Search of human proteins with 61806622

Search of human proteins with 61806622

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61806622 epithelial mitogen [Homo sapiens]
         (133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61806622 epithelial mitogen [Homo sapiens]                         276   5e-75
gi|29568105 transmembrane protein with EGF-like and two follista...    56   7e-09
gi|4557567 epiregulin preproprotein [Homo sapiens]                     55   2e-08
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s...    54   3e-08
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                       54   3e-08
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap...    53   6e-08
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                       51   2e-07
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]                50   5e-07
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]            50   5e-07
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]             50   5e-07
gi|20070380 neuregulin 4 [Homo sapiens]                                47   3e-06
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]            47   4e-06
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]             47   4e-06
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]       46   8e-06
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                       46   8e-06
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]            46   1e-05
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]            46   1e-05
gi|12383051 transmembrane protein with EGF-like and two follista...    46   1e-05
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                       46   1e-05
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]               44   3e-05
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]                   44   3e-05
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]                43   6e-05
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...    43   8e-05
gi|4502199 amphiregulin preproprotein [Homo sapiens]                   41   3e-04
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]                  41   3e-04
gi|4502461 betacellulin [Homo sapiens]                                 39   0.001
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]             38   0.003
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]            37   0.006
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]                    37   0.006
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]                  37   0.006

>gi|61806622 epithelial mitogen [Homo sapiens]
          Length = 133

 Score =  276 bits (705), Expect = 5e-75
 Identities = 133/133 (100%), Positives = 133/133 (100%)

Query: 1   MALGVPISVYLLFNAMTALTEEAAVTVTPPITAQQADNIEGPIALKFSHLCLEDHNSYCI 60
           MALGVPISVYLLFNAMTALTEEAAVTVTPPITAQQADNIEGPIALKFSHLCLEDHNSYCI
Sbjct: 1   MALGVPISVYLLFNAMTALTEEAAVTVTPPITAQQADNIEGPIALKFSHLCLEDHNSYCI 60

Query: 61  NGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVGLLLSGFLVIF 120
           NGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVGLLLSGFLVIF
Sbjct: 61  NGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVGLLLSGFLVIF 120

Query: 121 YCYIRKRYEKDKI 133
           YCYIRKRYEKDKI
Sbjct: 121 YCYIRKRYEKDKI 133


>gi|29568105 transmembrane protein with EGF-like and two
           follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 56.2 bits (134), Expect = 7e-09
 Identities = 31/80 (38%), Positives = 44/80 (55%), Gaps = 4/80 (5%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLT-SYAVDSYEK--YIAIGI 107
           C E+ N YCI+G C F +  +KA CRC +GYTG+ CE    +  Y V S +K  ++ I  
Sbjct: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAA 334

Query: 108 GVGLLLSGFLV-IFYCYIRK 126
            +G +    +V I  C  RK
Sbjct: 335 IIGAVQIAIIVAIVMCITRK 354


>gi|4557567 epiregulin preproprotein [Homo sapiens]
          Length = 169

 Score = 55.1 bits (131), Expect = 2e-08
 Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 11/88 (12%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVG 110
           C  D N YC++G C +  ++ +  CRC  GYTG RCEH  LT +   S E Y+A+ +   
Sbjct: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKE-YVALTV--- 123

Query: 111 LLLSGFLV------IFYC-YIRKRYEKD 131
           +L+  FL+       ++C + R R  K+
Sbjct: 124 ILIILFLITVVGSTYYFCRWYRNRKSKE 151


>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
           sapiens]
          Length = 159

 Score = 54.3 bits (129), Expect = 3e-08
 Identities = 31/125 (24%), Positives = 52/125 (41%), Gaps = 15/125 (12%)

Query: 11  LLFNAMTALTEEAAVTVTPPITAQQADNIEGPIALKFSHLCLEDHNSYCINGACAFHHEL 70
           ++  A  AL    +    PP+ A    +            C + H  +C +G C F  + 
Sbjct: 15  IVLAACQALENSTSPLSDPPVAAAVVSHFND---------CPDSHTQFCFHGTCRFLVQE 65

Query: 71  EKAICRCFTGYTGERCEHLTLTSYAVDSYEK------YIAIGIGVGLLLSGFLVIFYCYI 124
           +K  C C +GY G RCEH  L +    S +K       +   + + +L+   ++I  C +
Sbjct: 66  DKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQV 125

