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Search of human proteins with 5730102
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5730102 transient receptor potential cation channel,
subfamily C, member 6 [Homo sapiens]
(931 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5730102 transient receptor potential cation channel, subfamil... 1863 0.0
gi|9966865 transient receptor potential cation channel, subfamil... 1281 0.0
gi|194733735 transient receptor potential cation channel, subfam... 1251 0.0
gi|4507687 transient receptor potential cation channel, subfamil... 1251 0.0
gi|209863024 transient receptor potential cation channel, subfam... 536 e-152
gi|209863026 transient receptor potential cation channel, subfam... 535 e-152
gi|7706747 transient receptor potential cation channel, subfamil... 535 e-152
gi|6912736 transient receptor potential cation channel, subfamil... 520 e-147
gi|209863030 transient receptor potential cation channel, subfam... 517 e-146
gi|169216484 PREDICTED: similar to transient receptor potential ... 502 e-142
gi|209863028 transient receptor potential cation channel, subfam... 439 e-123
gi|4507685 transient receptor potential cation channel, subfamil... 434 e-121
gi|209863032 transient receptor potential cation channel, subfam... 330 5e-90
gi|239754785 PREDICTED: similar to transient receptor potential ... 290 3e-78
gi|239749299 PREDICTED: similar to transient receptor potential ... 290 3e-78
gi|239743393 PREDICTED: hypothetical protein XP_002342847, parti... 290 3e-78
gi|239509090 PREDICTED: similar to transient receptor potential ... 290 3e-78
gi|4507689 transient receptor potential cation channel, subfamil... 74 8e-13
gi|94538366 transient receptor potential cation channel, subfami... 65 3e-10
gi|148612863 transient receptor potential cation channel, subfam... 62 2e-09
gi|4505835 polycystin 2 [Homo sapiens] 61 6e-09
gi|109689695 transient receptor potential cation channel, subfam... 59 2e-08
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 57 6e-08
gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens] 55 4e-07
gi|18921093 transient receptor potential cation channel, subfami... 54 5e-07
gi|154091312 transient receptor potential cation channel, subfam... 54 5e-07
gi|154091308 transient receptor potential cation channel, subfam... 54 5e-07
gi|154091310 transient receptor potential cation channel, subfam... 54 5e-07
gi|154091320 transient receptor potential cation channel, subfam... 54 5e-07
gi|154091318 transient receptor potential cation channel, subfam... 54 5e-07
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 1863 bits (4826), Expect = 0.0
Identities = 931/931 (100%), Positives = 931/931 (100%)
Query: 1 MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS 60
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS
Sbjct: 1 MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS 60
Query: 61 DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE 120
DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE
Sbjct: 61 DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE 120
Query: 121 CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI 180
CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI
Sbjct: 121 CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI 180
Query: 181 LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR 240
LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR
Sbjct: 181 LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR 240
Query: 241 KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL 300
KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL
Sbjct: 241 KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL 300
Query: 301 SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR 360
SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR
Sbjct: 301 SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR 360
Query: 361 PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL 420
PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL
Sbjct: 361 PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL 420
Query: 421 ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA 480
ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA
Sbjct: 421 ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA 480
Query: 481 KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS 540
KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS
Sbjct: 481 KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS 540
Query: 541 FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA 600
FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA
Sbjct: 541 FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA 600
Query: 601 IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI 660
IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI
Sbjct: 601 IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI 660
Query: 661 GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL 720
GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL
Sbjct: 661 GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL 720
Query: 721 NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL 780
NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL
Sbjct: 721 NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL 780
Query: 781 KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS 840
KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS
Sbjct: 781 KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS 840
Query: 841 EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900
EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE
Sbjct: 841 EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900
Query: 901 EKSQNTEDLAELIRELGEKLSMEPNQEETNR 931
EKSQNTEDLAELIRELGEKLSMEPNQEETNR
Sbjct: 901 EKSQNTEDLAELIRELGEKLSMEPNQEETNR 931
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 1281 bits (3315), Expect = 0.0
Identities = 644/870 (74%), Positives = 732/870 (84%), Gaps = 20/870 (2%)
Query: 58 RGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKM 117
R S + RR T LREKGRR A RGPAYMF+++ TSL+ EEERFLD+AEYGNIPVVRKM
Sbjct: 3 RNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKM 62
Query: 118 LEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIV 177
LEE +LN NCVDYMGQNALQLAV NEHLE+TELLLKKENL+RVGDALLLAISKGYVRIV
Sbjct: 63 LEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIV 122
Query: 178 EAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHT 237
EAIL+HPAFA+G+RL SP + EL+ DDFYAYDEDGTRFSHD+TPIILAAHCQEYEIVH
