Guide to the Human Genome
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Search of human proteins with 56550047

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56550047 uveal autoantigen with coiled-coil domains and
ankyrin repeats isoform 2 [Homo sapiens]
         (1403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...  2721   0.0  
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...  2689   0.0  
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]        353   6e-97
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]        351   3e-96
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]        351   3e-96
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]        351   3e-96
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]        351   3e-96
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]        351   3e-96
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                  257   6e-68
gi|121582655 ankyrin repeat domain 35 [Homo sapiens]                  197   8e-50
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    182   2e-45
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   181   3e-45
gi|71061468 centromere protein E [Homo sapiens]                       178   3e-44
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   177   6e-44
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   176   1e-43
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            174   7e-43
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   172   3e-42
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   172   3e-42
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    171   3e-42
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   171   3e-42
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   171   3e-42
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   170   1e-41
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   166   1e-40
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                  165   3e-40
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   160   6e-39
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   160   6e-39
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   160   6e-39
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   160   6e-39
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   159   1e-38
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      157   5e-38

>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 2721 bits (7052), Expect = 0.0
 Identities = 1403/1403 (100%), Positives = 1403/1403 (100%)

Query: 1    MMNCWFSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFH 60
            MMNCWFSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFH
Sbjct: 1    MMNCWFSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFH 60

Query: 61   VVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQ 120
            VVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQ
Sbjct: 61   VVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQ 120

Query: 121  GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADV 180
            GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADV
Sbjct: 121  GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADV 180

Query: 181  NSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLK 240
            NSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLK
Sbjct: 181  NSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLK 240

Query: 241  TASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKI 300
            TASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKI
Sbjct: 241  TASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKI 300

Query: 301  QQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRF 360
            QQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRF
Sbjct: 301  QQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRF 360

Query: 361  KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ 420
            KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ
Sbjct: 361  KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ 420

Query: 421  TSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIK 480
            TSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIK
Sbjct: 421  TSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIK 480

Query: 481  QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 540
            QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY
Sbjct: 481  QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 540

Query: 541  EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 600
            EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEME
Sbjct: 541  EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 600

Query: 601  GQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELEN 660
            GQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELEN
Sbjct: 601  GQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELEN 660

Query: 661  VKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQA 720
            VKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQA
Sbjct: 661  VKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQA 720

Query: 721  HNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLS 780
            HNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLS
Sbjct: 721  HNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLS 780

Query: 781  KDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK 840
            KDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK
Sbjct: 781  KDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK 840

Query: 841  MMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN 900
            MMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN
Sbjct: 841  MMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN 900

Query: 901  TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 960
            TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE
Sbjct: 901  TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 960

Query: 961  LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020
            LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL
Sbjct: 961  LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020

Query: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080
            KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN
Sbjct: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080

Query: 1081 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140
            AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH
Sbjct: 1081 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140

Query: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
            QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ
Sbjct: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200

Query: 1201 ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1260
            ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD
Sbjct: 1201 ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1260

Query: 1261 EKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1320
            EKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ
Sbjct: 1261 EKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1320

Query: 1321 ALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQ 1380
            ALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQ
Sbjct: 1321 ALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQ 1380

Query: 1381 GHMDEDVQEALLQIIQMRQGLVC 1403
            GHMDEDVQEALLQIIQMRQGLVC
Sbjct: 1381 GHMDEDVQEALLQIIQMRQGLVC 1403


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 2689 bits (6969), Expect = 0.0
 Identities = 1390/1390 (100%), Positives = 1390/1390 (100%)

Query: 14   HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA 73
            HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA
Sbjct: 27   HAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNA 86

Query: 74   ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 133
            ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC
Sbjct: 87   ILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADC 146

Query: 134  PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 193
            PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML
Sbjct: 147  PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML 206

Query: 194  GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW 253
            GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW
Sbjct: 207  GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELW 266

Query: 254  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
            KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG
Sbjct: 267  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 326

Query: 314  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
            LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH
Sbjct: 327  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 386

Query: 374  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
            FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL
Sbjct: 387  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 446

Query: 434  EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM 493
            EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM
Sbjct: 447  EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM 506

Query: 494  YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ 553
            YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ
Sbjct: 507  YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQ 566

Query: 554  IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 613
            IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS
Sbjct: 567  IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 626

Query: 614  IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 673
            IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE
Sbjct: 627  IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 686

Query: 674  HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 733
            HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP
Sbjct: 687  HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 746

Query: 734  LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP 793
            LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP
Sbjct: 747  LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPP 806

Query: 794  EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 853
            EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE
Sbjct: 807  EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 866

Query: 854  EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 913
            EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA
Sbjct: 867  EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 926

Query: 914  EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA 973
            EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA
Sbjct: 927  EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYA 986

Query: 974  PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1033
            PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD
Sbjct: 987  PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1046

Query: 1034 KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1093
            KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL
Sbjct: 1047 KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1106

Query: 1094 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153
            LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL
Sbjct: 1107 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166

Query: 1154 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1213
            AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL
Sbjct: 1167 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1226

Query: 1214 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1273
            SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI
Sbjct: 1227 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1286

Query: 1274 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
            KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG
Sbjct: 1287 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1346

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1393
            NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ
Sbjct: 1347 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1406

Query: 1394 IIQMRQGLVC 1403
            IIQMRQGLVC
Sbjct: 1407 IIQMRQGLVC 1416


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score =  353 bits (906), Expect = 6e-97
 Identities = 300/1110 (27%), Positives = 521/1110 (46%), Gaps = 174/1110 (15%)

Query: 5    WFSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTS 64
            W S   K +   +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +
Sbjct: 8    WLSA--KEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAA 65

Query: 65   KGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTA 124
            KG++ECL  ++ HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TA
Sbjct: 66   KGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTA 125

Query: 125  LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 184
            LH AA   C  ++Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+
Sbjct: 126  LHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 185

Query: 185  KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----- 239
            K  RTALML CE G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL     
Sbjct: 186  KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 245

Query: 240  ------------------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQ 281
                              K +SE +   ++     P +    L+ +    ++ S     +
Sbjct: 246  QDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 305

Query: 282  NIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAA 341
              + +       K  +  I++ +  L D   G       + ++    E++++ L SLL A
Sbjct: 306  --ESVFFAEPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQA 357

Query: 342  KEKQ---HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCT 396
            K      H + L+     K+  K  E+D L   S+ S + +    L K G+    DS+ +
Sbjct: 358  KVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-S 414

Query: 397  SPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNEL 454
            SP +  H            SL   T+ ++  I  L++ L+ ++   ES++ +R +LQ EL
Sbjct: 415  SPSVLIH------------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVEL 462

Query: 455  AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHL 514
              + AE   + L    + E+S +    L   LK+ Q +  E+  +V  +Q     +K  L
Sbjct: 463  QSRRAE--LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGL 513

Query: 515  TSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEE 574
             S  +  N+    EL+   +++ V                          K+D    +EE
Sbjct: 514  VSPESMDNYSHFHELRVTEEEINV-------------------------LKQDLQNALEE 548

Query: 575  NKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKA 634
            +              E+   KV E+E +  E      +  P E++E MKSS  + +    
Sbjct: 549  S--------------ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMN 594

Query: 635  KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE 694
            K+   +  +++++  EI +LK   + +K+++ Q    +E E +K  + +   EL K+++E
Sbjct: 595  KEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSE 650

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
            L+   +  Q E+E  Y   K L++    +T E    Y+        K  H+ ++   N  
Sbjct: 651  LSQLYKEAQAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVS 694

Query: 755  LLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL 814
                    +E K +  K+L E   L + V   +   V   +H + I  L++   E+++++
Sbjct: 695  RAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKI 754

Query: 815  SELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVK 874
            S LK+     + ++  L  +    K  M++  VP  ++E+++ +L   ++    +L +  
Sbjct: 755  SNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV 814

Query: 875  KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNA 934
            K+ E ++ E V+I+ +   +KR  EN Q  +K+                    K Q+ N 
Sbjct: 815  KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN- 853

Query: 935  EILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE--- 991
            E+L  +++ QEE+    AE+K   +    ++             E+ ++K     KE   
Sbjct: 854  ELLQKFQQAQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTK 896

Query: 992  LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEME 1045
            LK+ L+  +Q  S S    K+  Q+ + L++++  LQ  L +      + + + + H + 
Sbjct: 897  LKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 955

Query: 1046 RALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
                +  +++ K LK   Q  T  KN  +K
Sbjct: 956  AVQGQMDEDVQKVLK---QILTMCKNQSQK 982



 Score =  232 bits (591), Expect = 2e-60
 Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)

Query: 644  HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
            H   LSE   I+ L     +  A L    KP++H+QV     ++SG   K+      I+ 
Sbjct: 226  HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 285

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
              L + +  + I    L  K   E         K     ++ ++D         D L   
Sbjct: 286  TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 339

Query: 755  LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
             LD++ +  ++ L      ++  L L N  L     +L+       + +    +  S   
Sbjct: 340  -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 395

Query: 809  ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
            +L   L +  +    D +      IH+L    T+       L++++ +    +++ E  +
Sbjct: 396  DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 455

Query: 857  MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
              L   L     EL+     ++ +   D++Q+  + + K E   + + + Q Q+K   +S
Sbjct: 456  KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 515

Query: 912  LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
                      HE +++    ++ K    NA  L    + +E++  L  E K  ++E  T+
Sbjct: 516  PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 571

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
             +       P+  +EE +  + +  + +  + +   +KY  ++EE+ K K   D LK ++
Sbjct: 572  IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 622

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
                 D         ++ +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++
Sbjct: 623  TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 670

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
             E +  + + + +H  L Q+  + ++        ++ L  M+  Y K    +T+L QL++
Sbjct: 671  LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 724

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
             QK +SV + EHLQ+          ++  +   +E   +K  EV+KL+ ++   K A+  
Sbjct: 725  AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 782

Query: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
              T  +V  S Y+  +S LE+++S L  KL    ++ E+V  EV+  + +    K EKE 
Sbjct: 783  --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 840

Query: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
            +     S EQE+ +  ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+A
Sbjct: 841  IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 900

Query: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
            LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG
Sbjct: 901  LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 959

Query: 1382 HMDEDVQEALLQIIQM 1397
             MDEDVQ+ L QI+ M
Sbjct: 960  QMDEDVQKVLKQILTM 975


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score =  351 bits (900), Expect = 3e-96
 Identities = 297/1098 (27%), Positives = 517/1098 (47%), Gaps = 172/1098 (15%)

Query: 17   DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
            +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +KG++ECL  ++ 
Sbjct: 7    EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 66

Query: 77   HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
            HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TALH AA   C  +
Sbjct: 67   HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 126

Query: 137  IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
            +Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+K  RTALML CE
Sbjct: 127  VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 186

Query: 197  YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
             G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL                 
Sbjct: 187  IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 246

Query: 240  ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
                  K +SE +   ++     P +    L+ +    ++ S     +  + +       
Sbjct: 247  QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 304

Query: 294  KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
            K  +  I++ +  L D   G       + ++    E++++ L SLL AK      H + L
Sbjct: 305  KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 358

Query: 351  RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
            +     K+  K  E+D L   S+ S + +    L K G+    DS+ +SP +  H     
Sbjct: 359  QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 410

Query: 409  MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
                   SL   T+ ++  I  L++ L+ ++   ES++ +R +LQ EL  + AE   + L
Sbjct: 411  -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 461

Query: 467  ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
                + E+S +    L   LK+ Q +  E+  +V  +Q     +K  L S  +  N+   
Sbjct: 462  NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 514

Query: 527  EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
             EL+   +++ V                          K+D    +EE+           
Sbjct: 515  HELRVTEEEINV-------------------------LKQDLQNALEES----------- 538

Query: 587  MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
               E+   KV E+E +  E      +  P E++E MKSS  + +    K+   +  ++++
Sbjct: 539  ---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 595

Query: 647  SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
            +  EI +LK   + +K+++ Q    +E E +K  + +   EL K+++EL+   +  Q E+
Sbjct: 596  AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 651

Query: 707  EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
            E  Y   K L++    +T E    Y+        K  H+ ++   N          +E K
Sbjct: 652  ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 695

Query: 767  LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
             +  K+L E   L + V   +   V   +H + I  L++   E+++++S LK+     + 
Sbjct: 696  SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 755

Query: 827  KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
            ++  L  +    K  M++  VP  ++E+++ +L   ++    +L +  K+ E ++ E V+
Sbjct: 756  EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 815

Query: 887  IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
            I+ +   +KR  EN Q  +K+                    K Q+ N E+L  +++ QEE
Sbjct: 816  IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 854

Query: 947  IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
            +    AE+K   +    ++             E+ ++K     KE   LK+ L+  +Q  
Sbjct: 855  L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 896

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
            S S    K+  Q+ + L++++  LQ  L +      + + + + H +     +  +++ K
Sbjct: 897  SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 956

Query: 1058 QLKDLSQKYTEVKNVKEK 1075
             LK   Q  T  KN  +K
Sbjct: 957  VLK---QILTMCKNQSQK 971



 Score =  232 bits (591), Expect = 2e-60
 Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)

Query: 644  HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
            H   LSE   I+ L     +  A L    KP++H+QV     ++SG   K+      I+ 
Sbjct: 215  HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 274

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
              L + +  + I    L  K   E         K     ++ ++D         D L   
Sbjct: 275  TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 328

Query: 755  LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
             LD++ +  ++ L      ++  L L N  L     +L+       + +    +  S   
Sbjct: 329  -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 384

Query: 809  ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
            +L   L +  +    D +      IH+L    T+       L++++ +    +++ E  +
Sbjct: 385  DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 444

Query: 857  MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
              L   L     EL+     ++ +   D++Q+  + + K E   + + + Q Q+K   +S
Sbjct: 445  KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 504

Query: 912  LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
                      HE +++    ++ K    NA  L    + +E++  L  E K  ++E  T+
Sbjct: 505  PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 560

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
             +       P+  +EE +  + +  + +  + +   +KY  ++EE+ K K   D LK ++
Sbjct: 561  IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 611

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
                 D         ++ +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++
Sbjct: 612  TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 659

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
             E +  + + + +H  L Q+  + ++        ++ L  M+  Y K    +T+L QL++
Sbjct: 660  LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 713

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
             QK +SV + EHLQ+          ++  +   +E   +K  EV+KL+ ++   K A+  
Sbjct: 714  AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 771

Query: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
              T  +V  S Y+  +S LE+++S L  KL    ++ E+V  EV+  + +    K EKE 
Sbjct: 772  --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 829

Query: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
            +     S EQE+ +  ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+A
Sbjct: 830  IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 889

Query: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
            LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG
Sbjct: 890  LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 948

Query: 1382 HMDEDVQEALLQIIQM 1397
             MDEDVQ+ L QI+ M
Sbjct: 949  QMDEDVQKVLKQILTM 964


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score =  351 bits (900), Expect = 3e-96
 Identities = 296/1075 (27%), Positives = 518/1075 (48%), Gaps = 155/1075 (14%)

Query: 17   DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
            +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +KG++ECL  ++ 
Sbjct: 15   EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74

Query: 77   HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
            HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TALH AA   C  +
Sbjct: 75   HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134

Query: 137  IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
            +Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+K  RTALML CE
Sbjct: 135  VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194

Query: 197  YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKG 256
             G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL +     ++  +L  K 
Sbjct: 195  IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS---KISQDADL--KT 249

Query: 257  PSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQL 316
            P+ + + L+ +    ++ S     +  + +       K  +  I++ +  L D   G   
Sbjct: 250  PT-KPKQLSDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG--- 303

Query: 317  QLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSH 373
                + ++    E++++ L SLL AK      H + L+     K+  K  E+D L   S+
Sbjct: 304  ---ADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSY 358

Query: 374  FSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--L 429
             S + +    L K G+    DS+ +SP +  H            SL   T+ ++  I  L
Sbjct: 359  HSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQL 405

Query: 430  KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
            ++ L+ ++   ES++ +R +LQ EL  + AE   + L    + E+S +    L   LK+ 
Sbjct: 406  QEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKET 459

Query: 490  QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 549
            Q +  E+  +V  +Q     +K  L S  +  N+    EL+   +++ V           
Sbjct: 460  QSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV----------- 505

Query: 550  LRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK 609
                           K+D    +EE+              E+   KV E+E +  E    
Sbjct: 506  --------------LKQDLQNALEES--------------ERNKEKVRELEEKLVEREKG 537

Query: 610  LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHV 669
              +  P E++E MKSS  + +    K+   +  +++++  EI +LK   + +K+++ Q  
Sbjct: 538  TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEA 594

Query: 670  KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 729
              +E E +K  + +   EL K+++EL+   +  Q E+E  Y   K L++    +T E   
Sbjct: 595  S-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE--- 645

Query: 730  HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETV 789
             Y+        K  H+ ++   N          +E K +  K+L E   L + V   +  
Sbjct: 646  -YI-------HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKEN 697

Query: 790  FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 849
             V   +H + I  L++   E+++++S LK+     + ++  L  +    K  M++  VP 
Sbjct: 698  SVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPR 757

Query: 850  KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 909
             ++E+++ +L   ++    +L +  K+ E ++ E V+I+ +   +KR  EN Q  +K+  
Sbjct: 758  SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-- 815

Query: 910  ISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 969
                              K Q+ N E+L  +++ QEE+    AE+K   +    ++    
Sbjct: 816  ------------------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE---- 848

Query: 970  VKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1026
                     E+ ++K     KE   LK+ L+  +Q  S S    K+  Q+ + L++++  
Sbjct: 849  ---------EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQ 898

Query: 1027 LQKDLRD------KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
            LQ  L +      + + + + H +     +  +++ K LK   Q  T  KN  +K
Sbjct: 899  LQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 950



 Score =  228 bits (582), Expect = 2e-59
 Identities = 176/660 (26%), Positives = 329/660 (49%), Gaps = 64/660 (9%)

Query: 750  DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEII--ALKSNI 807
            +L  KL   + K  E  L  +        L   + +      P  K    ++  +L  + 
Sbjct: 336  ELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKST 395

Query: 808  VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 867
             +   ++ +L++   + Q+++ +  +E   L+       V +++     + LN+T     
Sbjct: 396  TDNDVRIQQLQEILQDLQKRLESSEAERKQLQ-------VELQSRRAELVCLNNT----- 443

Query: 868  RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE-------HEAKMS 920
                ++ +   D++Q+  + + K E   + + + Q Q+K   +S          HE +++
Sbjct: 444  ----EISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 499

Query: 921  SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE 980
                ++ K    NA  L    + +E++  L  E K  ++E  T+ +       P+  +EE
Sbjct: 500  EEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTVIK------PPVEEYEE 549

Query: 981  CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1040
             +  + +  + +  + +   +KY  ++EE+ K K   D LK ++     D         +
Sbjct: 550  MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEASD---------E 597

Query: 1041 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1100
            + +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++ E +  + + + +H  
Sbjct: 598  AEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654

Query: 1101 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1160
            L Q+  + ++        ++ L  M+  Y K    +T+L QL++ QK +SV + EHLQ+ 
Sbjct: 655  LMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVI 708

Query: 1161 EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK 1220
                     ++  +   +E   +K  EV+KL+ ++   K A+    T  +V  S Y+  +
Sbjct: 709  TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM----TDAMVPRSSYEKLQ 764

Query: 1221 SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF---SIEQEIKDQK 1277
            S LE+++S L  KL    ++ E+V  EV+  + +    K EKE +     S EQE+ +  
Sbjct: 765  SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 824

Query: 1278 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1337
            ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+ALN LSQL+Y++ + +K
Sbjct: 825  QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS-SK 883

Query: 1338 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1397
            RQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG MDEDVQ+ L QI+ M
Sbjct: 884  RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score =  351 bits (900), Expect = 3e-96
 Identities = 297/1098 (27%), Positives = 517/1098 (47%), Gaps = 172/1098 (15%)

Query: 17   DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
            +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +KG++ECL  ++ 
Sbjct: 15   EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74

Query: 77   HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
            HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TALH AA   C  +
Sbjct: 75   HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134

Query: 137  IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
            +Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+K  RTALML CE
Sbjct: 135  VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194

Query: 197  YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
             G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL                 
Sbjct: 195  IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 254

Query: 240  ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
                  K +SE +   ++     P +    L+ +    ++ S     +  + +       
Sbjct: 255  QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 312

Query: 294  KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
            K  +  I++ +  L D   G       + ++    E++++ L SLL AK      H + L
Sbjct: 313  KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 366

Query: 351  RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
            +     K+  K  E+D L   S+ S + +    L K G+    DS+ +SP +  H     
Sbjct: 367  QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 418

Query: 409  MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
                   SL   T+ ++  I  L++ L+ ++   ES++ +R +LQ EL  + AE   + L
Sbjct: 419  -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 469

Query: 467  ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
                + E+S +    L   LK+ Q +  E+  +V  +Q     +K  L S  +  N+   
Sbjct: 470  NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 522

Query: 527  EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
             EL+   +++ V                          K+D    +EE+           
Sbjct: 523  HELRVTEEEINV-------------------------LKQDLQNALEES----------- 546

Query: 587  MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
               E+   KV E+E +  E      +  P E++E MKSS  + +    K+   +  ++++
Sbjct: 547  ---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603

Query: 647  SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
            +  EI +LK   + +K+++ Q    +E E +K  + +   EL K+++EL+   +  Q E+
Sbjct: 604  AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 659

Query: 707  EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
            E  Y   K L++    +T E    Y+        K  H+ ++   N          +E K
Sbjct: 660  ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 703

Query: 767  LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
             +  K+L E   L + V   +   V   +H + I  L++   E+++++S LK+     + 
Sbjct: 704  SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 763

Query: 827  KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
            ++  L  +    K  M++  VP  ++E+++ +L   ++    +L +  K+ E ++ E V+
Sbjct: 764  EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 823

Query: 887  IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
            I+ +   +KR  EN Q  +K+                    K Q+ N E+L  +++ QEE
Sbjct: 824  IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 862

Query: 947  IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
            +    AE+K   +    ++             E+ ++K     KE   LK+ L+  +Q  
Sbjct: 863  L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 904

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
            S S    K+  Q+ + L++++  LQ  L +      + + + + H +     +  +++ K
Sbjct: 905  SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 964

Query: 1058 QLKDLSQKYTEVKNVKEK 1075
             LK   Q  T  KN  +K
Sbjct: 965  VLK---QILTMCKNQSQK 979



 Score =  232 bits (591), Expect = 2e-60
 Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)

Query: 644  HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
            H   LSE   I+ L     +  A L    KP++H+QV     ++SG   K+      I+ 
Sbjct: 223  HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
              L + +  + I    L  K   E         K     ++ ++D         D L   
Sbjct: 283  TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336

Query: 755  LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
             LD++ +  ++ L      ++  L L N  L     +L+       + +    +  S   
Sbjct: 337  -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392

Query: 809  ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
            +L   L +  +    D +      IH+L    T+       L++++ +    +++ E  +
Sbjct: 393  DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 857  MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
              L   L     EL+     ++ +   D++Q+  + + K E   + + + Q Q+K   +S
Sbjct: 453  KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512

Query: 912  LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
                      HE +++    ++ K    NA  L    + +E++  L  E K  ++E  T+
Sbjct: 513  PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
             +       P+  +EE +  + +  + +  + +   +KY  ++EE+ K K   D LK ++
Sbjct: 569  IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
                 D         ++ +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++
Sbjct: 620  TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
             E +  + + + +H  L Q+  + ++        ++ L  M+  Y K    +T+L QL++
Sbjct: 668  LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
             QK +SV + EHLQ+          ++  +   +E   +K  EV+KL+ ++   K A+  
Sbjct: 722  AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779

Query: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
              T  +V  S Y+  +S LE+++S L  KL    ++ E+V  EV+  + +    K EKE 
Sbjct: 780  --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837

Query: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
            +     S EQE+ +  ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+A
Sbjct: 838  IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897

Query: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
            LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG
Sbjct: 898  LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956

Query: 1382 HMDEDVQEALLQIIQM 1397
             MDEDVQ+ L QI+ M
Sbjct: 957  QMDEDVQKVLKQILTM 972


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score =  351 bits (900), Expect = 3e-96
 Identities = 297/1098 (27%), Positives = 517/1098 (47%), Gaps = 172/1098 (15%)

Query: 17   DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
            +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +KG++ECL  ++ 
Sbjct: 15   EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74

Query: 77   HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
            HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TALH AA   C  +
Sbjct: 75   HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134

Query: 137  IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
            +Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+K  RTALML CE
Sbjct: 135  VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194

