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Search of human proteins with 5921992
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5921992 adenosine A2a receptor [Homo sapiens]
(412 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5921992 adenosine A2a receptor [Homo sapiens] 838 0.0
gi|4501951 adenosine A2b receptor [Homo sapiens] 381 e-106
gi|115305569 adenosine A1 receptor [Homo sapiens] 301 9e-82
gi|4501947 adenosine A1 receptor [Homo sapiens] 301 9e-82
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 244 8e-65
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 140 2e-33
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 138 8e-33
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 138 1e-32
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 138 1e-32
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 138 1e-32
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 138 1e-32
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 138 1e-32
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 138 1e-32
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 137 2e-32
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 136 3e-32
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 135 9e-32
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 135 9e-32
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 134 2e-31
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 134 2e-31
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 133 3e-31
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 130 2e-30
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 126 3e-29
gi|4503383 dopamine receptor D1 [Homo sapiens] 125 7e-29
gi|28173558 trace amine associated receptor 6 [Homo sapiens] 116 4e-26
gi|110618256 trace amine associated receptor 9 [Homo sapiens] 115 9e-26
gi|5174535 melanocortin 5 receptor [Homo sapiens] 113 4e-25
gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens] 113 4e-25
gi|222080109 orexin receptor 2 [Homo sapiens] 111 1e-24
gi|222080095 orexin receptor 1 [Homo sapiens] 110 2e-24
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 105 1e-22
>gi|5921992 adenosine A2a receptor [Homo sapiens]
Length = 412
Score = 838 bits (2164), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
Sbjct: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI 60
Query: 61 PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
Sbjct: 61 PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR 120
Query: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
Sbjct: 121 AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 180
Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
Sbjct: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240
Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
Sbjct: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
Query: 301 KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG 360
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
Sbjct: 301 KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG 360
Query: 361 YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 412
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
Sbjct: 361 YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 412
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 381 bits (978), Expect = e-106
Identities = 196/330 (59%), Positives = 245/330 (74%), Gaps = 16/330 (4%)
Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66
++Y+ +EL IA L++ GNVLVC AV + LQ TNYF+VSLAAAD+AVG+ AIPFAITI
Sbjct: 8 ALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITI 67
Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
S GFC +GCLF+ACFVLVLTQSSIFSLLA+A+DRY+AI +PLRY LVTGTRA+G+IA
Sbjct: 68 SLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIA 127
Query: 127 ICWVLSFAIGLTPMLGW-------NNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVY 179
+ WVL+F IGLTP LGW NNC +P +G + C V CLFE+VVPM+YMVY
Sbjct: 128 VLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCC---LVKCLFENVVPMSYMVY 184
Query: 180 FNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIV 239
FNFF CVL PLL+ML +Y++IFL A RQL++ E + +R+TLQ+E+HAAKSLA+IV