Sbjct: 123 EAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHI 182
Query: 238 LLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTA 297
LL KGARIERPHDYFCKCN+C +KQ+ DSFSHSRSR+NAYKGLAS AYLSLSSEDPV+TA
Sbjct: 183 LLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTA 242
Query: 298 LELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGD 357
LELSNELA LANIE EFKNDY+KLSMQCKDFVVG+LDLCR+TEEVEAILNGDV D
Sbjct: 243 LELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSD 302
Query: 358 HGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGL 417
H RP+LSR+KLAIKYEVKKFVAHPNCQQQLL++WYENLSGLRQQ++AVKFL V V+IGL
Sbjct: 303 HHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGL 362
Query: 418 PFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETST 477
PFLA+ YW APCSK+G+ +R PFMKFVAHA SFTIFLGLLV+NA+DRFEG K LPNET T
Sbjct: 363 PFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFT 422
Query: 478 DNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIF 537
D KQ+FR+KT+ FSW EMLI+ WV+GMIW+ECKEIW +GP+EY+ LWN+LDFGML+IF
Sbjct: 423 DYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIF 482
Query: 538 AASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG 597
ASF ARFMAF A++AQ +D + L V+L V Y+ AR KW PSDPQIISEG
Sbjct: 483 VASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEG 542
Query: 598 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 657
LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS
Sbjct: 543 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 602
Query: 658 YYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVI 717
YY GAK N AFTTVEESFKTLFW+IFGLSEV SVV+ Y+HKFIENIGYVLYGVYNVTMV+
Sbjct: 603 YYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVV 662
Query: 718 VLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLL 777
VLLNMLIAMIN+S+QEIE+DADVEWKFARAKLW SYF+EGRTLP PFNLVPSPKS +YL+
Sbjct: 663 VLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLI 722
Query: 778 LKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSI 837
+++K + +L + K + D EM +N SK + Q G +
Sbjct: 723 MRIKMCLIKLCKSKAKSCENDLEMGMLN--------------SKFKKTRYQAG------M 762
Query: 838 RSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYE 897
R+SE+ N+ + P +YQKIMKRLIKRYVL+AQ+D+E+DEVNEGELKEIKQDISSLRYE
Sbjct: 763 RNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYE 822
Query: 898 LLEEKSQNTEDLAELIRELGEKLSMEPNQE 927
LLEEKSQ T +LA+LI++L EK N++
Sbjct: 823 LLEEKSQATGELADLIQQLSEKFGKNLNKD 852
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 1251 bits (3238), Expect = 0.0
Identities = 628/857 (73%), Positives = 723/857 (84%), Gaps = 25/857 (2%)
Query: 67 RRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNV 126
RR TV+REKGRR A RGPA+MF+DR TSL+ EEERFLDAAEYGNIPVVRKMLEE +LNV
Sbjct: 81 RRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNV 140
Query: 127 NCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAF 186
NCVDYMGQNALQLAV NEHLE+TELLLKKENL+R+GDALLLAISKGYVRIVEAIL+HP F
Sbjct: 141 NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGF 200
Query: 187 AEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIE 246
A KRL SP + ELQ DDFYAYDEDGTRFS D+TPIILAAHCQ+YE+VH LL KGARIE
Sbjct: 201 AASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 260
Query: 247 RPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAV 306
RPHDYFCKC DC +KQ+HDSFSHSRSRINAYKGLASPAYLSLSSEDPV+TALELSNELA
Sbjct: 261 RPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK 320
Query: 307 LANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR--PNLS 364
LANIEKEFKNDY+KLSMQCKDFVVG+LDLCR++EEVEAILNGD+E+ + + R +LS
Sbjct: 321 LANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLS 380
Query: 365 RLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIY 424
R+KLAIKYEVKKFVAHPNCQQQLL+IWYENLSGLR+QT+A+K LVVL VA+GLPFLA+ Y
Sbjct: 381 RVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGY 440
Query: 425 WFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLF 484
W APCS++GKI+R PFMKFVAHAASF IFLGLLV NA+DRFEG LPN T TD KQ+F
Sbjct: 441 WIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIF 500
Query: 485 RMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIAR 544
R+KT+ F+W EMLI+ WV+GM+W+ECKE+W +GP+EY+ +LWN+LDFGML+IF A+F AR
Sbjct: 501 RVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTAR 560
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
F+AF A+KAQ +D+ DL++VTL ++Y+ AR KW PSDPQIISEGLYAIAVV
Sbjct: 561 FLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV 620
Query: 605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ 664
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV+FIMVF AFMIGMF LYSYY+GAK
Sbjct: 621 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKV 680
Query: 665 NEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLI 724
N AFTTVEESFKTLFW+IFGLSEV SVV+ Y+HKFIENIGYVLYG+YNVTMV+VLLNMLI
Sbjct: 681 NAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLI 740
Query: 725 AMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWI 784
AMINSS+QEIEDD+DVEWKFAR+KLW SYF++G+TLP PF+LVPSPKS Y +++ I
Sbjct: 741 AMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMR----I 796
Query: 785 SELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFH 844
+ ++ Q+D EM N + +L + Q + R E
Sbjct: 797 VNFPKCRRRRLQKDIEMGMGNSKSRLNLF-------------------TQSNSRVFESHS 837
Query: 845 LNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ 904
NS N P +YQ+IMKRLIKRYVL+AQ+DKE+DEVNEGELKEIKQDISSLRYELLE+KSQ
Sbjct: 838 FNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQ 897
Query: 905 NTEDLAELIRELGEKLS 921
TE+LA LI +L EKL+
Sbjct: 898 ATEELAILIHKLSEKLN 914
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 1251 bits (3238), Expect = 0.0
Identities = 628/857 (73%), Positives = 723/857 (84%), Gaps = 25/857 (2%)
Query: 67 RRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNV 126
RR TV+REKGRR A RGPA+MF+DR TSL+ EEERFLDAAEYGNIPVVRKMLEE +LNV
Sbjct: 8 RRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNV 67
Query: 127 NCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAF 186
NCVDYMGQNALQLAV NEHLE+TELLLKKENL+R+GDALLLAISKGYVRIVEAIL+HP F
Sbjct: 68 NCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGF 127
Query: 187 AEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIE 246
A KRL SP + ELQ DDFYAYDEDGTRFS D+TPIILAAHCQ+YE+VH LL KGARIE
Sbjct: 128 AASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIE 187
Query: 247 RPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAV 306
RPHDYFCKC DC +KQ+HDSFSHSRSRINAYKGLASPAYLSLSSEDPV+TALELSNELA
Sbjct: 188 RPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAK 247
