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Search of human proteins with 62952502
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62952502 cytochrome P450, family 26, subfamily C,
polypeptide 1 [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide... 1050 0.0
gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide ... 534 e-152
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide... 393 e-109
gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide... 347 2e-95
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 105 8e-23
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 101 2e-21
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 96 6e-20
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 91 3e-18
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 88 2e-17
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 86 1e-16
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 84 4e-16
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 83 5e-16
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 82 1e-15
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 82 1e-15
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 79 8e-15
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 76 7e-14
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 75 1e-13
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 75 2e-13
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 74 2e-13
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 73 6e-13
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 73 6e-13
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 73 7e-13
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 73 7e-13
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 73 7e-13
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 73 7e-13
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 72 2e-12
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 71 2e-12
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 70 4e-12
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 70 4e-12
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 69 8e-12
>gi|62952502 cytochrome P450, family 26, subfamily C, polypeptide 1
[Homo sapiens]
Length = 522
Score = 1050 bits (2715), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60
MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG
Sbjct: 1 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60
Query: 61 ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS 120
ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS
Sbjct: 61 ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS 120
Query: 121 AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS 180
AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS
Sbjct: 121 AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS 180
Query: 181 VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR 240
VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR
Sbjct: 181 VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR 240
Query: 241 DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT 300
DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT
Sbjct: 241 DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT 300
Query: 301 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL 360
TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL
Sbjct: 301 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL 360
Query: 361 AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV 420
AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV
Sbjct: 361 AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV 420
Query: 421 YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA 480
YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA
Sbjct: 421 YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA 480
Query: 481 RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL 522
RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL
Sbjct: 481 RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL 522
>gi|9845285 cytochrome P450, family 26, subfamily b, polypeptide 1
[Homo sapiens]
Length = 512
Score = 534 bits (1375), Expect = e-152
Identities = 266/507 (52%), Positives = 359/507 (70%), Gaps = 18/507 (3%)
Query: 5 GLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLH 64
GL +S L L+ LLL+++Q LW LRW +RD++ LP+PKGSMG+P GET H
Sbjct: 5 GLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGH 64
Query: 65 WLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHIL 124
WL+QGS F SSRRE+YG VFKTHLLGRP+IRV+GAENVR IL+GEH LV ++WP+S +L
Sbjct: 65 WLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRML 124
Query: 125 LGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDA 184
LG +T+ ++G+ HR +RKV +++FS ALE Y+P++Q ++ +R+W + ++VY
Sbjct: 125 LGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQE 184
Query: 185 SKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLH 244
++ LTFRMA R+LLG + E L ++Q V+N+FSLP+D+PFSG R+GI+AR L
Sbjct: 185 AQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQ 244
Query: 245 RHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASA 304
+ LE AI EKL + + DALDL+I S++E G E +MQELK+ +EL+FAA+ TTASA
Sbjct: 245 KGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASA 304
Query: 305 STSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALG 364
STSL++ LL+HP + K+R+EL A G+ + GC CE L L L
Sbjct: 305 STSLIMQLLKHPTVLEKLRDELRAHGILHSGGCP---------------CEGTLRLDTLS 349
Query: 365 RLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSP 424
LRY+DCV+KEV+RL P+SGGYRT L+TFELDG+QIPKGWSVMYSIRDTH+TA V++
Sbjct: 350 GLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKD- 408
Query: 425 PEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL 484
FDP+RF AR + + RFHY+PFGGG R+CLG+ LA+ L++LAVEL T+R+EL
Sbjct: 409 VNVFDPDRFSQARSEDK--DGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFEL 466
Query: 485 ATPAFPAMQTVPIVHPVDGLRLFFHPL 511
AT FP + VP++HPVDGL + F L
