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Search of human proteins with 13518013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13518013 ataxin 3 isoform 2 [Homo sapiens]
(306 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13518013 ataxin 3 isoform 2 [Homo sapiens] 605 e-173
gi|13518019 ataxin 3 isoform 1 [Homo sapiens] 589 e-168
gi|189163493 ataxin 3 isoform 3 [Homo sapiens] 560 e-160
gi|189163495 ataxin 3 isoform 4 [Homo sapiens] 457 e-129
gi|209862748 ataxin 3-like [Homo sapiens] 370 e-102
gi|221139761 zinc finger protein 853 [Homo sapiens] 50 3e-06
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 45 6e-05
gi|33286444 mastermind-like 2 [Homo sapiens] 45 6e-05
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 45 1e-04
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 44 2e-04
gi|56549694 enabled homolog isoform a [Homo sapiens] 42 5e-04
gi|39930375 enabled homolog isoform b [Homo sapiens] 42 5e-04
gi|148746195 trichohyalin [Homo sapiens] 42 5e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 42 5e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 42 5e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 42 5e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 42 5e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 42 5e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 42 5e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 42 5e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 42 5e-04
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 42 7e-04
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 42 7e-04
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 42 7e-04
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 42 7e-04
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 41 0.001
gi|14149997 neuroblastoma breakpoint family, member 3 [Homo sapi... 41 0.002
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 40 0.003
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 40 0.003
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 40 0.003
>gi|13518013 ataxin 3 isoform 2 [Homo sapiens]
Length = 306
Score = 605 bits (1559), Expect = e-173
Identities = 306/306 (100%), Positives = 306/306 (100%)
Query: 1 MESIFHEKQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICN 60
MESIFHEKQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICN
Sbjct: 1 MESIFHEKQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICN 60
Query: 61 YKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEAD 120
YKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEAD
Sbjct: 61 YKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEAD 120
Query: 121 QLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL 180
QLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL
Sbjct: 121 QLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL 180
Query: 181 SRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQK 240
SRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQK
Sbjct: 181 SRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQK 240
Query: 241 QQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDL 300
QQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDL
Sbjct: 241 QQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDL 300
Query: 301 KTEGKK 306
KTEGKK
Sbjct: 301 KTEGKK 306
>gi|13518019 ataxin 3 isoform 1 [Homo sapiens]
Length = 361
Score = 589 bits (1518), Expect = e-168
Identities = 298/299 (99%), Positives = 299/299 (100%)
Query: 8 KQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFT 67
+QPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFT
Sbjct: 63 QQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFT 122
Query: 68 VRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIR 127
VRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIR
Sbjct: 123 VRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIR 182
Query: 128 VQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDM 187
VQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDM
Sbjct: 183 VQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDM 242
Query: 188 EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQ 247
EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQ
Sbjct: 243 EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQ 302
Query: 248 QQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 306
QQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK
Sbjct: 303 QQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 361
>gi|189163493 ataxin 3 isoform 3 [Homo sapiens]
Length = 346
Score = 560 bits (1444), Expect = e-160
Identities = 284/285 (99%), Positives = 285/285 (100%)
Query: 22 IQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSL 81
+QVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSL
Sbjct: 62 LQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSL 121
Query: 82 LTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEEL 141
LTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEEL
Sbjct: 122 LTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEEL 181
Query: 142 AQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLS 201
AQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLS
Sbjct: 182 AQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLS 241
Query: 202 MQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPC 261
MQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPC
Sbjct: 242 MQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPC 301
Query: 262 ERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 306
ERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK
Sbjct: 302 ERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 346
>gi|189163495 ataxin 3 isoform 4 [Homo sapiens]
Length = 295
Score = 457 bits (1175), Expect = e-129
Identities = 252/319 (78%), Positives = 262/319 (82%), Gaps = 37/319 (11%)
Query: 1 MESIFHEKQPSG--------NMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLR---- 48
MESIFHEKQ N+ +FS +S+ I E +R+R
Sbjct: 1 MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSS---------IAHQLDEEERMRMAEG 51
Query: 49 -IDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSI 107
+ + R+F+ QWFNLNSLLTGPELISDTYLALFLAQLQQEGYSI
Sbjct: 52 GVTSEDYRTFL---------------QWFNLNSLLTGPELISDTYLALFLAQLQQEGYSI 96
Query: 108 FVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGML 167
FVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGML
Sbjct: 97 FVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGML 156
Query: 168 DEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELR 227
DEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELR
Sbjct: 157 DEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELR 216
Query: 228 KRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQA 287
KRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQA
Sbjct: 217 KRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQA 276
Query: 288 AVTMSLETVRNDLKTEGKK 306
AVTMSLETVRNDLKTEGKK
Sbjct: 277 AVTMSLETVRNDLKTEGKK 295
>gi|209862748 ataxin 3-like [Homo sapiens]
Length = 355
Score = 370 bits (949), Expect = e-102
Identities = 196/299 (65%), Positives = 233/299 (77%), Gaps = 6/299 (2%)