Sbjct: 185 FNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELM----DHSRTTLQREIHAAKSLAMIV 240
Query: 240 GLFALCWLPLHIINCFTFFCP-DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQT 298
G+FALCWLP+H +NC T F P + P W M +AI+LSH NSVVNP +YAYR R+FR T
Sbjct: 241 GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT 300
Query: 299 FRKIIRSHVLRQQEPFKAAGTSARVLAAHG 328
F KII ++L Q + K+ A V A G
Sbjct: 301 FHKIISRYLLCQAD-VKSGNGQAGVQPALG 329
>gi|115305569 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 301 bits (770), Expect = 9e-82
Identities = 158/307 (51%), Positives = 202/307 (65%), Gaps = 3/307 (0%)
Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66
+ YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI I
Sbjct: 10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI 69
Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
+ G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA IA
Sbjct: 70 NIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIA 129
Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF V
Sbjct: 130 GCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWV 189
Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246
L PLLLM+ +YL +F R+QL + S + KE+ AKSLA+I+ LFAL W
Sbjct: 190 LPPLLLMVLIYLEVFYLIRKQLNKKVS--ASSGDPQKYYGKELKIAKSLALILFLFALSW 247
Query: 247 LPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306
LPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI H
Sbjct: 248 LPLHILNCITLFCPSC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDH 306
Query: 307 VLRQQEP 313
Q P
Sbjct: 307 FRCQPAP 313
>gi|4501947 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 301 bits (770), Expect = 9e-82
Identities = 158/307 (51%), Positives = 202/307 (65%), Gaps = 3/307 (0%)
Query: 7 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66
+ YI +E+ IA++++ GNVLV WAV +N L++ T F+VSLA AD+AVG L IP AI I
Sbjct: 10 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILI 69
Query: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
+ G H CL +AC VL+LTQSSI +LLAIA+DRY+ ++IPLRY +VT RA IA
Sbjct: 70 NIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIA 129
Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
CW+LSF +GLTPM GWNN + + GE + C FE V+ M YMVYFNFF V
Sbjct: 130 GCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWV 189
Query: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246
L PLLLM+ +YL +F R+QL + S + KE+ AKSLA+I+ LFAL W
Sbjct: 190 LPPLLLMVLIYLEVFYLIRKQLNKKVS--ASSGDPQKYYGKELKIAKSLALILFLFALSW 247
Query: 247 LPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH 306
LPLHI+NC T FCP C H P L Y+AI L+H NS +NP +YA+RI++FR TF KI H
Sbjct: 248 LPLHILNCITLFCPSC-HKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDH 306
Query: 307 VLRQQEP 313
Q P
Sbjct: 307 FRCQPAP 313
>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
Length = 318
Score = 244 bits (624), Expect = 8e-65
Identities = 127/305 (41%), Positives = 192/305 (62%), Gaps = 12/305 (3%)
Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63
+ + YIT+E+ I + AI+GNVLV V LN +LQ T YF+VSLA ADIAVGVL +P A
Sbjct: 10 LANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLA 69
Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123
I +S G + CLF+ C +L+ T +SI SLLAIA+DRY+ +++ +RY + T R
Sbjct: 70 IVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWL 129
Query: 124 IIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFF 183
+ +CW++SF +GLTPM GWN + +N + ++C F V+ M+YMVYF+F
Sbjct: 130 ALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVT------FLSCQFVSVMRMDYMVYFSFL 183
Query: 184 ACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFA 243
+ +PL++M +YL IF R +L S + + +E AKSL +++ LFA
Sbjct: 184 TWIFIPLVVMCAIYLDIFYIIRNKLSLNLSN---SKETGAFYGREFKTAKSLFLVLFLFA 240
Query: 244 LCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303
L WLPL IINC +F P ++Y+ I+LSH NS++NP +YAY+I++F++T+ I+
Sbjct: 241 LSWLPLSIINCIIYF---NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLIL 297
Query: 304 RSHVL 308
++ V+
Sbjct: 298 KACVV 302
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 140 bits (353), Expect = 2e-33
Identities = 129/375 (34%), Positives = 183/375 (48%), Gaps = 54/375 (14%)