Query: 197  YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
             G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL                 
Sbjct: 195  IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 254

Query: 240  ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
                  K +SE +   ++     P +    L+ +    ++ S     +  + +       
Sbjct: 255  QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 312

Query: 294  KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
            K  +  I++ +  L D   G       + ++    E++++ L SLL AK      H + L
Sbjct: 313  KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 366

Query: 351  RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
            +     K+  K  E+D L   S+ S + +    L K G+    DS+ +SP +  H     
Sbjct: 367  QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 418

Query: 409  MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
                   SL   T+ ++  I  L++ L+ ++   ES++ +R +LQ EL  + AE   + L
Sbjct: 419  -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 469

Query: 467  ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
                + E+S +    L   LK+ Q +  E+  +V  +Q     +K  L S  +  N+   
Sbjct: 470  NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 522

Query: 527  EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
             EL+   +++ V                          K+D    +EE+           
Sbjct: 523  HELRVTEEEINV-------------------------LKQDLQNALEES----------- 546

Query: 587  MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
               E+   KV E+E +  E      +  P E++E MKSS  + +    K+   +  ++++
Sbjct: 547  ---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603

Query: 647  SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
            +  EI +LK   + +K+++ Q    +E E +K  + +   EL K+++EL+   +  Q E+
Sbjct: 604  AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 659

Query: 707  EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
            E  Y   K L++    +T E    Y+        K  H+ ++   N          +E K
Sbjct: 660  ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 703

Query: 767  LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
             +  K+L E   L + V   +   V   +H + I  L++   E+++++S LK+     + 
Sbjct: 704  SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 763

Query: 827  KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
            ++  L  +    K  M++  VP  ++E+++ +L   ++    +L +  K+ E ++ E V+
Sbjct: 764  EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 823

Query: 887  IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
            I+ +   +KR  EN Q  +K+                    K Q+ N E+L  +++ QEE
Sbjct: 824  IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 862

Query: 947  IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
            +    AE+K   +    ++             E+ ++K     KE   LK+ L+  +Q  
Sbjct: 863  L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 904

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
            S S    K+  Q+ + L++++  LQ  L +      + + + + H +     +  +++ K
Sbjct: 905  SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 964

Query: 1058 QLKDLSQKYTEVKNVKEK 1075
             LK   Q  T  KN  +K
Sbjct: 965  VLK---QILTMCKNQSQK 979



 Score =  232 bits (591), Expect = 2e-60
 Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)

Query: 644  HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
            H   LSE   I+ L     +  A L    KP++H+QV     ++SG   K+      I+ 
Sbjct: 223  HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
              L + +  + I    L  K   E         K     ++ ++D         D L   
Sbjct: 283  TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336

Query: 755  LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
             LD++ +  ++ L      ++  L L N  L     +L+       + +    +  S   
Sbjct: 337  -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392

Query: 809  ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
            +L   L +  +    D +      IH+L    T+       L++++ +    +++ E  +
Sbjct: 393  DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 857  MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
              L   L     EL+     ++ +   D++Q+  + + K E   + + + Q Q+K   +S
Sbjct: 453  KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512

Query: 912  LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
                      HE +++    ++ K    NA  L    + +E++  L  E K  ++E  T+
Sbjct: 513  PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
             +       P+  +EE +  + +  + +  + +   +KY  ++EE+ K K   D LK ++
Sbjct: 569  IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
                 D         ++ +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++
Sbjct: 620  TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
             E +  + + + +H  L Q+  + ++        ++ L  M+  Y K    +T+L QL++
Sbjct: 668  LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
             QK +SV + EHLQ+          ++  +   +E   +K  EV+KL+ ++   K A+  
Sbjct: 722  AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779

Query: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
              T  +V  S Y+  +S LE+++S L  KL    ++ E+V  EV+  + +    K EKE 
Sbjct: 780  --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837

Query: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
            +     S EQE+ +  ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+A
Sbjct: 838  IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897

Query: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
            LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG
Sbjct: 898  LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956

Query: 1382 HMDEDVQEALLQIIQM 1397
             MDEDVQ+ L QI+ M
Sbjct: 957  QMDEDVQKVLKQILTM 972


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score =  351 bits (900), Expect = 3e-96
 Identities = 297/1098 (27%), Positives = 517/1098 (47%), Gaps = 172/1098 (15%)

Query: 17   DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
            +WNK DDRL++A E GD EKV S+L KKG +  K D EG++ FH+  +KG++ECL  ++ 
Sbjct: 15   EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74

Query: 77   HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
            HGVD+T  DT G +ALHLAAK  H  C++KLLQ  CP E  D  G+TALH AA   C  +
Sbjct: 75   HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134

Query: 137  IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
            +Q+LC+H + +N KD+DG  PL+LA Q     IC  L+D GADVNSR+K  RTALML CE
Sbjct: 135  VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194

Query: 197  YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL----------------- 239
             G  +AVE LIK GAD++L+D+LG+++ +Y+++ +N  I +LL                 
Sbjct: 195  IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPK 254

Query: 240  ------KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDL 293
                  K +SE +   ++     P +    L+ +    ++ S     +  + +       
Sbjct: 255  QHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK--ESVFFAEPPF 312

Query: 294  KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESL 350
            K  +  I++ +  L D   G       + ++    E++++ L SLL AK      H + L
Sbjct: 313  KAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLTLHNKEL 366

Query: 351  RTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRS 408
            +     K+  K  E+D L   S+ S + +    L K G+    DS+ +SP +  H     
Sbjct: 367  QDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH----- 418

Query: 409  MLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAL 466
                   SL   T+ ++  I  L++ L+ ++   ES++ +R +LQ EL  + AE   + L
Sbjct: 419  -------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCL 469

Query: 467  ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
                + E+S +    L   LK+ Q +  E+  +V  +Q     +K  L S  +  N+   
Sbjct: 470  NNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHF 522

Query: 527  EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
             EL+   +++ V                          K+D    +EE+           
Sbjct: 523  HELRVTEEEINV-------------------------LKQDLQNALEES----------- 546

Query: 587  MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEK 646
               E+   KV E+E +  E      +  P E++E MKSS  + +    K+   +  ++++
Sbjct: 547  ---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 603

Query: 647  SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI 706
            +  EI +LK   + +K+++ Q    +E E +K  + +   EL K+++EL+   +  Q E+
Sbjct: 604  AQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL 659

Query: 707  EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKK 766
            E  Y   K L++    +T E    Y+        K  H+ ++   N          +E K
Sbjct: 660  ED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAEDALSEMK 703

Query: 767  LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQE 826
             +  K+L E   L + V   +   V   +H + I  L++   E+++++S LK+     + 
Sbjct: 704  SQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEV 763

Query: 827  KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK 886
            ++  L  +    K  M++  VP  ++E+++ +L   ++    +L +  K+ E ++ E V+
Sbjct: 764  EVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 823

Query: 887  IKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEE 946
            I+ +   +KR  EN Q  +K+                    K Q+ N E+L  +++ QEE
Sbjct: 824  IRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKFQQAQEE 862

Query: 947  IVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKY 1003
            +    AE+K   +    ++             E+ ++K     KE   LK+ L+  +Q  
Sbjct: 863  L----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALNSLSQ-L 904

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRKTDELNK 1057
            S S    K+  Q+ + L++++  LQ  L +      + + + + H +     +  +++ K
Sbjct: 905  SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQK 964

Query: 1058 QLKDLSQKYTEVKNVKEK 1075
             LK   Q  T  KN  +K
Sbjct: 965  VLK---QILTMCKNQSQK 979



 Score =  232 bits (591), Expect = 2e-60
 Identities = 206/796 (25%), Positives = 376/796 (47%), Gaps = 88/796 (11%)

Query: 644  HEKSLSE---IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK------ITE 694
            H   LSE   I+ L     +  A L    KP++H+QV     ++SG   K+      I+ 
Sbjct: 223  HYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISP 282

Query: 695  LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
              L + +  + I    L  K   E         K     ++ ++D         D L   
Sbjct: 283  TQLSDVSSPRSITSTPLSGK---ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--- 336

Query: 755  LLDVTQKYTEKKL------EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
             LD++ +  ++ L      ++  L L N  L     +L+       + +    +  S   
Sbjct: 337  -LDISSEADQQDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKEAEADLSFDSYHSTQT 392

Query: 809  ELKKQLSELKKKCGEDQEK-----IHALTSENTN-------LKKMMSNQYVPVKTHEEVK 856
            +L   L +  +    D +      IH+L    T+       L++++ +    +++ E  +
Sbjct: 393  DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 452

Query: 857  MTLNDTLAKTNRELL-----DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYIS 911
              L   L     EL+     ++ +   D++Q+  + + K E   + + + Q Q+K   +S
Sbjct: 453  KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 512

Query: 912  LAE-------HEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
                      HE +++    ++ K    NA  L    + +E++  L  E K  ++E  T+
Sbjct: 513  PESMDNYSHFHELRVTEEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTV 568

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
             +       P+  +EE +  + +  + +  + +   +KY  ++EE+ K K   D LK ++
Sbjct: 569  IK------PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQM 619

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
                 D         ++ +M+ A++R  DELNKQ+ +LSQ Y   K  + +L +   +++
Sbjct: 620  TQEASD---------EAEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKS 667

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
             E +  + + + +H  L Q+  + ++        ++ L  M+  Y K    +T+L QL++
Sbjct: 668  LEDVTAEYIHKAEHEKLMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVD 721

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
             QK +SV + EHLQ+          ++  +   +E   +K  EV+KL+ ++   K A+  
Sbjct: 722  AQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM-- 779

Query: 1205 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEL 1264
              T  +V  S Y+  +S LE+++S L  KL    ++ E+V  EV+  + +    K EKE 
Sbjct: 780  --TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 837

Query: 1265 LHF---SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQA 1321
            +     S EQE+ +  ++  ++   + E++R  + S+K  E KD KI E+  +V +LK+A
Sbjct: 838  IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEA 897

Query: 1322 LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQG 1381
            LN LSQL+Y++ + +KRQSQ ++ LQ QVK L+ QLA+  +QHQEVI++YR HLL A QG
Sbjct: 898  LNSLSQLSYSTSS-SKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQG 956

Query: 1382 HMDEDVQEALLQIIQM 1397
             MDEDVQ+ L QI+ M
Sbjct: 957  QMDEDVQKVLKQILTM 972


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score =  257 bits (656), Expect = 6e-68
 Identities = 265/1137 (23%), Positives = 495/1137 (43%), Gaps = 122/1137 (10%)

Query: 13   RHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLN 72
            R + DW K D+RL++A E  D  +V +++A+KG+ P KLD EG+S FH+   +G   CL 
Sbjct: 40   RQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLE 99

Query: 73   AILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMAD 132
             ++ HG ++ ++D AG NALHLAAKYGH  CL++LLQ +C  +  D  G TALH AA   
Sbjct: 100  VMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGG 159

Query: 133  CPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM 192
            C S  ++LC   A +N +D  G TPL++A QM    +C+LL+ +GA  N +D Q RTALM
Sbjct: 160  CLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALM 219

Query: 193  LGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGREL 252
            L CE    + VEVL++ GA   + DALG D+++Y  +  +  IL LL+ A++  +    L
Sbjct: 220  LACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSAL 279

Query: 253  WK--KGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDK 310
             +   G +  Q +++    +   K  +           ++ D  E + +++QE+  LL K
Sbjct: 280  TEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQK 339

Query: 311  VNGLQ------LQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFE 364
            + GL+       Q + E      LE + ++L+ LL  ++++ E   R +E+L++R    E
Sbjct: 340  IRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLE 399

Query: 365  SDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIP-AHMQSRSMLRPLE----LSLPS 419
            ++         N   D+   Q      D +   P +P A +     L P       SL  
Sbjct: 400  NER-------ENTSYDVTTLQ------DEEGELPDLPGAEVLLSRQLSPSAQEHLASLQE 446

Query: 420  QTSY--SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE 477
            Q +    +N+ L ++++ +  F    ++D  +++ E    +AE   LAL  + ++ + D+
Sbjct: 447  QVAVLTRQNQELMEKVQILENF----EKDETQMEVE---ALAEVIPLAL-YDSLRAEFDQ 498

Query: 478  QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK 537
              +Q  +AL+            ++Q +T  +  +E     AA G   +            
Sbjct: 499  LRRQHAEALQ-----------ALRQQETREVPREE----GAACGESEVA----------- 532

Query: 538  VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 597
                GA+A        ++ N  +  E K +  + I+E     + +    ME E  G + T
Sbjct: 533  ----GATATKNG-PTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEAT 587

Query: 598  EMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE 657
                 A+   AK+  + P             EV E   +  E E   E   +  +    E
Sbjct: 588  ----GAEATGAKVTETKPT----------GAEVRE--METTEEEANMETKPTGAQATDTE 631

Query: 658  LENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE-------IEKVY 710
               V+A   +  K +  E         +G+    +T  T    T  +        +    
Sbjct: 632  TTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATG 691

Query: 711  LDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 770
            ++N  ++     ++     H    + SE ++   +  I  L   L    Q+  E   E+E
Sbjct: 692  VENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEAL---RQREREAAAELE 748

Query: 771  KLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHA 830
              L + ++   +  RL    V   +          +  +L+  L + ++   +   ++  
Sbjct: 749  AALGKCEAAEAEAGRLRE-RVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRE 807

Query: 831  LTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDK 890
            L + +  L +  +++ +     EE    L   LA+     L+  ++ E + ++    +  
Sbjct: 808  LEAASACLDEARASRLLA----EEEARGLRAELAQREEARLEQSRELEVLREQLATARAT 863

Query: 891  NEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI------LANYRKGQ 944
             E  +           A    +AE  A      Q + ++++++  +       + +R+ Q
Sbjct: 864  GEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQ 923

Query: 945  EEIV-------TLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER---KFKATEKELKD 994
            EE +       +L  E+ A  KE   ++  ++ +    V+  E ER     +A   +L+ 
Sbjct: 924  EEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEG 983

Query: 995  QLSEQTQKYSVSEEEVKK-------NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA 1047
            QL E  +++  +  EV +        K E    + ++ T ++ LR      E++ + +  
Sbjct: 984  QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSR 1043

Query: 1048 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK-QTSEILAVQNLLQKQHVPLEQ 1103
                 D+  ++ K +++   EV N+KE L E+ A   T E+ A+++ ++     L++
Sbjct: 1044 AQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQE 1100



 Score =  128 bits (321), Expect = 4e-29
 Identities = 98/387 (25%), Positives = 183/387 (47%), Gaps = 32/387 (8%)

Query: 1016 ENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
            +  +L+  +   ++DLRD+     +  E+E A S   DE         ++   ++    +
Sbjct: 783  DTTQLRAALEQAREDLRDRD---SRLRELEAA-SACLDEARASRLLAEEEARGLRAELAQ 838

Query: 1076 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1135
              E   +Q+ E+  ++  L       EQ       L    +  +  +  +    E+ +Q 
Sbjct: 839  REEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQG 898

Query: 1136 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1195
            + +L +  E  + S VP +EH +++E    E   ++      E+E     +E ++L++E+
Sbjct: 899  LAELREASEALRQSVVPASEHRRLQE----EALELRGRAASLEQEVVATGKEAARLRAEL 954

Query: 1196 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1255
            +  +           V LS+++     L+  ++ L  +L  L R++E+   EV   +++ 
Sbjct: 955  ERERVCS--------VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREA 1006

Query: 1256 ISAKDEKELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1312
            +  K E+      +   EQ+++  +   +++     + Q R QE+  + + KD KITEL 
Sbjct: 1007 LFMKSERHAAEAQLATAEQQLRGLRTEAERA----RQAQSRAQEALDKAKEKDKKITELS 1062

Query: 1313 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
             +V  LK+AL            P    +  ++ L+ QVK L+QQL +A R H  V+A+YR
Sbjct: 1063 KEVFNLKEALKE---------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYR 1113

Query: 1373 THLLSAAQGHMDEDVQEALLQIIQMRQ 1399
            +HLL A QG MDEDVQ  L QI+QM++
Sbjct: 1114 SHLLYAIQGQMDEDVQRILSQILQMQR 1140



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 54/225 (24%), Positives = 106/225 (47%), Gaps = 24/225 (10%)

Query: 1118 LKEELKSMQRCYEKEQQT---VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1174
            L ++++ +++  E+ QQ     + LH L    +     L E  + KE+  +EV  +++ L
Sbjct: 336  LLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRL 395

Query: 1175 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1234
               E E +N   +V+ LQ E    +  L  L   EV+ LS+  +  +  +  ++SL E++
Sbjct: 396  SLLENERENTSYDVTTLQDE----EGELPDLPGAEVL-LSRQLSPSA--QEHLASLQEQV 448

Query: 1235 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1294
            A L R+ +E+ E+V   +  E   KDE ++   ++ + I       D       +L+R+ 
Sbjct: 449  AVLTRQNQELMEKVQILENFE---KDETQMEVEALAEVI--PLALYDSLRAEFDQLRRQH 503

Query: 1295 QESAKQIEAKDNKITELLNDVERLKQALNGLSQL---TYTSGNPT 1336
             E+ + +  ++ +      +V R + A  G S++   T T   PT
Sbjct: 504  AEALQALRQQETR------EVPREEGAACGESEVAGATATKNGPT 542



 Score = 38.1 bits (87), Expect = 0.060
 Identities = 70/339 (20%), Positives = 127/339 (37%), Gaps = 72/339 (21%)

Query: 286  LEIENEDLKERLRKIQQEQRI--LLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 343
            LE   EDL++R  ++++ +     LD+    +L   EE             L++ LA +E
Sbjct: 791  LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEA----------RGLRAELAQRE 840

Query: 344  KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 403
            +   E  R +E L+        + L +      ++     + G+   A     +    A 
Sbjct: 841  EARLEQSRELEVLR--------EQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC 892

Query: 404  MQSRSMLRPL----ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVA 459
             ++R  L  L    E    S    SE+  L++E   +R    S +Q+ +    E A   A
Sbjct: 893  EEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRA 952

Query: 460  E------CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK-- 511
            E      C     E ER+       + QLE  L+++ +R  ++  +V Q+Q   L +K  
Sbjct: 953  ELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSE 1012

Query: 512  --------------------------------EHLTSEAASGNHRLTE------ELKDQL 533
                                            +    +A   + ++TE       LK+ L
Sbjct: 1013 RHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEAL 1072

Query: 534  KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 572
            K+       A+ EV  LR+Q+K  +  ++E  RD   ++
Sbjct: 1073 KEQPAAL--ATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109



 Score = 32.7 bits (73), Expect = 2.5
 Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 17/175 (9%)

Query: 1223 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDK 1282
            L  +   L +K+  L +  E   +E   A    I  +  +EL    +E++  ++KE    
Sbjct: 329  LRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQ--EEKE---- 382

Query: 1283 SLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL 1342
                   L R ++    ++   +N+      DV  L+     L  L    G       QL
Sbjct: 383  ------SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLP---GAEVLLSRQL 433

Query: 1343 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1397
              + Q  + SL++Q+A   RQ+QE++   +  +L   +    +   EAL ++I +
Sbjct: 434  SPSAQEHLASLQEQVAVLTRQNQELME--KVQILENFEKDETQMEVEALAEVIPL 486


>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
          Length = 1001

 Score =  197 bits (500), Expect = 8e-50
 Identities = 115/345 (33%), Positives = 183/345 (53%), Gaps = 10/345 (2%)

Query: 6   FSCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSK 65
           FSC+        WN++D +L++A  RGDV +V ++ ++K   P KLD  G+S FH+  SK
Sbjct: 5   FSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASK 64

Query: 66  GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTAL 125
           G  ECL  +L +G DI + +  G  ALHLA       C++ LLQ+    +  D + R+ L
Sbjct: 65  GLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPL 124

Query: 126 HDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDK 185
           H AA + C SS+ LLCDH A ++  D DGRTPL++A+      IC  L+ RGA VN  DK
Sbjct: 125 HWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184

Query: 186 QNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASEN 245
            +++AL+L CE G  +  E+L+ +GAD   +D+ GHD+ +YA    +  +   L+ A   
Sbjct: 185 NDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSR 244

Query: 246 TNKGRELWKKGPSL-QQRNLTHMQDEVNVKSHQREHQNIQDLEIENED---------LKE 295
             +G +   + P L  Q + +  Q     KS  R     +  E E+ED          +E
Sbjct: 245 RRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEE 304

Query: 296 RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 340
             RK+ + ++ L+ K    + Q    + + + +  + ++L  LL+
Sbjct: 305 ERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLS 349



 Score =  110 bits (275), Expect = 9e-24
 Identities = 95/420 (22%), Positives = 189/420 (45%), Gaps = 42/420 (10%)

Query: 993  KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT 1052
            K QL ++     +S   +    +E  +L +E   LQ++L+  +  +++    +     + 
Sbjct: 610  KGQLEKEMSVLRLSNSNLL---EELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQL 666

Query: 1053 DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL--------QKQHVPLEQV 1104
             +L + +  L+ +    K   EKL +  A Q+S +  + + L          Q    E +
Sbjct: 667  QQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESL 726

Query: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1164
            E L+  ++  ++  +E  + + R  E+ QQ    L    E   +   P +  +    A E
Sbjct: 727  EELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVA---ALE 783

Query: 1165 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
            +++G ++  LR  +     K +E+ KL+  +    + + +L  RE   L +++ T+  L 
Sbjct: 784  QDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLV 843

Query: 1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQE--IKDQKER 1279
             Q  +  ++L  L  KY   C EV   + +E  A++ +   +L   + EQE    + + R
Sbjct: 844  AQAQAWGQELKALLEKYNTACREV--GRLREAVAEERRRSGDLAAQAAEQERQASEMRGR 901

Query: 1280 CDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQ 1339
             ++   T   L+ +++        K+ KI ELL  +E+L                     
Sbjct: 902  SEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL--------------------- 940

Query: 1340 SQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQ 1399
            S+ +  ++ +   L  QL D+ + H+E+I+ YR HLL+AA+G+M+ +V   LLQI+ M +
Sbjct: 941  SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEE 1000



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 74/375 (19%), Positives = 156/375 (41%), Gaps = 58/375 (15%)

Query: 414  ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAECKALALECER 470
            EL++  + +    ++L  +   +R   +    D +     Q++ A  + E +A    C  
Sbjct: 679  ELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRA----CIS 734

Query: 471  VKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELK 530
               D   + +Q+   L  +Q+   +  G +   +    +LK   + + A+    L + L+
Sbjct: 735  TLVDRHREAQQV---LARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGK-LE 790

Query: 531  DQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 590
            ++L+ ++    G S E+GKL+  + Q    V E +  E   + ++++             
Sbjct: 791  EELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEK------------- 837

Query: 591  KKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 650
             +G  V + +   +EL A L      EK+    ++   EV    + + E  R      ++
Sbjct: 838  TRGSLVAQAQAWGQELKALL------EKY----NTACREVGRLREAVAEERRRSGDLAAQ 887

Query: 651  IRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG---ELGKKITELTLKNQTLQKEIE 707
              + +R+   ++ +  Q  K    E +K ++E   G   +   KI EL  K + L +E+ 
Sbjct: 888  AAEQERQASEMRGRSEQFEKTA--ELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEV- 944

Query: 708  KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL 767
                           L I  +N  + L++ +D +K+H+ II      LL+  + Y E   
Sbjct: 945  ---------------LAIRGENARLALQL-QDSQKNHEEIISTYRNHLLNAARGYMEH-- 986

Query: 768  EMEKLLLENDSLSKD 782
            E+  +LL+  S+ ++
Sbjct: 987  EVYNILLQILSMEEE 1001



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 70/355 (19%), Positives = 159/355 (44%), Gaps = 54/355 (15%)

Query: 768  EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 827
            E ++L  E  SLS+   RL+  FVP  + + ++  L+ ++  L  +L+ ++K+  E   K
Sbjct: 637  ERQRLQRELQSLSQ---RLQREFVPKPEAQVQLQQLRQSVGLLTNELA-MEKEATEKLRK 692

Query: 828  IHALTSENTNLKKMM-----------SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKK 876
            +  L S+++ L+ +            S Q    ++ EE++  ++ TL   +RE   V  +
Sbjct: 693  L--LASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACIS-TLVDRHREAQQVLAR 749

Query: 877  FEDINQEF-------------VKIKDKNEI--LKRNLENTQNQIKAEYISLAEHEAKMSS 921
             ++ NQ+              +K     ++  L+++L   + +++A   +++    ++  
Sbjct: 750  LQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGK 809

