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Search of human proteins with 63003905
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo
sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens] 719 0.0
gi|167466276 protein phosphatase 1K (PP2C domain containing) [Ho... 130 2e-30
gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens] 126 3e-29
gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens] 126 3e-29
gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens] 126 3e-29
gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens] 126 3e-29
gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens] 124 1e-28
gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens] 124 1e-28
gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens] 124 1e-28
gi|30089948 protein phosphatase 1E [Homo sapiens] 115 5e-26
gi|13540531 integrin-linked kinase-associated protein phosphatas... 115 5e-26
gi|7661862 protein phosphatase 1F [Homo sapiens] 112 7e-25
gi|122937199 protein phosphatase 1B-like [Homo sapiens] 108 7e-24
gi|4505999 protein phosphatase 1G [Homo sapiens] 100 2e-21
gi|29826282 protein phosphatase 1G [Homo sapiens] 100 2e-21
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 76 5e-14
gi|4505997 protein phosphatase 1D [Homo sapiens] 74 2e-13
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 71 1e-12
gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo... 64 2e-10
gi|171460932 protein phosphatase 1M isoform a [Homo sapiens] 58 2e-08
gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit ... 56 6e-08
gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit... 56 6e-08
gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit... 56 6e-08
gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit... 56 6e-08
gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit... 56 6e-08
gi|171460934 protein phosphatase 1M isoform b [Homo sapiens] 54 2e-07
gi|149944715 protein phosphatase 1H (PP2C domain containing) [Ho... 54 2e-07
gi|5174703 mitogen-activated protein kinase kinase kinase 7 inte... 46 5e-05
gi|41281798 mitogen-activated protein kinase kinase kinase 7 int... 46 5e-05
gi|65506328 protein phosphatase 1J (PP2C domain containing) [Hom... 38 0.012
>gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]
Length = 360
Score = 719 bits (1857), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK 60
MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK
Sbjct: 1 MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK 60
Query: 61 GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH 120
GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH
Sbjct: 61 GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH 120
Query: 121 PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM 180
PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM
Sbjct: 121 PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM 180
Query: 181 LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK 240
LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK
Sbjct: 181 LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK 240
Query: 241 RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA 300
RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA
Sbjct: 241 RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA 300
Query: 301 SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ
Sbjct: 301 SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
>gi|167466276 protein phosphatase 1K (PP2C domain containing) [Homo
sapiens]
Length = 372
Score = 130 bits (327), Expect = 2e-30
Identities = 93/268 (34%), Positives = 143/268 (53%), Gaps = 23/268 (8%)
Query: 92 NVAVYSIQGRRDHMEDRFEVLTDLANKTHPSI-FGIFDGHGGETAAEYVKSRLPEALKQH 150
NV S G+R EDRF D A T + F ++DGHGG AA++ + + + +
Sbjct: 94 NVGCASQIGKRKENEDRF----DFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDL 149
Query: 151 LQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDE----AGTTCLIALLSDK-DL 205
L KE ++ +T+L L ID+ +S D +GTT +ALL D +L
Sbjct: 150 LP-----KEKNL---ETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRDGIEL 201
Query: 206 TVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN--GSWRVQGILAM 263
VA+VGDSR +LC K G + L+ DH P + E++RIK+ GGF+++N G V G LAM
Sbjct: 202 VVASVGDSRAILCRK-GKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAM 260
Query: 264 SRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDE 323
+RS+GD LK + VI +P+ L F++L +DG+ +++E F+ + +
Sbjct: 261 TRSIGDLDLKT-SGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQ-CHD 318
Query: 324 PHFGAKSIVLQSFYRGCPDNITVMVVKF 351
P+ A ++ Q+ G DN T +VV F
