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Search of human proteins with 59850762
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59850762 uveal autoantigen with coiled-coil domains and
ankyrin repeats isoform 1 [Homo sapiens]
(1416 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 2736 0.0
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 2689 0.0
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 355 2e-97
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 355 2e-97
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 355 2e-97
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 355 2e-97
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 351 2e-96
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 351 3e-96
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 261 3e-69
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 193 1e-48
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 182 2e-45
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 181 3e-45
gi|71061468 centromere protein E [Homo sapiens] 178 3e-44
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 177 6e-44
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 176 1e-43
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 174 7e-43
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 172 3e-42
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 172 3e-42
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 171 4e-42
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 171 4e-42
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 171 4e-42
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 170 1e-41
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 166 1e-40
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 166 1e-40
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 160 6e-39
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 160 6e-39
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 160 6e-39
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 160 6e-39
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 159 1e-38
gi|156104908 myosin heavy chain 6 [Homo sapiens] 157 5e-38
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 2736 bits (7092), Expect = 0.0
Identities = 1416/1416 (100%), Positives = 1416/1416 (100%)
Query: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN
Sbjct: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
Query: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL
Sbjct: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
Query: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP
Sbjct: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
Query: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA
Sbjct: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
Query: 241 RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE 300
RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE
Sbjct: 241 RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE 300
Query: 301 IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHE 360
IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHE
Sbjct: 301 IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHE 360
Query: 361 ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR
Sbjct: 361 ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
Query: 421 SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALE 480
SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALE
Sbjct: 421 SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALE 480
Query: 481 CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE
Sbjct: 481 CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE 540
Query: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM
Sbjct: 541 ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
Query: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS 660
EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS
Sbjct: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS 660
Query: 661 LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE
Sbjct: 661 LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 720
Query: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 780
KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL
Sbjct: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 780
Query: 781 EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 840
EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK
Sbjct: 781 EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 840
Query: 841 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI 900
IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI
Sbjct: 841 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI 900
Query: 901 KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI
Sbjct: 901 KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
Query: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE
Sbjct: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
Query: 1021 EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYT 1080
EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYT
Sbjct: 1021 EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYT 1080
Query: 1081 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1140
EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR
Sbjct: 1081 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1140
Query: 1141 CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE
Sbjct: 1141 CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
Query: 1201 VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE 1260
VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE
Sbjct: 1201 VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE 1260
Query: 1261 VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK 1320
VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK
Sbjct: 1261 VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK 1320
Query: 1321 ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV
Sbjct: 1321 ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
Query: 1381 IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC 1416
IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC
Sbjct: 1381 IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC 1416
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 2689 bits (6969), Expect = 0.0
Identities = 1390/1390 (100%), Positives = 1390/1390 (100%)
Query: 27 HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA 86
HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA
Sbjct: 14 HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA 73
Query: 87 ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 146
ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC
Sbjct: 74 ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 133
Query: 147 PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 206
PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML
Sbjct: 134 PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 193
Query: 207 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW 266
GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW
Sbjct: 194 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW 253
Query: 267 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326
KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG
Sbjct: 254 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
Query: 327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386
LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH
Sbjct: 314 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
Query: 387 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446
FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL
Sbjct: 374 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
Query: 447 EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM 506
EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM
Sbjct: 434 EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM 493
Query: 507 YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ 566
YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ
Sbjct: 494 YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ 553
Query: 567 IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 626
IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS
Sbjct: 554 IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 613
Query: 627 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 686
IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE
Sbjct: 614 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 673
Query: 687 HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 746
HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP
Sbjct: 674 HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 733
Query: 747 LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP 806
LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP
Sbjct: 734 LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP 793
Query: 807 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 866
EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE
Sbjct: 794 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 853
Query: 867 EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 926
EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA
Sbjct: 854 EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 913
Query: 927 EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA 986
EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA
Sbjct: 914 EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA 973
Query: 987 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1046
PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD
Sbjct: 974 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1033
Query: 1047 KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1106
KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL
Sbjct: 1034 KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1093
Query: 1107 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166
LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL
Sbjct: 1094 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153
Query: 1167 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1226
AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL
Sbjct: 1154 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1213
Query: 1227 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1286
SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI
Sbjct: 1214 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1273
Query: 1287 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG
Sbjct: 1274 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1406
NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ
Sbjct: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1393
Query: 1407 IIQMRQGLVC 1416
IIQMRQGLVC
Sbjct: 1394 IIQMRQGLVC 1403
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 355 bits (911), Expect = 2e-97
Identities = 303/1104 (27%), Positives = 528/1104 (47%), Gaps = 170/1104 (15%)
Query: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
Query: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
Query: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
Query: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
Query: 241 RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE 300
++ +N I +LL + ++ +L K P+ + + L+ + ++ S + + +
Sbjct: 226 KLSENAGIQSLLLS---KISQDADL--KTPT-KPKQLSDVSSPRSITSTPLSGK--ESVF 277
Query: 301 IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ-- 358
K + I++ + L D G + ++ E++++ L SLL AK
Sbjct: 278 FAEPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLT 331
Query: 359 -HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPA 415
H + L+ K+ K E+D L S+ S + + L K G+ DS+ +SP +
Sbjct: 332 LHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLI 388
Query: 416 HMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAE 473
H SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE
Sbjct: 389 H------------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE 436
Query: 474 CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 533
+ L + E+S + L LK+ Q + E+ +V +Q +K L S +
Sbjct: 437 --LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESM 487
Query: 534 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK 593
N+ EL+ +++ V K+D +EE+
Sbjct: 488 DNYSHFHELRVTEEEINV-------------------------LKQDLQNALEES----- 517
Query: 594 ELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
E+ KV E+E + E + P E++E MKSS + + K+ +
Sbjct: 518 ---------ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFL 568
Query: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
+++++ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ +
Sbjct: 569 FEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYK 624
Query: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 773
Q E+E Y K L++ +T E Y+ K H+ ++ N
Sbjct: 625 EAQAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAED 668
Query: 774 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 833
+E K + K+L E L + V + V +H + I L++ E+++++S LK+
Sbjct: 669 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 728
Query: 834 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 893
+ ++ L + K M++ VP ++E+++ +L ++ +L + K+ E +
Sbjct: 729 LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKV 788
Query: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY 953
+ E V+I+ + +KR EN Q +K+ K Q+ N E+L +
Sbjct: 789 HSEVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKF 827
Query: 954 RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLS 1010
++ QEE+ AE+K + ++ E+ ++K KE LK+ L+
Sbjct: 828 QQAQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALN 870
Query: 1011 EQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRK 1064
+Q S S K+ Q+ + L++++ LQ L + + + + + H + +
Sbjct: 871 SLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQM 929
Query: 1065 TDELNKQLKDLSQKYTEVKNVKEK 1088
+++ K LK Q T KN +K
Sbjct: 930 DEDVQKVLK---QILTMCKNQSQK 950
Score = 228 bits (582), Expect = 2e-59
Identities = 176/660 (26%), Positives = 329/660 (49%), Gaps = 64/660 (9%)
Query: 763 DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEII--ALKSNI 820
+L KL + K E L + L + + P K ++ +L +
Sbjct: 336 ELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKST 395
Query: 821 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 880
+ ++ +L++ + Q+++ + +E L+ V +++ + LN+T
Sbjct: 396 TDNDVRIQQLQEILQDLQKRLESSEAERKQLQ-------VELQSRRAELVCLNNT----- 443
Query: 881 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE-------HEAKMS 933
++ + D++Q+ + + K E + + + Q Q+K +S HE +++
Sbjct: 444 ----EISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 499
Query: 934 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE 993
++ K NA L + +E++ L E K ++E T+ + P+ +EE
Sbjct: 500 EEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTVIK------PPVEEYEE 549
Query: 994 CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1053
+ + + + + + + +KY ++EE+ K K D LK ++ D +
Sbjct: 550 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEASD---------E 597
Query: 1054 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1113
+ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++ E + + + + +H
Sbjct: 598 AEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654
Query: 1114 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1173
L Q+ + ++ ++ L M+ Y K +T+L QL++ QK +SV + EHLQ+
Sbjct: 655 LMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVI 708
Query: 1174 EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK 1233
++ + +E +K EV+KL+ ++ K A+ T +V S Y+ +
Sbjct: 709 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM----TDAMVPRSSYEKLQ 764
Query: 1234 SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF---SIEQEIKDQK 1290
S LE+++S L KL ++ E+V EV+ + + K EKE + S EQE+ +
Sbjct: 765 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 824
Query: 1291 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1350
++ ++ + E++R + S+K E KD KI E+ +V +LK+ALN LSQL+Y++ + +K
Sbjct: 825 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS-SK 883
Query: 1351 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1410
RQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG MDEDVQ+ L QI+ M
Sbjct: 884 RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 355 bits (911), Expect = 2e-97
Identities = 304/1127 (26%), Positives = 527/1127 (46%), Gaps = 187/1127 (16%)
Query: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
Query: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
Query: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
Query: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
Query: 241 RIGDNLDILTLL-----------------------KTASENTNKGRELWKKGPSLQQRNL 277
++ +N I +LL K +SE + ++ P + L
Sbjct: 226 KLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQL 285
Query: 278 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
+ + ++ S + + + K + I++ + L D G + ++
Sbjct: 286 SDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLL 337
Query: 338 ADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE-- 392
E++++ L SLL AK H + L+ K+ K E+D L S+ S + +
Sbjct: 338 DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLG 395
Query: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMR 450
L K G+ DS+ +SP + H SL T+ ++ I L++ L+ ++
Sbjct: 396 PSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQ 442
Query: 451 TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESE 510
ES++ +R +LQ EL + AE + L + E+S + L LK+ Q + E+
Sbjct: 443 KRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAM 496
Query: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
+V +Q +K L S + N+ EL+ +++ V
Sbjct: 497 KEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV------------------- 534
Query: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
K+D +EE+ E+ KV E+E + E + P E
Sbjct: 535 ------LKQDLQNALEES--------------ERNKEKVRELEEKLVEREKGTVIKPPVE 574
Query: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
++E MKSS + + K+ + +++++ EI +LK + +K+++ Q +E E +
Sbjct: 575 EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDM 630
Query: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
K + + EL K+++EL+ + Q E+E Y K L++ +T E Y+
Sbjct: 631 KEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE----YI----- 676
Query: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
K H+ ++ N +E K + K+L E L + V + V +H
Sbjct: 677 --HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 734
Query: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 870
+ I L++ E+++++S LK+ + ++ L + K M++ VP ++E+++
Sbjct: 735 QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQS 794
Query: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 930
+L ++ +L + K+ E ++ E V+I+ + +KR EN Q +K+
Sbjct: 795 SLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS---------- 844
Query: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
K Q+ N E+L +++ QEE+ AE+K + ++
Sbjct: 845 ----------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE------------ 877
Query: 991 FEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD- 1046
E+ ++K KE LK+ L+ +Q S S K+ Q+ + L++++ LQ L +
Sbjct: 878 -EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
Query: 1047 -----KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
+ + + + H + + +++ K LK Q T KN +K
Sbjct: 936 KKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 979
Score = 232 bits (591), Expect = 2e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 223 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282
Query: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
L + + + I L K E K ++ ++D D L
Sbjct: 283 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336
Query: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 337 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392
Query: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452
Query: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 453 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512
Query: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 513 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 569 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 620 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 668 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 722 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779
Query: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 780 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837
Query: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 838 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897
Query: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 898 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956
Query: 1395 HMDEDVQEALLQIIQM 1410
MDEDVQ+ L QI+ M
Sbjct: 957 QMDEDVQKVLKQILTM 972
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 355 bits (911), Expect = 2e-97
Identities = 304/1127 (26%), Positives = 527/1127 (46%), Gaps = 187/1127 (16%)
Query: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
Query: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
Query: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
Query: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
Query: 241 RIGDNLDILTLL-----------------------KTASENTNKGRELWKKGPSLQQRNL 277
++ +N I +LL K +SE + ++ P + L
Sbjct: 226 KLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQL 285
Query: 278 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
+ + ++ S + + + K + I++ + L D G + ++
Sbjct: 286 SDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLL 337
Query: 338 ADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE-- 392
E++++ L SLL AK H + L+ K+ K E+D L S+ S + +
Sbjct: 338 DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLG 395
Query: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMR 450
L K G+ DS+ +SP + H SL T+ ++ I L++ L+ ++
Sbjct: 396 PSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQ 442
Query: 451 TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESE 510
ES++ +R +LQ EL + AE + L + E+S + L LK+ Q + E+
Sbjct: 443 KRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAM 496
Query: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
+V +Q +K L S + N+ EL+ +++ V
Sbjct: 497 KEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV------------------- 534
Query: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
K+D +EE+ E+ KV E+E + E + P E
Sbjct: 535 ------LKQDLQNALEES--------------ERNKEKVRELEEKLVEREKGTVIKPPVE 574
Query: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
++E MKSS + + K+ + +++++ EI +LK + +K+++ Q +E E +
Sbjct: 575 EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDM 630
Query: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
K + + EL K+++EL+ + Q E+E Y K L++ +T E Y+
Sbjct: 631 KEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE----YI----- 676
Query: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
K H+ ++ N +E K + K+L E L + V + V +H
Sbjct: 677 --HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 734
Query: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 870
+ I L++ E+++++S LK+ + ++ L + K M++ VP ++E+++
Sbjct: 735 QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQS 794
Query: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 930
+L ++ +L + K+ E ++ E V+I+ + +KR EN Q +K+
Sbjct: 795 SLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS---------- 844
Query: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
K Q+ N E+L +++ QEE+ AE+K + ++
Sbjct: 845 ----------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE------------ 877
Query: 991 FEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD- 1046
E+ ++K KE LK+ L+ +Q S S K+ Q+ + L++++ LQ L +
Sbjct: 878 -EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
Query: 1047 -----KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
+ + + + H + + +++ K LK Q T KN +K
Sbjct: 936 KKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 979
Score = 232 bits (591), Expect = 2e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 223 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282
Query: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
L + + + I L K E K ++ ++D D L
Sbjct: 283 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336
Query: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 337 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392
Query: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452
Query: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 453 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512
Query: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 513 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 569 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 620 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 668 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 722 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779
Query: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 780 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837
Query: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 838 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897
Query: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 898 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956
Query: 1395 HMDEDVQEALLQIIQM 1410
MDEDVQ+ L QI+ M
Sbjct: 957 QMDEDVQKVLKQILTM 972
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 355 bits (911), Expect = 2e-97
Identities = 304/1127 (26%), Positives = 527/1127 (46%), Gaps = 187/1127 (16%)
Query: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
Query: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
Query: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
Query: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
Query: 241 RIGDNLDILTLL-----------------------KTASENTNKGRELWKKGPSLQQRNL 277
++ +N I +LL K +SE + ++ P + L
Sbjct: 226 KLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQL 285
Query: 278 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
+ + ++ S + + + K + I++ + L D G + ++
Sbjct: 286 SDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLL 337
Query: 338 ADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE-- 392
E++++ L SLL AK H + L+ K+ K E+D L S+ S + +
Sbjct: 338 DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLG 395
Query: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMR 450
L K G+ DS+ +SP + H SL T+ ++ I L++ L+ ++
Sbjct: 396 PSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQ 442
Query: 451 TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESE 510
ES++ +R +LQ EL + AE + L + E+S + L LK+ Q + E+
Sbjct: 443 KRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAM 496
Query: 511 GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQN 570
+V +Q +K L S + N+ EL+ +++ V
Sbjct: 497 KEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV------------------- 534
Query: 571 EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAE 630
K+D +EE+ E+ KV E+E + E + P E
Sbjct: 535 ------LKQDLQNALEES--------------ERNKEKVRELEEKLVEREKGTVIKPPVE 574
Query: 631 KFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
++E MKSS + + K+ + +++++ EI +LK + +K+++ Q +E E +
Sbjct: 575 EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDM 630
Query: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
K + + EL K+++EL+ + Q E+E Y K L++ +T E Y+
Sbjct: 631 KEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE----YI----- 676
Query: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE 810
K H+ ++ N +E K + K+L E L + V + V +H
Sbjct: 677 --HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL 734
Query: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 870
+ I L++ E+++++S LK+ + ++ L + K M++ VP ++E+++
Sbjct: 735 QVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQS 794
Query: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 930
+L ++ +L + K+ E ++ E V+I+ + +KR EN Q +K+
Sbjct: 795 SLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS---------- 844
Query: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
K Q+ N E+L +++ QEE+ AE+K + ++
Sbjct: 845 ----------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE------------ 877
Query: 991 FEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD- 1046
E+ ++K KE LK+ L+ +Q S S K+ Q+ + L++++ LQ L +
Sbjct: 878 -EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAEC 935
Query: 1047 -----KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
+ + + + H + + +++ K LK Q T KN +K
Sbjct: 936 KKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 979
Score = 232 bits (591), Expect = 2e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 223 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282
Query: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
L + + + I L K E K ++ ++D D L
Sbjct: 283 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336
Query: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 337 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392
Query: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 393 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452
Query: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 453 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512
Query: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 513 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 569 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 620 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 668 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 722 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779
Query: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 780 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837
Query: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 838 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897
Query: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 898 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956
Query: 1395 HMDEDVQEALLQIIQM 1410
MDEDVQ+ L QI+ M
Sbjct: 957 QMDEDVQKVLKQILTM 972
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 351 bits (901), Expect = 2e-96
Identities = 298/1102 (27%), Positives = 518/1102 (47%), Gaps = 172/1102 (15%)
Query: 26 AHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLN 85
A +WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL
Sbjct: 3 AKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 62
Query: 86 AILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMAD 145
++ HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA
Sbjct: 63 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
Query: 146 CPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM 205
C ++Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALM
Sbjct: 123 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 182
Query: 206 LGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL------------- 252
L CE G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 183 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 242
Query: 253 ----------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIE 302
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 243 TKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFA 300
Query: 303 NEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---H 359
K + I++ + L D G + ++ E++++ L SLL AK H
Sbjct: 301 EPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLH 354
Query: 360 EESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHM 417
+ L+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 355 NKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH- 410
Query: 418 QSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECK 475
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE
Sbjct: 411 -----------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-- 457
Query: 476 ALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGN 535
+ L + E+S + L LK+ Q + E+ +V +Q +K L S + N
Sbjct: 458 LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDN 510
Query: 536 HRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKEL 595
+ EL+ +++ V K+D +EE+
Sbjct: 511 YSHFHELRVTEEEINV-------------------------LKQDLQNALEES------- 538
Query: 596 SMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
E+ KV E+E + E + P E++E MKSS + + K+ +
Sbjct: 539 -------ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE 591
Query: 656 EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTL 715
+++++ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ +
Sbjct: 592 KYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEA 647
Query: 716 QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Q E+E Y K L++ +T E Y+ K H+ ++ N
Sbjct: 648 QAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDAL 691
Query: 776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 835
+E K + K+L E L + V + V +H + I L++ E+++++S LK+
Sbjct: 692 SEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLA 751
Query: 836 EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 895
+ ++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++
Sbjct: 752 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 811
Query: 896 EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 955
E V+I+ + +KR EN Q +K+ K Q+ N E+L +++
Sbjct: 812 EVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQ 850
Query: 956 GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQ 1012
QEE+ AE+K + ++ E+ ++K KE LK+ L+
Sbjct: 851 AQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSL 893
Query: 1013 TQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTD 1066
+Q S S K+ Q+ + L++++ LQ L + + + + + H + + +
Sbjct: 894 SQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 952
Query: 1067 ELNKQLKDLSQKYTEVKNVKEK 1088
++ K LK Q T KN +K
Sbjct: 953 DVQKVLK---QILTMCKNQSQK 971
Score = 232 bits (591), Expect = 2e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 215 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 274
Query: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
L + + + I L K E K ++ ++D D L
Sbjct: 275 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 328
Query: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 329 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 384
Query: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 385 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 444
Query: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 445 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 504
Query: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 505 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 560
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 561 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 611
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 612 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 659
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 660 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 713
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 714 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 771
Query: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 772 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 829
Query: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 830 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 889
Query: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 890 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 948
Query: 1395 HMDEDVQEALLQIIQM 1410
MDEDVQ+ L QI+ M
Sbjct: 949 QMDEDVQKVLKQILTM 964
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 351 bits (900), Expect = 3e-96
Identities = 297/1098 (27%), Positives = 517/1098 (47%), Gaps = 172/1098 (15%)
Query: 30 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 89
+WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL ++
Sbjct: 18 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 77
Query: 90 HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 149
HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA C +
Sbjct: 78 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 137
Query: 150 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 209
+Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALML CE
Sbjct: 138 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 197
Query: 210 YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 252
G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL
Sbjct: 198 IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 257
Query: 253 ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 306
K +SE + ++ P + L+ + ++ S + + +
Sbjct: 258 QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 315
Query: 307 KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 363
K + I++ + L D G + ++ E++++ L SLL AK H + L
Sbjct: 316 KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 369
Query: 364 RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 421
+ K+ K E+D L S+ S + + L K G+ DS+ +SP + H
Sbjct: 370 QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 421
Query: 422 MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 479
SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE + L
Sbjct: 422 -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 472
Query: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
+ E+S + L LK+ Q + E+ +V +Q +K L S + N+
Sbjct: 473 NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 525
Query: 540 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
EL+ +++ V K+D +EE+
Sbjct: 526 HELRVTEEEINV-------------------------LKQDLQNALEES----------- 549
Query: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 659
E+ KV E+E + E + P E++E MKSS + + K+ + ++++
Sbjct: 550 ---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
Query: 660 SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 719
+ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ + Q E+
Sbjct: 607 AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 662
Query: 720 EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 779
E Y K L++ +T E Y+ K H+ ++ N +E K
Sbjct: 663 ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 706
Query: 780 LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 839
+ K+L E L + V + V +H + I L++ E+++++S LK+ +
Sbjct: 707 SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 766
Query: 840 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 899
++ L + K M++ VP ++E+++ +L ++ +L + K+ E ++ E V+
Sbjct: 767 EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 826
Query: 900 IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 959
I+ + +KR EN Q +K+ K Q+ N E+L +++ QEE
Sbjct: 827 IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 865
Query: 960 IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1016
+ AE+K + ++ E+ ++K KE LK+ L+ +Q
Sbjct: 866 L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 907
Query: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1070
S S K+ Q+ + L++++ LQ L + + + + + H + + +++ K
Sbjct: 908 SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 967
Query: 1071 QLKDLSQKYTEVKNVKEK 1088
LK Q T KN +K
Sbjct: 968 VLK---QILTMCKNQSQK 982
Score = 232 bits (591), Expect = 2e-60
Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)
Query: 657 HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 707
H LSE I+ L + A L KP++H+QV ++SG K+ I+
Sbjct: 226 HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 285
Query: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
L + + + I L K E K ++ ++D D L
Sbjct: 286 TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 339
Query: 768 LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