Query: 14 LAIAVLAILG-NVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS-TG-F 70
LA+AVLA +G N+LV A+ LQ +TN FV SLAAAD+ +G+L +P A T++ TG +
Sbjct: 44 LALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHW 103
Query: 71 CAACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 129
GC L+ + VL +T +SI +L A+A+DRY+A+ PLRY LVT A+ + + W
Sbjct: 104 PLGATGCELWTSVDVLCVT-ASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVW 162
Query: 130 VLSFAIGLTPMLG-WNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188
V+S A+ P++ W G E +Q C C F +P V + +
Sbjct: 163 VVSAAVSFAPIMSQWWRVGADAE----AQRCHSNPRCCAFASNMP---YVLLSSSVSFYL 215
Query: 189 PLLLMLGVYLRIFLAARRQLKQM----------ESQPLP--------------------- 217
PLL+ML VY R+F+ A RQL+ + ES P P
Sbjct: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
Query: 218 GER-ARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF-TFFCPDCSHAPLWLMYLAIV 275
G R AR +E A +L +I+G F LCWLP + N P P +L
Sbjct: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL--ALNW 333
Query: 276 LSHTNSVVNPFIYAYRIREFRQTFRKII-RSHVLRQQEPFKAAGTS---ARVLAAHGSDG 331
L + NS NP IY R +FR FR+++ R EP AA + + V AA S
Sbjct: 334 LGYANSAFNPLIYC-RSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPA 392
Query: 332 E-QVSLRLNGHPPGV 345
+ ++ RL+G GV
Sbjct: 393 QPRLCQRLDGASWGV 407
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 138 bits (348), Expect = 8e-33
Identities = 107/336 (31%), Positives = 164/336 (48%), Gaps = 35/336 (10%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGE--------------GQVACLF 168
++ CWV+ I P++ GWNN G ++ +QG G+ C+F
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVF 200
Query: 169 EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPG 218
+V Y + + A +P LLM+ Y RI++ A+ Q+ ES+P
Sbjct: 201 --MVNKPYAITCSVVA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSA 257
Query: 219 ER-ARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLS 277
++ + ++ E AAK+L II+G F LCW P + N F +W +L L
Sbjct: 258 DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLG 315
Query: 278 HTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEP 313
+ NS +NPF+YA+ + FR+ F I+ R + P
Sbjct: 316 YINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 351
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 138 bits (347), Expect = 1e-32
Identities = 104/322 (32%), Positives = 158/322 (49%), Gaps = 21/322 (6%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNV-TNYFVVSLAAADIAVGVLAIPFAIT- 65
V +T + ++AILGN+LV AV + L+ + TNYF+VSLA AD+ V VL +PF
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 66 -ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRI-PLRYNGLVTGTRAKG 123
+ + CL ++LT +SIF L I++DRY AI PL Y +T R
Sbjct: 81 LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL 140
Query: 124 IIAICWVLSFAIGLTPML-GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
++ CWV+ I P++ GWNN G + C+F +V Y + +
Sbjct: 141 MLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVF--MVNKPYAITCSV 198
Query: 183 FACVLVPLLLMLGVYLRIFLAARRQLKQM----------ESQPLPGER-ARSTLQKEVHA 231
A +P LLM+ Y RI++ A+ Q+ ES+P ++ + ++ E A
Sbjct: 199 VA-FYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKA 257
Query: 232 AKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 291
AK+L II+G F LCW P + N F +W +L L + NS +NPF+YA+
Sbjct: 258 AKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFL--WLGYINSGLNPFLYAFL 315
Query: 292 IREFRQTFRKIIRSHVLRQQEP 313
+ FR+ F I+ R + P
Sbjct: 316 NKSFRRAFLIILCCDDERYRRP 337
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 137 bits (344), Expect = 2e-32
Identities = 96/337 (28%), Positives = 160/337 (47%), Gaps = 56/337 (16%)
Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST-GFCAA 73
A ++A+ GN+LV +V N +LQ VTNYF+V+LA AD+ + +PF+ T+ GF A
Sbjct: 105 AFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAF 164
Query: 74 CHG-CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132
C A ++ +SI SL I++DRY+ +R L+Y ++T +A I+A+ WV++
Sbjct: 165 GRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVA 224
Query: 133 FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192
+ + P+LGW P E + CG + A Y V F+ +P+ +
Sbjct: 225 LVVSVGPLLGWKEPVPPDE-----RFCGITEEA---------GYAV-FSSVCSFYLPMAV 269
