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Search of human proteins with 64085252
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
(1094 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 2125 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 159 1e-38
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 154 4e-37
gi|71061468 centromere protein E [Homo sapiens] 153 1e-36
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 152 2e-36
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 150 5e-36
gi|148746195 trichohyalin [Homo sapiens] 150 8e-36
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 150 8e-36
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 150 8e-36
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 150 8e-36
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 150 8e-36
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 147 4e-35
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 145 2e-34
gi|55770834 centromere protein F [Homo sapiens] 144 5e-34
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 142 1e-33
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 141 3e-33
gi|156104908 myosin heavy chain 6 [Homo sapiens] 141 3e-33
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 139 2e-32
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 139 2e-32
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 139 2e-32
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 139 2e-32
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 138 3e-32
gi|58530840 desmoplakin isoform I [Homo sapiens] 137 4e-32
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 137 6e-32
gi|21735548 centrosomal protein 2 [Homo sapiens] 137 7e-32
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 137 7e-32
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 137 7e-32
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 137 7e-32
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 137 7e-32
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 137 7e-32
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 2125 bits (5507), Expect = 0.0
Identities = 1094/1094 (100%), Positives = 1094/1094 (100%)
Query: 1 MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQ 60
MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQ
Sbjct: 1 MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQ 60
Query: 61 MLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGS 120
MLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGS
Sbjct: 61 MLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGS 120
Query: 121 ELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGD 180
ELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGD
Sbjct: 121 ELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGD 180
Query: 181 DFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVER 240
DFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVER
Sbjct: 181 DFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVER 240
Query: 241 RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEG 300
RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEG
Sbjct: 241 RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEG 300
Query: 301 SRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQD 360
SRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQD
Sbjct: 301 SRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQD 360
Query: 361 LEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQML 420
LEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQML
Sbjct: 361 LEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQML 420
Query: 421 DRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE 480
DRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE
Sbjct: 421 DRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE 480
Query: 481 DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 540
DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE
Sbjct: 481 DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 540
Query: 541 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK 600
NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK
Sbjct: 541 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK 600
Query: 601 IQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKA 660
IQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKA
Sbjct: 601 IQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKA 660
Query: 661 VLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMK 720
VLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMK
Sbjct: 661 VLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMK 720
Query: 721 HFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKL 780
HFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKL
Sbjct: 721 HFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKL 780
Query: 781 KYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACK 840
KYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACK
Sbjct: 781 KYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACK 840
Query: 841 TFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQ 900
TFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQ
Sbjct: 841 TFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQ 900
Query: 901 QLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET 960
QLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET
Sbjct: 901 QLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET 960
Query: 961 STQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRT 1020
STQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRT
Sbjct: 961 STQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRT 1020
Query: 1021 KSFKGDRTFLEGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATM 1080
KSFKGDRTFLEGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATM
Sbjct: 1021 KSFKGDRTFLEGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATM 1080
Query: 1081 NGTSSQPKKEEYGS 1094
NGTSSQPKKEEYGS
Sbjct: 1081 NGTSSQPKKEEYGS 1094
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 159 bits (402), Expect = 1e-38
Identities = 208/1003 (20%), Positives = 437/1003 (43%), Gaps = 116/1003 (11%)
Query: 152 VQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEEL----TEKL 207
+Q T +L + L + +Q ++ + E+ R+ + E K L E TE
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELE-EMERKHQQLLEEKNILAEQLQAETELF 903
Query: 208 NEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHE 267
EA++ ++ L+E+ ++ + E E R L ++Q ++ E + DE E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 268 GAIKNKLR----QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDR 323
GA + KL+ E + ++E+E+ L ++ ++ + ++ E +QL + E
Sbjct: 964 GA-RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 324 KGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEE 383
K L ++ S+ ++ ++ + R+ +E+ K+ L+ + +DL+ Q+ + + ++++E
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI--AELQAQIDE 1080
Query: 384 VKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQ 443
+K + +K++E ++ ++ T N K ++ ++ E+Q F++ +A R A+ Q
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 444 ISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLER- 502
+L+ E + E L + L+ + E+ +LK +E + + + + + +
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200
Query: 503 ---ALEKQSETVDELTGKNNQILKEKDELKT---QLYAALQQIENLRKELNDVLTKRALQ 556
ALE+ SE +++ + K K L+T +L ++ ++ ++ E K Q
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQ--------SKIQSQMKVE 608
+ELH+K + ++ A+ +++N LD + L E +K+ + ++SQ++
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 609 K-----------------AHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKL 651
+ LEEE L++ Q +++ +++ + L + AD K+
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 652 AEE-------ERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSL 704
++ E AKK +LKD L+ R EE A +L+ ++ Q+EL DLT L
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALS----QRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 705 QSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRL 764
H++ + ++ +K+ + +++ A EE++ A+ + E R
Sbjct: 1437 D-----HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 765 TEELTQN----ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCL 820
EE + E +NK+L+ + L ++ K++ E+ R +E+ +++ QL L
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 821 ETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHY--DPHRWLAESKTKLQWLC 878
E E ++ ++D+ +L+V + D +++ K + L
Sbjct: 1552 EDELQA----------------TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 879 EELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDL- 937
++++E E ++ R Q L + + E +L+ L QIE + DE+ ++ R L
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKM----EIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 938 --LEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERT 995
+++ QR+ EE + +D + A ++ L LE+ E L L E+ +SSE
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA--EILQLQEEL-------ASSE-- 1700
Query: 996 DGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLE-----GSHTRGLDHSSSWQDHSRF 1050
R RR++ Q + T S G L+ + L+ + +
Sbjct: 1701 -------RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Query: 1051 LSSPRFS----YVNSFTKRTVAPDSASNKEDATMNGTSSQPKK 1089
L + RF V++ A SA+ K D Q K+
Sbjct: 1754 LLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Score = 155 bits (392), Expect = 2e-37
Identities = 197/909 (21%), Positives = 400/909 (44%), Gaps = 113/909 (12%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELT-------EKLNEAQKQEVVSDRV 220
+R+L ++ L +DF E + R++++ + + EEL + L+ Q+ + +
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 221 ERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETE 280
E+ + EL++ + E + E + + E L +Q +A + ++ + ET+
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 281 KNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNY 340
+L E+++ +++ +SE R+ L QV+EL ++++ + R L + S++ + N
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN- 1291
Query: 341 QDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLAS 400
V ++ EK+ ++ + +++ S+L++ + ++ + ++K +L+S
Sbjct: 1292 -------------VSTLLEEAEKK--GIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 401 QVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAER 460
++ L E + ++QQ + E RK+ + Q+ L D K+ +
Sbjct: 1337 RIRQLEEEKNSLQEQQ--------------EEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 461 YLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELT----- 515
L ++ E K++ K E L + +E L + KLE+ + + +D+LT
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEK----ALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 516 ------------GKNNQILKEKDELKTQLYAALQ---QIENLRKELNDVLTKRALQEEEL 560
K +Q+L E+ + + YA + + E KE + RAL EE L
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISAR-YAEERDRAEAEAREKETKALSLARAL-EEAL 1496
Query: 561 HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEEIAEL 619
+KEE R K +AD+E ++ +S D + + EL+K + ++ Q++ + LEE EL
Sbjct: 1497 EAKEEFERQNKQLRADME-DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 620 KKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK-SRDE 677
QA + AK L ++ +++ + A DL + + E K+ ++K + +L A+ + R +
Sbjct: 1556 ---QATEDAK-LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQEL------MKHFKKEKSEAEN 731
+ ++ K+E D LKDL + +++ ++ I++L MK +++E EA
Sbjct: 1612 RALAVASKKKMEID-----LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEE 791
+ A+S E + +L+ L+++ +L EEL +E + + + L D++
Sbjct: 1667 SRDEIFAQSKESEK-------KLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 792 REKHISIEEEHLRRMEEARLQLKDQLLCLETEQES--ILGVIGKEIDAACKTFSKDSVEK 849
S + RR+E QL+++ LE EQ + +L ++ T + + +
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEE---LEEEQSNMELLNDRFRKTTLQVDTLNAELAAE 1776
Query: 850 LKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKER--------ENREKNLRHQL---MLC 898
+ R E K KLQ L +K + E + L QL
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 899 RQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDL---LEETQRKDEEMGSLQDRV 955
R L E +L+ +F Q+E + + D+ + +++ +R+ EE R
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896
Query: 956 IALETSTQVALDHL----ESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQH 1011
A Q LD E + ++S L++ S S GR + + SL+
Sbjct: 1897 NASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGR-RQLHLEGASLEL 1955
Query: 1012 HQDDTKYRT 1020
DDT+ +T
Sbjct: 1956 SDDDTESKT 1964
Score = 46.2 bits (108), Expect = 2e-04
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 19/198 (9%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
+ L + S L D F + + +AE + N Q+ E + ++ +LQ
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 226 ELEREMRTE-RELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKL-RQTETEKNQ 283
ELE ++++ + + + ++G QL+E L +QEAK E A NKL R+TE + +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIG----QLEEQL-EQEAK----ERAAANKLVRRTEKKLKE 1853
Query: 284 LEQELELSRRLLNQSEGSRE-------TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQ 336
+ ++E RR +Q + E L Q+EE + T+A R+ LQ ++ ++
Sbjct: 1854 IFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEA 1913
Query: 337 QSNYQDEQGE-DWRFRRG 353
E R RRG
Sbjct: 1914 NEGLSREVSTLKNRLRRG 1931
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 154 bits (389), Expect = 4e-37
Identities = 183/923 (19%), Positives = 385/923 (41%), Gaps = 126/923 (13%)
Query: 150 RFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE 209
R VQE + Q+ Q+L+D Q L F ++ S R+ + E E
Sbjct: 216 RVVQEENQHMQMT--IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
Query: 210 AQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA 269
++Q + + L+E+E + T+++ + R + + + LQ +A ++HE
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERT 333
Query: 270 ------------IKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELR-TQL 316
+++ L Q E E + L +E+ RR N + ++ L V E++ +++
Sbjct: 334 RRLAEAEMHVHHLESLLEQKEKENSMLREEMH--RRFENAPDSAKTKALQTVIEMKDSKI 391
Query: 317 TKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWR-----------FRRGVEREKQDL---E 362
+ E + L+ ++ + + +E+ E+ + + VE+ K++L E
Sbjct: 392 SSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKE 451
Query: 363 KQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQML-- 420
Q +L+ + + + +E+ +VK+ + RKD E L +++E LT + + KQ +++L
Sbjct: 452 AQWEELKKKA--AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS-KQHIEVLKE 508
Query: 421 ------DRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEE 474
R +Q D + + +++ T+ +D ++ E+ + + +
Sbjct: 509 SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 568
Query: 475 AEKRREDLKLKAQESIRQWKLKHKKL----ERALEKQSETV----------DELTGKNNQ 520
E++ L+ K + Q + K K++ ER Q++T + L K
Sbjct: 569 KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 628
Query: 521 ILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADL--- 577
I + K++ ++I+N +K+L D+ K +L + +L KE L D+K H + L
Sbjct: 629 IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688
Query: 578 -----------ELEVKNSLDTIHRLESELKK------QSKIQSQMKVEKAHLEEEIAELK 620
E+ ++ + ++ES+LKK +++ +M HLE EI K
Sbjct: 689 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748
Query: 621 KSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETA 680
++ +A++ + E +K++ + D K+AE ER K K +++L + + +++A
Sbjct: 749 DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 808
Query: 681 TIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
++ + + D L D + LQ K + I+EL + ++ L E
Sbjct: 809 QMLEEARRRED----NLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEE 864
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHI-SIE 799
N K Q+E+L +++ +EL + +K K + L E+E H+ ++
Sbjct: 865 SARTNAEK----QVEELLMAMEKVKQEL-------ESMKAKLSSTQQSLAEKETHLTNLR 913
Query: 800 EEHLRRMEEARLQLKDQLLCLETEQESILGV----------------IGKEIDAACKTFS 843
E + +EE ++ LL +E+++ + + + +E D +
Sbjct: 914 AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 973
Query: 844 KDSVEKLKVFSSG-PDIHY-DPHRWLAESKTKLQWLCEELKERENREKNLR----HQLML 897
+ + ++K+ + D H+ H K + + L E + L+ H L
Sbjct: 974 QQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTL 1033
Query: 898 CRQQ----LRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQD 953
C + LR LT L Q + +L + +D LE+ +R + E+ +
Sbjct: 1034 CHDRDPLILRGLTPPASYNLD--DDQAAWENELQKMTRGQLQDELEKGERDNAELQEFAN 1091
Query: 954 RVIALETSTQVALDHLESVPEKL 976
++ Q DH + E++
Sbjct: 1092 AIL------QQIADHCPDILEQV 1108
Score = 87.4 bits (215), Expect = 7e-17
Identities = 113/579 (19%), Positives = 257/579 (44%), Gaps = 69/579 (11%)
Query: 449 RHAEDAT-KQAERYLSE-LQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
R A D T + L E L++++ L+++ E + L + SI+ + K ERAL K
Sbjct: 144 RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS-SSMNSIKTFWSPELKKERALRK 202
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRA-----------L 555
+ + + ++++E+++ ALQ ++++LN + + + L
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
Query: 556 QEEE---LHSKEEK----LRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVE 608
EE LH++ E+ L ++ ++EL ++ T++ + +KK ++ +
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
Query: 609 KAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL 668
EE+ ++ L E + + L ++ L K E ++ + + +
Sbjct: 323 AKATEEDHERTRR--------LAEAEMHVHHLESL---LEQKEKENSMLREEMHRRFENA 371
Query: 669 TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHF 722
AK++ +T + K+ +R L+DL +Q +K T+ + + M+ +
Sbjct: 372 PDSAKTKALQTVIEMKDSKISS--MERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
Query: 723 KKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+ +N + LK E ++ + + + L+++ ++ +EL++ + E L+ K
Sbjct: 430 RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
Query: 783 QCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLE---TEQESILGVIGKEID--A 837
+ L +Q + ++HI + +E L E+ L+ ++ L E+E++L K+I A
Sbjct: 490 ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMA 549
Query: 838 ACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLML 897
K + LK D+ R + + K++ L E+L+++E + +L+ ++
Sbjct: 550 EEKGTQAGEIHDLK------DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV-- 601
Query: 898 CRQQLRNLTENKESELQCLFQQIERQEQLLDEI----HREKRDLLEETQRKDEEMGSLQD 953
+ L+ T N ++ L L + + +E+ ++ + R++R+ EE +++ L++
Sbjct: 602 --KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 659
Query: 954 RVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSS 992
+V L+ + EK + L D K+ S +SS
Sbjct: 660 KVSLLQ----------GDLSEKEASLLDLKEHASSLASS 688
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 153 bits (386), Expect = 1e-36
Identities = 217/1047 (20%), Positives = 456/1047 (43%), Gaps = 140/1047 (13%)
Query: 34 TVEVTEKVNT-ITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQ-LR 91
T++ E+ T IT LQ T ++ + Q ++ + LK + +++ +
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 92 SQRLLRN---SGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKD--------YGDPQGI 140
+Q LRN S + + S + LH T KD Q +
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 141 KRMRSRTGVRFVQETDDMTQL----------HGFHQSLRDLSSEQIRLGDDF--NRELSR 188
+ ++T V++ + + Q + Q L + +E+ +L D N E++
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081
Query: 189 RSRSDA-----ETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQD 243
++ + E K+ E + ++ N A K+E R RL E+E +++ + + ++ +Q
Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ 1141
Query: 244 QLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQE-LELSRRLLNQSEGSR 302
QL L +QE + + + K +E E +KN+L+ E +E E LEL+++L N++
Sbjct: 1142 QL----LNVQEEMSEMQKKINEIEN-LKNELKNKELTLEHMETERLELAQKL-NENYEEV 1195
Query: 303 ETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE-----------QGEDWRFR 351
+++ + + L+ E +R L+ + +I ++E Q R
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 352 RGVEREK------QDLEKQMSDLRVQLNFSAMASEL----EEVKRCMERKDKEKAHLASQ 401
R V + QDLEK + L+ ++ EL +EV E ++ +
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 402 VENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERY 461
+ L E ++L++ ++ +E Q + ER + L + +
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 462 LSELQQSEALKEEA--EKRREDLKLKAQESIRQWKLKHK---KLERALEKQSETVDELTG 516
L+++Q+S++ +E++ K +++ K + Q+K K ++E + S+ + E
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 517 KNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH-------SKEEKLRD 569
+ + KEKD+L+ + + L++ + +++ K EEEL +EE + +
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 570 IKSHQADLELEV---KNSLDTIH-RLESELKKQSKIQSQMKVEK-AHLEEEIAELKKSQA 624
++ + ++ E E+ + L+ I+ +L++++++ + + Q +++ + ++E++ ELK+ +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 625 QDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIIT 684
KAK +++ + + +L N+L E + + ++K+ EE +
Sbjct: 1556 HRKAK----DSALQSIESKMLELTNRLQESQEEIQIMIKE-----------KEEMKRVQE 1600
Query: 685 QLKLERDVHQRELKDLTSSLQSVKTKHEQ---------------NIQELMKHFKKEKSEA 729
L++ERD + K++ + ++ + K Q I+ L + F+ +K
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 730 EN------HIRTLKAESLEEKNMAKIHRGQL----EKLKSQCDRLTEEL----TQNENEN 775
EN + + E+LEE R L E LK + D+L E L T++ +
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720
Query: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLK---DQLLCLETEQESILGVIG 832
++LK+ + LK+ E +K I E + + L+ D L + + + L +
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 833 KEIDAACKTFSKDSVEKLK-VFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNL 891
+ +++++KL+ + S D + + L S KLQ +ELK E
Sbjct: 1781 MHLKE-----QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANE------ 1829
Query: 892 RHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSL 951
HQL+ ++ + N T+ K SE++ L +QI+ Q L ++ E +L ++ EEM S+
Sbjct: 1830 -HQLITLKKDV-NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSV 1887
Query: 952 ---QDRVIALETSTQVALDHL-ESVPE 974
+D + +E + ++ D L ES+ E
Sbjct: 1888 MKERDNLRRVEETLKLERDQLKESLQE 1914
Score = 133 bits (335), Expect = 8e-31
Identities = 203/982 (20%), Positives = 411/982 (41%), Gaps = 142/982 (14%)
Query: 153 QETDDMTQLH-GFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQ 211
QE + LH F Q + + E R+ + + D+ EL+ K E Q
Sbjct: 817 QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876
Query: 212 KQEVVSDRVERRLQELEREMRTERELVERRQDQLG-------LMSLQLQEALKKQEAKAD 264
++ R +QE EM +E +E R L L++ +LQ+ L++ +
Sbjct: 877 EKT-------REVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRK 324
E + +K + E++QL+ ++ + +N + ++E L + +E L+ +
Sbjct: 930 EKDD-LKQLQESLQIERDQLKSDIHDT---VNMNIDTQEQLRNALESLKQHQETINTLKS 985
Query: 325 GLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLE-----------KQMSDLRVQLN 373
+ +VS+ + N + + E + G+++ KQDLE K + Q
Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Query: 374 FSAMASELEEVKRCMERKDKEKAHLASQV-ENLTRELENGEKQQLQMLDRLKEIQNHFDT 432
++ E E+++ +E EK L + + EN+ +EN E+ +L + D LK+ Q +
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL-LGDELKKQQ---EI 1100
Query: 433 CEAERKHADLQISELTR------HAEDATKQAERYLSELQQS------------------ 468
E+ HA + EL+R E+ K+ + L E QQ
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 469 ----------EALKEEAEKRREDLKLKAQESIRQWK--LKHKKLERALEKQSETV-DELT 515
E E E R +L K E+ + K K +K+ + L+K ET D L
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 516 GKNNQI----LKEKDELKT---QLYAALQQIENLRKELNDVLTK-----------RALQE 557
G +I L+ K+ELK L + I+ LR+ +++ + LQE
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 558 E--ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLE----SELKKQSKIQSQMKVEKAH 611
E LH ++E L ++K EV + +T++ LE K S +++++E+
Sbjct: 1281 EIPVLHEEQELLPNVK--------EVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
Query: 612 LEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQ 671
L E+ E + + + K + ++IK+ ++ D + E AK + + +
Sbjct: 1333 LNEKFQE-SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Query: 672 AKSRDEETATIITQLK-------------LERDVHQRELKDLTSSLQSVKTKHEQNIQEL 718
K +D ET I+++++ +E + L++ ++SV K + ++Q L
Sbjct: 1392 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV-AKEKDDLQRL 1450
Query: 719 MKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKL 778
+ + E + + +I+ + A+ LE + K+ L++ + + L L++ E E +
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 779 KLKYQCLKDQLEEREKHISIEEE-----HLRRMEEARLQLKDQLLCLETEQESILGVIGK 833
+ + + + D+L+ + + I +EE + ++E +LK + + ++ + K
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 834 EIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL--KERENREKNL 891
++ + ++S E++++ + L + +L+ +E+ K +E++EK
Sbjct: 1571 MLELTNRL--QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEK-- 1626
Query: 892 RHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSL 951
+ + N T+ K E++ L +Q E Q+ L+ I E L + EEM S+
Sbjct: 1627 --EYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 952 ---QDRVIALETSTQVALDHL-----ESVPEKLSLLEDFKDFRDSCSSSERT-DGRYSKY 1002
+D + ++E + +V D L E++ L E+ K + T D
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 1003 RVRRNSLQHHQDDTKYRTKSFK 1024
+ N + + Q D ++ + K
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALK 1766
Score = 118 bits (295), Expect = 3e-26
Identities = 210/1052 (19%), Positives = 427/1052 (40%), Gaps = 143/1052 (13%)
Query: 41 VNTITSTLQDT--SRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRN 98
V + + TLQ ++ R+V LG+ + N ++ ++ +L S LLR
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKL-SINLLRE 460
Query: 99 SGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDM 158
S + + ++ LD T SE+ P T L + +R+ + D++
Sbjct: 461 IDESVCSESDVFSNTLD--TLSEIEWNPATKLLNQENIESELNSLRA--------DYDNL 510
Query: 159 TQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSD 218
L EQ+R + EL + ++D + ALE T+K E Q +S+
Sbjct: 511 V-----------LDYEQLRTEKE-EMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN 558
Query: 219 ------RVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
E Q+LE E+ ++ EL+ ++DQ+ +LQE + Q K + + +
Sbjct: 559 LKNLVKHAEVYNQDLENELSSKVELLREKEDQIK----KLQEYIDSQ--KLENIKMDLSY 612
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGS------RETLLHQVEELRTQLTKAEGDRKGL 326
L E K + + L+ S L +++EL T + E D +
Sbjct: 613 SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLY 672
Query: 327 QHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELE-EVK 385
Q Q+ K Q + + E F + K DL L ++L+ E+
Sbjct: 673 QSQLEAKKKMQVDLEKELQS--AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN 730
Query: 386 RCMERKD--KEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQ 443
+ +E + +E+ L S++++L E+E K+ + L I + D +E H + +
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 444 IS----ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKK 499
+ E+ + +D Y S Q+ + K + K+ +E+
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN---------- 840
Query: 500 LERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEE 559
E+ ++ + L+ + + LKT+L Q+++ +E+ + L + +E+
Sbjct: 841 -----ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 560 LHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAEL 619
L +++ L+ ++ + + +++ +L+ + L E ++Q +++E+ L+ +I +
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 620 KKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEE------------------------- 654
+ +L ES+K L +K++EE
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 655 ERAKKAVLKDLSDLTAQAKSRD-EETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ 713
++ + K+ LTA K + E I L E++ Q+ L+ + + + +KT ++
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 714 NIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQL-----------EKLKSQCD 762
NI+ +++ ++E + ++ + +EKN A G+L EKLK +
Sbjct: 1076 NIEMTIEN-QEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 763 RLTEELTQ---------------NENENKKLKLKYQCLKDQLEEREK-----HISIEEEH 802
+L E+ Q NE EN K +LK + L + E E+ ++ E
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
Query: 803 LRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYD 862
++ + + R LK+ ETE++ + G I +EI+A + E+LK+ H +
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYI-REIEAT----GLQTKEELKIAHIHLKEHQE 1249
Query: 863 PHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKE--------SELQ 914
L S ++ ++ E L+ ++ + ++ L KE +EL+
Sbjct: 1250 TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE 1309
Query: 915 CLFQQ-IERQEQLLDEIHREKRDLLEETQRKDEEMGSL---QDRVIALETSTQVALDHL- 969
L +Q + L I E+ L E+ Q EE+ SL +D + ++ + +V D L
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 970 ESVPEKLSLLEDFKDFRDSCSSSERTDGRYSK 1001
E + E L+ +++ + ++ + + D +K
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Score = 105 bits (261), Expect = 3e-22
Identities = 209/998 (20%), Positives = 415/998 (41%), Gaps = 134/998 (13%)
Query: 76 IEHLKESLEQSIDQLRS---QRLLRNSGGRSISVTSLSASDLDGGTG---SELHHFPP-- 127
++ +KE+LE DQL+ + L + +S SL+ + D T SE+ F P
Sbjct: 1354 LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKD 1413
Query: 128 TSPLKDYGDPQGIKR--MRSRTGVRFV-QETDDMTQLHGFHQSLRDLSSEQIR--LGDDF 182
++ L+ + G+ + S ++ V +E DD+ +L QS D E I+ +
Sbjct: 1414 SALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHL 1473
Query: 183 NRE---------LSRRSRSDAETKRALEELTEKLNEAQKQ-EVVSDRVERRLQEL-EREM 231
E L + + E + L E +++ QKQ E ++D+++ ++QE+ E+E
Sbjct: 1474 ETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533
Query: 232 RTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA---IKNKLRQTETEKNQLEQEL 288
+ + + Q+++ + Q +E K +++ E + N+L++++ E + +E
Sbjct: 1534 QFNIKQISEVQEKVNELK-QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 289 ELSRRLLNQSEGSRETLLHQVEEL----------------RTQLTKAEGDRKGLQHQVSQ 332
E +R+ + R+ L +E+ T + + + ++H Q
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 333 ISKQQSNYQDEQGEDWRFR----------RGVEREKQDLEKQMSDLRVQLNFSAMASELE 382
Q+ N ++ + E+ R R V +E+ DL L+V+ + + E
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD-QLKENLRE 1711
Query: 383 EVKRCMERKDKEKA---HLASQVENL----------TRELENGEKQQLQMLDRLK----E 425
+ R +E++++ K HL E + T E+ N +K D LK +
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 426 IQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEA-LKEEAEKRRED--- 481
IQ K I +L + T + +L+ S A L+E+ ++ + +
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 482 -LKLKAQESIRQWKLKH-KKLERALEKQSETVDELTGKN--------------NQILKEK 525
+ LK + Q K+ ++L++ ++ QS T+ +L +N ++KE+
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER 1891
Query: 526 DEL----------KTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQ- 574
D L + QL +LQ+ + E+ L + +E +KLR+ S +
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKT 1951
Query: 575 ---ADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLL 631
+D++ ++ S D + + EL+K+ ++K + ++I E+++ + Q +A+ L
Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL 2011
Query: 632 EMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKS----RDEETATIITQLK 687
MQ D L KL E + V K+ +L +S RD+ AT+ +
Sbjct: 2012 SMQSVRMD----NFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIA 2067
Query: 688 LERDVHQ-RELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLE---- 742
+R HQ + K L S Q T+ + +K K SE ++H L SL+
Sbjct: 2068 RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 743 ---EKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKL-----KLKYQCLKDQLEEREK 794
+K ++ + L Q + + T N+ + + KLKY + E+
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187
Query: 795 HISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKD--SVEKLKV 852
H SI + + ++E Q K+ L+ ++ Q+ V +E+ + D E LK
Sbjct: 2188 HESINKFEMDFIDEVEKQ-KELLIKIQHLQQD-CDVPSRELRDLKLNQNMDLHIEEILKD 2245
Query: 853 FSSG--PDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKE 910
FS P I + + L+ K Q+L E L R + EK L++ + ++ +
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEK-LKNGIQKENDRICQVNNFFN 2304
Query: 911 SELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEM 948
+ + + + E+ I +E L+ + K+E++
Sbjct: 2305 NRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Score = 99.8 bits (247), Expect = 1e-20
Identities = 160/723 (22%), Positives = 307/723 (42%), Gaps = 93/723 (12%)
Query: 286 QELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSN--YQDE 343
++ +L+R L N G+ +T + +T D Q + +K N Y +E
Sbjct: 284 RDSKLTRILQNSLGGNAKT------RIICTITPVSFDETLTALQFASTAKYMKNTPYVNE 337
Query: 344 QGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVE 403
D + +E DL+KQ+ + V L A A E +++ + +E KD + ++E
Sbjct: 338 VSTDEALLKRYRKEIMDLKKQLEE--VSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIE 395
Query: 404 NLTRELENGEKQQLQMLDRLKEIQNHFDTCEAE------RKHADLQISELTRHAEDATKQ 457
NLTR L LQ + K + C + +AD Q + T K
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKR-KRRVTWCLGKINKMKNSNYAD-QFNIPTNITTKTHKL 453
Query: 458 AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGK 517
+ L E+ +S + + D + + + L + +E L D L
Sbjct: 454 SINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLD 513
Query: 518 NNQILKEKDELKTQLYAA--LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSH-- 573
Q+ EK+E++ +L L + E L ++ TK+ QE +L + L+++ H
Sbjct: 514 YEQLRTEKEEMELKLKEKNDLDEFEALERK-----TKKD-QEMQLIHEISNLKNLVKHAE 567
Query: 574 --QADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLL 631
DLE E+ + ++ + E ++KK + K+E K L
Sbjct: 568 VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENI----------------KMDLS 611
Query: 632 EMQESIKDLSAIRADL--ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLE 689
ESI+D ++ L A +A + + + A L+ + + K + +E AT Q++ +
Sbjct: 612 YSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN---LELKEKMKELATTYKQMEND 668
Query: 690 RDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKI 749
++Q +L+ K K + +++ KE A N I K SL + + K
Sbjct: 669 IQLYQSQLE--------AKKKMQVDLE-------KELQSAFNEI--TKLTSLIDGKVPKD 711
Query: 750 HRGQLEKLKSQCDRLTEELTQNENENKKLK------LKYQCLKDQLEEREKHISIEEEHL 803
LE L+ + L +EL + EN+ L+ + + L ++E K I + E L
Sbjct: 712 LLCNLE-LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEEL 770
Query: 804 RRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFS--KDSVEKLKVFSSGPDIHY 861
+ + +L +++ E+ + +L IGK D T S K + ++ + F + +H
Sbjct: 771 HIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT---LHM 827
Query: 862 D---PHRWLAESKTKLQW----LCEELKERENREKNLRHQLMLCRQQLRNLT---ENKES 911
D ++ + E ++ L +E ++ ++ L+ +L Q+L+ T + + +
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
Query: 912 ELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSL---QDRVIALETSTQVALDH 968
E++ L +Q+E ++ L + REK + E+ Q+ EE+ +L +D + L+ S Q+ D
Sbjct: 888 EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 969 LES 971
L+S
Sbjct: 948 LKS 950
Score = 74.3 bits (181), Expect = 6e-13
Identities = 157/892 (17%), Positives = 378/892 (42%), Gaps = 135/892 (15%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRS--- 92
E T+K++ + L++++ L++ Q L A EH +L++ +++ +
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELK-----------ANEHQLITLKKDVNETQKKVS 1847
Query: 93 --QRLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVR 150
++L + +S++++ L +L+ +LH ++ + + + M+ R +R
Sbjct: 1848 EMEQLKKQIKDQSLTLSKLEIENLN--LAQKLH--------ENLEEMKSV--MKERDNLR 1895
Query: 151 FVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA 210
V+ET + + +SL++ + + + +EL E K +++L EK++E
Sbjct: 1896 RVEETLKLER-DQLKESLQETKARDLEI----QQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 211 QKQ--------EVVSDRVERRLQELEREMRTERELVERRQD-QLGLMSLQLQEALKKQ-- 259
Q + D +++++QEL+++ E +L+ ++D + + E LKKQ
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKK---ELQLLRVKEDVNMSHKKINEMEQLKKQFE 2007
Query: 260 -------EAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL------ 306
+ D + + KL ++ E + +E + RR+ + R+ +
Sbjct: 2008 AQNLSMQSVRMDNFQ--LTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 307 -------HQVEELRTQLTKAEGD-RKGLQHQVSQISKQQSNYQD-EQGEDWRFRRGVERE 357
HQV+ + L+ + + L+ + S+I + Y + + + R ++ E
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125
Query: 358 KQ-DLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
K+ + +K++S +RV+ N S + + +++ + ++ L L K +
Sbjct: 2126 KEIEFQKELS-MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK 2184
Query: 417 LQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAE----RYLSELQQSEALK 472
+ + + + + F ++K ++I L + + +++ +L E LK
Sbjct: 2185 EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 473 EEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL---- 528
+ +E +K + Q+ + K++ + LE+ T ++ N I KE D +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSN----RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300
Query: 529 ---KTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
++ A + + + + + + L K EKL K++Q +K SL
Sbjct: 2301 NFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL--FKNYQT-----LKTSL 2353
Query: 586 DTIHRLE--SELKKQSKIQS---QMKVEKAH-LEEEIAELKKSQAQDKAKLLEMQESIKD 639
+ ++ ++ K + S Q+ EK LE + E K+S ++K+++MQ+ ++
Sbjct: 2354 ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEV 2413
Query: 640 LSAIRADL------ANKLAEEERAKKAVLKDLSDLTAQA-KSRDEETATIITQLKLERDV 692
+ I A L +NK E+ + VL+D L A+ K E+ + ++ LE+
Sbjct: 2414 TNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMK 2473
Query: 693 HQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHI------------------- 733
+ +E + S+ ++ ++ I+ L ++ ++ + + +
Sbjct: 2474 NAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGG 2533
Query: 734 ----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQL 789
+ KA L+ +++ ++ KLK Q ++L ++ + + N+ L + + K++
Sbjct: 2534 SGIVQNTKALILKSEHIRL--EKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERT 2591
Query: 790 EEREKHISIEEEHLRRMEE--ARLQLKDQLLCLETEQESILGVIGKEIDAAC 839
+RE H + E+ + + K Q+ + ++ ++ + KE +C
Sbjct: 2592 LKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSC 2643
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 152 bits (383), Expect = 2e-36
Identities = 182/897 (20%), Positives = 373/897 (41%), Gaps = 102/897 (11%)
Query: 150 RFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE 209
R VQE + Q+ Q+L+D Q L F ++ S R+ + E E
Sbjct: 216 RVVQEENQHMQMT--IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
Query: 210 AQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA 269
++Q + + L+E+E + T+++ + R + + + LQ K AKA E +
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS--KGLSAKATEEDHE 331
Query: 270 IKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQ 329
+L + E + LE LE + ++ RE + H+ E K + + ++ +
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEK---ENSMLREEM-HRRFENAPDSAKTKALQTVIEMK 387
Query: 330 VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA-MASELEEVKRCM 388
S+IS + +D + E + ++ E++M + V + S M +++ +VK+ +
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQEL 447
Query: 389 ERKDKEKAHLASQVENLTRELENGEKQQLQML--------DRLKEIQNHFDTCEAERKHA 440
RKD E L +++E LT + + KQ +++L R +Q D +
Sbjct: 448 SRKDTELLALQTKLETLTNQFSDS-KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 506
Query: 441 DLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKL 500
+ +++ T+ +D ++ E+ + + + E++ L+ K + Q + K K++
Sbjct: 507 ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 566
Query: 501 ----ERALEKQSETV----------DELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
ER Q++T + L K I + K++ ++I+N +K+L
Sbjct: 567 SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDL 626
Query: 547 NDVLTKRALQEEELHSKEEKLRDIKSHQADL--------------ELEVKNSLDTIHRLE 592
D+ K +L + +L KE L D+K H + L E+ ++ + ++E
Sbjct: 627 KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 686
Query: 593 SELKK------QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRAD 646
S+LKK +++ +M HLE EI K ++ +A++ + E +K++ + D
Sbjct: 687 SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 746
Query: 647 LANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQS 706
K+AE ER K K +++L + + +++A ++ + + D L D + LQ
Sbjct: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRED----NLNDSSQQLQD 802
Query: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTE 766
K + I+EL + ++ L E N K Q+E+L +++ +
Sbjct: 803 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEK----QVEELLMAMEKVKQ 858
Query: 767 ELTQNENENKKLKLKYQCLKDQLEEREKHI-SIEEEHLRRMEEARLQLKDQLLCLETEQE 825
EL + +K K + L E+E H+ ++ E + +EE ++ LL +E++
Sbjct: 859 EL-------ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 911
Query: 826 SILGV----------------IGKEIDAACKTFSKDSVEKLKVFSSG-PDIHY-DPHRWL 867
+ + + + +E D + + + ++K+ + D H+ H
Sbjct: 912 ANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 971
Query: 868 AESKTKLQWLCEELKERENREKNLR----HQLMLCRQQ----LRNLTENKESELQCLFQQ 919
K + + L E + L+ H LC + LR LT L Q
Sbjct: 972 TNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD--DDQ 1029
Query: 920 IERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKL 976
+ +L + +D LE+ +R + E+ + ++ Q DH + E++
Sbjct: 1030 AAWENELQKMTRGQLQDELEKGERDNAELQEFANAIL------QQIADHCPDILEQV 1080
Score = 90.5 bits (223), Expect = 8e-18
Identities = 125/570 (21%), Positives = 260/570 (45%), Gaps = 79/570 (13%)
Query: 449 RHAEDAT-KQAERYLSE-LQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
R A D T + L E L++++ L+++ E + L + SI+ + K ERAL K
Sbjct: 144 RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS-SSMNSIKTFWSPELKKERALRK 202
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK 566
+ + + ++++E+++ ALQ ++++LN +L ++
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-----------QLFQQDSS 251
Query: 567 LRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKS-QAQ 625
R + A+L E RL +E ++Q+K ++ +E I K++ A+
Sbjct: 252 SRTGEPCVAELTEE------NFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
Query: 626 DKA--KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATII 683
D++ KLLEM +S K LSA K EE+ + L A+A+ +++
Sbjct: 306 DESIKKLLEMLQS-KGLSA-------KATEEDHERTRRL-------AEAEMHVHHLESLL 350
Query: 684 TQLKLERDVHQREL-KDLTSSLQSVKTKHEQNIQEL----MKHFKKEKSEAENHIRTLKA 738
Q + E + + E+ + ++ S KTK Q + E+ + ++ + E I+ LK+
Sbjct: 351 EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
Query: 739 -------ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEE 791
E EE +++R + +K++ ++ +EL++ + E L+ K + L +Q +
Sbjct: 411 NGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470
Query: 792 REKHISIEEEHLRRMEEARLQLKDQLLCLE---TEQESILGVIGKEID--AACKTFSKDS 846
++HI + +E L E+ L+ ++ L E+E++L K+I A K
Sbjct: 471 SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 530
Query: 847 VEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLT 906
+ LK D+ R + + K++ L E+L+++E + +L+ ++ + L+ T
Sbjct: 531 IHDLK------DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV----KSLQADT 580
Query: 907 ENKESELQCLFQQIERQEQLLDEI----HREKRDLLEETQRKDEEMGSLQDRVIALETST 962
N ++ L L + + +E+ ++ + R++R+ EE +++ L+++V L+
Sbjct: 581 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ--- 637
Query: 963 QVALDHLESVPEKLSLLEDFKDFRDSCSSS 992
+ EK + L D K+ S +SS
Sbjct: 638 -------GDLSEKEASLLDLKEHASSLASS 660
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 150 bits (380), Expect = 5e-36
Identities = 198/982 (20%), Positives = 427/982 (43%), Gaps = 137/982 (13%)
Query: 132 KDYGDPQG-IKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRS 190
+ G+ G +K R + + + + + L L + E++ + +L +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 191 RSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSL 250
+ E + + T KL EAQ ++V R++ + +++++ L+++ ++ + L+
Sbjct: 488 QQHQEQQALQQSTTAKLREAQND---LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 251 QLQEALKKQEAKADEHEGAIKNKLRQTETEKNQL--EQELELSRRLLNQSEG---SRETL 305
+ ++ K +A E E A+ N+L+ EKN EQ +L+ +L NQSE ++E L
Sbjct: 545 EREDLYAK--IQAGEGETAVLNQLQ----EKNHTLQEQVTQLTEKLKNQSESHKQAQENL 598
Query: 306 LHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGE-DWRFRRGVE---REKQDL 361
QV+E + L A+ L+ V++++ Q + +++ + D + + E +
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 362 EKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLD 421
Q +DL+ + L+ + ++ K +E + +Q++ +T +L++ ++ Q+
Sbjct: 659 TAQRADLQ---------NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 422 RLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRED 481
LKE + + + E + + + QI +L + + E+ L +LQQ L + E R +
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 482 LKLKAQ---ESIRQWKLKHKKLERALE--KQSETVDELTGKNNQILKEK----------- 525
L + + E + +L +K ALE KQ T E + QILK+
Sbjct: 770 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE---EEKQILKQDFETLSQETKIQ 826
Query: 526 -DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNS 584
+EL ++ + +++ ++ E ++T+ + +++L + L++ KS + K +
Sbjct: 827 HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
Query: 585 LDTIHRLESELKKQSKIQSQMKV-EKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAI 643
+ + + ELK Q ++Q + + E+ L++ + + K++ Q K +L MQE + I
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL-----I 941
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLK--------LERDVHQR 695
+A N L + E+ ++ + ++++L ++ + ++ + +LK LE + Q+
Sbjct: 942 QAQ--NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 696 ------EL---KDLTSSLQSVKTKHEQNIQELMKHFKKEKSE----------AENHIRTL 736
EL K+ S LQ+ K ++ ++L F +SE E +
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 737 KAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHI 796
+ + + +N +++LK+ L ++ + E + ++ Q ++ + +EK +
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 797 SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSG 856
E+ L +EE + + + ++ L E +S K S + LK
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKS------------HKLESIKEITNLK----- 1162
Query: 857 PDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCL 916
D + L + K +LQ + LK +EK R+Q Q L++ + +E EL+
Sbjct: 1163 -----DAKQLLIQQKLELQGKADSLKAAVEQEK--RNQ-----QILKDQVKKEEEELKKE 1210
Query: 917 FQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKL 976
F IE++ +L EI ++ + ++ +E L ++ AL + +S ++
Sbjct: 1211 F--IEKEAKLHSEIKEKEVGM----KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
Query: 977 SLLE-DFKDFRDSCSSSERT------------------DGRYSKYRVRRNSLQHHQDDTK 1017
S LE D R + E T +G K + + LQ D+T
Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTT 1324
Query: 1018 YRTKSFKGDRTFLEGSHTRGLD 1039
+ + L+ HT+ L+
Sbjct: 1325 AAVQELGRENQSLQIKHTQALN 1346
Score = 147 bits (372), Expect = 4e-35
Identities = 204/994 (20%), Positives = 426/994 (42%), Gaps = 111/994 (11%)
Query: 37 VTEKVNTITSTLQDTSRNLRQ---VDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQ 93
+TE++N + +QD L Q ++ + +E Q ++++ E+ ++L+ +
Sbjct: 196 LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT-LMDNMTLERERESEKLKDE 254
Query: 94 -RLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFV 152
+ L++ S + S S+L G + LK + + +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS--SVNELTQKNQTLTENLL 312
Query: 153 QETDDMTQLHGFHQ----SLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLN 208
++ D T+L H S +++ + + D + SR S S+ R EL+EK
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268
QK + VE + Q L+ E + ++ E ++ LQLQ + + +K E E
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH----GLQLQSEINQLHSKLLETE- 427
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH 328
RQ +L+++ +LS L E L ++ L QL + + LQH
Sbjct: 428 ------RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481
Query: 329 QVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCM 388
Q+ + +Q Q Q R + + + + +Q+ D +++ ++ +
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD---------KDQKIQNLEALL 532
Query: 389 ERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
++ + + L + E+L +++ GE + +L++L+E +NH + Q++E
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETA-VLNQLQE-KNH------TLQEQVTQLTEKL 584
Query: 449 RHAEDATKQAERYL-SELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQ 507
++ ++ KQA+ L ++Q+ +A A+ R L+ E + +L + EK
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL-------NSQLNESKEKV 637
Query: 508 SETVDELTGKNNQILK-------EKDELKTQLYAALQQIENLRKELNDVLTKRALQEEEL 560
S+ ++ K +L ++ +L+ L A +++ ++ELN + T+ +L
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 561 HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELK 620
K+E ++SH + + + + LE ++KK ++K K +++ + +
Sbjct: 698 QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR 757
Query: 621 ------KSQAQDKAKLLEMQESIKDLSAIRADL----------ANKLAEEERAKKAVLKD 664
+ +A + +K LEM++ I +S+ R DL KL ++E K+ + +D
Sbjct: 758 QLNTDLELRATELSKQLEMEKEI--VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 665 LSDLTAQAKSRDEE-------TATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQE 717
L+ + K + EE T T + ++K+E++ EL + L V +++
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV----SDSLKN 871
Query: 718 LMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKK 777
F+KE + + I L+ E K+ ++ Q+E + L + L + + + +
Sbjct: 872 SKSEFEKENQKGKAAILDLEKTCKELKHQLQV---QMENTLKEQKELKKSLEKEKEASHQ 928
Query: 778 LKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDA 837
LKL+ +++QL + + + E+ EE +LQ L +EQ+ K+I+A
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEK-----EEQQLQGNINELKQSSEQKK------KQIEA 977
Query: 838 ACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLR----- 892
++K ++ + + LA K K+ L ++ + K L+
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1037
Query: 893 --HQLMLCRQQLRNLTEN---KESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEE 947
+L+ RQ L+++ E + +L QI Q +L+ E+ K L +++ +K+++
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
Query: 948 MGSLQDRVIAL-ETSTQVALDHLESVPEKLSLLE 980
LQ+R AL + + +L E V EK L E
Sbjct: 1098 ---LQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128
Score = 140 bits (354), Expect = 5e-33
Identities = 190/916 (20%), Positives = 382/916 (41%), Gaps = 95/916 (10%)
Query: 164 FHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR 223
F Q L++E + ++ E S R ++ + R EEL ++ Q++ ++ ++R
Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI--QDLKTELLQRP 218
Query: 224 LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQ 283
E ++ E V+ D + L + E LK + K + + + Q +E +
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278
Query: 284 LEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE 343
QE+ + + L + + S L + + L L K E D L+ + ++ S + N Q
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT 338
Query: 344 QGEDWRFRRGVEREKQDLEKQMSDL-----RVQLNFSAMASELEEVKRCMERKDKEKAHL 398
+ + + Q L+ ++S R+ + S +++K + + + HL
Sbjct: 339 LHQK-------DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
Query: 399 ASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQA 458
++ + L ++ E E+ LQ+ + ++ + E + A ++ E + + +
Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 459 ERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKN 518
E+ +++LQ + EE K + + Q + + K +H++ + + + + E
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 519 NQILK---EKDELKTQLYAALQQ----IENLRKELNDVLTKRALQEEE---LHSKEEKLR 568
Q+L+ +KD+ L A LQ+ I L KE D+ K E E L+ +EK
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH 571
Query: 569 DIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHL---EEEIAELKKSQAQ 625
++ L ++KN + ES + Q + Q++ +KAHL ++ + L+ S +
Sbjct: 572 TLQEQVTQLTEKLKN------QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 626 DKAKLLEMQESIKDL------------------SAIRADL-------ANKLAEEERAKKA 660
++L E +E + L +A RADL N L ++++
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 685
Query: 661 VLKDLSDLTAQAKSRDEETATIITQLK--------LERDVHQRE--LKDLTSSLQSVKTK 710
+ L +TA+ + + E + + + LK LE+ + E +K L + VK
Sbjct: 686 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
Query: 711 HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770
EQ +Q+L + ++ ++ E L + EK + R L+K + + ++LT+
Sbjct: 746 KEQALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 771 NENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGV 830
E E + LK ++ L E + +H + + E + ++K + L TE ++
Sbjct: 805 QEEEKQILKQDFETLSQ--ETKIQHEELNNRIQTTVTELQ-KVKMEKEALMTELSTVKDK 861
Query: 831 IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCE-------ELKE 883
+ K D+ + S+ E K G D + E K +LQ E ELK+
Sbjct: 862 LSKVSDSLKNSKSEFEKENQK----GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 884 RENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR 943
+EK HQL L +L ++ E L Q + ++QL I+ K+ ++ ++
Sbjct: 918 SLEKEKEASHQLKL---ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 944 KDEEMGSLQDRVI-------ALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTD 996
+ G L+ V+ L+ A L + EK+S+L++ + ++D
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 997 --GRYSKYRVRRNSLQ 1010
GR S+ R L+
Sbjct: 1035 FYGRESELLATRQDLK 1050
Score = 111 bits (278), Expect = 3e-24
Identities = 166/804 (20%), Positives = 352/804 (43%), Gaps = 105/804 (13%)
Query: 252 LQEALKKQEAKADEHEGAIKNKLRQTETEKNQ-LEQELELSRRLLNQSEGSRETLLHQVE 310