Sbjct: 319 PNEAAHAVTEQAIQYGTEDNSTAVVVPF 346
>gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]
Length = 380
Score = 126 bits (316), Expect = 3e-29
Identities = 89/282 (31%), Positives = 140/282 (49%), Gaps = 23/282 (8%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + + + S F ++DGH G A Y + L E + +
Sbjct: 28 SMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA 87
Query: 156 KDKENSVL-----SYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVA 208
K S L + + + L ID M L D +G+T + ++S K +
Sbjct: 88 AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFI 147
Query: 209 NVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLG 268
N GDSR VL ++G + DHKP +E++RI+ AGG + RV G LA+SR+LG
Sbjct: 148 NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRALG 203
Query: 269 DYPLKNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL 321
DY K ++ +V P+P++ L + EF+ILA DG+WD SNEE ++K RL
Sbjct: 204 DYDYKCVDGKGPTEQLVSPEPEVYEI-LRAEEDEFIILACDGIWDVMSNEELCEYVKSRL 262
Query: 322 ---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
D+ +V ++G DN+++++V F N+ K ++
Sbjct: 263 EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDE 304
>gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]
Length = 327
Score = 126 bits (316), Expect = 3e-29
Identities = 89/282 (31%), Positives = 140/282 (49%), Gaps = 23/282 (8%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + + + S F ++DGH G A Y + L E + +
Sbjct: 28 SMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA 87
Query: 156 KDKENSVL-----SYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVA 208
K S L + + + L ID M L D +G+T + ++S K +
Sbjct: 88 AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFI 147
Query: 209 NVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLG 268
N GDSR VL ++G + DHKP +E++RI+ AGG + RV G LA+SR+LG
Sbjct: 148 NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRALG 203
Query: 269 DYPLKNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL 321
DY K ++ +V P+P++ L + EF+ILA DG+WD SNEE ++K RL
Sbjct: 204 DYDYKCVDGKGPTEQLVSPEPEVYEI-LRAEEDEFIILACDGIWDVMSNEELCEYVKSRL 262
Query: 322 ---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
D+ +V ++G DN+++++V F N+ K ++
Sbjct: 263 EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDE 304
>gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]
Length = 387
Score = 126 bits (316), Expect = 3e-29
Identities = 89/282 (31%), Positives = 140/282 (49%), Gaps = 23/282 (8%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + + + S F ++DGH G A Y + L E + +
Sbjct: 28 SMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA 87
Query: 156 KDKENSVL-----SYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVA 208
K S L + + + L ID M L D +G+T + ++S K +
Sbjct: 88 AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFI 147
Query: 209 NVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLG 268
N GDSR VL ++G + DHKP +E++RI+ AGG + RV G LA+SR+LG
Sbjct: 148 NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRALG 203
Query: 269 DYPLKNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL 321
DY K ++ +V P+P++ L + EF+ILA DG+WD SNEE ++K RL
Sbjct: 204 DYDYKCVDGKGPTEQLVSPEPEVYEI-LRAEEDEFIILACDGIWDVMSNEELCEYVKSRL 262
Query: 322 ---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
D+ +V ++G DN+++++V F N+ K ++
Sbjct: 263 EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDE 304
>gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]
Length = 479
Score = 126 bits (316), Expect = 3e-29
Identities = 89/282 (31%), Positives = 140/282 (49%), Gaps = 23/282 (8%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + + + S F ++DGH G A Y + L E + +
Sbjct: 28 SMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRA 87
Query: 156 KDKENSVL-----SYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVA 208
K S L + + + L ID M L D +G+T + ++S K +
Sbjct: 88 AGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFI 147
Query: 209 NVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLG 268
N GDSR VL ++G + DHKP +E++RI+ AGG + RV G LA+SR+LG
Sbjct: 148 NCGDSRAVLY-RNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRALG 203
Query: 269 DYPLKNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL 321
DY K ++ +V P+P++ L + EF+ILA DG+WD SNEE ++K RL
Sbjct: 204 DYDYKCVDGKGPTEQLVSPEPEVYEI-LRAEEDEFIILACDGIWDVMSNEELCEYVKSRL 262
Query: 322 ---DEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
D+ +V ++G DN+++++V F N+ K ++
Sbjct: 263 EVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDE 304
>gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]
Length = 382
Score = 124 bits (311), Expect = 1e-28