Query: 193 MLGVYLRIFLAARRQLKQMES-------------------------------QPLPGERA 221
++ +Y R+++ AR + +E+ + G
Sbjct: 270 IVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTF 329
Query: 222 RSTL-------QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAI 274
RS+L +E AAK+LAI+VG+F LCW P + P + + +
Sbjct: 330 RSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSE-GVFKVIF 388
Query: 275 VLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ 311
L + NS VNP IY REF++ F +++R R++
Sbjct: 389 WLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRR 425
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 136 bits (343), Expect = 3e-32
Identities = 119/391 (30%), Positives = 176/391 (45%), Gaps = 75/391 (19%)
Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTG----- 69
I +L I GN LV +V L+ +NY +VSLA AD++V V +PF ++T G
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 70 ---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
FC +FIA V+ T +SI +L I+IDRY+ I PL Y G +I
Sbjct: 151 GHFFCN-----VFIAMDVMCCT-ASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMIL 204
Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
W+LS +I L P+ GW +Q + +V + +D Y +Y A
Sbjct: 205 SVWLLSASITLPPLFGW------------AQNVNDDKVCLISQD---FGYTIYSTAVA-F 248
Query: 187 LVPLLLMLGVYLRIFLAARRQL--------------------------KQME-----SQP 215
+P+ +ML +Y +I+ AAR+ K++E S+
Sbjct: 249 YIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRL 308
Query: 216 LPGERAR-STLQKEVHAAKSLAIIVGLFALCWLPLHIIN-CFTFFC-PDCSHAPLWLMYL 272
L ER S ++E AA +L IIVG F +CWLP +++ F C CS PLW+
Sbjct: 309 LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERT 368
Query: 273 AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSD-- 330
+ L + NS++NPFIYA+ R+ R T+R +++ AAG + A +
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERP 428
Query: 331 -------GEQVSLRLNGHPP-GVWANGSAPH 353
+V LR PP VW S H
Sbjct: 429 EFVLRACTRRVLLRPEKRPPVSVWVLQSPDH 459
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 135 bits (339), Expect = 9e-32
Identities = 109/346 (31%), Positives = 163/346 (47%), Gaps = 65/346 (18%)
Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTG----- 69
I +L I GN LV +V L+ +NY +VSLA AD++V V +PF ++T G
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 70 ---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
FC +FIA V+ T +SI +L I+IDRY+ I PL Y G +I
Sbjct: 151 GHFFCN-----VFIAMDVMCCT-ASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMIL 204
Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
W+LS +I L P+ GW +Q + +V + +D Y +Y A
Sbjct: 205 SVWLLSASITLPPLFGW------------AQNVNDDKVCLISQD---FGYTIYSTAVA-F 248
Query: 187 LVPLLLMLGVYLRIFLAARRQL--------------------------KQME-----SQP 215
+P+ +ML +Y +I+ AAR+ K++E S+
Sbjct: 249 YIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRL 308
Query: 216 LPGERAR-STLQKEVHAAKSLAIIVGLFALCWLPLHIIN-CFTFFC-PDCSHAPLWLMYL 272
L ER S ++E AA +L IIVG F +CWLP +++ F C CS PLW+
Sbjct: 309 LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERT 368
Query: 273 AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAG 318
+ L + NS++NPFIYA+ R+ R T+R +++ AAG
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 135 bits (339), Expect = 9e-32
Identities = 109/346 (31%), Positives = 163/346 (47%), Gaps = 65/346 (18%)
Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTG----- 69
I +L I GN LV +V L+ +NY +VSLA AD++V V +PF ++T G
Sbjct: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150
Query: 70 ---FCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
FC +FIA V+ T +SI +L I+IDRY+ I PL Y G +I
Sbjct: 151 GHFFCN-----VFIAMDVMCCT-ASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMIL 204
Query: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
W+LS +I L P+ GW +Q + +V + +D Y +Y A
Sbjct: 205 SVWLLSASITLPPLFGW------------AQNVNDDKVCLISQD---FGYTIYSTAVA-F 248
Query: 187 LVPLLLMLGVYLRIFLAARRQL--------------------------KQME-----SQP 215
+P+ +ML +Y +I+ AAR+ K++E S+
Sbjct: 249 YIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRL 308
Query: 216 LPGERAR-STLQKEVHAAKSLAIIVGLFALCWLPLHIIN-CFTFFC-PDCSHAPLWLMYL 272
L ER S ++E AA +L IIVG F +CWLP +++ F C CS PLW+