LQ +LK+++ ++E + E EK Q L+Q+ L+ S ++L Q+E
Sbjct: 95 LQASLKEEKWYSEE---------LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLE 145
Query: 311 ELRTQLTKAEGDRKGLQHQVSQISKQ----QSNYQDEQGEDWRFRRGVEREKQDLEKQ-- 364
E +T+ + + + + +Q++ + +S Y +E+ + V R ++L K+
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 365 -MSDLRVQL-------NFSAMASELEEVKRCME----RKDKEKAHLASQVENLTRELENG 412
+ DL+ +L + + + EL +V+ M+ +++E L + + L + +
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 413 EKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRH----AEDATKQAERY--LSELQ 466
E Q+ L + E + ++ELT+ E+ K+ + Y L E
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 467 QSEALKE---EAEKRREDL-------KLKAQE-SIRQWKLKHKKLERALEKQSETVDELT 515
E++ + +A ++DL +L A E S+ + ++ + A +K E + E+
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 516 GKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEEL---HSKEEKLRDIKS 572
K + E +L+ Q Q L+ E+N + +K E +L H + ++ R + S
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 573 HQ-ADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLL 631
+ D E +V + + RLE +LK++ ++++ + +++ E + Q AKL
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 632 EMQESIKDLSAIRADLANKLAEEE----RAKKAVL---KDLSDLTAQAKSRDEETATIIT 684
E Q ++ + D K+ E ++K+ + K+ DL A+ ++ + ETA ++
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA-VLN 564
Query: 685 QLKLERDVHQRELKDLTSSLQSVKTKHEQ---NIQELMKHFKKEKSEAENHIRTLKAESL 741
QL+ + Q ++ LT L++ H+Q N+ + ++ K A++ + +L+
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 742 EEKNMAKIHRGQLEKLKSQCDRLTE--------------------ELTQNENENKKLKLK 781
E + + ++ +L Q TE + QN ++K+ +L
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 782 YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 841
+ QL++ + ++EH ++E + K++ L LE + E + G I K+++A
Sbjct: 685 K--ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI-KKLEA---- 737
Query: 842 FSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQ 901
+ L+V +S D + + T L+ EL ++ EK + L Q+
Sbjct: 738 ------DSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 902 LRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGS-LQDRVIALE- 959
K L+ + Q++ +QE+ + ++ L +ET+ + EE+ + +Q V L+
Sbjct: 791 -------KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 960 --TSTQVALDHLESVPEKLSLLED 981
+ + L +V +KLS + D
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSD 867
Score = 82.8 bits (203), Expect = 2e-15
Identities = 128/673 (19%), Positives = 277/673 (41%), Gaps = 91/673 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYS----------NGQAGAIE----HLKE 81
++T +++ +T+ LQD + Q++ L Y+E GQ +E +K
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 82 SLEQSIDQLRSQRLLRN---------SGGRSISVTSLSASDLDGGTGSELHHFPPTSPLK 132
S EQ++ L+ QR L S + +S++ LD SE K
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 133 DYGDPQGIKR-----------------MRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQ 175
+ Q +K+ R +T V +Q+ + L + +
Sbjct: 805 QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK--MEKEALMTELSTVKDKL 862
Query: 176 IRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQ-EVVSDRVERRLQELEREMRTE 234
++ D S + + + K A+ +L + E + Q +V + + +EL++ + E
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 235 RELVERRQDQLGLMSLQL---QEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQ-ELEL 290
+E + + +L M QL Q LK+ E + + +G I + +E +K Q+E + EL
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Query: 291 SRRLLNQSEGS---RETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGED 347
+L ++E ++ L +EL + K + + + QS++ + E
Sbjct: 983 KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Query: 348 WRFRRGVEREKQDLEKQMSDL---RVQL-NFSAMASELEEVKRCME----RKDKEKAHLA 399
R+ ++ ++ L DL R Q+ N + + EL+ K +E +K+++
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 400 SQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQ-- 457
++++ +E EK+ + +L EI+ C E++ L EL H ++ K+
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEI--KCRQEKEITKLN-EELKSHKLESIKEIT 1159
Query: 458 ----AERYL-------------------SELQQSEALKEEAEKRREDLKLKAQESIRQWK 494
A++ L E + + LK++ +K E+LK + E +
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 495 LKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRA 554
+ K+ E ++K E +LT + + + +K + ++ +++ L K+ +D+ + A
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
Query: 555 LQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEE 614
+ E + + +++ R + E E++ + L+ +L + V++ E
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD-----NTTAAVQELGREN 1334
Query: 615 EIAELKKSQAQDK 627
+ ++K +QA ++
Sbjct: 1335 QSLQIKHTQALNR 1347
Score = 73.9 bits (180), Expect = 8e-13
Identities = 105/441 (23%), Positives = 195/441 (44%), Gaps = 73/441 (16%)
Query: 541 NLRKELNDV-LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS 599
NL + +DV L ++ +Q+ + KEEK E+K L+ L+ + K
Sbjct: 77 NLALKRDDVTLLRQEVQDLQASLKEEKW---------YSEELKKELEKYQGLQQQEAKPD 127
Query: 600 KIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKK 659
+ + E LE+++ E + K ++ L+ AD+ +K EE ++
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
Query: 660 AVLKDLSDLTAQAKSRDEETATIITQLKLER---------DVHQRELKDLTSSLQSVKTK 710
A + ++ LT + + AT+I LK E V ++EL + + + ++ +
Sbjct: 188 AAEQKVTRLTEEL----NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 711 HEQNIQELMKHFKKEKSE---AENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
E+ ++L KK +S+ +E I L++E + ++ +L+KLKS + LT++
Sbjct: 244 RERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQK 303
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKD----QLLCLETE 823
Q EN LK + +LEE+ S+ ++++ +A L KD QL +
Sbjct: 304 -NQTLTEN---LLKKEQDYTKLEEKHNEESVSKKNI----QATLHQKDLDCQQLQSRLSA 355
Query: 824 QESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE 883
E+ L I E+ ++ +KLK L+E +TK Q L E K+
Sbjct: 356 SETSLHRIHVELSE-----KGEATQKLK-------------EELSEVETKYQHLKAEFKQ 397
Query: 884 -RENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIH---REKRDL-L 938
++ RE+ +H L L +SE+ L ++ E+ L E H +E+R L
Sbjct: 398 LQQQREEKEQHGLQL------------QSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 939 EETQRKDEEMGSLQDRVIALE 959
E+ K++++ LQ ++ LE
Sbjct: 446 EKLMDKEQQVADLQLKLSRLE 466
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 150 bits (378), Expect = 8e-36
Identities = 194/876 (22%), Positives = 391/876 (44%), Gaps = 126/876 (14%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
Q R+L E+ +L +EL RR R + E ++ ++L Q++E + ERR Q
Sbjct: 266 QRQRELQEEEEQLRKLERQEL-RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLE 285
+ RE + ER + R++Q E ++Q+ + ++ E + +LR+ E E+ + E
Sbjct: 325 QERREQQEERREQQLRREQ---------EERREQQLRREQEEERREQQLRR-EQEEERRE 374
Query: 286 QELELSRRLLNQSEGSRETLLHQVEELR--------------------TQLTKAEGDRKG 325
Q+L ++L + + RE L + ++LR QL + + + +
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 326 LQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVK 385
Q + +Q+ + E+ DW +R E E+ + E++ L+ E E +
Sbjct: 435 EQKHEQERREQRLKREQEERRDW-LKREEETERHEQERRKQQLK-------RDQEEERRE 486
Query: 386 RCMERKDKEKAHLASQVE-NLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI 444
R ++ +++E+ + E L RE E +Q+L+ + + +Q R L+
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL------RSEQQLRR 540
Query: 445 SELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLK---HKKLE 501
+ R + ++ E+ L + ++ + LK E E+RR+ L LK +E RQ +LK ++LE
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL-LKREEERRQQRLKREQEERLE 599
Query: 502 RALEKQSETVDELTGKNNQILKE---KDELKTQLYAALQQIE----NLRKELNDVLTKRA 554
+ L+++ E + Q LK ++E + QL + +Q E LR+E + +R
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659
Query: 555 LQEEELHSKEEKL-RDIKSHQADLELEVKNSLDTIHRLESELKK------------QSKI 601
+EEE E++L R+ + + + EL + R++S + K QSK+
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 602 QSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDL--SAIRADLANKLAEEERAKK 659
S+ + ++ + E K+ + + + + E + + + R D + EE++++
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 660 A--------VLKDLSDLTAQAKSRDEETATII------TQLKLERDVHQRELKDLTSSLQ 705
L++ + +A+ R + + Q + +R ++EL+ L Q
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 706 SVKTKHEQNIQE----LMKHFKKEKSEAENHIRTLKAESLEEKNMAKIH--------RGQ 753
+ + Q +QE L + ++ +S+ + + + + LEE+ + H + Q
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ-LEEERKRRRHTLYAKPALQEQ 898
Query: 754 LEKLKSQCDRLTEELTQNENENKKLKLKYQCLK--DQLEEREKHISIEE-EHLRRMEEAR 810
L K + EEL + E E ++ + + + + +QL++ E+ + EE E RR E R
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 811 LQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAES 870
KD+ L + EQ ++G+E + + E+ K + ++ + + L E
Sbjct: 959 QYRKDKKLQQKEEQ-----LLGEEPE------KRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 871 KTK---LQWLCEELKE---RENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQE 924
+ K +W + K+ ++ E+ LR + R Q R +E ELQ + +E
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ------QEEE 1061
Query: 925 QLL-DEIHREKRDLLEETQRKDEEMGSLQDRVIALE 959
QLL +E +R LE RK+EE+ +++++ E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Score = 140 bits (354), Expect = 5e-33
Identities = 177/781 (22%), Positives = 353/781 (45%), Gaps = 90/781 (11%)
Query: 195 ETKRALEELTEKLNEAQKQEVVSDRVERRLQELERE---MRTERELVERRQDQLGLMSLQ 251
E KRA + E L + ++QE R E R ++LE E R ++ + R+ G +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 252 LQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEE 311
QE L++++ + + E + + Q E+ E++L QS ET EE
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL--------QSCKGHETEEFPDEE 208
Query: 312 LRTQLTKAEGDRKGLQHQVSQISKQQSN-YQDEQGEDWRFRRGV-EREKQDLEKQMSDLR 369
+ E RKG + + Q ++Q +Q+E+ ++WR R V +E++ L+++ +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 370 VQLNFSAMASELEEVKRCMERKD--KEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQ 427
+L E EE R +ER++ +E+ Q + L RE + KQ+ + ++ +E +
Sbjct: 269 REL------QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 428 NHFDTCEAERKHADLQI---------SELTRHAEDATK--QAERYLSELQQSEALKEEAE 476
+ E + + + Q+ +L R E+ + Q R E ++ + L+ E +
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 477 KRREDLKLKAQESIRQWKLKHK---KLERALEKQSETVDELTGKNNQILKEKDELKTQLY 533
RRE + Q+ R+ +L+ + + E+ L ++ + E + Q +E+ E K +
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-EEERHEQKHEQE 441
Query: 534 AALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQAD------LELEVKNSLDT 587
Q+++ ++E D L + +E E H +E + + +K Q + L+LE + +
Sbjct: 442 RREQRLKREQEERRDWLKRE--EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 588 IHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADL 647
R E +L+++ + + + ++++ EE + + +S+ Q + + E +E +
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE------ 553
Query: 648 ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV 707
K E+ER ++ + ++ + Q R+EE Q +L+R+ +R L L+
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEER----RQQRLKREQEER----LEQRLKRE 605
Query: 708 KTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
+ + + + + K+E+ E E + LK+E EE+ ++ R Q E+ + + R EE
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
E ++LK +++ EER + EEE E+AR ++K ++ + + ES
Sbjct: 666 ----ERLEQRLKREHE------EERREQELAEEE----QEQARERIKSRIPKWQWQLES- 710
Query: 828 LGVIGKEIDA-ACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKEREN 886
E DA K +S+ ++ G + +++LQW EE R+
Sbjct: 711 ------EADARQSKVYSRPRKQE------GQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 887 REKNLRHQLMLCRQQLRNLTENKESELQC---LFQQIERQEQLLDEIHREKRDLLEETQR 943
+E+ R + Q +E L L +Q ERQ + + RE+R L EE ++
Sbjct: 759 QEEEQRRD-FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 944 K 944
+
Sbjct: 818 E 818
Score = 140 bits (353), Expect = 7e-33
Identities = 191/907 (21%), Positives = 390/907 (42%), Gaps = 137/907 (15%)
Query: 136 DPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRR------ 189
+ Q +R+R +R QE + Q + ++ R RE R
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 190 -----SRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQ 244
R + + +R EE + ++Q++ ++ RR Q+L RE + RE RR+ Q
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 245 LGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRET 304
L+ ++ L++++ E E + + E + +L++E E R L + E ET
Sbjct: 413 -----LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE---ET 464
Query: 305 LLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQ 364
H+ E + QL + + + + + + ++ +++ Q E+ E R ER +Q L++Q
Sbjct: 465 ERHEQERRKQQLKRDQEEER--RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 365 MSDLRVQLNFSA---MASELEEVK-RCMERKDKEKAHLASQVENLTRELENGEKQQLQML 420
+ R+Q + + E EE + + ++R+++++ + + L RE E Q L+
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 421 D-----RLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEA 475
+ RLK Q + E K +++ E E K+ E QQ +E+
Sbjct: 583 EERRQQRLKREQE--ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 476 EKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDE-----LKT 530
E+R++ L+ + QE R+ +LK ++ E LE++ + E + ++ +E+ E +K+
Sbjct: 641 ERRQQQLRREQQER-REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 531 QLYAALQQIEN----------LRKELNDVLTKRALQEEELHSKEEKLR---DIKSHQADL 577
++ Q+E+ R + +R QEE+ +E +L+ + ++H+
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 578 ELEVKNS-----------------LDTIHRLESELKKQSKIQSQMKVEKAHL-EEEIAEL 619
E E + L L + ++Q + + + + E+ L EEE E
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819
Query: 620 KKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEE- 678
++ Q +++ K L+ E + L R + A +L EEE + +D +Q + RD++
Sbjct: 820 RRRQRREREKELQFLEEEEQLQ--RRERAQQLQEEE---DGLQEDQERRRSQEQRRDQKW 874
Query: 679 -----------------TATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQ----- 716
+ QL+ E+ + Q E ++L + + + EQ Q
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 717 -------ELMKHFKKEKSEAENHIRTLKAESLEEK-------NMAKIHRGQLEKLKSQCD 762
+L++ ++++ E + K + L++K K R + EK + +
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 763 RLTEELTQ--NENENKKLKLKYQ---CLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL 817
L +E Q E K+ + +++ KD+L++ E+ + EE RR++E Q +++
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054
Query: 818 LCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL 877
L+ E+E +LG +T + +E+ Y L + + +L
Sbjct: 1055 E-LQQEEEQLLG-------EERETRRRQELER----------QYRKEEELQQEEEQLLRE 1096
Query: 878 CEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDL 937
E + R+ RE+ R + L +++ + L E +E + Q++ERQ + +E+ +E+ L
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELERQYREEEEVQQEEEQL 1153
Query: 938 LEETQRK 944
L E K
Sbjct: 1154 LREEPEK 1160
Score = 131 bits (329), Expect = 4e-30
Identities = 181/858 (21%), Positives = 373/858 (43%), Gaps = 79/858 (9%)
Query: 197 KRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEAL 256
+R L EL K E +KQ+ +R +R QE E + +RE V R++++ LQ +E
Sbjct: 212 RRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE----KLQEEEPQ 266
Query: 257 KKQEAKADEHE--GAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
+++E + +E + + +LR+ E+ Q +Q L ++L + E R Q EE R
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR---EQQEERRE 323
Query: 315 QLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNF 374
Q + E + + Q+ + +++ Q + ++ R R +Q+ E++ LR +
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE--- 380
Query: 375 SAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQL---QMLDRLKEIQNHFD 431
+L ++ + + + + L RE + +QQL Q L R +E + H
Sbjct: 381 ----QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 432 TCEAERKHADLQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRRED-LKLKAQES 489
E ER+ L+ E R ++ ER+ E ++ + +++ E+RRE LKL+ +E
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 490 IRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV 549
Q + + ++L R E++ E Q LK ++E + +L L+ + LR+E +
Sbjct: 497 REQQERREQQLRREQEERRE----------QRLKRQEE-EERLQQRLRSEQQLRREQEER 545
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS-KIQSQMKVE 608
+ +EEE ++E+ + L+ E + D + + E E ++Q K + + ++E
Sbjct: 546 REQLLKREEEKRLEQER------REQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 609 KAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL 668
+ EE+ L++ + +++ E E + R L +EER ++ + ++ +
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEER-----RQQLLKSEEQEERRQQQLRREQQER 654
Query: 669 TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSE 728
Q R+EE + +LK E + +RE + + + + + I + + E
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 729 AENHI--RTLKAESLEEKNMAKIHRGQLE-KLKSQCDRLTEELTQNENENKKLKLKYQCL 785
++ + R K E + + R + E +L+ Q + Q E + + ++Q
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA- 773
Query: 786 KDQLEEREKHIS----IEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 841
+++ E + +S + E+ R++ Q ++Q E E++ +E + +
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 842 FSKDSV----EKLKVFSSGPD-IHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLM 896
++ E+ + D + D R ++ + + Q +L+E R ++ +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 897 LCRQQLR---NLTENKESELQ------CLFQQIERQEQLLDEIHREKRDLL----EETQR 943
++QLR L + +E ELQ Q+ ERQ + +++ +E+ LL E+ +R
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 944 KDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYR 1003
++ E +D+ + Q L PEK E K +R+ E R
Sbjct: 954 QERERQYRKDKKL-----QQKEEQLLGEEPEKRRRQEREKKYRE---EEELQQEEEQLLR 1005
Query: 1004 VRRNSLQHHQDDTKYRTK 1021
R + + + +YR K
Sbjct: 1006 EEREKRRRQEWERQYRKK 1023
Score = 128 bits (322), Expect = 3e-29
Identities = 207/951 (21%), Positives = 378/951 (39%), Gaps = 130/951 (13%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELER----------EMRTER- 235
SR + + + +R +E + E++ Q +R R+ QE E+ E ++ER
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 236 --------ELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQE 287
L E+R+ QL Q +E E + E + + R+ E E LE+E
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR---RRQRREREKELQFLEEE 837
Query: 288 LELSRRLLNQSEGSRETLLHQVEELRTQLT---------KAEGDRKGLQHQV-------S 331
+L RR Q E L + +E R + E +RK +H +
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 332 QISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERK 391
Q+ K+Q Q+E+ E R R R ++ + + ++Q + E E +R ER+
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 392 ---DKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
K+K + + L E E +Q+ + R +E E +++ L E
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE--------ELQQEEEQLLREERE 1009
Query: 449 RHAEDATKQAERYLSELQQSE--ALKEEAEKR---------REDLKLKAQESIRQWKLKH 497
+ ++ R ELQQ E L+EE EKR RE+ +L+ +E + +
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 498 KKLERALEKQSETVDELTGKNNQILKEKDELK------------TQLYAALQQI--ENLR 543
+ + LE+Q +EL + Q+L+E+ E + +L +Q+ E
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129
Query: 544 KELNDVLTKRALQEEELHSKEEKL---RDIKSHQADLELEVKNSLDTIHRLESELKKQSK 600
K L ++ +EEE+ +EE+L K + +LE + + + E L+++ +
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Query: 601 IQSQMKVEKAHLEEEIAELKKSQA---QDKAKLLEMQESIKDLSAIRADLA--------- 648
+ Q + + EEE+ K+ Q +D+ L+ Q + +A+R +
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249
Query: 649 -NKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV 707
+L + + + +DL L + + RD E Q +RD H E + L Q
Sbjct: 1250 FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ---QRDRHFPEEEQLEREEQKE 1306
Query: 708 KTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
+ ++ QE + ++E+ E T + EE+ + + Q + + + + EE
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQET-DRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRME-EARLQLKDQLLCLETEQES 826
+++ + +K + Q L+ Q ERE+ EE+ LR E E +L+ E EQ+
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 827 ILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKEREN 886
++ + + E+ K + + HR E + LQ E+ R+
Sbjct: 1424 SRQERDRKFREEEQQVRRQERER-KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 887 REKNLRHQLMLCRQQLRNLTENKESELQCLFQQIER----QEQLLDEIHREKRDLLEETQ 942
R++ + R+Q R + K E + Q+ ER +EQ L R+++ L EE Q
Sbjct: 1483 RDRKFLEEEQQLRRQER---DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 943 RKDEEMGS--LQDRVIALETSTQVALDHLES--------------------VPEKLSLLE 980
+ +E G QDR Q+ + E ++ +E
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599
Query: 981 DFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLE 1031
D + R + R K+R LQ ++ +R + DR FLE
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER---DRKFLE 1647
Score = 115 bits (288), Expect = 2e-25
Identities = 191/870 (21%), Positives = 375/870 (43%), Gaps = 108/870 (12%)
Query: 175 QIRLGDDFNRELSRRSRSDAETKRALE-----ELTEKLNEAQKQEVVSDRVERRLQELER 229
Q R ++ +E + + ET+R E E+L + ++Q + + +RR QE ER
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 230 EMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELE 289
+ R E EL + + L + + +++ + +E + +L + E EK + QELE
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR-RQELE 1167
Query: 290 LSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE-QGEDW 348
R + + E LL + +E R Q E +R+ + + Q K++ Y+DE Q D
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQ----ERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 349 RFRRGVERE------------------KQDLEKQMSDLRVQLNFSAMASELEEVKRCMER 390
+++ E+E +Q + Q+ D + Q + + E +E R ER
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 391 K----------DKEKAHLASQVENLTRELENGEKQQLQMLDR-----LKEIQNHFDTCEA 435
+ ++E+ Q E R+ ++ E++QL +R +E F E
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 436 ---ERKHADLQISELTRHAEDAT----KQAERYLSELQQSEALKEEAEKRREDLKLKAQE 488
ER+ L+ E R + +Q ++L E Q+ + E + +E+ +L+ QE
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 489 SIRQWKLKHKKLERALEKQ---SETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKE 545
+Q + + R E+Q E + + Q+ +++ E K L++ + LR+E
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF-----LEEEQQLRQE 1458
Query: 546 LNDVLTKRALQEEE--LHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQS 603
+ R +EEE L +EE+ + H+ + + + + R E + K + +
Sbjct: 1459 RH-----RKFREEEQLLQEREEQ----QLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 604 QMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRA-DLANKLAEEERAKKAVL 662
+ E+ LEEE +L + Q Q K E Q ++ R D K EEE+ ++
Sbjct: 1510 SQEPERKFLEEE-QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE-- 1566
Query: 663 KDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHF 722
++ L+ Q + R + + K+ R +R+ + L+ + + +Q QE + F
Sbjct: 1567 REEQQLSRQERDRKFR----LEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLRQERDRKF 1621
Query: 723 KK------EKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ--NENE 774
++ E+ E + H + + LEE+ + + ++L+ DR E Q E E
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQLLQEGE 1680
Query: 775 NKKLKL-----KYQCLKDQL--EEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++L+ K++ + QL +ERE+ EE+ LRR E R +++ L ETEQE +
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 828 LGVIGKEIDAACKTFSKDSV----EKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE 883
+ + K ++ + E+ ++ D + L + + + Q +E
Sbjct: 1741 -----RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 884 RENREKNLRHQL--MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLL--E 939
+ E+ LR + R Q R+ E E L +Q +R Q D +R + E
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 940 ETQRKDEEMGSLQDRVIALETSTQVALDHL 969
+++R+++E+ +++ E ++ +H+
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHI 1885
Score = 108 bits (270), Expect = 3e-23
Identities = 135/680 (19%), Positives = 299/680 (43%), Gaps = 69/680 (10%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE D + + Q R E+ +L + +E RR R E K+ L E E+
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEE-QLEREEQKEAKRRDRKSQEEKQLLREEREE------ 1327
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAI-- 270
+RR QE +R+ R E +L++ R++Q L + +++E + E
Sbjct: 1328 --------KRRRQETDRKFREEEQLLQEREEQ-PLRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 271 -KNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQ 329
+ +LR+ E E+ L++E +L R + + R+ + E QL++ E DRK + +
Sbjct: 1379 EEQRLRRQERERKFLKEEQQL--RCQEREQQLRQDRDRKFREEEQQLSRQERDRK-FREE 1435
Query: 330 VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCME 389
Q+ +Q+ R R+ +E E+Q +++ R + + E EE + +
Sbjct: 1436 EQQVRRQE-----------RERKFLEEEQQLRQERHRKFREE---EQLLQEREEQQLHRQ 1481
Query: 390 RKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTR 449
+D++ Q+ R+ + E++ K ++ +R+ LQ + R
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 450 HAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSE 509
E ++ + + ++ E L++E RE+ +L QE R+++L+ +K+ R +++
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQE----REEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 510 TVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRD 569
DE + + + +L+ + ++ E L +E + R ++ + +E +LR
Sbjct: 1598 MEDEQQLRRQE---GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR- 1653
Query: 570 IKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAH-LEEEIAELKKSQAQDKA 628
+ + E ++++ D R E +L ++ + Q + E+ EE +L++ + +
Sbjct: 1654 ----RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE--R 1707
Query: 629 KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKL 688
K L+ ++ ++ R +L K EEE+ ++ T Q + R +E I L+
Sbjct: 1708 KFLQEEQQLR-----RQELERKFREEEQLRQE--------TEQEQLRRQERYRKI--LEE 1752
Query: 689 ERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT---LKAESLEEKN 745
E+ +RE + L + K + E+ +++ + + E++ R L+ E E++
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Query: 746 MAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRR 805
+ G+ + Q +E + +++ + + Q + RE+ +EE +R
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Query: 806 MEEARLQLKDQLLCLETEQE 825
+E +L+++ + + ++E
Sbjct: 1873 RQERERKLREEHIRRQQKEE 1892
Score = 97.4 bits (241), Expect = 6e-20
Identities = 138/606 (22%), Positives = 276/606 (45%), Gaps = 66/606 (10%)
Query: 148 GVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRAL--EELTE 205
G +F++E + + + L++ +Q+R + + R R E ++ L +E
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKE--EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 206 KLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE 265
K E ++Q+V ER+ E E+++R ER R ++QL LQ +E + + D
Sbjct: 1431 KFRE-EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL----LQEREEQQLHRQERDR 1485
Query: 266 HEGAIKNKLRQTETEKNQLEQEL---ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD 322
+ +LR+ E ++ EQEL E R+ L + E LH+ +
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE-----EQQLHRQQR----------Q 1530
Query: 323 RKGLQHQVSQISKQQSNYQDEQGEDWRFRR----GVEREKQDLEKQMSDLRVQLNFSAMA 378
RK LQ + Q+ +Q+ Q Q D +FR ERE+Q L +Q D + +L +
Sbjct: 1531 RKFLQEE-QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 379 SELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERK 438
+ E+ ++ ME D+++ + L +E + ++ Q+L +E Q H E +RK
Sbjct: 1590 RQ-EQERKFME--DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ--ERDRK 1644
Query: 439 HAD-------LQISELTRHAEDAT-KQAERYLSELQQSEALKEEAEK--RREDLKLKAQE 488
+ + + RH D ++ E+ L E ++ + ++E ++ R E+ +L+ QE
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE 1704
Query: 489 SIRQWKLKHKKLER-ALEKQSETVDELTGKNNQILKEKDELKTQ-LYAALQQIENLRKEL 546
R++ + ++L R LE++ ++L + E+++L+ Q Y + + E LR E
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQET-----EQEQLRRQERYRKILEEEQLRPER 1759
Query: 547 NDVLTK-----RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI 601
+ + R +EEE +E + + ++S ++D + + L R E +L+ Q +
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ-EREEQQLRPQQR- 1817
Query: 602 QSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAV 661
+ + E+ L+ E E + Q +D+ E Q + ++ S R + EE++ ++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR-REEQELWQEEEQKRRQER 1876
Query: 662 LKDLSDLTAQAKSRDEETATIITQLK-LERDVHQRELKDLTSSLQSVKTKHE---QNIQE 717
+ L + + + ++E+ + ++K E H R L+ T SV + + IQE
Sbjct: 1877 ERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQE 1936
Query: 718 LMKHFK 723
++
Sbjct: 1937 QRSQYR 1942
Score = 85.5 bits (210), Expect = 3e-16
Identities = 107/495 (21%), Positives = 222/495 (44%), Gaps = 49/495 (9%)
Query: 471 LKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKT 530
L+EE +RR + + + + + + + +K ER ++ + DE + Q +E++E +
Sbjct: 129 LEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR- 187
Query: 531 QLYAALQQIENLR-KELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIH 589
A +Q+++ + E + + L+ EL K R+ K Q + D +
Sbjct: 188 ---AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR------RERQDRVF 238
Query: 590 RLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLAN 649
+ E E K+ K ++ ++ E+ L+EE + Q + +L E +E ++ L R +L
Sbjct: 239 Q-EEEEKEWRKRETVLRKEEEKLQEE-------EPQRQRELQEEEEQLRKLE--RQELRR 288
Query: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKT 709
+ EEE+ ++ + ++ Q + R E+ Q + +RE ++ Q +
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQ------QEERREQQERREQQEERREQQLRRE 342
Query: 710 KHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTE-EL 768
+ E+ Q+L + ++E+ E + L+ E EE+ ++ R Q + + Q R +
Sbjct: 343 QEERREQQLRREQEEERREQQ-----LRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Query: 769 TQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
Q ++L+ + Q ++Q RE+ + E+E R ++ + ++Q L+ EQE
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR--LKREQEERR 455
Query: 829 GVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
+ +E + + E+ K RWL + + + E +++ RE
Sbjct: 456 DWLKREEET-----ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 889 KNLRHQLMLCRQ-QLRNLTENKESELQCLFQQIERQEQL--------LDEIHREKRDLLE 939
+ R + L RQ + L + SE Q +Q ER+EQL L++ RE+R E
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 940 ETQRKDEEMGSLQDR 954
+ +R+D+ + ++R
Sbjct: 571 QEERRDQLLKREEER 585
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 150 bits (378), Expect = 8e-36
Identities = 191/867 (22%), Positives = 386/867 (44%), Gaps = 78/867 (8%)
Query: 184 RELSRRSRSDAETKRALEEL----TEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE 239
+EL ++ E K L+E TE EA++ V ++ L+E+ EM E E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR----QTETEKNQLEQELELSRRLL 295
R QL ++ + + E + +E E A + KL+ E + +LE E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 296 NQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVE 355
N+ R+ L ++ +L T L + E K L ++ S + ++ + R+ +E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 356 REKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ 415
+ K+ LE SD Q+ + + +++ E+K + +K++E +++++ + N K+
Sbjct: 1055 KLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 416 QLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEA 475
++ + ++Q D+ A R A+ Q +L E + E L + L+ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 476 EKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAA 535
E+ LK E R + + +++ +K ++ V+ELT + Q + K L
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 536 LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 595
++ +L EL + + E + E ++++++S +D E D +H+L++E+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEE 655
+ + + ++ + + L +++A L SQ QD +LL QE + + +++ KL + E
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASL-SSQLQDTQELL--QEETRQ----KLNVSTKLRQLE 1342
Query: 656 RAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---KTKHE 712
+ + L+D D +AK E I+ L ++ +++L+D S+++++ K + +
Sbjct: 1343 EERNS-LQDQLDEEMEAKQNLERH---ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 713 QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE 772
+ I+ L + + +EK+ A + + K +E + + +L S ++ + Q
Sbjct: 1399 KEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 773 NENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL----LCLETEQESIL 828
E K + KY +D+ E + + L R E L+ K++L L+ E E ++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 829 GV---IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE 885
+GK + K SK ++E + E KT+L+ L +EL+ E
Sbjct: 1518 SSKDDVGKNVHELEK--SKRALE----------------TQMEEMKTQLEELEDELQATE 1559
Query: 886 NREKNLRHQLMLCRQQL-RNL----TENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
+ + L + + Q R+L +N+E Q Q E + +L DE R++R L
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RKQRALAAA 1617
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLE-DFKDFRDSCSSSERTDGRY 999
++K E G L+D LE A+ E ++L L+ KDF+ E D R
Sbjct: 1618 AKKKLE--GDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQ-----RELEDARA 1666
Query: 1000 SKYRVRRNSLQHHQDDTKYRTKSFKGD 1026
S+ + + ++ + + KS + D
Sbjct: 1667 SRDEIFATAKENEK-----KAKSLEAD 1688
Score = 138 bits (348), Expect = 2e-32
Identities = 170/858 (19%), Positives = 374/858 (43%), Gaps = 104/858 (12%)
Query: 156 DDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEV 215
D++ Q + + +R+L L +D + E + R++++ + + EEL EA K E
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-----EALKTE- 1154
Query: 216 VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR 275
L++ T++EL +R+ ++ ++ L E + EA+ E +R
Sbjct: 1155 --------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--------MR 1198
Query: 276 QTETEK-NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS 334
Q + +L ++LE +R + +++TL + +L +L ++ ++H+ ++
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLN------------FSAMASELE 382
Q Q + + R R + + L+ ++ + LN ++++S+L+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
+ + ++ + ++K ++++++ L E + + Q + ++ + ++ H T + +
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 443 QISEL---TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKL---K 496
++ + E+ K+ ++ + L Q K A + E K + Q+ + +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 497 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQ 556
++L LEK+ D+L + I + + + + A E KE + RAL
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARAL- 1492
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEE 615
EE L +KEE R K +A++E ++ +S D + + EL+K + +++QM+ K LEE
Sbjct: 1493 EEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK- 673
EL QA + AK L ++ +++ L DL + + E ++ + + L + + +
Sbjct: 1552 EDEL---QATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 674 SRDEETATIITQLKLERDVHQRELK-DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENH 732
R + + KLE D+ EL+ D + K + +Q MK F++E +A
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 733 IRTLKAESLEEKNMAKIHRGQL----------EKLKSQCDRLTEELTQN----------- 771
+ A + E + AK L E+ + Q D EEL +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 772 ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLC------------ 819
++E ++L+ + L+++LEE + ++ + +R+ + QL ++L
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 820 --LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL 877
LE + + + + E++ A K+ K ++ L+ + + + ++ TK
Sbjct: 1788 QQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---- 1842
Query: 878 CEELKERENREKNLRHQL---MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
LK+++ + K + Q+ +Q + E + ++ L +Q+E E+ I+ +
Sbjct: 1843 --SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 935 RDL---LEETQRKDEEMG 949
R L L+E +E MG
Sbjct: 1901 RKLQRELDEATESNEAMG 1918
Score = 125 bits (315), Expect = 2e-28
Identities = 166/793 (20%), Positives = 334/793 (42%), Gaps = 151/793 (19%)
Query: 154 ETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKR-----ALEELTEKLN 208
E +D Q LR +++ + E +R + + R A+EELTE+L
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268
+ ++ + D+ ++ L++ ++ E ++ + + ++ +L+ +++ ++K + E
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEG------- 321
A + + ++L+ E+E +LN++EG L V L +QL +
Sbjct: 1274 A----RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 322 DRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQL-NFSAMASE 380
+ + ++ Q+ +++++ QD+ E+ ++ +ER L Q+SD + +L +F++
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 381 LEEVKRCMERK------------------DKEKAHLASQVENLTRELENGEKQQLQMLDR 422
LEE K+ +++ +K K L ++++L +L+N Q Q++
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQLVSN 1445
Query: 423 LKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS--EALKEEAEKRRE 480
L++ Q FD AE K+ + ++ AE ++ E L ++ EAL+ + E R
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 481 DLKLKAQ------------ESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL 528
+ LKA+ +++ + + + LE +E+ ++EL + K L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 529 KTQLYAALQQIEN---LRKELNDVLTKRALQEEELHSKEEKLRDIKSHQA---------- 575
+ + A Q E R E N+ KR + +LH E +L D + +A
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 576 ----DLELEVKNSLDTIHRLESELKKQSKIQSQMK------------------------- 606
DLEL+ ++ I E +K+ K+Q+QMK
Sbjct: 1624 GDLKDLELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680
Query: 607 ------VEKAHLEEEIAELKKSQAQ---DKAKLLE-----------MQESIKDLSAIRAD 646
+ L+E++A ++++ Q +K +L E +Q+ + L A A
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 647 LANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQ---RELKDLTSS 703
L +L EE+ +A+ + T QA+ E AT + + Q R+ K+L S
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 704 LQ----SVKTKH-------EQNIQELMKHFKKEKSEAENHIRTLKAESL----------E 742
L +VK+K E I +L + ++E E + ++LK + +
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860
Query: 743 EKNMAKIHRGQLEK-------LKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKH 795
E+ MA+ ++ Q EK LK Q + EE + +KL+ + + E +
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Query: 796 ISIEEEHLRRMEE 808
++ + LRR E
Sbjct: 1921 VNALKSKLRRGNE 1933
Score = 102 bits (253), Expect = 3e-21
Identities = 146/649 (22%), Positives = 289/649 (44%), Gaps = 115/649 (17%)
Query: 446 ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALE 505
++TR E+ + + ELQ+++ +++AE ++L+ K + + L ++L+ E
Sbjct: 846 QVTRQEEEMQAKED----ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 506 KQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEE 565
+E +E+ + +E +E+ ++ A L++ E+ ++L K A Q +L EE
Sbjct: 902 LYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EE 957
Query: 566 KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA- 624
+L + ++ + L+LE + I +LE E+ +++ E+ LEE I++L + A
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 625 -QDKAKLL----------------------------------------EMQESIKDLSAI 643
++KAK L + E I DL A
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQ---AKSRDEETATIITQL-------KLERDVH 693
A+L +LA++E +A L L D AQ A + E I+ L + R+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 694 QRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQ 753
+++ +DL L+++KT+ E + ++ +++ E + LK ++L+E+ + H Q
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLK-KALDEE--TRSHEAQ 1193
Query: 754 LEKLKSQCDRLTEELTQN------------------ENENKKLKLKYQCL---KDQLEER 792
+++++ + + EELT+ E EN L + + L K ++E +
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 793 EKHISIEEEHLRRM----EEARLQLKDQLLCLETEQESILGVI----GKEI----DAACK 840
+K + + + L+ E AR +L D++ L+ E ES+ G++ GK I D A
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 841 TFSKDSVEKLKVFSSGPDIHYDPH-RWLAESKTKLQ-WLCEELKERENREKN---LRHQL 895
+ ++L + ++ R L E + LQ L EE++ ++N E++ L QL
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 896 MLCRQQLRN-------LTENK---ESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD 945
+++L++ L E K + E++ L QQ E + D++ + K L +E
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 946 EEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSER 994
++ + + V LE Q D L + E+ ++ + D RD + R
Sbjct: 1434 VDLDNQRQLVSNLE-KKQRKFDQL--LAEEKNISSKYADERDRAEAEAR 1479
Score = 95.1 bits (235), Expect = 3e-19
Identities = 120/582 (20%), Positives = 263/582 (45%), Gaps = 76/582 (13%)
Query: 169 RDLSSEQIRLGD------DFNRELSRRSRSDAETKRALEELTEKLNEA----QKQEVVSD 218
R +S+ I+L D DF + ++ +E LT++ E K E +
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 219 RVERRLQELEREMRTERELV------ERRQDQLGL----MSLQLQEALKKQEAKADEHEG 268
R+++ L +L ++ +R+LV +R+ DQL +S + + + EA+A E E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH 328
+ R E E + ++ELE + ++L + E L+ +++ + + E ++ L+
Sbjct: 1484 KALSLARALE-EALEAKEELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 329 QVSQISKQQSNYQDE--QGEDWRFRRGV---------EREKQDLEKQMSDLRVQLN--FS 375
Q+ ++ Q +DE ED + R V ER+ Q ++Q + R QL
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 376 AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435
+ELE+ ++ K L +++L + ++ K + + + +L+++Q +
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 436 ERKHADLQISELTRHAEDATKQAERYLSELQQ-------SEALKEEAEKRREDL------ 482
E + A E+ A++ K+A+ ++L Q +E +++A+ +E+L
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719
Query: 483 ----KLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL------ 532
+ Q+ R+ + + +LE LE++ ++ ++ + + ++ ++L +L
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 533 ----YAALQQIENLRKELNDVLTK-----RALQEEELHSKEEKLRDIKSHQADLELEVKN 583
+A QQ+E KEL L + ++ + + + E K+ + + +E E +
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEARE 1836
Query: 584 SLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA---QDKAKLLEMQESIKDL 640
L+ + KK +I Q++ E+ E+ + +K A Q K +L E +E + +
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 641 SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATI 682
+A R L +L E + +A+ ++++ L ++ + R ET+ +
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLR-RGNETSFV 1937
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/273 (24%), Positives = 117/273 (42%), Gaps = 56/273 (20%)
Query: 170 DLSSEQIRLGDDFNRELSRRSRSDAETKRA---LEELTEKLNEAQ-KQEVVSDRVERRLQ 225
DL E+ L ++ LS R+ E +R + +L E+L E Q E +SDRV + Q
Sbjct: 1707 DLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 226 ELER---EMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQT----E 278
+ E+ E+ TER ++ + QL+ K+ +K E EGA+K+K + T E
Sbjct: 1765 QAEQLSNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 279 TEKNQLEQELELSRR------------------LLNQSEGSRETLLHQVEELRTQLTKAE 320
+ QLE+++E R +L Q E R+ E+ + Q K
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK----MAEQYKEQAEKGN 1876
Query: 321 GDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASE 380
+V Q+ +Q ++E RR ++RE + + + ++N A+ S+
Sbjct: 1877 A-------RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN--ALKSK 1927
Query: 381 LEEVKRCMERKDKEKAHLASQVENLTRELENGE 413
L R+ E + + S+ R +EN +
Sbjct: 1928 L--------RRGNETSFVPSRRSGGRRVIENAD 1952
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 150 bits (378), Expect = 8e-36
Identities = 191/867 (22%), Positives = 386/867 (44%), Gaps = 78/867 (8%)
Query: 184 RELSRRSRSDAETKRALEEL----TEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE 239
+EL ++ E K L+E TE EA++ V ++ L+E+ EM E E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR----QTETEKNQLEQELELSRRLL 295
R QL ++ + + E + +E E A + KL+ E + +LE E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 296 NQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVE 355
N+ R+ L ++ +L T L + E K L ++ S + ++ + R+ +E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 356 REKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ 415
+ K+ LE SD Q+ + + +++ E+K + +K++E +++++ + N K+
Sbjct: 1062 KLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 416 QLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEA 475
++ + ++Q D+ A R A+ Q +L E + E L + L+ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 476 EKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAA 535
E+ LK E R + + +++ +K ++ V+ELT + Q + K L
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 536 LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 595
++ +L EL + + E + E ++++++S +D E D +H+L++E+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEE 655
+ + + ++ + + L +++A L SQ QD +LL QE + + +++ KL + E
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASL-SSQLQDTQELL--QEETRQ----KLNVSTKLRQLE 1349
Query: 656 RAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---KTKHE 712
+ + L+D D +AK E I+ L ++ +++L+D S+++++ K + +
Sbjct: 1350 EERNS-LQDQLDEEMEAKQNLERH---ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 713 QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE 772
+ I+ L + + +EK+ A + + K +E + + +L S ++ + Q
Sbjct: 1406 KEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 773 NENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL----LCLETEQESIL 828
E K + KY +D+ E + + L R E L+ K++L L+ E E ++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 829 GV---IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE 885
+GK + K SK ++E + E KT+L+ L +EL+ E
Sbjct: 1525 SSKDDVGKNVHELEK--SKRALE----------------TQMEEMKTQLEELEDELQATE 1566
Query: 886 NREKNLRHQLMLCRQQL-RNL----TENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
+ + L + + Q R+L +N+E Q Q E + +L DE R++R L
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RKQRALAAA 1624
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLE-DFKDFRDSCSSSERTDGRY 999
++K E G L+D LE A+ E ++L L+ KDF+ E D R
Sbjct: 1625 AKKKLE--GDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQ-----RELEDARA 1673
Query: 1000 SKYRVRRNSLQHHQDDTKYRTKSFKGD 1026
S+ + + ++ + + KS + D
Sbjct: 1674 SRDEIFATAKENEK-----KAKSLEAD 1695
Score = 138 bits (348), Expect = 2e-32
Identities = 170/858 (19%), Positives = 374/858 (43%), Gaps = 104/858 (12%)
Query: 156 DDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEV 215
D++ Q + + +R+L L +D + E + R++++ + + EEL EA K E
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-----EALKTE- 1161
Query: 216 VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR 275
L++ T++EL +R+ ++ ++ L E + EA+ E +R
Sbjct: 1162 --------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--------MR 1205
Query: 276 QTETEK-NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS 334
Q + +L ++LE +R + +++TL + +L +L ++ ++H+ ++
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLN------------FSAMASELE 382
Q Q + + R R + + L+ ++ + LN ++++S+L+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
+ + ++ + ++K ++++++ L E + + Q + ++ + ++ H T + +
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 443 QISEL---TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKL---K 496
++ + E+ K+ ++ + L Q K A + E K + Q+ + +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 497 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQ 556
++L LEK+ D+L + I + + + + A E KE + RAL
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARAL- 1499
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEE 615
EE L +KEE R K +A++E ++ +S D + + EL+K + +++QM+ K LEE
Sbjct: 1500 EEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK- 673
EL QA + AK L ++ +++ L DL + + E ++ + + L + + +
Sbjct: 1559 EDEL---QATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 674 SRDEETATIITQLKLERDVHQRELK-DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENH 732
R + + KLE D+ EL+ D + K + +Q MK F++E +A
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 733 IRTLKAESLEEKNMAKIHRGQL----------EKLKSQCDRLTEELTQN----------- 771
+ A + E + AK L E+ + Q D EEL +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 772 ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLC------------ 819
++E ++L+ + L+++LEE + ++ + +R+ + QL ++L
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 820 --LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL 877
LE + + + + E++ A K+ K ++ L+ + + + ++ TK
Sbjct: 1795 QQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---- 1849
Query: 878 CEELKERENREKNLRHQL---MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
LK+++ + K + Q+ +Q + E + ++ L +Q+E E+ I+ +
Sbjct: 1850 --SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 935 RDL---LEETQRKDEEMG 949
R L L+E +E MG
Sbjct: 1908 RKLQRELDEATESNEAMG 1925
Score = 125 bits (315), Expect = 2e-28
Identities = 166/793 (20%), Positives = 334/793 (42%), Gaps = 151/793 (19%)
Query: 154 ETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKR-----ALEELTEKLN 208
E +D Q LR +++ + E +R + + R A+EELTE+L
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268
+ ++ + D+ ++ L++ ++ E ++ + + ++ +L+ +++ ++K + E
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEG------- 321
A + + ++L+ E+E +LN++EG L V L +QL +
Sbjct: 1281 A----RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 322 DRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQL-NFSAMASE 380
+ + ++ Q+ +++++ QD+ E+ ++ +ER L Q+SD + +L +F++
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 381 LEEVKRCMERK------------------DKEKAHLASQVENLTRELENGEKQQLQMLDR 422
LEE K+ +++ +K K L ++++L +L+N Q Q++
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQLVSN 1452
Query: 423 LKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS--EALKEEAEKRRE 480
L++ Q FD AE K+ + ++ AE ++ E L ++ EAL+ + E R
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 481 DLKLKAQ------------ESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL 528
+ LKA+ +++ + + + LE +E+ ++EL + K L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 529 KTQLYAALQQIEN---LRKELNDVLTKRALQEEELHSKEEKLRDIKSHQA---------- 575
+ + A Q E R E N+ KR + +LH E +L D + +A
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNE--EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 576 ----DLELEVKNSLDTIHRLESELKKQSKIQSQMK------------------------- 606
DLEL+ ++ I E +K+ K+Q+QMK
Sbjct: 1631 GDLKDLELQADSA---IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687
Query: 607 ------VEKAHLEEEIAELKKSQAQ---DKAKLLE-----------MQESIKDLSAIRAD 646
+ L+E++A ++++ Q +K +L E +Q+ + L A A
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 647 LANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQ---RELKDLTSS 703
L +L EE+ +A+ + T QA+ E AT + + Q R+ K+L S
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 704 LQ----SVKTKH-------EQNIQELMKHFKKEKSEAENHIRTLKAESL----------E 742
L +VK+K E I +L + ++E E + ++LK + +
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867
Query: 743 EKNMAKIHRGQLEK-------LKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKH 795
E+ MA+ ++ Q EK LK Q + EE + +KL+ + + E +
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Query: 796 ISIEEEHLRRMEE 808
++ + LRR E
Sbjct: 1928 VNALKSKLRRGNE 1940
Score = 102 bits (253), Expect = 3e-21
Identities = 146/649 (22%), Positives = 289/649 (44%), Gaps = 115/649 (17%)
Query: 446 ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALE 505
++TR E+ + + ELQ+++ +++AE ++L+ K + + L ++L+ E
Sbjct: 853 QVTRQEEEMQAKED----ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 506 KQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEE 565
+E +E+ + +E +E+ ++ A L++ E+ ++L K A Q +L EE
Sbjct: 909 LYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EE 964
Query: 566 KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA- 624
+L + ++ + L+LE + I +LE E+ +++ E+ LEE I++L + A
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 625 -QDKAKLL----------------------------------------EMQESIKDLSAI 643
++KAK L + E I DL A
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQ---AKSRDEETATIITQL-------KLERDVH 693
A+L +LA++E +A L L D AQ A + E I+ L + R+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 694 QRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQ 753
+++ +DL L+++KT+ E + ++ +++ E + LK ++L+E+ + H Q
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLK-KALDEE--TRSHEAQ 1200
Query: 754 LEKLKSQCDRLTEELTQN------------------ENENKKLKLKYQCL---KDQLEER 792
+++++ + + EELT+ E EN L + + L K ++E +
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 793 EKHISIEEEHLRRM----EEARLQLKDQLLCLETEQESILGVI----GKEI----DAACK 840
+K + + + L+ E AR +L D++ L+ E ES+ G++ GK I D A
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 841 TFSKDSVEKLKVFSSGPDIHYDPH-RWLAESKTKLQ-WLCEELKERENREKN---LRHQL 895
+ ++L + ++ R L E + LQ L EE++ ++N E++ L QL
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 896 MLCRQQLRN-------LTENK---ESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD 945
+++L++ L E K + E++ L QQ E + D++ + K L +E
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 946 EEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSER 994
++ + + V LE Q D L + E+ ++ + D RD + R
Sbjct: 1441 VDLDNQRQLVSNLE-KKQRKFDQL--LAEEKNISSKYADERDRAEAEAR 1486
Score = 95.1 bits (235), Expect = 3e-19
Identities = 120/582 (20%), Positives = 263/582 (45%), Gaps = 76/582 (13%)
Query: 169 RDLSSEQIRLGD------DFNRELSRRSRSDAETKRALEELTEKLNEA----QKQEVVSD 218
R +S+ I+L D DF + ++ +E LT++ E K E +
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 219 RVERRLQELEREMRTERELV------ERRQDQLGL----MSLQLQEALKKQEAKADEHEG 268
R+++ L +L ++ +R+LV +R+ DQL +S + + + EA+A E E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH 328
+ R E E + ++ELE + ++L + E L+ +++ + + E ++ L+
