Search of human proteins with 59889562

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|59889562 neurotrophic tyrosine kinase, receptor, type 3
isoform a precursor [Homo sapiens]
         (839 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...  1736   0.0  
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...  1692   0.0  
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo...  1096   0.0  
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   858   0.0  
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   848   0.0  
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   737   0.0  
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   736   0.0  
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   731   0.0  
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo...   363   e-100
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo...   352   6e-97
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo...   280   5e-75
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    265   1e-70
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...   239   1e-62
gi|62420886 discoidin domain receptor family, member 2 precursor...   238   1e-62
gi|62420884 discoidin domain receptor family, member 2 precursor...   238   1e-62
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...   237   3e-62
gi|38327632 discoidin domain receptor family, member 1 isoform b...   231   2e-60
gi|83977450 discoidin domain receptor family, member 1 isoform a...   231   2e-60
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   228   1e-59
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   228   1e-59
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   227   3e-59
gi|83977452 discoidin domain receptor family, member 1 isoform c...   226   9e-59
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   223   4e-58
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...   221   2e-57
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...   221   3e-57
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   219   1e-56
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...   216   7e-56
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   214   3e-55
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   213   5e-55
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   213   5e-55

>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score = 1736 bits (4495), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
           MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60

Query: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
           DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120

Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
           RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180

Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
           KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240

Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
           VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300

Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
           VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360

Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
           GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420

Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
           VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480

Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
           LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540

Query: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
           KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
Sbjct: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600

Query: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
           VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
Sbjct: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660

Query: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF 720
           SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
Sbjct: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF 720

Query: 721 CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 780
           CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
Sbjct: 721 CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 780

Query: 781 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
           ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Sbjct: 781 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score = 1692 bits (4381), Expect = 0.0
 Identities = 825/839 (98%), Positives = 825/839 (98%), Gaps = 14/839 (1%)

Query: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
           MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60

Query: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
           DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120

Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
           RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180

Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
           KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240

Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
           VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300

Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
           VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360

Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
           GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420

Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
           VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480

Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
           LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540

Query: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
           KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
Sbjct: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600

Query: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
           VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
Sbjct: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660

Query: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF 720
           SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR         
Sbjct: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR--------- 711

Query: 721 CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 780
                VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
Sbjct: 712 -----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 766

Query: 781 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
           ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Sbjct: 767 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825


>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
           c precursor [Homo sapiens]
          Length = 612

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 529/530 (99%), Positives = 530/530 (100%)

Query: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
           MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1   MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60

Query: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
           DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61  DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120

Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
           RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180

Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
           KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240

Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
           VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300

Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
           VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360

Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
           GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420

Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
           VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480

Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYV 530
           LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDT+V
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWV 530


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  858 bits (2218), Expect = 0.0
 Identities = 464/863 (53%), Positives = 573/863 (66%), Gaps = 80/863 (9%)

Query: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60

Query: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111

Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170

Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230

Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343

Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398

Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456

Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
            R SKFGMKGP +VIS ++DSASPLHHI++G  TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516

Query: 517 FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
           F   ++  KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL P +DK+LVAVK LKD
Sbjct: 517 FGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 576

Query: 577 PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
            +  ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYMKHGDLNKFLRAHGPDA
Sbjct: 577 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA 636

Query: 637 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
           +++ +G P     EL  SQMLHIA QIA+GMVYLASQHFVHRDLATRNCLVG NLLVKIG
Sbjct: 637 VLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 693

Query: 697 DFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSF 756
           DFGMSRDVYSTDYYR              VGGHTMLPIRWMPPESIMYRKFTTESDVWS 
Sbjct: 694 DFGMSRDVYSTDYYR--------------VGGHTMLPIRWMPPESIMYRKFTTESDVWSL 739

Query: 757 GVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLN 816
           GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP  R N
Sbjct: 740 GVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 799

Query: 817 IKEIYKILHALGKATPIYLDILG 839
           IK I+ +L  L KA+P+YLDILG
Sbjct: 800 IKGIHTLLQNLAKASPVYLDILG 822


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  848 bits (2191), Expect = 0.0
 Identities = 464/879 (52%), Positives = 573/879 (65%), Gaps = 96/879 (10%)

Query: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60

Query: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111

Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170

Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230

Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343

Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398

Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456

Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516

Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNL 560
           V+IGMT+IPVIENPQYF   ++  KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL 576

Query: 561 SPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYM 620
            P +DK+LVAVK LKD +  ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYM
Sbjct: 577 CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636

Query: 621 KHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680
           KHGDLNKFLRAHGPDA+++ +G P     EL  SQMLHIA QIA+GMVYLASQHFVHRDL
Sbjct: 637 KHGDLNKFLRAHGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDL 693

Query: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740
           ATRNCLVG NLLVKIGDFGMSRDVYSTDYYR              VGGHTMLPIRWMPPE
Sbjct: 694 ATRNCLVGENLLVKIGDFGMSRDVYSTDYYR--------------VGGHTMLPIRWMPPE 739

Query: 741 SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVY 800
           SIMYRKFTTESDVWS GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY
Sbjct: 740 SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVY 799

Query: 801 DVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
           ++MLGCWQREP  R NIK I+ +L  L KA+P+YLDILG
Sbjct: 800 ELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  737 bits (1903), Expect = 0.0
 Identities = 399/766 (52%), Positives = 503/766 (65%), Gaps = 43/766 (5%)

Query: 77  SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
           + N+T ++IEN + L  L   D+     L+ LTI  SGLR + P AF   P L  +NLS 
Sbjct: 65  AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124

Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
           N L +LSW+  Q LSL+EL L  N  +CSC +RW+Q W+E+G   +  Q L C      Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180

Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
            PL  M  + C +P + V   N +V  GD+ ++ C   G  L    WI+T L+      T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237

Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
            +    + ++ LTL NVTS+ N   +TC AEN VG +  SV + V +P  V      E+ 
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297

Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
              CI F V G P P+L WL NG  L E+  I  E+ +      +  GCL  N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356

Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
           GNYTL+A NP G A+ +I   F+  PF  + ++ I     +   P+    K +E  FGVS
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413

Query: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
           +AVGLA FAC+ L  L +++NK GRR+KFG+  P AV++ E+  A  LH +  G ++ S 
Sbjct: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472

Query: 494 LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF 553
            + G  + + G     +IENPQYF         D  V HIKRRDIVLK ELGEGAFGKVF
Sbjct: 473 TE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVF 519

Query: 554 LAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPL 613
           LAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL
Sbjct: 520 LAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPL 579

Query: 614 IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ 673
           +MVFEYM+HGDLN+FLR+HGPDA +L  G+   A G LGL Q+L +ASQ+A+GMVYLA  
Sbjct: 580 LMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGL 638

Query: 674 HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLP 733
           HFVHRDLATRNCLVG  L+VKIGDFGMSRD+YSTDYYR              VGG TMLP
Sbjct: 639 HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR--------------VGGRTMLP 684

Query: 734 IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR 793
           IRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR
Sbjct: 685 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 744

Query: 794 VCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
            CP EVY +M GCWQREPQQR +IK+++  L AL +A P+YLD+LG
Sbjct: 745 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  736 bits (1900), Expect = 0.0
 Identities = 402/780 (51%), Positives = 503/780 (64%), Gaps = 65/780 (8%)

Query: 77  SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
           + N+T ++IEN + L  L   D+     L+ LTI  SGLR + P AF   P L  +NLS 
Sbjct: 65  AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124

Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
           N L +LSW+  Q LSL+EL L  N  +CSC +RW+Q W+E+G   +  Q L C      Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180

Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
            PL  M  + C +P + V   N +V  GD+ ++ C   G  L    WI+T L+      T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237

Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
            +    + ++ LTL NVTS+ N   +TC AEN VG +  SV + V +P  V      E+ 
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297

Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
              CI F V G P P+L WL NG  L E+  I  E+ +      +  GCL  N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356

Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
           GNYTL+A NP G A+ +I   F+  PF           E +P  PI V+  P        
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405

Query: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
                 +E  FGVS+AVGLA FAC+ L  L +++NK GRR+KFG+  P AV++ E+  A 
Sbjct: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464

Query: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIV 539
            LH +  G ++ S  + G  + + G     +IENPQYF         D  V HIKRRDIV
Sbjct: 465 SLHFMTLGGSSLSPTE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIV 511

Query: 540 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 599
           LK ELGEGAFGKVFLAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+H
Sbjct: 512 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 571

Query: 600 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 659
           IV+F+GVC +G PL+MVFEYM+HGDLN+FLR+HGPDA +L  G+   A G LGL Q+L +
Sbjct: 572 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAV 630

Query: 660 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGND 719
           ASQ+A+GMVYLA  HFVHRDLATRNCLVG  L+VKIGDFGMSRD+YSTDYYR        
Sbjct: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR-------- 682

Query: 720 FCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV 779
                 VGG TMLPIRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE 
Sbjct: 683 ------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736

Query: 780 IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
           I+CITQGR LERPR CP EVY +M GCWQREPQQR +IK+++  L AL +A P+YLD+LG
Sbjct: 737 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  731 bits (1888), Expect = 0.0
 Identities = 397/763 (52%), Positives = 500/763 (65%), Gaps = 43/763 (5%)

Query: 80  ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
           + + +IEN + L  L   D+     L+ LTI  SGLR + P AF   P L  +NLS N L
Sbjct: 38  LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97

Query: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
            +LSW+  Q LSL+EL L  N  +CSC +RW+Q W+E+G   +  Q L C      Q PL
Sbjct: 98  ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153

Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
             M  + C +P + V   N +V  GD+ ++ C   G  L    WI+T L+      T + 
Sbjct: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210

Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
              + ++ LTL NVTS+ N   +TC AEN VG +  SV + V +P  V      E+    
Sbjct: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269

Query: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNNGNY 376
           CI F V G P P+L WL NG  L E+  I  E+ +      +  GCL  N+PTH NNGNY
Sbjct: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329

Query: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
           TL+A NP G A+ +I   F+  PF  + ++ I     +   P+    K +E  FGVS+AV
Sbjct: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386

Query: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
           GLA FAC+ L  L +++NK GRR+KFG+  P AV++ E+  A  LH +  G ++ S  + 
Sbjct: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444

Query: 497 GPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAE 556
           G  + + G     +IENPQYF         D  V HIKRRDIVLK ELGEGAFGKVFLAE
Sbjct: 445 GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVFLAE 492

Query: 557 CYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
           C+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL+MV
Sbjct: 493 CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMV 552

Query: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
           FEYM+HGDLN+FLR+HGPDA +L  G+   A G LGL Q+L +ASQ+A+GMVYLA  HFV
Sbjct: 553 FEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 611

Query: 677 HRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRW 736
           HRDLATRNCLVG  L+VKIGDFGMSRD+YSTDYYR              VGG TMLPIRW
Sbjct: 612 HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR--------------VGGRTMLPIRW 657

Query: 737 MPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCP 796
           MPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP
Sbjct: 658 MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACP 717

Query: 797 KEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
            EVY +M GCWQREPQQR +IK+++  L AL +A P+YLD+LG
Sbjct: 718 PEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760


>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
           e precursor [Homo sapiens]
          Length = 537

 Score =  363 bits (931), Expect = e-100
 Identities = 219/553 (39%), Positives = 308/553 (55%), Gaps = 63/553 (11%)

