BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22 [Homo sapiens] (519 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 1064 0.0 gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 1006 0.0 gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 504 e-142 gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 496 e-140 gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 494 e-139 gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 489 e-138 gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 403 e-112 gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 402 e-112 gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 391 e-109 gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 389 e-108 gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 387 e-107 gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 387 e-107 gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 383 e-106 gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 234 2e-61 gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 148 1e-35 gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 142 6e-34 gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 140 3e-33 gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 139 5e-33 gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 139 5e-33 gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 110 2e-24 gi|5729796 cytochrome P450, family 46 [Homo sapiens] 109 5e-24 gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide... 109 5e-24 gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide... 109 5e-24 gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 107 2e-23 gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su... 106 4e-23 gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su... 106 4e-23 gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su... 106 4e-23 gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ... 102 1e-21 gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 100 3e-21 gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 100 5e-21 >gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22 [Homo sapiens] Length = 519 Score = 1064 bits (2752), Expect = 0.0 Identities = 519/519 (100%), Positives = 519/519 (100%) Query: 1 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF Sbjct: 1 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60 Query: 61 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY Sbjct: 61 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120 Query: 121 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 180 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD Sbjct: 121 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 180 Query: 181 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 240 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND Sbjct: 181 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 240 Query: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM Sbjct: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300 Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS Sbjct: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360 Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH Sbjct: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420 Query: 421 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL Sbjct: 421 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480 Query: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 519 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL Sbjct: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 519 >gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11 [Homo sapiens] Length = 519 Score = 1006 bits (2600), Expect = 0.0 Identities = 492/519 (94%), Positives = 502/519 (96%) Query: 1 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60 MSVSVLSPSR LG VSGILQ SLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF Sbjct: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60 Query: 61 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120 GHIQE Q DQELQRIQ+ V+TFPSACP+W+WGGKVRVQLYDPDYMKVILGRSDPKSHGSY Sbjct: 61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120 Query: 121 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 180 +FLAP IGYGLLLLNGQTWFQHRRMLTPAFH DILKPYVGLMADSVRVMLDKWEELLGQD Sbjct: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180 Query: 181 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 240 SPLEVFQHVSLMTLDTIMK AFSHQGSIQVDRNSQSYIQAISDLN+LVF +RNAFH+ND Sbjct: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240 Query: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM Sbjct: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300 Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGAS Sbjct: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360 Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH Sbjct: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420 Query: 421 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480 NPKVWPN EVFDP RFAPGSAQHSHAFLPFSGGSRNCIGKQFAMN+LKVA ALTLLRFEL Sbjct: 421 NPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480 Query: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 519 LPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL Sbjct: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519 >gi|30023836 cytochrome P450 4Z1 [Homo sapiens] Length = 505 Score = 504 bits (1297), Expect = e-142 Identities = 252/488 (51%), Positives = 344/488 (70%), Gaps = 4/488 (0%) Query: 24 LLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFP 83 LL + LLL + +LY R+W+++AL FP PP+HW +GH +EF +E + + ++ +P Sbjct: 19 LLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGH-KEFYPVKEFEVYHKLMEKYP 77 Query: 84 SACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHR 143 A P W+ + ++DPDY K++L R DPKS S+K L +G GL+ L+G W +HR Sbjct: 78 CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHR 137 Query: 144 RMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFS 203 +++ P F+ ILK ++ +M++SVR+ML+KWEE + Q+S LE+FQHVSLMTLD+IMK AFS Sbjct: 138 QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFS 197 Query: 204 HQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263 HQGSIQ+D SY++A+ +L+ + M N H ND ++ +S G+ + Q HQ T Sbjct: 198 HQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257 Query: 264 DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGH 323 ++VIQ RK L K+ + +KR DFLDILL AK EN S+ DL+AEV TFMF GH Sbjct: 258 EKVIQDRKESL-KDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGH 316 Query: 324 DTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLY 383 DTT+S ISWILY LA +P+HQ+RCR+EI LLGDG+SITW HL QMPYTTMCIKE LRLY Sbjct: 317 DTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLY 376 Query: 384 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ- 442 PV I R L P+TFPDGRSLP GI V ++I+ LHHNP W + +VF+P RF+ +++ Sbjct: 377 APVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEK 436 Query: 443 -HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNG 501 H +AF+PFS G RNCIG+ FA+ + KVA ALTLLRF+L PD +R P P+ ++VLKSKNG Sbjct: 437 IHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNG 496 Query: 502 IHLRLRRL 509 IH+ +++ Sbjct: 497 IHVFAKKV 504 >gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1 isoform b [Homo sapiens] Length = 511 Score = 496 bits (1276), Expect = e-140 Identities = 254/487 (52%), Positives = 319/487 (65%), Gaps = 3/487 (0%) Query: 25 LILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPS 84 LIL+L +K L L RQ L KA+ +FP PP+HWLFGH E Q L ++ FP Sbjct: 20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPY 79 Query: 85 ACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRR 144 A P W + +Y+PDY K + R DPK+ Y F IG GLL+L G W QHR+ Sbjct: 80 AHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRK 139 Query: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSH 204 +LTP FH D+LKPYV + +S R+MLDKWEE + ++F V M L+T+MK F Sbjct: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFG- 198 Query: 205 QGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTD 264 +G + SY A+SDL L+ + + + ND IY LT GR RACQ+AH HTD Sbjct: 199 RGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 258 Query: 265 QVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHD 324 QVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LSD DLRAEVDTFMFEGHD Sbjct: 259 QVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHD 318 Query: 325 TTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYP 384 TT SGISW LY +A +P+HQ RCREE+ +LGD W+ L +M Y TMCIKE+ RLYP Sbjct: 319 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 378 Query: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQ 442 PVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+ EVFD RF+ S + Sbjct: 379 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 438 Query: 443 HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGI 502 H AF+PFS G RNCIG+QFAM+++KV A+ LLRFE DP+R+PI M +LVL+SKNG Sbjct: 439 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGF 498 Query: 503 HLRLRRL 509 HL L+ L Sbjct: 499 HLHLKPL 505 >gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1 isoform a [Homo sapiens] Length = 512 Score = 494 bits (1271), Expect = e-139 Identities = 253/487 (51%), Positives = 317/487 (65%), Gaps = 2/487 (0%) Query: 25 LILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPS 84 LIL+L +K L L RQ L KA+ +FP PP+HWLFGH E Q L ++ FP Sbjct: 20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPY 79 Query: 85 ACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRR 144 A P W + +Y+PDY K + R DPK+ Y F IG GLL+L G W QHR+ Sbjct: 80 AHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRK 139 Query: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSH 204 +LTP FH D+LKPYV + +S R+MLDKWEE + ++F V M L+T+MK F Sbjct: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGR 199 Query: 205 QGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTD 264 + SY A+SDL L+ + + + ND IY LT GR RACQ+AH HTD Sbjct: 200 GDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 259 Query: 265 QVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHD 324 QVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LSD DLRAEVDTFMFEGHD Sbjct: 260 QVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHD 319 Query: 325 TTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYP 384 TT SGISW LY +A +P+HQ RCREE+ +LGD W+ L +M Y TMCIKE+ RLYP Sbjct: 320 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 379 Query: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQ 442 PVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+ EVFD RF+ S + Sbjct: 380 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 439 Query: 443 HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGI 502 H AF+PFS G RNCIG+QFAM+++KV A+ LLRFE DP+R+PI M +LVL+SKNG Sbjct: 440 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGF 499 Query: 503 HLRLRRL 509 HL L+ L Sbjct: 500 HLHLKPL 506 >gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1 [Homo sapiens] Length = 509 Score = 489 bits (1259), Expect = e-138 Identities = 241/486 (49%), Positives = 338/486 (69%), Gaps = 4/486 (0%) Query: 27 LLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSAC 86 L L L++A +LYL RQ LL+ L+ FP PP+HW GH Q+F D +++++E ++ +P A Sbjct: 22 LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGH-QKFIQDDNMEKLEEIIEKYPRAF 80 Query: 87 PYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRML 146 P+WI + +YDPDY K +L R+DPKS KF P +G GL L+G WFQHRR+L Sbjct: 81 PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140 Query: 147 TPAFHNDILKPYVGLMADSVRVMLDKWEELLG-QDSPLEVFQHVSLMTLDTIMKSAFSHQ 205 TP FH +ILK Y+ +MA SV++MLDKWE++ QD+ +EV++H++ M+LD IMK AFS + Sbjct: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200 Query: 206 GSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQ 265 + Q + Y +AI +L+ ++F + + + +D I+ L+ G + ++ +Q+TD Sbjct: 201 TNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDT 260 Query: 266 VIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDT 325 +IQ RK LQ + + ++++ DFLDI+L AK E+GS SD D+ +EV TF+ GHDT Sbjct: 261 IIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320 Query: 326 TASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPP 385 A+ ISWILY LA +P+HQERCREE+ G+LGDG+SITW+ L +M YTTMCIKE RL P Sbjct: 321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPA 380 Query: 386 VPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSA--QH 443 VP I R+LS P+TFPDG +LP GI V+LSI+GLHHNP VW N +VFDP RF+ ++ +H Sbjct: 381 VPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440 Query: 444 SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIH 503 +A+LPFS GSRNCIG++FAM +LKV AL LL F + PDPTR +LK KNG++ Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMY 500 Query: 504 LRLRRL 509 L L++L Sbjct: 501 LHLKKL 506 >gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3 [Homo sapiens] Length = 520 Score = 403 bits (1035), Expect = e-112 Identities = 228/503 (45%), Positives = 308/503 (61%), Gaps = 23/503 (4%) Query: 27 LLLLLIKAAQLYLH-RQWLLK------ALQQFPCPPS-HWLFGHIQEFQHDQE-LQRIQE 77 LLLLL+ A+ L W L+ FP PP +W GH+ +E L Q Sbjct: 20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQS 79 Query: 78 RVKTFPSACPYWIWGGKVRVQLYDPDYMKVIL---GRSDPKSHGSYKFLAPRIGYGLLLL 134 TF C +W+ V+++ P Y+K +L PK Y FL P +G GLLL Sbjct: 80 LACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLS 139 Query: 135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMT 193 G+ W +HRRMLTPAFH +ILKPY+ + +SV +M KW+ L + S L++F+H+SLMT Sbjct: 140 AGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMT 199 Query: 194 LDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253 LD++ K FS Q YI AI +L++LV + D +Y LT G+ Sbjct: 200 LDSLQKCVFSFDSHCQ--EKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFR 257 Query: 254 RACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKMENGSILSDKD 310 RAC+L H TD VIQ R+ L +G L+ + + LDF+D+LLL+K E+G LSD+D Sbjct: 258 RACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDED 317 Query: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD--GASITWNHLDQ 368 +RAE DTFMFEGHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W+ L Q Sbjct: 318 IRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQ 377 Query: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428 +P+ TMCIKE+LRL+PPVP + R + + PDGR +PKGI+ L+S++G HHNP VWP+ Sbjct: 378 LPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDP 437 Query: 429 EVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTR 486 EV+DP RF P + + AF+PFS G RNCIG+ FAM ++KV LTLLRF +LPD T Sbjct: 438 EVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTE 497 Query: 487 IPIPMARLVLKSKNGIHLRLRRL 509 P LVL+++ G+ LR+ L Sbjct: 498 -PRRKPELVLRAEGGLWLRVEPL 519 >gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2 [Homo sapiens] Length = 520 Score = 402 bits (1032), Expect = e-112 Identities = 229/513 (44%), Positives = 313/513 (61%), Gaps = 23/513 (4%) Query: 17 GILQVTSLLILLLLLIKAAQLYLH-RQWLL------KALQQFPCPPS-HWLFGHIQEFQH 68 G+ V + LLLLL+ A+ L H W + L+ FP PP +W +GH Sbjct: 10 GLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNP 69 Query: 69 DQELQRI-QERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYKFLA 124 +E R+ + V T+P W+ + L PD ++ ++ S PK Y FL Sbjct: 70 TEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLE 129 Query: 125 PRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-L 183 P +G GLLL G W +HRRMLTPAFH +ILKPY+ + +SV +M KW+ L + S L Sbjct: 130 PWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACL 189 Query: 184 EVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIY 243 ++F+H+SLMTLD++ K FS Q YI AI +L++LV D +Y Sbjct: 190 DMFEHISLMTLDSLQKCVFSFDSHCQ--EKPSEYIAAILELSALVSKRHHEILLHIDFLY 247 Query: 244 SLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKM 300 LT G+ RAC+L H TD VIQ R+ L +G L+ + + LDF+D+LLL+K Sbjct: 248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD 307 Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD--G 358 E+G LSD+D+RAE DTFMFEGHDTTASG+SW+LY LA HP++QERCR+E+ LL D Sbjct: 308 EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367 Query: 359 ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGL 418 I W+ L +P+ TMC+KE+LRL+PPVP I R ++ + PDGR +PKGI+ L+S++G Sbjct: 368 KEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGT 427 Query: 419 HHNPKVWPNLEVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLL 476 HHNP VWP+ EV+DP RF P + + AF+PFS G RNCIG+ FAM ++KV ALTLL Sbjct: 428 HHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLL 487 Query: 477 RFELLPDPTRIPIPMARLVLKSKNGIHLRLRRL 509 RF +LPD T P LVL+++ G+ LR+ L Sbjct: 488 RFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519 >gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8 [Homo sapiens] Length = 520 Score = 391 bits (1004), Expect = e-109 Identities = 222/503 (44%), Positives = 306/503 (60%), Gaps = 24/503 (4%) Query: 28 LLLLIKAAQLYLHR--QWLL------KALQQFPCP-PSHWLFGHIQEFQHDQE-LQRIQE 77 LLLL+ A L R W + L+ FP P +W GH+ +E L+ + + Sbjct: 20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQ 79 Query: 78 RVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDP---KSHGSYKFLAPRIGYGLLLL 134 V T+P W+ + L PD ++ ++ SD K YK L P +G GLLL Sbjct: 80 LVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLS 139 Query: 135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMT 193 G W HRR+LTPAFH +ILKPY+ + + S +M KW+ L + S L+VF+H+SLMT Sbjct: 140 VGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMT 199 Query: 194 LDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253 LD++ K FS + Q YI AI +L++LV F D +Y LT GR H Sbjct: 200 LDSLQKCIFSFDSNCQ--EKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH 257 Query: 254 RACQLAHQHTDQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAKMENGSILSDKD 310 RAC+L H TD VIQ R+ L +G L+ + + LDF+D+LLL++ +NG LSD+D Sbjct: 258 RACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDED 317 Query: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD--GASITWNHLDQ 368 +RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W+ L Q Sbjct: 318 IRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQ 377 Query: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428 +P+ TMC+KE+LRL+PP+P R + V PD R +PKG + ++I+ +HHNP VWP+ Sbjct: 378 LPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDP 437 Query: 429 EVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTR 486 EV+DP RF P +AQ AF+PFS G RNCIG++FAM ++KV ALTLLRF +LPD R Sbjct: 438 EVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPD-HR 496 Query: 487 IPIPMARLVLKSKNGIHLRLRRL 509 P +VL++++G+ LR+ L Sbjct: 497 EPRRTPEIVLRAEDGLWLRVEPL 519 >gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22 [Homo sapiens] Length = 531 Score = 389 bits (999), Expect = e-108 Identities = 221/510 (43%), Positives = 314/510 (61%), Gaps = 19/510 (3%) Query: 18 ILQVTSLLILLL-----LLIKAAQLYLHRQWLLKALQQFPCPPS-HWLFGHIQEF-QHDQ 70 I V++LL+ LL LL++ +L + L+ FP PP +WL GH+ + ++ Sbjct: 21 IYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEA 80 Query: 71 ELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYKFLAPRI 127 LQ ++ + W+ + L PDY+K +LG S PK Y FL P + Sbjct: 81 GLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWL 140 Query: 128 GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELL-GQDSPLEVF 186 G GLLL G W +HRR+LTPAFH DILKPY+ + S +M KW L G L++F Sbjct: 141 GDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMF 200 Query: 187 QHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT 246 +H+SLMTLD++ K FS+ + Q YI AI +L++L H D IY + Sbjct: 201 EHISLMTLDSLQKCVFSYNSNCQ--EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRS 258 Query: 247 SAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK--RHLDFLDILLLAKMENGS 304 + GR +AC + H T +VIQ R+ L+++G +K K + LDF+D+LLLA+ E+G Sbjct: 259 ADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGK 318 Query: 305 ILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG--DGASIT 362 LSD+D+RAE DTFMFEGHDTT+SGISW+L+ LA +P++QE+CREEI ++ + + Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378 Query: 363 WNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNP 422 W+ L Q+P+TTMCIKE+LR YPPV + R+ + + PDGR +PKGI+ L+SIYG HHNP Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438 Query: 423 KVWPNLEVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480 VWP+ +V++P RF P + Q A++PFS G RNCIG+ FAM +L+V ALTLLRF L Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498 Query: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLP 510 D TR L+L+++NG+ L++ LP Sbjct: 499 SVDRTRKVRRKPELILRTENGLWLKVEPLP 528 >gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11 [Homo sapiens] Length = 524 Score = 387 bits (993), Expect = e-107 Identities = 216/477 (45%), Positives = 296/477 (62%), Gaps = 16/477 (3%) Query: 46 KALQQFPCPPS-HWLFGHIQEFQHDQE-LQRIQERVKTFPSACPYWIWGGKVRVQLYDPD 103 + LQ FP PP +W +GH +E ++ + + V T+P W+ + L PD Sbjct: 46 RRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPD 105 Query: 104 YMKVILGRSD---PKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVG 160 ++ I S PK Y FL P +G GLLL G W +HRRMLTPAFH +ILKPY+ Sbjct: 106 IIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMK 165 Query: 161 LMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219 + SV +M DKW+ L + S L++F+H+SLMTLD++ K FS + + Q YI Sbjct: 166 IFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQ--EKPSEYIA 223 Query: 220 AISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE 279 AI +L++ V + D +Y LT G+ RAC L H TD VIQ R+ L +G Sbjct: 224 AILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI 283 Query: 280 LEKIKRK---RHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYA 336 + +K K + LDF+D+LLL+K E+G LSD+D+RAE DTFMFEGHDTTASG+SW+LY Sbjct: 284 DDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343 Query: 337 LATHPKHQERCREEIHGLLGD--GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELS 394 LA HP++QE+CR+E+ LL D I W+ L Q+P+ TMCIKE+LRL+PPVP I R + Sbjct: 344 LAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCT 403 Query: 395 TPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSH--AFLPFSG 452 PDGR +PKGI+ L++I G+H+NP VWP+ EV+DP RF + + AF+PFS Sbjct: 404 QDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSA 463 Query: 453 GSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRL 509 G RNCIG+ FAM ++KV ALTLL F +LP T P L+L+++ G+ LR+ L Sbjct: 464 GPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTE-PRRKPELILRAEGGLWLRVEPL 519 >gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11 [Homo sapiens] Length = 524 Score = 387 bits (993), Expect = e-107 Identities = 216/477 (45%), Positives = 296/477 (62%), Gaps = 16/477 (3%) Query: 46 KALQQFPCPPS-HWLFGHIQEFQHDQE-LQRIQERVKTFPSACPYWIWGGKVRVQLYDPD 103 + LQ FP PP +W +GH +E ++ + + V T+P W+ + L PD Sbjct: 46 RRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPD 105 Query: 104 YMKVILGRSD---PKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVG 160 ++ I S PK Y FL P +G GLLL G W +HRRMLTPAFH +ILKPY+ Sbjct: 106 IIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMK 165 Query: 161 LMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQ 219 + SV +M DKW+ L + S L++F+H+SLMTLD++ K FS + + Q YI Sbjct: 166 IFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQ--EKPSEYIA 223 Query: 220 AISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGE 279 AI +L++ V + D +Y LT G+ RAC L H TD VIQ R+ L +G Sbjct: 224 AILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI 283 Query: 280 LEKIKRK---RHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYA 336 + +K K + LDF+D+LLL+K E+G LSD+D+RAE DTFMFEGHDTTASG+SW+LY Sbjct: 284 DDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343 Query: 337 LATHPKHQERCREEIHGLLGD--GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELS 394 LA HP++QE+CR+E+ LL D I W+ L Q+P+ TMCIKE+LRL+PPVP I R + Sbjct: 344 LAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCT 403 Query: 395 TPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSH--AFLPFSG 452 PDGR +PKGI+ L++I G+H+NP VWP+ EV+DP RF + + AF+PFS Sbjct: 404 QDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSA 463 Query: 453 GSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRL 509 G RNCIG+ FAM ++KV ALTLL F +LP T P L+L+++ G+ LR+ L Sbjct: 464 GPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTE-PRRKPELILRAEGGLWLRVEPL 519 >gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12 [Homo sapiens] Length = 524 Score = 383 bits (983), Expect = e-106 Identities = 219/503 (43%), Positives = 306/503 (60%), Gaps = 22/503 (4%) Query: 26 ILLLLLIKAAQLYLHRQWLL------KALQQFPCPPS-HWLFGHIQEFQHDQE-LQRIQE 77 +LLLL++ + L W + LQ FP PP +W +GH+ +E L+ + Sbjct: 20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQ 79 Query: 78 RVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSD---PKSHGSYKFLAPRIGYGLLLL 134 T+ W+ + L PD ++ I S PK + +FL P +G G+LL Sbjct: 80 MSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLS 139 Query: 135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-LEVFQHVSLMT 193 G W +HRRMLTPAFH +ILK Y+ + S +MLDKW+ L + S L++F+H+SLMT Sbjct: 140 GGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMT 199 Query: 194 LDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253 LD++ K FS Q +R S+ YI I +L++LV ++ D +Y L+ GR H Sbjct: 200 LDSLQKCIFSFDSHCQ-ERPSE-YIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFH 257 Query: 254 RACQLAHQHTDQVIQLRKAQLQKEGELEKIKRK---RHLDFLDILLLAKMENGSILSDKD 310 RAC+L H TD VI+ R+ L +G + K K + LDF+D+LLL+K E+G LSD+D Sbjct: 258 RACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDED 317 Query: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL--GDGASITWNHLDQ 368 +RAE DTFMF GHDTTASG+SW+LY LA HP++QERCR+E+ LL D I W+ L Q Sbjct: 318 IRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQ 377 Query: 369 MPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNL 428 +P+ TMC+KE+LRL+PP P I R + + PDGR +PKGI L+ I G+HHNP VWP+ Sbjct: 378 LPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDP 437 Query: 429 EVFDPSRFAPGSAQHSH--AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTR 486 EV+DP RF P +++ AF+PFS G RNCIG+ FAM ++KV AL LL F LPD T Sbjct: 438 EVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE 497 Query: 487 IPIPMARLVLKSKNGIHLRLRRL 509 P L+++++ G+ LR+ L Sbjct: 498 -PRRKLELIMRAEGGLWLRVEPL 519 >gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2 [Homo sapiens] Length = 525 Score = 234 bits (596), Expect = 2e-61 Identities = 166/515 (32%), Positives = 268/515 (52%), Gaps = 28/515 (5%) Query: 12 LGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPP---SHWLFGHIQEFQH 68 L G + L + ++L LL + A R+W Q P P ++ L GH + Sbjct: 15 LWGAASALSLAGASLVLSLLQRVASYA--RKWQ----QMRPIPTVARAYPLVGHALLMKP 68 Query: 69 D--QELQRIQERVKTFPSACPYWIWGGKV-RVQLYDPDYMKVILGRSDPKSHGS-YKFLA 124 D + Q+I E + + +W G V V LY+ + ++VIL S S YKFL Sbjct: 69 DGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE 128 Query: 125 PRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLE 184 P +G GLL G W R+MLTP FH IL+ ++ +M + +++ K E+ + Q++ Sbjct: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-FN 187 Query: 185 VFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYS 244 F +++L LD I ++A Q + +S+ Y++A+ ++ ++F ++ + D Y Sbjct: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWYL 246 Query: 245 LTSAGRWTHR-ACQLAHQHTDQVIQLRKAQLQK------EGELEKIKRKRHLDFLDILLL 297 + G W H+ + Q+ H T+ VI R ++ +G + + FLD+LL Sbjct: 247 MFKEG-WEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLS 305 Query: 298 AKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG- 356 + G+ LS +D+R EVDTFMFEGHDTTA+ I+W LY L ++P+ Q++ E+ + G Sbjct: 306 VTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGK 365 Query: 357 DGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIY 416 T L ++ Y IKE LRL+P VP R +S R L KG ++ Y Sbjct: 366 SDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIPY 424 Query: 417 GLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALT 474 LH +P+ +PN E F P RF P +AQ H +A++PFS G RNCIG++FA+ + K + Sbjct: 425 ALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCI 484 Query: 475 LLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLRR 508 L F + + R + + +L+L+ NGI ++L+R Sbjct: 485 LRHFWIESNQKREELGLEGQLILRPSNGIWIKLKR 519 >gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] Length = 503 Score = 148 bits (374), Expect = 1e-35 Identities = 129/484 (26%), Positives = 224/484 (46%), Gaps = 37/484 (7%) Query: 28 LLLLIKAAQLYL---HRQWLLKALQQFPCPPSHWLFGHIQEFQH-----DQELQRIQERV 79 LLL + LYL H L K L P P G+I + D E + +V Sbjct: 13 LLLAVSLVLLYLYGTHSHGLFKKLG-IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71 Query: 80 KTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNG 136 F G + + + DPD +K +L + + + P +G+ + + Sbjct: 72 WGFYD-------GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKSAISIAED 123 Query: 137 QTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDT 196 + W + R +L+P F + LK V ++A V++ P+ + ++D Sbjct: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183 Query: 197 IMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRAC 256 I ++F + +D + + + L+ + F + T++ C Sbjct: 184 ITSTSFG----VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC 239 Query: 257 QLAHQHTDQVIQLRKA-QLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDL 311 + T+ LRK+ + KE LE ++ R +DFL +++ ++ E+ LSD +L Sbjct: 240 VFPREVTNF---LRKSVKRMKESRLEDTQKHR-VDFLQLMIDSQNSKETESHKALSDLEL 295 Query: 312 RAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPY 371 A+ F+F G++TT+S +S+I+Y LATHP Q++ +EEI +L + A T++ + QM Y Sbjct: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 Query: 372 TTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVF 431 M + E LRL+P + R V +G +PKG++V++ Y LH +PK W E F Sbjct: 356 LDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 Query: 432 DPSRFAPGSAQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIP 488 P RF+ + + + + PF G RNCIG +FA+ +K+A L F P T+IP Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 Query: 489 IPMA 492 + ++ Sbjct: 475 LKLS 478 >gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43 isoform 2 [Homo sapiens] Length = 503 Score = 142 bits (359), Expect = 6e-34 Identities = 108/432 (25%), Positives = 206/432 (47%), Gaps = 32/432 (7%) Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR--IGYGLLLLNGQTWFQHRRMLTPA 149 G + + + DPD +K +L + + L P + L + W + R +L+PA Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136 Query: 150 FHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209 F + K V +++ +++ + + + T+D I + F + Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192 Query: 210 VDRNSQSYIQAISDLNSLV-------FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262 +D + + ++ L+ F + + F ++ + G + + H Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249 Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318 + + ++++++L K K+K +DF ++ ++ ++ LSD +L A+ Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302 Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378 +F +DTT++ + +I+Y LATHP Q++ +EEI +L + A +T++ L QM Y M + E Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362 Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP 438 LRL+P V + R + +G +PKG+ V++ IY LHH+PK W E F P RF+ Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421 Query: 439 GSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPMARL- 494 + + ++PF G RNCIG +FA+ +K+A L F P T+IP+ + L Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481 Query: 495 VLKSKNGIHLRL 506 +L+ + I L++ Sbjct: 482 ILQPEKPIVLKV 493 >gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7 [Homo sapiens] Length = 503 Score = 140 bits (353), Expect = 3e-33 Identities = 109/417 (26%), Positives = 202/417 (48%), Gaps = 25/417 (5%) Query: 90 IWG----GKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNGQTWFQH 142 +WG + + + DPD +K +L + + + P +G+ + + + W + Sbjct: 71 VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGP-VGFMKNAISIAEDEEWKRI 129 Query: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202 R +L+P F + LK V ++A V++ P+ + ++D I ++F Sbjct: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSF 189 Query: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262 + +D + + + L+ + F + ++ + A + Sbjct: 190 G----VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP---ILEALNITVFP 242 Query: 263 TDQVIQLRKAQLQ-KEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDT 317 + L K+ Q KEG L++ ++ R +DFL +++ ++ E LSD +L A+ Sbjct: 243 RKVISFLTKSVKQIKEGRLKETQKHR-VDFLQLMIDSQNSKDSETHKALSDLELMAQSII 301 Query: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIK 377 F+F G++TT+S +S+I+Y LATHP Q++ ++EI +L + A T++ + Q+ Y M + Sbjct: 302 FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVN 361 Query: 378 EALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFA 437 E LRL+P + R V +G +PKG++V++ Y LHH+PK W E F P RF+ Sbjct: 362 ETLRLFPVAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420 Query: 438 PGSAQH--SHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPM 491 + + + + PF G RNCIG +FA+ +K+A L F P T+IP+ + Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477 >gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5 [Homo sapiens] Length = 502 Score = 139 bits (351), Expect = 5e-33 Identities = 109/415 (26%), Positives = 197/415 (47%), Gaps = 22/415 (5%) Query: 90 IWG---GKVRV-QLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNGQTWFQH 142 +WG G++ V + DPD ++ +L + + + L P +G+ + L + W + Sbjct: 71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-VGFMKSAISLAEDEEWKRI 129 Query: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202 R +L+P F + LK ++A V++ + P+ + ++D I ++F Sbjct: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189 Query: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262 + +D + + + + + ++ + A ++ Sbjct: 190 G----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP---VFEALNVSLFP 242 Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318 D + L K+ + + K+K LDFL +++ ++ E+ LSD +L A+ F Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378 +F G++TT+S +S+ LY LATHP Q++ ++EI +L + A T++ + QM Y M + E Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFA- 437 LRL+P + R V +G +PKG MV++ Y LHH+PK W E F P RF+ Sbjct: 363 TLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 Query: 438 PGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPM 491 + + + PF G RNCIG +FA+ +K+A L F P T+IP+ + Sbjct: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 >gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43 isoform 1 [Homo sapiens] Length = 504 Score = 139 bits (351), Expect = 5e-33 Identities = 109/433 (25%), Positives = 207/433 (47%), Gaps = 33/433 (7%) Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR--IGYGLLLLNGQTWFQHRRMLTPA 149 G + + + DPD +K +L + + L P + L + W + R +L+PA Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136 Query: 150 FHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209 F + K V +++ +++ + + + T+D I + F + Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192 Query: 210 VDRNSQSYIQAISDLNSLV-------FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262 +D + + ++ L+ F + + F ++ + G + + H Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249 Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318 + + ++++++L K K+K +DF ++ ++ ++ LSD +L A+ Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302 Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378 +F +DTT++ + +I+Y LATHP Q++ +EEI +L + A +T++ L QM Y M + E Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362 Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDP-SRFA 437 LRL+P V + R + +G +PKG+ V++ IY LHH+PK W E F P SRF+ Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421 Query: 438 PGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPMARL 494 + + ++PF G RNCIG +FA+ +K+A L F P T+IP+ + L Sbjct: 422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481 Query: 495 -VLKSKNGIHLRL 506 +L+ + I L++ Sbjct: 482 PILQPEKPIVLKV 494 >gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43 isoform 3 [Homo sapiens] Length = 420 Score = 110 bits (276), Expect = 2e-24 Identities = 85/357 (23%), Positives = 166/357 (46%), Gaps = 28/357 (7%) Query: 92 GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR--IGYGLLLLNGQTWFQHRRMLTPA 