Sbjct: 1491 KALSLARALE-EALEAKEELERTNKML---KAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 329 QVSQISKQQSNYQDE--QGEDWRFRRGV---------EREKQDLEKQMSDLRVQLN--FS 375
Q+ ++ Q +DE ED + R V ER+ Q ++Q + R QL
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 376 AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435
+ELE+ ++ K L +++L + ++ K + + + +L+++Q +
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 436 ERKHADLQISELTRHAEDATKQAERYLSELQQ-------SEALKEEAEKRREDL------ 482
E + A E+ A++ K+A+ ++L Q +E +++A+ +E+L
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726
Query: 483 ----KLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL------ 532
+ Q+ R+ + + +LE LE++ ++ ++ + + ++ ++L +L
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 533 ----YAALQQIENLRKELNDVLTK-----RALQEEELHSKEEKLRDIKSHQADLELEVKN 583
+A QQ+E KEL L + ++ + + + E K+ + + +E E +
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEARE 1843
Query: 584 SLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA---QDKAKLLEMQESIKDL 640
L+ + KK +I Q++ E+ E+ + +K A Q K +L E +E + +
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 641 SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATI 682
+A R L +L E + +A+ ++++ L ++ + R ET+ +
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLR-RGNETSFV 1944
Score = 54.7 bits (130), Expect = 5e-07
Identities = 67/273 (24%), Positives = 117/273 (42%), Gaps = 56/273 (20%)
Query: 170 DLSSEQIRLGDDFNRELSRRSRSDAETKRA---LEELTEKLNEAQ-KQEVVSDRVERRLQ 225
DL E+ L ++ LS R+ E +R + +L E+L E Q E +SDRV + Q
Sbjct: 1714 DLEKEE--LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 226 ELER---EMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQT----E 278
+ E+ E+ TER ++ + QL+ K+ +K E EGA+K+K + T E
Sbjct: 1772 QAEQLSNELATERSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 279 TEKNQLEQELELSRR------------------LLNQSEGSRETLLHQVEELRTQLTKAE 320
+ QLE+++E R +L Q E R+ E+ + Q K
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK----MAEQYKEQAEKGN 1883
Query: 321 GDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASE 380
+V Q+ +Q ++E RR ++RE + + + ++N A+ S+
Sbjct: 1884 A-------RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN--ALKSK 1934
Query: 381 LEEVKRCMERKDKEKAHLASQVENLTRELENGE 413
L R+ E + + S+ R +EN +
Sbjct: 1935 L--------RRGNETSFVPSRRSGGRRVIENAD 1959
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 150 bits (378), Expect = 8e-36
Identities = 191/867 (22%), Positives = 386/867 (44%), Gaps = 78/867 (8%)
Query: 184 RELSRRSRSDAETKRALEEL----TEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE 239
+EL ++ E K L+E TE EA++ V ++ L+E+ EM E E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR----QTETEKNQLEQELELSRRLL 295
R QL ++ + + E + +E E A + KL+ E + +LE E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 296 NQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVE 355
N+ R+ L ++ +L T L + E K L ++ S + ++ + R+ +E
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 356 REKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ 415
+ K+ LE SD Q+ + + +++ E+K + +K++E +++++ + N K+
Sbjct: 1062 KLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 416 QLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEA 475
++ + ++Q D+ A R A+ Q +L E + E L + L+ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 476 EKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAA 535
E+ LK E R + + +++ +K ++ V+ELT + Q + K L
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 536 LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 595
++ +L EL + + E + E ++++++S +D E D +H+L++E+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEE 655
+ + + ++ + + L +++A L SQ QD +LL QE + + +++ KL + E
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASL-SSQLQDTQELL--QEETRQ----KLNVSTKLRQLE 1349
Query: 656 RAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---KTKHE 712
+ + L+D D +AK E I+ L ++ +++L+D S+++++ K + +
Sbjct: 1350 EERNS-LQDQLDEEMEAKQNLERH---ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 713 QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE 772
+ I+ L + + +EK+ A + + K +E + + +L S ++ + Q
Sbjct: 1406 KEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 773 NENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL----LCLETEQESIL 828
E K + KY +D+ E + + L R E L+ K++L L+ E E ++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 829 GV---IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE 885
+GK + K SK ++E + E KT+L+ L +EL+ E
Sbjct: 1525 SSKDDVGKNVHELEK--SKRALE----------------TQMEEMKTQLEELEDELQATE 1566
Query: 886 NREKNLRHQLMLCRQQL-RNL----TENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
+ + L + + Q R+L +N+E Q Q E + +L DE R++R L
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RKQRALAAA 1624
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLE-DFKDFRDSCSSSERTDGRY 999
++K E G L+D LE A+ E ++L L+ KDF+ E D R
Sbjct: 1625 AKKKLE--GDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQ-----RELEDARA 1673
Query: 1000 SKYRVRRNSLQHHQDDTKYRTKSFKGD 1026
S+ + + ++ + + KS + D
Sbjct: 1674 SRDEIFATAKENEK-----KAKSLEAD 1695
Score = 138 bits (348), Expect = 2e-32
Identities = 170/858 (19%), Positives = 374/858 (43%), Gaps = 104/858 (12%)
Query: 156 DDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEV 215
D++ Q + + +R+L L +D + E + R++++ + + EEL EA K E
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-----EALKTE- 1161
Query: 216 VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR 275
L++ T++EL +R+ ++ ++ L E + EA+ E +R
Sbjct: 1162 --------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--------MR 1205
Query: 276 QTETEK-NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS 334
Q + +L ++LE +R + +++TL + +L +L ++ ++H+ ++
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLN------------FSAMASELE 382
Q Q + + R R + + L+ ++ + LN ++++S+L+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
+ + ++ + ++K ++++++ L E + + Q + ++ + ++ H T + +
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 443 QISEL---TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKL---K 496
++ + E+ K+ ++ + L Q K A + E K + Q+ + +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 497 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQ 556
++L LEK+ D+L + I + + + + A E KE + RAL
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARAL- 1499
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEE 615
EE L +KEE R K +A++E ++ +S D + + EL+K + +++QM+ K LEE
Sbjct: 1500 EEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK- 673
EL QA + AK L ++ +++ L DL + + E ++ + + L + + +
Sbjct: 1559 EDEL---QATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 674 SRDEETATIITQLKLERDVHQRELK-DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENH 732
R + + KLE D+ EL+ D + K + +Q MK F++E +A
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 733 IRTLKAESLEEKNMAKIHRGQL----------EKLKSQCDRLTEELTQN----------- 771
+ A + E + AK L E+ + Q D EEL +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 772 ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLC------------ 819
++E ++L+ + L+++LEE + ++ + +R+ + QL ++L
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 820 --LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL 877
LE + + + + E++ A K+ K ++ L+ + + + ++ TK
Sbjct: 1795 QQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---- 1849
Query: 878 CEELKERENREKNLRHQL---MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
LK+++ + K + Q+ +Q + E + ++ L +Q+E E+ I+ +
Sbjct: 1850 --SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 935 RDL---LEETQRKDEEMG 949
R L L+E +E MG
Sbjct: 1908 RKLQRELDEATESNEAMG 1925
Score = 102 bits (253), Expect = 3e-21
Identities = 146/649 (22%), Positives = 289/649 (44%), Gaps = 115/649 (17%)
Query: 446 ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALE 505
++TR E+ + + ELQ+++ +++AE ++L+ K + + L ++L+ E
Sbjct: 853 QVTRQEEEMQAKED----ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 506 KQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEE 565
+E +E+ + +E +E+ ++ A L++ E+ ++L K A Q +L EE
Sbjct: 909 LYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EE 964
Query: 566 KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA- 624
+L + ++ + L+LE + I +LE E+ +++ E+ LEE I++L + A
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 625 -QDKAKLL----------------------------------------EMQESIKDLSAI 643
++KAK L + E I DL A
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQ---AKSRDEETATIITQL-------KLERDVH 693
A+L +LA++E +A L L D AQ A + E I+ L + R+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 694 QRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQ 753
+++ +DL L+++KT+ E + ++ +++ E + LK ++L+E+ + H Q
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLK-KALDEE--TRSHEAQ 1200
Query: 754 LEKLKSQCDRLTEELTQN------------------ENENKKLKLKYQCL---KDQLEER 792
+++++ + + EELT+ E EN L + + L K ++E +
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 793 EKHISIEEEHLRRM----EEARLQLKDQLLCLETEQESILGVI----GKEI----DAACK 840
+K + + + L+ E AR +L D++ L+ E ES+ G++ GK I D A
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 841 TFSKDSVEKLKVFSSGPDIHYDPH-RWLAESKTKLQ-WLCEELKERENREKN---LRHQL 895
+ ++L + ++ R L E + LQ L EE++ ++N E++ L QL
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 896 MLCRQQLRN-------LTENK---ESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD 945
+++L++ L E K + E++ L QQ E + D++ + K L +E
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 946 EEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSER 994
++ + + V LE Q D L + E+ ++ + D RD + R
Sbjct: 1441 VDLDNQRQLVSNLE-KKQRKFDQL--LAEEKNISSKYADERDRAEAEAR 1486
Score = 85.9 bits (211), Expect = 2e-16
Identities = 133/641 (20%), Positives = 263/641 (41%), Gaps = 122/641 (19%)
Query: 35 VEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQR 94
+++ + V +++S LQDT L++ R + + + +E + SL+ DQL +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEET----RQKLNVSTKLRQLEEERNSLQ---DQLDEEM 1363
Query: 95 LLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRS--------- 145
+ + R IS ++ SD + +L F T + G + K + +
Sbjct: 1364 EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 146 -------RTGVRFVQETDDMT-QLHGFHQSLRDLSSEQIR----LGDDFN---RELSRRS 190
+T R QE DD+ L Q + +L +Q + L ++ N + R
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 191 RSDAETK----------RALEEL---------TEKLNEAQKQEVVS--DRVERRLQELER 229
R++AE + RALEE T K+ +A+ +++VS D V + + ELE+
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 230 EMRTERELVERRQDQLGLMSLQLQ-------------EALKKQ-EAKADEHEGAIKNKLR 275
R +E + QL + +LQ +ALK Q E + + K R
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q + + ++ E ELE R+ + +++ L +++L Q A R+ Q+ ++
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 336 QQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEK 395
Q ++Q E + R + ++ EK+ L L + +L +R ++ D EK
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEK 1717
Query: 396 AHLASQVENLT--RELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
LA ++ + R EK++L+ R+ +++ + + + ++ + T+ AE
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEA--RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 454 ATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDE 513
+ + S Q++E+ +++ E++ ++L+ K E K K K ALE + ++E
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 514 LTGKN-------NQILKEKD--------------------------------ELKTQLYA 534
+ + LK+KD +LK QL
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 535 ALQQIEN-------LRKELNDVLTKRALQEEELHSKEEKLR 568
A ++ + L++EL++ E+++ + KLR
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 150 bits (378), Expect = 8e-36
Identities = 191/867 (22%), Positives = 386/867 (44%), Gaps = 78/867 (8%)
Query: 184 RELSRRSRSDAETKRALEEL----TEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE 239
+EL ++ E K L+E TE EA++ V ++ L+E+ EM E E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR----QTETEKNQLEQELELSRRLL 295
R QL ++ + + E + +E E A + KL+ E + +LE E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 296 NQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVE 355
N+ R+ L ++ +L T L + E K L ++ S + ++ + R+ +E
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 356 REKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ 415
+ K+ LE SD Q+ + + +++ E+K + +K++E +++++ + N K+
Sbjct: 1055 KLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 416 QLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEA 475
++ + ++Q D+ A R A+ Q +L E + E L + L+ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 476 EKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAA 535
E+ LK E R + + +++ +K ++ V+ELT + Q + K L
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 536 LQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 595
++ +L EL + + E + E ++++++S +D E D +H+L++E+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEE 655
+ + + ++ + + L +++A L SQ QD +LL QE + + +++ KL + E
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASL-SSQLQDTQELL--QEETRQ----KLNVSTKLRQLE 1342
Query: 656 RAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---KTKHE 712
+ + L+D D +AK E I+ L ++ +++L+D S+++++ K + +
Sbjct: 1343 EERNS-LQDQLDEEMEAKQNLERH---ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 713 QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE 772
+ I+ L + + +EK+ A + + K +E + + +L S ++ + Q
Sbjct: 1399 KEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 773 NENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL----LCLETEQESIL 828
E K + KY +D+ E + + L R E L+ K++L L+ E E ++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 829 GV---IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE 885
+GK + K SK ++E + E KT+L+ L +EL+ E
Sbjct: 1518 SSKDDVGKNVHELEK--SKRALE----------------TQMEEMKTQLEELEDELQATE 1559
Query: 886 NREKNLRHQLMLCRQQL-RNL----TENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
+ + L + + Q R+L +N+E Q Q E + +L DE R++R L
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RKQRALAAA 1617
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLE-DFKDFRDSCSSSERTDGRY 999
++K E G L+D LE A+ E ++L L+ KDF+ E D R
Sbjct: 1618 AKKKLE--GDLKD----LELQADSAIKGREEAIKQLRKLQAQMKDFQ-----RELEDARA 1666
Query: 1000 SKYRVRRNSLQHHQDDTKYRTKSFKGD 1026
S+ + + ++ + + KS + D
Sbjct: 1667 SRDEIFATAKENEK-----KAKSLEAD 1688
Score = 138 bits (348), Expect = 2e-32
Identities = 170/858 (19%), Positives = 374/858 (43%), Gaps = 104/858 (12%)
Query: 156 DDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEV 215
D++ Q + + +R+L L +D + E + R++++ + + EEL EA K E
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-----EALKTE- 1154
Query: 216 VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLR 275
L++ T++EL +R+ ++ ++ L E + EA+ E +R
Sbjct: 1155 --------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--------MR 1198
Query: 276 QTETEK-NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS 334
Q + +L ++LE +R + +++TL + +L +L ++ ++H+ ++
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLN------------FSAMASELE 382
Q Q + + R R + + L+ ++ + LN ++++S+L+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
+ + ++ + ++K ++++++ L E + + Q + ++ + ++ H T + +
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 443 QISEL---TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKL---K 496
++ + E+ K+ ++ + L Q K A + E K + Q+ + +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 497 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQ 556
++L LEK+ D+L + I + + + + A E KE + RAL
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARAL- 1492
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEE 615
EE L +KEE R K +A++E ++ +S D + + EL+K + +++QM+ K LEE
Sbjct: 1493 EEALEAKEELERTNKMLKAEME-DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK- 673
EL QA + AK L ++ +++ L DL + + E ++ + + L + + +
Sbjct: 1552 EDEL---QATEDAK-LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 674 SRDEETATIITQLKLERDVHQRELK-DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENH 732
R + + KLE D+ EL+ D + K + +Q MK F++E +A
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 733 IRTLKAESLEEKNMAKIHRGQL----------EKLKSQCDRLTEELTQN----------- 771
+ A + E + AK L E+ + Q D EEL +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 772 ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLC------------ 819
++E ++L+ + L+++LEE + ++ + +R+ + QL ++L
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 820 --LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL 877
LE + + + + E++ A K+ K ++ L+ + + + ++ TK
Sbjct: 1788 QQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK---- 1842
Query: 878 CEELKERENREKNLRHQL---MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
LK+++ + K + Q+ +Q + E + ++ L +Q+E E+ I+ +
Sbjct: 1843 --SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 935 RDL---LEETQRKDEEMG 949
R L L+E +E MG
Sbjct: 1901 RKLQRELDEATESNEAMG 1918
Score = 102 bits (253), Expect = 3e-21
Identities = 146/649 (22%), Positives = 289/649 (44%), Gaps = 115/649 (17%)
Query: 446 ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALE 505
++TR E+ + + ELQ+++ +++AE ++L+ K + + L ++L+ E
Sbjct: 846 QVTRQEEEMQAKED----ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 506 KQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEE 565
+E +E+ + +E +E+ ++ A L++ E+ ++L K A Q +L EE
Sbjct: 902 LYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EE 957
Query: 566 KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA- 624
+L + ++ + L+LE + I +LE E+ +++ E+ LEE I++L + A
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 625 -QDKAKLL----------------------------------------EMQESIKDLSAI 643
++KAK L + E I DL A
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQ---AKSRDEETATIITQL-------KLERDVH 693
A+L +LA++E +A L L D AQ A + E I+ L + R+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 694 QRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQ 753
+++ +DL L+++KT+ E + ++ +++ E + LK ++L+E+ + H Q
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLK-KALDEE--TRSHEAQ 1193
Query: 754 LEKLKSQCDRLTEELTQN------------------ENENKKLKLKYQCL---KDQLEER 792
+++++ + + EELT+ E EN L + + L K ++E +
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 793 EKHISIEEEHLRRM----EEARLQLKDQLLCLETEQESILGVI----GKEI----DAACK 840
+K + + + L+ E AR +L D++ L+ E ES+ G++ GK I D A
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 841 TFSKDSVEKLKVFSSGPDIHYDPH-RWLAESKTKLQ-WLCEELKERENREKN---LRHQL 895
+ ++L + ++ R L E + LQ L EE++ ++N E++ L QL
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 896 MLCRQQLRN-------LTENK---ESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD 945
+++L++ L E K + E++ L QQ E + D++ + K L +E
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 946 EEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSER 994
++ + + V LE Q D L + E+ ++ + D RD + R
Sbjct: 1434 VDLDNQRQLVSNLE-KKQRKFDQL--LAEEKNISSKYADERDRAEAEAR 1479
Score = 85.9 bits (211), Expect = 2e-16
Identities = 133/641 (20%), Positives = 263/641 (41%), Gaps = 122/641 (19%)
Query: 35 VEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQR 94
+++ + V +++S LQDT L++ R + + + +E + SL+ DQL +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEET----RQKLNVSTKLRQLEEERNSLQ---DQLDEEM 1356
Query: 95 LLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRS--------- 145
+ + R IS ++ SD + +L F T + G + K + +
Sbjct: 1357 EAKQNLERHISTLNIQLSD----SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 146 -------RTGVRFVQETDDMT-QLHGFHQSLRDLSSEQIR----LGDDFN---RELSRRS 190
+T R QE DD+ L Q + +L +Q + L ++ N + R
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 191 RSDAETK----------RALEEL---------TEKLNEAQKQEVVS--DRVERRLQELER 229
R++AE + RALEE T K+ +A+ +++VS D V + + ELE+
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 230 EMRTERELVERRQDQLGLMSLQLQ-------------EALKKQ-EAKADEHEGAIKNKLR 275
R +E + QL + +LQ +ALK Q E + + K R
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q + + ++ E ELE R+ + +++ L +++L Q A R+ Q+ ++
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 336 QQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEK 395
Q ++Q E + R + ++ EK+ L L + +L +R ++ D EK
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEK 1710
Query: 396 AHLASQVENLT--RELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
LA ++ + R EK++L+ R+ +++ + + + ++ + T+ AE
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEA--RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 454 ATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDE 513
+ + S Q++E+ +++ E++ ++L+ K E K K K ALE + ++E
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 514 LTGKN-------NQILKEKD--------------------------------ELKTQLYA 534
+ + LK+KD +LK QL
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 535 ALQQIEN-------LRKELNDVLTKRALQEEELHSKEEKLR 568
A ++ + L++EL++ E+++ + KLR
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 147 bits (372), Expect = 4e-35
Identities = 204/978 (20%), Positives = 408/978 (41%), Gaps = 171/978 (17%)
Query: 162 HGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVE 221
H +++LS E L ++ ++ + ++ L++L + ++ ++ ++E
Sbjct: 973 HATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLE 1032
Query: 222 RRLQELEREMRTEREL---VER---------RQDQLGLMSL-----QLQEALKKQE---- 260
++ +LE + E++L +ER + Q +M L Q++E LKK+E
Sbjct: 1033 QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 261 ---AKADE---HEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
AK D+ H + K+++ + +LE+E+E L + E R L ++EE+
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE 1152
Query: 315 QLTKAEG-----------------------DRKGLQHQ--VSQISKQQSNYQDEQGEDWR 349
+L +A G + LQH+ + + K+Q++ E GE
Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ-- 1210
Query: 350 FRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTREL 409
++R KQ LEK+ S+L+++++ MAS +E + + ++ VE+ E+
Sbjct: 1211 -IDNLQRVKQKLEKEKSELKMEID--DMASNIEALSKSKSNIER----TCRTVEDQFSEI 1263
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ ++QQ Q++ L + T E H ++ E TK + +L++ +
Sbjct: 1264 KAKDEQQTQLIHDLNMQKARLQTQNGELSH---RVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 470 ALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELK 529
EE K + + Q S L ++ E E ++E L+ N+++ + + + +
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 530 TQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSH-QADLELEVKNSLDTI 588
T +++E +K+L L + E +SK L K Q ++E ++ L+
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE-DLMRDLERS 1439
Query: 589 HRLESEL-KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE--------------- 632
H + L KKQ + K L+E AEL+ +Q + ++ E
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 633 ---------MQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL-----TAQAKSRDEE 678
+QE I DL+ A+ L E E+ KK V ++ SDL + EE
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 679 TATIITQLKL------------ERDVHQRELK----DLTSSLQSV--------------K 708
+ + QL+L E+D +LK +LQSV K
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK 1619
Query: 709 TKHEQNIQEL---MKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLT 765
K E ++ E+ + H ++ +E + H+RT++ + LK L
Sbjct: 1620 KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ-----------------LKDSQLHLD 1662
Query: 766 EELTQNENENKKLKL---KYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLET 822
+ L NE+ ++L + + L ++LEE + + E R E+ L D++ L +
Sbjct: 1663 DALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 823 EQESILGVIGK-EID-AACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEE 880
+ S++ K E D A C+ ++S+++ + + ++ T + EE
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESR----------NAEEKAKKAITDAAMMAEE 1772
Query: 881 LKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
LK+ ++ +L Q +++L + Q + ++Q Q L+ RE + L+
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 941 TQRKDEE--MGSLQDRVIALETSTQVALDH-----LESVPEKL-SLLEDFKDFRDSCSSS 992
Q++ E G+ + E + Q DH L+ + +KL + ++ +K R + +
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK--RQAEEAE 1890
Query: 993 ERTDGRYSKYRVRRNSLQ 1010
E+ + + S+ R ++ L+
Sbjct: 1891 EQANTQLSRCRRVQHELE 1908
Score = 133 bits (335), Expect = 8e-31
Identities = 190/895 (21%), Positives = 379/895 (42%), Gaps = 126/895 (14%)
Query: 170 DLSSEQIRLGDDFNRELSRRSRSDAETKRALEEL-----------------TEKLNEAQK 212
+ E + +DF R +RS+A K E++ TE L +A++
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 213 --------QEVVSDRVERRLQELEREMRTERELVERR---QDQLGLMSLQLQEALKKQEA 261
+ ++ +V+ + LE E ELV ++ +D+ + + + L+
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD-LELTLT 966
Query: 262 KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEG 321
K ++ + A +NK++ E LE+ + +L + + +E +++L+ + K
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENIS---KLTKEKKSLQEAHQQTLDDLQVEEDKV-- 1021
Query: 322 DRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
GL +++ +Q + + ++ + R +ER K+ LE DL++ +L
Sbjct: 1022 --NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE---GDLKMS---QESIMDL 1073
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAE----- 436
E K+ +E K K+K SQ L ++++ + LQ ++KE+Q + E E
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQ---LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130
Query: 437 --RKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWK 494
R + Q S+L R E+ +++ L E + + + E K+RE K + + +
Sbjct: 1131 TLRAKIEKQRSDLARELEEISER----LEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 495 LKHKKLERALEKQ--------SETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
L+H+ L K+ E +D L ++ KEK ELK ++ IE L K
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSK 1246
Query: 547 NDV-LTKRALQEE--ELHSKEEK----LRDIKSHQADLELEVKNSLDTIHRLESELKKQS 599
+++ T R ++++ E+ +K+E+ + D+ +A L+ + + + HR+E +K+S
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ---NGELSHRVE---EKES 1300
Query: 600 KIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKK 659
I SQ+ K L +++ ELK+ Q +++ K S DL + EEE+ K
Sbjct: 1301 LI-SQLTKSKQALTQQLEELKR-QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 660 AVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELM 719
A +L ++A S + T K E D QR T L+ K K Q +QE
Sbjct: 1359 A---ELQRALSKANSEVAQWRT-----KYETDAIQR-----TEELEEAKKKLAQRLQEAE 1405
Query: 720 KHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLK 779
++ + S+ + +T + E +++ + LE+ + C L ++ + + K
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLMR----DLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 780 LKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAAC 839
K + +LE +K L +M A ++ DQL L E +++ I +
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 840 KTFSK-DSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEE----LKERENREKNLRHQ 894
+T EK K + + + K+ LQ EE L+ E++ ++ +
Sbjct: 1522 ETGKNLQEAEKTK-------------KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLE 1568
Query: 895 LMLCRQQLRNLTENKESELQCLFQQIERQ----EQLLDEIHREKRDLLEETQRKDEEMGS 950
L + +L K+ E++ L + +R + +LD R + D L ++ + ++
Sbjct: 1569 LSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE 1628
Query: 951 LQDRVIALETSTQVALDHLESVPEKL--------SLLEDFKDFRDSCSSSERTDG 997
++ ++ HL +V +L L +D ++ + ER +G
Sbjct: 1629 MEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNG 1683
Score = 114 bits (285), Expect = 5e-25
Identities = 155/739 (20%), Positives = 330/739 (44%), Gaps = 82/739 (11%)
Query: 294 LLNQSEGSRE--TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFR 351
LL +E +E T+ E + +L ++E RK L+ ++ + +++++ Q + +
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 352 RGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELEN 411
E + L K S + ++ + LEE + +K +L + +L R++++
Sbjct: 903 MDAEERCEGLIK--SKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD 960
Query: 412 GEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE-- 469
E ++ +N E + IS+LT+ + + ++ L +LQ E
Sbjct: 961 LELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK 1020
Query: 470 -----ALKEEAEKRREDLK--LKAQESIR-QWKLKHKKLERALEKQSETVDELTGKNNQI 521
+ + E++ +DL+ L+ ++ +R + +KLE L+ E++ +L QI
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080
Query: 522 ---LKEKDELKTQLYAAL--QQIENL--RKELNDVLTKRALQEEELHSKEEKLRDIKSHQ 574
LK+K+ +QL A + +Q+ +L +K++ ++ + EEE+ ++ I+ +
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR 1140
Query: 575 ADLELEVKN--------SLDTIHRLESELKKQSKIQSQMK-VEKAHLEEE--IAELKKSQ 623
+DL E++ S T ++E K++++ Q + +E+A L+ E A L+K Q
Sbjct: 1141 SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQ 1200
Query: 624 AQDKAKLLEMQESI--------KDLSAIRADLANKLAEEERAKKA------VLKDLSDLT 669
A A+L E +++ K+ S ++ ++ + + E K+ + + D
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 670 AQAKSRDEETATIITQLKLERDVHQRELKDLT------SSLQSVKTKHEQNIQELMKHFK 723
++ K++DE+ +I L +++ Q + +L+ SL S TK +Q + + ++ K
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 724 KEKSEAENHIRTLKAESLE-EKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
++ E E + A +L+ ++ + R Q E+ + L L++ +E + + KY
Sbjct: 1321 RQMEE-ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY 1379
Query: 783 QC----LKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIG------ 832
+ ++LEE +K ++ + L+ EE + LE ++ + G +
Sbjct: 1380 ETDAIQRTEELEEAKKKLA---QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 833 KEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLR 892
+ AC T K KV + + L ++ + + L EL + N + +
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 893 HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQ 952
QL R++ +NL E E+ L +QI + L E + K+ L E ++ D +
Sbjct: 1497 DQLETLRRENKNLQE----EISDLTEQIAETGKNLQEAEKTKK--LVEQEKSDLQ----- 1545
Query: 953 DRVIALETSTQVALDHLES 971
+ALE + +L+H ES
Sbjct: 1546 ---VALE-EVEGSLEHEES 1560
Score = 85.1 bits (209), Expect = 3e-16
Identities = 119/547 (21%), Positives = 234/547 (42%), Gaps = 100/547 (18%)
Query: 522 LKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEV 581
L + E + ++ + E ++EL +R EE++ S ++ D+ Q ++ E
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDL---QLQVQSET 899
Query: 582 KNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLS 641
+N +D R E +K + +++++K LEEE ++ ++ AK +++ L
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEEE----EEMNSELVAKKRNLEDKCSSLK 955
Query: 642 AIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDL- 700
DL L + E+ K A + +L+ + + +E + + + K ++ HQ+ L DL
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 701 -----TSSLQSVKTKHEQNIQEL---MKHFKKEKSEAENHIRTLKA-------------- 738
+ L + K EQ +L ++ KK +++ E R L+
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 739 --ESLEEKNMAK---------------IHRGQLEK----LKSQCDRLTEELTQNENENKK 777
+ +EEK K +H Q +K L+++ + L EE+ K
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK 1135
Query: 778 LKLKYQCLKDQLE-----------------EREKHISIEEEHLRR-MEEARLQLKDQLLC 819
++ + L +LE E K E + +RR +EEA LQ +
Sbjct: 1136 IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 820 LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLC- 878
L +Q + +G++ID + K EK ++ D+ + L++SK+ ++ C
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA-LSKSKSNIERTCR 1254
Query: 879 ------EELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHR 932
E+K ++ ++ L H L + Q+ R T+N E L ++E +E L+ ++ +
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNM--QKARLQTQNGE-----LSHRVEEKESLISQLTK 1307
Query: 933 EKRDL---LEETQRKDEEMGSLQDRVIALETSTQVALDH-LESVPEKLSLL-EDFKDFRD 987
K+ L LEE +R+ EE ET + A+ H L+S LL E +++ ++
Sbjct: 1308 SKQALTQQLEELKRQMEE-----------ETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 988 SCSSSER 994
+ + +R
Sbjct: 1357 AKAELQR 1363
Score = 77.4 bits (189), Expect = 7e-14
Identities = 95/513 (18%), Positives = 218/513 (42%), Gaps = 54/513 (10%)
Query: 156 DDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEE---LTEKLNEA-- 210
+ +L + R LS+E ++ + + + + E K EE LTE++ E
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525
Query: 211 --QKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268
Q+ E VE+ +L+ + +E + ++ + L+L + + + K E +
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH 328
I+ R ++ L+ L+ R N + ++ + + E+ QL +
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHS-------NR 1638
Query: 329 QVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCM 388
Q+++ K Q + + R +DL++Q++ V+ + ELEE+K +
Sbjct: 1639 QMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA--IVERRNGLLLEELEEMKVAL 1696
Query: 389 ERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
E+ ++ + ++ + + ++ Q +++ K+++ C+AE +++
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS-------- 1748
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
+Q+S +E+A+K D + A+E +++ + LER +
Sbjct: 1749 ----------------IQESRNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERMKKNLE 1791
Query: 509 ETVDELTGKNNQILKEKDEL-----KTQLYAALQQIENLRKELNDVLTKRALQE-EELHS 562
+TV +L + L E ++L K Q+ ++ L EL DV KR + + H
Sbjct: 1792 QTVKDLQHR----LDEAEQLALKGGKKQIQKLENRVRELENEL-DVEQKRGAEALKGAHK 1846
Query: 563 KEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKS 622
E K++++ + + D + +L++++K K Q++ E+A+ + +
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSY-KRQAEEAEEQANTQLSRCRRVQH 1905
Query: 623 QAQDKAKLLEMQES-IKDLSAIRADLANKLAEE 654
+ ++ A+ ++ ES + L A D+ ++ EE
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 145 bits (366), Expect = 2e-34
Identities = 188/905 (20%), Positives = 405/905 (44%), Gaps = 117/905 (12%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
+ +R+L S+ L +D E + R++++ + + EEL EA K E L+
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL-----EALKTE---------LE 1149
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEK-NQL 284
+ ++EL +R+ ++ ++ L+E K EA+ E +RQ ++ +L
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE--------MRQKHSQAVEEL 1201
Query: 285 EQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQ 344
++LE ++R+ E +++TL ++ EL ++ + +H+ ++ Q Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ--- 1258
Query: 345 GEDWRFRRGVEREKQDLEKQMSDLRVQL-NFSAMASELEEVKRCMERKDKEKAHLASQVE 403
+F G ER + +L +++ L+V+L N + + S+ + + K+ + L SQ++
Sbjct: 1259 ---VKFNEG-ERVRTELADKVTKLQVELDNVTGLLSQSDSKS---SKLTKDFSALESQLQ 1311
Query: 404 NLTRELENGEKQQLQMLDRLKEIQNHFDTC------EAERKH-ADLQISELTRHAEDATK 456
+ L+ +Q+L + +LK++++ ++ E E KH + QI+ L D K
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK 1371
Query: 457 QAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDEL-- 514
+ E + L+ +E +K + +K E L + +E + + KLE+ + + +D+L
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV----AAYDKLEKTKTRLQQELDDLLV 1427
Query: 515 ---------------TGKNNQILKEKDELKTQLYAALQ---QIENLRKELNDVLTKRALQ 556
K +Q+L E+ + + YA + + E KE + RAL
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAEEKTISAK-YAEERDRAEAEAREKETKALSLARAL- 1485
Query: 557 EEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK-IQSQMKVEKAHLEEE 615
EE + K E R K + ++E ++ +S D + + EL+K + ++ Q++ K LEE
Sbjct: 1486 EEAMEQKAELERLNKQFRTEME-DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANKLAEEERAKKAVLKDLSDLTAQAK- 673
EL QA + AK L ++ +++ + A DL + + E KK +++ + ++ A+ +
Sbjct: 1545 EDEL---QATEDAK-LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 674 SRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHI 733
R + + + + KLE D LKDL + + S ++ I++L K + + + +
Sbjct: 1601 ERKQRSMAVAARKKLEMD-----LKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDCMREL 1654
Query: 734 RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEERE 793
+A E AK + +L+ ++++ +L EEL E ++ + + L D++
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
++ E RR+E QL+++L E++ +I + A L++
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEEL----EEEQGNTELINDRLKKA----------NLQID 1760
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENK-ESE 912
D++ L S + + ER+N+E L + Q++ ++K ++
Sbjct: 1761 QINTDLN------LERSHAQKNENARQQLERQNKE------LKVKLQEMEGTVKSKYKAS 1808
Query: 913 LQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESV 972
+ L +I + E+ LD +E++ ++ +R +++ L+D ++ ++ + A + +
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK---LKDVLLQVDDERRNAEQYKDQA 1865
Query: 973 PEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEG 1032
+ + L+ K E + + R LQ +D + + + L+
Sbjct: 1866 DKASTRLKQLK------RQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
Query: 1033 SHTRG 1037
RG
Sbjct: 1920 KLRRG 1924
Score = 143 bits (360), Expect = 1e-33
Identities = 185/903 (20%), Positives = 384/903 (42%), Gaps = 113/903 (12%)
Query: 189 RSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELER-----EMRTERELVERRQD 243
+S+ AE + E+L + + E + R+ + QELE E R E E E R
Sbjct: 875 QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEE--EERCQ 932
Query: 244 QLGLMSLQLQEALKKQEAKADEHEGAIKNKLR----QTETEKNQLEQELELSRRLLNQSE 299
L ++Q+ +++ E + +E E A + KL+ TE + +LE+E + +
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESA-RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 300 GSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQ 359
++ L ++ E T LT+ E K L ++ ++ ++ + + R+ +E+ ++
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 360 DLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQM 419
LE +DL Q+ + + +++ E+K + +K++E ++VE + K+ ++
Sbjct: 1052 KLEGDSTDLSDQI--AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
Query: 420 LDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRR 479
++ E+Q ++ A R A+ Q +L E + E L + A +E KR
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE---DTLDSTAAQQELRSKRE 1166
Query: 480 EDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQI 539
+++ + + + K +++ +K S+ V+EL + L++ +K L A Q +
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA----EQLEQTKRVKANLEKAKQTL 1222
Query: 540 ENLRKEL-NDV---LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL 595
EN R EL N+V L + E + E +L++++ + E D + +L+ EL
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE--------MQESIKDLSAIRADL 647
+ + SQ + + L ++ + L +SQ QD +LL+ + +K + +
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSAL-ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 648 ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLT------ 701
+L EEE AK + K ++ L AQ ++ + L+ +V ++ KDL
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 702 -------SSLQSVKTKHEQNIQELMKHFKKEKSEAEN-------------HIRTLKAESL 741
L+ KT+ +Q + +L+ ++ A N +T+ A+
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 742 EEKNMAKI---------------------HRGQLEKLKSQCDRLTEELTQNENENKK--- 777
EE++ A+ + +LE+L Q E+L ++++ K
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 778 -LKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEID 836
L+ + L+ Q+EE + + E+ L+ E+A+L+L+ L ++ + E L + D
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL----QGRD 1577
Query: 837 AACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL--------KERENRE 888
+ K V +++ + + ++ KL+ ++L K R+
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 889 KNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQE----------QLLDEIHREKRDLL 938
K LR + +R L + + S + L Q E ++ QL +E+ +R
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 939 EETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGR 998
+ Q +DE L D + +AL+ + +++ LE+ + + ++E + R
Sbjct: 1698 QAQQERDE----LADEIANSSGKGALALEEKRRLEARIAQLEE--ELEEEQGNTELINDR 1751
Query: 999 YSK 1001
K
Sbjct: 1752 LKK 1754
Score = 126 bits (316), Expect = 1e-28
Identities = 158/707 (22%), Positives = 306/707 (43%), Gaps = 108/707 (15%)
Query: 377 MASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTC-EA 435
MA E E VK + K + +++E L +L EK QLQ +++Q + C EA
Sbjct: 848 MAKEEELVK--VREKQLAAENRLTEMETLQSQLM-AEKLQLQ-----EQLQAETELCAEA 899
Query: 436 ERKHADLQIS--ELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLK--LKAQESIR 491
E A L EL D + E Q +A K++ ++ ++L+ L+ +ES R
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 492 QWKLKHKKL--ERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV 549
Q KL+ +K+ E L+K E L +N ++ KEK L+ ++
Sbjct: 960 Q-KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE--------------- 1003
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQA---DLELEVKNSLDTIHRLESELKKQSKIQSQMK 606
T +EEE KL++ H+A DLE + + R E + ++ K + +++
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKN--KHEAMITDLE-------ERLRREEKQRQELEKTRRKLE 1054
Query: 607 VEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
+ L ++IAEL+ A+ K +L + +E ++ A ++ EE K LK +
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA-------RVEEEAAQKNMALKKIR 1107
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
+L +Q E+ + + R+ +++ +DL L+++KT+ E + ++ +
Sbjct: 1108 ELESQISELQED----LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELR 1162
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
S+ E + LK ++LEE+ AK H Q+++++ + + EEL + + K++K + K
Sbjct: 1163 SKREQEVNILK-KTLEEE--AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 787 DQLEEREKHISIE----------EEHLRRMEEARLQ---------------LKDQLLCLE 821
LE ++ E EH R+ EA+LQ L D++ L+
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 822 TEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWL---- 877
E +++ G++ + D+ +KD ++ + +R TKL+ +
Sbjct: 1280 VELDNVTGLLSQS-DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 878 ---CEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
E+L+E E + NL Q+ Q+ ++ + E + CL + +E+ R+
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL--------ETAEEVKRKL 1390
Query: 935 RDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSER 994
+ LE ++ EE + D++ +T Q LD LL D R S + E+
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD---------DLLVDLDHQRQSACNLEK 1441
Query: 995 TDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTRGLDHS 1041
++ + ++ + + R ++ ++ S R L+ +
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488
Score = 94.7 bits (234), Expect = 4e-19
Identities = 109/475 (22%), Positives = 205/475 (43%), Gaps = 62/475 (13%)
Query: 556 QEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS-KIQSQMKVE------ 608
QEEE+ +KEE+L ++ Q L +N L + L+S+L + ++Q Q++ E
Sbjct: 843 QEEEMMAKEEELVKVREKQ----LAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 609 -----------KAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERA 657
K LEE +L+ +++ + +Q K + +L +L EEE A
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 658 KKAVLKDLSDLTAQAKSRDEETATIITQ-----LKLERDVHQRELKDLTS---------- 702
++ + L +T +AK + E II + L E+ + + + + T+
Sbjct: 959 RQKL--QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 703 SLQSVKTKHE---QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKS 759
SL +K KHE +++E ++ +K++ E E R L+ +S + + + Q+ +LK
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076
Query: 760 QCDRLTEEL------TQNENENKKLKL-KYQCLKDQLEEREKHISIEEEHLRRMEEARLQ 812
Q + EEL + E K + L K + L+ Q+ E ++ + E + E+ +
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 813 LKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKT 872
L ++L L+TE E L + + K + ++ K K H + E +
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK-KTLEEEAKTH---EAQIQEMRQ 1192
Query: 873 KLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHR 932
K EEL E+ + K ++ L +Q L N +E++ L Q E ++
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252
Query: 933 EKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHL-----ESVPEKLSLLEDF 982
+ ++L + + L D+V T QV LD++ +S + L +DF
Sbjct: 1253 QLQELQVKFNEGERVRTELADKV----TKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Score = 92.8 bits (229), Expect = 2e-18
Identities = 98/467 (20%), Positives = 206/467 (44%), Gaps = 61/467 (13%)
Query: 164 FHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR 223
F + DL S + DD + + +S ++ +EE+ +
Sbjct: 1502 FRTEMEDLMSSK----DDVGKSVHELEKSKRALEQQVEEMKTQ----------------- 1540
Query: 224 LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQ 283
L+ELE E++ + R + L M Q + L+ ++ +++E K +Q + +
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE-------KKKQLVRQVRE 1593
Query: 284 LEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE 343
+E ELE R+ + + +R+ L +++L + A +R Q+ ++ Q + E
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 344 QGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVE 403
+ R + + ++ EK++ + ++ + EL +R + +E+ LA ++
Sbjct: 1654 LDDTRASREEILAQAKENEKKLKSMEAEM--IQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 404 NLTRE--LENGEKQQL-----QMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATK 456
N + + L EK++L Q+ + L+E Q + + K A+LQI ++ +
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI-----NTDL 1766
Query: 457 QAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTG 516
ER S Q++E +++ E++ ++LK+K QE K K+K ALE
Sbjct: 1767 NLER--SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE----------A 1814
Query: 517 KNNQILKEKDELKTQLYAALQQIENLRKELNDVL------TKRALQ-EEELHSKEEKLRD 569
K Q+ ++ D + AA +Q+ K+L DVL + A Q +++ +L+
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 570 IKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEI 616
+K + E E + + + +L+ EL+ ++ M E + L+ ++
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 144 bits (363), Expect = 5e-34
Identities = 212/890 (23%), Positives = 383/890 (43%), Gaps = 104/890 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAE---TKRALEE-LTEKLNEAQKQEVVSDRVERR 223
+ L+ E+ L + +R S SD E +ALE L EK A + + V +
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
Query: 224 LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQ 283
+ +E+ +R E E++Q L + E LK++E + D ++K+K+ E E
Sbjct: 2118 RRGIEK-LRVRIEADEKKQ-------LHIAEKLKEREREND----SLKDKVENLERELQM 2165
Query: 284 LEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGL--------------QHQ 329
E+ EL S+ ETL Q+EE+ L E D L Q Q
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225
Query: 330 VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLN--FSAMASELEEVKRC 387
+S++ K S+++ E + ++ E + + + + +LN +A+ + E +K
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 388 MERKD---KEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI 444
+ D +E+ L + +E L LE EK+QL +L +LKE ++H D + ++ + ++
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
Query: 445 SELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 504
+ E A +AE E++ +A E + L+L +IR K + L L
Sbjct: 2346 EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV-VTIRSEK---ENLTNEL 2401
Query: 505 EKQSETVDELTGKNN---QILKEKDELKTQL----YAALQQIENLRKELNDVLTKRALQE 557
+K+ E + EL N+ IL+EK++ K Q+ A++ ++ KELN+ + +
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 558 EELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIA 617
E +KE+ L S LELE L + + K + I Q V L +E+
Sbjct: 2462 EACKAKEQNL---SSQVECLELEKAQLLQGL-----DEAKNNYIVLQSSVN--GLIQEVE 2511
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
+ K+ + ++ ++ I+D + + L+ E + K+ L +L +LT + + + +
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL-ELRNLTVELEQKIQ 2570
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE-KSEAENHIRTL 736
+ L+ +V Q K+L + L+ K ++++ K KE + + E H
Sbjct: 2571 VLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ 2630
Query: 737 KAESLEEKNMAKIHR--GQLEKLKSQCDRLTEELTQNENENKKLKLKYQCL-KDQLEERE 793
K L+E+ + +R G+L+ L + ++L + EN +LK C+ KDQ+E+
Sbjct: 2631 KTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG 2690
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K E+ R+ EA + K Q L L+T K+ + +T+ + K +
Sbjct: 2691 KVREEIAEYQLRLHEA--EKKHQALLLDT---------NKQYEVEIQTYREKLTSKEECL 2739
Query: 854 SSGP---DIHYDPHRWLAESKTKLQWLCEELKE---------RENREKNLRHQ--LMLCR 899
SS D+ L S + EELK+ + +++N R Q + L
Sbjct: 2740 SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI 2799
Query: 900 QQLRNLTENKE---SELQCLFQQIERQ------EQLLDEIHREKRDLLEETQRKDEEMGS 950
+ + L E KE EL L E+Q + +DE+ E ++L E + K +E
Sbjct: 2800 KSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Query: 951 LQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYS 1000
D+ +L ++ + LE E L CS + D R S
Sbjct: 2860 YLDKYCSL----LISHEKLEKAKEMLE-----TQVAHLCSQQSKQDSRGS 2900
Score = 114 bits (286), Expect = 4e-25
Identities = 181/919 (19%), Positives = 368/919 (40%), Gaps = 133/919 (14%)
Query: 178 LGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTEREL 237
L + +N+E+ R R +AE K AL+ +K ++ Q ++ R ++ R +
Sbjct: 167 LKEKYNKEVEERKRLEAEVK-ALQ--AKKASQTLPQATMNHR------DIARHQASSSVF 217
Query: 238 VERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQ 297
+++ +S Q +++ A G E E L++ +R N
Sbjct: 218 SWQQEKTPSHLSSNSQRTPIRRDFSASYFSG---------EQEVTPSRSTLQIGKRDANS 268
Query: 298 SEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVERE 357
S + H +++L+ Q + L+++++++ + ++ E +G +
Sbjct: 269 SFFDNSSSPHLLDQLKAQ-------NQELRNKINELELRLQGHEKEM-------KGQVNK 314
Query: 358 KQDLEKQMSDLRVQL-----NFSAMASELEEVKRCMERKDKEKAHLASQVENLTREL--- 409
Q+L+ Q+ +V+L + EL ++ + L +++ LT +L
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 410 -ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI---------SELTRHAEDATKQAE 459
+N E + + ++KE + F E R+ Q + LT+ + A
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQE-ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 460 RYLSELQQSEALKEEAEKRREDLKLK---AQESIRQWKLKHKKLERALEKQSETVDELTG 516
+EL + ++K++ E E+ K K A+++ + ++K +L R++E+ + + L
Sbjct: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKS 493
Query: 517 KNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK---------L 567
+ Q +E L+ +L Q + + ++ K QE L +EK L
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL 553
Query: 568 RDIKSHQADLELEVKNSLDTI----HRLESELKKQSKIQSQMKVEKAHLE---EEIAELK 620
+K ADLE + S D + H +E K SK + + K + LE +E ELK
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 621 KSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETA 680
+ + E ++ + + + + +L +K+ E K T Q KS +
Sbjct: 614 EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLK---------TQQIKSHEYNER 664
Query: 681 TIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ L+++R+ E+++L + L S + E M+ +K + + H + ++
Sbjct: 665 --VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMC 722
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
L+ + GQ+E L+ + L+ E+ + + L +Y+ L+D L+ ++ + E
Sbjct: 723 LKTSQLT----GQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
Query: 801 EHLRRMEEARLQLKDQLLCLETEQESILGVIGK--EIDAACKTFSKDSVEKLKVFSSGPD 858
+H R L DQ + +I+G G + C+ + S + + + D
Sbjct: 779 DHQR-----SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 859 IHYDPHRWLAESKTKLQWLCEELKERENR-EKNL-----RHQLMLCRQQLR--------- 903
+ + LQ CEEL + + E+NL HQ + R
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Query: 904 ----------NLTENKESELQCLFQQIERQEQLLDEIHREK---RDLLEETQRKDEEMG- 949
+ ENKE ELQ L ++E ++ + E+ + D L+E Q E +
Sbjct: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
Query: 950 ---------SLQDRVIALETSTQVALDHLESV--PEKLSLLEDFKDFRDSCSSSERTDGR 998
SL R I T L + + EK++L++ + F + E++
Sbjct: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISE 1013
Query: 999 YS-KYRVRRNSLQHHQDDT 1016
S +Y+ + L ++T
Sbjct: 1014 LSDQYKQEKLILLQRCEET 1032
Score = 111 bits (278), Expect = 3e-24
Identities = 182/857 (21%), Positives = 355/857 (41%), Gaps = 130/857 (15%)
Query: 185 ELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQ 244
EL + + + + LEE +KL A++ S E L+ EM+ E L++ +Q
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 245 LGLMSLQLQEALK--------------KQEAKADEHEGAIKNKLRQTETEKNQLE-QELE 289
L+ LK + +AK E +++ + ++N L ++L+
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 290 LSRRLLNQSEGSRETLL----HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE-- 343
L+ L + + LL H +E+L +L+K E + K L + K+ ++E
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 344 -----QGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMAS-ELEEVKRCMERKDKEKAH 397
+ E+ + +E EK++L+ +++ L L + S E E R +E ++ +
Sbjct: 618 LFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE---MDREN 674
Query: 398 LASQVENLTRELENG----EKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
L+ ++ NL L++ E Q+L ++ ++ + + E ++ L+ S+LT ED
Sbjct: 675 LSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
Query: 454 ATKQAERYLSELQQSEALKEEAEKRREDLK--LKAQESIRQWKLKHKKLERALEKQ---- 507
+ + +E+ + ++ E L+ LK++++ H++ A ++Q
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 508 --------------SETVD-----ELTGKNNQILKEK-DELKTQLYAALQQIENLRKELN 547
SE + + + KN+ IL+ + D L+ L + Q +L+K+
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854
Query: 548 DVLTKRALQEEELHSKE--------EKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS 599
+++ + EE L E E + I Q D +T+ LE++ K+
Sbjct: 855 ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ 914
Query: 600 KIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKK 659