Query: 8 KQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFT 67
+QPS NMDD+GFFSIQVISNALK WGLE+I FN+PEYQ+L IDPINERSFICNYK+HWFT
Sbjct: 63 QQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFT 122
Query: 68 VRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIR 127
+RK GK WFNLNSLL GPELISDT LA FLA+LQQ+ YS+FVVKGDLPDCEADQLLQ+I
Sbjct: 123 IRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIIS 182
Query: 128 VQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDM 187
V++M PKL G++L + KE RV+KT LE+V E +D SG D+DEED QRAL LSRQE +
Sbjct: 183 VEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNR 242
Query: 188 EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQ 247
EDE LR I+LSMQGSS N SQD+ +TS SE+ +K +E YFEK QQ+Q+QQ
Sbjct: 243 EDEH--LRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH---QQEQKQQ 297
Query: 248 QQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 306
QQQ DL G SS+ ERP TSS A+ SDL D +S E +QAAV LE +R +LK +G+K
Sbjct: 298 QQQSDLPGHSSYLHERPTTSSRAIESDLSDDIS-EGTVQAAVDTILEIMRKNLKIKGEK 355
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 49.7 bits (117), Expect = 3e-06
Identities = 47/211 (22%), Positives = 89/211 (42%), Gaps = 21/211 (9%)
Query: 97 LAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDL-- 154
L+QLQQE + + P+ + Q ++ QQ+ + + ++ QL+ Q+ + +
Sbjct: 130 LSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQ 189
Query: 155 --ERVLEANDGSGMLDEDEEDLQRALALSRQEI----DMEDEEADLRRAIQLSMQGSSRN 208
E++ + +L + +E LQ+ L +QE + ++ L++ QL +
Sbjct: 190 QQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQ 249
Query: 209 ISQDMTQTSGTNLTSEELRKRR-----------EAYFEKQQQKQ--QQQQQQQQQGDLSG 255
+ Q + Q L + L +++ + ++QQQ+Q QQQQ+Q QQ L
Sbjct: 250 LQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQP 309
Query: 256 QSSHPCERPATSSGALGSDLGDAMSEEDMLQ 286
P E + DLG E Q
Sbjct: 310 PPLEPEEEEEVELELMPVDLGSEQELEQQRQ 340
Score = 47.0 bits (110), Expect = 2e-05
Identities = 36/136 (26%), Positives = 63/136 (46%), Gaps = 9/136 (6%)
Query: 115 PDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDL 174
P E Q Q QQ+ +L Q K Q VH +L+ L+ L + +
Sbjct: 114 PHLELQQQPQQDGQQQL-------SQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQ--V 164
Query: 175 QRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYF 234
Q L +Q+ ++ ++A ++ +Q Q + Q + Q L ++L +++E
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQ 224
Query: 235 EKQQQKQQQQQQQQQQ 250
++Q Q+QQ+Q QQQQQ
Sbjct: 225 QQQFQQQQEQLQQQQQ 240
Score = 36.2 bits (82), Expect = 0.037
Identities = 31/133 (23%), Positives = 63/133 (47%), Gaps = 23/133 (17%)
Query: 122 LLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALS 181
L Q ++QQ + +L+ ++ QL++Q++ LE +E+E +L+
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPE----------EEEEVELELMPVDL 329
Query: 182 RQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQ 241
E ++E + +L R +L Q R + + EEL++ + + +Q+Q
Sbjct: 330 GSEQELEQQRQELERQQELERQQEQRQLQLKL---------QEELQQLEQ----QLEQQQ 376
Query: 242 QQQQQQQQQGDLS 254
QQ +QQ+ Q +L+
Sbjct: 377 QQLEQQEVQLELT 389
Score = 35.8 bits (81), Expect = 0.049
Identities = 32/130 (24%), Positives = 60/130 (46%), Gaps = 5/130 (3%)
Query: 121 QLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALAL 180
QLLQ + Q + L+ ++ AQL++Q + + + L+ +L + +E LQ+
Sbjct: 253 QLLQQQQAQLQQQ--LLEQQQAQLQQQLLLQQ--QEQLQQQQQQQLLQQQQEQLQQQQLQ 308
Query: 181 SRQEIDMEDEEADLR-RAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQ 239
E+EE +L + L + Q++ + E+ + + + E QQ
Sbjct: 309 PPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQL 368
Query: 240 KQQQQQQQQQ 249
+QQ +QQQQQ
Sbjct: 369 EQQLEQQQQQ 378
Score = 35.0 bits (79), Expect = 0.083
Identities = 36/179 (20%), Positives = 77/179 (43%), Gaps = 12/179 (6%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHK--TDLER 156
QLQQ+ + + + Q L +++ Q + +L+ ++ AQL++Q + + L++
Sbjct: 222 QLQQQQF-----QQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ 276
Query: 157 VLEANDGSGMLDEDEEDL--QRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMT 214
L + + ++ L Q+ L +Q++ E + ++L + Q++
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELE 336
Query: 215 QTSGTNLTSEELRKR---REAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGA 270
Q +EL ++ R+ + Q++ QQ +QQ +QQ Q E GA
Sbjct: 337 QQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGA 395
Score = 31.2 bits (69), Expect = 1.2
Identities = 23/135 (17%), Positives = 60/135 (44%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQ 175
+ + QL Q QQ + + + + L+ Q+ + D ++ L ++L+
Sbjct: 88 ELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELK 147
Query: 176 RALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFE 235
L L Q+ ++ ++ ++ +Q + +Q+ +++++++ +
Sbjct: 148 PELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQ 207
Query: 236 KQQQKQQQQQQQQQQ 250
++Q +QQQ QQQ+Q
Sbjct: 208 QEQLQQQQLLQQQEQ 222
Score = 30.8 bits (68), Expect = 1.6
Identities = 32/136 (23%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 138 GEELAQLKEQRVHKTDLER-VLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRR 196
G E + +E + + +R + A G+ + E+ QR L L + E E ++
Sbjct: 48 GSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHE 107
Query: 197 AIQLSM----------QGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQ----QKQQ 242
+Q Q + +SQ + Q ++ +EL+ + ++QQ Q Q+
Sbjct: 108 QLQQPQPHLELQQQPQQDGQQQLSQ-LQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQE 166
Query: 243 QQQQQQQQGDLSGQSS 258
QQ+ QQQQ L Q +
Sbjct: 167 QQRLQQQQEQLQTQQA 182
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 45.4 bits (106), Expect = 6e-05
Identities = 30/78 (38%), Positives = 41/78 (52%), Gaps = 2/78 (2%)
Query: 175 QRALALSRQ--EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREA 232
Q+ L SRQ E+ ME+ A ++ MQ ++ M L S R++R A
Sbjct: 1181 QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVA 1240
Query: 233 YFEKQQQKQQQQQQQQQQ 250
+QQQ+QQQQQQQQQQ
Sbjct: 1241 MMMQQQQQQQQQQQQQQQ 1258
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 45.4 bits (106), Expect = 6e-05
Identities = 26/90 (28%), Positives = 44/90 (48%)
Query: 178 LALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQ 237
L ++Q+ + ++ ++ Q Q + Q Q+S + ++ + A ++Q
Sbjct: 584 LHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQ 643
Query: 238 QQKQQQQQQQQQQGDLSGQSSHPCERPATS 267
QQ+QQQQQQQQQQ Q P +PA S
Sbjct: 644 QQQQQQQQQQQQQQQQQQQQQQPSSQPAQS 673
Score = 45.1 bits (105), Expect = 8e-05
Identities = 27/106 (25%), Positives = 56/106 (52%), Gaps = 2/106 (1%)
Query: 157 VLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQT 216
VL + + +L ++ Q+ +Q+ + ++ ++ Q Q SS + Q Q
Sbjct: 574 VLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQ 633
Query: 217 SGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCE 262
S ++++++ +++++ ++QQQ+QQQQQQQQQQ S P +
Sbjct: 634 S--SISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQ 677
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/173 (19%), Positives = 71/173 (41%), Gaps = 16/173 (9%)
Query: 114 LPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEED 173
LP LL + QQ + + ++ Q ++Q+ + ++ + S + + ++
Sbjct: 575 LPSQNKPSLLHYTQQQQQQQQQ---QQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQ 631