Sbjct: 467 ATRTFPRITLVPVLHPVDGLSVKFFGL 493
>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 497
Score = 393 bits (1010), Expect = e-109
Identities = 226/506 (44%), Positives = 305/506 (60%), Gaps = 35/506 (6%)
Query: 10 SVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQG 69
++L +A + LL A LW L + RDR+ LPLP G+MG+PFFGETL ++Q
Sbjct: 5 ALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQR 64
Query: 70 SRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHT 129
+F +R +YG ++KTHL GRP +RV GA+NVR ILLGEHRLV WP S +LGS
Sbjct: 65 RKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGC 124
Query: 130 LLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAG-GPVSVYDASKAL 188
L H++R+KV+ R FSR ALE YVP + + + W + G + VY K L
Sbjct: 125 LSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRL 184
Query: 189 TFRMAARILLG----LRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLH 244
FR+A RILLG L D L FE++ NLFSLP+DVPFSGL +G++AR+ +H
Sbjct: 185 MFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIH 244
Query: 245 RHLEGAISEKLHEDKAAEPG----DALDLIIHSARELGHEPSMQELKESAVELLFAAFFT 300
+E I K+ +A+E G DAL L+I + E G MQ LK+S+ ELLF T
Sbjct: 245 ARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHET 304
Query: 301 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPD--L 358
TASA+TSL+ L +P + K+REEL ++GL C D L
Sbjct: 305 TASAATSLITYLGLYPHVLQKVREELKSKGL-------------------LCKSNQDNKL 345
Query: 359 SLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETA 418
+ L +L+Y+ CV+KE LRL PPV GG+R AL+TFEL+GYQIPKGW+V+YSI DTH+ A
Sbjct: 346 DMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVA 405
Query: 419 AVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVR 478
++ + E F+P+RF + +SRF +IPFGGG RSC+G+E A+ +L++ VEL R
Sbjct: 406 EIFTNKEE-FNPDRFMLPHPED---ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461
Query: 479 TARWELATPAFPAMQTVPIVHPVDGL 504
W+L P M+T P V+PVD L
Sbjct: 462 HCDWQLLNGP-PTMKTSPTVYPVDNL 486
>gi|16933528 cytochrome P450, family 26, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 428
Score = 347 bits (889), Expect = 2e-95
Identities = 199/440 (45%), Positives = 267/440 (60%), Gaps = 35/440 (7%)
Query: 76 RRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVG 135
+R +YG ++KTHL GRP +RV GA+NVR ILLGEHRLV WP S +LGS L
Sbjct: 2 KRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHD 61
Query: 136 EPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAG-GPVSVYDASKALTFRMAA 194
H++R+KV+ R FSR ALE YVP + + + W + G + VY K L FR+A
Sbjct: 62 SSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAM 121
Query: 195 RILLG----LRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLHRHLEGA 250
RILLG L D L FE++ NLFSLP+DVPFSGL +G++AR+ +H +E
Sbjct: 122 RILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQN 181
Query: 251 ISEKLHEDKAAEPG----DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASAST 306
I K+ +A+E G DAL L+I + E G MQ LK+S+ ELLF TTASA+T
Sbjct: 182 IRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAAT 241
Query: 307 SLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPD--LSLAALG 364
SL+ L +P + K+REEL ++GL C D L + L
Sbjct: 242 SLITYLGLYPHVLQKVREELKSKGL-------------------LCKSNQDNKLDMEILE 282
Query: 365 RLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSP 424
+L+Y+ CV+KE LRL PPV GG+R AL+TFEL+GYQIPKGW+V+YSI DTH+ A ++ +
Sbjct: 283 QLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNK 342
Query: 425 PEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL 484
E F+P+RF + +SRF +IPFGGG RSC+G+E A+ +L++ VEL R W+L
Sbjct: 343 EE-FNPDRFMLPHPED---ASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQL 398
Query: 485 ATPAFPAMQTVPIVHPVDGL 504
P M+T P V+PVD L
Sbjct: 399 LNGP-PTMKTSPTVYPVDNL 417
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 105 bits (263), Expect = 8e-23
Identities = 118/478 (24%), Positives = 202/478 (42%), Gaps = 53/478 (11%)
Query: 57 PFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGE-HRLVRS 115
PF G L +L F E+YG ++ + +P++ + + ++T+L+ E + + +
Sbjct: 45 PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN 104
Query: 116 QWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGA---LRHEVRSW 172
Q P L S L A E +R R +L+ F+ + VP + L +R
Sbjct: 105 QMPLGPMGFLKS-ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE 163
Query: 173 CAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCAT--LARTFEQLVENLFSLP----- 225
+++ D A T + L G+ LD + ++L++ F P
Sbjct: 164 AENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI 223
Query: 226 -----LDVPFSGLRKGIRARDQLHRHLEGAIS---EKLHEDKAAEPGDALDLIIHS--AR 275
L F L G+ +D H L+ +I E +DK D +I S ++
Sbjct: 224 SLFPFLTPVFEALNIGLFPKDVTH-FLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSK 282
Query: 276 ELGHEPSMQELK--ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGR 333
E ++ +L+ ++ ++FAA+ TT++ ++ L HP K++EE+ A +
Sbjct: 283 ETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK 342
Query: 334 ACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRT 393
A ++ AL ++ Y+D VV E LRL P VS R +
Sbjct: 343 A----------------------PVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKD 380
Query: 394 FELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFG 453
E++G IPKG +VM I H Y + PE F PERF +DS + YIPFG
Sbjct: 381 IEINGVFIPKGLAVMVPIYALHHDPK-YWTEPEKFCPERFSKKNKDS---IDLYRYIPFG 436
Query: 454 GGARSCLGQELAQAVLQLLAVELVRTARWE--LATPAFPAMQTVPIVHPVDGLRLFFH 509
G R+C+G A ++L + ++ ++ T + +PI+ P + L H
Sbjct: 437 AGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVH 494
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 101 bits (251), Expect = 2e-21
Identities = 118/479 (24%), Positives = 202/479 (42%), Gaps = 54/479 (11%)
Query: 57 PFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGE-HRLVRS 115
PF G L +L F E+YG ++ + +P++ + + ++T+L+ E + + +
Sbjct: 45 PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN 104
Query: 116 QWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGA---LRHEVRSW 172
Q P L S L A E +R R +L+ F+ + VP + L +R