+ +++ E+A EI ELKKS LLE +S+K+L + L+ + E
Sbjct: 915 LLNDKVETEQA----EIQELKKSN-----HLLE--DSLKELQLLSETLSLEKKEMSSIIS 963
Query: 660 AVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELM 719
+++ +LT + + E A++ + + L + S + + E++I EL
Sbjct: 964 LNKREIEELTQENGTLKEINASL--------NQEKMNLIQKSESFANYIDEREKSISELS 1015
Query: 720 KHFKKEK-------SEAENHIRTL--KAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770
+K+EK E N L K ++ +EKN +LE L ++C L E
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN------SKLECLLNECTSLCE---- 1065
Query: 771 NENENKKLKLKYQCLKDQLEEREKHISIEEEH---LRRMEEARLQLKDQLLCLETEQESI 827
+N+ +LK K+ E K EE + + +E + L+ ++ + +S
Sbjct: 1066 -NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL------ 881
G + +EI E+ K+ D+ + + + KTK + C+ L
Sbjct: 1125 AGGLKQEIMTL-------KEEQNKMQKEVNDLLQENEQLMKVMKTKHE--CQNLESEPIR 1175
Query: 882 ---KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLL 938
KERE+ + + + ++ ++L L + +E L E +EK L
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
Query: 939 EETQ--RKDEEMGSLQD 953
E Q R D E +LQD
Sbjct: 1236 HELQTIRGDLETSNLQD 1252
Score = 109 bits (272), Expect = 2e-23
Identities = 192/929 (20%), Positives = 389/929 (41%), Gaps = 100/929 (10%)
Query: 146 RTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTE 205
RT ++ Q + T L + L + S Q + + L ++ + + K EEL+
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKE--KEKEFQEELSR 402
Query: 206 KLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE 265
+ Q + +++ RL + ++ + +++ D+L + QL+ L++ + K
Sbjct: 403 QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCR 462
Query: 266 HEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKG 325
E A + ++ ++N+L + +E ++ N + E +V L +L
Sbjct: 463 AEQA----FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL--------- 509
Query: 326 LQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVK 385
+ Q Q N+ +E + + R+ Q+ Q + ++LE+ +
Sbjct: 510 --KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 386 RCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQIS 445
C + K++ H +E L +L EK+ +L L+ + ++ + E+ S
Sbjct: 568 DCSQDLLKKREH---HIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKS 624
Query: 446 ELTRHAEDATKQAERYLSELQQSE-ALKEEAEKRRE-DLKLKAQESIRQ-WKLKHKKLER 502
E + + E S++ E LK + K E + +++ E R+ ++ + L
Sbjct: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
Query: 503 ALEKQSETVD-------------ELTGKNNQILKEKDELKT-QLYAALQQIENLRKELND 548
L+ +S V+ E + + +Q E LKT QL ++ +E+ + L++
Sbjct: 685 VLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 549 VLTKRALQEEELHSKEEKLRD-IKSHQADLELEVKN-----SLDTIHRLESELKKQSKIQ 602
+ + ++LH++ E LRD +KS A L + + D + Q
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804
Query: 603 SQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL 662
M E++ E + K+ A + ++ ++ S++ + +DL + E + K +
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
Query: 663 KDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---------KTKHEQ 713
++L +S ET+ I++L+ + HQ + + S+L++ K + EQ
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 714 -NIQELMK--HFKKEK-SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELT 769
IQEL K H ++ E + TL E E ++ +++ ++E+L + L E
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 770 QNENENKKLKLKYQCLKDQLEEREKHIS-IEEEH-------LRRMEEARLQLKD--QLLC 819
E L K + + ++EREK IS + +++ L+R EE +D Q
Sbjct: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044
Query: 820 LETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCE 879
E+ S L + E + C+ K+ +E+LK + H+ E TKL +
Sbjct: 1045 AAQEKNSKLECLLNECTSLCEN-RKNELEQLK------EAFAKEHQ---EFLTKLAF--- 1091
Query: 880 ELKERENREKNLRHQLMLCRQQLRN-LTENK---ESELQCLFQQIERQEQLLDEIHREKR 935
E R +NL +L +Q LR+ +T+N+ +SE L Q+I ++ +++ +E
Sbjct: 1092 ----AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
Query: 936 DLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERT 995
DLL+E ++ + M T+ +LES P + S+ E + R+ C+ +
Sbjct: 1148 DLLQENEQLMKVM------------KTKHECQNLESEPIRNSVKERESE-RNQCNFKPQM 1194
Query: 996 DGRYSKYRVRRNSLQHHQDDTKYRTKSFK 1024
D + + + Q Q + R K K
Sbjct: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELK 1223
Score = 108 bits (271), Expect = 2e-23
Identities = 194/853 (22%), Positives = 363/853 (42%), Gaps = 140/853 (16%)
Query: 201 EELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVER---RQDQLGLMSLQLQEALK 257
+E+ ++N+ Q+ ++ ++ + L E E+ + R+ + R + DQ L++ LK
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 258 K-------QEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVE 310
K Q A+ +++ K+++ E E + ELSR+ + S +TL +
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE-----ELSRQ-----QRSFQTLDQECI 415
Query: 311 ELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRV 370
+++ +LT+ K + H V Q + +Q E+ +E KQ L R
Sbjct: 416 QMKARLTQELQQAKNM-HNVLQAELDKLTSVKQQLEN-----NLEEFKQKL------CRA 463
Query: 371 QLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHF 430
+ F A + E++R ME KE L S E RE+ + E + + L + QN
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 431 DTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE---DLKLKAQ 487
+ +A+ + + +L ++ Q E L+ L++ + + EK+R+ DL K +
Sbjct: 524 EEMKAKNTSQETMLRDL----QEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKRE 578
Query: 488 ESIRQWKLKHKKLER-------ALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 540
I Q K K E+ ALE + + +EL + K E + L + E
Sbjct: 579 HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 541 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTI--HRLESELKKQ 598
NL+ ++N + T Q+ + H E++R ++ + +L +E++N + + +E E +K
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Query: 599 SKIQSQMKVE----KAHLEEEIAELKKSQAQDKAKLLE-----MQESIKDLSAIRADL-- 647
+ ++ Q K E K E E LK SQ + + LE + I D DL
Sbjct: 699 AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
Query: 648 -ANKLAEEERAKKAVLKDLSDLTAQAKSRDEET------ATII----------TQLKLER 690
L + ++K A L D + D++ A II ++ +LE
Sbjct: 759 EYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
Query: 691 D-------VHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEE 743
D + Q + L SL+S K + ++Q+ + + K E E ++ +KAE + +
Sbjct: 819 DQSPKNSAILQNRVDSLEFSLESQK-QMNSDLQKQCEELVQIKGEIEENL--MKAEQMHQ 875
Query: 744 KNMAKIHRGQLEKLKSQCDR----LTEELTQNENENKKLKLKYQCLKDQLEEREKHIS-- 797
+A+ + ++ KL+ + E L+ EN+ K+L+L L D++E + I
Sbjct: 876 SFVAETSQ-RISKLQEDTSAHQNVVAETLSALENKEKELQL----LNDKVETEQAEIQEL 930
Query: 798 IEEEHLRRMEEARLQLKDQLLCLETEQESILGVIG--------------KEIDAACKTFS 843
+ HL LQL + L LE ++ S + + KEI+A+
Sbjct: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990
Query: 844 KDSVEKLKVFSSGPDIHYDPHRWLA----ESKTKLQWLCEEL---------KERENREKN 890
+ ++K + F++ D L+ + K L CEE K + +EKN
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 891 LRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGS 950
+ + +L + +L EN+++EL EQL + +E ++ L + +E
Sbjct: 1051 SKLECLL--NECTSLCENRKNEL----------EQLKEAFAKEHQEFLTKLAFAEERN-- 1096
Query: 951 LQDRVIALETSTQ 963
Q+ ++ LET Q
Sbjct: 1097 -QNLMLELETVQQ 1108
Score = 98.6 bits (244), Expect = 3e-20
Identities = 185/907 (20%), Positives = 387/907 (42%), Gaps = 153/907 (16%)
Query: 161 LHGFHQSLRDLSSEQIRLG---DDFNRELSR--RSRSDAETKRALEE--LTEKLNEAQKQ 213
+H +++ S+E +RL +D +R++ + ++K L+E L K+ +
Sbjct: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIEL 1828
Query: 214 EVVSDRVERRLQELEREMR----TERELVERRQDQLGLMS-LQLQEALKKQEAKAD---- 264
E + +++ +L ++ +EL++R + GL S L++ +E D
Sbjct: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAK 1888
Query: 265 ------EHEGAIKNKLRQTETEKNQLEQE----------LELSRRLLNQSEGSRETLLHQ 308
E ++N+L + +EK +E E ++ + L + +++ ++
Sbjct: 1889 VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVC 1948
Query: 309 VEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDL 368
+EE +L+ +R L+ ++ +SK+ + D+ E ++ + Q+LE S+
Sbjct: 1949 LEE---ELSVVTSERNQLRGELDTMSKKTTAL-DQLSEK------MKEKTQELESHQSEC 1998
Query: 369 R-----VQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRL 423
+ L+ + + K+K HL ++++L + + Q L +
Sbjct: 1999 LHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK-----DSQALSL---- 2049
Query: 424 KEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE--- 480
CE E QI++L + E K++E + L +S+ K K E
Sbjct: 2050 -------TKCELEN-----QIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAAL 2097
Query: 481 ------DLKLKA-QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLY 533
L+L + QE + Q + +KL +E + + K + +E D LK
Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLK---- 2153
Query: 534 AALQQIENLRKELN-----------DVLTKRALQEEELHSKEEKLRDIKSHQAD---LEL 579
++ENL +EL D +A E EE R +K + D L
Sbjct: 2154 ---DKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 580 EVKNSLDTIHRLESELKKQSKIQSQMK---VEKAHLEEEIAELKKSQAQD-KAKLLEMQE 635
E +N I + +L + K+ S K EK E +I E K+ + + +L E+ E
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 636 SIKDL-------SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKL 688
++ L A L + EE + + ++ K L A+ ++ +++ ++ QLK
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK----LRARLEADEKKQLCVLQQLKE 2326
Query: 689 ER---DVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKN 745
D+ + +++L L+ +T E H E ++ + TLKA+ +
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQE--------HAALEAENSKGEVETLKAKI---EG 2375
Query: 746 MAKIHRG---QLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKH-ISIEEE 801
M + RG + ++S+ + LT EL + + +L++ ++ L+E+E+ + ++E+
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 802 HLRRMEEARLQLK---DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPD 858
ME + QLK +++ L +QE+ KE + + + + +EK ++ G D
Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACK---AKEQNLSSQVECLE-LEKAQLL-QGLD 2490
Query: 859 IHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQ 918
+ + L S + L +E+++ + + + ++ + Q+++ + +L
Sbjct: 2491 EAKNNYIVLQSS---VNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-----QEQLVSKLS 2542
Query: 919 QIERQEQLLDEIHREKRDLLEETQRK----DEEMGSLQDRVIALETSTQVALDHLE-SVP 973
Q+E + QL E + E R+L E ++K + SLQD + L++S + + LE +
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Query: 974 EKLSLLE 980
+K+S +E
Sbjct: 2603 DKMSFVE 2609
Score = 95.1 bits (235), Expect = 3e-19
Identities = 160/782 (20%), Positives = 319/782 (40%), Gaps = 112/782 (14%)
Query: 290 LSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQV----SQISKQQSNYQDEQG 345
+S L EG L +++EL QL K + +++ Q Q+ + + KQ+ ++E+
Sbjct: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
Query: 346 EDWRFRR----------GVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEK 395
E +R +E+ KQ + ++ Q+NF +L K+ +E+ ++E
Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNF--QEGQLNSGKKQIEKLEQEL 118
Query: 396 AHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDAT 455
S++E + ++ + + C +K ++ ++
Sbjct: 119 KRCKSELERSQQAAQSADVS--------------LNPCNTPQKIFTTPLTPSQYYSGSKY 164
Query: 456 KQ-AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLER------ALEKQS 508
+ E+Y E+++ + L EAE + K KA +++ Q + H+ + R Q
Sbjct: 165 EDLKEKYNKEVEERKRL--EAEVKALQAK-KASQTLPQATMNHRDIARHQASSSVFSWQQ 221
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE--ELHSKEEK 566
E N+Q + + ++ Q++ R L + KR + S
Sbjct: 222 EKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQ--IGKRDANSSFFDNSSSPHL 279
Query: 567 LRDIKSHQADLELEVKNSLDTIHRLESELKKQ-SKIQS-QMKVEKAHLE----------- 613
L +K+ +L ++ + E E+K Q +K Q Q+++EKA +E
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 614 -EEIAELKKSQAQDKAKLLEMQESIKDLS-----------AIRADLANKLAEEERAKKAV 661
+E+ Q K +++ +K L+ + R L K+ E+E K
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE---KEF 396
Query: 662 LKDLSDLTAQAKSRDEE----TATIITQLKLERDVH---QRELKDLTSSLQSVKTKHEQN 714
++LS ++ D+E A + +L+ +++H Q EL LTS Q ++ E+
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Query: 715 IQELMKHFKKEKSE--AENHIRTLKAESLEEKNMAKIHRGQLEK----LKSQCDRLTEEL 768
Q+L + + ++ EN +R E +E N+ K H Q + L+++ + + L
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Query: 769 TQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
Q++N +++K K + L + ++ I+ +E L +E+ +L + D LE +++
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVAD----LEKQRDCSQ 571
Query: 829 GVIGK---EIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQ-WLCEELK-- 882
++ K I+ SK E K S ++ + L E KT W E K
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKES-KALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 883 -----ERENREKNLRH-QLMLCRQQLRNLTENK-----ESELQCLFQQIERQEQLLD--- 928
E+EN + + H + L QQ+++ N+ E + + L +I +LD
Sbjct: 631 TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
Query: 929 -EIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRD 987
E+ +K +E Q+ + Q + + T +E + KL LL + +D
Sbjct: 691 VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750
Query: 988 SC 989
C
Sbjct: 751 RC 752
Score = 94.0 bits (232), Expect = 7e-19
Identities = 176/884 (19%), Positives = 359/884 (40%), Gaps = 121/884 (13%)
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
+E + R +++QELE ++ ++ ++RQ QL L+ AL+KQ K
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLD----SLEAALQKQ-----------KQ 53
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQ 332
K+ +TE L++E + + E +++ + H+++ +Q+ EG + Q+ +
Sbjct: 54 KVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK 113
Query: 333 ISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA--MASELEEVKRCMER 390
+ ++ + E + + + L S S+ E++K +
Sbjct: 114 LEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK 173
Query: 391 KDKEKAHLASQVENLTRELENGEKQQLQMLDR---------------LKEIQNHFDT--- 432
+ +E+ L ++V+ L + + Q M R ++ +H +
Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233
Query: 433 ----------------CEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAE 476
E + LQI + ++ + +L L Q +A +E
Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL--LDQLKAQNQELR 291
Query: 477 KRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL-------- 528
+ +L+L+ Q ++ K + K + + + EL K + K +DEL
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 529 -KTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRD-IKSHQADLELEVKNSLD 586
+ Y AL+Q L+K D+ +R E S E+K+++ K Q +L + + S
Sbjct: 352 QASTKYTALEQ--KLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQ-QRSFQ 408
Query: 587 TIH--------RLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIK 638
T+ RL EL++ + + ++ E L +L+ + + K KL +++ +
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 639 DLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELK 698
S I+ + + EE + + +L KS E+ A + L+ E ++ L
Sbjct: 469 -ASQIKENELRRSMEEMKKENNLL----------KSHSEQKAREVCHLEAELKNIKQCLN 517
Query: 699 DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAK---IHRGQLE 755
+ + +K K+ QE M +EK + + TL+ L ++ K + L+
Sbjct: 518 QSQNFAEEMKAKNTS--QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLK 575
Query: 756 KLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEE--REKHI-----SIEEEHLRRMEE 808
K + ++L ++L++ E E+K L + K + EE EK + S E+ L +ME
Sbjct: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635
Query: 809 ARLQLKDQL----LCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPH 864
+ L+ ++ CL+T+Q + E + +T D E L V D
Sbjct: 636 EKENLQSKINHLETCLKTQQ-----IKSHEYNERVRTLEMDR-ENLSVEIRNLHNVLDSK 689
Query: 865 RWLAESKTKLQWLCEELKERENREKNLRHQLMLC--RQQLRNLTENKESELQCLFQQIER 922
E++ KL ++ + K + +K+ + +C QL E+ E +LQ L +I
Sbjct: 690 SVEVETQ-KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Query: 923 QEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDF 982
+++ ++H E L + + KD + + +D +L +A D ++ + +
Sbjct: 749 KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL-----LAFDQQPAMHHSFANIIG- 802
Query: 983 KDFRDSCSSSERTDGRYSKYRVRRNS--LQHHQDDTKYRTKSFK 1024
SER++ R + +NS LQ+ D ++ +S K
Sbjct: 803 ---EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQK 843
Score = 66.6 bits (161), Expect = 1e-10
Identities = 167/853 (19%), Positives = 346/853 (40%), Gaps = 102/853 (11%)
Query: 158 MTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVS 217
M +L+ + L +E+ L + N RS T++ EE+ + LNE + +++
Sbjct: 1297 MNKLNELEKICEILQAEKYELVTELN---DSRSECITATRKMAEEVGKLLNEVK---ILN 1350
Query: 218 DRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEA-----LKKQEAKADEHEGAIKN 272
D EL ++ E E+ +Q + L E+ L + + H ++
Sbjct: 1351 DDSGLLHGELVEDI-PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQE 1409
Query: 273 KLRQTETEKNQL-EQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD--------- 322
K ++E L +Q ++S ++ ++ + ++L + L T L +GD
Sbjct: 1410 KFLSLQSEHKILHDQHCQMSSKM-SELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
Query: 323 RKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQ-----DLEKQMSDLRVQLNFSAM 377
+GL +S S+ G+ +R +E+ +LE +S + ++
Sbjct: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVD-EVF 1527
Query: 378 ASELEEVKRCMERKDKEKAHLASQVENLTRELENG-----EKQQLQMLDRLKEIQNHFDT 432
S L+E + A ++E+L EK + Q + + KEIQ
Sbjct: 1528 CSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587
Query: 433 CEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQ 492
+ER+ D L + +Q ++ L+ + K AEK++ + +L + + +
Sbjct: 1588 LSSERQELDC----LRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTE-QLSLELEVAR 1642
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQ--ILKEKDELKTQLYAALQQIENLRKELNDVL 550
+L+ L +T D + G+N I KE T+ + +++ +
Sbjct: 1643 LQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE--------RTPKHDVHQIC 1694
Query: 551 TKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKA 610
K A +++L+ EK+ + + + E + S DT + E K Q + + +
Sbjct: 1695 DKDA--QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSEC---ISEL 1749
Query: 611 HLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTA 670
A + ++ + +Q +K+ S L + + + +R +++L ++ +L +
Sbjct: 1750 SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS 1809
Query: 671 QAKSRDEETATIITQ-LKLERDVHQ--RELKDLTSSLQSVKTKHEQNIQELMKHFKKEKS 727
+ ++ + T I ++LE+ V + +E DL+ L+ H++ +Q + + + S
Sbjct: 1810 KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV-ETSEGLNS 1868
Query: 728 EAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKD 787
+ E H E + + N+AK++ D E ENE ++
Sbjct: 1869 DLEMHADKSSREDIGD-NVAKVN-----------DSWKERFLDVENELSRI--------- 1907
Query: 788 QLEEREKHISIEEEHLRRMEEARLQL-KDQLLCLETEQESILGVIGKEIDAACKTFSKDS 846
R + SIE E L EA L++ + + LCLE + E+ VI C
Sbjct: 1908 ----RSEKASIEHEALYL--EADLEVVQTEKLCLEKDNENKQKVI------VCLE----- 1950
Query: 847 VEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLT 906
E+L V +S + +++ T L L E++KE+ ++ + + + C Q
Sbjct: 1951 -EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 907 ENKESELQCLFQQIERQEQLLDEIHREKR--DLLEETQRKDEEMGSLQDRVIALETSTQV 964
+ K LQ L + E L D+ H +++ L +++Q L++++ L ++
Sbjct: 2010 KEKTELLQTLSSDV--SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
Query: 965 ALDHLESVPEKLS 977
+ ES+ +LS
Sbjct: 2068 LVKESESLQARLS 2080
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 142 bits (359), Expect = 1e-33
Identities = 198/905 (21%), Positives = 393/905 (43%), Gaps = 106/905 (11%)
Query: 150 RFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE 209
R +E + ++L + L D E + DD L + + T+ ++ LTE++
Sbjct: 937 RVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEF 996
Query: 210 AQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA 269
+ +R + +QE ++ + + E + L +L+L E + DE EGA
Sbjct: 997 LNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKL-------EQQVDELEGA 1049
Query: 270 IKNKLR---QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELR------TQLTKAE 320
++ + + E E ++LE L+L+R + E S+ H EELR +Q+
Sbjct: 1050 LEQERKARMNCERELHKLEGNLKLNRESMENLESSQR---HLAEELRKKELELSQMNSKV 1106
Query: 321 GDRKG----LQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA 376
+ KG LQ V ++ Q + +++ + R +ERE+ DL + ++DL +L
Sbjct: 1107 ENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLE-EV 1165
Query: 377 MASELEEVKRCMERKDK-EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCE- 434
S L +++ +++ K +K H + L E + ++ + D L E++ + +
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKK-RHADSLAELEGQVENLQQ 1224
Query: 435 ----AERKHADLQ---------ISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRED 481
E+ +DLQ + ++TR +A K Y L ++ A ++ + D
Sbjct: 1225 VKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLAND 1284
Query: 482 LKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQ--- 538
L A + + W + L R LE++ +++L+ + + ++ ++L+ QL +
Sbjct: 1285 L---AAQKTKLWSESGEFLRR-LEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSA 1340
Query: 539 -IENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADL-ELEVKNSLDTIHRLE--SE 594
L+K D R EEE K E R + A++ + +K + I R E +
Sbjct: 1341 LAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLED 1400
Query: 595 LKKQSKIQSQMKVEK---AHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKL 651
KK+ I+ Q E A+ E + Q Q LE+ +++ DL +R+ A
Sbjct: 1401 AKKELAIRLQEAAEAMGVANARNASLERARHQLQ-----LELGDALSDLGKVRSAAARLD 1455
Query: 652 AEEERAKKAV------------LKDLSDLTAQAKSRD--------EETATIITQLKLERD 691
++ ++ KA+ L D S QA S + EE+ L+ E
Sbjct: 1456 QKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENK 1515
Query: 692 VHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHR 751
Q E+ +LT+ ++ TK+ ++++ K ++EK+E + + + E E+N +KI
Sbjct: 1516 NLQEEISNLTNQVRE-GTKNLTEMEKVKKLIEEEKTEVQ--VTLEETEGALERNESKILH 1572
Query: 752 GQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARL 811
QLE L+++ + L +L++ + E + + K QC D L+ S++ E R+E RL
Sbjct: 1573 FQLELLEAKAE-LERKLSEKDEEIENFRRKQQCTIDSLQS-----SLDSEAKSRIEVTRL 1626
Query: 812 QLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESK 871
+ K + E E + L +++ A K+ + ++ +K D L +S
Sbjct: 1627 KKKMEEDLNEMELQ--LSCANRQVSEATKSLGQLQIQ-IK----------DLQMQLDDST 1673
Query: 872 TKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIH 931
L E++ E R L+ +L + LR+L E E + +++ + ++ +
Sbjct: 1674 QLNSDLKEQVAVAERRNSLLQSEL----EDLRSLQEQTERGRRLSEEELLEATERINLFY 1729
Query: 932 REKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVP-EKLSLLEDFKDFRDSCS 990
+ LL + ++ + ++ +Q + Q A + + E +L E+ K +D+ +
Sbjct: 1730 TQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIA 1789
Query: 991 SSERT 995
ERT
Sbjct: 1790 HLERT 1794
Score = 103 bits (257), Expect = 9e-22
Identities = 173/820 (21%), Positives = 339/820 (41%), Gaps = 133/820 (16%)
Query: 325 GLQHQVSQISK--QQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELE 382
GL+ + +Q+ K ++S +Q E+ ++ ++ L ++ +DL +QL A L
Sbjct: 863 GLKEECAQLQKALEKSEFQREE---------LKAKQVSLTQEKNDLILQLQ--AEQETLA 911
Query: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
V+ E K K L ++V+ L+ +E E+ ++ R ++++ D C +K D
Sbjct: 912 NVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLE---DECFELKKEIDD 968
Query: 443 QISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQ------ESIRQWKLK 496
+ L + ++ + + ++ E L E+ K K+ + + + + K
Sbjct: 969 LETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEK 1028
Query: 497 HKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYA----------ALQQIENLRKEL 546
L +A K + VDEL G Q K + + +L+ +++ +E+ ++ L
Sbjct: 1029 LSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHL 1088
Query: 547 NDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMK 606
+ L K+ L+ +++SK E + + A L+ VK I L+ +L+ + +++M+
Sbjct: 1089 AEELRKKELELSQMNSKVENEKGLV---AQLQKTVKELQTQIKDLKEKLEAERTTRAKME 1145
Query: 607 VEKAHLEEEIAEL------------------KKSQAQDKAKLLEMQESIKDLSAIRADL- 647
E+A L +++A+L KK + + + +M+E+ A L
Sbjct: 1146 RERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLK 1205
Query: 648 ---ANKLAEEE-------RAKKAVLKDLSDL-------------TAQAKSRDEETATIIT 684
A+ LAE E + K+ + KD SDL +AK+ E+ T+
Sbjct: 1206 KRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYE 1265
Query: 685 QLKLERDVHQRELKDLTSSLQSVKTK----------HEQNIQELMKHFKKEKSEAENHIR 734
+ E ++ L + L + KTK + + L+ +EKS I
Sbjct: 1266 ERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIE 1325
Query: 735 TLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKL--------------KL 780
L+ + +E L+K + CD L E+ + + +L ++
Sbjct: 1326 DLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRM 1385
Query: 781 KYQ----CLKDQLEEREKHISIE-EEHLRRMEEARLQ---LKDQLLCLETEQESILGVIG 832
KY+ + LE+ +K ++I +E M A + L+ L+ E L +G
Sbjct: 1386 KYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLG 1445
Query: 833 KEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLR 892
K AA + K ++ K + H + L S+ ++Q L EL + KN
Sbjct: 1446 KVRSAAARLDQK-QLQSGKALADWKQKHEESQALLDASQKEVQALSTELL----KLKNTY 1500
Query: 893 HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQ 952
+ ++ ++ LR +N + E+ L Q+ + L E+ + K+ L+EE K E +L+
Sbjct: 1501 EESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKK-LIEE--EKTEVQVTLE 1557
Query: 953 DRVIALETSTQVALD-HLESVPEKLSLL-------EDFKDFR-------DSCSSSERTDG 997
+ ALE + L LE + K L E+ ++FR DS SS ++
Sbjct: 1558 ETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEA 1617
Query: 998 RYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTRG 1037
+ S+ V R + +D + + +R E + + G
Sbjct: 1618 K-SRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLG 1656
Score = 102 bits (254), Expect = 2e-21
Identities = 148/733 (20%), Positives = 301/733 (41%), Gaps = 127/733 (17%)
Query: 197 KRALEELTEKLNEAQKQEVVSDRVERRLQELERE---MRTERELVERRQDQLGLMSLQLQ 253
KR + L E + + + V ++E+ +L+ E + T E + R + + +
Sbjct: 1206 KRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYE 1265
Query: 254 EALKKQEAKADEHEGAIKNKLRQTET----EKNQLEQELELSRRLLNQSEGSRETLLHQV 309
E L + AK D+ + N L +T E + + LE L+NQ + Q+
Sbjct: 1266 ERLHEATAKLDKVT-QLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQI 1324
Query: 310 EELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLR 369
E+LR QL K + L H + + + +++ E+ + + R + +M R
Sbjct: 1325 EDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWR 1384
Query: 370 VQL--NFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ-QLQMLDRLKEI 426
++ N +LE+ K+ + + +E A LE Q QL++ D L ++
Sbjct: 1385 MKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL 1444
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS-EALKEEAEKRREDLK-- 483
+ A LQ + + ++++ L Q+ +AL E K + +
Sbjct: 1445 -GKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEES 1503
Query: 484 LKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEK---DELKTQLYAALQQIE 540
+ QE++R+ ++K L+ + + V E T ++ K K +E KT++ L++ E
Sbjct: 1504 IVGQETLRR---ENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETE 1560
Query: 541 -----NLRKELN---DVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLE 592
N K L+ ++L +A E +L K+E++ + + Q +++SLD+ +
Sbjct: 1561 GALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSR 1620
Query: 593 SEL----KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLA 648
E+ KK + ++M+++ + +++E KS Q + ++ ++Q + D + + +DL
Sbjct: 1621 IEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK 1680
Query: 649 NKLAEEERAKKAVLKDLSDL------TAQAKSRDEE----------------TATIITQL 686
++A ER + +L DL T + + EE T+ + +
Sbjct: 1681 EQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKK 1740
Query: 687 KLERDVH--QRELKDLTSSLQSVKTKHEQ------NIQELMK-------HFKKEKSEAEN 731
KLE DV Q+E +++ Q+ + K ++ N+ E +K H ++ + E
Sbjct: 1741 KLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQ 1800
Query: 732 HIRTLKAESLEEKNMAKI-HRGQLEKLKSQC------------------------DRLTE 766
I L+ E + MA + R Q++KL+S+ +R +
Sbjct: 1801 TITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK 1860
Query: 767 ELTQNENENKK-------------LKL-------------------KYQCLKDQLEEREK 794
ELT E+KK LK+ KY+ + +L E ++
Sbjct: 1861 ELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE 1920
Query: 795 HISIEEEHLRRME 807
+ E + +++
Sbjct: 1921 RAEVAESQVNKLK 1933
Score = 101 bits (251), Expect = 4e-21
Identities = 129/617 (20%), Positives = 276/617 (44%), Gaps = 64/617 (10%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALE----ELTEKLNEAQKQEVVSDRVERR 223
LR+ E+ + + +R LS+ + + + E + TE L +A+K+ + R
Sbjct: 1355 LREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAI------R 1408
Query: 224 LQELEREM---RTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETE 280
LQE M +ER + QL L+L +AL K + K Q+
Sbjct: 1409 LQEAAEAMGVANARNASLERARHQL---QLELGDALSDL-GKVRSAAARLDQKQLQSGKA 1464
Query: 281 KNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNY 340
+Q+ E S+ LL+ S+ + L ++ +L+ ++ ++ L+ + + ++ SN
Sbjct: 1465 LADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNL 1524
Query: 341 QDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKD--KEKAHL 398
++ E + +E+ K+ +E++ ++++V L + A E E K + + + KA L
Sbjct: 1525 TNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAEL 1584
Query: 399 ASQVENLTRELENGEKQQLQMLDRLK-----EIQNHFDTCEAERK------HADLQISEL 447
++ E+EN ++Q +D L+ E ++ + ++K +LQ+S
Sbjct: 1585 ERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCA 1644
Query: 448 TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE--RALE 505
R +ATK + +++ + +++ + DLK + + R+ L +LE R+L+
Sbjct: 1645 NRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQ 1704
Query: 506 KQSETVDELTGKNNQILKEKDELK---TQLYAALQQIENLRKELNDVLTKRALQEEELHS 562
+Q+E L+ ++L+ + + TQ + L Q + L ++ + + +E +
Sbjct: 1705 EQTERGRRLS--EEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQN 1762
Query: 563 KEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKS 622
EEK + A+L E+K DTI LE + + M+ L++ +AE ++
Sbjct: 1763 AEEKAKKAAIEAANLSEELKKKQDTIAHLE-------RTRENMEQTITDLQKRLAEAEQM 1815
Query: 623 QAQDKAKLLEMQES-IKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETAT 681
K ++ ES +++L + AE +R + + + + +LT QA EE
Sbjct: 1816 ALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQA----EEDKK 1871
Query: 682 IITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESL 741
+++++ + D Q ++++ ++ +T+ Q + + +KK++ E
Sbjct: 1872 NLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSK----YKKQQHELN----------- 1916
Query: 742 EEKNMAKIHRGQLEKLK 758
E K A++ Q+ KLK
Sbjct: 1917 EVKERAEVAESQVNKLK 1933
Score = 91.3 bits (225), Expect = 5e-18
Identities = 94/477 (19%), Positives = 212/477 (44%), Gaps = 57/477 (11%)
Query: 157 DMTQLHGFHQSLRD--------LSSEQIRLGDDFNRELSRRSRSDAETKRALEE---LTE 205
D Q H Q+L D LS+E ++L + + + + E K EE LT
Sbjct: 1467 DWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTN 1526
Query: 206 KLNEAQKQEVVSDRVERRLQELEREMRTERE----LVERRQDQLGLMSLQLQEALKKQEA 261
++ E K ++V++ ++E + E++ E +ER + ++ L+L EA + E
Sbjct: 1527 QVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELER 1586
Query: 262 KADEHEGAIKNKLRQT----------------------------ETEKNQLEQELELSRR 293
K E + I+N R+ E + N++E +L + R
Sbjct: 1587 KLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANR 1646
Query: 294 LLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRG 353
++++ S L Q+++L+ QL + L+ QV+ ++ S Q E + +
Sbjct: 1647 QVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQ 1706
Query: 354 VEREKQDLEKQMSDLRVQLNF-----SAMASELEEVKRCMERKDKEKAHLASQVENLTRE 408
ER ++ E+++ + ++N +++ S+ ++++ + R KE + + +N +
Sbjct: 1707 TERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEK 1766
Query: 409 LENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS 468
+ + + + LK+ Q+ E R++ + I++L + +A + A L S
Sbjct: 1767 AKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMA------LMGS 1820
Query: 469 EALKEEAEKRREDLKLKAQESIR---QWKLKHKKLERALEKQSETVDELTGKNNQILKEK 525
++ E R +L+ + + IR + + ++LER +++ + +E +++ +
Sbjct: 1821 RKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQM 1880
Query: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 582
D+L+ ++ QQ+E + N L+K Q+ EL+ +E+ +S L+++ +
Sbjct: 1881 DKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAR 1937
Score = 83.2 bits (204), Expect = 1e-15
Identities = 117/553 (21%), Positives = 221/553 (39%), Gaps = 97/553 (17%)
Query: 488 ESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELN 547
E + K + +L++ALEK +EL K + +EK++L QL A
Sbjct: 859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQA------------- 905
Query: 548 DVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKV 607
++E L + EE+ + + LE VK L ++++ +I S++
Sbjct: 906 --------EQETLANVEEQCEWLIKSKIQLEARVK-------ELSERVEEEEEINSELTA 950
Query: 608 EKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSD 667
LE+E ELKK DL L + E+ K+ + +
Sbjct: 951 RGRKLEDECFELKKE---------------------IDDLETMLVKSEKEKRTTEHKVKN 989
Query: 668 LTAQAKSRDEETATIITQLKLERDVHQRELKDL------TSSLQSVKTKHEQNIQELMKH 721
LT + + +E+ + + K+ ++ HQ+ L DL SSL K EQ + EL
Sbjct: 990 LTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGA 1049
Query: 722 FKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 781
++E+ N R L + + K++R +E L+S L EEL + E E ++ K
Sbjct: 1050 LEQERKARMNCERELH----KLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSK 1105
Query: 782 YQC--------------LKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
+ L+ Q+++ ++ + E +ME R L L L E +
Sbjct: 1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV 1165
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
G +++ K +K +KL +H++ S + + + L E E +
Sbjct: 1166 GGSSLAQLEITKKQETK--FQKLHRDMEEATLHFE-----TTSASLKKRHADSLAELEGQ 1218
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQ-------CLFQQIERQEQLLDEIHREKRDLLEE 940
+NL QQ++ E +S+LQ +Q+ R + +++ + L E
Sbjct: 1219 VENL--------QQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHE 1270
Query: 941 TQRKDEEMGSLQDRVIALETST-QVALDHLESVPEKLSLLEDFKDFRDSCSSS-ERTDGR 998
K +++ L + + A +T + + L + EK +L+ + + + E G+
Sbjct: 1271 ATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQ 1330
Query: 999 YSKYRVRRNSLQH 1011
K +++L H
Sbjct: 1331 LEKETKSQSALAH 1343
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 141 bits (356), Expect = 3e-33
Identities = 226/1006 (22%), Positives = 427/1006 (42%), Gaps = 157/1006 (15%)
Query: 44 ITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRS 103
+ + +Q+ + N V + ++ E ++ IE L +++ L +RL+ S
Sbjct: 156 VAAHIQEVTHNQENVFDL--QWMEVTDMSQEDIEPLLKNMA-----LHLKRLIDERDEHS 208
Query: 104 ISVTSLSASDLDGGTGSELHHFP--PTSPLKDYGDPQGIKRMRSRTGV------------ 149
++ LS + DG LH P +S G P G+KR SR +
Sbjct: 209 ETIIELS-EERDG-----LHFLPHASSSAQSPCGSP-GMKRTESRQHLSVELADAKAKIR 261
Query: 150 RFVQETDDMT-QLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLN 208
R QE ++ T QL Q L + E RL + N L +RS + L+ L EK
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDELDALREKAV 320
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE-HE 267
K E R + RL ++E EL E Q L ++ L++ L+ A++D+ HE
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHE 379
Query: 268 GA-----IKNKLRQTETEKN----QLEQELELSRRLLNQSEGSRETLLH---QVEELRTQ 315
+K KL E E++ ++E+ +E + L + S + LH ++E++
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 316 LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFS 375
+E +K L H+V++++ + +E E Q L K + +LR ++
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRL-------------LKLEMENQSLTKTVEELRTTVD-- 484
Query: 376 AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435
+E + + +KE L+ +VE L E+ EKQ LQ C+
Sbjct: 485 ----SVEGNASKILKMEKENQRLSKKVEILENEIVQ-EKQSLQ-------------NCQN 526
Query: 436 ERKHADLQISELTRHAEDATKQAERYLSELQQ-SEALKEEAEKRREDLKLKAQESIRQWK 494
K + ++L + E + +ER + L+Q +E L + R+ ++ A+ ++ +
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
Query: 495 LKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRA 554
++K L ++++ S + ++ + QI KE + K + ++ E L EL+ + +
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG----ERAEELENELHHLEKENE 642
Query: 555 LQEEELHSKE---EKLRDIKSHQADLELE---VKNSLDTIHRLESELKKQSKIQSQMKVE 608
L ++++ + + EK+ ++ ++LE E +K +LD+ L +L+ K SQ+ E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 609 KAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL 668
L + LK + K+ ++Q K+L + E+E+ KK + +L
Sbjct: 703 NLELRRNVESLKCASM----KMAQLQLENKELES----------EKEQLKKGL-----EL 743
Query: 669 TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQEL-MKHFKKEKS 727
+ + E L +E Q+ L++ +Q + E +Q+L M++ +K+
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL----ESELQDLEMENQTLQKN 799
Query: 728 EAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKD 787
E I + + E LE++N + L+ + +L ++ Q E ENK+L+ + +
Sbjct: 800 LEELKISSKRLEQLEKEN---------KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 788 QLEEREKHI-SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDA-ACKTFSKD 845
LEE I ++E+E+ +E + + + E E+E+ V ID T +D
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 846 SV-EKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRN 904
V EKLK D+ H K + L +E ++R K L +L L+
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL---ESTLKK 967
Query: 905 LTENKESELQCLFQQIERQ----EQLLDEIHREKRDLLEETQRKDEE------------- 947
E KE ++ L ++E +QL E+ K++ QR+DEE
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027
Query: 948 -------------MGSLQDRVIALETSTQVALDHLESVPEKLSLLE 980
+ ++DR+I +E + +++ +L LE
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1073
Score = 125 bits (313), Expect = 3e-28
Identities = 196/1008 (19%), Positives = 415/1008 (41%), Gaps = 135/1008 (13%)
Query: 67 EYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFP 126
E N Q A H E +E+ +D+ + + L+ + ++ + + D G EL
Sbjct: 381 EKENLQLKAKLHDME-MERDMDRKKIEELMEEN--MTLEMAQKQSMDESLHLGWELEQIS 437
Query: 127 PTSPLKDYGDPQ---GIKRMRSRTGVRFVQETDDMTQ-----------LHGFHQSLRDLS 172
TS L + + + S ++ E +T+ + G + +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 173 SEQIRLG---DDFNRELSRRSRSDAETKRALEELTEKLNEAQKQ-EVVSDRVERRLQELE 228
E RL + E+ + +S + ++L ++ + +K E + + ER+++ LE
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 229 REMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQEL 288
+E + V + + + + + ++K+ E +KL + E EK Q+++EL
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 289 ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDW 348
E + +G R EEL +L E + + LQ +++ + +
Sbjct: 618 EHYKE-----KGER------AEELENELHHLEKENELLQKKITNLKITCEKIE------- 659
Query: 349 RFRRGVEREKQDLEKQMSDLRVQLN-FSAMASELEEVKRCMERKDKEKAHLASQVENL-- 405
+E+E +LE++ L+ L+ F + +LE +++ + D+E L VE+L
Sbjct: 660 ----ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 406 -----------TRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDA 454
+ELE+ ++Q + L+ LK + E + D++ L + E++
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 455 TKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDEL 514
K+ ++ SELQ E + +K E+LK+ ++ + Q + ++K LE+ + + +L
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKENKSLEQETSQLEKDKKQL 834
Query: 515 TGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQ 574
+N ++ ++ + T L +I NL KE + + + +E +L++++
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC----VRLKELEKEN 890
Query: 575 ADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQ 634
+L + T+ L +L + QM + L E+ ++ +K +LL +
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI----GLNKERLLHDE 946
Query: 635 ESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQ 694
+S ++ R K K S L + ++E+ A + +L+ + +Q
Sbjct: 947 QS---------------TDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
Query: 695 RELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQL 754
+ L L++VK +E K++ + E +++ S E+ + +
Sbjct: 992 Q----LRQELKTVKKNYEA---------LKQRQDEERMVQSSPPISGEDNKWERESQETT 1038
Query: 755 EKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLK 814
+L DRL E E N L+ + Q LK QL++ E + + + ++ + L+
Sbjct: 1039 RELLKVKDRLIEV----ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 815 DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKL 874
+Q L+T Q + L V +++ + + + L SS E++ +
Sbjct: 1095 EQNTTLQT-QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS------------LENENE- 1140
Query: 875 QWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
+KERE+ K+L L+ ++L L E + SE + L + + + E
Sbjct: 1141 ----SVIKEREDL-KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
Query: 935 RDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLED------FKDFRDS 988
RDL + + ++ G L+D L+ + V ++ LLE+ +++
Sbjct: 1196 RDLEDRYNQLLKQKGQLED------------LEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 989 CSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTR 1036
C ++R + YS+ LQ + K + K ++T LE ++
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
Score = 117 bits (292), Expect = 8e-26
Identities = 192/866 (22%), Positives = 379/866 (43%), Gaps = 116/866 (13%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA-----QKQEVVSDRV 220
Q+ ++LS + ++ + + + + LE+ E LN+ Q+ ++ +
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA--- 578
Query: 221 ERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA--IKNKLRQTE 278
E R++++E+E + E ++ +L + + ++ K+ E ++ E A ++N+L E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 279 TEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQS 338
E N+L Q+ + ++ + + E ++E +L K K L Q+ + K+ S
Sbjct: 639 KE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697
Query: 339 NYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMER-----KDK 393
+E E RR VE K M ++QL + SE E++K+ +E K
Sbjct: 698 QLDEENLE---LRRNVESLKC---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Query: 394 EKAHLASQ---VEN--LTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
E+ ++ Q +EN L + LEN K+ Q+ L++++ T + + +L+IS +
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE--ELKIS--S 807
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERA-LEKQ 507
+ E K+ + E Q E K++ EK E+ +L+ Q I+ L+ ++ LEK+
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEK--ENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 508 SETVDELTG-------KNNQILKEKDELKTQLYAALQQIENLRKEL-----------NDV 549
++T+ + G + ++ KE EL + ++ + LR++L ND+
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 550 ------LTKRALQEEELHSKEEKLRD--IKSHQADLELEVKNSLDT----IHRLESELKK 597
L K L +E L E+ D K ++ LE +K SL+ I LE+ L++
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985
Query: 598 QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLL---------------EMQESIKDLSA 642
+ Q++ E +++ LK Q QD+ +++ E QE+ ++L
Sbjct: 986 STNYNQQLRQELKTVKKNYEALK--QRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043
Query: 643 IRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQ-LKLERDVHQRELKDLT 701
++ ++L E ER + + L Q K + + + Q L L+R + ++ T
Sbjct: 1044 VK----DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1099
Query: 702 SSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQC 761
Q+ K + E + + + +N ++ SLE +N + I + E LKS
Sbjct: 1100 LQTQNAKLQVENSTL----NSQSTSLMNQNAQLLIQQSSLENENESVIK--EREDLKSLY 1153
Query: 762 DRLTEELTQNENENKKLKLKYQCLKDQ---LEEREKHISIE----EEHLRRMEEARLQLK 814
D L ++ + E +++ +Y+ L + L+ K++ +E E+ ++ + + QL+
Sbjct: 1154 DSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLE 1213
Query: 815 DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDI----------HYDPH 864
D L+ EQE +L + K + + K E ++ + + H +
Sbjct: 1214 DLEKMLKVEQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1272
Query: 865 RWLAESK---TKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIE 921
L SK T+L+ +LKE+ + +L + L L N E E + L QI+
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1332
Query: 922 R---QEQLLDEIHREKRDLLEETQRK 944
Q + L E + E +DL QR+
Sbjct: 1333 TLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Score = 97.1 bits (240), Expect = 8e-20
Identities = 187/894 (20%), Positives = 372/894 (41%), Gaps = 155/894 (17%)
Query: 35 VEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQR 94
V+ + + + +D + Q+++ + RE S Q +E E L Q++ LR +
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 95 LLRNSGG------------RSISVTSLSASDLD---GGTGSELHHFPPTSPLKDYGDPQG 139
+ SI TS S ++ EL H+ +G
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE----------KG 624
Query: 140 IKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA 199
+ + +++ +++ Q + + + E+I + N EL R +R +T +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKI---TCEKIEALEQENSELERENRKLKKTLDS 681
Query: 200 LEELTEKLNEAQKQEVVSDR----VERRLQELE------REMRTERELVERRQDQLGLMS 249
+ LT +L +K+ D + R ++ L+ +++ E + +E ++QL
Sbjct: 682 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 250 LQLQEALKKQEAKADEHEGA-IKN-KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLH 307
L+ + KK E ++G I+N +L++T N+ Q+LE L E +TL
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE---LQDLEMENQTLQK 798
Query: 308 QVEELRT---QLTKAEGDRKGLQHQVSQISK-------------QQSNYQDEQGEDWRFR 351
+EEL+ +L + E + K L+ + SQ+ K QQ+ +D E+ +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 352 RG-VEREKQDLEKQMSDLRVQ-LNFSAMASELEE-VKRCME--------RKDKEKAHLAS 400
G +E+E + L K++ + + + E +E VKR R+D L +
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 401 Q-----VENLTRELENGEKQQLQML--------DRLKEIQNHFD-TCEAERKHADLQISE 446
Q +E LT ELE + ++L R K +++ + T + + + +I+
Sbjct: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESI------RQWKLKHKKL 500
L E++T ++ EL+ + EA K+R+D + Q S +W+ + ++
Sbjct: 979 LEARLEESTNYNQQLRQELKTVKK-NYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1037
Query: 501 ERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEEL 560
R L K + + E+ N + EK LKTQL Q NL+ ++ ALQ + +
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI------LALQRQTV 1091
Query: 561 HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELK 620
S +E+ +++ A +L+V+NS T++ + L Q+ +Q+ ++++ LE E +
Sbjct: 1092 -SLQEQNTTLQTQNA--KLQVENS--TLNSQSTSLMNQN---AQLLIQQSSLENENESVI 1143
Query: 621 KSQAQDKA---KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLK-------DLSDLTA 670
K + K+ L++ E ++ L +A L + K+ K DL D
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 671 QAKSRDEETATIITQLKLERDVHQRELKD------------------------LTSSLQS 706
Q + + + LK+E++ E K+ L +
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263
Query: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTE 766
++T H+ N++ L+ + K E++ E LK E ++ ++ KL +QC+ L++
Sbjct: 1264 LQTDHK-NLKSLLNNSKLEQTRLEAEFSKLK-EQYQQLDITST------KLNNQCELLSQ 1315
Query: 767 ELTQNENENKKLKLKYQ--------CLKDQLEEREKHISIEEEHLRRMEEARLQ 812
E EN+ L + Q L+ +E ++ + +++ ++ E R Q
Sbjct: 1316 LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQ 1369
Score = 92.4 bits (228), Expect = 2e-18
Identities = 145/647 (22%), Positives = 273/647 (42%), Gaps = 75/647 (11%)
Query: 403 ENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
++L+ EL + + + ++ L+E C+ E + ++++ L + + A
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 463 SELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ +AL+E+A R D KL+++ S ++K+ +E V+EL N +L
Sbjct: 307 MYRDELDALREKAV--RVD-KLESEVS------RYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 523 KEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 582
+ K L+ QL E R + ++LH E++ +K+ D+E+E
Sbjct: 358 ETKTMLEDQL-------EGTRA-----------RSDKLHELEKENLQLKAKLHDMEMERD 399
Query: 583 NSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSA 642
I L E Q Q E HL E+ ++ ++ +A + + +L+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT- 458
Query: 643 IRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTS 702
+++L + E +++ K + +L S + + I LK+E++ + K
Sbjct: 459 -----SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSKKVEIL 510
Query: 703 SLQSVKTKHE-QNIQELMKHFKKEKSEAENHIRTLKAES------LEEKNMAKIHRGQLE 755
+ V+ K QN Q L K KEK++ E I TL+ S LE++N H Q
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE---HLNQTV 567
Query: 756 KLKSQCDRLTEELTQNENENKKLKLKYQCLKD------QLEEREKHISIEEEHLRRMEEA 809
Q +++ E + E K+ K+ ++ +K+ ++E ++ I E EH + E
Sbjct: 568 SSLRQRSQISAEARVKDIE-KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 810 RLQLKDQLLCLETEQESI------LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDP 863
+L+++L LE E E + L + ++I+A + S+ E K+ +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 864 HRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESE--------LQC 915
+ + K Q E L+ R N E + + + QL N E E L+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 916 LFQQIERQE---QLLDEIHREKRDLLEETQRKDEEMGS-LQDRVIALETST-QVALDHLE 970
F++ ER E Q LD ++ + LE + +K +++ S LQD + +E T Q L+ L+
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD--LEMENQTLQKNLEELK 804
Query: 971 SVPEKLSLLE-DFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDT 1016
++L LE + K S E+ + K R +D T
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Score = 78.2 bits (191), Expect = 4e-14
Identities = 133/671 (19%), Positives = 281/671 (41%), Gaps = 77/671 (11%)
Query: 418 QMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEA---LKEE 474
+ ++R++ + FDT A H I E+T + E+ ++++ Q + LK
Sbjct: 140 EFIERIQGLD--FDTKAAVAAH----IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNM 193
Query: 475 AE--KRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL 532
A KR D + + E+I + + L S + + + L +L
Sbjct: 194 ALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL 253
Query: 533 YAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNS---LDTIH 589
A +I LR+EL + + ++EL E +L+ ++ +L + +++ D +
Sbjct: 254 ADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD 313
Query: 590 RLESELKKQSKIQSQMKVEKAHLEE------EIAELKKSQAQDKAKLLEMQESIKDL--- 640
L + + K++S++ K L + + ELK +D LLE + ++D
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----EDNQVLLETKTMLEDQLEG 369
Query: 641 SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDL 700
+ R+D ++L +E KA L D+ + + EE L++ + E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 701 TSSLQSVKTKHE--QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLK 758
L+ + E + Q+ + H E + + R LK E +E +++ K +E+L+
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSS----RLLKLE-MENQSLTK----TVEELR 480
Query: 759 SQCDRL---TEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKD 815
+ D + ++ + E EN++L K + L++++ + ++ + + + + + + QL+
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 816 QLLCLETEQESILGVIGKEIDAACKTFSK-DSVEKLKVFSSGPDIHYDP---HRWLAESK 871
+ L E + ++ +E + +T S ++ + DI + H + E+
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 872 TKLQWL----------CEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIE 921
+KL + E KE+ R + L ++L ++ L + K + L+ ++IE
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIE 659
Query: 922 RQEQLLDEIHREKR-----------------DLLEETQRKDEEMGSLQDRVIALETST-- 962
EQ E+ RE R L +E + DEE L+ V +L+ ++
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
Query: 963 --QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRT 1020
Q+ L++ E EK L + + + S +ER + Y + LQ +++ +
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 1021 KSFKGDRTFLE 1031
+ + + LE
Sbjct: 780 QQLESELQDLE 790
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 141 bits (356), Expect = 3e-33
Identities = 219/1045 (20%), Positives = 422/1045 (40%), Gaps = 235/1045 (22%)
Query: 150 RFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEK--- 206
R E + +L + L D SE + DD L++ + T+ ++ LTE+
Sbjct: 927 RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 986
Query: 207 --------------LNEAQKQ-----EVVSDRV----------ERRLQELEREMRTEREL 237
L EA +Q +V D+V E+++ +LE + E+++
Sbjct: 987 LDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKV 1046
Query: 238 ---VERRQDQL---------GLM-----SLQLQEALKKQEAKADEHEGAIKN-------- 272
+ER + +L +M LQL+E LKK+E ++ I++
Sbjct: 1047 RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQL 1106
Query: 273 --KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEG--------- 321
KL++ + +LE+ELE R + E R L ++EE+ +L +A G
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1166
Query: 322 --------------DRKGLQHQ--VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQM 365
+ LQH+ + + K+ ++ E GE ++R KQ LEK+
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ---IDNLQRVKQKLEKEK 1223
Query: 366 SDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKE 425
S+ +++L+ + S +E++ + +K L Q +LE ++ + +
Sbjct: 1224 SEFKLELD--DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281
Query: 426 IQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS----------------- 468
+Q + + + IS+LTR T+Q E +L++
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD 1341
Query: 469 -----EALKEEAEKRREDLKL--KAQESIRQWKLKH---------------KKLERALEK 506
E +EE E + E ++ KA + QW+ K+ KKL + L+
Sbjct: 1342 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1401
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIE--------------NLRKELNDVLTK 552
E V+ + K + + K K L+ ++ + +E N K L + K
Sbjct: 1402 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1461
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELK---------------- 596
+ EL S +++ R + + L+ + SL+ + + E K
Sbjct: 1462 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEG 1521
Query: 597 -----KQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSA-IRADLANK 650
+ K++ Q++VEK L+ + E + S ++ K+L Q + A I LA K
Sbjct: 1522 GKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581
