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Search of human proteins with 66346662
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi... 952 0.0
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens] 869 0.0
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi... 869 0.0
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 441 e-124
gi|56119110 family with sequence similarity 13, member A1 isofor... 105 1e-22
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 104 2e-22
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 104 2e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 104 2e-22
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 103 4e-22
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 96 7e-20
gi|188497642 ARHGAP15 [Homo sapiens] 95 2e-19
gi|51479148 Rho GTPase activating protein 20 [Homo sapiens] 95 2e-19
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 92 8e-19
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 91 2e-18
gi|21314774 T-cell activation Rho GTPase-activating protein isof... 91 2e-18
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 89 6e-18
gi|54860079 nadrin isoform 1 [Homo sapiens] 89 6e-18
gi|54860105 nadrin isoform 2 [Homo sapiens] 89 6e-18
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 89 8e-18
gi|156119615 myosin IXA [Homo sapiens] 89 1e-17
gi|20270373 T-cell activation Rho GTPase-activating protein isof... 88 1e-17
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 87 2e-17
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 87 2e-17
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 87 3e-17
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 87 3e-17
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 86 7e-17
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 86 7e-17
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 85 1e-16
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 85 1e-16
gi|91208437 GEM interacting protein [Homo sapiens] 83 5e-16
>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
sapiens]
Length = 464
Score = 952 bits (2460), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 60
MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY
Sbjct: 1 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 60
Query: 61 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSS 120
TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSS
Sbjct: 61 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSS 120
Query: 121 HLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 180
HLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL
Sbjct: 121 HLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 180
Query: 181 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 240
KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI
Sbjct: 181 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 240
Query: 241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK
Sbjct: 241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
Query: 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 360
TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS
Sbjct: 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 360
Query: 361 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 420
RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE
Sbjct: 361 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 420
Query: 421 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 464
HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL
Sbjct: 421 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 464
>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
Length = 555
Score = 869 bits (2246), Expect = 0.0
Identities = 433/464 (93%), Positives = 433/464 (93%), Gaps = 31/464 (6%)
Query: 1 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 60
MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY
Sbjct: 123 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 182
Query: 61 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSS 120
TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRK
Sbjct: 183 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRK-------------------- 222
Query: 121 HLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 180
YKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL
Sbjct: 223 -----------YKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 271
Query: 181 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 240
KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI
Sbjct: 272 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 331
Query: 241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK
Sbjct: 332 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 391
Query: 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 360
TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS
Sbjct: 392 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 451
Query: 361 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 420
RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE
Sbjct: 452 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 511
Query: 421 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 464
HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL
Sbjct: 512 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 555
>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
sapiens]
Length = 433
Score = 869 bits (2246), Expect = 0.0
Identities = 433/464 (93%), Positives = 433/464 (93%), Gaps = 31/464 (6%)
Query: 1 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 60
MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY
Sbjct: 1 MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKY 60
Query: 61 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSS 120
TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRK
Sbjct: 61 TLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRK-------------------- 100
Query: 121 HLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 180
YKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL
Sbjct: 101 -----------YKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHL 149
Query: 181 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 240
KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI
Sbjct: 150 KYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELI 209
Query: 241 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 300
PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK
Sbjct: 210 PPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILK 269
Query: 301 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 360
TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS
Sbjct: 270 TFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 329
Query: 361 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 420
RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE
Sbjct: 330 RESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGE 389
Query: 421 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 464
HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL
Sbjct: 390 HGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL 433
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 441 bits (1135), Expect = e-124
Identities = 219/413 (53%), Positives = 286/413 (69%), Gaps = 33/413 (7%)
Query: 8 LSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVE 67
L P+YD+ARH I++VAGDD++GR+++ FS CRMPPSH+LDH +LL YLK+TLDQYVE
Sbjct: 58 LKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVE 117
Query: 68 NDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKY 127
+DYT++Y H+GL S NKPSL WL+ AY+EFDRK
Sbjct: 118 SDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRK--------------------------- 150
Query: 128 WDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVI 187
YKKN+KALY+VHPT FIK L + KPLIS KFG+K+ Y NYLSEL EH+K +QL I
Sbjct: 151 ----YKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGI 206
Query: 188 PPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKN-QGELIPPVLRF 246
P +VL+YD+ L+S + P K PPRPPLP QQFGVSLQ+L++KN + E IP VLR
Sbjct: 207 PRQVLKYDDFLKSTQKSPATAP-KPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRE 265
Query: 247 TVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLREL 306
TV YL+ L TEG+FRRSA+ Q VRE+Q+ YN G PV+FD Y ++H+PAVILKTFLREL
Sbjct: 266 TVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLREL 325
Query: 307 PQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFN 366
P+PLLTF Y ++G ++ S RV Q+L++LPE NY VLR+L FL +S S N
Sbjct: 326 PEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQN 385
Query: 367 KMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPG 419
KM ++NLA VFG NL+W +L A+ P+N FT+ L+++ ++F +P+ G
Sbjct: 386 KMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSG 438
>gi|56119110 family with sequence similarity 13, member A1 isoform a
[Homo sapiens]
Length = 1023
Score = 105 bits (261), Expect = 1e-22