Query: 307 LANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR--PNLS 364
LANIEKEFKNDY+KLSMQCKDFVVG+LDLCR++EEVEAILNGD+E+ + + R +LS
Sbjct: 248 LANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLS 307
Query: 365 RLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIY 424
R+KLAIKYEVKKFVAHPNCQQQLL+IWYENLSGLR+QT+A+K LVVL VA+GLPFLA+ Y
Sbjct: 308 RVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGY 367
Query: 425 WFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLF 484
W APCS++GKI+R PFMKFVAHAASF IFLGLLV NA+DRFEG LPN T TD KQ+F
Sbjct: 368 WIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIF 427
Query: 485 RMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIAR 544
R+KT+ F+W EMLI+ WV+GM+W+ECKE+W +GP+EY+ +LWN+LDFGML+IF A+F AR
Sbjct: 428 RVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTAR 487
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
F+AF A+KAQ +D+ DL++VTL ++Y+ AR KW PSDPQIISEGLYAIAVV
Sbjct: 488 FLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV 547
Query: 605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ 664
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV+FIMVF AFMIGMF LYSYY+GAK
Sbjct: 548 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKV 607
Query: 665 NEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLI 724
N AFTTVEESFKTLFW+IFGLSEV SVV+ Y+HKFIENIGYVLYG+YNVTMV+VLLNMLI
Sbjct: 608 NAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLI 667
Query: 725 AMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWI 784
AMINSS+QEIEDD+DVEWKFAR+KLW SYF++G+TLP PF+LVPSPKS Y +++ I
Sbjct: 668 AMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMR----I 723
Query: 785 SELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFH 844
+ ++ Q+D EM N + +L + Q + R E
Sbjct: 724 VNFPKCRRRRLQKDIEMGMGNSKSRLNLF-------------------TQSNSRVFESHS 764
Query: 845 LNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQ 904
NS N P +YQ+IMKRLIKRYVL+AQ+DKE+DEVNEGELKEIKQDISSLRYELLE+KSQ
Sbjct: 765 FNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQ 824
Query: 905 NTEDLAELIRELGEKLS 921
TE+LA LI +L EKL+
Sbjct: 825 ATEELAILIHKLSEKLN 841
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 536 bits (1380), Expect = e-152
Identities = 321/827 (38%), Positives = 461/827 (55%), Gaps = 117/827 (14%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
Query: 450 FTIFLGLLVMNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
+ FL LL++ + DR + + P T + WM I+ WV+G IW
Sbjct: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIW 415
Query: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
Query: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
Query: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESF 675
LGR + DI KF+ I+ +V +AF G+ LY YY K QN AF+T+ E+
Sbjct: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
Query: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 628
Query: 736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGF 795
D AD+EWKFAR KLW SYFEEG TLP PFN++PSPKSL+YL+ KWI +
Sbjct: 629 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWI----------W 674
Query: 796 QEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPR-- 853
+ + + G +G +R+ H + +N R
Sbjct: 675 THLCKKKMRRKPESFGTIG----------------------VRTQ---HRRAADNLRRHH 709
Query: 854 QYQKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
QYQ++M+ L+KRYV D +++E + E KE+KQDISS R+E+L
Sbjct: 710 QYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 756
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 535 bits (1378), Expect = e-152
Identities = 320/825 (38%), Positives = 457/825 (55%), Gaps = 118/825 (14%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
Query: 450 FTIFLGLLVMNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
+ FL LL++ + DR + + P T + WM I+ WV+G IW
Sbjct: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIW 415
Query: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
Query: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
Query: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESF 675
LGR + DI KF+ I+ +V +AF G+ LY YY K QN AF+T+ E+
Sbjct: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
Query: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 628
Query: 736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGF 795
D AD+EWKFAR KLW SYFEEG TLP PFN++PSPKSL+YL+ KWI
Sbjct: 629 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWIW---------- 674
Query: 796 QEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQY 855
+ K +K G+ +G ++R QY
Sbjct: 675 ---THLCKKKMRRKPESFGT-------------IGRRAADNLRRH------------HQY 706
Query: 856 QKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
Q++M+ L+KRYV D +++E + E KE+KQDISS R+E+L
Sbjct: 707 QEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 751
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 535 bits (1378), Expect = e-152
Identities = 320/825 (38%), Positives = 457/825 (55%), Gaps = 118/825 (14%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
Query: 450 FTIFLGLLVMNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
+ FL LL++ + DR + + P T + WM I+ WV+G IW
Sbjct: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIW 415
Query: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
Query: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
Query: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESF 675
LGR + DI KF+ I+ +V +AF G+ LY YY K QN AF+T+ E+
Sbjct: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
Query: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 628
Query: 736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGF 795
D AD+EWKFAR KLW SYFEEG TLP PFN++PSPKSL+YL+ KWI
Sbjct: 629 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWIW---------- 674
Query: 796 QEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQY 855
+ K +K G+ +G ++R QY
Sbjct: 675 ---THLCKKKMRRKPESFGT-------------IGRRAADNLRRH------------HQY 706
Query: 856 QKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
Q++M+ L+KRYV D +++E + E KE+KQDISS R+E+L
Sbjct: 707 QEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 751
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 520 bits (1339), Expect = e-147
Identities = 309/828 (37%), Positives = 461/828 (55%), Gaps = 115/828 (13%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEEC---HSLNVNCVDYMGQNALQLAVANEHLEIT 149
T LS EE+ FL+A E G+ V++ L+E +++N+NC+D +G++AL +A+ NE+LEI
Sbjct: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +LS+ + K++ T ++ +
Sbjct: 87 ELLLNHSVY--VGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSE------ 138