Query: 922  LSQSMRKVQDSNAEI----LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 977
            L Q + +  +  AE+     A+ R+ ++   +L A+ +A  +EL  + E        +  
Sbjct: 810  LKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGR 869

Query: 978  FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1037
              E   + +    +L  Q +EQ ++ S      ++ ++  + LK+++  L    RDK   
Sbjct: 870  LREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDK--- 926

Query: 1038 IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL---VEENAKQTSEILA 1089
                         K  EL K+L+ LS++   ++    +L   ++++ K   EI++
Sbjct: 927  -----------EAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIIS 970


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  182 bits (462), Expect = 2e-45
 Identities = 270/1176 (22%), Positives = 503/1176 (42%), Gaps = 199/1176 (16%)

Query: 285  DLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN-------EEVMVADDLESEREKLKS 337
            D++ E EDL      + +EQ  L+ ++  ++  L+       E V     L+ E++KL+ 
Sbjct: 119  DMDSEAEDLVGNSDSLNKEQ--LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG 176

Query: 338  LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTS 397
            +L+  +   ++SLR I  L+   +  +         F     D  L++   Y++  Q   
Sbjct: 177  ILSQSQ---DKSLRRIAELREELQMDQQAKKHLQEEF-----DASLEEKDQYISVLQTQV 228

Query: 398  PGIPAHMQSRSM----LRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNE 453
              +   +++  M    L+PL    P      + E+  KE        E+ + D       
Sbjct: 229  SLLKQRLRNGPMNVDVLKPLPQLEP------QAEVFTKE--------ENPESDG------ 268

Query: 454  LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 513
                           E V ED    +K LE     +Q+R+   E  +K+ +    + KE 
Sbjct: 269  ---------------EPVVEDGTS-VKTLET----LQQRVKRQENLLKRCKETIQSHKEQ 308

Query: 514  LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 573
             T    S    L E+L ++L++L+   +   AE  KL  Q++  + ++E+ ++D+G +I 
Sbjct: 309  CTL-LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA 367

Query: 574  ENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN-EVN 631
            E KR   E L M E E  +   ++ +M  Q +EL  +   S  A  FE ++ +LS  +  
Sbjct: 368  ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA-FEELEKALSTAQKT 426

Query: 632  EKAKKLVEMEREH-----EKSLSEIR-QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 685
            E+A++ ++ E +      EK+  E R  L++EL  VK ++   +K    EQ+    +   
Sbjct: 427  EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486

Query: 686  GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 745
             EL +K  ELT K QT ++E ++  +   L K Q+  L I  +         E+++    
Sbjct: 487  KELARKEQELTKKLQTREREFQE-QMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545

Query: 746  AIIDDLNRKLLDVTQK---YTEKKLEME----KLLLENDSLSKDVS-RLETVFVPPEKHE 797
            AI+ +   KL D+ Q+   Y  + LE+E    K L EN + SKD++  LE       KH 
Sbjct: 546  AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEA---EKNKHN 602

Query: 798  KEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKM 857
            KEI  +   + + K +L  LK          H   +  T   +++  QY           
Sbjct: 603  KEITVM---VEKHKTELESLK----------HQQDALWTEKLQVLKQQY----------- 638

Query: 858  TLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA 917
                       E+  +++K E   +    +KDK  I + ++E   N+   E + + + E 
Sbjct: 639  ---------QTEMEKLREKCEQEKETL--LKDKEIIFQAHIEE-MNEKTLEKLDVKQTE- 685

Query: 918  KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 977
             + SLS  +       +E+L    K +EE+  L  +    K+EL+   +  K  +   V 
Sbjct: 686  -LESLSSEL-------SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD 737

Query: 978  --FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT 1035
               +E E   + TEK LKDQ+++        ++ +K+++   + L+ +I   + +L+  +
Sbjct: 738  SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS 797

Query: 1036 VLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK---EKLVEENAKQTSEI----- 1087
              ++     + A   +T    +QL  L QK  +++  +    K V E   Q  ++     
Sbjct: 798  AKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD 857

Query: 1088 ---LAVQNLLQKQHVPLEQVEALKKSLNGTIENL-----KEELKSMQRCYEKEQQTVTKL 1139
               + VQ+L+Q+      ++E   KSL    E+      KE+ ++ Q   EKE   +   
Sbjct: 858  AHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL--- 914

Query: 1140 HQLLENQKNSSVPLAEHLQIKEAF---------------EKEVGIIKASLREKEEESQNK 1184
             Q+ E QK     L + L  KE                 EK++  +K   +E +E  + K
Sbjct: 915  -QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973

Query: 1185 -MEEVSKLQSEVQNT--------------------------KQALKKLETREVVDL-SKY 1216
             +++ +KL+ E++NT                            A+ +LET +   + S  
Sbjct: 974  LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033

Query: 1217 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1276
            +  + +L   IS   +KL     + +E+ E  L  K++E++   +K LL    ++E+  +
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093

Query: 1277 ----KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN-GLSQLTYT 1331
                KE   K  TT+ ELQ ++++ +  + +     T+L   +E+L+  LN  L + T+ 
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153

Query: 1332 SGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
                 + +  L +  + +V  L  +L   D + Q +
Sbjct: 1154 QEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSL 1188



 Score =  171 bits (433), Expect = 5e-42
 Identities = 248/1170 (21%), Positives = 515/1170 (44%), Gaps = 154/1170 (13%)

Query: 269  DEVNVKSHQREHQNIQDLEIENEDLKERLR---KIQQEQRILLDKVNGLQLQLNEEVMVA 325
            +E+N K+ ++      +LE  + +L E L+   K+++E  +L D+ + ++ +L  E  + 
Sbjct: 669  EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL--EAKMD 726

Query: 326  DDLESEREKLKSLLAAKEKQHEESL-RTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLK 384
            +     ++++ S++    K+HE S+ RT +ALK++    E            ++ D  LK
Sbjct: 727  EQKNHHQQQVDSII----KEHEVSIQRTEKALKDQINQLE---------LLLKERDKHLK 773

Query: 385  QGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAK 444
            + Q ++ + +         +Q  S    +  S  S T + + +  +++L  ++      +
Sbjct: 774  EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT-HEQTKAYEEQLAQLQQKLLDLE 832

Query: 445  QDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM------YES-- 496
             +R+ L  ++A   A+ K +  E +  K    + ++QLE    ++++++      YES  
Sbjct: 833  TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL 892

Query: 497  -EGKVKQMQT-HFLALKEHLTSEAASGNHR----LTEEL---KDQLKDLKVKYEGASAEV 547
             +G  +Q QT   L  KE++  +   G  +    LT++L   +D +  L  +YE      
Sbjct: 893  EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952

Query: 548  GKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS 607
             K   ++KQ    ++E  +   KL+++  +L+KEL    +E  +K           K+ +
Sbjct: 953  EKKMEKVKQKAKEMQETLKK--KLLDQEAKLKKELENTALELSQK----------EKQFN 1000

Query: 608  AKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV----KA 663
            AK+           M  + S  +++   +L   ++E  +SL+E+   +REL +V    + 
Sbjct: 1001 AKML---------EMAQANSAGISDAVSRLETNQKEQIESLTEVH--RRELNDVISIWEK 1049

Query: 664  KLAQHVKP--EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAH 721
            KL Q  +   E HE      EQ+  EL +KI     + + + KEI   +L  + +K+   
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI--TWLKEEGVKQDT- 1106

Query: 722  NLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSK 781
                        L   ++  K   A ++ L        Q  T+ K  +EKL ++   L+K
Sbjct: 1107 -----------TLNELQEQLKQKSAHVNSL-------AQDETKLKAHLEKLEVD---LNK 1145

Query: 782  DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 841
             +   E  F+     +++++ LK    E K+++SEL  K     E+  +L S +    K 
Sbjct: 1146 SLK--ENTFL-----QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198

Query: 842  MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 901
            + ++ +  K   E      D   K    LL+ K   E IN   +     N IL R + + 
Sbjct: 1199 LEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN-ELIN---ISSSKTNAILSR-ISHC 1253

Query: 902  QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 961
            Q++      +L      +S L   +R++ +    +  ++++   ++     +IK+ K ++
Sbjct: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADI 1313

Query: 962  DTIQECIKVKYAPIVSFEECERKFKATEKE-----LKDQLSEQTQKYSVSEEEVKKNKQE 1016
            +++     V     +  E   ++  A+EKE     LK +LSE     ++ +EE+K+ K E
Sbjct: 1314 ESL-----VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368

Query: 1017 NDKLKKEIFTLQKDLRDKTVLIE---------KSHEMERA--------LSRKTDELNK-- 1057
               L K++  L   L++   L E         K ++ E+         LS K D L+K  
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428

Query: 1058 -----QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ-HVPLEQVEALKKSL 1111
                 Q+ D S K++E K   +    ++     E+     L  K+ +   EQ+  LK+ L
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488

Query: 1112 ---NGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE-AFEKEV 1167
               N   + LK E++  +   EK++   + L   L++Q    + L +H+  K    E   
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKE---SNLETELKSQTARIMELEDHITQKTIEIESLN 1545

Query: 1168 GIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQI 1227
             ++K   ++K+ E +  ++++   Q   +     +K+ E + +   ++  + K++LET+ 
Sbjct: 1546 EVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605

Query: 1228 SSLNEKLANLNRKYEEV------CEEVLHAKKKEISAKDEKEL--LHFSIEQEIKDQKER 1279
              L     ++  K EE+       E    AK  E+  K E+++  +   +  ++++++E+
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665

Query: 1280 CDKSLTT-ITELQRRIQESAKQIEAKDNKITEL-LNDVERLKQALNGLSQLTYTSGNPTK 1337
              K   + ++EL  ++QE  +++   + K+  +  +  E L    +  +   YT      
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725

Query: 1338 RQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
             Q  +  T + ++  L++ L + ++  Q V
Sbjct: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755



 Score =  167 bits (422), Expect = 9e-41
 Identities = 256/1165 (21%), Positives = 497/1165 (42%), Gaps = 150/1165 (12%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 295
            + L     E  NK     K+    Q   L  +Q+++  KS      ++  L  +   LK 
Sbjct: 1080 ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS-----AHVNSLAQDETKLKA 1134

Query: 296  RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ-------HEE 348
             L K++ +    L +   LQ QL E  M+A++ + +  +L S L   +++       HE+
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194

Query: 349  SLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLL--KQGQMYMADSQCTSPGIP--AHM 404
            S +++E     FK   S+ L        +K + LL  K  ++    S  T+  +   +H 
Sbjct: 1195 SNKSLEDKSLEFKKL-SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253

Query: 405  QSRSMLRPLELSLPSQTSYSENEILKKEL-EAMRTFCESAKQDRLKLQ---NELAHKVAE 460
            Q R+  +  E  L    + SE E   ++L E   T   S +Q   +L+   N++    A+
Sbjct: 1254 QHRTT-KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312

Query: 461  CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 520
             ++L  E E ++++   Q           Q+   E E  + Q       LK+ L     S
Sbjct: 1313 IESLVTEKEALQKEGGNQ-----------QQAASEKESCITQ-------LKKEL-----S 1349

Query: 521  GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK 580
             N      +K++LK+ KV+    S ++  L  Q+ QN + + E +     L     R Q 
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSL-----RKQY 1403

Query: 581  ELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 640
            +   CE+  + +           +++SA   +   + KF   K    +   +    + E+
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463

Query: 641  EREHEKSLSEIRQLKRELENVKAKLAQHVK-----PEEHEQVKSRLEQKSGELGKKITEL 695
            + + E    E  +   ++  +K +L Q  K       E E  KS++E+K   L  ++   
Sbjct: 1464 QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523

Query: 696  TLKNQTLQKEIEKVYLD----NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 751
            T +   L+  I +  ++    N++LK       IE K     L+  +++ +  D  + + 
Sbjct: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEA 1583

Query: 752  NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV-EL 810
              K+L +  +    K E+E    E          LE V +  +  E+E+ AL+  +  E 
Sbjct: 1584 EEKILTLENQVYSMKAELETKKKE----------LEHVNLSVKSKEEELKALEDRLESES 1633

Query: 811  KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 870
              +L+ELK+K    ++KI A+  +  +  +    QY   K  E     LN  L +  RE+
Sbjct: 1634 AAKLAELKRKA---EQKIAAIKKQLLSQMEEKEEQYK--KGTESHLSELNTKLQEREREV 1688

Query: 871  LDVKKKFEDINQEFVKIKDKNEILKRNLENT-----QNQIKAEYISLAEHEAKMSSLSQS 925
              +++K + +       + +  I+ R+ +N      Q +  ++      +E K+S L ++
Sbjct: 1689 HILEEKLKSVESS----QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN 1744

Query: 926  MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 985
            + + +    ++L    + +EE V+ H E++ Q +E       IK+++A     E+     
Sbjct: 1745 LTEKE----KLLQRVGQEKEETVSSHFEMRCQYQE-----RLIKLEHAEAKQHED----- 1790

Query: 986  KATEKELKDQLSEQTQKYS------VSEEEVKKNKQENDKLKKEIFTLQKDLRDKT---- 1035
            ++    L+++L E+ +KYS      V +E  K N Q    L+     +QK L++K     
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850

Query: 1036 VLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV--------KNVKEKLVEENAKQTSEI 1087
            +L +K  E++  L R+ +    ++++L+ KY ++        +N   +L+EEN ++ S+ 
Sbjct: 1851 ILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910

Query: 1088 LAVQNLL----QKQHVPLE----QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
              VQ  L    + QH  LE      E  K+ L   I  L+++L+ +++ +++E + + K 
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970

Query: 1140 HQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTK 1199
            +     +K       E L++K         +K  +RE   +   K +E+          K
Sbjct: 1971 YDQEREEKIKQEQ--EDLELKHN-----STLKQLMREFNTQLAQKEQELE------MTIK 2017

Query: 1200 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAK 1259
            + + K +  E   L  ++   + L  +I+  ++ L    ++Y    EE+L A+++E++AK
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY----EEILDAREEEMTAK 2073

Query: 1260 -----DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1314
                  + E L    +Q++ +Q+E       TI ELQ ++ +    I     K  E    
Sbjct: 2074 VRDLQTQLEELQKKYQQKL-EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132

Query: 1315 VERLKQALNGLSQLTY--TSGNPTK 1337
            +  L+  L    +  Y  T G P K
Sbjct: 2133 IHNLEDRLKKYEKNVYATTVGTPYK 2157



 Score =  162 bits (409), Expect = 3e-39
 Identities = 275/1365 (20%), Positives = 559/1365 (40%), Gaps = 254/1365 (18%)

Query: 240  KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNI---QDLEIENEDLKER 296
            + A E   K     +K    +++    M +++       E + I   Q+L    +++ + 
Sbjct: 410  RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469

Query: 297  LRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 356
            ++K  +EQ   L K++  +L   E+ +       ERE  + +  A EK   E L+  +  
Sbjct: 470  MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529

Query: 357  KNR----FKYFESDHLGSGSHFSNRKEDMLLKQGQMY--------------MADSQCTSP 398
            + +     +  E       +   N+  D L ++ + Y              + +++  S 
Sbjct: 530  EQQESLALEELELQKKAILTESENKLRD-LQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 399  GIPAHMQSRSMLRPLELSLPSQTSYSENEILK-------------------KELEAMRTF 439
             +  H+++       E+++  +   +E E LK                    E+E +R  
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 440  CESAKQDRL----------------KLQNELAHKVAECKALALECERVKEDSDEQIKQLE 483
            CE  K+  L                K   +L  K  E ++L+ E   V +   +  ++L 
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 484  DALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQ----------- 532
                   K   E E K+ + + H     + +  E      R  + LKDQ           
Sbjct: 709  VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 533  ---LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK-------RLQKEL 582
               LK+ +   E   A++ +   +++Q    ++ F+  +    E+ K       +LQ++L
Sbjct: 769  DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828

Query: 583  SMCEMEREKKGRKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEME 641
               E ER    ++V E+E Q K++  +L A  I  +         ++E+ +K K L ++ 
Sbjct: 829  LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888

Query: 642  R------------------EHEKSLSEIRQ-LKRELENVKAKLAQ-----HVKPEEHEQV 677
                               E E  + ++R+  K+E+E +  KL+      H+  EE+E  
Sbjct: 889  ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948

Query: 678  KSRLEQKSGELGKKITEL--TLKNQ------TLQKEIEKVYLDNKLLKEQAHNLTIEMKN 729
                E+K  ++ +K  E+  TLK +       L+KE+E   L+    ++Q +   +EM  
Sbjct: 949  FKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQ 1008

Query: 730  ------HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN------D 777
                       ++  + K+  +++ +   R+L DV   + EKKL  +   L+        
Sbjct: 1009 ANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW-EKKLNQQAEELQEIHEIQLQ 1067

Query: 778  SLSKDVSRLETVFV----PPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTS 833
               ++V+ L+   +      E+  KEI  LK   V+    L+EL+++  +    +++L  
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127

Query: 834  ENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA-------KTNRELLDVKKKFEDINQEFVK 886
            + T LK  +    V +    +    L + L        +  R++ ++  K +  ++EF  
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187

Query: 887  IKDKNEILKRNLENTQNQIKAEYISLA--------EHEAKMSSLSQSMRKVQDSNAE-IL 937
            +K  +E   ++LE+   + K     LA        + EA + + +  +  +  S    IL
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247

Query: 938  ANYRKGQEEIVTLH----------AEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFK 986
            +     Q     +           +E++AQ ++L   Q  + + +       EE E + K
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307

Query: 987  ATEKELKDQLSEQ--TQKYSVSEEEVKKNKQE-NDKLKKEIFTLQKDLRDKTVLIEKSHE 1043
            + + +++  ++E+   QK   ++++    K+    +LKKE   L +++   T++ E+  E
Sbjct: 1308 SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE---LSENINAVTLMKEELKE 1364

Query: 1044 ME---RALSRKTDELNKQLKD---LSQKYTEVKNVKEKLVEENAKQTSEI----LAVQNL 1093
             +    +LS++  +LN QL++   LS+K   + +++++  EE  +   ++      V  L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424

Query: 1094 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153
             +++   LEQV+      +       E  K  Q  + + Q TV +L   LE         
Sbjct: 1425 SKEKISALEQVDDWSNKFS-------EWKKKAQSRFTQHQNTVKELQIQLE--------- 1468

Query: 1154 AEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1213
               L+ KEA+EK+  I   +L ++E + QNK  +   L+ E+++ K  ++K E+    +L
Sbjct: 1469 ---LKSKEAYEKDEQI---NLLKEELDQQNKRFDC--LKGEMEDDKSKMEKKESNLETEL 1520

Query: 1214 SKYKATKSDLE-------TQISSLNEKLANLNRK--------------YEEVCEE----- 1247
                A   +LE        +I SLNE L N N++              ++E+ EE     
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580

Query: 1248 ------------VLHAKKKEISAKDEKELLHFSI-----EQEIKDQKERCD-KSLTTITE 1289
                         +++ K E+  K +KEL H ++     E+E+K  ++R + +S   + E
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETK-KKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639

Query: 1290 LQRRIQESAKQIEAKDNKITELLNDVERLKQALNG-LSQLTYTSGNPTKRQSQLIDTLQH 1348
            L+R+ ++    I  K   ++++    E+ K+     LS+L       TK Q +     + 
Sbjct: 1640 LKRKAEQKIAAI--KKQLLSQMEEKEEQYKKGTESHLSELN------TKLQER-----ER 1686

Query: 1349 QVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQ 1393
            +V  LE++L   +    E + + R+    AA    +E   +  +Q
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  181 bits (460), Expect = 3e-45
 Identities = 251/1181 (21%), Positives = 513/1181 (43%), Gaps = 189/1181 (16%)

Query: 268  QDEVNVKSHQREHQNIQDLEIEN--EDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVA 325
            Q E + K H+ E   + +L+ EN  +  +   + IQ++    L+ +       N++  + 
Sbjct: 258  QIEASAKEHEAEINKLNELK-ENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC 316

Query: 326  DDLESEREKLKSLLAAKEKQHEESLRTIEA----LKNRFKYF-------ESDHLGSGSHF 374
              L  E   ++ ++  K K  E++L+ +E+    LK+   Y        E D       F
Sbjct: 317  SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376

Query: 375  SNRKEDMLLKQGQMYMADSQ--CTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE 432
             + +ED+  K  ++ +A  +  C    + + +   +      +   ++   S  E  +KE
Sbjct: 377  FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436

Query: 433  L-EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQI---KQLEDALKD 488
            + E   TF   +++++L L  E+       + L  +CE ++++  E I   + L + ++ 
Sbjct: 437  ISELNETFLSDSEKEKLTLMFEI-------QGLKEQCENLQQEKQEAILNYESLREIMEI 489

Query: 489  VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVG 548
            +Q  + ES GK+ Q    F ++K+    + AS  H L +                     
Sbjct: 490  LQTELGESAGKISQ---EFESMKQ----QQASDVHELQQ--------------------- 521

Query: 549  KLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSA 608
            KLR    + + ++E   R +G    EN++L   LS  E+        V E+E   K L  
Sbjct: 522  KLRTAFTEKDALLETVNRLQG----ENEKL---LSQQEL--------VPELENTIKNLQE 566

Query: 609  K-----LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 663
            K     L+LS      + ++  +++   EK   + +++  HE+  +  ++ +RE E +  
Sbjct: 567  KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE-ERLIL 625

Query: 664  KLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 723
            +L + V  E+  Q  S LEQK  EL   + E   +     +++EK+ +  K+L E    L
Sbjct: 626  ELGKKV--EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683

Query: 724  TIEMKNHYVPL-KVSEDMKK-SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSK 781
            + E+K+ Y    K+S + K+ S D  +    ++ + + +  T+ + +++ ++ E D+L+K
Sbjct: 684  SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743

Query: 782  --DVSRLETVFVPPEKH---------------EKEIIALKSNIVELKKQLSELKKKCG-- 822
              +  +++ +FV  + +               EK+++ +   + E   +++E  +KC   
Sbjct: 744  LLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE--EKCNLA 801

Query: 823  -EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT---NRELLDVKKKFE 878
             +  EK+  L  E   +K +     V     EE+K  L D   +     +EL +++ + E
Sbjct: 802  FQRDEKVLELEKE---IKCLQEESVVQC---EELKSLLRDYEQEKVLLRKELEEIQSEKE 855

Query: 879  DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 938
             +  + +++K+ NE  K  LEN    I+ E +S    ++++ +  +     +  N + L 
Sbjct: 856  ALQSDLLEMKNANE--KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 939  NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSE 998
                 Q+E+    AE+   K   D++ +   VK  P+ S +E E K +  EKE K++   
Sbjct: 914  E----QKELRDRRAELILLK---DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK--- 963

Query: 999  QTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQ 1058
                    EE++ K K    K KKE+ + +K+ +  TV      E+E   S K D+L+  
Sbjct: 964  --------EEKINKIKLVAVKAKKELDSSRKETQ--TV----KEELESLRSEK-DQLSAS 1008

Query: 1059 LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENL 1118
            ++DL Q     KN    L+ E  KQ+ ++           V  E+    +  +      L
Sbjct: 1009 MRDLIQGAESYKN----LLLEYEKQSEQL----------DVEKERANNFEHRIEDLTRQL 1054

Query: 1119 KEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKE 1178
            +      +      +  + ++  L  N K   V + E  + K   +KE+   K    +K 
Sbjct: 1055 RNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI 1114

Query: 1179 EESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK--------SDLETQISSL 1230
            +E    + E+ +LQ ++Q  K+ L+K  T + ++L K  A +        +D E  +  L
Sbjct: 1115 KEHATTVNELEELQVQLQKEKKQLQK--TMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172

Query: 1231 NEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ-----------------EI 1273
            N+KL N N K E++ +E+   K+K+ + ++E   L  S++Q                 E+
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1232

Query: 1274 KDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
             D K+     L     L+  ++ S +Q+E    ++ E+ ++  ++ + L           
Sbjct: 1233 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK---------- 1282

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTH 1374
               ++  + +   Q +V +L+++   A  +   V + + ++
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESY 1323



 Score =  149 bits (377), Expect = 1e-35
 Identities = 244/1115 (21%), Positives = 471/1115 (42%), Gaps = 186/1115 (16%)

Query: 230  GDNLDILTLLKTASENTNKGRELWKKGP----SLQQRN--LTHMQDEVNVKSHQREHQNI 283
            G+N  +L+  +   E  N  + L +K      SL QR+  L  ++ ++N  + +++   I
Sbjct: 542  GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD-DFI 600