Sbjct: 105 QMPLGPMGFLKS-ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE 163
Query: 173 CAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCAT--LARTFEQLVENLFSLP----- 225
+++ D A T + L G+ LD + ++L++ F P
Sbjct: 164 AENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI 223
Query: 226 -----LDVPFSGLRKGIRARDQLHRHLEGAIS---EKLHEDKAAEPGDALDLIIHS--AR 275
L F L G+ +D H L+ +I E +DK D +I S ++
Sbjct: 224 SLFPFLTPVFEALNIGLFPKDVTH-FLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSK 282
Query: 276 ELGHEPSMQELK--ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGR 333
E ++ +L+ ++ ++FAA+ TT++ ++ L HP K++EE+ A +
Sbjct: 283 ETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK 342
Query: 334 ACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRT 393
A ++ AL ++ Y+D VV E LRL P VS R +
Sbjct: 343 A----------------------PVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKD 380
Query: 394 FELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPE-RFGAAREDSRGASSRFHYIPF 452
E++G IPKG +VM I H Y + PE F PE RF +DS + YIPF
Sbjct: 381 IEINGVFIPKGLAVMVPIYALHHDPK-YWTEPEKFCPESRFSKKNKDS---IDLYRYIPF 436
Query: 453 GGGARSCLGQELAQAVLQLLAVELVRTARWE--LATPAFPAMQTVPIVHPVDGLRLFFH 509
G G R+C+G A ++L + ++ ++ T + +PI+ P + L H
Sbjct: 437 GAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVH 495
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 96.3 bits (238), Expect = 6e-20
Identities = 122/498 (24%), Positives = 199/498 (39%), Gaps = 81/498 (16%)
Query: 11 VLGAAGTALLCAG--LLLSLAQHL--WTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWL 66
+L A +AL AG L+LSL Q + + +W R P+P + +P G L
Sbjct: 14 LLWGAASALSLAGASLVLSLLQRVASYARKWQQMR------PIPTVARAYPLVGHALLMK 67
Query: 67 VQGSRFHSSRRE-----RYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSA 121
G F E R+ + K + P++ + AENV IL ++ +S +
Sbjct: 68 PDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFL 127
Query: 122 HILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERY-----------VPRLQGALRHEVR 170
LG LL + G R RRK+L F LE + V +L+ + E
Sbjct: 128 EPWLGLG-LLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAF 186
Query: 171 SWCAAGGPVSVYD--ASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLP--- 225
+ C + D A+ + A+ D+++ +++ +P
Sbjct: 187 N-CFFYITLCALDIICETAMGKNIGAQ-----SNDDSEYVRAVYRMSEMIFRRIKMPWLW 240
Query: 226 LDVPFSGLRKGIRARDQL---HRHLEGAISEKLHEDKAAEP--GDA-------------L 267
LD+ + ++G + L H I+E+ +E A E GD L
Sbjct: 241 LDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL 300
Query: 268 DLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELV 327
DL++ + G+ S ++++E +F TTA+A + LL +P K+ EL
Sbjct: 301 DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL- 359
Query: 328 AQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGY 387
G S+ P ++ L +LRY++CV+KE LRL P V
Sbjct: 360 -----------DDVFGKSDRPA---------TVEDLKKLRYLECVIKETLRLFPSVPLFA 399
Query: 388 RTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRF 447
R+ E+ GY++ KG + H + +P E F PERF R +
Sbjct: 400 RSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEE-FQPERFFPENAQGR---HPY 455
Query: 448 HYIPFGGGARSCLGQELA 465
Y+PF G R+C+GQ+ A
Sbjct: 456 AYVPFSAGPRNCIGQKFA 473
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 90.5 bits (223), Expect = 3e-18
Identities = 113/481 (23%), Positives = 189/481 (39%), Gaps = 58/481 (12%)
Query: 24 LLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTV 83
LLL+++ L L S L +P G PF G L + F ++YG V
Sbjct: 13 LLLAVSLVLLYLYGTHSHGLFKKLGIP-GPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71
Query: 84 FKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRK 143
+ + +PV+ ++ + ++T+L+ E V + + + A E +R R
Sbjct: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131
Query: 144 VLARVFSRAALERYVPRLQ---GALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGL 200
+L+ F+ L+ VP + L +R G PV++ D A + + G+
Sbjct: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191
Query: 201 RLDEAQCATLARTFEQLVENLFSL----------------PLDVPFSGLRKGIRARDQLH 244
+D +L + VEN L P +P + ++
Sbjct: 192 NID-----SLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246
Query: 245 RHLEGAIS---EKLHEDKAAEPGDALDLIIHSARELGHEP----SMQELKESAVELLFAA 297
L ++ E ED D L L+I S E S EL ++ +FA
Sbjct: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306
Query: 298 FFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPD 357
+ TT+S + ++ L HP K++EE+ A ++ PP
Sbjct: 307 YETTSSVLSFIMYELATHPDVQQKLQEEI-------------DAVLPNKAPP-------- 345
Query: 358 LSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHET 417
+ + ++ Y+D VV E LRL P R + E++G IPKG VM H
Sbjct: 346 -TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404
Query: 418 AAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELV 477
Y + PE F PERF +D+ + Y PFG G R+C+G A ++L + ++
Sbjct: 405 PK-YWTEPEKFLPERFSKKNKDN---IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460
Query: 478 R 478
+
Sbjct: 461 Q 461
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 87.8 bits (216), Expect = 2e-17
Identities = 110/476 (23%), Positives = 193/476 (40%), Gaps = 49/476 (10%)
Query: 24 LLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTV 83
LLL+++ L L + L +P G P G L + +F + ++YG +
Sbjct: 13 LLLAVSLVLLYLYGTRTHGLFKRLGIP-GPTPLPLLGNVLSYRQGLWKFDTECYKKYGKM 71
Query: 84 FKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRK 143
+ T+ PV+ ++ + +RT+L+ E V + + + A E +R R
Sbjct: 72 WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRS 131
Query: 144 VLARVFSRAALERYVPRLQ---GALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGL 200
+L+ F+ L+ P + L +R G PV++ D A + + G+
Sbjct: 132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191
Query: 201 RLD----------EAQCATLARTF-EQLVENLFSLPLDVP-FSGLRKGIRARDQLHRHLE 248
+D E+ L F + L ++ P P F L + +D ++ +
Sbjct: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251
Query: 249 GA--ISEKLHEDKAAEPGDALDLIIHSARELGHEP----SMQELKESAVELLFAAFFTTA 302
+ + DK D L L+I S E S EL ++ +FA + TT+
Sbjct: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311