Sbjct: 309 LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERT 368
Query: 273 AIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAG 318
+ L + NS++NPFIYA+ R+ R T+R +++ AAG
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 134 bits (336), Expect = 2e-31
Identities = 95/302 (31%), Positives = 154/302 (50%), Gaps = 25/302 (8%)
Query: 8 VYITVELAIAVL-AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66
+ ITV LA+ +L + GNV+VC AV LN L+N+TN F+VSLA D+ +G+L +PF+
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 67 STGFCAACHGCLFIACFV---LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123
C G +F + ++L +SI +L I++DRY A+ PLRY LVT R
Sbjct: 79 QLS-CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 124 IIAICWVLSFAIG-LTPMLGWNNCGQPKEGKNHSQGC--GEGQVACLFEDVVPMNYMVYF 180
+ + WV+S + L+ LGWN+ + +G + + C +V L + +V
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTF------ 191
Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240
+PLL+M Y RIF AR Q K++ ++ +E A +LA ++G
Sbjct: 192 ------YLPLLIMCITYYRIFKVARDQAKRINHI----SSWKAATIREHKATVTLAAVMG 241
Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
F +CW P + D + + L + + L + NS +NP +YA R+FR ++
Sbjct: 242 AFIICWFPYFTAFVYRGLRGDDAINEV-LEAIVLWLGYANSALNPILYAALNRDFRTGYQ 300
Query: 301 KI 302
++
Sbjct: 301 QL 302
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 134 bits (336), Expect = 2e-31
Identities = 95/302 (31%), Positives = 154/302 (50%), Gaps = 25/302 (8%)
Query: 8 VYITVELAIAVL-AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI 66
+ ITV LA+ +L + GNV+VC AV LN L+N+TN F+VSLA D+ +G+L +PF+
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 67 STGFCAACHGCLFIACFV---LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKG 123
C G +F + ++L +SI +L I++DRY A+ PLRY LVT R
Sbjct: 79 QLS-CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 124 IIAICWVLSFAIG-LTPMLGWNNCGQPKEGKNHSQGC--GEGQVACLFEDVVPMNYMVYF 180
+ + WV+S + L+ LGWN+ + +G + + C +V L + +V
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTF------ 191
Query: 181 NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 240
+PLL+M Y RIF AR Q K++ ++ +E A +LA ++G
Sbjct: 192 ------YLPLLIMCITYYRIFKVARDQAKRINHI----SSWKAATIREHKATVTLAAVMG 241
Query: 241 LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
F +CW P + D + + L + + L + NS +NP +YA R+FR ++
Sbjct: 242 AFIICWFPYFTAFVYRGLRGDDAINEV-LEAIVLWLGYANSALNPILYAALNRDFRTGYQ 300
Query: 301 KI 302
++
Sbjct: 301 QL 302
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 133 bits (334), Expect = 3e-31
Identities = 130/464 (28%), Positives = 193/464 (41%), Gaps = 92/464 (19%)
Query: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST-GFCAA 73
A + AI+GN+LV +V N +L+ TNYF+V+LA AD+ + +PF+ + G+
Sbjct: 54 AFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVL 113
Query: 74 CH-GCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC--WV 130
C A ++ +SI SL AI+IDRYI +R L+Y LVT R K I+A+ WV
Sbjct: 114 GRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVT--RRKAILALLSVWV 171
Query: 131 LSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPL 190
LS I + P+LGW + N + CG V + F+ +PL
Sbjct: 172 LSTVISIGPLLGWK-----EPAPNDDKECG----------VTEEPFYALFSSLGSFYIPL 216
Query: 191 LLMLGVYLRIFLAARRQLKQME----------------------------SQPLPGERAR 222
++L +Y R+++ A+R K +E S G R
Sbjct: 217 AVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR 276
Query: 223 STL-------QKEVHAAKSLAIIVGLFALCWLPLHII----NCFTFFCPDCSHAPLWLMY 271
S++ +E AAK+L I+VG+F LCWLP I + F+ P P +
Sbjct: 277 SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP-----PDAVFK 331
Query: 272 LAIVLSHTNSVVNPFIYAYRIREFRQTFRKII----RSHVLRQQ-------------EPF 314
+ L + NS +NP IY +EF++ F +I+ R R++ P+
Sbjct: 332 VVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPW 391
Query: 315 KAAGTSARVLAAHGS--------DGEQVSLRLNGHPPGVWANGSAPHPE--RRPNGYALG 364
G+ R + S G Q +L PG G+ P E P A G
Sbjct: 392 TRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPG 451
Query: 365 LVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDG 408
+ A E G G D L PE PG D + G
Sbjct: 452 ALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGG 495
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 130 bits (327), Expect = 2e-30
