQALQD---LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790

Query: 579 YSEDLQEIKKELSKTGEEKYV---------EESKAS-KRLTKRVQQMIGQIDGLISQLEM 628
            SE L+ IK++L+K  EEK +         +E+K   + L  R+Q  + +    + +++M
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKVKM 846

Query: 629 DQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDL 688
           +++A                 + EL     ++  + +S   S +    EN+ GK  I DL
Sbjct: 847 EKEA----------------LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890

Query: 689 VKVI-ELVDKEDVHISTS--QVAEIVATLEKEEKVEEKEKAKEKAEKE 733
            K   EL  +  V +  +  +  E+  +LEKE++   + K +  + +E
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 96/529 (18%), Positives = 214/529 (40%), Gaps = 44/529 (8%)

Query: 242  TQSLKEERLKKEL----RVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETG 297
            T+  K+  ++KE+    R+ L+      ++I++   K +  K    +DF    Q+ +   
Sbjct: 768  TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827

Query: 298  ERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQL-TMRLRSIK 356
            E  +N      ++L + ++  + L         KL ++     N+   F+    + ++  
Sbjct: 828  EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887

Query: 357  ADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLI 416
             D +   +E    L V+        + ++     E     QLK  L+    Q I     +
Sbjct: 888  LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947

Query: 417  LSRAMYLPDTLSPADQLK-STLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL----- 470
                          ++LK S+ Q   +I A + ++K+A ++  +++NK + + T      
Sbjct: 948  KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007

Query: 471  ---QEEAAIQQEHREKELQKRSEVAKDF---EPERVVAAPQRPGTEPQPEMP--DTVLQS 522
               +E+ ++ Q + EK  +   ++  DF   E E +         E +  +   D +   
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067

Query: 523  ETLKDTAPVLEGLKEEEITKEEIDI-----LSDACSKLQEQKKSLTKEKEELELLKEDVQ 577
              + +   +++ LK  + T E+        L + C  LQ+ +K  + +++EL   K  + 
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127

Query: 578  DYSEDLQEIKKELSKTGEEKYVEESKASKRLT--KRVQQMIGQIDGLISQLEMDQQAGKL 635
            +  E     +KE++K  EE    + ++ K +T  K  +Q++ Q      +LE+  +A  L
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ-----QKLELQGKADSL 1182

Query: 636  APANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELV 695
              A         I   ++    +++K     K   L + + E + G    ++        
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE-------- 1234

Query: 696  DKEDVHISTSQVAEIVATLEKE-----EKVEEKEKAKEKAEKEVAEVKS 739
            ++  + +  + + E + T++KE      +V E EK  +    E+A +++
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA 1283



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 85/387 (21%), Positives = 163/387 (42%), Gaps = 56/387 (14%)

Query: 403  DLHLHQEIPTSLLILSRAMYLPDTLSPADQLKST----LQTLPEIVAKEAQVKVAEVEGE 458
            DL   +++ T L +  RA  L   L    ++ S+    LQ   E +    Q K+ + E E
Sbjct: 752  DLQQQRQLNTDLEL--RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ-KLTKQEEE 808

Query: 459  QVDNKAKLEATLQEEAAIQQEHREKELQKR-SEVAKDFEPERVVAAPQRPGTEPQPEMPD 517
            +   K   E TL +E  IQ E     +Q   +E+ K    +  +        +   ++ D
Sbjct: 809  KQILKQDFE-TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD 867

Query: 518  TVLQS------ETLKDTAPVLEGLKEEEITKEEIDI-LSDACSKLQEQKKSLTKEKEELE 570
            ++  S      E  K  A +L+  K  +  K ++ + + +   + +E KKSL KEKE   
Sbjct: 868  SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927

Query: 571  LLKEDVQDYSEDLQEIKKELSKTGEEKYV------EESKASKRLTKRVQQMIGQIDGLI- 623
             LK ++    E L + +  L +  +E+        E  ++S++  K+++ + G++   + 
Sbjct: 928  QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987

Query: 624  --SQLEMDQQAGKLAPANGMPTGENVISV-----------------------AELINAMK 658
              ++LE   Q      A  +   +  ISV                       +EL+   +
Sbjct: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047

Query: 659  QVKHIPESKLTSLAAALDENKDGKVNIDDLV---KVIELVDKEDVHISTSQVAE---IVA 712
             +K + E KL+     L  N++   N + L+   K  +   ++D      Q+ E    + 
Sbjct: 1048 DLKSV-EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106

Query: 713  TLEKEEKVEEKEKAKEKAE-KEVAEVK 738
             ++KE+ ++EKE   EK++  E+ E+K
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIK 1133



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 41/190 (21%), Positives = 80/190 (42%), Gaps = 23/190 (12%)

Query: 559 KKSLTKEKEELELLKEDVQDYSEDL-------QEIKKELSKTGEEKYVEESKASKRLTKR 611
           + +L  +++++ LL+++VQD    L       +E+KKEL     EKY    +   +    
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL-----EKYQGLQQQEAKPDGL 129

Query: 612 VQQMIGQIDGLISQLEMDQ-------QAGKLAPANGMPTGENVISVAELINAMKQVKHIP 664
           V     ++  L  QLE  Q       Q   L           +  +    +  + ++   
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189

Query: 665 ESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKE--EKVEE 722
           E K+T L   L  NK+  V  D   ++++    EDV +   ++ ++   ++    E+  E
Sbjct: 190 EQKVTRLTEEL--NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE 247

Query: 723 KEKAKEKAEK 732
            EK K++ +K
Sbjct: 248 SEKLKDECKK 257



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 72/326 (22%), Positives = 139/326 (42%), Gaps = 41/326 (12%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEA-AIQQEHREKELQKRSE 490
           QL S      E    + Q+K++ +E EQ+  K      LQ +    +Q+H+E++  ++S 
Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLE-EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500

Query: 491 VAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSD 550
            AK  E +  +    R   +   ++ +     +  K+   +LE  +E+   K +      
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560

Query: 551 AC-SKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLT 609
           A  ++LQE+  +L   +E++  L E +++ SE  ++ ++ L        V+E KA  R  
Sbjct: 561 AVLNQLQEKNHTL---QEQVTQLTEKLKNQSESHKQAQENL-----HDQVQEQKAHLRAA 612

Query: 610 K-RVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKL 668
           + RV  +   ++ L SQL   +              E V  +   I A  ++    E+  
Sbjct: 613 QDRVLSLETSVNELNSQLNESK--------------EKVSQLDIQIKAKTELLLSAEAAK 658

Query: 669 TSLAAALDENKDGKVNI-----DDLVKVIELVDKEDVHISTSQ--VAEIVATLEK----- 716
           T+  A L  + D   N       +L K+   +D+    +   Q   +++ + L++     
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY 718

Query: 717 ---EEKVEEKEKAKEKAEKEVAEVKS 739
              E+K EE E   +K E +  EVK+
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKA 744


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 109/526 (20%), Positives = 216/526 (41%), Gaps = 72/526 (13%)

Query: 241  ETQSLKEERLKKELRVKLELAKF------LQDTI-EEMALKNKAAKGSAT---------- 283
            +TQ L +E  +++L V  +L +       LQD + EEM  K    +  +T          
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378

Query: 284  --KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTN 341
              +DF+   + + E G++   +EI   ++ +E++    +        L + L+   +  +
Sbjct: 1379 KLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 342  NFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKE---LQAACRARGMRALGVTEDRLRGQL 398
            N  +    +  +  K D  L  E+ + S    E    +A  R +  +AL +        L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-----AL 1492

Query: 399  KQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIV-AKEAQVKVAEVEG 457
            ++ L+     E    +L       + D +S  D +   +  L +   A E Q++  + + 
Sbjct: 1493 EEALEAKEELERTNKMLKAE----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 458  EQVDNKAKLEATLQEEAAIQQEHREKELQ---KRSEVAKDFEPERVVAAPQRPGTEPQPE 514
            E+++++  L+AT  E+A ++ E   + L+   +R   A+D + E      QR   E + E
Sbjct: 1549 EELEDE--LQAT--EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604

Query: 515  MPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
            + D   Q          LEG        +++++ +D+  K +E+     K+  +L+   +
Sbjct: 1605 LEDERKQRALAAAAKKKLEG------DLKDLELQADSAIKGREEA---IKQLRKLQAQMK 1655

Query: 575  DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK 634
            D Q   ED +  + E+  T +E      K +K L   + Q       L   L   ++A K
Sbjct: 1656 DFQRELEDARASRDEIFATAKEN----EKKAKSLEADLMQ-------LQEDLAAAERARK 1704

Query: 635  LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIEL 694
             A        E + S     NA++  K   E+++  L   L+E +     + D V+    
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--- 1761

Query: 695  VDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEVKS 739
                    +T Q  ++   L  E    +K E A+++ E++  E++S
Sbjct: 1762 --------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 116/517 (22%), Positives = 199/517 (38%), Gaps = 96/517 (18%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEI 305
            K   LKK   ++  ++   +D   E A +NKA                 E  +R   EE+
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKA-----------------EKQKRDLGEEL 1148

Query: 306  MRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE 365
                   ED  TLD+    Q        EL++       R Q    L+    ++    E 
Sbjct: 1149 EALKTELED--TLDSTATQQ--------ELRA------KREQEVTVLKKALDEETRSHEA 1192

Query: 366  GVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
             V  +  K  QA              + L  QL+Q+                 RA     
Sbjct: 1193 QVQEMRQKHAQAV-------------EELTEQLEQF----------------KRAK---- 1219

Query: 426  TLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKEL 485
              +  D+ K TL+     +A E +V + + + E    K KLEA +QE  +   +      
Sbjct: 1220 --ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276

Query: 486  QKRSEVAK-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT--- 541
            +   +V K   E E V         +      D    S  L+DT  +L+    +++    
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336

Query: 542  -----KEEIDILSDACSKLQEQKKSLTKEKEELEL----LKEDVQDYS---EDLQEIKKE 589
                 +EE + L D   +  E K++L +    L +     K+ +QD++   E L+E KK 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 590  LSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ-----AGKLAPANGM 641
              K  E   ++Y E++ A  +L K   ++  ++D L+  L+  +Q       K    + +
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 642  PTGENVIS--VAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKED 699
               E  IS   A+  +  +      E+K  SLA AL+E  + K  ++   K+++  + ED
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-AEMED 1515

Query: 700  VHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAE 736
            +  S   V + V  LEK ++  E +  + K + E  E
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 74/340 (21%), Positives = 143/340 (42%), Gaps = 49/340 (14%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
            E+ AKE +++  +   ++ +N+ K       +   ++   +++LQ  +E+  + E  RV 
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 502  AAPQRPGTE----------PQPEMPDTVLQSETLKDTAPVL---EGLKEEEITKEEIDI- 547
             A ++   E           + E     LQ+E  K    +L   E L+EEE  ++++ + 
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 548  ----------LSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG--- 594
                      L D    + +Q   L+KE++ LE    D+     + +E  K L+K     
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 595  -------EEKYVEESKASKRLTKRVQQMIG-------QIDGLISQL-EMDQQAGKLAPAN 639
                   E +  +E K+ + L K  +++ G       QI  L +Q+ E+  Q  K     
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092

Query: 640  GMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNID----DLVKVIELV 695
                      +A+  NA+K+++ + E  ++ L   LD  +  +   +    DL + +E +
Sbjct: 1093 QAALARLDDEIAQKNNALKKIREL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 696  --DKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
              + ED   ST+   E+ A  E+E  V +K   +E    E
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 54/225 (24%), Positives = 101/225 (44%), Gaps = 39/225 (17%)

Query: 536  KEEEI--TKEEIDILSDACSKLQEQKKSLTKEKEEL-ELLKEDVQDYSE----------- 581
            KE+E+  TKE      +   +L+++   LT+EK  L E L+ + + Y+E           
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 582  --DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK----- 634
              +L+EI  E+    E +  EE    ++L    ++M  Q+  L  QLE ++ A +     
Sbjct: 917  KQELEEILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 635  --LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVI 692
               A A      + ++ + +  N + + + + E +++ L   L E ++   N+  L    
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 693  ELVDKEDVHISTSQVAEIVATLEKEEKV-EEKEKAKEKAEKEVAE 736
            E           S ++E+   L+KEEK  +E EK K K E + ++
Sbjct: 1033 E-----------SMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 39/202 (19%), Positives = 94/202 (46%), Gaps = 24/202 (11%)

Query: 554  KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK-------------YVE 600
            ++  Q++ +  +++EL+  KE  Q    +L+E++++ S+  EEK             Y E
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 601  ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
              +   RL  + Q++   +  + ++LE ++  G+   A      + ++ + E +   +  
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 661  KHIPESKLTSLAAALDENKDGKVNIDD----LVKVIELVDKEDVHISTSQVAEIVATLEK 716
            +   + +  +  A + + +D  + +DD    L K  +L+++    ++T+         E+
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-------LAEE 1018

Query: 717  EEKVEEKEKAKEKAEKEVAEVK 738
            EEK +   K K K E  ++E++
Sbjct: 1019 EEKAKNLTKLKNKHESMISELE 1040



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 25/290 (8%)

Query: 464  AKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS- 522
            ++LE  L++E   +QE  EK  +K    A DF  +      Q    + Q    +  LQ+ 
Sbjct: 1037 SELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 523  -----ETLKDTAPVLEGLKEEE----ITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
                 + +      L+ ++E E      +E++D    A +K ++QK+ L +E E L+   
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 574  EDVQDYSEDLQEI--KKELSKTGEEKYV-EESKASKRLTKRVQQMIGQ-IDGLISQLEMD 629
            ED  D +   QE+  K+E   T  +K + EE+++ +   + ++Q   Q ++ L  QLE  
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 630  QQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLV 689
            ++A      N     +    +A  +  + Q K   E K   L A + E    K +  +  
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE-LQSKCSDGERA 1274

Query: 690  KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
            +  EL DK  VH   ++V  +   L       E E    K  K+VA + S
Sbjct: 1275 RA-ELNDK--VHKLQNEVESVTGML------NEAEGKAIKLAKDVASLSS 1315



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 100/522 (19%), Positives = 210/522 (40%), Gaps = 74/522 (14%)

Query: 246  KEERLKKELRVKLELAKF-LQDTIEEMALKN-------------KAAKGSATKDFSVFFQ 291
            K E+ K++L  +LE  K  L+DT++  A +              K A    T+      Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 292  KIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMR 351
            ++R+   +   E   +  +    +  LD   +         LE ++      LR     +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT--------LEKENADLAGELRVLGQAK 1247

Query: 352  LRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIP 411
                    KL A+       V+ELQ+ C + G RA     D++           L  E+ 
Sbjct: 1248 QEVEHKKKKLEAQ-------VQELQSKC-SDGERARAELNDKVH---------KLQNEVE 1290

Query: 412  TSLLILSRAMYLPDTLSP-ADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL 470
            +   +L+ A      L+     L S LQ   E++ +E + K+       V  K +    L
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL------NVSTKLR---QL 1341

Query: 471  QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAP 530
            +EE    Q+  ++E++ +  +      ER ++      ++ + ++ D     E L++   
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 531  VLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL-----------LKEDVQDY 579
              +  KE E   ++ +  + A  KL++ K  L +E ++L +           L++  + +
Sbjct: 1396 RFQ--KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453

Query: 580  SEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAP-- 637
             + L E K   SK  +E+   E++A ++ TK +       + L ++ E+++    L    
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513

Query: 638  ----ANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIE 693
                ++    G+NV  + +   A++      +++L  L   L   +D K+ ++  ++ ++
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573

Query: 694  LVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVA 735
               + D+     Q  E    L+++    E E   E+ ++ +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 84/398 (21%), Positives = 158/398 (39%), Gaps = 50/398 (12%)

Query: 236  LPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIR- 294
            L   FE      +   +E R +L+      +T  E   K +A   +A K      + +  
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 295  --ETGERPSNEEIMRFSKL------FEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRF 346
              ++  +   E I +  KL      F+ EL     +R ++ A  K  E ++      L  
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA----KSLEA 1687

Query: 347  QLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHL 406
             L      + A ++   +  ++   + E + A    G  AL   + RL  ++ Q L+  L
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAE-ELASSLSGRNALQDEKRRLEARIAQ-LEEEL 1745

Query: 407  HQEIPTSLLILSR-------AMYLPDTL----SPADQLKSTLQTLPEIVAKEAQVKVAEV 455
             +E      +  R       A  L + L    S A + +S  Q L E   KE + K+ E+
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRSKLHEM 1804

Query: 456  EGEQVDNK-----AKLEATL-QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509
            EG  V +K     A LEA + Q E  ++QE REK+   +S   KD + + ++        
Sbjct: 1805 EG-AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL------- 1856

Query: 510  EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL 569
                ++ D    +E  K+ A   +G    +  K +++   +   ++   ++ L +E +E 
Sbjct: 1857 ----QVEDERKMAEQYKEQAE--KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE- 1909

Query: 570  ELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKR 607
                E  +    ++  +K +L +  E  +V   ++  R
Sbjct: 1910 --ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1945


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 109/526 (20%), Positives = 216/526 (41%), Gaps = 72/526 (13%)

Query: 241  ETQSLKEERLKKELRVKLELAKF------LQDTI-EEMALKNKAAKGSAT---------- 283
            +TQ L +E  +++L V  +L +       LQD + EEM  K    +  +T          
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385