Query: 303 SASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAA 362
S + + L HP K+++E+ A ++ PP + A
Sbjct: 312 SVLSFTLYELATHPDVQQKLQKEI-------------DAVLPNKAPP---------TYDA 349
Query: 363 LGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYR 422
+ ++ Y+D VV E LRL P RT + E++G IPKG V+ H Y
Sbjct: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK-YW 408
Query: 423 SPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVR 478
+ PE F PERF ++ + + Y PFG G R+C+G A ++L + +++
Sbjct: 409 TEPEEFRPERFSKKKD----SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 85.5 bits (210), Expect = 1e-16
Identities = 100/449 (22%), Positives = 197/449 (43%), Gaps = 66/449 (14%)
Query: 78 ERYGTVFKTHLLGRPVIRVSGAENVRTILLGE------------HRLVRSQWPQSAHILL 125
+++G +++ HL + V+ ++ + ++ + ++LV +P + L
Sbjct: 54 QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPD---LSL 110
Query: 126 GSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDAS 185
G ++LL + H++ + + R ++E V +L +R+ G PV++ +
Sbjct: 111 GDYSLLW---KAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRA--QPGTPVAIEEEF 165
Query: 186 KALTFRMAARILLGLRL-DEAQCATLARTFEQLVENLFSLPLDV----------PFSGLR 234
LT + + G ++ D+ + +++++ + + P GLR
Sbjct: 166 SLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLR 225
Query: 235 KGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKE-----S 289
+ +A ++ +E + + A + D +D ++ + E +L E +
Sbjct: 226 RLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMA 285
Query: 290 AVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPP 349
AV+LL TTA+ + V+ LL HP +++EEL + PGA+ S P
Sbjct: 286 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE-------LGPGASS-SRVPY 337
Query: 350 PDCGCEPDLSLAALGRLRYVDCVVKEVLRLLP--PVSGGYRTALRTFELDGYQIPKGWSV 407
D RL ++ + EVLRL P P++ +RT R + GY IP+G +
Sbjct: 338 KD-----------RARLPLLNATIAEVLRLRPVVPLALPHRTT-RPSSISGYDIPEGTVI 385
Query: 408 MYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQA 467
+ +++ H V+ P E F P+RF ++SR + FG GAR CLG+ LA+
Sbjct: 386 IPNLQGAHLDETVWERPHE-FWPDRFLEPGKNSRA-------LAFGCGARVCLGEPLARL 437
Query: 468 VLQLLAVELVRTARWELATPAFPAMQTVP 496
L ++ L++ + A P++Q +P
Sbjct: 438 ELFVVLTRLLQAFTLLPSGDALPSLQPLP 466
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 83.6 bits (205), Expect = 4e-16
Identities = 117/515 (22%), Positives = 198/515 (38%), Gaps = 65/515 (12%)
Query: 24 LLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTV 83
LLL+++ L L + L +P G PF G L + F ++Y V
Sbjct: 13 LLLAVSLILLYLYGTRTHGLFKKLGIP-GPTPLPFLGNALSFRKGYWTFDMECYKKYRKV 71
Query: 84 FKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRK 143
+ + +P++ ++ + ++T+L+ E V + + + + A E +R R
Sbjct: 72 WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRS 131
Query: 144 VLARVFSRAALERYVPRLQ---GALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGL 200
+L+ F+ L+ VP + L +R G PV++ A + + G+
Sbjct: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191
Query: 201 RLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLHRHLEGA---------- 250
+D +L + VEN L P I+ L LE
Sbjct: 192 SID-----SLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVI 246
Query: 251 ---------ISEKLHEDKAAEPGDALDLIIHSARELGHEP----SMQELKESAVELLFAA 297
I E ++ D L L+I S E S EL ++ +FA
Sbjct: 247 SFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAG 306
Query: 298 FFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPD 357
+ TT+S + ++ L HP K+++E+ ++ PP
Sbjct: 307 YETTSSVLSFIIYELATHPDVQQKVQKEI-------------DTVLPNKAPP-------- 345
Query: 358 LSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHET 417
+ + +L Y+D VV E LRL P R + E++G IPKG VM H
Sbjct: 346 -TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHD 404
Query: 418 AAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELV 477
Y + PE F PERF +D+ + Y PFG G R+C+G A ++L V ++
Sbjct: 405 PK-YWTEPEKFLPERFSKKNKDN---IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVL 460
Query: 478 RTARWELATPAFPAMQT-VPIVHPVDGLRLFFHPL 511
+ ++ P +T +P+ GL L P+
Sbjct: 461 QNFSFK------PCKETQIPLKLRFGGLLLTEKPI 489
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 83.2 bits (204), Expect = 5e-16
Identities = 92/454 (20%), Positives = 182/454 (40%), Gaps = 44/454 (9%)
Query: 57 PFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQ 116
PF G + + F + E+YG VF ++G+ + G++ + ++ + ++
Sbjct: 75 PFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAE 134
Query: 117 --WPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCA 174
+ + + G ++K+L + A +++V ++ + SW
Sbjct: 135 DVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESW-G 193
Query: 175 AGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFS-----LPLDVP 229
G +V++A L A+ L G + +A+ + L + FS LP +P
Sbjct: 194 ESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADL-DGGFSHAAWLLPGWLP 252
Query: 230 FSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEP--GDALDLIIHSARELGHEPSMQELK 287
R+ RD+ HR ++ + + + + ++ D L ++ + + G + E+
Sbjct: 253 LPSFRR----RDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVA 308
Query: 288 ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEG 347
+ LL A T+++ S + L + L + C G
Sbjct: 309 GMLIGLLLAGQHTSSTTSAWMGFFLARDKT-------------LQKKCYLEQKTVCGENL 355
Query: 348 PPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSV 407
PP L+ L L +D +KE LRL PP+ R A + GY IP G V
Sbjct: 356 PP--------LTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQV 407
Query: 408 MYS--IRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELA 465
S + + + V R F+P+R+ +D+ + +F Y+PFG G C+G+ A
Sbjct: 408 CVSPTVNQRLKDSWVERLD---FNPDRY---LQDNPASGEKFAYVPFGAGRHRCIGENFA 461
Query: 466 QAVLQLLAVELVRTARWELATPAFPAMQTVPIVH 499
++ + ++R ++L FP + ++H
Sbjct: 462 YVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIH 495
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 82.0 bits (201), Expect = 1e-15
Identities = 96/406 (23%), Positives = 179/406 (44%), Gaps = 54/406 (13%)
Query: 109 EHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHE 168