Query: 284  QDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 343
              L+  +E++    +K ++E+R++L+    L  ++ + +    +LE +  +L   L    
Sbjct: 601  NKLKNSHEEMDNFHKKCEREERLILE----LGKKVEQTIQYNSELEQKVNELTGGLEETL 656

Query: 344  KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 403
            K+ +++ + +E L  + K    D           KE +  +   +Y  +++ +S      
Sbjct: 657  KEKDQNDQKLEKLMVQMKVLSED-----------KEVLSAEVKSLYEENNKLSS------ 699

Query: 404  MQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESA--KQDRLK--LQNELAHKV- 458
             + + + R LE+ L    S  E+ ILK+ +  +    +    +QD L   L+NE   K+ 
Sbjct: 700  -EKKQLSRDLEVFL----SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLF 754

Query: 459  --AECKALALEC-ERVKEDSDEQ-----IKQLEDALKDVQKRM----YESEGKVKQMQTH 506
               +      E    V EDS+E+     ++ + ++L  + +      ++ + KV +++  
Sbjct: 755  VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKE 814

Query: 507  FLALKEHLTSEAASGNHRLTEELKDQLKD-------LKVKYEGASAEVGKLRNQIKQNEM 559
               L+E    +         EELK  L+D       L+ + E   +E   L++ + + + 
Sbjct: 815  IKCLQEESVVQC--------EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866

Query: 560  IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEG-----QAKELSAKLA--- 611
              E+ + +   L+ + + + +  S  E+  EK+   + E E      + KEL  + A   
Sbjct: 867  ANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI 926

Query: 612  -LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVK 670
             L     K  ++K+   + V E  +K+  +E+E ++   +I ++K  L  VKAK      
Sbjct: 927  LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK--LVAVKAKKELDSS 984

Query: 671  PEEHEQVKSRLEQKSGE---LGKKITEL-----TLKNQTLQKEIEKVYLDNKLLKEQAHN 722
             +E + VK  LE    E   L   + +L     + KN  L+ E +   LD +  KE+A+N
Sbjct: 985  RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE--KERANN 1042

Query: 723  -------LTIEMKNHYVPLKVSEDMKKSHDAIIDDL--NRKLLDV-------TQKYTEKK 766
                   LT +++N  +  +      +   A I+ L  N KLL+V        +   +K+
Sbjct: 1043 FEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102

Query: 767  LEMEKLLLEND--SLSKDVSRLETVFVPPEKHEKEI-----------------IALKSNI 807
            LE EKL  E      +  V+ LE + V  +K +K++                   +   I
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI 1162

Query: 808  VELKKQLSELKKKCGEDQEKIHALTSE-------NTNLKKMMSNQYVPVKTHEEVKMTLN 860
             + ++ + EL +K      KI  L  E          L++ +++    V+ +EE    + 
Sbjct: 1163 ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK 1222

Query: 861  DTLAKTNRELLDVKKKFED--INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 918
              L KT +EL D K+   D  I Q           LK  LE +Q Q++   I LAE  ++
Sbjct: 1223 QLLVKTKKELADSKQAETDHLILQAS---------LKGELEASQQQVEVYKIQLAEITSE 1273

Query: 919  MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF 978
               + + ++   + +   L+ Y   Q+ +  L  E +A K E  T+              
Sbjct: 1274 KHKIHEHLKTSAEQHQRTLSAY---QQRVTALQEECRAAKAEQATVTS------------ 1318

Query: 979  EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLI 1038
                 +F++ +  + + L +Q  K S+S+ E +  KQE + L+  I  L+  L+D    +
Sbjct: 1319 -----EFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372

Query: 1039 EKSHEMERALSRKTDEL----NKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL 1094
            + +    + L  + D L    NK L++   K  E++     +  EN    SE     + L
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQL 1432

Query: 1095 QKQHVPL-----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1149
              Q+  L     +QV  L++    T+E L+++L  M+           +L QL +N+  +
Sbjct: 1433 TSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKME----------AQLFQL-KNEPTT 1481

Query: 1150 SVPLAEHLQIKEAFEKE------VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1203
              P++    +K   E+       + +   +  E E       E VS   +  Q+ +Q L 
Sbjct: 1482 RSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541

Query: 1204 KLETREVVDLSKYKATKSDLETQISSLNEKLANLN 1238
              ET+    L   + TK +L  ++SS  +   +LN
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLN 1576



 Score =  139 bits (350), Expect = 2e-32
 Identities = 228/1082 (21%), Positives = 458/1082 (42%), Gaps = 186/1082 (17%)

Query: 429  LKKELEAMRTFCES--------AKQDRLK-LQNELAHKVAECKALALECERVKEDSDEQI 479
            L+KE+E +R+   +        A  +RL  L  E A    +C +L  E  ++K++ ++ +
Sbjct: 51   LEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSV 110

Query: 480  KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVK 539
             ++ DA K+++             Q+H   +KE              E LK++L  ++ K
Sbjct: 111  TKMGDAHKELE-------------QSHINYVKE-------------IENLKNELMAVRSK 144

Query: 540  YEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKEL---------------SM 584
            Y    A + K   +    ++ + E  + +    +  K+LQ+E+                 
Sbjct: 145  YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204

Query: 585  CEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 642
             +   ++K   VT+++   +A     +  ++   E+   +K+    EV E   ++    +
Sbjct: 205  LDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAK 264

Query: 643  EHEKSLSEIRQLKREL-ENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQT 701
            EHE  ++++ +LK  L +  +A      K  E E    R    +     +I  + L+  T
Sbjct: 265  EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENT 324

Query: 702  LQKEI--EKV-YLDNKLLK-EQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 757
              +++  EKV +L++ L + E  H++  +   +   LK+  +M   H  I D+   +  D
Sbjct: 325  FVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH--IKDEFFHERED 382

Query: 758  VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF-VPPEKHEKEIIALKSNIVELKKQLSE 816
            +  K  E  L  E+     + L  +++ L   F    E+H +E+ +LK    + +K++SE
Sbjct: 383  LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE---QHQKEISE 439

Query: 817  LKKKCGEDQEK--------IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR 868
            L +    D EK        I  L  +  NL++      +  ++  E+   L   L ++  
Sbjct: 440  LNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAG 499

Query: 869  ELLDVKKKFEDINQEFVKIKDKNEIL---------KRNLENTQNQIKAEYISLAEHEAKM 919
            +   + ++FE + Q+  +  D +E+          K  L  T N+++ E   L   +  +
Sbjct: 500  K---ISQEFESMKQQ--QASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554

Query: 920  SSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF- 978
              L  +++ +Q+ N   L +  +    +  L  +I +  +E D     +K  +  + +F 
Sbjct: 555  PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614

Query: 979  EECERK-------------------------------FKATEKELKDQLSEQTQKYSV-- 1005
            ++CER+                                + T KE KDQ  ++ +K  V  
Sbjct: 615  KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE-KDQNDQKLEKLMVQM 673

Query: 1006 ---SEE------EVKKNKQENDKLKKEIFTLQKDL------RDKTVLIEKSHEMERALS- 1049
               SE+      EVK   +EN+KL  E   L +DL      ++  +L E   ++E+ L  
Sbjct: 674  KVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733

Query: 1050 --RKTDELNKQLKDLSQKYTEVKNVKEKLVEE---NAKQTSEILAVQNLLQKQHVPLEQV 1104
               + D LNK L++   +   VK      ++E      + SE   V N+LQ     L ++
Sbjct: 734  MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793

Query: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQT-VTKLHQLLENQKNSSVPLAEHLQ----I 1159
               K +L    +    EL+   +C ++E      +L  LL + +   V L + L+     
Sbjct: 794  NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853

Query: 1160 KEAFEKEVGIIKASLREKEEESQN---KMEEVSKL--QSEVQNTKQA--LKK-------L 1205
            KEA + ++  +K +  +   E+QN   ++EEVS+   +SE+ N K+   +K+       L
Sbjct: 854  KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913

Query: 1206 ETREVVD-----------LSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV------ 1248
            E +E+ D           L+K  + K+D  + +  L EK+ NL ++ +E  E++      
Sbjct: 914  EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLV 973

Query: 1249 -LHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITE-------LQRRIQESAKQ 1300
             + AKK+  S++ E + +   +E  ++ +K++   S+  + +       L    ++ ++Q
Sbjct: 974  AVKAKKELDSSRKETQTVKEELE-SLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 1032

Query: 1301 IEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADA 1360
            ++ +  +     + +E L + L   +    T  +  +     I+TLQ   K LE Q+ + 
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092

Query: 1361 DR 1362
             R
Sbjct: 1093 QR 1094



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 142/680 (20%), Positives = 288/680 (42%), Gaps = 100/680 (14%)

Query: 804  KSNIVELKKQLSELKKKCGED---------QEKIHALTSENTNLKKM---MSNQYVPVKT 851
            KS   EL+K++ EL+ K   +          E++ AL  E    ++    +  + + +K 
Sbjct: 45   KSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQ 104

Query: 852  HEEVKMT-LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI 910
              E  +T + D   +  +  ++  K+ E++  E + ++ K    K NL+    +     +
Sbjct: 105  EVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQL 164

Query: 911  SLAEHEAKMSSLSQSMRKVQDSNAEILANYRK--------------GQEEIVT-----LH 951
             L+E     ++   +++K+Q+   +I   + +               ++E VT     + 
Sbjct: 165  ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224

Query: 952  AEIKAQKKELDTIQE---CIKVKYAPIVSFEECERKFKATE--------KELKDQLSEQT 1000
            A  +  +K ++++QE    +K  +   V    C+ +  A E         ELK+ L +Q 
Sbjct: 225  ANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC 284

Query: 1001 QKYSVSEEEV-KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQL 1059
            +    SE+ + KK + E + L+K      +D +  ++L++++  +E+ ++ K   L   L
Sbjct: 285  E---ASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTL 341

Query: 1060 KDLSQKY-------TEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1112
            K+L  ++       T + N+K KL  +      E    +  L+     + ++   K+   
Sbjct: 342  KELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE---FKINELLLAKEEQG 398

Query: 1113 GTIENLKEELKSM--QRCYEKEQ-----QTVTKLHQ----------LLENQKNSSVPLAE 1155
              IE LK EL  +  Q CY  EQ     Q++ + HQ          L +++K     + E
Sbjct: 399  CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE 458

Query: 1156 HLQIKEAF-----EKEVGIIK-ASLREKEEESQNKM-EEVSKLQSEVQNTKQALKKLETR 1208
               +KE       EK+  I+   SLRE  E  Q ++ E   K+  E ++ KQ  +  +  
Sbjct: 459  IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQ-QASDVH 517

Query: 1209 EVVDLSKYKATKSD--LET--QISSLNEKLANLNRKYEEVCEEVLHAKKKE---ISAKDE 1261
            E+    +   T+ D  LET  ++   NEKL +      E+   + + ++K    + +  +
Sbjct: 518  ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 577

Query: 1262 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER---- 1317
            ++ +   +E +I    E  D  +  +      +    K+ E ++  I EL   VE+    
Sbjct: 578  RDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637

Query: 1318 ---LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIY-RT 1373
               L+Q +N L+     +     +  Q ++ L  Q+K L +   D +    EV ++Y   
Sbjct: 638  NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE---DKEVLSAEVKSLYEEN 694

Query: 1374 HLLSAAQGHMDEDVQEALLQ 1393
            + LS+ +  +  D++  L Q
Sbjct: 695  NKLSSEKKQLSRDLEVFLSQ 714



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 99/507 (19%), Positives = 202/507 (39%), Gaps = 59/507 (11%)

Query: 240  KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 299
            K   + T +  EL KK    QQ  L +M+     +  +  +Q + +   + EDL++ ++ 
Sbjct: 1135 KKQLQKTMQELELVKK--DAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKI 1192

Query: 300  IQQEQRILLDKVNGLQ---------------LQLNEEVMVADDLESEREKLKSLLAAKEK 344
             +Q+Q  L +++  LQ               L +  +  +AD  ++E + L  L A+ + 
Sbjct: 1193 QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL-ILQASLKG 1251

Query: 345  QHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKED----MLLKQGQMYMADSQCTSPG- 399
            + E S + +E  K +     S+      H     E     +   Q ++     +C +   
Sbjct: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311

Query: 400  ----IPAHMQSRSML--RPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNE 453
                + +  +S  +     L+       S +E E  K+E E +    +  K      QN 
Sbjct: 1312 EQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNN 1371

Query: 454  LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 513
            L   V+E + L  E + + E  ++ +++      ++++++   + +   M++        
Sbjct: 1372 LQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ 1431

Query: 514  LTSEAASGNHRLTEELKDQLKDLKVKY----EGASAEVGKLRNQIKQ--NEMIVEEFKRD 567
            LTS+    N  L    +DQ++ L+ ++    E    ++ K+  Q+ Q  NE         
Sbjct: 1432 LTSQ----NEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSS 1487

Query: 568  EGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLS 627
            +  L    +R   +L + +M        VT  EG+  E +   ++S  +   ++++  L+
Sbjct: 1488 QQSLKNLRERRNTDLPLLDM------HTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541

Query: 628  NEVNE----------KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQV 677
            +   +            ++LV+      KS   +  L RE E   A L + +K  + E  
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE-- 1599

Query: 678  KSRLEQKSGELGKKITELT-LKNQTLQ 703
              R  +++ E  K    L  LKN  LQ
Sbjct: 1600 -IRRLERNQEREKSAANLEYLKNVLLQ 1625


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  178 bits (452), Expect = 3e-44
 Identities = 249/1159 (21%), Positives = 503/1159 (43%), Gaps = 162/1159 (13%)

Query: 244  ENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-----QNIQDLEIENEDLKERLR 298
            E   K   L ++   LQQ   + + ++  +K+  +E+     +N ++L +  ++LK++  
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099

Query: 299  KIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAKEKQHE--ESLRT 352
             + QE+   + K   L    +    V + L+ +    +EK + LL  +E+  E  + +  
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159

Query: 353  IEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP 412
            IE LKN  K  E     +  H    + ++  K  + Y      T        + R +L+ 
Sbjct: 1160 IENLKNELKNKEL----TLEHMETERLELAQKLNENYEEVKSIT--------KERKVLKE 1207

Query: 413  LELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQ------NELAHKVAECKALAL 466
            L+ S  ++  +    I + E   ++T  E  K   + L+      +EL   V+E  A  +
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQII 1266

Query: 467  ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLT 526
              + + E S  ++++    L + Q+ +  +  +V + Q     L E LT ++ + +    
Sbjct: 1267 NTQDL-EKSHTKLQEEIPVLHEEQE-LLPNVKEVSETQETMNEL-ELLTEQSTTKDSTTL 1323

Query: 527  EELKDQLKDLKVKYEGASAEVGKL---RNQIK--------QNEMIVEEFKRDEGKLIEEN 575
              ++ +   L  K++ +  E+  L   R+ +K        +++ + E  +    K+ E  
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383

Query: 576  KRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAK 635
             + ++ L+M E + E   + V+EME    + SA L + I             +E+   AK
Sbjct: 1384 SKQEQSLNMKEKDNETT-KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442

Query: 636  KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK----SRLEQKSGELGKK 691
            +  +++R  E   SE  QLK   EN+K  +A+H++ EE  +V        E+   EL   
Sbjct: 1443 EKDDLQRLQEVLQSESDQLK---ENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499

Query: 692  ITELTLKNQTLQKEIEKVY--LDNKLL----KEQAHNLT--IEMKNHYVPLKVSEDMKKS 743
            ++E   +  T+QK++E +   L NK+     KE+  N+    E++     LK  ++ +K+
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559

Query: 744  HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIAL 803
             D+ +  +  K+L++T +  E + E++ ++ E + + +    L+      +++ KEI+A 
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619

Query: 804  KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL 863
                 E + Q  ++     E QEK+     E  +LK+    Q + ++  E   + L   L
Sbjct: 1620 MKESQEKEYQFLKMTA-VNETQEKM----CEIEHLKEQFETQKLNLENIETENIRLTQIL 1674

Query: 864  AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT-------QNQIKAEYISLAEHE 916
             +   E+  V K+ +D+      +K + + LK NL  T       Q ++K  ++ L EH+
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQ 1734

Query: 917  A-----------KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 965
                        K + +S   + ++ SN  + A   K QEE+   H  +K Q++ +D   
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID--- 1791

Query: 966  ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1025
                              K +    E  D+LS   +    S  ++++  QE    + ++ 
Sbjct: 1792 ------------------KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833

Query: 1026 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1085
            TL+KD+ +     +K  EME        +L KQ+KD S   +       KL  EN     
Sbjct: 1834 TLKKDVNETQ---KKVSEME--------QLKKQIKDQSLTLS-------KLEIENL---- 1871

Query: 1086 EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK-SMQRCYEKEQQTVTKLHQLLE 1144
                  NL QK H  LE+++++ K     +  ++E LK    +  E  Q+T  +  ++ +
Sbjct: 1872 ------NLAQKLHENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQETKARDLEIQQ 1924

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK 1204
              K + +   EH +  +   +++      + + +++     +E+ K   E+Q  K+ L+ 
Sbjct: 1925 ELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQ--KKELQL 1982

Query: 1205 LETREVVDLSKYKATKSD-LETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEI 1256
            L  +E V++S  K  + + L+ Q  + N  + +       L +K  E  EE+       I
Sbjct: 1983 LRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI------RI 2036

Query: 1257 SAKDEKELLHFSIEQEIKDQKERCDKSLTTITEL------QRRIQESAKQIEAKDNKITE 1310
             AK+  EL    I++ +K ++   D+ + T+ E+        +++   + +      +TE
Sbjct: 2037 VAKERDELRR--IKESLKMER---DQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE 2091

Query: 1311 LLND-VERLKQALNGLSQL 1328
             L +   R+K+ L   S++
Sbjct: 2092 SLREKCSRIKELLKRYSEM 2110



 Score =  175 bits (444), Expect = 2e-43
 Identities = 263/1269 (20%), Positives = 541/1269 (42%), Gaps = 183/1269 (14%)

Query: 263  NLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEV 322
            NL    +++  +  + E +  +  +++  +  ER  K  QE + L+ +++ L+  +    
Sbjct: 509  NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ-LIHEISNLKNLVKHAE 567

Query: 323  MVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDML 382
            +   DLE+E      LL  KE Q          +K   +Y +S  L +     +   + +
Sbjct: 568  VYNQDLENELSSKVELLREKEDQ----------IKKLQEYIDSQKLENIKMDLSYSLESI 617

Query: 383  LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ-----TSYSENEILKKELEAMR 437
                QM        +  + A  +S + LR   L L  +     T+Y + E    +++  +
Sbjct: 618  EDPKQMKQTLFDAETVALDAKRES-AFLRSENLELKEKMKELATTYKQME---NDIQLYQ 673

Query: 438  TFCESAKQDRLKLQNELAHKVAEC-KALALECERVKEDSDEQIKQLEDALKDVQKRMYES 496
            +  E+ K+ ++ L+ EL     E  K  +L   +V +D    + +LE  + D+QK + + 
Sbjct: 674  SQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL-ELEGKITDLQKELNKE 732

Query: 497  EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
              + + ++   + L E       S   RL +E++D+ ++L +     ++E  KL +++  
Sbjct: 733  VEENEALREEVILLSE--LKSLPSEVERLRKEIQDKSEELHI----ITSEKDKLFSEVVH 786

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEME-----------REKKGRKVTEMEGQAKE 605
             E  V+    + GK  ++    Q      + E            +K    + E E   +E
Sbjct: 787  KESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846

Query: 606  LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 665
            +   + LS  A+KF++   +L  E++ K ++L E  RE ++ L+E+ QLK +LEN  + L
Sbjct: 847  I---VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTL 903

Query: 666  AQHVKPEEH----------EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 715
             Q V+ E+           E+VK+ L Q+  +L +    L ++   L+ +I      N  
Sbjct: 904  -QTVEREKTLITEKLQQTLEEVKT-LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961

Query: 716  LKEQAHNLTIEMKNHYVPL-----KVSEDMKKS--------------------------- 743
             +EQ  N    +K H   +     K+SE++ ++                           
Sbjct: 962  TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021

Query: 744  ------------HDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV-SRLETVF 790
                         D  I +  RK+  + Q+  E +  +E ++ E + L  D+   +E   
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081

Query: 791  VPPE---------KHEKEIIALKSNIVELKK--------QLSELKKKCGEDQEKIHALTS 833
               E         K ++EI+A + N    K+        +L+E+++K  E  +++     
Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ 1141

Query: 834  ENTNLKKMMSNQYVPVKTHEEVKMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDK 890
            +  N+++ MS     +   E +K  L +   TL     E L++ +K  +  +E   I  +
Sbjct: 1142 QLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE 1201

Query: 891  NEILK-----------------RNLE----NTQNQIKAEYISLAEHEAKMSSLSQSMRKV 929
             ++LK                 R +E     T+ ++K  +I L EH+    ++ +  R V
Sbjct: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ---ETIDELRRSV 1258

Query: 930  QDSNAEIL------ANYRKGQEEIVTLH--AEIKAQKKELDTIQECIKVKYAPIVSFEEC 981
             +  A+I+       ++ K QEEI  LH   E+    KE+   QE +       +  E+ 
Sbjct: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE---LLTEQS 1315

Query: 982  ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK--KEIFTLQKDLRDKTVLIE 1039
              K   T   ++ +     +K+  S+EE+K   +E D LK  KE   ++ D + K  + E
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD-QLKEHIRE 1374

Query: 1040 KSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENA---KQTSEILAVQNLLQK 1096
               +++ + S++   LN + KD   + T++ +  E+   +++   +   E+L +   LQ+
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKD--NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

Query: 1097 QHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1149
             H  ++ V       + L++ L    + LKE +K +   + + ++ +   H  L+ Q+ +
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492

Query: 1150 SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE 1209
               L  +L  KE    E+  I+  L    ++ QNK++E+ + + E  N KQ  +  E  +
Sbjct: 1493 INELRVNLSEKET---EISTIQKQLEAINDKLQNKIQEIYE-KEEQFNIKQISEVQE--K 1546

Query: 1210 VVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSI 1269
            V +L ++K  +   ++ + S+  K+  L  + +E  EE+    +  I  K+E + +  ++
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI----QIMIKEKEEMKRVQEAL 1602

Query: 1270 EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT 1329
            + E    KE   + +  + E Q +  +  K      N+  E + ++E LK+         
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV--NETQEKMCEIEHLKEQFETQKLNL 1660

Query: 1330 YTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQ- 1388
                    R +Q++     +++S+ ++  D  R  +E + + R  L    +  +  D++ 
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDL-RSVEETLKVERDQLKENLRETITRDLEK 1719

Query: 1389 EALLQIIQM 1397
            +  L+I+ M
Sbjct: 1720 QEELKIVHM 1728



 Score =  135 bits (340), Expect = 3e-31
 Identities = 247/1231 (20%), Positives = 525/1231 (42%), Gaps = 198/1231 (16%)

Query: 274  KSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGL---QLQLNEEVMVADDLES 330
            K  Q  H  ++ +  E +DL+     +Q E   L + +  +    L+  EE+ VA     
Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487

Query: 331  EREK----LKSLLAAKEKQHEESLRTIEALKNRFK-----YFESDHLGSGSHFSNRKEDM 381
            E+E+    L+  L+ KE +     + +EA+ ++ +      +E +   +    S  +E +
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547

Query: 382  L-LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 440
              LKQ + +          I + M        LEL+   Q S  E +I+ KE E M+   
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKM--------LELTNRLQESQEEIQIMIKEKEEMKRVQ 1599

Query: 441  ESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLE-DALKDVQKRMYESEGK 499
            E+ + +R +L+      VA          ++KE  +++ + L+  A+ + Q++M E E  
Sbjct: 1600 EALQIERDQLKENTKEIVA----------KMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649

Query: 500  VKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEM 559
             +Q +T  L L E++ +E    N RLT+ L + L++++      + E   LR+  +  ++
Sbjct: 1650 KEQFETQKLNL-ENIETE----NIRLTQILHENLEEMR----SVTKERDDLRSVEETLKV 1700

Query: 560  IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEK 618
              ++ K +  + I  +   Q+EL +  M  ++    + ++ G   E + +++ +    E 
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760

Query: 619  FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR-----------QLKRELENVKAKLA- 666
              +   +   ++ E+ +      +E ++++ ++R            ++++LEN  AKL  
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820

Query: 667  --QHVKPEEHEQVKSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLDNKLLKEQ 719
              Q +K  EH+ +   L++   E  KK++E+      +K+Q+L   + K+ ++N  L ++
Sbjct: 1821 KIQELKANEHQLIT--LKKDVNETQKKVSEMEQLKKQIKDQSLT--LSKLEIENLNLAQK 1876

Query: 720  AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-KLLDVTQKYTEKKLEMEKLLLENDS 778
             H    EMK+    +K  +++++  + +   L R +L +  Q+   + LE+++ L     
Sbjct: 1877 LHENLEEMKS---VMKERDNLRRVEETL--KLERDQLKESLQETKARDLEIQQELKTARM 1931

Query: 779  LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL--TSENT 836
            LSK+    ETV    EK  ++ I +     +L K   EL+KK  E Q+K   L    E+ 
Sbjct: 1932 LSKE--HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989

Query: 837  NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI--L 894
            N+     N+   +K   E +     ++   N +L   KK  E + +  +  K+++E+  +
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL--TKKLHESLEEIRIVAKERDELRRI 2047

Query: 895  KRNLENTQNQIKAEYISLA-----EHEAK---------MSSLSQSMRKVQDSNAEILANY 940
            K +L+  ++Q  A    +       H+ K            L++S+R+      E+L  Y
Sbjct: 2048 KESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRY 2107

Query: 941  RKGQEEI-------VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE-------CERKFK 986
             +  +         + L  EI+ QK+    ++  + + Y      E+       C  +F 
Sbjct: 2108 SEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFH 2167

Query: 987  ATEKELKDQLS-----EQTQKYSVSE------EEVKKNK----------QENDKLKKEIF 1025
               K+LK  LS     ++ Q  S+++      +EV+K K          Q+ D   +E+ 
Sbjct: 2168 RIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELR 2227

Query: 1026 TLQ----KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK---EKLVE 1078
             L+     DL  + +L + S     ++  +  ++    K+++Q   E  N +   EKL  
Sbjct: 2228 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287

Query: 1079 ENAKQTSEILAVQNLLQKQHVPL--------EQVEALKKSLNGTIENLKEELKSMQRCYE 1130
               K+   I  V N    + + +        E+   + K     +++LKE+ + + + Y+
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347

Query: 1131 KEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1190
              + ++    Q+    +++  P       +   EK +  ++ SL E +E + +K  ++ K
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK-IRELENSLHEAKESAMHKESKIIK 2406

Query: 1191 LQSEVQ---------------------NTKQALKKLETREVVDLSKYKATKSDLETQISS 1229
            +Q E++                      TK+ ++ L+ +  +    YK    DL+ ++  
Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK 2466

Query: 1230 LN-EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTIT 1288
            ++ EK+ N     +E+          + + + +KE++    E   + Q+ +    ++  T
Sbjct: 2467 IDLEKMKNAKEFEKEI-------SATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHT 2519

Query: 1289 ELQ-----------RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1337
            + Q             I ++ K +  K   I  L  ++ +LKQ    L           K
Sbjct: 2520 DPQPSNKPLTCGGGSGIVQNTKALILKSEHI-RLEKEISKLKQQNEQL----------IK 2568

Query: 1338 RQSQLIDTLQH---QVKSLEQQLADADRQHQ 1365
            ++++L+   QH   +VK+ +++    +   Q
Sbjct: 2569 QKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599



 Score =  110 bits (274), Expect = 1e-23
 Identities = 188/1043 (18%), Positives = 437/1043 (41%), Gaps = 113/1043 (10%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-----QNIQDLEIEN 290
            + L +   EN  + R + K+   L+    T   +   +K + RE      +  ++L+I +
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727

Query: 291  EDLKERLRKIQQEQRILLDKVNGLQ-----LQLNEEVMVADDLESEREKLKSLLAAKEKQ 345
              LKE    I + + I+ +K N +      L+ + + + A DL+ + E   + +  KE+Q
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787

Query: 346  HE-ESLRTIEALK-NRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 403
               + LR I + K ++    + D   S +    + +++   + Q+               
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE------ 1841

Query: 404  MQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKA 463
                           +Q   SE E LKK+++         + + L L  +L   + E K+
Sbjct: 1842 ---------------TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886

Query: 464  LALECE---RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 520
            +  E +   RV+E    +  QL+++L++ + R  E +   ++++T  +  KEH   E   
Sbjct: 1887 VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ---QELKTARMLSKEH--KETVD 1941

Query: 521  GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEG---KLIEENKR 577
                   E   Q+ D++   + +  E+ K   ++++ E+ +   K D     K I E ++
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001

Query: 578  LQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL-SIPAEKFENMKSSLSNEVNEKAKK 636
            L+K+     +  +       ++  +  E   ++ + +   ++   +K SL  E ++    
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIAT 2061

Query: 637  LVEM---EREHEKSLSEIR-----------QLKRELENVKAKLAQHVKPEEHEQVKSRLE 682
            L EM   +R++ +   E R            L+ +   +K  L ++ + ++H +  +RL 
Sbjct: 2062 LREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLS 2121

Query: 683  ---QKSGELGKKITELTLKNQTLQ----KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK 735
               +K  E  K+++     N +L     K IEK++  N+    + H +  ++K  YV   
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLK--YVLSY 2179

Query: 736  VSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEK 795
            V++  ++ H++I +      +D  +K  E  ++++ L  + D  S+++  L+ +    + 
Sbjct: 2180 VTKIKEEQHESI-NKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-LNQNMDL 2237

Query: 796  HEKEIIA--LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 853
            H +EI+    +S    +K +  ++     E  + +    +   +++K+ +          
Sbjct: 2238 HIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297

Query: 854  EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVK----IKDKNEILKRNLENTQNQIK--A 907
            +V    N+ +     E  + +++   I++E+ +    +K+KNE L +N +  +  +   A
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGA 2357

Query: 908  EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 967
            +     +        S++ +   +   E+  +  + +E  +   ++I   +KEL+   + 
Sbjct: 2358 QVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417

Query: 968  IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKN--KQENDKLKKEIF 1025
            I    A +    +C  K K T + L+D+++   + Y    E++K    K + +K+K    
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKN--- 2474

Query: 1026 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1085
                          K  E E + ++ T E  K++         ++ ++E L      Q +
Sbjct: 2475 -------------AKEFEKEISATKATVEYQKEV---------IRLLRENLRRSQQAQDT 2512

Query: 1086 EILAVQNLLQKQHVPL-----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140
             +++     Q  + PL       +    K+L    E+++ E K + +  ++ +Q + + +
Sbjct: 2513 SVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE-KEISKLKQQNEQLIKQKN 2571

Query: 1141 QLLENQKNSS--VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNT 1198
            +LL N ++ S  V   +   +K    K+V    +    K   + +K ++++  Q + +N 
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNL 2631

Query: 1199 KQALKKLETREVVDLSKYKATKS 1221
            +  + K   +     S+ K+  S
Sbjct: 2632 QDPVPKESPKSCFFDSRSKSLPS 2654



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 158/826 (19%), Positives = 342/826 (41%), Gaps = 124/826 (15%)

Query: 660  NVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK---NQTLQKEIEKVYLDNKLL 716
            N K ++   + P   ++  + L+  S     K T    +   ++ L K   K  +D   L
Sbjct: 299  NAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD---L 355

Query: 717  KEQAHNLTIEM------KNHYVPLKVSEDM-KKSHDAIIDDLNRKLLDVTQKYTEKKLEM 769
            K+Q   +++E       K+    L   +D+ +K  +  I++L R L+  +    +++L+ 
Sbjct: 356  KKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKA 415

Query: 770  EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH 829
            ++       L K +++++      + +    I  K++ + +       +  C E     +
Sbjct: 416  KRKRRVTWCLGK-INKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSN 474

Query: 830  ALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD 889
             L +    L ++  N    +   E ++  LN   A  +  +LD ++   +  +  +K+K+
Sbjct: 475  TLDT----LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE 530

Query: 890  KN----------------------------------EILKRNLEN-----------TQNQ 904
            KN                                  E+  ++LEN            ++Q
Sbjct: 531  KNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQ 590

Query: 905  IK--AEYISLAEHEAKMSSLSQSMRKVQDS--------NAEILANYRKGQEEIV-TLHAE 953
            IK   EYI   + E     LS S+  ++D         +AE +A   K +   + + + E
Sbjct: 591  IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE 650

Query: 954  IKAQKKELDTIQECIKVKYAPIVSFEECERKFKA-TEKELKDQLSEQTQKYSVSEEEVKK 1012
            +K + KEL T  + ++       S  E ++K +   EKEL+   +E T+  S+ + +V K
Sbjct: 651  LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK 710

Query: 1013 NKQENDKLKKEIFTLQKD----------LRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
            +   N +L+ +I  LQK+          LR++ +L+ +     ++L  + + L K+++D 
Sbjct: 711  DLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL----KSLPSEVERLRKEIQDK 766

Query: 1063 SQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1122
            S++   + + K+KL  E   + S +  +   + K    L   ++  KS +   +N K   
Sbjct: 767  SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826

Query: 1123 KSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQ 1182
               ++ Y+   +   +++Q + N    +      L    A + E+      L+EK  E Q
Sbjct: 827  MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL---GALKTELSYKTQELQEKTREVQ 883

Query: 1183 NKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLET------QISSLNEKL-- 1234
             ++ E+ +L+ +++N    L+ +E  + +   K + T  +++T       +  L E L  
Sbjct: 884  ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943

Query: 1235 ------------ANLNRKYEEVCEEVLHAKKKE------ISAKDEKEL-LHFSIEQEIKD 1275
                         N+N   +E     L + K+       + +K  +E+  +  +E+   +
Sbjct: 944  ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003

Query: 1276 QKERCDKSLTTITELQRRIQESAKQIEA--KDNKITELLNDVERLKQALNGLSQ-LTYTS 1332
             K+   + +  I + Q    ++ + + A  KDN+I E    +  L Q  N L Q L    
Sbjct: 1004 TKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVI 1063

Query: 1333 GNPTKRQSQLIDTLQHQVKSLEQ--QLADADRQHQEVIAIYRTHLL 1376
                + ++ L + ++  +++ E+   L D  ++ QE++A  + H +
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAI 1109


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  177 bits (449), Expect = 6e-44
 Identities = 234/1021 (22%), Positives = 459/1021 (44%), Gaps = 159/1021 (15%)

Query: 446  DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 504
            +RL+ + E+ +  VA+ + L  +C  +K D D+    LE  L  V+K  + +E KVK + 
Sbjct: 928  ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDD----LELTLTKVEKEKHATENKVKNLS 983

Query: 505  THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVK--------------------YEGAS 544
                AL+E++ S+       L E  +  L DL+V+                     EG+ 
Sbjct: 984  EEMTALEENI-SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042

Query: 545  AEVGKLR-----------NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
             +  KLR             +K ++  + + + D+ ++ E+ K+ + ELS  + + + + 
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102

Query: 594  RKVTEMEGQAKELSAK---LALSIPAE-----KFENMKSSLSNEVNEKAKKL-------- 637
                + + + KEL A+   L   I AE     K E  +S L+ E+ E +++L        
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATS 1162

Query: 638  --VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG----ELGKK 691
              +EM ++ E   +E ++++R+LE             +HE   + L +K      ELG++
Sbjct: 1163 AQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAATLRKKQADSVAELGEQ 1210

Query: 692  ITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDL 751
            I  L    Q L+KE  ++ ++   +      L+    N     +  ED          ++
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ-------FSEI 1263

Query: 752  NRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELK 811
              K    TQ   +  ++  +L  +N  LS  V   E++     K ++   AL   + ELK
Sbjct: 1264 KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ---ALTQQLEELK 1320

Query: 812  KQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELL 871
            +Q+ E  K         HAL S   +   ++  QY   +  +E K  L   L+K N E+ 
Sbjct: 1321 RQMEEETKA---KNAMAHALQSSRHDCD-LLREQY---EEEQEAKAELQRALSKANSEVA 1373

Query: 872  DVKKKFE-DINQEFVKIKD-KNEILKR----------------NLENTQNQIKAEYISLA 913
              + K+E D  Q   ++++ K ++ +R                +LE T+ +++ E   L 
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433

Query: 914  EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKY 972
                +  +   ++ K Q +  ++LA +++  +E     AE++A +KE  ++  E  K++ 
Sbjct: 1434 RDLERSHTACATLDKKQRNFDKVLAEWKQKLDES---QAELEAAQKESRSLSTELFKMRN 1490

Query: 973  APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLR 1032
            A     ++ E   +   K L++++S+ T++ +    E  KN QE +K KK +   + DL+
Sbjct: 1491 AYEEVVDQLET-LRRENKNLQEEISDLTEQIA----ETGKNLQEAEKTKKLVEQEKSDLQ 1545

Query: 1033 DKTVLIEKSHEMERA-LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQ 1091
                 +E S E E + + R   EL++   +L +K  E     E+L + N+++ +E  A+Q
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQL-KRNSQRAAE--ALQ 1602

Query: 1092 NLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV 1151
            ++L  +         LKK + G +  ++ +L    R   + Q+ +  +   L   K+S +
Sbjct: 1603 SVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL---KDSQL 1659

Query: 1152 PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVV 1211
             L + L+  E  ++++ I+       E  +   +EE+ +++  ++ T++  ++L  +E++
Sbjct: 1660 HLDDALRSNEDLKEQLAIV-------ERRNGLLLEELEEMKVALEQTERT-RRLSEQELL 1711

Query: 1212 DLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF 1267
            D S          T + +  +KL    A    + E   +E  +A++K   A  +  ++  
Sbjct: 1712 DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE 1771

Query: 1268 SI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITELLNDVE 1316
             +  EQ+     ER  K+L  T+ +LQ R+ E+         KQI+  +N++ EL N+++
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD 1831

Query: 1317 ----RLKQALNG-------LSQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQLADADR 1362
                R  +AL G       + ++TY +    K   R   L+D LQ +VKS ++Q  +A+ 
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891

Query: 1363 Q 1363
            Q
Sbjct: 1892 Q 1892



 Score =  142 bits (357), Expect = 3e-33
 Identities = 197/919 (21%), Positives = 401/919 (43%), Gaps = 141/919 (15%)

Query: 495  ESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQI 554
            E+E ++  M+  F   KE L    A            + K+L+ K      E   L+ Q+
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEA------------RRKELEEKMVSLLQEKNDLQLQV 895

Query: 555  K-QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 613
            + + E +++  +R EG            L   ++  E K +++TE   + +E++++L   
Sbjct: 896  QSETENLMDAEERCEG------------LIKSKILLEAKVKELTERLEEEEEMNSELVAK 943

Query: 614  IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-- 671
                  E+  SSL  ++++    L ++E+E   + ++++ L  E+  ++  +++  K   
Sbjct: 944  --KRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001

Query: 672  ---EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 728
               E H+Q    L+ +      K+  L   N  L+++ +   L+  L +E+     +E  
Sbjct: 1002 SLQEAHQQTLDDLQVEED----KVNGLIKINAKLEQQTDD--LEGSLEQEKKLRADLERA 1055

Query: 729  NHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS-------LSK 781
                  K+  D+K S ++I+D  N K   + +K  +K+ E+ +L  + D          K
Sbjct: 1056 KR----KLEGDLKMSQESIMDLENDKQ-QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK 1110

Query: 782  DVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNL 838
             +  L+      E+ E+EI A  +   +++KQ S+L ++  E  E++      TS    +
Sbjct: 1111 KIKELQARI---EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167

Query: 839  KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL 898
             K    ++  ++   E     ++  A T      ++KK  D   E  +  D  + +K+ L
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAAT------LRKKQADSVAELGEQIDNLQRVKQKL 1221

Query: 899  ENTQNQIKAEYISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 954
            E  ++++K E   +A +        S++ ++ R V+D  +EI A   K +++   +H ++
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA---KDEQQTQLIH-DL 1277

Query: 955  KAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE-LKDQLSEQTQKYSVSEEEVKKN 1013
              QK  L T               +  E   +  EKE L  QL++  Q  +   EE+K+ 
Sbjct: 1278 NMQKARLQT---------------QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322

Query: 1014 KQENDKLKKEI-FTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQLKDLSQKY-TE 1068
             +E  K K  +   LQ    D  +L E+  E + A   L R   + N ++     KY T+
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382

Query: 1069 VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELK----- 1123
                 E+L E   K    +   +   +  +     +E  K+ L G +E+L  +L+     
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 1124 -----SMQRCYEK-----EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKAS 1173
                   QR ++K     +Q+      +L   QK S     E  +++ A+E+ V  ++  
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

Query: 1174 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLE-TREVVDLSKYKATKSDLETQISSLNE 1232
             RE    ++N  EE+S L  ++  T + L++ E T+++V+  K     SDL+  +     
Sbjct: 1503 RRE----NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK-----SDLQVAL----- 1548

Query: 1233 KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQR 1292
                     EEV   + H + K +  + E   +   +++++ ++ E        I +L+R
Sbjct: 1549 ---------EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE-------IEQLKR 1592

Query: 1293 RIQESAKQIEAKDNKITELLNDVERLKQALNG-LSQLTYTSGNPTKRQSQL---IDTLQH 1348
              Q +A+ +++  +      ND  RLK+ + G L+++    G+  ++ ++    + T+Q 
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652

Query: 1349 QVKSLEQQLADADRQHQEV 1367
            Q+K  +  L DA R ++++
Sbjct: 1653 QLKDSQLHLDDALRSNEDL 1671



 Score =  137 bits (345), Expect = 7e-32
 Identities = 226/1121 (20%), Positives = 450/1121 (40%), Gaps = 181/1121 (16%)

Query: 284  QDLEIENEDL---KERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESERE---KLKS 337
            +D E   E+L   + R ++++++   LL + N LQLQ+  E     D E   E   K K 
Sbjct: 858  EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917

Query: 338  LLAAKEKQHEESL-------------------------RTIEALKNRFKYFESDHLGSGS 372
            LL AK K+  E L                         R I+ L+      E +   + +
Sbjct: 918  LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN 977

Query: 373  HFSNRKEDM---------LLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSY 423
               N  E+M         L K+ +      Q T   +       + L  +   L  QT  
Sbjct: 978  KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037

Query: 424  SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKED---SDEQIK 480
             E  +  ++ + +R   E AK+   KL+ +L         L  + ++++E     + ++ 
Sbjct: 1038 LEGSL--EQEKKLRADLERAKR---KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092

Query: 481  QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 540
            QL+  + D Q    + + K+K++Q     L+E + +E     H L  +++ Q  DL  + 
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-----HTLRAKIEKQRSDLAREL 1147

Query: 541  EGASAEV----GKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV 596
            E  S  +    G    QI+ N+    EF++    L  E   LQ E +   + R+K+   V
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATL-RKKQADSV 1204

Query: 597  TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 656
             E+  Q   L          +K E  KS L  E+++ A  +  + +         R ++ 
Sbjct: 1205 AELGEQIDNLQRV------KQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258

Query: 657  ELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITE-------LTLKNQTLQKEIEK 708
            +   +KAK  Q  +   +    K+RL+ ++GEL  ++ E       LT   Q L +++E+
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318

Query: 709  V--YLDNKLLKEQAHNLTIEMKNHYVPL-----KVSEDMKKSHDAIIDDLNRKLLDVTQK 761
            +   ++ +   + A    ++   H   L     +  ++ K      +   N ++     K
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378

Query: 762  Y-------TEKKLEMEKLLLEN---------------DSLSKDVSRL----ETVFVPPEK 795
            Y       TE+  E +K L +                 SL K   RL    E +    E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438

Query: 796  HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK---MMSNQYVPV--- 849
                   L        K L+E K+K  E Q ++ A   E+ +L      M N Y  V   
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498

Query: 850  --------KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 901
                    K  +E    L + +A+T + L + +K  + + QE   ++   E ++ +LE+ 
Sbjct: 1499 LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558

Query: 902  QNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 961
            +++I    + L++ ++++       RKV + + EI    R  Q     L + + A   E+
Sbjct: 1559 ESKILRVQLELSQVKSELD------RKVIEKDEEIEQLKRNSQRAAEALQSVLDA---EI 1609

Query: 962  DTIQECIKVKYAPIVSFEECE-------RKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1014
             +  + +++K        E E       R+   T+K L+    +        ++ ++ N+
Sbjct: 1610 RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669

Query: 1015 QENDKL---KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1071
               ++L   ++    L ++L +  V +E++    R   ++  + + +++ L  + T + N
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLIN 1729

Query: 1072 VKEKL--------------------VEENAKQT-SEILAVQNLLQKQHVPLEQVEALKKS 1110
             K+KL                     EE AK+  ++   +   L+K+      +E +KK+
Sbjct: 1730 TKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 1111 LNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1162
            L  T+++L+          LK  ++  +K +  V +L   L+ ++      AE L+    
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRG---AEALKGAHK 1846

Query: 1163 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1222
            +E++V  +     E  +      + V KLQ++V++ K+  ++ E +    LS+ +  + +
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE 1906

Query: 1223 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1263
            LE      +   + +N+         L AK +++ ++  +E
Sbjct: 1907 LEEAAERADIAESQVNK---------LRAKSRDVGSQKMEE 1938



 Score =  121 bits (303), Expect = 5e-27
 Identities = 206/1004 (20%), Positives = 415/1004 (41%), Gaps = 155/1004 (15%)

Query: 533  LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKK 592
            L+ +++  +G  + +  L    KQ   I+      EG+ I+     +K L+  +++RE+ 
Sbjct: 703  LEGIRICRKGFPSRI--LYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQF 760

Query: 593  GRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE-----VNEKAKKLVE-------- 639
                T++  +A  L   L   +  EK   + +S         +  + KK++E        
Sbjct: 761  RFGNTKVFFKAGLLG--LLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCI 818

Query: 640  -------MEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK---SRLEQKSGELG 689
                   M  +H   ++   ++K  L++ +A+       E+ E+ K   +R E +  EL 
Sbjct: 819  QYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELE 878

Query: 690  KKITELTLKNQTLQKEIE-------------------KVYLDNKLLKEQAHNL--TIEMK 728
            +K+  L  +   LQ +++                   K+ L+ K +KE    L    EM 
Sbjct: 879  EKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK-VKELTERLEEEEEMN 937

Query: 729  NHYVPLKVS-EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL- 786
            +  V  K + ED   S    IDDL   L  V ++    + +++ L  E  +L +++S+L 
Sbjct: 938  SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT 997

Query: 787  ----------ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 836
                      +      +  E ++  L     +L++Q  +L+    ++++    L     
Sbjct: 998  KEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057

Query: 837  NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKR 896
             L+  +      +   E  K  + + L K   EL  ++ K +D     ++ + K + L+ 
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117

Query: 897  NLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQD--------SNAEILANYRKGQE--- 945
             +E  + +I+AE+   A+ E + S L++ + ++ +        ++A+I  N ++  E   
Sbjct: 1118 RIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177

Query: 946  -----EIVTLHAEIKA---QKKELDTIQEC--------------------IKVKYAPIVS 977
                 E  TL  E  A   +KK+ D++ E                     +K++   + S
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237

Query: 978  FEECERKFKA----TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1033
              E   K K+    T + ++DQ SE   K     + +     +  +L+ +   L   + +
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297

Query: 1034 KTVLIEKSHEMERALSRKTDELNKQLKD---------------------LSQKYTEVKNV 1072
            K  LI +  + ++AL+++ +EL +Q+++                     L ++Y E +  
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 1073 KEKLVEENAKQTSEILAVQNLLQKQHVP-LEQVEALKKSLNGTIENLKEELKSM-QRCYE 1130
            K +L    +K  SE+   +   +   +   E++E  KK L   ++  +E  ++   +C  
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417

Query: 1131 KE---QQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1187
             E   Q+   ++  L+ + + S    A   + +  F+K +   K  L E + E +   +E
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477

Query: 1188 VSKLQSEVQNTKQALKKLETREVVD-LSKYKATKSDLETQISSLNEKLANLNRKYEEVCE 1246
               L +E+   + A +     EVVD L   +    +L+ +IS L E++A   +  +E   
Sbjct: 1478 SRSLSTELFKMRNAYE-----EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQE--- 1529

Query: 1247 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDN 1306
                A+K +   + EK  L  ++E+     +    K L    EL +   E  +++  KD 
Sbjct: 1530 ----AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585

Query: 1307 KITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1366
            +I +L  + +R  +AL  +      S N   R   L   ++  +  +E QL  ++RQ  E
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALR---LKKKMEGDLNEMEIQLGHSNRQMAE 1642