Identities = 65/200 (32%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 224 FGVSLQYLKDKNQGEL-IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK 282
FGVSLQ L+ + E IP V+ V YL + GL EGLFR + +V+ V +++ + G
Sbjct: 41 FGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGV 100
Query: 283 PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI-TCVESSLRVTGCRQILRSL 341
PV GD+ A +LK FLRELP L+T + + + + ++ + R +++ L
Sbjct: 101 PVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL 160
Query: 342 PEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFT 401
P+ +Y +L+YL FL V++ + N+MN NLA VFG N G+ + N
Sbjct: 161 PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIM 220
Query: 402 ELLIEYYEKIFSTPEAPGEH 421
++E Y +F +H
Sbjct: 221 AKILENYNTLFEVEYTENDH 240
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 104 bits (259), Expect = 2e-22
Identities = 60/186 (32%), Positives = 102/186 (54%), Gaps = 6/186 (3%)
Query: 233 DKNQGELIPPVL-RFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGD 291
+K G + P+L V ++R++GL+ EGLFR V+E+Q ++ G+ +FD D
Sbjct: 49 EKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTD 108
Query: 292 IHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQI---LRSLPEHNYVV 348
+H A +LK +LRELP+P++ + YE L + S G +++ ++SLP NY +
Sbjct: 109 VHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNL 168
Query: 349 LRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP--SQGVSSLSALVPLNMFTELLIE 406
L+Y+ FL V S NKM+ NLA VFG N++ P ++ + V + ++I
Sbjct: 169 LKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIS 228
Query: 407 YYEKIF 412
++ +F
Sbjct: 229 KHDCLF 234
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 104 bits (259), Expect = 2e-22
Identities = 60/186 (32%), Positives = 102/186 (54%), Gaps = 6/186 (3%)
Query: 233 DKNQGELIPPVL-RFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGD 291
+K G + P+L V ++R++GL+ EGLFR V+E+Q ++ G+ +FD D
Sbjct: 51 EKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTD 110
Query: 292 IHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQI---LRSLPEHNYVV 348
+H A +LK +LRELP+P++ + YE L + S G +++ ++SLP NY +
Sbjct: 111 VHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNL 170
Query: 349 LRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP--SQGVSSLSALVPLNMFTELLIE 406
L+Y+ FL V S NKM+ NLA VFG N++ P ++ + V + ++I
Sbjct: 171 LKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIS 230
Query: 407 YYEKIF 412
++ +F
Sbjct: 231 KHDCLF 236
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 104 bits (259), Expect = 2e-22
Identities = 60/186 (32%), Positives = 102/186 (54%), Gaps = 6/186 (3%)
Query: 233 DKNQGELIPPVL-RFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGD 291
+K G + P+L V ++R++GL+ EGLFR V+E+Q ++ G+ +FD D
Sbjct: 144 EKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTD 203
Query: 292 IHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQI---LRSLPEHNYVV 348
+H A +LK +LRELP+P++ + YE L + S G +++ ++SLP NY +
Sbjct: 204 VHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNL 263
Query: 349 LRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP--SQGVSSLSALVPLNMFTELLIE 406
L+Y+ FL V S NKM+ NLA VFG N++ P ++ + V + ++I
Sbjct: 264 LKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIS 323
Query: 407 YYEKIF 412
++ +F
Sbjct: 324 KHDCLF 329
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 103 bits (256), Expect = 4e-22
Identities = 62/186 (33%), Positives = 98/186 (52%), Gaps = 5/186 (2%)
Query: 239 LIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVI 298
L P ++ V ++RE+GL EGLFR VR++Q ++ G+ FD D+H A +
Sbjct: 171 LAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASL 230
Query: 299 LKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILR---SLPEHNYVVLRYLMGF 355
LK +LRELP+P++ F YE L + + G ++ + +LP+ NY +LRY+ F
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKF 290
Query: 356 LHAVSRESIFNKMNSSNLACVFGLNLIWP--SQGVSSLSALVPLNMFTELLIEYYEKIFS 413
L V S NKM+ NLA VFG N++ P V+ + + +LI + ++F+
Sbjct: 291 LDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFT 350
Query: 414 TPEAPG 419
P G
Sbjct: 351 APVPEG 356
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 95.9 bits (237), Expect = 7e-20
Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 21/262 (8%)
Query: 172 YLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGR------TPPPTKTPPP---RPPLPTQ 222
Y ++ E++ L+ + ++D Q+L EG T PP P P R P P
Sbjct: 439 YFTKFKEYVNGSNLITKLQA-KHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLS 497