LD++ + ++ L ++ L L N L +L+ + + + S
Sbjct: 340 -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 395
Query: 822 ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 869
+L L + + D + IH+L T+ L++++ + +++ E +
Sbjct: 396 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 455
Query: 870 MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
L L EL+ ++ + D++Q+ + + K E + + + Q Q+K +S
Sbjct: 456 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 515
Query: 925 LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
HE +++ ++ K NA L + +E++ L E K ++E T+
Sbjct: 516 PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 571
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
+ P+ +EE + + + + + + + +KY ++EE+ K K D LK ++
Sbjct: 572 IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 622
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
D ++ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++
Sbjct: 623 TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 670
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
E + + + + +H L Q+ + ++ ++ L M+ Y K +T+L QL++
Sbjct: 671 LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 724
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
QK +SV + EHLQ+ ++ + +E +K EV+KL+ ++ K A+
Sbjct: 725 AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 782
Query: 1218 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1277
T +V S Y+ +S LE+++S L KL ++ E+V EV+ + + K EKE
Sbjct: 783 --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840
Query: 1278 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1334
+ S EQE+ + ++ ++ + E++R + S+K E KD KI E+ +V +LK+A
Sbjct: 841 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900
Query: 1335 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1394
LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG
Sbjct: 901 LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959
Query: 1395 HMDEDVQEALLQIIQM 1410
MDEDVQ+ L QI+ M
Sbjct: 960 QMDEDVQKVLKQILTM 975
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 261 bits (667), Expect = 3e-69
Identities = 272/1176 (23%), Positives = 509/1176 (43%), Gaps = 136/1176 (11%)
Query: 1 MKSLKSRLRRQDV--------------PGPASSGAAAASAHAADWNKYDDRLMKAAERGD 46
MK+L++R ++ ++ P P AA + DW K D+RL++A E D
Sbjct: 1 MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND 60
Query: 47 VEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALH 106
+V +++A+KG+ P KLD EG+S FH+ +G CL ++ HG ++ ++D AG NALH
Sbjct: 61 APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH 120
Query: 107 LAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVD 166
LAAKYGH CL++LLQ +C + D G TALH AA C S ++LC A +N +D
Sbjct: 121 LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS 180
Query: 167 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 226
G TPL++A QM +C+LL+ +GA N +D Q RTALML CE + VEVL++ GA
Sbjct: 181 GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP 240
Query: 227 SLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWK--KGPSLQQRNLTHMQDEV 284
+ DALG D+++Y + + IL LL+ A++ + L + G + Q +++ +
Sbjct: 241 GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG 300
Query: 285 NVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQ------LQLNEEVMVA 338
K + ++ D E + +++QE+ LL K+ GL+ Q + E
Sbjct: 301 APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL 360
Query: 339 DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQ 398
LE + ++L+ LL ++++ E R +E+L++R E++ N D+ Q
Sbjct: 361 HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENER-------ENTSYDVTTLQ 413
Query: 399 GQMYMADSQCTSPGIP-AHMQSRSMLRPLE----LSLPSQTSY--SENEILKKELEAMRT 451
D + P +P A + L P SL Q + +N+ L ++++ +
Sbjct: 414 ------DEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILEN 467
Query: 452 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 511
F ++D +++ E +AE LAL + ++ + D+ +Q +AL+
Sbjct: 468 F----EKDETQMEVE---ALAEVIPLAL-YDSLRAEFDQLRRQHAEALQ----------- 508
Query: 512 KVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 571
++Q +T + +E AA G + GA+A ++ N
Sbjct: 509 ALRQQETREVPREE----GAACGESEVA---------------GATATKNG-PTHMELNG 548
Query: 572 MIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEK 631
+ E K + + I+E + + ME E G + T A+ AK+ + P
Sbjct: 549 SVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEAT----GAEATGAKVTETKPT-- 602
Query: 632 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK 691
EV E + E E E + + E V+A + K + E
Sbjct: 603 --------GAEVRE--METTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEM 652
Query: 692 SRLEQKSGELGKKITELTLKNQTLQKE-------IEKVYLDNKLLKEQAHNLTIEMKNHY 744
+G+ +T T T + + ++N ++ ++ H
Sbjct: 653 QAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHP 712
Query: 745 VPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFV 804
+ SE ++ + I L L Q+ E E+E L + ++ + RL V
Sbjct: 713 GAAEASEKLQVELETRIRGLEEAL---RQREREAAAELEAALGKCEAAEAEAGRLRE-RV 768
Query: 805 PPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKT 864
+ + +L+ L + ++ + ++ L + + L + +++ +
Sbjct: 769 REAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLA--- 825
Query: 865 HEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 924
EE L LA+ L+ ++ E + ++ + E + A
Sbjct: 826 -EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEAR 884
Query: 925 LAEHEAKMSSLSQSMRKVQDSNAEI------LANYRKGQEEIV-------TLHAEIKAQK 971
+AE A Q + ++++++ + + +R+ QEE + +L E+ A
Sbjct: 885 VAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATG 944
Query: 972 KELDTIQECIKVKYAPIVSFEECER---KFKATEKELKDQLSEQTQKYSVSEEEVKK--- 1025
KE ++ ++ + V+ E ER +A +L+ QL E +++ + EV +
Sbjct: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
Query: 1026 ----NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTE 1081
K E + ++ T ++ LR E++ + + D+ ++ K +++ E
Sbjct: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKE 1064
Query: 1082 VKNVKEKLVEENAK-QTSEILAVQNLLQKQHVPLEQ 1116
V N+KE L E+ A T E+ A+++ ++ L++
Sbjct: 1065 VFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQE 1100
Score = 128 bits (321), Expect = 4e-29
Identities = 98/387 (25%), Positives = 183/387 (47%), Gaps = 32/387 (8%)
Query: 1029 ENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
+ +L+ + ++DLRD+ + E+E A S DE ++ ++ +
Sbjct: 783 DTTQLRAALEQAREDLRDRD---SRLRELEAA-SACLDEARASRLLAEEEARGLRAELAQ 838
Query: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
E +Q+ E+ ++ L EQ L + + + + E+ +Q
Sbjct: 839 REEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQG 898
Query: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
+ +L + E + S VP +EH +++E E ++ E+E +E ++L++E+
Sbjct: 899 LAELREASEALRQSVVPASEHRRLQE----EALELRGRAASLEQEVVATGKEAARLRAEL 954
Query: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1268
+ + V LS+++ L+ ++ L +L L R++E+ EV +++
Sbjct: 955 ERERVCS--------VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREA 1006
Query: 1269 ISAKDEKELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
+ K E+ + EQ+++ + +++ + Q R QE+ + + KD KITEL
Sbjct: 1007 LFMKSERHAAEAQLATAEQQLRGLRTEAERA----RQAQSRAQEALDKAKEKDKKITELS 1062
Query: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
+V LK+AL P + ++ L+ QVK L+QQL +A R H V+A+YR
Sbjct: 1063 KEVFNLKEALKE---------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYR 1113
Query: 1386 THLLSAAQGHMDEDVQEALLQIIQMRQ 1412
+HLL A QG MDEDVQ L QI+QM++
Sbjct: 1114 SHLLYAIQGQMDEDVQRILSQILQMQR 1140
Score = 41.6 bits (96), Expect = 0.005
Identities = 54/225 (24%), Positives = 106/225 (47%), Gaps = 24/225 (10%)
Query: 1131 LKEELKSMQRCYEKEQQT---VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1187
L ++++ +++ E+ QQ + LH L + L E + KE+ +EV +++ L
Sbjct: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRL 395
Query: 1188 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1247
E E +N +V+ LQ E + L L EV+ LS+ + + + ++SL E++
Sbjct: 396 SLLENERENTSYDVTTLQDE----EGELPDLPGAEVL-LSRQLSPSA--QEHLASLQEQV 448
Query: 1248 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1307
A L R+ +E+ E+V + E KDE ++ ++ + I D +L+R+
Sbjct: 449 AVLTRQNQELMEKVQILENFE---KDETQMEVEALAEVI--PLALYDSLRAEFDQLRRQH 503
Query: 1308 QESAKQIEAKDNKITELLNDVERLKQALNGLSQL---TYTSGNPT 1349
E+ + + ++ + +V R + A G S++ T T PT
Sbjct: 504 AEALQALRQQETR------EVPREEGAACGESEVAGATATKNGPT 542
Score = 38.1 bits (87), Expect = 0.060
Identities = 70/339 (20%), Positives = 127/339 (37%), Gaps = 72/339 (21%)
Query: 299 LEIENEDLKERLRKIQQEQRI--LLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 356
LE EDL++R ++++ + LD+ +L EE L++ LA +E
Sbjct: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEA----------RGLRAELAQRE 840
Query: 357 KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 416
+ E R +E L+ + L + ++ + G+ A + A
Sbjct: 841 EARLEQSRELEVLR--------EQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC 892
Query: 417 MQSRSMLRPL----ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVA 472
++R L L E S SE+ L++E +R S +Q+ + E A A
Sbjct: 893 EEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRA 952
Query: 473 E------CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK-- 524
E C E ER+ + QLE L+++ +R ++ +V Q+Q L +K
Sbjct: 953 ELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSE 1012
Query: 525 --------------------------------EHLTSEAASGNHRLTE------ELKDQL 546
+ +A + ++TE LK+ L
Sbjct: 1013 RHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEAL 1072
Query: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
K+ A+ EV LR+Q+K + ++E RD ++
Sbjct: 1073 KEQPAAL--ATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109
Score = 32.7 bits (73), Expect = 2.5
Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 17/175 (9%)
Query: 1236 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDK 1295
L + L +K+ L + E +E A I + +EL +E++ ++KE
Sbjct: 329 LRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQ--EEKE---- 382
Query: 1296 SLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL 1355
L R ++ ++ +N+ DV L+ L L G QL
Sbjct: 383 ------SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLP---GAEVLLSRQL 433
Query: 1356 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1410
+ Q + SL++Q+A RQ+QE++ + +L + + EAL ++I +
Sbjct: 434 SPSAQEHLASLQEQVAVLTRQNQELME--KVQILENFEKDETQMEVEALAEVIPL 486
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 193 bits (490), Expect = 1e-48
Identities = 112/333 (33%), Positives = 179/333 (53%), Gaps = 10/333 (3%)
Query: 31 WNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIH 90
WN++D +L++A RGDV +V ++ ++K P KLD G+S FH+ SKG ECL +L +
Sbjct: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
Query: 91 GVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSI 150
G DI + + G ALHLA C++ LLQ+ + D + R+ LH AA + C SS+
Sbjct: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
Query: 151 QLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEY 210
LLCDH A ++ D DGRTPL++A+ IC L+ RGA VN DK +++AL+L CE
Sbjct: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
Query: 211 GCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGP 270
G + E+L+ +GAD +D+ GHD+ +YA + + L+ A +G + + P
Sbjct: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
Query: 271 SL-QQRNLTHMQDEVNVKSHQREHQNIQDLEIENED---------LKERLRKIQQEQRIL 320
L Q + + Q KS R + E E+ED +E RK+ + ++ L
Sbjct: 257 DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQEL 316
Query: 321 LDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 353
+ K + Q + + + + + ++L LL+
Sbjct: 317 VQKTEECKTQAAAYLDLENQIREQAQELGVLLS 349
Score = 110 bits (275), Expect = 1e-23
Identities = 95/420 (22%), Positives = 189/420 (45%), Gaps = 42/420 (10%)
Query: 1006 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT 1065
K QL ++ +S + +E +L +E LQ++L+ + +++ + +
Sbjct: 610 KGQLEKEMSVLRLSNSNLL---EELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQL 666
Query: 1066 DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL--------QKQHVPLEQV 1117
+L + + L+ + K EKL + A Q+S + + + L Q E +
Sbjct: 667 QQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESL 726
Query: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1177
E L+ ++ ++ +E + + R E+ QQ L E + P + + A E
Sbjct: 727 EELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA---ALE 783
Query: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
+++G ++ LR + K +E+ KL+ + + + +L RE L +++ T+ L
Sbjct: 784 QDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843
Query: 1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQE--IKDQKER 1292
Q + ++L L KY C EV + +E A++ + +L + EQE + + R
Sbjct: 844 AQAQAWGQELKALLEKYNTACREV--GRLREAVAEERRRSGDLAAQAAEQERQASEMRGR 901
Query: 1293 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQ 1352
++ T L+ +++ K+ KI ELL +E+L
Sbjct: 902 SEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL--------------------- 940
Query: 1353 SQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQ 1412
S+ + ++ + L QL D+ + H+E+I+ YR HLL+AA+G+M+ +V LLQI+ M +
Sbjct: 941 SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEE 1000
Score = 51.2 bits (121), Expect = 7e-06
Identities = 74/375 (19%), Positives = 156/375 (41%), Gaps = 58/375 (15%)
Query: 427 ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAECKALALECER 483
EL++ + + ++L + +R + D + Q++ A + E +A C
Sbjct: 679 ELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRA----CIS 734
Query: 484 VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELK 543
D + +Q+ L +Q+ + G + + +LK + + A+ L + L+
Sbjct: 735 TLVDRHREAQQV---LARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGK-LE 790
Query: 544 DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 603
++L+ ++ G S E+GKL+ + Q V E + E + ++++
Sbjct: 791 EELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEK------------- 837
Query: 604 KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 663
+G V + + +EL A L EK+ ++ EV + + E R ++
Sbjct: 838 TRGSLVAQAQAWGQELKALL------EKY----NTACREVGRLREAVAEERRRSGDLAAQ 887
Query: 664 IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG---ELGKKITELTLKNQTLQKEIE 720
+ +R+ ++ + Q K E +K ++E G + KI EL K + L +E+
Sbjct: 888 AAEQERQASEMRGRSEQFEKTA--ELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEV- 944
Query: 721 KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 780
L I +N + L++ +D +K+H+ II LL+ + Y E
Sbjct: 945 ---------------LAIRGENARLALQL-QDSQKNHEEIISTYRNHLLNAARGYMEH-- 986
Query: 781 EMEKLLLENDSLSKD 795
E+ +LL+ S+ ++
Sbjct: 987 EVYNILLQILSMEEE 1001
Score = 48.5 bits (114), Expect = 4e-05
Identities = 70/355 (19%), Positives = 159/355 (44%), Gaps = 54/355 (15%)
Query: 781 EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 840
E ++L E SLS+ RL+ FVP + + ++ L+ ++ L +L+ ++K+ E K
Sbjct: 637 ERQRLQRELQSLSQ---RLQREFVPKPEAQVQLQQLRQSVGLLTNELA-MEKEATEKLRK 692
Query: 841 IHALTSENTNLKKMM-----------SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKK 889
+ L S+++ L+ + S Q ++ EE++ ++ TL +RE V +
Sbjct: 693 L--LASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACIS-TLVDRHREAQQVLAR 749
Query: 890 FEDINQEF-------------VKIKDKNEI--LKRNLENTQNQIKAEYISLAEHEAKMSS 934
++ NQ+ +K ++ L+++L + +++A +++ ++
Sbjct: 750 LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809
Query: 935 LSQSMRKVQDSNAEI----LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
L Q + + + AE+ A+ R+ ++ +L A+ +A +EL + E +
Sbjct: 810 LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869
Query: 991 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1050
E + + +L Q +EQ ++ S ++ ++ + LK+++ L RDK
Sbjct: 870 LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDK--- 926
Query: 1051 IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL---VEENAKQTSEILA 1102
K EL K+L+ LS++ ++ +L ++++ K EI++
Sbjct: 927 -----------EAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIIS 970
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 182 bits (462), Expect = 2e-45
Identities = 270/1176 (22%), Positives = 503/1176 (42%), Gaps = 199/1176 (16%)
Query: 298 DLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN-------EEVMVADDLESEREKLKS 350
D++ E EDL + +EQ L+ ++ ++ L+ E V L+ E++KL+
Sbjct: 119 DMDSEAEDLVGNSDSLNKEQ--LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 351 LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 410
+L+ + ++SLR I L+ + + F D L++ Y++ Q
Sbjct: 177 ILSQSQ---DKSLRRIAELREELQMDQQAKKHLQEEF-----DASLEEKDQYISVLQTQV 228
Query: 411 PGIPAHMQSRSM----LRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNE 466
+ +++ M L+PL P + E+ KE E+ + D
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEP------QAEVFTKE--------ENPESDG------ 268
Query: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
E V ED +K LE +Q+R+ E +K+ + + KE
Sbjct: 269 ---------------EPVVEDGTS-VKTLET----LQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 527 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 586
T S L E+L ++L++L+ + AE KL Q++ + ++E+ ++D+G +I
Sbjct: 309 CTL-LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA 367
Query: 587 ENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN-EVN 644
E KR E L M E E + ++ +M Q +EL + S A FE ++ +LS +
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA-FEELEKALSTAQKT 426
Query: 645 EKAKKLVEMEREH-----EKSLSEIR-QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 698
E+A++ ++ E + EK+ E R L++EL VK ++ +K EQ+ +
Sbjct: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
Query: 699 GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 758
EL +K ELT K QT ++E ++ + L K Q+ L I + E+++
Sbjct: 487 KELARKEQELTKKLQTREREFQE-QMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545
Query: 759 AIIDDLNRKLLDVTQK---YTEKKLEME----KLLLENDSLSKDVS-RLETVFVPPEKHE 810
AI+ + KL D+ Q+ Y + LE+E K L EN + SKD++ LE KH
Sbjct: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA---EKNKHN 602
Query: 811 KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 870
KEI + + + K +L LK H + T +++ QY
Sbjct: 603 KEITVM---VEKHKTELESLK----------HQQDALWTEKLQVLKQQY----------- 638
Query: 871 TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 930
E+ +++K E + +KDK I + ++E N+ E + + + E
Sbjct: 639 ---------QTEMEKLREKCEQEKETL--LKDKEIIFQAHIEE-MNEKTLEKLDVKQTE- 685
Query: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
+ SLS + +E+L K +EE+ L + K+EL+ + K + V
Sbjct: 686 -LESLSSEL-------SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD 737
Query: 991 --FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT 1048
+E E + TEK LKDQ+++ ++ +K+++ + L+ +I + +L+ +
Sbjct: 738 SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS 797
Query: 1049 VLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK---EKLVEENAKQTSEI----- 1100
++ + A +T +QL L QK +++ + K V E Q ++
Sbjct: 798 AKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD 857
Query: 1101 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENL-----KEELKSMQRCYEKEQQTVTKL 1152
+ VQ+L+Q+ ++E KSL E+ KE+ ++ Q EKE +
Sbjct: 858 AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL--- 914
Query: 1153 HQLLENQKNSSVPLAEHLQIKEAF---------------EKEVGIIKASLREKEEESQNK 1197
Q+ E QK L + L KE EK++ +K +E +E + K
Sbjct: 915 -QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973
Query: 1198 -MEEVSKLQSEVQNT--------------------------KQALKKLETREVVDL-SKY 1229
+++ +KL+ E++NT A+ +LET + + S
Sbjct: 974 LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033
Query: 1230 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1289
+ + +L IS +KL + +E+ E L K++E++ +K LL ++E+ +
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 1290 ----KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN-GLSQLTYT 1344
KE K TT+ ELQ ++++ + + + T+L +E+L+ LN L + T+
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 1345 SGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
+ + L + + +V L +L D + Q +
Sbjct: 1154 QEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSL 1188
Score = 171 bits (433), Expect = 5e-42
Identities = 248/1170 (21%), Positives = 515/1170 (44%), Gaps = 154/1170 (13%)
Query: 282 DEVNVKSHQREHQNIQDLEIENEDLKERLR---KIQQEQRILLDKVNGLQLQLNEEVMVA 338
+E+N K+ ++ +LE + +L E L+ K+++E +L D+ + ++ +L E +
Sbjct: 669 EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL--EAKMD 726
Query: 339 DDLESEREKLKSLLAAKEKQHEESL-RTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLK 397
+ ++++ S++ K+HE S+ RT +ALK++ E ++ D LK
Sbjct: 727 EQKNHHQQQVDSII----KEHEVSIQRTEKALKDQINQLE---------LLLKERDKHLK 773
Query: 398 QGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAK 457
+ Q ++ + + +Q S + S S T + + + +++L ++ +
Sbjct: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT-HEQTKAYEEQLAQLQQKLLDLE 832
Query: 458 QDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM------YES-- 509
+R+ L ++A A+ K + E + K + ++QLE ++++++ YES
Sbjct: 833 TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL 892
Query: 510 -EGKVKQMQT-HFLALKEHLTSEAASGNHR----LTEEL---KDQLKDLKVKYEGASAEV 560
+G +Q QT L KE++ + G + LT++L +D + L +YE
Sbjct: 893 EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952
Query: 561 GKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS 620
K ++KQ ++E + KL+++ +L+KEL +E +K K+ +
Sbjct: 953 EKKMEKVKQKAKEMQETLKK--KLLDQEAKLKKELENTALELSQK----------EKQFN 1000
Query: 621 AKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV----KA 676
AK+ M + S +++ +L ++E +SL+E+ +REL +V +
Sbjct: 1001 AKML---------EMAQANSAGISDAVSRLETNQKEQIESLTEVH--RRELNDVISIWEK 1049
Query: 677 KLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAH 734
KL Q + E HE EQ+ EL +KI + + + KEI +L + +K+
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI--TWLKEEGVKQDT- 1106
Query: 735 NLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSK 794
L ++ K A ++ L Q T+ K +EKL ++ L+K
Sbjct: 1107 -----------TLNELQEQLKQKSAHVNSL-------AQDETKLKAHLEKLEVD---LNK 1145
Query: 795 DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 854
+ E F+ +++++ LK E K+++SEL K E+ +L S + K
Sbjct: 1146 SLK--ENTFL-----QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Query: 855 MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 914
+ ++ + K E D K LL+ K E IN + N IL R + +
Sbjct: 1199 LEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN-ELIN---ISSSKTNAILSR-ISHC 1253
Query: 915 QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 974
Q++ +L +S L +R++ + + ++++ ++ +IK+ K ++
Sbjct: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADI 1313
Query: 975 DTIQECIKVKYAPIVSFEECERKFKATEKE-----LKDQLSEQTQKYSVSEEEVKKNKQE 1029
+++ V + E ++ A+EKE LK +LSE ++ +EE+K+ K E
Sbjct: 1314 ESL-----VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368
Query: 1030 NDKLKKEIFTLQKDLRDKTVLIE---------KSHEMERA--------LSRKTDELNK-- 1070
L K++ L L++ L E K ++ E+ LS K D L+K
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
Query: 1071 -----QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ-HVPLEQVEALKKSL 1124
Q+ D S K++E K + ++ E+ L K+ + EQ+ LK+ L
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488
Query: 1125 ---NGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE-AFEKEV 1180
N + LK E++ + EK++ + L L++Q + L +H+ K E
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKE---SNLETELKSQTARIMELEDHITQKTIEIESLN 1545
Query: 1181 GIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQI 1240
++K ++K+ E + ++++ Q + +K+ E + + ++ + K++LET+
Sbjct: 1546 EVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605
Query: 1241 SSLNEKLANLNRKYEEV------CEEVLHAKKKEISAKDEKEL--LHFSIEQEIKDQKER 1292
L ++ K EE+ E AK E+ K E+++ + + ++++++E+
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665
Query: 1293 CDKSLTT-ITELQRRIQESAKQIEAKDNKITEL-LNDVERLKQALNGLSQLTYTSGNPTK 1350
K + ++EL ++QE +++ + K+ + + E L + + YT
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
Query: 1351 RQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
Q + T + ++ L++ L + ++ Q V
Sbjct: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Score = 167 bits (422), Expect = 9e-41
Identities = 256/1165 (21%), Positives = 497/1165 (42%), Gaps = 150/1165 (12%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 308
+ L E NK K+ Q L +Q+++ KS ++ L + LK
Sbjct: 1080 ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS-----AHVNSLAQDETKLKA 1134
Query: 309 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ-------HEE 361
L K++ + L + LQ QL E M+A++ + + +L S L +++ HE+
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 362 SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLL--KQGQMYMADSQCTSPGIP--AHM 417
S +++E FK S+ L +K + LL K ++ S T+ + +H
Sbjct: 1195 SNKSLEDKSLEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 418 QSRSMLRPLELSLPSQTSYSENEILKKEL-EAMRTFCESAKQDRLKLQ---NELAHKVAE 473
Q R+ + E L + SE E ++L E T S +Q +L+ N++ A+
Sbjct: 1254 QHRTT-KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312
Query: 474 CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 533
++L E E ++++ Q Q+ E E + Q LK+ L S
Sbjct: 1313 IESLVTEKEALQKEGGNQ-----------QQAASEKESCITQ-------LKKEL-----S 1349
Query: 534 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK 593
N +K++LK+ KV+ S ++ L Q+ QN + + E + L R Q
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSL-----RKQY 1403
Query: 594 ELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
+ CE+ + + +++SA + + KF K + + + E+
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
Query: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVK-----PEEHEQVKSRLEQKSGELGKKITEL 708
+ + E E + ++ +K +L Q K E E KS++E+K L ++
Sbjct: 1464 QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
Query: 709 TLKNQTLQKEIEKVYLD----NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 764
T + L+ I + ++ N++LK IE K L+ +++ + D + +
Sbjct: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEA 1583
Query: 765 NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV-EL 823
K+L + + K E+E E LE V + + E+E+ AL+ + E
Sbjct: 1584 EEKILTLENQVYSMKAELETKKKE----------LEHVNLSVKSKEEELKALEDRLESES 1633
Query: 824 KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 883
+L+ELK+K ++KI A+ + + + QY K E LN L + RE+
Sbjct: 1634 AAKLAELKRKA---EQKIAAIKKQLLSQMEEKEEQYK--KGTESHLSELNTKLQEREREV 1688
Query: 884 LDVKKKFEDINQEFVKIKDKNEILKRNLENT-----QNQIKAEYISLAEHEAKMSSLSQS 938
+++K + + + + I+ R+ +N Q + ++ +E K+S L ++
Sbjct: 1689 HILEEKLKSVESS----QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744
Query: 939 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 998
+ + + ++L + +EE V+ H E++ Q +E IK+++A E+
Sbjct: 1745 LTEKE----KLLQRVGQEKEETVSSHFEMRCQYQE-----RLIKLEHAEAKQHED----- 1790
Query: 999 KATEKELKDQLSEQTQKYS------VSEEEVKKNKQENDKLKKEIFTLQKDLRDKT---- 1048
++ L+++L E+ +KYS V +E K N Q L+ +QK L++K
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850
Query: 1049 VLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV--------KNVKEKLVEENAKQTSEI 1100
+L +K E++ L R+ + ++++L+ KY ++ +N +L+EEN ++ S+
Sbjct: 1851 ILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 1101 LAVQNLL----QKQHVPLE----QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
VQ L + QH LE E K+ L I L+++L+ +++ +++E + + K
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970
Query: 1153 HQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTK 1212
+ +K E L++K +K +RE + K +E+ K
Sbjct: 1971 YDQEREEKIKQEQ--EDLELKHN-----STLKQLMREFNTQLAQKEQELE------MTIK 2017
Query: 1213 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAK 1272
+ + K + E L ++ + L +I+ ++ L ++Y EE+L A+++E++AK
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY----EEILDAREEEMTAK 2073
Query: 1273 -----DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1327
+ E L +Q++ +Q+E TI ELQ ++ + I K E
Sbjct: 2074 VRDLQTQLEELQKKYQQKL-EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132
Query: 1328 VERLKQALNGLSQLTY--TSGNPTK 1350
+ L+ L + Y T G P K
Sbjct: 2133 IHNLEDRLKKYEKNVYATTVGTPYK 2157
Score = 162 bits (409), Expect = 3e-39
Identities = 275/1365 (20%), Positives = 559/1365 (40%), Gaps = 254/1365 (18%)
Query: 253 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNI---QDLEIENEDLKER 309
+ A E K +K +++ M +++ E + I Q+L +++ +
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469
Query: 310 LRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 369
++K +EQ L K++ +L E+ + ERE + + A EK E L+ +
Sbjct: 470 MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 370 KNR----FKYFESDHLGSGSHFSNRKEDMLLKQGQMY--------------MADSQCTSP 411
+ + + E + N+ D L ++ + Y + +++ S
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRD-LQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 412 GIPAHMQSRSMLRPLELSLPSQTSYSENEILK-------------------KELEAMRTF 452
+ H+++ E+++ + +E E LK E+E +R
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 453 CESAKQDRL----------------KLQNELAHKVAECKALALECERVKEDSDEQIKQLE 496
CE K+ L K +L K E ++L+ E V + + ++L
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 497 DALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQ----------- 545
K E E K+ + + H + + E R + LKDQ
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 546 ---LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK-------RLQKEL 595
LK+ + E A++ + +++Q ++ F+ + E+ K +LQ++L
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 596 SMCEMEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEME 654
E ER ++V E+E Q K++ +L A I + ++E+ +K K L ++
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 655 R------------------EHEKSLSEIRQ-LKRELENVKAKLAQ-----HVKPEEHEQV 690
E E + ++R+ K+E+E + KL+ H+ EE+E
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 691 KSRLEQKSGELGKKITEL--TLKNQ------TLQKEIEKVYLDNKLLKEQAHNLTIEMKN 742
E+K ++ +K E+ TLK + L+KE+E L+ ++Q + +EM
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQ 1008
Query: 743 ------HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN------D 790
++ + K+ +++ + R+L DV + EKKL + L+
Sbjct: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW-EKKLNQQAEELQEIHEIQLQ 1067
Query: 791 SLSKDVSRLETVFV----PPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTS 846
++V+ L+ + E+ KEI LK V+ L+EL+++ + +++L
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 847 ENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA-------KTNRELLDVKKKFEDINQEFVK 899
+ T LK + V + + L + L + R++ ++ K + ++EF
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 900 IKDKNEILKRNLENTQNQIKAEYISLA--------EHEAKMSSLSQSMRKVQDSNAE-IL 950
+K +E ++LE+ + K LA + EA + + + + + S IL
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247
Query: 951 ANYRKGQEEIVTLH----------AEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFK 999
+ Q + +E++AQ ++L Q + + + EE E + K
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307
Query: 1000 ATEKELKDQLSEQ--TQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHE 1056
+ + +++ ++E+ QK ++++ K+ +LKKE L +++ T++ E+ E
Sbjct: 1308 SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE---LSENINAVTLMKEELKE 1364
Query: 1057 ME---RALSRKTDELNKQLKD---LSQKYTEVKNVKEKLVEENAKQTSEI----LAVQNL 1106
+ +LS++ +LN QL++ LS+K + +++++ EE + ++ V L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424
Query: 1107 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166
+++ LEQV+ + E K Q + + Q TV +L LE
Sbjct: 1425 SKEKISALEQVDDWSNKFS-------EWKKKAQSRFTQHQNTVKELQIQLE--------- 1468
Query: 1167 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1226
L+ KEA+EK+ I +L ++E + QNK + L+ E+++ K ++K E+ +L
Sbjct: 1469 ---LKSKEAYEKDEQI---NLLKEELDQQNKRFDC--LKGEMEDDKSKMEKKESNLETEL 1520
Query: 1227 SKYKATKSDLE-------TQISSLNEKLANLNRK--------------YEEVCEE----- 1260
A +LE +I SLNE L N N++ ++E+ EE
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 1261 ------------VLHAKKKEISAKDEKELLHFSI-----EQEIKDQKERCD-KSLTTITE 1302
+++ K E+ K +KEL H ++ E+E+K ++R + +S + E
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETK-KKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
Query: 1303 LQRRIQESAKQIEAKDNKITELLNDVERLKQALNG-LSQLTYTSGNPTKRQSQLIDTLQH 1361
L+R+ ++ I K ++++ E+ K+ LS+L TK Q + +
Sbjct: 1640 LKRKAEQKIAAI--KKQLLSQMEEKEEQYKKGTESHLSELN------TKLQER-----ER 1686
Query: 1362 QVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1406
+V LE++L + E + + R+ AA +E + +Q
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 181 bits (460), Expect = 3e-45
Identities = 251/1181 (21%), Positives = 513/1181 (43%), Gaps = 189/1181 (16%)
Query: 281 QDEVNVKSHQREHQNIQDLEIEN--EDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVA 338
Q E + K H+ E + +L+ EN + + + IQ++ L+ + N++ +
Sbjct: 258 QIEASAKEHEAEINKLNELK-ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316
Query: 339 DDLESEREKLKSLLAAKEKQHEESLRTIEA----LKNRFKYF-------ESDHLGSGSHF 387
L E ++ ++ K K E++L+ +E+ LK+ Y E D F
Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376
Query: 388 SNRKEDMLLKQGQMYMADSQ--CTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE 445
+ +ED+ K ++ +A + C + + + + + ++ S E +KE
Sbjct: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436
Query: 446 L-EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQI---KQLEDALKD 501
+ E TF +++++L L E+ + L +CE ++++ E I + L + ++
Sbjct: 437 ISELNETFLSDSEKEKLTLMFEI-------QGLKEQCENLQQEKQEAILNYESLREIMEI 489
Query: 502 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 561
+Q + ES GK+ Q F ++K+ + AS H L +
Sbjct: 490 LQTELGESAGKISQ---EFESMKQ----QQASDVHELQQ--------------------- 521
Query: 562 KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSA 621
KLR + + ++E R +G EN++L LS E+ V E+E K L
Sbjct: 522 KLRTAFTEKDALLETVNRLQG----ENEKL---LSQQEL--------VPELENTIKNLQE 566
Query: 622 K-----LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 676
K L+LS + ++ +++ EK + +++ HE+ + ++ +RE E +
Sbjct: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE-ERLIL 625
Query: 677 KLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 736
+L + V E+ Q S LEQK EL + E + +++EK+ + K+L E L
Sbjct: 626 ELGKKV--EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683
Query: 737 TIEMKNHYVPL-KVSEDMKK-SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSK 794
+ E+K+ Y K+S + K+ S D + ++ + + + T+ + +++ ++ E D+L+K
Sbjct: 684 SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743
Query: 795 --DVSRLETVFVPPEKH---------------EKEIIALKSNIVELKKQLSELKKKCG-- 835
+ +++ +FV + + EK+++ + + E +++E +KC
Sbjct: 744 LLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE--EKCNLA 801
Query: 836 -EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT---NRELLDVKKKFE 891
+ EK+ L E +K + V EE+K L D + +EL +++ + E
Sbjct: 802 FQRDEKVLELEKE---IKCLQEESVVQC---EELKSLLRDYEQEKVLLRKELEEIQSEKE 855
Query: 892 DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 951
+ + +++K+ NE K LEN I+ E +S ++++ + + + N + L
Sbjct: 856 ALQSDLLEMKNANE--KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 952 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSE 1011
Q+E+ AE+ K D++ + VK P+ S +E E K + EKE K++
Sbjct: 914 E----QKELRDRRAELILLK---DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK--- 963
Query: 1012 QTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQ 1071
EE++ K K K KKE+ + +K+ + TV E+E S K D+L+
Sbjct: 964 --------EEKINKIKLVAVKAKKELDSSRKETQ--TV----KEELESLRSEK-DQLSAS 1008
Query: 1072 LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENL 1131
++DL Q KN L+ E KQ+ ++ V E+ + + L
Sbjct: 1009 MRDLIQGAESYKN----LLLEYEKQSEQL----------DVEKERANNFEHRIEDLTRQL 1054
Query: 1132 KEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKE 1191
+ + + + ++ L N K V + E + K +KE+ K +K
Sbjct: 1055 RNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI 1114
Query: 1192 EESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK--------SDLETQISSL 1243
+E + E+ +LQ ++Q K+ L+K T + ++L K A + +D E + L
Sbjct: 1115 KEHATTVNELEELQVQLQKEKKQLQK--TMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 1244 NEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ-----------------EI 1286
N+KL N N K E++ +E+ K+K+ + ++E L S++Q E+
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1232
Query: 1287 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
D K+ L L+ ++ S +Q+E ++ E+ ++ ++ + L
Sbjct: 1233 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK---------- 1282
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTH 1387
++ + + Q +V +L+++ A + V + + ++
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY 1323
Score = 149 bits (377), Expect = 1e-35
Identities = 244/1115 (21%), Positives = 471/1115 (42%), Gaps = 186/1115 (16%)
Query: 243 GDNLDILTLLKTASENTNKGRELWKKGP----SLQQRN--LTHMQDEVNVKSHQREHQNI 296
G+N +L+ + E N + L +K SL QR+ L ++ ++N + +++ I
Sbjct: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD-DFI 600
Query: 297 QDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 356
L+ +E++ +K ++E+R++L+ L ++ + + +LE + +L L
Sbjct: 601 NKLKNSHEEMDNFHKKCEREERLILE----LGKKVEQTIQYNSELEQKVNELTGGLEETL 656
Query: 357 KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 416
K+ +++ + +E L + K D KE + + +Y +++ +S
Sbjct: 657 KEKDQNDQKLEKLMVQMKVLSED-----------KEVLSAEVKSLYEENNKLSS------ 699
Query: 417 MQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESA--KQDRLK--LQNELAHKV- 471
+ + + R LE+ L S E+ ILK+ + + + +QD L L+NE K+
Sbjct: 700 -EKKQLSRDLEVFL----SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLF 754
Query: 472 --AECKALALEC-ERVKEDSDEQ-----IKQLEDALKDVQKRM----YESEGKVKQMQTH 519
+ E V EDS+E+ ++ + ++L + + ++ + KV +++
Sbjct: 755 VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKE 814
Query: 520 FLALKEHLTSEAASGNHRLTEELKDQLKD-------LKVKYEGASAEVGKLRNQIKQNEM 572
L+E + EELK L+D L+ + E +E L++ + + +
Sbjct: 815 IKCLQEESVVQC--------EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
Query: 573 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEG-----QAKELSAKLA--- 624
E+ + + L+ + + + + S E+ EK+ + E E + KEL + A
Sbjct: 867 ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI 926
Query: 625 -LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVK 683
L K ++K+ + V E +K+ +E+E ++ +I ++K L VKAK
Sbjct: 927 LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK--LVAVKAKKELDSS 984
Query: 684 PEEHEQVKSRLEQKSGE---LGKKITEL-----TLKNQTLQKEIEKVYLDNKLLKEQAHN 735
+E + VK LE E L + +L + KN L+ E + LD + KE+A+N
Sbjct: 985 RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE--KERANN 1042
Query: 736 -------LTIEMKNHYVPLKVSEDMKKSHDAIIDDL--NRKLLDV-------TQKYTEKK 779
LT +++N + + + A I+ L N KLL+V + +K+
Sbjct: 1043 FEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
Query: 780 LEMEKLLLEND--SLSKDVSRLETVFVPPEKHEKEI-----------------IALKSNI 820
LE EKL E + V+ LE + V +K +K++ + I
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI 1162
Query: 821 VELKKQLSELKKKCGEDQEKIHALTSE-------NTNLKKMMSNQYVPVKTHEEVKMTLN 873
+ ++ + EL +K KI L E L++ +++ V+ +EE +
Sbjct: 1163 ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK 1222
Query: 874 DTLAKTNRELLDVKKKFED--INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
L KT +EL D K+ D I Q LK LE +Q Q++ I LAE ++
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQAS---------LKGELEASQQQVEVYKIQLAEITSE 1273
Query: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF 991
+ + ++ + + L+ Y Q+ + L E +A K E T+
Sbjct: 1274 KHKIHEHLKTSAEQHQRTLSAY---QQRVTALQEECRAAKAEQATVTS------------ 1318
Query: 992 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLI 1051
+F++ + + + L +Q K S+S+ E + KQE + L+ I L+ L+D +
Sbjct: 1319 -----EFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 1052 EKSHEMERALSRKTDEL----NKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL 1107
+ + + L + D L NK L++ K E++ + EN SE + L
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1432
Query: 1108 QKQHVPL-----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1162
Q+ L +QV L++ T+E L+++L M+ +L QL +N+ +
Sbjct: 1433 TSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKME----------AQLFQL-KNEPTT 1481
Query: 1163 SVPLAEHLQIKEAFEKE------VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1216
P++ +K E+ + + + E E E VS + Q+ +Q L
Sbjct: 1482 RSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
Query: 1217 KLETREVVDLSKYKATKSDLETQISSLNEKLANLN 1251
ET+ L + TK +L ++SS + +LN
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLN 1576
Score = 139 bits (350), Expect = 2e-32
Identities = 228/1082 (21%), Positives = 458/1082 (42%), Gaps = 186/1082 (17%)
