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Search of human proteins with 13540531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13540531 integrin-linked kinase-associated protein
phosphatase 2C [Homo sapiens]
(392 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13540531 integrin-linked kinase-associated protein phosphatas... 781 0.0
gi|7661862 protein phosphatase 1F [Homo sapiens] 125 7e-29
gi|30089948 protein phosphatase 1E [Homo sapiens] 122 7e-28
gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens] 120 2e-27
gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens] 120 2e-27
gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens] 120 2e-27
gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens] 115 5e-26
gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens] 113 3e-25
gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens] 113 3e-25
gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens] 113 3e-25
gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens] 113 3e-25
gi|167466276 protein phosphatase 1K (PP2C domain containing) [Ho... 112 8e-25
gi|122937199 protein phosphatase 1B-like [Homo sapiens] 105 5e-23
gi|4505999 protein phosphatase 1G [Homo sapiens] 89 7e-18
gi|29826282 protein phosphatase 1G [Homo sapiens] 89 7e-18
gi|4505997 protein phosphatase 1D [Homo sapiens] 70 3e-12
gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit ... 63 4e-10
gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit... 63 4e-10
gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit... 63 4e-10
gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit... 63 4e-10
gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit... 63 4e-10
gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo... 57 4e-08
gi|5174703 mitogen-activated protein kinase kinase kinase 7 inte... 52 1e-06
gi|41281798 mitogen-activated protein kinase kinase kinase 7 int... 52 1e-06
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 51 2e-06
gi|149944715 protein phosphatase 1H (PP2C domain containing) [Ho... 46 7e-05
gi|171460932 protein phosphatase 1M isoform a [Homo sapiens] 45 1e-04
gi|171460934 protein phosphatase 1M isoform b [Homo sapiens] 44 3e-04
gi|65506328 protein phosphatase 1J (PP2C domain containing) [Hom... 41 0.002
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 40 0.004
>gi|13540531 integrin-linked kinase-associated protein phosphatase
2C [Homo sapiens]
Length = 392
Score = 781 bits (2018), Expect = 0.0
Identities = 392/392 (100%), Positives = 392/392 (100%)
Query: 1 MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG 60
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG
Sbjct: 1 MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSG 60
Query: 61 SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE 120
SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE
Sbjct: 61 SLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREE 120
Query: 121 MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV 180
MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV
Sbjct: 121 MQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDV 180
Query: 181 ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI 240
ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI
Sbjct: 181 ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI 240
Query: 241 LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR 300
LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR
Sbjct: 241 LCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR 300
Query: 301 CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD 360
CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD
Sbjct: 301 CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAAD 360
Query: 361 ARYEAACNRLANKAVQRGSADNVTVMVVRIGH 392
ARYEAACNRLANKAVQRGSADNVTVMVVRIGH
Sbjct: 361 ARYEAACNRLANKAVQRGSADNVTVMVVRIGH 392
>gi|7661862 protein phosphatase 1F [Homo sapiens]
Length = 454
Score = 125 bits (314), Expect = 7e-29
Identities = 95/277 (34%), Positives = 143/277 (51%), Gaps = 31/277 (11%)
Query: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK 174
+ R +M+D HV L + S + R +YFAVFDGHGG+ A+++AA ++H N R+
Sbjct: 163 RNTRRKMEDRHVSLPSFNQ-LFGLSDPVNR-AYFAVFDGHGGVDAARYAAVHVHTNAARQ 220
Query: 175 FPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANL 234
+ + L + F+ TD+ FL++A ++ + G+T C L L++A L
Sbjct: 221 ------PELPTDPEGALREAFRRTDQMFLRKAKRER--LQSGTTGVCALIAGATLHVAWL 272
Query: 235 GDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRD---GRVLGVLEVSR 291
GDS+ IL Q+ + L + H P + +E+ RI+ GG V RV G L VSR
Sbjct: 273 GDSQVILV------QQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSR 326
Query: 292 SIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQ 351
+IGD +++ V+ D LT ++ ++LLACDG F V +E V + S L
Sbjct: 327 AIGD-VFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHL------ 379
Query: 352 TREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
TR+ S E L A +RGS DN+TVMVV
Sbjct: 380 TRQQGSGLRVAEE-----LVAAARERGSHDNITVMVV 411
>gi|30089948 protein phosphatase 1E [Homo sapiens]
Length = 755
Score = 122 bits (305), Expect = 7e-28
Identities = 92/281 (32%), Positives = 142/281 (50%), Gaps = 39/281 (13%)
Query: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK 174
K R +M+D HV + D +YFAVFDGHGG+ A+ +A+ +LH NL+R+
Sbjct: 238 KNMRRKMEDKHVCIPDFNMLFNLEDQ--EEQAYFAVFDGHGGVDAAIYASIHLHVNLVRQ 295
Query: 175 --FPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIA 232
FP L F+ TDE F+++A+ + + + G+T N+L++A
Sbjct: 296 EMFPHDPA--------EALCRAFRVTDERFVQKAA--RESLRCGTTGVVTFIRGNMLHVA 345
Query: 233 NLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNV---RDGRVLGVLEV 289
+GDS+ +L R K A+ L K H P + +E+ RI+ GG V RV G L V
Sbjct: 346 WVGDSQVMLVR------KGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSV 399
Query: 290 SRSIGDGQYKR--CGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
SR+IGD ++K CG D L + +++LACDG + P+EAV +
Sbjct: 400 SRAIGDAEHKPYICGDA---DSASTVLDGTEDYLILACDGFYDTVNPDEAVKVV-----S 451
Query: 348 EKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
+ ++ G S+ A ++L A GS+DN+TV+VV
Sbjct: 452 DHLKENNGDSSMVA------HKLVASARDAGSSDNITVIVV 486
>gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]
Length = 382
Score = 120 bits (302), Expect = 2e-27
Identities = 99/298 (33%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + + PS L + S+FAV+DGH G + +K+ +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVIGL------PSGLESW-SFFAVYDGHAGSQVAKYCCE 73
Query: 166 NLHQNLIRKFP-KGDV--ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCV 222
+L ++ KG SVE VK + F DE + + A + GSTA V
Sbjct: 74 HLLDHITNNQDFKGSAGAPSVEN-VKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 132
Query: 223 LAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGR 282
L Y N GDSR +LCR + +++H P+ E+ RIQ AGG+V R
Sbjct: 133 LISPQHTYFINCGDSRGLLCRNRKVH------FFTQDHKPSNPLEKERIQNAGGSVMIQR 186
Query: 283 VLGVLEVSRSIGDGQYKRC----GVT--------SVPDIRRCQLTPNDRFILLACDGLFK 330
V G L VSR++GD YK C G T V DI R + +D+FI+LACDG++
Sbjct: 187 VNGSLAVSRALGDFDYK-CVHGKGPTEQLVSPEPEVHDIERSE--EDDQFIILACDGIWD 243
Query: 331 VFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V EE +F+ S LE E CN + + + +GS DN++V+++
Sbjct: 244 VMGNEELCDFVRSRLE------------VTDDLEKVCNEVVDTCLYKGSRDNMSVILI 289
>gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]
Length = 324
Score = 120 bits (302), Expect = 2e-27
Identities = 99/298 (33%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + + PS L + S+FAV+DGH G + +K+ +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVIGL------PSGLESW-SFFAVYDGHAGSQVAKYCCE 73
Query: 166 NLHQNLIRKFP-KGDV--ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCV 222
+L ++ KG SVE VK + F DE + + A + GSTA V
Sbjct: 74 HLLDHITNNQDFKGSAGAPSVEN-VKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 132
Query: 223 LAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGR 282
L Y N GDSR +LCR + +++H P+ E+ RIQ AGG+V R
Sbjct: 133 LISPQHTYFINCGDSRGLLCRNRKVH------FFTQDHKPSNPLEKERIQNAGGSVMIQR 186
Query: 283 VLGVLEVSRSIGDGQYKRC----GVT--------SVPDIRRCQLTPNDRFILLACDGLFK 330
V G L VSR++GD YK C G T V DI R + +D+FI+LACDG++
Sbjct: 187 VNGSLAVSRALGDFDYK-CVHGKGPTEQLVSPEPEVHDIERSE--EDDQFIILACDGIWD 243
Query: 331 VFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V EE +F+ S LE E CN + + + +GS DN++V+++
Sbjct: 244 VMGNEELCDFVRSRLE------------VTDDLEKVCNEVVDTCLYKGSRDNMSVILI 289
>gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
Length = 455
Score = 120 bits (302), Expect = 2e-27
Identities = 99/298 (33%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + + PS L + S+FAV+DGH G + +K+ +