Query: 174 LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAY 233
Q +++ +Q+ + ++ ++ Q Q + SQ L L +++
Sbjct: 632 QQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLL 691
Query: 234 FEKQQQK-------QQQQQQQQQQGDLSGQ------SSHPCERPATSSGALGS 273
++ Q + Q QQQ+Q Q + GQ S +PC P T SG + S
Sbjct: 692 LQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNS 744
Score = 39.3 bits (90), Expect = 0.004
Identities = 24/124 (19%), Positives = 59/124 (47%), Gaps = 4/124 (3%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNL---T 222
++ + +DL R+ ++ ME + + + + +++ + + + +L T
Sbjct: 529 LMQQKPQDLSRSF-INNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYT 587
Query: 223 SEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEE 282
++ +++++ ++QQQ+QQQQQQQQQQ QSS ++ ++ + ++
Sbjct: 588 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQ 647
Query: 283 DMLQ 286
Q
Sbjct: 648 QQQQ 651
Score = 30.0 bits (66), Expect = 2.7
Identities = 20/110 (18%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQ-----QQQQQQQGDL 253
Q Q + Q Q ++ ++++++ QQQ+QQQ QQQQQQQ
Sbjct: 589 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQ 648
Query: 254 SGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
Q ++ S ++ + +L++ + + + + ++ +
Sbjct: 649 QQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQ 698
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 44.7 bits (104), Expect = 1e-04
Identities = 40/181 (22%), Positives = 77/181 (42%), Gaps = 35/181 (19%)
Query: 123 LQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSR 182
LQ + +PKL + + L++ L++ + + + ++ LQ+ L +
Sbjct: 3876 LQQSLMSHSGQPKLSAQPMGSLQQ-------LQQQQQLQQQQQLQQQQQQQLQQQQQLQQ 3928
Query: 183 QEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ 242
Q++ + ++ L++ Q +Q + + Q Q ++ F++QQQ+QQ
Sbjct: 3929 QQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQ--------------QQQQFQQQQQQQQ 3974
Query: 243 -------------QQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAV 289
QQQQQQQ G + P + +S GALG L E++ + AV
Sbjct: 3975 MGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQH-FSSPGALGPTLLLTGKEQNTVDPAV 4033
Query: 290 T 290
+
Sbjct: 4034 S 4034
Score = 41.6 bits (96), Expect = 9e-04
Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
Q + QQ H+ + L+ L++ + + ++ GS + ++ LQ+ L +Q
Sbjct: 3856 QQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQ 3915
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ- 242
+ ++ L++ QL Q + + Q Q +L+++++ ++QQQ+QQ
Sbjct: 3916 QQQQLQQQQQLQQQ-QLQQQQQQQQLQQQQQQ---------QLQQQQQQLQQQQQQQQQQ 3965
Query: 243 -QQQQQQQQGDLSGQS 257
QQQQQQQQ L QS
Sbjct: 3966 FQQQQQQQQMGLLNQS 3981
Score = 35.4 bits (80), Expect = 0.064
Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 11/66 (16%)
Query: 188 EDEEADLRRAIQLSMQGSSRNISQDMT---QTSGTNLTSEELRKRREAYFEKQQQKQQQQ 244
E EAD + ++ Q S D Q TNL +E Y KQQQ+QQQQ
Sbjct: 3555 EFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAE--------YRNKQQQQQQQQ 3606
Query: 245 QQQQQQ 250
QQQQQQ
Sbjct: 3607 QQQQQQ 3612
Score = 31.6 bits (70), Expect = 0.92
Identities = 18/66 (27%), Positives = 34/66 (51%)
Query: 185 IDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQ 244
+ + ++ + Q SM G S M+ + L+++ + ++ ++Q Q+QQQ
Sbjct: 3853 VTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQL 3912
Query: 245 QQQQQQ 250
QQQQQQ
Sbjct: 3913 QQQQQQ 3918
Score = 30.4 bits (67), Expect = 2.0
Identities = 16/38 (42%), Positives = 22/38 (57%)
Query: 219 TNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQ 256
+ L E + ++ + Q+ QQQQQQQQQQ L GQ
Sbjct: 3713 SRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQ 3750
Score = 28.5 bits (62), Expect = 7.8
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 9/54 (16%)
Query: 207 RNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQ---------QQQQQQG 251
R++ D L ++ R + ++QQQ+QQQQ QQQQQQG
Sbjct: 3707 RSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQG 3760
Score = 28.5 bits (62), Expect = 7.8
Identities = 18/49 (36%), Positives = 28/49 (57%), Gaps = 1/49 (2%)
Query: 225 ELRKRREAYFEK-QQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALG 272
+L+++R +K QQQ+QQQQQQQ G ++ Q ++ ALG
Sbjct: 3722 QLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALG 3770
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 43.5 bits (101), Expect = 2e-04
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 6/82 (7%)
Query: 175 QRALALSRQEIDMEDEE------ADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRK 228
Q+ L SRQ ++++ E A +R +Q + ++ M L S R+
Sbjct: 1181 QQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQ 1240
Query: 229 RREAYFEKQQQKQQQQQQQQQQ 250
+R A +QQQ+QQQQQQQQQQ
Sbjct: 1241 QRVAMMMQQQQQQQQQQQQQQQ 1262
Score = 36.2 bits (82), Expect = 0.037
Identities = 18/52 (34%), Positives = 31/52 (59%)
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ 250
Q+ Q S +S Q + ++ +++++ ++QQQ+QQQQQQQQQQ
Sbjct: 1224 QMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 1275
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 42.4 bits (98), Expect = 5e-04
Identities = 54/216 (25%), Positives = 94/216 (43%), Gaps = 37/216 (17%)
Query: 78 LNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQ--MHRPK 135
LNS TGP L Q + + + L + + + L+ R+++ M R +
Sbjct: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
Query: 136 LIGEELAQ--LKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEA 192
L E L + L+ +R+ + LER + + L E +E L+R L RQE +D E +E
Sbjct: 171 LERERLERERLERERLEQEQLERERQERERQERL-ERQERLERQERLERQERLDRERQER 229
Query: 193 DLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGD 252
R + E L + R+ E+Q+Q +++Q + +++
Sbjct: 230 QERERL-------------------------ERLERERQER-ERQEQLEREQLEWERERR 263
Query: 253 LSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAA 288
+S ++ PA+ L S LGD+ + E LQAA
Sbjct: 264 ISSAAA-----PASVETPLNSVLGDSSASEPGLQAA 294
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 42.4 bits (98), Expect = 5e-04
Identities = 54/216 (25%), Positives = 94/216 (43%), Gaps = 37/216 (17%)
Query: 78 LNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQ--MHRPK 135
LNS TGP L Q + + + L + + + L+ R+++ M R +
Sbjct: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
Query: 136 LIGEELAQ--LKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEA 192
L E L + L+ +R+ + LER + + L E +E L+R L RQE +D E +E
Sbjct: 171 LERERLERERLERERLEQEQLERERQERERQERL-ERQERLERQERLERQERLDRERQER 229
Query: 193 DLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGD 252
R + E L + R+ E+Q+Q +++Q + +++
Sbjct: 230 QERERL-------------------------ERLERERQER-ERQEQLEREQLEWERERR 263
Query: 253 LSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAA 288
+S ++ PA+ L S LGD+ + E LQAA
Sbjct: 264 ISSAAA-----PASVETPLNSVLGDSSASEPGLQAA 294
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 42.4 bits (98), Expect = 5e-04
Identities = 38/151 (25%), Positives = 67/151 (44%), Gaps = 5/151 (3%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDE---EDL 174
E +Q Q +R +Q R K E Q +E+R + E+ E + +++E + L
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 175 QRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ--DMTQTSGTNLTSEELRKRREA 232
+R R+E + E+ + RR QL + R Q Q E + RRE