Query: 442 LKKELEAMRTFCES--------AKQDRLK-LQNELAHKVAECKALALECERVKEDSDEQI 492
L+KE+E +R+ + A +RL L E A +C +L E ++K++ ++ +
Sbjct: 51 LEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSV 110
Query: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVK 552
++ DA K+++ Q+H +KE E LK++L ++ K
Sbjct: 111 TKMGDAHKELE-------------QSHINYVKE-------------IENLKNELMAVRSK 144
Query: 553 YEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKEL---------------SM 597
Y A + K + ++ + E + + + K+LQ+E+
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204
Query: 598 CEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 655
+ ++K VT+++ +A + ++ E+ +K+ EV E ++ +
Sbjct: 205 LDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAK 264
Query: 656 EHEKSLSEIRQLKREL-ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 714
EHE ++++ +LK L + +A K E E R + +I + L+ T
Sbjct: 265 EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENT 324
Query: 715 LQKEI--EKV-YLDNKLLK-EQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 770
+++ EKV +L++ L + E H++ + + LK+ +M H I D+ + D
Sbjct: 325 FVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH--IKDEFFHERED 382
Query: 771 VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIALKSNIVELKKQLSE 829
+ K E L E+ + L +++ L F E+H +E+ +LK + +K++SE
Sbjct: 383 LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE---QHQKEISE 439
Query: 830 LKKKCGEDQEK--------IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR 881
L + D EK I L + NL++ + ++ E+ L L ++
Sbjct: 440 LNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAG 499
Query: 882 ELLDVKKKFEDINQEFVKIKDKNEIL---------KRNLENTQNQIKAEYISLAEHEAKM 932
+ + ++FE + Q+ + D +E+ K L T N+++ E L + +
Sbjct: 500 K---ISQEFESMKQQ--QASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554
Query: 933 SSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF- 991
L +++ +Q+ N L + + + L +I + +E D +K + + +F
Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
Query: 992 EECERK-------------------------------FKATEKELKDQLSEQTQKYSV-- 1018
++CER+ + T KE KDQ ++ +K V
Sbjct: 615 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE-KDQNDQKLEKLMVQM 673
Query: 1019 ---SEE------EVKKNKQENDKLKKEIFTLQKDL------RDKTVLIEKSHEMERALS- 1062
SE+ EVK +EN+KL E L +DL ++ +L E ++E+ L
Sbjct: 674 KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 1063 --RKTDELNKQLKDLSQKYTEVKNVKEKLVEE---NAKQTSEILAVQNLLQKQHVPLEQV 1117
+ D LNK L++ + VK ++E + SE V N+LQ L ++
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQT-VTKLHQLLENQKNSSVPLAEHLQ----I 1172
K +L + EL+ +C ++E +L LL + + V L + L+
Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
Query: 1173 KEAFEKEVGIIKASLREKEEESQN---KMEEVSKL--QSEVQNTKQA--LKK-------L 1218
KEA + ++ +K + + E+QN ++EEVS+ +SE+ N K+ +K+ L
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 1219 ETREVVD-----------LSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV------ 1261
E +E+ D L+K + K+D + + L EK+ NL ++ +E E++
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLV 973
Query: 1262 -LHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE-------LQRRIQESAKQ 1313
+ AKK+ S++ E + + +E ++ +K++ S+ + + L ++ ++Q
Sbjct: 974 AVKAKKELDSSRKETQTVKEELE-SLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 1032
Query: 1314 IEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADA 1373
++ + + + +E L + L + T + + I+TLQ K LE Q+ +
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
Query: 1374 DR 1375
R
Sbjct: 1093 QR 1094
Score = 85.5 bits (210), Expect = 3e-16
Identities = 142/680 (20%), Positives = 288/680 (42%), Gaps = 100/680 (14%)
Query: 817 KSNIVELKKQLSELKKKCGED---------QEKIHALTSENTNLKKM---MSNQYVPVKT 864
KS EL+K++ EL+ K + E++ AL E ++ + + + +K
Sbjct: 45 KSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQ 104
Query: 865 HEEVKMT-LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI 923
E +T + D + + ++ K+ E++ E + ++ K K NL+ + +
Sbjct: 105 EVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQL 164
Query: 924 SLAEHEAKMSSLSQSMRKVQDSNAEILANYRK--------------GQEEIVT-----LH 964
L+E ++ +++K+Q+ +I + + ++E VT +
Sbjct: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
Query: 965 AEIKAQKKELDTIQE---CIKVKYAPIVSFEECERKFKATE--------KELKDQLSEQT 1013
A + +K ++++QE +K + V C+ + A E ELK+ L +Q
Sbjct: 225 ANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC 284
Query: 1014 QKYSVSEEEV-KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQL 1072
+ SE+ + KK + E + L+K +D + ++L++++ +E+ ++ K L L
Sbjct: 285 E---ASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTL 341
Query: 1073 KDLSQKY-------TEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1125
K+L ++ T + N+K KL + E + L+ + ++ K+
Sbjct: 342 KELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE---FKINELLLAKEEQG 398
Query: 1126 GTIENLKEELKSM--QRCYEKEQ-----QTVTKLHQ----------LLENQKNSSVPLAE 1168
IE LK EL + Q CY EQ Q++ + HQ L +++K + E
Sbjct: 399 CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 458
Query: 1169 HLQIKEAF-----EKEVGIIK-ASLREKEEESQNKM-EEVSKLQSEVQNTKQALKKLETR 1221
+KE EK+ I+ SLRE E Q ++ E K+ E ++ KQ + +
Sbjct: 459 IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQ-QASDVH 517
Query: 1222 EVVDLSKYKATKSD--LET--QISSLNEKLANLNRKYEEVCEEVLHAKKKE---ISAKDE 1274
E+ + T+ D LET ++ NEKL + E+ + + ++K + + +
Sbjct: 518 ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 577
Query: 1275 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER---- 1330
++ + +E +I E D + + + K+ E ++ I EL VE+
Sbjct: 578 RDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637
Query: 1331 ---LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIY-RT 1386
L+Q +N L+ + + Q ++ L Q+K L + D + EV ++Y
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE---DKEVLSAEVKSLYEEN 694
Query: 1387 HLLSAAQGHMDEDVQEALLQ 1406
+ LS+ + + D++ L Q
Sbjct: 695 NKLSSEKKQLSRDLEVFLSQ 714
Score = 53.1 bits (126), Expect = 2e-06
Identities = 99/507 (19%), Positives = 202/507 (39%), Gaps = 59/507 (11%)
Query: 253 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 312
K + T + EL KK QQ L +M+ + + +Q + + + EDL++ ++
Sbjct: 1135 KKQLQKTMQELELVKK--DAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKI 1192
Query: 313 IQQEQRILLDKVNGLQ---------------LQLNEEVMVADDLESEREKLKSLLAAKEK 357
+Q+Q L +++ LQ L + + +AD ++E + L L A+ +
Sbjct: 1193 QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL-ILQASLKG 1251
Query: 358 QHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED----MLLKQGQMYMADSQCTSPG- 412
+ E S + +E K + S+ H E + Q ++ +C +
Sbjct: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311
Query: 413 ----IPAHMQSRSML--RPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNE 466
+ + +S + L+ S +E E K+E E + + K QN
Sbjct: 1312 EQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNN 1371
Query: 467 LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
L V+E + L E + + E ++ +++ ++++++ + + M++
Sbjct: 1372 LQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ 1431
Query: 527 LTSEAASGNHRLTEELKDQLKDLKVKY----EGASAEVGKLRNQIKQ--NEMIVEEFKRD 580
LTS+ N L +DQ++ L+ ++ E ++ K+ Q+ Q NE
Sbjct: 1432 LTSQ----NEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSS 1487
Query: 581 EGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS 640
+ L +R +L + +M VT EG+ E + ++S + ++++ L+
Sbjct: 1488 QQSLKNLRERRNTDLPLLDM------HTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
Query: 641 NEVNE----------KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 690
+ + ++LV+ KS + L RE E A L + +K + E
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE-- 1599
Query: 691 KSRLEQKSGELGKKITELT-LKNQTLQ 716
R +++ E K L LKN LQ
Sbjct: 1600 -IRRLERNQEREKSAANLEYLKNVLLQ 1625
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 178 bits (452), Expect = 3e-44
Identities = 249/1159 (21%), Positives = 503/1159 (43%), Gaps = 162/1159 (13%)
Query: 257 ENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-----QNIQDLEIENEDLKERLR 311
E K L ++ LQQ + + ++ +K+ +E+ +N ++L + ++LK++
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 312 KIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAKEKQHE--ESLRT 365
+ QE+ + K L + V + L+ + +EK + LL +E+ E + +
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 366 IEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP 425
IE LKN K E + H + ++ K + Y T + R +L+
Sbjct: 1160 IENLKNELKNKEL----TLEHMETERLELAQKLNENYEEVKSIT--------KERKVLKE 1207
Query: 426 LELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQ------NELAHKVAECKALAL 479
L+ S ++ + I + E ++T E K + L+ +EL V+E A +
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQII 1266
Query: 480 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 539
+ + E S ++++ L + Q+ + + +V + Q L E LT ++ + +
Sbjct: 1267 NTQDL-EKSHTKLQEEIPVLHEEQE-LLPNVKEVSETQETMNEL-ELLTEQSTTKDSTTL 1323
Query: 540 EELKDQLKDLKVKYEGASAEVGKL---RNQIK--------QNEMIVEEFKRDEGKLIEEN 588
++ + L K++ + E+ L R+ +K +++ + E + K+ E
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
Query: 589 KRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAK 648
+ ++ L+M E + E + V+EME + SA L + I +E+ AK
Sbjct: 1384 SKQEQSLNMKEKDNETT-KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442
Query: 649 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK----SRLEQKSGELGKK 704
+ +++R E SE QLK EN+K +A+H++ EE +V E+ EL
Sbjct: 1443 EKDDLQRLQEVLQSESDQLK---ENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499
Query: 705 ITELTLKNQTLQKEIEKVY--LDNKLL----KEQAHNLT--IEMKNHYVPLKVSEDMKKS 756
++E + T+QK++E + L NK+ KE+ N+ E++ LK ++ +K+
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 757 HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIAL 816
D+ + + K+L++T + E + E++ ++ E + + + L+ +++ KEI+A
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619
Query: 817 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL 876
E + Q ++ E QEK+ E +LK+ Q + ++ E + L L
Sbjct: 1620 MKESQEKEYQFLKMTA-VNETQEKM----CEIEHLKEQFETQKLNLENIETENIRLTQIL 1674
Query: 877 AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT-------QNQIKAEYISLAEHE 929
+ E+ V K+ +D+ +K + + LK NL T Q ++K ++ L EH+
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734
Query: 930 A-----------KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 978
K + +S + ++ SN + A K QEE+ H +K Q++ +D
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID--- 1791
Query: 979 ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1038
K + E D+LS + S ++++ QE + ++
Sbjct: 1792 ------------------KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 1039 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1098
TL+KD+ + +K EME +L KQ+KD S + KL EN
Sbjct: 1834 TLKKDVNETQ---KKVSEME--------QLKKQIKDQSLTLS-------KLEIENL---- 1871
Query: 1099 EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK-SMQRCYEKEQQTVTKLHQLLE 1157
NL QK H LE+++++ K + ++E LK + E Q+T + ++ +
Sbjct: 1872 ------NLAQKLHENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQETKARDLEIQQ 1924
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1217
K + + EH + + +++ + + +++ +E+ K E+Q K+ L+
Sbjct: 1925 ELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQL 1982
Query: 1218 LETREVVDLSKYKATKSD-LETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEI 1269
L +E V++S K + + L+ Q + N + + L +K E EE+ I
Sbjct: 1983 LRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI------RI 2036
Query: 1270 SAKDEKELLHFSIEQEIKDQKERCDKSLTTITEL------QRRIQESAKQIEAKDNKITE 1323
AK+ EL I++ +K ++ D+ + T+ E+ +++ + + +TE
Sbjct: 2037 VAKERDELRR--IKESLKMER---DQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE 2091
Query: 1324 LLND-VERLKQALNGLSQL 1341
L + R+K+ L S++
Sbjct: 2092 SLREKCSRIKELLKRYSEM 2110
Score = 175 bits (444), Expect = 2e-43
Identities = 263/1269 (20%), Positives = 541/1269 (42%), Gaps = 183/1269 (14%)
Query: 276 NLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 335
NL +++ + + E + + +++ + ER K QE + L+ +++ L+ +
Sbjct: 509 NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ-LIHEISNLKNLVKHAE 567
Query: 336 MVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDML 395
+ DLE+E LL KE Q +K +Y +S L + + + +
Sbjct: 568 VYNQDLENELSSKVELLREKEDQ----------IKKLQEYIDSQKLENIKMDLSYSLESI 617
Query: 396 LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ-----TSYSENEILKKELEAMR 450
QM + + A +S + LR L L + T+Y + E +++ +
Sbjct: 618 EDPKQMKQTLFDAETVALDAKRES-AFLRSENLELKEKMKELATTYKQME---NDIQLYQ 673
Query: 451 TFCESAKQDRLKLQNELAHKVAEC-KALALECERVKEDSDEQIKQLEDALKDVQKRMYES 509
+ E+ K+ ++ L+ EL E K +L +V +D + +LE + D+QK + +
Sbjct: 674 SQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL-ELEGKITDLQKELNKE 732
Query: 510 EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
+ + ++ + L E S RL +E++D+ ++L + ++E KL +++
Sbjct: 733 VEENEALREEVILLSE--LKSLPSEVERLRKEIQDKSEELHI----ITSEKDKLFSEVVH 786
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEME-----------REKKGRKVTEMEGQAKE 618
E V+ + GK ++ Q + E +K + E E +E
Sbjct: 787 KESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Query: 619 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 678
+ + LS A+KF++ +L E++ K ++L E RE ++ L+E+ QLK +LEN + L
Sbjct: 847 I---VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTL 903
Query: 679 AQHVKPEEH----------EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 728
Q V+ E+ E+VK+ L Q+ +L + L ++ L+ +I N
Sbjct: 904 -QTVEREKTLITEKLQQTLEEVKT-LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 729 LKEQAHNLTIEMKNHYVPL-----KVSEDMKKS--------------------------- 756
+EQ N +K H + K+SE++ ++
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 757 ------------HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV-SRLETVF 803
D I + RK+ + Q+ E + +E ++ E + L D+ +E
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081
Query: 804 VPPE---------KHEKEIIALKSNIVELKK--------QLSELKKKCGEDQEKIHALTS 846
E K ++EI+A + N K+ +L+E+++K E +++
Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ 1141
Query: 847 ENTNLKKMMSNQYVPVKTHEEVKMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDK 903
+ N+++ MS + E +K L + TL E L++ +K + +E I +
Sbjct: 1142 QLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE 1201
Query: 904 NEILK-----------------RNLE----NTQNQIKAEYISLAEHEAKMSSLSQSMRKV 942
++LK R +E T+ ++K +I L EH+ ++ + R V
Sbjct: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ---ETIDELRRSV 1258
Query: 943 QDSNAEIL------ANYRKGQEEIVTLH--AEIKAQKKELDTIQECIKVKYAPIVSFEEC 994
+ A+I+ ++ K QEEI LH E+ KE+ QE + + E+
Sbjct: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE---LLTEQS 1315
Query: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK--KEIFTLQKDLRDKTVLIE 1052
K T ++ + +K+ S+EE+K +E D LK KE ++ D + K + E
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD-QLKEHIRE 1374
Query: 1053 KSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENA---KQTSEILAVQNLLQK 1109
+++ + S++ LN + KD + T++ + E+ +++ + E+L + LQ+
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKD--NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432
Query: 1110 QHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1162
H ++ V + L++ L + LKE +K + + + ++ + H L+ Q+ +
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492
Query: 1163 SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE 1222
L +L KE E+ I+ L ++ QNK++E+ + + E N KQ + E +
Sbjct: 1493 INELRVNLSEKET---EISTIQKQLEAINDKLQNKIQEIYE-KEEQFNIKQISEVQE--K 1546
Query: 1223 VVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSI 1282
V +L ++K + ++ + S+ K+ L + +E EE+ + I K+E + + ++
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI----QIMIKEKEEMKRVQEAL 1602
Query: 1283 EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT 1342
+ E KE + + + E Q + + K N+ E + ++E LK+
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV--NETQEKMCEIEHLKEQFETQKLNL 1660
Query: 1343 YTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQ- 1401
R +Q++ +++S+ ++ D R +E + + R L + + D++
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDL-RSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 1402 EALLQIIQM 1410
+ L+I+ M
Sbjct: 1720 QEELKIVHM 1728
Score = 135 bits (340), Expect = 3e-31
Identities = 247/1231 (20%), Positives = 525/1231 (42%), Gaps = 198/1231 (16%)
Query: 287 KSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGL---QLQLNEEVMVADDLES 343
K Q H ++ + E +DL+ +Q E L + + + L+ EE+ VA
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 344 EREK----LKSLLAAKEKQHEESLRTIEALKNRFK-----YFESDHLGSGSHFSNRKEDM 394
E+E+ L+ L+ KE + + +EA+ ++ + +E + + S +E +
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 395 L-LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 453
LKQ + + I + M LEL+ Q S E +I+ KE E M+
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKM--------LELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 454 ESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLE-DALKDVQKRMYESEGK 512
E+ + +R +L+ VA ++KE +++ + L+ A+ + Q++M E E
Sbjct: 1600 EALQIERDQLKENTKEIVA----------KMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649
Query: 513 VKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEM 572
+Q +T L L E++ +E N RLT+ L + L++++ + E LR+ + ++
Sbjct: 1650 KEQFETQKLNL-ENIETE----NIRLTQILHENLEEMR----SVTKERDDLRSVEETLKV 1700
Query: 573 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEK 631
++ K + + I + Q+EL + M ++ + ++ G E + +++ + E
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 632 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR-----------QLKRELENVKAKLA- 679
+ + ++ E+ + +E ++++ ++R ++++LEN AKL
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 680 --QHVKPEEHEQVKSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLDNKLLKEQ 732
Q +K EH+ + L++ E KK++E+ +K+Q+L + K+ ++N L ++
Sbjct: 1821 KIQELKANEHQLIT--LKKDVNETQKKVSEMEQLKKQIKDQSLT--LSKLEIENLNLAQK 1876
Query: 733 AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-KLLDVTQKYTEKKLEMEKLLLENDS 791
H EMK+ +K +++++ + + L R +L + Q+ + LE+++ L
Sbjct: 1877 LHENLEEMKS---VMKERDNLRRVEETL--KLERDQLKESLQETKARDLEIQQELKTARM 1931
Query: 792 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL--TSENT 849
LSK+ ETV EK ++ I + +L K EL+KK E Q+K L E+
Sbjct: 1932 LSKE--HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 850 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI--L 907
N+ N+ +K E + ++ N +L KK E + + + K+++E+ +
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL--TKKLHESLEEIRIVAKERDELRRI 2047
Query: 908 KRNLENTQNQIKAEYISLA-----EHEAK---------MSSLSQSMRKVQDSNAEILANY 953
K +L+ ++Q A + H+ K L++S+R+ E+L Y
Sbjct: 2048 KESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRY 2107
Query: 954 RKGQEEI-------VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE-------CERKFK 999
+ + + L EI+ QK+ ++ + + Y E+ C +F
Sbjct: 2108 SEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFH 2167
Query: 1000 ATEKELKDQLS-----EQTQKYSVSE------EEVKKNK----------QENDKLKKEIF 1038
K+LK LS ++ Q S+++ +EV+K K Q+ D +E+
Sbjct: 2168 RIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELR 2227
Query: 1039 TLQ----KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK---EKLVE 1091
L+ DL + +L + S ++ + ++ K+++Q E N + EKL
Sbjct: 2228 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287
Query: 1092 ENAKQTSEILAVQNLLQKQHVPL--------EQVEALKKSLNGTIENLKEELKSMQRCYE 1143
K+ I V N + + + E+ + K +++LKE+ + + + Y+
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
Query: 1144 KEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1203
+ ++ Q+ +++ P + EK + ++ SL E +E + +K ++ K
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK-IRELENSLHEAKESAMHKESKIIK 2406
Query: 1204 LQSEVQ---------------------NTKQALKKLETREVVDLSKYKATKSDLETQISS 1242
+Q E++ TK+ ++ L+ + + YK DL+ ++
Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK 2466
Query: 1243 LN-EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTIT 1301
++ EK+ N +E+ + + + +KE++ E + Q+ + ++ T
Sbjct: 2467 IDLEKMKNAKEFEKEI-------SATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHT 2519
Query: 1302 ELQ-----------RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1350
+ Q I ++ K + K I L ++ +LKQ L K
Sbjct: 2520 DPQPSNKPLTCGGGSGIVQNTKALILKSEHI-RLEKEISKLKQQNEQL----------IK 2568
Query: 1351 RQSQLIDTLQH---QVKSLEQQLADADRQHQ 1378
++++L+ QH +VK+ +++ + Q
Sbjct: 2569 QKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599
Score = 110 bits (274), Expect = 1e-23
Identities = 188/1043 (18%), Positives = 437/1043 (41%), Gaps = 113/1043 (10%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-----QNIQDLEIEN 303
+ L + EN + R + K+ L+ T + +K + RE + ++L+I +
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727
Query: 304 EDLKERLRKIQQEQRILLDKVNGLQ-----LQLNEEVMVADDLESEREKLKSLLAAKEKQ 358
LKE I + + I+ +K N + L+ + + + A DL+ + E + + KE+Q
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787
Query: 359 HE-ESLRTIEALK-NRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 416
+ LR I + K ++ + D S + + +++ + Q+
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE------ 1841
Query: 417 MQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKA 476
+Q SE E LKK+++ + + L L +L + E K+
Sbjct: 1842 ---------------TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
Query: 477 LALECE---RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 533
+ E + RV+E + QL+++L++ + R E + ++++T + KEH E
Sbjct: 1887 VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ---QELKTARMLSKEH--KETVD 1941
Query: 534 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEG---KLIEENKR 590
E Q+ D++ + + E+ K ++++ E+ + K D K I E ++
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001
Query: 591 LQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL-SIPAEKFENMKSSLSNEVNEKAKK 649
L+K+ + + ++ + E ++ + + ++ +K SL E ++
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIAT 2061
Query: 650 LVEM---EREHEKSLSEIR-----------QLKRELENVKAKLAQHVKPEEHEQVKSRLE 695
L EM +R++ + E R L+ + +K L ++ + ++H + +RL
Sbjct: 2062 LREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLS 2121
Query: 696 ---QKSGELGKKITELTLKNQTLQ----KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK 748
+K E K+++ N +L K IEK++ N+ + H + ++K YV
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLK--YVLSY 2179
Query: 749 VSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEK 808
V++ ++ H++I + +D +K E ++++ L + D S+++ L+ + +
Sbjct: 2180 VTKIKEEQHESI-NKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-LNQNMDL 2237
Query: 809 HEKEIIA--LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 866
H +EI+ +S +K + ++ E + + + +++K+ +
Sbjct: 2238 HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297
Query: 867 EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK----IKDKNEILKRNLENTQNQIK--A 920
+V N+ + E + +++ I++E+ + +K+KNE L +N + + + A
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGA 2357
Query: 921 EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 980
+ + S++ + + E+ + + +E + ++I +KEL+ +
Sbjct: 2358 QVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417
Query: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKN--KQENDKLKKEIF 1038
I A + +C K K T + L+D+++ + Y E++K K + +K+K
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKN--- 2474
Query: 1039 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1098
K E E + ++ T E K++ ++ ++E L Q +
Sbjct: 2475 -------------AKEFEKEISATKATVEYQKEV---------IRLLRENLRRSQQAQDT 2512
Query: 1099 EILAVQNLLQKQHVPL-----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1153
+++ Q + PL + K+L E+++ E K + + ++ +Q + + +
Sbjct: 2513 SVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE-KEISKLKQQNEQLIKQKN 2571
Query: 1154 QLLENQKNSS--VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNT 1211
+LL N ++ S V + +K K+V + K + +K ++++ Q + +N
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNL 2631
Query: 1212 KQALKKLETREVVDLSKYKATKS 1234
+ + K + S+ K+ S
Sbjct: 2632 QDPVPKESPKSCFFDSRSKSLPS 2654
Score = 93.2 bits (230), Expect = 2e-18
Identities = 158/826 (19%), Positives = 342/826 (41%), Gaps = 124/826 (15%)
Query: 673 NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK---NQTLQKEIEKVYLDNKLL 729
N K ++ + P ++ + L+ S K T + ++ L K K +D L
Sbjct: 299 NAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD---L 355
Query: 730 KEQAHNLTIEM------KNHYVPLKVSEDM-KKSHDAIIDDLNRKLLDVTQKYTEKKLEM 782
K+Q +++E K+ L +D+ +K + I++L R L+ + +++L+
Sbjct: 356 KKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKA 415
Query: 783 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 842
++ L K +++++ + + I K++ + + + C E +
Sbjct: 416 KRKRRVTWCLGK-INKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSN 474
Query: 843 ALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD 902
L + L ++ N + E ++ LN A + +LD ++ + + +K+K+
Sbjct: 475 TLDT----LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE 530
Query: 903 KN----------------------------------EILKRNLEN-----------TQNQ 917
KN E+ ++LEN ++Q
Sbjct: 531 KNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQ 590
Query: 918 IK--AEYISLAEHEAKMSSLSQSMRKVQDS--------NAEILANYRKGQEEIV-TLHAE 966
IK EYI + E LS S+ ++D +AE +A K + + + + E
Sbjct: 591 IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE 650
Query: 967 IKAQKKELDTIQECIKVKYAPIVSFEECERKFKA-TEKELKDQLSEQTQKYSVSEEEVKK 1025
+K + KEL T + ++ S E ++K + EKEL+ +E T+ S+ + +V K
Sbjct: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK 710
Query: 1026 NKQENDKLKKEIFTLQKD----------LRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
+ N +L+ +I LQK+ LR++ +L+ + ++L + + L K+++D
Sbjct: 711 DLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL----KSLPSEVERLRKEIQDK 766
Query: 1076 SQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1135
S++ + + K+KL E + S + + + K L ++ KS + +N K
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826
Query: 1136 KSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQ 1195
++ Y+ + +++Q + N + L A + E+ L+EK E Q
Sbjct: 827 MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL---GALKTELSYKTQELQEKTREVQ 883
Query: 1196 NKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLET------QISSLNEKL-- 1247
++ E+ +L+ +++N L+ +E + + K + T +++T + L E L
Sbjct: 884 ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 1248 ------------ANLNRKYEEVCEEVLHAKKKE------ISAKDEKEL-LHFSIEQEIKD 1288
N+N +E L + K+ + +K +E+ + +E+ +
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 1289 QKERCDKSLTTITELQRRIQESAKQIEA--KDNKITELLNDVERLKQALNGLSQ-LTYTS 1345
K+ + + I + Q ++ + + A KDN+I E + L Q N L Q L
Sbjct: 1004 TKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVI 1063
Query: 1346 GNPTKRQSQLIDTLQHQVKSLEQ--QLADADRQHQEVIAIYRTHLL 1389
+ ++ L + ++ +++ E+ L D ++ QE++A + H +
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAI 1109
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 177 bits (449), Expect = 6e-44
Identities = 234/1021 (22%), Positives = 459/1021 (44%), Gaps = 159/1021 (15%)
Query: 459 DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 517
+RL+ + E+ + VA+ + L +C +K D D+ LE L V+K + +E KVK +
Sbjct: 928 ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD----LELTLTKVEKEKHATENKVKNLS 983
Query: 518 THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVK--------------------YEGAS 557
AL+E++ S+ L E + L DL+V+ EG+
Sbjct: 984 EEMTALEENI-SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 558 AEVGKLR-----------NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
+ KLR +K ++ + + + D+ ++ E+ K+ + ELS + + + +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102
Query: 607 RKVTEMEGQAKELSAK---LALSIPAE-----KFENMKSSLSNEVNEKAKKL-------- 650
+ + + KEL A+ L I AE K E +S L+ E+ E +++L
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATS 1162
Query: 651 --VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG----ELGKK 704
+EM ++ E +E ++++R+LE +HE + L +K ELG++
Sbjct: 1163 AQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAATLRKKQADSVAELGEQ 1210
Query: 705 ITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 764
I L Q L+KE ++ ++ + L+ N + ED ++
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ-------FSEI 1263
Query: 765 NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 824
K TQ + ++ +L +N LS V E++ K ++ AL + ELK
Sbjct: 1264 KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ---ALTQQLEELK 1320
Query: 825 KQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 884
+Q+ E K HAL S + ++ QY + +E K L L+K N E+
Sbjct: 1321 RQMEEETKA---KNAMAHALQSSRHDCD-LLREQY---EEEQEAKAELQRALSKANSEVA 1373
Query: 885 DVKKKFE-DINQEFVKIKD-KNEILKR----------------NLENTQNQIKAEYISLA 926
+ K+E D Q ++++ K ++ +R +LE T+ +++ E L
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 927 EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKY 985
+ + ++ K Q + ++LA +++ +E AE++A +KE ++ E K++
Sbjct: 1434 RDLERSHTACATLDKKQRNFDKVLAEWKQKLDES---QAELEAAQKESRSLSTELFKMRN 1490
Query: 986 APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLR 1045
A ++ E + K L++++S+ T++ + E KN QE +K KK + + DL+
Sbjct: 1491 AYEEVVDQLET-LRRENKNLQEEISDLTEQIA----ETGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 1046 DKTVLIEKSHEMERA-LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQ 1104
+E S E E + + R EL++ +L +K E E+L + N+++ +E A+Q
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQL-KRNSQRAAE--ALQ 1602
Query: 1105 NLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV 1164
++L + LKK + G + ++ +L R + Q+ + + L K+S +
Sbjct: 1603 SVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL---KDSQL 1659
Query: 1165 PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1224
L + L+ E ++++ I+ E + +EE+ +++ ++ T++ ++L +E++
Sbjct: 1660 HLDDALRSNEDLKEQLAIV-------ERRNGLLLEELEEMKVALEQTERT-RRLSEQELL 1711
Query: 1225 DLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF 1280
D S T + + +KL A + E +E +A++K A + ++
Sbjct: 1712 DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE 1771
Query: 1281 SI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITELLNDVE 1329
+ EQ+ ER K+L T+ +LQ R+ E+ KQI+ +N++ EL N+++
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD 1831
Query: 1330 ----RLKQALNG-------LSQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQLADADR 1375
R +AL G + ++TY + K R L+D LQ +VKS ++Q +A+
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 1376 Q 1376
Q
Sbjct: 1892 Q 1892
Score = 142 bits (357), Expect = 3e-33
Identities = 197/919 (21%), Positives = 401/919 (43%), Gaps = 141/919 (15%)
Query: 508 ESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQI 567
E+E ++ M+ F KE L A + K+L+ K E L+ Q+
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEA------------RRKELEEKMVSLLQEKNDLQLQV 895
Query: 568 K-QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 626
+ + E +++ +R EG L ++ E K +++TE + +E++++L
Sbjct: 896 QSETENLMDAEERCEG------------LIKSKILLEAKVKELTERLEEEEEMNSELVAK 943
Query: 627 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-- 684
E+ SSL ++++ L ++E+E + ++++ L E+ ++ +++ K
Sbjct: 944 --KRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001
Query: 685 ---EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 741
E H+Q L+ + K+ L N L+++ + L+ L +E+ +E
Sbjct: 1002 SLQEAHQQTLDDLQVEED----KVNGLIKINAKLEQQTDD--LEGSLEQEKKLRADLERA 1055
Query: 742 NHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS-------LSK 794
K+ D+K S ++I+D N K + +K +K+ E+ +L + D K
Sbjct: 1056 KR----KLEGDLKMSQESIMDLENDKQ-QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK 1110
Query: 795 DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNL 851
+ L+ E+ E+EI A + +++KQ S+L ++ E E++ TS +
Sbjct: 1111 KIKELQARI---EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167
Query: 852 KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL 911
K ++ ++ E ++ A T ++KK D E + D + +K+ L
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAAT------LRKKQADSVAELGEQIDNLQRVKQKL 1221
Query: 912 ENTQNQIKAEYISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 967
E ++++K E +A + S++ ++ R V+D +EI A K +++ +H ++
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA---KDEQQTQLIH-DL 1277
Query: 968 KAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKN 1026
QK L T + E + EKE L QL++ Q + EE+K+
Sbjct: 1278 NMQKARLQT---------------QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Query: 1027 KQENDKLKKEI-FTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKY-TE 1081
+E K K + LQ D +L E+ E + A L R + N ++ KY T+
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 1082 VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK----- 1136
E+L E K + + + + +E K+ L G +E+L +L+
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 1137 -----SMQRCYEK-----EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKAS 1186
QR ++K +Q+ +L QK S E +++ A+E+ V ++
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 1187 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLE-TREVVDLSKYKATKSDLETQISSLNE 1245
RE ++N EE+S L ++ T + L++ E T+++V+ K SDL+ +
Sbjct: 1503 RRE----NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK-----SDLQVAL----- 1548
Query: 1246 KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQR 1305
EEV + H + K + + E + +++++ ++ E I +L+R
Sbjct: 1549 ---------EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE-------IEQLKR 1592
Query: 1306 RIQESAKQIEAKDNKITELLNDVERLKQALNG-LSQLTYTSGNPTKRQSQL---IDTLQH 1361
Q +A+ +++ + ND RLK+ + G L+++ G+ ++ ++ + T+Q
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Query: 1362 QVKSLEQQLADADRQHQEV 1380
Q+K + L DA R ++++
Sbjct: 1653 QLKDSQLHLDDALRSNEDL 1671
Score = 137 bits (345), Expect = 7e-32
Identities = 226/1121 (20%), Positives = 450/1121 (40%), Gaps = 181/1121 (16%)
Query: 297 QDLEIENEDL---KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESERE---KLKS 350
+D E E+L + R ++++++ LL + N LQLQ+ E D E E K K
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 351 LLAAKEKQHEESL-------------------------RTIEALKNRFKYFESDHLGSGS 385
LL AK K+ E L R I+ L+ E + + +
Sbjct: 918 LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN 977
Query: 386 HFSNRKEDM---------LLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSY 436
N E+M L K+ + Q T + + L + L QT
Sbjct: 978 KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKED---SDEQIK 493
E + ++ + +R E AK+ KL+ +L L + ++++E + ++
Sbjct: 1038 LEGSL--EQEKKLRADLERAKR---KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 494 QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 553
QL+ + D Q + + K+K++Q L+E + +E H L +++ Q DL +
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-----HTLRAKIEKQRSDLAREL 1147
Query: 554 EGASAEV----GKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 609
E S + G QI+ N+ EF++ L E LQ E + + R+K+ V
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATL-RKKQADSV 1204
Query: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
E+ Q L +K E KS L E+++ A + + + R ++
Sbjct: 1205 AELGEQIDNLQRV------KQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 670 ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITE-------LTLKNQTLQKEIEK 721
+ +KAK Q + + K+RL+ ++GEL ++ E LT Q L +++E+
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318
Query: 722 V--YLDNKLLKEQAHNLTIEMKNHYVPL-----KVSEDMKKSHDAIIDDLNRKLLDVTQK 774
+ ++ + + A ++ H L + ++ K + N ++ K
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Query: 775 Y-------TEKKLEMEKLLLEN---------------DSLSKDVSRL----ETVFVPPEK 808
Y TE+ E +K L + SL K RL E + E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 809 HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---MMSNQYVPV--- 862
L K L+E K+K E Q ++ A E+ +L M N Y V
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498
Query: 863 --------KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 914
K +E L + +A+T + L + +K + + QE ++ E ++ +LE+
Sbjct: 1499 LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
Query: 915 QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 974
+++I + L++ ++++ RKV + + EI R Q L + + A E+
Sbjct: 1559 ESKILRVQLELSQVKSELD------RKVIEKDEEIEQLKRNSQRAAEALQSVLDA---EI 1609
Query: 975 DTIQECIKVKYAPIVSFEECE-------RKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1027
+ + +++K E E R+ T+K L+ + ++ ++ N+
Sbjct: 1610 RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669
Query: 1028 QENDKL---KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1084
++L ++ L ++L + V +E++ R ++ + + +++ L + T + N
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLIN 1729
Query: 1085 VKEKL--------------------VEENAKQT-SEILAVQNLLQKQHVPLEQVEALKKS 1123
K+KL EE AK+ ++ + L+K+ +E +KK+
Sbjct: 1730 TKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 1124 LNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1175
L T+++L+ LK ++ +K + V +L L+ ++ AE L+
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRG---AEALKGAHK 1846
Query: 1176 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1235
+E++V + E + + V KLQ++V++ K+ ++ E + LS+ + + +
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE 1906
Query: 1236 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1276
LE + + +N+ L AK +++ ++ +E
Sbjct: 1907 LEEAAERADIAESQVNK---------LRAKSRDVGSQKMEE 1938
Score = 121 bits (303), Expect = 5e-27
Identities = 206/1004 (20%), Positives = 415/1004 (41%), Gaps = 155/1004 (15%)
Query: 546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKK 605
L+ +++ +G + + L KQ I+ EG+ I+ +K L+ +++RE+
Sbjct: 703 LEGIRICRKGFPSRI--LYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQF 760
Query: 606 GRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE-----VNEKAKKLVE-------- 652
T++ +A L L + EK + +S + + KK++E
Sbjct: 761 RFGNTKVFFKAGLLG--LLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCI 818
Query: 653 -------MEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK---SRLEQKSGELG 702
M +H ++ ++K L++ +A+ E+ E+ K +R E + EL
Sbjct: 819 QYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELE 878
Query: 703 KKITELTLKNQTLQKEIE-------------------KVYLDNKLLKEQAHNL--TIEMK 741
+K+ L + LQ +++ K+ L+ K +KE L EM
Sbjct: 879 EKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK-VKELTERLEEEEEMN 937
Query: 742 NHYVPLKVS-EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL- 799
+ V K + ED S IDDL L V ++ + +++ L E +L +++S+L
Sbjct: 938 SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT 997
Query: 800 ----------ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 849
+ + E ++ L +L++Q +L+ ++++ L
Sbjct: 998 KEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057
Query: 850 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKR 909
L+ + + E K + + L K EL ++ K +D ++ + K + L+
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 910 NLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQD--------SNAEILANYRKGQE--- 958
+E + +I+AE+ A+ E + S L++ + ++ + ++A+I N ++ E
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 959 -----EIVTLHAEIKA---QKKELDTIQEC--------------------IKVKYAPIVS 990
E TL E A +KK+ D++ E +K++ + S
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 991 FEECERKFKA----TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1046
E K K+ T + ++DQ SE K + + + +L+ + L + +
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 1047 KTVLIEKSHEMERALSRKTDELNKQLKD---------------------LSQKYTEVKNV 1085
K LI + + ++AL+++ +EL +Q+++ L ++Y E +
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 1086 KEKLVEENAKQTSEILAVQNLLQKQHVP-LEQVEALKKSLNGTIENLKEELKSM-QRCYE 1143
K +L +K SE+ + + + E++E KK L ++ +E ++ +C
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417
Query: 1144 KE---QQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1200
E Q+ ++ L+ + + S A + + F+K + K L E + E + +E
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 1201 VSKLQSEVQNTKQALKKLETREVVD-LSKYKATKSDLETQISSLNEKLANLNRKYEEVCE 1259
L +E+ + A + EVVD L + +L+ +IS L E++A + +E
Sbjct: 1478 SRSLSTELFKMRNAYE-----EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE--- 1529
Query: 1260 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDN 1319
A+K + + EK L ++E+ + K L EL + E +++ KD
Sbjct: 1530 ----AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 1320 KITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1379
+I +L + +R +AL + S N R L ++ + +E QL ++RQ E