Identities = 111/369 (30%), Positives = 166/369 (44%), Gaps = 81/369 (21%)
Query: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI--------S 67
I +L + GNVLV A+ LQ +TN F++SLA+AD+ +G+L +PF TI
Sbjct: 68 IVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYG 127
Query: 68 TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAI 127
+ FC L+ + VL +T +SI +L IA+DRY+AI P RY L+T RA+G++
Sbjct: 128 SFFCE-----LWTSVDVLCVT-ASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCT 181
Query: 128 CWVLSFAIGLTPML--GWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC 185
W +S + P+L W + + ++ C C D V +
Sbjct: 182 VWAISALVSFLPILMHWW------RAESDEARRCYNDPKCC---DFVTNRAYAIASSVVS 232
Query: 186 VLVPLLLMLGVYLRIFLAARRQLKQMES-----------------QPLP----------- 217
VPL +M VYLR+F A++Q+K+++S P+P
Sbjct: 233 FYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRP 292
Query: 218 --------------GERARSTL--QKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPD 261
G+R S L +E A K+L II+G+F LCWLP + N F +
Sbjct: 293 AAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE 352
Query: 262 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII--------RSHVLRQQEP 313
P L L + NS NP IY R +FR+ F+ ++ R H P
Sbjct: 353 L--VPDRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHGDRP 409
Query: 314 FKAAGTSAR 322
+A+G AR
Sbjct: 410 -RASGCLAR 417
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 126 bits (317), Expect = 3e-29
Identities = 102/344 (29%), Positives = 162/344 (47%), Gaps = 40/344 (11%)
Query: 12 VELAIAVLAIL-GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITIST 68
+ +++ VLAI+ GNVLV A+ LQ VTNYF+ SLA AD+ +G+ +PF A +
Sbjct: 38 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97
Query: 69 GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAIC 128
+ C F ++ +SI +L IA+DRY AI P +Y L+T +A+ II +
Sbjct: 98 MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 157
Query: 129 WVLSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL 187
W++S P+ + W + + C + C D +
Sbjct: 158 WIVSGLTSFLPIQMHWY-----RATHQEAINCYANETCC---DFFTNQAYAIASSIVSFY 209
Query: 188 VPLLLMLGVYLRIFLAARRQLK---------------QMESQPLPGERARSTLQ---KEV 229
VPL++M+ VY R+F A+RQL+ Q+E G R + + KE
Sbjct: 210 VPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEH 269
Query: 230 HAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYA 289
A K+L II+G F LCWLP I+N + +++ L + + NS NP IY
Sbjct: 270 KALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYI--LLNWIGYVNSGFNPLIYC 327
Query: 290 YRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQ 333
R +FR F++++ ++ KA G +++G+ GEQ
Sbjct: 328 -RSPDFRIAFQELL----CLRRSSLKAYGNG---YSSNGNTGEQ 363
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 125 bits (314), Expect = 7e-29
Identities = 89/320 (27%), Positives = 156/320 (48%), Gaps = 34/320 (10%)
Query: 14 LAIAVLA-ILGNVLVCWAVWLNSNLQN-VTNYFVVSLAAADIAVGVLAIPF-AITISTGF 70
L++ +L+ +LGN LVC AV +L++ VTN+FV+SLA +D+ V VL +P+ A+ GF
Sbjct: 30 LSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGF 89
Query: 71 CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV 130
C F ++ + +SI +L I++DRY AI P RY +T A +I++ W
Sbjct: 90 WPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWT 149
Query: 131 LSFAIGLTPM-LGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVP 189
LS I P+ L W+ ++ E C + + Y + + + +P
Sbjct: 150 LSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNC--DSSLSRTYAISSSVIS-FYIP 206
Query: 190 LLLMLGVYLRIFLAARRQLKQM------------------ESQPL----PGERARSTLQK 227
+ +M+ Y RI+ A++Q++++ +P+ P + + ++
Sbjct: 207 VAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKR 266
Query: 228 EVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWL----MYLAIVLSHTNSVV 283
E K+L++I+G+F CWLP I+NC FC P + + + NS +
Sbjct: 267 ETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSL 326
Query: 284 NPFIYAYRIREFRQTFRKII 303
NP IYA+ +FR+ F ++
Sbjct: 327 NPIIYAFN-ADFRKAFSTLL 345
>gi|28173558 trace amine associated receptor 6 [Homo sapiens]
Length = 345
Score = 116 bits (290), Expect = 4e-26
Identities = 98/322 (30%), Positives = 156/322 (48%), Gaps = 36/322 (11%)
Query: 5 GSSVYITVELAI-AVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63
