Guide to the Human Genome
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Search of human proteins with 63252888

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63252888 prolyl 4-hydroxylase, alpha I subunit isoform 2
precursor [Homo sapiens]
         (534 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217272849 prolyl 4-hydroxylase, alpha I subunit isoform 2 pre...  1089   0.0  
gi|63252888 prolyl 4-hydroxylase, alpha I subunit isoform 2 prec...  1089   0.0  
gi|63252886 prolyl 4-hydroxylase, alpha I subunit isoform 1 prec...  1070   0.0  
gi|217272851 prolyl 4-hydroxylase, alpha I subunit isoform 3 pre...  1019   0.0  
gi|217272863 prolyl 4-hydroxylase, alpha II subunit isoform 1 pr...   702   0.0  
gi|4758868 prolyl 4-hydroxylase, alpha II subunit isoform 1 prec...   702   0.0  
gi|217272861 prolyl 4-hydroxylase, alpha II subunit isoform 2 pr...   681   0.0  
gi|63252893 prolyl 4-hydroxylase, alpha II subunit isoform 2 pre...   681   0.0  
gi|63252891 prolyl 4-hydroxylase, alpha II subunit isoform 2 pre...   681   0.0  
gi|33589818 prolyl 4-hydroxylase, alpha III subunit precursor [H...   323   3e-88
gi|29570771 hypoxia-inducible factor prolyl 4-hydroxylase isofor...    75   2e-13
gi|64085083 hypoxia-inducible factor prolyl 4-hydroxylase isofor...    57   3e-08
gi|216548091 leucine zipper protein 1 [Homo sapiens]                   39   0.016
gi|216548085 leucine zipper protein 1 [Homo sapiens]                   39   0.016
gi|197313662 leprecan-like 1 isoform b [Homo sapiens]                  34   0.38 
gi|27764882 leprecan-like 1 isoform a [Homo sapiens]                   34   0.38 
gi|64276486 serologically defined colon cancer antigen 10 [Homo ...    33   0.50 
gi|4826870 nucleobindin 2 [Homo sapiens]                               32   1.1  
gi|238859557 regulatory factor X1 [Homo sapiens]                       32   1.5  
gi|10337581 type I hair keratin 3B [Homo sapiens]                      31   3.2  
gi|186928835 leprecan 1 isoform 1 [Homo sapiens]                       31   3.2  
gi|226371643 leprecan 1 isoform 2 [Homo sapiens]                       31   3.2  
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     31   3.2  
gi|221316624 dystonin isoform 4 [Homo sapiens]                         30   4.2  
gi|221316622 dystonin isoform 3 [Homo sapiens]                         30   4.2  
gi|221316618 dystonin isoform 2 [Homo sapiens]                         30   4.2  
gi|34577047 dystonin isoform 1 [Homo sapiens]                          30   4.2  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]              30   4.2  
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             30   4.2  
gi|5453629 dynactin 2 [Homo sapiens]                                   30   7.2  

>gi|217272849 prolyl 4-hydroxylase, alpha I subunit isoform 2
           precursor [Homo sapiens]
          Length = 534

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
Sbjct: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
           EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
Sbjct: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
Sbjct: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
Sbjct: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300
           ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
Sbjct: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300

Query: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360
           TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
Sbjct: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360

Query: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420
           RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
Sbjct: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420

Query: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480
           GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
Sbjct: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480

Query: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Sbjct: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534


>gi|63252888 prolyl 4-hydroxylase, alpha I subunit isoform 2
           precursor [Homo sapiens]
          Length = 534

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
Sbjct: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
           EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
Sbjct: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
Sbjct: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
Sbjct: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300
           ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
Sbjct: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300

Query: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360
           TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
Sbjct: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360

Query: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420
           RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
Sbjct: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420

Query: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480
           GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
Sbjct: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480

Query: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Sbjct: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534


>gi|63252886 prolyl 4-hydroxylase, alpha I subunit isoform 1
           precursor [Homo sapiens]
          Length = 534

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 524/534 (98%), Positives = 527/534 (98%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
Sbjct: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
           EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
Sbjct: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
Sbjct: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
Sbjct: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300
           ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
Sbjct: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300

Query: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360
           TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
Sbjct: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360