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALR---LKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 1380 VIAIYRT--HLLSAAQGHMD------EDVQEALLQIIQMRQGLV 1415
RT L +Q H+D ED++E L I++ R GL+
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ-LAIVERRNGLL 1685
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 176 bits (447), Expect = 1e-43
Identities = 226/1045 (21%), Positives = 456/1045 (43%), Gaps = 163/1045 (15%)
Query: 459 DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 517
+RL+ + E+ A A+ + L EC +K D D+ LE L V+K + +E KVK +
Sbjct: 924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDD----LELTLAKVEKEKHATENKVKNLT 979
Query: 518 THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS----AEVGKLRNQIKQNEMI 573
L E + ++ L E + L DL+ + + + A+V KL Q+ E
Sbjct: 980 EEMAGLDE-IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV-KLEQQVDDLEGS 1037
Query: 574 VEEFKRDEGKLIEENKRLQKEL-----SMCEMEREKKG---------------------- 606
+E+ K+ L ++L+ +L S+ ++E +K+
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Query: 607 --------RKVTEMEGQAKELSAKLALSIPAE-KFENMKSSLSNEVNEKAKKL------- 650
+K+ E++ + +EL +L A K E ++S LS E+ E +++L
Sbjct: 1098 QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1157
Query: 651 ---VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG----ELGK 703
+EM ++ E +E ++++R+LE +HE + L +K ELG+
Sbjct: 1158 SVQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAAALRKKHADSVAELGE 1205
Query: 704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDD 763
+I L Q L+KE + L+ + + N + ED H + ++
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265
Query: 764 LNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 823
R + D+T + KL EN LS+ + E + + + + + +L
Sbjct: 1266 TQRSVNDLTS-------QRAKLQTENGELSRQLDEKEALISQLTRGK---LTYTQQLEDL 1315
Query: 824 KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 883
K+QL E K HAL S + ++ QY + E K L L+K N E+
Sbjct: 1316 KRQLEEEVKA---KNALAHALQSARHDCD-LLREQY---EEETEAKAELQRVLSKANSEV 1368
Query: 884 LDVKKKFE-DINQEFVKIKD-KNEILKR----------------NLENTQNQIKAEYISL 925
+ K+E D Q ++++ K ++ +R +LE T+++++ E L
Sbjct: 1369 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428
Query: 926 AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVK 984
+ ++ + ++ K Q + +ILA +++ EE +E+++ +KE ++ E K+K
Sbjct: 1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLK 1485
Query: 985 YAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL 1044
A S E E FK K L++++S+ T++ S + + + ++ +L+ E LQ L
Sbjct: 1486 NAYEESLEHLET-FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 1045 RDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIL-AV 1103
+ +E HE E + R E N+ ++ +K E K++ +E+ + ++ ++
Sbjct: 1545 EEAEASLE--HE-EGKILRAQLEFNQIKAEIERKLAE----KDEEMEQAKRNHLRVVDSL 1597
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
Q L + + +KK + G + ++ +L R + Q+ V L LL K++
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL---KDTQ 1654
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
+ L + ++ + ++ + I+ E + E+ +L++ V+ T+++ +KL +E+
Sbjct: 1655 IQLDDAVRANDDLKENIAIV-------ERRNNLLQAELEELRAVVEQTERS-RKLAEQEL 1706
Query: 1224 VDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK-------------- 1265
++ S+ + + L Q ++ L+ L + EE +E +A+
Sbjct: 1707 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766
Query: 1266 ---KKEISAKDEKELLHFSIEQEIKDQKERCDKS--------LTTITELQRRIQESAKQI 1314
KKE E + ++EQ IKD + R D++ + +L+ R++E ++
Sbjct: 1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL 1826
Query: 1315 EAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADAD 1374
EA+ + E + + + ++ + L+ T R L+D LQ +VK+ ++Q +A+
Sbjct: 1827 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1886
Query: 1375 RQHQEVIAIYR--THLLSAAQGHMD 1397
Q ++ +R H L A+ D
Sbjct: 1887 EQANTNLSKFRKVQHELDEAEERAD 1911
Score = 149 bits (377), Expect = 1e-35
Identities = 219/1011 (21%), Positives = 416/1011 (41%), Gaps = 127/1011 (12%)
Query: 475 KALALECERVKEDSD--EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA 532
K L ER KE + E+ +L++AL+ + R E E K+ + L+ L +A
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ--LQVQAE 894
Query: 533 SGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 592
N EE DQL K++ E A+V ++ +++ E + E + KL +E L+
Sbjct: 895 QDNLADAEERCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 593 K-----ELSMCEMEREK-----KGRKVTEMEGQAKELSAKLALSIPA--EKFENMKSSLS 640
+ EL++ ++E+EK K + +TE E+ AKL A E + L
Sbjct: 952 RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011
Query: 641 NE---VNEKAKKLVEMEREH---EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 694
E VN K V++E++ E SL + ++++ +LE K KL +K + + L
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD--L 1069
Query: 695 EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 754
E +L +++ + + L IE L+++ L ++ L+ +
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 755 KSHDAIIDDLNRKLLDVTQKYTE------------KKLEMEKLLLENDSLSKDVSRLETV 802
+ + DL+R+L +++++ E KK E E + D + T
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Query: 803 FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 862
+KH + L I L++ +L+K+ E + ++ +TS + K +N
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL---- 1245
Query: 863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 922
E++ TL D + + + + ++ D+ + K++ +N L R L+ + I
Sbjct: 1246 ---EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Query: 923 ISLAEHEAKMSSLSQSMR---KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQE 979
+ ++ L + + K +++ A L + R + + + E K EL +
Sbjct: 1303 RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362
Query: 980 CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1039
+ A + E + + TE EL++ + Q+ +EE V+ + L+K
Sbjct: 1363 KANSEVAQWRTKYETDA-IQRTE-ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ ++ D V +E+S+ AL +K +K L + QKY E ++ E +E ++E
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 1100 ILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1159
+ ++N ++ LE +E K+ +NL+EE+ + +T+ +L ++ +
Sbjct: 1481 LFKLKNAYEES---LEHLETFKRE----NKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Query: 1160 KNSSVPLAEHLQIKEA-----------FEKEVGIIKASLREKEEESQNKMEEVSK----- 1203
+ + L L+ EA + E IKA + K E +ME+ +
Sbjct: 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593
Query: 1204 -------LQSEVQNTKQAL---KKLE---TREVVDLSKYKATKSDLETQISSLNEKLAN- 1249
L +E ++ +AL KK+E + LS ++ + Q+ SL L +
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653
Query: 1250 ---------------------------LNRKYEE---VCEEVLHAKK---KEISAKDEKE 1276
L + EE V E+ ++K +E+ E+
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713
Query: 1277 LLHFSIEQEIKDQKERCDKSLTTI-TELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335
L S + +QK++ D L+ + TE++ +QE E IT+ E LK+
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773
Query: 1336 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ-QLADADRQHQEVIAIYR 1385
+ + L K Q I LQH++ EQ L +Q Q++ A R
Sbjct: 1774 DTSAHLE----RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820
Score = 142 bits (358), Expect = 2e-33
Identities = 228/1069 (21%), Positives = 457/1069 (42%), Gaps = 165/1069 (15%)
Query: 280 MQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN--EEVMV 337
M E+ K + E + +L+ + +DL+ L K+++E+ +KV L ++ +E++
Sbjct: 932 MNAELTAKKRKLEDE-CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990
Query: 338 A----------------DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHL 381
DDL++E +K+ +L AK K E+ + +E + K D
Sbjct: 991 KLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL-EQQVDDLEGSLEQEKKVRMD-- 1047
Query: 382 GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSM-LRPL------ELSLPSQT 434
+ RK + LK Q + D + + ++ + L L E +L SQ
Sbjct: 1048 ---LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104
Query: 435 SYSENEI------LKKELEAMRTF---CESAKQDRLKLQNELAHKVAEC----------- 474
E+ L++ELEA RT E + D + E++ ++ E
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Query: 475 KALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASG 534
K E ++++ D +E Q E ++K+ +S ++ + + +K+ L E +
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 535 NHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 594
L + + + +K K L +Q+ ++ EE +R L + +LQ E
Sbjct: 1225 KLELDDVTSNMEQIIKAK-ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 595 LSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFENMKSSLSNEVNEK------- 646
+ R++ E E +L+ KL + ++ E++K L EV K
Sbjct: 1284 -------NGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKRQLEEEVKAKNALAHAL 1333
Query: 647 --AKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGK 703
A+ ++ RE + +E + +L+R L +++AQ E + + Q++ EL +
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI-----QRTEELEE 1388
Query: 704 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDD 763
+L + Q ++ +E V L++ H L E+++ V ++ S + D +
Sbjct: 1389 AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1448
Query: 764 LNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 823
++ L + QKY E + E+E E SLS ++ +L+ + E+ + + K L
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY---EESLEHLETFKRENKNL 1505
Query: 824 KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 883
++++S+L ++ G + IH L L E KM L L + L
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQL--------------EAEKMELQSALEEAEASL 1551
Query: 884 LDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI-SLAEHEAKMSSLSQSMRKV 942
++ +IL+ LE NQIKAE LAE + +M ++ +V
Sbjct: 1552 EH----------------EEGKILRAQLEF--NQIKAEIERKLAEKDEEMEQAKRNHLRV 1593
Query: 943 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATE 1002
DS L + + E + + +++ E++ I++ +A ++ E +++ K+ +
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEME-----IQLSHANRMA-AEAQKQVKSLQ 1647
Query: 1003 KELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--------KTVLI 1051
LKD QL + + +E + ++ N+ L+ E+ L+ + + LI
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Query: 1052 EKSHEMERALSRKTDELNKQLK---DLSQKYTEVKNVKEKL--VEENAKQT-SEILAVQN 1105
E S ++ S+ T +N++ K DLSQ TEV+ ++ EE AK+ ++ +
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767
Query: 1106 LLQKQHVPLEQVEALKKSLNGTIENLKEEL--------KSMQRCYEKEQQTVTKLHQLLE 1157
L+K+ +E +KK++ TI++L+ L K ++ +K + V +L LE
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827
Query: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQA 1214
++ + + ++ E KE+ + EE+ +N + + V KLQ +V+ K+
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTY------QTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1881
Query: 1215 LKKLETREVVDLSKYKATKSDL----------ETQISSLNEKLANLNRK 1253
++ E + +LSK++ + +L E+Q++ L K ++ K
Sbjct: 1882 AEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Score = 115 bits (287), Expect = 4e-25
Identities = 178/884 (20%), Positives = 369/884 (41%), Gaps = 93/884 (10%)
Query: 563 LRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK 622
L +Q I+ EG+ I+ K +K LS +++ + G K
Sbjct: 714 LYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQY------KFGHTKVFFKA 767
Query: 623 LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHV 682
L + E + S + + +++ ++ E++K L L N++A +
Sbjct: 768 GLLGLLEEMRDERLSRIITRIQAQSRGVLA-RMEYKKLLERRDSLLVIQWNIRAFMGVKN 826
Query: 683 KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 742
P K + KS E K++ + + L++ +EK K L+E+ +L E +
Sbjct: 827 WPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND 886
Query: 743 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETV 802
+ ++ +D + D L + + + K E M + L + + ++ +++ +
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE----MNERLEDEEEMNAELTAKK-- 940
Query: 803 FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 862
K E E LK +I +L+ L++++K+ + K+ LT E L ++++
Sbjct: 941 ----RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA------ 990
Query: 863 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 922
K +E K L + +++ LD + ED K K K E +LE + Q K
Sbjct: 991 KLTKEKK-----ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVR 1045
Query: 923 ISLAEHEAKMSS----LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 978
+ L + K+ +S+ +++ ++ +K E+ L+A I+ ++ +Q
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Query: 979 ECIKVKYAPIVSFEE---CERKFKATEKELKDQLSEQTQKYSVSEEEV----KKNKQEND 1031
+ +K A I EE ER +A ++L+ LS + ++ S EE + N
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1165
Query: 1032 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVE 1091
K + E +++DL + T+ HE A RK + +L ++ ++ VK+KL +
Sbjct: 1166 KREAEFQKMRRDLEEATL----QHEATAAALRKKHA--DSVAELGEQIDNLQRVKQKLEK 1219
Query: 1092 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTK 1151
E ++ E+ V + +EQ+ K +L L++++ + E+ Q++V
Sbjct: 1220 EKSEFKLELDDVTS-------NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272
Query: 1152 LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNT 1211
L + + L+ L KEA ++ K + ++ E+ + ++EE K ++ + +
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 1212 KQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYE----EVCEEVLHAKKK 1267
Q+ + + K++L+ +S N ++A KYE + EE+ AKKK
Sbjct: 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392
Query: 1268 -------------EISAK-DEKELLHFSIEQEIKD---QKERCDKSLTTITELQR----- 1305
++AK E ++ EI+D ER + + + + QR
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 1306 ------RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1359
+ +ES ++E+ + L ++ +LK A + T KR+++ L
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET----FKRENK---NL 1505
Query: 1360 QHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEA 1403
Q ++ L +QL + + E+ + + L A + + ++EA
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQ--LEAEKMELQSALEEA 1547
Score = 110 bits (275), Expect = 1e-23
Identities = 175/852 (20%), Positives = 351/852 (41%), Gaps = 152/852 (17%)
Query: 258 NTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-QNIQDL--EIEN-EDLKERLRKI 313
N + E K L++ L H E + +++H ++ +L +I+N + +K++L K
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
Query: 314 QQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRF 373
+ E ++ LD V Q+ + +LE L+ + + EE+ R++ L ++
Sbjct: 1221 KSEFKLELDDVTSNMEQI---IKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR 1277
Query: 374 KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ 433
++++ G S + KE ++ SQ T + Q + R LE + ++
Sbjct: 1278 AKLQTEN-GELSRQLDEKEALI----------SQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326
Query: 434 TSYSEN-EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQI 492
+ + + + + + +R E + + +LQ L+ +E +A + + D+ ++
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE---VAQWRTKYETDAIQRT 1383
Query: 493 KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL--- 549
++LE+A K + +R+ E+E V+ + +L++ HRL E++D + D+
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT--------KHRLQNEIEDLMVDVERS 1435
Query: 550 ---------------------KVKYEGA--------------SAEVGKLRNQIKQNEMIV 574
K KYE + S E+ KL+N +++ +
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495
Query: 575 EEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN 634
E FKR ENK LQ+E+S + G+ + E+E K+L A+
Sbjct: 1496 ETFKR-------ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE------------ 1536
Query: 635 MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 694
K L + + E L E + ++ E Q+K E+E KLA+ K EE EQ K
Sbjct: 1537 -KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAE--KDEEMEQAKRNH 1590
Query: 695 EQKSGELGKKI-TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM 753
+ L + E +N+ L+ + K ++ + + I++ + ++
Sbjct: 1591 LRVVDSLQTSLDAETRSRNEALRVK--------KKMEGDLNEMEIQLSHANRMAAEAQKQ 1642
Query: 754 KKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEI 813
KS +++ D +L D + + K + + N+ L ++ L V E+ K
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK-- 1700
Query: 814 IALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNL---KKMMSNQYVPVKTH-EEVK 869
L+E ++ E E++ L S+NT+L KK M ++T EE
Sbjct: 1701 -------------LAE--QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1745
Query: 870 MTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK--------AE 921
+ K + + D E++ +E +D + L+R +N + IK AE
Sbjct: 1746 QECRNAEEKAKKAITDAAMMAEELKKE----QDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 922 YISLA-------EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 974
I+L + EA++ L + Q NAE + RK + I L + + +K L
Sbjct: 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL 1861
Query: 975 DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK 1034
+Q+ + + + +K +E ++Q + K+ + E+ + ++ D +
Sbjct: 1862 LRLQDLVDKLQLKV-------KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1914
Query: 1035 KEIFTLQKDLRD 1046
++ L+ RD
Sbjct: 1915 SQVNKLRAKSRD 1926
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 174 bits (440), Expect = 7e-43
Identities = 266/1267 (20%), Positives = 543/1267 (42%), Gaps = 232/1267 (18%)
Query: 271 SLQQRNLTHMQDEVNVKSHQRE-HQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQL 329
SL+Q+ + N+K + Q L E D+K + + + + KV L
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
Query: 330 QLNEEVMVADDLESE-------------REKLKSLLAAKEKQHEESLRTIEALKNRFKYF 376
+LN+E V DL++E +++L + + E R E LK+ K
Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 377 ESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSY 436
+S + S + S + + L +G +A ++Q L+ L +
Sbjct: 259 QSQYASSEATISQLRSE--LAKGPQEVA----------VYVQELQKLKSSVNELTQKNQT 306
Query: 437 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLE 496
+LKKE QD KL+ E+ E+S +
Sbjct: 307 LTENLLKKE------------QDYTKLE-----------------EKHNEESVSK----- 332
Query: 497 DALKDVQKRMYESEGKVKQMQTHFLALKE--HLTSEAASGNHRLTEELKDQLKDLKVKYE 554
K++Q +++ + +Q+Q+ A + H S T++LK++L +++ KY+
Sbjct: 333 ---KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQ 389
Query: 555 GASAEVGKLRNQIKQNE----MIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 610
AE +L+ Q ++ E + E + KL+E ++L + + +R+ K+
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 611 EMEGQAKELSAKLA-LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 669
+ E Q +L KL+ L ++ + L +++++ ++ E + + + +++R+ +
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
Query: 670 ELENV-------------------KAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTL 710
+LE V K+K + +E E + ++++ GE + +L
Sbjct: 510 DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA-VLNQLQE 568
Query: 711 KNQTLQKEI----EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR 766
KN TLQ+++ EK+ ++ K+ NL +++ L+ ++D S + +++LN
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 767 KLLDVTQKYTEKKLEME---KLLL--------------------------ENDSLSKDVS 797
+L + +K ++ ++++ +LLL + L+K +
Sbjct: 629 QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 798 RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 857
+L+ V + ++ L+S++ E K++ L++K E + +I L +++ +K
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 858 QYVPVKTHEEVKMTLNDTLAKTNREL-----------LDVKKK---FEDINQEFVKIKDK 903
++ ++ L + +++L LD++KK E I Q+ K +++
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 904 NEILKRNLENTQNQIKAEYISL---------------AEHEAKMSSLS---QSMRKVQD- 944
+ILK++ E + K ++ L E EA M+ LS + KV D
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 945 ---SNAEILANYRKGQEEIVTLHAEIKAQKKEL-----DTIQECIKVKYAPIVSFEECER 996
S +E +KG+ I+ L K K +L +T++E ++K + + +E
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS-LEKEKEASH 927
Query: 997 KFKATEKELKDQL--SEQTQKYSVSEEE-----VKKNKQENDKLKKEIFTLQKDLRDKTV 1049
+ K +++QL ++ T K + EE+ + + KQ +++ KK+I LQ +L K
Sbjct: 928 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL--KIA 985
Query: 1050 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ--------TSEIL 1101
+++K+ E+E L ++ + ++L +K + ++N EK +E KQ SE+L
Sbjct: 986 VLQKT-ELENKLQQQLTQAAQELAAEKEKISVLQNNYEK-SQETFKQLQSDFYGRESELL 1043
Query: 1102 AVQNLLQ--KQHVPLEQVEAL-KKSLNGTIENLKEELKSMQRCYE-----KEQQTVTKLH 1153
A + L+ ++ + L Q + + ++ G L +ELK+ + E KEQQ +
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 1154 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1213
L + QK S+ EKE+ K+ L E EE + +E++KL E+++
Sbjct: 1104 ALQDIQKEKSLK-----------EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS--- 1149
Query: 1214 ALKKLET-REVVDLSKYK----ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK--- 1265
KLE+ +E+ +L K K +L+ + SL + R + + ++V +
Sbjct: 1150 --HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Query: 1266 KKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
KKE K+ K LH I+++ +K +E K IT L + K+ ++ +++
Sbjct: 1208 KKEFIEKEAK--LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1265
Query: 1323 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL---------IDTLQHQVKSLEQQLADA 1373
EL + L+ + L N +R++ L I+ LQ +V L+++L +
Sbjct: 1266 ELEKQTDDLRGEIAVLE--ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT 1323
Query: 1374 DRQHQEV 1380
QE+
Sbjct: 1324 TAAVQEL 1330
Score = 169 bits (427), Expect = 2e-41
Identities = 220/1119 (19%), Positives = 495/1119 (44%), Gaps = 123/1119 (10%)
Query: 284 VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVN-------GLQLQLNEEVM 336
V V+ Q+ ++ +L +N+ L E L K +Q+ L +K N +Q L+++ +
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344
Query: 337 VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLL 396
L+S ++ L + E + LK E+ + + F ++
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 397 KQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE-----LEAMRT 451
K+ S+ +++ L L Q S +++ KE L+ +
Sbjct: 405 KEQHGLQLQSEINQLHSKL-LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
Query: 452 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 511
E ++++ EL H++ + K E + +++ + ++++ ++ L+ V +++ + +
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 512 KVKQMQTHFLALKEHLTS------------EAASGNHRLTEELKDQLKDLKVKYEGASAE 559
K++ ++ KE+++ +A G + +L+++ L+ E +
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ---EQVTQL 580
Query: 560 VGKLRNQIKQN----EMIVEEFKRDEGKL-IEENKRLQKELSMCEMERE--KKGRKVTEM 612
KL+NQ + + E + ++ + + L +++ L E S+ E+ + + KV+++
Sbjct: 581 TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640
Query: 613 EGQAKELSAKLALSIPAEKFEN-MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 671
+ Q K AK L + AE + ++ L N ++ L + ++E K +++ Q+ +L
Sbjct: 641 DIQIK---AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 672 ENVK---AKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 728
++ + ++L H+K E+++ LEQK+ EL +I +L + ++ E+ D +
Sbjct: 698 QDKQEHCSQLESHLK--EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 729 LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 788
++ +L + L++ +++ S + + L + QK T+++ E + L +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 789 NDSLSKDV--------SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 840
++LS++ +R++T +K + E AL + + +K +LS++ + +
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 841 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI 900
EN K + + KT +E+K L + T +E ++KK E K
Sbjct: 876 FE---KENQKGKAAILDLE---KTCKELKHQLQVQMENTLKEQKELKKSLE-------KE 922
Query: 901 KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 960
K+ + LK L + Q Q+ +L ++E + L ++ +++ S+ +
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ------------ 970
Query: 961 VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1020
+KK+++ +Q +K+ ++ E E K + + +L+ + +K SV +
Sbjct: 971 ---------KKKQIEALQGELKIA---VLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 1021 EEVKKNKQENDKLKKEIFTLQKDL----------RDKTVLIEKSHEMERALSRKTDELNK 1070
+K+++ +L+ + + + +L +K L ++ R ++L +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 1071 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHV----PLEQVEALKKSLNG 1126
+LK + KE+ ++E K +I ++L +K+ V L ++E +K
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 1127 TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKA 1185
I L EELKS + KE + QLL QK A+ L+ E ++ I+K
Sbjct: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD 1198
Query: 1186 SLREKEEESQNK-MEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
++++EEE + + +E+ +KL SE++ + +KK E E + L QI++LN
Sbjct: 1199 QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE-----------AKLTMQITALN 1247
Query: 1245 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTIT 1301
E L + ++++ V +K+ + E +L +++ +++ ERC K I
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 1302 ELQRRIQESAKQIEAKDNKITELLNDVERLK----QALN 1336
+LQ ++ E ++++ + EL + + L+ QALN
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 162 bits (409), Expect = 3e-39
Identities = 234/1124 (20%), Positives = 498/1124 (44%), Gaps = 177/1124 (15%)
Query: 340 DLESEREKLKSLLAAKEKQHE-----ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDM 394
DL+S + ++ E E + ++++ + FK++E+ H + ++
Sbjct: 19 DLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNL 78
Query: 395 LLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCE 454
LK+ + + R ++ L+ SL + YSE LKKELE +
Sbjct: 79 ALKRDDVTLL---------------RQEVQDLQASLKEEKWYSEE--LKKELEKY----Q 117
Query: 455 SAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVK 514
+Q K + AE ++L + E + ++ IKQ++D + ++ +K
Sbjct: 118 GLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN-IKQMKDLFEQKAAQLATEIADIK 176
Query: 515 QMQTHFLALKEHLTSEAASGNHRLTEELKDQ---LKDLKVKY--EGASAEVGKLRNQIKQ 569
+L+E + RLTEEL + ++DLK + +V L+ ++ Q
Sbjct: 177 SKYDEERSLREAAEQKVT----RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232
Query: 570 NEMIVE----EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 625
+ +++ E +R+ KL +E K+LQ + + E ++++ + + ++A+
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQSQYASSEAT-------ISQLRSELAKGPQEVAV 285
Query: 626 SIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ---HV 682
+ ++ + +KSS+ NE+ +K + L E + E+ +++ + E E+V K Q H
Sbjct: 286 YV--QELQKLKSSV-NELTQKNQTLTENLLKKEQDYTKLEEKHNE-ESVSKKNIQATLHQ 341
Query: 683 KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQK------EIEKVY---------LDNK 727
K + +Q++SRL L + EL+ K + QK E+E Y L +
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 728 LLKEQAHNLTIEMKNHYVPLKVSE---DMKKSHDAIIDDL---NRKLLDVTQKYTEKKLE 781
+++ H L ++ + + + K+ E + ++H + + + KL+D Q+ + +L+
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461
Query: 782 MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV----ELKKQLSELKKKCGED 837
+ +L + + + L+ ++ +E AL+ + E + L ++ ++ G+
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 838 QEKIHAL------TSENTNL-KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
+KI L + EN +L +K + Y ++ E LN L + N L
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQ------ 574
Query: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
E + Q K+K+++E K+ EN +Q++ + L + ++ SL S+ E+
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN-------ELN 627
Query: 951 ANYRKGQEEIVTLHAEIKAQ------------------KKELDTIQECIKVKYAPI---- 988
+ + +E++ L +IKA+ + LDT Q ++ K +
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 989 VSFEECERKFKATEK---ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLR 1045
++ K + ++ +L+ L E +KY E++ ++ + + KL+ + ++
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747
Query: 1046 DKTVLIEKSHEMERALSRKTDELNKQLK-----------DLSQKYTEVKNVKEKLVEENA 1094
+++ ++ L + EL+KQL+ DL +K ++++K+KL ++
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Query: 1095 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-KLH 1153
++ + L Q+ + Q E L + T+ L +++K + E TV KL
Sbjct: 808 EKQILKQDFETLSQETKI---QHEELNNRIQTTVTEL-QKVKMEKEALMTELSTVKDKLS 863
Query: 1154 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1213
++ ++ KNS K FEKE KA++ + E+ + E +LQ +++NT +
Sbjct: 864 KVSDSLKNS----------KSEFEKENQKGKAAILDLEKTCK---ELKHQLQVQMENTLK 910
Query: 1214 ALKKLETREVVDLSKYKATKSDLETQISSLNEKL--ANLNRKYEEVCEEVLHAKKKEISA 1271
K+L+ L K K L+ +++S+ E+L A K E E+ L E+
Sbjct: 911 EQKELKK----SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 1272 KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQ----ESAKQIEAKDNKITELLND 1327
E++ +++I+ + ++ TEL+ ++Q ++A+++ A+ KI+ L N+
Sbjct: 967 SSEQK------KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1328 VERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1371
E+ ++ L Y R+S+L+ T Q +KS+E++L+
Sbjct: 1021 YEKSQETFKQLQSDFY------GRESELLATRQ-DLKSVEEKLS 1057
Score = 125 bits (314), Expect = 3e-28
Identities = 185/918 (20%), Positives = 383/918 (41%), Gaps = 93/918 (10%)
Query: 276 NLTHMQDEVN-VKSHQREHQNIQD-----LEIENEDLKERLRKIQQEQRILLDKVNGLQL 329
N T +Q +++ K +E Q +Q L DL++ LR+I + + K+ L+
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ----KIQNLEA 530
Query: 330 QLNEEVMVADDLESEREKLKSLLAA-----------KEKQH---EESLRTIEALKNRFKY 375
L + LE ERE L + + A +EK H E+ + E LKN+ +
Sbjct: 531 LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590
Query: 376 FESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTS 435
+ +K + Q ++ ++ + +S+ + L++ + ++T
Sbjct: 591 HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN-ESKEKVSQLDIQIKAKTE 649
Query: 436 YSENEILKKELEAMRTFCESAKQDRLKL-QNELAHKVAECKALALECERVK---EDSDEQ 491
L EA +T + Q+ L QN L K E + + ++V +D E
Sbjct: 650 ------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703
Query: 492 IKQLEDALKD-------VQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEEL 542
QLE LK+ ++++ E EG++K+++ L +K + + +L +L
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 543 KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMER 602
+ + +L + E V R +++ +E K+ K EE + L+++ E
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 603 EKKGRK--------VTEMEGQAKELSAKLA-LSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
+ + + VTE++ E A + LS +K + SL N +E
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE-------F 876
Query: 654 EREHEKSLSEIRQLKRELENVKAKLA---QHVKPEEHEQVKSRLEQKSGELGKKITELTL 710
E+E++K + I L++ + +K +L ++ E+ E KS ++K K+ ++
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSM 936
Query: 711 KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 770
+ Q +Q + N+ ++Q E+K SE KK +A+ +L +L
Sbjct: 937 QEQLIQAQ--NTLKQNEKEEQQLQGNINELKQS------SEQKKKQIEALQGELKIAVLQ 988
Query: 771 VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 830
T+ E KL+ ++L L+ + ++ + EK ++ L+S+ + +L
Sbjct: 989 KTE--LENKLQ-QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 831 KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 890
++ +EK+ + + + + NQ ++ + K TL AK ++L + K
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKAL 1105
Query: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
+DI +E +K+K + +++ +IK E +++ L++ ++ + + + +
Sbjct: 1106 QDIQKE-KSLKEKELVNEKSKLAEIEEIKCR------QEKEITKLNEELKSHKLESIKEI 1158
Query: 951 ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 1010
N + ++ ++ E++ + L E K + + + K E+ELK +
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL------KDQVKKEEEELKKEFI 1212
Query: 1011 EQTQKY--SVSEEEV--KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1066
E+ K + E+EV KK+++ KL +I L ++L + S L ++TD
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 1067 ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
+L ++ L ++ + L+E K EI +Q + + L+ A + L
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332
Query: 1127 TIENLKEELKSMQRCYEK 1144
EN ++K Q K
Sbjct: 1333 --ENQSLQIKHTQALNRK 1348
Score = 95.1 bits (235), Expect = 4e-19
Identities = 103/454 (22%), Positives = 211/454 (46%), Gaps = 42/454 (9%)
Query: 252 LKTASENTNKGRELWKKGPSLQQRNLTHMQDEV--NVKSHQREHQNIQDLEIENEDLKER 309
LK + E + K + Q L Q+ + N K Q+ NI +L+ +E K++
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 310 LRKIQQEQRILLDKVNGLQLQLNEEV-MVADDLESEREKLKSLLAAKEKQHEESLRTIEA 368
+ +Q E +I + + L+ +L +++ A +L +E+EK+ L EK E
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET------- 1027
Query: 369 LKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLEL 428
FK +SD G S ++D+ + ++ +A S Q++ L
Sbjct: 1028 ----FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-----LIQ 1078
Query: 429 SLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS 488
L + + E + KKE + ++ C+ A QD K ++ ++ K+ E E +K
Sbjct: 1079 ELKTAKATLEQDSAKKE-QQLQERCK-ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE------L 542
+++I +L + LK + + +K + + K L +A S + +E L
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 543 KDQLK--DLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 600
KDQ+K + ++K E E KL ++IK+ E+ +++ + +E KL + L + L +
Sbjct: 1197 KDQVKKEEEELKKEFIEKEA-KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
Query: 601 EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEK---AKKLVEMEREH 657
E + R+V+E+E Q +L ++A+ +++++ N +E+ ++ ++ E E
Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIAV---------LEATVQNNQDERRALLERCLKGEGEI 1306
Query: 658 EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK 691
EK +++ +L+R+L+N A + + + + Q+K
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 66.2 bits (160), Expect = 2e-10
Identities = 78/393 (19%), Positives = 170/393 (43%), Gaps = 47/393 (11%)
Query: 1046 DKTVLIEKSHEMERALSRK---TDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
D T+L ++ +++ +L + ++EL K+L +KY ++ + K ++E+ +
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKEL----EKYQGLQQQEAKPDGLVTDSSAELQS 139
Query: 1103 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKE-------QQTVTKLHQL 1155
++ L++ ++ +K L E+ ++ Y++E +Q VT+L +
Sbjct: 140 LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199
Query: 1156 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASL-----------REKEEESQNKMEEVSKL 1204
L + L L + E +V ++K L E+E ES+ +E KL
Sbjct: 200 LNKEATVIQDLKTELLQRPGIE-DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 1205 QSEVQNTKQALKKLETR----------EVVDLSKYKATKSDLETQISSLNEKLANLNRKY 1254
QS+ +++ + +L + V +L K K++ ++L + +L E L + Y
Sbjct: 259 QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
Query: 1255 EEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQI 1314
++ E+ ++ +S K+ + LH + + + + R S T++ + + E +
Sbjct: 319 TKLEEK---HNEESVSKKNIQATLHQK-DLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 1315 EAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADAD 1374
+ +++E+ + LK L Q K Q L LQ ++ L +L + +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQ-----REEKEQHGL--QLQSEINQLHSKLLETE 427
Query: 1375 RQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQI 1407
RQ E + +++ MD++ Q A LQ+
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 172 bits (435), Expect = 3e-42
Identities = 245/1056 (23%), Positives = 470/1056 (44%), Gaps = 157/1056 (14%)
Query: 443 KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 502
K +LEA +D ++ EL A+ + L EC +K+D D+ LE L V
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 965
Query: 503 QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV---KYEGASAE 559
+K + +E KVK + L E + ++ L E + L DL+ K +
Sbjct: 966 EKEKHATENKVKNLTEELSGLDETI-AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
KL Q++ E +E+ K+ L ++L+ +L + + + ++E ++L
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-------ESILDLENDKQQL 1077
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
+L +K + L ++V ++ ++ +++ ++ + I +L+ E+E +A A
Sbjct: 1078 DERL------KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA 1131
Query: 680 QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 717
+ K E E++ RLE+ G EL KK + E TL+++ +
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191
Query: 718 EIEKVYLDNKL-LKEQAHNLT-----IEMKNHYVPLKVSEDMKKSHDAI------IDDLN 765
+ K + D+ L EQ NL +E + L++ +D+ S +++ ++ +
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI-DDLSSSMESVSKSKANLEKIC 1250
Query: 766 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF--VPPEKHEKEIIA--LKSNIV 821
R L D + K E+++ L E L+ SRL+T + + EKE I L +
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSE---LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Query: 822 ELKKQLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 877
+Q ELK++ E+ + HAL S + ++ QY + +E K L L+
Sbjct: 1308 AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD-LLREQY---EEEQEGKAELQRALS 1363
Query: 878 KTNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA------ 930
K N E+ + K+E D Q ++++ + L + L++++ Q++A A E
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 931 -----------KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ- 978
+ +SL+ ++ K Q + ++LA ++ EE AE++A KE ++
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES---QAELEASLKESRSLST 1480
Query: 979 ECIKVKYA---PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKK 1035
E K+K A + E +R+ K E+E+ D L+EQ + + E++K++++ + K
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIAD-LTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 1036 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1095
+I Q L + +E HE E + R EL + ++ +K E E+L + N +
Sbjct: 1540 DI---QLALEEAEAALE--HE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQL-KRNYQ 1592
Query: 1096 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1155
+T E + Q+ L + + LKK + G + ++ +L R + +T+ L +
Sbjct: 1593 RTVETM--QSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR---QAAETLKHLRSV 1647
Query: 1156 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQAL 1215
K++ + L + L+ +E ++++ I+ E + EV +L++ ++ T++A
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIV-------ERRANLLQAEVEELRATLEQTERA- 1699
Query: 1216 KKLETREVVDLSKYKA-----------TKSDLETQISSLNEKLANLNRKYEEVCEEVLHA 1264
+KL +E++D ++ TK LET + L ++ + +R E+ A
Sbjct: 1700 RKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKA 1759
Query: 1265 ----------KKKEISAKDEKELLHFSIEQEIKDQKERCDKS--------LTTITELQRR 1306
KKE E + ++EQ +KD + R D++ I +L+ R
Sbjct: 1760 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETR 1819
Query: 1307 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK---RQSQLIDTLQHQV 1363
I+E ++E + K TE V+ L++ + +LTY S K R L+D LQ +V
Sbjct: 1820 IRELEFELEGEQKKNTE---SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1876
Query: 1364 KSLEQQLADADRQHQEVIAIYR--THLLSAAQGHMD 1397
KS ++Q +AD Q + +R H L A+ D
Sbjct: 1877 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERAD 1912
Score = 141 bits (356), Expect = 4e-33
Identities = 189/896 (21%), Positives = 395/896 (44%), Gaps = 114/896 (12%)
Query: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 642
K + ++ +KE++ + E +K ++ + E + KEL KL + K+ L +
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLV------QEKNDLQLQ 891
Query: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
V +++ L++ E ++ + QL+ +++ V + E+ E++ + L K +L
Sbjct: 892 VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE------RAEDEEEINAELTAKKRKLE 945
Query: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL----KVSEDMKKSHD 758
+ +EL L+ + KV + + + NLT E+ + + + ++++H
Sbjct: 946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ 1005
Query: 759 AIIDDLNRK-----LLDVTQKYTEKKLE-MEKLLLENDSLSKDVSRLETVFVPPEKHEKE 812
+DDL + L+ T+ E+++E +E L + L D+ R + K E +
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK------RKLEGD 1059
Query: 813 IIALKSNIVEL---KKQLSE-LKKKCGED---QEKIHALTSENTNLKKMMSNQYVPVKTH 865
+ + +I++L K+QL E LKKK E Q K+ + +K + ++
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119
Query: 866 EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 925
EE T AKT ++ D ++ E++++ ++++ + +E + + +AE++ L
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSE---RLEEAGGVTSTQIELNKKR-EAEFLKL 1175
Query: 926 --------AEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKEL 974
+HEA +++L +K DS AE+ + N ++ ++++ +E K + +L
Sbjct: 1176 RRDLEEATLQHEAMVAAL---RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL 1232
Query: 975 DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK 1034
+ E S + + + + L+DQLSE K + + + + +L+
Sbjct: 1233 SSSME----------SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 1282
Query: 1035 KEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-------------------- 1074
E L + L +K ++ + ++A +++T+EL +QL++
Sbjct: 1283 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 1075 -LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-LEQVEALKKSLNGTIENLK 1132