Query: 1367 VIAIYRT--HLLSAAQGHMD------EDVQEALLQIIQMRQGLV 1402
                 RT    L  +Q H+D      ED++E  L I++ R GL+
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ-LAIVERRNGLL 1685


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  176 bits (447), Expect = 1e-43
 Identities = 226/1045 (21%), Positives = 456/1045 (43%), Gaps = 163/1045 (15%)

Query: 446  DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 504
            +RL+ + E+ A   A+ + L  EC  +K D D+    LE  L  V+K  + +E KVK + 
Sbjct: 924  ERLEDEEEMNAELTAKKRKLEDECSELKRDIDD----LELTLAKVEKEKHATENKVKNLT 979

Query: 505  THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS----AEVGKLRNQIKQNEMI 560
                 L E + ++       L E  +  L DL+ + +  +    A+V KL  Q+   E  
Sbjct: 980  EEMAGLDE-IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV-KLEQQVDDLEGS 1037

Query: 561  VEEFKRDEGKLIEENKRLQKEL-----SMCEMEREKKG---------------------- 593
            +E+ K+    L    ++L+ +L     S+ ++E +K+                       
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097

Query: 594  --------RKVTEMEGQAKELSAKLALSIPAE-KFENMKSSLSNEVNEKAKKL------- 637
                    +K+ E++ + +EL  +L     A  K E ++S LS E+ E +++L       
Sbjct: 1098 QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1157

Query: 638  ---VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG----ELGK 690
               +EM ++ E   +E ++++R+LE             +HE   + L +K      ELG+
Sbjct: 1158 SVQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAAALRKKHADSVAELGE 1205

Query: 691  KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDD 750
            +I  L    Q L+KE  +  L+   +      +     N     +  ED    H +  ++
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265

Query: 751  LNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 810
              R + D+T        +  KL  EN  LS+ +   E +     + +   +     + +L
Sbjct: 1266 TQRSVNDLTS-------QRAKLQTENGELSRQLDEKEALISQLTRGK---LTYTQQLEDL 1315

Query: 811  KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 870
            K+QL E  K         HAL S   +   ++  QY   +   E K  L   L+K N E+
Sbjct: 1316 KRQLEEEVKA---KNALAHALQSARHDCD-LLREQY---EEETEAKAELQRVLSKANSEV 1368

Query: 871  LDVKKKFE-DINQEFVKIKD-KNEILKR----------------NLENTQNQIKAEYISL 912
               + K+E D  Q   ++++ K ++ +R                +LE T+++++ E   L
Sbjct: 1369 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1428

Query: 913  AEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVK 971
                 + ++ + ++ K Q +  +ILA +++  EE     +E+++ +KE  ++  E  K+K
Sbjct: 1429 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTELFKLK 1485

Query: 972  YAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL 1031
             A   S E  E  FK   K L++++S+ T++   S + + + ++   +L+ E   LQ  L
Sbjct: 1486 NAYEESLEHLET-FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544

Query: 1032 RDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIL-AV 1090
             +    +E  HE E  + R   E N+   ++ +K  E    K++ +E+  +    ++ ++
Sbjct: 1545 EEAEASLE--HE-EGKILRAQLEFNQIKAEIERKLAE----KDEEMEQAKRNHLRVVDSL 1597

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            Q  L  +     +   +KK + G +  ++ +L    R   + Q+ V  L  LL   K++ 
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL---KDTQ 1654

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
            + L + ++  +  ++ + I+       E  +     E+ +L++ V+ T+++ +KL  +E+
Sbjct: 1655 IQLDDAVRANDDLKENIAIV-------ERRNNLLQAELEELRAVVEQTERS-RKLAEQEL 1706

Query: 1211 VDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK-------------- 1252
            ++ S+      +  + L  Q   ++  L+ L  + EE  +E  +A+              
Sbjct: 1707 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766

Query: 1253 ---KKEISAKDEKELLHFSIEQEIKDQKERCDKS--------LTTITELQRRIQESAKQI 1301
               KKE       E +  ++EQ IKD + R D++           + +L+ R++E   ++
Sbjct: 1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL 1826

Query: 1302 EAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADAD 1361
            EA+  +  E +  + + ++ +  L+  T        R   L+D LQ +VK+ ++Q  +A+
Sbjct: 1827 EAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1886

Query: 1362 RQHQEVIAIYR--THLLSAAQGHMD 1384
             Q    ++ +R   H L  A+   D
Sbjct: 1887 EQANTNLSKFRKVQHELDEAEERAD 1911



 Score =  149 bits (377), Expect = 1e-35
 Identities = 219/1011 (21%), Positives = 416/1011 (41%), Gaps = 127/1011 (12%)

Query: 462  KALALECERVKEDSD--EQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA 519
            K L    ER KE +   E+  +L++AL+  + R  E E K+  +      L+  L  +A 
Sbjct: 837  KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ--LQVQAE 894

Query: 520  SGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 579
              N    EE  DQL   K++ E   A+V ++  +++  E +  E    + KL +E   L+
Sbjct: 895  QDNLADAEERCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951

Query: 580  K-----ELSMCEMEREK-----KGRKVTEMEGQAKELSAKLALSIPA--EKFENMKSSLS 627
            +     EL++ ++E+EK     K + +TE      E+ AKL     A  E  +     L 
Sbjct: 952  RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011

Query: 628  NE---VNEKAKKLVEMEREH---EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 681
             E   VN   K  V++E++    E SL + ++++ +LE  K KL   +K  +   +   L
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD--L 1069

Query: 682  EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 741
            E    +L +++ +   +   L   IE        L+++   L   ++     L+     +
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129

Query: 742  KSHDAIIDDLNRKLLDVTQKYTE------------KKLEMEKLLLENDSLSKDVSRLETV 789
               + +  DL+R+L +++++  E            KK E E   +  D     +    T 
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189

Query: 790  FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 849
                +KH   +  L   I  L++   +L+K+  E + ++  +TS    + K  +N     
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL---- 1245

Query: 850  KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 909
               E++  TL D + +   +  + ++   D+  +  K++ +N  L R L+  +  I    
Sbjct: 1246 ---EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302

Query: 910  ISLAEHEAKMSSLSQSMR---KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQE 966
                 +  ++  L + +    K +++ A  L + R   + +   + E    K EL  +  
Sbjct: 1303 RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362

Query: 967  CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1026
                + A   +  E +   + TE EL++   +  Q+   +EE V+    +   L+K    
Sbjct: 1363 KANSEVAQWRTKYETDA-IQRTE-ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ ++ D  V +E+S+    AL +K    +K L +  QKY E ++  E   +E    ++E
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480

Query: 1087 ILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ 1146
            +  ++N  ++    LE +E  K+      +NL+EE+  +        +T+ +L ++ +  
Sbjct: 1481 LFKLKNAYEES---LEHLETFKRE----NKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533

Query: 1147 KNSSVPLAEHLQIKEA-----------FEKEVGIIKASLREKEEESQNKMEEVSK----- 1190
            +   + L   L+  EA            + E   IKA +  K  E   +ME+  +     
Sbjct: 1534 EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593

Query: 1191 -------LQSEVQNTKQAL---KKLE---TREVVDLSKYKATKSDLETQISSLNEKLAN- 1236
                   L +E ++  +AL   KK+E       + LS      ++ + Q+ SL   L + 
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653

Query: 1237 ---------------------------LNRKYEE---VCEEVLHAKK---KEISAKDEKE 1263
                                       L  + EE   V E+   ++K   +E+    E+ 
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713

Query: 1264 LLHFSIEQEIKDQKERCDKSLTTI-TELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322
             L  S    + +QK++ D  L+ + TE++  +QE     E     IT+     E LK+  
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773

Query: 1323 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ-QLADADRQHQEVIAIYR 1372
            +  + L        K   Q I  LQH++   EQ  L    +Q Q++ A  R
Sbjct: 1774 DTSAHLE----RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820



 Score =  142 bits (358), Expect = 2e-33
 Identities = 228/1069 (21%), Positives = 457/1069 (42%), Gaps = 165/1069 (15%)

Query: 267  MQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN--EEVMV 324
            M  E+  K  + E +   +L+ + +DL+  L K+++E+    +KV  L  ++   +E++ 
Sbjct: 932  MNAELTAKKRKLEDE-CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990

Query: 325  A----------------DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHL 368
                             DDL++E +K+ +L  AK K  E+ +  +E    + K    D  
Sbjct: 991  KLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL-EQQVDDLEGSLEQEKKVRMD-- 1047

Query: 369  GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSM-LRPL------ELSLPSQT 421
                  + RK +  LK  Q  + D +     +   ++ +   L  L      E +L SQ 
Sbjct: 1048 ---LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104

Query: 422  SYSENEI------LKKELEAMRTF---CESAKQDRLKLQNELAHKVAEC----------- 461
                 E+      L++ELEA RT     E  + D  +   E++ ++ E            
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164

Query: 462  KALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASG 521
            K    E ++++ D +E   Q E     ++K+  +S  ++ +   +   +K+ L  E +  
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224

Query: 522  NHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 581
               L +   +  + +K K          L +Q+ ++    EE +R    L  +  +LQ E
Sbjct: 1225 KLELDDVTSNMEQIIKAK-ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283

Query: 582  LSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFENMKSSLSNEVNEK------- 633
                     +  R++ E E    +L+  KL  +   ++ E++K  L  EV  K       
Sbjct: 1284 -------NGELSRQLDEKEALISQLTRGKLTYT---QQLEDLKRQLEEEVKAKNALAHAL 1333

Query: 634  --AKKLVEMEREHEKSLSEIR-QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGK 690
              A+   ++ RE  +  +E + +L+R L    +++AQ     E + +     Q++ EL +
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI-----QRTEELEE 1388

Query: 691  KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDD 750
               +L  + Q  ++ +E V      L++  H L  E+++  V ++ S     + D    +
Sbjct: 1389 AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1448

Query: 751  LNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVEL 810
             ++ L +  QKY E + E+E    E  SLS ++ +L+  +   E+  + +   K     L
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY---EESLEHLETFKRENKNL 1505

Query: 811  KKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNREL 870
            ++++S+L ++ G   + IH L      L              E  KM L   L +    L
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQL--------------EAEKMELQSALEEAEASL 1551

Query: 871  LDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI-SLAEHEAKMSSLSQSMRKV 929
                              ++ +IL+  LE   NQIKAE    LAE + +M    ++  +V
Sbjct: 1552 EH----------------EEGKILRAQLEF--NQIKAEIERKLAEKDEEMEQAKRNHLRV 1593

Query: 930  QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATE 989
             DS    L    + + E + +  +++    E++     I++ +A  ++  E +++ K+ +
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEME-----IQLSHANRMA-AEAQKQVKSLQ 1647

Query: 990  KELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--------KTVLI 1038
              LKD   QL +  +     +E +   ++ N+ L+ E+  L+  +          +  LI
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707

Query: 1039 EKSHEMERALSRKTDELNKQLK---DLSQKYTEVKNVKEKL--VEENAKQT-SEILAVQN 1092
            E S  ++   S+ T  +N++ K   DLSQ  TEV+   ++    EE AK+  ++   +  
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767

Query: 1093 LLQKQHVPLEQVEALKKSLNGTIENLKEEL--------KSMQRCYEKEQQTVTKLHQLLE 1144
             L+K+      +E +KK++  TI++L+  L        K  ++  +K +  V +L   LE
Sbjct: 1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827

Query: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQA 1201
             ++  +    + ++  E   KE+        + EE+ +N +   + V KLQ +V+  K+ 
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTY------QTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1881

Query: 1202 LKKLETREVVDLSKYKATKSDL----------ETQISSLNEKLANLNRK 1240
             ++ E +   +LSK++  + +L          E+Q++ L  K  ++  K
Sbjct: 1882 AEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930



 Score =  115 bits (287), Expect = 4e-25
 Identities = 178/884 (20%), Positives = 369/884 (41%), Gaps = 93/884 (10%)

Query: 550  LRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK 609
            L    +Q   I+      EG+ I+  K  +K LS  +++  +         G  K     
Sbjct: 714  LYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQY------KFGHTKVFFKA 767

Query: 610  LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHV 669
              L +  E  +   S +   +  +++ ++    E++K L     L     N++A +    
Sbjct: 768  GLLGLLEEMRDERLSRIITRIQAQSRGVLA-RMEYKKLLERRDSLLVIQWNIRAFMGVKN 826

Query: 670  KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 729
             P      K +   KS E  K++  +  +   L++ +EK     K L+E+  +L  E  +
Sbjct: 827  WPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND 886

Query: 730  HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETV 789
              + ++  +D     +   D L +  + +  K  E    M + L + + ++ +++  +  
Sbjct: 887  LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE----MNERLEDEEEMNAELTAKK-- 940

Query: 790  FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 849
                 K E E   LK +I +L+  L++++K+    + K+  LT E   L ++++      
Sbjct: 941  ----RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA------ 990

Query: 850  KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 909
            K  +E K      L + +++ LD  +  ED      K K K E    +LE +  Q K   
Sbjct: 991  KLTKEKK-----ALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVR 1045

Query: 910  ISLAEHEAKMSS----LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 965
            + L   + K+        +S+  +++   ++    +K   E+  L+A I+ ++     +Q
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105

Query: 966  ECIKVKYAPIVSFEE---CERKFKATEKELKDQLSEQTQKYSVSEEEV----KKNKQEND 1018
            + +K   A I   EE    ER  +A  ++L+  LS + ++ S   EE         + N 
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1165

Query: 1019 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVE 1078
            K + E   +++DL + T+     HE   A  RK       + +L ++   ++ VK+KL +
Sbjct: 1166 KREAEFQKMRRDLEEATL----QHEATAAALRKKHA--DSVAELGEQIDNLQRVKQKLEK 1219

Query: 1079 ENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTK 1138
            E ++   E+  V +        +EQ+   K +L      L++++   +   E+ Q++V  
Sbjct: 1220 EKSEFKLELDDVTS-------NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND 1272

Query: 1139 LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNT 1198
            L       +  +  L+  L  KEA   ++   K +  ++ E+ + ++EE  K ++ + + 
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332

Query: 1199 KQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYE----EVCEEVLHAKKK 1254
             Q+ +           +    K++L+  +S  N ++A    KYE    +  EE+  AKKK
Sbjct: 1333 LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392

Query: 1255 -------------EISAK-DEKELLHFSIEQEIKD---QKERCDKSLTTITELQR----- 1292
                          ++AK    E     ++ EI+D     ER + +   + + QR     
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452

Query: 1293 ------RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1346
                  + +ES  ++E+   +   L  ++ +LK A     +   T     KR+++    L
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET----FKRENK---NL 1505

Query: 1347 QHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEA 1390
            Q ++  L +QL  + +   E+  + +   L A +  +   ++EA
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQ--LEAEKMELQSALEEA 1547



 Score =  110 bits (275), Expect = 9e-24
 Identities = 175/852 (20%), Positives = 351/852 (41%), Gaps = 152/852 (17%)

Query: 245  NTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH-QNIQDL--EIEN-EDLKERLRKI 300
            N  +  E  K    L++  L H   E    + +++H  ++ +L  +I+N + +K++L K 
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220

Query: 301  QQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRF 360
            + E ++ LD V     Q+   +    +LE     L+  +     + EE+ R++  L ++ 
Sbjct: 1221 KSEFKLELDDVTSNMEQI---IKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR 1277

Query: 361  KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQ 420
               ++++ G  S   + KE ++          SQ T   +    Q   + R LE  + ++
Sbjct: 1278 AKLQTEN-GELSRQLDEKEALI----------SQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326

Query: 421  TSYSEN-EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQI 479
             + +   +  + + + +R   E   + + +LQ  L+   +E   +A    + + D+ ++ 
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE---VAQWRTKYETDAIQRT 1383

Query: 480  KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDL--- 536
            ++LE+A K + +R+ E+E  V+ +     +L++          HRL  E++D + D+   
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT--------KHRLQNEIEDLMVDVERS 1435

Query: 537  ---------------------KVKYEGA--------------SAEVGKLRNQIKQNEMIV 561
                                 K KYE +              S E+ KL+N  +++   +
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495

Query: 562  EEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN 621
            E FKR       ENK LQ+E+S    +    G+ + E+E   K+L A+            
Sbjct: 1496 ETFKR-------ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE------------ 1536

Query: 622  MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 681
             K  L + + E    L   E +  ++  E  Q+K E+E    KLA+  K EE EQ K   
Sbjct: 1537 -KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAE--KDEEMEQAKRNH 1590

Query: 682  EQKSGELGKKI-TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDM 740
             +    L   +  E   +N+ L+ +        K ++   + + I++ +       ++  
Sbjct: 1591 LRVVDSLQTSLDAETRSRNEALRVK--------KKMEGDLNEMEIQLSHANRMAAEAQKQ 1642

Query: 741  KKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEI 800
             KS  +++ D   +L D  +   + K  +  +   N+ L  ++  L  V    E+  K  
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK-- 1700

Query: 801  IALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNL---KKMMSNQYVPVKTH-EEVK 856
                         L+E  ++  E  E++  L S+NT+L   KK M      ++T  EE  
Sbjct: 1701 -------------LAE--QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1745

Query: 857  MTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK--------AE 908
                +   K  + + D     E++ +E    +D +  L+R  +N +  IK        AE
Sbjct: 1746 QECRNAEEKAKKAITDAAMMAEELKKE----QDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801

Query: 909  YISLA-------EHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL 961
             I+L        + EA++  L   +   Q  NAE +   RK +  I  L  + +  +K L
Sbjct: 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL 1861

Query: 962  DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK 1021
              +Q+ +      +       + +K   +E ++Q +    K+   + E+ + ++  D  +
Sbjct: 1862 LRLQDLVDKLQLKV-------KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1914

Query: 1022 KEIFTLQKDLRD 1033
             ++  L+   RD
Sbjct: 1915 SQVNKLRAKSRD 1926


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  174 bits (440), Expect = 7e-43
 Identities = 266/1267 (20%), Positives = 543/1267 (42%), Gaps = 232/1267 (18%)

Query: 258  SLQQRNLTHMQDEVNVKSHQRE-HQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQL 316
            SL+Q+      +  N+K  +    Q    L  E  D+K +  + +  +     KV  L  
Sbjct: 139  SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198

Query: 317  QLNEEVMVADDLESE-------------REKLKSLLAAKEKQHEESLRTIEALKNRFKYF 363
            +LN+E  V  DL++E             +++L  +    +    E  R  E LK+  K  
Sbjct: 199  ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258

Query: 364  ESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSY 423
            +S +  S +  S  + +  L +G   +A           ++Q    L+     L  +   
Sbjct: 259  QSQYASSEATISQLRSE--LAKGPQEVA----------VYVQELQKLKSSVNELTQKNQT 306

Query: 424  SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLE 483
                +LKKE            QD  KL+                 E+  E+S  +     
Sbjct: 307  LTENLLKKE------------QDYTKLE-----------------EKHNEESVSK----- 332

Query: 484  DALKDVQKRMYESEGKVKQMQTHFLALKE--HLTSEAASGNHRLTEELKDQLKDLKVKYE 541
               K++Q  +++ +   +Q+Q+   A +   H      S     T++LK++L +++ KY+
Sbjct: 333  ---KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQ 389

Query: 542  GASAEVGKLRNQIKQNE----MIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVT 597
               AE  +L+ Q ++ E     +  E  +   KL+E  ++L +     + +R+    K+ 
Sbjct: 390  HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449

Query: 598  EMEGQAKELSAKLA-LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR 656
            + E Q  +L  KL+ L    ++     + L +++++  ++  E +   + + +++R+ + 
Sbjct: 450  DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509

Query: 657  ELENV-------------------KAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTL 697
            +LE V                   K+K    +  +E E + ++++   GE    + +L  
Sbjct: 510  DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA-VLNQLQE 568

Query: 698  KNQTLQKEI----EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR 753
            KN TLQ+++    EK+   ++  K+   NL  +++     L+ ++D   S +  +++LN 
Sbjct: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628

Query: 754  KLLDVTQKYTEKKLEME---KLLL--------------------------ENDSLSKDVS 784
            +L +  +K ++  ++++   +LLL                          +   L+K  +
Sbjct: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688

Query: 785  RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 844
            +L+ V    +  ++    L+S++ E K++   L++K  E + +I  L +++  +K     
Sbjct: 689  QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748

Query: 845  QYVPVKTHEEVKMTLNDTLAKTNREL-----------LDVKKK---FEDINQEFVKIKDK 890
                ++   ++   L     + +++L           LD++KK    E I Q+  K +++
Sbjct: 749  ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808

Query: 891  NEILKRNLENTQNQIKAEYISL---------------AEHEAKMSSLS---QSMRKVQD- 931
             +ILK++ E    + K ++  L                E EA M+ LS     + KV D 
Sbjct: 809  KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868

Query: 932  ---SNAEILANYRKGQEEIVTLHAEIKAQKKEL-----DTIQECIKVKYAPIVSFEECER 983
               S +E     +KG+  I+ L    K  K +L     +T++E  ++K + +   +E   
Sbjct: 869  LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS-LEKEKEASH 927

Query: 984  KFKATEKELKDQL--SEQTQKYSVSEEE-----VKKNKQENDKLKKEIFTLQKDLRDKTV 1036
            + K     +++QL  ++ T K +  EE+     + + KQ +++ KK+I  LQ +L  K  
Sbjct: 928  QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL--KIA 985

Query: 1037 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ--------TSEIL 1088
            +++K+ E+E  L ++  +  ++L    +K + ++N  EK  +E  KQ         SE+L
Sbjct: 986  VLQKT-ELENKLQQQLTQAAQELAAEKEKISVLQNNYEK-SQETFKQLQSDFYGRESELL 1043

Query: 1089 AVQNLLQ--KQHVPLEQVEAL-KKSLNGTIENLKEELKSMQRCYE-----KEQQTVTKLH 1140
            A +  L+  ++ + L Q + +  ++  G    L +ELK+ +   E     KEQQ   +  
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103

Query: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
             L + QK  S+            EKE+   K+ L E EE    + +E++KL  E+++   
Sbjct: 1104 ALQDIQKEKSLK-----------EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS--- 1149

Query: 1201 ALKKLET-REVVDLSKYK----ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK--- 1252
               KLE+ +E+ +L   K      K +L+ +  SL   +    R  + + ++V   +   
Sbjct: 1150 --HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207

Query: 1253 KKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1309
            KKE   K+ K  LH  I+++   +K  +E   K    IT L   +    K+ ++   +++
Sbjct: 1208 KKEFIEKEAK--LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1265

Query: 1310 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL---------IDTLQHQVKSLEQQLADA 1360
            EL    + L+  +  L        N  +R++ L         I+ LQ +V  L+++L + 
Sbjct: 1266 ELEKQTDDLRGEIAVLE--ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT 1323

Query: 1361 DRQHQEV 1367
                QE+
Sbjct: 1324 TAAVQEL 1330



 Score =  169 bits (427), Expect = 2e-41
 Identities = 220/1119 (19%), Positives = 495/1119 (44%), Gaps = 123/1119 (10%)

Query: 271  VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVN-------GLQLQLNEEVM 323
            V V+  Q+   ++ +L  +N+ L E L K +Q+   L +K N        +Q  L+++ +
Sbjct: 285  VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344

Query: 324  VADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLL 383
                L+S     ++ L     +  E     + LK      E+ +    + F   ++    
Sbjct: 345  DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404

Query: 384  KQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKE-----LEAMRT 438
            K+       S+         +++   L      L  Q   S  +++ KE     L+   +
Sbjct: 405  KEQHGLQLQSEINQLHSKL-LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463

Query: 439  FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 498
              E   ++++    EL H++ + K    E + +++ +  ++++ ++ L+ V +++ + + 
Sbjct: 464  RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523

Query: 499  KVKQMQTHFLALKEHLTS------------EAASGNHRLTEELKDQLKDLKVKYEGASAE 546
            K++ ++      KE+++             +A  G   +  +L+++   L+   E  +  
Sbjct: 524  KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ---EQVTQL 580

Query: 547  VGKLRNQIKQN----EMIVEEFKRDEGKL-IEENKRLQKELSMCEMERE--KKGRKVTEM 599
              KL+NQ + +    E + ++ +  +  L   +++ L  E S+ E+  +  +   KV+++
Sbjct: 581  TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640