Query: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420
            RAT+ +P TG L T  YR+SKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
Sbjct: 361 SRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420

Query: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480
           GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
Sbjct: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480

Query: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Sbjct: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534


>gi|217272851 prolyl 4-hydroxylase, alpha I subunit isoform 3
           precursor [Homo sapiens]
          Length = 516

 Score = 1019 bits (2636), Expect = 0.0
 Identities = 506/534 (94%), Positives = 509/534 (95%), Gaps = 18/534 (3%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
Sbjct: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
           EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
Sbjct: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
Sbjct: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
Sbjct: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300
           ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
Sbjct: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM 300

Query: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360
           TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
Sbjct: 301 TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL 360

Query: 361 RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY 420
            RAT+ +P TG L T  YR+SKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQ    
Sbjct: 361 SRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQ---- 416

Query: 421 GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 480
                         KDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
Sbjct: 417 --------------KDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG 462

Query: 481 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
Sbjct: 463 TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 516


>gi|217272863 prolyl 4-hydroxylase, alpha II subunit isoform 1
           precursor [Homo sapiens]
          Length = 535

 Score =  702 bits (1812), Expect = 0.0
 Identities = 334/537 (62%), Positives = 421/537 (78%), Gaps = 14/537 (2%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           M W+    G+L   S     FFTSIG MTDLI+ EK+LV SLK+YI  EE KL +IK WA
Sbjct: 10  MAWF----GVL---SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWA 62

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
            K++ LTS +  D EG++ HPVNA+KL+KRLNT+W  LE+LVL+D + GFI+NL++QRQ+
Sbjct: 63  NKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQF 122

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FP DED++GAAKAL+RLQDTY LD  TIS+G LPG K+++ L+ +DCF +G+ AY E DY
Sbjct: 123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDY 182

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHT LWMEQ L+QLD GE +T  K  VLDYLSYAV+Q GDL +AL LT++LL LDP H+R
Sbjct: 183 YHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHER 242

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV---AVDYLPERQKYEMLCRGEG 297
           A GNL+YFE ++ +E++  K+ ++    +  TP+  G+    VDYLPER  YE LCRGEG
Sbjct: 243 AGGNLRYFEQLLEEERE--KTLTNQTEAELATPE--GIYERPVDYLPERDVYESLCRGEG 298

Query: 298 IKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAK 357
           +K+TPRRQK+LFCRYH GNR P+ ++AP K+EDEWD P I+R++D++SD EIE +K++AK
Sbjct: 299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

Query: 358 PRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQV 417
           P+L RAT+ +P TG L    YR+SKS+WL   ++PVV+R+N R+Q +TGL V TAE LQV
Sbjct: 359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQV 418

Query: 418 ANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477
           ANYGVGGQYEPHFDF+R DE D FK LGTGNR+AT+L YMSDV AGGATVFP++GA++WP
Sbjct: 419 ANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWP 478

Query: 478 KKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           KKGTAVFWYNL  SGEGDY TRHAACPVLVG KWVSNKW HERGQEF RPC  +E++
Sbjct: 479 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD 535


>gi|4758868 prolyl 4-hydroxylase, alpha II subunit isoform 1
           precursor [Homo sapiens]
          Length = 535

 Score =  702 bits (1812), Expect = 0.0
 Identities = 334/537 (62%), Positives = 421/537 (78%), Gaps = 14/537 (2%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           M W+    G+L   S     FFTSIG MTDLI+ EK+LV SLK+YI  EE KL +IK WA
Sbjct: 10  MAWF----GVL---SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWA 62

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
            K++ LTS +  D EG++ HPVNA+KL+KRLNT+W  LE+LVL+D + GFI+NL++QRQ+
Sbjct: 63  NKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQF 122

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FP DED++GAAKAL+RLQDTY LD  TIS+G LPG K+++ L+ +DCF +G+ AY E DY
Sbjct: 123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDY 182

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHT LWMEQ L+QLD GE +T  K  VLDYLSYAV+Q GDL +AL LT++LL LDP H+R
Sbjct: 183 YHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHER 242

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV---AVDYLPERQKYEMLCRGEG 297
           A GNL+YFE ++ +E++  K+ ++    +  TP+  G+    VDYLPER  YE LCRGEG
Sbjct: 243 AGGNLRYFEQLLEEERE--KTLTNQTEAELATPE--GIYERPVDYLPERDVYESLCRGEG 298