Query: 651 LAEEERAKK---AVLKDL-SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQS 706
E E+AK+ V+ L + L A+ +SR+E + + K+E D+++ E++
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNE---VLRVKKKMEGDLNEMEIQ-------- 1630
Query: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTE 766
+ H + +EA+ +++L +++ K + QL+ D L E
Sbjct: 1631 ------------LSHANRMAAEAQKQVKSL-------QSLLKDTQIQLDDAVRANDDLKE 1671
Query: 767 ELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQL----KDQLLCLET 822
+ E N L+ + + L+ +E+ E+ + E+ L E R+QL L+ +
Sbjct: 1672 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKK 1730
Query: 823 EQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELK 882
+ ES L + E++ A + +++ EK K ++ T + EELK
Sbjct: 1731 KMESDLTQLQSEVEEAVQE-CRNAEEKAK-----------------KAITDAAMMAEELK 1772
Query: 883 ERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQ 942
+ ++ +L Q +++L + Q + ++Q Q L+ RE LE Q
Sbjct: 1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQ 1832
Query: 943 RKDEE----MGSLQDRVIALETSTQ---VALDHLESVPEKLSL-LEDFKDFRDSCSSSER 994
+++ E M + R+ L T+ L L+ + +KL L ++ +K R + + E+
Sbjct: 1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYK--RQAEEAEEQ 1890
Query: 995 TDGRYSKYRVRRNSLQHHQDDTKYR 1019
+ SK+R +QH D+ + R
Sbjct: 1891 ANTNLSKFR----KVQHELDEAEER 1911
Score = 117 bits (292), Expect = 8e-26
Identities = 175/843 (20%), Positives = 333/843 (39%), Gaps = 149/843 (17%)
Query: 76 IEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYG 135
IE L+E LE LR+ R + S + G T ++ K
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE-----MNKKREA 1171
Query: 136 DPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAE 195
+ Q ++R ++ + + H S+ +L EQI D+ R + + +E
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHA--DSVAELG-EQI---DNLQRVKQKLEKEKSE 1225
Query: 196 TKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEA 255
K L+++T + + K + ++V R L++ E R + E +R + +LQ
Sbjct: 1226 FKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285
Query: 256 LKKQEAKADEHEGAIKNKLR-------QTETEKNQLEQELELSRRLLNQSEGSRETLLHQ 308
+ + +E E I R Q E K QLE+E + L + + +R H
Sbjct: 1286 NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR----HD 1341
Query: 309 VEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRR---------------- 352
+ LR Q + + LQ +S+ + + + ++ + D R
Sbjct: 1342 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1401
Query: 353 -------------GVEREKQDLEKQMSDLRVQLNFS-AMASELEEVKRCMERKDKEKAHL 398
+E+ K L+ ++ DL V + S A A+ L++ +R DK A
Sbjct: 1402 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF---DKILAEW 1458
Query: 399 ASQVENLTRELENGEKQQLQMLDRLKEIQN-------HFDTCEAERKHADLQISELTRHA 451
+ E ELE+ +K+ + L +++N H +T + E K+ +IS+LT
Sbjct: 1459 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 452 ----------EDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE 501
E KQ E ELQ + E + + E L+AQ Q K + +E
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAE---IE 1575
Query: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH 561
R L ++ E +++ + +++ D L+T L A + N+VL + E +L+
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVV---DSLQTSLDAET-------RSRNEVLRVKKKMEGDLN 1625
Query: 562 SKEEKLRDIKSHQADLELEVKN----------SLDTIHRLESELKKQSKIQSQ----MKV 607
E +L A+ + +VK+ LD R +LK+ I + ++
Sbjct: 1626 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1685
Query: 608 EKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSD 667
E L + + ++S+ + +L+E E ++ L + L N+ + E + ++ +
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745
Query: 668 LTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQEL--------- 718
+ ++ +E+ IT + + ++E +D ++ L+ +K EQ I++L
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1804
Query: 719 --MKHFKKEKSEAENHIRTLKAE-SLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENEN 775
+K KK+ + E +R L+ E E+K A+ +G + +R +ELT E+
Sbjct: 1805 IALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKS-----ERRIKELTYQTEED 1859
Query: 776 KKLKLKYQCLKD--------------------------------QLEEREKHISIEEEHL 803
KK L+ Q L D +L+E E+ I E +
Sbjct: 1860 KKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1919
Query: 804 RRM 806
++
Sbjct: 1920 NKL 1922
Score = 113 bits (283), Expect = 9e-25
Identities = 169/805 (20%), Positives = 348/805 (43%), Gaps = 86/805 (10%)
Query: 213 QEVVSDRVERRLQELERE-----MRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHE 267
+E+ +R+ R + ++ + MR E + + R+D L ++ ++ + + +
Sbjct: 776 EEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLY 835
Query: 268 GAIKNKLRQTETEKNQLEQELELSR--RLLNQSEGSRE-------TLLHQVEELRTQLTK 318
IK L+ ETEK + E R L +SE R+ +LL + +L+ Q+
Sbjct: 836 FKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQA 895
Query: 319 AEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMA 378
+ + + + Q+ K + + + E R + E+ + E +++ S +
Sbjct: 896 EQDNLNDAEERCDQLIKNKIQLEAKVKE--MNERLEDEEEMNAELTAKKRKLEDECSELK 953
Query: 379 SELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERK 438
++++++ + + +KEK ++V+NLT E+ ++ ++ K +Q + +
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1013
Query: 439 HADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE----DLKLKAQESIRQWK 494
+ +++ L++ +Q + L+Q + ++ + E+ + DLKL QESI +
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL-TQESIMDLE 1072
Query: 495 LKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQ----IENLRKELNDVL 550
+LE L+K+ +++ N ++++ L QL L++ IE L +EL
Sbjct: 1073 NDKLQLEEKLKKKEFDINQ----QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128
Query: 551 TKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLD-----TIHRLESELKKQSKIQSQM 605
T RA K EKLR S + + E+ L+ T ++E K++++ Q
Sbjct: 1129 TARA--------KVEKLRSDLSRELE---EISERLEEAGGATSVQIEMNKKREAEFQKMR 1177
Query: 606 K-VEKAHLEEE--IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL 662
+ +E+A L+ E A L+K A A E+ E I +L ++ KL +E+ K L
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSVA---ELGEQIDNLQRVK----QKLEKEKSEFKLEL 1230
Query: 663 KDLSDLTAQ---AKSRDEETATII----TQLKLERDVHQRELKDLTSSLQSVKTKHEQNI 715
D++ Q AK+ E+ + + + +++ + QR L D T+ ++T++ +
Sbjct: 1231 DDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELA 1290
Query: 716 QE------LMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELT 769
++ L+ + K + LK + EE L+ + CD L E+
Sbjct: 1291 RQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ-- 1348
Query: 770 QNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILG 829
E K +L+ K E + E + ++R EE K L+ +E++
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV-- 1406
Query: 830 VIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKT---KLQWLCEELKEREN 886
+ ++A C + K K ++ + D+ D R A + K + + L E +
Sbjct: 1407 ---EAVNAKCSSLEK---TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1460
Query: 887 REKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDE 946
+ + + +L +++ R+L+ +EL L E + L+ RE ++L EE E
Sbjct: 1461 KYEESQSELESSQKEARSLS----TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1516
Query: 947 EMGSLQDRVIALE-TSTQVALDHLE 970
++G V LE Q+ ++ LE
Sbjct: 1517 QLGEGGKNVHELEKVRKQLEVEKLE 1541
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 139 bits (349), Expect = 2e-32
Identities = 219/963 (22%), Positives = 401/963 (41%), Gaps = 172/963 (17%)
Query: 184 RELSRRSRSDAETKRALEELTEKLNEAQKQEVVS-DRVERRLQELERE-------MRTER 235
+ L + +R D + +EL +K+ E Q+Q ++ R+ +LE E +R E
Sbjct: 867 KPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 925
Query: 236 ELVERRQDQLGLMSLQLQE---ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSR 292
EL ++ G ++ + QE + + EA+ E E RQ +TEK +L+Q ++
Sbjct: 926 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS----RQMQTEKKRLQQHIQELE 981
Query: 293 RLLNQSEGSRETLLHQVEELRTQ--LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRF 350
L EG+R+ L Q+E++ T+ + K E D L+ Q S++SK++ +D R
Sbjct: 982 AHLEAEEGARQKL--QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED------RL 1033
Query: 351 RRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELE 410
+ ++ EK S +++L + A +++E+ R E+ +E L +++ + EL+
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 411 NGEKQQLQMLDRLK--------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
+Q Q + L+ E+Q E E A Q+ + R A+ A +A+
Sbjct: 1094 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-GGARAQLLKSLREAQAALAEAQ--- 1149
Query: 463 SELQQSEALKEEAEKRREDL----------------KLKAQESIRQWKLKH-KKLERALE 505
+L+ + +AEK+R DL AQ+ +R + + +L++ LE
Sbjct: 1150 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1209
Query: 506 KQSE----TVDELTGKNNQILKEKDEL------------KTQLYAALQQIENLRKELNDV 549
+++ V EL ++ Q L E E KT+L A ++ LR EL+ +
Sbjct: 1210 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL-ALEAEVSELRAELSSL 1268
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
T R E+ E +L++++ D E + + + R ++EL+ S ++ + +
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Query: 610 AHLEEEIAELKKSQAQDKAKLLE--------MQESIKDLSAIRADLANKLAEEERAKKAV 661
L +E++ ++Q D +LL+ + ++ + A A L +L EE A++
Sbjct: 1329 IRLSKELSS-TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1387
Query: 662 LKDLSDLTAQ--------------------AKSRDEETATIITQL---------KLERDV 692
++L AQ A+ R A +TQ +LER
Sbjct: 1388 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1447
Query: 693 H--QRELKDLTSSLQ------SVKTKHEQNIQELMKHFK---------KEKSEAENHIRT 735
Q+EL D T L+ S K ++ +L+ K +E++EAE R
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507
Query: 736 LKA--------------ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 781
+A E LE +N A R +LE L S D + + + + E + +
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRAL--RAELEALLSSKDDVGKSVHELERACRVAEQA 1565
Query: 782 YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 841
L+ Q+ E E+ L E+A+L+L+ + L+T+ E L + D A +
Sbjct: 1566 ANDLRAQVTEL-------EDELTAAEDAKLRLEVTVQALKTQHERDL----QGRDEAGEE 1614
Query: 842 FSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE--------RENREKNLRH 893
+ ++L+ D ++ KL+ EELK +E K LR
Sbjct: 1615 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1674
Query: 894 QLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD-------E 946
++ R + E + S + +F Q E+ L + E L EE D +
Sbjct: 1675 MQAQMKELWREVEETRTSREE-IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1733
Query: 947 EMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRR 1006
+ + D V S L+ + +L LE+ + + S+SE + RY K ++
Sbjct: 1734 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE--ELEEEQSNSELLNDRYRKLLLQV 1791
Query: 1007 NSL 1009
SL
Sbjct: 1792 ESL 1794
Score = 126 bits (316), Expect = 1e-28
Identities = 196/920 (21%), Positives = 380/920 (41%), Gaps = 174/920 (18%)
Query: 160 QLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRS-DAETKRALEE------LTEKLNEAQ- 211
+L G L++ EQ + ++ +L R+ A RA +E L + L EAQ
Sbjct: 1084 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1143
Query: 212 -----KQEVVSDRVER------------RLQELEREMRTERELVERRQDQLGLMSLQLQE 254
++++ S+RV R L+ L E+ + +Q+ ++ E
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203
Query: 255 ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
K E + HE A++ ++ +L ++LE +RR E +R L +V ELR
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263
Query: 315 QLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFR----RGVEREKQDLEK------- 363
+L+ + R+ + + ++ Q Q G+ R R ++R + +LE
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1323
Query: 364 -QMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDR 422
+ +R+ S+ ++L + + ++ + + K L S+V + E + + ++
Sbjct: 1324 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-------EAEAAGLREQ 1376
Query: 423 LKEIQNHFDTCEAERKHADLQISELTRH----------AEDATKQAERYLSELQQSEALK 472
L+E + E + A Q+SE R E+A ++A R L Q A K
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436
Query: 473 EEAEKRREDLKLKAQESIRQWKL---KHKKLERALEKQSETVDELTGKNNQILKEKDELK 529
E R E + + Q+ + + + ++L LEK+ D+L + + E +
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496
Query: 530 TQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLD--- 586
+ A E +E + RAL+EE+ ++EE R ++ +A+LE + + D
Sbjct: 1497 ERAEA-----EGREREARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGK 1550
Query: 587 TIHRLESELKKQSKIQSQMKVEKAHLEEEI--AELKKSQAQDKAKLLEMQESIKDLSA-- 642
++H LE + + + ++ + LE+E+ AE K + + + L+ Q +DL
Sbjct: 1551 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE-RDLQGRD 1609
Query: 643 -----IRADLANKL--AEEER------------AKKAVLKDLSDLTAQAKSRDEETATII 683
R LA +L AE ER A+K + +L +L AQ S + +
Sbjct: 1610 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1669
Query: 684 TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESL-- 741
QL+ Q ++K+L ++ +T E+ + E+E ++ L+AE L
Sbjct: 1670 KQLR----KMQAQMKELWREVEETRTSREE--------IFSQNRESEKRLKGLEAEVLRL 1717
Query: 742 ----------------EEKNMA-KIHRGQLEK---------LKSQCDRLTEELTQNENEN 775
+ MA ++ G L K L+ + +L EEL + ++ +
Sbjct: 1718 QEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS 1777
Query: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEI 835
+ L +Y+ L Q+E +S E + E R QL+ Q+ + + G +G+E
Sbjct: 1778 ELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI-------QELRGRLGEE- 1829
Query: 836 DAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKER-------ENRE 888
DA + K ++ L+ LA+++ +L+ +E +ER E
Sbjct: 1830 DAGARARHKMTIAALE-------------SKLAQAEEQLE---QETRERILSGKLVRRAE 1873
Query: 889 KNLRHQLMLCRQ------QLRNLTENKESELQCLFQQIERQEQLLD-------EIHREKR 935
K L+ ++ + QLR+ E ++ L +Q+E E+ + RE
Sbjct: 1874 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1933
Query: 936 DLLEETQRKDEEMGSLQDRV 955
D+ E + + E+ +L++R+
Sbjct: 1934 DVTESAESMNREVTTLRNRL 1953
Score = 72.4 bits (176), Expect = 2e-12
Identities = 100/422 (23%), Positives = 179/422 (42%), Gaps = 50/422 (11%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
Q+ DL ++ L D+ + R + T +AL+ T+ + Q ++ + R+L
Sbjct: 1564 QAANDLRAQVTELEDELTAAEDAKLRLEV-TVQALK--TQHERDLQGRDEAGEERRRQLA 1620
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEA----LKKQEAKADEHEGAIKNKLRQTETEK 281
+ R+ ER+ ER+Q L + + + E LK Q A A + + +LR+ + +
Sbjct: 1621 KQLRDAEVERD-EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQM 1679
Query: 282 NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVS-------QIS 334
+L +E+E +R SRE + Q E +L E + LQ +++ Q
Sbjct: 1680 KELWREVEETRT-------SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1732
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKE 394
+ + DE + + EK+ LE ++ L ELEE + E +
Sbjct: 1733 QDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE---------EELEEEQSNSELLNDR 1783
Query: 395 KAHLASQVENLTRELE-------NGEKQQLQMLDRLKEIQNHFDTCEA-ERKHADLQISE 446
L QVE+LT EL E + Q+ +++E++ +A R + I+
Sbjct: 1784 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1843
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
L A +Q E+ E S L AEKR +++ L+ +E R +L LEK
Sbjct: 1844 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRV----ADQLRDQLEK 1899
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK 566
+ V +L + L+E +E ++ A ++ L++EL DV E+ + +
Sbjct: 1900 GNLRVKQLKRQ----LEEAEEEASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNR 1952
Query: 567 LR 568
LR
Sbjct: 1953 LR 1954
Score = 65.1 bits (157), Expect = 4e-10
Identities = 87/401 (21%), Positives = 172/401 (42%), Gaps = 60/401 (14%)
Query: 590 RLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLAN 649
RL +++K ++ Q +V +A +E + ++++ Q Q ++ E+Q + L RA
Sbjct: 861 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERA---- 915
Query: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKT 709
+LAE+ RA+ + + + + +R +E ++++L E V + E
Sbjct: 916 RLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL--EARVGEEE------------- 960
Query: 710 KHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKL--KSQCDRLTEE 767
E + + EK + HI+ L+A LE + A+ + QLEK+ +++ + E+
Sbjct: 961 -------ECSRQMQTEKKRLQQHIQELEAH-LEAEEGAR-QKLQLEKVTTEAKMKKFEED 1011
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
L E++N KL + + L+D+L E + EEE ++ + + RL+ + + +E
Sbjct: 1012 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK- 1070
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ + +EKLK G L E + Q EEL+ + R
Sbjct: 1071 ------------EEKGRQELEKLKRRLDGESSE------LQEQMVEQQQRAEELRAQLGR 1112
Query: 888 -EKNLRHQLML------CRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
E+ L+ L R QL ++ L + +E + + +++RDL EE
Sbjct: 1113 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1172
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLED 981
+ G L+D + + ++ + V E LE+
Sbjct: 1173 LEAL---RGELEDTLDSTNAQQELRSKREQEVTELKKTLEE 1210
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 139 bits (349), Expect = 2e-32
Identities = 219/963 (22%), Positives = 401/963 (41%), Gaps = 172/963 (17%)
Query: 184 RELSRRSRSDAETKRALEELTEKLNEAQKQEVVS-DRVERRLQELERE-------MRTER 235
+ L + +R D + +EL +K+ E Q+Q ++ R+ +LE E +R E
Sbjct: 859 KPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 917
Query: 236 ELVERRQDQLGLMSLQLQE---ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSR 292
EL ++ G ++ + QE + + EA+ E E RQ +TEK +L+Q ++
Sbjct: 918 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS----RQMQTEKKRLQQHIQELE 973
Query: 293 RLLNQSEGSRETLLHQVEELRTQ--LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRF 350
L EG+R+ L Q+E++ T+ + K E D L+ Q S++SK++ +D R
Sbjct: 974 AHLEAEEGARQKL--QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED------RL 1025
Query: 351 RRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELE 410
+ ++ EK S +++L + A +++E+ R E+ +E L +++ + EL+
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 411 NGEKQQLQMLDRLK--------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
+Q Q + L+ E+Q E E A Q+ + R A+ A +A+
Sbjct: 1086 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-GGARAQLLKSLREAQAALAEAQ--- 1141
Query: 463 SELQQSEALKEEAEKRREDL----------------KLKAQESIRQWKLKH-KKLERALE 505
+L+ + +AEK+R DL AQ+ +R + + +L++ LE
Sbjct: 1142 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1201
Query: 506 KQSE----TVDELTGKNNQILKEKDEL------------KTQLYAALQQIENLRKELNDV 549
+++ V EL ++ Q L E E KT+L A ++ LR EL+ +
Sbjct: 1202 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL-ALEAEVSELRAELSSL 1260
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
T R E+ E +L++++ D E + + + R ++EL+ S ++ + +
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Query: 610 AHLEEEIAELKKSQAQDKAKLLE--------MQESIKDLSAIRADLANKLAEEERAKKAV 661
L +E++ ++Q D +LL+ + ++ + A A L +L EE A++
Sbjct: 1321 IRLSKELSS-TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1379
Query: 662 LKDLSDLTAQ--------------------AKSRDEETATIITQL---------KLERDV 692
++L AQ A+ R A +TQ +LER
Sbjct: 1380 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1439
Query: 693 H--QRELKDLTSSLQ------SVKTKHEQNIQELMKHFK---------KEKSEAENHIRT 735
Q+EL D T L+ S K ++ +L+ K +E++EAE R
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499
Query: 736 LKA--------------ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 781
+A E LE +N A R +LE L S D + + + + E + +
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRAL--RAELEALLSSKDDVGKSVHELERACRVAEQA 1557
Query: 782 YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 841
L+ Q+ E E+ L E+A+L+L+ + L+T+ E L + D A +
Sbjct: 1558 ANDLRAQVTEL-------EDELTAAEDAKLRLEVTVQALKTQHERDL----QGRDEAGEE 1606
Query: 842 FSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE--------RENREKNLRH 893
+ ++L+ D ++ KL+ EELK +E K LR
Sbjct: 1607 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1666
Query: 894 QLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD-------E 946
++ R + E + S + +F Q E+ L + E L EE D +
Sbjct: 1667 MQAQMKELWREVEETRTSREE-IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1725
Query: 947 EMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRR 1006
+ + D V S L+ + +L LE+ + + S+SE + RY K ++
Sbjct: 1726 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE--ELEEEQSNSELLNDRYRKLLLQV 1783
Query: 1007 NSL 1009
SL
Sbjct: 1784 ESL 1786
Score = 126 bits (316), Expect = 1e-28
Identities = 196/920 (21%), Positives = 380/920 (41%), Gaps = 174/920 (18%)
Query: 160 QLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRS-DAETKRALEE------LTEKLNEAQ- 211
+L G L++ EQ + ++ +L R+ A RA +E L + L EAQ
Sbjct: 1076 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1135
Query: 212 -----KQEVVSDRVER------------RLQELEREMRTERELVERRQDQLGLMSLQLQE 254
++++ S+RV R L+ L E+ + +Q+ ++ E
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195
Query: 255 ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
K E + HE A++ ++ +L ++LE +RR E +R L +V ELR
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255
Query: 315 QLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFR----RGVEREKQDLEK------- 363
+L+ + R+ + + ++ Q Q G+ R R ++R + +LE
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1315
Query: 364 -QMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDR 422
+ +R+ S+ ++L + + ++ + + K L S+V + E + + ++
Sbjct: 1316 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-------EAEAAGLREQ 1368
Query: 423 LKEIQNHFDTCEAERKHADLQISELTRH----------AEDATKQAERYLSELQQSEALK 472
L+E + E + A Q+SE R E+A ++A R L Q A K
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428
Query: 473 EEAEKRREDLKLKAQESIRQWKL---KHKKLERALEKQSETVDELTGKNNQILKEKDELK 529
E R E + + Q+ + + + ++L LEK+ D+L + + E +
Sbjct: 1429 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1488
Query: 530 TQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLD--- 586
+ A E +E + RAL+EE+ ++EE R ++ +A+LE + + D
Sbjct: 1489 ERAEA-----EGREREARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGK 1542
Query: 587 TIHRLESELKKQSKIQSQMKVEKAHLEEEI--AELKKSQAQDKAKLLEMQESIKDLSA-- 642
++H LE + + + ++ + LE+E+ AE K + + + L+ Q +DL
Sbjct: 1543 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE-RDLQGRD 1601
Query: 643 -----IRADLANKL--AEEER------------AKKAVLKDLSDLTAQAKSRDEETATII 683
R LA +L AE ER A+K + +L +L AQ S + +
Sbjct: 1602 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1661
Query: 684 TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESL-- 741
QL+ Q ++K+L ++ +T E+ + E+E ++ L+AE L
Sbjct: 1662 KQLR----KMQAQMKELWREVEETRTSREE--------IFSQNRESEKRLKGLEAEVLRL 1709
Query: 742 ----------------EEKNMA-KIHRGQLEK---------LKSQCDRLTEELTQNENEN 775
+ MA ++ G L K L+ + +L EEL + ++ +
Sbjct: 1710 QEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS 1769
Query: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEI 835
+ L +Y+ L Q+E +S E + E R QL+ Q+ + + G +G+E
Sbjct: 1770 ELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI-------QELRGRLGEE- 1821
Query: 836 DAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKER-------ENRE 888
DA + K ++ L+ LA+++ +L+ +E +ER E
Sbjct: 1822 DAGARARHKMTIAALE-------------SKLAQAEEQLE---QETRERILSGKLVRRAE 1865
Query: 889 KNLRHQLMLCRQ------QLRNLTENKESELQCLFQQIERQEQLLD-------EIHREKR 935
K L+ ++ + QLR+ E ++ L +Q+E E+ + RE
Sbjct: 1866 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1925
Query: 936 DLLEETQRKDEEMGSLQDRV 955
D+ E + + E+ +L++R+
Sbjct: 1926 DVTESAESMNREVTTLRNRL 1945
Score = 72.4 bits (176), Expect = 2e-12
Identities = 100/422 (23%), Positives = 179/422 (42%), Gaps = 50/422 (11%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
Q+ DL ++ L D+ + R + T +AL+ T+ + Q ++ + R+L
Sbjct: 1556 QAANDLRAQVTELEDELTAAEDAKLRLEV-TVQALK--TQHERDLQGRDEAGEERRRQLA 1612
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEA----LKKQEAKADEHEGAIKNKLRQTETEK 281
+ R+ ER+ ER+Q L + + + E LK Q A A + + +LR+ + +
Sbjct: 1613 KQLRDAEVERD-EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQM 1671
Query: 282 NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVS-------QIS 334
+L +E+E +R SRE + Q E +L E + LQ +++ Q
Sbjct: 1672 KELWREVEETRT-------SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1724
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKE 394
+ + DE + + EK+ LE ++ L ELEE + E +
Sbjct: 1725 QDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE---------EELEEEQSNSELLNDR 1775
Query: 395 KAHLASQVENLTRELE-------NGEKQQLQMLDRLKEIQNHFDTCEA-ERKHADLQISE 446
L QVE+LT EL E + Q+ +++E++ +A R + I+
Sbjct: 1776 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1835
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
L A +Q E+ E S L AEKR +++ L+ +E R +L LEK
Sbjct: 1836 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRV----ADQLRDQLEK 1891
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK 566
+ V +L + L+E +E ++ A ++ L++EL DV E+ + +
Sbjct: 1892 GNLRVKQLKRQ----LEEAEEEASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNR 1944
Query: 567 LR 568
LR
Sbjct: 1945 LR 1946
Score = 65.1 bits (157), Expect = 4e-10
Identities = 87/401 (21%), Positives = 172/401 (42%), Gaps = 60/401 (14%)
Query: 590 RLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLAN 649
RL +++K ++ Q +V +A +E + ++++ Q Q ++ E+Q + L RA
Sbjct: 853 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERA---- 907
Query: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKT 709
+LAE+ RA+ + + + + +R +E ++++L E V + E
Sbjct: 908 RLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL--EARVGEEE------------- 952
Query: 710 KHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKL--KSQCDRLTEE 767
E + + EK + HI+ L+A LE + A+ + QLEK+ +++ + E+
Sbjct: 953 -------ECSRQMQTEKKRLQQHIQELEAH-LEAEEGAR-QKLQLEKVTTEAKMKKFEED 1003
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
L E++N KL + + L+D+L E + EEE ++ + + RL+ + + +E
Sbjct: 1004 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK- 1062
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ + +EKLK G L E + Q EEL+ + R
Sbjct: 1063 ------------EEKGRQELEKLKRRLDGESSE------LQEQMVEQQQRAEELRAQLGR 1104
Query: 888 -EKNLRHQLML------CRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
E+ L+ L R QL ++ L + +E + + +++RDL EE
Sbjct: 1105 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1164
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLED 981
+ G L+D + + ++ + V E LE+
Sbjct: 1165 LEAL---RGELEDTLDSTNAQQELRSKREQEVTELKKTLEE 1202
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 139 bits (349), Expect = 2e-32
Identities = 219/963 (22%), Positives = 401/963 (41%), Gaps = 172/963 (17%)
Query: 184 RELSRRSRSDAETKRALEELTEKLNEAQKQEVVS-DRVERRLQELERE-------MRTER 235
+ L + +R D + +EL +K+ E Q+Q ++ R+ +LE E +R E
Sbjct: 900 KPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 958
Query: 236 ELVERRQDQLGLMSLQLQE---ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSR 292
EL ++ G ++ + QE + + EA+ E E RQ +TEK +L+Q ++
Sbjct: 959 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS----RQMQTEKKRLQQHIQELE 1014
Query: 293 RLLNQSEGSRETLLHQVEELRTQ--LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRF 350
L EG+R+ L Q+E++ T+ + K E D L+ Q S++SK++ +D R
Sbjct: 1015 AHLEAEEGARQKL--QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED------RL 1066
Query: 351 RRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELE 410
+ ++ EK S +++L + A +++E+ R E+ +E L +++ + EL+
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 411 NGEKQQLQMLDRLK--------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
+Q Q + L+ E+Q E E A Q+ + R A+ A +A+
Sbjct: 1127 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-GGARAQLLKSLREAQAALAEAQ--- 1182
Query: 463 SELQQSEALKEEAEKRREDL----------------KLKAQESIRQWKLKH-KKLERALE 505
+L+ + +AEK+R DL AQ+ +R + + +L++ LE
Sbjct: 1183 EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLE 1242
Query: 506 KQSE----TVDELTGKNNQILKEKDEL------------KTQLYAALQQIENLRKELNDV 549
+++ V EL ++ Q L E E KT+L A ++ LR EL+ +
Sbjct: 1243 EETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL-ALEAEVSELRAELSSL 1301
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
T R E+ E +L++++ D E + + + R ++EL+ S ++ + +
Sbjct: 1302 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361
Query: 610 AHLEEEIAELKKSQAQDKAKLLE--------MQESIKDLSAIRADLANKLAEEERAKKAV 661
L +E++ ++Q D +LL+ + ++ + A A L +L EE A++
Sbjct: 1362 IRLSKELSS-TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERA 1420
Query: 662 LKDLSDLTAQ--------------------AKSRDEETATIITQL---------KLERDV 692
++L AQ A+ R A +TQ +LER
Sbjct: 1421 GRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR 1480
Query: 693 H--QRELKDLTSSLQ------SVKTKHEQNIQELMKHFK---------KEKSEAENHIRT 735
Q+EL D T L+ S K ++ +L+ K +E++EAE R
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540
Query: 736 LKA--------------ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 781
+A E LE +N A R +LE L S D + + + + E + +
Sbjct: 1541 ARALSLTRALEEEQEAREELERQNRAL--RAELEALLSSKDDVGKSVHELERACRVAEQA 1598
Query: 782 YQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKT 841
L+ Q+ E E+ L E+A+L+L+ + L+T+ E L + D A +
Sbjct: 1599 ANDLRAQVTEL-------EDELTAAEDAKLRLEVTVQALKTQHERDL----QGRDEAGEE 1647
Query: 842 FSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE--------RENREKNLRH 893
+ ++L+ D ++ KL+ EELK +E K LR
Sbjct: 1648 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1707
Query: 894 QLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKD-------E 946
++ R + E + S + +F Q E+ L + E L EE D +
Sbjct: 1708 MQAQMKELWREVEETRTSREE-IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1766
Query: 947 EMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRR 1006
+ + D V S L+ + +L LE+ + + S+SE + RY K ++
Sbjct: 1767 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE--ELEEEQSNSELLNDRYRKLLLQV 1824
Query: 1007 NSL 1009
SL
Sbjct: 1825 ESL 1827
Score = 126 bits (316), Expect = 1e-28
Identities = 196/920 (21%), Positives = 380/920 (41%), Gaps = 174/920 (18%)
Query: 160 QLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRS-DAETKRALEE------LTEKLNEAQ- 211
+L G L++ EQ + ++ +L R+ A RA +E L + L EAQ
Sbjct: 1117 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1176
Query: 212 -----KQEVVSDRVER------------RLQELEREMRTERELVERRQDQLGLMSLQLQE 254
++++ S+RV R L+ L E+ + +Q+ ++ E
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236
Query: 255 ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRT 314
K E + HE A++ ++ +L ++LE +RR E +R L +V ELR
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296
Query: 315 QLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFR----RGVEREKQDLEK------- 363
+L+ + R+ + + ++ Q Q G+ R R ++R + +LE
Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1356
Query: 364 -QMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDR 422
+ +R+ S+ ++L + + ++ + + K L S+V + E + + ++
Sbjct: 1357 AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-------EAEAAGLREQ 1409
Query: 423 LKEIQNHFDTCEAERKHADLQISELTRH----------AEDATKQAERYLSELQQSEALK 472
L+E + E + A Q+SE R E+A ++A R L Q A K
Sbjct: 1410 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1469
Query: 473 EEAEKRREDLKLKAQESIRQWKL---KHKKLERALEKQSETVDELTGKNNQILKEKDELK 529
E R E + + Q+ + + + ++L LEK+ D+L + + E +
Sbjct: 1470 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1529
Query: 530 TQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLD--- 586
+ A E +E + RAL+EE+ ++EE R ++ +A+LE + + D
Sbjct: 1530 ERAEA-----EGREREARALSLTRALEEEQ-EAREELERQNRALRAELEALLSSKDDVGK 1583
Query: 587 TIHRLESELKKQSKIQSQMKVEKAHLEEEI--AELKKSQAQDKAKLLEMQESIKDLSA-- 642
++H LE + + + ++ + LE+E+ AE K + + + L+ Q +DL
Sbjct: 1584 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE-RDLQGRD 1642
Query: 643 -----IRADLANKL--AEEER------------AKKAVLKDLSDLTAQAKSRDEETATII 683
R LA +L AE ER A+K + +L +L AQ S + +
Sbjct: 1643 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1702
Query: 684 TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESL-- 741
QL+ Q ++K+L ++ +T E+ + E+E ++ L+AE L
Sbjct: 1703 KQLR----KMQAQMKELWREVEETRTSREE--------IFSQNRESEKRLKGLEAEVLRL 1750
Query: 742 ----------------EEKNMA-KIHRGQLEK---------LKSQCDRLTEELTQNENEN 775
+ MA ++ G L K L+ + +L EEL + ++ +
Sbjct: 1751 QEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNS 1810
Query: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEI 835
+ L +Y+ L Q+E +S E + E R QL+ Q+ + + G +G+E
Sbjct: 1811 ELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI-------QELRGRLGEE- 1862
Query: 836 DAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKER-------ENRE 888
DA + K ++ L+ LA+++ +L+ +E +ER E
Sbjct: 1863 DAGARARHKMTIAALE-------------SKLAQAEEQLE---QETRERILSGKLVRRAE 1906
Query: 889 KNLRHQLMLCRQ------QLRNLTENKESELQCLFQQIERQEQLLD-------EIHREKR 935
K L+ ++ + QLR+ E ++ L +Q+E E+ + RE
Sbjct: 1907 KRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELE 1966
Query: 936 DLLEETQRKDEEMGSLQDRV 955
D+ E + + E+ +L++R+
Sbjct: 1967 DVTESAESMNREVTTLRNRL 1986
Score = 72.4 bits (176), Expect = 2e-12
Identities = 100/422 (23%), Positives = 179/422 (42%), Gaps = 50/422 (11%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
Q+ DL ++ L D+ + R + T +AL+ T+ + Q ++ + R+L
Sbjct: 1597 QAANDLRAQVTELEDELTAAEDAKLRLEV-TVQALK--TQHERDLQGRDEAGEERRRQLA 1653
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEA----LKKQEAKADEHEGAIKNKLRQTETEK 281
+ R+ ER+ ER+Q L + + + E LK Q A A + + +LR+ + +
Sbjct: 1654 KQLRDAEVERD-EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQM 1712
Query: 282 NQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVS-------QIS 334
+L +E+E +R SRE + Q E +L E + LQ +++ Q
Sbjct: 1713 KELWREVEETRT-------SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1765
Query: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKE 394
+ + DE + + EK+ LE ++ L ELEE + E +
Sbjct: 1766 QDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE---------EELEEEQSNSELLNDR 1816
Query: 395 KAHLASQVENLTRELE-------NGEKQQLQMLDRLKEIQNHFDTCEA-ERKHADLQISE 446
L QVE+LT EL E + Q+ +++E++ +A R + I+
Sbjct: 1817 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1876
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
L A +Q E+ E S L AEKR +++ L+ +E R +L LEK
Sbjct: 1877 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRV----ADQLRDQLEK 1932
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK 566
+ V +L + L+E +E ++ A ++ L++EL DV E+ + +
Sbjct: 1933 GNLRVKQLKRQ----LEEAEEEASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNR 1985
Query: 567 LR 568
LR
Sbjct: 1986 LR 1987
Score = 65.1 bits (157), Expect = 4e-10
Identities = 87/401 (21%), Positives = 172/401 (42%), Gaps = 60/401 (14%)
Query: 590 RLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLAN 649
RL +++K ++ Q +V +A +E + ++++ Q Q ++ E+Q + L RA
Sbjct: 894 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERA---- 948
Query: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKT 709
+LAE+ RA+ + + + + +R +E ++++L E V + E
Sbjct: 949 RLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL--EARVGEEE------------- 993
Query: 710 KHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKL--KSQCDRLTEE 767
E + + EK + HI+ L+A LE + A+ + QLEK+ +++ + E+
Sbjct: 994 -------ECSRQMQTEKKRLQQHIQELEAH-LEAEEGAR-QKLQLEKVTTEAKMKKFEED 1044
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
L E++N KL + + L+D+L E + EEE ++ + + RL+ + + +E
Sbjct: 1045 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK- 1103
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ + +EKLK G L E + Q EEL+ + R
Sbjct: 1104 ------------EEKGRQELEKLKRRLDGESSE------LQEQMVEQQQRAEELRAQLGR 1145
Query: 888 -EKNLRHQLML------CRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEE 940
E+ L+ L R QL ++ L + +E + + +++RDL EE
Sbjct: 1146 KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEE 1205
Query: 941 TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLED 981
+ G L+D + + ++ + V E LE+
Sbjct: 1206 LEAL---RGELEDTLDSTNAQQELRSKREQEVTELKKTLEE 1243
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 139 bits (349), Expect = 2e-32
Identities = 226/1006 (22%), Positives = 428/1006 (42%), Gaps = 158/1006 (15%)
Query: 44 ITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRS 103
+ + +Q+ + N V + ++ E ++ IE L +++ L +RL+ S
Sbjct: 156 VAAHIQEVTHNQENVFDL--QWMEVTDMSQEDIEPLLKNMA-----LHLKRLIDERDEHS 208
Query: 104 ISVTSLSASDLDGGTGSELHHFP--PTSPLKDYGDPQGIKRMRSRTGV------------ 149
++ LS + DG LH P +S G P G+KR SR +
Sbjct: 209 ETIIELS-EERDG-----LHFLPHASSSAQSPCGSP-GMKRTESRQHLSVELADAKAKIR 261
Query: 150 RFVQETDDMT-QLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLN 208
R QE ++ T QL Q L + E RL + N L +RS + L+ L EK
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDELDALREKAV 320
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE-HE 267
K E R + RL ++E EL E Q L ++ L++ L+ A++D+ HE
Sbjct: 321 RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHE 379
Query: 268 GA-----IKNKLRQTETEKN----QLEQELELSRRLLNQSEGSRETLLH---QVEELRTQ 315
+K KL E E++ ++E+ +E + L + S + LH ++E++
Sbjct: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
Query: 316 LTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFS 375
+E +K L H+V++++ + +E E Q L K + +LR ++
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRL-------------LKLEMENQSLTKTVEELRTTVD-- 484
Query: 376 AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435
+E + + +KE L+ +VE L E+ EKQ LQ C+
Sbjct: 485 ----SVEGNASKILKMEKENQRLSKKVEILENEIVQ-EKQSLQ-------------NCQN 526
Query: 436 ERKHADLQISELTRHAEDATKQAERYLSELQQ-SEALKEEAEKRREDLKLKAQESIRQWK 494
K + ++L + E + +ER + L+Q +E L + R+ ++ A+ ++ +
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
Query: 495 LKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRA 554
++K L ++++ S + ++ + QI KE + K + ++ E L EL+ + +
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG----ERAEELENELHHLEKENE 642
Query: 555 LQEEELHSKE---EKLRDIKSHQADLELE---VKNSLDTIHRLESELKKQSKIQSQMKVE 608
L ++++ + + EK+ ++ ++LE E +K +LD+ L +L+ K SQ+ E
Sbjct: 643 LLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
Query: 609 KAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDL 668
L + LK + K+ ++Q K+L + E+E+ KK + +L
Sbjct: 703 NLELRRNVESLKCASM----KMAQLQLENKELES----------EKEQLKKGL-----EL 743
Query: 669 TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQEL-MKHFKKEKS 727
+ + E L +E Q+ L++ +Q + E +Q+L M++ +K+
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL----ESELQDLEMENQTLQKN 799
Query: 728 EAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKD 787
E I + + E LE++N + L+ + +L ++ Q E ENK+L+ + +
Sbjct: 800 LEELKISSKRLEQLEKEN---------KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 788 QLEEREKHI-SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDA-ACKTFSKD 845
LEE I ++E+E+ +E + + + E E+E+ V ID T +D
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 846 SV-EKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRN 904
V EKLK D+ H K + L +E + ++R K L +L L+
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE-QSTDDRYKLLESKL---ESTLKK 966
Query: 905 LTENKESELQCLFQQIERQ----EQLLDEIHREKRDLLEETQRKDEE------------- 947
E KE ++ L ++E +QL E+ K++ QR+DEE
Sbjct: 967 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1026
Query: 948 -------------MGSLQDRVIALETSTQVALDHLESVPEKLSLLE 980
+ ++DR+I +E + +++ +L LE
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072
Score = 125 bits (313), Expect = 3e-28
Identities = 200/1008 (19%), Positives = 415/1008 (41%), Gaps = 136/1008 (13%)
Query: 67 EYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFP 126
E N Q A H E +E+ +D+ + + L+ + ++ + + D G EL
Sbjct: 381 EKENLQLKAKLHDME-MERDMDRKKIEELMEEN--MTLEMAQKQSMDESLHLGWELEQIS 437
Query: 127 PTSPLKDYGDPQ---GIKRMRSRTGVRFVQETDDMTQ-----------LHGFHQSLRDLS 172
TS L + + + S ++ E +T+ + G + +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 173 SEQIRLG---DDFNRELSRRSRSDAETKRALEELTEKLNEAQKQ-EVVSDRVERRLQELE 228
E RL + E+ + +S + ++L ++ + +K E + + ER+++ LE
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 229 REMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQEL 288
+E + V + + + + + ++K+ E +KL + E EK Q+++EL
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 289 ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDW 348
E + +G R EEL +L E + + LQ +++ + +
Sbjct: 618 EHYKE-----KGER------AEELENELHHLEKENELLQKKITNLKITCEKIE------- 659
Query: 349 RFRRGVEREKQDLEKQMSDLRVQLN-FSAMASELEEVKRCMERKDKEKAHLASQVENL-- 405
+E+E +LE++ L+ L+ F + +LE +++ + D+E L VE+L
Sbjct: 660 ----ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 406 -----------TRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDA 454
+ELE+ ++Q + L+ LK + E + D++ L + E++
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 455 TKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDEL 514
K+ ++ SELQ E + +K E+LK+ ++ + Q + ++K LE+ + + +L
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKR-LEQLEKENKSLEQETSQLEKDKKQL 834
Query: 515 TGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQ 574
+N ++ ++ + T L +I NL KE + + + +E +L++++
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC----VRLKELEKEN 890
Query: 575 ADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQ 634
+L + T+ L +L + QM + L E+ ++ +K +LL +
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI----GLNKERLLHDE 946
Query: 635 ESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQ 694
+S D + L +KL E K L+ + A ++R EE+ QL+ E
Sbjct: 947 QSTDDRYKL---LESKL---ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE----- 995
Query: 695 RELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQL 754
L++VK +E K++ + E +++ S E+ + +
Sbjct: 996 ---------LKTVKKNYEA---------LKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 755 EKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLK 814
+L DRL E E N L+ + Q LK QL++ E + + + ++ + L+
Sbjct: 1038 RELLKVKDRLIEV----ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1093
Query: 815 DQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKL 874
+Q L+T Q + L V +++ + + + L SS E++ +
Sbjct: 1094 EQNTTLQT-QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS------------LENENE- 1139
Query: 875 QWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREK 934
+KERE+ K+L L+ ++L L E + SE + L + + + E
Sbjct: 1140 ----SVIKEREDL-KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1194
Query: 935 RDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLED------FKDFRDS 988
RDL + + ++ G L+D L+ + V ++ LLE+ +++
Sbjct: 1195 RDLEDRYNQLLKQKGQLED------------LEKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 989 CSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTR 1036
C ++R + YS+ LQ + K + K ++T LE ++
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
Score = 117 bits (293), Expect = 6e-26
Identities = 192/865 (22%), Positives = 379/865 (43%), Gaps = 115/865 (13%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA-----QKQEVVSDRV 220
Q+ ++LS + ++ + + + + LE+ E LN+ Q+ ++ +
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA--- 578
Query: 221 ERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGA--IKNKLRQTE 278
E R++++E+E + E ++ +L + + ++ K+ E ++ E A ++N+L E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 279 TEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQS 338
E N+L Q+ + ++ + + E ++E +L K K L Q+ + K+ S
Sbjct: 639 KE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697
Query: 339 NYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMER-----KDK 393
+E E RR VE K M ++QL + SE E++K+ +E K
Sbjct: 698 QLDEENLE---LRRNVESLKC---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Query: 394 EKAHLASQ---VEN--LTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
E+ ++ Q +EN L + LEN K+ Q+ L++++ T + + +L+IS +
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE--ELKIS--S 807
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERA-LEKQ 507
+ E K+ + E Q E K++ EK E+ +L+ Q I+ L+ ++ LEK+
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEK--ENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 508 SETVDELTG-------KNNQILKEKDELKTQLYAALQQIENLRKEL-----------NDV 549
++T+ + G + ++ KE EL + ++ + LR++L ND+
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 550 ------LTKRALQEEELHSKEEKLRD-IKSHQADLELEVKNSLDT----IHRLESELKKQ 598
L K L +E L E+ D K ++ LE +K SL+ I LE+ L++
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 599 SKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLL---------------EMQESIKDLSAI 643
+ Q++ E +++ LK Q QD+ +++ E QE+ ++L +
Sbjct: 986 TNYNQQLRQELKTVKKNYEALK--QRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1043
Query: 644 RADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQ-LKLERDVHQRELKDLTS 702
+ ++L E ER + + L Q K + + + Q L L+R + ++ T
Sbjct: 1044 K----DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
Query: 703 SLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCD 762
Q+ K + E + + + +N ++ SLE +N + I + E LKS D
Sbjct: 1100 QTQNAKLQVENSTL----NSQSTSLMNQNAQLLIQQSSLENENESVIK--EREDLKSLYD 1153
Query: 763 RLTEELTQNENENKKLKLKYQCLKDQ---LEEREKHISIE----EEHLRRMEEARLQLKD 815
L ++ + E +++ +Y+ L + L+ K++ +E E+ ++ + + QL+D
Sbjct: 1154 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1213
Query: 816 QLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDI----------HYDPHR 865
L+ EQE +L + K + + K E ++ + + H +
Sbjct: 1214 LEKMLKVEQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272
Query: 866 WLAESK---TKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIER 922
L SK T+L+ +LKE+ + +L + L L N E E + L QI+
Sbjct: 1273 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1332
Query: 923 ---QEQLLDEIHREKRDLLEETQRK 944
Q + L E + E +DL QR+
Sbjct: 1333 LMLQNRTLLEQNMESKDLFHVEQRQ 1357
Score = 99.8 bits (247), Expect = 1e-20
Identities = 188/893 (21%), Positives = 373/893 (41%), Gaps = 154/893 (17%)
Query: 35 VEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQR 94
V+ + + + +D + Q+++ + RE S Q +E E L Q++ LR +
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 95 LLRNSGG------------RSISVTSLSASDLD---GGTGSELHHFPPTSPLKDYGDPQG 139
+ SI TS S ++ EL H+ +G
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE----------KG 624
Query: 140 IKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA 199
+ + +++ +++ Q + + + E+I + N EL R +R +T +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKI---TCEKIEALEQENSELERENRKLKKTLDS 681
Query: 200 LEELTEKLNEAQKQEVVSDR----VERRLQELE------REMRTERELVERRQDQLGLMS 249
+ LT +L +K+ D + R ++ L+ +++ E + +E ++QL
Sbjct: 682 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 250 LQLQEALKKQEAKADEHEGA-IKN-KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLH 307
L+ + KK E ++G I+N +L++T N+ Q+LE L E +TL
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE---LQDLEMENQTLQK 798
Query: 308 QVEELRT---QLTKAEGDRKGLQHQVSQISK-------------QQSNYQDEQGEDWRFR 351
+EEL+ +L + E + K L+ + SQ+ K QQ+ +D E+ +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 352 RG-VEREKQDLEKQMSDLRVQ-LNFSAMASELEE-VKRCME--------RKDKEKAHLAS 400
G +E+E + L K++ + + + E +E VKR R+D L +
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 401 Q-----VENLTRELENGEKQQLQML-------DRLKEIQNHFD-TCEAERKHADLQISEL 447
Q +E LT ELE + ++L DR K +++ + T + + + +I+ L
Sbjct: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978
Query: 448 TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESI------RQWKLKHKKLE 501
E++T ++ EL+ + EA K+R+D + Q S +W+ + ++
Sbjct: 979 EARLEESTNYNQQLRQELKTVKK-NYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH 561
R L K + + E+ N + EK LKTQL Q NL+ ++ ALQ + +
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI------LALQRQTV- 1090
Query: 562 SKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKK 621
S +E+ +++ A +L+V+NS T++ + L Q+ +Q+ ++++ LE E + K
Sbjct: 1091 SLQEQNTTLQTQNA--KLQVENS--TLNSQSTSLMNQN---AQLLIQQSSLENENESVIK 1143
Query: 622 SQAQDKA---KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLK-------DLSDLTAQ 671
+ K+ L++ E ++ L +A L + K+ K DL D Q
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 672 AKSRDEETATIITQLKLERDVHQRELKD------------------------LTSSLQSV 707
+ + + LK+E++ E K+ L + +
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263
Query: 708 KTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
+T H+ N++ L+ + K E++ E LK E ++ ++ KL +QC+ L++
Sbjct: 1264 QTDHK-NLKSLLNNSKLEQTRLEAEFSKLK-EQYQQLDITST------KLNNQCELLSQL 1315
Query: 768 LTQNENENKKLKLKYQ--------CLKDQLEEREKHISIEEEHLRRMEEARLQ 812
E EN+ L + Q L+ +E ++ + +++ ++ E R Q
Sbjct: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQ 1368
Score = 92.4 bits (228), Expect = 2e-18
Identities = 145/647 (22%), Positives = 273/647 (42%), Gaps = 75/647 (11%)
Query: 403 ENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
++L+ EL + + + ++ L+E C+ E + ++++ L + + A
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 463 SELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ +AL+E+A R D KL+++ S ++K+ +E V+EL N +L
Sbjct: 307 MYRDELDALREKAV--RVD-KLESEVS------RYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 523 KEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVK 582
+ K L+ QL E R + ++LH E++ +K+ D+E+E
Sbjct: 358 ETKTMLEDQL-------EGTRA-----------RSDKLHELEKENLQLKAKLHDMEMERD 399
Query: 583 NSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSA 642
I L E Q Q E HL E+ ++ ++ +A + + +L+
Sbjct: 400 MDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT- 458
Query: 643 IRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTS 702
+++L + E +++ K + +L S + + I LK+E++ + K
Sbjct: 459 -----SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSKKVEIL 510
Query: 703 SLQSVKTKHE-QNIQELMKHFKKEKSEAENHIRTLKAES------LEEKNMAKIHRGQLE 755
+ V+ K QN Q L K KEK++ E I TL+ S LE++N H Q
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE---HLNQTV 567
Query: 756 KLKSQCDRLTEELTQNENENKKLKLKYQCLKD------QLEEREKHISIEEEHLRRMEEA 809
Q +++ E + E K+ K+ ++ +K+ ++E ++ I E EH + E
Sbjct: 568 SSLRQRSQISAEARVKDIE-KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 810 RLQLKDQLLCLETEQESI------LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDP 863
+L+++L LE E E + L + ++I+A + S+ E K+ +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
Query: 864 HRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESE--------LQC 915
+ + K Q E L+ R N E + + + QL N E E L+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 916 LFQQIERQE---QLLDEIHREKRDLLEETQRKDEEMGS-LQDRVIALETST-QVALDHLE 970
F++ ER E Q LD ++ + LE + +K +++ S LQD + +E T Q L+ L+
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD--LEMENQTLQKNLEELK 804
Query: 971 SVPEKLSLLE-DFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDT 1016
++L LE + K S E+ + K R +D T
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Score = 78.2 bits (191), Expect = 4e-14
Identities = 133/671 (19%), Positives = 281/671 (41%), Gaps = 77/671 (11%)
Query: 418 QMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEA---LKEE 474
+ ++R++ + FDT A H I E+T + E+ ++++ Q + LK
Sbjct: 140 EFIERIQGLD--FDTKAAVAAH----IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNM 193
Query: 475 AE--KRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL 532
A KR D + + E+I + + L S + + + L +L
Sbjct: 194 ALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL 253
Query: 533 YAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNS---LDTIH 589
A +I LR+EL + + ++EL E +L+ ++ +L + +++ D +
Sbjct: 254 ADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD 313
Query: 590 RLESELKKQSKIQSQMKVEKAHLEE------EIAELKKSQAQDKAKLLEMQESIKDL--- 640
L + + K++S++ K L + + ELK +D LLE + ++D
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----EDNQVLLETKTMLEDQLEG 369
Query: 641 SAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDL 700
+ R+D ++L +E KA L D+ + + EE L++ + E L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 701 TSSLQSVKTKHE--QNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLK 758
L+ + E + Q+ + H E + + R LK E +E +++ K +E+L+
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSS----RLLKLE-MENQSLTK----TVEELR 480
Query: 759 SQCDRL---TEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKD 815
+ D + ++ + E EN++L K + L++++ + ++ + + + + + + QL+
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 816 QLLCLETEQESILGVIGKEIDAACKTFSK-DSVEKLKVFSSGPDIHYDP---HRWLAESK 871
+ L E + ++ +E + +T S ++ + DI + H + E+
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 872 TKLQWL----------CEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIE 921
+KL + E KE+ R + L ++L ++ L + K + L+ ++IE
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIE 659
Query: 922 RQEQLLDEIHREKR-----------------DLLEETQRKDEEMGSLQDRVIALETST-- 962
EQ E+ RE R L +E + DEE L+ V +L+ ++
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
Query: 963 --QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRT 1020
Q+ L++ E EK L + + + S +ER + Y + LQ +++ +
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
Query: 1021 KSFKGDRTFLE 1031
+ + + LE
Sbjct: 780 QQLESELQDLE 790
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 138 bits (347), Expect = 3e-32