L ++Y E + K +L +K SE+ + + + E++E KK L +++ +
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE 1402
Query: 1133 EELKSMQRCYEKEQQTVTKLHQLLEN---QKNSSVPLAEHLQIKEA-FEKEVGIIKASLR 1188
E+++++ ++T +L +E+ + LA L K+ F+K + K
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 1189 EKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-LSKYKATKSDLETQISSLNEKL 1247
E + E + ++E L +E+ K A + E +D L K +LE +I+ L E++
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYE-----EALDQLETVKRENKNLEQEIADLTEQI 1517
Query: 1248 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1307
A + E L +K+I EK + ++E+ + K L EL +
Sbjct: 1518 AENGKTIHE-----LEKSRKQIEL--EKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Query: 1308 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1367
E ++I KD +I +L + +R + + S N R L ++ + +E
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR---LKKKMEGDLNEIE 1627
Query: 1368 QQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQEALLQIIQMRQGLV 1415
QL+ A+RQ E + R+ L Q H+D ED++E L I++ R L+
Sbjct: 1628 IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ-LAIVERRANLL 1682
Score = 141 bits (355), Expect = 5e-33
Identities = 205/991 (20%), Positives = 423/991 (42%), Gaps = 147/991 (14%)
Query: 271 SLQQRNLTHMQDEVNVKSHQRE----HQNIQDLEIENEDLKERLRKIQQEQRILLDKVN- 325
SL+Q + E N + + + ++I DLE + + L ERL+K E L KV
Sbjct: 1038 SLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED 1097
Query: 326 ----GLQLQLNEEVMVA--DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESD 379
GLQ Q + + A ++LE E E ++ A EKQ + R +E L R + E+
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE--EAG 1155
Query: 380 HLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSEN 439
+ S N+K + +E
Sbjct: 1156 GVTSTQIELNKKRE-------------------------------------------AEF 1172
Query: 440 EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL 499
L+++LE E+ L+ + A VAE +RVK+ +++ + + +
Sbjct: 1173 LKLRRDLEEATLQHEAMVA---ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 500 KDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAE 559
D+ M ES K K E SEA N EE++ L +L + E
Sbjct: 1230 DDLSSSM-ESVSKSKANLEKICRTLEDQLSEARGKN----EEIQRSLSELTTQKSRLQTE 1284
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
G+L Q+++ E IV + R + ++ + L+++L E E K + Q+
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL-----EEENKAKNALAHALQSSRH 1339
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
L L E+ + K+ L +++ ++ + ++E ++ Q ELE K KLA
Sbjct: 1340 DCDL-LREQYEEEQEGKAELQRALSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKLA 1395
Query: 680 QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 739
Q ++ E EQV++ + K L Q LQ E+E + +D E+A++L
Sbjct: 1396 QRLQDSE-EQVEA--------VNAKCASLEKTKQRLQGEVEDLMVD----VERANSLAAA 1442
Query: 740 MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
+ D K+ + ++ L + K E + E+E L E+ SLS ++ +L
Sbjct: 1443 L-----------DKKQRN------FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485
Query: 800 ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 859
+ + E+ ++ +K L++++++L ++ E+ + IH L ++ ++
Sbjct: 1486 KNAY---EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Query: 860 VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK 919
+ + EE + L AK R L++ + +I+++ + ++ E LKRN + T ++
Sbjct: 1543 LAL---EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 920 AEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQK--KELDTI 977
+ +A++ S ++++R + ++ + EI HA +A + K L ++
Sbjct: 1600 SAL------DAEVRSRNEAIRLKKKMEGDL------NEIEIQLSHANRQAAETLKHLRSV 1647
Query: 978 QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1037
Q +K + ++ R +++LK+QL+ ++ ++ + EV++ + ++ ++
Sbjct: 1648 QGQLKDTQ---LHLDDALRG----QEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 1038 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1097
+++L D ++ H +L +L L L + + E+ K
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE--------LKSMQRCYEKEQQTV 1149
++ + L+K+ +E +KK+L T+++L+ LK ++ +K + +
Sbjct: 1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820
Query: 1150 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQS 1206
+L LE ++ + + L+ E KE+ + EE+ +N + + V KLQ
Sbjct: 1821 RELEFELEGEQKKNTESVKGLRKYERRVKEL------TYQSEEDRKNVLRLQDLVDKLQV 1874
Query: 1207 EVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
+V++ K+ ++ + + L+K++ + +LE
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905
Score = 86.3 bits (212), Expect = 2e-16
Identities = 84/419 (20%), Positives = 193/419 (46%), Gaps = 53/419 (12%)
Query: 977 IQECIKVKYAPIVS-FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKK 1035
I+ + VK+ P + F + + K+ E E +++ +++ +++E+ K++ + +L++
Sbjct: 819 IRSFMNVKHWPWMKLFFKIKPLLKSAETE--KEMATMKEEFQKTKDELAKSEAKRKELEE 876
Query: 1036 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK-------QLKDLSQKYTEVKNVKEK 1088
++ TL ++ D + ++ E + D+L K ++K+++++ + + + +
Sbjct: 877 KLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 936
Query: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
L + K E ++ + + L +VE K + ++NL EEL + +T
Sbjct: 937 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD-------ET 989
Query: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
+ KL + + + + + LQ +E + K+ L ++ E+ ++ +E+ KL+ ++
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049
Query: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1268
+ K+ L+ DL + + DLE L+E+L + +Y ++ +V
Sbjct: 1050 ERNKRKLEG-------DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV------- 1095
Query: 1269 ISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV 1328
++++ L +++IK ELQ RI+E ++IEA+ + T +
Sbjct: 1096 ----EDEQTLGLQFQKKIK--------------ELQARIEELEEEIEAE--RATRAKTEK 1135
Query: 1329 ERLKQA--LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
+R A L LS+ +G T Q +L + + L + L +A QH+ ++A R
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Score = 52.8 bits (125), Expect = 2e-06
Identities = 69/374 (18%), Positives = 161/374 (43%), Gaps = 37/374 (9%)
Query: 274 QRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNE 333
Q LT ++ E++ K +++ E++++ R Q+ + ++ NE
Sbjct: 1563 QLELTQVKSEIDRKIAEKD-----------EEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611
Query: 334 EVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK--YFESDHLGSGSHFSNRK 391
+ + +E + +++ L+ +Q E+L+ + +++ + K D G +
Sbjct: 1612 AIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671
Query: 392 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP--LELSLPSQTSYSENEIL---KKEL 446
++ ++ + A+ + + ++R + L+ + Q +++N L KK+L
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731
Query: 447 EA----MRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS---DEQIKQLEDAL 499
E +++ E A +D + + + + +A E ++ ++ S + K LE +
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791
Query: 500 KDVQKRMYESE-----GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QLKD 548
KD+Q R+ E+E G KQ+Q ++E L E + TE +K ++K+
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETRIRE-LEFELEGEQKKNTESVKGLRKYERRVKE 1850
Query: 549 LKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRK 608
L + E V +L++ + + ++ V+ +KR + E+ + + E E+ +
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Query: 609 VTEMEGQAKELSAK 622
E Q +L AK
Sbjct: 1911 ADIAESQVNKLRAK 1924
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 172 bits (435), Expect = 3e-42
Identities = 237/1034 (22%), Positives = 464/1034 (44%), Gaps = 141/1034 (13%)
Query: 459 DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 517
+R + + E+ A A+ + L EC +K+D D+ LE L V+K + +E KVK +
Sbjct: 927 ERAEEEEEINAELTAKKRKLEDECSELKKDIDD----LELTLAKVEKEKHATENKVKNLT 982
Query: 518 THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF 577
L E + ++ + L E + L DL+ AE K+ K + ++
Sbjct: 983 EEMAGLDETI-AKLSKEKKALQETHQQTLDDLQ-------AEEDKVNILTKAKTKLEQQV 1034
Query: 578 KRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKELSAKLALSIPAEKFEN 634
EG L +E K R+ E + ++E + K +ME ++L KL EK E
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKL------EKKEF 1088
Query: 635 MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE-----EHEQ 689
S+L +++ ++ ++++++ ++ + I +L E+E +A A+ K E E+
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148
Query: 690 VKSRLEQKSG------ELGKK-----------ITELTLKNQTLQKEIEKVYLDNKL-LKE 731
+ RLE+ G EL KK + E TL+++ + + K + D+ L E
Sbjct: 1149 ISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGE 1208
Query: 732 QAHNLTI---EMKNHYVPLKV-SEDMKKSHDAI------IDDLNRKLLDVTQKYTEKKLE 781
Q NL +++ LK+ ++D+ + +AI ++ + R L D + K+ E
Sbjct: 1209 QIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268
Query: 782 MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK----QLSELKKKCGED 837
++L+ + L+ +RL+T + E AL S + K+ Q+ ELK + E+
Sbjct: 1269 QQRLI---NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 838 QEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE-D 892
+ HAL S + ++ QY + +E K L L+K N E+ + K+E D
Sbjct: 1326 TKAKNALAHALQSSRHDCD-LLREQY---EEEQEGKAELQRALSKANSEVAQWRTKYETD 1381
Query: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS----MRKVQDSNA- 947
Q ++++ + L + L+ + ++A A E L M V+ SNA
Sbjct: 1382 AIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA 1441
Query: 948 ------------EILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEEC 994
++L+ +++ EE AE++A +KE ++ E KVK S ++
Sbjct: 1442 CAALDKKQRNFDKVLSEWKQKYEET---QAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 995 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1054
E + K L+ ++S+ T++ + +++ + ++ ++++E +Q L + +E
Sbjct: 1499 ET-LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE-- 1555
Query: 1055 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1114
HE E + R ELN+ ++ +K E E++ + T + +Q+ L +
Sbjct: 1556 HE-EGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHTRVVETMQSTLDAEIRSR 1611
Query: 1115 EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE 1174
+KK + G + ++ +L R + + +L K + + L + L+ +E
Sbjct: 1612 NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGIL---KETQLHLDDALRGQE 1668
Query: 1175 AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKS 1234
++++ I+ E + E+ +L + ++ T+++ +K+ +E++D S+
Sbjct: 1669 DLKEQLAIV-------ERRANLLQAEIEELWATLEQTERS-RKIAEQELLDASERVQLLH 1720
Query: 1235 DLETQISSLNEKLAN----LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSI--EQEIKD 1288
T + + +KL N L + EEV +E +A++K A + ++ + EQ+
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780
Query: 1289 QKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITELLNDVE----RLKQAL 1335
ER K+L T+ +LQ R+ E+ KQI+ + ++ EL +VE R +A+
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV 1840
Query: 1336 NGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
GL +LTY + K R L+D LQ +VKS ++Q +A+ Q ++ +R
Sbjct: 1841 KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 1386 --THLLSAAQGHMD 1397
H L A+ D
Sbjct: 1901 KLQHELEEAEERAD 1914
Score = 152 bits (383), Expect = 3e-36
Identities = 212/1066 (19%), Positives = 459/1066 (43%), Gaps = 119/1066 (11%)
Query: 244 DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 299
D+L+ LTL K E NK + L ++ L + +++ K+ Q HQ + DL
Sbjct: 958 DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEK---KALQETHQQTLDDL 1013
Query: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
+ E ++++ + + + L +V+ L+ L +E + DLE + KL+ L ++
Sbjct: 1014 QAE----EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069
Query: 360 EESLRTIEALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHM 417
+ + L + K FE +L S E L K+ + A + I A
Sbjct: 1070 MDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 1129
Query: 418 QSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAEC 474
SR+ L S+ +E L++ A E K+ KL+ +L +
Sbjct: 1130 ASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH 1188
Query: 475 KALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASG 534
+A+ + DS ++ + D L+ V++++ + + ++K M+T L+ S+A
Sbjct: 1189 EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELK-METDDLSSNAEAISKAKGN 1247
Query: 535 NHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 594
++ L+DQ+ +LK K E + L Q + + E+ R ++E L +
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ----LDEKDALVSQ 1303
Query: 595 LSMCEMEREKKGRKVTEMEGQAKE-LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
LS ++ +++ E++ Q +E AK AL+ + + L + E+ + E+
Sbjct: 1304 LSR---SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1360
Query: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
+R K+ SE+ Q + + E + + EE E+ K +L Q+ E + + + K
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 773
+L+K ++ L+ + +L ++++ + +++ D ++ + Q
Sbjct: 1416 SLEKTKQR-------LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK-------Q 1461
Query: 774 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 833
KY E + E+E E+ SLS ++ +++ V+ E+ ++ L+ L++++S+L ++
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVY---EESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 834 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFED 892
E ++IH L +KK + + ++ EE + +L K R L++ + +
Sbjct: 1519 IAEGGKQIHELEK----IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSE 1574
Query: 893 INQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAEH-------EAKMSSLSQSMRK 941
++++ + ++ + LKRN +E Q+ + AE S + E ++ + +
Sbjct: 1575 VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNH 1634
Query: 942 VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKAT 1001
AE L NYR Q +K + LD
Sbjct: 1635 ANRLAAESLRNYRNTQ-------GILKETQLHLDDALR---------------------G 1666
Query: 1002 EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1061
+++LK+QL+ ++ ++ + E+++ ++ ++ +++L D + ++ H +L
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726
Query: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
+L + L + EV E+ K ++ + L+K+ +E +K
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786
Query: 1122 KSLNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1173
K+L T+++L+ LK ++ +K + V +L +EN++ + + L+
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846
Query: 1174 EAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1230
E KE+ + EE+ +N + + V KLQ++V++ K+ ++ E + +LSK++
Sbjct: 1847 ERRVKEL------TYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1276
+ +LE + + +N+ L K +E+ K E
Sbjct: 1901 KLQHELEEAEERADIAESQVNK---------LRVKSREVHTKISAE 1937
Score = 144 bits (363), Expect = 6e-34
Identities = 227/1045 (21%), Positives = 442/1045 (42%), Gaps = 149/1045 (14%)
Query: 411 PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL---EAMRTFCESAKQDRLKLQNEL 467
P + + + +L+ E T E + K EL EA R E LK +N+L
Sbjct: 831 PWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL 890
Query: 468 AHKV-AECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
+V +E +LA ER ++ +I QLE +K+V +R E E ++ A K
Sbjct: 891 QLQVQSEADSLADAEERCEQLIKNKI-QLEAKIKEVTERAEEEE----EINAELTAKKRK 945
Query: 527 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 586
L E + ELK + DL++ E N++K L E
Sbjct: 946 LEDECS--------ELKKDIDDLELTLAKVEKEKHATENKVKN--------------LTE 983
Query: 587 ENKRLQKELSMCEMEREKKGRKVTEMEG----QAKELSAKLALSIPAEKFENMKSSLSNE 642
E L + ++ ++ +EKK + T + QA+E + L+ K E L
Sbjct: 984 EMAGLDETIA--KLSKEKKALQETHQQTLDDLQAEEDKVNI-LTKAKTKLEQQVDDLEGS 1040
Query: 643 VNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQHVKPEEHE--QVKSRLEQK 697
+ ++ K +++ER K +++ + ++EN K +L + ++ +E E + S++E +
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100
Query: 698 SG---ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 754
+L KKI EL + + L +EIE ++Q +L+ E++ ++SE ++
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELE------EISERLE 1154
Query: 755 KSHDAIID--DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKE 812
++ A +LN+K QK + ++E+ L+++++ V +KH
Sbjct: 1155 EAGGATSAQVELNKKREAEFQKL---RRDLEEATLQHEAM---------VAALRKKHADS 1202
Query: 813 IIALKSNI-------VELKKQLSELKKKCGEDQEKIHALTSENTNLKKM---MSNQYVPV 862
+ L I +L+K+ SELK + + A++ NL+KM + +Q +
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262
Query: 863 KTHEEVKMTL-NDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 921
KT EE + L ND A+ R + + ++++ + L R+ + + QI+
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEEL 1318
Query: 922 YISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECI 981
L E ++L+ +++ + + Y + QE L + E+ Q
Sbjct: 1319 KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV--AQWRT 1376
Query: 982 KVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1041
K + I EE E E K +L+++ Q+ +EE V+ + L+K LQ
Sbjct: 1377 KYETDAIQRTEELE--------EAKKKLAQRLQE---AEEHVEAVNAKCASLEKTKQRLQ 1425
Query: 1042 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIL 1101
++ D + +E+S+ AL +K +K L + QKY E + E +E+ ++E+
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 1102 AVQNLLQKQHVPLEQVEALKKSLNGTIENLKE-------ELKSMQRCYEKEQQTVTKLHQ 1154
V+N+ ++ LE + K+L I +L E ++ +++ ++ +Q ++
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545
Query: 1155 LLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1213
LE + S EH + K + E+ +K+ + K E +++++ + + V T Q
Sbjct: 1546 ALEEAEAS----LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQ 1601
Query: 1214 ALKKLETREVVDL----SKYKATKSDLETQISSLNEKLANLNRKY--------------- 1254
+ E R D K + +++E Q++ N A R Y
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLD 1661
Query: 1255 ------EEVCEE---------VLHAKKKEISAK-DEKELLHFSIEQEIKDQKERCDKSLT 1298
E++ E+ +L A+ +E+ A ++ E EQE+ D ER T
Sbjct: 1662 DALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHT 1721
Query: 1299 TITEL---QRRIQESAKQIEAK-DNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1354
T L +++++ Q++++ + I E N E+ K+A+ + + K++
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM----AEELKKEQD 1777
Query: 1355 LIDTLQHQVKSLEQQLADADRQHQE 1379
L+ K+LEQ + D + E
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDE 1802
Score = 86.3 bits (212), Expect = 2e-16
Identities = 81/396 (20%), Positives = 179/396 (45%), Gaps = 50/396 (12%)
Query: 997 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK--- 1053
K TEKE+ + E+ QK +++E+ K++ + +L++++ TL K+ D + ++
Sbjct: 844 KSAETEKEMAT-MKEEFQK---TKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD 899
Query: 1054 ----SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
+ E L + +L ++K+++++ E + + +L + K E ++ +
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD 959
Query: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
+ L +VE K + ++NL EE+ + +T+ KL + + + + +
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMAGLD-------ETIAKLSKEKKALQETHQQTLDD 1012
Query: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
LQ +E + K L ++ ++ + +E+ KL+ +++ K+ L+ DL
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG-------DLKLA 1065
Query: 1230 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1289
+ + D+E L+EKL +K E+ IS ++++ + ++++IK
Sbjct: 1066 QESTMDMENDKQQLDEKL---EKKEFEI--------SNLISKIEDEQAVEIQLQKKIK-- 1112
Query: 1290 KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPT 1349
ELQ RI+E ++IEA+ + L + L +S+ +G T
Sbjct: 1113 ------------ELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Query: 1350 KRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
Q +L + + + L + L +A QH+ ++A R
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 171 bits (434), Expect = 4e-42
Identities = 231/1121 (20%), Positives = 477/1121 (42%), Gaps = 122/1121 (10%)
Query: 290 QREHQNIQDLEIENEDLKERLRKIQQEQRI-----LLDKVNGLQLQLNEEVMVADDLESE 344
Q Q + + E E +K R +++ E R+ L ++ +LQL E++ +L +E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 345 REKLKSLLAAKEKQHEESLRTIEAL----KNRFKYFESDHLGSGSHFSNRKEDMLLKQG- 399
E+L++ L AK+++ EE +EA + R ++ +++ + +E + ++
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 400 -QMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ 458
Q + T + + + +L L + E+ I E T E +
Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI--AEFTTNLTEEEEKSK 1016
Query: 459 DRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQT 518
KL+N+ + + + E+ +++ ++ ++LE D+ ++ E + ++ +++
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076
Query: 519 HFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFK 578
+E L + A R+ EE + LK ++ +L +QI + + +E +
Sbjct: 1077 QLAKKEEELQAALA----RVEEEAAQKNMALK--------KIRELESQISELQEDLESER 1124
Query: 579 RDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN-MKS 637
K ++ + L +EL + TE+E +A+ L E+ N +K
Sbjct: 1125 ASRNKAEKQKRDLGEELEALK----------TELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 638 SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQK 697
+L E ++ EM ++H +++ E+ + + + VKA L E+ K LE +
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL---------EKAKQTLENE 1225
Query: 698 SGELGKKITELTL---KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 754
GEL ++ L ++ +K++E + ++ + + E+ + L+V D
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 755 KSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLE----TVFVPP 806
+ D + KL + + ++LL E + SLS + ++E +
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 807 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 866
E+ E+ L+ I L Q++++KKK ++ + L + +K+ + + HE
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKM---EDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 867 EVKMTLNDTLAKT----NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 922
E K+ D L KT +EL D+ + Q ++ K + + L + I A+Y
Sbjct: 1403 E-KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE-EKTISAKY 1460
Query: 923 --------ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANYRKGQEEIVTLHAEIKAQK 971
E E K SL++++ + + AE + +R E++++ ++
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 972 KELDTIQECIKVKYAPI-VSFEECERKFKATE-KELKDQLSEQTQKYSVSEEEVKKNKQE 1029
EL+ + ++ + + EE E + +ATE +L+ +++ Q K + +++Q
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 1030 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1089
+K K+ L + +R+ +E + +L LKDL +++
Sbjct: 1581 EEKKKQ----LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 1090 VEENAKQTSEILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCY 1142
+++ K +++ L E++ E KS+ + L+EEL + +R
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 1143 EKEQQTVTKLHQLLENQKNSSVPLAEH--------LQIKEAFEKEVG--------IIKAS 1186
+ QQ +L + N E Q++E E+E G + KA+
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 1187 LREKE-------EESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ 1239
L+ + E S + E ++ Q E QN K+ KL+ E SKYKA+ + LE +
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQN-KELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 1240 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ-KERCDKSLT 1298
I+ L E+L N ++ + C++V +KK KD LL E+ +Q K++ DK+ T
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKK---LKD--VLLQVDDERRNAEQYKDQADKAST 1870
Query: 1299 TITELQRRIQES---AKQIEAKDNKITELLNDVERLKQALN 1336
+ +L+R+++E+ A++ A K+ L D A+N
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Score = 156 bits (395), Expect = 1e-37
Identities = 178/857 (20%), Positives = 373/857 (43%), Gaps = 82/857 (9%)
Query: 568 KQNEMI-VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 626
K+ E++ V E + + E + LQ +L +++ +++ + TE+ +A+EL A+L
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 627 IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 686
++ E + L V E+ ++ ++ E +K I++L+ +LE EE
Sbjct: 910 --KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE-----------EE 956
Query: 687 HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 746
+ K +LE+ + E K+ +L + L+ + K+ + KLL+++ T +
Sbjct: 957 SARQKLQLEKVTTEA--KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 747 LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS--LSKDVSRLETVFV 804
K +K H+A+I DL +L ++ ++LE + LE DS LS ++ L+
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLR--REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 805 PPE----KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT----SENTNLKKMMS 856
+ K E+E+ A + + E Q + KK E + +I L SE + K
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 857 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQN 916
+ + E +K L DTL T + K+ +++N ILK+ LE
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN-----------ILKKTLEE--- 1178
Query: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-- 974
+ K + E K S + + + + + AN K ++ + E+ + K L
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 975 ---DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEV----KKNK 1027
D+ + KV+ +E + KF E+ ++ +L+++ K V + V ++
Sbjct: 1239 GKGDSEHKRKKVE----AQLQELQVKFNEGER-VRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 1028 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1087
++ KL K+ L+ L+D L+++ + + +LS K ++ + ++ E + K
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 1088 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1147
L ++ A +++ ++ ++ LE E +K+ L +E L + + Y+K ++
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 1148 TVTKLHQLLEN------------------QKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1189
T T+L Q L++ QK LAE I + +E +A RE
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
KE K +++ E K L++L + ++ ++K D+ + L +
Sbjct: 1474 KE----TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA 1529
Query: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE----QEIKDQKERCDKSLTTITELQR 1305
L ++ EE+ ++ + + + +D K L +++ Q +D + R ++S +L R
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 1306 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1365
+++E ++E + + + + ++L+ L L ++ + + LQ Q+K
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 1366 LEQQLADADRQHQEVIA 1382
++L D +E++A
Sbjct: 1650 CMRELDDTRASREEILA 1666
Score = 134 bits (338), Expect = 5e-31
Identities = 202/1033 (19%), Positives = 433/1033 (41%), Gaps = 112/1033 (10%)
Query: 274 QRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNE 333
Q+N+ +++++ + R Q L++E + +L+K+++EQ IL D+ +L +
Sbjct: 942 QQNIQELEEQLEEEESAR-----QKLQLEKVTTEAKLKKLEEEQIILEDQ----NCKLAK 992
Query: 334 EVMVADD--------LESEREKLKSLLAAKEKQH------EESLRTIEALKNRFKYFESD 379
E + +D L E EK KSL K K EE LR E + +
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 380 HLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSEN 439
G + S++ ++ Q +A+ + +Q+ ++ R E + + +
Sbjct: 1053 LEGDSTDLSDQIAEL-----QAQIAELKMQLAKKEEELQA-ALARVEEEAAQKNMALKKI 1106
Query: 440 EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS--DEQIKQLED 497
L+ ++ ++ ES + R K + + E +AL E E + + ++++ +
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 498 ALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS 557
++ K+ E E K + Q + K E + T+ +K L+ K E
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN-- 1224
Query: 558 AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK 617
E G+L N++K + + K+ + + LQ + + E R + KVT+++ +
Sbjct: 1225 -ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 618 ELSAKLALS-IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 676
++ L+ S + K S+L +++ + + L E R+ ++++Q++ E + +
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 677 KLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 736
+L EE E+ K LE++ L ++ ++ K + +E + L++ L
Sbjct: 1344 QL------EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397
Query: 737 TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK------YTEKKLEMEKLLLEND 790
+ + H + + ++K+ + +L+ L+D+ + +K+ + ++LL E
Sbjct: 1398 S---QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454
Query: 791 SLSKDVSRLETVFVPPEKHEKEIIALK-----SNIVELKKQLSELKKKCGEDQE------ 839
++S + E E EKE AL +E K +L L K+ + E
Sbjct: 1455 TISAKYAE-ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 840 -----KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 894
+H L L++ + ++ E+ D + L +K +FE
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--- 1570
Query: 895 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY- 953
++ +++E K+ L +++AE E E K S++ + RK + + + L +
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAEL----EDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 954 ---RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 1010
K ++E + +++AQ K+ C++ S EE + K EK+LK +
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKD------CMRELDDTRASREEILAQAKENEKKLKSMEA 1680
Query: 1011 EQTQ---KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDE 1067
E Q + + +E ++ +QE D+L EI + +E+ +E +++ +E
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEI---ANSSGKGALALEEKRRLEARIAQLEEE 1737
Query: 1068 LNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL-LQKQHVPLEQVEALKKSLNG 1126
L ++ Q TE+ N + K Q + L ++ QK +Q+E K L
Sbjct: 1738 LEEE-----QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Query: 1127 TIENLKEELKSMQRC-YEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKA 1185
++ ++ +KS + + + +L + L+N+ + ++ E K+V +
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 1186 SLREKEEESQNKMEEVS-----------KLQSEVQNTKQALKKLETREVVDLSKYKATKS 1234
R E+ +++ ++ S + + E Q + +KL+ RE+ D ++ T
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ-RELEDATE---TAD 1908
Query: 1235 DLETQISSLNEKL 1247
+ ++SSL KL
Sbjct: 1909 AMNREVSSLKNKL 1921
Score = 107 bits (267), Expect = 8e-23
Identities = 182/929 (19%), Positives = 370/929 (39%), Gaps = 139/929 (14%)
Query: 248 ILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLK 307
++T L+ K R+ +K + + T + D++ Q +Q L + E+L+
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ-LAKKEEELQ 1086
Query: 308 ERLRKIQQE---QRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLR 364
L ++++E + + L K+ L+ Q++E + +DLESER EKQ +
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISE---LQEDLESERASRNKA----EKQKRDLGE 1139
Query: 365 TIEALKNRFKYFESDHLGSGSHFSNRKEDM-LLKQG-------------QMYMADSQCTS 410
+EALK + S R++++ +LK+ +M SQ
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 411 PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK 470
Q++ + LE + QT +E L E++ + ++ R K++ +L
Sbjct: 1200 ELAEQLEQTKRVKANLEKA--KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ-- 1255
Query: 471 VAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSE 530
E + E ERV+ + +++ +L+ L +V + +S+ K ++ F AL+ L
Sbjct: 1256 --ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD- 1312
Query: 531 AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD----EGKLIE 586
L +E Q L K + E R Q+++ E ++ ++ +
Sbjct: 1313 ----TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 587 ENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEK 646
K+++ + E E K + ++EG ++ K+A +K E K+ L E+++
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY---DKLEKTKTRLQQELDDL 1425
Query: 647 AKKLVEMEREH------EKSLSEIRQLKRELENVKAKLAQHVKPEEHE------------ 688
LV+++ + EK + QL E + + AK A+ E E
Sbjct: 1426 ---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 689 -------QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 741
+ K+ LE+ + + ++ +L + K + ++ + L++Q + +++
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 742 NHYVPLKVSEDMKKSHD----AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS 797
L+ +ED K + A+ R L ++ EKK ++ + + E ++ +D
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 798 RLETVFVPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 849
+ ++ V K E I + N E KQL +L+ + + ++ +
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 850 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL-- 907
+ +K+ E + L + LA R +++ +++ E K +
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 908 -KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQ--------DSNAEILANYRKGQE 958
KR LE Q++ E L E + ++ ++K D N E ++ +K +
Sbjct: 1723 EKRRLEARIAQLEEE---LEEEQGNTELINDRLKKANLQIDQINTDLNLE-RSHAQKNEN 1778
Query: 959 EIVTLHAEIKAQKKELDTIQECIKVKY--------APIVSFEE------------CERKF 998
L + K K +L ++ +K KY A I EE C ++
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAAC-KQV 1837
Query: 999 KATEKELKD-------------QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT----LQ 1041
+ TEK+LKD Q +Q K S +++K+ +E ++ + LQ
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 1042 KDLRDKTVLIEKSHEMERALSRKTDELNK 1070
++L D T E + M R +S ++L +
Sbjct: 1898 RELEDAT---ETADAMNREVSSLKNKLRR 1923
Score = 42.4 bits (98), Expect = 0.003
Identities = 75/378 (19%), Positives = 156/378 (41%), Gaps = 67/378 (17%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQ-RNLTHMQDEVNVKSHQREHQNI--QDLEIENED 305
L +K E +GR+ + Q R + M+ E+ + QR + LE++ +D
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 306 LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT 365
L+ + + + + ++ LQ Q+ + + DD + RE++ A+ K++E+ L++
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEI----LAQAKENEKKLKS 1677
Query: 366 IEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPG-----IPAHMQSR 420
+EA + + + L + + + Q + +AD S G + +
Sbjct: 1678 MEAEMIQLQ----EELAAAERAKRQAQ-----QERDELADEIANSSGKGALALEEKRRLE 1728
Query: 421 SMLRPLELSLPSQTSYSE--NEILKK----------ELEAMRTFC---ESAKQDRLKLQN 465
+ + LE L + +E N+ LKK +L R+ E+A+Q +
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 466 ELAHKVAECK------------ALALECERVKEDSD----------EQIKQLEDALKDVQ 503
EL K+ E + AL + +++E D +Q+++ E LKDV
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848
Query: 504 KRMYESEGKVKQMQ-------THFLALKEHL--TSEAASGNHRLTEELKDQLKDLKVKYE 554
++ + +Q + T LK L E A + +L+ +L+D +
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908
Query: 555 GASAEVGKLRNQIKQNEM 572
+ EV L+N++++ ++
Sbjct: 1909 AMNREVSSLKNKLRRGDL 1926
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 171 bits (434), Expect = 4e-42
Identities = 236/1050 (22%), Positives = 468/1050 (44%), Gaps = 145/1050 (13%)
Query: 443 KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 502
K +LEA +D ++ EL A+ + L EC +K+D D+ LE L V
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 970
Query: 503 QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 562
+K + +E KVK + L E + +LT+E K + + + AE K
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIA--------KLTKEKKALQEAHQQTLDDLQAEEDK 1022
Query: 563 LRNQIKQNEMIVEEFKRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKEL 619
+ K + ++ EG L +E K R+ E + ++E + K + ++E + ++L
Sbjct: 1023 VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
KL +K E S+L +++ ++ ++++++ ++ + I +L+ E+E +A A
Sbjct: 1083 DEKL------KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 680 QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 717
+ K E E++ RLE+ G E+ KK + E TL+++
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 718 EIEKVYLDNKL-LKEQAHNLT----------IEMKNHYVPLKVSEDMKKSHDAIIDDLNR 766
+ K + D+ L EQ NL EMK L + + ++ + R
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 767 KLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK- 825
L D + K+ E ++L+ + L+ RL+T + E AL S + K+
Sbjct: 1257 TLEDQLSELKSKEEEQQRLI---NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 826 ---QLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878
Q+ ELK++ E+ + HAL S + ++ QY + +E K L L+K
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD-LLREQY---EEEQESKAELQRALSK 1369
Query: 879 TNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQ 937
N E+ + K+E D Q ++++ + L + L+ + ++A A E L
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 938 S----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIKAQKKELDTI-QE 979
M V+ +NA +ILA +++ EE HAE++A +KE ++ E
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELEASQKEARSLGTE 1486
Query: 980 CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1039
K+K A S ++ E K K L+ ++S+ T++ + + + + ++ ++++E
Sbjct: 1487 LFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ L + +E HE E + R ELN+ ++ +K E K++ +++ +
Sbjct: 1546 LQAALEEAEASLE--HE-EGKILRIQLELNQVKSEVDRKIAE----KDEEIDQLKRNHIR 1598
Query: 1100 IL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1158
I+ ++Q+ L + LKK + G + ++ +L R + + +L
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-- 1656
Query: 1159 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
K++ + L + L+ +E ++++ ++ E + E+ +L++ ++ T+++ +K+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELRATLEQTERS-RKI 1707
Query: 1219 ETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDE 1274
+E++D S+ T + + +KL + + + E++ +E +A++K A +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 1275 KELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITE 1323
++ + EQ+ ER K++ T+ +LQ R+ E+ KQI+ + ++ E
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827
Query: 1324 LLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQ 1369
L +VE R +A+ GL +LTY + K R L+D LQ +VKS ++Q
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 1370 LADADRQHQEVIAIYR--THLLSAAQGHMD 1397
+A+ Q +A +R H L A+ D
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Score = 143 bits (360), Expect = 1e-33
Identities = 221/1027 (21%), Positives = 446/1027 (43%), Gaps = 123/1027 (11%)
Query: 283 EVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILL--------------DKVNGL- 327
+V + H E++ +++L E L E + K+ +E++ L DKVN L
Sbjct: 969 KVEKEKHATENK-VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 328 --QLQLNEEVMVADDLESEREKLKSL----------LAAKEKQHEESLRTIEALKNRF-- 373
+++L ++V DDLE E+ K L L K +ES+ IE K +
Sbjct: 1028 KAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 374 ----KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS 429
K FE +L S L K+ + A + I A SR+
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 430 LPSQTSYSENEILKKELEAMRTFCESAKQ---DRLKLQNELAHKVAECKALALECERVKE 486
L S+ +E L++ A E K+ + K++ +L + +A A +
Sbjct: 1145 L-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 487 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 546
DS ++ + D L+ V++++ + + ++K M+ LA S+A ++ L+DQL
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
+LK K E + L Q + + EF R ++E + L +LS ++
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LDEKEALVSQLS---RGKQAFT 1315
Query: 607 RKVTEMEGQ-AKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 665
+++ E++ Q +E+ AK AL+ + + L + E+ + E++R K+ +E+
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 666 QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 725
Q + + E + + EE E+ K +L Q+ + + + K +L+K ++
Sbjct: 1376 QWRTKYETDAIQ-----RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---- 1426
Query: 726 NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 785
L+ + +L ++++ + +++ D I L + QK E E+E
Sbjct: 1427 ---LQNEVEDLMLDVERTNAACAALDKKQRNFDKI-------LAEWKQKCEETHAELEAS 1476
Query: 786 LLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 845
E SL ++ +++ + E+ ++ LK L++++S+L ++ E ++IH L
Sbjct: 1477 QKEARSLGTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL- 1532
Query: 846 SENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
+KK + + ++ EE + +L K R L++ + +++++ + ++
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 905 EILKRN----LENTQNQIKAEYIS-------LAEHEAKMSSLSQSMRKVQDSNAEILANY 953
+ LKRN +E+ Q+ + AE S + E ++ + + AE L NY
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649
Query: 954 RKGQ----EEIVTLHAEIKAQ---KKELDTIQECIKVKYAPI----VSFEECERKFKATE 1002
R Q + + L +++Q K++L ++ + A I + E+ ER K E
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709
Query: 1003 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
+EL D SE+ Q + K+ KL+ +I +Q ++ D +L E + E+A
Sbjct: 1710 QELLD-ASERVQLLHTQNTSLINTKK---KLETDISQMQGEMED--ILQEARNAEEKAKK 1763
Query: 1063 RKTD------ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1116
TD EL K+ +D S +K E+ V++ + E A Q L+ +++
Sbjct: 1764 AITDAAMMAEELKKE-QDTSAHLERMKKNMEQTVKDLQLRLDE--AEQLALKGGKKQIQK 1820
Query: 1117 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL-HQLLENQKNSSVPLAEHLQIKEA 1175
+EA + L G +E+ ++ + K ++ V +L +Q E++KN + + +
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN----ILRLQDLVDK 1876
Query: 1176 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1235
+ +V K E EE+S + + KLQ E++ ++ E++ ++K + +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSRE 1932
Query: 1236 LETQISS 1242
+ T++ S
Sbjct: 1933 VHTKVIS 1939
Score = 127 bits (320), Expect = 6e-29
Identities = 187/905 (20%), Positives = 381/905 (42%), Gaps = 147/905 (16%)