+ +LV +P + LG ++LL + H++ + + R ++E V +L
Sbjct: 67 QDKLVSRNYPD---LSLGDYSLLW---KAHKKLTRSALLLGIRDSMEPVVEQLTQEFCER 120
Query: 169 VRSWCAAGGPVSVYDASKALTFRMAARILLGLRL-DEAQCATLARTFEQLVENLFSLPLD 227
+R+ G PV++ + LT + + G ++ D+ + +++++ +
Sbjct: 121 MRA--QPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQ 178
Query: 228 V----------PFSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSAREL 277
+ P GLR+ +A ++ +E + + A + D +D ++ +
Sbjct: 179 IVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQP 238
Query: 278 GHEPSMQELKE-----SAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLG 332
E +L E +AV+LL TTA+ + V+ LL HP +++EEL +
Sbjct: 239 SMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE--- 295
Query: 333 RACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLP--PVSGGYRTA 390
PGA+ S P D RL ++ + EVLRL P P++ +RT
Sbjct: 296 ----LGPGASS-SRVPYKD-----------RARLPLLNATIAEVLRLRPVVPLALPHRTT 339
Query: 391 LRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYI 450
R + GY IP+G ++ +++ H V+ P E F P+RF ++SR +
Sbjct: 340 -RPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHE-FWPDRFLEPGKNSRA-------L 390
Query: 451 PFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVP 496
FG GAR CLG+ LA+ L ++ L++ + A P++Q +P
Sbjct: 391 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLP 436
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 82.0 bits (201), Expect = 1e-15
Identities = 106/458 (23%), Positives = 187/458 (40%), Gaps = 63/458 (13%)
Query: 78 ERYGTVFKTHLLGRPVIRVSGAENVRTILLG-----EHRLVRSQWPQSAHILLGSHTLLG 132
++YG V + ++ + + V+ E+V+ L+ + ++ R+ L G +
Sbjct: 69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 128
Query: 133 AVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGG---PVSVYDA----- 184
E ++R+V+ FSR++L + V A PVS+ D
Sbjct: 129 CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA 188
Query: 185 ----SKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR 240
+KA F M +LLG + +Q L E + + +L +P G RK +R
Sbjct: 189 MDILAKA-AFGMETSMLLGAQKPLSQAVKLM--LEGITASRNTLAKFLP--GKRKQLREV 243
Query: 241 DQLHRHLEGAISEKLHEDKAA------EPGDALDLIIHSARELGHEPSMQELKESAVELL 294
+ R L + + + A P D L I+ + E G + + L ++ V
Sbjct: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA--EEGAQDD-EGLLDNFVTFF 300
Query: 295 FAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGC 354
A T+A+ V+ L + P +A+++ E+ G
Sbjct: 301 IAGHETSANHLAFTVMELSRQPEIVARLQAEV----------------------DEVIGS 338
Query: 355 EPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYS--IR 412
+ L LGRL+Y+ V+KE LRL PP G +R +DG ++P +++S +
Sbjct: 339 KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVM 398
Query: 413 DTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLL 472
+T Y P F+P+RFG RF Y PF G RSC+GQ+ AQ ++++
Sbjct: 399 GRMDT---YFEDPLTFNPDRFGPG-----APKPRFTYFPFSLGHRSCIGQQFAQMEVKVV 450
Query: 473 AVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHP 510
+L++ + L +Q + P+D + P
Sbjct: 451 MAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRP 488
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 79.3 bits (194), Expect = 8e-15
Identities = 98/399 (24%), Positives = 167/399 (41%), Gaps = 48/399 (12%)
Query: 57 PFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGE-HRLVRS 115
PF G L +L F E+YG ++ + +P++ + + ++T+L+ E + + +
Sbjct: 45 PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN 104
Query: 116 QWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGA---LRHEVRSW 172
Q P L S L A E +R R +L+ F+ + VP + L +R
Sbjct: 105 QMPLGPMGFLKS-ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE 163
Query: 173 CAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCAT--LARTFEQLVENLFSLP----- 225
+++ D A T + L G+ LD + ++L++ F P
Sbjct: 164 AENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI 223
Query: 226 -----LDVPFSGLRKGIRARDQLHRHLEGAIS---EKLHEDKAAEPGDALDLIIHS--AR 275
L F L G+ +D H L+ +I E +DK D +I S ++
Sbjct: 224 SLFPFLTPVFEALNIGLFPKDVTH-FLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSK 282
Query: 276 ELGHEPSMQELK--ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGR 333
E ++ +L+ ++ ++FAA+ TT++ ++ L HP K++EE+ A +
Sbjct: 283 ETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK 342
Query: 334 ACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRT 393
A ++ AL ++ Y+D VV E LRL P VS R +
Sbjct: 343 A----------------------PVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKD 380
Query: 394 FELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPER 432
E++G IPKG +VM I H Y + PE F PER
Sbjct: 381 IEINGVFIPKGLAVMVPIYALHHDPK-YWTEPEKFCPER 418
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 76.3 bits (186), Expect = 7e-14
Identities = 138/522 (26%), Positives = 207/522 (39%), Gaps = 90/522 (17%)
Query: 24 LLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRR--ERYG 81
LLL+LA L L LS RA LP G P G L L G+ + R ++YG
Sbjct: 9 LLLALAL-LLLLTLALSGTRARG-HLPPGPTPLPLLGNLLQ-LRPGALYSGLMRLSKKYG 65
Query: 82 TVFKTHL-LGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS---HTLLGAVGEP 137
VF +L RPV+ + G E VR L G+ + + +L G+ H + + GE
Sbjct: 66 PVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRG--TVAMLEGTFDGHGVFFSNGER 123
Query: 138 HRRRRKVLARVFSRAALERY-VPRLQGALRHEVRSWCAA----GGPVSVYDASKAL---T 189
R+ RK F+ AL + + +G + + C G +D S L T
Sbjct: 124 WRQLRK-----FTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQAT 178
Query: 190 FRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSG----------LRKGIRA 239
+ +L GLR + F+ +V L V G LR
Sbjct: 179 SNVVCSLLFGLRFSYED-----KEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGP 233
Query: 240 RDQLHRHLEGAISEKL-----HEDKAAEPGDALDLI-------IHSARELGHEPSMQELK 287
QL H+ + + H+ G A DL+ + G E + + +
Sbjct: 234 HKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNML 293
Query: 288 ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEG 347
+ + LLFA T ++ +LLL+++P +REEL + G +
Sbjct: 294 MTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRE------------LGAGQA 341