Query: 223 QFGVSL------QYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQR 276
+ L ++KD G+ IP V+ + Y+ GL+ +G+FR S V +I+
Sbjct: 498 VYSHKLFNGSMEAFIKDS--GQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKN 555
Query: 277 LYNQGKPVNFDDYG--DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTG 333
+ +G+ DD DI+ A +LK + R L PL + ++ ++ +E+ RV
Sbjct: 556 SFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQ 615
Query: 334 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA 393
+QIL +LP VV+RYL FL+ +S+ S N M+ NLA FG L+ G +S
Sbjct: 616 IQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC 675
Query: 394 LVPLNMFTELLIEYYEKIFSTP 415
+N + +I ++E IF +P
Sbjct: 676 QAHINEVIKTIIIHHEAIFPSP 697
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 94.7 bits (234), Expect = 2e-19
Identities = 57/213 (26%), Positives = 113/213 (53%), Gaps = 5/213 (2%)
Query: 208 PPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSAS 267
P KT + + Q FG L + ++ + +P ++ + + ++GL +G++R S +
Sbjct: 263 PSLKTLQEKGLIKDQIFGSHLHKVCER-ENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGN 321
Query: 268 VQTVREIQRLYNQGKPVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAYEQIL-GITC 324
+ T+++++ + NQ + +N DD + DIH+ LK F RELP+PL + +EQ + I
Sbjct: 322 LATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKK 381
Query: 325 VESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP 384
+++ R+ + +++ LP N ++ L G L + ++ N M++ +L VFG L+
Sbjct: 382 QDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRA 441
Query: 385 SQGVSSLSA-LVPLNMFTELLIEYYEKIFSTPE 416
+++ +V N EL++ Y KIF + E
Sbjct: 442 ENETGNMAIHMVYQNQIAELMLSEYSKIFGSEE 474
>gi|51479148 Rho GTPase activating protein 20 [Homo sapiens]
Length = 1191
Score = 94.7 bits (234), Expect = 2e-19
Identities = 57/171 (33%), Positives = 95/171 (55%), Gaps = 5/171 (2%)
Query: 215 PRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREI 274
P P+P Q FG+SL + + + L PVL + +L +KG T+G+FR+SA+V++ RE+
Sbjct: 354 PTSPMPGQLFGISLPNICENDN--LPKPVLDM-LFFLNQKGPLTKGIFRQSANVKSCREL 410
Query: 275 QRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCV-ESSLRVTG 333
+ N G V+ D I + A +LK FLR +P + + Y+ + + ++
Sbjct: 411 KEKLNSGVEVHLD-CESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINT 469
Query: 334 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWP 384
+++L LP N V+LRYL G LH + + S N+M + NLA +++WP
Sbjct: 470 VQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWP 520
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 92.4 bits (228), Expect = 8e-19
Identities = 58/203 (28%), Positives = 103/203 (50%), Gaps = 6/203 (2%)
Query: 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK- 282
FGV L+ + + + +P ++ + +GL + G++R + V +Q N+G
Sbjct: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
Query: 283 PVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILR 339
+N D + D+++ + +LK+F R+LP+PL T Y + +E + R+ R+++R
Sbjct: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
Query: 340 SLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQG--VSSLSALVPL 397
LP H Y L++L+G L ++ S NKM NLA VFG L+ S+ ++ +
Sbjct: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDR 988
Query: 398 NMFTELLIEYYEKIFSTPEAPGE 420
E LI++ + FS E GE
Sbjct: 989 YKIVETLIQHSDWFFSDEEDKGE 1011
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 91.3 bits (225), Expect = 2e-18
Identities = 61/183 (33%), Positives = 95/183 (51%), Gaps = 10/183 (5%)
Query: 206 TPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRS 265
+P T T PR +GVSL + E+ P+ V L +G++ EGLFR +
Sbjct: 262 SPSMTATHFPRV------YGVSLATHLQELGREIALPI-EACVMMLLSEGMKEEGLFRLA 314
Query: 266 ASVQTVREIQRLYNQGKPVNFDDY-GDIHIPAVILKTFLRELPQPLLTFQAYEQILGITC 324
A ++ +++ P + +++ D H A LK++LRELP+PL+TF Y+ +
Sbjct: 315 AGASVLKRLKQTM-ASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAAS 373
Query: 325 V-ESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIW 383
+ E R+ +++ LP N LRYLM FL ++ E NKM SN+A V G NL+W
Sbjct: 374 LKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLW 433
Query: 384 PSQ 386
P +
Sbjct: 434 PPE 436
>gi|21314774 T-cell activation Rho GTPase-activating protein isoform
b [Homo sapiens]
Length = 731
Score = 90.9 bits (224), Expect = 2e-18
Identities = 55/172 (31%), Positives = 97/172 (56%), Gaps = 3/172 (1%)
Query: 238 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAV 297
+ +P ++ +T L KG TEG+FRR+A+ + +E++ N G V+ + +H+ AV
Sbjct: 98 DTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAV 156
Query: 298 ILKTFLRELPQPLLTFQAYEQILG-ITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFL 356