Query: 600  EGQAKELSAKLALSIPAEKFEN-MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 658
            + Q K   AK  L + AE  +   ++ L N ++     L + ++E  K  +++ Q+  +L
Sbjct: 641  DIQIK---AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697

Query: 659  ENVK---AKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 715
            ++ +   ++L  H+K  E+++    LEQK+ EL  +I +L   +  ++   E+   D + 
Sbjct: 698  QDKQEHCSQLESHLK--EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755

Query: 716  LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 775
             ++   +L +        L++ +++  S    +   +  L  + QK T+++ E + L  +
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 776  NDSLSKDV--------SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK 827
             ++LS++         +R++T     +K + E  AL + +  +K +LS++       + +
Sbjct: 816  FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875

Query: 828  IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI 887
                  EN   K  + +     KT +E+K  L   +  T +E  ++KK  E       K 
Sbjct: 876  FE---KENQKGKAAILDLE---KTCKELKHQLQVQMENTLKEQKELKKSLE-------KE 922

Query: 888  KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 947
            K+ +  LK  L + Q Q+     +L ++E +   L  ++ +++ S+ +            
Sbjct: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ------------ 970

Query: 948  VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE 1007
                     +KK+++ +Q  +K+    ++   E E K +    +   +L+ + +K SV +
Sbjct: 971  ---------KKKQIEALQGELKIA---VLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018

Query: 1008 EEVKKNKQENDKLKKEIFTLQKDL----------RDKTVLIEKSHEMERALSRKTDELNK 1057
               +K+++   +L+ + +  + +L           +K  L ++     R      ++L +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078

Query: 1058 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHV----PLEQVEALKKSLNG 1113
            +LK       +    KE+ ++E  K   +I   ++L +K+ V     L ++E +K     
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138

Query: 1114 TIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKA 1172
             I  L EELKS +    KE   +    QLL  QK      A+ L+   E  ++   I+K 
Sbjct: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD 1198

Query: 1173 SLREKEEESQNK-MEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1231
             ++++EEE + + +E+ +KL SE++  +  +KK E  E           + L  QI++LN
Sbjct: 1199 QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE-----------AKLTMQITALN 1247

Query: 1232 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK---ERCDKSLTTIT 1288
            E L  + ++++     V   +K+    + E  +L  +++    +++   ERC K    I 
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307

Query: 1289 ELQRRIQESAKQIEAKDNKITELLNDVERLK----QALN 1323
            +LQ ++ E  ++++     + EL  + + L+    QALN
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346



 Score =  162 bits (409), Expect = 3e-39
 Identities = 234/1124 (20%), Positives = 498/1124 (44%), Gaps = 177/1124 (15%)

Query: 327  DLESEREKLKSLLAAKEKQHE-----ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDM 381
            DL+S    + ++    E   E     + ++++ +    FK++E+ H          + ++
Sbjct: 19   DLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNL 78

Query: 382  LLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCE 441
             LK+  + +                R  ++ L+ SL  +  YSE   LKKELE      +
Sbjct: 79   ALKRDDVTLL---------------RQEVQDLQASLKEEKWYSEE--LKKELEKY----Q 117

Query: 442  SAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVK 501
              +Q   K    +    AE ++L  + E  + ++   IKQ++D  +    ++      +K
Sbjct: 118  GLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN-IKQMKDLFEQKAAQLATEIADIK 176

Query: 502  QMQTHFLALKEHLTSEAASGNHRLTEELKDQ---LKDLKVKY--EGASAEVGKLRNQIKQ 556
                   +L+E    +      RLTEEL  +   ++DLK +        +V  L+ ++ Q
Sbjct: 177  SKYDEERSLREAAEQKVT----RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232

Query: 557  NEMIVE----EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 612
             + +++    E +R+  KL +E K+LQ + +  E         ++++  +  +   ++A+
Sbjct: 233  VQTLMDNMTLERERESEKLKDECKKLQSQYASSEAT-------ISQLRSELAKGPQEVAV 285

Query: 613  SIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ---HV 669
             +  ++ + +KSS+ NE+ +K + L E   + E+  +++ +   E E+V  K  Q   H 
Sbjct: 286  YV--QELQKLKSSV-NELTQKNQTLTENLLKKEQDYTKLEEKHNE-ESVSKKNIQATLHQ 341

Query: 670  KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQK------EIEKVY---------LDNK 714
            K  + +Q++SRL      L +   EL+ K +  QK      E+E  Y         L  +
Sbjct: 342  KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401

Query: 715  LLKEQAHNLTIEMKNHYVPLKVSE---DMKKSHDAIIDDL---NRKLLDVTQKYTEKKLE 768
              +++ H L ++ + + +  K+ E    + ++H  + +     + KL+D  Q+  + +L+
Sbjct: 402  REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461

Query: 769  MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV----ELKKQLSELKKKCGED 824
            + +L  +      + + L+      ++  +E  AL+ +      E +  L ++ ++ G+ 
Sbjct: 462  LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521

Query: 825  QEKIHAL------TSENTNL-KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 877
             +KI  L      + EN +L +K   + Y  ++  E     LN  L + N  L       
Sbjct: 522  DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQ------ 574

Query: 878  EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 937
            E + Q   K+K+++E  K+  EN  +Q++ +   L   + ++ SL  S+        E+ 
Sbjct: 575  EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN-------ELN 627

Query: 938  ANYRKGQEEIVTLHAEIKAQ------------------KKELDTIQECIKVKYAPI---- 975
            +   + +E++  L  +IKA+                  +  LDT Q  ++ K   +    
Sbjct: 628  SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687

Query: 976  VSFEECERKFKATEK---ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLR 1032
               ++   K +  ++   +L+  L E  +KY   E++ ++ + +  KL+ +   ++    
Sbjct: 688  TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747

Query: 1033 DKTVLIEKSHEMERALSRKTDELNKQLK-----------DLSQKYTEVKNVKEKLVEENA 1081
                 +++  ++   L  +  EL+KQL+           DL +K   ++++K+KL ++  
Sbjct: 748  QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807

Query: 1082 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-KLH 1140
            ++       + L Q+  +   Q E L   +  T+  L +++K  +     E  TV  KL 
Sbjct: 808  EKQILKQDFETLSQETKI---QHEELNNRIQTTVTEL-QKVKMEKEALMTELSTVKDKLS 863

Query: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
            ++ ++ KNS          K  FEKE    KA++ + E+  +   E   +LQ +++NT +
Sbjct: 864  KVSDSLKNS----------KSEFEKENQKGKAAILDLEKTCK---ELKHQLQVQMENTLK 910

Query: 1201 ALKKLETREVVDLSKYKATKSDLETQISSLNEKL--ANLNRKYEEVCEEVLHAKKKEISA 1258
              K+L+      L K K     L+ +++S+ E+L  A    K  E  E+ L     E+  
Sbjct: 911  EQKELKK----SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966

Query: 1259 KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQ----ESAKQIEAKDNKITELLND 1314
              E++      +++I+  +     ++   TEL+ ++Q    ++A+++ A+  KI+ L N+
Sbjct: 967  SSEQK------KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 1315 VERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1358
             E+ ++    L    Y       R+S+L+ T Q  +KS+E++L+
Sbjct: 1021 YEKSQETFKQLQSDFY------GRESELLATRQ-DLKSVEEKLS 1057



 Score =  125 bits (314), Expect = 3e-28
 Identities = 185/918 (20%), Positives = 383/918 (41%), Gaps = 93/918 (10%)

Query: 263  NLTHMQDEVN-VKSHQREHQNIQD-----LEIENEDLKERLRKIQQEQRILLDKVNGLQL 316
            N T +Q +++  K   +E Q +Q      L     DL++ LR+I  + +    K+  L+ 
Sbjct: 475  NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ----KIQNLEA 530

Query: 317  QLNEEVMVADDLESEREKLKSLLAA-----------KEKQH---EESLRTIEALKNRFKY 362
             L +       LE ERE L + + A           +EK H   E+  +  E LKN+ + 
Sbjct: 531  LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590

Query: 363  FESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTS 422
             +            +K  +   Q ++   ++         + +S+  +  L++ + ++T 
Sbjct: 591  HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN-ESKEKVSQLDIQIKAKTE 649

Query: 423  YSENEILKKELEAMRTFCESAKQDRLKL-QNELAHKVAECKALALECERVK---EDSDEQ 478
                  L    EA +T   +  Q+ L   QN L  K  E   +  + ++V    +D  E 
Sbjct: 650  ------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703

Query: 479  IKQLEDALKD-------VQKRMYESEGKVKQMQTHFLALK--EHLTSEAASGNHRLTEEL 529
              QLE  LK+       ++++  E EG++K+++   L +K  +    +      +L  +L
Sbjct: 704  CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763

Query: 530  KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMER 589
            + +  +L  + E     V   R  +++    +E  K+   K  EE + L+++      E 
Sbjct: 764  ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823

Query: 590  EKKGRK--------VTEMEGQAKELSAKLA-LSIPAEKFENMKSSLSNEVNEKAKKLVEM 640
            + +  +        VTE++    E  A +  LS   +K   +  SL N  +E        
Sbjct: 824  KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE-------F 876

Query: 641  EREHEKSLSEIRQLKRELENVKAKLA---QHVKPEEHEQVKSRLEQKSGELGKKITELTL 697
            E+E++K  + I  L++  + +K +L    ++   E+ E  KS  ++K      K+   ++
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSM 936

Query: 698  KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLD 757
            + Q +Q +       N+  ++Q      E+K        SE  KK  +A+  +L   +L 
Sbjct: 937  QEQLIQAQ--NTLKQNEKEEQQLQGNINELKQS------SEQKKKQIEALQGELKIAVLQ 988

Query: 758  VTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSEL 817
             T+   E KL+ ++L      L+ +  ++  +    EK ++    L+S+    + +L   
Sbjct: 989  KTE--LENKLQ-QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045

Query: 818  KKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKF 877
            ++     +EK+     +  + +  + NQ   ++  +  K TL    AK  ++L +  K  
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKAL 1105

Query: 878  EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 937
            +DI +E   +K+K  + +++      +IK         E +++ L++ ++  +  + + +
Sbjct: 1106 QDIQKE-KSLKEKELVNEKSKLAEIEEIKCR------QEKEITKLNEELKSHKLESIKEI 1158

Query: 938  ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 997
             N +  ++ ++    E++ +   L    E  K     +      + + K  E+ELK +  
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL------KDQVKKEEEELKKEFI 1212

Query: 998  EQTQKY--SVSEEEV--KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1053
            E+  K    + E+EV  KK+++   KL  +I  L ++L       + S      L ++TD
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272

Query: 1054 ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1113
            +L  ++  L       ++ +  L+E   K   EI  +Q  + +    L+   A  + L  
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332

Query: 1114 TIENLKEELKSMQRCYEK 1131
              EN   ++K  Q    K
Sbjct: 1333 --ENQSLQIKHTQALNRK 1348



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 103/454 (22%), Positives = 211/454 (46%), Gaps = 42/454 (9%)

Query: 239  LKTASENTNKGRELWKKGPSLQQRNLTHMQDEV--NVKSHQREHQNIQDLEIENEDLKER 296
            LK + E   +     K   +  Q  L   Q+ +  N K  Q+   NI +L+  +E  K++
Sbjct: 915  LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974

Query: 297  LRKIQQEQRILLDKVNGLQLQLNEEV-MVADDLESEREKLKSLLAAKEKQHEESLRTIEA 355
            +  +Q E +I + +   L+ +L +++   A +L +E+EK+  L    EK  E        
Sbjct: 975  IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET------- 1027

Query: 356  LKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLEL 415
                FK  +SD  G  S     ++D+   + ++ +A     S       Q++     L  
Sbjct: 1028 ----FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-----LIQ 1078

Query: 416  SLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS 475
             L +  +  E +  KKE + ++  C+ A QD  K ++    ++   K+   E E +K   
Sbjct: 1079 ELKTAKATLEQDSAKKE-QQLQERCK-ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136

Query: 476  DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE------L 529
            +++I +L + LK  +    +    +K  +   +  K  L  +A S    + +E      L
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196

Query: 530  KDQLK--DLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM 587
            KDQ+K  + ++K E    E  KL ++IK+ E+ +++ + +E KL  +   L + L   + 
Sbjct: 1197 KDQVKKEEEELKKEFIEKEA-KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255

Query: 588  EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEK---AKKLVEMEREH 644
            E +   R+V+E+E Q  +L  ++A+         +++++ N  +E+    ++ ++ E E 
Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIAV---------LEATVQNNQDERRALLERCLKGEGEI 1306

Query: 645  EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVK 678
            EK  +++ +L+R+L+N  A + +  +  +  Q+K
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 78/393 (19%), Positives = 170/393 (43%), Gaps = 47/393 (11%)

Query: 1033 DKTVLIEKSHEMERALSRK---TDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1089
            D T+L ++  +++ +L  +   ++EL K+L    +KY  ++  + K        ++E+ +
Sbjct: 84   DVTLLRQEVQDLQASLKEEKWYSEELKKEL----EKYQGLQQQEAKPDGLVTDSSAELQS 139

Query: 1090 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKE-------QQTVTKLHQL 1142
            ++  L++       ++ +K         L  E+  ++  Y++E       +Q VT+L + 
Sbjct: 140  LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199

Query: 1143 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASL-----------REKEEESQNKMEEVSKL 1191
            L  +      L   L  +   E +V ++K  L            E+E ES+   +E  KL
Sbjct: 200  LNKEATVIQDLKTELLQRPGIE-DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258

Query: 1192 QSEVQNTKQALKKLETR----------EVVDLSKYKATKSDLETQISSLNEKLANLNRKY 1241
            QS+  +++  + +L +            V +L K K++ ++L  +  +L E L    + Y
Sbjct: 259  QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318

Query: 1242 EEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQI 1301
             ++ E+     ++ +S K+ +  LH   + + +  + R   S T++  +   + E  +  
Sbjct: 319  TKLEEK---HNEESVSKKNIQATLHQK-DLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374

Query: 1302 EAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADAD 1361
            +    +++E+    + LK     L Q         K Q  L   LQ ++  L  +L + +
Sbjct: 375  QKLKEELSEVETKYQHLKAEFKQLQQQ-----REEKEQHGL--QLQSEINQLHSKLLETE 427

Query: 1362 RQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQI 1394
            RQ  E     +     +++  MD++ Q A LQ+
Sbjct: 428  RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  172 bits (435), Expect = 3e-42
 Identities = 245/1056 (23%), Positives = 470/1056 (44%), Gaps = 157/1056 (14%)

Query: 430  KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
            K +LEA         +D  ++  EL    A+ + L  EC  +K+D D+    LE  L  V
Sbjct: 913  KFQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 965

Query: 490  QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV---KYEGASAE 546
            +K  + +E KVK +      L E + ++       L E  +  L DL+    K    +  
Sbjct: 966  EKEKHATENKVKNLTEELSGLDETI-AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
              KL  Q++  E  +E+ K+    L    ++L+ +L + +         + ++E   ++L
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-------ESILDLENDKQQL 1077

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
              +L      +K +     L ++V ++    ++ +++ ++  + I +L+ E+E  +A  A
Sbjct: 1078 DERL------KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA 1131

Query: 667  QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 704
            +  K       E E++  RLE+  G      EL KK           + E TL+++ +  
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191

Query: 705  EIEKVYLDNKL-LKEQAHNLT-----IEMKNHYVPLKVSEDMKKSHDAI------IDDLN 752
             + K + D+   L EQ  NL      +E +     L++ +D+  S +++      ++ + 
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI-DDLSSSMESVSKSKANLEKIC 1250

Query: 753  RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF--VPPEKHEKEIIA--LKSNIV 808
            R L D   +   K  E+++ L E   L+   SRL+T    +  +  EKE I   L  +  
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSE---LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307

Query: 809  ELKKQLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 864
               +Q  ELK++  E+ +      HAL S   +   ++  QY   +  +E K  L   L+
Sbjct: 1308 AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD-LLREQY---EEEQEGKAELQRALS 1363

Query: 865  KTNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEA------ 917
            K N E+   + K+E D  Q   ++++  + L + L++++ Q++A     A  E       
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423

Query: 918  -----------KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ- 965
                       + +SL+ ++ K Q +  ++LA ++   EE     AE++A  KE  ++  
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES---QAELEASLKESRSLST 1480

Query: 966  ECIKVKYA---PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKK 1022
            E  K+K A    +   E  +R+ K  E+E+ D L+EQ  +   +  E++K++++ +  K 
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIAD-LTEQIAENGKTIHELEKSRKQIELEKA 1539

Query: 1023 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1082
            +I   Q  L +    +E  HE E  + R   EL +   ++ +K  E     E+L + N +
Sbjct: 1540 DI---QLALEEAEAALE--HE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQL-KRNYQ 1592

Query: 1083 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1142
            +T E +  Q+ L  +     +   LKK + G +  ++ +L    R   +  +T+  L  +
Sbjct: 1593 RTVETM--QSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR---QAAETLKHLRSV 1647

Query: 1143 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQAL 1202
                K++ + L + L+ +E  ++++ I+       E  +     EV +L++ ++ T++A 
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIV-------ERRANLLQAEVEELRATLEQTERA- 1699

Query: 1203 KKLETREVVDLSKYKA-----------TKSDLETQISSLNEKLANLNRKYEEVCEEVLHA 1251
            +KL  +E++D ++              TK  LET +  L  ++ + +R      E+   A
Sbjct: 1700 RKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKA 1759

Query: 1252 ----------KKKEISAKDEKELLHFSIEQEIKDQKERCDKS--------LTTITELQRR 1293
                       KKE       E +  ++EQ +KD + R D++           I +L+ R
Sbjct: 1760 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETR 1819

Query: 1294 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK---RQSQLIDTLQHQV 1350
            I+E   ++E +  K TE    V+ L++    + +LTY S    K   R   L+D LQ +V
Sbjct: 1820 IRELEFELEGEQKKNTE---SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1876

Query: 1351 KSLEQQLADADRQHQEVIAIYR--THLLSAAQGHMD 1384
            KS ++Q  +AD Q    +  +R   H L  A+   D
Sbjct: 1877 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERAD 1912



 Score =  141 bits (356), Expect = 4e-33
 Identities = 189/896 (21%), Positives = 395/896 (44%), Gaps = 114/896 (12%)

Query: 570  KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 629
            K + ++   +KE++  + E +K   ++ + E + KEL  KL   +        K+ L  +
Sbjct: 838  KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLV------QEKNDLQLQ 891

Query: 630  VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 689
            V  +++ L++ E   ++ +    QL+ +++ V        + E+ E++ + L  K  +L 
Sbjct: 892  VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE------RAEDEEEINAELTAKKRKLE 945

Query: 690  KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL----KVSEDMKKSHD 745
             + +EL      L+  + KV  +    + +  NLT E+      +    +  + ++++H 
Sbjct: 946  DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ 1005

Query: 746  AIIDDLNRK-----LLDVTQKYTEKKLE-MEKLLLENDSLSKDVSRLETVFVPPEKHEKE 799
              +DDL  +      L+ T+   E+++E +E  L +   L  D+ R +       K E +
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK------RKLEGD 1059

Query: 800  IIALKSNIVEL---KKQLSE-LKKKCGED---QEKIHALTSENTNLKKMMSNQYVPVKTH 852
            +   + +I++L   K+QL E LKKK  E    Q K+    +     +K +      ++  
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119

Query: 853  EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 912
            EE       T AKT ++  D  ++ E++++   ++++   +    +E  + + +AE++ L
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSE---RLEEAGGVTSTQIELNKKR-EAEFLKL 1175

Query: 913  --------AEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKAQKKEL 961
                     +HEA +++L    +K  DS AE+   + N ++ ++++    +E K +  +L
Sbjct: 1176 RRDLEEATLQHEAMVAAL---RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL 1232

Query: 962  DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLK 1021
             +  E          S  + +   +   + L+DQLSE   K    +  + +   +  +L+
Sbjct: 1233 SSSME----------SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ 1282

Query: 1022 KEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-------------------- 1061
             E   L + L +K  ++ +    ++A +++T+EL +QL++                    
Sbjct: 1283 TEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342

Query: 1062 -LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-LEQVEALKKSLNGTIENLK 1119
             L ++Y E +  K +L    +K  SE+   +   +   +   E++E  KK L   +++ +
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE 1402

Query: 1120 EELKSMQRCYEKEQQTVTKLHQLLEN---QKNSSVPLAEHLQIKEA-FEKEVGIIKASLR 1175
            E+++++       ++T  +L   +E+       +  LA  L  K+  F+K +   K    
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462

Query: 1176 EKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-LSKYKATKSDLETQISSLNEKL 1234
            E + E +  ++E   L +E+   K A +     E +D L   K    +LE +I+ L E++
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYE-----EALDQLETVKRENKNLEQEIADLTEQI 1517

Query: 1235 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1294
            A   +   E     L   +K+I    EK  +  ++E+     +    K L    EL +  
Sbjct: 1518 AENGKTIHE-----LEKSRKQIEL--EKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570

Query: 1295 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLE 1354
             E  ++I  KD +I +L  + +R  + +         S N   R   L   ++  +  +E
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR---LKKKMEGDLNEIE 1627

Query: 1355 QQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQEALLQIIQMRQGLV 1402
             QL+ A+RQ  E +   R+    L   Q H+D      ED++E  L I++ R  L+
Sbjct: 1628 IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ-LAIVERRANLL 1682



 Score =  141 bits (355), Expect = 5e-33
 Identities = 205/991 (20%), Positives = 423/991 (42%), Gaps = 147/991 (14%)

Query: 258  SLQQRNLTHMQDEVNVKSHQRE----HQNIQDLEIENEDLKERLRKIQQEQRILLDKVN- 312
            SL+Q     +  E N +  + +     ++I DLE + + L ERL+K   E   L  KV  
Sbjct: 1038 SLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED 1097

Query: 313  ----GLQLQLNEEVMVA--DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESD 366
                GLQ Q   + + A  ++LE E E  ++  A  EKQ  +  R +E L  R +  E+ 
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE--EAG 1155

Query: 367  HLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSEN 426
             + S     N+K +                                           +E 
Sbjct: 1156 GVTSTQIELNKKRE-------------------------------------------AEF 1172

Query: 427  EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL 486
              L+++LE      E+       L+ + A  VAE        +RVK+  +++  + +  +
Sbjct: 1173 LKLRRDLEEATLQHEAMVA---ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229

Query: 487  KDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAE 546
             D+   M ES  K K          E   SEA   N    EE++  L +L  +      E
Sbjct: 1230 DDLSSSM-ESVSKSKANLEKICRTLEDQLSEARGKN----EEIQRSLSELTTQKSRLQTE 1284

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
             G+L  Q+++ E IV +  R +    ++ + L+++L     E E K +       Q+   
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL-----EEENKAKNALAHALQSSRH 1339

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
               L L    E+ +  K+ L   +++   ++ +   ++E   ++  Q   ELE  K KLA
Sbjct: 1340 DCDL-LREQYEEEQEGKAELQRALSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKLA 1395

Query: 667  QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 726
            Q ++  E EQV++        +  K   L    Q LQ E+E + +D     E+A++L   
Sbjct: 1396 QRLQDSE-EQVEA--------VNAKCASLEKTKQRLQGEVEDLMVD----VERANSLAAA 1442

Query: 727  MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
            +           D K+ +       ++ L +   K  E + E+E  L E+ SLS ++ +L
Sbjct: 1443 L-----------DKKQRN------FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485

Query: 787  ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 846
            +  +   E+   ++  +K     L++++++L ++  E+ + IH L      ++   ++  
Sbjct: 1486 KNAY---EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542

Query: 847  VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK 906
            + +   EE +  L    AK  R  L++ +   +I+++  +  ++ E LKRN + T   ++
Sbjct: 1543 LAL---EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599

Query: 907  AEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQK--KELDTI 964
            +        +A++ S ++++R  +    ++       + EI   HA  +A +  K L ++
Sbjct: 1600 SAL------DAEVRSRNEAIRLKKKMEGDL------NEIEIQLSHANRQAAETLKHLRSV 1647

Query: 965  QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI 1024
            Q  +K      +  ++  R     +++LK+QL+   ++ ++ + EV++ +   ++ ++  
Sbjct: 1648 QGQLKDTQ---LHLDDALRG----QEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700

Query: 1025 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1084
               +++L D    ++  H    +L     +L   L  L  +  +         E+  K  
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE--------LKSMQRCYEKEQQTV 1136
            ++   +   L+K+      +E +KK+L  T+++L+          LK  ++  +K +  +
Sbjct: 1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820