Identities = 86/278 (30%), Positives = 141/278 (50%), Gaps = 19/278 (6%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + L + S F ++DGH G A+Y L + + + QD++
Sbjct: 28 SMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFK 86
Query: 156 KDK-ENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVANVGD 212
SV + + + L ID M + + D +G+T + L+S + N GD
Sbjct: 87 GSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD 146
Query: 213 SRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPL 272
SRG+LC ++ + DHKP E++RI+ AGG + RV G LA+SR+LGD+
Sbjct: 147 SRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRALGDFDY 202
Query: 273 KNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL---D 322
K ++ +V P+P++ + + +F+ILA DG+WD NEE F++ RL D
Sbjct: 203 KCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD 262
Query: 323 EPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
+ +V Y+G DN++V+++ F N+ K +
Sbjct: 263 DLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 300
>gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]
Length = 324
Score = 124 bits (311), Expect = 1e-28
Identities = 86/278 (30%), Positives = 141/278 (50%), Gaps = 19/278 (6%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + L + S F ++DGH G A+Y L + + + QD++
Sbjct: 28 SMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFK 86
Query: 156 KDK-ENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVANVGD 212
SV + + + L ID M + + D +G+T + L+S + N GD
Sbjct: 87 GSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD 146
Query: 213 SRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPL 272
SRG+LC ++ + DHKP E++RI+ AGG + RV G LA+SR+LGD+
Sbjct: 147 SRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRALGDFDY 202
Query: 273 KNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL---D 322
K ++ +V P+P++ + + +F+ILA DG+WD NEE F++ RL D
Sbjct: 203 KCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD 262
Query: 323 EPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
+ +V Y+G DN++V+++ F N+ K +
Sbjct: 263 DLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 300
>gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
Length = 455
Score = 124 bits (311), Expect = 1e-28
Identities = 86/278 (30%), Positives = 141/278 (50%), Gaps = 19/278 (6%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
S+QG R MED + L + S F ++DGH G A+Y L + + + QD++
Sbjct: 101 SMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFK 159
Query: 156 KDK-ENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVANVGD 212
SV + + + L ID M + + D +G+T + L+S + N GD
Sbjct: 160 GSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD 219
Query: 213 SRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPL 272
SRG+LC ++ + DHKP E++RI+ AGG + RV G LA+SR+LGD+
Sbjct: 220 SRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRALGDFDY 275
Query: 273 KNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL---D 322
K ++ +V P+P++ + + +F+ILA DG+WD NEE F++ RL D
Sbjct: 276 KCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD 335
Query: 323 EPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
+ +V Y+G DN++V+++ F N+ K +
Sbjct: 336 DLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 373
>gi|30089948 protein phosphatase 1E [Homo sapiens]
Length = 755
Score = 115 bits (289), Expect = 5e-26
Identities = 85/276 (30%), Positives = 141/276 (51%), Gaps = 22/276 (7%)
Query: 91 HNVAVYSIQGRRDHMEDR------FEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLP 144
+ ++++I+ R MED+ F +L +L ++ + F +FDGHGG AA Y L
Sbjct: 230 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 289
Query: 145 EALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKD 204
L + E +++ E+ + RE L GTT ++ +
Sbjct: 290 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLR--------CGTTGVVTFIRGNM 341
Query: 205 LTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMS 264
L VA VGDS+ +L K G A+ L HKP + E++RI+ GG + + G+WRV G L++S
Sbjct: 342 LHVAWVGDSQVMLVRK-GQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVS 400
Query: 265 RSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEP 324
R++GD ++ + D D + LD + +++ILA DG +D + +EAV+ + + L E
Sbjct: 401 RAIGD--AEHKPYICGDADSASTVLDGTE-DYLILACDGFYDTVNPDEAVKVVSDHLKEN 457
Query: 325 H----FGAKSIVLQSFYRGCPDNITVMVVKFRNSSK 356
+ A +V + G DNITV+VV R+ +K
Sbjct: 458 NGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNK 493
>gi|13540531 integrin-linked kinase-associated protein phosphatase
2C [Homo sapiens]
Length = 392
Score = 115 bits (289), Expect = 5e-26
Identities = 90/288 (31%), Positives = 140/288 (48%), Gaps = 49/288 (17%)