Query: 348 PPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGY-RTALRTFELDGYQIPKGWS 406
P SL RL Y D V+ E RLL V G RT +RT GY +P+G
Sbjct: 342 P----------SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTE 391
Query: 407 VMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFH----YIPFGGGARSCLGQ 462
V + +++ P E F+P+RF A RF ++PF G R CLG+
Sbjct: 392 VFPLLGSILHDPNIFKHPEE-FNPDRF-------LDADGRFRKHEAFLPFSLGKRVCLGE 443
Query: 463 ELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGL 504
LA+A L L +++ + L +P P T+ + V GL
Sbjct: 444 GLAKAELFLFFTTILQA--FSLESPCPP--DTLSLKPTVSGL 481
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 75.5 bits (184), Expect = 1e-13
Identities = 87/376 (23%), Positives = 151/376 (40%), Gaps = 66/376 (17%)
Query: 135 GEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSW---CAAGGPVSVYDASKALTFR 191
G+ + R++L F L+ YV + ++R + W P+ V+ +T
Sbjct: 136 GQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLD 195
Query: 192 MAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQL-------- 243
+ + Q ++++ Q + +L +L FS +R D +
Sbjct: 196 TIMKCAFSHQ-GSIQVDRNSQSYIQAISDLNNLV----FSRVRNAFHQNDTIYSLTSAGR 250
Query: 244 ---------HRHLEGAISEK---------LHEDKAAEPGDALDLIIHSARELGHEPSMQE 285
H+H + I + L + K D LD+++ + E G S ++
Sbjct: 251 WTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKD 310
Query: 286 LKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGS 345
L+ +F TTAS + ++ L HP + REE+ +
Sbjct: 311 LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSL---------------- 354
Query: 346 EGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSG-GYRTALRTFELDGYQIPKG 404
G ++ L ++ Y +KE LRL PPV G G + DG +PKG
Sbjct: 355 ------LGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG 408
Query: 405 WSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFH-YIPFGGGARSCLGQE 463
V+ SI H V+ +P E FDP RF G++ H ++PF GG+R+C+G++
Sbjct: 409 IMVLLSIYGLHHNPKVWPNP-EVFDPFRFAP------GSAQHSHAFLPFSGGSRNCIGKQ 461
Query: 464 LAQAVLQL-LAVELVR 478
A L++ A+ L+R
Sbjct: 462 FAMNELKVATALTLLR 477
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 74.7 bits (182), Expect = 2e-13
Identities = 91/377 (24%), Positives = 151/377 (40%), Gaps = 59/377 (15%)
Query: 135 GEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSW---CAAGGPVSVYDASKALTFR 191
G+ + R++L F L+ YV + ++R + W P+ V+ +T
Sbjct: 136 GQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLD 195
Query: 192 MAARILLGLRLDEAQCATLARTFEQLVENLFSLPL----------DVPFSGLRKGI---R 238
+ + Q ++++ Q + +L SL D +S G R
Sbjct: 196 TIMKSAFSHQ-GSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHR 254
Query: 239 ARDQLHRHLEGAISEK---------LHEDKAAEPGDALDLIIHSARELGHEPSMQELKES 289
A H+H + I + L + K D LD+++ + E G S ++L+
Sbjct: 255 ACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAE 314
Query: 290 AVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPP 349
+F TTAS + ++ L HP + REE+ GL
Sbjct: 315 VDTFMFEGHDTTASGISWILYALATHPKHQERCREEI--HGL------------------ 354
Query: 350 PDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSG-GYRTALRTFELDGYQIPKGWSVM 408
G ++ L ++ Y +KE LRL PPV G G + DG +PKG V+
Sbjct: 355 --LGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVL 412
Query: 409 YSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFH-YIPFGGGARSCLGQELAQA 467
SI H V+ + E FDP RF G++ H ++PF GG+R+C+G++ A
Sbjct: 413 LSIYGLHHNPKVWPNL-EVFDPSRFAP------GSAQHSHAFLPFSGGSRNCIGKQF--A 463
Query: 468 VLQLLAVELVRTARWEL 484
+ QL + R+EL
Sbjct: 464 MNQLKVARALTLLRFEL 480
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 74.3 bits (181), Expect = 2e-13
Identities = 80/368 (21%), Positives = 151/368 (41%), Gaps = 42/368 (11%)
Query: 141 RRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGL 200
++K+L + A +++V ++ + SW G +V++A L A+ L G
Sbjct: 56 QKKMLKSGLNIAHFKQHVSIIEKETKEYFESW-GESGEKNVFEALSELIILTASHCLHGK 114
Query: 201 RLDEAQCATLARTFEQLVENLFS-----LPLDVPFSGLRKGIRARDQLHRHLEGAISEKL 255
+ +A+ + L + FS LP +P R+ RD+ HR ++ + +
Sbjct: 115 EIRSQLNEKVAQLYADL-DGGFSHAAWLLPGWLPLPSFRR----RDRAHREIKDIFYKAI 169
Query: 256 HEDKAAEP--GDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLL 313
+ + ++ D L ++ + + G + E+ + LL A T+++ S + L
Sbjct: 170 QKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLA 229
Query: 314 QHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVV 373
+ L + C G PP L+ L L +D +
Sbjct: 230 RDKT-------------LQKKCYLEQKTVCGENLPP--------LTYDQLKDLNLLDRCI 268
Query: 374 KEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYS--IRDTHETAAVYRSPPEGFDPE 431
KE LRL PP+ R A + GY IP G V S + + + V R F+P+
Sbjct: 269 KETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD---FNPD 325
Query: 432 RFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPA 491
R+ +D+ + +F Y+PFG G C+G+ A ++ + ++R ++L FP
Sbjct: 326 RY---LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPT 382
Query: 492 MQTVPIVH 499
+ ++H
Sbjct: 383 VNYTTMIH 390
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 73.2 bits (178), Expect = 6e-13
Identities = 113/414 (27%), Positives = 164/414 (39%), Gaps = 63/414 (15%)
Query: 115 SQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRA-ALERYVPRLQGALRHEVRSWC 173
S W + + LL A GE +R R +LA + R A RY L + VR
Sbjct: 111 SPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLR 170
Query: 174 -----AAGGPVSVYD-ASKALTFRMA--ARILLGLRLD--EAQCATLARTFEQLVENLFS 223
G P V D A + F + A +LLG RL EAQ TF + V ++F
Sbjct: 171 RQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFV 230
Query: 224 ---LPLDVPFSGLRKGI--------RARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIH 272
L + +P LR + R DQ+ + + E+ + A G + +
Sbjct: 231 STLLTMAMPH-WLRHLVPGPWGRLCRDWDQMFAFAQRHV-ERREAEAAMRNGGQPEKDLE 288
Query: 273 SARELGHEPSMQELKESAV-----ELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELV 327
S L H +EL ++ ELL A T ++ + + L +HP + E+
Sbjct: 289 SGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEIT 348
Query: 328 AQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGY 387
A + GS P S L +L + VVKEVLRL P V G