Query: 298 IKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAK 357
           +K+TPRRQK+LFCRYH GNR P+ ++AP K+EDEWD P I+R++D++SD EIE +K++AK
Sbjct: 299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

Query: 358 PRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQV 417
           P+L RAT+ +P TG L    YR+SKS+WL   ++PVV+R+N R+Q +TGL V TAE LQV
Sbjct: 359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQV 418

Query: 418 ANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477
           ANYGVGGQYEPHFDF+R DE D FK LGTGNR+AT+L YMSDV AGGATVFP++GA++WP
Sbjct: 419 ANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWP 478

Query: 478 KKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           KKGTAVFWYNL  SGEGDY TRHAACPVLVG KWVSNKW HERGQEF RPC  +E++
Sbjct: 479 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD 535


>gi|217272861 prolyl 4-hydroxylase, alpha II subunit isoform 2
           precursor [Homo sapiens]
          Length = 533

 Score =  681 bits (1757), Expect = 0.0
 Identities = 327/537 (60%), Positives = 415/537 (77%), Gaps = 16/537 (2%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           M W+    G+L   S     FFTSIG MTDLI+ EK+LV SLK+YI  EE KL +IK WA
Sbjct: 10  MAWF----GVL---SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWA 62

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
            K++ LTS +  D EG++ HPVNA+KL+KRLNT+W  LE+LVL+D + GFI+NL++QRQ+
Sbjct: 63  NKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQF 122

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FP DED++GAAKAL+RLQDTY LD  TIS+G LPG K+++ L+ +DCF +G+ AY E DY
Sbjct: 123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDY 182

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHT LWMEQ L+QLD GE +T  K  VLDYLSYAV+Q GDL +AL LT++LL LDP H+R
Sbjct: 183 YHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHER 242

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV---AVDYLPERQKYEMLCRGEG 297
           A GNL+YFE ++ +E++  K+ ++    +  TP  +G+    VDYLPER  YE LCRGEG
Sbjct: 243 AGGNLRYFEQLLEEERE--KTLTNQTEAELATP--EGIYERPVDYLPERDVYESLCRGEG 298

Query: 298 IKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAK 357
           +K+TPRRQK+LFCRYH GNR P+ ++AP K+EDEWD P I+R++D++SD EIE +K++AK
Sbjct: 299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

Query: 358 PRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQV 417
           P+L RAT+ +P TG L    YR+SKS+WL   ++PVV+R+N R+Q +TGL V TAE LQV
Sbjct: 359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQV 418

Query: 418 ANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477
           ANYGVGGQYEPHFDF+R+      K    GNR+AT+L YMSDV AGGATVFP++GA++WP
Sbjct: 419 ANYGVGGQYEPHFDFSRRPFDSGLKT--EGNRLATFLNYMSDVEAGGATVFPDLGAAIWP 476

Query: 478 KKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           KKGTAVFWYNL  SGEGDY TRHAACPVLVG KWVSNKW HERGQEF RPC  +E++
Sbjct: 477 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD 533


>gi|63252893 prolyl 4-hydroxylase, alpha II subunit isoform 2
           precursor [Homo sapiens]
          Length = 533

 Score =  681 bits (1757), Expect = 0.0
 Identities = 327/537 (60%), Positives = 415/537 (77%), Gaps = 16/537 (2%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           M W+    G+L   S     FFTSIG MTDLI+ EK+LV SLK+YI  EE KL +IK WA
Sbjct: 10  MAWF----GVL---SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWA 62

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
            K++ LTS +  D EG++ HPVNA+KL+KRLNT+W  LE+LVL+D + GFI+NL++QRQ+
Sbjct: 63  NKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQF 122

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FP DED++GAAKAL+RLQDTY LD  TIS+G LPG K+++ L+ +DCF +G+ AY E DY
Sbjct: 123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDY 182

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHT LWMEQ L+QLD GE +T  K  VLDYLSYAV+Q GDL +AL LT++LL LDP H+R
Sbjct: 183 YHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHER 242