Query: 99 QGRRDHMEDRFEVLTDLANKTHP--------SIFGIFDGHGGETAAEYVKSRLPEALKQH 150
+G R+ M+D +L D+ + P S F +FDGHGG A+++ L + L
Sbjct: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNL--- 171
Query: 151 LQDYEKDKENSVLSYQTILEQQILSI----DREMLEKLTVSY----DEAGTTCLIALLSD 202
K + V+S + +++ +L D E L++ + D + TC++A+ D
Sbjct: 172 ---IRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAV--D 226
Query: 203 KDLTVANVGDSRGVLC-----DKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRV 257
L +AN+GDSR +LC + A+ LS +H P Q +ER RI++AGG + RV
Sbjct: 227 NILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVR---DGRV 283
Query: 258 QGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFI 317
G+L +SRS+GD K V PDI L F++LA DGL+ F+ EEAV FI
Sbjct: 284 LGVLEVSRSIGDGQYKRCGVT-SVPDIRRCQLTP-NDRFILLACDGLFKVFTPEEAVNFI 341
Query: 318 KERLDEPHFGAKS---------------IVLQSFYRGCPDNITVMVVK 350
L++ + + ++ RG DN+TVMVV+
Sbjct: 342 LSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVR 389
>gi|7661862 protein phosphatase 1F [Homo sapiens]
Length = 454
Score = 112 bits (279), Expect = 7e-25
Identities = 87/278 (31%), Positives = 138/278 (49%), Gaps = 24/278 (8%)
Query: 93 VAVYSIQGRRDHMEDR------FEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRL-PE 145
V++++I+ R MEDR F L L++ + + F +FDGHGG AA Y +
Sbjct: 157 VSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTN 216
Query: 146 ALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDL 205
A +Q + D E + L + D+ L K ++GTT + AL++ L
Sbjct: 217 AARQ--PELPTDPEGA-------LREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATL 267
Query: 206 TVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSR 265
VA +GDS+ +L + G + L H+P + E+ RI+ GGF+S WRV G LA+SR
Sbjct: 268 HVAWLGDSQVILVQQ-GQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSR 326
Query: 266 SLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
++GD K V + D + L + ++++LA DG +D ++E V ++ L
Sbjct: 327 AIGDVFQK--PYVSGEADAASRALTGSE-DYLLLACDGFFDVVPHQEVVGLVQSHLTRQQ 383
Query: 326 FG----AKSIVLQSFYRGCPDNITVMVVKFRNSSKTEE 359
A+ +V + RG DNITVMVV R+ + E
Sbjct: 384 GSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELLE 421
>gi|122937199 protein phosphatase 1B-like [Homo sapiens]
Length = 430
Score = 108 bits (270), Expect = 7e-24
Identities = 86/273 (31%), Positives = 129/273 (47%), Gaps = 21/273 (7%)
Query: 99 QGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKD 157
QG R MED L ++F + DGHGG AA + LP + Q L +
Sbjct: 73 QGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQELGPEPSE 132
Query: 158 KENSVLSYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVL 217
E + L + LS D E L L + G T ++ L+S + L +A+ GDSR VL
Sbjct: 133 PEG----VREALRRAFLSAD-ERLRSLWPRVETGGCTAVVLLVSPRFLYLAHCGDSRAVL 187
Query: 218 CDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKN--- 274
+ G + DH+P + +ER+RI AGG I RV+G LA+SR+LGD+ K
Sbjct: 188 -SRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRR---RVEGSLAVSRALGDFTYKEAPG 243
Query: 275 ----LNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLD---EPHFG 327
L +V +P++ + + EFM+LASDG+WD S + RL P
Sbjct: 244 RPPELQLVSAEPEVAAL-ARQAEDEFMLLASDGVWDTVSGAALAGLVASRLRLGLAPELL 302
Query: 328 AKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
++ +G DN+T ++V F + + E+
Sbjct: 303 CAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEE 335
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 100 bits (249), Expect = 2e-21
Identities = 66/196 (33%), Positives = 105/196 (53%), Gaps = 32/196 (16%)
Query: 190 EAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFI 249
++GTT ++AL+ K L VAN GDSR V+ + G A+ +S+DHKP E RIK AGG +
Sbjct: 326 DSGTTAVVALIRGKQLIVANAGDSRCVVSEA-GKALDMSYDHKPEDEVELARIKNAGGKV 384
Query: 250 SFNGSWRVQGILAMSRSLGDY---------PLKNLNVVIPDPDILTFDLDKLQPEFMILA 300
+ +G RV G L +SR++GD+ P + + +PD +LT D EFM++A
Sbjct: 385 TMDG--RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDH---EFMVIA 439
Query: 301 SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYR----------------GCPDNI 344
DG+W+ S++E V FI+ ++ + + +L S GC DN+
Sbjct: 440 CDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGC-DNM 498
Query: 345 TVMVVKFRNSSKTEEQ 360
T +++ F+ + E Q
Sbjct: 499 TCIIICFKPRNTAELQ 514
Score = 46.2 bits (108), Expect = 5e-05
Identities = 29/84 (34%), Positives = 46/84 (54%), Gaps = 9/84 (10%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK 156
++QG R MED + +L ++T ++F ++DGHGGE A Y LP+ +K D +
Sbjct: 31 AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPDIIK----DQKA 84
Query: 157 DKENSVLSYQTILEQQILSIDREM 180
KE + Q LE L+ID ++
Sbjct: 85 YKEGKL---QKALEDAFLAIDAKL 105