Sbjct: 94 GLRYGLSSMQGWRVEMEDAHTAVIGL------PSGLESW-SFFAVYDGHAGSQVAKYCCE 146
Query: 166 NLHQNLIRKFP-KGDV--ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCV 222
+L ++ KG SVE VK + F DE + + A + GSTA V
Sbjct: 147 HLLDHITNNQDFKGSAGAPSVEN-VKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 205
Query: 223 LAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGR 282
L Y N GDSR +LCR + +++H P+ E+ RIQ AGG+V R
Sbjct: 206 LISPQHTYFINCGDSRGLLCRNRKVH------FFTQDHKPSNPLEKERIQNAGGSVMIQR 259
Query: 283 VLGVLEVSRSIGDGQYKRC----GVT--------SVPDIRRCQLTPNDRFILLACDGLFK 330
V G L VSR++GD YK C G T V DI R + +D+FI+LACDG++
Sbjct: 260 VNGSLAVSRALGDFDYK-CVHGKGPTEQLVSPEPEVHDIERSE--EDDQFIILACDGIWD 316
Query: 331 VFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V EE +F+ S LE E CN + + + +GS DN++V+++
Sbjct: 317 VMGNEELCDFVRSRLE------------VTDDLEKVCNEVVDTCLYKGSRDNMSVILI 362
>gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]
Length = 360
Score = 115 bits (289), Expect = 5e-26
Identities = 90/288 (31%), Positives = 140/288 (48%), Gaps = 49/288 (17%)
Query: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNL--- 171
+G R+ M+D +L D+ + P S F +FDGHGG A+++ L + L
Sbjct: 99 QGRRDHMEDRFEVLTDLANKTHP--------SIFGIFDGHGGETAAEYVKSRLPEALKQH 150
Query: 172 ---IRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAV--D 226
K + V+S + +++ +L D E L++ + D + TC++A+ D
Sbjct: 151 LQDYEKDKENSVLSYQTILEQQILSI----DREMLEKLTVSY----DEAGTTCLIALLSD 202
Query: 227 NILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVR---DGRV 283
L +AN+GDSR +LC + A+ LS +H P Q +ER RI++AGG + RV
Sbjct: 203 KDLTVANVGDSRGVLC-----DKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRV 257
Query: 284 LGVLEVSRSIGDGQYKRCGVT-SVPDIRRCQLTP-NDRFILLACDGLFKVFTPEEAVNFI 341
G+L +SRS+GD K V PDI L F++LA DGL+ F+ EEAV FI
Sbjct: 258 QGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFI 317
Query: 342 LSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVR 389
L++ + + ++ RG DN+TVMVV+
Sbjct: 318 KERLDEPHFGAKS---------------IVLQSFYRGCPDNITVMVVK 350
>gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]
Length = 380
Score = 113 bits (283), Expect = 3e-25
Identities = 88/299 (29%), Positives = 138/299 (46%), Gaps = 42/299 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + I + S+FAV+DGH G R + + +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVVGIPHG-------LEDWSFFAVYDGHAGSRVANYCST 73
Query: 166 NLHQNLIR--------KFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGS 217
+L +++ K +SVE VK + F DE + + + GS
Sbjct: 74 HLLEHITTNEDFRAAGKSGSALELSVEN-VKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 218 TATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGN 277
TA V+ +Y N GDSRA+L R + +++H P E+ RIQ AGG+
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQ------VCFSTQDHKPCNPREKERIQNAGGS 186
Query: 278 VRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLF 329
V RV G L VSR++GD YK V+ P++ D FI+LACDG++
Sbjct: 187 VMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIW 246
Query: 330 KVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V + EE ++ S LE E CN + + + +GS DN+++++V
Sbjct: 247 DVMSNEELCEYVKSRLE------------VSDDLENVCNWVVDTCLHKGSRDNMSIVLV 293
>gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]
Length = 327
Score = 113 bits (283), Expect = 3e-25
Identities = 88/299 (29%), Positives = 138/299 (46%), Gaps = 42/299 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + I + S+FAV+DGH G R + + +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVVGIPHG-------LEDWSFFAVYDGHAGSRVANYCST 73
Query: 166 NLHQNLIR--------KFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGS 217
+L +++ K +SVE VK + F DE + + + GS
Sbjct: 74 HLLEHITTNEDFRAAGKSGSALELSVEN-VKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 218 TATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGN 277
TA V+ +Y N GDSRA+L R + +++H P E+ RIQ AGG+
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQ------VCFSTQDHKPCNPREKERIQNAGGS 186
Query: 278 VRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLF 329
V RV G L VSR++GD YK V+ P++ D FI+LACDG++
Sbjct: 187 VMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIW 246
Query: 330 KVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V + EE ++ S LE E CN + + + +GS DN+++++V