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV---AVDYLPERQKYEMLCRGEG 297
           A GNL+YFE ++ +E++  K+ ++    +  TP  +G+    VDYLPER  YE LCRGEG
Sbjct: 243 AGGNLRYFEQLLEEERE--KTLTNQTEAELATP--EGIYERPVDYLPERDVYESLCRGEG 298

Query: 298 IKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAK 357
           +K+TPRRQK+LFCRYH GNR P+ ++AP K+EDEWD P I+R++D++SD EIE +K++AK
Sbjct: 299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

Query: 358 PRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQV 417
           P+L RAT+ +P TG L    YR+SKS+WL   ++PVV+R+N R+Q +TGL V TAE LQV
Sbjct: 359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQV 418

Query: 418 ANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477
           ANYGVGGQYEPHFDF+R+      K    GNR+AT+L YMSDV AGGATVFP++GA++WP
Sbjct: 419 ANYGVGGQYEPHFDFSRRPFDSGLKT--EGNRLATFLNYMSDVEAGGATVFPDLGAAIWP 476

Query: 478 KKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           KKGTAVFWYNL  SGEGDY TRHAACPVLVG KWVSNKW HERGQEF RPC  +E++
Sbjct: 477 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD 533


>gi|63252891 prolyl 4-hydroxylase, alpha II subunit isoform 2
           precursor [Homo sapiens]
          Length = 533

 Score =  681 bits (1757), Expect = 0.0
 Identities = 327/537 (60%), Positives = 415/537 (77%), Gaps = 16/537 (2%)

Query: 1   MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA 60
           M W+    G+L   S     FFTSIG MTDLI+ EK+LV SLK+YI  EE KL +IK WA
Sbjct: 10  MAWF----GVL---SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWA 62

Query: 61  EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY 120
            K++ LTS +  D EG++ HPVNA+KL+KRLNT+W  LE+LVL+D + GFI+NL++QRQ+
Sbjct: 63  NKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQF 122

Query: 121 FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY 180
           FP DED++GAAKAL+RLQDTY LD  TIS+G LPG K+++ L+ +DCF +G+ AY E DY
Sbjct: 123 FPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDY 182

Query: 181 YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR 240
           YHT LWMEQ L+QLD GE +T  K  VLDYLSYAV+Q GDL +AL LT++LL LDP H+R
Sbjct: 183 YHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHER 242

Query: 241 ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV---AVDYLPERQKYEMLCRGEG 297
           A GNL+YFE ++ +E++  K+ ++    +  TP  +G+    VDYLPER  YE LCRGEG
Sbjct: 243 AGGNLRYFEQLLEEERE--KTLTNQTEAELATP--EGIYERPVDYLPERDVYESLCRGEG 298

Query: 298 IKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAK 357
           +K+TPRRQK+LFCRYH GNR P+ ++AP K+EDEWD P I+R++D++SD EIE +K++AK
Sbjct: 299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAK 358

Query: 358 PRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQV 417
           P+L RAT+ +P TG L    YR+SKS+WL   ++PVV+R+N R+Q +TGL V TAE LQV
Sbjct: 359 PKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQV 418

Query: 418 ANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWP 477
           ANYGVGGQYEPHFDF+R+      K    GNR+AT+L YMSDV AGGATVFP++GA++WP
Sbjct: 419 ANYGVGGQYEPHFDFSRRPFDSGLKT--EGNRLATFLNYMSDVEAGGATVFPDLGAAIWP 476

Query: 478 KKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE 534
           KKGTAVFWYNL  SGEGDY TRHAACPVLVG KWVSNKW HERGQEF RPC  +E++
Sbjct: 477 KKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD 533


>gi|33589818 prolyl 4-hydroxylase, alpha III subunit precursor [Homo
           sapiens]
          Length = 544

 Score =  323 bits (827), Expect = 3e-88
 Identities = 201/552 (36%), Positives = 313/552 (56%), Gaps = 48/552 (8%)

Query: 5   ILIIGILLPQSLAHPG-FFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKL 63
           +L +G   P+  A  G  F+++  +   +  E+ L+  L+ Y++ EE +L  + ++ +K+
Sbjct: 13  VLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKV 72

Query: 64  DRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLV-----LKDMSDGFISNLTIQR 118
             L   +T      V +P+ AF L+KRL ++W  + + +     ++ + DG+        
Sbjct: 73  LSLHEDSTTP----VANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEK----VE 124