+ K FLR +P+ LL+ +E+ +G + + R+ +Q+ LP N ++L++L+ L
Sbjct: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
Query: 357 HAVSRESIFNKMNSSNLACVFGLNLIWPSQGVS-SLSALVPLNMFTELLIEY 407
H +S+ S N+M+SSNLA G N++ S S A LN + L+E+
Sbjct: 217 HLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEF 268
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
Length = 1085
Score = 89.4 bits (220), Expect = 6e-18
Identities = 71/259 (27%), Positives = 125/259 (48%), Gaps = 21/259 (8%)
Query: 172 YLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGR------TPPPTKTPPP---RPPLPTQ 222
Y +L E+L+ L+ + ++D ++L EG T PP P P R P
Sbjct: 439 YFMKLREYLEGSNLITKLQA-KHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRS 497
Query: 223 QFGVSL------QYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQR 276
Q+ L ++KD G++IP ++ + ++ GL+ +G+FR S S V +I+
Sbjct: 498 QYNTKLFNGDLETFVKDS--GQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKN 555
Query: 277 LYNQGKPVNFDDYG--DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTG 333
+ +G+ DD DI+ A +LK + R L PL + + ++ +++ R
Sbjct: 556 SFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALH 615
Query: 334 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA 393
R++L +LP +V+RYL FL+ +S+ S N M+ NLA FG L+ + +S
Sbjct: 616 IRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSC 675
Query: 394 LVPLNMFTELLIEYYEKIF 412
+N + +I ++E IF
Sbjct: 676 QAHVNEIIKTIIIHHETIF 694
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 89.4 bits (220), Expect = 6e-18
Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 2/161 (1%)
Query: 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKP 283
FG L+ ++ E+ P+ V L E G++ EGLFR A +++++ +
Sbjct: 250 FGTPLEEHLKRSGREIALPI-EACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTS 308
Query: 284 VNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESS-LRVTGCRQILRSLP 342
+ Y D H A LK++LRELP+PL+TF YE+ + V+ ++ + + LP
Sbjct: 309 HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLP 368
Query: 343 EHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIW 383
N+V RYL+ FL +++ S NKM SN+A V G NL+W
Sbjct: 369 PQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLW 409
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 89.4 bits (220), Expect = 6e-18
Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 2/161 (1%)
Query: 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKP 283
FG L+ ++ E+ P+ V L E G++ EGLFR A +++++ +
Sbjct: 250 FGTPLEEHLKRSGREIALPI-EACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTS 308
Query: 284 VNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESS-LRVTGCRQILRSLP 342
+ Y D H A LK++LRELP+PL+TF YE+ + V+ ++ + + LP
Sbjct: 309 HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLP 368
Query: 343 EHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIW 383
N+V RYL+ FL +++ S NKM SN+A V G NL+W
Sbjct: 369 PQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLW 409
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 89.0 bits (219), Expect = 8e-18
Identities = 58/187 (31%), Positives = 99/187 (52%), Gaps = 3/187 (1%)
Query: 232 KDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYG- 290
++++ G+ IP V+ + Y+ GL+ +G+FR S V +I+ + +G+ DD
Sbjct: 487 RNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNE 546
Query: 291 -DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVV 348
DI+ A +LK + R L PL + ++ ++ +E+ RV +QIL +LP VV
Sbjct: 547 RDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVV 606
Query: 349 LRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYY 408
+RYL FL+ +S+ S N M+ NLA FG L+ G +S +N + +I ++
Sbjct: 607 MRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHH 666
Query: 409 EKIFSTP 415
E IF +P
Sbjct: 667 EAIFPSP 673
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 88.6 bits (218), Expect = 1e-17
Identities = 54/163 (33%), Positives = 91/163 (55%), Gaps = 5/163 (3%)
Query: 217 PPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREI-Q 275
P L ++QFGV L L +++ +P V+ + Y+ GL TEG++R+S S ++E+ Q
Sbjct: 2054 PELSSRQFGVELSRLTSEDR--TVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQ 2111
Query: 276 RLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQIL-GITCVESSLRVTGC 334
L + VN DDY +IH+ A + K +LR+LP PL+TF+ YE+ L + E + G
Sbjct: 2112 GLDTDAESVNLDDY-NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGV 2170
Query: 335 RQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVF 377
++ L + L L+ L ++ + N+M+++ LA VF