Identities = 215/959 (22%), Positives = 404/959 (42%), Gaps = 129/959 (13%)
Query: 150 RFVQETDDMTQLHGFHQSLRDLSSEQIRLG-------------DDFNRELSRRSRSDAET 196
R +E + + H Q+L DL +E+ R+ +D L + + +T
Sbjct: 1040 RLTKEKKALQEAH--QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDT 1097
Query: 197 KRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEAL 256
+RA +L L Q+ + + +++L+E ++ +E + R + L+ Q+Q+ +
Sbjct: 1098 ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKI 1157
Query: 257 KKQEAKADEHEGAIK-NKLRQTETEKNQLE--QEL-ELSRRLL---NQSEGSRETLLHQV 309
K+ +A+A+E E ++ + + EK + E +EL ELS RL S G RE +
Sbjct: 1158 KELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKRE 1217
Query: 310 EELRTQLTKAEGDRKGLQHQ--VSQISKQQSNYQDEQGED----WRFRRGVEREKQDLEK 363
EL + E + L+H+ V+ + ++Q+ E GE R R+ +E+EK +L
Sbjct: 1218 AELGR--LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRM 1275
Query: 364 QMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRL 423
++ DL + A E K C +D + + +VE L R+L + Q+ ++
Sbjct: 1276 EVDDLAANVETLTRAKASAE-KLCRTYED-QLSEAKIKVEELQRQLADASTQRGRLQTES 1333
Query: 424 KEIQNHFDTCEA-------ERKHADLQISELTRHAEDATK---------QAERYLSELQQ 467
E+ + E + A + EL R E+ +K QA R+ +L +
Sbjct: 1334 GELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLR 1393
Query: 468 SEALKEEAEKRREDLKL--KAQESIRQWKLKH---------------KKLERALEKQSET 510
E +EEAE + E +L KA + QW+ K+ KKL L++ E
Sbjct: 1394 -EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEG 1452
Query: 511 VDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH---SKEEKL 567
V+ K + + K K L+T+ ++E AL +++ H + EE+
Sbjct: 1453 VEAANAKCSSLEKAKLRLQTESEDVTLELERATS------AAAALDKKQRHLERALEERR 1506
Query: 568 RDIKSHQADLELEVKNS--LDT-IHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA 624
R + Q +LE + S L T + RL ++ + +K E +L+EEI++L +
Sbjct: 1507 RQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVS 1566
Query: 625 QDKAKLLEMQESIKDLSAIRADLANKLAE-------EERAKKAVLKDLSDLTAQA----K 673
+ E++++ K L ++++ L E EE + +LS + A+
Sbjct: 1567 LSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLA 1626
Query: 674 SRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHI 733
+DEE A + R HQR ++ L +SL + +T+ L K + + ++ E +
Sbjct: 1627 EKDEECANL-------RRNHQRAVESLQASLDA-ETRARNEALRLKKKMEGDLNDLELQL 1678
Query: 734 RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEERE 793
++ E + ++ + QL++ ++ D + + + L+ + L +LEE
Sbjct: 1679 GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELR 1738
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
+ E R E+ L+ ++L L ++ +L K+++A S + E +
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQ-KKKLEADLAQLSGEVEEAAQ-- 1795
Query: 854 SSGPDIHYDPHRWLAESKTK-----LQWLCEELKERENREKNLRHQLMLCRQQLRNLTEN 908
R AE K K + EELK+ ++ +L Q +R L
Sbjct: 1796 ----------ERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQAR 1845
Query: 909 KESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEE--MGSLQDRVIALETSTQVAL 966
E Q + ++Q Q L+ RE L+ Q+K E G + E + Q
Sbjct: 1846 LEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEE 1905
Query: 967 D-----HLESVPEKL-SLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYR 1019
D ++ + +KL S ++ +K R + ++ + +KYR QH DD + R
Sbjct: 1906 DRKNLARMQDLVDKLQSKVKSYK--RQFEEAEQQANTNLAKYR----KAQHELDDAEER 1958
Score = 118 bits (296), Expect = 3e-26
Identities = 162/767 (21%), Positives = 323/767 (42%), Gaps = 89/767 (11%)
Query: 223 RLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKN 282
+++ L R + E EL R + GL AL EAK E L +T
Sbjct: 884 KMKPLLRSAQAEEELAALRAELRGLRG-----ALAAAEAKRQE--------LEETHVSIT 930
Query: 283 QLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQD 342
Q + +L L + + E H + + + QL + +V ++S++ + ++
Sbjct: 931 QEKNDLALQLQAEQDNLADAEERCHLLIKSKVQL----------EGKVKELSERLEDEEE 980
Query: 343 EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQV 402
+ RR +E E +L+K + DL++ L + +KEK ++V
Sbjct: 981 VNADLAARRRKLEDECTELKKDIDDLKLTL----------------AKAEKEKQATENKV 1024
Query: 403 ENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYL 462
+NLT E+ ++ ++ K +Q + + + ++S LT+ +Q E
Sbjct: 1025 KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLE 1084
Query: 463 SELQQSEALKEEAEKRRE----DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKN 518
L+Q + L+ + E+ + DLKL QES+ ++LE L+K+ + +L+
Sbjct: 1085 CSLEQEKKLRMDTERAKRKLEGDLKL-TQESVADAAQDKQQLEEKLKKKDSELSQLS--- 1140
Query: 519 NQILKEKDE--LKTQLYAALQQI----ENLRKELNDVLTKRALQEEELHSKEEKLRDIKS 572
L+ +DE L Q+ ++++ E L +EL RA E++ +L ++
Sbjct: 1141 ---LRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 573 HQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLE 632
+ + + E+EL +++ +++ E +A L++ QA+ A E
Sbjct: 1198 RLEEAGGASAGQREGCRKREAEL---GRLRRELEEAALRHEATVAALRRKQAEGAA---E 1251
Query: 633 MQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL---KLE 689
+ E + L +R L + +E + ++ LT S ++ T QL K++
Sbjct: 1252 LGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 690 RDVHQRELKDLTSS---LQSVKTKHEQNIQE---LMKHFKKEKSEAENHIRTLKAESLEE 743
+ QR+L D ++ LQ+ + + ++E L+ + K+ A + L+ + EE
Sbjct: 1312 VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE 1371
Query: 744 KNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHL 803
++ L+ CD L E+ E + +L+ K E + E + +
Sbjct: 1372 SKAKSALAHAVQALRHDCDLLREQ--HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 804 RRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDP 863
+R EE K L L+ +E + + +A C + K KL++ + D+ +
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGV-----EAANAKCSSLEK---AKLRLQTESEDVTLEL 1481
Query: 864 HRWLAESKT---KLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQI 920
R + + K + L L+ER +E+ ++ +L +++ R L +EL L
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGL----GTELFRLRHGH 1537
Query: 921 ERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALD 967
E + L+ + RE ++L EE +++ SL + I T+ AL+
Sbjct: 1538 EEALEALETLKRENKNLQEEISDLTDQV-SLSGKSIQELEKTKKALE 1583
Score = 109 bits (272), Expect = 2e-23
Identities = 156/647 (24%), Positives = 294/647 (45%), Gaps = 76/647 (11%)
Query: 186 LSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQL 245
L + +AE + L+ L K N Q R E + RTE EL E ++
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQW-------RSKYEADAIQRTE-ELEEAKKK-- 1441
Query: 246 GLMSLQLQEALKKQEAKADEHEGAIKNKLR-QTETEKNQLEQELELSR-----RLLNQSE 299
++L+LQEA + EA + K KLR QTE+E LE E S + E
Sbjct: 1442 --LALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLE 1499
Query: 300 GSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQ 359
+ E Q EE++ +L A+ + +GL ++ ++ E ++RE +
Sbjct: 1500 RALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE-------EALEALETLKRENK 1552
Query: 360 DLEKQMSDLRVQLNFSAMA-SELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQ 418
+L++++SDL Q++ S + ELE+ K+ +E EK+ + + +E LE E + L+
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEG---EKSEIQAALEEAEGALELEETKTLR 1609
Query: 419 MLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATK--QAERYLSELQQSEAL--KEE 474
+ L +++ D AE+ D + + L R+ + A + QA ++EAL K++
Sbjct: 1610 IQLELSQVKAEVDRKLAEK---DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKK 1666
Query: 475 AEKRREDLKLKAQESIRQW---KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQ 531
E DL+L+ + RQ + + ++ L+++ DE ++ ++ L+ +
Sbjct: 1667 MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERR 1726
Query: 532 LYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRL 591
++E LR L R L E+EL E+L + S L L+ +L
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGL-------LNQKKKL 1779
Query: 592 ESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA-QDKAKLLEMQESIKDLSAIRADLANK 650
E++L + S +VE+A E AE K +A D A + E + +D SA
Sbjct: 1780 EADLAQLSG-----EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSA-------- 1826
Query: 651 LAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTK 710
ER KK + + + +L QA+ + E A + K + + + ++++L + L + + K
Sbjct: 1827 --HLERMKKTLEQTVREL--QARLEEAEQAALRGGKKQVQKL-EAKVRELEAELDAEQKK 1881
Query: 711 HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770
H + ++ + KH ++ K A +AE + KN+A++ + ++KL+S+ + +
Sbjct: 1882 HAEALKGVRKHERRVKELA------YQAEE-DRKNLARM-QDLVDKLQSKVKSYKRQFEE 1933
Query: 771 NENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQL 817
E + KY+ + +L++ E+ + E ++ R + +D L
Sbjct: 1934 AEQQANTNLAKYRKAQHELDDAEERADMAETQANKL---RARTRDAL 1977
Score = 107 bits (266), Expect = 8e-23
Identities = 136/650 (20%), Positives = 277/650 (42%), Gaps = 90/650 (13%)
Query: 157 DMTQLHGFHQSLRDLSSEQIRLGDDFNRELSR-RSRSDAETKRALEELTE-------KLN 208
D L H+ + +E RL N E+++ RS+ +A+ + EEL E +L
Sbjct: 1388 DCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQ 1447
Query: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268
EA++ ++ L++ + ++TE E V +L+L+ A A D+ +
Sbjct: 1448 EAEEGVEAANAKCSSLEKAKLRLQTESEDV----------TLELERATSAAAA-LDKKQR 1496
Query: 269 AIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH 328
++ L + ++ ++++ELE ++R L H EE L + + K LQ
Sbjct: 1497 HLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQE 1556
Query: 329 QVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSD------------LRVQLNFSA 376
++S ++ Q S E + ++ +E EK +++ + + LR+QL S
Sbjct: 1557 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 1616
Query: 377 MASELEEVKRCMERKDKEKAHLASQ----VENLTRELENGEKQQLQMLDRLKEIQNHFDT 432
+ +E++ R + KD+E A+L VE+L L+ + + + L RLK+
Sbjct: 1617 VKAEVD---RKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL-RLKK------K 1666
Query: 433 CEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQ 492
E + +LQ+ TR A +A ++L++ +A ++E ++ +L +AQ
Sbjct: 1667 MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA---- 1722
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
LER + ++EL Q + + + +L A +++ L + +L +
Sbjct: 1723 -------LERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQ 1775
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHL 612
+ E +L ++ + + + E + K ++ + ELKK+ + ++ K L
Sbjct: 1776 KKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTL 1835
Query: 613 EEEIAELK-KSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQ 671
E+ + EL+ + + ++A L ++ ++ L A +L +L E++ LK +
Sbjct: 1836 EQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGV------ 1889
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAEN 731
+ + + Q + +R + ++DL LQS +K +K++ EAE
Sbjct: 1890 -RKHERRVKELAYQAEEDRK-NLARMQDLVDKLQS-----------KVKSYKRQFEEAEQ 1936
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLK 781
T N+AK + Q E D E E + KL+ +
Sbjct: 1937 QANT---------NLAKYRKAQHE-----LDDAEERADMAETQANKLRAR 1972
Score = 80.5 bits (197), Expect = 8e-15
Identities = 145/679 (21%), Positives = 260/679 (38%), Gaps = 125/679 (18%)
Query: 21 AARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYR---EYSNGQAGAIE 77
A ST RG + E++ + + SR Q L R E + A+
Sbjct: 1320 ADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALA 1379
Query: 78 HLKESLEQSIDQLRSQ------------RLLRNSGGRSISVTSLSASDLDGGTGSELHHF 125
H ++L D LR Q RLL + S +D T EL
Sbjct: 1380 HAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRT-EELEEA 1438
Query: 126 PPTSPLKDYGDPQGIKRMRSRTG------VRFVQETDDMT-QLHGFHQSLRDLSSEQIRL 178
L+ +G++ ++ +R E++D+T +L + L +Q L
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 179 GDDFNRELSRRSRSDAETKRALEELTEKLN----EAQKQEVVSDRVERRLQELEREMRTE 234
R L R R + E +R LE + E + + L+ L+RE +
Sbjct: 1499 ----ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554
Query: 235 RELVERRQDQLGLMSLQLQEALKKQ----------EAKADEHEGAIKNKLRQTETEKNQL 284
+E + DQ+ L +QE K + +A +E EGA++ L +T+T + QL
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE--LEETKTLRIQL 1612
Query: 285 EQ---ELELSRRLLNQSE---GSRETLLHQVEELRTQLT--------------KAEGDRK 324
E + E+ R+L + E R VE L+ L K EGD
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1672
Query: 325 GLQHQVSQISKQ-----------QSNYQDEQG---EDWRFRRGVEREKQDLEKQMSDLRV 370
L+ Q+ ++Q Q+ ++EQ E+ R + + Q LE++ S
Sbjct: 1673 DLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRAS---- 1728
Query: 371 QLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQ--- 427
+A+ELEE++ +E+ ++ + ++ T L Q +L++ K+++
Sbjct: 1729 -----LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 428 ----NHFDTCEAERKHAD----------LQISELTRHAEDATKQAERYLSELQQS----E 469
+ ER+ A+ ++E + +D + ER L+Q+ +
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 470 ALKEEAE--------KRREDLKLKAQESIRQWKLKHKKLERALE---KQSETVDELTGKN 518
A EEAE K+ + L+ K +E + + KK AL+ K V EL +
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQA 1903
Query: 519 NQILKEK-------DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIK 571
+ K D+L++++ + +Q E ++ N L K + EL EE+ +
Sbjct: 1904 EEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAE 1963
Query: 572 SHQADLELEVKNSLDTIHR 590
+ L +++L H+
Sbjct: 1964 TQANKLRARTRDALGPKHK 1982
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 137 bits (346), Expect = 4e-32
Identities = 185/902 (20%), Positives = 389/902 (43%), Gaps = 97/902 (10%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRL 95
E+ EK+ +T ++D R + V+ + + + A + KE+L +L S++
Sbjct: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENL--GWQKLESEKA 1163
Query: 96 LRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRF---- 151
++ + + L + GT + Y + R + T +
Sbjct: 1164 IKE---KEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTT 1220
Query: 152 -----VQETDDM----TQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSD---AETKRA 199
+Q+ DD QL + RDL E +RL D + +R R++ + K
Sbjct: 1221 IKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAC 1280
Query: 200 LEELTEKLN--EAQKQEVVSDRVE---RRLQELEREMRTERELVERRQDQLGLMSLQLQE 254
E+ +K E + ++V+ R E R Q LE +T ++ + ++ + + QE
Sbjct: 1281 GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKT----IQDKNKEIERLKAEFQE 1336
Query: 255 ALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSR----RLLNQSEGSRETLLHQVE 310
K++ +E N + + KNQ E E+ +++ +L Q E Q++
Sbjct: 1337 EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQID 1396
Query: 311 ELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLE---KQMSD 367
L + + K L++ ++Q ++ +++ + V + KQ LE +Q++
Sbjct: 1397 NLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQ 1456
Query: 368 LRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQ 427
+R + + S L++ + ++ K+KE L ++ T + + E + ++ ++Q
Sbjct: 1457 MRTEESVRYKQS-LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQ 1515
Query: 428 NHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQ 487
+ +Q ELTR D E + +E + +D+ + Q
Sbjct: 1516 KANSSATETINKLKVQEQELTRLRID--------------YERVSQERTVKDQDI-TRFQ 1560
Query: 488 ESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELN 547
S+++ +L+ +K+E L + T E + K ++ +E + ++ L +I NL ++L
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 548 DVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELK--KQSKIQSQM 605
+ E++L + + L H E + + + + RL SE++ ++ +Q Q
Sbjct: 1621 QASIVKKRSEDDLRQQRDVL---DGHLR----EKQRTQEELRRLSSEVEALRRQLLQEQE 1673
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANK---LAEEERAKKAVL 662
V++AHL E +K+ L E + I+ L ++ +L + L EE R +
Sbjct: 1674 SVKQAHLRNE--HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEY 1731
Query: 663 KDLSDLTAQAKSRDEETATII---TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELM 719
DL ++A S ++ ATI+ +QL++ + EL+ L + LQ + +N+++ +
Sbjct: 1732 DDLRRGRSEADS--DKNATILELRSQLQISNN-RTLELQGLINDLQ----RERENLRQEI 1784
Query: 720 KHFKKEKSEAENHIRTLK---AESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN--- 773
+ F+K+ EA N I+ K + ++E+ + LE+ K++ RL +EL + ++
Sbjct: 1785 EKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLE 1844
Query: 774 ENKKLKLKYQCLKDQ----LEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILG 829
++K + +C K Q L + + S +EE +R++E R + + + L +E E +
Sbjct: 1845 AETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQA 1904
Query: 830 VIGKEIDAACKTFSKDS---------VEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEE 880
I K I+ C+ +DS E+ + + P+ E++T+ +W +
Sbjct: 1905 EI-KRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDT 1963
Query: 881 LK 882
K
Sbjct: 1964 SK 1965
Score = 135 bits (339), Expect = 3e-31
Identities = 163/814 (20%), Positives = 365/814 (44%), Gaps = 80/814 (9%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELE 228
R+ +E ++ + +N E+S R+ ET+ + + T K QK++ S + +L L
Sbjct: 1186 REYENELAKVRNHYNEEMSNL-RNKYETEINITKTTIKEISMQKEDD-SKNLRNQLDRLS 1243
Query: 229 REMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQEL 288
RE R ++ + R D + LQ E ++ E E A++ K +E + + E+
Sbjct: 1244 RENRDLKDEIVRLNDSI----LQATEQRRRAE------ENALQQKACGSEIMQKKQHLEI 1293
Query: 289 ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDW 348
EL + + +SE + E +T +Q + +I + ++ +Q+E W
Sbjct: 1294 ELKQVMQQRSEDNARHKQSLEEAAKT-----------IQDKNKEIERLKAEFQEEAKRRW 1342
Query: 349 RFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRE 408
+ + + + + ++++ L+ Q ++ + + +K+++ + +Q++NLTRE
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTT-IHQLTMQKEEDTSGYRAQIDNLTRE 1401
Query: 409 LENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS 468
+ + + +K ++N + + I + + +++ ++ EL+Q
Sbjct: 1402 NRS-------LSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
Query: 469 EALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL 528
++ E R + A ++I+ + ++L++ ++K++ L +N ++ + + +L
Sbjct: 1455 TQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDL 1514
Query: 529 KTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADL-ELEVKNSLDT 587
+ +A + I L+ + ++ R E + K +DI Q L EL+++
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ--- 1571
Query: 588 IHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADL 647
++E EL + + S+ ++ LEEE+ +++S + K+ + + ++ S ++
Sbjct: 1572 --KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRS 1629
Query: 648 ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV 707
+ L ++ +D+ D + K R +E + +L E + +R+L +SV
Sbjct: 1630 EDDLRQQ--------RDVLDGHLREKQRTQEE---LRRLSSEVEALRRQL---LQEQESV 1675
Query: 708 KTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
K H +N +HF+K + K+ SL E + ++E+L+S + LT+E
Sbjct: 1676 KQAHLRN-----EHFQKAIED--------KSRSLNESKI------EIERLQSLTENLTKE 1716
Query: 768 LTQNENENKKLKLKYQCLKDQLEERE--KHISIEE--EHLRRMEEARLQLKDQLLCLETE 823
E E + L+L+Y L+ E + K+ +I E L+ L+L+ + L+ E
Sbjct: 1717 HLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRE 1776
Query: 824 QESILGVIGKEIDAACKTFSK--DSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+E++ I K A + ++ +S + + + L + K +LQ L +EL
Sbjct: 1777 RENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL 1836
Query: 882 KERENR---EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLL 938
++ E ++ +L +QQ++N +++ + I + E ++ REK L
Sbjct: 1837 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1896
Query: 939 EETQRKDEEMGSLQDRV-IALETSTQVALDHLES 971
E +R E+ +++R LE ST+ LE+
Sbjct: 1897 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLET 1930
Score = 118 bits (296), Expect = 3e-26
Identities = 193/870 (22%), Positives = 366/870 (42%), Gaps = 143/870 (16%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQ------KQEV------- 215
RD +SE ++ L + ++ K L L E +A+ KQ +
Sbjct: 1045 RDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQI 1104
Query: 216 --VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK 273
+++++ R E+E E R R+ VE R DQ Q + + Q+A+ E E K
Sbjct: 1105 KELNEKITRLTYEIEDEKR-RRKSVEDRFDQ------QKNDYDQLQKARQCEKENLGWQK 1157
Query: 274 LRQTETEKNQLEQELELSR-RLLNQSEGSRETLL---------HQVEELRTQLTKAEGDR 323
L E+EK E+E E+ R R+L Q EG+R+ H EE+ K E +
Sbjct: 1158 L---ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 324 KGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEE 383
+ + +IS Q+ + D + + R + RE +DL+ ++ V+LN S + + E+
Sbjct: 1215 NITKTTIKEISMQKED--DSKNLRNQLDR-LSRENRDLKDEI----VRLNDSILQAT-EQ 1266
Query: 384 VKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQ 443
+R E ++KA S++ + LE KQ +Q R ++ H + E
Sbjct: 1267 RRRAEENALQQKA-CGSEIMQKKQHLEIELKQVMQQ--RSEDNARHKQSLE--------- 1314
Query: 444 ISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWK--------- 494
E + +D K+ ER +E Q+ + E E ++ E I K
Sbjct: 1315 --EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINI 1372
Query: 495 LKHKKLERALEKQSET------VDELTGKNNQILKEKDELKTQLYAALQQIENLRKELND 548
K + ++K+ +T +D LT +N + +E LK L Q ENLR+ D
Sbjct: 1373 TKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL---TQTTENLRRVEED 1429
Query: 549 VLTKRALQEEELHSKEE---KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+ ++A E K++ +LR + + + + K SLD + + K+ + Q+
Sbjct: 1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQL 1489
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+++E + +K + A+L +Q ++ ++ + NKL +E+
Sbjct: 1490 ------IDKETND-RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE-------- 1534
Query: 666 SDLTAQAKSRDEETATIITQLKL--ERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFK 723
+T+L++ ER +R +KD Q + T+ + +++EL +
Sbjct: 1535 -----------------LTRLRIDYERVSQERTVKD-----QDI-TRFQNSLKELQLQKQ 1571
Query: 724 KEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQ 783
K + E RT +S + K + + G LK Q ++T Q E + K
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
Query: 784 CLKDQLEEREKHISIEE---EHLRRMEEARLQLKDQLLCLETEQESILGV------IGKE 834
L+ Q + + H+ ++ E LRR+ L+ QLL EQES+ K
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLL---QEQESVKQAHLRNEHFQKA 1688
Query: 835 IDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKE-RENREKNLRH 893
I+ ++ ++ +E ++ S ++ + H L E L+ ++L+ R + +
Sbjct: 1689 IEDKSRSLNESKIEIERLQSLTENLTKE-HLMLEEELRNLRLEYDDLRRGRSEADSDKNA 1747
Query: 894 QLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQD 953
++ R QL+ ++ N+ ELQ L++++ RE+ +L +E ++ ++ +
Sbjct: 1748 TILELRSQLQ-ISNNRTLELQ----------GLINDLQRERENLRQEIEKFQKQALEASN 1796
Query: 954 RVIALETSTQVALDHLESVPEKLSLLEDFK 983
R+ + + ES+ K+ +LE K
Sbjct: 1797 RIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
Score = 87.8 bits (216), Expect = 5e-17
Identities = 112/530 (21%), Positives = 237/530 (44%), Gaps = 56/530 (10%)
Query: 164 FHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR 223
F SL++L ++ ++ ++ NR L R + D+ ++ LEE E + + K++ + ++
Sbjct: 1559 FQNSLKELQLQKQKVEEELNR-LKRTASEDSCKRKKLEEELEGMRRSLKEQAI--KITNL 1615
Query: 224 LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQ 283
Q+LE+ ++ + + Q ++ L+E + QE +LR+ +E
Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQE------------ELRRLSSEVEA 1663
Query: 284 LEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE 343
L ++L + + Q+ E +E+ L +++ + + LQ ++K+ ++E
Sbjct: 1664 LRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEE 1723
Query: 344 ----QGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMAS-ELEEVKRCMERKDKEKAHL 398
+ E RRG D + +LR QL S + EL+ + ++R
Sbjct: 1724 LRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQR-------- 1775
Query: 399 ASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQA 458
+ ENL +E+E +KQ L+ +R++E +N ER+ ++I L E +
Sbjct: 1776 --ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVL----EQDKARL 1829
Query: 459 ERYLSELQQSEALKE---EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELT 515
+R EL ++++ E ++R E K + Q + QWK ++ + E A+ K ++
Sbjct: 1830 QRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1889
Query: 516 GKNNQILKEKDELKTQLYAALQQI-ENLRKELNDVLTKRALQEEELHSKEE------KLR 568
+ N + E + L+ A +++I E R++L D + Q E S+ + + R
Sbjct: 1890 REKNSLRSEIERLQ----AEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
Query: 569 DIKSHQADLELEVKNSLDTIHRLESELKKQ---SKIQSQMKVEKAHLEEEIAELKKSQAQ 625
SH+ + + E + ++DT + L+K+ ++ ++K L +++ + KKS +
Sbjct: 1946 PYGSHR-ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTL-DKLLKGKKSVEE 2003
Query: 626 DKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSD---LTAQA 672
+++ ++ A K + E +K ++ S L AQA
Sbjct: 2004 VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQA 2053
Score = 67.0 bits (162), Expect = 9e-11
Identities = 142/686 (20%), Positives = 271/686 (39%), Gaps = 105/686 (15%)
Query: 370 VQLNFSAMASELEEVKRCME--RKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQ 427
VQ + A+A L ++K + R ++ +L ++V L ++LEN L+ L ++
Sbjct: 712 VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
Query: 428 NHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLK-- 485
A LQ ++ + E + E +L + EA + +K + DL LK
Sbjct: 772 ALLQ--------AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKS 823
Query: 486 -----------AQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYA 534
AQ+ Q ++ + L K E V +LT + +I K+ D L
Sbjct: 824 LLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEK 883
Query: 535 ALQQIENLR-------KELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDT 587
++Q+ N R K L D ++ E + + Q +L E+ D
Sbjct: 884 QIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK 943
Query: 588 IHRLE--SELKKQS--KIQSQMKVEKAHLEEEI-AELKKSQAQDKAKLLEMQESIKDLSA 642
++ +EL S + Q+ + LE + +K++ Q + ++ +QE+ D+ A
Sbjct: 944 SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVI-LQEAA-DVHA 1001
Query: 643 IRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQREL---KD 699
+L + + R +LK L DL K ++ + + +L+L RD + K
Sbjct: 1002 RYIELLTRSGDYYRFLSEMLKSLEDL----KLKNTKIEVLEEELRLARDANSENCNKNKF 1057
Query: 700 LTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKS 759
L +LQ + + Q FK + + E R + + K GQ+++L
Sbjct: 1058 LDQNLQKYQAECSQ--------FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
Query: 760 QCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRME-EARLQLKDQLL 818
+ RLT E+ + K ++ ++ K+ ++ +K E+E+L + E+ +K++
Sbjct: 1110 KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEK-- 1167
Query: 819 CLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLC 878
E E E + ++ +E K ++ + K++ HY+
Sbjct: 1168 --EYEIERLRVLLQEE--GTRKREYENELAKVR-------NHYN---------------- 1200
Query: 879 EELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIER----QEQLLDEIHREK 934
+E N ++ + + ++ ++ KE + + L Q++R L DEI R
Sbjct: 1201 ---EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLN 1257
Query: 935 RDLLEET-QRKDEEMGSLQDRVIALETSTQVALDHLE-------------SVPEKLSLLE 980
+L+ T QR+ E +LQ + E + HLE + K SL E
Sbjct: 1258 DSILQATEQRRRAEENALQQKACGSEIMQK--KQHLEIELKQVMQQRSEDNARHKQSLEE 1315
Query: 981 DFKDFRDSCSSSERTDGRYSKYRVRR 1006
K +D ER + + RR
Sbjct: 1316 AAKTIQDKNKEIERLKAEFQEEAKRR 1341
Score = 33.5 bits (75), Expect = 1.1
Identities = 68/369 (18%), Positives = 144/369 (39%), Gaps = 29/369 (7%)
Query: 175 QIRLGDDFNRELSRR-SRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRT 233
+++ GD SR A+ +E L + E ++ D ++RL +L+ +MR
Sbjct: 92 ELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA 151
Query: 234 ERELVE----RRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELE 289
+ + RR G Q E + +RQ E + + ++
Sbjct: 152 LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECL-GWMRQQRAEMDMVAWGVD 210
Query: 290 LSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWR 349
L+ + Q S + + + + R QL K + D + + + Q+ ++ N E
Sbjct: 211 LAS--VEQHINSHRGIHNSIGDYRWQLDKIKADLRE-KSAIYQLEEEYENLLKASFERMD 267
Query: 350 FRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTREL 409
R ++ Q +++ + + + + + +K + + SQ+E +EL
Sbjct: 268 HLRQLQNIIQATSREIMWIN-DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKEL 326
Query: 410 ENGEKQQLQML----DRLKEIQNHFDTCEAE-------RKHADLQISELTRHAE--DATK 456
+++ Q++ +I+ + DT + + K D+ + E + + + +
Sbjct: 327 NKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQ 386
Query: 457 QAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTG 516
E YL LQ S K +K + Q + Q K K+ E+ LE + + V L
Sbjct: 387 STEAYLKGLQDSIRKKYPCDK-----NMPLQHLLEQIKELEKEREKILEYKRQ-VQNLVN 440
Query: 517 KNNQILKEK 525
K+ +I++ K
Sbjct: 441 KSKKIVQLK 449
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 137 bits (345), Expect = 6e-32
Identities = 195/902 (21%), Positives = 380/902 (42%), Gaps = 114/902 (12%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
Q LRD + ++ +D RE+ R ++ R L L AQ+Q + +LQ
Sbjct: 571 QRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQ 630
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLE 285
+ E+R +R+ +E Q+ +++ L++ +L Q E +++ L
Sbjct: 631 AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH-----------RQLEQLEGKRSVLA 679
Query: 286 QELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQG 345
+EL R L+++ R+ L + E+ LTKAE R L+ ++++ ++++ QD
Sbjct: 680 KELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLS 739
Query: 346 EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENL 405
+ + ++K DL + + ++LEE K ++ + ++ A Q +
Sbjct: 740 KLSALNESLAQDKLDLNR-------------LVAQLEEEKSALQGRQRQ----AEQEATV 782
Query: 406 TRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
RE + +RL+E++ E++ A + R AE A + E
Sbjct: 783 AREEQ----------ERLEELR-------LEQEVARQGLEGSLRVAEQAQEALE------ 819
Query: 466 QQSEALKEEAEKRREDL-KLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKE 524
QQ L+ E + +E L +L Q S R+ +L+ + R ++Q E ++ + + KE
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR--REAQRQVEALERAAREKEALAKE 877
Query: 525 KDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNS 584
L QL AA ++ L +E + ++ E L + +L +++ + LE E +
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL 937
Query: 585 LDTIHRLESELK--KQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSA 642
L L EL +Q I +Q EKA L++E+ K QA+ +A Q S+++ A
Sbjct: 938 LLAKETLTGELAGLRQQIIATQ---EKASLDKELMAQKLVQAEREA-----QASLREQRA 989
Query: 643 IRADLANKLAEEERAKKAVLKDLSDLTAQAKSR-DEETATIITQLKLERDVHQRELKDLT 701
+ +L +R K+A ++L AQ +S+ E ++ +L+ E++ E+ L
Sbjct: 990 AHEEDLQRL---QREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQ 1046
Query: 702 SSLQSVKTKHEQNIQELMKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKL 757
E Q+ + + EK+ + +L SLE + + + + E+
Sbjct: 1047 QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQD 1106
Query: 758 KSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEH-LRRMEEARLQLKDQ 816
+S + LT EL + ++ + +L+E+ + + + + LR EE R QL+
Sbjct: 1107 RSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLR-- 1164
Query: 817 LLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWL---AESKTK 873
LE ++ G+ + ++A K +++ +G + R L A+ +
Sbjct: 1165 --LLEDARD---GLRRELLEAQRKLRESQEGREVQRQEAG-----ELRRSLGEGAKEREA 1214
Query: 874 LQWLCEELKERENREKNLRHQLMLCR----------QQLRNLTENKESELQCLFQQIERQ 923
L+ EEL+ + ++ R L L ++ R + EL+ Q++ER
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
Query: 924 ----EQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLL 979
+ L E+ R+ + L E R E+ LQ R+ E + + ES E L L
Sbjct: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK------ESRRETLGLR 1328
Query: 980 EDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTRGLD 1039
+ S + + +V + LQ + + + R + G G+ + LD
Sbjct: 1329 QRLLKGEASLEVMRQ------ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
Query: 1040 HS 1041
H+
Sbjct: 1383 HA 1384
Score = 116 bits (291), Expect = 1e-25
Identities = 213/1003 (21%), Positives = 409/1003 (40%), Gaps = 169/1003 (16%)
Query: 169 RDLSSEQIRLGDDFNRELSRR-SRSDAETKRALEELTEK---------LNEAQKQEVVSD 218
R+L +E+ +L RE +R +AE + EE+ L E++KQ+ +S
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS- 1065
Query: 219 RVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG---AIKNKLR 275
L+E E+ +E+ + R L +SL+++ + +++ ++ A+ ++LR
Sbjct: 1066 -----LKESEKTALSEKLMGTRHS--LATISLEMERQKRDAQSRQEQDRSTVNALTSELR 1118
Query: 276 QTETEKNQLEQ-ELELSRRLLNQSEG---SRETLLHQVEELRTQLTKAEGDRKGLQHQVS 331
++ + + RRL Q+ R++ L + EELRTQL E R GL+ ++
Sbjct: 1119 DLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELL 1178
Query: 332 QISKQQSNYQD-------EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEV 384
+ ++ Q+ E GE R +E++ L + +LR + +E E +
Sbjct: 1179 EAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK----KAESERI 1234
Query: 385 KRCMERKDKE---------KAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEA 435
+ +DKE + + + L L+ E+ +L+ L+E++ ++
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294
Query: 436 ERKHADLQISELTRH---AEDATKQAERYLSELQQSEALKEEA--EKRREDLKL---KAQ 487
E +++EL E A K++ R L+Q LK EA E R++L++ K Q
Sbjct: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQ-RLLKGEASLEVMRQELQVAQRKLQ 1353
Query: 488 ESIRQWKLKHKKLERALEK----QSETVDELTG---KNNQILKEKDELKTQLYAALQQIE 540
E +++ + ++L +LE+ + + +D G K E EL +L AA + +
Sbjct: 1354 EQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQ 1413
Query: 541 NLRKELNDVLTKRALQEEELHSKEEKLR-------------------DIKSHQADLELEV 581
L EL V +R E +L LR + A+ E
Sbjct: 1414 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
Query: 582 KNSLDTIH-------------------RLESELKKQSKIQSQMKVEKAHLEEEIAELKKS 622
NS T+ L+ E + + + ++ A E + EL+
Sbjct: 1474 LNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERD--ELRTQ 1531
Query: 623 QAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQA--------KS 674
+ +L EM+ ++ L +AE E A+++V LS + A+ +S
Sbjct: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591
Query: 675 RDEETATIITQLKLERDVHQRELK-----DLTSSLQSVKTKHE---QNIQELMKHFKKEK 726
E AT+ LER + E + + S +++ +TK E + ++E++ +
Sbjct: 1592 ERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT 1651
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
+ E R+L+ E + Q + L+ + D L ++ +E + L+L + L
Sbjct: 1652 VKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLN 1711
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQ-------LKDQLLCLE---TEQESILGVIGKEID 836
L + E+ + +R + EA Q +D+ L L+ T E V+ + +D
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
Query: 837 AACKTFSKDSVEKLKVFSSGPDIH---YDPHRWLAESKTKLQWLCEELKERENRE----- 888
AA + S+ + + + D E++ +LQ L E L++R+ E
Sbjct: 1772 AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN 1831
Query: 889 --KNLRHQLMLCRQQLRNL--------TENKESELQCLFQQIERQ--EQLLDEIHREKRD 936
+ L+ + L +++L +L E +E E L + +R + LD++ REK
Sbjct: 1832 TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLR 1891
Query: 937 LLEETQRKDEEMG---------------------SLQDRVIALETSTQVALDHLESVPEK 975
E+T R E G L+ +V+ LE S A +++ ++
Sbjct: 1892 SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
Query: 976 LSLLEDFKDFRDSCSSSERT-DGRYSKYRVRRNSLQHHQDDTK 1017
L L ++ + R + + +ERT + R +R R L+ K
Sbjct: 1952 LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
Score = 113 bits (283), Expect = 9e-25
Identities = 152/690 (22%), Positives = 294/690 (42%), Gaps = 62/690 (8%)
Query: 158 MTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVS 217
MT+L SL+D S+ L + ++ +R A+ + L + +A+++ V+
Sbjct: 724 MTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
Query: 218 DRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQT 277
+ RL+EL R E+E+ + + ++ Q QEAL++Q ++ +L Q
Sbjct: 784 REEQERLEEL----RLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 278 ETEKNQLEQELELSRR-------LLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQV 330
+ + EQELE +RR L ++ +E L + L QL AE + + L +
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 331 SQISKQQSNYQDEQGEDWRFRRGVE--REKQDLEKQMSDLRVQLNFSAMASELEEVKRCM 388
+++ ++ + E R +E RE+ + E Q L + +A +++
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 959
Query: 389 ERKDKEKAHLASQVENLTRELENGEKQQ-------LQMLDRLKEIQNHFDTCEAERKHAD 441
E+ +K +A ++ RE + ++Q LQ L R KE E E + A
Sbjct: 960 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWR----ELEAERAQ 1015
Query: 442 LQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE 501
LQ S+L R E+ + E EL SE + ++R E L L E + LK +
Sbjct: 1016 LQ-SQLQREQEELLARLEAEKEEL--SEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072
Query: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH 561
EK T L + ++ ++K + +++ + L EL D+ RA +EE
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL---RAQREEAAA 1129
Query: 562 SKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKK 621
+ +++R ++ DL + +S L++ ++++Q+++ LE+ L++
Sbjct: 1130 AHAQEVRRLQEQARDLG----------KQRDSCLREAEELRTQLRL----LEDARDGLRR 1175
Query: 622 SQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETAT 681
+ + KL E QE + +L L E + ++A+ + +L + K + E +
Sbjct: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
Query: 682 I----------ITQLKLERDVHQRELKDLTSSLQSV---KTKHEQNIQELMKHFKKEKSE 728
+ + L+ R +E +L + LQ V + + + +QEL + K SE
Sbjct: 1236 LKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
Query: 729 AENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQ 788
L E E + + ++ + + L + L + E + ++ + Q + +
Sbjct: 1296 NTR----LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK 1351
Query: 789 LEEREKHISIEEEH-LRRMEEARLQLKDQL 817
L+E+E E L +EEAR K QL
Sbjct: 1352 LQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
Score = 106 bits (265), Expect = 1e-22
Identities = 190/888 (21%), Positives = 370/888 (41%), Gaps = 160/888 (18%)
Query: 192 SDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--RRQDQLGLMS 249
+++ + ALE+ + L +AQ +E + D+V R +++M+++ + + R +LGL
Sbjct: 349 AESRAEAALEK--QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 406
Query: 250 LQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQV 309
+L+ KQ + D+ + KL E+ + Q + LE EG ++TL
Sbjct: 407 KRLE----KQNLEKDQVNKDLTEKLEALESLRLQEQAALETE-----DGEGLQQTLRDLA 457
Query: 310 E------ELRTQLTKAE-------GDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E QL+ +E G +GL Q + ++S+ G RRG
Sbjct: 458 QAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSS----PGRGRSPRRGPSP 513
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQ--VENLTRELENGEK 414
D + L SA+ KR ++ +D + ASQ + L ++L + E
Sbjct: 514 ACSDSST------LALIHSALH------KRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561
Query: 415 QQLQMLDRLKEIQNHFDTCEAERKHADLQI--------------SELTRHAEDATKQAER 460
++ + ++L+ +++ D + A ++ S L + A +QAE
Sbjct: 562 ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621
Query: 461 YLSELQQSEALKEEAEKRREDLKLKAQESI-------RQWKLKHKKLERALEKQSETVDE 513
E ++ +A +EE ++R+ L+ + ++++ R+ + H++LE+ K+S E
Sbjct: 622 LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKE 681
Query: 514 LTGKNNQILK---EKDEL---KTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKL 567
L + + ++D L K ++ AL + E R EL +TK +E L KL
Sbjct: 682 LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKL 741
Query: 568 RDIKSHQADLELEVKNSLDTIHRLESELKKQSK---------IQSQMKVEKAHLEEEIAE 618
+ A +L++ + + +S L+ + + + Q ++E+ LE+E+A
Sbjct: 742 SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
Query: 619 L-------------------------KKSQAQDKAKLLEMQES--IKDLSAIRADLANKL 651
++SQ Q++ L Q S ++L R + ++
Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
Query: 652 AEEERA---KKAVLKDLSDLTAQAKSRDEETATI---ITQLKLERDVHQRELKDLTSSLQ 705
ERA K+A+ K+ + L Q + + E T+ T+L+LE++ + L ++ L
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
Query: 706 SVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESL--EEKNMAKIHRGQLEKLKSQCDR 763
++ + EQ EAE L E+L E + + EK +
Sbjct: 922 QLEARREQ-------------LEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL 968
Query: 764 LTEELTQNENE-NKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLET 822
+ ++L Q E E L+ + ++ L+ ++ +E R +E R QL+ Q L+
Sbjct: 969 MAQKLVQAEREAQASLREQRAAHEEDLQRLQRE---KEAAWRELEAERAQLQSQ---LQR 1022
Query: 823 EQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELK 882
EQE +L + E + + + E+ D LAES+ + + L
Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQER------------DEGLLLAESEKQ-----QALS 1065
Query: 883 ERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQ 942
+E+ + L +LM R L ++ E + + + E+ ++ + E RDL Q
Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL--RAQ 1123
Query: 943 RKD------EEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKD 984
R++ +E+ LQ++ L L E + +L LLED +D
Sbjct: 1124 REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171
Score = 98.2 bits (243), Expect = 4e-20
Identities = 178/878 (20%), Positives = 354/878 (40%), Gaps = 123/878 (14%)
Query: 41 VNTITSTLQDTS--------------RNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQS 86
VN +TS L+D R L++ + LG+ R+ +A + LE +
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
Query: 87 IDQLR-----SQRLLRNSG-GRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDP--Q 138
D LR +QR LR S GR + G G++ L+ +
Sbjct: 1170 RDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK-----EREALRRSNEELRS 1224
Query: 139 GIKRMRS-RTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDD---FNRELSRRSRSDA 194
+K+ S R ++ E + Q L L + +G + L RS
Sbjct: 1225 AVKKAESERISLKLANEDKE--------QKLALLEEARTAVGKEAGELRTGLQEVERSRL 1276
Query: 195 ETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRT-ERELVERRQDQLGLM----- 248
E +R L+EL ++ + R+ R L EL+ + ER E R++ LGL
Sbjct: 1277 EARRELQELRRQMKMLDSENT---RLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
Query: 249 ---SLQ-LQEALKKQEAKADEHEGAIKNKLRQT----ETEKNQLEQELELSRRLLNQSEG 300
SL+ +++ L+ + K E EG + + R+ E + +Q+L+ +R L + E
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEA 1393
Query: 301 SRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQG---EDWRFRRGVERE 357
+R + EL +L+ AEG +GL+ +++++ Q+ + + G R G+ R
Sbjct: 1394 ARA----EAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRA 1449
Query: 358 KQDLEKQMSDLRVQLNFSAMASELEEVKRCME-----------------RKDKEKAHLAS 400
+ + + + + E +E D + +
Sbjct: 1450 PSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRG 1509
Query: 401 QVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTR---HAEDATKQ 457
+ +EL + ++++ ++ + + EAER A + +L + +E+A +
Sbjct: 1510 ALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS 1569
Query: 458 AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGK 517
+ LS +Q AL+EE+ +R E + + + + + E L E + ++
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
Query: 518 NNQILKEKDELKTQLYAA---LQQIENLRKELNDVLTKRAL----QEEELHSKEEKLRDI 570
++ +K LK L A+ ++E R+ L L + L +E + + ++++ +
Sbjct: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSL 1689
Query: 571 KSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKL 630
+ AD E++ T+ RL L K + + ++ + L E +A+ S + K
Sbjct: 1690 QRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKN 1749
Query: 631 LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIIT------ 684
L +Q+++ R L +L +A K S L Q ++ E A +
Sbjct: 1750 LHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809
Query: 685 -QLKLERDVHQRELKDLTSSLQSVKTKHEQ---------NIQELMKHFKKEKSEAENHIR 734
QL+ R+V ++ + ++L +V+ ++ ++Q + + EK E E
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
Query: 735 TLKAESLE-EKNMAKIHRGQLE------KLKSQCDRLTEELTQNENENKKLKLKYQCLKD 787
L+ + + + + K+ R +L +L ++ RL LT E E + + + Q L+
Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929
Query: 788 QLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQE 825
Q+ + +E+ H A+L++ Q LE +QE
Sbjct: 1930 QV------VVLEQSH----SPAQLEVDAQQQQLELQQE 1957
Score = 90.9 bits (224), Expect = 6e-18
Identities = 123/520 (23%), Positives = 228/520 (43%), Gaps = 63/520 (12%)
Query: 193 DAETKR-ALEELTEKLNEAQKQEVVSDRVERRLQELER---EMRTERELVERRQDQLGLM 248
D E R AL E ++L AQ++ D + + L R EM ER+ R QL
Sbjct: 1503 DPEAVRGALREFLQELRSAQRER---DELRTQTSALNRQLAEMEAERDSATSRARQLQKA 1559
Query: 249 SLQLQEALKKQEAKADEHEGAI---KNKLRQTETEKNQLEQELELSRRLLNQSEGSRETL 305
+ +EA + + + + + + +R++E E+ ++ R L +E
Sbjct: 1560 VAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRAS 1619
Query: 306 LHQVEELRTQLTKAEGDRKGLQHQV----SQISKQQSNYQDEQGEDWRFRRGV-EREKQ- 359
++ +++ TK EGD++ L+ + S+ K + + +GE R R G+ +RE Q
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQA 1679
Query: 360 --------DLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELEN 411
L++Q++D V+ + +E + + + ++ + L +V LT L
Sbjct: 1680 QALQDRVDSLQRQVADSEVKAG--TLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQ 1737
Query: 412 GEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL-QQSEA 470
D+ +Q CE +R ++ + DA +QA LSE +QS +
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDR--------QVLQERLDAARQA---LSEARKQSSS 1786
Query: 471 LKEEAEKRR---EDLKLKAQESIRQWKLKHKKLERALEKQS---ETVDELTGKNNQILKE 524
L E+ + R DL+L+ E+ Q + + L + E ++ TV +L + + +
Sbjct: 1787 LGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQER 1846
Query: 525 KDELK---TQLYAALQQIEN--LRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLEL 579
L+ QL A +++E LR E + V +R L + E EKLR SH+ + L
Sbjct: 1847 LGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE----REKLR---SHEDTVRL 1899
Query: 580 EV-KNSLD-TIHRLESELKKQSKIQSQMKVEKAHLEE--EIAELKKSQAQDKAKLLEMQE 635
K LD T+ E EL + + Q++ + LE+ A+L+ Q + LE+Q+
Sbjct: 1900 SAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ---LELQQ 1956
Query: 636 SIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
++ L + +A L ERA + ++ L + + K +
Sbjct: 1957 EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQ 1996
Score = 87.4 bits (215), Expect = 7e-17
Identities = 171/838 (20%), Positives = 332/838 (39%), Gaps = 157/838 (18%)
Query: 243 DQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELE-LSRRL---LNQS 298
+ L+SLQ + L +QE +++ L Q+ E+++L + +S RL L
Sbjct: 72 EMASLLSLQEENQLLQQELSR------VEDLLAQSRAERDELAIKYNAVSERLEQALRLE 125
Query: 299 EGSRET-----LLHQVEELRTQLTKAEGD-RKGLQHQVSQISKQQSNYQDEQGEDWRFRR 352
G ET L+ Q ELR QL + + R+ LQ +Q Q QG+ ++++
Sbjct: 126 PGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKK 185
Query: 353 GVEREKQDLEKQMSDLRVQ-LNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELEN 411
+Q L ++ +L Q L + + +LE +E + + A LA L +L+
Sbjct: 186 RCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQ 245
Query: 412 GEKQQLQMLDRLKEIQNHFDTCEAERKHAD------------------------------ 441
+ + ++++ N + C E +H +
Sbjct: 246 AGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305
Query: 442 ----------------LQISELTRHAEDATKQAERYLSE-LQQSEALKEEAEKRREDLKL 484
LQ+ A ++A LS L+ +E+ E A +++ L+
Sbjct: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQA 365
Query: 485 KAQESIRQWKLKHK-----KLERALEKQ--SETVDELTGKNNQILK---EKDELKTQLYA 534
+ +E +R L+ K +++ L+K S V EL ++ K EKD++ L
Sbjct: 366 QLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE 425
Query: 535 ALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKS---HQADLELEVKNSLDTIHRL 591
L+ +E+LR + + AL+ E+ ++ LRD+ ++ +++ S T
Sbjct: 426 KLEALESLRLQ-----EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
Query: 592 ESELKKQSKIQSQMKVEKAH----------------------LEEEIAELKKSQAQDKAK 629
L+ S ++ ++ L ++ Q QD
Sbjct: 481 NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540
Query: 630 LLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLE 689
E + + L +R L++ E RA + L+ L D T A E+ + +L+
Sbjct: 541 RYEASQDL--LGTLRKQLSDS-ESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA 597
Query: 690 RDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEE------ 743
++ RE +L SLQ + + E+ QE +EK +A + + LEE
Sbjct: 598 NELLSREKSNLAHSLQVAQQQAEELRQE------REKLQAAQEELRRQRDRLEEEQEDAV 651
Query: 744 -------KNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHI 796
+ + + HR QLE+L+ + L +EL + + L+ +D L+ + +
Sbjct: 652 QDGARVRRELERSHR-QLEQLEGKRSVLAKELVEVREALSRATLQ----RDMLQAEKAEV 706
Query: 797 SIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSG 856
+ E L + E R++L+ + L E+ S+ + K + A ++ ++D ++ ++ +
Sbjct: 707 A---EALTKAEAGRVELELSMTKLRAEEASLQDSLSK-LSALNESLAQDKLDLNRLVAQ- 761
Query: 857 PDIHYDPHRWLAESKTKLQWLCEE-------LKERENREKNLRHQLMLCRQQLRNLTENK 909
L E K+ LQ + +E + R + LR + + RQ L
Sbjct: 762 ----------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
Query: 910 ESELQCLFQQI----ERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQ 963
E + L QQ+ + QL +++ + R L Q ++ Q +V ALE + +
Sbjct: 812 EQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAR 869
Score = 84.0 bits (206), Expect = 7e-16
Identities = 183/895 (20%), Positives = 361/895 (40%), Gaps = 139/895 (15%)
Query: 185 ELSRRSRSDAETKRALEE--LTEKLNEAQKQEVVSDRVERRLQELEREMRT--------E 234
E R+ S+ T+ LE+ L L E Q+Q ++E R ++LE E +
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLA---QLEARREQLEAEGQALLLAKETLT 945
Query: 235 RELVERRQDQLG----------LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQL 284
EL RQ + LM+ +L +A ++ +A E A + L++ + EK
Sbjct: 946 GELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005
Query: 285 EQELELSR-RLLNQSEGSRETLLHQVE----ELRTQLTKAEGDR-KGL------QHQVSQ 332
+ELE R +L +Q + +E LL ++E EL ++ + +R +GL + Q
Sbjct: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
Query: 333 ISKQQSNYQDEQGEDWRFRRG-----VEREKQDLEKQMSDLRVQLNFSAMASELEEVKRC 387
+ + + E+ R +ER+K+D + + R +N A+ SEL +++
Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN--ALTSELRDLRA- 1122
Query: 388 MERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISEL 447
+R++ AH A +V L + + KQ+ L +E++ E R ++ E
Sbjct: 1123 -QREEAAAAH-AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA 1180
Query: 448 TRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQE---SIRQWKLKHKKLERAL 504
R ++ + E E + E K RE L+ +E ++++ + + L+ A
Sbjct: 1181 QRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLAN 1240
Query: 505 EKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKE 564
E + + + L + KE EL+T LQ++E R E L + Q + L S+
Sbjct: 1241 EDKEQKLALLEEARTAVGKEAGELRT----GLQEVERSRLEARRELQELRRQMKMLDSEN 1296
Query: 565 EKL-RDIKSHQADLEL----EVKNSLDTIHRLESELKKQSKIQ---SQMKVEKAHLEEEI 616
+L R++ Q L L E ++ +T+ + LK ++ ++ +++V + L+E+
Sbjct: 1297 TRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
Query: 617 AELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRD 676
E + + +LL E + + D A L + A +A +L + A+ R
Sbjct: 1357 GEFRTRE----RRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRA 1412
Query: 677 EETATIITQLKLERDVHQRELKDLTSSLQ-------------------------SVKTKH 711
+ + +++++R + +L L S+L+ + +
Sbjct: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
Query: 712 EQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKS----------QC 761
N ++ + + + + L+ + + R L++L+S Q
Sbjct: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQT 1532
Query: 762 DRLTEELTQNENENKKLKLKYQCLKDQLEEREK--------------HISIEEEHLRRME 807
L +L + E E + + L+ + E E+ ++++EE +RR E
Sbjct: 1533 SALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSE 1592
Query: 808 EARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWL 867
R DQ+ LE L E+ A+ + SK + K L
Sbjct: 1593 RERRATLDQVATLERS----LQATESELRASQEKISKMKANETK---------------L 1633
Query: 868 AESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIER-QEQL 926
K +L+ + + + R + + R L Q+ R ++E++ Q L +++ Q Q+
Sbjct: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
Query: 927 LD-EIHREKRDLLEE-----TQRKDEEMGSLQDRVIALETSTQVALDHLESVPEK 975
D E+ L E + +E G+L+D+V L + + L S +K
Sbjct: 1694 ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/138 (25%), Positives = 61/138 (44%), Gaps = 1/138 (0%)
Query: 166 QSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQ 225
++L + E++R +D R + + R D A EL E + Q+ E +E+
Sbjct: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHS 1939
Query: 226 ELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLE 285
+ E+ +++ +E +Q+ L S Q Q + EA+ H ++ Q T K QL+
Sbjct: 1940 PAQLEVDAQQQQLELQQEVERLRSAQAQTE-RTLEARERAHRQRVRGLEEQVSTLKGQLQ 1998
Query: 286 QELELSRRLLNQSEGSRE 303
QEL S + G E
Sbjct: 1999 QELRRSSAPFSPPSGPPE 2016
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 137 bits (344), Expect = 7e-32
Identities = 200/942 (21%), Positives = 388/942 (41%), Gaps = 121/942 (12%)
Query: 159 TQLHGFHQSLRDLSS-----EQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQ 213
++L H+++ L S E R+ REL + ++ + + +E L + EA+ Q
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ--VEHLQAAVVEARAQ 1370
Query: 214 EVVSDRVERRLQELE-------REMRTERELVERRQDQLGLMSLQ----------LQEAL 256
+ +E L+ E+ +ERE + Q+Q L Q L + L
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTL 1430
Query: 257 KKQEAKADEHEGAIKNKLRQTETEKNQLE----------QELELSRRLLNQSEGSRETLL 306
++E + + G I+ +Q E +K LE QE++L + + + E R L
Sbjct: 1431 AEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE 1490
Query: 307 H--------------QVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRR 352
H Q E++R E R L+HQ+ ++ K+ + ++G+
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQ------ 1544
Query: 353 GVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVE-------NL 405
QDL+KQ+ L +A ELEE ME + K L Q E +L
Sbjct: 1545 -----VQDLKKQLVTLE------CLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
Query: 406 TRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
T +LE ++ ++ ++++H E + D ++ E+ +Q E +L
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEK 525
++ + +E ++E +++ + RQ K+ + LE+ E ELT + + +
Sbjct: 1654 ERRD---QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
+E K A +E+++ L D + Q+E +H +E ++ L +V +
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 586 DTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRA 645
+ + E E+ + Q ++++A + E+ E D+A+ Q ++L A++