Query: 119 QYFPNDEDQVGAAKALLRLQDTYNLDTDTISKG-----------NLPGVKHKSFLTAEDC 167
           Q  P  ED  GAA+AL+RLQD Y L+   +++G           +L   K    LT +DC
Sbjct: 125 QDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDC 184

Query: 168 FELGKVAYTEADYYHTELWMEQALRQL--DEGEISTIDKVSV---LDYLSYAVYQQGDLD 222
           F++GKVAY   DYYH   W+E+A+       GE  T D+ S+   LD+L++A ++ G++ 
Sbjct: 185 FQVGKVAYDMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVS 244

Query: 223 KALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDY 282
            AL L+++ L   P+++R   N+  +E ++A+    N   ++    +   P        +
Sbjct: 245 CALSLSREFLLYSPDNKRMARNVLKYERLLAESP--NHVVAEAVIQRPNIP--------H 294

Query: 283 LPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHD 342
           L  R  YE LC+  G + T  +   L+C Y + N N   +L P ++E    +P I  +HD
Sbjct: 295 LQTRDTYEGLCQTLGSQPTLYQIPSLYCSY-ETNSNAYLLLQPIRKEVIHLEPYIALYHD 353

Query: 343 IISDAEIEIVKDLAKPRLRRATISNPITGDLET-VHYRISKSAWLSGYENPVVSRINMRI 401
            +SD+E + +++LA+P L+R+ +++   G+ +  V YRISKSAWL    +P +  +N RI
Sbjct: 354 FVSDSEAQKIRELAEPWLQRSVVAS---GEKQLQVEYRISKSAWLKDTVDPKLVTLNHRI 410

Query: 402 QDLTGLDVST--AEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSD 459
             LTGLDV    AE LQV NYG+GG YEPHFD A       ++ + +GNR+AT++ Y+S 
Sbjct: 411 AALTGLDVRPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYR-MKSGNRVATFMIYLSS 469

Query: 460 VSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHE 519
           V AGGAT F     SV   +  A+FW+NL  SGEGD  T HA CPVLVG+KWV+NKW+HE
Sbjct: 470 VEAGGATAFIYANLSVPVVRNAALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHE 529

Query: 520 RGQEFRRPCTLS 531
            GQEFRRPC+ S
Sbjct: 530 YGQEFRRPCSSS 541


>gi|29570771 hypoxia-inducible factor prolyl 4-hydroxylase isoform a
           [Homo sapiens]
          Length = 502

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 59/188 (31%), Positives = 75/188 (39%), Gaps = 49/188 (26%)

Query: 379 RISKSAWLSGYENP--VVSRINMRIQDLTGLD---VSTAEELQVANYGVGGQYEPHFDFA 433
           R S   WL   E    ++  I  R+  LT L    V  +E LQV  YG GG Y  H D  
Sbjct: 273 RNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSG 332

Query: 434 ----------RKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEV------------ 471
                      K   +      T  R  T LFY+++V+ GG TVFP              
Sbjct: 333 PVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQ 392

Query: 472 ---------------GASVWPKKGTAVFWYNLFASGEG------DYSTRHAACPVLVGNK 510
                             V P++GTAVFWYN    G+G      DYS  H  C V  G K
Sbjct: 393 DDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSL-HGGCLVTRGTK 451

Query: 511 WVSNKWLH 518
           W++N W++
Sbjct: 452 WIANNWIN 459


>gi|64085083 hypoxia-inducible factor prolyl 4-hydroxylase isoform c
           [Homo sapiens]
          Length = 563

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/100 (34%), Positives = 45/100 (45%), Gaps = 34/100 (34%)

Query: 452 TWLFYMSDVSAGGATVFPEV---------------------------GASVWPKKGTAVF 484
           T LFY+++V+ GG TVFP                                V P++GTAVF
Sbjct: 422 TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF 481

Query: 485 WYNLFASGEG------DYSTRHAACPVLVGNKWVSNKWLH 518
           WYN    G+G      DYS  H  C V  G KW++N W++
Sbjct: 482 WYNYLPDGQGWVGDVDDYSL-HGGCLVTRGTKWIANNWIN 520