Sbjct: 2171 YSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVF 2213
>gi|20270373 T-cell activation Rho GTPase-activating protein isoform
c [Homo sapiens]
Length = 266
Score = 88.2 bits (217), Expect = 1e-17
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 238 ELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAV 297
+ +P ++ +T L KG TEG+FRR+A+ + +E++ N G V+ + +H+ AV
Sbjct: 98 DTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERL-PVHLLAV 156
Query: 298 ILKTFLRELPQPLLTFQAYEQILG-ITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFL 356
+ K FLR +P+ LL+ +E+ +G + + R+ +Q+ LP N ++L++L+ L
Sbjct: 157 VFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVL 216
Query: 357 HAVSRESIFNKMNSSNLACVFGLNLI 382
H +S+ S N+M+SSNLA G N++
Sbjct: 217 HLISKNSEVNRMDSSNLAICIGPNML 242
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 87.4 bits (215), Expect = 2e-17
Identities = 53/194 (27%), Positives = 96/194 (49%), Gaps = 4/194 (2%)
Query: 222 QQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQG 281
Q FG +L L + G +P ++ + ++ E GL +G++R S ++ +++++ N
Sbjct: 652 QVFGSNLANLCQRENGT-VPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHD 710
Query: 282 KPVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILR 339
+ ++ +D + DIH+ LK F RELP+PL TF + + E RV + ++R
Sbjct: 711 EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIR 770
Query: 340 SLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA-LVPLN 398
LP+ N ++ L L V N+M ++A VFG L+ P + +++ V N
Sbjct: 771 QLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQN 830
Query: 399 MFTELLIEYYEKIF 412
EL++ IF
Sbjct: 831 QIVELILLELSSIF 844
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/204 (27%), Positives = 98/204 (48%), Gaps = 6/204 (2%)
Query: 216 RPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQ 275
+ P T FGV L + IP ++ + E+GL G++R + + +Q
Sbjct: 1137 KKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQ 1196
Query: 276 RLYNQGKP---VNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RV 331
N+G + D + D+++ + +LK+F R+LP+PL T Y + E L R+
Sbjct: 1197 EELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRL 1256
Query: 332 TGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQG--VS 389
++++ LPEH+Y L++L L V+ S NKM NLA VFG L+ S+
Sbjct: 1257 KTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTH 1316
Query: 390 SLSALVPLNMFTELLIEYYEKIFS 413
++ + E LI++++ F+
Sbjct: 1317 MVTHMPDQYKIVETLIQHHDWFFT 1340
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 87.0 bits (214), Expect = 3e-17
Identities = 71/245 (28%), Positives = 118/245 (48%), Gaps = 31/245 (12%)
Query: 193 RYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLR 252
R KL+ L R PP ++ R L Q FG L+ L + +G+ +P LR + +
Sbjct: 492 RVRNKLKRLIAKR--PPLQSLQERGLLRDQVFGCQLESLCQR-EGDTVPSFLRLCIAAVD 548
Query: 253 EKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFD--------------------DYGDI 292
++GL +G++R S ++ V++++ L ++ + V D ++ DI
Sbjct: 549 KRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDI 608
Query: 293 HIPAVILKTFLRELPQPL---LTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVL 349
H+ LK FLRELPQPL L + L ++ ES ++ ++++ S+P+ N+ L
Sbjct: 609 HVVTGALKLFLRELPQPLVPPLLLPHFRAALALS--ESEQCLSQIQELIGSMPKPNHDTL 666
Query: 350 RYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVS--SLSALVPLNMFTELLIEY 407
RYL+ L V S N+M NL VFG L P Q S + AL P +L++
Sbjct: 667 RYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYP-GQLVQLMLTN 725
Query: 408 YEKIF 412
+ +F
Sbjct: 726 FTSLF 730
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 87.0 bits (214), Expect = 3e-17
Identities = 71/245 (28%), Positives = 118/245 (48%), Gaps = 31/245 (12%)
Query: 193 RYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLR 252
R KL+ L R PP ++ R L Q FG L+ L + +G+ +P LR + +
Sbjct: 308 RVRNKLKRLIAKR--PPLQSLQERGLLRDQVFGCQLESLCQR-EGDTVPSFLRLCIAAVD 364
Query: 253 EKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFD--------------------DYGDI 292
++GL +G++R S ++ V++++ L ++ + V D ++ DI
Sbjct: 365 KRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDI 424
Query: 293 HIPAVILKTFLRELPQPL---LTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVL 349
H+ LK FLRELPQPL L + L ++ ES ++ ++++ S+P+ N+ L
Sbjct: 425 HVVTGALKLFLRELPQPLVPPLLLPHFRAALALS--ESEQCLSQIQELIGSMPKPNHDTL 482
Query: 350 RYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVS--SLSALVPLNMFTELLIEY 407
RYL+ L V S N+M NL VFG L P Q S + AL P +L++
Sbjct: 483 RYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYP-GQLVQLMLTN 541