Query: 284  --KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTN 341
              +DF+   + + E G++   +EI   ++ +E++    +        L + L+   +  +
Sbjct: 1386 KLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 342  NFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKE---LQAACRARGMRALGVTEDRLRGQL 398
            N  +    +  +  K D  L  E+ + S    E    +A  R +  +AL +        L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-----AL 1499

Query: 399  KQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIV-AKEAQVKVAEVEG 457
            ++ L+     E    +L       + D +S  D +   +  L +   A E Q++  + + 
Sbjct: 1500 EEALEAKEELERTNKMLKAE----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 458  EQVDNKAKLEATLQEEAAIQQEHREKELQ---KRSEVAKDFEPERVVAAPQRPGTEPQPE 514
            E+++++  L+AT  E+A ++ E   + L+   +R   A+D + E      QR   E + E
Sbjct: 1556 EELEDE--LQAT--EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611

Query: 515  MPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
            + D   Q          LEG        +++++ +D+  K +E+     K+  +L+   +
Sbjct: 1612 LEDERKQRALAAAAKKKLEG------DLKDLELQADSAIKGREEA---IKQLRKLQAQMK 1662

Query: 575  DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK 634
            D Q   ED +  + E+  T +E      K +K L   + Q       L   L   ++A K
Sbjct: 1663 DFQRELEDARASRDEIFATAKEN----EKKAKSLEADLMQ-------LQEDLAAAERARK 1711

Query: 635  LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIEL 694
             A        E + S     NA++  K   E+++  L   L+E +     + D V+    
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--- 1768

Query: 695  VDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEVKS 739
                    +T Q  ++   L  E    +K E A+++ E++  E++S
Sbjct: 1769 --------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 116/517 (22%), Positives = 199/517 (38%), Gaps = 96/517 (18%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEI 305
            K   LKK   ++  ++   +D   E A +NKA                 E  +R   EE+
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKA-----------------EKQKRDLGEEL 1155

Query: 306  MRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE 365
                   ED  TLD+    Q        EL++       R Q    L+    ++    E 
Sbjct: 1156 EALKTELED--TLDSTATQQ--------ELRA------KREQEVTVLKKALDEETRSHEA 1199

Query: 366  GVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
             V  +  K  QA              + L  QL+Q+                 RA     
Sbjct: 1200 QVQEMRQKHAQAV-------------EELTEQLEQF----------------KRAK---- 1226

Query: 426  TLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKEL 485
              +  D+ K TL+     +A E +V + + + E    K KLEA +QE  +   +      
Sbjct: 1227 --ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283

Query: 486  QKRSEVAK-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT--- 541
            +   +V K   E E V         +      D    S  L+DT  +L+    +++    
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343

Query: 542  -----KEEIDILSDACSKLQEQKKSLTKEKEELEL----LKEDVQDYS---EDLQEIKKE 589
                 +EE + L D   +  E K++L +    L +     K+ +QD++   E L+E KK 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 590  LSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ-----AGKLAPANGM 641
              K  E   ++Y E++ A  +L K   ++  ++D L+  L+  +Q       K    + +
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 642  PTGENVIS--VAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKED 699
               E  IS   A+  +  +      E+K  SLA AL+E  + K  ++   K+++  + ED
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-AEMED 1522

Query: 700  VHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAE 736
            +  S   V + V  LEK ++  E +  + K + E  E
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 74/340 (21%), Positives = 143/340 (42%), Gaps = 49/340 (14%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
            E+ AKE +++  +   ++ +N+ K       +   ++   +++LQ  +E+  + E  RV 
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 502  AAPQRPGTE----------PQPEMPDTVLQSETLKDTAPVL---EGLKEEEITKEEIDI- 547
             A ++   E           + E     LQ+E  K    +L   E L+EEE  ++++ + 
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 548  ----------LSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG--- 594
                      L D    + +Q   L+KE++ LE    D+     + +E  K L+K     
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 595  -------EEKYVEESKASKRLTKRVQQMIG-------QIDGLISQL-EMDQQAGKLAPAN 639
                   E +  +E K+ + L K  +++ G       QI  L +Q+ E+  Q  K     
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099

Query: 640  GMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNID----DLVKVIELV 695
                      +A+  NA+K+++ + E  ++ L   LD  +  +   +    DL + +E +
Sbjct: 1100 QAALARLDDEIAQKNNALKKIREL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 696  --DKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
              + ED   ST+   E+ A  E+E  V +K   +E    E
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 54/225 (24%), Positives = 101/225 (44%), Gaps = 39/225 (17%)

Query: 536  KEEEI--TKEEIDILSDACSKLQEQKKSLTKEKEEL-ELLKEDVQDYSE----------- 581
            KE+E+  TKE      +   +L+++   LT+EK  L E L+ + + Y+E           
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 582  --DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK----- 634
              +L+EI  E+    E +  EE    ++L    ++M  Q+  L  QLE ++ A +     
Sbjct: 924  KQELEEILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 635  --LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVI 692
               A A      + ++ + +  N + + + + E +++ L   L E ++   N+  L    
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 693  ELVDKEDVHISTSQVAEIVATLEKEEKV-EEKEKAKEKAEKEVAE 736
            E           S ++E+   L+KEEK  +E EK K K E + ++
Sbjct: 1040 E-----------SMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 39/202 (19%), Positives = 94/202 (46%), Gaps = 24/202 (11%)

Query: 554  KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK-------------YVE 600
            ++  Q++ +  +++EL+  KE  Q    +L+E++++ S+  EEK             Y E
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 601  ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
              +   RL  + Q++   +  + ++LE ++  G+   A      + ++ + E +   +  
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 661  KHIPESKLTSLAAALDENKDGKVNIDD----LVKVIELVDKEDVHISTSQVAEIVATLEK 716
            +   + +  +  A + + +D  + +DD    L K  +L+++    ++T+         E+
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-------LAEE 1025

Query: 717  EEKVEEKEKAKEKAEKEVAEVK 738
            EEK +   K K K E  ++E++
Sbjct: 1026 EEKAKNLTKLKNKHESMISELE 1047



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 25/290 (8%)

Query: 464  AKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS- 522
            ++LE  L++E   +QE  EK  +K    A DF  +      Q    + Q    +  LQ+ 
Sbjct: 1044 SELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 523  -----ETLKDTAPVLEGLKEEE----ITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
                 + +      L+ ++E E      +E++D    A +K ++QK+ L +E E L+   
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 574  EDVQDYSEDLQEI--KKELSKTGEEKYV-EESKASKRLTKRVQQMIGQ-IDGLISQLEMD 629
            ED  D +   QE+  K+E   T  +K + EE+++ +   + ++Q   Q ++ L  QLE  
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 630  QQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLV 689
            ++A      N     +    +A  +  + Q K   E K   L A + E    K +  +  
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE-LQSKCSDGERA 1281

Query: 690  KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
            +  EL DK  VH   ++V  +   L       E E    K  K+VA + S
Sbjct: 1282 RA-ELNDK--VHKLQNEVESVTGML------NEAEGKAIKLAKDVASLSS 1322



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 100/522 (19%), Positives = 210/522 (40%), Gaps = 74/522 (14%)

Query: 246  KEERLKKELRVKLELAKF-LQDTIEEMALKN-------------KAAKGSATKDFSVFFQ 291
            K E+ K++L  +LE  K  L+DT++  A +              K A    T+      Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 292  KIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMR 351
            ++R+   +   E   +  +    +  LD   +         LE ++      LR     +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT--------LEKENADLAGELRVLGQAK 1254

Query: 352  LRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIP 411
                    KL A+       V+ELQ+ C + G RA     D++           L  E+ 
Sbjct: 1255 QEVEHKKKKLEAQ-------VQELQSKC-SDGERARAELNDKVH---------KLQNEVE 1297

Query: 412  TSLLILSRAMYLPDTLSP-ADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL 470
            +   +L+ A      L+     L S LQ   E++ +E + K+       V  K +    L
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL------NVSTKLR---QL 1348

Query: 471  QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAP 530
            +EE    Q+  ++E++ +  +      ER ++      ++ + ++ D     E L++   
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 531  VLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL-----------LKEDVQDY 579
              +  KE E   ++ +  + A  KL++ K  L +E ++L +           L++  + +
Sbjct: 1403 RFQ--KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460

Query: 580  SEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAP-- 637
             + L E K   SK  +E+   E++A ++ TK +       + L ++ E+++    L    
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520

Query: 638  ----ANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIE 693
                ++    G+NV  + +   A++      +++L  L   L   +D K+ ++  ++ ++
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580

Query: 694  LVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVA 735
               + D+     Q  E    L+++    E E   E+ ++ +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 84/398 (21%), Positives = 158/398 (39%), Gaps = 50/398 (12%)

Query: 236  LPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIR- 294
            L   FE      +   +E R +L+      +T  E   K +A   +A K      + +  
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 295  --ETGERPSNEEIMRFSKL------FEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRF 346
              ++  +   E I +  KL      F+ EL     +R ++ A  K  E ++      L  
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA----KSLEA 1694

Query: 347  QLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHL 406
             L      + A ++   +  ++   + E + A    G  AL   + RL  ++ Q L+  L
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAE-ELASSLSGRNALQDEKRRLEARIAQ-LEEEL 1752

Query: 407  HQEIPTSLLILSR-------AMYLPDTL----SPADQLKSTLQTLPEIVAKEAQVKVAEV 455
             +E      +  R       A  L + L    S A + +S  Q L E   KE + K+ E+
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRSKLHEM 1811

Query: 456  EGEQVDNK-----AKLEATL-QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509
            EG  V +K     A LEA + Q E  ++QE REK+   +S   KD + + ++        
Sbjct: 1812 EG-AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL------- 1863

Query: 510  EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL 569
                ++ D    +E  K+ A   +G    +  K +++   +   ++   ++ L +E +E 
Sbjct: 1864 ----QVEDERKMAEQYKEQAE--KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE- 1916

Query: 570  ELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKR 607
                E  +    ++  +K +L +  E  +V   ++  R
Sbjct: 1917 --ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1952


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 109/526 (20%), Positives = 216/526 (41%), Gaps = 72/526 (13%)

Query: 241  ETQSLKEERLKKELRVKLELAKF------LQDTI-EEMALKNKAAKGSAT---------- 283
            +TQ L +E  +++L V  +L +       LQD + EEM  K    +  +T          
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385

Query: 284  --KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTN 341
              +DF+   + + E G++   +EI   ++ +E++    +        L + L+   +  +
Sbjct: 1386 KLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 342  NFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKE---LQAACRARGMRALGVTEDRLRGQL 398
            N  +    +  +  K D  L  E+ + S    E    +A  R +  +AL +        L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-----AL 1499

Query: 399  KQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIV-AKEAQVKVAEVEG 457
            ++ L+     E    +L       + D +S  D +   +  L +   A E Q++  + + 
Sbjct: 1500 EEALEAKEELERTNKMLKAE----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555

Query: 458  EQVDNKAKLEATLQEEAAIQQEHREKELQ---KRSEVAKDFEPERVVAAPQRPGTEPQPE 514
            E+++++  L+AT  E+A ++ E   + L+   +R   A+D + E      QR   E + E
Sbjct: 1556 EELEDE--LQAT--EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611

Query: 515  MPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
            + D   Q          LEG        +++++ +D+  K +E+     K+  +L+   +
Sbjct: 1612 LEDERKQRALAAAAKKKLEG------DLKDLELQADSAIKGREEA---IKQLRKLQAQMK 1662

Query: 575  DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK 634
            D Q   ED +  + E+  T +E      K +K L   + Q       L   L   ++A K
Sbjct: 1663 DFQRELEDARASRDEIFATAKEN----EKKAKSLEADLMQ-------LQEDLAAAERARK 1711

Query: 635  LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIEL 694
             A        E + S     NA++  K   E+++  L   L+E +     + D V+    
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--- 1768

Query: 695  VDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEVKS 739
                    +T Q  ++   L  E    +K E A+++ E++  E++S
Sbjct: 1769 --------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 116/517 (22%), Positives = 199/517 (38%), Gaps = 96/517 (18%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEI 305
            K   LKK   ++  ++   +D   E A +NKA                 E  +R   EE+
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKA-----------------EKQKRDLGEEL 1155

Query: 306  MRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE 365
                   ED  TLD+    Q        EL++       R Q    L+    ++    E 
Sbjct: 1156 EALKTELED--TLDSTATQQ--------ELRA------KREQEVTVLKKALDEETRSHEA 1199

Query: 366  GVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
             V  +  K  QA              + L  QL+Q+                 RA     
Sbjct: 1200 QVQEMRQKHAQAV-------------EELTEQLEQF----------------KRAK---- 1226

Query: 426  TLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKEL 485
              +  D+ K TL+     +A E +V + + + E    K KLEA +QE  +   +      
Sbjct: 1227 --ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283

Query: 486  QKRSEVAK-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT--- 541
            +   +V K   E E V         +      D    S  L+DT  +L+    +++    
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1343

Query: 542  -----KEEIDILSDACSKLQEQKKSLTKEKEELEL----LKEDVQDYS---EDLQEIKKE 589
                 +EE + L D   +  E K++L +    L +     K+ +QD++   E L+E KK 
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403

Query: 590  LSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ-----AGKLAPANGM 641
              K  E   ++Y E++ A  +L K   ++  ++D L+  L+  +Q       K    + +
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463

Query: 642  PTGENVIS--VAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKED 699
               E  IS   A+  +  +      E+K  SLA AL+E  + K  ++   K+++  + ED
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-AEMED 1522

Query: 700  VHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAE 736
            +  S   V + V  LEK ++  E +  + K + E  E
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 74/340 (21%), Positives = 143/340 (42%), Gaps = 49/340 (14%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
            E+ AKE +++  +   ++ +N+ K       +   ++   +++LQ  +E+  + E  RV 
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 502  AAPQRPGTE----------PQPEMPDTVLQSETLKDTAPVL---EGLKEEEITKEEIDI- 547
             A ++   E           + E     LQ+E  K    +L   E L+EEE  ++++ + 
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 548  ----------LSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG--- 594
                      L D    + +Q   L+KE++ LE    D+     + +E  K L+K     
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 595  -------EEKYVEESKASKRLTKRVQQMIG-------QIDGLISQL-EMDQQAGKLAPAN 639
                   E +  +E K+ + L K  +++ G       QI  L +Q+ E+  Q  K     
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099

Query: 640  GMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNID----DLVKVIELV 695
                      +A+  NA+K+++ + E  ++ L   LD  +  +   +    DL + +E +
Sbjct: 1100 QAALARLDDEIAQKNNALKKIREL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 696  --DKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
              + ED   ST+   E+ A  E+E  V +K   +E    E
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 54/225 (24%), Positives = 101/225 (44%), Gaps = 39/225 (17%)

Query: 536  KEEEI--TKEEIDILSDACSKLQEQKKSLTKEKEEL-ELLKEDVQDYSE----------- 581
            KE+E+  TKE      +   +L+++   LT+EK  L E L+ + + Y+E           
Sbjct: 864  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 582  --DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK----- 634
              +L+EI  E+    E +  EE    ++L    ++M  Q+  L  QLE ++ A +     
Sbjct: 924  KQELEEILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 635  --LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVI 692
               A A      + ++ + +  N + + + + E +++ L   L E ++   N+  L    
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 693  ELVDKEDVHISTSQVAEIVATLEKEEKV-EEKEKAKEKAEKEVAE 736
            E           S ++E+   L+KEEK  +E EK K K E + ++
Sbjct: 1040 E-----------SMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 39/202 (19%), Positives = 94/202 (46%), Gaps = 24/202 (11%)

Query: 554  KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK-------------YVE 600
            ++  Q++ +  +++EL+  KE  Q    +L+E++++ S+  EEK             Y E
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 601  ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
              +   RL  + Q++   +  + ++LE ++  G+   A      + ++ + E +   +  
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 661  KHIPESKLTSLAAALDENKDGKVNIDD----LVKVIELVDKEDVHISTSQVAEIVATLEK 716
            +   + +  +  A + + +D  + +DD    L K  +L+++    ++T+         E+
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-------LAEE 1025

Query: 717  EEKVEEKEKAKEKAEKEVAEVK 738
            EEK +   K K K E  ++E++
Sbjct: 1026 EEKAKNLTKLKNKHESMISELE 1047



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 25/290 (8%)

Query: 464  AKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS- 522
            ++LE  L++E   +QE  EK  +K    A DF  +      Q    + Q    +  LQ+ 
Sbjct: 1044 SELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 523  -----ETLKDTAPVLEGLKEEE----ITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
                 + +      L+ ++E E      +E++D    A +K ++QK+ L +E E L+   
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 574  EDVQDYSEDLQEI--KKELSKTGEEKYV-EESKASKRLTKRVQQMIGQ-IDGLISQLEMD 629
            ED  D +   QE+  K+E   T  +K + EE+++ +   + ++Q   Q ++ L  QLE  
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 630  QQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLV 689
            ++A      N     +    +A  +  + Q K   E K   L A + E    K +  +  
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE-LQSKCSDGERA 1281

Query: 690  KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
            +  EL DK  VH   ++V  +   L       E E    K  K+VA + S
Sbjct: 1282 RA-ELNDK--VHKLQNEVESVTGML------NEAEGKAIKLAKDVASLSS 1322



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 100/522 (19%), Positives = 210/522 (40%), Gaps = 74/522 (14%)

Query: 246  KEERLKKELRVKLELAKF-LQDTIEEMALKN-------------KAAKGSATKDFSVFFQ 291
            K E+ K++L  +LE  K  L+DT++  A +              K A    T+      Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 292  KIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMR 351
            ++R+   +   E   +  +    +  LD   +         LE ++      LR     +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT--------LEKENADLAGELRVLGQAK 1254