Query: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60

Query: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111

Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170

Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230

Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343

Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398

Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456

Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
            R SKFGMKGP +VIS ++DSASPLHHI++G  TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516

Query: 517 FRQGHNCHKPDTY 529
           F   ++  KPDT+
Sbjct: 517 FGITNSQLKPDTW 529


>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
           d precursor [Homo sapiens]
          Length = 553

 Score =  352 bits (904), Expect = 6e-97
 Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)

Query: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60

Query: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111

Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170

Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230

Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343

Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P         +P+    
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398

Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
                + D     +  +  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456

Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516

Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTY 529
           V+IGMT+IPVIENPQYF   ++  KPDT+
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545


>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
           b precursor [Homo sapiens]
          Length = 477

 Score =  280 bits (715), Expect = 5e-75
 Identities = 180/490 (36%), Positives = 257/490 (52%), Gaps = 63/490 (12%)

Query: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60

Query: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111

Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170

Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230

Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343

Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P         +P+    
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398

Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
                + D     +  +  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456

Query: 457 GRRSKFGMKG 466
            R SKFGMKG
Sbjct: 457 ARHSKFGMKG 466


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  265 bits (677), Expect = 1e-70
 Identities = 135/302 (44%), Positives = 191/302 (63%), Gaps = 23/302 (7%)

Query: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQREAELLT 593
           R +I   R++GEGAFG+VF A    L P +   +VAVK LK+   A  + DFQREA L+ 
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631

Query: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE--- 650
              + +IVK  GVC  G P+ ++FEYM +GDLN+FLR+  P  +  +       + +   
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691

Query: 651 -----LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 705
                L  ++ L IA Q+A+GM YL+ + FVHRDLATRNCLVG N++VKI DFG+SR++Y
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751

Query: 706 STDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 765
           S DYY+    + ND            +PIRWMPPESI Y ++TTESDVW++GV+LWEIF+
Sbjct: 752 SADYYKA---NEND-----------AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFS 797

Query: 766 YGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILH 825
           YG QP++ +++ EVI  +  G +L  P  CP E+Y++M  CW + P  R +   I++IL 
Sbjct: 798 YGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857

Query: 826 AL 827
            +
Sbjct: 858 RM 859



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 55/186 (29%), Positives = 81/186 (43%), Gaps = 27/186 (14%)

Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
           P+I+   +N+ + EG  AV+ C   G+P P V WI    +  +  + N     + + +L 
Sbjct: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWI----KGDSPLRENSRIAVLESGSLR 176

Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVA-LTVYYPPRVVSLEEPELRLEHCIEF----- 323
           + NV  ED G    C+A+N +G + + V  L V    R+  L  PE    H + F     
Sbjct: 177 IHNVQKEDAG-QYRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPE---SHNVTFGSFVT 230

Query: 324 ---VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLI 379
                 G P PT+ W+ NG  +    I   E  ++  I     LF  KP     G YT I
Sbjct: 231 LHCTATGIPVPTITWIENGNAVSSGSI--QESVKDRVIDSRLQLFITKP-----GLYTCI 283

Query: 380 AKNPLG 385
           A N  G
Sbjct: 284 ATNKHG 289



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 46/168 (27%), Positives = 69/168 (41%), Gaps = 20/168 (11%)

Query: 227 AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
           A   C     P P++ W    +  I    T  +      + LT+++V   D+G    C A
Sbjct: 45  ATFMCAVESYPQPEISWTRNKIL-IKLFDTRYSIRENGQL-LTILSVEDSDDGI-YCCTA 101

Query: 287 ENVVGMSNASV-ALTVYYPPRVVSLEEPELR------LEHCIEFVVRGNPPPTLHWLHNG 339
            N VG +  S  AL V   P++     P +       L+  +     GNP P++ W+   
Sbjct: 102 NNGVGGAVESCGALQVKMKPKIT---RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGD 158

Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
            PLRE+  I V       +  G L  +     + G Y  +AKN LGTA
Sbjct: 159 SPLRENSRIAV-------LESGSLRIHNVQKEDAGQYRCVAKNSLGTA 199


>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score =  239 bits (609), Expect = 1e-62
 Identities = 128/308 (41%), Positives = 176/308 (57%), Gaps = 16/308 (5%)

Query: 522 NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 581
           N HK    ++ I    +    ELGE  FGKV+    +  +P +    VA+K LKD     
Sbjct: 458 NQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP 516

Query: 582 -RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV 640
            R++F+ EA L   LQH ++V   GV     PL M+F Y  HGDL++FL    P + +  
Sbjct: 517 LREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS 576

Query: 641 DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGM 700
               R  K  L     +H+ +QIA+GM YL+S H VH+DLATRN LV   L VKI D G+
Sbjct: 577 TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636

Query: 701 SRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 760
            R+VY+ DYY+L               G+++LPIRWM PE+IMY KF+ +SD+WS+GV+L
Sbjct: 637 FREVYAADYYKLL--------------GNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVL 682

Query: 761 WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 820
           WE+F+YG QP+   SN +V+E I   +VL  P  CP  VY +M+ CW   P +R   K+I
Sbjct: 683 WEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742

Query: 821 YKILHALG 828
           +  L A G
Sbjct: 743 HSRLRAWG 750



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 1/88 (1%)

Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
           N+T+ +G  A++ C  +G+P P+V W+      +   +  +     +   L + ++ + D
Sbjct: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129

Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305
            G+   C+A N +    A+  L V   P
Sbjct: 130 TGY-YQCVATNGMKTITATGVLFVRLGP 156



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 23/88 (26%), Positives = 38/88 (43%), Gaps = 8/88 (9%)

Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQP-LRESKIIHVEYYQEGEISEGC 362
           P   +++ + +  + HC    V GNPPP + WL N  P ++E + I +   + G      
Sbjct: 67  PVNNITIVQGQTAILHC---KVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYG----SR 119