 Score = 32.7 bits (73), Expect = 0.85
 Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 5/58 (8%)

Query: 379 RISKSAWLSGYENP--VVSRINMRIQDLTGLD---VSTAEELQVANYGVGGQYEPHFD 431
           R S   WL   E    ++  I  R+  LT L    V  +E LQV  YG GG Y  H D
Sbjct: 273 RNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVD 330


>gi|216548091 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 64/291 (21%), Positives = 124/291 (42%), Gaps = 33/291 (11%)

Query: 32  IHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRL 91
           I   +DL   +K+ ++ EE+   ++K   E+L +  +   K  E F     +  +L   L
Sbjct: 82  IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSL 141

Query: 92  NTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALL--RLQDTYNLDTDTIS 149
           N E     NL  K  S+  +  L ++ +   + ED++   +  L   L+   +L    +S
Sbjct: 142 NEE----RNLTKKISSE--LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195

Query: 150 KGNLPGVKHK--SFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTID---- 203
           +      K K    L  E   +L +      DY      +E+   ++++G  ST+     
Sbjct: 196 ERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKES 255

Query: 204 -KVSVLDYLSYAVYQQGDLDK----ALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDV 258
            +   LDYL     +  +  +          K+ +L+ E ++    +K+FE +  + K +
Sbjct: 256 RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKM 315

Query: 259 NKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLC-RGEGIKMTPRRQKKL 308
            KS ++D  D            +YL E+ K ++L  + E IK+  ++QK+L
Sbjct: 316 -KSKNNDLQD------------NYLSEQNKNKLLASQLEEIKLQIKKQKEL 353


>gi|216548085 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 38.5 bits (88), Expect = 0.016
 Identities = 64/291 (21%), Positives = 124/291 (42%), Gaps = 33/291 (11%)

Query: 32  IHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRL 91
           I   +DL   +K+ ++ EE+   ++K   E+L +  +   K  E F     +  +L   L
Sbjct: 82  IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSL 141

Query: 92  NTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALL--RLQDTYNLDTDTIS 149
           N E     NL  K  S+  +  L ++ +   + ED++   +  L   L+   +L    +S
Sbjct: 142 NEE----RNLTKKISSE--LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195

Query: 150 KGNLPGVKHK--SFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTID---- 203
           +      K K    L  E   +L +      DY      +E+   ++++G  ST+     
Sbjct: 196 ERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKES 255

Query: 204 -KVSVLDYLSYAVYQQGDLDK----ALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDV 258
            +   LDYL     +  +  +          K+ +L+ E ++    +K+FE +  + K +
Sbjct: 256 RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKM 315

Query: 259 NKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLC-RGEGIKMTPRRQKKL 308
            KS ++D  D            +YL E+ K ++L  + E IK+  ++QK+L
Sbjct: 316 -KSKNNDLQD------------NYLSEQNKNKLLASQLEEIKLQIKKQKEL 353


>gi|197313662 leprecan-like 1 isoform b [Homo sapiens]
          Length = 527

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 178 ADYYHTELWME-QALRQLDE--GEISTIDKVSVL--DYLSYAVYQQGDLDKALLLTKKLL 232
           AD+Y   L  + + +R+L    G +S I+    L  DYL +A Y+ G+  KAL   K  L
Sbjct: 93  ADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYL 152

Query: 233 ELDPEHQRANGNLKYFEYIM 252
              P+ +    N+ Y+E ++
Sbjct: 153 LCHPDDEDVLDNVDYYESLL 172


>gi|27764882 leprecan-like 1 isoform a [Homo sapiens]
          Length = 708

 Score = 33.9 bits (76), Expect = 0.38
 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 5/80 (6%)

Query: 178 ADYYHTELWME-QALRQLDE--GEISTIDKVSVL--DYLSYAVYQQGDLDKALLLTKKLL 232
           AD+Y   L  + + +R+L    G +S I+    L  DYL +A Y+ G+  KAL   K  L
Sbjct: 274 ADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYL 333

Query: 233 ELDPEHQRANGNLKYFEYIM 252
              P+ +    N+ Y+E ++
Sbjct: 334 LCHPDDEDVLDNVDYYESLL 353


>gi|64276486 serologically defined colon cancer antigen 10 [Homo
           sapiens]
          Length = 472