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
F+ D+TPI+LAAH YEI+ L++K I RPH C C +C + DS H
Sbjct: 139 ------FTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP++TA L EL L+ +E EFK +Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGR-PNLSRLKLAIKYEVKKFVAHPNCQQQLL 388
LLD R++ E+E ILN + + D + +L++LK+AIKY K+FVA PNCQQ L
Sbjct: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLA 312
Query: 389 SIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAA 448
++WY+ G R++ VK L + + P L++ Y +P S +G ++ PF+KF+ H A
Sbjct: 313 TLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTA 372
Query: 449 SFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWA 508
S+ FL +L++ A+ T L ++ + +E +I+ WV+G IW
Sbjct: 373 SYLTFLFMLLL-ASQHIVRTDL--------------HVQGPPPTVVEWMILPWVLGFIWG 417
Query: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
E KE+W G EY+ + WN++DF M +++ A+ + +A+
Sbjct: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
Query: 569 KVTLGDNVKYY-NLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 627
VKY + R +W+ P +I+E L+AI+ +LS R+ + AN GPLQISL
Sbjct: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
Query: 628 GRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA--------------KQNEAFTTVEE 673
GR + DI KF+ I+ +V +AF G+ LY YY KQN AF+T+ E
Sbjct: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
Query: 674 SFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQE 733
+ ++LFW++FGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q
Sbjct: 571 TLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL 630
Query: 734 IEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKK 793
I D AD+EWKFAR KLW SYF+EG TLP PFN++PSPKS Y L W + F
Sbjct: 631 IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLY----LGNWFNNTF----- 681
Query: 794 GFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPR 853
K D G ++ ++RS + + +S +
Sbjct: 682 -------------------------CPKRDPD----GRRRRRNLRSFTERNADSLIQ-NQ 711
Query: 854 QYQKIMKRLIKRYV-LQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900
YQ++++ L+KRYV + K + + E KE+KQDISS RYE+L+
Sbjct: 712 HYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLD 759
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 517 bits (1332), Expect = e-146
Identities = 309/804 (38%), Positives = 442/804 (54%), Gaps = 117/804 (14%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
Query: 450 FTIFLGLLVMNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
+ FL LL++ + DR + + P T + WM I+ WV+G IW
Sbjct: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIW 415
Query: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
Query: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
Query: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESF 675
LGR + DI KF+ I+ +V +AF G+ LY YY K QN AF+T+ E+
Sbjct: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
Query: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 628
Query: 736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGF 795
D AD+EWKFAR KLW SYFEEG TLP PFN++PSPKSL+YL+ KWI
Sbjct: 629 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWIW---------- 674
Query: 796 QEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQY 855
+ K +K G+ +G ++R QY
Sbjct: 675 ---THLCKKKMRRKPESFGT-------------IGRRAADNLRRH------------HQY 706
Query: 856 QKIMKRLIKRYVLQAQIDKESDEV 879
Q++M+ L+KRYV D +++EV
Sbjct: 707 QEVMRNLVKRYVAAMIRDAKTEEV 730
>gi|169216484 PREDICTED: similar to transient receptor potential
channel subfamily C member 6 [Homo sapiens]
Length = 304
Score = 502 bits (1293), Expect = e-142
Identities = 250/287 (87%), Positives = 264/287 (91%)
Query: 504 GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDT 563
GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAI +ASFIARF AFWHASKAQSI DA+DT
Sbjct: 17 GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAILSASFIARFRAFWHASKAQSITDASDT 76
Query: 564 LKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPL 623
LKDLTKVTLGDNVKYY+LAR +WDPSDP+++SEGL A+AVVLSFS IA ILPANESFGPL
Sbjct: 77 LKDLTKVTLGDNVKYYSLARREWDPSDPRMVSEGLCAVAVVLSFSGIACILPANESFGPL 136
Query: 624 QISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIF 683
Q+SLG VKDIF+FM+IFIMVFVAFMIGMFNLYSYYI KQNEAFTTVEESFKTLFWA F
Sbjct: 137 QMSLGGAVKDIFRFMLIFIMVFVAFMIGMFNLYSYYIDVKQNEAFTTVEESFKTLFWATF 196
Query: 684 GLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 743
LS VKSVVINY+HKFIENIGYVLYGVY+VTMVIVLLNMLIAMINSS QEIEDDADVEWK
Sbjct: 197 VLSAVKSVVINYSHKFIENIGYVLYGVYDVTMVIVLLNMLIAMINSSLQEIEDDADVEWK 256
Query: 744 FARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQG 790
FARAKLWFS F EGR LPVPFNLVP P SLF LLLKLK WISEL+ G
Sbjct: 257 FARAKLWFSCFGEGRALPVPFNLVPGPGSLFCLLLKLKGWISELYPG 303
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 439 bits (1130), Expect = e-123
Identities = 256/659 (38%), Positives = 372/659 (56%), Gaps = 75/659 (11%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
ELLL VGDALL AI K V VE +L+H + K++
Sbjct: 87 ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
Query: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
D+ + F+ D+TPIILAAH YEI+ L++KG + RPH+ C C +C DS H
Sbjct: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
Query: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
SRSR+N YK LASP+ ++LSSEDP +TA +LS EL L+ +E EFK++Y++LS QCK F
Sbjct: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
Query: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
LLD R++ E+E ILN + + +L+RLKLAIKY K+FVA PNCQQ L S
Sbjct: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
WY+ G R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS
Sbjct: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
Query: 450 FTIFLGLLVMNA--ADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507
+ FL LL++ + DR + + P T +E +I+ WV+G IW
Sbjct: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTI-----------------VEWMILPWVLGFIW 415
Query: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567
E K++W G ++Y+ + WN++DF M +++ A+ + +AF
Sbjct: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
Query: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626
VKY L R WD P +++E L+AIA + S R+ + AN GPLQIS
Sbjct: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
Query: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTVEESF 675
LGR + DI KF+ I+ +V +AF G+ LY YY KQN AF+T+ E+
Sbjct: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
Query: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEI 734
++LFW+IFGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I