GS V + + AVLA+ GN+LV ++ L + TN+ V SLA AD VGV +PF+
Sbjct: 30 GSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFS 89
Query: 64 I--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRA 121
+ T+ + + C F C + SS+F L I+IDRYIA+ PL Y T + +
Sbjct: 90 MVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTKFTVSVS 149
Query: 122 KGIIAICWVL----SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYM 177
I++ W+L S A+ T + + + + N GC + VV N++
Sbjct: 150 GICISVSWILPLMYSGAVFYTGVYD-DGLEELSDALNCIGGC---------QTVVNQNWV 199
Query: 178 V--YFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARST-----LQKEVH 230
+ + +FF +P +M+ +Y IFL ARRQ K++E+ E + + ++E
Sbjct: 200 LTDFLSFF----IPTFIMIILYGNIFLVARRQAKKIENTGSKTESSSESYKARVARRERK 255
Query: 231 AAKSLAIIVGLFALCWLPLHI---INCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFI 287
AAK+L + V F + WLP I I+ F F P + + ++ NS +NP I
Sbjct: 256 AAKTLGVTVVAFMISWLPYSIDSLIDAFMGFI-----TPACIYEICCWCAYYNSAMNPLI 310
Query: 288 YAYRIREFRQTFRKIIRSHVLR 309
YA FR+ + I+ VL+
Sbjct: 311 YALFYPWFRKAIKVIVTGQVLK 332
>gi|110618256 trace amine associated receptor 9 [Homo sapiens]
Length = 348
Score = 115 bits (287), Expect = 9e-26
Identities = 91/306 (29%), Positives = 145/306 (47%), Gaps = 29/306 (9%)
Query: 17 AVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFC--AAC 74
AVLA GN+LV A+ L TN+ + SLA AD VGV +PF+ S C
Sbjct: 43 AVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGD 102
Query: 75 HGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA 134
C F CF +S+F L I++DRYIA+ PL Y T + IC VLS+
Sbjct: 103 SYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFT----VSVSGICIVLSWF 158
Query: 135 IGLTPMLGWNNCGQPKEGKNH---SQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLL 191
+T G +EG + C G A L ++ V + ++++F +P +
Sbjct: 159 FSVTYSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLLFF-------IPNV 211
Query: 192 LMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEV-----HAAKSLAIIVGLFALCW 246
M+ +Y +IFL A+ Q +++ES + + + ++ V AAK+L I + F + W
Sbjct: 212 AMVFIYSKIFLVAKHQARKIESTASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSW 271
Query: 247 LPL---HIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303
LP +I+ + F P ++ + + + NS +NP IYA+ + F + + I+
Sbjct: 272 LPYLVDAVIDAYMNFI-----TPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIV 326
Query: 304 RSHVLR 309
VLR
Sbjct: 327 SGKVLR 332
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 113 bits (282), Expect = 4e-25
Identities = 89/315 (28%), Positives = 149/315 (47%), Gaps = 49/315 (15%)
Query: 2 PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP 61
P + + V L + V+++L N+LV A+ N NL + +FV SLA AD+ V + +
Sbjct: 32 PCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAW 91
Query: 62 FAITIST--------GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYN 113
ITI H + + +S+ SLLAIA+DRY+ I LRY+
Sbjct: 92 ETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYH 151
Query: 114 GLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVP 173
++T R+ IIA W GCG V L+ +
Sbjct: 152 HIMTARRSGAIIAGIWAFC------------------------TGCGI--VFILYSESTY 185
Query: 174 MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQP-LPGERARSTLQKEVHAA 232
+ + FFA L L++ +Y+ +FL AR +K++ + P R R+++Q A
Sbjct: 186 VILCLISMFFAM----LFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQ----GA 237
Query: 233 KSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWL----MYLAIVLSHTNSVVNPFIY 288
++ +++G+F +CW P + CP + ++ MYL +++ NSV++P IY
Sbjct: 238 VTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMC--NSVMDPLIY 295
Query: 289 AYRIREFRQTFRKII 303
A+R +E R+TF++II
Sbjct: 296 AFRSQEMRKTFKEII 310
>gi|46559769 adenosine A3 receptor isoform 1 [Homo sapiens]
Length = 347
Score = 113 bits (282), Expect = 4e-25
Identities = 55/109 (50%), Positives = 77/109 (70%)
Query: 4 MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFA 63
+ + YIT+E+ I + AI+GNVLV V LN +LQ T YF+VSLA ADIAVGVL +P A
Sbjct: 10 LANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLA 69
Query: 64 ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRY 112
I +S G + CLF+ C +L+ T +SI SLLAIA+DRY+ +++ +R+
Sbjct: 70 IVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRF 118