Query: 125 RKRYE 129
           RK  E
Sbjct: 126 RKHCE 130


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score = 54.3 bits (129), Expect = 3e-08
 Identities = 29/83 (34%), Positives = 48/83 (57%), Gaps = 6/83 (7%)

Query: 51  CLEDHNSYCINGACAFHHE-LEKAICRCFTGYTGERCEHLTLTSY--AVDSYEKYI--AI 105
           C E   SYC+NG   ++ E + +  C+C  GYTG+RC+   + ++  A + Y+K +    
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTIT 404

Query: 106 GIGVGLLLSGFL-VIFYCYIRKR 127
           GI V LL+ G + V+ YC  +K+
Sbjct: 405 GICVALLVVGIVCVVAYCKTKKQ 427


>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
           sapiens]
          Length = 160

 Score = 53.1 bits (126), Expect = 6e-08
 Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 6/85 (7%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEK------YIA 104
           C + H  +C +G C F  + +K  C C +GY G RCEH  L +    S +K       + 
Sbjct: 47  CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVV 106

Query: 105 IGIGVGLLLSGFLVIFYCYIRKRYE 129
             + + +L+   ++I  C +RK  E
Sbjct: 107 SIVALAVLIITCVLIHCCQVRKHCE 131


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score = 51.2 bits (121), Expect = 2e-07
 Identities = 29/91 (31%), Positives = 48/91 (52%), Gaps = 14/91 (15%)

Query: 51  CLEDHNSYCINGACAFHHE-LEKAICRCFTGYTGERCEHLTLTSY----------AVDSY 99
           C E   SYC+NG   ++ E + +  C+C  GYTG+RC+   + ++          A + Y
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELY 404

Query: 100 EKYI--AIGIGVGLLLSGFL-VIFYCYIRKR 127
           +K +    GI V LL+ G + V+ YC  +K+
Sbjct: 405 QKRVLTITGICVALLVVGIVCVVAYCKTKKQ 435


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score = 50.1 bits (118), Expect = 5e-07
 Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 17/136 (12%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY--AVDSYEKYI--AIGIGVGLLLSG 115
            C    +L    + +C+C   +TG+RC++  + S+  A + Y+K +    GI + LL+ G
Sbjct: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVG 254

Query: 116 FL-VIFYCYIRKRYEK 130
            + V+ YC  +K+ +K
Sbjct: 255 IMCVVAYCKTKKQRKK 270


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score = 50.1 bits (118), Expect = 5e-07
 Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 17/136 (12%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY--AVDSYEKYI--AIGIGVGLLLSG 115
            C    +L    + +C+C   +TG+RC++  + S+  A + Y+K +    GI + LL+ G
Sbjct: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVG 254

Query: 116 FL-VIFYCYIRKRYEK 130
            + V+ YC  +K+ +K
Sbjct: 255 IMCVVAYCKTKKQRKK 270


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score = 50.1 bits (118), Expect = 5e-07
 Identities = 39/136 (28%), Positives = 67/136 (49%), Gaps = 17/136 (12%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY--AVDSYEKYI--AIGIGVGLLLSG 115
            C    +L    + +C+C   +TG+RC++  + S+  A + Y+K +    GI + LL+ G
Sbjct: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVG 254

Query: 116 FL-VIFYCYIRKRYEK 130
            + V+ YC  +K+ +K
Sbjct: 255 IMCVVAYCKTKKQRKK 270


>gi|20070380 neuregulin 4 [Homo sapiens]
          Length = 115

 Score = 47.4 bits (111), Expect = 3e-06
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 5/71 (7%)

Query: 51  CLEDHNSYCINGA-CAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDS----YEKYIAI 105
           C   H S+C+NG  C     +    CRC   YTG RCE + L   ++ +    +E ++A+
Sbjct: 9   CGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVAL 68

Query: 106 GIGVGLLLSGF 116
            + V L++  F
Sbjct: 69  AVLVTLIIGAF 79


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score = 47.0 bits (110), Expect = 4e-06
 Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 25/144 (17%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 114 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 173

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY----------AVDSYEKYI--AIGI 107
            C    +L    + +C+C   +TG+RC++  + S+          A + Y+K +    GI
Sbjct: 174 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGI 233

Query: 108 GVGLLLSGFL-VIFYCYIRKRYEK 130
            + LL+ G + V+ YC  +K+ +K
Sbjct: 234 CIALLVVGIMCVVAYCKTKKQRKK 257


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score = 47.0 bits (110), Expect = 4e-06
 Identities = 39/144 (27%), Positives = 67/144 (46%), Gaps = 25/144 (17%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY----------AVDSYEKYI--AIGI 107
            C    +L    + +C+C   +TG+RC++  + S+          A + Y+K +    GI
Sbjct: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGI 254