Sbjct: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
Score = 47.4 bits (111), Expect = 6e-05
Identities = 23/47 (48%), Positives = 34/47 (72%), Gaps = 1/47 (2%)
Query: 854 QYQKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
QYQ++M+ L+KRYV D +++E + E KE+KQDISS R+E+L
Sbjct: 640 QYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 686
>gi|4507685 transient receptor potential cation channel, subfamily
C, member 1 [Homo sapiens]
Length = 759
Score = 434 bits (1117), Expect = e-121
Identities = 279/825 (33%), Positives = 423/825 (51%), Gaps = 150/825 (18%)
Query: 96 SIEEERFLDAAEYGNIPVVRKMLEECHS--LNVNCVDYMGQNALQLAVANEHLEITELLL 153
++ E+ FL A + G+ +V+K+LEE S LN+NCVD +G+NA+ + + NE+L+I +LLL
Sbjct: 45 TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLL 104
Query: 154 KKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDG 213
G +++E I +P ++
Sbjct: 105 ----------------DYGCQKLMERI-QNPEYST------------------------- 122
Query: 214 TRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSR 273
+ DV P+ILAAH YEI+ LL++ + +PH C+C C+ K K DS HSR R
Sbjct: 123 ---TMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFR 179
Query: 274 INAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLL 333
++ Y+ LASPA + L+ EDP++ A ELS +L L+ +E EF+NDY++L+ QCK F LL
Sbjct: 180 LDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLL 239
Query: 334 DLCRNTEEVEAILNGDVETLQSGDHG----RPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389
RN+ E+E ILN G R NLSRLKLAIKY K+FV+ NCQQ L +
Sbjct: 240 AQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNT 299
Query: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449
+W+ +SG R++ K + VL V I P L+L Y AP S+ G+I+ PFMKF+ H AS
Sbjct: 300 VWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGAS 359
Query: 450 FTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAE 509
+ FL LL + + L+ NE + ++ L+I W+IGMIW++
Sbjct: 360 YFTFLLLLNLYS--------LVYNEDKKNTMGPALER-------IDYLLILWIIGMIWSD 404
Query: 510 CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTK 569
K +W +G +++L E N L F M +++ A+F + +A +K D D
Sbjct: 405 IKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAH---NKFHDFADRKD------- 454
Query: 570 VTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 629
WD P +++EGL+A A VLS+ R+ ++ + GPLQIS+G+
Sbjct: 455 ----------------WDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQ 498
Query: 630 TVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ-------------NEAFTTVEESFK 676
++D KF+ +F++V +F IG+ LY +K+ N+ F + +
Sbjct: 499 MLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCF 558
Query: 677 TLFWAIFGLSEVKSVV--INYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEI 734
LFW IF L+ V V +Y + +G V+ G YNV +VIVL +L+AM++ SFQ I
Sbjct: 559 ALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLI 618
Query: 735 EDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKG 794
+ D EWKFARAKLW SYF++ TLP PFN++PSPK++ Y++ L KWI
Sbjct: 619 ANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWIC--------- 669
Query: 795 FQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQ 854
SH K+ K+Q + +++ D
Sbjct: 670 --------------------SHTSKGKV---KRQNSLKEWRNLKQKRD----------EN 696
Query: 855 YQKIMKRLIKRYVLQAQIDKES-DEVNEGELKEIKQDISSLRYEL 898
YQK+M L+ RY+ + +S D+ L E++QD+S R E+
Sbjct: 697 YQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEI 741
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 330 bits (845), Expect = 5e-90
Identities = 217/636 (34%), Positives = 328/636 (51%), Gaps = 115/636 (18%)
Query: 290 SEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLC-----RNTEEVEA 344
SE + A+E + +V ++E+ Y K+++ C D +G L N E +E
Sbjct: 32 SEKAYLNAVEKGDYASVKKSLEEA--EIYFKININCID-PLGRTALLIAIENENLELIEL 88
Query: 345 ILNGDVETLQSGDHG--RPNLSRLKLAIKYEV----KKFVAHPNCQQQLLSIWYENLSGL 398
+L+ +V + H + + ++L + ++ K+FVA PNCQQ L S WY+ G
Sbjct: 89 LLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQFVAQPNCQQLLASRWYDEFPGW 148
Query: 399 RQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLV 458
R++ AVK + + + P ++ Y AP S +G +R PF+KF+ H AS+ FL LL+
Sbjct: 149 RRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLL 208
Query: 459 MNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQ 516
+ + DR + + P T + WM I+ WV+G IW E K++W
Sbjct: 209 LASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIWGEIKQMWDG 251
Query: 517 GPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNV 576
G ++Y+ + WN++DF M +++ A+ + +AF V
Sbjct: 252 GLQDYIHDWWNLMDFVMNSLYLATISLKIVAF---------------------------V 284
Query: 577 KYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIF 635
KY L R WD P +++E L+AIA + S R+ + AN GPLQISLGR + DI
Sbjct: 285 KYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDIL 344
Query: 636 KFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESFKTLFWAIFG 684
KF+ I+ +V +AF G+ LY YY K QN AF+T+ E+ ++LFW+IFG
Sbjct: 345 KFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG 404
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKF 744
L + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q I D AD+EWKF
Sbjct: 405 LINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKF 464
Query: 745 ARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKI 804
AR KLW SYFEEG TLP PFN++PSPKSL+YL+ KWI + K
Sbjct: 465 ARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWIW-------------THLCKK 507
Query: 805 NEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIK 864
+K G+ +G ++R QYQ++M+ L+K
Sbjct: 508 KMRRKPESFGT-------------IGRRAADNLRRH------------HQYQEVMRNLVK 542
Query: 865 RYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899
RYV D +++E + E KE+KQDISS R+E+L
Sbjct: 543 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 578
Score = 74.7 bits (182), Expect = 4e-13
Identities = 46/118 (38%), Positives = 68/118 (57%), Gaps = 5/118 (4%)
Query: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149
+ LS E+ +L+A E G+ V+K LEE +N+NC+D +G+ AL +A+ NE+LE+
Sbjct: 27 SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
Query: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFY 207
ELLL VGDALL AI K V VE +L+H + K+ P+ +L +Y
Sbjct: 87 ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQFVAQPNCQQLLASRWY 142
>gi|239754785 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 290 bits (743), Expect = 3e-78
Identities = 143/164 (87%), Positives = 151/164 (92%)
Query: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
ECKEIWTQGPKEYLFELWNMLDFGML IF A FIARF AFWHASKAQSIIDANDTLKDLT
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 569 KVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLG 628