Sbjct: 1771 LLLSQREQEI-----VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD-QELEALQQ 1824
Query: 646 DLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQ 705
+ +EER +K+ +D A E+ + + E H+ + + L L
Sbjct: 1825 EQQQAQGQEER-----VKEKADALQGAL---EQAHMTLKERHGELQDHKEQARRLEEEL- 1875
Query: 706 SVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLT 765
+V+ + Q ++E++ + E E E + L+ + E+ A+ H + L+ +
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ---AQEHEVETRALQDSWLQAQ 1932
Query: 766 EELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQE 825
L + + E + L+ + Q + Q E +E L + A LQ K+Q L + E
Sbjct: 1933 AVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA-LQGKEQHLLEQAELS 1991
Query: 826 SILGVIGKEIDA---ACKTFSKDSVEKLKVFSS---GPDIHYDPHRWLAESKTKLQWLCE 879
L + A AC+ S+ E L++ D+ Y + + + L E
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED--VQQLQQALAQRDE 2049
Query: 880 ELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLE 939
EL+ ++ RE+ L L + + EN E Q L Q ER+E+ + +H+ R+L
Sbjct: 2050 ELRHQQEREQLLEKSLA------QRVQENMIQEKQNLGQ--EREEEEIRGLHQSVRELQL 2101
Query: 940 ETQRKDEEMGSLQDRVIALETSTQVALDH------LESVPEKLSLLED--FKDFRDSCSS 991
+K++E+ L++ + + AL H +E KL LE ++ ++
Sbjct: 2102 TLAQKEQEILELRE---TQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAA 2158
Query: 992 SERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGS 1033
+T+ R ++R + L TK S + FL+ S
Sbjct: 2159 LRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200
Score = 125 bits (315), Expect = 2e-28
Identities = 180/776 (23%), Positives = 349/776 (44%), Gaps = 94/776 (12%)
Query: 225 QELEREMRTERELVERRQDQLGLMSLQL---QEA---LKKQEAKADEHEGAIKNKLRQTE 278
Q+ ++ + R ++ RR+ + + QL QEA L++Q + +E A++ +L++
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 279 TEKNQLE-QELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQ 337
E++ L Q ++L + + S+ RE L EELR QL E + L+ ++ Q
Sbjct: 442 GERDTLAGQTVDLQGEVDSLSK-ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
Query: 338 SNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAH 397
+ Q ++ E RE++ L++ + L + + S SEL ++ +E E
Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL--SELITLREALESSHLEGEL 558
Query: 398 LASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRH-AEDATK 456
L + +T L E Q + L +N T A+ + A +++S L A D
Sbjct: 559 LRQEQTEVTAALARAE----QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 457 QAERYLSELQQSEAL---KEEAEKRREDLKLKAQESIRQ----WKLKHKKLERALEKQSE 509
++ L ++++++ E AE+ R L++ E+ ++ W+ K+ LE L+K E
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTHLEAQLQKAEE 673
Query: 510 TVDELTGKNNQILKEKDELKTQL-------YAALQQIENLRKEL--NDVLTKRALQEEEL 560
EL I +EK+E++ +L AA Q+E L +E + + RA+QE+E
Sbjct: 674 AGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733
Query: 561 HSKEE-----KLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+E+ +L+ ++ + DL +++ LES L + + S ++V K LE +
Sbjct: 734 LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 616 IAELKKS----QAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQ 671
I + ++ Q + + LE+ R A +LA+ E+ K L+ Q
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ------Q 847
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQE-------LMKHFKK 724
+ ++E + + + ER HQ+EL SL+ K + E ++E + ++
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907
Query: 725 EKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQ- 783
E+++AE+ + ++ E+ EK + L+ K D +++L + + K KLK Q
Sbjct: 908 ERTQAESALCQMQLET--EKERVSLLETLLQTQKELAD-ASQQLERLRQDMKVQKLKEQE 964
Query: 784 ---CLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILG---VIGKEI-D 836
L+ QL+E + R ++EA Q +D L L+ E S+L + K++ D
Sbjct: 965 TTGILQTQLQEAQ----------RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 837 AACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESK--TKLQWLCEELKERENREKNLRHQ 894
+ ++D ++L + + L E++ ++Q KE E + +L
Sbjct: 1015 LKSQLVAQDDSQRL--------VEQEVQEKLRETQEYNRIQ------KELEREKASLTLS 1060
Query: 895 LMLCRQQLRNLTEN---KESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEE 947
LM Q+L L E ++ EL L Q ++ + E+ + L +E + K+ +
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
Score = 125 bits (314), Expect = 2e-28
Identities = 192/928 (20%), Positives = 385/928 (41%), Gaps = 115/928 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
Q DD+ L SL + + +D +L + D + +E+ EKL E Q+
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ---DDSQRLVEQEVQEKLRETQE 1042
Query: 213 QEVVSDRVERR-------LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE 265
+ +ER L E E+ + +E RQ +L + +QEA +Q+ + +
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102
Query: 266 HE---GAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD 322
E +K K ++ QL +ELE S Q S + +L+ +L E
Sbjct: 1103 MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ 1162
Query: 323 RKGLQHQVSQISKQQSNYQ-------------------------------------DEQG 345
+ L + ++ Q+ Q D+ G
Sbjct: 1163 LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222
Query: 346 EDWRFRRG-------VEREKQDLEKQMSDL-RVQLNFSAMASELEEVKRCMERKDKEKAH 397
F+RG E L K DL + Q + ++++++ + + EK+
Sbjct: 1223 ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 398 LASQVENLTRELENGEKQQ--------------LQMLDRLKEIQNHFDTCEAERKHADLQ 443
+ +++++L R+L ++++ +++ + + +Q+ E +R A +
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 444 ISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERA 503
L E+ T Q E + + ++ A A EDL+ A+ ++ KLK++++E
Sbjct: 1343 RELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT-ARSAL---KLKNEEVESE 1398
Query: 504 LEKQSETVD--ELTGKNNQILKEKDELKTQLYAALQQ-IENLRKELNDVLTKRALQEEEL 560
E+ + EL + L+E L TQ A ++ +E LR ++ ++ +R +Q+ L
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
Query: 561 HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELK 620
E D+K +++L+ + + + + S L+ + + + E+I EL+
Sbjct: 1459 ---ELLSLDLKKRNQEVDLQ-QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 621 KSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLK-DLSDLTAQAKSRDEET 679
K + E Q ++ + + + +++ E +R + LK L L A +E
Sbjct: 1515 KDR--------ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENH 1566
Query: 680 ATIITQLKLERDVH-QRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKA 738
+ Q KL +++ QRE + + +L + E+ QEL + + E+H L
Sbjct: 1567 HKMECQQKLIKELEGQRETQRV--ALTHLTLDLEERSQELQAQ-SSQIHDLESHSTVLAR 1623
Query: 739 ESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISI 798
E E K R Q+E+L+ Q + LT++L + + E K + Q L+DQ R + I
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ---RTRQTKI 1680
Query: 799 EEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF----S 854
EE L E+ +L L+++ L T Q ++ +E K + S+E +K+
Sbjct: 1681 LEEDL---EQIKLSLRERGREL-TTQRQLMQERAEEGKGPSKA-QRGSLEHMKLILRDKE 1735
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNL----RHQLMLCRQQLRNLTENKE 910
+ + L E K +L+ + L + L ++++ +QQL+ E E
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Query: 911 SELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLE 970
+ Q L Q++ ++ L + +E L +E Q+ + ++++ AL+ + + A H+
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HM- 1852
Query: 971 SVPEKLSLLEDFKDFRDSCSSSERTDGR 998
++ E+ L+D K+ +GR
Sbjct: 1853 TLKERHGELQDHKEQARRLEEELAVEGR 1880
Score = 115 bits (288), Expect = 2e-25
Identities = 194/878 (22%), Positives = 395/878 (44%), Gaps = 135/878 (15%)
Query: 175 QIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTE 234
Q++ ++ EL R E K EE+ +KL+E++ Q+ + +L++L +E + +
Sbjct: 667 QLQKAEEAGAELQADLRDIQEEK---EEIQKKLSESRHQQ---EAATTQLEQLHQEAKRQ 720
Query: 235 RELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELE---LS 291
E++ R ++Q +EAL +++A A++ +L+ E ++ L ++L+ +
Sbjct: 721 EEVLAR--------AVQEKEALVREKA-------ALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 292 RRLLNQS--EGSRETLLHQVE--ELRTQLTKAEGDRKGLQHQVS----QISKQQSNYQDE 343
+ LL S E ++ + +V +L Q+ ++ +Q +V ++ ++S + E
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 344 QGEDWRFRRGVERE-KQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQV 402
+ R E+E K LE+Q A+ +EV + E+ +KE++
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQK------------AAHEKEVNQLREKWEKERSW---HQ 870
Query: 403 ENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI-SELTRHAEDATKQAERY 461
+ L + LE+ E++++++ RLKE Q + +A+R+ Q S L + + K+
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 462 LSELQQSEA----LKEEAEKRREDL---KLKAQES--IRQWKLK--HKKLERALEKQSET 510
L L Q++ ++ E+ R+D+ KLK QE+ I Q +L+ ++L+ A + +
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 511 VDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDI 570
+ L +++ +L++K +L+ +Q+E+L+ +L + L E+E+ K + ++
Sbjct: 991 LAALQEESSSLLQDKMDLQ-------KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043
Query: 571 KSHQADLELEVKNSLDTIHRLESE-----LKKQSKI-QSQMKVEKAHLEEEIAELKKSQA 624
Q +LE E K SL T+ +E E L++ I Q ++ + ++E E K+ A
Sbjct: 1044 NRIQKELERE-KASL-TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 625 QDKAKLLEMQESIKDLSAIRADLANKLAEE---ERAKKAVLKDLSDLTAQAKSRDEETAT 681
Q + E++E D A A L +L E+ +A L AQ + R T +
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
Query: 682 IITQLKLERD-----VHQRELKDLTSSLQSVKTKHEQNIQEL---------MKHFKKEKS 727
+ L E+ Q +L L S+LQ ++ EL + + +++
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221
Query: 728 EAENHIR------TLKAESLEEKNMAKIHRG------QLEKLKSQCDRLTEELTQNENEN 775
A + + L AE++ + K+H+ + L+ Q +L E LT E E
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASA-LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEK 1280
Query: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETE------------ 823
++ + Q L+ QL + ++ S E +E ++L + + L++
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 824 -QESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELK 882
+ +L + + A + VE S+ + D L +++ L+ EE++
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED----LRTARSALKLKNEEVE 1396
Query: 883 ERENREKNLRHQLMLCRQQLRNLTEN----------KESELQCLFQQIERQEQLLDEIHR 932
R + L+ Q L Q + L EN +E E++ L QI+ E+ E+ +
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK-QREMQK 1455
Query: 933 EKRDLLE-ETQRKDEEMGSLQDRVIALETSTQVALDHL 969
+LL + +++++E+ Q+++ LE V L+HL
Sbjct: 1456 AALELLSLDLKKRNQEVDLQQEQIQELEKCRSV-LEHL 1492
Score = 112 bits (281), Expect = 1e-24
Identities = 191/968 (19%), Positives = 416/968 (42%), Gaps = 115/968 (11%)
Query: 32 LPTVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYRE----YSNGQAGAIEHLKESLEQSI 87
L E+ ++V +++ L + + ++M+ RE +EH + SL ++
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEH-EASLSRNA 334
Query: 88 --DQLRSQRLLRNSGGRSISVTSLSASDLDG---GTGSELHHFPPTSPLK--DYGDPQGI 140
++L Q+++++ +T + + D G+G E +S DY D
Sbjct: 335 QEEKLSLQQVIKD-------ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKA 387
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRAL 200
+ R Q D+ Q Q +L +Q ++ + L +R + + L
Sbjct: 388 LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTL 447
Query: 201 EELTEKLNEAQKQEVVSDRVERRL-QELEREMRTERELVERRQDQLGLMSLQLQ----EA 255
T L + EV S ER L Q+ E+R + E++E+ +L ++++LQ A
Sbjct: 448 AGQTVDL----QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503
Query: 256 LKKQEAKADEHEGAIKNK------LRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQV 309
++E + +E A++ + L E ++++ EL R L S E L +
Sbjct: 504 QGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563
Query: 310 EELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLR 369
E+ L +AE ++++S ++ + E + R + L + ++ +
Sbjct: 564 TEVTAALARAE-------QSIAELSSSENTLKTEVAD----LRAAAVKLSALNEALALDK 612
Query: 370 VQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNH 429
V LN + E E C + E+A A QV +L EK++ + L E H
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQV-----DLAEAEKRR----EALWEKNTH 663
Query: 430 FDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQES 489
+ A LQ AE+A + + L ++Q+ KEE +K+ + + + + +
Sbjct: 664 LE--------AQLQ------KAEEAGAELQADLRDIQEE---KEEIQKKLSESRHQQEAA 706
Query: 490 IRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDV 549
Q + H++ +R Q E + + +++EK L+ +L A + ++L ++L +
Sbjct: 707 TTQLEQLHQEAKR----QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 550 LTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
+ + L E L +++ I+ + LE++++ ++ E+ + K++ + +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV-RCLKLELDTERSQ 821
Query: 610 AHLEEEIAELKKSQAQDKAK-LLEMQESI--KDLSAIRADLANKLAEEERAKKAVLKDLS 666
A E + A + +QA+ + K LE Q++ K+++ +R + + ++ L+ L
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
+ + R +E T + ++ +R+ + + + +Q K ++ E + +KE
Sbjct: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 727 SEAENHIRTL----KAESLEEKNMAKIHRGQLE----KLKSQCDRLTEELTQNENENKKL 778
++A + L K + L+E+ I + QL+ +LK + ++L + E+ L
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
Query: 779 KLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAA 838
L+ Q+E+ + + +++ R +E+ +++++L ET++ I KE++
Sbjct: 1002 LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ---EVQEKL--RETQE---YNRIQKELERE 1053
Query: 839 CKTFSKDSVEK---LKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQL 895
+ + +EK L V I + +L L ++++E + +K L Q+
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIR----------QQELSALRQDMQEAQGEQKELSAQM 1103
Query: 896 MLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRV 955
L RQ++ KE E L Q+ + E+ L+ H ++ L ++ + LQ R+
Sbjct: 1104 ELLRQEV------KEKEADFLAQEAQLLEE-LEASHITEQQLRASLWAQEAKAAQLQLRL 1156
Query: 956 IALETSTQ 963
+ E+ +
Sbjct: 1157 RSTESQLE 1164
Score = 106 bits (265), Expect = 1e-22
Identities = 148/690 (21%), Positives = 298/690 (43%), Gaps = 95/690 (13%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEV-----VSDRVERRLQELEREMRTERELVERR 241
S+ R E + + EK E Q++ + + D++E++LQ L R++ L+ +R
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 242 QDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGS 301
+ ++ ++ QLQEA ++ E K E +++++L + + Q +QELE ++ Q++G
Sbjct: 1777 EQEIVVLQQQLQEAREQGELK----EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
Query: 302 RETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER----- 356
E + + + L+ L +A K ++ +Q ++E + R + +E
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 357 --EKQDLEKQMSDLRVQLNFSAMASELE---------EVKRCMERKDKEKAHLASQVENL 405
E ++ EK + L+ Q A E+E + + ++ +D+E +E L
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE-------LEAL 1945
Query: 406 TRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD---LQISELTRHAEDATKQAERYL 462
E ++ Q+ R + +Q A + + L+ +EL+R E +T + L
Sbjct: 1946 RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 463 SELQQSEALKEEAEKRRE----DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKN 518
Q EEA + +E D L+ QE ++Q L++AL ++ E +
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ-------LQQALAQRDEELRHQ---- 2054
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
+E+++L + A Q EN+ +E ++ +R +EEE+ + +R+++ A E
Sbjct: 2055 ----QEREQLLEKSLAQRVQ-ENMIQEKQNLGQER--EEEEIRGLHQSVRELQLTLAQKE 2107
Query: 579 LEVKNSLDTIHRLESELKKQSKIQSQMKVE-------KAHLEEEIAELKKSQAQDKAKLL 631
E+ +T R E S S M+ + + L+ E+ L+ + Q +A+ +
Sbjct: 2108 QEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI 2167
Query: 632 EMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERD 691
E +E +DL A LA+ + + ++ + L A RD E + +L+L R
Sbjct: 2168 EWREKAQDL-------ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR 2220
Query: 692 VHQREL--KDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKI 749
++E +S + ++ EQ +Q + ++AE + +
Sbjct: 2221 ALEKERLHSPGATSTAELGSRGEQGVQ-------------LGEVSGVEAEPSPDGMEKQS 2267
Query: 750 HRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEA 809
R +LE L+ RL + ++ + N +L+ L+ ER K ++ E +R +
Sbjct: 2268 WRQRLEHLQQAVARLEIDRSRLQRHNVQLR---STLEQVERERRK---LKREAMRAAQAG 2321
Query: 810 RLQLKDQLLCLETEQESILGVIGKEIDAAC 839
L++ T+Q+ G K DA C
Sbjct: 2322 SLEISKATASSPTQQD---GRGQKNSDAKC 2348
Score = 88.2 bits (217), Expect = 4e-17
Identities = 151/741 (20%), Positives = 303/741 (40%), Gaps = 101/741 (13%)
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E+ + + D EKA L +V L+ L +KQ +K ++ + E
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELM 324
Query: 442 LQISELTRHAEDATKQAERYLSELQQ--------------------------SEALKEEA 475
+ L+R+A++ ++ + ++ Q S+ ++A
Sbjct: 325 EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384
Query: 476 EK----------RR----EDLKLK---AQESIR-------QWKLKHKKLERALEKQSETV 511
+K RR +DL+ + QE++ QW+ + K L + L+K +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444
Query: 512 DELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDI- 570
D L G+ + E D L + + E LR++L +VL + A + ++ + + D
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL-EVLEQEAWRLRRVNVELQLQGDSA 503
Query: 571 ----KSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM-----KVEKAHLEEEIAELKK 621
+ Q +L L V+ L KQS+ S++ +E +HLE E+ L++
Sbjct: 504 QGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGEL--LRQ 561
Query: 622 SQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERA-------KKAVLKDLSDLTAQAKS 674
Q + A L ++SI +LS+ L ++A+ A +A+ D L Q
Sbjct: 562 EQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ 621
Query: 675 RDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQN--IQELMKHFKKEKSEAENH 732
+EE ++ ++++ DL + + + E+N ++ ++ ++ +E +
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681
Query: 733 IRTLKAES-------LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCL 785
+R ++ E E ++ + QLE+L + R E L + E + L + L
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 786 KDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKD 845
+ +L+ E+ E L+ + A+ +L + L +Q S++ V +++ +T ++
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAK-ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQ- 799
Query: 846 SVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKN-LRHQLMLCRQQLRN 904
+ E ++ + D R AE + +L + E K L Q +++
Sbjct: 800 AKEVIQGEVRCLKLELDTERSQAEQERDA--AARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
Query: 905 LTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQV 964
L E E E Q++ + L+ + REK +L + + EM ++Q + T +
Sbjct: 858 LREKWEKERSWHQQELAK---ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
Query: 965 AL--DHLESVPEKLSLLEDF----KDFRDSCSSSE--RTDGRYSKYR------VRRNSLQ 1010
AL LE+ E++SLLE K+ D+ E R D + K + + + LQ
Sbjct: 915 ALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ 974
Query: 1011 HHQDDTKYRTKSFKGDRTFLE 1031
Q + K + + D L+
Sbjct: 975 EAQRELKEAARQHRDDLAALQ 995
Score = 66.6 bits (161), Expect = 1e-10
Identities = 119/561 (21%), Positives = 226/561 (40%), Gaps = 73/561 (13%)
Query: 473 EEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL 532
+EA++R+ L K Q + Q++ ++LE+ LE + + N DEL +L
Sbjct: 46 QEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRW--ENVEEPNLDELLVRL 103
Query: 533 YAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLE 592
Q+ E+L +V T+ L E+ + LR+ D+E K ++D +
Sbjct: 104 EEEQQRCESLA----EVNTQLRLHMEKADVVNKALRE------DVE---KLTVDWSRARD 150
Query: 593 SELKKQSKIQSQMKVEKAHLEEE---IAELKKSQAQDKAKLLEMQESIKDLSAIRADLAN 649
++K+S+ Q + + K +L+ E + L + + LEM+ SA DL
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK------SATDRDLME 204
Query: 650 KLAEEERAKKAVLKDLSDLTAQAKSRD-----------------------------EETA 680
AE R ++L LT A+SR+ E +
Sbjct: 205 LKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERS 264
Query: 681 TIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAE----NHIRTL 736
+ QLK + D+ + EL+D + L ++ T+ ++ ++ K K + E NH +
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELM 324
Query: 737 KAESLEEKNMAKIHRGQLEKLKSQCDRLTEE---LTQNENENKKLKLKYQCLKD-QLEER 792
+ E+ +N + + +K + EE + Q L+L ++
Sbjct: 325 EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384
Query: 793 EKHISIEEEHLRRMEEARLQLKDQLL-CLET-----EQESILGVIGKEIDAACK--TFSK 844
+K +++ L R +A L+ QL C E +Q GK + + T +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444
Query: 845 DSVEKLKVFSSGP-DIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLR 903
D++ V G D L +++ +L+ E L++ R + + +L L +
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504
Query: 904 NLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEE--TQRKDEEMGSLQDRVIALE-T 960
E ++ EL ++ ER +++L + ++ + L E T R+ E L+ ++ E T
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQT 564
Query: 961 STQVALDHLESVPEKLSLLED 981
AL E +LS E+
Sbjct: 565 EVTAALARAEQSIAELSSSEN 585
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 137 bits (344), Expect = 7e-32
Identities = 187/812 (23%), Positives = 353/812 (43%), Gaps = 119/812 (14%)
Query: 183 NRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--- 239
N L R + +A +R LEE AQ + + +R+ + + + E+ ++ LVE
Sbjct: 1863 NERLRRLAEDEAFQRRRLEE-----QAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHE---GAIKNKLRQTETEKNQLEQELELSRRLLN 296
R++ Q+ L L+ + +K A E E G I++ T K Q E E R+L
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 297 QSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E R +V++ +A RK +V ++ + RR ER
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA----------RRLRER 2027
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
+Q+ +Q+ QL A L+ +EKAH A V+ +EL+ +Q+
Sbjct: 2028 AEQESARQL-----QLAQEAAQKRLQA---------EEKAH-AFAVQQKEQELQQTLQQE 2072
Query: 417 LQMLDRLK-----------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
+LD+L+ E + E E + Q+ E R + A +QA+
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKL------KHKKL-ERALEKQSETVDELTGKN 518
+E L++EAE+ Q ++RQ + KHKK E+ L ++++ ELT
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Q L+E D K L LQ+ L+ E + +R+ EEEL S ++ ++ +A +E
Sbjct: 2193 LQ-LEETDHQKNLLDEELQR---LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248
Query: 579 LE-----VKNSLDTIHRLESELKKQSKIQSQ-----MKVEKAHLEEEIAE--LKKSQAQD 626
E +++ +T L+ E +K ++ + + ++A ++AE L + +A
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308
Query: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL 686
+ L E +++++ + ++A+ ++E A++ + D A+ EET L
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 687 KLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ ER QR+L ++++ + +K ++ + +E + F+K+ E + + +
Sbjct: 2369 EAER---QRQL-EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
E+ + + Q ++ +RL E + + E E +KL+ + + L+ + EE + ++++
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ---TVQQ 2481
Query: 801 EHL----RRMEEARLQLKDQLLCLET--EQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
E L + ++++ L KD LL E EQE A + +D V K +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEK----------AKLEQLFQDEVAKAQ--- 2528
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
+ + R + + + Q L ++E R+ + K+ ELQ
Sbjct: 2529 ---QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV-----------RRKQEELQ 2574
Query: 915 CLFQQIERQEQLLDEIH---REKRDLLEETQR 943
L QQ +QE+LL E + RE+ LLEE R
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 131 bits (329), Expect = 4e-30
Identities = 213/1027 (20%), Positives = 410/1027 (39%), Gaps = 139/1027 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSI-------- 87
++ E+ + + R L Q+ + L YRE ++ ++ + EQ
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 88 ---DQLRSQRLL----RNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGI 140
+QLR ++ L G + + ++ EL + L+ P
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA-- 1300
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA- 199
K+ + ++G V + + L + L L+S+ I+ + R + R AE +RA
Sbjct: 1301 KKPKVQSGSESVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-AEQQRAE 1357
Query: 200 -LEELTEKLNEAQKQEVVSD-------RVERRLQELEREMRTE----RELVERRQDQLGL 247
E L E +KQ +++ + ER +EL++ M+ E E Q Q
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 248 MSLQLQEALKKQEA----KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRE 303
+ +LQ+ + EA KA + E A +++LR E E + +LE + R +EG +
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 304 TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEK 363
L + EE Q +A+ + + L+ QV S+++ + E + REKQ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 364 QMSDLRVQLNFSAMASELEEVKRCME--------------RKDKEKAHLASQVENLTREL 409
+ +LR+Q + EV+R + ++A A + L R L
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ Q+ + + E R+ A+ ++ A +A + + QQ
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 470 ALKEEAEKRREDLKLKA-------QESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ EAEK++E+ + +A ++++RQ +L ++LE+ + T + +++
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 523 K-----EKDELKTQL----YAALQ---------------QIENLRKELNDVLTKRALQEE 558
+ E+ E + QL A LQ ++ +R E+ +L +A EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI-QSQMKVEKAHLEEEIA 617
E S EK + +A E+ + L E K+Q ++ + ++A E +A
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
E + + E + ++K+ A L +LAE+E ++ + L + AQ K+ E
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERL-RRLAEDEAFQR---RRLEEQAAQHKADIE 1892
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE---KSEAE---N 731
E + QL+ D K L + + E+ I L F+K K+E E
Sbjct: 1893 ER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-----------ENENKKLKL 780
IR+ ++L K A++ + +L ++ +R E + + K
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 781 KYQCLKDQLEE-REKHISIEEEHLRRMEEAR-----------------LQLKDQLLCLET 822
+ + LK ++EE R E+E R+++ A+ +Q K+Q L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 823 EQE-SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+QE S+L + E +AA + + + E+ +V R A+S+ +++ E L
Sbjct: 2070 QQEQSVLDQLRGEAEAARR--AAEEAEEARV---------QAEREAAQSRRQVE-EAERL 2117
Query: 882 KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
K+ + R Q ++LR E + + Q RQ+Q D + + E+T
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 942 QRKDEEM 948
R+ ++
Sbjct: 2178 LRQKAQV 2184
Score = 123 bits (309), Expect = 8e-28
Identities = 188/972 (19%), Positives = 393/972 (40%), Gaps = 147/972 (15%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE------------------A 210
R L E + + E RR++ AE +RA EE +L A
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 211 QKQEVVSDRVERRLQELEREMRTERELVER--RQDQLGLMSL----QLQEALKKQEAKAD 264
Q++ + E++ +E ERE R + E+ RQ +L L QL E +Q A+
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL-----TKA 319
+ ++ + Q E ++ LE+EL +R + R+ L ++ ++R ++ +KA
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 320 EGDRKGLQHQVSQISKQ------------------------QSNYQDEQGEDWRFRRGVE 355
+ + S+ SKQ ++ Q + E+ R+ E
Sbjct: 1773 RAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 356 REKQDLEK-----QMSDLRVQLNFSAMASELE-------------EVKRCMERKDKEKAH 397
E+ EK + + L+ + + E E + +R E+ + KA
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 398 LASQVENLTR----ELENGE-------KQQLQMLDRLKEIQNHFDTCEAERKHADLQISE 446
+ ++ L + ELE + +Q+ Q+ + + ++ F+ A + +L++
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
+ +AED + E+ E + L E E+RR + + + Q+S+ + ++ + ALE+
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHS---- 562
V+ L K + + ++ + + LQ + + KR EE+ H+
Sbjct: 2011 ----VERLKAKVEEARRLRERAEQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQ 2059
Query: 563 -KEEKLRDIKSHQADLELEVKNSLDTIHRLESELK------KQSKIQSQMKVEKA-HLEE 614
KE++L+ + + +++ + R E + ++ QS+ +VE+A L++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL---KDLSDLTAQ 671
E +++AQ +A ++++ + +A RA +++A A + K ++ T +
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ-------------NIQEL 718
K++ E+ T + +L+LE HQ+ L D LQ +K + + +++
Sbjct: 2180 QKAQVEQELTTL-RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 719 MKHFKKEKS--EAENHIRTLK---------AESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
M+ K K+ EAEN L+ E E+ +L + RL +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++ + + L K K Q + + E E L++ +E ++Q L+ ++E +
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQM 2353
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ +E +T + +L++ + + ++ ++ + + + +++
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEE 2412
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET---QRK 944
H+ L Q+ L + E + Q ER + + E+ REK L +E Q K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 945 DEEMGSLQDRVIALETST--QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKY 1002
EEM ++Q + ET Q L +S+ ++ +E K + E + +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1003 RVRRNSLQHHQD 1014
+R Q Q+
Sbjct: 2533 EQQRQQQQMEQE 2544
Score = 119 bits (299), Expect = 1e-26
Identities = 151/702 (21%), Positives = 313/702 (44%), Gaps = 84/702 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR-LQE 226
+R + + +R + E +R+ + AE +R E E++ ++ E + R + L+E
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 227 LER---EMRTERELVER-RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK-------LR 275
+ER ++ R L ER Q+ + L + A K+ +A+ H A++ K L+
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q ++ +QL E E +RR ++E +R + + R Q+ +AE ++ + Q ++
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 336 QQSNYQD--EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDK 393
Q+ + ++ E RR + +KQ +D +E+E+ K+ E+ +
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-----------AEMEKHKKFAEQTLR 2179
Query: 394 EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
+KA + ++ L +LE + Q+ + + L+ ++ +R + ++ + E+
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 454 ATKQAERYLSELQQ---------SEALKEEAEKRRE------DLKLKAQESIRQWKLKHK 498
+K R +E + L+EEAEK ++ L + AQE+ R +L
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA-- 2297
Query: 499 KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE 558
E L +Q +++ + Q ++E LK + LQQ + L +E R LQE+
Sbjct: 2298 --EEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQE-----QARRLQED 2349
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDT---IHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ + + Q LE E + L+ RL+ + + S+ Q++ + + ++
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 616 IAELKKS------QAQDKAKL---LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
E+ + Q+K L LE+Q D A R L +AE ER K+ + ++
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEAK 2467
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
L Q KS + +T V Q +L T +LQ + ++ + + ++EK
Sbjct: 2468 LL--QLKSEEMQT------------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
++ E + A++ + + + + Q+E+ + + EE + ++E ++ + Q
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
QLE++ + ++E L + E +L++QL LE + + L
Sbjct: 2574 QQLEQQRR----QQEEL--LAEENQRLREQLQLLEEQHRAAL 2609
Score = 106 bits (264), Expect = 1e-22
Identities = 156/791 (19%), Positives = 333/791 (42%), Gaps = 86/791 (10%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLG 246
+++ + + ++ ++E + + ++ + + + E R M E L E+++ +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 247 LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL 306
+++ AL+KQ A+ H A Q E E +L+Q ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQA----KAQAEREAKELQQRMQ----------------- 1398
Query: 307 HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMS 366
+V A+ ++ +Q ++ Q+ +QS+ + Q + R ER + +E+++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKA-RQAEAAERSRLRIEEEIR 1455
Query: 367 DLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI 426
+R+QL E ++++ +++ L E E Q+ Q + + +
Sbjct: 1456 VVRLQL----------------EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
+ ++ A+++++ + +A ++ +R L L++ EEAE+R L+
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR---LRQAE 1556
Query: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
E RQ ++ + +R+ E EL K ++ +L+ L + LR+E
Sbjct: 1557 VERARQVQVALETAQRSAEA------ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 547 NDVLTKRALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+RA Q+ E ++EE R+++ Q L+ +L RL++E Q K +Q
Sbjct: 1611 E----RRAQQQAEAERAREEAERELERWQ----LKANEALRL--RLQAEEVAQQKSLAQA 1660
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+ EK E E ++ +A+++A + +E + + LA A++ A + L L
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQA--VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 666 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 725
T Q + + + + +L+ E ++ ++L + L V+ + E + + ++
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 726 KSEAENHIRTLKAESLEEKNMAKIH---RGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+S +E + L+AE+ + +A+ R E+ K Q E+ + E +++ +
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 783 QC-------LKDQLEEREKHISIEEEHLRRMEE----ARLQLKDQLLCLETEQESILGVI 831
LK + E K E E LRR+ E R +L++Q + + E L +
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 832 GKEIDAAC---KTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
K D+ K +D++ + + A K +L+ E + R N E
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIRSNAE 1956
Query: 889 KNLR--HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR--- 943
LR Q L + R L +E + +++++ +E R+++ LEE +R
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 944 KDEEMGSLQDR 954
K EE L++R
Sbjct: 2017 KVEEARRLRER 2027
Score = 99.4 bits (246), Expect = 2e-20
Identities = 147/659 (22%), Positives = 294/659 (44%), Gaps = 80/659 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE + QL G ++ R R ++ + R A+++R +EE A++
Sbjct: 2071 QEQSVLDQLRGEAEAAR-------RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
Q + + ++L +E E+E R Q + Q AL++++A AD K
Sbjct: 2124 QAQARAQAQAAAEKLRKE--AEQEAARRAQAE--------QAALRQKQA-ADAEMEKHKK 2172
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH---- 328
QT +K Q+EQEL R L +++ + L +++ L+ + T+A R ++
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 329 ---QVSQISKQQSNYQDEQG----EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
Q+ ++SK ++ + E D + +E+ + KQ+++ +L+ +A
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----- 2287
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E R + +++ A + E + +E + Q +Q RLK EAE
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKE----KMQAVQEATRLK--------AEAELLQQQ 2335
Query: 442 LQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRR--------EDLKLKAQESIRQ 492
+++ E R ++ +Q + L+E Q EAE++R E LKL+ E R
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
+ +R KQ+E + E + +EK L L QQ ++ + L + + +
Sbjct: 2396 QARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKIQSQ--MKVEK 609
++E+L +E KL +KS + + + +T +S L +K S +Q + ++ EK
Sbjct: 2455 LEREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 610 AHLE----EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
A LE +E+A+ ++ + + + + +M++ + L A + + E E + ++L
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 666 SDLTAQAKSRD----EETATIITQLKLERDVHQREL---KDLTSSLQSVKTKHEQNIQEL 718
L Q + ++ EE + QL+L + H+ L +++T+S Q TK N ++
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS-QVAATKTLPNGRDA 2632
Query: 719 MKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 773
+ E +E E+ R + A+ L+E + + +L++L +Q +EL + E+
Sbjct: 2633 LDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGI--LSAEELQRL-AQGHTTVDELARRED 2687
Score = 62.0 bits (149), Expect = 3e-09
Identities = 121/592 (20%), Positives = 239/592 (40%), Gaps = 79/592 (13%)
Query: 392 DKEKAHLASQVENLTRELENGEKQQLQM---LDRLKEIQNHFDTCEAERKHADLQISELT 448
++E + + L + LE G +++ + + LK+I+ + CE H L
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR----LRLP 1010
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
E A + A+R ++E Q+++A E K L +A++ + AL + S
Sbjct: 1011 LDKEPARECAQR-IAEQQKAQAEVEGLGKGVARLSAEAEKVL------------ALPEPS 1057
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
L + L + +++++ L+++ K ++ V+ EE L + EE+L+
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKL----KTISLVIRGTQGAEEVLRAHEEQLK 1113
Query: 569 DIKSHQADL-ELEV-KNSLD-----------TIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ A L ELE K SL T L EL+ ++ +++ + E
Sbjct: 1114 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1173
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
+ ++ AQ LLE +++ + +R +L + R + L A+ R
Sbjct: 1174 VERWRERVAQ----LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 676 DEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT 735
E+ I + L RE +L +H + ++E + A+ +I
Sbjct: 1230 QEQ----IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF-------AKQYINA 1278
Query: 736 LKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE--NENKKLKLKYQCLKDQLEERE 793
+K L+ ++ QLE + S + + E L+ Y L +
Sbjct: 1279 IKDYELQ----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K IS E LRRMEE +L +Q E E+ + E++AA + ++ ++
Sbjct: 1335 KFIS---ETLRRMEEEE-RLAEQQRAEERERLA-------EVEAALE-------KQRQLA 1376
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESEL 913
+ R E + ++Q EE+ RE + + Q +++L+ L ++ E+E+
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 914 QCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA 965
Q +Q E E+ I E R + + + + + G + + AL + A
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 137 bits (344), Expect = 7e-32
Identities = 187/812 (23%), Positives = 353/812 (43%), Gaps = 119/812 (14%)
Query: 183 NRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--- 239
N L R + +A +R LEE AQ + + +R+ + + + E+ ++ LVE
Sbjct: 1867 NERLRRLAEDEAFQRRRLEE-----QAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHE---GAIKNKLRQTETEKNQLEQELELSRRLLN 296
R++ Q+ L L+ + +K A E E G I++ T K Q E E R+L
Sbjct: 1922 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981
Query: 297 QSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E R +V++ +A RK +V ++ + RR ER
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA----------RRLRER 2031
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
+Q+ +Q+ QL A L+ +EKAH A V+ +EL+ +Q+
Sbjct: 2032 AEQESARQL-----QLAQEAAQKRLQA---------EEKAH-AFAVQQKEQELQQTLQQE 2076
Query: 417 LQMLDRLK-----------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
+LD+L+ E + E E + Q+ E R + A +QA+
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKL------KHKKL-ERALEKQSETVDELTGKN 518
+E L++EAE+ Q ++RQ + KHKK E+ L ++++ ELT
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2196
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Q L+E D K L LQ+ L+ E + +R+ EEEL S ++ ++ +A +E
Sbjct: 2197 LQ-LEETDHQKNLLDEELQR---LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252
Query: 579 LE-----VKNSLDTIHRLESELKKQSKIQSQ-----MKVEKAHLEEEIAE--LKKSQAQD 626
E +++ +T L+ E +K ++ + + ++A ++AE L + +A
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2312
Query: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL 686
+ L E +++++ + ++A+ ++E A++ + D A+ EET L
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2372
Query: 687 KLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ ER QR+L ++++ + +K ++ + +E + F+K+ E + + +
Sbjct: 2373 EAER---QRQL-EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
E+ + + Q ++ +RL E + + E E +KL+ + + L+ + EE + ++++
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ---TVQQ 2485
Query: 801 EHL----RRMEEARLQLKDQLLCLET--EQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
E L + ++++ L KD LL E EQE A + +D V K +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEK----------AKLEQLFQDEVAKAQ--- 2532
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
+ + R + + + Q L ++E R+ + K+ ELQ
Sbjct: 2533 ---QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV-----------RRKQEELQ 2578
Query: 915 CLFQQIERQEQLLDEIH---REKRDLLEETQR 943
L QQ +QE+LL E + RE+ LLEE R
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Score = 131 bits (329), Expect = 4e-30
Identities = 213/1027 (20%), Positives = 410/1027 (39%), Gaps = 139/1027 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSI-------- 87
++ E+ + + R L Q+ + L YRE ++ ++ + EQ
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 88 ---DQLRSQRLL----RNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGI 140
+QLR ++ L G + + ++ EL + L+ P
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA-- 1304
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA- 199
K+ + ++G V + + L + L L+S+ I+ + R + R AE +RA
Sbjct: 1305 KKPKVQSGSESVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-AEQQRAE 1361
Query: 200 -LEELTEKLNEAQKQEVVSD-------RVERRLQELEREMRTE----RELVERRQDQLGL 247
E L E +KQ +++ + ER +EL++ M+ E E Q Q
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 248 MSLQLQEALKKQEA----KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRE 303
+ +LQ+ + EA KA + E A +++LR E E + +LE + R +EG +
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 304 TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEK 363
L + EE Q +A+ + + L+ QV S+++ + E + REKQ +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 364 QMSDLRVQLNFSAMASELEEVKRCME--------------RKDKEKAHLASQVENLTREL 409
+ +LR+Q + EV+R + ++A A + L R L
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ Q+ + + E R+ A+ ++ A +A + + QQ
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 470 ALKEEAEKRREDLKLKA-------QESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ EAEK++E+ + +A ++++RQ +L ++LE+ + T + +++
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720
Query: 523 K-----EKDELKTQL----YAALQ---------------QIENLRKELNDVLTKRALQEE 558
+ E+ E + QL A LQ ++ +R E+ +L +A EE
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI-QSQMKVEKAHLEEEIA 617
E S EK + +A E+ + L E K+Q ++ + ++A E +A
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
E + + E + ++K+ A L +LAE+E ++ + L + AQ K+ E
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERL-RRLAEDEAFQR---RRLEEQAAQHKADIE 1896
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE---KSEAE---N 731
E + QL+ D K L + + E+ I L F+K K+E E
Sbjct: 1897 ER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-----------ENENKKLKL 780
IR+ ++L K A++ + +L ++ +R E + + K
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 781 KYQCLKDQLEE-REKHISIEEEHLRRMEEAR-----------------LQLKDQLLCLET 822
+ + LK ++EE R E+E R+++ A+ +Q K+Q L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 823 EQE-SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+QE S+L + E +AA + + + E+ +V R A+S+ +++ E L
Sbjct: 2074 QQEQSVLDQLRGEAEAARR--AAEEAEEARV---------QAEREAAQSRRQVE-EAERL 2121
Query: 882 KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
K+ + R Q ++LR E + + Q RQ+Q D + + E+T
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 942 QRKDEEM 948
R+ ++
Sbjct: 2182 LRQKAQV 2188
Score = 123 bits (309), Expect = 8e-28
Identities = 188/972 (19%), Positives = 393/972 (40%), Gaps = 147/972 (15%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE------------------A 210
R L E + + E RR++ AE +RA EE +L A
Sbjct: 1598 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656
Query: 211 QKQEVVSDRVERRLQELEREMRTERELVER--RQDQLGLMSL----QLQEALKKQEAKAD 264
Q++ + E++ +E ERE R + E+ RQ +L L QL E +Q A+
Sbjct: 1657 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1716
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL-----TKA 319
+ ++ + Q E ++ LE+EL +R + R+ L ++ ++R ++ +KA
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1776
Query: 320 EGDRKGLQHQVSQISKQ------------------------QSNYQDEQGEDWRFRRGVE 355
+ + S+ SKQ ++ Q + E+ R+ E
Sbjct: 1777 RAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 356 REKQDLEK-----QMSDLRVQLNFSAMASELE-------------EVKRCMERKDKEKAH 397
E+ EK + + L+ + + E E + +R E+ + KA
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 398 LASQVENLTR----ELENGE-------KQQLQMLDRLKEIQNHFDTCEAERKHADLQISE 446
+ ++ L + ELE + +Q+ Q+ + + ++ F+ A + +L++
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
+ +AED + E+ E + L E E+RR + + + Q+S+ + ++ + ALE+
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHS---- 562
V+ L K + + ++ + + LQ + + KR EE+ H+
Sbjct: 2015 ----VERLKAKVEEARRLRERAEQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQ 2063
Query: 563 -KEEKLRDIKSHQADLELEVKNSLDTIHRLESELK------KQSKIQSQMKVEKA-HLEE 614
KE++L+ + + +++ + R E + ++ QS+ +VE+A L++
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL---KDLSDLTAQ 671
E +++AQ +A ++++ + +A RA +++A A + K ++ T +
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ-------------NIQEL 718
K++ E+ T + +L+LE HQ+ L D LQ +K + + +++
Sbjct: 2184 QKAQVEQELTTL-RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 719 MKHFKKEKS--EAENHIRTLK---------AESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
M+ K K+ EAEN L+ E E+ +L + RL +
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++ + + L K K Q + + E E L++ +E ++Q L+ ++E +
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQM 2357
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ +E +T + +L++ + + ++ ++ + + + +++
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEE 2416
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET---QRK 944
H+ L Q+ L + E + Q ER + + E+ REK L +E Q K
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 945 DEEMGSLQDRVIALETST--QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKY 1002
EEM ++Q + ET Q L +S+ ++ +E K + E + +
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 1003 RVRRNSLQHHQD 1014
+R Q Q+
Sbjct: 2537 EQQRQQQQMEQE 2548
Score = 119 bits (299), Expect = 1e-26
Identities = 151/702 (21%), Positives = 313/702 (44%), Gaps = 84/702 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR-LQE 226
+R + + +R + E +R+ + AE +R E E++ ++ E + R + L+E
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 227 LER---EMRTERELVER-RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK-------LR 275
+ER ++ R L ER Q+ + L + A K+ +A+ H A++ K L+
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q ++ +QL E E +RR ++E +R + + R Q+ +AE ++ + Q ++
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 336 QQSNYQD--EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDK 393
Q+ + ++ E RR + +KQ +D +E+E+ K+ E+ +
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-----------AEMEKHKKFAEQTLR 2183
Query: 394 EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
+KA + ++ L +LE + Q+ + + L+ ++ +R + ++ + E+
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 454 ATKQAERYLSELQQ---------SEALKEEAEKRRE------DLKLKAQESIRQWKLKHK 498
+K R +E + L+EEAEK ++ L + AQE+ R +L
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA-- 2301
Query: 499 KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE 558
E L +Q +++ + Q ++E LK + LQQ + L +E R LQE+
Sbjct: 2302 --EEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQE-----QARRLQED 2353
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDT---IHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ + + Q LE E + L+ RL+ + + S+ Q++ + + ++
Sbjct: 2354 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2413
Query: 616 IAELKKS------QAQDKAKL---LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
E+ + Q+K L LE+Q D A R L +AE ER K+ + ++
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEAK 2471
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
L Q KS + +T V Q +L T +LQ + ++ + + ++EK
Sbjct: 2472 LL--QLKSEEMQT------------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
++ E + A++ + + + + Q+E+ + + EE + ++E ++ + Q
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
QLE++ + ++E L + E +L++QL LE + + L
Sbjct: 2578 QQLEQQRR----QQEEL--LAEENQRLREQLQLLEEQHRAAL 2613
Score = 106 bits (264), Expect = 1e-22
Identities = 156/791 (19%), Positives = 333/791 (42%), Gaps = 86/791 (10%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLG 246
+++ + + ++ ++E + + ++ + + + E R M E L E+++ +
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363
Query: 247 LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL 306
+++ AL+KQ A+ H A Q E E +L+Q ++
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQA----KAQAEREAKELQQRMQ----------------- 1402
Query: 307 HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMS 366
+V A+ ++ +Q ++ Q+ +QS+ + Q + R ER + +E+++
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKA-RQAEAAERSRLRIEEEIR 1459
Query: 367 DLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI 426
+R+QL E ++++ +++ L E E Q+ Q + + +
Sbjct: 1460 VVRLQL----------------EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
+ ++ A+++++ + +A ++ +R L L++ EEAE+R L+
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR---LRQAE 1560
Query: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
E RQ ++ + +R+ E EL K ++ +L+ L + LR+E
Sbjct: 1561 VERARQVQVALETAQRSAEA------ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 547 NDVLTKRALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+RA Q+ E ++EE R+++ Q L+ +L RL++E Q K +Q
Sbjct: 1615 E----RRAQQQAEAERAREEAERELERWQ----LKANEALRL--RLQAEEVAQQKSLAQA 1664
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+ EK E E ++ +A+++A + +E + + LA A++ A + L L
Sbjct: 1665 EAEKQKEEAEREARRRGKAEEQA--VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 666 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 725
T Q + + + + +L+ E ++ ++L + L V+ + E + + ++
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782
Query: 726 KSEAENHIRTLKAESLEEKNMAKIH---RGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+S +E + L+AE+ + +A+ R E+ K Q E+ + E +++ +
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842
Query: 783 QC-------LKDQLEEREKHISIEEEHLRRMEE----ARLQLKDQLLCLETEQESILGVI 831
LK + E K E E LRR+ E R +L++Q + + E L +
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Query: 832 GKEIDAAC---KTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
K D+ K +D++ + + A K +L+ E + R N E
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIRSNAE 1960
Query: 889 KNLR--HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR--- 943
LR Q L + R L +E + +++++ +E R+++ LEE +R
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 944 KDEEMGSLQDR 954
K EE L++R
Sbjct: 2021 KVEEARRLRER 2031
Score = 99.4 bits (246), Expect = 2e-20
Identities = 147/659 (22%), Positives = 294/659 (44%), Gaps = 80/659 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE + QL G ++ R R ++ + R A+++R +EE A++
Sbjct: 2075 QEQSVLDQLRGEAEAAR-------RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
Q + + ++L +E E+E R Q + Q AL++++A AD K
Sbjct: 2128 QAQARAQAQAAAEKLRKE--AEQEAARRAQAE--------QAALRQKQA-ADAEMEKHKK 2176
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH---- 328
QT +K Q+EQEL R L +++ + L +++ L+ + T+A R ++
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 329 ---QVSQISKQQSNYQDEQG----EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
Q+ ++SK ++ + E D + +E+ + KQ+++ +L+ +A
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----- 2291
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E R + +++ A + E + +E + Q +Q RLK EAE
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKE----KMQAVQEATRLK--------AEAELLQQQ 2339
Query: 442 LQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRR--------EDLKLKAQESIRQ 492
+++ E R ++ +Q + L+E Q EAE++R E LKL+ E R
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
+ +R KQ+E + E + +EK L L QQ ++ + L + + +
Sbjct: 2400 QARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKIQSQ--MKVEK 609
++E+L +E KL +KS + + + +T +S L +K S +Q + ++ EK
Sbjct: 2459 LEREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2517
Query: 610 AHLE----EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
A LE +E+A+ ++ + + + + +M++ + L A + + E E + ++L
Sbjct: 2518 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2577
Query: 666 SDLTAQAKSRD----EETATIITQLKLERDVHQREL---KDLTSSLQSVKTKHEQNIQEL 718
L Q + ++ EE + QL+L + H+ L +++T+S Q TK N ++
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS-QVAATKTLPNGRDA 2636
Query: 719 MKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 773
+ E +E E+ R + A+ L+E + + +L++L +Q +EL + E+
Sbjct: 2637 LDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGI--LSAEELQRL-AQGHTTVDELARRED 2691
Score = 62.0 bits (149), Expect = 3e-09
Identities = 121/592 (20%), Positives = 239/592 (40%), Gaps = 79/592 (13%)
Query: 392 DKEKAHLASQVENLTRELENGEKQQLQM---LDRLKEIQNHFDTCEAERKHADLQISELT 448
++E + + L + LE G +++ + + LK+I+ + CE H L
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR----LRLP 1014
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
E A + A+R ++E Q+++A E K L +A++ + AL + S
Sbjct: 1015 LDKEPARECAQR-IAEQQKAQAEVEGLGKGVARLSAEAEKVL------------ALPEPS 1061
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
L + L + +++++ L+++ K ++ V+ EE L + EE+L+
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKL----KTISLVIRGTQGAEEVLRAHEEQLK 1117
Query: 569 DIKSHQADL-ELEV-KNSLD-----------TIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ A L ELE K SL T L EL+ ++ +++ + E
Sbjct: 1118 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1177
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
+ ++ AQ LLE +++ + +R +L + R + L A+ R
Sbjct: 1178 VERWRERVAQ----LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233
Query: 676 DEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT 735
E+ I + L RE +L +H + ++E + A+ +I
Sbjct: 1234 QEQ----IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF-------AKQYINA 1282