Query: 352  LRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIP 411
                    KL A+       V+ELQ+ C + G RA     D++           L  E+ 
Sbjct: 1255 QEVEHKKKKLEAQ-------VQELQSKC-SDGERARAELNDKVH---------KLQNEVE 1297

Query: 412  TSLLILSRAMYLPDTLSP-ADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL 470
            +   +L+ A      L+     L S LQ   E++ +E + K+       V  K +    L
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL------NVSTKLR---QL 1348

Query: 471  QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAP 530
            +EE    Q+  ++E++ +  +      ER ++      ++ + ++ D     E L++   
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 531  VLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL-----------LKEDVQDY 579
              +  KE E   ++ +  + A  KL++ K  L +E ++L +           L++  + +
Sbjct: 1403 RFQ--KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460

Query: 580  SEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAP-- 637
             + L E K   SK  +E+   E++A ++ TK +       + L ++ E+++    L    
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520

Query: 638  ----ANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIE 693
                ++    G+NV  + +   A++      +++L  L   L   +D K+ ++  ++ ++
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580

Query: 694  LVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVA 735
               + D+     Q  E    L+++    E E   E+ ++ +A
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 82/360 (22%), Positives = 145/360 (40%), Gaps = 40/360 (11%)

Query: 236  LPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIR- 294
            L   FE      +   +E R +L+      +T  E   K +A   +A K      + +  
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 295  --ETGERPSNEEIMRFSKL------FEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRF 346
              ++  +   E I +  KL      F+ EL     +R ++ A  K  E ++      L  
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA----KSLEA 1694

Query: 347  QLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHL 406
             L      + A ++   +  ++   + E + A    G  AL   + RL  ++ Q L+  L
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAE-ELASSLSGRNALQDEKRRLEARIAQ-LEEEL 1752

Query: 407  HQEIPTSLLILSR-------AMYLPDTL----SPADQLKSTLQTLPEIVAKEAQVKVAEV 455
             +E      +  R       A  L + L    S A + +S  Q L E   KE + K+ E+
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRSKLHEM 1811

Query: 456  EGEQVDNK-----AKLEATL-QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509
            EG  V +K     A LEA + Q E  ++QE REK+   +S   KD + + ++        
Sbjct: 1812 EG-AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ-----V 1865

Query: 510  EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL 569
            E + +M +   + +  K  A V +  ++ E  +EE   ++    KLQ +    T+  E +
Sbjct: 1866 EDERKMAEQ-YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 109/526 (20%), Positives = 216/526 (41%), Gaps = 72/526 (13%)

Query: 241  ETQSLKEERLKKELRVKLELAKF------LQDTI-EEMALKNKAAKGSAT---------- 283
            +TQ L +E  +++L V  +L +       LQD + EEM  K    +  +T          
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378

Query: 284  --KDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTN 341
              +DF+   + + E G++   +EI   ++ +E++    +        L + L+   +  +
Sbjct: 1379 KLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 342  NFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKE---LQAACRARGMRALGVTEDRLRGQL 398
            N  +    +  +  K D  L  E+ + S    E    +A  R +  +AL +        L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR-----AL 1492

Query: 399  KQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIV-AKEAQVKVAEVEG 457
            ++ L+     E    +L       + D +S  D +   +  L +   A E Q++  + + 
Sbjct: 1493 EEALEAKEELERTNKMLKAE----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548

Query: 458  EQVDNKAKLEATLQEEAAIQQEHREKELQ---KRSEVAKDFEPERVVAAPQRPGTEPQPE 514
            E+++++  L+AT  E+A ++ E   + L+   +R   A+D + E      QR   E + E
Sbjct: 1549 EELEDE--LQAT--EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604

Query: 515  MPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574
            + D   Q          LEG        +++++ +D+  K +E+     K+  +L+   +
Sbjct: 1605 LEDERKQRALAAAAKKKLEG------DLKDLELQADSAIKGREEA---IKQLRKLQAQMK 1655

Query: 575  DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK 634
            D Q   ED +  + E+  T +E      K +K L   + Q       L   L   ++A K
Sbjct: 1656 DFQRELEDARASRDEIFATAKEN----EKKAKSLEADLMQ-------LQEDLAAAERARK 1704

Query: 635  LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIEL 694
             A        E + S     NA++  K   E+++  L   L+E +     + D V+    
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--- 1761

Query: 695  VDKEDVHISTSQVAEIVATLEKEEKVEEK-EKAKEKAEKEVAEVKS 739
                    +T Q  ++   L  E    +K E A+++ E++  E++S
Sbjct: 1762 --------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 116/517 (22%), Positives = 199/517 (38%), Gaps = 96/517 (18%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEI 305
            K   LKK   ++  ++   +D   E A +NKA                 E  +R   EE+
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKA-----------------EKQKRDLGEEL 1148

Query: 306  MRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE 365
                   ED  TLD+    Q        EL++       R Q    L+    ++    E 
Sbjct: 1149 EALKTELED--TLDSTATQQ--------ELRA------KREQEVTVLKKALDEETRSHEA 1192

Query: 366  GVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPD 425
             V  +  K  QA              + L  QL+Q+                 RA     
Sbjct: 1193 QVQEMRQKHAQAV-------------EELTEQLEQF----------------KRAK---- 1219

Query: 426  TLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKEL 485
              +  D+ K TL+     +A E +V + + + E    K KLEA +QE  +   +      
Sbjct: 1220 --ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276

Query: 486  QKRSEVAK-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT--- 541
            +   +V K   E E V         +      D    S  L+DT  +L+    +++    
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST 1336

Query: 542  -----KEEIDILSDACSKLQEQKKSLTKEKEELEL----LKEDVQDYS---EDLQEIKKE 589
                 +EE + L D   +  E K++L +    L +     K+ +QD++   E L+E KK 
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396

Query: 590  LSKTGE---EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ-----AGKLAPANGM 641
              K  E   ++Y E++ A  +L K   ++  ++D L+  L+  +Q       K    + +
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456

Query: 642  PTGENVIS--VAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKED 699
               E  IS   A+  +  +      E+K  SLA AL+E  + K  ++   K+++  + ED
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-AEMED 1515

Query: 700  VHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAE 736
            +  S   V + V  LEK ++  E +  + K + E  E
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 74/340 (21%), Positives = 143/340 (42%), Gaps = 49/340 (14%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
            E+ AKE +++  +   ++ +N+ K       +   ++   +++LQ  +E+  + E  RV 
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 502  AAPQRPGTE----------PQPEMPDTVLQSETLKDTAPVL---EGLKEEEITKEEIDI- 547
             A ++   E           + E     LQ+E  K    +L   E L+EEE  ++++ + 
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 548  ----------LSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG--- 594
                      L D    + +Q   L+KE++ LE    D+     + +E  K L+K     
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 595  -------EEKYVEESKASKRLTKRVQQMIG-------QIDGLISQL-EMDQQAGKLAPAN 639
                   E +  +E K+ + L K  +++ G       QI  L +Q+ E+  Q  K     
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092

Query: 640  GMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNID----DLVKVIELV 695
                      +A+  NA+K+++ + E  ++ L   LD  +  +   +    DL + +E +
Sbjct: 1093 QAALARLDDEIAQKNNALKKIREL-EGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 696  --DKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
              + ED   ST+   E+ A  E+E  V +K   +E    E
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 54/225 (24%), Positives = 101/225 (44%), Gaps = 39/225 (17%)

Query: 536  KEEEI--TKEEIDILSDACSKLQEQKKSLTKEKEEL-ELLKEDVQDYSE----------- 581
            KE+E+  TKE      +   +L+++   LT+EK  L E L+ + + Y+E           
Sbjct: 857  KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 582  --DLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGK----- 634
              +L+EI  E+    E +  EE    ++L    ++M  Q+  L  QLE ++ A +     
Sbjct: 917  KQELEEILHEM----EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 635  --LAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVI 692
               A A      + ++ + +  N + + + + E +++ L   L E ++   N+  L    
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 693  ELVDKEDVHISTSQVAEIVATLEKEEKV-EEKEKAKEKAEKEVAE 736
            E           S ++E+   L+KEEK  +E EK K K E + ++
Sbjct: 1033 E-----------SMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 39/202 (19%), Positives = 94/202 (46%), Gaps = 24/202 (11%)

Query: 554  KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK-------------YVE 600
            ++  Q++ +  +++EL+  KE  Q    +L+E++++ S+  EEK             Y E
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 601  ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
              +   RL  + Q++   +  + ++LE ++  G+   A      + ++ + E +   +  
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 661  KHIPESKLTSLAAALDENKDGKVNIDD----LVKVIELVDKEDVHISTSQVAEIVATLEK 716
            +   + +  +  A + + +D  + +DD    L K  +L+++    ++T+         E+
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-------LAEE 1018

Query: 717  EEKVEEKEKAKEKAEKEVAEVK 738
            EEK +   K K K E  ++E++
Sbjct: 1019 EEKAKNLTKLKNKHESMISELE 1040



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 25/290 (8%)

Query: 464  AKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS- 522
            ++LE  L++E   +QE  EK  +K    A DF  +      Q    + Q    +  LQ+ 
Sbjct: 1037 SELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 523  -----ETLKDTAPVLEGLKEEE----ITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
                 + +      L+ ++E E      +E++D    A +K ++QK+ L +E E L+   
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 574  EDVQDYSEDLQEI--KKELSKTGEEKYV-EESKASKRLTKRVQQMIGQ-IDGLISQLEMD 629
            ED  D +   QE+  K+E   T  +K + EE+++ +   + ++Q   Q ++ L  QLE  
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 630  QQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLV 689
            ++A      N     +    +A  +  + Q K   E K   L A + E    K +  +  
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE-LQSKCSDGERA 1274

Query: 690  KVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
            +  EL DK  VH   ++V  +   L       E E    K  K+VA + S
Sbjct: 1275 RA-ELNDK--VHKLQNEVESVTGML------NEAEGKAIKLAKDVASLSS 1315



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 100/522 (19%), Positives = 210/522 (40%), Gaps = 74/522 (14%)

Query: 246  KEERLKKELRVKLELAKF-LQDTIEEMALKN-------------KAAKGSATKDFSVFFQ 291
            K E+ K++L  +LE  K  L+DT++  A +              K A    T+      Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 292  KIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMR 351
            ++R+   +   E   +  +    +  LD   +         LE ++      LR     +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT--------LEKENADLAGELRVLGQAK 1247

Query: 352  LRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIP 411
                    KL A+       V+ELQ+ C + G RA     D++           L  E+ 
Sbjct: 1248 QEVEHKKKKLEAQ-------VQELQSKC-SDGERARAELNDKVH---------KLQNEVE 1290

Query: 412  TSLLILSRAMYLPDTLSP-ADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATL 470
            +   +L+ A      L+     L S LQ   E++ +E + K+       V  K +    L
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL------NVSTKLR---QL 1341

Query: 471  QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAP 530
            +EE    Q+  ++E++ +  +      ER ++      ++ + ++ D     E L++   
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNL------ERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 531  VLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELEL-----------LKEDVQDY 579
              +  KE E   ++ +  + A  KL++ K  L +E ++L +           L++  + +
Sbjct: 1396 RFQ--KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453

Query: 580  SEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAP-- 637
             + L E K   SK  +E+   E++A ++ TK +       + L ++ E+++    L    
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513

Query: 638  ----ANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIE 693
                ++    G+NV  + +   A++      +++L  L   L   +D K+ ++  ++ ++
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573

Query: 694  LVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVA 735
               + D+     Q  E    L+++    E E   E+ ++ +A
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 82/360 (22%), Positives = 145/360 (40%), Gaps = 40/360 (11%)

Query: 236  LPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIR- 294
            L   FE      +   +E R +L+      +T  E   K +A   +A K      + +  
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 295  --ETGERPSNEEIMRFSKL------FEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRF 346
              ++  +   E I +  KL      F+ EL     +R ++ A  K  E ++      L  
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA----KSLEA 1687

Query: 347  QLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHL 406
             L      + A ++   +  ++   + E + A    G  AL   + RL  ++ Q L+  L
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAE-ELASSLSGRNALQDEKRRLEARIAQ-LEEEL 1745

Query: 407  HQEIPTSLLILSR-------AMYLPDTL----SPADQLKSTLQTLPEIVAKEAQVKVAEV 455
             +E      +  R       A  L + L    S A + +S  Q L E   KE + K+ E+
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQNKELRSKLHEM 1804

Query: 456  EGEQVDNK-----AKLEATL-QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509
            EG  V +K     A LEA + Q E  ++QE REK+   +S   KD + + ++        
Sbjct: 1805 EG-AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ-----V 1858

Query: 510  EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEEL 569
            E + +M +   + +  K  A V +  ++ E  +EE   ++    KLQ +    T+  E +
Sbjct: 1859 EDERKMAEQ-YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/307 (21%), Positives = 144/307 (46%), Gaps = 17/307 (5%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEV 491
           +L+   Q L E   KE Q ++A++E  + + K   E   QE+   +Q   EK+L+K+ E+
Sbjct: 364 ELEKRRQALLEQQRKE-QERLAQLERAEQERK---ERERQEQERKRQLELEKQLEKQREL 419

Query: 492 AKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDA 551
            +  E ER     +R   + + E    +      +      E L +    +E+I +L   
Sbjct: 420 ERQREEERRKEIERREAAKRELERQRQLEWERNRRQ-----ELLNQRNKEQEDIVVLKAK 474

Query: 552 CSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKR 611
              L+ + ++L  +K +LE   +D++      ++  +  +K+ E +  E +   ++L + 
Sbjct: 475 KKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQES 534

Query: 612 VQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSL 671
            QQM+G+   LI + ++     K    N +   ++++++   + A +  +     +L  +
Sbjct: 535 -QQMLGR---LIPEKQILNDQLKQVQQNSLHR-DSLVTLKRALEAKELARQHLRDQLDEV 589

Query: 672 AAALDENKDGKVNI--DDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEK 729
                 +K  +++I  + L ++ E+ +K+ +    S  AE +   E+E K+ E EK KE+
Sbjct: 590 EKET-RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEE 648

Query: 730 AEKEVAE 736
           A++   E
Sbjct: 649 AQRRAQE 655



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 69/330 (20%), Positives = 139/330 (42%), Gaps = 35/330 (10%)

Query: 431 DQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQ---QEHREKELQK 487
           +Q +   + L ++   E + K  E + ++   + +LE  L+++  ++   +E R KE+++
Sbjct: 374 EQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIER 433

Query: 488 RSEVAKDFEPERVVAAPQRPGTE----PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKE 543
           R    ++ E +R +   +    E       E  D V+     K     LE L +++   E
Sbjct: 434 REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLE 493

Query: 544 EIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESK 603
               L D   +L  Q++ +    +  EL   ++    + LQE ++ L +   EK +   +
Sbjct: 494 --GKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551

Query: 604 ASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPAN--------GMPTGENVISVAELIN 655
                 K+VQQ     D L++ L+   +A +LA  +           T   +  +    N
Sbjct: 552 L-----KQVQQNSLHRDSLVT-LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNN 605

Query: 656 AMKQVKHIPES----KLTSLAAALDENKDGKVNIDDLVKVIELV-------DKEDV-HIS 703
            +K+++ I       K  S+ A   + K+ +  I +L K  E         DK+ + H+ 
Sbjct: 606 QLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ 665

Query: 704 TSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
                +    L +EEK++ +E  K+K  +E
Sbjct: 666 QEDEHQRPRKLHEEEKLKREESVKKKDGEE 695



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 81/339 (23%), Positives = 140/339 (41%), Gaps = 40/339 (11%)

Query: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRET---G 297
           E +  ++  L+K+L  + EL +  ++   +   + +AAK    +   + +++ R      
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLN 459

Query: 298 ERPSNEE----IMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLR 353
           +R   +E    +    K  E EL   N  + QL       +LQ I      R +LT + +
Sbjct: 460 QRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEG-----KLQDI------RCRLTTQRQ 508

Query: 354 SIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTS 413
            I++ +K   E  +  +   + Q     + +  L   +  L  QLKQ     LH++   S
Sbjct: 509 EIESTNKS-RELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRD---S 564

Query: 414 LLILSRAM--------YLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAK 465
           L+ L RA+        +L D L   +  K T   L EI     Q+K    E  ++ NK +
Sbjct: 565 LVTLKRALEAKELARQHLRDQLDEVE--KETRSKLQEIDIFNNQLK----ELREIHNKQQ 618

Query: 466 LEATLQEEAAI----QQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ 521
           L+     EA      +QE +  EL+K+ E A+    ER     +    E + + P  + +
Sbjct: 619 LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHE 678

Query: 522 SETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKK 560
            E LK    V +   EE+  +E  D L     + QE  K
Sbjct: 679 EEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 67/307 (21%), Positives = 144/307 (46%), Gaps = 17/307 (5%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEV 491
           +L+   Q L E   KE Q ++A++E  + + K   E   QE+   +Q   EK+L+K+ E+
Sbjct: 364 ELEKRRQALLEQQRKE-QERLAQLERAEQERK---ERERQEQERKRQLELEKQLEKQREL 419

Query: 492 AKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDA 551
            +  E ER     +R   + + E    +      +      E L +    +E+I +L   
Sbjct: 420 ERQREEERRKEIERREAAKRELERQRQLEWERNRRQ-----ELLNQRNKEQEDIVVLKAK 474