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 100 bits (249), Expect = 2e-21
Identities = 66/196 (33%), Positives = 105/196 (53%), Gaps = 32/196 (16%)
Query: 190 EAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFI 249
++GTT ++AL+ K L VAN GDSR V+ + G A+ +S+DHKP E RIK AGG +
Sbjct: 326 DSGTTAVVALIRGKQLIVANAGDSRCVVSEA-GKALDMSYDHKPEDEVELARIKNAGGKV 384
Query: 250 SFNGSWRVQGILAMSRSLGDY---------PLKNLNVVIPDPDILTFDLDKLQPEFMILA 300
+ +G RV G L +SR++GD+ P + + +PD +LT D EFM++A
Sbjct: 385 TMDG--RVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDH---EFMVIA 439
Query: 301 SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYR----------------GCPDNI 344
DG+W+ S++E V FI+ ++ + + +L S GC DN+
Sbjct: 440 CDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGC-DNM 498
Query: 345 TVMVVKFRNSSKTEEQ 360
T +++ F+ + E Q
Sbjct: 499 TCIIICFKPRNTAELQ 514
Score = 46.2 bits (108), Expect = 5e-05
Identities = 29/84 (34%), Positives = 46/84 (54%), Gaps = 9/84 (10%)
Query: 97 SIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK 156
++QG R MED + +L ++T ++F ++DGHGGE A Y LP+ +K D +
Sbjct: 31 AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPDIIK----DQKA 84
Query: 157 DKENSVLSYQTILEQQILSIDREM 180
KE + Q LE L+ID ++
Sbjct: 85 YKEGKL---QKALEDAFLAIDAKL 105
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 75.9 bits (185), Expect = 5e-14
Identities = 72/236 (30%), Positives = 113/236 (47%), Gaps = 25/236 (10%)
Query: 122 SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREML 181
+++G+FDG ++ + + L + LQ + ++E V ++ I+ Q+ L + L
Sbjct: 692 ALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTF--IVMQRKLGTAGQKL 749
Query: 182 EKLTVSYDEAGTTCLIALLSDK-------DLTVANVGDSRGVLCDKDGNAIPLSHDHKPY 234
G L + D LT ANVG + VLC ++G +PLS +
Sbjct: 750 ---------GGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLC-RNGKPLPLSRSYIMS 799
Query: 235 QLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQP 294
+E KRIK+ I+ +G +V G+ +R LG Y + +VV P P + + L Q
Sbjct: 800 CEEELKRIKQHKAIITEDG--KVNGVTESTRILG-YTFLHPSVV-PRPHVQSVLLTP-QD 854
Query: 295 EFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVK 350
EF IL S GLWD+ S EEAV ++ D K L Y GC D+I+ +VV+
Sbjct: 855 EFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSY-GCHDSISAVVVQ 909
>gi|4505997 protein phosphatase 1D [Homo sapiens]
Length = 605
Score = 73.9 bits (180), Expect = 2e-13
Identities = 64/243 (26%), Positives = 113/243 (46%), Gaps = 43/243 (17%)
Query: 122 SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREML 181
+ F + DGHGG AA++ + L +K+ + + + V + + + L+ M
Sbjct: 99 AFFAVCDGHGGREAAQFAREHLWGFIKKQ-KGFTSSEPAKVCA---AIRKGFLACHLAMW 154
Query: 182 EKL-------TVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDG------NAIPLS 228
+KL T +GTT + ++ + VA+VGDS VL +D A+ ++
Sbjct: 155 KKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVT 214
Query: 229 HDHKPYQLKERKRIKRAGGFI----------------SFNGSWRVQGI------LAMSRS 266
DHKP KER+RI+ GG + + NG R + LA++R+
Sbjct: 215 QDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARA 274
Query: 267 LGDYPLKNLN----VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLD 322
LGD + VV P+PD LD + +++IL SDGLW+ ++A+ +++ +
Sbjct: 275 LGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEE 334
Query: 323 EPH 325
+ +
Sbjct: 335 KKY 337
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 71.2 bits (173), Expect = 1e-12
Identities = 66/243 (27%), Positives = 113/243 (46%), Gaps = 40/243 (16%)
Query: 122 SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREML 181
+++G+FDG E ++ + + L L++ ++ ++V T L
Sbjct: 814 AVYGMFDGDRNEELPRLLQCTMADVL---LEEVQQSTNDTVFMANTFLVSH--------- 861
Query: 182 EKLTVSYDEAGTTCLIALL--------SDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKP 233
KL ++ + G++ L+ + S LTVANVG + VLC + G +PLS K
Sbjct: 862 RKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLC-RGGKPVPLS---KV 917
Query: 234 YQLK----ERKRIKRAGGFISFNGSWRVQGILAMSRSLGD---YPLKNLNVVIPDPDILT 286
+ L+ E +R+K I+ + +V G+ +R LG YP ++P P I +
Sbjct: 918 FSLEQDPEEAQRVKDQKAIITEDN--KVNGVTCCTRMLGCTYLYPW-----ILPKPHISS 970
Query: 287 FDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITV 346
L +Q E +IL + LW+ S EAV ++ + +P AK + + GC DN+
Sbjct: 971 TPLT-IQDELLILGNKALWEHLSYTEAVNAVR-HVQDPLAAAKKLCTLAQSYGCQDNVGA 1028
Query: 347 MVV 349
MVV
Sbjct: 1029 MVV 1031
>gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo
sapiens]
Length = 529
Score = 64.3 bits (155), Expect = 2e-10
Identities = 80/317 (25%), Positives = 120/317 (37%), Gaps = 101/317 (31%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGG----------------------------ETAA 136
+EDR V + L +T+ +FGIFDGHGG E A