Sbjct: 247 DVMSNEELCEYVKSRLE------------VSDDLENVCNWVVDTCLHKGSRDNMSIVLV 293
>gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]
Length = 387
Score = 113 bits (283), Expect = 3e-25
Identities = 88/299 (29%), Positives = 138/299 (46%), Gaps = 42/299 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + I + S+FAV+DGH G R + + +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVVGIPHG-------LEDWSFFAVYDGHAGSRVANYCST 73
Query: 166 NLHQNLIR--------KFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGS 217
+L +++ K +SVE VK + F DE + + + GS
Sbjct: 74 HLLEHITTNEDFRAAGKSGSALELSVEN-VKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 218 TATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGN 277
TA V+ +Y N GDSRA+L R + +++H P E+ RIQ AGG+
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQ------VCFSTQDHKPCNPREKERIQNAGGS 186
Query: 278 VRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLF 329
V RV G L VSR++GD YK V+ P++ D FI+LACDG++
Sbjct: 187 VMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIW 246
Query: 330 KVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V + EE ++ S LE E CN + + + +GS DN+++++V
Sbjct: 247 DVMSNEELCEYVKSRLE------------VSDDLENVCNWVVDTCLHKGSRDNMSIVLV 293
>gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]
Length = 479
Score = 113 bits (283), Expect = 3e-25
Identities = 88/299 (29%), Positives = 138/299 (46%), Gaps = 42/299 (14%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ ++ +G R EM+DAH + I + S+FAV+DGH G R + + +
Sbjct: 21 GLRYGLSSMQGWRVEMEDAHTAVVGIPHG-------LEDWSFFAVYDGHAGSRVANYCST 73
Query: 166 NLHQNLIR--------KFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGS 217
+L +++ K +SVE VK + F DE + + + GS
Sbjct: 74 HLLEHITTNEDFRAAGKSGSALELSVEN-VKNGIRTGFLKIDEYMRNFSDLRNGMDRSGS 132
Query: 218 TATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGN 277
TA V+ +Y N GDSRA+L R + +++H P E+ RIQ AGG+
Sbjct: 133 TAVGVMISPKHIYFINCGDSRAVLYRNGQ------VCFSTQDHKPCNPREKERIQNAGGS 186
Query: 278 VRDGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLF 329
V RV G L VSR++GD YK V+ P++ D FI+LACDG++
Sbjct: 187 VMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIW 246
Query: 330 KVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
V + EE ++ S LE E CN + + + +GS DN+++++V
Sbjct: 247 DVMSNEELCEYVKSRLE------------VSDDLENVCNWVVDTCLHKGSRDNMSIVLV 293
>gi|167466276 protein phosphatase 1K (PP2C domain containing) [Homo
sapiens]
Length = 372
Score = 112 bits (279), Expect = 8e-25
Identities = 83/262 (31%), Positives = 130/262 (49%), Gaps = 37/262 (14%)
Query: 139 SSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHT 198
+ L V YFAV+DGHGG A+ F ++ + ++ PK EK ++ L F
Sbjct: 114 AQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPK------EKNLETLLTLAFLEI 167
Query: 199 DEEFLKQA--SSQKPAWKDGSTATCVLAVDNI-LYIANLGDSRAILCRYNEESQKHAALS 255
D+ F A S+ G+TAT L D I L +A++GDSRAILCR K +
Sbjct: 168 DKAFSSHARLSADATLLTSGTTATVALLRDGIELVVASVGDSRAILCR------KGKPMK 221
Query: 256 LSKEHNPTQYEERMRIQKAGG-----NVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIR 310
L+ +H P + +E+ RI+K GG ++ V G L ++RSIGD K GV + P+ +
Sbjct: 222 LTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETK 281
Query: 311 RCQL-TPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNR 369
R +L +D F++L DG+ + +E +F+ C + + A +
Sbjct: 282 RIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNE----------------AAHA 325
Query: 370 LANKAVQRGSADNVTVMVVRIG 391
+ +A+Q G+ DN T +VV G
Sbjct: 326 VTEQAIQYGTEDNSTAVVVPFG 347
>gi|122937199 protein phosphatase 1B-like [Homo sapiens]
Length = 430
Score = 105 bits (263), Expect = 5e-23
Identities = 89/291 (30%), Positives = 134/291 (46%), Gaps = 38/291 (13%)
Query: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
GL+ + +G R M+DAH + PP + FAV DGHGG RA++F A+
Sbjct: 64 GLRFGASAAQGWRARMEDAHCTWLSLPG--LPPGWAL-----FAVLDGHGGARAARFGAR 116
Query: 166 NLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAV 225
+L +++++ G S + V+ L F DE S G TA +L
Sbjct: 117 HLPGHVLQEL--GPEPSEPEGVREALRRAFLSADERL---RSLWPRVETGGCTAVVLLVS 171
Query: 226 DNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLG 285
LY+A+ GDSRA+L R A +++H P + ER RI AGG +R RV G
Sbjct: 172 PRFLYLAHCGDSRAVLSRAG------AVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEG 225