Query: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 642
K + ++ +KE++ + E +K ++ + E + KEL K+ + K+ L +
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE------KNDLQLQ 896
Query: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
V +A+ L + E ++ + QL+ +++ V + E+ E++ + L K +L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA------EDEEEINAELTAKKRKLE 950
Query: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
+ +EL +K+I+ + L ++++ H ++KN ++E+M A +D
Sbjct: 951 DECSEL-------KKDIDDLELTLAKVEKEKHATENKVKN------LTEEM-----AGLD 992
Query: 763 DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVE 822
+ KL EKK E D L + ++ T+ K E+++ L+ ++ +
Sbjct: 993 ETIAKLT------KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 823 LKK---QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 879
KK L K+K D + L E+ + E K L++ L K
Sbjct: 1047 EKKLRMDLERAKRKLEGDLK----LAQES-------------IMDIENEKQQLDEKLKKK 1089
Query: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 939
E+ +++ K ED ++++ K + L+ +E + +I+AE S A+ E + S LS+ +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 940 RKVQD--------SNAEILANYRKGQE--------EIVTLHAEIKA---QKKELDTIQEC 980
++ + ++A+I N ++ E E TL E A +KK D++ E
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209
Query: 981 --------------------IKVKYAPIVSFEECERKFKATEKE----LKDQLSEQTQKY 1016
+K++ + S E K K ++ L+DQLSE K
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-- 1074
+ + + +L+ E + L +K L+ + ++A +++ +EL +QL++
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 1075 -------------------LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-L 1114
L ++Y E + K +L +K +E+ + + +
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 1115 EQVEALKKSLNGTIENLKEELKSMQ-RCYEKE---QQTVTKLHQLLENQKNSSVPLAEHL 1170
E++E KK L ++ +E ++++ +C E Q+ ++ L+ + + ++ A
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 1171 QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1230
+ + F+K + K E E + +E L +E+ K A ++ + L K
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE----SLDQLETLK 1505
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
+L+ +IS L E++A ++ E L KK++ + EK L ++E+ +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKCELQAALEEAEASLE 1558
Query: 1291 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1350
K L EL + E ++I KD +I +L + R+ +++ S N
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618
Query: 1351 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQE 1402
R L ++ + +E QL A+R E + YR +L Q H+D ED++E
Sbjct: 1619 R---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 1403 ALLQI 1407
L +
Sbjct: 1676 QLAMV 1680
Score = 78.6 bits (192), Expect = 4e-14
Identities = 134/795 (16%), Positives = 315/795 (39%), Gaps = 50/795 (6%)
Query: 213 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSL 272
RD E +++ A + L DS A +G+ +D L +K E ++ +
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 273 QQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN 332
++ + + E Q + +L+ + E+ + + + ++ L + QL+
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 333 EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 392
E+ + L ++ + ++Q EE ++ AL + + D + +E
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 452
Q + A+++ ++ ++ R EL + + ++ +EA+
Sbjct: 1359 SKAELQRALSKANTEVAQ--WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 453 CESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYES 509
C S ++ + +LQNE+ + + + C ++ + + D+ + + + ++ + S
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 510 EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
+ + + + T +K EE DQL+ LK + + E+ L QI +
Sbjct: 1477 QKEARSLGTELFKIKNAY------------EESLDQLETLKRENKNLQQEISDLTEQIAE 1524
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA 629
+ E ++ + ++ +E LQ L E E + K+ ++ + ++ +++ I A
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-A 1583
Query: 630 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ 689
EK E + N + ++ E IR LK+++E ++ +
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMA 1642
Query: 690 VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKV 749
++ ++ + K T++ L + +E K L +++ +A+ L E++ L+
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL--AMVERRANLLQAEIEELRATLEQ 1700
Query: 750 SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH 809
+E +K + ++LLD +++ ++ L +N SL +LET +
Sbjct: 1701 TERSRKIAE-------QELLDASER-------VQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 810 EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY--VPVKTHEE 867
++I+ N E K+ E+ +K ++ +KK M + ++ E
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 868 VKMTLN------DTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 921
++ L L REL + + N E VK K+E + L + +
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 922 YISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
+ L + +AK+ S + + ++ + LA +RK Q E+ + +++ +
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Query: 978 QECIKVKYAPIVSFE 992
+ + + ++S E
Sbjct: 1927 RVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 171 bits (434), Expect = 4e-42
Identities = 236/1050 (22%), Positives = 468/1050 (44%), Gaps = 145/1050 (13%)
Query: 443 KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 502
K +LEA +D ++ EL A+ + L EC +K+D D+ LE L V
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 970
Query: 503 QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 562
+K + +E KVK + L E + +LT+E K + + + AE K
Sbjct: 971 EKEKHATENKVKNLTEEMAGLDETIA--------KLTKEKKALQEAHQQTLDDLQAEEDK 1022
Query: 563 LRNQIKQNEMIVEEFKRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKEL 619
+ K + ++ EG L +E K R+ E + ++E + K + ++E + ++L
Sbjct: 1023 VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
KL +K E S+L +++ ++ ++++++ ++ + I +L+ E+E +A A
Sbjct: 1083 DEKL------KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 680 QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 717
+ K E E++ RLE+ G E+ KK + E TL+++
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 718 EIEKVYLDNKL-LKEQAHNLT----------IEMKNHYVPLKVSEDMKKSHDAIIDDLNR 766
+ K + D+ L EQ NL EMK L + + ++ + R
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 767 KLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK- 825
L D + K+ E ++L+ + L+ RL+T + E AL S + K+
Sbjct: 1257 TLEDQLSELKSKEEEQQRLI---NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 826 ---QLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878
Q+ ELK++ E+ + HAL S + ++ QY + +E K L L+K
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD-LLREQY---EEEQESKAELQRALSK 1369
Query: 879 TNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQ 937
N E+ + K+E D Q ++++ + L + L+ + ++A A E L
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 938 S----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIKAQKKELDTI-QE 979
M V+ +NA +ILA +++ EE HAE++A +KE ++ E
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELEASQKEARSLGTE 1486
Query: 980 CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1039
K+K A S ++ E K K L+ ++S+ T++ + + + + ++ ++++E
Sbjct: 1487 LFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ L + +E HE E + R ELN+ ++ +K E K++ +++ +
Sbjct: 1546 LQAALEEAEASLE--HE-EGKILRIQLELNQVKSEVDRKIAE----KDEEIDQLKRNHIR 1598
Query: 1100 IL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1158
I+ ++Q+ L + LKK + G + ++ +L R + + +L
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-- 1656
Query: 1159 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
K++ + L + L+ +E ++++ ++ E + E+ +L++ ++ T+++ +K+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELRATLEQTERS-RKI 1707
Query: 1219 ETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDE 1274
+E++D S+ T + + +KL + + + E++ +E +A++K A +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767
Query: 1275 KELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITE 1323
++ + EQ+ ER K++ T+ +LQ R+ E+ KQI+ + ++ E
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827
Query: 1324 LLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQ 1369
L +VE R +A+ GL +LTY + K R L+D LQ +VKS ++Q
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887
Query: 1370 LADADRQHQEVIAIYR--THLLSAAQGHMD 1397
+A+ Q +A +R H L A+ D
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Score = 143 bits (360), Expect = 1e-33
Identities = 221/1027 (21%), Positives = 446/1027 (43%), Gaps = 123/1027 (11%)
Query: 283 EVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILL--------------DKVNGL- 327
+V + H E++ +++L E L E + K+ +E++ L DKVN L
Sbjct: 969 KVEKEKHATENK-VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 328 --QLQLNEEVMVADDLESEREKLKSL----------LAAKEKQHEESLRTIEALKNRF-- 373
+++L ++V DDLE E+ K L L K +ES+ IE K +
Sbjct: 1028 KAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 374 ----KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS 429
K FE +L S L K+ + A + I A SR+
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 430 LPSQTSYSENEILKKELEAMRTFCESAKQ---DRLKLQNELAHKVAECKALALECERVKE 486
L S+ +E L++ A E K+ + K++ +L + +A A +
Sbjct: 1145 L-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203
Query: 487 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 546
DS ++ + D L+ V++++ + + ++K M+ LA S+A ++ L+DQL
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
+LK K E + L Q + + EF R ++E + L +LS ++
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LDEKEALVSQLS---RGKQAFT 1315
Query: 607 RKVTEMEGQ-AKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 665
+++ E++ Q +E+ AK AL+ + + L + E+ + E++R K+ +E+
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 666 QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 725
Q + + E + + EE E+ K +L Q+ + + + K +L+K ++
Sbjct: 1376 QWRTKYETDAIQ-----RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---- 1426
Query: 726 NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 785
L+ + +L ++++ + +++ D I L + QK E E+E
Sbjct: 1427 ---LQNEVEDLMLDVERTNAACAALDKKQRNFDKI-------LAEWKQKCEETHAELEAS 1476
Query: 786 LLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 845
E SL ++ +++ + E+ ++ LK L++++S+L ++ E ++IH L
Sbjct: 1477 QKEARSLGTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL- 1532
Query: 846 SENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 904
+KK + + ++ EE + +L K R L++ + +++++ + ++
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 905 EILKRN----LENTQNQIKAEYIS-------LAEHEAKMSSLSQSMRKVQDSNAEILANY 953
+ LKRN +E+ Q+ + AE S + E ++ + + AE L NY
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649
Query: 954 RKGQ----EEIVTLHAEIKAQ---KKELDTIQECIKVKYAPI----VSFEECERKFKATE 1002
R Q + + L +++Q K++L ++ + A I + E+ ER K E
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709
Query: 1003 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
+EL D SE+ Q + K+ KL+ +I +Q ++ D +L E + E+A
Sbjct: 1710 QELLD-ASERVQLLHTQNTSLINTKK---KLETDISQMQGEMED--ILQEARNAEEKAKK 1763
Query: 1063 RKTD------ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1116
TD EL K+ +D S +K E+ V++ + E A Q L+ +++
Sbjct: 1764 AITDAAMMAEELKKE-QDTSAHLERMKKNMEQTVKDLQLRLDE--AEQLALKGGKKQIQK 1820
Query: 1117 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL-HQLLENQKNSSVPLAEHLQIKEA 1175
+EA + L G +E+ ++ + K ++ V +L +Q E++KN + + +
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN----ILRLQDLVDK 1876
Query: 1176 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1235
+ +V K E EE+S + + KLQ E++ ++ E++ ++K + +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSRE 1932
Query: 1236 LETQISS 1242
+ T++ S
Sbjct: 1933 VHTKVIS 1939
Score = 127 bits (320), Expect = 6e-29
Identities = 187/905 (20%), Positives = 381/905 (42%), Gaps = 147/905 (16%)
Query: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 642
K + ++ +KE++ + E +K ++ + E + KEL K+ + K+ L +
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE------KNDLQLQ 896
Query: 643 VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 702
V +A+ L + E ++ + QL+ +++ V + E+ E++ + L K +L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA------EDEEEINAELTAKKRKLE 950
Query: 703 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 762
+ +EL +K+I+ + L ++++ H ++KN ++E+M A +D
Sbjct: 951 DECSEL-------KKDIDDLELTLAKVEKEKHATENKVKN------LTEEM-----AGLD 992
Query: 763 DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVE 822
+ KL EKK E D L + ++ T+ K E+++ L+ ++ +
Sbjct: 993 ETIAKLT------KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046
Query: 823 LKK---QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 879
KK L K+K D + L E+ + E K L++ L K
Sbjct: 1047 EKKLRMDLERAKRKLEGDLK----LAQES-------------IMDIENEKQQLDEKLKKK 1089
Query: 880 NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 939
E+ +++ K ED ++++ K + L+ +E + +I+AE S A+ E + S LS+ +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 940 RKVQD--------SNAEILANYRKGQE--------EIVTLHAEIKA---QKKELDTIQEC 980
++ + ++A+I N ++ E E TL E A +KK D++ E
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209
Query: 981 --------------------IKVKYAPIVSFEECERKFKATEKE----LKDQLSEQTQKY 1016
+K++ + S E K K ++ L+DQLSE K
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-- 1074
+ + + +L+ E + L +K L+ + ++A +++ +EL +QL++
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 1075 -------------------LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-L 1114
L ++Y E + K +L +K +E+ + + +
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 1115 EQVEALKKSLNGTIENLKEELKSMQ-RCYEKE---QQTVTKLHQLLENQKNSSVPLAEHL 1170
E++E KK L ++ +E ++++ +C E Q+ ++ L+ + + ++ A
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 1171 QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1230
+ + F+K + K E E + +E L +E+ K A ++ + L K
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE----SLDQLETLK 1505
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
+L+ +IS L E++A ++ E L KK++ + EK L ++E+ +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKCELQAALEEAEASLE 1558
Query: 1291 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1350
K L EL + E ++I KD +I +L + R+ +++ S N
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618
Query: 1351 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQE 1402
R L ++ + +E QL A+R E + YR +L Q H+D ED++E
Sbjct: 1619 R---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 1403 ALLQI 1407
L +
Sbjct: 1676 QLAMV 1680
Score = 78.6 bits (192), Expect = 4e-14
Identities = 134/795 (16%), Positives = 315/795 (39%), Gaps = 50/795 (6%)
Query: 213 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSL 272
RD E +++ A + L DS A +G+ +D L +K E ++ +
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 273 QQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN 332
++ + + E Q + +L+ + E+ + + + ++ L + QL+
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 333 EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 392
E+ + L ++ + ++Q EE ++ AL + + D + +E
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 452
Q + A+++ ++ ++ R EL + + ++ +EA+
Sbjct: 1359 SKAELQRALSKANTEVAQ--WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416
Query: 453 CESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYES 509
C S ++ + +LQNE+ + + + C ++ + + D+ + + + ++ + S
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 510 EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
+ + + + T +K EE DQL+ LK + + E+ L QI +
Sbjct: 1477 QKEARSLGTELFKIKNAY------------EESLDQLETLKRENKNLQQEISDLTEQIAE 1524
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA 629
+ E ++ + ++ +E LQ L E E + K+ ++ + ++ +++ I A
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-A 1583
Query: 630 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ 689
EK E + N + ++ E IR LK+++E ++ +
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMA 1642
Query: 690 VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKV 749
++ ++ + K T++ L + +E K L +++ +A+ L E++ L+
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL--AMVERRANLLQAEIEELRATLEQ 1700
Query: 750 SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH 809
+E +K + ++LLD +++ ++ L +N SL +LET +
Sbjct: 1701 TERSRKIAE-------QELLDASER-------VQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 810 EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY--VPVKTHEE 867
++I+ N E K+ E+ +K ++ +KK M + ++ E
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 868 VKMTLN------DTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 921
++ L L REL + + N E VK K+E + L + +
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 922 YISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 977
+ L + +AK+ S + + ++ + LA +RK Q E+ + +++ +
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Query: 978 QECIKVKYAPIVSFE 992
+ + + ++S E
Sbjct: 1927 RVKSREVHTKVISEE 1941
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 170 bits (430), Expect = 1e-41
Identities = 247/1063 (23%), Positives = 463/1063 (43%), Gaps = 171/1063 (16%)
Query: 443 KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 502
K +LEA +D ++ EL A+ + L EC +K+D D+ LE L V
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 968
Query: 503 QKRMYESEGKVKQMQTHFLALKE---HLTSE--AASGNHRLT-------EELKDQLKDLK 550
+K + +E KVK + L E LT E A H+ T E+ + L K
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 551 VKYEGASAEVGKLRNQIKQNEMIVEEFKR------------------DEGKLIEENKRLQ 592
+K E ++ Q K+ M +E KR D+ +L E+ K+ +
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088
Query: 593 KELSMCEMEREKKGRKVTEMEGQAKELSAK---LALSIPAE-----KFENMKSSLSNEVN 644
E+S + + E + +++ + KEL A+ L I AE K E +S LS E+
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 645 EKAKKL----------VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 694
E +++L +EM ++ E +E ++++R+LE +HE + L
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAATL 1196
Query: 695 EQKSG----ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
+K ELG++I L Q L+KE ++ ++ L ++ N +
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRAL 1256
Query: 751 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM---EKLLLENDSLSKDVSRLETVFVPPE 807
ED ++ R + D+T + + E + L E D+L +SR + F
Sbjct: 1257 EDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT--- 1313
Query: 808 KHEKEIIALKSNIVELKKQLSE-LKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 866
I ELK+QL E +K K HAL S + ++ QY + +
Sbjct: 1314 ----------QQIEELKRQLEEEIKAKSA----LAHALQSSRHDCD-LLREQY---EEEQ 1355
Query: 867 EVKMTLNDTLAKTNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 925
E K L ++K N E+ + K+E D Q ++++ + L + L++ + ++A
Sbjct: 1356 EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415
Query: 926 AEHEAKMSSLSQS----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIK 968
A E L M V+ +NA +ILA +++ EE HAE++
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELE 1472
Query: 969 AQKKELDTIQ-ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1027
A +KE ++ E K+K A S ++ E K K L+ ++S+ T++ + E K
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIA----EGGKRI 1527
Query: 1028 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA-LSRKTDELNKQLKDLSQKYTEVKNVK 1086
E +K+KK++ + +L+ E S E E + R ELN+ ++ +K E K
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE----K 1583
Query: 1087 EKLVEENAKQTSEIL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKE 1145
++ +++ + I+ ++Q+ L + LKK + G + ++ +L R +
Sbjct: 1584 DEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643
Query: 1146 QQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQ 1205
+ +L K++ + L + L+ +E ++++ ++ E + E+ +L+
Sbjct: 1644 LRNYRNTQAIL---KDTQLHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELR 1693
Query: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEV 1261
+ ++ T+++ +K+ +E++D S+ T + + +KL + + + E++ +E
Sbjct: 1694 ATLEQTERS-RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEA 1752
Query: 1262 LHAKKKEISAKDEKELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA------- 1311
+A++K A + ++ + EQ+ ER K+L T+ +LQ R+ E+
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 1312 -KQIEAKDNKITELLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLI 1356
KQI+ + ++ EL +VE R +A+ GL +LTY + K R L+
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLV 1872
Query: 1357 DTLQHQVKSLEQQLADADRQHQEVIAIYR--THLLSAAQGHMD 1397
D LQ +VKS ++Q +A+ Q ++ +R H L A+ D
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERAD 1915
Score = 149 bits (377), Expect = 1e-35
Identities = 202/1028 (19%), Positives = 448/1028 (43%), Gaps = 112/1028 (10%)
Query: 244 DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 299
D+L+ LTL K E NK + L ++ L + +++ K+ Q HQ + DL
Sbjct: 959 DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLDDL 1014
Query: 300 EIENEDLKERLR-KIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ 358
+ E + + + KI+ EQ+ V+ L+ L +E + DLE + KL+ L ++
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQ-----VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 359 HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQ 418
+ + L + K E + G S + E L Q Q + + Q + ++
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIED--EQALGMQLQKKIKELQARIEELEEEIE 1127
Query: 419 SRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL------KLQNELAHKVA 472
+ R S S EI ++ EA + ++ K++ +L
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 473 ECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA 532
+ +A A + DS ++ + D L+ V++++ + + ++K M+ LA S+A
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNMETVSKAK 1246
Query: 533 SGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 592
++ L+DQL ++K K E E +L N + ++ + + ++E L
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEE----EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302
Query: 593 KELSMCEMEREKKGRKVTEMEGQAKE-LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLV 651
+LS ++ +++ E++ Q +E + AK AL+ + + L + E+ +
Sbjct: 1303 SQLSR---GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 652 EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 711
E++R K+ SE+ Q + + E + + EE E+ K +L Q+ + + + + K
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 712 NQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV 771
+L+K ++ L+ + +L I+++ + +++ D I L +
Sbjct: 1415 CASLEKTKQR-------LQNEVEDLMIDVERTNAACAALDKKQRNFDKI-------LAEW 1460
Query: 772 TQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELK 831
QK E E+E E+ SLS ++ +++ + E+ ++ LK L++++S+L
Sbjct: 1461 KQKCEETHAELEASQKESRSLSTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLT 1517
Query: 832 KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 891
++ E ++IH L +++ S + EE + +L K R L++ +
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAAL---EEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 892 DINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAEH-------EAKMSSLSQSMR 940
+++++ + ++ + +KRN +E+ Q+ + AE S + E ++ + +
Sbjct: 1575 EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1634
Query: 941 KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKA 1000
AE L NYR Q A +K + LD
Sbjct: 1635 HANRMAAEALRNYRNTQ-------AILKDTQLHLDDALR--------------------- 1666
Query: 1001 TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA 1060
++++LK+QL+ ++ ++ + E+++ + ++ ++ +++L D + ++ H +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 1061 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1120
L +L + + + ++ E+ K ++ + L+K+ +E +
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 1121 KKSLNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQI 1172
KK+L T+++L+ LK ++ +K + V +L +E+++ +V + L+
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRK 1846
Query: 1173 KEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
E KE+ + EE+ +N + + V KLQ++V++ K+ ++ E + V+LSK+
Sbjct: 1847 HERKVKEL------TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKF 1900
Query: 1230 KATKSDLE 1237
+ + +LE
Sbjct: 1901 RRIQHELE 1908
Score = 135 bits (341), Expect = 2e-31
Identities = 206/910 (22%), Positives = 384/910 (42%), Gaps = 157/910 (17%)
Query: 583 KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK----------LALSIPAE-- 630
K + ++ +KE++ + E EK ++ + E + KEL K L L + AE
Sbjct: 841 KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 631 -------------KFENMKSSLSNEVNEKAKKLVEMERE----HEKSLSEIRQLKRELEN 673
K + + EV E+A+ E+ E K E +LK+++++
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960
Query: 674 VKAKLAQHVKPEEH---EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLK 730
++ LA+ V+ E+H +VK+ E+ +G L + I +LT + + LQ+ ++ D + +
Sbjct: 961 LELTLAK-VEKEKHATENKVKNLTEEMAG-LDETIAKLTKEKKALQEAHQQTLDDLQAEE 1018
Query: 731 EQAHNLT----------------------IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 768
++ + LT I M K+ D+K + ++ +D N K
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK- 1077
Query: 769 LDVTQKYTEKKLEMEKL--LLEND-----SLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
+ +K +K+ EM L +E++ L K + L+ E+ E+EI A +++
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI---EELEEEIEAERASRA 1134
Query: 822 ELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878
+ +KQ S+L ++ E E++ TS + K ++ ++ E ++ A
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
T ++KK D E + D + +K+ LE ++++K E LA + +S +
Sbjct: 1195 T------LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248
Query: 939 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 998
+ K+ + + L+ + +EE L ++ AQ+ L T E E
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQT---------------ESGEYSR 1293
Query: 999 KATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI-FTLQKDLRDKTVLIEK--- 1053
+ EK+ L QLS Q ++ EE+K+ +E K K + LQ D +L E+
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 1054 ----SHEMERALSRKTDEL----NKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQN 1105
E++RA+S+ E+ K D Q+ E++ K+KL +
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR------------- 1400
Query: 1106 LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVP 1165
LQ +E V A SL T + L+ E++ + E+ L + Q+N
Sbjct: 1401 -LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD---KKQRNFDKI 1456
Query: 1166 LAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD 1225
LAE Q E A L ++ES++ E+ K+++ + ++L +LET
Sbjct: 1457 LAEWKQKCEE-------THAELEASQKESRSLSTELFKIKNAYE---ESLDQLET----- 1501
Query: 1226 LSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQE 1285
K +L+ +IS L E++A ++ E L KK++ + EK L ++E+
Sbjct: 1502 ---LKRENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKSELQAALEEA 1551
Query: 1286 IKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTS 1345
+ K L EL + E ++I KD +I ++ + R+ +++ S
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 1346 GNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------ 1397
N R L ++ + +E QL A+R E + YR +L Q H+D
Sbjct: 1612 RNDAIR---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668
Query: 1398 EDVQEALLQI 1407
ED++E L +
Sbjct: 1669 EDLKEQLAMV 1678
Score = 83.2 bits (204), Expect = 2e-15
Identities = 103/530 (19%), Positives = 224/530 (42%), Gaps = 82/530 (15%)
Query: 885 DVKKKFEDINQ------EFVKIKDKNEILKRNLENTQNQ---------IKAEYISLAEHE 929
D K++++ +N +F+ K +E L +++ Q KA + L E E
Sbjct: 721 DFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLE-E 779
Query: 930 AKMSSLSQSMRKVQDSNAEILAN--YRK---GQEEIVTLHAEIKA--QKKELDTIQECIK 982
+ L+Q + + Q LA Y+K +E I + ++A K ++ K
Sbjct: 780 MRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFK 839
Query: 983 VKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQK 1042
+K P++ E TEKE+ + E + ++EE+ K + + +L++++ TL +
Sbjct: 840 IK--PLLKSAE-------TEKEMANMKEE----FEKTKEELAKTEAKRKELEEKMVTLMQ 886
Query: 1043 DLRDKTVLIEKSHEMERALSRKTDELNK-------QLKDLSQKYTEVKNVKEKLVEENAK 1095
+ D + ++ + + D+L K ++K+++++ + + + +L + K
Sbjct: 887 EKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946
Query: 1096 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1155
E ++ + + L +VE K + ++NL EE+ + +T+ KL +
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-------DETIAKLTKE 999
Query: 1156 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQAL 1215
+ + + + LQ +E + K L ++ ++ + +E+ K++ +++ K+ L
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL 1059
Query: 1216 KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1275
+ DL + + D+E L+EKL KKKE
Sbjct: 1060 EG-------DLKLAQESTMDIENDKQQLDEKL-----------------KKKEFEMS--- 1092
Query: 1276 ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335
++ +I+D++ + I ELQ RI+E ++IEA+ + L + L
Sbjct: 1093 -----GLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 1336 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
+S+ +G T Q ++ + + + + + L +A QH+ A R
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/376 (20%), Positives = 158/376 (42%), Gaps = 54/376 (14%)
Query: 275 RNLTHMQDEVNV--KSHQREHQNIQ---DLEIENEDLKERLRKIQQEQRILLDKVNGLQL 329
R + +E++ ++H R +++Q D EI + + RL+K + +N +++
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD------LNEMEI 1631
Query: 330 QLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSN 389
QLN +A + +++L + +++LR+ E LK + E
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE------------ 1679
Query: 390 RKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP--LELSLPSQTSYSENEIL---KK 444
R+ ++L + + A + T +SR + L+ S Q +++N L KK
Sbjct: 1680 RRANLLQAEIEELRATLEQTE-------RSRKIAEQELLDASERVQLLHTQNTSLINTKK 1732
Query: 445 ELEAMRTFCESAKQDRLKLQNELAHKVAECKA-LALECERVKEDSDEQI------KQLED 497
+LE + + +D ++ K + A+ E +K++ D K LE
Sbjct: 1733 KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Query: 498 ALKDVQKRMYESE-----GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QL 546
+KD+Q R+ E+E G KQ+Q ++E L E S R E +K ++
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE-LEGEVESEQKRNVEAVKGLRKHERKV 1851
Query: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 606
K+L + E + +L++ + + + V+ +KR + E++ + + E E+
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 607 RKVTEMEGQAKELSAK 622
+ E Q +L K
Sbjct: 1912 ERADIAESQVNKLRVK 1927
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 166 bits (421), Expect = 1e-40
Identities = 263/1182 (22%), Positives = 505/1182 (42%), Gaps = 180/1182 (15%)
Query: 263 RELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLD 322
R K P LQ +T ++E+ K + + ++E E L+E RK QQ LL+
Sbjct: 836 RVFTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQ----LLE 887
Query: 323 KVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL----KNRFKYFES 378
+ N L QL E +L +E E++++ LAAK+++ EE L +E+ + R + ++
Sbjct: 888 EKNILAEQLQAET----ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQN 943
Query: 379 DHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSE 438
+ +H + +E + ++G A + + A + + M + L L Q S
Sbjct: 944 EKKKMQAHIQDLEEQLDEEEG----ARQKLQLEKVTAEAKIKKMEEEI-LLLEDQNSKFI 998
Query: 439 NEILKKELEAMRTFC-------ESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQ 491
E KK +E C E ++ K++N+ +++ + + E+ +++ ++
Sbjct: 999 KE--KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 492 IKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNH---------RLTEEL 542
++L+ D+Q ++ E + ++ +++ +E L A G+ ++ EL
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 543 KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-----EGKLIEENKRLQKELSM 597
+ Q+ +L+ +E A K Q + +E K + + ++ R ++E +
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 598 CEM----EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
E+ E E K + + + + +A LS E+ + K++L EK K+ +E
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL-----EKNKQGLET 1231
Query: 654 E-REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKN 712
+ +E + ++Q+K E E+ + KL V+ L K E + EL K
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQ---------ELHAKVSEGDRLRVELAEKA 1282
Query: 713 QTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVT 772
LQ E++ V L E+A I+ L E + ++ + R+ L+++
Sbjct: 1283 SKLQNELDNV----STLLEEAEKKGIKFAKDAASL---ESQLQDTQELLQEETRQKLNLS 1335
Query: 773 QKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKK 832
+ ++LE EK L+ ++ +R + EK+++AL+S QL++ KK
Sbjct: 1336 SRI--RQLEEEKNSLQEQQEEEEEAR--------KNLEKQVLALQS-------QLADTKK 1378
Query: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
K +D I +L KK + + E K D L KT L +++ +D
Sbjct: 1379 KVDDDLGTIESLEEA----KKKLLKDAEALSQRLEEKALAYDKLEKTKNRL---QQELDD 1431
Query: 893 INQEFVKIKDKNEILKRNLENTQ---NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI 949
+ + D + NLE Q +Q+ AE S++ A+ +++ + +++ A
Sbjct: 1432 LTVDL----DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 950 LANYRKGQEEIVTLHAEIKAQKKELDT-IQECIKVKYAPIVSFEECERKFKATEK---EL 1005
LA + EE + E + Q K+L +++ + K + E E+ +A E+ E+
Sbjct: 1488 LA---RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Query: 1006 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMER 1059
+ QL E + +E+ K + N + K F RD K +LI++ E+E
Sbjct: 1545 RTQLEELEDELQATED-AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603
Query: 1060 AL------------SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL 1107
L S+K E++ LKDL + +++++++ K +++ Q L
Sbjct: 1604 ELEDERKQRALAVASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 1108 QKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1160
++ +++ E KSL I L+EEL S +R +Q +L + N
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 1161 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME-----------EVSKLQSEV- 1208
+ L + K E + A L E+ EE Q+ ME +V L +E+
Sbjct: 1722 SGKSALLDE---KRRLEARI----AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 1209 ---------QNTKQALK--------KLETREVVDLSKYKATKSDLETQISSLNEKLANLN 1251
N +Q L+ KL+ E SK+KAT S LE +I L E+L
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 1252 RKYEEVCEEVLHAKKK--EISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1309
++ + V +KK EI + E E H + K+Q E K+ + +L+R+++E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRH---ADQYKEQME---KANARMKQLKRQLEE 1888
Query: 1310 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKR 1351
+ ++ + +L +++ +A GLS+ T N +R
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 150 bits (380), Expect = 6e-36
Identities = 213/993 (21%), Positives = 409/993 (41%), Gaps = 133/993 (13%)
Query: 445 ELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQK 504
ELE M E Q L+ +N LA ++ L E E ++ + ++LE+ L D++
Sbjct: 874 ELEEM----ERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929
Query: 505 RMYESE-------GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS 557
R+ E E + K+MQ H L+E L E + E++ + K K++ E
Sbjct: 930 RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989
Query: 558 AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK--------RLQKELSMCEMEREKKGRKV 609
E + IK+ +++ + +L EE + R ++E+ + ++E K +
Sbjct: 990 LE-DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 610 TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMERE--------HEKSL 661
T E + AK L ++ + L +++E +L + E E +++L
Sbjct: 1049 TRQELE----KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETL 1104
Query: 662 SEIRQLK--RELENVKAKLAQHVKPEEHEQVKSRLEQK--SGELGKKITEL--TLKNQTL 715
+ LK REL+ A+L + + E+ + K+ +++ S EL TEL TL
Sbjct: 1105 HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA 1164
Query: 716 QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Q+E L+ + E+K K E+ K+H+A I D+ ++ ++
Sbjct: 1165 QQE----------LRTKREQEVAELK------KALEEETKNHEAQIQDMRQRHATALEEL 1208
Query: 776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 835
+E +LE K N L K+ LET KE+ + ++K + +KK
Sbjct: 1209 SE-QLEQAKRFKAN--LEKNKQGLET-------DNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 836 EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 895
+++HA SE + +++ L + +K EL +V E+ +
Sbjct: 1259 AQVQELHAKVSEG-----------------DRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 896 EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 955
+ +K L+ L++TQ ++ E +++ L + +Q+ E +
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 956 GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK 1015
+++++ L +++ KK++D I S EE ++K + L +L E+
Sbjct: 1362 LEKQVLALQSQLADTKKKVDD-------DLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 1016 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT---DELNKQL 1072
Y DKL+K LQ++L D TV ++ ++ L +K D+L +
Sbjct: 1415 Y--------------DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 1073 KDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLK 1132
K +S +Y E ++ E E K+T + L++ L++ E+ E K L +E+L
Sbjct: 1461 KSISARYAEERDRAE--AEAREKET-KALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 1133 EELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE----AFEKEVGIIKA--- 1185
+ + + +++ L Q +E + L + LQ E E + +KA
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 1186 -SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1244
L+ ++E+++ K + K E++ + +K V K + DLE QI + N
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 1245 E----------KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCD 1294
+ KL + Y+ EE ++ + + E E S+E EI +E
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 1295 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL------SQLTYTSGNP 1348
S ++ E A +I + + LL++ RL+ + L Q N
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1349 TKRQSQL-IDTLQHQVKSLEQQLADADRQHQEV 1380
R++ L +DTL ++ + +D Q++
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Score = 146 bits (368), Expect = 2e-34
Identities = 221/1087 (20%), Positives = 453/1087 (41%), Gaps = 142/1087 (13%)
Query: 290 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKL- 348
Q + + DLE E+ +ER + +Q E++ + + L+ QL+EE E R+KL
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-------EGARQKLQ 970
Query: 349 --KSLLAAKEKQHEESLRTIEALKNRF----KYFESDHLGSGSHFSNRKEDM-----LLK 397
K AK K+ EE + +E ++F K E S + +E +
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 398 QGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEIL--------------K 443
+ ++ ++D + + ++R L + L +T+ +++I K
Sbjct: 1031 KQEVMISDLE---ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Query: 444 KELEAMRTFCESA-----KQDRLKLQNELAHKVAEC-------KALALECERVKEDSDEQ 491
KE E K + LK+ EL ++AE KA + E+ K D E+
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 492 IKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV 551
++ L+ L+D + + + LK+ L E T+ + Q++D++
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--------TKNHEAQIQDMRQ 1199
Query: 552 KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTE 611
++ A E L Q++Q + ++++ L +NK L E+ + + + + K +
Sbjct: 1200 RHATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 612 MEGQAKELSAKLA--------LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREH---EKS 660
++ Q +EL AK++ L+ A K +N ++S + E KK ++ ++ E
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 661 LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE---LTLKNQTLQK 717
L + ++L +E K L+ ++ E E+ + +Q+ E +K E L L++Q
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 718 E---------IEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 768
+ IE + K L + A L+ ++ + E K +DDL L
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 769 ---LDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALK-----SNI 820
V +K+ + ++LL E S+S + E E EKE AL
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRAEAEAREKETKALSLARALEEA 1495
Query: 821 VELKKQLSELKKKCGEDQE-----------KIHALTSENTNLKKMMSNQYVPVKTHEEVK 869
+E K++ K+ D E +H L L++ + ++ E+
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 870 MTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 929
D + + +K +FE ++ ++NE KR L +++AE E E
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFE---RDLQTRDEQNEEKKRLLIKQVRELEAEL----EDE 1608
Query: 930 AKMSSLSQSMRK-----VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT-IQECIKV 983
K +L+ + +K ++D A+I A K ++E++ +++AQ K+ ++E
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAA-NKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 984 KYAPIVSFEECERKFKATEKE---LKDQL--SEQTQKYSVSEEEVKKNK----------- 1027
+ +E E+K K+ E E L+++L SE+ ++++ E + ++