Query: 363 LLFNKPTHYNNGNYTLIAKNPLGTANQT 390
           L        + G Y  +A N + T   T
Sbjct: 120 LRIQDLDTTDTGYYQCVATNGMKTITAT 147


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  238 bits (608), Expect = 1e-62
 Identities = 139/318 (43%), Positives = 189/318 (59%), Gaps = 40/318 (12%)

Query: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575
           D  V+   R+ +  K +LGEG FG+V L E   +   KDK           +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611

Query: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634
            D    AR DF +E ++++ L+  +I+    VC   DPL M+ EYM++GDLN+FL  H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671

Query: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694
                 D +       +  + +  +A+QIASGM YL+S +FVHRDLATRNCLVG N  +K
Sbjct: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725

Query: 695 IGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVW 754
           I DFGMSR++YS DYYR              + G  +LPIRWM  ESI+  KFTT SDVW
Sbjct: 726 IADFGMSRNLYSGDYYR--------------IQGRAVLPIRWMSWESILLGKFTTASDVW 771

Query: 755 SFGVILWEIFTY-GKQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGC 806
           +FGV LWE FT+  +QP+ QLS+ +VIE        QGR   L +P +CP  VY +ML C
Sbjct: 772 AFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSC 831

Query: 807 WQREPQQRLNIKEIYKIL 824
           W+R+ + R + +EI+ +L
Sbjct: 832 WRRDTKNRPSFQEIHLLL 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  238 bits (608), Expect = 1e-62
 Identities = 139/318 (43%), Positives = 189/318 (59%), Gaps = 40/318 (12%)

Query: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575
           D  V+   R+ +  K +LGEG FG+V L E   +   KDK           +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611

Query: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634
            D    AR DF +E ++++ L+  +I+    VC   DPL M+ EYM++GDLN+FL  H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671

Query: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694
                 D +       +  + +  +A+QIASGM YL+S +FVHRDLATRNCLVG N  +K
Sbjct: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725

Query: 695 IGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVW 754
           I DFGMSR++YS DYYR              + G  +LPIRWM  ESI+  KFTT SDVW
Sbjct: 726 IADFGMSRNLYSGDYYR--------------IQGRAVLPIRWMSWESILLGKFTTASDVW 771

Query: 755 SFGVILWEIFTY-GKQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGC 806
           +FGV LWE FT+  +QP+ QLS+ +VIE        QGR   L +P +CP  VY +ML C
Sbjct: 772 AFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSC 831

Query: 807 WQREPQQRLNIKEIYKIL 824
           W+R+ + R + +EI+ +L
Sbjct: 832 WRRDTKNRPSFQEIHLLL 849


>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score =  237 bits (605), Expect = 3e-62
 Identities = 130/321 (40%), Positives = 183/321 (57%), Gaps = 23/321 (7%)

Query: 509 PVIENPQYFRQGH------NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSP 562
           PV   P++ R  +      N +KP +  + +    +    ELGE AFGK++    Y L  
Sbjct: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPG 496

Query: 563 TKDKMLVAVKALKDPTLAAR-KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMK 621
                LVA+K LKD     +  +FQ+EA L+  L H +IV   G      P+ M+FEY+ 
Sbjct: 497 MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYIN 556

Query: 622 HGDLNKFLRAHGPDAMI-LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680
            GDL++FL    P + +     +    K  L     LHIA QIA+GM YL+S  FVH+DL
Sbjct: 557 QGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDL 616

Query: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740
           A RN L+G  L VKI D G+SR++YS DYYR+ + S              +LPIRWMPPE
Sbjct: 617 AARNILIGEQLHVKISDLGLSREIYSADYYRVQSKS--------------LLPIRWMPPE 662

Query: 741 SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVY 800
           +IMY KF+++SD+WSFGV+LWEIF++G QP++  SN EVIE + + ++L     CP  +Y
Sbjct: 663 AIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMY 722

Query: 801 DVMLGCWQREPQQRLNIKEIY 821
            +M  CW   P +R   K+I+
Sbjct: 723 SLMTECWNEIPSRRPRFKDIH 743



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 1/88 (1%)

Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
           N+T   G  A + C  SG+P P + W       +   +     + ++   L + N+ + D
Sbjct: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125

Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305
            G+   C+A N   + +++  L V + P
Sbjct: 126 TGY-FQCVATNGKEVVSSTGVLFVKFGP 152



 Score = 31.2 bits (69), Expect = 4.2
 Identities = 17/55 (30%), Positives = 24/55 (43%), Gaps = 3/55 (5%)

Query: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPL 342
           N+    N    LT+  P   ++    +    HC    V GNPPPT+ W  N  P+
Sbjct: 47  NISSELNKDSYLTLDEPMNNITTSLGQTAELHC---KVSGNPPPTIRWFKNDAPV 98


>gi|38327632 discoidin domain receptor family, member 1 isoform b
           [Homo sapiens]
          Length = 876

 Score =  231 bits (589), Expect = 2e-60
 Identities = 138/314 (43%), Positives = 188/314 (59%), Gaps = 39/314 (12%)

Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
           R  +  K +LGEG FG+V L E           + L+  K   +LVAVK L+ D T  AR
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629

Query: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
            DF +E ++++ L+  +I++  GVC   DPL M+ +YM++GDLN+FL AH  +       
Sbjct: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689

Query: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
             DGQ  Q    +    +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N  +KI DF
Sbjct: 690 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 748

Query: 699 GMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGV 758
           GMSR++Y+ DYYR              V G  +LPIRWM  E I+  KFTT SDVW+FGV
Sbjct: 749 GMSRNLYAGDYYR--------------VQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 794