>gi|222080109 orexin receptor 2 [Homo sapiens]
Length = 444
Score = 111 bits (278), Expect = 1e-24
Identities = 98/330 (29%), Positives = 155/330 (46%), Gaps = 46/330 (13%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAIT 65
V I + + V+A++GNVLVC AVW N +++ VTNYF+V+L+ AD+ V + +P +
Sbjct: 56 VLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVD 115
Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125
I+ + C I V S+ +L IA+DR+ AI PL + T RA+ I
Sbjct: 116 ITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSI 173
Query: 126 AICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQG----CGEGQVACLFEDVVPMNYMVYFN 181
I W++S I + P C G + C E ++ P Y + F
Sbjct: 174 VIIWIVSCII-MIPQAIVMECSTVFPGLANKTTLFTVCDERWGG----EIYPKMYHICF- 227
Query: 182 FFACVLVPLLLMLGVYLRIF------------LAARRQLKQME--SQPL-PGERARSTLQ 226
F + PL LM+ YL+IF +R+ K ++ SQP PG+ +S +
Sbjct: 228 FLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMS 287
Query: 227 ------KEVHA----AKSLAIIVGLFALCWLPLHIIN----CFTFFC--PDCSHAPLWLM 270
K++ A A+ L I++ +FA+C+LP+ I+N F F D W
Sbjct: 288 AVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFT 347
Query: 271 YLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
+ + L + NS NP IY + +FR+ F+
Sbjct: 348 F-SHWLVYANSAANPIIYNFLSGKFREEFK 376
>gi|222080095 orexin receptor 1 [Homo sapiens]
Length = 425
Score = 110 bits (276), Expect = 2e-24
Identities = 105/346 (30%), Positives = 154/346 (44%), Gaps = 76/346 (21%)
Query: 8 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAIT 65
V I +A+ V+A++GN LVC AVW N +++ VTNYF+V+L+ AD+ V + +P +
Sbjct: 48 VLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVD 107
Query: 66 ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGII 125
I+ + C I V ++ +L IA+DR+ AI PL + T RA+G I
Sbjct: 108 ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRARGSI 165
Query: 126 AICWVLSFAIGLTPMLGWNNCGQP-KEGKNHSQ---GCGEGQVACLFEDVVPMNYMVYFN 181
W +S AI + P C E N ++ C E +D+ P Y F
Sbjct: 166 LGIWAVSLAI-MVPQAAVMECSSVLPELANRTRLFSVCDERWA----DDLYPKIYHSCF- 219
Query: 182 FFACVLVPLLLMLGVYLRIF--LAARR-----------------QLKQME----SQPLPG 218
F L PL LM Y +IF L R+ QL +E +P P
Sbjct: 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPR 279
Query: 219 ERARSTLQKEVHA----AKSLAIIVGLFALCWLPLHIIN--------------------C 254
RA K++ A AK L +++ +FALC+LP+ ++N C
Sbjct: 280 ARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAC 339
Query: 255 FTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR 300
FTF SH WL+Y NS NP IY + +FR+ F+
Sbjct: 340 FTF-----SH---WLVY-------ANSAANPIIYNFLSGKFREQFK 370
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 105 bits (261), Expect = 1e-22
Identities = 84/302 (27%), Positives = 138/302 (45%), Gaps = 36/302 (11%)
Query: 12 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVL---------AIPF 62
V + I IL N+ V +W YF+ +LA +D+ GV A +
Sbjct: 51 VFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTY 110
Query: 63 AITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 122
+T + F G +F+A +S+FSLLAIAI+RYI + +NG R
Sbjct: 111 KLTPAQWFLR--EGSMFVAL------SASVFSLLAIAIERYITMLKMKLHNGS-NNFRLF 161
Query: 123 GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNF 182
+I+ CWV+S +G P++GWN C +C V+P+ + Y F
Sbjct: 162 LLISACWVISLILGGLPIMGWN--------------CISALSSC--STVLPLYHKHYILF 205
Query: 183 FACVLVPLLLMLGV-YLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGL 241
V LLL + + Y RI+ R + +++ + + +RS+ +K + K++ I++ +
Sbjct: 206 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSS-EKSLALLKTVIIVLSV 264
Query: 242 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRK 301
F CW PL I+ C + L+ +VL+ NS NP IY +E R+ F +
Sbjct: 265 FIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIR 324
Query: 302 II 303
I+
Sbjct: 325 IM 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.140 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,352,316
Number of Sequences: 37866
Number of extensions: 764027
Number of successful extensions: 4464
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 525
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 2676
Number of HSP's gapped (non-prelim): 1072
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.