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 1028 -QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK 1086
E +L+ I L+++L ++ +E ++ R + + D LN +L + N +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 1087 EKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQ 1146
++L +N + +++ ++ ++ + + AL+ + E L++E K + +
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKAT--ISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 1147 QTVTKLHQL---LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1203
+T KL ++ +E+++ + E ++ A K+ +K L E EEE+ K
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ---LKRQLEEAEEEATRANASRRK 1902
Query: 1204 LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLH 1263
LQ E+ + +A + L +REV L + S + +L E+ ++
Sbjct: 1903 LQRELDDATEANEGL-SREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTE 1961
Query: 1264 AKKKEIS 1270
+K +++
Sbjct: 1962 SKTSDVN 1968
Score = 130 bits (328), Expect = 7e-30
Identities = 178/929 (19%), Positives = 402/929 (43%), Gaps = 123/929 (13%)
Query: 545 QLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 604
Q ++L+ K E E+ K++ + + E +EE +R +L+EE L ++L
Sbjct: 850 QEEELQAKDE----ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL--------- 896
Query: 605 KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 664
+ TE+ +A+E+ A+LA ++ E + L + V E+ ++ ++ E +K + I
Sbjct: 897 --QAETELFAEAEEMRARLAAK--KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 665 RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 724
+ L+ +L+ EE + K +LE+ + E KI ++ + L+ + K
Sbjct: 953 QDLEEQLDE-----------EEGARQKLQLEKVTAEA--KIKKMEEEILLLEDQNSKFIK 999
Query: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
+ KL++++ + ++ K ++ + +I DL +L ++ T ++LE K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEKAK 1057
Query: 785 LLLEN------DSLSKDVSRLETVFVPPEKHEKEIIAL----------KSNIVELKKQLS 828
L+ D +++ ++++ + + K E+E+ K+N +++ ++L
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 829 ELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA------KTNRE 882
+ ED E A ++ K+ +S + +KT E++ TL+ T A K +E
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT--ELEDTLDTTAAQQELRTKREQE 1175
Query: 883 LLDVKKKFEDINQEF-VKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRK 941
+ ++KK E+ + +I+D + LE Q++ A E L ++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 942 V-------QDSNAEILANYRKGQEEIVTLHAEI------------KAQK--KELDTIQEC 980
+ Q AE +K ++ LHA++ KA K ELD +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 981 IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1040
++ + F + ++ ++ ++ L E+T++ +++ ++E + L+++
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ--- 1352
Query: 1041 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI 1100
E+ E + L ++ L QL D +K + E L E K +
Sbjct: 1353 -----------EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 1101 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1160
A+ L+++ + +++E K L +++L +L ++ ++ K QLL +K
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461
Query: 1161 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1220
+ S AE EA +E SL EE+ EE + +++ + L +
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 1221 REVVDLSKYKATKSDLETQISSLNEKLANLNRKYE---------EVCEEVLHAK-KKEIS 1270
++ + + +K LE Q+ + +L L + + EV + + A+ ++++
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 1271 AKDE-----KELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1322
+DE K LL + E E++D++++ ++ + +++ +++ QIEA +
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARD 1641
Query: 1323 ELLNDVERLKQALNGLS-QLTYTSGN------PTKRQSQLIDTLQHQVKSLEQQLADADR 1375
E++ + +L+ + +L + +K + + +L+ ++ L+++LA ++R
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 1376 ------QHQEVIAIYRTHLLSAAQGHMDE 1398
Q ++ +A T+ S +DE
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDE 1730
Score = 108 bits (270), Expect = 4e-23
Identities = 142/689 (20%), Positives = 310/689 (44%), Gaps = 85/689 (12%)
Query: 692 SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSE 751
+R E++ +++ ++ K ++ E+E++ ++ L E+ + L +++ +E
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 752 DMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEK 811
+M+ A +L L D+ + E++ + L E + + LE E+ ++
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE------EQLDE 961
Query: 812 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 871
E A + ++L+K +E K K + +E+I L +N+ K K
Sbjct: 962 EEGARQK--LQLEKVTAEAKIK--KMEEEILLLEDQNSKFIK--------------EKKL 1003
Query: 872 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 931
+ D +A+ + +L + ++K +++ KI++K E++ +LE L + E
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNL----AKIRNKQEVMISDLEE----------RLKKEEKT 1049
Query: 932 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF 991
L ++ RK+ ++ Q++I L A+I K +L +E +++ A
Sbjct: 1050 RQELEKAKRKLDGETTDL-------QDQIAELQAQIDELKLQLAKKEE--ELQGALARGD 1100
Query: 992 EECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDK--LKKEIFTLQKDLRDK 1047
+E K A + +EL+ Q++E + + E+ +NK E K L +E+ L+ +L D
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDF--ESEKASRNKAEKQKRDLSEELEALKTELEDT 1158
Query: 1048 TVLIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEK---LVEENAKQTSEILAV 1103
E+ ++ EL K L++ ++ + ++++++++ +EE ++Q +
Sbjct: 1159 LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRF 1218
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
+ L+K + +E K L ++ L++ + +K V +LH +
Sbjct: 1219 KANLEKNK---QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
V LAE + E+ + L E E++ ++ + L+S++Q+T++ L++ ETR+
Sbjct: 1276 VELAEK---ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE-ETRQ- 1330
Query: 1224 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
K +L ++I L E+ +L + EE ++E EK++L +++
Sbjct: 1331 ---------KLNLSSRIRQLEEEKNSLQEQQEE---------EEEARKNLEKQVL--ALQ 1370
Query: 1284 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1343
++ D K++ D L TI L+ ++ K EA ++ E ++L++ N L Q
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 1344 TSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1372
Q Q+ L+ + K +Q LA+
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Score = 95.1 bits (235), Expect = 4e-19
Identities = 141/657 (21%), Positives = 283/657 (43%), Gaps = 69/657 (10%)
Query: 240 ARIGDNLD-ILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH--QNI 296
+++ + LD + TLL+ A + KG + K SL+ + L Q+ + ++ Q+ + I
Sbjct: 1283 SKLQNELDNVSTLLEEAEK---KGIKFAKDAASLESQ-LQDTQELLQEETRQKLNLSSRI 1338
Query: 297 QDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADD----LESEREKLKSLL 352
+ LE E L+E+ + ++ ++ L +V LQ QL + DD +ES E K LL
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 353 ----AAKEKQHEESLR--TIEALKNRFKY------FESDH---LGSGSHFSNRKEDMLLK 397
A ++ E++L +E KNR + + DH + S +K D LL
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 398 QGQMYMAD-----SQCTSPGIPAHMQSRSMLRPLELSLPSQTSYS-ENEILKKELEAMRT 451
+ + A + + ++ S+ R LE +L ++ + +N+ L+ ++E
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME---- 1514
Query: 452 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 511
D + ++++ V E + E+ E+ Q+++LED L+ + E
Sbjct: 1515 -------DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 512 KVKQMQTHF---LALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 568
++ M+ F L ++ E + EL+ +L+D + + A A K+ +K
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 569 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP 628
E +E + ++I++ ++LQ ++ + E E+ E+ Q+KE KL S+
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK-SLE 1686
Query: 629 AEKFENMKSSLSNEVNEKAKKLVEMER-----EHEKSLSEIRQLKRELENVKAKLAQHVK 683
AE + + S +E+A++ E ER E S S L E ++A++AQ +
Sbjct: 1687 AEILQLQEELAS---SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 684 PEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNH 743
E EQ L L + + TL+ TL E+ + K +E +N
Sbjct: 1744 ELEEEQSNMEL------LNDRFRKTTLQVDTLNAELAAE--RSAAQKSDNARQQLERQNK 1795
Query: 744 YVPLKVSE---DMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 800
+ K+ E +K A I L K+ + ++ + E ++ N + + +L+
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ---EAKERAAANKLVRRTEKKLK 1852
Query: 801 TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 857
+F+ E + K + + ++ +LK++ E +E+ + L++ + +
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Score = 60.1 bits (144), Expect = 1e-08
Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 56/382 (14%)
Query: 1070 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1129
K L ++++ E++ E+L++ KQT ++ + +K LE+ L + L E
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 1130 NLKEELKSMQRCYEKEQQTVTKLH-------------QLLENQKNSSVPLAEHLQ-IKEA 1175
E + R K+Q+ LH Q+L+N+K + H+Q ++E
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK---MQAHIQDLEEQ 958
Query: 1176 FEKEVGI-IKASLREKEEESQNKMEEVSKLQSEVQNTKQAL-KKLETREVVDLSKYKATK 1233
++E G K L + E++ K E L E QN+K KKL + + S A +
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 1234 SD-----------LETQISSLNEKLANLNRKYEEVCEEVLHAKKK-------------EI 1269
+ E IS L E+L +K E+ +E+ AK+K E+
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERL----KKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074
Query: 1270 SAK-DEKELLHFSIEQEIKDQKERCD-------KSLTTITELQRRIQESAKQIEAKDNKI 1321
A+ DE +L E+E++ R D +L + ELQ +I E + E++
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 1322 TELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVI 1381
+ L + L L + + T Q +L + +V L++ L + + H+ I
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 1382 AIYRTHLLSAAQGHMDEDVQEA 1403
R +A + + E +++A
Sbjct: 1195 QDMRQRHATALE-ELSEQLEQA 1215
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 166 bits (420), Expect = 1e-40
Identities = 343/1604 (21%), Positives = 646/1604 (40%), Gaps = 269/1604 (16%)
Query: 6 SRLRRQDVPGPASSGAAAASAHAADWNKYD-DRLMKAAERGDVEKVTSILAKKGVNPGKL 64
+R +R G G A S D ++ KAA G+V KV IL +
Sbjct: 17 ARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDR 76
Query: 65 DVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYN 124
D R+ H+ + G+ E + ++ + D R AL A + C LL++
Sbjct: 77 DKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHG 136
Query: 125 CPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQ 184
AD+ G TALH A + S L + A++ AK+ D TPL+LA + + +
Sbjct: 137 ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVE 196
Query: 185 LLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIK------NGADISLLDAL------ 232
LI + A+VN+ DK + ++ EY E + K N D S D+L
Sbjct: 197 FLIKKKANVNAVDKLESSHQLIS-EY----KEERIPKHSSQNSNSVDESSEDSLSRLSGK 251
Query: 233 -GHDSSYYARIGDNLDI---------LTLLKTASENTNKGRELWKKGPSLQQRNL----- 277
G D S+ ++L+ L L TAS+ + K E R L
Sbjct: 252 PGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRD 311
Query: 278 THMQDEVNVKSHQREHQNIQDLE---IENEDLKER----------LRKIQQEQRILLDKV 324
+ QDEV V+S +Q ++ DL + L K + + + K
Sbjct: 312 SDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKE 371
Query: 325 NG--------LQLQLNEEVMVADDL-ESEREKLKSLLAAKEKQHEESLRTIEALKNRFKY 375
NG L+ N+ + D++ ++ R + S L +++ ES E++ F
Sbjct: 372 NGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQ 431
Query: 376 FESDHL-----GSGSHFSNRK-EDMLLKQGQM------YMADSQCT-SPGIP-AHMQSRS 421
D L G + N + ED+ M MA + T + G+P AHM+S
Sbjct: 432 KYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPE 491
Query: 422 MLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQD-RLKLQNELAHKVAECKALALE 480
L+ ++ + S K+++ + +A+ D + + E + +E +E
Sbjct: 492 RYLHLKPTIEMKDSVPNKAGGMKDVQTSK----AAEHDLEVASEEEQEREGSENNQPQVE 547
Query: 481 CERVKEDSDEQ--IKQLEDALKDVQKRMYESEGKVKQMQT----HFLALKEHLTSEAASG 534
ER K ++E + D D + + +G +++ ++ H ++ A+SG
Sbjct: 548 EERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASSG 607
Query: 535 NHRLTEELKDQLKDLKVKYEGASAEV-GK---LRNQIKQ--NEMIVEEFKRDEGKLI--- 585
+E+K K+ + E ++ V GK L + Q ++ + E DEG+
Sbjct: 608 PALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKT 667
Query: 586 --EENKRLQKELSM----------------CEMEREKKGRKVTEMEGQAKELSAKLAL-- 625
E+NK + SM CE+ + +E E ++L
Sbjct: 668 SNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLK 727
Query: 626 ----SIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---- 677
++ E+ +K + + K KK+ + ++ LSE +++K +LE+ K +
Sbjct: 728 IQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERE 787
Query: 678 ---LAQHVKPEE---------HEQVKSRLEQKSGELGKKI---TELTLKNQTLQKEIEKV 722
L + EE +E+++ +L +K + K++ +L L QTL+ E+ V
Sbjct: 788 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTV 847
Query: 723 YLD-NKLLKEQ---AHNLTIE----------MKNHYVPLKVSEDMKKSHDAIIDDLNRKL 768
+ N++++E+ L+ E + NH K E +K ++ + +
Sbjct: 848 KSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 907
Query: 769 LDVTQKYTEKKLEMEKLLLENDSL-----SKDVSRLETVFVPPEKHEKEIIALKSNIVEL 823
D++ K + + E+ L LE D++ K+ E + + EK+E +K N L
Sbjct: 908 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETL 967
Query: 824 KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA------ 877
+ +S+ ++ LT+EN L + N+ + E + + LA
Sbjct: 968 TQTISQY-------NGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
Query: 878 ----KTNREL-------LDVKKKFED-INQEFVKIKDKNEILKRNLENTQNQIKAEYI-- 923
+ REL D + +D +N + +KD NEIL + L T++++ + I
Sbjct: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
Query: 924 -------------------SLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH 964
L++ + +M + Q + Q + + +E + L
Sbjct: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
Query: 965 AEIKAQKKELDTIQECIKVKYAPIVS----FEECERKFKATEKELKDQLSEQTQKYSVSE 1020
+E +++LD K +++ F +K +A E E + L E+ K +SE
Sbjct: 1141 SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQA-ESEKQSLLLEERNKELISE 1199
Query: 1021 EEVKKNKQ---ENDKLKKEIFT--LQKDLRD---KTVLIEKSHEM-----------ERAL 1061
K +Q EN+K ++E+ LQ++L D K + E S E+ + L
Sbjct: 1200 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDL 1259
Query: 1062 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1121
+K ++ QL++ ++TE EK+ + K + ++ ++KQ ++++E L+
Sbjct: 1260 KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ---MDKIEELQ 1316
Query: 1122 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVG 1181
K+L NL E+ EKEQ L +L+E +++ L + ++ E+E+
Sbjct: 1317 KNLLNA--NLSED--------EKEQ-----LKKLMELKQSLECNLDQEMKKNVELEREIT 1361
Query: 1182 IIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1241
K L+ ++ K+ E + LK + + ++K K DL ++
Sbjct: 1362 GFKNLLK----MTRKKLNEYENGEFSFHGD---LKTSQFEMDIQINKLKHKIDDLTAELE 1414
Query: 1242 SLNEKLANLNRKYEEVCEEVLH----AKKKEISAKDEKELLHFSIEQEIKDQKERCDKS- 1296
+ K +L+ K + + EE+L KK E K++K+L EQE+ + + +++
Sbjct: 1415 TAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL-----EQEVINLRSHIERNM 1469
Query: 1297 --LTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1354
L + + ++ I+E A+Q A+ K L + Q L Q + K Q +
Sbjct: 1470 VELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQ--ENLEQFRENNFASMKSQME 1527
Query: 1355 LIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDE 1398
L ++K LE +L+ ++ +T L Q +++E
Sbjct: 1528 L------RIKDLESELSKIKTSQED---FNKTELEKYKQLYLEE 1562
Score = 37.7 bits (86), Expect = 0.079
Identities = 91/440 (20%), Positives = 166/440 (37%), Gaps = 114/440 (25%)
Query: 286 VKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESER 345
V+ ++ + Q LE +N LK ++K +DK+ LQ L + A+ E E+
Sbjct: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKK-------QMDKIEELQKNL----LNANLSEDEK 1329
Query: 346 EKLKSLLAAKE----------KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDML 395
E+LK L+ K+ K++ E R I KN K RK+
Sbjct: 1330 EQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKM-------------TRKKLNE 1376
Query: 396 LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLE-LSLPSQTSYSE-------NEILKKELE 447
+ G+ TS +Q + ++ L+ +T+ S+ N+IL++EL
Sbjct: 1377 YENGEFSFHGDLKTSQ-FEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELL 1435
Query: 448 AMRTF---CESAKQDRLKLQNE--------------------------------LAHKVA 472
+M+T CE ++++ KL+ E +A K+
Sbjct: 1436 SMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLK 1495
Query: 473 ECKALALECERVKEDSDEQIK---------QLEDALKDVQKRMYESEG-----------K 512
E L L+ + +++ EQ + Q+E +KD++ + + + K
Sbjct: 1496 EVN-LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEK 1554
Query: 513 VKQMQTHFLALKEHLTSEAASGNHRLTE----------ELKDQLKDLKVKYEGASAEVGK 562
KQ+ L +++ L+S+ N RL E + + L + VG
Sbjct: 1555 YKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGN 1614
Query: 563 LRNQIKQNEMIV--EEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL- 619
L N + N ++ E N ++ LS + E EK + E++ A EL
Sbjct: 1615 LNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITR--ELKEAAAELE 1672
Query: 620 SAKLALSIPAEKFENMKSSL 639
S +A + + N+ L
Sbjct: 1673 SGSIASPLGSTDESNLNQDL 1692
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 160 bits (406), Expect = 6e-39
Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)
Query: 267 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326
K P LQ +T ++E+ K + + + + ENE L++++Q+ L ++ N
Sbjct: 840 KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 891
Query: 327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386
LQ QL E +L +E E+++ LAAK+++ EE L +EA + E + G
Sbjct: 892 LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 942
Query: 387 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446
+K + + + + + +L L T+ ++ + L+ E+
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 987
Query: 447 EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 503
M ++R L+ ++L +AE + A ++K + I +LE LK +
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 504 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 559
K E E LK L +A S H +L+ Q+ +LK+ K E A
Sbjct: 1048 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
+ +L ++I Q +++ + EG + + + L E + ++K E+E EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
L + ++ +++ EV K L E R HE + E+RQ
Sbjct: 1156 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1199
Query: 680 QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 739
+H Q L ++ + + L QTL+KE + + ++L + +
Sbjct: 1200 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250
Query: 740 MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
E KK +A + +L K D + E ++ KL E +S++ ++
Sbjct: 1251 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 800 ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 859
E + K K++ +L S + + ++ L E ++ K+ L E +L+ + +
Sbjct: 1300 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 860 VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 909
+ E TLN L+ + ++L D KK+F+ + + ++
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 910 NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 960
LE T+N+++ E + L +S+L + RK AE I + Y + + E
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 961 VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 997
E KA K+EL+ + +K + +VS E+ +R
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 998 FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1039
+ +E+K QL E + +E+ +++ ++N++ +++
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1593
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ+ L + +E + + +L LKDL + +E+ +++ K ++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 1100 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
+ Q L+ +++ E KSL + L+E+L + +R ++ +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 1153 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1201
+ L + + L + Q++E E+E G ++A +R+ ++++ E+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 1202 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1250
+ +S Q + A ++LE + E SK+K+T + LE +I+ L E++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 1251 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1306
R+ + A K + KD+K LL E+++ +Q KE+ +K + +L+R+
Sbjct: 1834 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 1307 IQES---AKQIEAKDNKITELLNDVERLKQAL 1335
++E+ +++I A K+ L++ +A+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 137 bits (344), Expect = 1e-31
Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)
Query: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 545
+E+++ ED L+ ++R ++E ++K+++ + +LTEE L++Q
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 895
Query: 546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 604
L+ Y A AE ++R K+ E+ EE + E +L EE R Q+ + ER+K
Sbjct: 896 LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 947
Query: 605 KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 664
+++ ++E Q +E A +K + K + ++ + +++ M+ ++ K E
Sbjct: 948 MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 665 RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 724
+ L+ + ++ LA EE E+ K+ +T+L K++++ E+E
Sbjct: 1002 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1041
Query: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
+L KE+ +E +K+ + D + ++ D+ + E K+++ K
Sbjct: 1042 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 785 LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 837
+ + L ++RL+ K+I L+ +I +L++ L ++ +K+ +
Sbjct: 1088 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 838 QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 893
E++ AL +E L + Q + K +EV K L++ ++ ++++K
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 949
+E + ++ + K NL+ + ++ E LA + Q + +K++ E+
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 950 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
+ G+ L+ ++ + E++++ + E E K K++
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1314
Query: 1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1069
S+ + +EE ++ + KL++ L+++ +++ E ++ L R LN
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 1070 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1129
QL D +K + + E L E + EI + +++ +++E K L ++
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 1130 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1189
+L +L + ++ ++ K QLL +KN S A+ EA +E SL
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
EE+ EE+ + ++ + L + ++ + + +K LETQ+ + +L
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1548
Query: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1309
EE+ +E+ + ++ + + L E++++ + E+ ++ +LQR++ E
Sbjct: 1549 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1600
Query: 1310 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1369
++E + + ++L+ L L ++ + + + LQ Q+K +++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 1370 LADADRQHQEVIA 1382
L DA E+ A
Sbjct: 1661 LEDARASRDEIFA 1673
Score = 120 bits (300), Expect = 1e-26
Identities = 184/928 (19%), Positives = 372/928 (40%), Gaps = 89/928 (9%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 308
LT LK E+ E+ K ++ L ++ ++ + H+ I DL+ + +LK
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1083
Query: 309 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 361
+L K ++E + L +++ Q N + +LE +E L S AA+ EKQ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 362 SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
+EALK + +S +E +LK+ D + S +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1199
Query: 421 SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 465
+ +E L QT EN L EL + AKQ+ +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1255
Query: 466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 525
+L +V E ++ + ER + + ++++ +L++ ++ V + E+EGK ++ +L
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 526 HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
L T E R L EE L+DQL + + + L Q+
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 628
++ +++F L E KR QKE+ + E+K ++E L +L L +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 629 AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 687
+ + S+L + + + L E + K E + + E + K + EE
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 688 EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 747
+ K LE+ + L ++ +L + K + ++ + L+ Q + +++ L
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 748 KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
+ +ED K + A+ R L ++ EK+ ++++ L E ++ +D + +
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 804 VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
+K E + + E KQL +L+ + + Q ++ + +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 912
K+ E M L + LA R + E++ +E L KR LE
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 913 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 969
Q++ E L E + M ++S +RK ++ LA R ++ + +++
Sbjct: 1736 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 970 QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1025
Q KEL + ++ +K K+ ++ A E ++ QL EQ ++ + ++ K
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1842
Query: 1026 NKQENDKLKKEIFTLQKDLRDKT----VLIEKSHEMERALSRKTDELNKQLKDLSQKYTE 1081
+ ++ DK KEI +D R EK + + L R+ +E ++ + ++ +
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 1082 VKNVKEKLVEENAKQTSEILAVQNLLQK 1109
++ ++ E N E+ A+++ L++
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 94.7 bits (234), Expect = 5e-19
Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)
Query: 984 KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1043
K P++ E + +A E EL+ + E+ QK +E E+K+ +Q++ +L +E LQ+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 895
Query: 1044 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1103
L+ +T L ++ EM L+ K EL + L ++ + E ++ ++L E K ++L +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
+ L+++ ++++ K + I+ L++E+ M + + ++K +LLE +
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1007
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
L A E+E L+ K E +++E +L+ E + ++Q L+KL+ +
Sbjct: 1008 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1061
Query: 1224 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
D S + +DL+ QI+ L +LA K EE + L EI+ K+ +E
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 1284 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1329
I D +E D + +++ ++ +++EA ++ + L+ +V
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 1330 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1378
LK+AL+ ++ + + +Q ++ L Q++ ++ A+ D+ Q
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Score = 81.6 bits (200), Expect = 5e-15
Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)
Query: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
++ E++A++ EL +E + + E+ + + L++QL +T+ Y+
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 1019 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
+EE + KQE L++ L + +E+ + + L + ++ +Q+ DL
Sbjct: 906 AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1076 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1128
++ E + ++KL E K EIL + + K + +E L +
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1176
+E+ K++ + K + +++L L+ ++ S L + H QI +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1074
Query: 1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1230
+ ++ +K L +KEEE Q +++L E+ ALKK+ E DL +
Sbjct: 1075 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
A ++ E Q L E+L L + E+ + A ++E+ AK E+E+ ++ ++ D++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1186
Query: 1291 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
R ++ + E++++ ++E +Q+E L + + L++ L+ G
Sbjct: 1187 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
+ L+ QV+ L+ + +D +R E+
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 160 bits (406), Expect = 6e-39
Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)
Query: 267 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326
K P LQ +T ++E+ K + + + + ENE L++++Q+ L ++ N
Sbjct: 847 KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 898
Query: 327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386
LQ QL E +L +E E+++ LAAK+++ EE L +EA + E + G
Sbjct: 899 LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 949
Query: 387 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446
+K + + + + + +L L T+ ++ + L+ E+
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 994
Query: 447 EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 503
M ++R L+ ++L +AE + A ++K + I +LE LK +
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 504 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 559
K E E LK L +A S H +L+ Q+ +LK+ K E A
Sbjct: 1055 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
+ +L ++I Q +++ + EG + + + L E + ++K E+E EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
L + ++ +++ EV K L E R HE + E+RQ
Sbjct: 1163 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1206
Query: 680 QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 739
+H Q L ++ + + L QTL+KE + + ++L + +
Sbjct: 1207 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257
Query: 740 MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
E KK +A + +L K D + E ++ KL E +S++ ++
Sbjct: 1258 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 800 ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 859
E + K K++ +L S + + ++ L E ++ K+ L E +L+ + +
Sbjct: 1307 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 860 VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 909
+ E TLN L+ + ++L D KK+F+ + + ++
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 910 NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 960
LE T+N+++ E + L +S+L + RK AE I + Y + + E
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 961 VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 997
E KA K+EL+ + +K + +VS E+ +R
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 998 FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1039
+ +E+K QL E + +E+ +++ ++N++ +++
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1600
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ+ L + +E + + +L LKDL + +E+ +++ K ++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 1100 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
+ Q L+ +++ E KSL + L+E+L + +R ++ +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 1153 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1201
+ L + + L + Q++E E+E G ++A +R+ ++++ E+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 1202 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1250
+ +S Q + A ++LE + E SK+K+T + LE +I+ L E++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 1251 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1306
R+ + A K + KD+K LL E+++ +Q KE+ +K + +L+R+
Sbjct: 1841 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 1307 IQES---AKQIEAKDNKITELLNDVERLKQAL 1335
++E+ +++I A K+ L++ +A+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 137 bits (344), Expect = 1e-31
Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)
Query: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 545
+E+++ ED L+ ++R ++E ++K+++ + +LTEE L++Q
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 902
Query: 546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 604
L+ Y A AE ++R K+ E+ EE + E +L EE R Q+ + ER+K
Sbjct: 903 LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 954
Query: 605 KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 664
+++ ++E Q +E A +K + K + ++ + +++ M+ ++ K E
Sbjct: 955 MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 665 RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 724
+ L+ + ++ LA EE E+ K+ +T+L K++++ E+E
Sbjct: 1009 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1048
Query: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
+L KE+ +E +K+ + D + ++ D+ + E K+++ K
Sbjct: 1049 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 785 LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 837
+ + L ++RL+ K+I L+ +I +L++ L ++ +K+ +
Sbjct: 1095 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 838 QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 893
E++ AL +E L + Q + K +EV K L++ ++ ++++K
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 949
+E + ++ + K NL+ + ++ E LA + Q + +K++ E+
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 950 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
+ G+ L+ ++ + E++++ + E E K K++
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1321
Query: 1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1069
S+ + +EE ++ + KL++ L+++ +++ E ++ L R LN
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 1070 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1129
QL D +K + + E L E + EI + +++ +++E K L ++
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 1130 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1189
+L +L + ++ ++ K QLL +KN S A+ EA +E SL
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
EE+ EE+ + ++ + L + ++ + + +K LETQ+ + +L
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1555
Query: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1309
EE+ +E+ + ++ + + L E++++ + E+ ++ +LQR++ E
Sbjct: 1556 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1607
Query: 1310 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1369
++E + + ++L+ L L ++ + + + LQ Q+K +++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 1370 LADADRQHQEVIA 1382
L DA E+ A
Sbjct: 1668 LEDARASRDEIFA 1680
Score = 120 bits (300), Expect = 1e-26
Identities = 184/928 (19%), Positives = 372/928 (40%), Gaps = 89/928 (9%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 308
LT LK E+ E+ K ++ L ++ ++ + H+ I DL+ + +LK
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1090
Query: 309 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 361
+L K ++E + L +++ Q N + +LE +E L S AA+ EKQ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 362 SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
+EALK + +S +E +LK+ D + S +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1206
Query: 421 SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 465
+ +E L QT EN L EL + AKQ+ +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1262
Query: 466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 525
+L +V E ++ + ER + + ++++ +L++ ++ V + E+EGK ++ +L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 526 HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
L T E R L EE L+DQL + + + L Q+
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 628
++ +++F L E KR QKE+ + E+K ++E L +L L +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 629 AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 687
+ + S+L + + + L E + K E + + E + K + EE
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 688 EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 747
+ K LE+ + L ++ +L + K + ++ + L+ Q + +++ L
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 748 KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
+ +ED K + A+ R L ++ EK+ ++++ L E ++ +D + +
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 804 VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
+K E + + E KQL +L+ + + Q ++ + +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 912
K+ E M L + LA R + E++ +E L KR LE
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 913 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 969
Q++ E L E + M ++S +RK ++ LA R ++ + +++
Sbjct: 1743 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 970 QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1025
Q KEL + ++ +K K+ ++ A E ++ QL EQ ++ + ++ K
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1849
Query: 1026 NKQENDKLKKEIFTLQKDLRDKT----VLIEKSHEMERALSRKTDELNKQLKDLSQKYTE 1081
+ ++ DK KEI +D R EK + + L R+ +E ++ + ++ +
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 1082 VKNVKEKLVEENAKQTSEILAVQNLLQK 1109
++ ++ E N E+ A+++ L++
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 94.7 bits (234), Expect = 5e-19
Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)
Query: 984 KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1043
K P++ E + +A E EL+ + E+ QK +E E+K+ +Q++ +L +E LQ+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 902
Query: 1044 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1103
L+ +T L ++ EM L+ K EL + L ++ + E ++ ++L E K ++L +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
+ L+++ ++++ K + I+ L++E+ M + + ++K +LLE +
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1014
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
L A E+E L+ K E +++E +L+ E + ++Q L+KL+ +
Sbjct: 1015 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1068
Query: 1224 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
D S + +DL+ QI+ L +LA K EE + L EI+ K+ +E
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 1284 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1329
I D +E D + +++ ++ +++EA ++ + L+ +V
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 1330 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1378
LK+AL+ ++ + + +Q ++ L Q++ ++ A+ D+ Q
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Score = 81.6 bits (200), Expect = 5e-15
Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)
Query: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
++ E++A++ EL +E + + E+ + + L++QL +T+ Y+
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 1019 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
+EE + KQE L++ L + +E+ + + L + ++ +Q+ DL
Sbjct: 913 AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1076 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1128
++ E + ++KL E K EIL + + K + +E L +
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1176
+E+ K++ + K + +++L L+ ++ S L + H QI +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1081
Query: 1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1230
+ ++ +K L +KEEE Q +++L E+ ALKK+ E DL +
Sbjct: 1082 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
A ++ E Q L E+L L + E+ + A ++E+ AK E+E+ ++ ++ D++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1193
Query: 1291 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
R ++ + E++++ ++E +Q+E L + + L++ L+ G
Sbjct: 1194 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
+ L+ QV+ L+ + +D +R E+
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 160 bits (406), Expect = 6e-39
Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)
Query: 267 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326
K P LQ +T ++E+ K + + + + ENE L++++Q+ L ++ N
Sbjct: 847 KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 898
Query: 327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386
LQ QL E +L +E E+++ LAAK+++ EE L +EA + E + G
Sbjct: 899 LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 949
Query: 387 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446
+K + + + + + +L L T+ ++ + L+ E+
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 994
Query: 447 EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 503
M ++R L+ ++L +AE + A ++K + I +LE LK +
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 504 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 559
K E E LK L +A S H +L+ Q+ +LK+ K E A
Sbjct: 1055 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
+ +L ++I Q +++ + EG + + + L E + ++K E+E EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
L + ++ +++ EV K L E R HE + E+RQ
Sbjct: 1163 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1206
Query: 680 QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 739
+H Q L ++ + + L QTL+KE + + ++L + +
Sbjct: 1207 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257
Query: 740 MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
E KK +A + +L K D + E ++ KL E +S++ ++
Sbjct: 1258 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 800 ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 859
E + K K++ +L S + + ++ L E ++ K+ L E +L+ + +
Sbjct: 1307 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 860 VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 909
+ E TLN L+ + ++L D KK+F+ + + ++
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 910 NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 960
LE T+N+++ E + L +S+L + RK AE I + Y + + E