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 233 YFEKQQQKQQQQQQQQQQGDLSGQSSHPCER 263
++QQ +++QQ +++Q + + H ER
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQER 442
Score = 42.4 bits (98), Expect = 5e-04
Identities = 40/163 (24%), Positives = 69/163 (42%), Gaps = 15/163 (9%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
Q +R Q+ R E+L Q +E++ + + DG +E++ L+ RQ
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRP------QQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQ 243
E D + R Q + Q SR Q++ Q E RK RE + +QQ+++Q+
Sbjct: 1840 ERDRQ-----YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 244 QQQ----QQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEE 282
+Q + Q+G G+ P S S L + + E+
Sbjct: 1895 HRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQ 1937
Score = 40.8 bits (94), Expect = 0.002
Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 23/156 (14%)
Query: 101 QQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRP----KLIGEELAQLKEQRVHKTDLER 156
+QEG + D E +QLLQ QQ+HR K + EE +++R + +R
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665
Query: 157 VLEANDGSGMLDEDEEDLQRALALSRQEID--MEDEEADLRRAIQLSMQGSSRNISQDMT 214
+ + +L E EE L RQE D +EE LRR Q R Q+
Sbjct: 1666 DRKFREEEQLLQEGEEQ-----QLRRQERDRKFREEEQQLRR------QERERKFLQEEQ 1714
Query: 215 QTSGTNLTSEEL-RKRREAYFEKQQQKQQQQQQQQQ 249
Q L +EL RK RE +Q+ +Q+Q ++Q++
Sbjct: 1715 Q-----LRRQELERKFREEEQLRQETEQEQLRRQER 1745
Score = 40.0 bits (92), Expect = 0.003
Identities = 31/152 (20%), Positives = 65/152 (42%), Gaps = 6/152 (3%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
Q+++ ++ R + + E + EQR+ + ++ER+ + L +E + +R L +
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQ 243
E E + LRR Q + + ++ EE R+ +E E+Q+Q +++
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 244 ------QQQQQQQGDLSGQSSHPCERPATSSG 269
+ Q Q + + + S RP G
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Score = 39.3 bits (90), Expect = 0.004
Identities = 43/173 (24%), Positives = 77/173 (44%), Gaps = 26/173 (15%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVL 158
+L+QE +K + P+ E Q L Q+ R + + E + +EQR+ + + E L
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 159 EANDGSGMLDEDEEDLQRALALSRQEIDME-------------DEEADLRRAIQLSMQGS 205
E + +EE ++ LA QE E + EAD R++ S
Sbjct: 669 EQRLKR---EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 206 SRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQ--QQQQQQQQQGDLSGQ 256
+ Q EE R+RRE+ + Q++++ +QQQ+++Q+ D + Q
Sbjct: 726 QEGQRRRQEQ--------EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Score = 39.3 bits (90), Expect = 0.004
Identities = 37/137 (27%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query: 118 EADQLL----QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEED 173
E +QLL + R Q++ R EEL Q +EQ + + +R + + +EE+
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC---REEEE 1115
Query: 174 LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAY 233
LQ+ +E + EE + RR +L Q ++ Q L EE KRR
Sbjct: 1116 LQQ------EEEQLLREEREKRRRQELERQYRE----EEEVQQEEEQLLREEPEKRRRQE 1165
Query: 234 FEKQQQKQQQQQQQQQQ 250
E+Q +++++ QQ+++Q
Sbjct: 1166 LERQYREEEELQQEEEQ 1182
Score = 38.9 bits (89), Expect = 0.006
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 23/151 (15%)
Query: 118 EADQLLQMIRVQQMHRP---KLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDL 174
E +QLLQ QQ+HR + EE QL+ Q + E+ L + + E+E+ L
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 175 QRALA----------LSRQEIDM---EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNL 221
R L RQE +D + R QL + + +S+ Q
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR---QERDRKF 1581
Query: 222 TSEELRKRRE----AYFEKQQQKQQQQQQQQ 248
EE + RR+ + E +QQ ++Q+ QQQ
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Score = 37.7 bits (86), Expect = 0.013
Identities = 26/112 (23%), Positives = 51/112 (45%), Gaps = 4/112 (3%)
Query: 139 EELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAI 198
E+ Q +E+ + + E++L E E ++ L ++E + EE + RR
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR- 983
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ 250
+ + ++ Q L EE KRR +E+Q +K+ + QQ+++Q
Sbjct: 984 ---QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Score = 37.4 bits (85), Expect = 0.017
Identities = 33/134 (24%), Positives = 60/134 (44%), Gaps = 12/134 (8%)
Query: 129 QQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEE------DLQRALALSR 182
Q + +L EE L+E+R + ER + + + E+E+ + +R L R
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 183 Q---EIDMEDEEADLRRAIQLSMQGSSRNIS---QDMTQTSGTNLTSEELRKRREAYFEK 236
Q E +++ EE L R + R ++ Q L EE KRR E+
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 237 QQQKQQQQQQQQQQ 250
Q +++++ QQ+++Q
Sbjct: 1139 QYREEEEVQQEEEQ 1152
Score = 36.6 bits (83), Expect = 0.029
Identities = 25/111 (22%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 139 EELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAI 198
E + + +E+++ + + +R E L E+EE L++ L RQE+ E +E + ++
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRE-------LQEEEEQLRK---LERQELRRERQEEEQQQQR 299
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQ 249
Q R ++ + +E R+++E E+Q +++Q+++++QQ
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Score = 36.6 bits (83), Expect = 0.029
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 12/117 (10%)
Query: 145 KEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMED-------EEADLRRA 197
+E+ + + E L+ + + L E+E+ LQ R + D EE RR
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 198 IQL----SMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ 250
L ++Q R Q + Q L EE KRR E+Q ++++Q QQ+++Q
Sbjct: 887 HTLYAKPALQEQLRK-EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Score = 36.2 bits (82), Expect = 0.037
Identities = 26/127 (20%), Positives = 59/127 (46%), Gaps = 2/127 (1%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
+ ++ ++ R + + EE QL+ ++ + +L R + + E+ L+R R+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLR--KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQ 243
E E E RR Q + Q+ + EE R+ ++ E+++++++Q
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 244 QQQQQQQ 250
Q +++QQ
Sbjct: 376 QLRREQQ 382
Score = 35.8 bits (81), Expect = 0.049
Identities = 47/183 (25%), Positives = 73/183 (39%), Gaps = 22/183 (12%)
Query: 129 QQMHRP----KLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQE 184
QQ+HR K + EE +++R + +R + + + E EE LSRQE
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ-----QLSRQE 1576
Query: 185 IDMED--EEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ 242
D + EE +RR Q R +D Q ++LR+ R+ F + +Q Q
Sbjct: 1577 RDRKFRLEEQKVRR------QEQERKFMEDEQQLRRQE-GQQQLRQERDRKFREDEQLLQ 1629
Query: 243 QQQQQQ---QQGDLSGQSSHPCERPATSSGALGSDLGDAMSEED-MLQAAVTMSLETVRN 298
++++QQ Q+ D P R L D EE+ +LQ L
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 299 DLK 301
D K
Sbjct: 1690 DRK 1692
Score = 35.4 bits (80), Expect = 0.064
Identities = 25/137 (18%), Positives = 66/137 (48%), Gaps = 6/137 (4%)
Query: 114 LPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEED 173
L C+ + + +Q+ R EL +L+ + + +R E D +E++E
Sbjct: 193 LQSCKGHETEEFPDEEQLRR-----RELLELRRKGREEKQQQR-RERQDRVFQEEEEKEW 246