+VTLGDNVKYYNLAR +W PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SLG
Sbjct: 64 EVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSLG 123
Query: 629 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVE 672
VKDIF+FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTT++
Sbjct: 124 GAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239749299 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 290 bits (743), Expect = 3e-78
Identities = 143/164 (87%), Positives = 151/164 (92%)
Query: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
ECKEIWTQGPKEYLFELWNMLDFGML IF A FIARF AFWHASKAQSIIDANDTLKDLT
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 569 KVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLG 628
+VTLGDNVKYYNLAR +W PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SLG
Sbjct: 64 EVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSLG 123
Query: 629 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVE 672
VKDIF+FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTT++
Sbjct: 124 GAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239743393 PREDICTED: hypothetical protein XP_002342847, partial
[Homo sapiens]
Length = 182
Score = 290 bits (743), Expect = 3e-78
Identities = 143/164 (87%), Positives = 151/164 (92%)
Query: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
ECKEIWTQGPKEYLFELWNMLDFGML IF A FIARF AFWHASKAQSIIDANDTLKDLT
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 569 KVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLG 628
+VTLGDNVKYYNLAR +W PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SLG
Sbjct: 64 EVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSLG 123
Query: 629 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVE 672
VKDIF+FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTT++
Sbjct: 124 GAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|239509090 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 290 bits (743), Expect = 3e-78
Identities = 143/164 (87%), Positives = 151/164 (92%)
Query: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
ECKEIWTQGPKEYLFELWNMLDFGML IF A FIARF AFWHASKAQSIIDANDTLKDLT
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 569 KVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLG 628
+VTLGDNVKYYNLAR +W PSDP ++SEGL A+AVVLSFS IA ILPANESFGPLQ SLG
Sbjct: 64 EVTLGDNVKYYNLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSLG 123
Query: 629 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVE 672
VKDIF+FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTT++
Sbjct: 124 GAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTLK 167
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 73.6 bits (179), Expect = 8e-13
Identities = 125/591 (21%), Positives = 215/591 (36%), Gaps = 136/591 (23%)
Query: 290 SEDPVMTALELSNELAVLANIEKEFKNDYKKLSM--QCKDFVVGLLDLCRNTEEVEAILN 347
S+D + AL S L L+ E++ + + L++ + + +G+ C +E A
Sbjct: 645 SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERA--- 701
Query: 348 GDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLS---GLRQQTMA 404
+ L + L+LA++ + KFV+H Q L +W+ LS GL + T+
Sbjct: 702 --QKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLC 759
Query: 405 V-KFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAAD 463
+ F ++L I L P ++ P + F + S+ FL L
Sbjct: 760 MLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMV 819
Query: 464 RFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKE--- 520
F+ SW E I W+ ++ E ++++ P E
Sbjct: 820 DFQPVP----------------------SWCECAIYLWLFSLVCEEMRQLFYD-PDECGL 856
Query: 521 ------YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGD 574
Y + WN LD G + +F A R
Sbjct: 857 MKKAALYFSDFWNKLDVGAILLFVAGLTCR------------------------------ 886
Query: 575 NVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFS------RIAYILPANESFGPLQISLG 628
+I LY V+LS R+ +I +++ GP I +
Sbjct: 887 ------------------LIPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVK 928
Query: 629 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEV 688
R +KD+F F+ + + V+F + + + V S+ T+F I G +
Sbjct: 929 RMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGY--I 986
Query: 689 KSVVINYNH-----------------------KFIENIGYVLYGVYNVTMVIVLLNMLIA 725
V N H F E + +L +Y + I+LLN+LIA
Sbjct: 987 DGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIA 1046
Query: 726 MINSSFQEIEDDADVEWKFARAKLWFSYFEEGR-TLPVPFNLVPSPKSLFYLLLKLKKWI 784
M N +FQ++++ D WKF R L Y GR P PF L L +L L +K+ +
Sbjct: 1047 MFNYTFQQVQEHTDQIWKFQRHDLIEEY--HGRPAAPPPFIL------LSHLQLFIKRVV 1098
Query: 785 SELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQP 835
+ K + NK+ + ++ +L L + L +Q ++P
Sbjct: 1099 LKTPAKRHKQLK-----NKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRP 1144
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 65.1 bits (157), Expect = 3e-10
Identities = 90/449 (20%), Positives = 177/449 (39%), Gaps = 103/449 (22%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS+++ + + +EI P K +L E WN+ D ++ F I R
Sbjct: 858 SLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILR 917
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
N Y R+ +Y + ++
Sbjct: 918 LQ----------------------------NQPYMGYGRV-------------IYCVDII 936
Query: 605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQ 664
+ R+ I N+ GP + +G+ + D+ F+VI ++V ++F + + + ++
Sbjct: 937 FWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAI----LHPEE 992
Query: 665 NEAFTTVEESFKTLFWAIFG---LSEVKSVVINYNHKFIENI-----------------G 704
++ F +W I+G ++ + N EN+
Sbjct: 993 KPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLT 1052
Query: 705 YVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPF 764
L Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F + LP P
Sbjct: 1053 PALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHDRPVLPPPM 1111
Query: 765 NLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSL 824
++ ++ ++++L S + ++G QE+ ++ L + S E+L +L
Sbjct: 1112 IIL---SHIYIIIMRL----SGRCRKKREGDQEE-------RDRGLKLFLSDEELKRLHE 1157
Query: 825 DKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGE- 883
++Q Q R ED +S + R + ++ + R +E+NE E
Sbjct: 1158 FEEQC---VQEHFREKEDEQQSSSDERIRVTSERVENMSMRL----------EEINERET 1204
Query: 884 -LKEIKQDISSLRYELLEEKSQNTEDLAE 911
+K Q + LR LEE S + E
Sbjct: 1205 FMKTSLQTV-DLRLAQLEELSNRMVNALE 1232
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/192 (22%), Positives = 89/192 (46%), Gaps = 12/192 (6%)
Query: 598 LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYS 657