Sbjct: 120 VEDRRGVASCL--QTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAM 177
Query: 137 EYVKSRLP--EALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM-------------- 180
E +K LP LK KD + L + + Q++L + EM
Sbjct: 178 ESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQR 237
Query: 181 -----------------LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGN 223
L++ +G T +A + L VAN GD R +L ++ N
Sbjct: 238 LDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDN 297
Query: 224 ----AIPLSHDHKPYQLKERKRIKR---AGGFISFNGSWRVQGILAMSRSLGDYPLK--- 273
+PL+ DH + E R+KR + R+ G+L R+ GD LK
Sbjct: 298 GMWSCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSK 357
Query: 274 --------------NLNV-------------VIPDPDILTFDLDKLQPEFMILASDGLWD 306
LN+ + +P++ T+ + Q +F++LASDGLWD
Sbjct: 358 ELQRSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEV-TYHRLRPQDKFLVLASDGLWD 416
Query: 307 AFSNEEAVRFIKERLDE 323
SNE+ VR + L E
Sbjct: 417 MLSNEDVVRLVVGHLAE 433
>gi|171460932 protein phosphatase 1M isoform a [Homo sapiens]
Length = 298
Score = 57.8 bits (138), Expect = 2e-08
Identities = 62/244 (25%), Positives = 99/244 (40%), Gaps = 70/244 (28%)
Query: 169 LEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLS 228
LE D + +L S G T L+A+ L +AN GDSR +L +D PLS
Sbjct: 31 LESAFQECDEVIGRELEASGQMGGCTALVAVSLQGKLYMANAGDSRAILVRRD-EIRPLS 89
Query: 229 HDHKPYQLKERKRIKR---------AGGFISFN---------------------GSW--- 255
+ P ER+RI++ AG F W
Sbjct: 90 FEFTPET--ERQRIQQLAFVYPELLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYK 147
Query: 256 -------------------RVQGILAMSRSLGDYPLKNLNV-------VIPDPDILTFDL 289
R+ G LA+SR LGD+ L+ L+ ++ P + D+
Sbjct: 148 RVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDV 207
Query: 290 DKLQ---PEFMILASDGLWDAFSNEEAVRFIKERL----DEPH-FGAKSIVLQSFYRGCP 341
D+L+ + +++A+DGLWD SNE+ ++ L ++PH F + +L +G
Sbjct: 208 DQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFLPGNQEDPHRFSKLAQMLIHSTQGKE 267
Query: 342 DNIT 345
D++T
Sbjct: 268 DSLT 271
>gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 55.8 bits (133), Expect = 6e-08
Identities = 63/240 (26%), Positives = 97/240 (40%), Gaps = 57/240 (23%)
Query: 126 IFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLT 185
+ D + GE+ VK L A K+ L LE Q+ L L
Sbjct: 219 LIDLNTGESTDIDVKEALINAFKR-------------LDNDISLEAQV-GDPNSFLNYLV 264
Query: 186 VSYDEAGTTCLIALLSDKDLTVANVGDSRGVL--CDKDG--NAIPLSHDHKPYQLKERKR 241
+ +G T +A + DL VAN GDSR +L ++DG +A+ LS+DH +E +R
Sbjct: 265 LRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELER 324
Query: 242 IK------RAGGFISFNGSWRVQGILAMSRSLGDYPLK-----NLNVVIPDPDIL----- 285
+K A + + R+ G+L R+ GD K V+ PD L
Sbjct: 325 LKLEHPKSEAKSVVKQD---RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEY 381
Query: 286 --------------------TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
T+ + Q +F++LA+DGLW+ ++ VR + E L H
Sbjct: 382 TKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH 441
Score = 30.0 bits (66), Expect = 3.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSV 162
+EDR T L +T + G+FDGH G ++ V RL + L +E + EN+V
Sbjct: 123 IEDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV 180
Query: 163 LSYQTIL 169
S + +L
Sbjct: 181 ESGRALL 187
>gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 55.8 bits (133), Expect = 6e-08
Identities = 63/240 (26%), Positives = 97/240 (40%), Gaps = 57/240 (23%)
Query: 126 IFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLT 185
+ D + GE+ VK L A K+ L LE Q+ L L
Sbjct: 219 LIDLNTGESTDIDVKEALINAFKR-------------LDNDISLEAQV-GDPNSFLNYLV 264
Query: 186 VSYDEAGTTCLIALLSDKDLTVANVGDSRGVL--CDKDG--NAIPLSHDHKPYQLKERKR 241
+ +G T +A + DL VAN GDSR +L ++DG +A+ LS+DH +E +R
Sbjct: 265 LRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELER 324
Query: 242 IK------RAGGFISFNGSWRVQGILAMSRSLGDYPLK-----NLNVVIPDPDIL----- 285
+K A + + R+ G+L R+ GD K V+ PD L
Sbjct: 325 LKLEHPKSEAKSVVKQD---RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEY 381
Query: 286 --------------------TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
T+ + Q +F++LA+DGLW+ ++ VR + E L H
Sbjct: 382 TKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH 441
Score = 30.0 bits (66), Expect = 3.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSV 162
+EDR T L +T + G+FDGH G ++ V RL + L +E + EN+V
Sbjct: 123 IEDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV 180
Query: 163 LSYQTIL 169
S + +L
Sbjct: 181 ESGRALL 187
>gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 55.8 bits (133), Expect = 6e-08
Identities = 63/240 (26%), Positives = 97/240 (40%), Gaps = 57/240 (23%)