Query: 174 LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAY 233
+R L ++E +++EE +R +Q + + Q++ + ++ +R +
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 234 FEKQQQKQQQQQQQQQQ 250
KQ++++++QQ+++++
Sbjct: 307 RRKQEEERREQQEERRE 323
Score = 35.4 bits (80), Expect = 0.064
Identities = 28/135 (20%), Positives = 61/135 (45%), Gaps = 10/135 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRA 177
E ++ L+ + Q++ R + Q +EQ+ + E+ L ++ EE ++
Sbjct: 273 EEEEQLRKLERQELRRER-------QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 178 LALSRQEIDMEDE---EADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYF 234
+QE E + E + RR QL + Q + + ++LR+ ++
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 235 EKQQQKQQQQQQQQQ 249
E+Q +++QQ +++QQ
Sbjct: 386 EQQLRREQQLRREQQ 400
Score = 34.7 bits (78), Expect = 0.11
Identities = 29/124 (23%), Positives = 58/124 (46%), Gaps = 25/124 (20%)
Query: 127 RVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEID 186
R QQ R + + E + +EQR+ + E+EE LQ+ L S Q++
Sbjct: 497 REQQERREQQLRREQEERREQRLKR----------------QEEEERLQQRLR-SEQQLR 539
Query: 187 MEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQ 246
E EE R QL + + + Q+ + E +RR+ +++++++QQ+ +
Sbjct: 540 REQEE----RREQLLKREEEKRLEQERRE----QRLKREQEERRDQLLKREEERRQQRLK 591
Query: 247 QQQQ 250
++Q+
Sbjct: 592 REQE 595
Score = 33.5 bits (75), Expect = 0.24
Identities = 27/130 (20%), Positives = 56/130 (43%), Gaps = 3/130 (2%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
Q+ R QQ+ R + + E +EQ++ + R + + E E QR +
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELR---KRREAYFEKQQQK 240
D E + R Q + + ++ + L EE R +RRE ++Q++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 241 QQQQQQQQQQ 250
+++Q+ ++Q+
Sbjct: 514 RREQRLKRQE 523
Score = 33.5 bits (75), Expect = 0.24
Identities = 29/135 (21%), Positives = 62/135 (45%), Gaps = 13/135 (9%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD-----LERVLEANDGSGMLDEDEEDLQRAL 178
Q+ R QQ+ R + + E + + ++ H+ + L+R E + L +EE +
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR--EQEERRDWLKREEETERHEQ 469
Query: 179 ALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQ 238
+Q++ + EE RR L ++ R Q+ + E +RRE ++Q+
Sbjct: 470 ERRKQQLKRDQEEE--RRERWLKLEEEERREQQERREQQ----LRREQEERREQRLKRQE 523
Query: 239 QKQQQQQQQQQQGDL 253
++++ QQ+ + + L
Sbjct: 524 EEERLQQRLRSEQQL 538
Score = 32.3 bits (72), Expect = 0.54
Identities = 33/130 (25%), Positives = 57/130 (43%), Gaps = 21/130 (16%)
Query: 127 RVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEAN--DGSGMLDEDEEDLQRALALSRQE 184
R Q+ R + +L + +++R H + L+ +L E+EE+LQR R++
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE---EREK 920
Query: 185 IDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-- 242
+++E R QL Q L EE KRR E+Q +K +
Sbjct: 921 RRRQEQERQYREEEQL--------------QQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 243 QQQQQQQQGD 252
QQ+++Q G+
Sbjct: 967 QQKEEQLLGE 976
Score = 31.6 bits (70), Expect = 0.92
Identities = 36/136 (26%), Positives = 56/136 (41%), Gaps = 27/136 (19%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERV-LEANDGSGMLDEDEEDLQR 176
E +QL + + + R + EE L+E+R K + + + +L E EE
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ--- 1351
Query: 177 ALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKR---REAY 233
L RQE D + E +LR Q G EE R R RE
Sbjct: 1352 --PLRRQERDRKFREEELRH------------------QEQGRKFLEEEQRLRRQERERK 1391
Query: 234 FEKQQQKQQQQQQQQQ 249
F K++Q+ + Q+++QQ
Sbjct: 1392 FLKEEQQLRCQEREQQ 1407
Score = 31.6 bits (70), Expect = 0.92
Identities = 27/129 (20%), Positives = 54/129 (41%), Gaps = 19/129 (14%)
Query: 139 EELAQLKEQRVHKTDLERVLEANDGSGMLDEDE----EDLQRALALSRQEIDMEDEEADL 194
EE +++R K E + G L+E++ ++ +R Q++ ++ E L
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 195 RR---------AIQLSMQGSSRNISQDMTQTSGTNLT------SEELRKRREAYFEKQQQ 239
R+ QLS Q R ++ Q ++LR+ R F +++Q
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 240 KQQQQQQQQ 248
Q++++QQ
Sbjct: 1469 LLQEREEQQ 1477
Score = 30.8 bits (68), Expect = 1.6
Identities = 29/124 (23%), Positives = 57/124 (45%), Gaps = 17/124 (13%)
Query: 133 RPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEA 192
R + + EE Q + Q+ + + E L E EE ++ L +++ DEE
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERE-----------LAEGEEQSEKQERLEQRDRQRRDEE- 172
Query: 193 DLRRAIQLSMQGSSRNISQDMTQTSGTNLTSE----ELRKRREAYFEKQQQKQQQQQQQQ 248
L R Q + R ++ Q+ + T E E +RRE +++ ++++QQQ++
Sbjct: 173 -LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231
Query: 249 QQGD 252
++ D
Sbjct: 232 ERQD 235
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1912 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2024
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2025 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 257 S 257
+
Sbjct: 2083 A 2083
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2086
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2143
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2144 QEAARRAQAEQAALRQKQAAD 2164
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1344 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQ 1424
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1104 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQE 1251
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2595
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1916 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2028
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2029 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086
Query: 257 S 257
+
Sbjct: 2087 A 2087
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2090
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2147
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2148 QEAARRAQAEQAALRQKQAAD 2168
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1348 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQ 1428
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1108 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1166
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQE 1255
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2591
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1912 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2024
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2025 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 257 S 257
+
Sbjct: 2083 A 2083
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2086
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2143
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2144 QEAARRAQAEQAALRQKQAAD 2164
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1344 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQ 1424
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1104 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQE 1251
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2559
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1880 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 1992
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 1993 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050