 Score = 33.5 bits (75), Expect = 0.50
 Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 4/82 (4%)

Query: 229 KKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSA--SDDQSDQKTTPKKKGVAVDYLPER 286
           KK +    E ++    LK  E + AK+K V  +A  ++ +S+++  P    VA +Y  E+
Sbjct: 307 KKSVSRSEELRKEARQLKR-ELLAAKQKKVENAAKQAEKRSEEEEAPPDGAVA-EYRREK 364

Query: 287 QKYEMLCRGEGIKMTPRRQKKL 308
           QKYE L + +  K T R  + L
Sbjct: 365 QKYEALRKQQSKKGTSREDQTL 386


>gi|4826870 nucleobindin 2 [Homo sapiens]
          Length = 420

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 57/249 (22%), Positives = 100/249 (40%), Gaps = 61/249 (24%)

Query: 33  HTEKDLVTSL-KDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRL 91
           H  ++ + +L ++  K EE K E++KK  E   ++    +KD                +L
Sbjct: 186 HERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKD----------------QL 229

Query: 92  NTEWSELENLVLKDM------------SDGFIS--------NLTIQRQYFPNDE--DQVG 129
              W E + L   D             SDGF+            +++ Y P +E  D V 
Sbjct: 230 KEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVE 289

Query: 130 AAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQ 189
             +  LR+++    + DT +K  L  V  + FL A +     K  + E D + T      
Sbjct: 290 MEEERLRMREHVMNEVDT-NKDRL--VTLEEFLKATE-----KKEFLEPDSWET------ 335

Query: 190 ALRQLDEGEISTIDKVSVLDYLSYAVYQQGDL-DKALLLTKKLLELDPEHQRANG-NLKY 247
               LD+ +  T +++   +Y +    Q+ +L  KA  L K+  EL  +H +     L+Y
Sbjct: 336 ----LDQQQFFTEEELK--EYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEY 389

Query: 248 FEYIMAKEK 256
            + I   E+
Sbjct: 390 HQVIQQMEQ 398


>gi|238859557 regulatory factor X1 [Homo sapiens]
          Length = 979

 Score = 32.0 bits (71), Expect = 1.5
 Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 35  EKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTE 94
           E  +V  L+   K    +   +++WA  LD + S   K  +G  G P    K  K    +
Sbjct: 797 EDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFP----KAAKLFLLK 852

Query: 95  WSELENLVLKDMS 107
           WS   ++V++D++
Sbjct: 853 WSFYSSMVIRDLT 865


>gi|10337581 type I hair keratin 3B [Homo sapiens]
          Length = 404

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 22/70 (31%), Positives = 40/70 (57%), Gaps = 6/70 (8%)

Query: 178 ADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKAL-LLTKKLLELDP 236
           AD + T+   EQ+LRQL E +I+++ +  +LD L+     + DL+  +  L ++LL L  
Sbjct: 138 ADDFRTKYQTEQSLRQLVESDINSLRR--ILDELTLC---RSDLEAQMESLKEELLSLKQ 192

Query: 237 EHQRANGNLK 246
            H++    L+
Sbjct: 193 NHEQEVNTLR 202


>gi|186928835 leprecan 1 isoform 1 [Homo sapiens]
          Length = 736

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 23/107 (21%), Positives = 40/107 (37%), Gaps = 15/107 (14%)

Query: 204 KVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIM-AKEKDVNKSA 262
           K S  +YL  A ++   L+KA+         +PEH     NL Y++ +   KE D     
Sbjct: 142 KRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMQQNLDYYQTMSGVKEADFKDLE 201

Query: 263 S--------------DDQSDQKTTPKKKGVAVDYLPERQKYEMLCRG 295
           +               ++  Q+  P  +    +Y    ++   LC G
Sbjct: 202 TQPHMQEFRLGVRLYSEEQPQEAVPHLEAALQEYFVAYEECRALCEG 248


>gi|226371643 leprecan 1 isoform 2 [Homo sapiens]
          Length = 697

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 23/107 (21%), Positives = 40/107 (37%), Gaps = 15/107 (14%)

Query: 204 KVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIM-AKEKDVNKSA 262
           K S  +YL  A ++   L+KA+         +PEH     NL Y++ +   KE D     
Sbjct: 142 KRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMQQNLDYYQTMSGVKEADFKDLE 201