Query: 126 IFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLT 185
+ D + GE+ VK L A K+ L LE Q+ L L
Sbjct: 244 LIDLNTGESTDIDVKEALINAFKR-------------LDNDISLEAQV-GDPNSFLNYLV 289
Query: 186 VSYDEAGTTCLIALLSDKDLTVANVGDSRGVL--CDKDG--NAIPLSHDHKPYQLKERKR 241
+ +G T +A + DL VAN GDSR +L ++DG +A+ LS+DH +E +R
Sbjct: 290 LRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELER 349
Query: 242 IK------RAGGFISFNGSWRVQGILAMSRSLGDYPLK-----NLNVVIPDPDIL----- 285
+K A + + R+ G+L R+ GD K V+ PD L
Sbjct: 350 LKLEHPKSEAKSVVKQD---RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEY 406
Query: 286 --------------------TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
T+ + Q +F++LA+DGLW+ ++ VR + E L H
Sbjct: 407 TKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH 466
Score = 30.0 bits (66), Expect = 3.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSV 162
+EDR T L +T + G+FDGH G ++ V RL + L +E + EN+V
Sbjct: 148 IEDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV 205
Query: 163 LSYQTIL 169
S + +L
Sbjct: 206 ESGRALL 212
>gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 55.8 bits (133), Expect = 6e-08
Identities = 63/240 (26%), Positives = 97/240 (40%), Gaps = 57/240 (23%)
Query: 126 IFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLT 185
+ D + GE+ VK L A K+ L LE Q+ L L
Sbjct: 244 LIDLNTGESTDIDVKEALINAFKR-------------LDNDISLEAQV-GDPNSFLNYLV 289
Query: 186 VSYDEAGTTCLIALLSDKDLTVANVGDSRGVL--CDKDG--NAIPLSHDHKPYQLKERKR 241
+ +G T +A + DL VAN GDSR +L ++DG +A+ LS+DH +E +R
Sbjct: 290 LRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELER 349
Query: 242 IK------RAGGFISFNGSWRVQGILAMSRSLGDYPLK-----NLNVVIPDPDIL----- 285
+K A + + R+ G+L R+ GD K V+ PD L
Sbjct: 350 LKLEHPKSEAKSVVKQD---RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEY 406
Query: 286 --------------------TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
T+ + Q +F++LA+DGLW+ ++ VR + E L H
Sbjct: 407 TKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH 466
Score = 30.0 bits (66), Expect = 3.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSV 162
+EDR T L +T + G+FDGH G ++ V RL + L +E + EN+V
Sbjct: 148 IEDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV 205
Query: 163 LSYQTIL 169
S + +L
Sbjct: 206 ESGRALL 212
>gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 1 [Homo sapiens]
Length = 596
Score = 55.8 bits (133), Expect = 6e-08
Identities = 63/240 (26%), Positives = 97/240 (40%), Gaps = 57/240 (23%)
Query: 126 IFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREMLEKLT 185
+ D + GE+ VK L A K+ L LE Q+ L L
Sbjct: 278 LIDLNTGESTDIDVKEALINAFKR-------------LDNDISLEAQV-GDPNSFLNYLV 323
Query: 186 VSYDEAGTTCLIALLSDKDLTVANVGDSRGVL--CDKDG--NAIPLSHDHKPYQLKERKR 241
+ +G T +A + DL VAN GDSR +L ++DG +A+ LS+DH +E +R
Sbjct: 324 LRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELER 383
Query: 242 IK------RAGGFISFNGSWRVQGILAMSRSLGDYPLK-----NLNVVIPDPDIL----- 285
+K A + + R+ G+L R+ GD K V+ PD L
Sbjct: 384 LKLEHPKSEAKSVVKQD---RLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEY 440
Query: 286 --------------------TFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPH 325
T+ + Q +F++LA+DGLW+ ++ VR + E L H
Sbjct: 441 TKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMH 500
Score = 30.0 bits (66), Expect = 3.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 4/67 (5%)
Query: 105 MEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEK--DKENSV 162
+EDR T L +T + G+FDGH G ++ V RL + L +E + EN+V
Sbjct: 182 IEDRRSAATCL--QTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV 239
Query: 163 LSYQTIL 169
S + +L
Sbjct: 240 ESGRALL 246
>gi|171460934 protein phosphatase 1M isoform b [Homo sapiens]
Length = 247
Score = 54.3 bits (129), Expect = 2e-07
Identities = 57/221 (25%), Positives = 92/221 (41%), Gaps = 70/221 (31%)
Query: 192 GTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKR------- 244
G T L+A+ L +AN GDSR +L +D PLS + P ER+RI++
Sbjct: 3 GCTALVAVSLQGKLYMANAGDSRAILVRRD-EIRPLSFEFTPET--ERQRIQQLAFVYPE 59
Query: 245 --AGGFISFN---------------------GSW----------------------RVQG 259
AG F W R+ G
Sbjct: 60 LLAGEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLG 119
Query: 260 ILAMSRSLGDYPLKNLNV-------VIPDPDILTFDLDKLQ---PEFMILASDGLWDAFS 309
LA+SR LGD+ L+ L+ ++ P + D+D+L+ + +++A+DGLWD S
Sbjct: 120 TLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLS 179
Query: 310 NEEAVRFIKERL----DEPH-FGAKSIVLQSFYRGCPDNIT 345
NE+ ++ L ++PH F + +L +G D++T
Sbjct: 180 NEQVAWLVRSFLPGNQEDPHRFSKLAQMLIHSTQGKEDSLT 220
>gi|149944715 protein phosphatase 1H (PP2C domain containing) [Homo