Query: 257 S 257
+
Sbjct: 2051 A 2051
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2054
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2111
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2112 QEAARRAQAEQAALRQKQAAD 2132
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1312 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQ 1392
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1072 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1130
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1131 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1190
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQE 1219
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2728
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 2049 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2161
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2162 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219
Query: 257 S 257
+
Sbjct: 2220 A 2220
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2223
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2280
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2281 QEAARRAQAEQAALRQKQAAD 2301
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1481 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQ 1561
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1241 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1299
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1300 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1359
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQE 1388
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2569
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1890 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2002
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2003 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060
Query: 257 S 257
+
Sbjct: 2061 A 2061
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2064
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2121
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2122 QEAARRAQAEQAALRQKQAAD 2142
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1322 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQ 1402
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1082 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1140
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQE 1229
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2577
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1898 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2010
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2011 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068
Query: 257 S 257
+
Sbjct: 2069 A 2069
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2072
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2129
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2130 QEAARRAQAEQAALRQKQAAD 2150
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1330 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQ 1410
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1090 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1148
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1149 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1208
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQE 1237
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 42.4 bits (98), Expect = 5e-04
Identities = 37/150 (24%), Positives = 68/150 (45%), Gaps = 7/150 (4%)
Query: 116 DCEADQLLQMIRVQQMHRPKLIGE-ELAQLKEQRVHKTDLERVLEANDG--SGMLDEDEE 172
D +A++L + I + + KL E +L QLK + + E++L+ L E +
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 173 DLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRR-- 230
LQR + +++ +E D Q + R Q + + EE R+R+
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
Query: 231 --EAYFEKQQQKQQQQQQQQQQGDLSGQSS 258
E KQ++ QQ +QQ++QQ +L + +
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEEN 2618
Score = 31.2 bits (69), Expect = 1.2
Identities = 46/181 (25%), Positives = 75/181 (41%), Gaps = 19/181 (10%)
Query: 87 LISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQL---LQMIRVQQMHRPKLIGEELAQ 143
L+ DT L Q +Q I +K A + L++ R++ L +E A+
Sbjct: 1939 LVEDT-----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 144 LKEQRVHKTDLE-----RVLEANDGSGMLDEDEEDLQRALALSRQE-IDMEDEEADLRRA 197
L+ R + E R E + E+E QR AL E + + EEA RR
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA--RRL 2051
Query: 198 IQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ-QQQQQQQQGDLSGQ 256
+ + Q S+R + + Q + E + A +K+Q+ QQ QQ+Q L G+
Sbjct: 2052 RERAEQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109
Query: 257 S 257
+
Sbjct: 2110 A 2110
Score = 30.8 bits (68), Expect = 1.6
Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 11/141 (7%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDE--DEEDLQ 175
E + Q+ Q+ + +L EE A + + +L++ L+ +LD+ E +
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS--VLDQLRGEAEAA 2113
Query: 176 RALALSRQE--IDMEDEEADLRRAIQLS--MQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
R A +E + E E A RR ++ + ++ S+ +Q Q +E+LRK E
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA---AEKLRKEAE 2170
Query: 232 AYFEKQQQKQQQQQQQQQQGD 252
++ Q +Q +Q+Q D
Sbjct: 2171 QEAARRAQAEQAALRQKQAAD 2191
Score = 30.0 bits (66), Expect = 2.7
Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 167 LDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEEL 226
++E+E ++ A R+ + + EA L + QL+ + + EE+
Sbjct: 1371 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 227 RKRREAYFEKQQQKQQQQQQQQQ 249
+R EA + QQQK+ Q++ QQ
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQ 1451
Score = 28.5 bits (62), Expect = 7.8
Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 12/149 (8%)
Query: 166 MLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+L EE L+ A A+ ++E +A L++ ++ + + G E
Sbjct: 1131 VLRAHEEQLKEAQAVPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGER 1189
Query: 226 LRKRR-------EAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPAT----SSGALGSD 274
L++R E + E+ Q ++ Q Q D+ + R S+ LG+
Sbjct: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249
Query: 275 LGDAMSEEDMLQAAVTMSLETVRNDLKTE 303
L DA ++ +QA + VR L+ E
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQE 1278
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 42.0 bits (97), Expect = 7e-04
Identities = 47/185 (25%), Positives = 76/185 (41%), Gaps = 41/185 (22%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPK-----LIGEELAQLKEQRVHKTD 153
+LQQE S + EA + Q ++ QQ P+ L+ + +++EQ+ +
Sbjct: 357 RLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 154 LERVLEANDGSGMLDEDEED--LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ 211
+E L E E+ L+ AL R+E + E + QL Q S + +
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR 467
Query: 212 DMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ------GDLS-----GQSSHP 260
+ Q AY + QQ+QQQQQ Q+QQ GD G+ +P
Sbjct: 468 QLQQ--------------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNP 513
Query: 261 CERPA 265
++PA
Sbjct: 514 ADKPA 518