Query: 286 VLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEA 337
L VSR++GD YK V++ P++ D F+LLA DG++ +
Sbjct: 226 SLAVSRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDEFMLLASDGVWDTVSGAAL 285
Query: 338 VNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
+ S L R G + E C +L + + +GS DN+T ++V
Sbjct: 286 AGLVASRL-------RLGLAP-----ELLCAQLLDTCLCKGSLDNMTCILV 324
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 89.0 bits (219), Expect = 7e-18
Identities = 55/144 (38%), Positives = 81/144 (56%), Gaps = 15/144 (10%)
Query: 209 QKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEER 268
++P G+TA L L +AN GDSR ++ S+ AL +S +H P E
Sbjct: 321 EEPGSDSGTTAVVALIRGKQLIVANAGDSRCVV------SEAGKALDMSYDHKPEDEVEL 374
Query: 269 MRIQKAGGNVR-DGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDR 319
RI+ AGG V DGRV G L +SR+IGD YKR ++++PDI+ LT +
Sbjct: 375 ARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHE 434
Query: 320 FILLACDGLFKVFTPEEAVNFILS 343
F+++ACDG++ V + +E V+FI S
Sbjct: 435 FMVIACDGIWNVMSSQEVVDFIQS 458
Score = 32.3 bits (72), Expect = 0.76
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 20/96 (20%)
Query: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK 174
+G R M+DAH + ++ E + F+V+DGHGG + + A+ L +
Sbjct: 33 QGWRVSMEDAHNCIPELDSE----------TAMFSVYDGHGGEEVALYCAKYLPDII--- 79
Query: 175 FPKGDVISVEKTVKRCLLDTF-----KHTDEEFLKQ 205
K E +++ L D F K T EE +K+
Sbjct: 80 --KDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKE 113
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 89.0 bits (219), Expect = 7e-18
Identities = 55/144 (38%), Positives = 81/144 (56%), Gaps = 15/144 (10%)
Query: 209 QKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEER 268
++P G+TA L L +AN GDSR ++ S+ AL +S +H P E
Sbjct: 321 EEPGSDSGTTAVVALIRGKQLIVANAGDSRCVV------SEAGKALDMSYDHKPEDEVEL 374
Query: 269 MRIQKAGGNVR-DGRVLGVLEVSRSIGDGQYKRCG--------VTSVPDIRRCQLTPNDR 319
RI+ AGG V DGRV G L +SR+IGD YKR ++++PDI+ LT +
Sbjct: 375 ARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHE 434
Query: 320 FILLACDGLFKVFTPEEAVNFILS 343
F+++ACDG++ V + +E V+FI S
Sbjct: 435 FMVIACDGIWNVMSSQEVVDFIQS 458
Score = 32.3 bits (72), Expect = 0.76
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 20/96 (20%)
Query: 115 KGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRK 174
+G R M+DAH + ++ E + F+V+DGHGG + + A+ L +
Sbjct: 33 QGWRVSMEDAHNCIPELDSE----------TAMFSVYDGHGGEEVALYCAKYLPDII--- 79
Query: 175 FPKGDVISVEKTVKRCLLDTF-----KHTDEEFLKQ 205
K E +++ L D F K T EE +K+
Sbjct: 80 --KDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKE 113
>gi|4505997 protein phosphatase 1D [Homo sapiens]
Length = 605
Score = 70.5 bits (171), Expect = 3e-12
Identities = 75/297 (25%), Positives = 132/297 (44%), Gaps = 54/297 (18%)
Query: 135 CRPPSSLITRVSYFAVFDGHGGIRASKFAAQNL------HQNLIRKFPKGDVISVEKTVK 188
CR SS V++FAV DGHGG A++FA ++L + P ++ K
Sbjct: 92 CRRRSS----VAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFL 147
Query: 189 RCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEES 248
C L +K E + + P+ G+TA+ V+ +Y+A++GDS +L ++
Sbjct: 148 ACHLAMWKKLAE--WPKTMTGLPS-TSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPK 204
Query: 249 QKHA-ALSLSKEHNPTQYEERMRIQKAGGNVRD----GRV-------------------- 283
A+ ++++H P +ER RI+ GG+V + RV
Sbjct: 205 DDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVID 264
Query: 284 -LGVLEVSRSIGD--------GQYKRCGVTSVPDIRRCQLTPND-RFILLACDGLFKVFT 333
+ L V+R++GD G++ V+ PD L P ++I+L DGL+ +
Sbjct: 265 QIPFLAVARALGDLWSYDFFSGEFV---VSPEPDTSVHTLDPQKHKYIILGSDGLWNMIP 321
Query: 334 PEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRI 390
P++A++ E + + G+S A A R + ++ ADN + +V+ I
Sbjct: 322 PQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLR---ADNTSAIVICI 375
>gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 51/209 (24%)
Query: 182 SVEKTVKRCLLDTFKHTDEEFLKQASSQKP----------AWKDGSTATCVLAVDNI-LY 230
S + VK L++ FK D + +A P G+TA CV VD + L+
Sbjct: 227 STDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATA-CVAHVDGVDLH 285
Query: 231 IANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQ------KAGGNVRDGRVL 284
+AN GDSRA+L EE +A++LS +HN E R++ +A V+ R+L
Sbjct: 286 VANTGDSRAML-GVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLL 344