Query: 552 CSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKR 611
              L+ + ++L  +K +LE   +D++      ++  +  +K+ E +  E +   ++L + 
Sbjct: 475 KKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQES 534

Query: 612 VQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSL 671
            QQM+G+   LI + ++     K    N +   ++++++   + A +  +     +L  +
Sbjct: 535 -QQMLGR---LIPEKQILNDQLKQVQQNSLHR-DSLVTLKRALEAKELARQHLRDQLDEV 589

Query: 672 AAALDENKDGKVNI--DDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEK 729
                 +K  +++I  + L ++ E+ +K+ +    S  AE +   E+E K+ E EK KE+
Sbjct: 590 EKET-RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEE 648

Query: 730 AEKEVAE 736
           A++   E
Sbjct: 649 AQRRAQE 655



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 69/330 (20%), Positives = 139/330 (42%), Gaps = 35/330 (10%)

Query: 431 DQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQ---QEHREKELQK 487
           +Q +   + L ++   E + K  E + ++   + +LE  L+++  ++   +E R KE+++
Sbjct: 374 EQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIER 433

Query: 488 RSEVAKDFEPERVVAAPQRPGTE----PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKE 543
           R    ++ E +R +   +    E       E  D V+     K     LE L +++   E
Sbjct: 434 REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLE 493

Query: 544 EIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESK 603
               L D   +L  Q++ +    +  EL   ++    + LQE ++ L +   EK +   +
Sbjct: 494 --GKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551

Query: 604 ASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPAN--------GMPTGENVISVAELIN 655
                 K+VQQ     D L++ L+   +A +LA  +           T   +  +    N
Sbjct: 552 L-----KQVQQNSLHRDSLVT-LKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNN 605

Query: 656 AMKQVKHIPES----KLTSLAAALDENKDGKVNIDDLVKVIELV-------DKEDV-HIS 703
            +K+++ I       K  S+ A   + K+ +  I +L K  E         DK+ + H+ 
Sbjct: 606 QLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ 665

Query: 704 TSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
                +    L +EEK++ +E  K+K  +E
Sbjct: 666 QEDEHQRPRKLHEEEKLKREESVKKKDGEE 695



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 81/339 (23%), Positives = 140/339 (41%), Gaps = 40/339 (11%)

Query: 241 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRET---G 297
           E +  ++  L+K+L  + EL +  ++   +   + +AAK    +   + +++ R      
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLN 459

Query: 298 ERPSNEE----IMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLR 353
           +R   +E    +    K  E EL   N  + QL       +LQ I      R +LT + +
Sbjct: 460 QRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEG-----KLQDI------RCRLTTQRQ 508

Query: 354 SIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTS 413
            I++ +K   E  +  +   + Q     + +  L   +  L  QLKQ     LH++   S
Sbjct: 509 EIESTNKS-RELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRD---S 564

Query: 414 LLILSRAM--------YLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAK 465
           L+ L RA+        +L D L   +  K T   L EI     Q+K    E  ++ NK +
Sbjct: 565 LVTLKRALEAKELARQHLRDQLDEVE--KETRSKLQEIDIFNNQLK----ELREIHNKQQ 618

Query: 466 LEATLQEEAAI----QQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ 521
           L+     EA      +QE +  EL+K+ E A+    ER     +    E + + P  + +
Sbjct: 619 LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHE 678

Query: 522 SETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKK 560
            E LK    V +   EE+  +E  D L     + QE  K
Sbjct: 679 EEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717


>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
          Length = 976

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 74/320 (23%), Positives = 137/320 (42%), Gaps = 34/320 (10%)

Query: 442 EIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVV 501
           E+  +E +  + E E    +NK + E   +E    +QE     LQ R +   D E +   
Sbjct: 430 EVELEELKKVLGEKETLLYENK-QFEKIAEELKGTEQELIGL-LQAREKEVHDLEIQLTA 487

Query: 502 AAPQRPGTEPQPEMPDTVLQSETLKDTAPVLE----GLKEEEITKEEIDILSDACSKLQE 557
                     + +   T L++E LK+T          L+ +E+T+E     SD   +L+ 
Sbjct: 488 ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQET----SDMTLELKN 543

Query: 558 QKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQ--- 614
           Q++ +   K++ E + + +++  E   +++ EL    EE   +  +   +L K  +    
Sbjct: 544 QQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNN 603

Query: 615 MIGQIDGLISQLEMDQQAGKLAPANGMPTGE--NVISVA------ELINAMKQVKHIP-- 664
           +  Q++     +E  QQ  K     G    +  NV  +       EL +A ++   I   
Sbjct: 604 LRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDT 663

Query: 665 -----ESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEK 719
                E K  S    L+E +  KV  D+ VK+ + +DK   H    ++AE+VA +EK + 
Sbjct: 664 YQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQH----KIAEMVALMEKHK- 718

Query: 720 VEEKEKAKEKAEKEVAEVKS 739
             + +K  E+ + E+   KS
Sbjct: 719 -HQYDKIIEERDSELGLYKS 737



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 76/340 (22%), Positives = 154/340 (45%), Gaps = 51/340 (15%)

Query: 442 EIVAKEAQVKVAEVEGEQVDNKAK-----LEAT------LQEEAAIQQEHREKELQKRSE 490
           EI  KE QV +  ++  + +NK K     LE +      L+E+  +Q E+ ++ ++K+  
Sbjct: 260 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHH 319

Query: 491 VAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEE----------I 540
           + K+ E  +V  + QR  +  +    D  + ++T+       E   EE           +
Sbjct: 320 LTKELEDIKV--SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377

Query: 541 TKEEIDILS---------DACSKLQEQKKSLT----KEKEELELLKEDVQDYSEDLQEIK 587
           T+ E  + S             K ++Q K LT    K+  ELE + +   +   +L+E+K
Sbjct: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437

Query: 588 KELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENV 647
           K L +  +E  + E+K  +++ + ++    ++ GL+   E +    ++     + T E  
Sbjct: 438 KVLGE--KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI-QLTAITTSEQY 494

Query: 648 IS--VAELINAMKQVKHIPESKLTSLAAALD-ENKDGKVNIDDLVKVIELVD-KEDVHIS 703
            S  V +L   ++  K +  ++LTS    L  ENK+      D+   +EL + +ED++ +
Sbjct: 495 YSKEVKDLKTELENEK-LKNTELTSHCNKLSLENKELTQETSDM--TLELKNQQEDINNN 551

Query: 704 TSQVAEIVATLEKEEKVE-----EKEKAKEKAEKEVAEVK 738
             Q   ++  +E  ++ E     E E  +E+ +++  EVK
Sbjct: 552 KKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVK 591



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 65/307 (21%), Positives = 131/307 (42%), Gaps = 59/307 (19%)

Query: 456 EGEQVDN-KAKLEATL-QEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQP 513
           E E++   K   EA L Q+E+ +Q+  +  E Q+++     F  E+V             
Sbjct: 112 EAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL----------- 160

Query: 514 EMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
           ++ + + +++ L         +KE   T+   ++L + C++  E+ K    E+EE   + 
Sbjct: 161 KLEEGIQENKDL---------IKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVY 211

Query: 574 EDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAG 633
            D+ +  E +    +EL    E   +E     K   +++Q +  +    I+  + ++Q  
Sbjct: 212 MDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN--DKEKQVS 269

Query: 634 KLAPANGMPTGENVISVAELINAMKQVKHIPE------------SKLTS--LAAALD--- 676
            L           +I + E  N MK +  + E            +KL S  L  +++   
Sbjct: 270 LL-----------LIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH 318

Query: 677 ----ENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEK 732
               E +D KV++   V   + ++ ED+ I+T  + ++  T EKE ++EE  KA+     
Sbjct: 319 HLTKELEDIKVSLQRSVSTQKALE-EDLQIATKTICQL--TEEKETQMEESNKARAAHSF 375

Query: 733 EVAEVKS 739
            V E ++
Sbjct: 376 VVTEFET 382


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 119/553 (21%), Positives = 239/553 (43%), Gaps = 72/553 (13%)

Query: 239  TFETQSLKEE--RLKKELR-VKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRE 295
            T + + L++E   LKK++  ++L LAK  +   E+ A +NK    + T++ S   + I +
Sbjct: 938  TAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVK--NLTEELSGLDETIAK 992

Query: 296  -TGERPSNEEIMRFS----KLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTM 350
             T E+ + +E  + +    +  ED++   N T+ +L    + LE  S+     LR  L  
Sbjct: 993  LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE-SSLEQEKKLRVDLER 1051

Query: 351  RLRSIKADDKLIAEEGVDSLNVKE-------------LQAACRARGMRALGVTEDRLRGQ 397
              R ++ D KL  E  +D  N K+              Q   +    + LG+   +   +
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111

Query: 398  LKQWLDLHLHQEIPTSLLILSRA-MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVE 456
            L+  ++  L +EI       ++      D     ++L   L+    + + + ++     E
Sbjct: 1112 LQARIE-ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR-E 1169

Query: 457  GEQVDNKAKLE-ATLQEEAAIQQEHREKELQKRSEVAKDFEP-ERVVAAPQRPGTEPQPE 514
             E +  +  LE ATLQ EA +    R+K     +E+ +  +  +RV    ++  +E + E
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAAL-RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1228

Query: 515  MPDTVLQSETLKDTAPVLEGL-------------KEEEITKEEIDILSDACSKLQEQKKS 561
            + D     E++  +   LE +             K EEI +  +  L+   S+LQ +   
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRS-LSELTTQKSRLQTEAGE 1287

Query: 562  LTKEKEELEL----LKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIG 617
            L+++ EE E     L    Q +++  +E+K++L         EE+KA   L   +Q    
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE--------EENKAKNALAHALQSSRH 1339

Query: 618  QIDGLISQLEMDQQAGKLAPANGMPTGENVISVAEL---INAMKQVKHIPESKLTSLAAA 674
              D L  Q E ++Q GK      +    + ++        +A+++ + + E+K   LA  
Sbjct: 1340 DCDLLREQYE-EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK-KKLAQR 1397

Query: 675  LDENKDGKVNIDDLVKVIELVDK------EDVHISTSQVAEIVATLEKEEKVEEKEKA-- 726
            L ++++    ++     +E   +      ED+ +   +   + A L+K+++  +K  A  
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457

Query: 727  KEKAEKEVAEVKS 739
            K K E+  AE+++
Sbjct: 1458 KTKCEESQAELEA 1470



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 80/355 (22%), Positives = 151/355 (42%), Gaps = 41/355 (11%)

Query: 423  LPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQ-VDNKAKLEATLQE--EAAIQQE 479
            L + L    Q K+ LQ   ++ A+   +  AE   +Q +  K +LEA ++E  E A  +E
Sbjct: 874  LEEKLVTLVQEKNDLQL--QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEE 931

Query: 480  HREKELQKR--------SEVAKDFEP-ERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAP 530
                EL  +        SE+ KD +  E  +A  ++     + ++ +   +   L +T  
Sbjct: 932  EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA 991

Query: 531  VLEGLKE--EEITKEEIDILS---DACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQE 585
             L   K+  +E  ++ +D L    D  + L + K  L ++ E+LE   E  +    DL+ 
Sbjct: 992  KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051

Query: 586  IKKELS---KTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMP 642
             K++L    K  +E  ++     ++L +R+++   +   L S++E +Q  G         
Sbjct: 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111

Query: 643  TGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKV-IELVDKE--- 698
                +  + E I A +  +   E + +  A  L+E  +       +    IEL  K    
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 1171

Query: 699  ------DVHISTSQVAEIVATLEKE---------EKVEEKEKAKEKAEKEVAEVK 738
                  D+  +T Q   +VA L K+         E+++  ++ K+K EKE +E K
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/308 (21%), Positives = 138/308 (44%), Gaps = 28/308 (9%)

Query: 434  KSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHR---EKELQKRSE 490
            +   +TL  + + + Q+K  ++    +D+  + +  L+E+ AI +      + E+++   
Sbjct: 1635 RQAAETLKHLRSVQGQLKDTQLH---LDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691

Query: 491  VAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSD 550
              +  E  R +A  +   +  + ++  T  Q+ +L  T   LE     ++  E  D   D
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHT--QNTSLIHTKKKLE-TDLMQLQSEVEDASRD 1748

Query: 551  ACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTK 610
            A +  ++ KK++T      E LK++ QD S  L+ +KK L +T ++      +A +   K
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1807

Query: 611  RVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTS 670
              ++ I +++  I +LE + +  +          +N  SV  L    ++VK         
Sbjct: 1808 GGKKQIQKLETRIRELEFELEGEQ---------KKNTESVKGLRKYERRVK--------E 1850

Query: 671  LAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVE-EKEKAKEK 729
            L    +E++   + + DLV  +++  K     +     +  A L K  K + E E+A+E+
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910

Query: 730  AEKEVAEV 737
            A+   ++V
Sbjct: 1911 ADIAESQV 1918



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 113/538 (21%), Positives = 211/538 (39%), Gaps = 85/538 (15%)

Query: 230  KLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVF 289
            KL  + L S+ E+ S  +  L+K       + + L+D + E   KN+  + S ++  +  
Sbjct: 1226 KLEIDDLSSSMESVSKSKANLEK-------ICRTLEDQLSEARGKNEEIQRSLSELTTQK 1278

Query: 290  FQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQ-SIGTNNFLRFQL 348
             +   E GE     E        E E  +  L+R +     +  EL+  +   N  +  L
Sbjct: 1279 SRLQTEAGELSRQLE--------EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL 1330

Query: 349  TMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQ 408
               L+S + D  L+ E+        E +   +A   RAL     +   ++ QW       
Sbjct: 1331 AHALQSSRHDCDLLREQ-------YEEEQEGKAELQRALS----KANSEVAQW------- 1372

Query: 409  EIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNK-AKLE 467
                      R  Y  D +   ++L+   + L +      +++ +E + E V+ K A LE
Sbjct: 1373 ----------RTKYETDAIQRTEELEEAKKKLAQ------RLQDSEEQVEAVNAKCASLE 1416

Query: 468  ATLQ------EEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ 521
             T Q      E+  +  E          +  ++F+  +V+A  +    E Q E+  ++ +
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD--KVLAEWKTKCEESQAELEASLKE 1474

Query: 522  SETLKDTAPVLEGLKEE-----EITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDV 576
            S +L      L+   EE     E  K E   L    + L EQ     K   ELE  ++ +
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQI 1534

Query: 577  QDYSEDLQEIKKELSKTGEEKYVEESKASKRLTK---RVQQMIGQIDGLISQLEMDQQAG 633
            +    D+Q   +E     E +  +  +    LT+    + + I + D  I QL+ + Q  
Sbjct: 1535 ELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ-- 1592

Query: 634  KLAPANGMPTGENVISVAELINAMK-----------QVKHI---PESKLTSLAAALDENK 679
            +            V S  E I   K           Q+ H        L  L +   + K
Sbjct: 1593 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 1652

Query: 680  DGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEK-EEKVEEKEKAKEKAEKEVAE 736
            D ++++DD ++  E + KE + I   +   + A +E+    +E+ E+A++ AE+E+ +
Sbjct: 1653 DTQLHLDDALRGQEDL-KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 50/284 (17%), Positives = 133/284 (46%), Gaps = 36/284 (12%)

Query: 487  KRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEID 546
            K   + K  E E+ +A  +    + + E+  +  + + L++    L  ++E+   + ++ 
Sbjct: 836  KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTL--VQEKNDLQLQVQ 893

Query: 547  ILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELS----KTGEE------ 596
              S+     +E+   L K K +LE   ++V + +ED +EI  EL+    K  +E      
Sbjct: 894  AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 953

Query: 597  ----------KYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGEN 646
                      K  +E  A++   K + + +  +D  I++L  +++A + A    +   ++
Sbjct: 954  DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL---DD 1010

Query: 647  VISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIE---LVDKEDVHIS 703
            + +  + +N++ + K   E ++  L ++L++ K  +V+++   + +E    + +E +   
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDL 1070

Query: 704  TSQVAEIVATLEKEE--------KVEEKEKAKEKAEKEVAEVKS 739
             +   ++   L+K++        KVE+++    + +K++ E+++
Sbjct: 1071 ENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 72/335 (21%), Positives = 147/335 (43%), Gaps = 50/335 (14%)

Query: 443 IVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERV-- 500
           +  K+A+ K  E + ++ + KAKL    ++E   + E  +K+  K+ E  + FE E V  
Sbjct: 228 VAQKKAEKKERERK-KRDEEKAKLRKLKEKE---ELETGKKDQSKQKESQRKFEEETVKS 283

Query: 501 ---VAAPQRPGTEPQPEMPDTVL---QSETLKDTAPVLEGLKEEEI-------TKEEIDI 547
              V     P +E + E P       + +  K      +G KEE+        +K  +  
Sbjct: 284 KVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA 343

Query: 548 LSDACSKLQEQKKSLTKEKEE-------LELLKEDVQDYSEDLQEIKKELSKTGEEKYVE 600
           + +A +KL+E+++   +E+EE       LE  +++ +   ++ +E KK+  K  +E+  +
Sbjct: 344 MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKK 403

Query: 601 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV 660
           E K    LTK  ++   + +  +  L+   Q  ++   + +P    +    +     +Q+
Sbjct: 404 EGKL---LTKSQREARARAEATLKLLQA--QGVEVPSKDSLPKKRPIYEDKKRKKIPQQL 458