sapiens]
Length = 514
Score = 54.3 bits (129), Expect = 2e-07
Identities = 61/236 (25%), Positives = 98/236 (41%), Gaps = 71/236 (30%)
Query: 169 LEQQILSIDREMLEKLTVSYD-EAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPL 227
LE +D + +E+ SY+ G T LI + L VAN GDSR ++ ++G IP+
Sbjct: 245 LESAFKEMDLQ-IERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIII-RNGEIIPM 302
Query: 228 SHDHKPYQLKER---------------------------KRIKRAGGFISFNGS-W---- 255
S + P ++R K + + + FN + W
Sbjct: 303 SSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKT 362
Query: 256 ------------------RVQGILAMSRSLGDYPLK--NLNVVIPD-----PDILTFDLD 290
RV + ++R LGD+ LK + N+ I P++ +DL
Sbjct: 363 IEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLS 422
Query: 291 KLQ---PEFMILASDGLWDAFSNEEAVRFIKERL-----DEPH---FGAKSIVLQS 335
K + +ILA+DGLWD SNEE I + L D+PH A+ +V+++
Sbjct: 423 KYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRA 478
>gi|5174703 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform alpha [Homo sapiens]
Length = 504
Score = 46.2 bits (108), Expect = 5e-05
Identities = 60/262 (22%), Positives = 102/262 (38%), Gaps = 53/262 (20%)
Query: 96 YSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEAL---KQHLQ 152
YS G+ + ++ + ++G+F+G+ G +V RL L + + +
Sbjct: 37 YSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAE 96
Query: 153 DYEKDKENSVLSYQTILEQQIL-SIDREMLEKLTVSYD---------------------- 189
E D +L ++E+ L SID + EK ++
Sbjct: 97 HAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLK 156
Query: 190 ------EAGTTCLIALLSDKDLTVANVGDSRGVLCDK--DG-NAIPLSHDHKPYQLKERK 240
G ++A+L + L VANVG +R +LC DG L+ DH E
Sbjct: 157 TLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELF 216
Query: 241 RIKRAGGFISFNGSWRVQGILA---MSRSLGDYPLKN-------LNVVIPDPDILTFDLD 290
R+ + G G + GI+ +R +GDY +K L+ P I ++
Sbjct: 217 RLSQLG---LDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIH 273
Query: 291 KLQP-----EFMILASDGLWDA 307
QP F++L S+GL+ A
Sbjct: 274 GAQPLDGVTGFLVLMSEGLYKA 295
>gi|41281798 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform beta [Homo sapiens]
Length = 462
Score = 46.2 bits (108), Expect = 5e-05
Identities = 60/262 (22%), Positives = 102/262 (38%), Gaps = 53/262 (20%)
Query: 96 YSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEAL---KQHLQ 152
YS G+ + ++ + ++G+F+G+ G +V RL L + + +
Sbjct: 37 YSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAE 96
Query: 153 DYEKDKENSVLSYQTILEQQIL-SIDREMLEKLTVSYD---------------------- 189
E D +L ++E+ L SID + EK ++
Sbjct: 97 HAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLK 156
Query: 190 ------EAGTTCLIALLSDKDLTVANVGDSRGVLCDK--DG-NAIPLSHDHKPYQLKERK 240
G ++A+L + L VANVG +R +LC DG L+ DH E
Sbjct: 157 TLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELF 216
Query: 241 RIKRAGGFISFNGSWRVQGILA---MSRSLGDYPLKN-------LNVVIPDPDILTFDLD 290
R+ + G G + GI+ +R +GDY +K L+ P I ++
Sbjct: 217 RLSQLG---LDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIH 273
Query: 291 KLQP-----EFMILASDGLWDA 307
QP F++L S+GL+ A
Sbjct: 274 GAQPLDGVTGFLVLMSEGLYKA 295
>gi|65506328 protein phosphatase 1J (PP2C domain containing) [Homo
sapiens]
Length = 505
Score = 38.1 bits (87), Expect = 0.012
Identities = 38/160 (23%), Positives = 61/160 (38%), Gaps = 40/160 (25%)
Query: 124 FGIFDGHGGETAAEYVKSRLPEALKQHLQD------------------------------ 153
+G+FDGH G AAE L +++ L+D
Sbjct: 154 WGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDPSHL 213
Query: 154 ------YEKDKENSVLSYQT-ILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLT 206
+ KE S S +E +D +M + E G L+ + +
Sbjct: 214 LGPQSCWSSQKEVSHESLVVGAVENAFQLMDEQMARERRGHQVEGGCCALVVIYLLGKVY 273
Query: 207 VANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAG 246
VAN GDSR ++ ++G IP+S + P ER+R++ G
Sbjct: 274 VANAGDSRAIIV-RNGEIIPMSREFTPE--TERQRLQLLG 310
Score = 35.8 bits (81), Expect = 0.061
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 16/102 (15%)
Query: 256 RVQGILAMSRSLGDYPLKNLNVVIPD-------PDILTFDLDKLQ---PEFMILASDGLW 305
RV + ++R LGD+ LK + +P P++ +DL + + + ++L +DGLW
Sbjct: 372 RVMATIGVTRGLGDHSLKVCSSTLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLW 431
Query: 306 DAFSNEEAVRFIKERL------DEPHFGAKSIVLQSFYRGCP 341
D ++ E + L D + A + L RG P
Sbjct: 432 DVTTDCEVAATVDRVLSAYEPNDHSRYTALAQALVLGARGTP 473
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,472,625
Number of Sequences: 37866
Number of extensions: 515038
Number of successful extensions: 1544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 1406
Number of HSP's gapped (non-prelim): 73
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.