Score = 31.6 bits (70), Expect = 0.92
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)
Query: 169 EDEEDLQRALALSRQEIDME---DEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+D D R ++E + E EE D G S M + L E
Sbjct: 303 KDHIDRSRKKRGEKEETEYEYSGSEEED-------DSHGEEGEPSSIMNVPGESTLRREF 355
Query: 226 LRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSH 259
LR ++E + KQQQQ QQQQQ D H
Sbjct: 356 LRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 42.0 bits (97), Expect = 7e-04
Identities = 47/185 (25%), Positives = 76/185 (41%), Gaps = 41/185 (22%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPK-----LIGEELAQLKEQRVHKTD 153
+LQQE S + EA + Q ++ QQ P+ L+ + +++EQ+ +
Sbjct: 357 RLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 154 LERVLEANDGSGMLDEDEED--LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ 211
+E L E E+ L+ AL R+E + E + QL Q S + +
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR 467
Query: 212 DMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ------GDLS-----GQSSHP 260
+ Q AY + QQ+QQQQQ Q+QQ GD G+ +P
Sbjct: 468 QLQQ--------------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNP 513
Query: 261 CERPA 265
++PA
Sbjct: 514 ADKPA 518
Score = 31.6 bits (70), Expect = 0.92
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)
Query: 169 EDEEDLQRALALSRQEIDME---DEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+D D R ++E + E EE D G S M + L E
Sbjct: 303 KDHIDRSRKKRGEKEETEYEYSGSEEED-------DSHGEEGEPSSIMNVPGESTLRREF 355
Query: 226 LRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSH 259
LR ++E + KQQQQ QQQQQ D H
Sbjct: 356 LRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 42.0 bits (97), Expect = 7e-04
Identities = 47/185 (25%), Positives = 76/185 (41%), Gaps = 41/185 (22%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPK-----LIGEELAQLKEQRVHKTD 153
+LQQE S + EA + Q ++ QQ P+ L+ + +++EQ+ +
Sbjct: 357 RLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 154 LERVLEANDGSGMLDEDEED--LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ 211
+E L E E+ L+ AL R+E + E + QL Q S + +
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR 467
Query: 212 DMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ------GDLS-----GQSSHP 260
+ Q AY + QQ+QQQQQ Q+QQ GD G+ +P
Sbjct: 468 QLQQ--------------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNP 513
Query: 261 CERPA 265
++PA
Sbjct: 514 ADKPA 518
Score = 31.6 bits (70), Expect = 0.92
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)
Query: 169 EDEEDLQRALALSRQEIDME---DEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+D D R ++E + E EE D G S M + L E
Sbjct: 303 KDHIDRSRKKRGEKEETEYEYSGSEEED-------DSHGEEGEPSSIMNVPGESTLRREF 355
Query: 226 LRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSH 259
LR ++E + KQQQQ QQQQQ D H
Sbjct: 356 LRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 42.0 bits (97), Expect = 7e-04
Identities = 47/185 (25%), Positives = 76/185 (41%), Gaps = 41/185 (22%)
Query: 99 QLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPK-----LIGEELAQLKEQRVHKTD 153
+LQQE S + EA + Q ++ QQ P+ L+ + +++EQ+ +
Sbjct: 357 RLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRR 407
Query: 154 LERVLEANDGSGMLDEDEED--LQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ 211
+E L E E+ L+ AL R+E + E + QL Q S + +
Sbjct: 408 VEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR 467
Query: 212 DMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ------GDLS-----GQSSHP 260
+ Q AY + QQ+QQQQQ Q+QQ GD G+ +P
Sbjct: 468 QLQQ--------------EHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNP 513
Query: 261 CERPA 265
++PA
Sbjct: 514 ADKPA 518
Score = 31.6 bits (70), Expect = 0.92
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)
Query: 169 EDEEDLQRALALSRQEIDME---DEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEE 225
+D D R ++E + E EE D G S M + L E
Sbjct: 303 KDHIDRSRKKRGEKEETEYEYSGSEEED-------DSHGEEGEPSSIMNVPGESTLRREF 355
Query: 226 LRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSH 259
LR ++E + KQQQQ QQQQQ D H
Sbjct: 356 LRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKH 389
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 41.2 bits (95), Expect = 0.001
Identities = 38/147 (25%), Positives = 70/147 (47%), Gaps = 9/147 (6%)
Query: 121 QLLQMIRVQQMHRPKLIGEELAQLKEQ-RVHKTDLERVL-EANDGSGMLDEDEEDLQRAL 178
Q L++++ Q +L+ EE + + Q R + LE L EA + + E +
Sbjct: 362 QELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEA 421
Query: 179 ALSRQEI-DMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSE------ELRKRRE 231
A RQ I ++E+ + L+ A+QL ++ S + QT E +L++ +E
Sbjct: 422 ARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQE 481
Query: 232 AYFEKQQQKQQQQQQQQQQGDLSGQSS 258
Y E+ QQ++++ QQ+ Q S Q +
Sbjct: 482 RYIERAQQEKEELQQEMAQQSRSLQQA 508
Score = 35.0 bits (79), Expect = 0.083
Identities = 34/160 (21%), Positives = 68/160 (42%), Gaps = 13/160 (8%)
Query: 118 EADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRA 177
E + Q R++++ + +E QL+ + + R+ + +L+E+EE L++
Sbjct: 418 EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR----LLEEEEEKLKQL 473
Query: 178 LALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQ 237
+ L ++ + + +Q M SR++ Q Q + R+R + E
Sbjct: 474 MQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEV----RQNRQRADEDVEAA 529
Query: 238 QQKQQQQQQQQQQGDLS-GQSSHPCE----RPATSSGALG 272
Q+K +Q + ++ + HP E RP TSS G
Sbjct: 530 QRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSG 569
>gi|14149997 neuroblastoma breakpoint family, member 3 [Homo
sapiens]
Length = 633
Score = 40.8 bits (94), Expect = 0.002
Identities = 56/228 (24%), Positives = 94/228 (41%), Gaps = 51/228 (22%)
Query: 91 TYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVH 150
T +A FLA +Q Y D DC+ D + M+R +++ + + EEL Q +E R +
Sbjct: 101 TQVAYFLAN-RQNNY-------DYEDCK-DLIKSMLRDERLLTEEKLAEELGQAEELRQY 151
Query: 151 K----------TDL-ERVLEANDGS--------GMLDEDEEDLQRALALSRQEIDMEDEE 191
K T L E++ E D S +L DE D + Q D+ ++
Sbjct: 152 KVLVHSQERELTQLREKLQEGRDASRSLNQHLQALLTPDEPD-------NSQGRDLREQL 204
Query: 192 ADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQG 251
A+ R Q +Q +S + ++ EE K +E Y ++ QK ++++ +
Sbjct: 205 AEGCRLAQHLVQ----KLSPENDDDEDEDVKVEEAEKVQELYAPREVQKAEEKEVPEDSL 260
Query: 252 D----LSGQSSHPCE--------RPATSSGALGSDLGDAMSEEDMLQA 287
+ S HPCE R + S L D+ S ++ L A
Sbjct: 261 EECAITCSNSHHPCESNQPYGNTRITFEEDQVDSTLIDSSSHDEWLDA 308
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 39.7 bits (91), Expect = 0.003
Identities = 31/128 (24%), Positives = 54/128 (42%), Gaps = 17/128 (13%)
Query: 133 RPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEA 192
RP + +A + Q + ++++L+ S + Q+A+ L +Q++ ++
Sbjct: 83 RPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQ 142
Query: 193 DLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGD 252
+ +QL Q + Q Q ++QQQ+QQQQQQQQQQ
Sbjct: 143 QEQLHLQLLQQQQQQQQQQQQQQQQ-----------------QQQQQQQQQQQQQQQQQQ 185
Query: 253 LSGQSSHP 260
Q HP
Sbjct: 186 QQQQQQHP 193
Score = 38.1 bits (87), Expect = 0.010
Identities = 36/165 (21%), Positives = 70/165 (42%), Gaps = 4/165 (2%)
Query: 123 LQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSR 182