Query: 285 GVLEVSRSIGDGQYK----------RCG----------------------VTSVPDIRRC 312
G+L R+ GD ++K G +T+ P++
Sbjct: 345 GLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYH 404
Query: 313 QLTPNDRFILLACDGLFKVFTPEEAVNFI 341
+L P D+F++LA DGL++ ++ V +
Sbjct: 405 RLRPQDKFLVLATDGLWETMHRQDVVRIV 433
>gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 51/209 (24%)
Query: 182 SVEKTVKRCLLDTFKHTDEEFLKQASSQKP----------AWKDGSTATCVLAVDNI-LY 230
S + VK L++ FK D + +A P G+TA CV VD + L+
Sbjct: 227 STDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATA-CVAHVDGVDLH 285
Query: 231 IANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQ------KAGGNVRDGRVL 284
+AN GDSRA+L EE +A++LS +HN E R++ +A V+ R+L
Sbjct: 286 VANTGDSRAML-GVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLL 344
Query: 285 GVLEVSRSIGDGQYK----------RCG----------------------VTSVPDIRRC 312
G+L R+ GD ++K G +T+ P++
Sbjct: 345 GLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYH 404
Query: 313 QLTPNDRFILLACDGLFKVFTPEEAVNFI 341
+L P D+F++LA DGL++ ++ V +
Sbjct: 405 RLRPQDKFLVLATDGLWETMHRQDVVRIV 433
>gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 51/209 (24%)
Query: 182 SVEKTVKRCLLDTFKHTDEEFLKQASSQKP----------AWKDGSTATCVLAVDNI-LY 230
S + VK L++ FK D + +A P G+TA CV VD + L+
Sbjct: 252 STDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATA-CVAHVDGVDLH 310
Query: 231 IANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQ------KAGGNVRDGRVL 284
+AN GDSRA+L EE +A++LS +HN E R++ +A V+ R+L
Sbjct: 311 VANTGDSRAML-GVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLL 369
Query: 285 GVLEVSRSIGDGQYK----------RCG----------------------VTSVPDIRRC 312
G+L R+ GD ++K G +T+ P++
Sbjct: 370 GLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYH 429
Query: 313 QLTPNDRFILLACDGLFKVFTPEEAVNFI 341
+L P D+F++LA DGL++ ++ V +
Sbjct: 430 RLRPQDKFLVLATDGLWETMHRQDVVRIV 458
>gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 51/209 (24%)
Query: 182 SVEKTVKRCLLDTFKHTDEEFLKQASSQKP----------AWKDGSTATCVLAVDNI-LY 230
S + VK L++ FK D + +A P G+TA CV VD + L+
Sbjct: 252 STDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATA-CVAHVDGVDLH 310
Query: 231 IANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQ------KAGGNVRDGRVL 284
+AN GDSRA+L EE +A++LS +HN E R++ +A V+ R+L
Sbjct: 311 VANTGDSRAML-GVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLL 369
Query: 285 GVLEVSRSIGDGQYK----------RCG----------------------VTSVPDIRRC 312
G+L R+ GD ++K G +T+ P++
Sbjct: 370 GLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYH 429
Query: 313 QLTPNDRFILLACDGLFKVFTPEEAVNFI 341
+L P D+F++LA DGL++ ++ V +
Sbjct: 430 RLRPQDKFLVLATDGLWETMHRQDVVRIV 458
>gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 1 [Homo sapiens]
Length = 596
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 51/209 (24%)
Query: 182 SVEKTVKRCLLDTFKHTDEEFLKQASSQKP----------AWKDGSTATCVLAVDNI-LY 230
S + VK L++ FK D + +A P G+TA CV VD + L+
Sbjct: 286 STDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATA-CVAHVDGVDLH 344
Query: 231 IANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQ------KAGGNVRDGRVL 284
+AN GDSRA+L EE +A++LS +HN E R++ +A V+ R+L
Sbjct: 345 VANTGDSRAML-GVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLL 403
Query: 285 GVLEVSRSIGDGQYK----------RCG----------------------VTSVPDIRRC 312
G+L R+ GD ++K G +T+ P++
Sbjct: 404 GLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYH 463
Query: 313 QLTPNDRFILLACDGLFKVFTPEEAVNFI 341
+L P D+F++LA DGL++ ++ V +
Sbjct: 464 RLRPQDKFLVLATDGLWETMHRQDVVRIV 492
>gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo
sapiens]
Length = 529
Score = 56.6 bits (135), Expect = 4e-08
Identities = 47/170 (27%), Positives = 79/170 (46%), Gaps = 40/170 (23%)
Query: 216 GSTATCVLAVDNI-LYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKA 274
G+TA C+ VD I L++AN GD RAIL E++ + L L+++HN E R+++
Sbjct: 266 GATA-CMAHVDGIHLHVANAGDCRAIL-GVQEDNGMWSCLPLTRDHNAWNQAELSRLKRE 323
Query: 275 GGN------VRDGRVLGVLEVSRSIGDGQ------------------------------- 297
+ + R+LGVL R+ GD Q
Sbjct: 324 HPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHY 383
Query: 298 YKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLED 347
Y +T+ P++ +L P D+F++LA DGL+ + + E+ V ++ L +
Sbjct: 384 YTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAE 433