Query: 736 LKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE--NENKKLKLKYQCLKDQLEERE 793
+K L+ ++ QLE + S + + E L+ Y L +
Sbjct: 1283 IKDYELQ----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1338
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K IS E LRRMEE +L +Q E E+ + E++AA + ++ ++
Sbjct: 1339 KFIS---ETLRRMEEEE-RLAEQQRAEERERLA-------EVEAALE-------KQRQLA 1380
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESEL 913
+ R E + ++Q EE+ RE + + Q +++L+ L ++ E+E+
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437
Query: 914 QCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA 965
Q +Q E E+ I E R + + + + + G + + AL + A
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 137 bits (344), Expect = 7e-32
Identities = 187/812 (23%), Positives = 353/812 (43%), Gaps = 119/812 (14%)
Query: 183 NRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--- 239
N L R + +A +R LEE AQ + + +R+ + + + E+ ++ LVE
Sbjct: 1863 NERLRRLAEDEAFQRRRLEE-----QAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHE---GAIKNKLRQTETEKNQLEQELELSRRLLN 296
R++ Q+ L L+ + +K A E E G I++ T K Q E E R+L
Sbjct: 1918 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 297 QSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E R +V++ +A RK +V ++ + RR ER
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA----------RRLRER 2027
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
+Q+ +Q+ QL A L+ +EKAH A V+ +EL+ +Q+
Sbjct: 2028 AEQESARQL-----QLAQEAAQKRLQA---------EEKAH-AFAVQQKEQELQQTLQQE 2072
Query: 417 LQMLDRLK-----------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
+LD+L+ E + E E + Q+ E R + A +QA+
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKL------KHKKL-ERALEKQSETVDELTGKN 518
+E L++EAE+ Q ++RQ + KHKK E+ L ++++ ELT
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Q L+E D K L LQ+ L+ E + +R+ EEEL S ++ ++ +A +E
Sbjct: 2193 LQ-LEETDHQKNLLDEELQR---LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248
Query: 579 LE-----VKNSLDTIHRLESELKKQSKIQSQ-----MKVEKAHLEEEIAE--LKKSQAQD 626
E +++ +T L+ E +K ++ + + ++A ++AE L + +A
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2308
Query: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL 686
+ L E +++++ + ++A+ ++E A++ + D A+ EET L
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 687 KLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ ER QR+L ++++ + +K ++ + +E + F+K+ E + + +
Sbjct: 2369 EAER---QRQL-EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
E+ + + Q ++ +RL E + + E E +KL+ + + L+ + EE + ++++
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ---TVQQ 2481
Query: 801 EHL----RRMEEARLQLKDQLLCLET--EQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
E L + ++++ L KD LL E EQE A + +D V K +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEK----------AKLEQLFQDEVAKAQ--- 2528
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
+ + R + + + Q L ++E R+ + K+ ELQ
Sbjct: 2529 ---QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV-----------RRKQEELQ 2574
Query: 915 CLFQQIERQEQLLDEIH---REKRDLLEETQR 943
L QQ +QE+LL E + RE+ LLEE R
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 131 bits (329), Expect = 4e-30
Identities = 213/1027 (20%), Positives = 410/1027 (39%), Gaps = 139/1027 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSI-------- 87
++ E+ + + R L Q+ + L YRE ++ ++ + EQ
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 88 ---DQLRSQRLL----RNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGI 140
+QLR ++ L G + + ++ EL + L+ P
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA-- 1300
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA- 199
K+ + ++G V + + L + L L+S+ I+ + R + R AE +RA
Sbjct: 1301 KKPKVQSGSESVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-AEQQRAE 1357
Query: 200 -LEELTEKLNEAQKQEVVSD-------RVERRLQELEREMRTE----RELVERRQDQLGL 247
E L E +KQ +++ + ER +EL++ M+ E E Q Q
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 248 MSLQLQEALKKQEA----KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRE 303
+ +LQ+ + EA KA + E A +++LR E E + +LE + R +EG +
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 304 TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEK 363
L + EE Q +A+ + + L+ QV S+++ + E + REKQ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 364 QMSDLRVQLNFSAMASELEEVKRCME--------------RKDKEKAHLASQVENLTREL 409
+ +LR+Q + EV+R + ++A A + L R L
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ Q+ + + E R+ A+ ++ A +A + + QQ
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 470 ALKEEAEKRREDLKLKA-------QESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ EAEK++E+ + +A ++++RQ +L ++LE+ + T + +++
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 523 K-----EKDELKTQL----YAALQ---------------QIENLRKELNDVLTKRALQEE 558
+ E+ E + QL A LQ ++ +R E+ +L +A EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI-QSQMKVEKAHLEEEIA 617
E S EK + +A E+ + L E K+Q ++ + ++A E +A
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
E + + E + ++K+ A L +LAE+E ++ + L + AQ K+ E
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERL-RRLAEDEAFQR---RRLEEQAAQHKADIE 1892
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE---KSEAE---N 731
E + QL+ D K L + + E+ I L F+K K+E E
Sbjct: 1893 ER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-----------ENENKKLKL 780
IR+ ++L K A++ + +L ++ +R E + + K
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 781 KYQCLKDQLEE-REKHISIEEEHLRRMEEAR-----------------LQLKDQLLCLET 822
+ + LK ++EE R E+E R+++ A+ +Q K+Q L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 823 EQE-SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+QE S+L + E +AA + + + E+ +V R A+S+ +++ E L
Sbjct: 2070 QQEQSVLDQLRGEAEAARR--AAEEAEEARV---------QAEREAAQSRRQVE-EAERL 2117
Query: 882 KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
K+ + R Q ++LR E + + Q RQ+Q D + + E+T
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 942 QRKDEEM 948
R+ ++
Sbjct: 2178 LRQKAQV 2184
Score = 123 bits (309), Expect = 8e-28
Identities = 188/972 (19%), Positives = 393/972 (40%), Gaps = 147/972 (15%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE------------------A 210
R L E + + E RR++ AE +RA EE +L A
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 211 QKQEVVSDRVERRLQELEREMRTERELVER--RQDQLGLMSL----QLQEALKKQEAKAD 264
Q++ + E++ +E ERE R + E+ RQ +L L QL E +Q A+
Sbjct: 1653 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1712
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL-----TKA 319
+ ++ + Q E ++ LE+EL +R + R+ L ++ ++R ++ +KA
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 320 EGDRKGLQHQVSQISKQ------------------------QSNYQDEQGEDWRFRRGVE 355
+ + S+ SKQ ++ Q + E+ R+ E
Sbjct: 1773 RAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 356 REKQDLEK-----QMSDLRVQLNFSAMASELE-------------EVKRCMERKDKEKAH 397
E+ EK + + L+ + + E E + +R E+ + KA
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 398 LASQVENLTR----ELENGE-------KQQLQMLDRLKEIQNHFDTCEAERKHADLQISE 446
+ ++ L + ELE + +Q+ Q+ + + ++ F+ A + +L++
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
+ +AED + E+ E + L E E+RR + + + Q+S+ + ++ + ALE+
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHS---- 562
V+ L K + + ++ + + LQ + + KR EE+ H+
Sbjct: 2011 ----VERLKAKVEEARRLRERAEQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQ 2059
Query: 563 -KEEKLRDIKSHQADLELEVKNSLDTIHRLESELK------KQSKIQSQMKVEKA-HLEE 614
KE++L+ + + +++ + R E + ++ QS+ +VE+A L++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL---KDLSDLTAQ 671
E +++AQ +A ++++ + +A RA +++A A + K ++ T +
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ-------------NIQEL 718
K++ E+ T + +L+LE HQ+ L D LQ +K + + +++
Sbjct: 2180 QKAQVEQELTTL-RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 719 MKHFKKEKS--EAENHIRTLK---------AESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
M+ K K+ EAEN L+ E E+ +L + RL +
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++ + + L K K Q + + E E L++ +E ++Q L+ ++E +
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQM 2353
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ +E +T + +L++ + + ++ ++ + + + +++
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEE 2412
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET---QRK 944
H+ L Q+ L + E + Q ER + + E+ REK L +E Q K
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 945 DEEMGSLQDRVIALETST--QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKY 1002
EEM ++Q + ET Q L +S+ ++ +E K + E + +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1003 RVRRNSLQHHQD 1014
+R Q Q+
Sbjct: 2533 EQQRQQQQMEQE 2544
Score = 119 bits (299), Expect = 1e-26
Identities = 151/702 (21%), Positives = 313/702 (44%), Gaps = 84/702 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR-LQE 226
+R + + +R + E +R+ + AE +R E E++ ++ E + R + L+E
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 227 LER---EMRTERELVER-RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK-------LR 275
+ER ++ R L ER Q+ + L + A K+ +A+ H A++ K L+
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q ++ +QL E E +RR ++E +R + + R Q+ +AE ++ + Q ++
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 336 QQSNYQD--EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDK 393
Q+ + ++ E RR + +KQ +D +E+E+ K+ E+ +
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-----------AEMEKHKKFAEQTLR 2179
Query: 394 EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
+KA + ++ L +LE + Q+ + + L+ ++ +R + ++ + E+
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 454 ATKQAERYLSELQQ---------SEALKEEAEKRRE------DLKLKAQESIRQWKLKHK 498
+K R +E + L+EEAEK ++ L + AQE+ R +L
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA-- 2297
Query: 499 KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE 558
E L +Q +++ + Q ++E LK + LQQ + L +E R LQE+
Sbjct: 2298 --EEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQE-----QARRLQED 2349
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDT---IHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ + + Q LE E + L+ RL+ + + S+ Q++ + + ++
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 616 IAELKKS------QAQDKAKL---LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
E+ + Q+K L LE+Q D A R L +AE ER K+ + ++
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEAK 2467
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
L Q KS + +T V Q +L T +LQ + ++ + + ++EK
Sbjct: 2468 LL--QLKSEEMQT------------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
++ E + A++ + + + + Q+E+ + + EE + ++E ++ + Q
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
QLE++ + ++E L + E +L++QL LE + + L
Sbjct: 2574 QQLEQQRR----QQEEL--LAEENQRLREQLQLLEEQHRAAL 2609
Score = 106 bits (264), Expect = 1e-22
Identities = 156/791 (19%), Positives = 333/791 (42%), Gaps = 86/791 (10%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLG 246
+++ + + ++ ++E + + ++ + + + E R M E L E+++ +
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 247 LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL 306
+++ AL+KQ A+ H A Q E E +L+Q ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQA----KAQAEREAKELQQRMQ----------------- 1398
Query: 307 HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMS 366
+V A+ ++ +Q ++ Q+ +QS+ + Q + R ER + +E+++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKA-RQAEAAERSRLRIEEEIR 1455
Query: 367 DLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI 426
+R+QL E ++++ +++ L E E Q+ Q + + +
Sbjct: 1456 VVRLQL----------------EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
+ ++ A+++++ + +A ++ +R L L++ EEAE+R L+
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR---LRQAE 1556
Query: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
E RQ ++ + +R+ E EL K ++ +L+ L + LR+E
Sbjct: 1557 VERARQVQVALETAQRSAEA------ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 547 NDVLTKRALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+RA Q+ E ++EE R+++ Q L+ +L RL++E Q K +Q
Sbjct: 1611 E----RRAQQQAEAERAREEAERELERWQ----LKANEALRL--RLQAEEVAQQKSLAQA 1660
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+ EK E E ++ +A+++A + +E + + LA A++ A + L L
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQA--VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 666 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 725
T Q + + + + +L+ E ++ ++L + L V+ + E + + ++
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 726 KSEAENHIRTLKAESLEEKNMAKIH---RGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+S +E + L+AE+ + +A+ R E+ K Q E+ + E +++ +
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 783 QC-------LKDQLEEREKHISIEEEHLRRMEE----ARLQLKDQLLCLETEQESILGVI 831
LK + E K E E LRR+ E R +L++Q + + E L +
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 832 GKEIDAAC---KTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
K D+ K +D++ + + A K +L+ E + R N E
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIRSNAE 1956
Query: 889 KNLR--HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR--- 943
LR Q L + R L +E + +++++ +E R+++ LEE +R
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 944 KDEEMGSLQDR 954
K EE L++R
Sbjct: 2017 KVEEARRLRER 2027
Score = 99.4 bits (246), Expect = 2e-20
Identities = 147/659 (22%), Positives = 294/659 (44%), Gaps = 80/659 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE + QL G ++ R R ++ + R A+++R +EE A++
Sbjct: 2071 QEQSVLDQLRGEAEAAR-------RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
Q + + ++L +E E+E R Q + Q AL++++A AD K
Sbjct: 2124 QAQARAQAQAAAEKLRKE--AEQEAARRAQAE--------QAALRQKQA-ADAEMEKHKK 2172
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH---- 328
QT +K Q+EQEL R L +++ + L +++ L+ + T+A R ++
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 329 ---QVSQISKQQSNYQDEQG----EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
Q+ ++SK ++ + E D + +E+ + KQ+++ +L+ +A
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----- 2287
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E R + +++ A + E + +E + Q +Q RLK EAE
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKE----KMQAVQEATRLK--------AEAELLQQQ 2335
Query: 442 LQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRR--------EDLKLKAQESIRQ 492
+++ E R ++ +Q + L+E Q EAE++R E LKL+ E R
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
+ +R KQ+E + E + +EK L L QQ ++ + L + + +
Sbjct: 2396 QARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKIQSQ--MKVEK 609
++E+L +E KL +KS + + + +T +S L +K S +Q + ++ EK
Sbjct: 2455 LEREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2513
Query: 610 AHLE----EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
A LE +E+A+ ++ + + + + +M++ + L A + + E E + ++L
Sbjct: 2514 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2573
Query: 666 SDLTAQAKSRD----EETATIITQLKLERDVHQREL---KDLTSSLQSVKTKHEQNIQEL 718
L Q + ++ EE + QL+L + H+ L +++T+S Q TK N ++
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS-QVAATKTLPNGRDA 2632
Query: 719 MKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 773
+ E +E E+ R + A+ L+E + + +L++L +Q +EL + E+
Sbjct: 2633 LDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGI--LSAEELQRL-AQGHTTVDELARRED 2687
Score = 62.0 bits (149), Expect = 3e-09
Identities = 121/592 (20%), Positives = 239/592 (40%), Gaps = 79/592 (13%)
Query: 392 DKEKAHLASQVENLTRELENGEKQQLQM---LDRLKEIQNHFDTCEAERKHADLQISELT 448
++E + + L + LE G +++ + + LK+I+ + CE H L
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR----LRLP 1010
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
E A + A+R ++E Q+++A E K L +A++ + AL + S
Sbjct: 1011 LDKEPARECAQR-IAEQQKAQAEVEGLGKGVARLSAEAEKVL------------ALPEPS 1057
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
L + L + +++++ L+++ K ++ V+ EE L + EE+L+
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKL----KTISLVIRGTQGAEEVLRAHEEQLK 1113
Query: 569 DIKSHQADL-ELEV-KNSLD-----------TIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ A L ELE K SL T L EL+ ++ +++ + E
Sbjct: 1114 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1173
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
+ ++ AQ LLE +++ + +R +L + R + L A+ R
Sbjct: 1174 VERWRERVAQ----LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 676 DEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT 735
E+ I + L RE +L +H + ++E + A+ +I
Sbjct: 1230 QEQ----IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF-------AKQYINA 1278
Query: 736 LKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE--NENKKLKLKYQCLKDQLEERE 793
+K L+ ++ QLE + S + + E L+ Y L +
Sbjct: 1279 IKDYELQ----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K IS E LRRMEE +L +Q E E+ + E++AA + ++ ++
Sbjct: 1335 KFIS---ETLRRMEEEE-RLAEQQRAEERERLA-------EVEAALE-------KQRQLA 1376
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESEL 913
+ R E + ++Q EE+ RE + + Q +++L+ L ++ E+E+
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 914 QCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA 965
Q +Q E E+ I E R + + + + + G + + AL + A
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 137 bits (344), Expect = 7e-32
Identities = 187/812 (23%), Positives = 353/812 (43%), Gaps = 119/812 (14%)
Query: 183 NRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--- 239
N L R + +A +R LEE AQ + + +R+ + + + E+ ++ LVE
Sbjct: 1831 NERLRRLAEDEAFQRRRLEE-----QAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1885
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHE---GAIKNKLRQTETEKNQLEQELELSRRLLN 296
R++ Q+ L L+ + +K A E E G I++ T K Q E E R+L
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945
Query: 297 QSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E R +V++ +A RK +V ++ + RR ER
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA----------RRLRER 1995
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
+Q+ +Q+ QL A L+ +EKAH A V+ +EL+ +Q+
Sbjct: 1996 AEQESARQL-----QLAQEAAQKRLQA---------EEKAH-AFAVQQKEQELQQTLQQE 2040
Query: 417 LQMLDRLK-----------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
+LD+L+ E + E E + Q+ E R + A +QA+
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKL------KHKKL-ERALEKQSETVDELTGKN 518
+E L++EAE+ Q ++RQ + KHKK E+ L ++++ ELT
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2160
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Q L+E D K L LQ+ L+ E + +R+ EEEL S ++ ++ +A +E
Sbjct: 2161 LQ-LEETDHQKNLLDEELQR---LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216
Query: 579 LE-----VKNSLDTIHRLESELKKQSKIQSQ-----MKVEKAHLEEEIAE--LKKSQAQD 626
E +++ +T L+ E +K ++ + + ++A ++AE L + +A
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2276
Query: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL 686
+ L E +++++ + ++A+ ++E A++ + D A+ EET L
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2336
Query: 687 KLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ ER QR+L ++++ + +K ++ + +E + F+K+ E + + +
Sbjct: 2337 EAER---QRQL-EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
E+ + + Q ++ +RL E + + E E +KL+ + + L+ + EE + ++++
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ---TVQQ 2449
Query: 801 EHL----RRMEEARLQLKDQLLCLET--EQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
E L + ++++ L KD LL E EQE A + +D V K +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEK----------AKLEQLFQDEVAKAQ--- 2496
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
+ + R + + + Q L ++E R+ + K+ ELQ
Sbjct: 2497 ---QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV-----------RRKQEELQ 2542
Query: 915 CLFQQIERQEQLLDEIH---REKRDLLEETQR 943
L QQ +QE+LL E + RE+ LLEE R
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Score = 131 bits (329), Expect = 4e-30
Identities = 213/1027 (20%), Positives = 410/1027 (39%), Gaps = 139/1027 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSI-------- 87
++ E+ + + R L Q+ + L YRE ++ ++ + EQ
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 88 ---DQLRSQRLL----RNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGI 140
+QLR ++ L G + + ++ EL + L+ P
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA-- 1268
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA- 199
K+ + ++G V + + L + L L+S+ I+ + R + R AE +RA
Sbjct: 1269 KKPKVQSGSESVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-AEQQRAE 1325
Query: 200 -LEELTEKLNEAQKQEVVSD-------RVERRLQELEREMRTE----RELVERRQDQLGL 247
E L E +KQ +++ + ER +EL++ M+ E E Q Q
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 248 MSLQLQEALKKQEA----KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRE 303
+ +LQ+ + EA KA + E A +++LR E E + +LE + R +EG +
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 304 TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEK 363
L + EE Q +A+ + + L+ QV S+++ + E + REKQ +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 364 QMSDLRVQLNFSAMASELEEVKRCME--------------RKDKEKAHLASQVENLTREL 409
+ +LR+Q + EV+R + ++A A + L R L
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ Q+ + + E R+ A+ ++ A +A + + QQ
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 470 ALKEEAEKRREDLKLKA-------QESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ EAEK++E+ + +A ++++RQ +L ++LE+ + T + +++
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684
Query: 523 K-----EKDELKTQL----YAALQ---------------QIENLRKELNDVLTKRALQEE 558
+ E+ E + QL A LQ ++ +R E+ +L +A EE
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI-QSQMKVEKAHLEEEIA 617
E S EK + +A E+ + L E K+Q ++ + ++A E +A
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
E + + E + ++K+ A L +LAE+E ++ + L + AQ K+ E
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERL-RRLAEDEAFQR---RRLEEQAAQHKADIE 1860
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE---KSEAE---N 731
E + QL+ D K L + + E+ I L F+K K+E E
Sbjct: 1861 ER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-----------ENENKKLKL 780
IR+ ++L K A++ + +L ++ +R E + + K
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 781 KYQCLKDQLEE-REKHISIEEEHLRRMEEAR-----------------LQLKDQLLCLET 822
+ + LK ++EE R E+E R+++ A+ +Q K+Q L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 823 EQE-SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+QE S+L + E +AA + + + E+ +V R A+S+ +++ E L
Sbjct: 2038 QQEQSVLDQLRGEAEAARR--AAEEAEEARV---------QAEREAAQSRRQVE-EAERL 2085
Query: 882 KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
K+ + R Q ++LR E + + Q RQ+Q D + + E+T
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 942 QRKDEEM 948
R+ ++
Sbjct: 2146 LRQKAQV 2152
Score = 123 bits (309), Expect = 8e-28
Identities = 188/972 (19%), Positives = 393/972 (40%), Gaps = 147/972 (15%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE------------------A 210
R L E + + E RR++ AE +RA EE +L A
Sbjct: 1562 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620
Query: 211 QKQEVVSDRVERRLQELEREMRTERELVER--RQDQLGLMSL----QLQEALKKQEAKAD 264
Q++ + E++ +E ERE R + E+ RQ +L L QL E +Q A+
Sbjct: 1621 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1680
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL-----TKA 319
+ ++ + Q E ++ LE+EL +R + R+ L ++ ++R ++ +KA
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1740
Query: 320 EGDRKGLQHQVSQISKQ------------------------QSNYQDEQGEDWRFRRGVE 355
+ + S+ SKQ ++ Q + E+ R+ E
Sbjct: 1741 RAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 356 REKQDLEK-----QMSDLRVQLNFSAMASELE-------------EVKRCMERKDKEKAH 397
E+ EK + + L+ + + E E + +R E+ + KA
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 398 LASQVENLTR----ELENGE-------KQQLQMLDRLKEIQNHFDTCEAERKHADLQISE 446
+ ++ L + ELE + +Q+ Q+ + + ++ F+ A + +L++
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
+ +AED + E+ E + L E E+RR + + + Q+S+ + ++ + ALE+
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHS---- 562
V+ L K + + ++ + + LQ + + KR EE+ H+
Sbjct: 1979 ----VERLKAKVEEARRLRERAEQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQ 2027
Query: 563 -KEEKLRDIKSHQADLELEVKNSLDTIHRLESELK------KQSKIQSQMKVEKA-HLEE 614
KE++L+ + + +++ + R E + ++ QS+ +VE+A L++
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL---KDLSDLTAQ 671
E +++AQ +A ++++ + +A RA +++A A + K ++ T +
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ-------------NIQEL 718
K++ E+ T + +L+LE HQ+ L D LQ +K + + +++
Sbjct: 2148 QKAQVEQELTTL-RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 719 MKHFKKEKS--EAENHIRTLK---------AESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
M+ K K+ EAEN L+ E E+ +L + RL +
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++ + + L K K Q + + E E L++ +E ++Q L+ ++E +
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQM 2321
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ +E +T + +L++ + + ++ ++ + + + +++
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEE 2380
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET---QRK 944
H+ L Q+ L + E + Q ER + + E+ REK L +E Q K
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 945 DEEMGSLQDRVIALETST--QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKY 1002
EEM ++Q + ET Q L +S+ ++ +E K + E + +
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 1003 RVRRNSLQHHQD 1014
+R Q Q+
Sbjct: 2501 EQQRQQQQMEQE 2512
Score = 119 bits (299), Expect = 1e-26
Identities = 151/702 (21%), Positives = 313/702 (44%), Gaps = 84/702 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR-LQE 226
+R + + +R + E +R+ + AE +R E E++ ++ E + R + L+E
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 227 LER---EMRTERELVER-RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK-------LR 275
+ER ++ R L ER Q+ + L + A K+ +A+ H A++ K L+
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q ++ +QL E E +RR ++E +R + + R Q+ +AE ++ + Q ++
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 336 QQSNYQD--EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDK 393
Q+ + ++ E RR + +KQ +D +E+E+ K+ E+ +
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-----------AEMEKHKKFAEQTLR 2147
Query: 394 EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
+KA + ++ L +LE + Q+ + + L+ ++ +R + ++ + E+
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 454 ATKQAERYLSELQQ---------SEALKEEAEKRRE------DLKLKAQESIRQWKLKHK 498
+K R +E + L+EEAEK ++ L + AQE+ R +L
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA-- 2265
Query: 499 KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE 558
E L +Q +++ + Q ++E LK + LQQ + L +E R LQE+
Sbjct: 2266 --EEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQE-----QARRLQED 2317
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDT---IHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ + + Q LE E + L+ RL+ + + S+ Q++ + + ++
Sbjct: 2318 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2377
Query: 616 IAELKKS------QAQDKAKL---LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
E+ + Q+K L LE+Q D A R L +AE ER K+ + ++
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEAK 2435
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
L Q KS + +T V Q +L T +LQ + ++ + + ++EK
Sbjct: 2436 LL--QLKSEEMQT------------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
++ E + A++ + + + + Q+E+ + + EE + ++E ++ + Q
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
QLE++ + ++E L + E +L++QL LE + + L
Sbjct: 2542 QQLEQQRR----QQEEL--LAEENQRLREQLQLLEEQHRAAL 2577
Score = 106 bits (264), Expect = 1e-22
Identities = 156/791 (19%), Positives = 333/791 (42%), Gaps = 86/791 (10%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLG 246
+++ + + ++ ++E + + ++ + + + E R M E L E+++ +
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327
Query: 247 LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL 306
+++ AL+KQ A+ H A Q E E +L+Q ++
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQA----KAQAEREAKELQQRMQ----------------- 1366
Query: 307 HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMS 366
+V A+ ++ +Q ++ Q+ +QS+ + Q + R ER + +E+++
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKA-RQAEAAERSRLRIEEEIR 1423
Query: 367 DLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI 426
+R+QL E ++++ +++ L E E Q+ Q + + +
Sbjct: 1424 VVRLQL----------------EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
+ ++ A+++++ + +A ++ +R L L++ EEAE+R L+
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR---LRQAE 1524
Query: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
E RQ ++ + +R+ E EL K ++ +L+ L + LR+E
Sbjct: 1525 VERARQVQVALETAQRSAEA------ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 547 NDVLTKRALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+RA Q+ E ++EE R+++ Q L+ +L RL++E Q K +Q
Sbjct: 1579 E----RRAQQQAEAERAREEAERELERWQ----LKANEALRL--RLQAEEVAQQKSLAQA 1628
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+ EK E E ++ +A+++A + +E + + LA A++ A + L L
Sbjct: 1629 EAEKQKEEAEREARRRGKAEEQA--VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 666 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 725
T Q + + + + +L+ E ++ ++L + L V+ + E + + ++
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746
Query: 726 KSEAENHIRTLKAESLEEKNMAKIH---RGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+S +E + L+AE+ + +A+ R E+ K Q E+ + E +++ +
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806
Query: 783 QC-------LKDQLEEREKHISIEEEHLRRMEE----ARLQLKDQLLCLETEQESILGVI 831
LK + E K E E LRR+ E R +L++Q + + E L +
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Query: 832 GKEIDAAC---KTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
K D+ K +D++ + + A K +L+ E + R N E
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIRSNAE 1924
Query: 889 KNLR--HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR--- 943
LR Q L + R L +E + +++++ +E R+++ LEE +R
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 944 KDEEMGSLQDR 954
K EE L++R
Sbjct: 1985 KVEEARRLRER 1995
Score = 99.4 bits (246), Expect = 2e-20
Identities = 147/659 (22%), Positives = 294/659 (44%), Gaps = 80/659 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE + QL G ++ R R ++ + R A+++R +EE A++
Sbjct: 2039 QEQSVLDQLRGEAEAAR-------RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
Q + + ++L +E E+E R Q + Q AL++++A AD K
Sbjct: 2092 QAQARAQAQAAAEKLRKE--AEQEAARRAQAE--------QAALRQKQA-ADAEMEKHKK 2140
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH---- 328
QT +K Q+EQEL R L +++ + L +++ L+ + T+A R ++
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 329 ---QVSQISKQQSNYQDEQG----EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
Q+ ++SK ++ + E D + +E+ + KQ+++ +L+ +A
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----- 2255
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E R + +++ A + E + +E + Q +Q RLK EAE
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKE----KMQAVQEATRLK--------AEAELLQQQ 2303
Query: 442 LQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRR--------EDLKLKAQESIRQ 492
+++ E R ++ +Q + L+E Q EAE++R E LKL+ E R
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
+ +R KQ+E + E + +EK L L QQ ++ + L + + +
Sbjct: 2364 QARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKIQSQ--MKVEK 609
++E+L +E KL +KS + + + +T +S L +K S +Q + ++ EK
Sbjct: 2423 LEREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2481
Query: 610 AHLE----EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
A LE +E+A+ ++ + + + + +M++ + L A + + E E + ++L
Sbjct: 2482 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2541
Query: 666 SDLTAQAKSRD----EETATIITQLKLERDVHQREL---KDLTSSLQSVKTKHEQNIQEL 718
L Q + ++ EE + QL+L + H+ L +++T+S Q TK N ++
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS-QVAATKTLPNGRDA 2600
Query: 719 MKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 773
+ E +E E+ R + A+ L+E + + +L++L +Q +EL + E+
Sbjct: 2601 LDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGI--LSAEELQRL-AQGHTTVDELARRED 2655
Score = 62.0 bits (149), Expect = 3e-09
Identities = 121/592 (20%), Positives = 239/592 (40%), Gaps = 79/592 (13%)
Query: 392 DKEKAHLASQVENLTRELENGEKQQLQM---LDRLKEIQNHFDTCEAERKHADLQISELT 448
++E + + L + LE G +++ + + LK+I+ + CE H L
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR----LRLP 978
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
E A + A+R ++E Q+++A E K L +A++ + AL + S
Sbjct: 979 LDKEPARECAQR-IAEQQKAQAEVEGLGKGVARLSAEAEKVL------------ALPEPS 1025
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
L + L + +++++ L+++ K ++ V+ EE L + EE+L+
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKL----KTISLVIRGTQGAEEVLRAHEEQLK 1081
Query: 569 DIKSHQADL-ELEV-KNSLD-----------TIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ A L ELE K SL T L EL+ ++ +++ + E
Sbjct: 1082 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1141
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
+ ++ AQ LLE +++ + +R +L + R + L A+ R
Sbjct: 1142 VERWRERVAQ----LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197
Query: 676 DEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT 735
E+ I + L RE +L +H + ++E + A+ +I
Sbjct: 1198 QEQ----IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF-------AKQYINA 1246
Query: 736 LKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE--NENKKLKLKYQCLKDQLEERE 793
+K L+ ++ QLE + S + + E L+ Y L +
Sbjct: 1247 IKDYELQ----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1302
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K IS E LRRMEE +L +Q E E+ + E++AA + ++ ++
Sbjct: 1303 KFIS---ETLRRMEEEE-RLAEQQRAEERERLA-------EVEAALE-------KQRQLA 1344
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESEL 913
+ R E + ++Q EE+ RE + + Q +++L+ L ++ E+E+
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401
Query: 914 QCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA 965
Q +Q E E+ I E R + + + + + G + + AL + A
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 137 bits (344), Expect = 7e-32
Identities = 187/812 (23%), Positives = 353/812 (43%), Gaps = 119/812 (14%)
Query: 183 NRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVE--- 239
N L R + +A +R LEE AQ + + +R+ + + + E+ ++ LVE
Sbjct: 2000 NERLRRLAEDEAFQRRRLEE-----QAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 2054
Query: 240 RRQDQLGLMSLQLQEALKKQEAKADEHE---GAIKNKLRQTETEKNQLEQELELSRRLLN 296
R++ Q+ L L+ + +K A E E G I++ T K Q E E R+L
Sbjct: 2055 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114
Query: 297 QSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER 356
+ E R +V++ +A RK +V ++ + RR ER
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA----------RRLRER 2164
Query: 357 EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQ 416
+Q+ +Q+ QL A L+ +EKAH A V+ +EL+ +Q+
Sbjct: 2165 AEQESARQL-----QLAQEAAQKRLQA---------EEKAH-AFAVQQKEQELQQTLQQE 2209
Query: 417 LQMLDRLK-----------EIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSEL 465
+LD+L+ E + E E + Q+ E R + A +QA+
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKL------KHKKL-ERALEKQSETVDELTGKN 518
+E L++EAE+ Q ++RQ + KHKK E+ L ++++ ELT
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2329
Query: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Q L+E D K L LQ+ L+ E + +R+ EEEL S ++ ++ +A +E
Sbjct: 2330 LQ-LEETDHQKNLLDEELQR---LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385
Query: 579 LE-----VKNSLDTIHRLESELKKQSKIQSQ-----MKVEKAHLEEEIAE--LKKSQAQD 626
E +++ +T L+ E +K ++ + + ++A ++AE L + +A
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALA 2445
Query: 627 KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQL 686
+ L E +++++ + ++A+ ++E A++ + D A+ EET L
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2505
Query: 687 KLERDVHQRELKDLTSSLQSVK------TKHEQNIQELMKHFKKEKSEAENHIRTLKAES 740
+ ER QR+L ++++ + +K ++ + +E + F+K+ E + + +
Sbjct: 2506 EAER---QRQL-EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561
Query: 741 LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE 800
E+ + + Q ++ +RL E + + E E +KL+ + + L+ + EE + ++++
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ---TVQQ 2618
Query: 801 EHL----RRMEEARLQLKDQLLCLET--EQESILGVIGKEIDAACKTFSKDSVEKLKVFS 854
E L + ++++ L KD LL E EQE A + +D V K +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEK----------AKLEQLFQDEVAKAQ--- 2665
Query: 855 SGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ 914
+ + R + + + Q L ++E R+ + K+ ELQ
Sbjct: 2666 ---QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV-----------RRKQEELQ 2711
Query: 915 CLFQQIERQEQLLDEIH---REKRDLLEETQR 943
L QQ +QE+LL E + RE+ LLEE R
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Score = 131 bits (329), Expect = 4e-30
Identities = 213/1027 (20%), Positives = 410/1027 (39%), Gaps = 139/1027 (13%)
Query: 36 EVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSI-------- 87
++ E+ + + R L Q+ + L YRE ++ ++ + EQ
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 88 ---DQLRSQRLL----RNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGI 140
+QLR ++ L G + + ++ EL + L+ P
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA-- 1437
Query: 141 KRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRA- 199
K+ + ++G V + + L + L L+S+ I+ + R + R AE +RA
Sbjct: 1438 KKPKVQSGSESVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL-AEQQRAE 1494
Query: 200 -LEELTEKLNEAQKQEVVSD-------RVERRLQELEREMRTE----RELVERRQDQLGL 247
E L E +KQ +++ + ER +EL++ M+ E E Q Q
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 248 MSLQLQEALKKQEA----KADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRE 303
+ +LQ+ + EA KA + E A +++LR E E + +LE + R +EG +
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 304 TLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEK 363
L + EE Q +A+ + + L+ QV S+++ + E + REKQ +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 364 QMSDLRVQLNFSAMASELEEVKRCME--------------RKDKEKAHLASQVENLTREL 409
+ +LR+Q + EV+R + ++A A + L R L
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 410 ENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSE 469
+ Q+ + + E R+ A+ ++ A +A + + QQ
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 470 ALKEEAEKRREDLKLKA-------QESIRQWKLKHKKLERALEKQSETVDELTGKNNQIL 522
+ EAEK++E+ + +A ++++RQ +L ++LE+ + T + +++
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853
Query: 523 K-----EKDELKTQL----YAALQ---------------QIENLRKELNDVLTKRALQEE 558
+ E+ E + QL A LQ ++ +R E+ +L +A EE
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKI-QSQMKVEKAHLEEEIA 617
E S EK + +A E+ + L E K+Q ++ + ++A E +A
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 618 ELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDE 677
E + + E + ++K+ A L +LAE+E ++ + L + AQ K+ E
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERL-RRLAEDEAFQR---RRLEEQAAQHKADIE 2029
Query: 678 ETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE---KSEAE---N 731
E + QL+ D K L + + E+ I L F+K K+E E
Sbjct: 2030 ER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 732 HIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-----------ENENKKLKL 780
IR+ ++L K A++ + +L ++ +R E + + K
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 781 KYQCLKDQLEE-REKHISIEEEHLRRMEEAR-----------------LQLKDQLLCLET 822
+ + LK ++EE R E+E R+++ A+ +Q K+Q L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 823 EQE-SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEEL 881
+QE S+L + E +AA + + + E+ +V R A+S+ +++ E L
Sbjct: 2207 QQEQSVLDQLRGEAEAARR--AAEEAEEARV---------QAEREAAQSRRQVE-EAERL 2254
Query: 882 KERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
K+ + R Q ++LR E + + Q RQ+Q D + + E+T
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 942 QRKDEEM 948
R+ ++
Sbjct: 2315 LRQKAQV 2321
Score = 123 bits (309), Expect = 8e-28
Identities = 188/972 (19%), Positives = 393/972 (40%), Gaps = 147/972 (15%)
Query: 169 RDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNE------------------A 210
R L E + + E RR++ AE +RA EE +L A
Sbjct: 1731 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789
Query: 211 QKQEVVSDRVERRLQELEREMRTERELVER--RQDQLGLMSL----QLQEALKKQEAKAD 264
Q++ + E++ +E ERE R + E+ RQ +L L QL E +Q A+
Sbjct: 1790 QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849
Query: 265 EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL-----TKA 319
+ ++ + Q E ++ LE+EL +R + R+ L ++ ++R ++ +KA
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1909
Query: 320 EGDRKGLQHQVSQISKQ------------------------QSNYQDEQGEDWRFRRGVE 355
+ + S+ SKQ ++ Q + E+ R+ E
Sbjct: 1910 RAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 356 REKQDLEK-----QMSDLRVQLNFSAMASELE-------------EVKRCMERKDKEKAH 397
E+ EK + + L+ + + E E + +R E+ + KA
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 398 LASQVENLTR----ELENGE-------KQQLQMLDRLKEIQNHFDTCEAERKHADLQISE 446
+ ++ L + ELE + +Q+ Q+ + + ++ F+ A + +L++
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 447 LTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK 506
+ +AED + E+ E + L E E+RR + + + Q+S+ + ++ + ALE+
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 507 QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHS---- 562
V+ L K + + ++ + + LQ + + KR EE+ H+
Sbjct: 2148 ----VERLKAKVEEARRLRERAEQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQ 2196
Query: 563 -KEEKLRDIKSHQADLELEVKNSLDTIHRLESELK------KQSKIQSQMKVEKA-HLEE 614
KE++L+ + + +++ + R E + ++ QS+ +VE+A L++
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVL---KDLSDLTAQ 671
E +++AQ +A ++++ + +A RA +++A A + K ++ T +
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ-------------NIQEL 718
K++ E+ T + +L+LE HQ+ L D LQ +K + + +++
Sbjct: 2317 QKAQVEQELTTL-RLQLEETDHQKNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 719 MKHFKKEKS--EAENHIRTLK---------AESLEEKNMAKIHRGQLEKLKSQCDRLTEE 767
M+ K K+ EAEN L+ E E+ +L + RL +
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 768 LTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESI 827
++ + + L K K Q + + E E L++ +E ++Q L+ ++E +
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQM 2490
Query: 828 LGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENR 887
+ +E +T + +L++ + + ++ ++ + + + +++
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEE 2549
Query: 888 EKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET---QRK 944
H+ L Q+ L + E + Q ER + + E+ REK L +E Q K
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 945 DEEMGSLQDRVIALETST--QVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKY 1002
EEM ++Q + ET Q L +S+ ++ +E K + E + +
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 1003 RVRRNSLQHHQD 1014
+R Q Q+
Sbjct: 2670 EQQRQQQQMEQE 2681
Score = 119 bits (299), Expect = 1e-26
Identities = 151/702 (21%), Positives = 313/702 (44%), Gaps = 84/702 (11%)
Query: 168 LRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR-LQE 226
+R + + +R + E +R+ + AE +R E E++ ++ E + R + L+E
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 227 LER---EMRTERELVER-RQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK-------LR 275
+ER ++ R L ER Q+ + L + A K+ +A+ H A++ K L+
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 276 QTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISK 335
Q ++ +QL E E +RR ++E +R + + R Q+ +AE ++ + Q ++
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 336 QQSNYQD--EQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDK 393
Q+ + ++ E RR + +KQ +D +E+E+ K+ E+ +
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD-----------AEMEKHKKFAEQTLR 2316
Query: 394 EKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAED 453
+KA + ++ L +LE + Q+ + + L+ ++ +R + ++ + E+
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 454 ATKQAERYLSELQQ---------SEALKEEAEKRRE------DLKLKAQESIRQWKLKHK 498
+K R +E + L+EEAEK ++ L + AQE+ R +L
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA-- 2434
Query: 499 KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE 558
E L +Q +++ + Q ++E LK + LQQ + L +E R LQE+
Sbjct: 2435 --EEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQE-----QARRLQED 2486
Query: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDT---IHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ + + Q LE E + L+ RL+ + + S+ Q++ + + ++
Sbjct: 2487 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2546
Query: 616 IAELKKS------QAQDKAKL---LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLS 666
E+ + Q+K L LE+Q D A R L +AE ER K+ + ++
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEAK 2604
Query: 667 DLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEK 726
L Q KS + +T V Q +L T +LQ + ++ + + ++EK
Sbjct: 2605 LL--QLKSEEMQT------------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLK 786
++ E + A++ + + + + Q+E+ + + EE + ++E ++ + Q
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710
Query: 787 DQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESIL 828
QLE++ + ++E L + E +L++QL LE + + L
Sbjct: 2711 QQLEQQRR----QQEEL--LAEENQRLREQLQLLEEQHRAAL 2746
Score = 106 bits (264), Expect = 1e-22
Identities = 156/791 (19%), Positives = 333/791 (42%), Gaps = 86/791 (10%)
Query: 187 SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLG 246
+++ + + ++ ++E + + ++ + + + E R M E L E+++ +
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496
Query: 247 LMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLL 306
+++ AL+KQ A+ H A Q E E +L+Q ++
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQA----KAQAEREAKELQQRMQ----------------- 1535
Query: 307 HQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMS 366
+V A+ ++ +Q ++ Q+ +QS+ + Q + R ER + +E+++
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQL--RQSSEAEIQAKA-RQAEAAERSRLRIEEEIR 1592
Query: 367 DLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEI 426
+R+QL E ++++ +++ L E E Q+ Q + + +
Sbjct: 1593 VVRLQL----------------EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 427 QNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
+ ++ A+++++ + +A ++ +R L L++ EEAE+R L+
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR---LRQAE 1693
Query: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
E RQ ++ + +R+ E EL K ++ +L+ L + LR+E
Sbjct: 1694 VERARQVQVALETAQRSAEA------ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 547 NDVLTKRALQEEEL-HSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQM 605
+RA Q+ E ++EE R+++ Q L+ +L RL++E Q K +Q
Sbjct: 1748 E----RRAQQQAEAERAREEAERELERWQ----LKANEALRL--RLQAEEVAQQKSLAQA 1797
Query: 606 KVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
+ EK E E ++ +A+++A + +E + + LA A++ A + L L
Sbjct: 1798 EAEKQKEEAEREARRRGKAEEQA--VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 666 SDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKE 725
T Q + + + + +L+ E ++ ++L + L V+ + E + + ++
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915
Query: 726 KSEAENHIRTLKAESLEEKNMAKIH---RGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
+S +E + L+AE+ + +A+ R E+ K Q E+ + E +++ +
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975
Query: 783 QC-------LKDQLEEREKHISIEEEHLRRMEE----ARLQLKDQLLCLETEQESILGVI 831
LK + E K E E LRR+ E R +L++Q + + E L +
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 832 GKEIDAAC---KTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE 888
K D+ K +D++ + + A K +L+ E + R N E
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE--LELGRIRSNAE 2093
Query: 889 KNLR--HQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQR--- 943
LR Q L + R L +E + +++++ +E R+++ LEE +R
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 944 KDEEMGSLQDR 954
K EE L++R
Sbjct: 2154 KVEEARRLRER 2164
Score = 99.4 bits (246), Expect = 2e-20
Identities = 147/659 (22%), Positives = 294/659 (44%), Gaps = 80/659 (12%)
Query: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
QE + QL G ++ R R ++ + R A+++R +EE A++
Sbjct: 2208 QEQSVLDQLRGEAEAAR-------RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 213 QEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKN 272
Q + + ++L +E E+E R Q + Q AL++++A AD K
Sbjct: 2261 QAQARAQAQAAAEKLRKE--AEQEAARRAQAE--------QAALRQKQA-ADAEMEKHKK 2309
Query: 273 KLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQH---- 328
QT +K Q+EQEL R L +++ + L +++ L+ + T+A R ++
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 329 ---QVSQISKQQSNYQDEQG----EDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASEL 381
Q+ ++SK ++ + E D + +E+ + KQ+++ +L+ +A
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----- 2424
Query: 382 EEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHAD 441
+E R + +++ A + E + +E + Q +Q RLK EAE
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKE----KMQAVQEATRLK--------AEAELLQQQ 2472
Query: 442 LQIS-ELTRHAEDATKQAERYLSELQQSEALKEEAEKRR--------EDLKLKAQESIRQ 492
+++ E R ++ +Q + L+E Q EAE++R E LKL+ E R
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532
Query: 493 WKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK 552
+ +R KQ+E + E + +EK L L QQ ++ + L + + +
Sbjct: 2533 QARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 553 RALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESEL-KKQSKIQSQ--MKVEK 609
++E+L +E KL +KS + + + +T +S L +K S +Q + ++ EK
Sbjct: 2592 LEREKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650
Query: 610 AHLE----EEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDL 665
A LE +E+A+ ++ + + + + +M++ + L A + + E E + ++L
Sbjct: 2651 AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710
Query: 666 SDLTAQAKSRD----EETATIITQLKLERDVHQREL---KDLTSSLQSVKTKHEQNIQEL 718
L Q + ++ EE + QL+L + H+ L +++T+S Q TK N ++
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS-QVAATKTLPNGRDA 2769
Query: 719 MKHFKKEKSEAENHI----RTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN 773
+ E +E E+ R + A+ L+E + + +L++L +Q +EL + E+
Sbjct: 2770 LDGPAAE-AEPEHSFDGLRRKVSAQRLQEAGI--LSAEELQRL-AQGHTTVDELARRED 2824
Score = 62.0 bits (149), Expect = 3e-09
Identities = 121/592 (20%), Positives = 239/592 (40%), Gaps = 79/592 (13%)
Query: 392 DKEKAHLASQVENLTRELENGEKQQLQM---LDRLKEIQNHFDTCEAERKHADLQISELT 448
++E + + L + LE G +++ + + LK+I+ + CE H L
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR----LRLP 1147
Query: 449 RHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS 508
E A + A+R ++E Q+++A E K L +A++ + AL + S
Sbjct: 1148 LDKEPARECAQR-IAEQQKAQAEVEGLGKGVARLSAEAEKVL------------ALPEPS 1194
Query: 509 ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
L + L + +++++ L+++ K ++ V+ EE L + EE+L+
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKL----KTISLVIRGTQGAEEVLRAHEEQLK 1250
Query: 569 DIKSHQADL-ELEV-KNSLD-----------TIHRLESELKKQSKIQSQMKVEKAHLEEE 615
+ ++ A L ELE K SL T L EL+ ++ +++ + E
Sbjct: 1251 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1310
Query: 616 IAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSR 675
+ ++ AQ LLE +++ + +R +L + R + L A+ R
Sbjct: 1311 VERWRERVAQ----LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1366
Query: 676 DEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRT 735
E+ I + L RE +L +H + ++E + A+ +I
Sbjct: 1367 QEQ----IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF-------AKQYINA 1415
Query: 736 LKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNE--NENKKLKLKYQCLKDQLEERE 793
+K L+ ++ QLE + S + + E L+ Y L +
Sbjct: 1416 IKDYELQ----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1471
Query: 794 KHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVF 853
K IS E LRRMEE +L +Q E E+ + E++AA + ++ ++
Sbjct: 1472 KFIS---ETLRRMEEEE-RLAEQQRAEERERLA-------EVEAALE-------KQRQLA 1513
Query: 854 SSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESEL 913
+ R E + ++Q EE+ RE + + Q +++L+ L ++ E+E+
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570
Query: 914 QCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA 965
Q +Q E E+ I E R + + + + + G + + AL + A
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.331
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,692,781
Number of Sequences: 37866
Number of extensions: 1768382
Number of successful extensions: 36014
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 1469
Number of HSP's that attempted gapping in prelim test: 9415
Number of HSP's gapped (non-prelim): 10453
length of query: 1094
length of database: 18,247,518
effective HSP length: 113
effective length of query: 981
effective length of database: 13,968,660
effective search space: 13703255460
effective search space used: 13703255460
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.