LQ + Q R L+ ++ + LK + +D +R L+ M+ Q+ + +
Sbjct: 52 LQQQQALQAARQLLLQQQTSGLKSPK--SSDKQRPLQVPVSVAMMTPQVITPQQMQQILQ 109
Query: 183 QEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQ 242
Q++ + L + Q M + Q+ + L + L+++++ ++QQQ+QQ
Sbjct: 110 QQVLSPQQLQALLQQQQAVMLQQQQ--LQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQ 167
Query: 243 QQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQA 287
QQQQQQQQ Q ++ G + ++ L A
Sbjct: 168 QQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAA 212
Score = 33.5 bits (75), Expect = 0.24
Identities = 37/169 (21%), Positives = 66/169 (39%), Gaps = 16/169 (9%)
Query: 140 ELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQ 199
EL L++Q+ + + +L+ SG+ D QR L + M + ++ Q
Sbjct: 48 ELLHLQQQQALQAARQLLLQQQT-SGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQ 106
Query: 200 LSMQG--SSRNISQDMTQTSGTNLTSEEL----RKRREAYF---------EKQQQKQQQQ 244
+ Q S + + + Q L ++L +K++E ++QQQ+QQQQ
Sbjct: 107 ILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQ 166
Query: 245 QQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSL 293
QQQQQQ Q ++ G + ++ Q L
Sbjct: 167 QQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQL 215
Score = 28.5 bits (62), Expect = 7.8
Identities = 29/159 (18%), Positives = 66/159 (41%), Gaps = 11/159 (6%)
Query: 115 PDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGS---GMLDEDE 171
P Q +Q I QQ+ P+ + L Q + + + L+ + +L + +
Sbjct: 96 PQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQ 155
Query: 172 EDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRRE 231
+ Q+ +Q+ + ++ ++ Q Q ++ + + ++L ++
Sbjct: 156 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQL 215
Query: 232 AYFEKQQQKQQQQQQ-----QQQQGDLS---GQSSHPCE 262
+ ++ Q QQ QQQ Q+QG +S GQ++ P +
Sbjct: 216 VFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQ 254
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 39.7 bits (91), Expect = 0.003
Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 171 EEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ--DMTQTSGTNLTSEELRK 228
EE+ +R L R+E ++ +L +A+Q Q + +S ++++ SGT + E+++
Sbjct: 947 EEERERQL---REE--QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1001
Query: 229 RREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGS 273
+Q QKQQQQQQQ QQ + + ++H + + GS
Sbjct: 1002 EEA----RQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGS 1042
Score = 35.0 bits (79), Expect = 0.083
Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 35/164 (21%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
+++R Q+ K EE E+ + + R+ + + + E+EE ++ L + RQ
Sbjct: 832 ELLRKQEEEAAKWAREE-----EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 886
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGT------------------------ 219
+ M + +L Q + ++Q +S T
Sbjct: 887 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 946
Query: 220 ------NLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQS 257
L E+ R++RE QQQ+QQQQQ+ G++S S
Sbjct: 947 EEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPS 990
Score = 33.9 bits (76), Expect = 0.19
Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 33/175 (18%)
Query: 127 RVQQMHRPKLIGEELAQLKEQRVHKTDLER--VLEANDGSGMLDEDEEDLQRALALSRQE 184
R Q+ R + EELA+ K++ + E+ L + EE L+R R+E
Sbjct: 765 RQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 824
Query: 185 IDMEDEEADLRRAIQLSM------QGSSRNISQD---MTQTSGTNLTSEELRKRREAYFE 235
+ +E LR+ + + + + R + ++ M + + EE RKR+E +
Sbjct: 825 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 884
Query: 236 KQQQ---------------KQQQQQQQQQQGDLS-----GQSSH--PCERPATSS 268
+Q++ +QQQQQQQ Q L GQ S+ C+ AT S
Sbjct: 885 RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS 939
Score = 33.1 bits (74), Expect = 0.32
Identities = 24/112 (21%), Positives = 52/112 (46%), Gaps = 17/112 (15%)
Query: 139 EELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAI 198
E+L QL++ + K + ER + +E+E Q L ++EI +E + +R
Sbjct: 718 EQLQQLEKAKAAKLEQER--REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ 250
+ + + E LR++RE ++Q++++++QQQ++
Sbjct: 776 EEELARRKQE---------------EALRRQREQEIALRRQREEEERQQQEE 812
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 39.7 bits (91), Expect = 0.003
Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 11/105 (10%)
Query: 171 EEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQ--DMTQTSGTNLTSEELRK 228
EE+ +R L R+E ++ +L +A+Q Q + +S ++++ SGT + E+++
Sbjct: 974 EEERERQL---REE--QRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQ 1028
Query: 229 RREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGS 273
+Q QKQQQQQQQ QQ + + ++H + + GS
Sbjct: 1029 EEA----RQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGS 1069
Score = 35.0 bits (79), Expect = 0.083
Identities = 35/164 (21%), Positives = 64/164 (39%), Gaps = 35/164 (21%)
Query: 124 QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQ 183
+++R Q+ K EE E+ + + R+ + + + E+EE ++ L + RQ
Sbjct: 859 ELLRKQEEEAAKWAREE-----EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 913
Query: 184 EIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGT------------------------ 219
+ M + +L Q + ++Q +S T
Sbjct: 914 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 973
Query: 220 ------NLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQS 257
L E+ R++RE QQQ+QQQQQ+ G++S S
Sbjct: 974 EEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPS 1017
Score = 33.9 bits (76), Expect = 0.19
Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 33/175 (18%)
Query: 127 RVQQMHRPKLIGEELAQLKEQRVHKTDLER--VLEANDGSGMLDEDEEDLQRALALSRQE 184
R Q+ R + EELA+ K++ + E+ L + EE L+R R+E
Sbjct: 792 RQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 851
Query: 185 IDMEDEEADLRRAIQLSM------QGSSRNISQD---MTQTSGTNLTSEELRKRREAYFE 235
+ +E LR+ + + + + R + ++ M + + EE RKR+E +
Sbjct: 852 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 911
Query: 236 KQQQ---------------KQQQQQQQQQQGDLS-----GQSSH--PCERPATSS 268
+Q++ +QQQQQQQ Q L GQ S+ C+ AT S
Sbjct: 912 RQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS 966
Score = 33.1 bits (74), Expect = 0.32
Identities = 24/112 (21%), Positives = 52/112 (46%), Gaps = 17/112 (15%)
Query: 139 EELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAI 198
E+L QL++ + K + ER + +E+E Q L ++EI +E + +R
Sbjct: 745 EQLQQLEKAKAAKLEQER--REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802
Query: 199 QLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQ 250
+ + + E LR++RE ++Q++++++QQQ++
Sbjct: 803 EEELARRKQE---------------EALRRQREQEIALRRQREEEERQQQEE 839
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,749,787
Number of Sequences: 37866
Number of extensions: 470034
Number of successful extensions: 7767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 319
Number of HSP's that attempted gapping in prelim test: 3636
Number of HSP's gapped (non-prelim): 1892
length of query: 306
length of database: 18,247,518
effective HSP length: 102
effective length of query: 204
effective length of database: 14,385,186
effective search space: 2934577944
effective search space used: 2934577944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.