+Y + ++ + R+ L N+ GP + +G+ V ++F +VI +V ++F + +
Sbjct: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAI-- 1021
Query: 658 YYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENI-------GYVLYGV 710
+ + ++T ++ +W IFG + + N I I L V
Sbjct: 1022 --LYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAV 1079
Query: 711 YNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSP 770
Y I+++N+LIA N+ + +++ +++ WK+ R +Y E+ LP P ++
Sbjct: 1080 YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEK-PVLPPPLIILSHI 1138
Query: 771 KSLFYLLLKLKK 782
SLF + K +K
Sbjct: 1139 VSLFCCICKRRK 1150
Score = 30.4 bits (67), Expect = 8.0
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 16/113 (14%)
Query: 312 KEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIK 371
K++ ND+ +L+++ LL+ +E A+ + L N + LKLA+
Sbjct: 680 KQYSNDFGQLAVE-------LLEQSFRQDETMAM-----KLLTYELKNWSNSTCLKLAVS 727
Query: 372 YEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIY 424
++ FVAH C Q LLS + +R+ + + V+L++ + L L Y
Sbjct: 728 SRLRPFVAH-TCTQMLLSDMWMGRLNMRKNSW---YKVILSILVPPAILLLEY 776
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 60.8 bits (146), Expect = 6e-09
Identities = 52/221 (23%), Positives = 94/221 (42%), Gaps = 36/221 (16%)
Query: 521 YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYN 580
Y WN LD + I S +A + + S + ++ L+D +++ Y+
Sbjct: 502 YFRSFWNCLD---VVIVVLSVVAIGINIYRTSNVEVLLQF---LEDQNTFPNFEHLAYW- 554
Query: 581 LARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVI 640
QI + A+ V + ++ + N + L ++ R KD+F F ++
Sbjct: 555 -----------QIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIM 603
Query: 641 FIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFI 700
F ++F+A+ +Y + Q + F+T +E T F I G + N I
Sbjct: 604 FFIIFLAYA-----QLAYLVFGTQVDDFSTFQECIFTQFRIILG---------DINFAEI 649
Query: 701 ENIGYVLYGVYNVT----MVIVLLNMLIAMINSSFQEIEDD 737
E VL +Y T M +LLNM +A+IN ++ E++ D
Sbjct: 650 EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSD 690
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 59.3 bits (142), Expect = 2e-08
Identities = 104/523 (19%), Positives = 196/523 (37%), Gaps = 123/523 (23%)
Query: 295 MTALELSNELAVLANIEKEFK--NDYKKLSMQCKDFVVGLLDLCRNTEE--VEAILNGDV 350
+ AL S L LA ++ + + ++L+ + + V L C +++E E +L
Sbjct: 589 LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSC 648
Query: 351 ETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVV 410
E G N L+LA++ + F+A P Q L WY +S + + L +
Sbjct: 649 EAW-----GGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFI 701
Query: 411 LAVAIGLPFLALIYWFAPCSKMGKIM-------RGPFMKFVAHAASFTIFLGLLVMNAAD 463
+ + +G F++ + P K K++ PF+ F + + FL L
Sbjct: 702 IPL-VGCGFVS--FRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLM 758
Query: 464 RFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLF 523
F P E+++ S V + E ++ + G Y
Sbjct: 759 DFHSVPHPP----------------------ELVLYSLVFVLFCDEVRQWYVNGVN-YFT 795
Query: 524 ELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLAR 583
+LWN++D L F A + R H+S S+
Sbjct: 796 DLWNVMDTLGLFYFIAGIVFRL----HSSNKSSLYSGRV--------------------- 830
Query: 584 IKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIM 643
++ + ++ R+ +I + + GP I L R + D+F F+ +F +
Sbjct: 831 --------------IFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAV 876
Query: 644 VFVAFMIGMFNLYSYYIGAKQNEAF------TTVEESFKTLFWAIFGLSEVKSVVINYNH 697
VAF + + +QNE + + E + +F + S+V ++ H
Sbjct: 877 WMVAFGVARQGIL------RQNEQRWRWIFRSVIYEPYLAMFGQV--PSDVDGTTYDFAH 928
Query: 698 ---------------------KFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIED 736
+F E I L +Y ++ I+L+N+L+AM + +++
Sbjct: 929 CTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQE 988
Query: 737 DADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLK 779
+ D WKF R +F E L +PF + + FY+++K
Sbjct: 989 NNDQVWKFQR---YFLVQEYCSRLNIPFPFIVF--AYFYMVVK 1026
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 57.4 bits (137), Expect = 6e-08
Identities = 53/224 (23%), Positives = 97/224 (43%), Gaps = 35/224 (15%)
Query: 521 YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYN 580
Y +WN L+ +L + F+A ++F Q + LK K + +Y
Sbjct: 311 YFKSIWNWLELLLLLL---CFVA--VSFNTYYNVQIFLLLGQLLKSTEKYS-----DFYF 360
Query: 581 LARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVI 640
LA W I + AI + ++ +I + N++ L +L R VKDI F ++
Sbjct: 361 LAC--W-----HIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIM 413
Query: 641 FIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFI 700
F ++F A+ + + Q + F+T + S F + G ++N I
Sbjct: 414 FFIIFFAYA-----QLGFLVFGSQVDDFSTFQNSIFAQFRIVLG---------DFNFAGI 459
Query: 701 ENIGYVLYGVYNVTMVI----VLLNMLIAMINSSFQEIEDDADV 740
+ +L +Y +T + VLLNM +A+IN ++ E++ D +
Sbjct: 460 QQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSI 503
>gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
Length = 805
Score = 54.7 bits (130), Expect = 4e-07
Identities = 40/142 (28%), Positives = 69/142 (48%), Gaps = 18/142 (12%)
Query: 600 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 659
A+ + ++ +I + N++ L +L R KDI F V+F +VF A+ Y
Sbjct: 443 AVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYA-----QLGYL 497
Query: 660 IGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMV--- 716
+ Q E F+T + T F I G ++++ I+N +L Y VT V
Sbjct: 498 LFGTQVENFSTFIKCIFTQFRIILG---------DFDYNAIDNANRILGPAYFVTYVFFV 548
Query: 717 -IVLLNMLIAMINSSFQEIEDD 737
VLLNM +A+IN ++ E++++
Sbjct: 549 FFVLLNMFLAIINDTYSEVKEE 570
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/259 (18%), Positives = 103/259 (39%), Gaps = 53/259 (20%)
Query: 514 WTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLG 573
+TQ K ++ E WN+ + + +F+A F+ R+
Sbjct: 898 FTQKVKVWISEYWNLTETVAIGLFSAGFVLRW---------------------------- 929
Query: 574 DNVKYYNLARIKWDPSDPQIISEG--LYAIAVVLSFSRIAYILPANESFGPLQISLGRTV 631
DP + G +Y I ++ FSR+ N+ GP + +
Sbjct: 930 ---------------GDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMT 974
Query: 632 KDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSV 691
++F ++I +V ++F + + S K+ +++ + +W I+G +
Sbjct: 975 ANMFYIVIIMAIVLLSFGVARKAILS----PKEPPSWSLARDIVFEPYWMIYGEVYAGEI 1030
Query: 692 VINYNHKFIENIGYV---LYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAK 748
+ + ++ L VY I+++N+LIA N+ + ++E ++ WK+ R +
Sbjct: 1031 DVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYR 1090
Query: 749 LWFSYFEEGRTLPVPFNLV 767
+Y E+ LP P L+
Sbjct: 1091 YIMTYHEK-PWLPPPLILL 1108
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 54.3 bits (129), Expect = 5e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 759 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 818