Query: 661 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV 720
           +    S+   L AA++  + G    ++    +E  ++ED   +     E +A+ E+ EKV
Sbjct: 459 ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKV 518

Query: 721 -------------------EEKEKAKEKAEKEVAE 736
                              EE+E+  E++E+E  E
Sbjct: 519 EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 71/325 (21%), Positives = 140/325 (43%), Gaps = 42/325 (12%)

Query: 454 EVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAP--QRPGTEP 511
           E   E  D   K++   Q++A  ++  R+K  ++++++ K  E E +      Q    E 
Sbjct: 213 ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKES 272

Query: 512 QPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELE- 570
           Q +  +  ++S+   DT  +    ++ E      D       K  ++KK   KE++E E 
Sbjct: 273 QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332

Query: 571 ------------------LLKEDVQDYSEDLQEIKK--EL-SKTGEEKYVEESK--ASKR 607
                             L +E+ +   E+ + IK+  EL +K  EE+ +E+ K    K+
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392

Query: 608 LTKRVQQMIGQIDGLISQLEMDQQAG-----KLAPANGMPT-GENVISVAELINAMKQVK 661
             K  ++ + +   L+++ + + +A      KL  A G+    ++ +     I   K+ K
Sbjct: 393 KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452

Query: 662 HIPE-------SKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATL 714
            IP+       S+   L AA++  + G    ++    +E  ++ED   +     E +A+ 
Sbjct: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512

Query: 715 EKEEKVEEKE---KAKEKAEKEVAE 736
           E+ EKVE  +   + KE  E+E  E
Sbjct: 513 EETEKVEGNKVHIEVKENPEEEEEE 537



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 47/252 (18%), Positives = 115/252 (45%), Gaps = 15/252 (5%)

Query: 434 KSTLQTLPEIVAK--EAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEV 491
           K+T++ + E +AK  E + +    E E++    +LEA  +EE  ++QE RE++ QK  E 
Sbjct: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER 397

Query: 492 AKDFEPERVVAAPQRPGTEPQPEMPDTVLQS--------ETLKDTAPVLEGLKEEEITKE 543
            +  + E  +    +     + E    +LQ+        ++L    P+ E  K ++I ++
Sbjct: 398 KERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQ 457

Query: 544 ----EIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEE-KY 598
               E+    + C+ ++  ++ + +++E    ++ + ++ +ED      E   + EE + 
Sbjct: 458 LESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEK 517

Query: 599 VEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMK 658
           VE +K    + +  ++   + +      E +++  +   + G    E    V++  ++ K
Sbjct: 518 VEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK 577

Query: 659 QVKHIPESKLTS 670
            +   P  +++S
Sbjct: 578 TLDKKPSKEMSS 589



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 20/61 (32%), Positives = 34/61 (55%), Gaps = 7/61 (11%)

Query: 536 KEEEITKEEIDILSDAC-------SKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKK 588
           K E+ TK++ID+ + A        +K QE +KS  K+K+E +    D  D  ++L+E+  
Sbjct: 8   KSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSL 67

Query: 589 E 589
           E
Sbjct: 68  E 68


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 70/317 (22%), Positives = 137/317 (43%), Gaps = 29/317 (9%)

Query: 431  DQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSE 490
            DQL S ++ L  +    AQVK  E+   + + + +L+    E          +++   S 
Sbjct: 747  DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLD---YESQTAHDNLLTEQIHSLSI 803

Query: 491  VAKDFEPERVVAAPQRPGTEPQPEMPDTV---LQSETLKDTAPVLEGLKEEEITKEEIDI 547
             AK  + +  V   +    + Q     T+   LQS+     + VLEG +       +++ 
Sbjct: 804  EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863

Query: 548  LSDACS----KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESK 603
            LS A S    ++ +  + L ++K ++E L++ +++  + + EI    S T +   + E K
Sbjct: 864  LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI--SFSMTEKMVQLNEEK 921

Query: 604  AS-----KRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPAN---GMPTGENVISVAELIN 655
             S     K L +++  +    +    Q+E D +       N     P G+  IS  EL +
Sbjct: 922  FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ--ISKEELQH 979

Query: 656  AMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE 715
                +K   E +   L AAL       +N  +L++ +  +++E  ++      EI  +  
Sbjct: 980  EFDLLKKENEQRKRKLQAAL-------INRKELLQRVSRLEEELANLKDESKKEIPLSET 1032

Query: 716  KEEKVEEKEKAKEKAEK 732
            +  +VEE ++ KE +EK
Sbjct: 1033 ERGEVEEDKENKEYSEK 1049



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 75/307 (24%), Positives = 134/307 (43%), Gaps = 37/307 (12%)

Query: 434  KSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAK 493
            K+TL  L +I  K+ ++K+ +   E+V     L   +QEE +     R  +L++ +E  K
Sbjct: 1870 KNTL--LSQISTKDGELKMLQ---EEVTKMNLLNQQIQEELS-----RVTKLKETAEEEK 1919

Query: 494  DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACS 553
            D   ER++                  L          V +   + E+ + E+  L    S
Sbjct: 1920 DDLEERLMNQLAE-------------LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966

Query: 554  KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEE-SKASKRLTKRV 612
            +L+E+K+ L KEK ++E   E  ++Y E +Q  +KE       K ++E  K  ++  K++
Sbjct: 1967 ELEEEKQQLVKEKTKVE--SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024

Query: 613  QQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLA 672
            Q+   +    IS LE   +A +          E  I+   L  A++  K   +++L S  
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLE--ITKENLAQAVEHRKK-AQAELASFK 2081

Query: 673  AALDENKD--GKVNIDDLVKVIEL-VDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEK 729
              LD+ +    +V  D+L    EL  +KE V     Q  E     + E ++E+ E+   K
Sbjct: 2082 VLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE-----DLERRLEQAEEKHLK 2136

Query: 730  AEKEVAE 736
             +K + E
Sbjct: 2137 EKKNMQE 2143



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 115/545 (21%), Positives = 240/545 (44%), Gaps = 82/545 (15%)

Query: 242  TQSLKEER--LKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGER 299
            +Q+L+ E+  L  ++  K    K LQ+ + +M L N+  +   ++       K++ET E 
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR-----VTKLKETAEE 1917

Query: 300  PSNE-EIMRFSKLFEDELTLDNLTRPQLVALCK--LLELQSIGTNNFLRFQLTMRLRSIK 356
              ++ E    ++L E   ++ N  +    A  K  LLE +       +      + + +K
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977

Query: 357  ADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWL-----DLHLHQEIP 411
               K+ +E   + L  +++Q A +  G ++       L  + +Q +     D   +QE  
Sbjct: 1978 EKTKVESEIRKEYL--EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI 2035

Query: 412  TSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVA--KEAQVKVAEVEGEQVDNKAKLEAT 469
            ++L    +A+    T S  D L+ T + L + V   K+AQ ++A  +    D +++    
Sbjct: 2036 SALERTVKALEFVQTESQKD-LEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094

Query: 470  LQEEAAIQQE-HREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTV--LQSET-- 524
            L +   +++E    KE  K     KD + ER +   +    + +  M + +  L+ E   
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154

Query: 525  LKDTAPVLE---GLKEEEI-----------------TKEEIDILSDACSKLQEQKK---- 560
            L++T   ++     K++E+                 TK    +  D    + E KK    
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214

Query: 561  ---SLTKEKEELEL-------LKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTK 610
               ++  ++EE+ L       LK+ ++  S  ++E+K  +S+   +K + ESKA   +  
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV-- 2272

Query: 611  RVQQMI-----GQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPE 665
            ++QQ +     G+   L+SQLE  +            + +N   +A+L + +K +K    
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHL--------YHSSQN--ELAKLESELKSLK---- 2318

Query: 666  SKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQV-AEIVATLEKEEKVEEKE 724
             +LT L+ +L++ K+ K N++ +++  E  D ++   S  Q+  ++ A+ E   ++ E+ 
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQE-ADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377

Query: 725  KAKEK 729
              KE+
Sbjct: 2378 NMKEQ 2382



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 80/421 (19%), Positives = 164/421 (38%), Gaps = 66/421 (15%)

Query: 368  DSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTL 427
            ++L+    Q A   + M +L    DR+  + K+W       E   S  I S+   +    
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW-------ERKFSDAIQSKEEEIRLKE 2230

Query: 428  SPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQV--DNKAKLEATLQEEAAIQQEHREKEL 485
                 LK  L+ +  I  +E ++ ++ +E ++   ++KA+ E  LQ++     +   KEL
Sbjct: 2231 DNCSVLKDQLRQM-SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289

Query: 486  QKRSEVAKDF--EPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKE 543
              + E  +      +  +A  +      + ++ D     E  K+    LEG+    I ++
Sbjct: 2290 LSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI----IRQQ 2345

Query: 544  EIDILSDACS------KLQEQKKSLTKEKEELELLKEDV-------------------QD 578
            E DI +   S       LQ  ++  ++  EE+ + ++ +                   Q 
Sbjct: 2346 EADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405

Query: 579  YSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQ-------------QMIGQIDGLISQ 625
            + ++++E++  LS+  EE  V E +  K + K  Q             Q   Q+D  +  
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465

Query: 626  LEMDQQAGKLAPANGMPTGENVISVA----ELINAMKQVKHIPESKLTSLAAALDENKDG 681
            +   Q        +     E  +S+     +LI       +  + ++  L + +D+    
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525

Query: 682  KVNID--------DLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
               +D        DL +VI + D +   +   Q+ +      K  K+EEK K  E+A ++
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585

Query: 734  V 734
            +
Sbjct: 2586 L 2586



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 115/588 (19%), Positives = 244/588 (41%), Gaps = 98/588 (16%)

Query: 222  EFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGS 281
            +F L V +K     L      +  K+E+++++     E++  L+   +EM+   + +K  
Sbjct: 921  KFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDN----EVSSGLKQNYDEMSPAGQISKEE 976

Query: 282  ATKDFSVFFQKIRETGERP-------SNEEIMRFSKLFEDELTLDNLTRPQL-VALCKLL 333
               +F +  +K  E  +R          E + R S+L E+   L + ++ ++ ++  +  
Sbjct: 977  LQHEFDLL-KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035

Query: 334  ELQSIGTNN-FLRFQLTMRLRSIKADDK-LIAEEGVDSLNVK---ELQAACRARGMRALG 388
            E++    N  +    +T + + I+   K  I+E+ V+  +++   E + A   +    + 
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVK 1095

Query: 389  VTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQL---KSTLQTLPEIVA 445
                 L+ +  Q +DL L  EI  +  I+ + +      S  D +   K T+   P    
Sbjct: 1096 QMNQTLQDKTNQ-IDL-LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153

Query: 446  K------EAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSE--------- 490
                   E + K+  +E E+   + KL+  L    AI ++ +EKE   R E         
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213

Query: 491  -VAKDFEPE------------------------RVVAAPQRPGTEPQPEMPDTVLQSETL 525
             + + F+ +                        ++ +  Q+      P + + + ++   
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273

Query: 526  KDTAPVLEG--LKEEEITKEEIDILSDACS--KLQEQKKSLTKEKEELEL----LKEDVQ 577
              T PVLE     +     E+   L    S  +++ Q K +  EK ELEL       ++ 
Sbjct: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT 1333

Query: 578  DYSEDLQEIKKELSKTGEE----KYV--EESKASKRLTKRVQQMIGQIDGLISQLEMDQQ 631
              SE++ +++++++K G E    K V  E    ++ L ++++    QI GL    E+  +
Sbjct: 1334 KKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPK 1393

Query: 632  AGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKV 691
              +L                +LI+  ++       +L+   AAL + +   +  +DL+K 
Sbjct: 1394 LDEL---------------QKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKA 1438

Query: 692  ----IELVDKE-DVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEV 734
                +E+  KE D  I   QV E+    +K E++ E+ +AK++ ++++
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQV-ELCEMKQKPEEIGEESRAKQQIQRKL 1485



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 49/202 (24%), Positives = 96/202 (47%), Gaps = 17/202 (8%)

Query: 554 KLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK------YVEESKASKR 607
           +L +  KS T+E+ E+E +K  +Q+  E +  ++ +L++   E+       +EE    K+
Sbjct: 131 QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 608 LTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENV-ISVAELINAMKQ--VKHIP 664
             +  ++ I  +   +SQ + +Q A ++           V +   EL+  + Q  V+   
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEM 250

Query: 665 ESKLTSLAAALDENKD---GKVNIDDLVKVIELVDKEDVHISTSQVAEIVA---TLEK-- 716
           + KL  L   L+E+++   G+  + DL++      ++   I + Q+ ++ A   TL    
Sbjct: 251 QQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTV 310

Query: 717 EEKVEEKEKAKEKAEKEVAEVK 738
           E + EE +   EK E EVAE K
Sbjct: 311 ETEREESKILLEKMELEVAERK 332



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 89/428 (20%), Positives = 172/428 (40%), Gaps = 80/428 (18%)

Query: 244  SLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNE 303
            ++K+ + K+ L V+L+  K          L+NK AK           +K++E+ E  +NE
Sbjct: 2545 TIKDSQQKQLLEVQLQQNK---------ELENKYAK---------LEEKLKESEE--ANE 2584

Query: 304  EIMR-FSKLFEDELTLDNLTRPQLVALCKLLE----LQSIGTNNFLRFQLTMRLRSIKAD 358
            ++ R F+ L E++  L        V++ +L      LQ  GT      QL ++   +   
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644

Query: 359  DKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILS 418
              L +        ++E     +    + +G  ED+L+ +LK     HLH +         
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK-----HLHHD--------- 2690

Query: 419  RAMYLPDTLSPADQLKSTLQTLPE------IVAKEAQVKVAEVE---------------- 456
              +   +T +  +++    + L E      +V KE +   A+++                
Sbjct: 2691 AGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA 2750

Query: 457  GEQVDN-KAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEM 515
             E++D  K K +A+L+E A +    +E+ L  R   A   E      A     TE     
Sbjct: 2751 NEELDELKRKYDASLKELAQL----KEQGLLNRERDALLSE-----TAFSMNSTEENSLS 2801

Query: 516  PDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKED 575
                L  + L     +L    + E +  ++   S A + LQ ++  L  E E+    +E 
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861

Query: 576  VQDYS-------EDLQEIKKELS--KTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQL 626
             Q  +        ++Q +KK +S  +   ++ ++E K  ++   ++ Q I ++  L +QL
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921

Query: 627  EMDQQAGK 634
            +  Q   K
Sbjct: 2922 QEYQDKTK 2929



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 75/351 (21%), Positives = 145/351 (41%), Gaps = 57/351 (16%)

Query: 243 QSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSN 302
           + ++ E++K +L+ K EL   LQ  + +   +  A   +  ++F +  Q+++E  E    
Sbjct: 142 EEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEE---- 197

Query: 303 EEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLI 362
                F    + +L+    T+ +  A       Q +      RF+  +RL   +   +L+
Sbjct: 198 -----FISTLQAQLSQ---TQAEQAA-------QQVVREKDARFETQVRLHEDELL-QLV 241

Query: 363 AEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMY 422
            +  V++    E+Q   R    R L   E+ L G+  Q +DL L QE+  +     R   
Sbjct: 242 TQADVET----EMQQKLRVL-QRKLEEHEESLVGRA-QVVDL-LQQELTAAE---QRNQI 291

Query: 423 LPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHRE 482
           L   L   +   +TL+   E   +E+++ + ++E E  + K      LQEE     E  E
Sbjct: 292 LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH-NLQEEMHHLLEQFE 350

Query: 483 KELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITK 542
           +  Q ++E+       R  A  Q+   E + +    +   +T ++               
Sbjct: 351 QAGQAQAELES-----RYSALEQKHKAEMEEKTSHILSLQKTGQE--------------- 390

Query: 543 EEIDILSDACSKLQEQKKSLTKEKEELELLK-EDVQDYSEDLQEIKKELSK 592
                L  AC  L++Q   L ++K E  +   + +Q   + LQ+  KE+S+
Sbjct: 391 -----LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 59/245 (24%), Positives = 106/245 (43%), Gaps = 36/245 (14%)

Query: 521  QSETLKDTAPVLEGLKEE--------EITKEEIDILSDACSKLQEQKK-----SLTKEKE 567
            + E +++   V  GLK+         +I+KEE+    D   K  EQ+K     +L   KE
Sbjct: 945  KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE 1004

Query: 568  ELELLKEDVQDYSEDLQEIKKELSKTGEEK-YVEESKASKR-----LTKRVQQMIGQIDG 621
             L+ +    ++ +    E KKE+  +  E+  VEE K +K      +T + Q++   +  
Sbjct: 1005 LLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQ 1064

Query: 622  LISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENK-- 679
             IS+ E++ Q  +      +   E   ++ + +N   Q K    +++  L A + EN+  
Sbjct: 1065 TISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDK---TNQIDLLQAEISENQAI 1121

Query: 680  -------DGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATL-EKEEKVEEKEKAKEKAE 731
                   +   +  D V ++    KE V IS            E EEK+   EK KE+ +
Sbjct: 1122 IQKLITSNTDASDGDSVALV----KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ 1177

Query: 732  KEVAE 736
            K++ E
Sbjct: 1178 KKLQE 1182



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 81/385 (21%), Positives = 161/385 (41%), Gaps = 86/385 (22%)