Sbjct: 349 A-----------ALSPGSSAYP---------SATVLSQLPLLKAVVKEVLRLYPVVPGNS 388
Query: 388 RTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSR- 446
R + + Y IPK V T A R P + +P F AR G +
Sbjct: 389 RVPDKDIHVGDYIIPKNTLV------TLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHP 442
Query: 447 FHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWEL-----ATPAFPAMQTV 495
F +PFG G RSC+G+ LA+ LQ+ +++ +E+ A P P +TV
Sbjct: 443 FASLPFGFGKRSCMGRRLAELELQMALAQIL--THFEVQPEPGAAPVRPKTRTV 494
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 73.2 bits (178), Expect = 6e-13
Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 28/217 (12%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D +D+++ S E G + S ++++ A +F TTAS + ++ L +HP + R+
Sbjct: 297 DFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQ 356
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEP-DLSLAALGRLRYVDCVVKEVLRLLPPV 383
E+ R EP ++ L +L ++ +KE LRL PPV
Sbjct: 357 EVQELLKDR---------------------EPKEIEWDDLAQLPFLTMCIKESLRLHPPV 395
Query: 384 SGGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRG 442
R + L DG IPKG + S+ TH AV+ P E +DP RF R
Sbjct: 396 PAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDP-EVYDPFRFDPKNIKER- 453
Query: 443 ASSRFHYIPFGGGARSCLGQELAQAVLQ-LLAVELVR 478
S +IPF G R+C+GQ A A ++ +L + L+R
Sbjct: 454 --SPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLR 488
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 72.8 bits (177), Expect = 7e-13
Identities = 129/508 (25%), Positives = 205/508 (40%), Gaps = 90/508 (17%)
Query: 20 LCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSR-RE 78
L GLLL L Q R + DR LP G P G L +G R RE
Sbjct: 11 LLTGLLLLLVQ-----RHPNTHDR-----LPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
Query: 79 RYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS-AHILLGSHTLLGAVGEP 137
+YG VF HL RPV+ + G E +R L+ + + + + ++ A G
Sbjct: 61 KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGN- 119
Query: 138 HRRRRKVLAR----------VFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA 187
R KVL R + R+ ER Q + +S A P ++ ++
Sbjct: 120 ---RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLF---QS 173
Query: 188 LTFRMAARILLGLRL--DEAQCATLARTFEQ---LVENLFSLPLDVPFSGLRKGIR-ARD 241
+T + I+ G R + + + F Q L+ ++F ++ FSG K A
Sbjct: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL-FSGFLKYFPGAHR 232
Query: 242 QLHRHLE------GAISEKLHED-KAAEPGDALDL-IIHSARELGH---EPSMQELKESA 290
Q++++L+ G EK E + P D +D ++H +E + E S Q L +
Sbjct: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292
Query: 291 VELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPP 350
+ L FA TT++ LL+L++P ++ E+ G PP
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQ-------------VIGPHRPP- 338
Query: 351 DCGCEPDLSLAALGRLRYVDCVVKEVLR---LLPPVSGGYRTALRTFELDGYQIPKGWSV 407
L ++ Y + V+ E+ R LLP T +F GY IPK V
Sbjct: 339 --------ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR--GYIIPKDTEV 388
Query: 408 MY----SIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFH-YIPFGGGARSCLGQ 462
++ D H Y P+ F+P+ F D+ GA + +IPF G R CLG+
Sbjct: 389 FLILSTALHDPH-----YFEKPDAFNPDHF----LDANGALKKTEAFIPFSLGKRICLGE 439
Query: 463 ELAQAVLQLLAVELVRTARWELATPAFP 490
+A+A L L +++ + +A+P P
Sbjct: 440 GIARAELFLFFTTILQ--NFSMASPVAP 465
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 72.8 bits (177), Expect = 7e-13
Identities = 72/293 (24%), Positives = 121/293 (41%), Gaps = 42/293 (14%)
Query: 234 RKGIRARDQLHRHLEGAISEK---LHEDKAAEPG------DALDLIIHSARELGHEPSMQ 284
R+ +RA H H + I E+ L ++K + D LD+++ + E + S
Sbjct: 245 RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDA 304
Query: 285 ELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGG 344
+L+ +F TT S + + + +P + REE V + LG
Sbjct: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREE-VREILGD----------- 352
Query: 345 SEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALR--TFELDGYQIP 402
+ LG++ Y+ +KE RL PPV YR + TF +DG +P
Sbjct: 353 ----------QDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-VDGRSLP 401
Query: 403 KGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSR--FHYIPFGGGARSCL 460
G + I H +AV+ DPE F + R + AS R F ++PF G R+C+
Sbjct: 402 AGSLISMHIYALHRNSAVWP------DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 455
Query: 461 GQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTP 513
GQ+ A + ++++ + + L P ++ +G L PL P
Sbjct: 456 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 508
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 72.8 bits (177), Expect = 7e-13
Identities = 72/293 (24%), Positives = 121/293 (41%), Gaps = 42/293 (14%)
Query: 234 RKGIRARDQLHRHLEGAISEK---LHEDKAAEPG------DALDLIIHSARELGHEPSMQ 284
R+ +RA H H + I E+ L ++K + D LD+++ + E + S
Sbjct: 244 RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDA 303
Query: 285 ELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGG 344
+L+ +F TT S + + + +P + REE V + LG
Sbjct: 304 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREE-VREILGD----------- 351
Query: 345 SEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALR--TFELDGYQIP 402
+ LG++ Y+ +KE RL PPV YR + TF +DG +P
Sbjct: 352 ----------QDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF-VDGRSLP 400
Query: 403 KGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSR--FHYIPFGGGARSCL 460
G + I H +AV+ DPE F + R + AS R F ++PF G R+C+
Sbjct: 401 AGSLISMHIYALHRNSAVWP------DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCI 454
Query: 461 GQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTP 513
GQ+ A + ++++ + + L P ++ +G L PL P
Sbjct: 455 GQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 507
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 72.8 bits (177), Expect = 7e-13
Identities = 69/252 (27%), Positives = 108/252 (42%), Gaps = 29/252 (11%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D +D+++ + E G E S ++++ A +F TT+S + ++ L ++P K RE
Sbjct: 304 DFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCRE 363