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
D S+G +Y +
Sbjct: 819 LQ-------------------------------------------DQPFRSDGRVIYCVN 835
Query: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 836 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 884
Query: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
+Q F E S+K +W I+G + G ++
Sbjct: 885 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 944
Query: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 945 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 1003
Query: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 1004 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1052
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 715 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 773
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 774 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 816
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 54.3 bits (129), Expect = 5e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 772 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 831
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
D S+G +Y +
Sbjct: 832 LQ-------------------------------------------DQPFRSDGRVIYCVN 848
Query: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 849 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 897
Query: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
+Q F E S+K +W I+G + G ++
Sbjct: 898 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 957
Query: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 958 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 1016
Query: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 1017 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1065
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 728 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 786
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 787 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 829
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 54.3 bits (129), Expect = 5e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 762 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 821
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
D S+G +Y +
Sbjct: 822 LQ-------------------------------------------DQPFRSDGRVIYCVN 838
Query: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 839 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 887
Query: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
+Q F E S+K +W I+G + G ++
Sbjct: 888 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 947
Query: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 948 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 1006
Query: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 1007 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1055
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 718 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 776
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 777 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 819
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 54.3 bits (129), Expect = 5e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 747 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 806
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
D S+G +Y +
Sbjct: 807 LQ-------------------------------------------DQPFRSDGRVIYCVN 823
Query: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 824 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 872
Query: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
+Q F E S+K +W I+G + G ++
Sbjct: 873 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 932
Query: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 933 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 991
Query: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 992 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1040
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 703 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 761
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 762 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 804
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 54.3 bits (129), Expect = 5e-07
Identities = 70/349 (20%), Positives = 133/349 (38%), Gaps = 89/349 (25%)
Query: 492 SWMEMLIISWVIGMIWAECKEIWTQGP-------KEYLFELWNMLDFGMLAIFAASFIAR 544
S E ++IS++ + + +EI P K +L E WN+ D + +F+ I R
Sbjct: 737 STQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILR 796
Query: 545 FMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEG--LYAIA 602
D S+G +Y +
Sbjct: 797 LQ-------------------------------------------DQPFRSDGRVIYCVN 813
Query: 603 VVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA 662
++ + R+ I N+ GP + +G+ + D+ F++I ++V ++F + A
Sbjct: 814 IIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV-----------A 862
Query: 663 KQNEAFTTVEESFKTL-------FWAIFGLSEVKSVVINYNHKFIENIGYVLY------- 708
+Q F E S+K +W I+G + G ++
Sbjct: 863 RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTG 922
Query: 709 --------GVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTL 760
Y + I+L+N+LIA+ N++F E++ ++ WKF R +L + F E L
Sbjct: 923 AWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT-FHERPVL 981
Query: 761 PVPFNLVPSPKSLF-YLLLKLKKWISELFQGH--KKGFQEDAEMNKINE 806
P P + +F +L + +K S+ + K F D E+ K+++
Sbjct: 982 PPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHD 1030
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 625 ISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG 684
I LGR + + + ++ + IG L++Y + K E + + +E + G
Sbjct: 693 IPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKM-ERWPSTQEWIVISYIFTLG 751
Query: 685 LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMI 727
+ +++ ++++ K ++ + L +NVT +I +L + MI
Sbjct: 752 IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMI 794
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,811,037
Number of Sequences: 37866
Number of extensions: 1437637
Number of successful extensions: 5487
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 4926
Number of HSP's gapped (non-prelim): 598
length of query: 931
length of database: 18,247,518
effective HSP length: 112
effective length of query: 819
effective length of database: 14,006,526
effective search space: 11471344794
effective search space used: 11471344794
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.