149 G + + + DPD +K +L + + L P + L + W + R +L+PA Sbjct: 77 GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136 Query: 150 FHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209 F + K V +++ +++ + + + T+D I + F + Sbjct: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192 Query: 210 VDRNSQSYIQAISDLNSLV-------FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262 +D + + ++ L+ F + + F ++ + G + + H Sbjct: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249 Query: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318 + + ++++++L K K+K +DF ++ ++ ++ LSD +L A+ Sbjct: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302 Query: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378 +F +DTT++ + +I+Y LATHP Q++ +EEI +L + A +T++ L QM Y M + E Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362 Query: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSR 435 LRL+P V + R + +G +PKG+ V++ IY LHH+PK W E F P R Sbjct: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418 >gi|5729796 cytochrome P450, family 46 [Homo sapiens] Length = 500 Score = 109 bits (273), Expect = 5e-24 Identities = 93/363 (25%), Positives = 164/363 (45%), Gaps = 28/363 (7%) Query: 128 GYGLLL-LNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVF 186 G GL+ N + W + RR++ AF L + + +++ E +P+ + Sbjct: 122 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQ 181 Query: 187 QHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLT 246 ++ +D + K+AF + S+ + A L+ V + +T+ Sbjct: 182 DMLTYTAMDILAKAAFGMETSM--------LLGAQKPLSQAVKLMLEGITASRNTLAKFL 233 Query: 247 SAGRWTHRACQLAHQHTDQV----IQLRKAQLQKEGELEKIKRKRHLDFLDILL-LAKME 301 R R + + + QV +Q R+ L++ E+ DIL + K E Sbjct: 234 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------DILTQILKAE 283 Query: 302 NGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASI 361 G+ D+ L TF GH+T+A+ +++ + L+ P+ R + E+ ++G + Sbjct: 284 EGA-QDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 342 Query: 362 TWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHN 421 + L ++ Y + +KE+LRLYPP G R L T DG +P +L S Y + Sbjct: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRM 401 Query: 422 PKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKV--ARALTLLRFE 479 + + F+P RF PG+ + + PFS G R+CIG+QFA ++KV A+ L L F Sbjct: 402 DTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461 Query: 480 LLP 482 L+P Sbjct: 462 LVP 464 >gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1 isoform 2 [Homo sapiens] Length = 428 Score = 109 bits (273), Expect = 5e-24 Identities = 101/354 (28%), Positives = 164/354 (46%), Gaps = 30/354 (8%) Query: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185 +G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V Sbjct: 51 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 108 Query: 186 FQHVSLMTLDTIMKSAFSHQGSIQVDRNS-QSYIQAISDLNSLVFCCMRNAFH-ENDTIY 243 + V + M+ + + D +S Q ++A ++ RN F D + Sbjct: 109 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT-------RNLFSLPIDVPF 161 Query: 244 SLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENG 303 S G +A L H +Q I+ + L+ + K D L +L+ E G Sbjct: 162 SGLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERG 213 Query: 304 SILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEI--HGLL---GDG 358 L + L+ +F GH+TTAS + ++ L +P ++ REE+ GLL Sbjct: 214 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 273 Query: 359 ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGL 418 + L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI Sbjct: 274 NKLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDT 332 Query: 419 HHNPKVWPNLEVFDPSRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKV 469 H +++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+ Sbjct: 333 HDVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKI 385 >gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1 isoform 1 [Homo sapiens] Length = 497 Score = 109 bits (273), Expect = 5e-24 Identities = 101/354 (28%), Positives = 164/354 (46%), Gaps = 30/354 (8%) Query: 127 IGYGLLL-LNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEV 185 +G G L L+ + Q ++++ AF + L+ YV ++ + V L++W L + L V Sbjct: 120 LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLV 177 Query: 186 FQHVSLMTLDTIMKSAFSHQGSIQVDRNS-QSYIQAISDLNSLVFCCMRNAFH-ENDTIY 243 + V + M+ + + D +S Q ++A ++ RN F D + Sbjct: 178 YPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT-------RNLFSLPIDVPF 230 Query: 244 SLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENG 303 S G +A L H +Q I+ + L+ + K D L +L+ E G Sbjct: 231 SGLYRGM---KARNLIHARIEQNIRAKICGLRASEAGQGCK-----DALQLLIEHSWERG 282 Query: 304 SILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEI--HGLL---GDG 358 L + L+ +F GH+TTAS + ++ L +P ++ REE+ GLL Sbjct: 283 ERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQD 342 Query: 359 ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGL 418 + L+Q+ Y IKE LRL PPVPG G ++ +G +PKG V+ SI Sbjct: 343 NKLDMEILEQLKYIGCVIKETLRLNPPVPG-GFRVALKTFELNGYQIPKGWNVIYSICDT 401 Query: 419 HHNPKVWPNLEVFDPSRFA---PGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKV 469 H +++ N E F+P RF P A +F+PF GG R+C+GK+FA LK+ Sbjct: 402 HDVAEIFTNKEEFNPDRFMLPHPEDASR-FSFIPFGGGLRSCVGKEFAKILLKI 454 >gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1 [Homo sapiens] Length = 508 Score = 107 bits (268), Expect = 2e-23 Identities = 69/204 (33%), Positives = 101/204 (49%), Gaps = 5/204 (2%) Query: 306 LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASI--TW 363 L + + V + G DT ++ +SW LY L+ HP+ Q EI L G+S + Sbjct: 302 LPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSA 361 Query: 364 NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPK 423 L Q+P +KE LRLYP VPG R + D +PK +V L Y +P Sbjct: 362 TVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGD-YIIPKNTLVTLCHYATSRDPA 420 Query: 424 VWPNLEVFDPSRF-APGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 482 +P F P+R+ G H A LPF G R+C+G++ A +L++A A L FE+ P