Query: 108 GVGLLLSGFL-VIFYCYIRKRYEK 130
            + LL+ G + V+ YC  +K+ +K
Sbjct: 255 CIALLVVGIMCVVAYCKTKKQRKK 278


>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
          Length = 208

 Score = 46.2 bits (108), Expect = 8e-06
 Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 1/81 (1%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTL-TSYAVDSYEKYIAIGIGV 109
           CL  +  +CI+G C +  EL    C C  GY GERC  L+L     + +Y+    + +  
Sbjct: 108 CLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVA 167

Query: 110 GLLLSGFLVIFYCYIRKRYEK 130
            +L S  L++    +  RY +
Sbjct: 168 VVLSSVCLLVIVGLLMFRYHR 188


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score = 46.2 bits (108), Expect = 8e-06
 Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 12/89 (13%)

Query: 51  CLEDHNSYCINGACAFHHE-LEKAICRCFTGYTGERC-EHLTLTSY-------AVDSYEK 101
           C E   SYC+NG   ++ E + +  C+C  G+ G+RC E L L  Y       A + Y+K
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQK 404

Query: 102 YI--AIGIGVGLLLSGFL-VIFYCYIRKR 127
            +    GI V LL+ G + V+ YC  +K+
Sbjct: 405 RVLTITGICVALLVVGIVCVVAYCKTKKQ 433


>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score = 45.8 bits (107), Expect = 1e-05
 Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 19/102 (18%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERCEHLTLTSY------- 94
           SHL  C E   ++C+NG  C    +L    + +C+C   +TG+RC++  + S+       
Sbjct: 122 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE 181

Query: 95  ---AVDSYEKYI--AIGIGVGLLLSGFL-VIFYCYIRKRYEK 130
              A + Y+K +    GI + LL+ G + V+ YC  +K+ +K
Sbjct: 182 FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 223


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score = 45.8 bits (107), Expect = 1e-05
 Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 19/102 (18%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERCEHLTLTSY------- 94
           SHL  C E   ++C+NG  C    +L    + +C+C   +TG+RC++  + S+       
Sbjct: 139 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE 198

Query: 95  ---AVDSYEKYI--AIGIGVGLLLSGFL-VIFYCYIRKRYEK 130
              A + Y+K +    GI + LL+ G + V+ YC  +K+ +K
Sbjct: 199 FMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 240


>gi|12383051 transmembrane protein with EGF-like and two
           follistatin-like domains 2 [Homo sapiens]
          Length = 374

 Score = 45.8 bits (107), Expect = 1e-05
 Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 4/87 (4%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLT-SYAVDSYEK--YIAIGI 107
           C E +N +C++G C     +++  CRC  GYTG+ CE    +  Y V    +  Y+ I  
Sbjct: 265 CPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAA 324

Query: 108 GVGLL-LSGFLVIFYCYIRKRYEKDKI 133
            +G + ++   V+  C  RK    ++I
Sbjct: 325 VIGTIQIAVICVVVLCITRKCPRSNRI 351


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score = 45.8 bits (107), Expect = 1e-05
 Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 20/97 (20%)

Query: 51  CLEDHNSYCINGACAFHHE-LEKAICRCFTGYTGERC-EHLTLTSYAVDSYEKYIAI--- 105
           C E   SYC+NG   ++ E + +  C+C  G+ G+RC E L L  Y  D  +K++     
Sbjct: 345 CNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELK 404

Query: 106 --------------GIGVGLLLSGFL-VIFYCYIRKR 127
                         GI V LL+ G + V+ YC  +K+
Sbjct: 405 EAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQ 441


>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
          Length = 640

 Score = 44.3 bits (103), Expect = 3e-05
 Identities = 40/139 (28%), Positives = 66/139 (47%), Gaps = 20/139 (14%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERC-EHLTL----TSYAVDSYEKYI--AIGIGVGLL 112
            C    +L    + +C+C  G+TG RC E++ +       A + Y+K +    GI + LL
Sbjct: 195 ECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALL 254