>gi|5174703 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform alpha [Homo sapiens]
Length = 504
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/279 (22%), Positives = 113/279 (40%), Gaps = 65/279 (23%)
Query: 148 FAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQAS 207
+ VF+G+ G R + F AQ L L+ + + E V+R LL F + FL+
Sbjct: 65 YGVFNGYDGNRVTNFVAQRLSAELL--LGQLNAEHAEADVRRVLLQAFDVVERSFLESID 122
Query: 208 ----------SQKPAW------------------------KDGSTATCVLAVDNILYIAN 233
SQ P G+ A + ++N LY+AN
Sbjct: 123 DALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVAN 182
Query: 234 LGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAG---GNVRDGRVLGVLEVS 290
+G +RA+LC+ + + L+ +H +E R+ + G G ++ ++ E +
Sbjct: 183 VGTNRALLCKSTVDGLQ--VTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST 240
Query: 291 RSIGDGQYKRCGVTSV--------------PDIRRCQ-LTPNDRFILLACDGLFKVFT-- 333
R IGD + K G T + P+I Q L F++L +GL+K
Sbjct: 241 RRIGDYKVK-YGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAA 299
Query: 334 --PEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRL 370
P +A I + ++ E + +++ DA +A +R+
Sbjct: 300 HGPGQANQEIAAMIDTEFAK----QTSLDAVAQAVVDRV 334
>gi|41281798 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform beta [Homo sapiens]
Length = 462
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/279 (22%), Positives = 113/279 (40%), Gaps = 65/279 (23%)
Query: 148 FAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQAS 207
+ VF+G+ G R + F AQ L L+ + + E V+R LL F + FL+
Sbjct: 65 YGVFNGYDGNRVTNFVAQRLSAELL--LGQLNAEHAEADVRRVLLQAFDVVERSFLESID 122
Query: 208 ----------SQKPAW------------------------KDGSTATCVLAVDNILYIAN 233
SQ P G+ A + ++N LY+AN
Sbjct: 123 DALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVAN 182
Query: 234 LGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAG---GNVRDGRVLGVLEVS 290
+G +RA+LC+ + + L+ +H +E R+ + G G ++ ++ E +
Sbjct: 183 VGTNRALLCKSTVDGLQ--VTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST 240
Query: 291 RSIGDGQYKRCGVTSV--------------PDIRRCQ-LTPNDRFILLACDGLFKVFT-- 333
R IGD + K G T + P+I Q L F++L +GL+K
Sbjct: 241 RRIGDYKVK-YGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAA 299
Query: 334 --PEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRL 370
P +A I + ++ E + +++ DA +A +R+
Sbjct: 300 HGPGQANQEIAAMIDTEFAK----QTSLDAVAQAVVDRV 334
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 51.2 bits (121), Expect = 2e-06
Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 232 ANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNV-RDGRVLGVLEVS 290
AN+G + +LCR + L LS+ + + EE RI++ + DG+V GV E +
Sbjct: 774 ANVGKCQTVLCRNGKP------LPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTEST 827
Query: 291 RSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKI 350
R +G + V P ++ LTP D F +L GL+ + EEAV +
Sbjct: 828 RILGY-TFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAV--------- 877
Query: 351 QTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRI 390
++ DA AA +L A G D+++ +VV++
Sbjct: 878 -----RNVPDAL--AAAKKLCTLAQSYGCHDSISAVVVQL 910
>gi|149944715 protein phosphatase 1H (PP2C domain containing) [Homo
sapiens]
Length = 514
Score = 45.8 bits (107), Expect = 7e-05
Identities = 62/269 (23%), Positives = 106/269 (39%), Gaps = 71/269 (26%)
Query: 191 LLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNE---- 246
L FK D + ++ SS + G TA V+ + LY+AN GDSRAI+ R E
Sbjct: 245 LESAFKEMDLQIERERSSYNIS--GGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPM 302
Query: 247 --------ESQKHAALS------LSKEHNPTQYEERMRIQKAG----------------- 275
E Q+ L+ L E ++ R++ ++ G
Sbjct: 303 SSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKT 362
Query: 276 ------------GNVRDGRVLGVLEVSRSIGDGQ--------YKRCGVTSVPDIRRCQLT 315
G + RV+ + V+R +GD Y + ++S P++R L+
Sbjct: 363 IEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLS 422
Query: 316 P----NDRFILLACDGLFKVFTPEEA----VNFILSCLEDEKIQTREGKSAADARYEAAC 367
+D ++LA DGL+ V + EE F+ +C D+ + R
Sbjct: 423 KYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVL 482
Query: 368 N----RLANKAVQRGSADNVTVMVVRIGH 392
R++N + GS D+++V V+ + H
Sbjct: 483 KDRGWRISNDRL--GSGDDISVYVIPLIH 509
>gi|171460932 protein phosphatase 1M isoform a [Homo sapiens]
Length = 298
Score = 45.1 bits (105), Expect = 1e-04