Query: 759 ILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQRE 810
            LWE+    + QP+ QL++ +VIE        QGR   L RP  CP+ +Y++ML CW RE
Sbjct: 795 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 854

Query: 811 PQQRLNIKEIYKIL 824
            +QR    ++++ L
Sbjct: 855 SEQRPPFSQLHRFL 868


>gi|83977450 discoidin domain receptor family, member 1 isoform a
           [Homo sapiens]
          Length = 913

 Score =  231 bits (589), Expect = 2e-60
 Identities = 138/314 (43%), Positives = 188/314 (59%), Gaps = 39/314 (12%)

Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
           R  +  K +LGEG FG+V L E           + L+  K   +LVAVK L+ D T  AR
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 666

Query: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
            DF +E ++++ L+  +I++  GVC   DPL M+ +YM++GDLN+FL AH  +       
Sbjct: 667 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 726

Query: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
             DGQ  Q    +    +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N  +KI DF
Sbjct: 727 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 785

Query: 699 GMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGV 758
           GMSR++Y+ DYYR              V G  +LPIRWM  E I+  KFTT SDVW+FGV
Sbjct: 786 GMSRNLYAGDYYR--------------VQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 831

Query: 759 ILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQRE 810
            LWE+    + QP+ QL++ +VIE        QGR   L RP  CP+ +Y++ML CW RE
Sbjct: 832 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 891

Query: 811 PQQRLNIKEIYKIL 824
            +QR    ++++ L
Sbjct: 892 SEQRPPFSQLHRFL 905


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  228 bits (582), Expect = 1e-59
 Identities = 124/317 (39%), Positives = 180/317 (56%), Gaps = 27/317 (8%)

Query: 513  NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568
            NP+Y         + + PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041

Query: 569  VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
            VAVK + +  +L  R +F  EA ++      H+V+  GV   G P ++V E M HGDL  
Sbjct: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101

Query: 628  FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
            +LR+  P+A      +    +    L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 1102 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1155

Query: 688  GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKF 747
              +  VKIGDFGM+RD+Y TDYYR               GG  +LP+RWM PES+    F
Sbjct: 1156 AHDFTVKIGDFGMTRDIYETDYYRK--------------GGKGLLPVRWMAPESLKDGVF 1201

Query: 748  TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 807
            TT SD+WSFGV+LWEI +  +QP+  LSN +V++ +  G  L++P  CP+ V D+M  CW
Sbjct: 1202 TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCW 1261

Query: 808  QREPQQRLNIKEIYKIL 824
            Q  P+ R    EI  +L
Sbjct: 1262 QFNPKMRPTFLEIVNLL 1278


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  228 bits (582), Expect = 1e-59
 Identities = 124/317 (39%), Positives = 180/317 (56%), Gaps = 27/317 (8%)

Query: 513  NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568
            NP+Y         + + PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 996  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1053

Query: 569  VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
            VAVK + +  +L  R +F  EA ++      H+V+  GV   G P ++V E M HGDL  
Sbjct: 1054 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1113

Query: 628  FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
            +LR+  P+A      +    +    L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 1114 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1167

Query: 688  GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKF 747
              +  VKIGDFGM+RD+Y TDYYR               GG  +LP+RWM PES+    F
Sbjct: 1168 AHDFTVKIGDFGMTRDIYETDYYRK--------------GGKGLLPVRWMAPESLKDGVF 1213

Query: 748  TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 807
            TT SD+WSFGV+LWEI +  +QP+  LSN +V++ +  G  L++P  CP+ V D+M  CW
Sbjct: 1214 TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCW 1273

Query: 808  QREPQQRLNIKEIYKIL 824
            Q  P+ R    EI  +L
Sbjct: 1274 QFNPKMRPTFLEIVNLL 1290


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  227 bits (579), Expect = 3e-59
 Identities = 121/309 (39%), Positives = 179/309 (57%), Gaps = 24/309 (7%)

Query: 513  NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
            NP+YF    + + PD +   + R  I + RELG+G+FG V+      +   + +  VA+K
Sbjct: 977  NPEYFSAA-DVYVPDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033

Query: 573  ALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRA 631
             + +  ++  R +F  EA ++      H+V+  GV   G P +++ E M  GDL  +LR+
Sbjct: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093

Query: 632  HGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL 691
              P+    ++  P  A   L  S+M+ +A +IA GM YL +  FVHRDLA RNC+V  + 
Sbjct: 1094 LRPE----MENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147

Query: 692  LVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTES 751
             VKIGDFGM+RD+Y TDYYR               GG  +LP+RWM PES+    FTT S
Sbjct: 1148 TVKIGDFGMTRDIYETDYYRK--------------GGKGLLPVRWMSPESLKDGVFTTYS 1193

Query: 752  DVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREP 811
            DVWSFGV+LWEI T  +QP+  LSN +V+  + +G +L++P  CP  ++++M  CWQ  P
Sbjct: 1194 DVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNP 1253

Query: 812  QQRLNIKEI 820
            + R +  EI
Sbjct: 1254 KMRPSFLEI 1262


>gi|83977452 discoidin domain receptor family, member 1 isoform c
           [Homo sapiens]
          Length = 919

 Score =  226 bits (575), Expect = 9e-59
 Identities = 136/320 (42%), Positives = 188/320 (58%), Gaps = 45/320 (14%)

Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALKDP------ 577
           R  +  K +LGEG FG+V L E           + L+  K   +LVAVK L+        
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAS 666

Query: 578 -TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
            +L +R DF +E ++++ L+  +I++  GVC   DPL M+ +YM++GDLN+FL AH  + 
Sbjct: 667 FSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 726

Query: 637 MILV----DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL 692
                   DGQ  Q    +    +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N  
Sbjct: 727 KAAEGAPGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 785