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVS 384
E+ GR +L L +L + +KE LR PPV+
Sbjct: 364 EIQEVMKGREL--------------------EELEWDDLTQLPFTTMCIKESLRQYPPVT 403
Query: 385 GGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGA 443
R +L DG IPKG + SI TH V+ + ++P RF R
Sbjct: 404 LVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVW-PDSKVYNPYRFDPDNPQQR-- 460
Query: 444 SSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVP--IVHPV 501
S Y+PF G R+C+GQ A A +L V + R+ L+ ++ P I+
Sbjct: 461 -SPLAYVPFSAGPRNCIGQSFAMA--ELRVVVALTLLRFRLSVDRTRKVRRKPELILRTE 517
Query: 502 DGLRLFFHPLTP 513
+GL L PL P
Sbjct: 518 NGLWLKVEPLPP 529
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 71.6 bits (174), Expect = 2e-12
Identities = 65/217 (29%), Positives = 100/217 (46%), Gaps = 28/217 (12%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D +D+++ S E G + S ++++ A +F TTAS + ++ L +HP + R+
Sbjct: 297 DFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQ 356
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEP-DLSLAALGRLRYVDCVVKEVLRLLPPV 383
E+ R EP ++ L L ++ +KE LRL PPV
Sbjct: 357 EVQELLKDR---------------------EPKEIEWDDLAHLPFLTMCMKESLRLHPPV 395
Query: 384 SGGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRG 442
R + L DG IPKG + S+ TH AV+ P E +DP RF R
Sbjct: 396 PVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDP-EVYDPFRFDPENIKER- 453
Query: 443 ASSRFHYIPFGGGARSCLGQELAQAVLQ-LLAVELVR 478
S +IPF G R+C+GQ A A ++ +LA+ L+R
Sbjct: 454 --SPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLR 488
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 71.2 bits (173), Expect = 2e-12
Identities = 66/252 (26%), Positives = 108/252 (42%), Gaps = 33/252 (13%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D LD+++ + E G S ++ L A T A++ + ++ L +P + RE
Sbjct: 285 DFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCRE 344
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVS 384
E+ +G+ G ++ LG + Y +KE RL+P V
Sbjct: 345 EV--RGI--------------------LGDGSSITWDQLGEMSYTTMCIKETCRLIPAVP 382
Query: 385 GGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGA 443
R + DG +P G +V+ SI H AV+++P + FDP RF D R
Sbjct: 383 SISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNP-KVFDPLRFSQENSDQRHP 441
Query: 444 SSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVP---IVHP 500
+ Y+PF G+R+C+GQE A L++ ++ R TP T P I+ P
Sbjct: 442 ---YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFR---VTPDPTRPLTFPNHFILKP 495
Query: 501 VDGLRLFFHPLT 512
+G+ L L+
Sbjct: 496 KNGMYLHLKKLS 507
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 70.5 bits (171), Expect = 4e-12
Identities = 73/250 (29%), Positives = 110/250 (44%), Gaps = 30/250 (12%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D +D+++ S E G E S ++++ A +F TTAS + ++ L +HP + R+
Sbjct: 297 DFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQ 356
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEP-DLSLAALGRLRYVDCVVKEVLRLLPPV 383
E+ R EP ++ L +L ++ +KE LRL PPV
Sbjct: 357 EVQELLKDR---------------------EPIEIEWDDLAQLPFLTMCIKESLRLHPPV 395
Query: 384 SGGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRG 442
R + F L DG IPKG + +I H V+ P E +DP RF R
Sbjct: 396 PVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDP-EVYDPFRFDQENIKER- 453
Query: 443 ASSRFHYIPFGGGARSCLGQELAQAVLQ-LLAVELVRTARWELATPAFPAMQTVPIVHPV 501
S +IPF G R+C+GQ A A ++ +LA+ L+ L T P + I+
Sbjct: 454 --SPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFR--ILPTHTEPRRKPELILRAE 509
Query: 502 DGLRLFFHPL 511
GL L PL
Sbjct: 510 GGLWLRVEPL 519
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 70.5 bits (171), Expect = 4e-12
Identities = 73/250 (29%), Positives = 110/250 (44%), Gaps = 30/250 (12%)
Query: 265 DALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIRE 324
D +D+++ S E G E S ++++ A +F TTAS + ++ L +HP + R+
Sbjct: 297 DFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQ 356
Query: 325 ELVAQGLGRACGCAPGAAGGSEGPPPDCGCEP-DLSLAALGRLRYVDCVVKEVLRLLPPV 383
E+ R EP ++ L +L ++ +KE LRL PPV
Sbjct: 357 EVQELLKDR---------------------EPIEIEWDDLAQLPFLTMCIKESLRLHPPV 395
Query: 384 SGGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRG 442
R + F L DG IPKG + +I H V+ P E +DP RF R
Sbjct: 396 PVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDP-EVYDPFRFDQENIKER- 453
Query: 443 ASSRFHYIPFGGGARSCLGQELAQAVLQ-LLAVELVRTARWELATPAFPAMQTVPIVHPV 501
S +IPF G R+C+GQ A A ++ +LA+ L+ L T P + I+
Sbjct: 454 --SPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFR--ILPTHTEPRRKPELILRAE 509
Query: 502 DGLRLFFHPL 511
GL L PL
Sbjct: 510 GGLWLRVEPL 519
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 69.3 bits (168), Expect = 8e-12
Identities = 71/257 (27%), Positives = 114/257 (44%), Gaps = 27/257 (10%)
Query: 257 EDKA-AEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQH 315
+DKA ++ D +D+++ S E G S ++++ A +F TTAS + ++ L +H
Sbjct: 288 KDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARH 347
Query: 316 PAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKE 375
P + R+E+ R ++ L +L ++ VKE
Sbjct: 348 PEYQERCRQEVQELLKDRD--------------------PKEIEWDDLAQLPFLTMCVKE 387
Query: 376 VLRLLPPVSGGYRTALRTFEL-DGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFG 434
LRL PP R + L DG IPKG + + I H V+ P E +DP RF
Sbjct: 388 SLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDP-EVYDPFRFD 446
Query: 435 AAREDSRGASSRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQT 494
E+S+G S +IPF G R+C+GQ A A ++++ ++ R+ L P +
Sbjct: 447 P--ENSKGRSP-LAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF-LPDHTEPRRKL 502
Query: 495 VPIVHPVDGLRLFFHPL 511
I+ GL L PL
Sbjct: 503 ELIMRAEGGLWLRVEPL 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,631,684
Number of Sequences: 37866
Number of extensions: 927379
Number of successful extensions: 2951
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2763
Number of HSP's gapped (non-prelim): 113
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.