Sbjct: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480 Query: 483 DPTRIPI-PMARLVLKSKNGIHLR 505 +P P+ P R VL + I+L+ Sbjct: 481 EPGAAPVRPKTRTVLVPERSINLQ 504 >gi|239757171 PREDICTED: similar to cytochrome P450, family 4, subfamily F, polypeptide 2 [Homo sapiens] Length = 190 Score = 106 bits (265), Expect = 4e-23 Identities = 64/168 (38%), Positives = 97/168 (57%), Gaps = 7/168 (4%) Query: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKSAFS 203 ML PAFH +ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ K FS Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60 Query: 204 HQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263 Q YI ++ +L+SLV + D +Y LT GR HRAC+L H Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118 Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307 D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166 >gi|239751683 PREDICTED: similar to cytochrome P450, family 4, subfamily F, polypeptide 2 [Homo sapiens] Length = 190 Score = 106 bits (265), Expect = 4e-23 Identities = 64/168 (38%), Positives = 97/168 (57%), Gaps = 7/168 (4%) Query: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKSAFS 203 ML PAFH +ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ K FS Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60 Query: 204 HQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263 Q YI ++ +L+SLV + D +Y LT GR HRAC+L H Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118 Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307 D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166 >gi|239746187 PREDICTED: similar to cytochrome P450, family 4, subfamily F, polypeptide 2 [Homo sapiens] Length = 190 Score = 106 bits (265), Expect = 4e-23 Identities = 64/168 (38%), Positives = 97/168 (57%), Gaps = 7/168 (4%) Query: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEEL-LGQDSPLEVFQHVSLMTLDTIMKSAFS 203 ML PAFH +ILKPY+ + +SV +M KW L L ++ L++F+H++LMTLD++ K FS Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60 Query: 204 HQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT 263 Q YI ++ +L+SLV + D +Y LT GR HRAC+L H Sbjct: 61 FDSQCQ--EKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118 Query: 264 DQVIQLRKAQLQKEGE---LEKIKRKRHLDFLDILLLAK-MENGSILS 307 D IQ ++ L +G L+ + + LDF+D+LL++K M G ++S Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLLISKAMTPGPVVS 166 >gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1 [Homo sapiens] Length = 512 Score = 102 bits (253), Expect = 1e-21 Identities = 77/243 (31%), Positives = 122/243 (50%), Gaps = 22/243 (9%) Query: 265 QVIQ--LRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEG 322 Q++Q L KA +K L+ + K +LD LD+L+ + E+G ++ ++L+ +F Sbjct: 241 QILQKGLEKAIREK---LQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAA 297 Query: 323 HDTTASGISWILYALATHPKHQERCREEI--HGLLGDG-----ASITWNHLDQMPYTTMC 375 + TTAS + ++ L HP E+ R+E+ HG+L G ++ + L + Y Sbjct: 298 YATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCV 357 Query: 376 IKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSR 435 IKE +RL+ P+ G R + DG +PKG V+ SI H V+ ++ VFDP R Sbjct: 358 IKEVMRLFTPISGGYRTVLQTFEL-DGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDR 416 Query: 436 FAPGSAQHSHA---FLPFSGGSRNCIGKQFAMNQLKV--ARALTLLRFEL----LPDPTR 486 F+ ++ +LPF GG R C+GK A LKV + RFEL P T Sbjct: 417 FSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITL 476 Query: 487 IPI 489 +P+ Sbjct: 477 VPV 479 >gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1 [Homo sapiens] Length = 544 Score = 100 bits (249), Expect = 3e-21 Identities = 65/224 (29%), Positives = 107/224 (47%), Gaps = 8/224 (3%) Query: 281 EKIKRKRHLDFLDILLL-----AKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILY 335 E + R+ DF+D+ LL K + S ++ L + G DTT + + W L Sbjct: 307 ESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLL 366 Query: 336 ALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELST 395 ++ +P QE+ EEI ++G + + QMPYT I E RL VP +++ Sbjct: 367 YMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTS 426 Query: 396 PVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGG 453 T G ++PKG ++L +++ +H +P +W E F P+RF Q F+PF G Sbjct: 427 ENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIG 486 Query: 454 SRNCIGKQFAMNQLKVARALTLLRFEL-LPDPTRIPIPMARLVL 496 R C+G+Q A +L + + F LP+ ++ P+ R L Sbjct: 487 KRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGL 530 >gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo sapiens] Length = 534 Score = 99.8 bits (247), Expect = 5e-21 Identities = 58/195 (29%), Positives = 106/195 (54%), Gaps = 8/195 (4%) Query: 318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQ-MPYTTMCI 376 F+ G++ + +S+ Y LAT+P QE+ E+ + + L++ +PY M I Sbjct: 339 FLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVI 398 Query: 377 KEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRF 436 E LR+YPP RE + G+ +P G ++ +++ LHH+P+ WP+ E F+P RF Sbjct: 399 AETLRMYPPAFRFTREAAQDCEVL-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF 457 Query: 437 APGSAQHSHAF--LPFSGGSRNCIGKQFAMNQLKVA--RALTLLRFELLPDPTRIPIPM- 491 + Q F LPF G R+C+G + + ++K+ L RF+ P+ T++P+ + Sbjct: 458 TAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPE-TQVPLQLE 516 Query: 492 ARLVLKSKNGIHLRL 506 ++ L KNG+++++ Sbjct: 517 SKSALGPKNGVYIKI 531 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.139 0.433 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,802,313 Number of Sequences: 37866 Number of extensions: 948547 Number of successful extensions: 2268 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 72 Number of HSP's successfully gapped in prelim test: 8 Number of HSP's that attempted gapping in prelim test: 2002 Number of HSP's gapped (non-prelim): 93 length of query: 519 length of database: 18,247,518 effective HSP length: 107 effective length of query: 412 effective length of database: 14,195,856 effective search space: 5848692672 effective search space used: 5848692672 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.