Query: 693 VKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESD 752
           +KI DFGMSR++Y+ DYYR              V G  +LPIRWM  E I+  KFTT SD
Sbjct: 786 IKIADFGMSRNLYAGDYYR--------------VQGRAVLPIRWMAWECILMGKFTTASD 831

Query: 753 VWSFGVILWEIFTYGK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVML 804
           VW+FGV LWE+    + QP+ QL++ +VIE        QGR   L RP  CP+ +Y++ML
Sbjct: 832 VWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELML 891

Query: 805 GCWQREPQQRLNIKEIYKIL 824
            CW RE +QR    ++++ L
Sbjct: 892 RCWSRESEQRPPFSQLHRFL 911


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  223 bits (569), Expect = 4e-58
 Identities = 127/311 (40%), Positives = 179/311 (57%), Gaps = 28/311 (9%)

Query: 513  NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
            NP+YF    + + PD +   + R  I + RELG+G+FG V+      L   ++   VA+K
Sbjct: 957  NPEYF-SASDMYVPDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013

Query: 573  ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
             + +  LA+ ++   F +EA ++   +  H+V+  GV   G P +++ E M  GDL   L
Sbjct: 1014 TVNE--LASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHL 1071

Query: 630  RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689
            R+  P+A     G P+ A GE     M+ +A +IA GM YLA+  FVHRDLA RNC+V  
Sbjct: 1072 RSLRPEAENN-PGLPQPALGE-----MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ 1125

Query: 690  NLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTT 749
            +  VKIGDFGM+RDVY TDYYR               GG  +LP+RWM PES+    FTT
Sbjct: 1126 DFTVKIGDFGMTRDVYETDYYRK--------------GGKGLLPVRWMAPESLKDGIFTT 1171

Query: 750  ESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQR 809
             SDVWSFGV+LWEI T  +QP+  LSN +V++ +  G VLE    CP ++ ++M  CWQ 
Sbjct: 1172 HSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQP 1231

Query: 810  EPQQRLNIKEI 820
             P+ R +   I
Sbjct: 1232 NPRLRPSFTHI 1242


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score =  221 bits (564), Expect = 2e-57
 Identities = 176/616 (28%), Positives = 279/616 (45%), Gaps = 81/616 (13%)

Query: 227  AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
            A + C+ +G   P + W      S+        W   +A  L    VT +D G   TCIA
Sbjct: 520  ATVPCSATGREKPTIKWERADGSSLP------EWVTDNAGTLHFARVTRDDAG-NYTCIA 572

Query: 287  EN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339
             N   G   A V LTV         P   ++ +    L  C     +G+P P + W    
Sbjct: 573  SNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPKPLIQWKGKD 629

Query: 340  QPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFL 396
            + L  +K+   +H+          G L+ +     ++G YT IA N     +     + +
Sbjct: 630  RILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682

Query: 397  KEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKY 456
             +P PE ++        SP P   +       T G+S+    AA A ++ V+  +   K 
Sbjct: 683  DKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAVLGLMFYCKK 728

Query: 457  GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
              ++K   K P     GEE     L+        PS+ +   +  +  +   P   N ++
Sbjct: 729  RCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH 783

Query: 517  FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
                   H P + +Q I          LG+  FG+VFLA+   L     + LV VK+L+ 
Sbjct: 784  -STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQS 834

Query: 577  PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
                 + DF+RE E+   L H ++V+  G+C + +P  MV EY+  GDL +FLR      
Sbjct: 835  KDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR------ 888

Query: 637  MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
             I      +     L   Q + + +Q+A GM +L++  FVH+DLA RNCLV A   VK+ 
Sbjct: 889  -ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 947

Query: 697  DFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSF 756
              G+S+DVY+++YY                     +P+RWM PE+I+   F+T+SDVW+F
Sbjct: 948  ALGLSKDVYNSEYYHF---------------RQAWVPLRWMSPEAILEGDFSTKSDVWAF 992

Query: 757  GVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRL 815
            GV++WE+FT+G+ P    ++ EV+  +  G+  L +P  CP ++Y +M  CW   P+ R 
Sbjct: 993  GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRP 1052

Query: 816  NIKEIYKILHALGKAT 831
            +  E   I  ALG +T
Sbjct: 1053 SFSE---IASALGDST 1065



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)

Query: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389

Query: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446

Query: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
            N   + E     V          G L  N    Y+   Y  ++  P G+
Sbjct: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 567 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 625

Query: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 626 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 681

Query: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
              P     E P             G+PPP
Sbjct: 682 VDKPVPEESEGP-------------GSPPP 698



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274

Query: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334

Query: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382

Query: 370 HYNNGNYTLIAKNPLGTANQTIN 392
             + G YT  A N  G   Q +N
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVN 405



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99

Query: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159

Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
           [Homo sapiens]
          Length = 940

 Score =  221 bits (562), Expect = 3e-57
 Identities = 181/625 (28%), Positives = 283/625 (45%), Gaps = 84/625 (13%)

Query: 221 VREGDNAVITC---NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
           + E D  V TC   N +G    DV+  V    S+        W   +A  L    VT +D
Sbjct: 381 IAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP------EWVTDNAGTLHFARVTRDD 434

Query: 278 NGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPP 330
            G   TCIA N   G   A V LTV         P   ++ +    L  C     +G+P 
Sbjct: 435 AG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPK 490

Query: 331 PTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
           P + W    + L  +K+   +H+          G L+ +     ++G YT IA N     
Sbjct: 491 PLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIK 543

Query: 388 NQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLV 447
           +     + + +P PE ++        SP P   +       T G+S+    AA A ++ V
Sbjct: 544 HTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAV 589