Query: 408 YEKIF 412
+ +F
Sbjct: 542 FTSLF 546
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/195 (28%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
Query: 222 QQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQG 281
Q FG +L L ++ + +P ++ + + +GL +GL+R S ++ T+++++ +
Sbjct: 325 QVFGCALAALCERERSR-VPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD 383
Query: 282 KPVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGC-RQIL 338
+ ++ DD + D+H+ LK F RELP+PL F + Q + ++ R + C R ++
Sbjct: 384 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 443
Query: 339 RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSL-SALVPL 397
RSLP N+ LR L L V N+M+ ++A VFG L+ P +S+ +V
Sbjct: 444 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQ 503
Query: 398 NMFTELLIEYYEKIF 412
N EL+++ IF
Sbjct: 504 NQVVELILQQCADIF 518
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/195 (28%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
Query: 222 QQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQG 281
Q FG +L L ++ + +P ++ + + +GL +GL+R S ++ T+++++ +
Sbjct: 352 QVFGCALAALCERERSR-VPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD 410
Query: 282 KPVNFDD--YGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGC-RQIL 338
+ ++ DD + D+H+ LK F RELP+PL F + Q + ++ R + C R ++
Sbjct: 411 ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLV 470
Query: 339 RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSL-SALVPL 397
RSLP N+ LR L L V N+M+ ++A VFG L+ P +S+ +V
Sbjct: 471 RSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQ 530
Query: 398 NMFTELLIEYYEKIF 412
N EL+++ IF
Sbjct: 531 NQVVELILQQCADIF 545
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 85.1 bits (209), Expect = 1e-16
Identities = 47/147 (31%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 239 LIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVI 298
L+P ++ ++ E G EG+FR V++++ ++ G+ +FD D+H A +
Sbjct: 175 LVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASL 234
Query: 299 LKTFLRELPQPLLTFQAYEQIL---GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGF 355
LK +LR+LP+P++ + YE L +T + + + L LP NY +L Y+ F
Sbjct: 235 LKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRF 294
Query: 356 LHAVSRESIFNKMNSSNLACVFGLNLI 382
LH + NKM+ NLA V G+NLI
Sbjct: 295 LHEIQLNCAVNKMSVDNLATVIGVNLI 321
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 85.1 bits (209), Expect = 1e-16
Identities = 47/147 (31%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 239 LIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVI 298
L+P ++ ++ E G EG+FR V++++ ++ G+ +FD D+H A +
Sbjct: 168 LVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASL 227
Query: 299 LKTFLRELPQPLLTFQAYEQIL---GITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGF 355
LK +LR+LP+P++ + YE L +T + + + L LP NY +L Y+ F
Sbjct: 228 LKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRF 287
Query: 356 LHAVSRESIFNKMNSSNLACVFGLNLI 382
LH + NKM+ NLA V G+NLI
Sbjct: 288 LHEIQLNCAVNKMSVDNLATVIGVNLI 314
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 83.2 bits (204), Expect = 5e-16
Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 33/270 (12%)
Query: 216 RPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQ 275
R P T FGV L ++ E +P V+ + + L +G++R S S V +
Sbjct: 541 RLPARTPLFGVDFLQLP-RDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLC 599
Query: 276 RLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI------------- 322
+ + G+ + H + +LK FL+EL +P++ F Y+ + +
Sbjct: 600 QAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPG 659
Query: 323 TCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLI 382
T S + + +L LP+ NY LR+L+ L V+ + NKM+++NL VFG L+
Sbjct: 660 TPSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLL 719
Query: 383 WPSQGVSSLSALVPLN---------MFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAA 433
P G + SA +P+ E LI +YE+IF E P P Q S A
Sbjct: 720 RPPDGPRAASA-IPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELP--QATEPPPQDSSPA 776
Query: 434 PLQEAVPRTQATGLTKPTLPPS---PLMAA 460
P P T ++ P L P P++A+
Sbjct: 777 P----GPLTTSSQPPPPHLDPDSQPPVLAS 802
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,885,483
Number of Sequences: 37866
Number of extensions: 998689
Number of successful extensions: 7476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 6814
Number of HSP's gapped (non-prelim): 538
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.