Query: 435  STLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKD 494
            S LQ    +   +AQ+K  E+E E+V+ + K+ +T  E     +E  + + Q   +   +
Sbjct: 1296 SALQGGTSVAQIKAQLK--EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ-GLE 1352

Query: 495  FEPERVVAAPQRPGTEP-QPEMPDTVLQS---ETLKDTAPVLEGLKEEEITKEEIDILSD 550
             E  + V+       E  Q ++  + LQ    E L++  P L+ L ++ I+K+E D+ S 
Sbjct: 1353 IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDEL-QKLISKKEEDV-SY 1410

Query: 551  ACSKLQEQKKSLTK------EKEEL-----ELLKEDVQDYSEDLQEIKKELS--KTGEEK 597
               +L E++ +LTK      E+E+L       L+   +++ E +++++ EL   K   E+
Sbjct: 1411 LSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470

Query: 598  YVEESKASKRLTKRVQQMI---------------------GQIDGLISQL---------- 626
              EES+A +++ +++Q  +                     G I+ L   L          
Sbjct: 1471 IGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ 1530

Query: 627  --EMDQQAGKLAPAN------------GMPTGENVISVAELINA------------MKQV 660
              E D   G+LA                +   +++ S  E +              +K++
Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI 1590

Query: 661  KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHIS------TSQVAEIVATL 714
            + +  SK+       +++K+ +   + L++  E V  E   I         +  E+   L
Sbjct: 1591 ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL 1650

Query: 715  EKEE-KVEEKEKAKEKAEKEVAEVK 738
               E   +E EK  ++AE+E+ E+K
Sbjct: 1651 RSTEANKKETEKQLQEAEQEMEEMK 1675



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 93/419 (22%), Positives = 161/419 (38%), Gaps = 55/419 (13%)

Query: 242  TQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSV------FFQKIRE 295
            TQS+  E  +++      L+   + T  E     K+A  + +KDFS       + Q+I +
Sbjct: 1790 TQSIPGETEEQD-----SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844

Query: 296  TGERPSN-EEIMRFSKLFEDELTLDNLTRPQLVAL----CKLLELQSIGTNNFLRFQLTM 350
              ER +  EE  + +K F   L  +  T    ++      K+L+ + +   N L  Q+  
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ-EEVTKMNLLNQQIQE 1903

Query: 351  RLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEI 410
             L  +    K  AEE  D L           R M  L      +    +   D  +  E 
Sbjct: 1904 ELSRV-TKLKETAEEEKDDLE---------ERLMNQLAELNGSIGNYCQDVTDAQIKNE- 1952

Query: 411  PTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAE-VEGEQVDNKAKLEAT 469
                L+ S    L   +S  ++ K  L      V  E + +  E ++G Q +   K  A 
Sbjct: 1953 ----LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008

Query: 470  LQEEAAIQQEHREKELQKRS--EVAKDFEPERVVAAPQRPGTEPQPEMPDT----VLQSE 523
              +E   +++   K+LQK       K    ER V A +   TE Q ++  T        E
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068

Query: 524  TLKDTAPVLEGLKE--EEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSE 581
              K     L   K   ++   E   +L+D     +E + +    K +++   ED++   E
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128

Query: 582  DLQEIKKELSKTGEEK---------YVEESKASKRLT-----KRVQQMIGQIDGLISQL 626
              +E   +  K  +EK         ++EE+    ++T     K VQQ+   +D  ++QL
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 101/505 (20%), Positives = 212/505 (41%), Gaps = 61/505 (12%)

Query: 245  LKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEE 304
            LK      EL  K E    LQ+ I +  L+ ++ K + + +  V  + +++  E  S  +
Sbjct: 1323 LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK-TVSHEAEVHAESLQQKLES-SQLQ 1380

Query: 305  IMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSI-KADDKLIA 363
            I     L E         +P+L  L KL+  +    + +L  QL+ +  ++ K   ++I 
Sbjct: 1381 IAGLEHLRE--------LQPKLDELQKLISKKEEDVS-YLSGQLSEKEAALTKIQTEIIE 1431

Query: 364  EEG-VDSLNVK-ELQAACRARGMRALGVTEDRLRGQLKQ-WLDLHLHQEIPTSL--LILS 418
            +E  + +L+ + E+QA      ++ L V    ++ + ++   +    Q+I   L   ++S
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491

Query: 419  RAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQ 478
            R   L +  S  ++L     T+  +    A V+       QV  + K + T+    A+ Q
Sbjct: 1492 RKEALKENKSLQEELSLARGTIERLTKSLADVE------SQVSAQNKEKDTVLGRLALLQ 1545

Query: 479  EHREK-------ELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTA-- 529
            E R+K        L +   ++   E  ++         E   +  +++  S+  + T   
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605

Query: 530  -PVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKK 588
                E  KE EI  +  + +S+   ++Q   +++ +EK+E   L   ++    + +E +K
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE---LYGKLRSTEANKKETEK 1662

Query: 589  ELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVI 648
            +L +  E++  E  +  ++  K  QQ I         LE++++  +L             
Sbjct: 1663 QLQE-AEQEMEEMKEKMRKFAKSKQQKI---------LELEEENDRLR------------ 1700

Query: 649  SVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVA 708
              AE+  A    K   E+ L+S A+  +E +  K+  + L K  + +  E   +S  +V 
Sbjct: 1701 --AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS-EEVQ 1757

Query: 709  EIVATLEKEEKVEEKEKAKEKAEKE 733
            ++   +E     +   +A EK + +
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQ 1782



 Score = 30.0 bits (66), Expect = 8.1
 Identities = 42/192 (21%), Positives = 86/192 (44%), Gaps = 21/192 (10%)

Query: 431  DQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEA-AIQQEHREKELQKRS 489
            D+    ++TL  I  +  Q K       Q+D+  K  ++LQ +   I  ++++ E +  S
Sbjct: 2436 DKTNQLMETLKTIKKENIQQKA------QLDSFVKSMSSLQNDRDRIVGDYQQLEERHLS 2489

Query: 490  EVAKDFEPERVVAAPQRPGTEP----QPEMPDTVLQSETLKDTAPVLEGLKE-------- 537
             + +  +  +  AA      E     +  M D  L SE  K  A +++  ++        
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIRGLRSHMDD--LNSENAKLDAELIQYREDLNQVITIK 2547

Query: 538  EEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEK 597
            +   K+ +++      +L+ +   L ++ +E E   ED++     LQE K++LSK  E  
Sbjct: 2548 DSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL 2607

Query: 598  YVEESKASKRLT 609
             V  S+ ++++T
Sbjct: 2608 KVSISQLTRQVT 2619


>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 114/542 (21%), Positives = 234/542 (43%), Gaps = 92/542 (16%)

Query: 225 LPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATK 284
           + +  + F  M     E + L + RL        EL K  QD  EE+  +N+  K     
Sbjct: 318 ITINARKFEEMNAELEENKELAQNRL-------CELEKLRQD-FEEVTTQNEKLKVELR- 368

Query: 285 DFSVFFQKIRETGERPSNEEIMRFSKLFEDEL----------TLDNLTRPQLVALCKLLE 334
             S   Q ++ET E    +   +FS L+ + L          TL + TR       +L+E
Sbjct: 369 --SAVEQVVKETPEYRCMQS--QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIE 424

Query: 335 LQSIGTNNFLR---FQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMR----AL 387
              +  +  LR    QL   L  ++ + +++  E   +L   E QA    R MR    +L
Sbjct: 425 RDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANE-QAGPINREMRHLISSL 483

Query: 388 GVTEDRLRGQLKQWL--------DLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQT 439
                +L+G++ ++         DL+  +    S L+ S++     T  P D+       
Sbjct: 484 QNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQS----STEDPKDEPAELKPD 539

Query: 440 LPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPER 499
             ++ ++ +  K ++ +  ++ +K       ++E   ++E REKE ++  E  K+ E ER
Sbjct: 540 SEDLSSQSSASKASQEDANEIKSK-------RDEEERERERREKEREREREREKEKERER 592

Query: 500 VVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSD---ACSKLQ 556
                     E Q      + +SE  +D+A   E  K ++  K+E +I+        K Q
Sbjct: 593 ----------EKQK-----LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQ 637

Query: 557 EQKKSL-----------TKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESK-- 603
           E +K +            +++++++L+  + +  +E L+++++ L K  E+K  +E+K  
Sbjct: 638 ESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAE-LEDLRQRL-KDLEDKEKKENKKM 695

Query: 604 ASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAEL-INAMKQVKH 662
           A +   ++++ +  QI+ L  +L M +Q  +   +    TG+    + E  I  M+Q++ 
Sbjct: 696 ADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755

Query: 663 IPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEE 722
             ++    ++  +  N+  K+  ++  ++ + V         +   ++ A L+   K+EE
Sbjct: 756 KDDANFKLMSERIKSNQIHKLLKEEKEELADQV--------LTLKTQVDAQLQVVRKLEE 807

Query: 723 KE 724
           KE
Sbjct: 808 KE 809


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 86/407 (21%), Positives = 167/407 (41%), Gaps = 60/407 (14%)

Query: 344 LRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLD 403
           LR Q+     S+K  ++ + E       V E Q A R    + L    +     L++  D
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKE-------VAEKQEATRQDHAQQLATAAEEREASLRE-RD 600

Query: 404 LHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNK 463
             L Q         ++   L   L  A++ + + QT       +AQ + AE+  +  + +
Sbjct: 601 AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS----VTQAQREKAELSRKVEELQ 656

Query: 464 AKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSE 523
           A +E   QE+   Q +  E ELQ RSE  K  E ERV             E      Q +
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA-----------QEKDQLQEQLQ 705

Query: 524 TLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDL 583
            LK++  V +G  EEE  +        A   L+EQ++ +++ K E   L E  +   ++L
Sbjct: 706 ALKESLKVTKGSLEEEKRR--------AADALEEQQRCISELKAETRSLVEQHKRERKEL 757

Query: 584 QE-------IKKELSKTGEEKYVEESKASKRLTKRV----------QQMIGQIDGLISQL 626
           +E       ++  L + GE    E     + L + +          +Q++ ++     + 
Sbjct: 758 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY 817

Query: 627 EMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKL------TSLAAALDENKD 680
           E  QQ        G    E ++++ E     +Q     + K+      + L  +  +N+ 
Sbjct: 818 EDSQQE---EAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNEL 874

Query: 681 GKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAK 727
            +++  +L + ++ V +++V     ++A+ ++TL+++     KE A+
Sbjct: 875 AELHA-NLARALQQVQEKEVR--AQKLADDLSTLQEKMAATSKEVAR 918



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 81/354 (22%), Positives = 148/354 (41%), Gaps = 41/354 (11%)

Query: 393 RLRGQLKQWLDLHLHQ-EIPTSLLILSR-----AMYLPDTLSPADQLKSTLQTLPEIVAK 446
           RL   LKQ  DL   + ++   +  LS      +  L +  S   QL+  L  L E  +K
Sbjct: 291 RLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350

Query: 447 EAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEV--AKDFEPERVVAAP 504
             Q        E ++ +A+LE  L   AA+Q +   K L++++E+   K  + E  ++  
Sbjct: 351 ATQ--------EWLEKQAQLEKELS--AALQDK---KCLEEKNEILQGKLSQLEEHLSQL 397

Query: 505 QRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTK 564
           Q    + + E+   VLQ ETLK  A  L     +   +  +++L    ++  +Q+  L  
Sbjct: 398 QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQ--LQARVEMLE---TERGQQEAKLLA 452

Query: 565 EKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLIS 624
           E+   E  K+ +     DLQ     LS+  EE          RLT +V  +  ++  L +
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512

Query: 625 QLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVN 684
            ++  QQ  +LA        E    +A+ +   +Q       ++  L+++L + +     
Sbjct: 513 TIQ--QQDQELAGLK-QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ---- 565

Query: 685 IDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKE---KAKEKAEKEVA 735
                ++ E+ +K++            A  E+E  + E++   K  E  EKE A
Sbjct: 566 -----QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 108/532 (20%), Positives = 219/532 (41%), Gaps = 100/532 (18%)

Query: 248  ERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMR 307
            E L+KE   KLE+ +      +++ + N+A   + T            T  +    E+ R
Sbjct: 607  EALEKEKAAKLEILQ------QQLQVANEARDSAQTS----------VTQAQREKAELSR 650

Query: 308  FSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGV 367
              K+ E +  ++   + Q  A  ++ EL+           L +R    KA +K    +  
Sbjct: 651  --KVEELQACVETARQEQHEAQAQVAELE-----------LQLRSEQQKATEKERVAQEK 697

Query: 368  DSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLD-LHLHQEIPTSLLILSRAMY---- 422
            D L  ++LQA        +L VT+  L  + ++  D L   Q   + L   +R++     
Sbjct: 698  DQLQ-EQLQAL-----KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751

Query: 423  -----LPDTLSPADQLKSTLQTLPEIVAKEAQV---KVAEVEGEQVDNKAKLEATLQEEA 474
                 L +  +    L++ LQ L E    E +V   ++AE    Q   +++ E  ++E A
Sbjct: 752  RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811

Query: 475  AIQQEHRE-------------KELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQ 521
            A ++ + +             ++L    E  +    E   A  +  G E   E+  +  Q
Sbjct: 812  AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871

Query: 522  SETLK---DTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQD 578
            +E  +   + A  L+ ++E+E+  ++   L+D  S LQE+  + +KE   LE L     +
Sbjct: 872  NELAELHANLARALQQVQEKEVRAQK---LADDLSTLQEKMAATSKEVARLETLVRKAGE 928

Query: 579  YSEDL-QEIKKELSKTGEE--KYVEESK---------ASKRLTKRVQQMIGQIDGLISQL 626
              E   +E+ KE ++ G+   +++EE +         A + + +  +QM  +++ L + L
Sbjct: 929  QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988

Query: 627  ------------EMDQQAGKLAPANGMPTGENVISVA-------ELINAMKQVKHIPESK 667
                        + +++  +L    G    +  +  A        L NA+ + +    + 
Sbjct: 989  MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048

Query: 668  LTSLAAALDENKDGKVNIDDL--VKVIELVDKEDVHISTSQVAEIVATLEKE 717
              +LA AL E +     +  L  ++  ++ + E++  +  Q+ E +A  EKE
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 21/207 (10%)

Query: 432  QLKSTLQTLPEIVAKE--AQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREK--ELQK 487
            + +ST + L  + AK   A+VKV E      + + KL A +++    Q+E  ++  EL K
Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK 1556

Query: 488  R---SEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEE-----E 539
            +   S+ A   + +++ A  Q  G E Q E      Q   L+      E   E      E
Sbjct: 1557 KLADSDQASKVQQQKLKAV-QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQME 1615

Query: 540  ITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYV 599
              K   D       +LQEQ +SL + ++E + L+ + +    +LQ+           K  
Sbjct: 1616 KAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQ--------AGLKTK 1667

Query: 600  EESKASKRLTKRVQQMIGQIDGLISQL 626
            E  +  + LT +V+ +  Q+     QL
Sbjct: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQL 1694



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 48/220 (21%), Positives = 89/220 (40%), Gaps = 19/220 (8%)

Query: 470  LQEEAAIQQEHREKEL-QKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDT 528
            L E A + ++  E EL Q R +  ++    R  A  +    + + +     L+  T K  
Sbjct: 1454 LGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYE 1513

Query: 529  APVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKK 588
               ++ L+E +  +EE   L+    +L+  ++  TK+ EEL     D    S+  Q+  K
Sbjct: 1514 GAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLK 1573

Query: 589  ELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVI 648
             +   G E        S++  +R+Q  + ++   +SQ E   +  KL           + 
Sbjct: 1574 AVQAQGGE--------SQQEAQRLQAQLNELQAQLSQKEQAAEHYKL----------QME 1615

Query: 649  SVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDL 688
                  +A KQ     + +L SL     ENK+ +   + L
Sbjct: 1616 KAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERL 1655



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 53/216 (24%), Positives = 90/216 (41%), Gaps = 33/216 (15%)

Query: 442  EIVAKEAQVKVAEVEGEQVDNKAKLE-ATLQE---EAAIQQEHREKELQK----RSEVAK 493
            ++  ++A     E+  +   N+ ++E ATLQE    A  ++E +++EL K     +   K
Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078

Query: 494  DFEPER--VVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDA 551
            + E  R  V    ++   + +     +  QSE    T P    L   E  + E+  L   
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL---EALRAEVSKLEQQ 1135

Query: 552  CSKLQEQKKSLTKEKE-----------ELELLKEDVQDYSEDLQEIKKELSKTGEE---- 596
            C K QEQ  SL +  E            LE L+  +++ +++L   +  L+    E    
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195

Query: 597  --KYVEESKAS---KRLTKRVQQMIGQIDGLISQLE 627
              K  + SKA    K    R +Q   + + LIS LE
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE 1231


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 118/523 (22%), Positives = 213/523 (40%), Gaps = 85/523 (16%)

Query: 241  ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP 300
            E +SLK ++          L +  Q  +E++  K +  K +  KD  + FQ   E     
Sbjct: 615  ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE---- 670

Query: 301  SNEEIMRFSKLFEDEL-TLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADD 359
             NE+ +    + + EL +L +     L A  KL E  S+  +     ++   L +   + 
Sbjct: 671  MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ--TDKMKQELEAKMDEQ 728

Query: 360  KLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSR 419
            K   ++ VDS+ +KE + + +         TE  L+ Q+ Q             LL+  R
Sbjct: 729  KNHHQQQVDSI-IKEHEVSIQR--------TEKALKDQINQ-----------LELLLKER 768