Identities = 57/225 (25%), Positives = 91/225 (40%), Gaps = 63/225 (28%)
Query: 181 ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAI 240
I E V L F+ DE ++ + G TA +++ LY+AN GDSRAI
Sbjct: 21 IRAEDLVIGALESAFQECDEVIGRELEAS--GQMGGCTALVAVSLQGKLYMANAGDSRAI 78
Query: 241 LCRYNE------------ESQKHAALS------LSKEHNPTQYEERM------------- 269
L R +E E Q+ L+ L+ E ++ R+
Sbjct: 79 LVRRDEIRPLSFEFTPETERQRIQQLAFVYPELLAGEFTRLEFPRRLKGDDLGQKVLFRD 138
Query: 270 ---------RIQKAG-------GNVRDGRVLGVLEVSRSIGDGQYK--------RCGVTS 305
R++K+ G R R+LG L VSR +GD Q + + + S
Sbjct: 139 HHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLS 198
Query: 306 VP-----DIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCL 345
VP D+ + +L +D +++A DGL+ V + E+ + S L
Sbjct: 199 VPQVTVLDVDQLELQEDD-VVVMATDGLWDVLSNEQVAWLVRSFL 242
>gi|171460934 protein phosphatase 1M isoform b [Homo sapiens]
Length = 247
Score = 43.5 bits (101), Expect = 3e-04
Identities = 50/190 (26%), Positives = 80/190 (42%), Gaps = 61/190 (32%)
Query: 216 GSTATCVLAVDNILYIANLGDSRAILCRYNE------------ESQKHAALS------LS 257
G TA +++ LY+AN GDSRAIL R +E E Q+ L+ L+
Sbjct: 3 GCTALVAVSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPETERQRIQQLAFVYPELLA 62
Query: 258 KEHNPTQYEERM----------------------RIQKAG-------GNVRDGRVLGVLE 288
E ++ R+ R++K+ G R R+LG L
Sbjct: 63 GEFTRLEFPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLA 122
Query: 289 VSRSIGDGQYK--------RCGVTSVP-----DIRRCQLTPNDRFILLACDGLFKVFTPE 335
VSR +GD Q + + + SVP D+ + +L +D +++A DGL+ V + E
Sbjct: 123 VSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDD-VVVMATDGLWDVLSNE 181
Query: 336 EAVNFILSCL 345
+ + S L
Sbjct: 182 QVAWLVRSFL 191
>gi|65506328 protein phosphatase 1J (PP2C domain containing) [Homo
sapiens]
Length = 505
Score = 41.2 bits (95), Expect = 0.002
Identities = 76/351 (21%), Positives = 126/351 (35%), Gaps = 110/351 (31%)
Query: 147 YFAVFDGHGGIRASKFAAQNLHQNLIRK-------------------------------- 174
Y+ +FDGH G A++ A++ LH+++ +
Sbjct: 153 YWGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDPSH 212
Query: 175 -------FPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDN 227
+ +S E V + + F+ DE+ ++ + + G A V+ +
Sbjct: 213 LLGPQSCWSSQKEVSHESLVVGAVENAFQLMDEQMARERRGHQV--EGGCCALVVIYLLG 270
Query: 228 ILYIANLGDSRAILCRYNE------------ESQKHAALS-------------------- 255
+Y+AN GDSRAI+ R E E Q+ L
Sbjct: 271 KVYVANAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRV 330
Query: 256 ---------LSKEHNPTQYE------ERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKR 300
L ++ N T + E +R G + RV+ + V+R +GD K
Sbjct: 331 LPKELGQRMLYRDQNMTGWAYKKIELEDLRFPLVCGEGKKARVMATIGVTRGLGDHSLKV 390
Query: 301 CGVT--------SVPDIRRCQLTP----NDRFILLACDGLFKVFTPEE---AVNFILSCL 345
C T P++R LT D ++L DGL+ V T E V+ +LS
Sbjct: 391 CSSTLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATVDRVLSAY 450
Query: 346 E--DEKIQTREGKS---AADARYEAACNRLANKAVQRGSADNVTVMVVRIG 391
E D T ++ A RL N + GS D+++V V+ +G
Sbjct: 451 EPNDHSRYTALAQALVLGARGTPRDRGWRLPNNKL--GSGDDISVFVIPLG 499
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 40.0 bits (92), Expect = 0.004
Identities = 44/160 (27%), Positives = 65/160 (40%), Gaps = 21/160 (13%)
Query: 229 LYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLE 288
L +AN+G +A+LCR + SL ++ Q R++ QKA D +V GV
Sbjct: 893 LTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQ---RVKDQKA-IITEDNKVNGVTC 948
Query: 289 VSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDE 348
+R +G Y + P I LT D ++L L++ + EAVN + +
Sbjct: 949 CTRMLG-CTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDP- 1006
Query: 349 KIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
AA +L A G DNV MVV
Sbjct: 1007 ---------------LAAAKKLCTLAQSYGCQDNVGAMVV 1031
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,308,075
Number of Sequences: 37866
Number of extensions: 712636
Number of successful extensions: 2927
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 2781
Number of HSP's gapped (non-prelim): 99
length of query: 392
length of database: 18,247,518
effective HSP length: 104
effective length of query: 288
effective length of database: 14,309,454
effective search space: 4121122752
effective search space used: 4121122752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.