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 961 VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 997
E KA K+EL+ + +K + +VS E+ +R
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 998 FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1039
+ +E+K QL E + +E+ +++ ++N++ +++
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1600
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ+ L + +E + + +L LKDL + +E+ +++ K ++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 1100 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
+ Q L+ +++ E KSL + L+E+L + +R ++ +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 1153 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1201
+ L + + L + Q++E E+E G ++A +R+ ++++ E+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 1202 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1250
+ +S Q + A ++LE + E SK+K+T + LE +I+ L E++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 1251 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1306
R+ + A K + KD+K LL E+++ +Q KE+ +K + +L+R+
Sbjct: 1841 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 1307 IQES---AKQIEAKDNKITELLNDVERLKQAL 1335
++E+ +++I A K+ L++ +A+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 137 bits (344), Expect = 1e-31
Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)
Query: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 545
+E+++ ED L+ ++R ++E ++K+++ + +LTEE L++Q
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 902
Query: 546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 604
L+ Y A AE ++R K+ E+ EE + E +L EE R Q+ + ER+K
Sbjct: 903 LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 954
Query: 605 KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 664
+++ ++E Q +E A +K + K + ++ + +++ M+ ++ K E
Sbjct: 955 MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 665 RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 724
+ L+ + ++ LA EE E+ K+ +T+L K++++ E+E
Sbjct: 1009 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1048
Query: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
+L KE+ +E +K+ + D + ++ D+ + E K+++ K
Sbjct: 1049 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 785 LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 837
+ + L ++RL+ K+I L+ +I +L++ L ++ +K+ +
Sbjct: 1095 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 838 QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 893
E++ AL +E L + Q + K +EV K L++ ++ ++++K
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 949
+E + ++ + K NL+ + ++ E LA + Q + +K++ E+
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 950 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
+ G+ L+ ++ + E++++ + E E K K++
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1321
Query: 1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1069
S+ + +EE ++ + KL++ L+++ +++ E ++ L R LN
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 1070 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1129
QL D +K + + E L E + EI + +++ +++E K L ++
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 1130 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1189
+L +L + ++ ++ K QLL +KN S A+ EA +E SL
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
EE+ EE+ + ++ + L + ++ + + +K LETQ+ + +L
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1555
Query: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1309
EE+ +E+ + ++ + + L E++++ + E+ ++ +LQR++ E
Sbjct: 1556 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1607
Query: 1310 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1369
++E + + ++L+ L L ++ + + + LQ Q+K +++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 1370 LADADRQHQEVIA 1382
L DA E+ A
Sbjct: 1668 LEDARASRDEIFA 1680
Score = 121 bits (303), Expect = 5e-27
Identities = 189/943 (20%), Positives = 375/943 (39%), Gaps = 102/943 (10%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 308
LT LK E+ E+ K ++ L ++ ++ + H+ I DL+ + +LK
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1090
Query: 309 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 361
+L K ++E + L +++ Q N + +LE +E L S AA+ EKQ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 362 SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
+EALK + +S +E +LK+ D + S +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1206
Query: 421 SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 465
+ +E L QT EN L EL + AKQ+ +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1262
Query: 466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 525
+L +V E ++ + ER + + ++++ +L++ ++ V + E+EGK ++ +L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 526 HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
L T E R L EE L+DQL + + + L Q+
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 628
++ +++F L E KR QKE+ + E+K ++E L +L L +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 629 AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 687
+ + S+L + + + L E + K E + + E + K + EE
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 688 EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 747
+ K LE+ + L ++ +L + K + ++ + L+ Q + +++ L
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 748 KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
+ +ED K + A+ R L ++ EK+ ++++ L E ++ +D + +
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 804 VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
+K E + + E KQL +L+ + + Q ++ + +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 912
K+ E M L + LA R + E++ +E L KR LE
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 913 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 969
Q++ E L E + M ++S +RK ++ LA R ++ + +++
Sbjct: 1743 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 970 QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1025
Q KEL + ++ +K K+ ++ A E ++ QL EQ ++ + ++ K
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1849
Query: 1026 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNV 1085
+ ++ DK KEI + D+ + E+ E + + +L +QL++ ++ +
Sbjct: 1850 SLKQKDKKLKEILL---QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 1086 KEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
+ KL E A +++E + +V ALK L G
Sbjct: 1907 RRKLQRELDEATESNEAMG------------REVNALKSKLRG 1937
Score = 94.7 bits (234), Expect = 5e-19
Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)
Query: 984 KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1043
K P++ E + +A E EL+ + E+ QK +E E+K+ +Q++ +L +E LQ+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 902
Query: 1044 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1103
L+ +T L ++ EM L+ K EL + L ++ + E ++ ++L E K ++L +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
+ L+++ ++++ K + I+ L++E+ M + + ++K +LLE +
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1014
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
L A E+E L+ K E +++E +L+ E + ++Q L+KL+ +
Sbjct: 1015 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1068
Query: 1224 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
D S + +DL+ QI+ L +LA K EE + L EI+ K+ +E
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 1284 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1329
I D +E D + +++ ++ +++EA ++ + L+ +V
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 1330 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1378
LK+AL+ ++ + + +Q ++ L Q++ ++ A+ D+ Q
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Score = 81.6 bits (200), Expect = 5e-15
Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)
Query: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
++ E++A++ EL +E + + E+ + + L++QL +T+ Y+
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 1019 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
+EE + KQE L++ L + +E+ + + L + ++ +Q+ DL
Sbjct: 913 AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1076 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1128
++ E + ++KL E K EIL + + K + +E L +
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1176
+E+ K++ + K + +++L L+ ++ S L + H QI +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1081
Query: 1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1230
+ ++ +K L +KEEE Q +++L E+ ALKK+ E DL +
Sbjct: 1082 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
A ++ E Q L E+L L + E+ + A ++E+ AK E+E+ ++ ++ D++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1193
Query: 1291 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
R ++ + E++++ ++E +Q+E L + + L++ L+ G
Sbjct: 1194 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
+ L+ QV+ L+ + +D +R E+
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 160 bits (406), Expect = 6e-39
Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)
Query: 267 KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326
K P LQ +T ++E+ K + + + + ENE L++++Q+ L ++ N
Sbjct: 840 KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 891
Query: 327 LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386
LQ QL E +L +E E+++ LAAK+++ EE L +EA + E + G
Sbjct: 892 LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 942
Query: 387 FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446
+K + + + + + +L L T+ ++ + L+ E+
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 987
Query: 447 EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 503
M ++R L+ ++L +AE + A ++K + I +LE LK +
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 504 KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 559
K E E LK L +A S H +L+ Q+ +LK+ K E A
Sbjct: 1048 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 560 VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619
+ +L ++I Q +++ + EG + + + L E + ++K E+E EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 620 SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 679
L + ++ +++ EV K L E R HE + E+RQ
Sbjct: 1156 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1199
Query: 680 QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 739
+H Q L ++ + + L QTL+KE + + ++L + +
Sbjct: 1200 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250
Query: 740 MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
E KK +A + +L K D + E ++ KL E +S++ ++
Sbjct: 1251 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 800 ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 859
E + K K++ +L S + + ++ L E ++ K+ L E +L+ + +
Sbjct: 1300 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 860 VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 909
+ E TLN L+ + ++L D KK+F+ + + ++
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 910 NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 960
LE T+N+++ E + L +S+L + RK AE I + Y + + E
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 961 VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 997
E KA K+EL+ + +K + +VS E+ +R
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 998 FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1039
+ +E+K QL E + +E+ +++ ++N++ +++
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1593
Query: 1040 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1099
LQ+ L + +E + + +L LKDL + +E+ +++ K ++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 1100 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
+ Q L+ +++ E KSL + L+E+L + +R ++ +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 1153 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1201
+ L + + L + Q++E E+E G ++A +R+ ++++ E+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 1202 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1250
+ +S Q + A ++LE + E SK+K+T + LE +I+ L E++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 1251 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1306
R+ + A K + KD+K LL E+++ +Q KE+ +K + +L+R+
Sbjct: 1834 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 1307 IQES---AKQIEAKDNKITELLNDVERLKQAL 1335
++E+ +++I A K+ L++ +A+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 137 bits (344), Expect = 1e-31
Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)
Query: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 545
+E+++ ED L+ ++R ++E ++K+++ + +LTEE L++Q
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 895
Query: 546 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 604
L+ Y A AE ++R K+ E+ EE + E +L EE R Q+ + ER+K
Sbjct: 896 LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 947
Query: 605 KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 664
+++ ++E Q +E A +K + K + ++ + +++ M+ ++ K E
Sbjct: 948 MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 665 RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 724
+ L+ + ++ LA EE E+ K+ +T+L K++++ E+E
Sbjct: 1002 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1041
Query: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 784
+L KE+ +E +K+ + D + ++ D+ + E K+++ K
Sbjct: 1042 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 785 LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 837
+ + L ++RL+ K+I L+ +I +L++ L ++ +K+ +
Sbjct: 1088 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 838 QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 893
E++ AL +E L + Q + K +EV K L++ ++ ++++K
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 949
+E + ++ + K NL+ + ++ E LA + Q + +K++ E+
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 950 LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 1009
+ G+ L+ ++ + E++++ + E E K K++
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1314
Query: 1010 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1069
S+ + +EE ++ + KL++ L+++ +++ E ++ L R LN
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 1070 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1129
QL D +K + + E L E + EI + +++ +++E K L ++
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 1130 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1189
+L +L + ++ ++ K QLL +KN S A+ EA +E SL
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 1190 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
EE+ EE+ + ++ + L + ++ + + +K LETQ+ + +L
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1548
Query: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1309
EE+ +E+ + ++ + + L E++++ + E+ ++ +LQR++ E
Sbjct: 1549 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1600
Query: 1310 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1369
++E + + ++L+ L L ++ + + + LQ Q+K +++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 1370 LADADRQHQEVIA 1382
L DA E+ A
Sbjct: 1661 LEDARASRDEIFA 1673
Score = 121 bits (303), Expect = 5e-27
Identities = 189/943 (20%), Positives = 375/943 (39%), Gaps = 102/943 (10%)
Query: 249 LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 308
LT LK E+ E+ K ++ L ++ ++ + H+ I DL+ + +LK
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1083
Query: 309 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 361
+L K ++E + L +++ Q N + +LE +E L S AA+ EKQ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 362 SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 420
+EALK + +S +E +LK+ D + S +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1199
Query: 421 SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 465
+ +E L QT EN L EL + AKQ+ +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1255
Query: 466 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 525
+L +V E ++ + ER + + ++++ +L++ ++ V + E+EGK ++ +L
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 526 HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 569
L T E R L EE L+DQL + + + L Q+
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 570 NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 628
++ +++F L E KR QKE+ + E+K ++E L +L L +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 629 AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 687
+ + S+L + + + L E + K E + + E + K + EE
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 688 EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 747
+ K LE+ + L ++ +L + K + ++ + L+ Q + +++ L
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 748 KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 803
+ +ED K + A+ R L ++ EK+ ++++ L E ++ +D + +
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 804 VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 855
+K E + + E KQL +L+ + + Q ++ + +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 856 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 912
K+ E M L + LA R + E++ +E L KR LE
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 913 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 969
Q++ E L E + M ++S +RK ++ LA R ++ + +++
Sbjct: 1736 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 970 QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1025
Q KEL + ++ +K K+ ++ A E ++ QL EQ ++ + ++ K
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1842
Query: 1026 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNV 1085
+ ++ DK KEI + D+ + E+ E + + +L +QL++ ++ +
Sbjct: 1843 SLKQKDKKLKEILL---QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 1086 KEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1126
+ KL E A +++E + +V ALK L G
Sbjct: 1900 RRKLQRELDEATESNEAMG------------REVNALKSKLRG 1930
Score = 94.7 bits (234), Expect = 5e-19
Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)
Query: 984 KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1043
K P++ E + +A E EL+ + E+ QK +E E+K+ +Q++ +L +E LQ+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 895
Query: 1044 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1103
L+ +T L ++ EM L+ K EL + L ++ + E ++ ++L E K ++L +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1104 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1163
+ L+++ ++++ K + I+ L++E+ M + + ++K +LLE +
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1007
Query: 1164 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1223
L A E+E L+ K E +++E +L+ E + ++Q L+KL+ +
Sbjct: 1008 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1061
Query: 1224 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1283
D S + +DL+ QI+ L +LA K EE + L EI+ K+ +E
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 1284 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1329
I D +E D + +++ ++ +++EA ++ + L+ +V
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 1330 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1378
LK+AL+ ++ + + +Q ++ L Q++ ++ A+ D+ Q
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Score = 81.6 bits (200), Expect = 5e-15
Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)
Query: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1018
++ E++A++ EL +E + + E+ + + L++QL +T+ Y+
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 1019 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
+EE + KQE L++ L + +E+ + + L + ++ +Q+ DL
Sbjct: 906 AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1076 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1128
++ E + ++KL E K EIL + + K + +E L +
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 1129 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1176
+E+ K++ + K + +++L L+ ++ S L + H QI +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1074
Query: 1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1230
+ ++ +K L +KEEE Q +++L E+ ALKK+ E DL +
Sbjct: 1075 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1231 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1290
A ++ E Q L E+L L + E+ + A ++E+ AK E+E+ ++ ++ D++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1186
Query: 1291 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346
R ++ + E++++ ++E +Q+E L + + L++ L+ G
Sbjct: 1187 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1380
+ L+ QV+ L+ + +D +R E+
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 159 bits (403), Expect = 1e-38
Identities = 212/1033 (20%), Positives = 435/1033 (42%), Gaps = 148/1033 (14%)
Query: 442 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 501
LKK+++ ++ A++++ +N++ + E AL DE + +L K
Sbjct: 999 LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAAL-----------DESVARLTKEKKA 1047
Query: 502 VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QLKDLKVKYEG 555
+Q+ ++ G L +E S RL ++++D Q K L++ E
Sbjct: 1048 LQEAHQQALGD--------LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER 1099
Query: 556 ASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG-------RK 608
A KL +K + V + +D+ +L E+ K+ ELS + E + +K
Sbjct: 1100 AKR---KLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKK 1156
Query: 609 VTEMEGQAKELSAKLALSIPAE-KFENMKSSLSNEVNEKAKKLVEM------EREH-EKS 660
+ E++ +A+EL +L A + E ++ + E+ E +++L E +RE K
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR 1216
Query: 661 LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQK----SGELGKKITELTLKNQTLQ 716
+E+ +L+RELE + HE + L +K + ELG+++ L Q L+
Sbjct: 1217 EAELGRLRRELEEAALR---------HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE 1267
Query: 717 KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ--- 773
KE ++ ++ L LT + + ED +++L R+L D +
Sbjct: 1268 KEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRG 1327
Query: 774 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 833
+ + E+ +LL E + L +SR + + ++ EL++QL E K
Sbjct: 1328 RLQTESGELSRLLEEKECLISQLSRGKALAA-------------QSLEELRRQLEEESKA 1374
Query: 834 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE-D 892
+ AL + L++ + E + L L+K N E+ + K+E D
Sbjct: 1375 KSALAHAVQALRHDCDLLREQHEEE-------AEAQAELQRLLSKANAEVAQWRSKYEAD 1427
Query: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILAN 952
Q ++++ + L L+ + ++A AK SSL ++ ++Q + ++
Sbjct: 1428 AIQRTEELEEAKKKLALRLQEAEEGVEAA-------NAKCSSLEKAKLRLQTESEDVTLE 1480
Query: 953 YRKGQEEIVTL--------------HAEIKAQKKELDTIQ--------ECIKVKYAPIVS 990
+ L + + ++EL+ Q E ++++ +
Sbjct: 1481 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1540
Query: 991 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1050
E E K K L++++S+ T + S+S + +++ ++ L+ E +Q L +
Sbjct: 1541 LEALET-LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGA 1599
Query: 1051 IE----KSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1106
+E K+ ++ LS+ E++++L + ++ ++ ++ VE ++Q
Sbjct: 1600 LELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVE----------SLQAS 1649
Query: 1107 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQ--LLENQ--KNS 1162
L + + LKK + G + +L+ +L R E Q T+L Q L E Q ++
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDE 1708
Query: 1163 SVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETR 1221
LA L + +A E+ ++ A L E + + E+ + L L ++
Sbjct: 1709 EQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Query: 1222 EVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL-------HAKKKEISAKDE 1274
L++ K ++DL Q+S E+ A R+ EE ++ + KKE
Sbjct: 1769 NTGLLNQKKKLEADL-AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAH 1827
Query: 1275 KELLHFSIEQEIKDQKERCDKSLTT--------ITELQRRIQESAKQIEAKDNKITELLN 1326
E + ++EQ +++ + R +++ + +L+ +++E +++A+ K E L
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 1327 DVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR- 1385
V + ++ + L+ R L+D LQ +VKS ++Q +A++Q +A YR
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRK 1947
Query: 1386 -THLLSAAQGHMD 1397
H L A+ D
Sbjct: 1948 AQHELDDAEERAD 1960
Score = 135 bits (340), Expect = 3e-31
Identities = 220/1068 (20%), Positives = 455/1068 (42%), Gaps = 115/1068 (10%)
Query: 294 QNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 353
+ ++D E N DL R RK++ E L ++ L+L L + E++ + L +A
Sbjct: 973 ERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMA 1032
Query: 354 AKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGI 413
A +ES+ + K + LG A+ S
Sbjct: 1033 AL----DESVARLTKEKKALQEAHQQALGD------------------LQAEEDRVSALT 1070
Query: 414 PAHMQSRSMLRPLELSLPSQTSY-SENEILKKELEA-MRTFCES---AKQDRLKLQNELA 468
A ++ + LE SL + + E K++LE ++ ES A QD+ +L+ +L
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130
Query: 469 HKVAECKALALECERVKEDSDEQI--KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 526
K +E L+L E DEQ+ Q++ +K++Q R E E ++ + + A E
Sbjct: 1131 KKDSELSQLSLRVE------DEQLLGAQMQKKIKELQARAEELEEEL-EAERAARARVEK 1183
Query: 527 LTSEAASGNHRLTEELKDQLKDLKVKYEGA---SAEVGKLRNQIKQ----NEMIVEEFKR 579
+EAA L+E L++ + EG AE+G+LR ++++ +E V +R
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243
Query: 580 DE----GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFEN 634
+ +L E+ LQ+ E E+ + +V ++ + L+ AK + +E+
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303
Query: 635 MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 694
S +V E ++L + + + +E +L R LE + ++Q + K+
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQ------LSRGKALA 1357
Query: 695 EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL--KVSED 752
Q EL +++ E + L ++ + D LL+EQ H E + L K + +
Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQ-HEEEAEAQAELQRLLSKANAE 1416
Query: 753 M-----KKSHDAI-----IDDLNRKLLDVTQKYTE-------KKLEMEKLLLENDSLSKD 795
+ K DAI +++ +KL Q+ E K +EK L + S+D
Sbjct: 1417 VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476
Query: 796 VS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 854
V+ LE +K+ L+ + E ++Q E++++ Q + L +E L+
Sbjct: 1477 VTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHG 1536
Query: 855 MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 914
++T + L + ++ ++ K +++ + ++ + ++ LE
Sbjct: 1537 HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 915 QNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 973
+ ++ E + ++S + + RK+ + + E R Q + +L A + A+ +
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRA 1656
Query: 974 LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
+ E +++K +K + +L+ QL T++ + ++ + + + L
Sbjct: 1657 RN---EALRLK-----------KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ---L 1699
Query: 1034 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1093
K+E Q ++ L + HE +AL R+ L +L++L + E +L E+
Sbjct: 1700 KEE----QAGRDEEQRLAAELHEQAQALERRASLLAAELEEL-RAALEQGERSRRLAEQE 1754
Query: 1094 AKQTSEILAVQNLLQKQHVPL----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTV 1149
+ +E L NLL Q+ L +++EA L+G +E +E + + EK ++ +
Sbjct: 1755 LLEATERL---NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAE---EKAKKAI 1808
Query: 1150 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEV 1208
T + E K A ++K+ E+ V ++A L E E+ + + ++V KL+++V
Sbjct: 1809 TDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKV 1868
Query: 1209 QNTKQAL---KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
+ + L +K + + K++ +L Q + LA + +++ +V K
Sbjct: 1869 RELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYK 1928
Query: 1266 KKEISAKDEKE---LLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1310
++ A+ + + + E+ D +ER D + T +L+ R +++
Sbjct: 1929 RQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDA 1976
Score = 125 bits (314), Expect = 3e-28
Identities = 221/1023 (21%), Positives = 411/1023 (40%), Gaps = 198/1023 (19%)
Query: 423 LRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECE 482
++PL L S + E L+ EL +R +A+ R +L+ E LAL+ +
Sbjct: 885 MKPL---LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQ 941
Query: 483 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE- 541
+++ + E+ + K + EGKVK++ L +E + ++ A+ +L +E
Sbjct: 942 AEQDN----LADAEERCHLLIKSKVQLEGKVKELSER-LEDEEEVNADLAARRRKLEDEC 996
Query: 542 --LKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 599
LK + DLK+ A E N++K + +L +E K LQ E
Sbjct: 997 TELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ------E 1050
Query: 600 MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVN-----EKAKKLVEME 654
++ G E + + AKL L ++ E+++ SL E E+AK+ +E +
Sbjct: 1051 AHQQALGDLQAEEDRVSALTKAKLRLE---QQVEDLECSLEQEKKLRMDTERAKRKLEGD 1107
Query: 655 RE-HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS---GELGKKITELTL 710
+ ++S+++ Q K++LE K K E Q+ R+E + ++ KKI EL
Sbjct: 1108 LKLTQESVADAAQDKQQLEEKLKK-----KDSELSQLSLRVEDEQLLGAQMQKKIKELQA 1162
Query: 711 KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS-------------------- 750
+ + L++E+E +++Q E++ L+ +
Sbjct: 1163 RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGR 1222
Query: 751 -----EDMKKSHDAIIDDLNRKLLDVTQKYTEK---------KLEMEK--LLLENDSLSK 794
E+ H+A + L RK + + E+ KLE EK L +E D L+
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1282
Query: 795 DVSRLETVFVPPEK----HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTN 850
+V L EK +E ++ K + EL++QL++ + G L +E+
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGR-------LQTESGE 1335
Query: 851 LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRN 910
L +++ + + K +L + R+L + K + ++ ++L+
Sbjct: 1336 LSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE- 1394
Query: 911 LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ 970
+HE + + ++ R + +NAE+ A +R
Sbjct: 1395 ----------------QHEEEAEAQAELQRLLSKANAEV-AQWRS--------------- 1422
Query: 971 KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1030
K E D IQ EE E E K +L+ + Q+ +EE V+ +
Sbjct: 1423 KYEADAIQRT-----------EELE--------EAKKKLALRLQE---AEEGVEAANAKC 1460
Query: 1031 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLV 1090
L+K LQ + D T+ +E++ AL +K L + L++ ++ E++ E
Sbjct: 1461 SSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQ 1520
Query: 1091 EENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1150
E+ +E L + +H E +EAL E LK E K++Q
Sbjct: 1521 RESRGLGTE------LFRLRHGHEEALEAL--------ETLKRENKNLQE---------- 1556
Query: 1151 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQN 1210
++ L + S + E + K+A E E I+A+L E E E++
Sbjct: 1557 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL------------ELEE 1604
Query: 1211 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEIS 1270
TK +LE +V K++++ +++ +E+ ANL R ++ E + + E
Sbjct: 1605 TKTLRIQLELSQV---------KAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655
Query: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQ---RRIQESAKQIEAKDNKITELLND 1327
A++E L +E ++ D + + + TE Q R +Q K+ +A ++ L +
Sbjct: 1656 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715
Query: 1328 VERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVI-AIYRT 1386
+ QAL +R S L L+ +LEQ QE++ A R
Sbjct: 1716 LHEQAQALE-------------RRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Query: 1387 HLL 1389
+LL
Sbjct: 1763 NLL 1765
Score = 70.1 bits (170), Expect = 1e-11
Identities = 87/441 (19%), Positives = 186/441 (42%), Gaps = 30/441 (6%)
Query: 252 LKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNV--KSHQREHQNIQDLEIENEDLKER 309
L+ E + E K+ Q ++ + D+V++ KS Q + + LE E +++
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592
Query: 310 LRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 369
L + + + K +QL+L++ D +E+++ A + H+ ++ +++A
Sbjct: 1593 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAVESLQAS 1649
Query: 370 KNRFKYFESDHLGSGSHFSNRKEDMLLKQGQ--MYMADSQCTSPGIPAHMQSRSMLR--- 424
+ ++ L D+ L+ G ++Q + + A ++ R
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 425 ---PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 481
EL +Q +L ELE +R E ++ R + EL L +
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769
Query: 482 ERV---KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNH-- 536
+ K+ + + QL +++ + E+E K K+ T + E L E + H
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1829
Query: 537 RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELS 596
R+ + L+ +++L+ + E AE LR KQ + + + + E +L E K+ + L
Sbjct: 1830 RMKKTLEQTVRELQARLE--EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 597 MCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMERE 656
K R+V E+ QA+E LA + +++ L ++V ++ E E++
Sbjct: 1888 GV----RKHERRVKELAYQAEEDRKNLA------RMQDLVDKLQSKVKSYKRQFEEAEQQ 1937
Query: 657 HEKSLSEIRQLKRELENVKAK 677
+L++ R+ + EL++ + +
Sbjct: 1938 ANTNLAKYRKAQHELDDAEER 1958
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 157 bits (398), Expect = 5e-38
Identities = 218/999 (21%), Positives = 422/999 (42%), Gaps = 122/999 (12%)
Query: 487 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH-----LTSEAASGNHRLTEE 541
++++++ +++ +++ + +SE + K+++ ++L + L +A N EE
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 542 LKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK-----ELS 596
DQL K++ E A+V ++ +++ E + E + KL +E L+K EL+
Sbjct: 906 RCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 597 MCEMEREK-----KGRKVTEMEGQAKELSAKLALSIPA--EKFENMKSSLSNE---VNEK 646
+ ++E+EK K + +TE E+ AKL A E + L E VN
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSL 1022
Query: 647 AKKLVEMEREH---EKSLSEIRQLKRELENVKAKLAQHVKPEEH-----EQVKSRLEQKS 698
+K V++E++ E SL + ++++ +LE K KL +K + E K +LE+K
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK- 1081
Query: 699 GELGKKITELTLKNQTLQKE-IEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSH 757
L KK ++ +N ++ E + + L KL + QA +E + L+ +
Sbjct: 1082 --LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE-----LEAERTARAKV 1134
Query: 758 DAIIDDLNRKLLDVTQKYTE------------KKLEMEKLLLENDSLSKDVSRLETVFVP 805
+ + DL+R+L +++++ E KK E E + D + T
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 806 PEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTH 865
+KH + L I L++ +L+K+ E + ++ +TS + K +N
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL------- 1247
Query: 866 EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 925
E+V TL D + +L + ++ D + K++ +N L R LE + I
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK 1307
Query: 926 AEHEAKMSSLSQSMR---KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 982
+ +M L + + K +++ A L + R + + + E K EL +
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 983 VKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQK 1042
+ A + E + + TE EL++ + Q+ +EE V+ + L+K LQ
Sbjct: 1368 SEVAQWRTKYETDA-IQRTE-ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425
Query: 1043 DLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1102
++ D V +E+S+ AL +K +K L + QKY E ++ E +E ++E+
Sbjct: 1426 EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1485
Query: 1103 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL-KSMQRCYE----KEQQTVTKLHQLLE 1157
++N ++ LE + K+L I +L E+L + + +E ++Q V KL L+
Sbjct: 1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE--LQ 1543
Query: 1158 NQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1216
+ + EH + K + E IKA + K E +ME+ + V ++ Q
Sbjct: 1544 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSL 1603
Query: 1217 KLETR---EVVDL-SKYKATKSDLETQISSLNEKLANLNRKYE----------------- 1255
ETR EV+ + K + +++E Q+S N A ++ +
Sbjct: 1604 DAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1663
Query: 1256 -------------EVCEEVLHAKKKEISA-KDEKELLHFSIEQEIKDQKERCD------- 1294
E +L A+ +E+ A ++ E EQE+ + ER
Sbjct: 1664 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1723
Query: 1295 -------KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGN 1347
K + +T+LQ ++E+ ++ + K + + D + + L +
Sbjct: 1724 SLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1783
Query: 1348 PTKRQSQLIDTLQHQVKSLEQ-QLADADRQHQEVIAIYR 1385
K Q I LQH++ EQ L +Q Q++ A R
Sbjct: 1784 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1822
Score = 149 bits (377), Expect = 1e-35
Identities = 227/1088 (20%), Positives = 470/1088 (43%), Gaps = 167/1088 (15%)
Query: 244 DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 299
D+L+ LTL K E NK + L ++ L + +++ K+ Q HQ + DL
Sbjct: 957 DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK---KALQEAHQQALDDL 1012
Query: 300 EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 359
++E ++++ + + + L +V+ L+ L +E V DLE + KL+ L K
Sbjct: 1013 QVE----EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL----KLT 1064
Query: 360 EESLRTIE----ALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPA 415
+ES+ +E L+ + K E D S + E +L Q Q + ++Q +
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIED--EQVLALQLQKKLKENQARIEELEE 1122
Query: 416 HMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL------KLQNELAH 469
+++ R L S S EI ++ EA + ++ K++ +L
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 470 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 529
+ +A A + DS ++ + D L+ V++++ + + + K + E +
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII- 1241
Query: 530 EAASGNHRLTEELKDQLKDLKVKYEGAS--------------AEVGKLRNQIKQNEMIVE 575
+A + +++ L+DQ + +VK E A E G+L Q+++ E ++
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS 1301
Query: 576 EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 635
+ R + ++ + L+++L E EG+AK A AL + +
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQL---------------EEEGKAKNALAH-ALQSARHDCDLL 1345
Query: 636 KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 695
+ E KA E++R K+ SE+ Q + + E + + EE E+ K +L
Sbjct: 1346 REQYEEETEAKA----ELQRVLSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLA 1396
Query: 696 QKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK 755
Q+ + + + + K +L+K + L+ + +L ++++ + ++
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHR-------LQNEIEDLMVDVERSNAAAAALDKKQR 1449
Query: 756 SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA 815
+ D I L + QKY E + E+E E SLS ++ +L+ + E+ + +
Sbjct: 1450 NFDKI-------LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY---EESLEHLET 1499
Query: 816 LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDT 875
K L++++S+L ++ GE + +H L L E K+ L
Sbjct: 1500 FKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL--------------EVEKLELQSA 1545
Query: 876 LAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI-SLAEHEAKMSS 934
L + L ++ +IL+ LE NQIKAE LAE + +M
Sbjct: 1546 LEEAEASLEH----------------EEGKILRAQLEF--NQIKAEIERKLAEKDEEMEQ 1587
Query: 935 LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC 994
++ ++V DS L + + E++ + +++ E++ I++ +A ++ E
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME-----IQLSHANRMA-AEA 1641
Query: 995 ERKFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD----- 1046
+++ K+ + LKD QL + + +E + ++ N+ L+ E+ L+ +
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701
Query: 1047 ---KTVLIEKSHEMERALSRKTDELNKQLK---DLSQKYTEVKNVKEKL--VEENAKQT- 1097
+ LIE S ++ S+ T +N++ K DL+Q +EV+ ++ EE AK+
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761
Query: 1098 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL--------KSMQRCYEKEQQTV 1149
++ + L+K+ +E +KK++ TI++L+ L K ++ +K + V
Sbjct: 1762 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1821
Query: 1150 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQS 1206
+L LE ++ + + ++ E KE+ + EE+ +N + + V KLQ
Sbjct: 1822 RELEGELEAEQKRNAESVKGMRKSERRIKELTY------QTEEDKKNLLRLQDLVDKLQL 1875
Query: 1207 EVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1266
+V+ K+ ++ E + +LSK++ + +L+ + + +N+ L AK
Sbjct: 1876 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK---------LRAKS 1926
Query: 1267 KEISAKDE 1274
++I AK +
Sbjct: 1927 RDIGAKQK 1934
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,708,721
Number of Sequences: 37866
Number of extensions: 2097106
Number of successful extensions: 37212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 871
Number of HSP's successfully gapped in prelim test: 1482
Number of HSP's that attempted gapping in prelim test: 10797
Number of HSP's gapped (non-prelim): 12075
length of query: 1416
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1301
effective length of database: 13,892,928
effective search space: 18074699328
effective search space used: 18074699328
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.