Query: 420  AMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQE 479
              +L +  +  + L             EA +K +E E +Q   K  +  + Q     Q +
Sbjct: 769  DKHLKEHQAHVENL-------------EADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815

Query: 480  HREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETL--KDTAPVLEGLKE 537
              E++L +  +   D E ER++   Q    E Q +   T L +  +  +D    LE    
Sbjct: 816  AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875

Query: 538  E------EITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELS 591
            E       +T+     L D  +K QEQ K +  EKE + L   + Q   ++++ + ++LS
Sbjct: 876  EMEQKVKSLTQVYESKLEDG-NKEQEQTKQILVEKENMILQMREGQ--KKEIEILTQKLS 932

Query: 592  KTGE------EKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGE 645
               +      E+Y  + K  ++  ++V+Q   ++   + +  +DQ+A KL         E
Sbjct: 933  AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA-KLKK-------E 984

Query: 646  NVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTS 705
               +  EL    KQ      +K+  +A A          I D V  +E   KE +   T 
Sbjct: 985  LENTALELSQKEKQF----NAKMLEMAQA------NSAGISDAVSRLETNQKEQIESLTE 1034

Query: 706  ----QVAEIVATLEK------EEKVEEKEKAKEKAEKEVAEVK 738
                ++ ++++  EK      EE  E  E   ++ E+EVAE+K
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 64/309 (20%), Positives = 134/309 (43%), Gaps = 35/309 (11%)

Query: 432 QLKSTLQTLPEIVAK-EAQVKVAEVEGEQV-DNKAKLEATLQEEA--AIQQEHREKELQK 487
           Q+  TL+   E +A+  +++K    +GE++ + K K E    EE   A+    + +E ++
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 488 RSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDI 547
           + +   D + + +    +      Q E+      S   ++   V++   EE+I K +   
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQEL------SRVKQEVVDVMKKSSEEQIAKLQKLH 485

Query: 548 LSDACSKLQEQKKSL-TKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASK 606
             +   K QE  K L T+E+E  E +K         L++ + E  K  +EK  +ES A +
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVA-------LEKSQSEYLKISQEKEQQESLALE 538

Query: 607 RLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPES 666
            L  + + ++ + +  +  L+ + +  +               + EL ++++  K + E+
Sbjct: 539 ELELQKKAILTESENKLRDLQQEAETYR-------------TRILELESSLE--KSLQEN 583

Query: 667 KLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLE--KEEKVEEKE 724
           K  S   A+    +   +  ++  ++E    E   +   Q A     L+  K++   E E
Sbjct: 584 KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEME 643

Query: 725 KAKEKAEKE 733
           K +EK E+E
Sbjct: 644 KLREKCEQE 652



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 105/538 (19%), Positives = 234/538 (43%), Gaps = 69/538 (12%)

Query: 248  ERLKKELRVKLELAKFLQDTIEEMAL-----KNKAAK-GSATKDFSVFFQKIRETGERPS 301
            E+L+ +L   L+   FLQ+ + E+ +     K K ++  S  K     FQ ++ + E+ +
Sbjct: 1137 EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN 1196

Query: 302  N---EEIMRFSKLFEDELTLDNLTRPQLVALCK-----LLELQSIGTNNFLRFQLTMRLR 353
                ++ + F KL E+     ++   +  AL +     L+ + S  TN  L      + R
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256

Query: 354  SIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTS 413
            + K  + L+    + +  V EL+A  R        +TE++    +      H  +E    
Sbjct: 1257 TTKVKEALL----IKTCTVSELEAQLRQ-------LTEEQNTLNISFQQATHQLEEKENQ 1305

Query: 414  LLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDN-------KAKL 466
            +  +   +    T   A Q +   Q   +  A E +  + +++ E  +N       K +L
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQ---QQAASEKESCITQLKKELSENINAVTLMKEEL 1362

Query: 467  EATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLK 526
            +    E +++ ++  +  +Q ++ ++   E E  +++ ++   E + E+ D V      +
Sbjct: 1363 KEKKVEISSLSKQLTDLNVQLQNSISLS-EKEAAISSLRKQYDEEKCELLDQV------Q 1415

Query: 527  DTAPVLEGLKEEEITK-EEIDILSDACSKLQE-------QKKSLTKEKE-ELELLKEDVQ 577
            D +  ++ L +E+I+  E++D  S+  S+ ++       Q ++  KE + +LEL  ++  
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475

Query: 578  DYSEDLQEIKKELSKTGE-------EKYVEESKASKRLTKRVQQMIGQIDGLISQLE--M 628
            +  E +  +K+EL +  +       E   ++SK  K+ +    ++  Q    I +LE  +
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ-TARIMELEDHI 1534

Query: 629  DQQAGKLAPANGMPTGENV---ISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNI 685
             Q+  ++   N +    N    I   EL+  ++  + + E K   +  A ++    +  +
Sbjct: 1535 TQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594

Query: 686  DDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKA-----KEKAEKEVAEVK 738
              +   +E   KE  H++ S  ++       E+++E +  A     K KAE+++A +K
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK 1652



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 95/403 (23%), Positives = 165/403 (40%), Gaps = 83/403 (20%)

Query: 246 KEERLKKELRVKL-ELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEE 304
           K E  +++L+ ++ E  K ++ T EE  +       S  ++ S   Q++ +  ++ S E+
Sbjct: 425 KTEEARRKLKAEMDEQIKTIEKTSEEERI-------SLQQELSRVKQEVVDVMKKSSEEQ 477

Query: 305 IMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIA- 363
           I +  KL E EL            L K L+ +         FQ  M++   K+  + +  
Sbjct: 478 IAKLQKLHEKELARKEQE------LTKKLQTRE------REFQEQMKVALEKSQSEYLKI 525

Query: 364 ---EEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA 420
              +E  +SL ++EL+   +A     L  +E++LR          L QE  T        
Sbjct: 526 SQEKEQQESLALEELELQKKA----ILTESENKLRD---------LQQEAET-------- 564

Query: 421 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH 480
            Y    L     L+ +LQ        + Q K   V  E   NK   E T      +  E 
Sbjct: 565 -YRTRILELESSLEKSLQE------NKNQSKDLAVHLEAEKNKHNKEIT------VMVEK 611

Query: 481 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETL-KDTAPVLEGLKEE- 538
            + EL+           E++    Q+  TE +        + ETL KD   + +   EE 
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671

Query: 539 -EITKEEIDI----LSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKEL-SK 592
            E T E++D+    L    S+L E  K+  K +EEL +LK+          ++K+EL +K
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD-------KMKQELEAK 724

Query: 593 TGEEK---------YVEESKAS-KRLTKRVQQMIGQIDGLISQ 625
             E+K          ++E + S +R  K ++  I Q++ L+ +
Sbjct: 725 MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 86/420 (20%), Positives = 181/420 (43%), Gaps = 47/420 (11%)

Query: 331  KLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEE-GVDSLNVKELQAACRARGMRALGV 389
            KLL+L++       R  LT ++  ++A  K +  E     + V++L      +       
Sbjct: 827  KLLDLETE------RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880

Query: 390  TEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQ 449
             +   +    +  D +  QE    +L+    M L        +++   Q L    AKE  
Sbjct: 881  VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS---AKEDS 937

Query: 450  VKVA--EVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERV-VAAPQR 506
            + +   E E +  + + K+E   Q+   +Q+  ++K L + +++ K+ E   + ++  ++
Sbjct: 938  IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997

Query: 507  PGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI---TKEEIDILSDACSKLQEQKKSLT 563
                   EM      S  + D    LE  ++E+I   T+     L+D  S  +   K L 
Sbjct: 998  QFNAKMLEMAQA--NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE---KKLN 1052

Query: 564  KEKEELELLKE-DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGL 622
            ++ EEL+ + E  +Q+  +++ E+K+++   G EK     + +K +T   ++ + Q D  
Sbjct: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK----EEMNKEITWLKEEGVKQ-DTT 1107

Query: 623  ISQLEMDQQAGKLAPANGMPTGENVISV------AELINAMKQVKHIPESKLTSLAAALD 676
            +++L+ +Q   K A  N +   E  +         +L  ++K+   + E +L  L    +
Sbjct: 1108 LNELQ-EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE-QLVELKMLAE 1165

Query: 677  ENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEK-VEEKEKAKEKAEKEVA 735
            E+K     + +L   ++  D+E   + +S         EK  K +E+K    +K  +E+A
Sbjct: 1166 EDKR---KVSELTSKLKTTDEEFQSLKSSH--------EKSNKSLEDKSLEFKKLSEELA 1214



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 111/546 (20%), Positives = 214/546 (39%), Gaps = 76/546 (13%)

Query: 246  KEERLKKELRVKLELAKFLQDTIEEMA---------LKN-KAAKGSATKDFSVFFQKIRE 295
            KE  L+ EL+ +      L+D I +           LKN    K    K+     Q  +E
Sbjct: 1512 KESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE 1571

Query: 296  TGERPSNEEIMRFSKLFEDELTLDNLTRPQLVAL-CKLLELQSIGTNNFLRFQLTMRLRS 354
             GE   N    R  +  E  LTL+N        L  K  EL+ +  +      +  +   
Sbjct: 1572 LGEEKDN----RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS------VKSKEEE 1621

Query: 355  IKA-DDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTS 413
            +KA +D+L +E       +K       A   + L    +    Q K+  + HL  E+ T 
Sbjct: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL-SELNTK 1680

Query: 414  LLILSRAMYLPDTLSPADQLKSTLQTLPE--IVAKEAQVKVAEVEGEQVDNKAKLEATLQ 471
            L    R +++ +     ++LKS   +  E  IV + A+   A  E E+ D++  ++ T +
Sbjct: 1681 LQEREREVHILE-----EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE 1735

Query: 472  EEAAIQQEH---REKELQ-----KRSEVAKDFE-----PERVVAAPQRPGTEPQPEMPDT 518
            E+ ++ Q +   +EK LQ     K   V+  FE      ER++        + + +    
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIG 1795

Query: 519  VLQSETLKDTAPVL---------EGLKEEEITKEEIDILSDACSKLQEQKK--------- 560
             LQ E  +               EG K     K+ ++ + D   K  ++K+         
Sbjct: 1796 HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK 1855

Query: 561  ------SLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQ- 613
                   L ++KE   +  E++    E LQ +++   +    + +EE+   K  +  VQ 
Sbjct: 1856 IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQP 1915

Query: 614  QMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAA 673
            +++  ++   + LE  + AG  A       G+ ++    L   ++ ++   + +L  L  
Sbjct: 1916 KLLSNMEAQHNDLEF-KLAG--AEREKQKLGKEIV---RLQKDLRMLRKEHQQELEILKK 1969

Query: 674  ALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKE 733
              D+ ++ K+  +   + +EL     +     +    +A  E+E ++  KE   +  E E
Sbjct: 1970 EYDQEREEKIKQEQ--EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 734  VAEVKS 739
               ++S
Sbjct: 2028 AELLES 2033



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 58/299 (19%), Positives = 126/299 (42%), Gaps = 46/299 (15%)

Query: 455  VEGEQVDNKAKLE---ATLQEEAAIQ-------QEH---REKELQKRSEVAKDFEPERVV 501
            ++GE  D+K+K+E   + L+ E   Q       ++H   +  E++  +EV K++  ++ +
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI 1557

Query: 502  AAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKS 561
                        E  + V + +  ++      G +++   KE  + +    +++   K  
Sbjct: 1558 ------------EHKELVQKLQHFQEL-----GEEKDNRVKEAEEKILTLENQVYSMKAE 1600

Query: 562  LTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQI-D 620
            L  +K+ELE +   V+   E+L+ ++  L      K  E       L ++ +Q I  I  
Sbjct: 1601 LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE-------LKRKAEQKIAAIKK 1653

Query: 621  GLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKD 680
             L+SQ+E  ++  K        T  ++  +   +   ++  HI E KL S+ ++  E   
Sbjct: 1654 QLLSQMEEKEEQYKKG------TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707

Query: 681  GKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS 739
               +  ++    E  + +          E ++ L++   + EKEK  ++  +E  E  S
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR--NLTEKEKLLQRVGQEKEETVS 1764



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 47/244 (19%), Positives = 109/244 (44%), Gaps = 29/244 (11%)

Query: 521 QSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYS 580
           Q ++L+  A + E L+ ++  K+ +    DA   L+E+ + ++  + ++ LLK+ +++  
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDA--SLEEKDQYISVLQTQVSLLKQRLRNGP 239

Query: 581 EDLQEIK-------------KELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLE 627
            ++  +K             KE +   + + V E   S +  + +QQ + + + L+ + +
Sbjct: 240 MNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCK 299

Query: 628 MDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDD 687
              Q+ K      + T E      +L   +++++ I +  +      + + +D K  I+ 
Sbjct: 300 ETIQSHKEQCT--LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357

Query: 688 LVKVIELV---DKEDVHISTSQVAEIVA---------TLEKEEKVEEKEKAKEKAEKEVA 735
           L +   +V    K  +H +     E +A         T + EE  E+KEK++  A +E+ 
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417

Query: 736 EVKS 739
           +  S
Sbjct: 418 KALS 421


>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
           sapiens]
          Length = 693

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 74/294 (25%), Positives = 137/294 (46%), Gaps = 37/294 (12%)

Query: 345 RFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRA--------LGVTEDRLRG 396
           R Q T++ R++         E +  + ++  + A   +G RA        + V    L+ 
Sbjct: 200 RLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE 259

Query: 397 QLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVE 456
           + K+  D+H  QE+  SL  L   M  P +L+P   + S ++ L +  AK  + +V  +E
Sbjct: 260 EKKR--DIHRIQELERSLSELKNQMAKPPSLAP-PAVTSVVEQLQD-EAKHLRQEVEGLE 315

Query: 457 GE---QVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQP 513
           G+   QV+N   L    +E+    QE  ++E+ +  EV +  E ER+    +R   E Q 
Sbjct: 316 GKLQSQVENNQALSLLSKEQKQRLQE--QEEMLREQEVQRVREQERLCEQNERL-REQQK 372

Query: 514 EMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLK 573
            + +   Q E L+     L   +EE + KEE         +LQ+Q+K L  ++E L   +
Sbjct: 373 TLQE---QGERLRKQEQRLR-KQEERLRKEE--------ERLQKQEKRLWDQEERLWKKE 420

Query: 574 EDVQDYSEDL-----QEIKKELS--KTGEEKYVEESKASKRLTKRVQQMIGQID 620
           E +Q   E L      ++ K+L+  +   E    E K++ +L ++V+++  ++D
Sbjct: 421 ERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLD 474



 Score = 36.6 bits (83), Expect = 0.086
 Identities = 41/170 (24%), Positives = 81/170 (47%), Gaps = 9/170 (5%)

Query: 463 KAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS 522
           K  +EA   +E   +  HR +EL++     K+   +    AP    T    ++ D   ++
Sbjct: 249 KMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAKPPSLAPPAV-TSVVEQLQD---EA 304

Query: 523 ETLKDTAPVLEGLKEEEITKEE-IDILS-DACSKLQEQKKSLTKEKEELELLKEDVQDYS 580
           + L+     LEG  + ++   + + +LS +   +LQEQ++ L +++ +    +E + + +
Sbjct: 305 KHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQN 364

Query: 581 EDLQEIKKELSKTGEEKYVEES---KASKRLTKRVQQMIGQIDGLISQLE 627
           E L+E +K L + GE    +E    K  +RL K  +++  Q   L  Q E
Sbjct: 365 ERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEE 414



 Score = 33.1 bits (74), Expect = 0.95
 Identities = 71/340 (20%), Positives = 140/340 (41%), Gaps = 49/340 (14%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQ--EEAAIQQEHREKELQKRS 489
           QL+   +T  EI   +AQ++  E        KA L+ TL   + AA   E   K+L  R 
Sbjct: 105 QLEEAKKTNNEI--HKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRL 162

Query: 490 EVA----KDFEPERVVAAPQRPGTEPQPEMPDTVLQ---SETLKDTA-------PVLEGL 535
           + +    ++ E      + Q+   +      + VL     +T+K+ A        V E L
Sbjct: 163 QYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHVTQVTESL 222

Query: 536 KEEEITKEEI-DILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG 594
           K+ ++ ++E    +    ++ QE+   + K   E   LKE+ +     +QE+++ LS+  
Sbjct: 223 KQVQLERDEYAKHIKGERARWQER---MWKMSVEARTLKEEKKRDIHRIQELERSLSELK 279

Query: 595 EEKYVEESKASKRLTKRVQQMIG-------QIDGLISQLEMD------------QQAGKL 635
            +     S A   +T  V+Q+         +++GL  +L+              +Q  +L
Sbjct: 280 NQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRL 339

Query: 636 APANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELV 695
                M   + V  V E     +Q + + E + T      ++ +  +     L K  E +
Sbjct: 340 QEQEEMLREQEVQRVREQERLCEQNERLREQQKT----LQEQGERLRKQEQRLRKQEERL 395

Query: 696 DKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVA 735
            KE+  +   +        ++EE++ +KE+  +K E+ +A
Sbjct: 396 RKEEERLQKQE----KRLWDQEERLWKKEERLQKQEERLA 431


>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
            sapiens]
          Length = 1907

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 73/342 (21%), Positives = 147/342 (42%), Gaps = 30/342 (8%)