Query: 113 LSGFL-VIFYCYIRKRYEK 130
           + G + V+ YC  +K+ +K
Sbjct: 255 VVGIMCVVAYCKTKKQRKK 273


>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
          Length = 462

 Score = 44.3 bits (103), Expect = 3e-05
 Identities = 40/139 (28%), Positives = 66/139 (47%), Gaps = 20/139 (14%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERC-EHLTL----TSYAVDSYEKYI--AIGIGVGLL 112
            C    +L    + +C+C  G+TG RC E++ +       A + Y+K +    GI + LL
Sbjct: 195 ECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALL 254

Query: 113 LSGFL-VIFYCYIRKRYEK 130
           + G + V+ YC  +K+ +K
Sbjct: 255 VVGIMCVVAYCKTKKQRKK 273


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score = 43.1 bits (100), Expect = 6e-05
 Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 14/97 (14%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERC-EHLTL----TSYAV 96
           SHL  C E   ++C+NG  C    +L    + +C+C  G+TG RC E++ +       A 
Sbjct: 23  SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE 82

Query: 97  DSYEKYI--AIGIGVGLLLSGFL-VIFYCYIRKRYEK 130
           + Y+K +    GI + LL+ G + V+ YC  +K+ +K
Sbjct: 83  ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 119


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
            sapiens]
          Length = 1207

 Score = 42.7 bits (99), Expect = 8e-05
 Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 1/42 (2%)

Query: 51   CLEDHNSYCIN-GACAFHHELEKAICRCFTGYTGERCEHLTL 91
            C   H+ YC++ G C +   L+K  C C  GY GERC++  L
Sbjct: 976  CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDL 1017


>gi|4502199 amphiregulin preproprotein [Homo sapiens]
          Length = 252

 Score = 40.8 bits (94), Expect = 3e-04
 Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYA-VDSYEKYIAI 105
           C  +  ++CI+G C +   LE   C+C   Y GERC   ++ +++ +DS    IA+
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201


>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
          Length = 252

 Score = 40.8 bits (94), Expect = 3e-04
 Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 1/56 (1%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYA-VDSYEKYIAI 105
           C  +  ++CI+G C +   LE   C+C   Y GERC   ++ +++ +DS    IA+
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIAL 201


>gi|4502461 betacellulin [Homo sapiens]
          Length = 178

 Score = 39.3 bits (90), Expect = 0.001
 Identities = 27/86 (31%), Positives = 39/86 (45%), Gaps = 5/86 (5%)

Query: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVG 110
           C + +  YCI G C F    +   C C  GY G RCE + L     D  +  +   I V 
Sbjct: 69  CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQILVICLIAV- 127

Query: 111 LLLSGFLVIFYCY----IRKRYEKDK 132
           +++   LVI  C     +RKR ++ K
Sbjct: 128 MVVFIILVIGVCTCCHPLRKRRKRKK 153


>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
          Length = 241

 Score = 37.7 bits (86), Expect = 0.003
 Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 12/95 (12%)

Query: 12  LFNAMTALTEEAAVTVTPPI---TAQQADNIEGPIALKF---SHL--CLEDHNSYCINGA 63
           +   M A TE A V+   PI    + +  N     +      SHL  C E   ++C+NG 
Sbjct: 135 IITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194

Query: 64  -CAFHHELE---KAICRCFTGYTGERCEHLTLTSY 94
            C    +L    + +C+C   +TG+RC++  + S+
Sbjct: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 229


>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
          Length = 207

 Score = 36.6 bits (83), Expect = 0.006
 Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 6/53 (11%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERCEHLTLTSY 94
           SHL  C E   ++C+NG  C    +L    + +C+C   +TG+RC++  + S+
Sbjct: 143 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 195


>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
          Length = 296

 Score = 36.6 bits (83), Expect = 0.006
 Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 6/53 (11%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERCEHLTLTSY 94
           SHL  C E   ++C+NG  C    +L    + +C+C   +TG+RC++  + S+
Sbjct: 232 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 284


>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
          Length = 422

 Score = 36.6 bits (83), Expect = 0.006
 Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 6/53 (11%)

Query: 48  SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERCEHLTLTSY 94
           SHL  C E   ++C+NG  C    +L    + +C+C   +TG+RC++  + S+
Sbjct: 358 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF 410


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.140    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,919,915
Number of Sequences: 37866
Number of extensions: 195788
Number of successful extensions: 1324
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 848
Number of HSP's gapped (non-prelim): 502
length of query: 133
length of database: 18,247,518
effective HSP length: 91
effective length of query: 42
effective length of database: 14,801,712
effective search space: 621671904
effective search space used: 621671904
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.