Query: 448 VLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTR 507
           +  +   K   ++K   K P     GEE     L+        PS+ +   +  +  +  
Sbjct: 590 LGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGS 644

Query: 508 IPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM 567
            P   N ++       H P + +Q I          LG+  FG+VFLA+   L     + 
Sbjct: 645 GPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAET 695

Query: 568 LVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
           LV VK+L+      + DF+RE E+   L H ++V+  G+C + +P  MV EY+  GDL +
Sbjct: 696 LVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 755

Query: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
           FLR       I      +     L   Q + + +Q+A GM +L++  FVH+DLA RNCLV
Sbjct: 756 FLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLV 808

Query: 688 GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKF 747
            A   VK+   G+S+DVY+++YY                     +P+RWM PE+I+   F
Sbjct: 809 SAQRQVKVSALGLSKDVYNSEYYHF---------------RQAWVPLRWMSPEAILEGDF 853

Query: 748 TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGC 806
           +T+SDVW+FGV++WE+FT+G+ P    ++ EV+  +  G+  L +P  CP ++Y +M  C
Sbjct: 854 STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRC 913

Query: 807 WQREPQQRLNIKEIYKILHALGKAT 831
           W   P+ R +  E   I  ALG +T
Sbjct: 914 WALSPKDRPSFSE---IASALGDST 935



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 495

Query: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 496 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 551

Query: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
              P     E P             G+PPP
Sbjct: 552 VDKPVPEESEGP-------------GSPPP 568



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274

Query: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334

Query: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382

Query: 370 HYNNGNYTLIAKNPLGTANQTIN 392
             + G YT  A N  G   Q +N
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVN 405



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99

Query: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159

Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  219 bits (557), Expect = 1e-56
 Identities = 149/528 (28%), Positives = 248/528 (46%), Gaps = 67/528 (12%)

Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
           GNP PT+ WL NG+  ++   I     +    S   L+       + GNYT + +N  G+
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWS---LIMESVVPSDKGNYTCVVENEYGS 239

Query: 387 ANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLL 446
            N T +                  D V+P     +T  P+     +   +G+   AC+++
Sbjct: 240 INHTYH-----------------LDVVAPGREKEITASPDYLEIAI-YCIGVFLIACMVV 281

Query: 447 VVLFVMINKYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDA 496
            V+   +    ++  F  +  V            ++   +S+S ++     +   + L +
Sbjct: 282 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 341

Query: 497 GPDTVVI-GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA 555
             DT ++ G++   + E+P++                  R  + L + LGEG FG+V +A
Sbjct: 342 TADTPMLAGVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMA 386

Query: 556 ECYNLSPTKDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGD 611
           E   +   K K  + VAVK LKD  T     D   E E++  + +H++I+   G C    
Sbjct: 387 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 446

Query: 612 PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA 671
           PL ++ EY   G+L ++LRA  P  M       R  + ++    ++    Q+A GM YLA
Sbjct: 447 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 506

Query: 672 SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTM 731
           SQ  +HRDLA RN LV  N ++KI DFG++RD+ + DYY+                 +  
Sbjct: 507 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT--------------NGR 552

Query: 732 LPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLER 791
           LP++WM PE++  R +T +SDVWSFGV++WEIFT G  P+  +   E+ + + +G  +++
Sbjct: 553 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 612

Query: 792 PRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT--PIYLDI 837
           P  C  E+Y +M  CW   P QR   K++ + L  +   T    YLD+
Sbjct: 613 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 1/76 (1%)

Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
           C   G+P+P + W+  G +    H+           +L + +V   D G   TC+ EN  
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237

Query: 291 GMSNASVALTVYYPPR 306
           G  N +  L V  P R
Sbjct: 238 GSINHTYHLDVVAPGR 253


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score =  216 bits (550), Expect = 7e-56
 Identities = 170/583 (29%), Positives = 268/583 (45%), Gaps = 75/583 (12%)

Query: 260  WTNVHAINLTLVNVTSEDNGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEE 312
            W   +A  L    VT +D G   TCIA N   G   A V LTV         P   ++ +
Sbjct: 507  WVTDNAGTLHFARVTRDDAG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ 565

Query: 313  PELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPT 369
                L  C     +G+P P + W    + L  +K+   +H+          G L+ +   
Sbjct: 566  GHTALLQC---EAQGDPKPLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVA 615

Query: 370  HYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDT 429
              ++G YT IA N     +     + + +P PE ++        SP P   +       T
Sbjct: 616  PEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QT 664

Query: 430  FGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGIT 489
             G+S+    AA A ++ V+  +   K   ++K   K P     GEE     L+       
Sbjct: 665  IGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNG 717

Query: 490  TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAF 549
             PS+ +   +  +  +   P   N ++       H P + +Q I          LG+  F
Sbjct: 718  QPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEF 767

Query: 550  GKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609
            G+VFLA+   L     + LV VK+L+      + DF+RE E+   L H ++V+  G+C +
Sbjct: 768  GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE 827

Query: 610  GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY 669
             +P  MV EY+  GDL +FLR       I      +     L   Q + + +Q+A GM +
Sbjct: 828  AEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880

Query: 670  LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGH 729
            L++  FVH+DLA RNCLV A   VK+   G+S+DVY+++YY                   
Sbjct: 881  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF---------------RQ 925

Query: 730  TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV- 788
              +P+RWM PE+I+   F+T+SDVW+FGV++WE+FT+G+ P    ++ EV+  +  G+  
Sbjct: 926  AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985

Query: 789  LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 831
            L +P  CP ++Y +M  CW   P+ R +  E   I  ALG +T
Sbjct: 986  LPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGDST 1025



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 48/187 (25%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389

Query: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446

Query: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTAN-----QTI 391
            N   + E     V          G L  N    Y+   Y  ++  P G+       Q +
Sbjct: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499