Query: 413  SLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQE 472
            ++L++   +Y       +++LK+ ++   E+V K +  +    E ++   + + +  +  
Sbjct: 1200 TVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILS 1259

Query: 473  EAAIQQEHREKELQKRSEVAKDFEPE-RVVAAPQRP-GTEPQPEMPDTVLQSETLKDT-- 528
            + AI+ + + K L+K  E+  D     RV+   +R    + Q  + +     E LKD   
Sbjct: 1260 DEAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVIS 1319

Query: 529  ------APVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSED 582
                  + V   L E ++++E++      C ++QE+   L K+KE+L+   ED      +
Sbjct: 1320 MNASEFSEVQIALNEAKLSEEKV---KSECHRVQEENARLKKKKEQLQQEIEDWSKLHAE 1376

Query: 583  LQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQ--AGKLAP--A 638
            L E  K   K+ ++  V  +     +   +   I Q++ L  + E + Q   G  +   A
Sbjct: 1377 LSEQIKSFEKSQKDLEVALTHKDDNI-NALTNCITQLNLLECESESEGQNKGGNDSDELA 1435

Query: 639  NGMPTGENVISVAELINAMKQVKH------IPESKLTSLAAALDENKDGKVNIDDLVKVI 692
            NG   G+    +   I  M  V        + E  L  L   L  +   K N++D VK +
Sbjct: 1436 NGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKL 1495

Query: 693  ELVDKEDVHISTSQVAEIVATLEKE-----EKVEEKEKAKEK 729
            E  D+  +  + + + +   TL ++     E  ++KE A +K
Sbjct: 1496 E-DDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQK 1536


>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
           sapiens]
          Length = 693

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 65/291 (22%), Positives = 138/291 (47%), Gaps = 31/291 (10%)

Query: 345 RFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRA--------LGVTEDRLRG 396
           R Q T++ R++         E +  + ++  + A   +G RA        + V    L+ 
Sbjct: 200 RLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE 259

Query: 397 QLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVE 456
           + K+  D+H  QE+  SL  L   M  P +L+P       + ++ E +  EA+    EVE
Sbjct: 260 EKKR--DIHRIQELERSLSELKNQMAEPPSLAPP-----AVTSVVEQLQDEAKHLRQEVE 312

Query: 457 GEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMP 516
           G  ++ K + +    +  ++  + +++ LQ++ E+ ++ E +RV    Q    E    + 
Sbjct: 313 G--LEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRV--REQERLCEQNERLR 368

Query: 517 DTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDV 576
           +   Q +TL++    L   K+E+  +++ + L     +LQ+Q+K L  ++E L   +E +
Sbjct: 369 E---QQKTLQEQGERLR--KQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERL 423

Query: 577 QDYSEDL-----QEIKKELS--KTGEEKYVEESKASKRLTKRVQQMIGQID 620
           Q   E L      ++ K+L+  +   E    E K++ +L ++V+++  ++D
Sbjct: 424 QKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLD 474



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 42/170 (24%), Positives = 81/170 (47%), Gaps = 9/170 (5%)

Query: 463 KAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS 522
           K  +EA   +E   +  HR +EL++     K+   E    AP    T    ++ D   ++
Sbjct: 249 KMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAV-TSVVEQLQD---EA 304

Query: 523 ETLKDTAPVLEGLKEEEITKEE-IDILS-DACSKLQEQKKSLTKEKEELELLKEDVQDYS 580
           + L+     LEG  + ++   + + +LS +   +LQEQ++ L +++ +    +E + + +
Sbjct: 305 KHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQN 364

Query: 581 EDLQEIKKELSKTGEEKYVEES---KASKRLTKRVQQMIGQIDGLISQLE 627
           E L+E +K L + GE    +E    K  +RL K  +++  Q   L  Q E
Sbjct: 365 ERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEE 414



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 53/213 (24%), Positives = 94/213 (44%), Gaps = 22/213 (10%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQ--EEAAIQQEHREKELQKRS 489
           QL+   +T  EI   +AQ++  E        KA L+ TL   + AA   E   K+L  R 
Sbjct: 105 QLEEAKKTNNEI--HKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRL 162

Query: 490 EVAKDF--EPERVVAA--PQRPGTEPQPEMPDTVLQ---SETLKDTA-------PVLEGL 535
           + +     E ER + A   Q+   +      + VLQ    +T+K+ A        V E L
Sbjct: 163 QYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESL 222

Query: 536 KEEEITKEEI-DILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG 594
           K+ ++ ++E    +    ++ QE+   + K   E   LKE+ +     +QE+++ LS+  
Sbjct: 223 KQVQLERDEYAKHIKGERARWQER---MWKMSVEARTLKEEKKRDIHRIQELERSLSELK 279

Query: 595 EEKYVEESKASKRLTKRVQQMIGQIDGLISQLE 627
            +     S A   +T  V+Q+  +   L  ++E
Sbjct: 280 NQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVE 312


>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
           isoform 1 [Homo sapiens]
          Length = 693

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 65/291 (22%), Positives = 138/291 (47%), Gaps = 31/291 (10%)

Query: 345 RFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRA--------LGVTEDRLRG 396
           R Q T++ R++         E +  + ++  + A   +G RA        + V    L+ 
Sbjct: 200 RLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE 259

Query: 397 QLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVE 456
           + K+  D+H  QE+  SL  L   M  P +L+P       + ++ E +  EA+    EVE
Sbjct: 260 EKKR--DIHRIQELERSLSELKNQMAEPPSLAPP-----AVTSVVEQLQDEAKHLRQEVE 312

Query: 457 GEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMP 516
           G  ++ K + +    +  ++  + +++ LQ++ E+ ++ E +RV    Q    E    + 
Sbjct: 313 G--LEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRV--REQERLCEQNERLR 368

Query: 517 DTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDV 576
           +   Q +TL++    L   K+E+  +++ + L     +LQ+Q+K L  ++E L   +E +
Sbjct: 369 E---QQKTLQEQGERLR--KQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERL 423

Query: 577 QDYSEDL-----QEIKKELS--KTGEEKYVEESKASKRLTKRVQQMIGQID 620
           Q   E L      ++ K+L+  +   E    E K++ +L ++V+++  ++D
Sbjct: 424 QKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLD 474



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 42/170 (24%), Positives = 81/170 (47%), Gaps = 9/170 (5%)

Query: 463 KAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQS 522
           K  +EA   +E   +  HR +EL++     K+   E    AP    T    ++ D   ++
Sbjct: 249 KMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAV-TSVVEQLQD---EA 304

Query: 523 ETLKDTAPVLEGLKEEEITKEE-IDILS-DACSKLQEQKKSLTKEKEELELLKEDVQDYS 580
           + L+     LEG  + ++   + + +LS +   +LQEQ++ L +++ +    +E + + +
Sbjct: 305 KHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQN 364

Query: 581 EDLQEIKKELSKTGEEKYVEES---KASKRLTKRVQQMIGQIDGLISQLE 627
           E L+E +K L + GE    +E    K  +RL K  +++  Q   L  Q E
Sbjct: 365 ERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEE 414



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 53/213 (24%), Positives = 96/213 (45%), Gaps = 22/213 (10%)

Query: 432 QLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQ--EEAAIQQEHREKELQKRS 489
           QL+   +T  EI   +AQ++  E        KA L+ TL   + AA   E   K+L  R 
Sbjct: 105 QLEEAKKTNNEI--HKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRL 162

Query: 490 EVA--KDFEPERVVAA--PQRPGTEPQPEMPDTVLQ---SETLKDTA-------PVLEGL 535
           + +  +  E ER ++A   Q+   +      + VLQ    +T+K+ A        V E L
Sbjct: 163 QYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESL 222

Query: 536 KEEEITKEEI-DILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTG 594
           K+ ++ ++E    +    ++ QE+   + K   E   LKE+ +     +QE+++ LS+  
Sbjct: 223 KQVQLERDEYAKHIKGERARWQER---MWKMSVEARTLKEEKKRDIHRIQELERSLSELK 279

Query: 595 EEKYVEESKASKRLTKRVQQMIGQIDGLISQLE 627
            +     S A   +T  V+Q+  +   L  ++E
Sbjct: 280 NQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVE 312


>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
           [Homo sapiens]
          Length = 969

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 124/575 (21%), Positives = 236/575 (41%), Gaps = 87/575 (15%)

Query: 234 NMLPSTFETQSLKEERLKKELRVKLELA----KFLQDTIEEMALKNKAAKGSATKDFSVF 289
           N   +T   QS+ +  L  EL+ K++      K LQ+ + EM+ + K A+ S+ K     
Sbjct: 225 NSHETTITQQSVSDSHLA-ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGT- 282

Query: 290 FQKIRET---GERPSNE----------------EIMRFSKLFEDELTLDNLTRPQLVAL- 329
            Q ++ET    ER + E                E++  S+L +   +       Q VAL 
Sbjct: 283 IQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342

Query: 330 -------CKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRAR 382
                  C  LE+Q +     +R Q   +L   K   + +     +S   KE        
Sbjct: 343 DLQSALFCSQLEIQKL--QRVVR-QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 399

Query: 383 GMRALGVTEDRLRG---QLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQT 439
             +AL   ++ L+    QL+ W +   + EI T         +L  +LS  +QL    + 
Sbjct: 400 LRKALQQLQEELQNKSQQLRAW-EAEKYNEIRTQ---EQNIQHLNHSLSHKEQLLQEFRE 455

Query: 440 LPEI-----VAKEAQVKVAEVEGEQVDNKA-KLEATLQEE-AAIQQEHREKELQKRSEVA 492
           L +         EA   + E   +++ +KA  LE  + E+ +A++++ +E    + +   
Sbjct: 456 LLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 515

Query: 493 KDFEPER---VVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT------KE 543
           +D + ER   V+++ +      +  +    L+ E L  T   L+ LKEE  T      KE
Sbjct: 516 RDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE 575

Query: 544 EIDILSDACSKLQEQKKSLTK------------EKEELELLKEDVQDYSEDLQEIKKELS 591
           +  I+    + L ++ K +              + E  E L + +Q     LQ++  + +
Sbjct: 576 QESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRN 635

Query: 592 KTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVA 651
           K   E  +E     + ++ R Q+     + L+  L M++ +   A    +   ++++S A
Sbjct: 636 KQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL-MERNSELQALRQYLGGRDSLMSQA 694

Query: 652 ELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEI- 710
            + N         ++++T       +   G + I        L  KEDV I  S + ++ 
Sbjct: 695 PISN--------QQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 746

Query: 711 -VATLEKE-----EKVEEKEKAKEKAEKEVAEVKS 739
            VA LEKE     E++E   K + +++ E++ ++S
Sbjct: 747 TVAGLEKELSNAKEELELMAKKERESQMELSALQS 781



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 44/210 (20%), Positives = 96/210 (45%), Gaps = 20/210 (9%)

Query: 454 EVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQP 513
           +V G+QV      EA  Q +  I++ ++    Q+R       E ++++   + P +    
Sbjct: 153 DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ 212

Query: 514 EMPDTVLQSETLK--DTAPVLEGLKEEEITKEEIDI-LSDACSKLQEQKKSLTKEKEELE 570
            M + +L+ + L   +T    + + +  + + +  I  ++A +K+ ++K  L +   EL+
Sbjct: 213 PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK--LNEMSYELK 270

Query: 571 LLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMI-GQIDGLISQLEM- 628
             +E  Q     +Q +K+ L            K+ +R T+ + Q+I GQ D +    EM 
Sbjct: 271 CAQESSQKQDGTIQNLKETL------------KSRERETEELYQVIEGQNDTMAKLREML 318

Query: 629 -DQQAGKLAPANGMPTGENVISVAELINAM 657
              Q G+L  + G    +  +++ +L +A+
Sbjct: 319 HQSQLGQLHSSEGTSPAQQQVALLDLQSAL 348



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 30/156 (19%), Positives = 69/156 (44%), Gaps = 12/156 (7%)

Query: 566 KEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQ 625
           K E+E LK ++QD  + L +   ++     +    E++  ++  +R Q+     + L ++
Sbjct: 52  KVEVESLKRELQDKKQHLDKTWADVENLNSQ---NEAELRRQFEERQQETEHVYELLENK 108

Query: 626 LEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNI 685
           +++ Q+  +LA             +A L+ A K+       KL  +    ++    +V  
Sbjct: 109 IQLLQEESRLAK-------NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKP 161

Query: 686 DDLVKVIELVDK--EDVHISTSQVAEIVATLEKEEK 719
           D   + +   DK  E+++ S +    +V  L +E++
Sbjct: 162 DQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQ 197



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 46/227 (20%), Positives = 98/227 (43%), Gaps = 12/227 (5%)

Query: 471 QEEAAIQQEHREKELQKRSEVA--KDFEPERVVAAPQRPGTEPQPEM-PDTVLQSETLKD 527
           QE  A  ++  +  +++ SE+   + +   R     Q P +  Q E+ P   L  +T + 
Sbjct: 657 QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 716

Query: 528 TAPVLEGLKEEEIT-KEEIDILSDACSKLQEQ---KKSLTKEKEELELLKEDVQDYSEDL 583
           +  +        +T KE++ I       L      +K L+  KEELEL+ +  ++   +L
Sbjct: 717 SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL 776

Query: 584 QEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPT 643
             ++  ++   EE  V+ +   + LT+ +Q      + LI  L+M     +  PA    T
Sbjct: 777 SALQSMMAVQEEELQVQAAD-MESLTRNIQIK----EDLIKDLQMQLVDPEDIPAMERLT 831

Query: 644 GENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK 690
            E ++   ++ +   Q + I  ++   L   L+   D +  +++ ++
Sbjct: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQ 878


>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
           [Homo sapiens]
          Length = 1132

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 124/575 (21%), Positives = 236/575 (41%), Gaps = 87/575 (15%)

Query: 234 NMLPSTFETQSLKEERLKKELRVKLELA----KFLQDTIEEMALKNKAAKGSATKDFSVF 289
           N   +T   QS+ +  L  EL+ K++      K LQ+ + EM+ + K A+ S+ K     
Sbjct: 388 NSHETTITQQSVSDSHLA-ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGT- 445

Query: 290 FQKIRET---GERPSNE----------------EIMRFSKLFEDELTLDNLTRPQLVAL- 329
            Q ++ET    ER + E                E++  S+L +   +       Q VAL 
Sbjct: 446 IQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 505

Query: 330 -------CKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRAR 382
                  C  LE+Q +     +R Q   +L   K   + +     +S   KE        
Sbjct: 506 DLQSALFCSQLEIQKL--QRVVR-QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 562

Query: 383 GMRALGVTEDRLRG---QLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQT 439
             +AL   ++ L+    QL+ W +   + EI T         +L  +LS  +QL    + 
Sbjct: 563 LRKALQQLQEELQNKSQQLRAW-EAEKYNEIRTQ---EQNIQHLNHSLSHKEQLLQEFRE 618

Query: 440 LPEI-----VAKEAQVKVAEVEGEQVDNKA-KLEATLQEE-AAIQQEHREKELQKRSEVA 492
           L +         EA   + E   +++ +KA  LE  + E+ +A++++ +E    + +   
Sbjct: 619 LLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 678

Query: 493 KDFEPER---VVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEIT------KE 543
           +D + ER   V+++ +      +  +    L+ E L  T   L+ LKEE  T      KE
Sbjct: 679 RDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE 738

Query: 544 EIDILSDACSKLQEQKKSLTK------------EKEELELLKEDVQDYSEDLQEIKKELS 591
           +  I+    + L ++ K +              + E  E L + +Q     LQ++  + +
Sbjct: 739 QESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRN 798

Query: 592 KTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVA 651
           K   E  +E     + ++ R Q+     + L+  L M++ +   A    +   ++++S A
Sbjct: 799 KQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL-MERNSELQALRQYLGGRDSLMSQA 857

Query: 652 ELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEI- 710
            + N         ++++T       +   G + I        L  KEDV I  S + ++ 
Sbjct: 858 PISN--------QQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909

Query: 711 -VATLEKE-----EKVEEKEKAKEKAEKEVAEVKS 739
            VA LEKE     E++E   K + +++ E++ ++S
Sbjct: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQS 944



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 46/227 (20%), Positives = 98/227 (43%), Gaps = 12/227 (5%)

Query: 471  QEEAAIQQEHREKELQKRSEVA--KDFEPERVVAAPQRPGTEPQPEM-PDTVLQSETLKD 527
            QE  A  ++  +  +++ SE+   + +   R     Q P +  Q E+ P   L  +T + 
Sbjct: 820  QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 879

Query: 528  TAPVLEGLKEEEIT-KEEIDILSDACSKLQEQ---KKSLTKEKEELELLKEDVQDYSEDL 583
            +  +        +T KE++ I       L      +K L+  KEELEL+ +  ++   +L
Sbjct: 880  SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL 939

Query: 584  QEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPT 643
              ++  ++   EE  V+ +   + LT+ +Q      + LI  L+M     +  PA    T
Sbjct: 940  SALQSMMAVQEEELQVQAAD-MESLTRNIQIK----EDLIKDLQMQLVDPEDIPAMERLT 994

Query: 644  GENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK 690
             E ++   ++ +   Q + I  ++   L   L+   D +  +++ ++
Sbjct: 995  QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQ 1041


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,039,170
Number of Sequences: 37866
Number of extensions: 1392548
Number of successful extensions: 17527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 945
Number of HSP's that attempted gapping in prelim test: 10806
Number of HSP's gapped (non-prelim): 4942
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.