Query: 263 S--------------DDQSDQKTTPKKKGVAVDYLPERQKYEMLCRG 295
           +               ++  Q+  P  +    +Y    ++   LC G
Sbjct: 202 TQPHMQEFRLGVRLYSEEQPQEAVPHLEAALQEYFVAYEECRALCEG 248


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 30.8 bits (68), Expect = 3.2
 Identities = 45/197 (22%), Positives = 79/197 (40%), Gaps = 25/197 (12%)

Query: 169 ELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYA-----VYQQG---- 219
           EL +    E D +  E+ + Q   Q    EIS   +  + DY         + QQG    
Sbjct: 220 ELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGV 279

Query: 220 ---DLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKK 276
              DL K   + K +  L  E   +    K  E +  K KD+NK  S  ++D+    +++
Sbjct: 280 IETDLSKIYEMQKTIQVLQIEKVEST---KKMEQLEDKIKDINKKLSSAENDRDILRREQ 336

Query: 277 GVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPR 336
                     +K +++   E +K+   + +    +  D     + ILA +   +E     
Sbjct: 337 EQL-----NVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEE----- 386

Query: 337 IIRFHDIISDAEIEIVK 353
           + R    +SDAE EI++
Sbjct: 387 VFRLQQALSDAENEIMR 403


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 17   AHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEK-------LDRLTST 69
            A+ G  +    MTD+ H  +DL   LKD I     KL +++K  E+       L ++  T
Sbjct: 2419 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2478

Query: 70   ATK 72
            ATK
Sbjct: 2479 ATK 2481


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 17   AHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEK-------LDRLTST 69
            A+ G  +    MTD+ H  +DL   LKD I     KL +++K  E+       L ++  T
Sbjct: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2489

Query: 70   ATK 72
            ATK
Sbjct: 2490 ATK 2492


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 17   AHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEK-------LDRLTST 69
            A+ G  +    MTD+ H  +DL   LKD I     KL +++K  E+       L ++  T
Sbjct: 2568 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2627

Query: 70   ATK 72
            ATK
Sbjct: 2628 ATK 2630


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 17   AHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEK-------LDRLTST 69
            A+ G  +    MTD+ H  +DL   LKD I     KL +++K  E+       L ++  T
Sbjct: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2449

Query: 70   ATK 72
            ATK
Sbjct: 2450 ATK 2452


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 17   AHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEK-------LDRLTST 69
            A+ G  +    MTD+ H  +DL   LKD I     KL +++K  E+       L ++  T
Sbjct: 2064 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2123

Query: 70   ATK 72
            ATK
Sbjct: 2124 ATK 2126


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 30.4 bits (67), Expect = 4.2
 Identities = 26/108 (24%), Positives = 45/108 (41%), Gaps = 14/108 (12%)

Query: 32   IHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRL 91
            +  EK     LKD +K EE++L+  K++ EK  +L S   +   G   H  N  KL  ++
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243

Query: 92   NT----------EWSELENLV--LKDMSDGFISNLTIQRQYFPNDEDQ 127
                        EW   +  V  L+  +D     + +      N++D+
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291


>gi|5453629 dynactin 2 [Homo sapiens]
          Length = 406

 Score = 29.6 bits (65), Expect = 7.2
 Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 10/88 (11%)

Query: 218 QGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKG 277
           Q + D      ++L     EH   N N  Y ++   K+K V     D  SD+    K+ G
Sbjct: 30  QAEFDAFAQELEELTSTSVEHIIVNPNAAYDKF---KDKRVGTKGLDF-SDRIGKTKRTG 85

Query: 278 VAVDYLPERQKYEMLCRGEGIKMTPRRQ 305
                  E  +YEML  G G+K TP+++
Sbjct: 86  Y------ESGEYEMLGEGLGVKETPQQK 107


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,711,385
Number of Sequences: 37866
Number of extensions: 932177
Number of successful extensions: 2546
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 2475
Number of HSP's gapped (non-prelim): 78
length of query: 534
length of database: 18,247,518
effective HSP length: 107
effective length of query: 427
effective length of database: 14,195,856
effective search space: 6061630512
effective search space used: 6061630512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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