Query: 392 NGHFLKE 398
           +G  L E
Sbjct: 500 DGSSLPE 506



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 527 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 585

Query: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 586 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 641

Query: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
              P     E P             G+PPP
Sbjct: 642 VDKPVPEESEGP-------------GSPPP 658



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274

Query: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334

Query: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382

Query: 370 HYNNGNYTLIAKNPLGTANQTIN 392
             + G YT  A N  G   Q +N
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVN 405



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99

Query: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159

Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  214 bits (544), Expect = 3e-55
 Identities = 170/640 (26%), Positives = 285/640 (44%), Gaps = 78/640 (12%)

Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
           C   G+P+P + W+  G +    H+           +L + +V   D G   TC+ EN  
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237

Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
           G  N +  L V        + +  L           +EFV  V  +  P + W+     N
Sbjct: 238 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 297

Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
           G       + +++  +   I+    E   LFN  T  + G Y     N +G ANQ     
Sbjct: 298 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 351

Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
                   S    +L  + +P     +T  P+     +   +G+   AC+++ V+   + 
Sbjct: 352 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 402

Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
              ++  F  +  V            ++   +S+S ++     +   + L +  DT ++ 
Sbjct: 403 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 462

Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
           G++   + E+P++                  R  + L + LGEG FG+V +AE   +   
Sbjct: 463 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507

Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
           K K  + VAVK LKD  T     D   E E++  + +H++I+   G C    PL ++ EY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567

Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
              G+L ++LRA  P  M       R  + ++    ++    Q+A GM YLASQ  +HRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627

Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPP 739
           LA RN LV  N ++KI DFG++RD+ + DYY+                 +  LP++WM P
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTT--------------NGRLPVKWMAP 673

Query: 740 ESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEV 799
           E++  R +T +SDVWSFGV++WEIFT G  P+  +   E+ + + +G  +++P  C  E+
Sbjct: 674 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 733

Query: 800 YDVMLGCWQREPQQRLNIKEIYKILHALGKAT--PIYLDI 837
           Y +M  CW   P QR   K++ + L  +   T    YLD+
Sbjct: 734 YMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 773


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  213 bits (543), Expect = 5e-55
 Identities = 166/625 (26%), Positives = 279/625 (44%), Gaps = 76/625 (12%)

Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
           C   G+P+P + W+  G +    H+           +L + +V   D G   TC+ EN  
Sbjct: 90  CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 148

Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
           G  N +  L V        + +  L           +EFV  V  +  P + W+     N
Sbjct: 149 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208

Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
           G       + +++  +   I+    E   LFN  T  + G Y     N +G ANQ     
Sbjct: 209 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 262

Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
                   S    +L  + +P     +T  P+     +   +G+   AC+++ V+   + 
Sbjct: 263 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 313

Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
              ++  F  +  V            ++   +S+S ++     +   + L +  DT ++ 
Sbjct: 314 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 373

Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
           G++   + E+P++                  R  + L + LGEG FG+V +AE   +   
Sbjct: 374 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418

Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
           K K  + VAVK LKD  T     D   E E++  + +H++I+   G C    PL ++ EY
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478

Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
              G+L ++LRA  P  M       R  + ++    ++    Q+A GM YLASQ  +HRD
Sbjct: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538

Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPP 739
           LA RN LV  N ++KI DFG++RD+ + DYY+                 +  LP++WM P
Sbjct: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTT--------------NGRLPVKWMAP 584

Query: 740 ESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEV 799
           E++  R +T +SDVWSFGV++WEIFT G  P+  +   E+ + + +G  +++P  C  E+
Sbjct: 585 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 644

Query: 800 YDVMLGCWQREPQQRLNIKEIYKIL 824
           Y +M  CW   P QR   K++ + L
Sbjct: 645 YMMMRDCWHAVPSQRPTFKQLVEDL 669


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  213 bits (543), Expect = 5e-55
 Identities = 166/625 (26%), Positives = 279/625 (44%), Gaps = 76/625 (12%)

Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
           C   G+P+P + W+  G +    H+           +L + +V   D G   TC+ EN  
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237

Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
           G  N +  L V        + +  L           +EFV  V  +  P + W+     N
Sbjct: 238 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 297

Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
           G       + +++  +   I+    E   LFN  T  + G Y     N +G ANQ     
Sbjct: 298 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 351

Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
                   S    +L  + +P     +T  P+     +   +G+   AC+++ V+   + 
Sbjct: 352 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 402

Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
              ++  F  +  V            ++   +S+S ++     +   + L +  DT ++ 
Sbjct: 403 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 462

Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
           G++   + E+P++                  R  + L + LGEG FG+V +AE   +   
Sbjct: 463 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507

Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
           K K  + VAVK LKD  T     D   E E++  + +H++I+   G C    PL ++ EY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567

Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
              G+L ++LRA  P  M       R  + ++    ++    Q+A GM YLASQ  +HRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627

Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPP 739
           LA RN LV  N ++KI DFG++RD+ + DYY+                 +  LP++WM P
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTT--------------NGRLPVKWMAP 673

Query: 740 ESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEV 799
           E++  R +T +SDVWSFGV++WEIFT G  P+  +   E+ + + +G  +++P  C  E+
Sbjct: 674 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNEL 733

Query: 800 YDVMLGCWQREPQQRLNIKEIYKIL 824
           Y +M  CW   P QR   K++ + L
Sbjct: 734 YMMMRDCWHAVPSQRPTFKQLVEDL 758


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,906,135
Number of Sequences: 37866
Number of extensions: 1649262
Number of successful extensions: 8022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 721
Number of HSP's successfully gapped in prelim test: 376
Number of HSP's that attempted gapping in prelim test: 3363
Number of HSP's gapped (non-prelim): 2867
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.