Query: 1137 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQS 1193
             +L   LE ++  +    + L+  E   KE+        + EE+ +N +   + V KLQ 
Sbjct: 1821 RELEFELEGEQKKNTESVKGLRKYERRVKEL------TYQSEEDRKNVLRLQDLVDKLQV 1874

Query: 1194 EVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
            +V++ K+  ++ + +    L+K++  + +LE
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 84/419 (20%), Positives = 193/419 (46%), Gaps = 53/419 (12%)

Query: 964  IQECIKVKYAPIVS-FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKK 1022
            I+  + VK+ P +  F + +   K+ E E   +++   +++  +++E+ K++ +  +L++
Sbjct: 819  IRSFMNVKHWPWMKLFFKIKPLLKSAETE--KEMATMKEEFQKTKDELAKSEAKRKELEE 876

Query: 1023 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK-------QLKDLSQKYTEVKNVKEK 1075
            ++ TL ++  D  + ++   E       + D+L K       ++K+++++  + + +  +
Sbjct: 877  KLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAE 936

Query: 1076 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1135
            L  +  K   E   ++  +    + L +VE  K +    ++NL EEL  +        +T
Sbjct: 937  LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD-------ET 989

Query: 1136 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1195
            + KL +  +  + +     + LQ +E     +   K+ L ++ E+ ++ +E+  KL+ ++
Sbjct: 990  IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049

Query: 1196 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1255
            +  K+ L+        DL   + +  DLE     L+E+L   + +Y ++  +V       
Sbjct: 1050 ERNKRKLEG-------DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV------- 1095

Query: 1256 ISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV 1315
                ++++ L    +++IK              ELQ RI+E  ++IEA+  + T    + 
Sbjct: 1096 ----EDEQTLGLQFQKKIK--------------ELQARIEELEEEIEAE--RATRAKTEK 1135

Query: 1316 ERLKQA--LNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
            +R   A  L  LS+    +G  T  Q +L    + +   L + L +A  QH+ ++A  R
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 69/374 (18%), Positives = 161/374 (43%), Gaps = 37/374 (9%)

Query: 261  QRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNE 320
            Q  LT ++ E++ K  +++           E++++  R  Q+    +   ++      NE
Sbjct: 1563 QLELTQVKSEIDRKIAEKD-----------EEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611

Query: 321  EVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK--YFESDHLGSGSHFSNRK 378
             + +   +E +  +++  L+   +Q  E+L+ + +++ + K      D    G      +
Sbjct: 1612 AIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671

Query: 379  EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP--LELSLPSQTSYSENEIL---KKEL 433
              ++ ++  +  A+ +     +    ++R +     L+ +   Q  +++N  L   KK+L
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731

Query: 434  EA----MRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS---DEQIKQLEDAL 486
            E     +++  E A +D    + +    + +   +A E ++ ++ S   +   K LE  +
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791

Query: 487  KDVQKRMYESE-----GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QLKD 535
            KD+Q R+ E+E     G  KQ+Q     ++E L  E      + TE +K       ++K+
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETRIRE-LEFELEGEQKKNTESVKGLRKYERRVKE 1850

Query: 536  LKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRK 595
            L  + E     V +L++ + + ++ V+ +KR   +  E+      +    + E E+   +
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910

Query: 596  VTEMEGQAKELSAK 609
                E Q  +L AK
Sbjct: 1911 ADIAESQVNKLRAK 1924


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  172 bits (435), Expect = 3e-42
 Identities = 237/1034 (22%), Positives = 464/1034 (44%), Gaps = 141/1034 (13%)

Query: 446  DRLKLQNEL-AHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 504
            +R + + E+ A   A+ + L  EC  +K+D D+    LE  L  V+K  + +E KVK + 
Sbjct: 927  ERAEEEEEINAELTAKKRKLEDECSELKKDIDD----LELTLAKVEKEKHATENKVKNLT 982

Query: 505  THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF 564
                 L E + ++ +     L E  +  L DL+       AE  K+    K    + ++ 
Sbjct: 983  EEMAGLDETI-AKLSKEKKALQETHQQTLDDLQ-------AEEDKVNILTKAKTKLEQQV 1034

Query: 565  KRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKELSAKLALSIPAEKFEN 621
               EG L +E K R+  E +  ++E + K       +ME   ++L  KL      EK E 
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKL------EKKEF 1088

Query: 622  MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE-----EHEQ 676
              S+L +++ ++    ++++++ ++  + I +L  E+E  +A  A+  K       E E+
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148

Query: 677  VKSRLEQKSG------ELGKK-----------ITELTLKNQTLQKEIEKVYLDNKL-LKE 718
            +  RLE+  G      EL KK           + E TL+++ +   + K + D+   L E
Sbjct: 1149 ISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGE 1208

Query: 719  QAHNLTI---EMKNHYVPLKV-SEDMKKSHDAI------IDDLNRKLLDVTQKYTEKKLE 768
            Q  NL     +++     LK+ ++D+  + +AI      ++ + R L D   +   K+ E
Sbjct: 1209 QIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268

Query: 769  MEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK----QLSELKKKCGED 824
             ++L+   + L+   +RL+T      +   E  AL S +   K+    Q+ ELK +  E+
Sbjct: 1269 QQRLI---NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325

Query: 825  QEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE-D 879
             +      HAL S   +   ++  QY   +  +E K  L   L+K N E+   + K+E D
Sbjct: 1326 TKAKNALAHALQSSRHDCD-LLREQY---EEEQEGKAELQRALSKANSEVAQWRTKYETD 1381

Query: 880  INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS----MRKVQDSNA- 934
              Q   ++++  + L + L+  +  ++A     A  E     L       M  V+ SNA 
Sbjct: 1382 AIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA 1441

Query: 935  ------------EILANYRKGQEEIVTLHAEIKAQKKELDTIQ-ECIKVKYAPIVSFEEC 981
                        ++L+ +++  EE     AE++A +KE  ++  E  KVK     S ++ 
Sbjct: 1442 CAALDKKQRNFDKVLSEWKQKYEET---QAELEASQKESRSLSTELFKVKNVYEESLDQL 1498

Query: 982  ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS 1041
            E   +   K L+ ++S+ T++ +   +++ + ++   ++++E   +Q  L +    +E  
Sbjct: 1499 ET-LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE-- 1555

Query: 1042 HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1101
            HE E  + R   ELN+   ++ +K  E     E++ +     T  +  +Q+ L  +    
Sbjct: 1556 HE-EGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHTRVVETMQSTLDAEIRSR 1611

Query: 1102 EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE 1161
                 +KK + G +  ++ +L    R   +  +       +L   K + + L + L+ +E
Sbjct: 1612 NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGIL---KETQLHLDDALRGQE 1668

Query: 1162 AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKS 1221
              ++++ I+       E  +     E+ +L + ++ T+++ +K+  +E++D S+      
Sbjct: 1669 DLKEQLAIV-------ERRANLLQAEIEELWATLEQTERS-RKIAEQELLDASERVQLLH 1720

Query: 1222 DLETQISSLNEKLAN----LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSI--EQEIKD 1275
               T + +  +KL N    L  + EEV +E  +A++K   A  +  ++   +  EQ+   
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780

Query: 1276 QKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITELLNDVE----RLKQAL 1322
              ER  K+L  T+ +LQ R+ E+         KQI+  + ++ EL  +VE    R  +A+
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV 1840

Query: 1323 NGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
             GL        +LTY +    K   R   L+D LQ +VKS ++Q  +A+ Q    ++ +R
Sbjct: 1841 KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900

Query: 1373 --THLLSAAQGHMD 1384
               H L  A+   D
Sbjct: 1901 KLQHELEEAEERAD 1914



 Score =  152 bits (383), Expect = 3e-36
 Identities = 212/1066 (19%), Positives = 459/1066 (43%), Gaps = 119/1066 (11%)

Query: 231  DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 286
            D+L+ LTL K   E     NK + L ++   L +      +++   K+ Q  HQ  + DL
Sbjct: 958  DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEK---KALQETHQQTLDDL 1013

Query: 287  EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 346
            + E    ++++  + + +  L  +V+ L+  L +E  +  DLE  + KL+  L   ++  
Sbjct: 1014 QAE----EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069

Query: 347  EESLRTIEALKNRF--KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHM 404
             +     + L  +   K FE  +L S        E  L K+ +   A  +     I A  
Sbjct: 1070 MDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAER 1129

Query: 405  QSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL---KLQNELAHKVAEC 461
             SR+        L S+     +E L++   A     E  K+      KL+ +L     + 
Sbjct: 1130 ASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH 1188

Query: 462  KALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASG 521
            +A+     +   DS  ++ +  D L+ V++++ + + ++K M+T  L+      S+A   
Sbjct: 1189 EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELK-METDDLSSNAEAISKAKGN 1247

Query: 522  NHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 581
              ++   L+DQ+ +LK K E     +  L  Q  + +    E+ R     ++E   L  +
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ----LDEKDALVSQ 1303

Query: 582  LSMCEMEREKKGRKVTEMEGQAKE-LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 640
            LS     ++   +++ E++ Q +E   AK AL+   +   +    L  +  E+ +   E+
Sbjct: 1304 LSR---SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1360

Query: 641  EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 700
            +R   K+ SE+ Q + + E    +     + EE E+ K +L Q+  E  + +  +  K  
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415

Query: 701  TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 760
            +L+K  ++       L+ +  +L ++++         +  +++ D ++ +         Q
Sbjct: 1416 SLEKTKQR-------LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK-------Q 1461

Query: 761  KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 820
            KY E + E+E    E+ SLS ++ +++ V+   E+   ++  L+     L++++S+L ++
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVY---EESLDQLETLRRENKNLQQEISDLTEQ 1518

Query: 821  CGEDQEKIHALTSENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFED 879
              E  ++IH L      +KK +  +   ++   EE + +L     K  R  L++ +   +
Sbjct: 1519 IAEGGKQIHELEK----IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSE 1574

Query: 880  INQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAEH-------EAKMSSLSQSMRK 928
            ++++  +  ++ + LKRN    +E  Q+ + AE  S  +        E  ++ +   +  
Sbjct: 1575 VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNH 1634

Query: 929  VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKAT 988
                 AE L NYR  Q         +K  +  LD                          
Sbjct: 1635 ANRLAAESLRNYRNTQ-------GILKETQLHLDDALR---------------------G 1666

Query: 989  EKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL 1048
            +++LK+QL+   ++ ++ + E+++     ++ ++     +++L D +  ++  H    +L
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1726

Query: 1049 SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALK 1108
                 +L   +  L  +  EV        E+  K  ++   +   L+K+      +E +K
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786

Query: 1109 KSLNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1160
            K+L  T+++L+          LK  ++  +K +  V +L   +EN++  +    + L+  
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846

Query: 1161 EAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1217
            E   KE+        + EE+ +N +   + V KLQ++V++ K+  ++ E +   +LSK++
Sbjct: 1847 ERRVKEL------TYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1263
              + +LE      +   + +N+         L  K +E+  K   E
Sbjct: 1901 KLQHELEEAEERADIAESQVNK---------LRVKSREVHTKISAE 1937



 Score =  144 bits (363), Expect = 6e-34
 Identities = 227/1045 (21%), Positives = 442/1045 (42%), Gaps = 149/1045 (14%)

Query: 398  PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL---EAMRTFCESAKQDRLKLQNEL 454
            P +    + + +L+  E      T   E +  K EL   EA R   E      LK +N+L
Sbjct: 831  PWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL 890

Query: 455  AHKV-AECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 513
              +V +E  +LA   ER ++    +I QLE  +K+V +R  E E    ++     A K  
Sbjct: 891  QLQVQSEADSLADAEERCEQLIKNKI-QLEAKIKEVTERAEEEE----EINAELTAKKRK 945

Query: 514  LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 573
            L  E +        ELK  + DL++       E     N++K               L E
Sbjct: 946  LEDECS--------ELKKDIDDLELTLAKVEKEKHATENKVKN--------------LTE 983

Query: 574  ENKRLQKELSMCEMEREKKGRKVTEMEG----QAKELSAKLALSIPAEKFENMKSSLSNE 629
            E   L + ++  ++ +EKK  + T  +     QA+E    + L+    K E     L   
Sbjct: 984  EMAGLDETIA--KLSKEKKALQETHQQTLDDLQAEEDKVNI-LTKAKTKLEQQVDDLEGS 1040

Query: 630  VNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQHVKPEEHE--QVKSRLEQK 684
            + ++ K  +++ER   K   +++  +    ++EN K +L + ++ +E E   + S++E +
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100

Query: 685  SG---ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 741
                 +L KKI EL  + + L +EIE         ++Q  +L+ E++      ++SE ++
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELE------EISERLE 1154

Query: 742  KSHDAIID--DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKE 799
            ++  A     +LN+K     QK    + ++E+  L+++++         V    +KH   
Sbjct: 1155 EAGGATSAQVELNKKREAEFQKL---RRDLEEATLQHEAM---------VAALRKKHADS 1202

Query: 800  IIALKSNI-------VELKKQLSELKKKCGEDQEKIHALTSENTNLKKM---MSNQYVPV 849
            +  L   I        +L+K+ SELK +  +      A++    NL+KM   + +Q   +
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262

Query: 850  KTHEEVKMTL-NDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 908
            KT EE +  L ND  A+  R   +  +    ++++   +      L R+ + +  QI+  
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEEL 1318

Query: 909  YISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECI 968
               L E     ++L+ +++  +     +   Y + QE    L   +     E+   Q   
Sbjct: 1319 KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV--AQWRT 1376

Query: 969  KVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1028
            K +   I   EE E        E K +L+++ Q+   +EE V+    +   L+K    LQ
Sbjct: 1377 KYETDAIQRTEELE--------EAKKKLAQRLQE---AEEHVEAVNAKCASLEKTKQRLQ 1425

Query: 1029 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIL 1088
             ++ D  + +E+S+    AL +K    +K L +  QKY E +   E   +E+   ++E+ 
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485

Query: 1089 AVQNLLQKQHVPLEQVEALKKSLNGTIENLKE-------ELKSMQRCYEKEQQTVTKLHQ 1141
             V+N+ ++    LE +    K+L   I +L E       ++  +++  ++ +Q   ++  
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545

Query: 1142 LLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
             LE  + S     EH + K    + E+  +K+ +  K  E   +++++ +  + V  T Q
Sbjct: 1546 ALEEAEAS----LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQ 1601

Query: 1201 ALKKLETREVVDL----SKYKATKSDLETQISSLNEKLANLNRKY--------------- 1241
            +    E R   D      K +   +++E Q++  N   A   R Y               
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLD 1661

Query: 1242 ------EEVCEE---------VLHAKKKEISAK-DEKELLHFSIEQEIKDQKERCDKSLT 1285
                  E++ E+         +L A+ +E+ A  ++ E      EQE+ D  ER     T
Sbjct: 1662 DALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHT 1721

Query: 1286 TITEL---QRRIQESAKQIEAK-DNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1341
              T L   +++++    Q++++ +  I E  N  E+ K+A+   + +        K++  
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM----AEELKKEQD 1777

Query: 1342 LIDTLQHQVKSLEQQLADADRQHQE 1366
                L+   K+LEQ + D   +  E
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDE 1802



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 81/396 (20%), Positives = 179/396 (45%), Gaps = 50/396 (12%)

Query: 984  KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK--- 1040
            K   TEKE+   + E+ QK   +++E+ K++ +  +L++++ TL K+  D  + ++    
Sbjct: 844  KSAETEKEMAT-MKEEFQK---TKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD 899

Query: 1041 ----SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1096
                + E    L +   +L  ++K+++++  E + +  +L  +  K   E   ++  +  
Sbjct: 900  SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD 959

Query: 1097 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1156
              + L +VE  K +    ++NL EE+  +        +T+ KL +  +  + +     + 
Sbjct: 960  LELTLAKVEKEKHATENKVKNLTEEMAGLD-------ETIAKLSKEKKALQETHQQTLDD 1012

Query: 1157 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1216
            LQ +E     +   K  L ++ ++ +  +E+  KL+ +++  K+ L+        DL   
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG-------DLKLA 1065

Query: 1217 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1276
            + +  D+E     L+EKL    +K  E+           IS  ++++ +   ++++IK  
Sbjct: 1066 QESTMDMENDKQQLDEKL---EKKEFEI--------SNLISKIEDEQAVEIQLQKKIK-- 1112

Query: 1277 KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPT 1336
                        ELQ RI+E  ++IEA+     +       L + L  +S+    +G  T
Sbjct: 1113 ------------ELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160

Query: 1337 KRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
              Q +L    + + + L + L +A  QH+ ++A  R
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  171 bits (434), Expect = 3e-42
 Identities = 231/1121 (20%), Positives = 477/1121 (42%), Gaps = 122/1121 (10%)

Query: 277  QREHQNIQDLEIENEDLKERLRKIQQEQRI-----LLDKVNGLQLQLNEEVMVADDLESE 331
            Q   Q  + +  E E +K R +++  E R+     L  ++   +LQL E++    +L +E
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 332  REKLKSLLAAKEKQHEESLRTIEAL----KNRFKYFESDHLGSGSHFSNRKEDMLLKQG- 386
             E+L++ L AK+++ EE    +EA     + R ++ +++      +    +E +  ++  
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958

Query: 387  -QMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ 445
             Q    +   T   +    + + +L      L  +    E+ I   E     T  E   +
Sbjct: 959  RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRI--AEFTTNLTEEEEKSK 1016

Query: 446  DRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQT 505
               KL+N+    + + +      E+ +++ ++  ++LE    D+  ++ E + ++ +++ 
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076

Query: 506  HFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFK 565
                 +E L +  A    R+ EE   +   LK        ++ +L +QI + +  +E  +
Sbjct: 1077 QLAKKEEELQAALA----RVEEEAAQKNMALK--------KIRELESQISELQEDLESER 1124

Query: 566  RDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFEN-MKS 624
                K  ++ + L +EL   +          TE+E      +A+  L    E+  N +K 
Sbjct: 1125 ASRNKAEKQKRDLGEELEALK----------TELEDTLDSTAAQQELRSKREQEVNILKK 1174

Query: 625  SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQK 684
            +L  E      ++ EM ++H +++ E+ +   + + VKA L         E+ K  LE +
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL---------EKAKQTLENE 1225

Query: 685  SGELGKKITELTL---KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK 741
             GEL  ++  L      ++  +K++E    + ++   +   +  E+ +    L+V  D  
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285

Query: 742  KSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEND----SLSKDVSRLE----TVFVPP 793
                +  D  + KL         +  + ++LL E +    SLS  + ++E    +     
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345

Query: 794  EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 853
            E+ E+    L+  I  L  Q++++KKK    ++ +  L +     +K+  +     + HE
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKM---EDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402

Query: 854  EVKMTLNDTLAKT----NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 909
            E K+   D L KT     +EL D+    +   Q    ++ K +   + L   +  I A+Y
Sbjct: 1403 E-KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE-EKTISAKY 1460

Query: 910  --------ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANYRKGQEEIVTLHAEIKAQK 958
                        E E K  SL++++ +  +  AE   +   +R   E++++   ++    
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520

Query: 959  KELDTIQECIKVKYAPI-VSFEECERKFKATE-KELKDQLSEQTQKYSVSEEEVKKNKQE 1016
             EL+  +  ++ +   +    EE E + +ATE  +L+ +++ Q  K     +   +++Q 
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580

Query: 1017 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1076
             +K K+    L + +R+    +E   +          +L   LKDL          +++ 
Sbjct: 1581 EEKKKQ----LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636

Query: 1077 VEENAKQTSEILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCY 1129
            +++  K  +++      L       E++       E   KS+   +  L+EEL + +R  
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696

Query: 1130 EKEQQTVTKLHQLLENQKNSSVPLAEH--------LQIKEAFEKEVG--------IIKAS 1173
             + QQ   +L   + N         E          Q++E  E+E G        + KA+
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756

Query: 1174 LREKE-------EESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ 1226
            L+  +       E S  +  E ++ Q E QN K+   KL+  E    SKYKA+ + LE +
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQN-KELKVKLQEMEGTVKSKYKASITALEAK 1815

Query: 1227 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ-KERCDKSLT 1285
            I+ L E+L N  ++ +  C++V   +KK    KD   LL    E+   +Q K++ DK+ T
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKK---LKD--VLLQVDDERRNAEQYKDQADKAST 1870

Query: 1286 TITELQRRIQES---AKQIEAKDNKITELLNDVERLKQALN 1323
             + +L+R+++E+   A++  A   K+   L D      A+N
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911



 Score =  156 bits (395), Expect = 1e-37
 Identities = 178/857 (20%), Positives = 373/857 (43%), Gaps = 82/857 (9%)

Query: 555  KQNEMI-VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALS 613
            K+ E++ V E +      + E + LQ +L   +++ +++ +  TE+  +A+EL A+L   
Sbjct: 850  KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909

Query: 614  IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEE 673
               ++ E +   L   V E+ ++   ++ E +K    I++L+ +LE            EE
Sbjct: 910  --KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE-----------EE 956

Query: 674  HEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVP 733
              + K +LE+ + E   K+ +L  +   L+ +  K+  + KLL+++    T  +      
Sbjct: 957  SARQKLQLEKVTTEA--KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 734  LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS--LSKDVSRLETVFV 791
             K    +K  H+A+I DL  +L    ++   ++LE  +  LE DS  LS  ++ L+    
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLR--REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072

Query: 792  PPE----KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT----SENTNLKKMMS 843
              +    K E+E+ A  + + E   Q +   KK  E + +I  L     SE  +  K   
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132

Query: 844  NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQN 903
             +    +  E +K  L DTL  T  +     K+ +++N           ILK+ LE    
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN-----------ILKKTLEE--- 1178

Query: 904  QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL-- 961
            + K     + E   K S   + + +  +    + AN  K ++ +     E+  + K L  
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 962  ---DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEV----KKNK 1014
               D+  +  KV+       +E + KF   E+ ++ +L+++  K  V  + V     ++ 
Sbjct: 1239 GKGDSEHKRKKVE----AQLQELQVKFNEGER-VRTELADKVTKLQVELDNVTGLLSQSD 1293

Query: 1015 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1074
             ++ KL K+   L+  L+D   L+++ +  + +LS K  ++  +     ++  E +  K 
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 1075 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1134
             L ++ A   +++  ++  ++     LE  E +K+ L   +E L +  +     Y+K ++
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413

Query: 1135 TVTKLHQLLEN------------------QKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1176
            T T+L Q L++                  QK     LAE   I   + +E    +A  RE
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473

Query: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
            KE     K   +++   E    K  L++L  +   ++    ++K D+   +  L +    
Sbjct: 1474 KE----TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA 1529

Query: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE----QEIKDQKERCDKSLTTITELQR 1292
            L ++ EE+  ++   + +  + +D K  L  +++    Q  +D + R ++S     +L R
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589

Query: 1293 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKS 1352
            +++E   ++E +  + +  +   ++L+  L  L     ++        + +  LQ Q+K 
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

Query: 1353 LEQQLADADRQHQEVIA 1369
              ++L D     +E++A
Sbjct: 1650 CMRELDDTRASREEILA 1666



 Score =  134 bits (338), Expect = 5e-31
 Identities = 202/1033 (19%), Positives = 433/1033 (41%), Gaps = 112/1033 (10%)

Query: 261  QRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNE 320
            Q+N+  +++++  +   R     Q L++E    + +L+K+++EQ IL D+      +L +
Sbjct: 942  QQNIQELEEQLEEEESAR-----QKLQLEKVTTEAKLKKLEEEQIILEDQ----NCKLAK 992

Query: 321  EVMVADD--------LESEREKLKSLLAAKEKQH------EESLRTIEALKNRFKYFESD 366
            E  + +D        L  E EK KSL   K K        EE LR  E  +   +     
Sbjct: 993  EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052

Query: 367  HLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSEN 426
              G  +  S++  ++     Q  +A+ +         +Q+ ++ R  E +     +  + 
Sbjct: 1053 LEGDSTDLSDQIAEL-----QAQIAELKMQLAKKEEELQA-ALARVEEEAAQKNMALKKI 1106

Query: 427  EILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDS--DEQIKQLED 484
              L+ ++  ++   ES +  R K + +      E +AL  E E   + +   ++++   +
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166

Query: 485  ALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS 544
               ++ K+  E E K  + Q   +  K     E  +     T+ +K  L+  K   E   
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN-- 1224

Query: 545  AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK 604
             E G+L N++K       + +    K+  + + LQ + +  E  R +   KVT+++ +  
Sbjct: 1225 -ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283

Query: 605  ELSAKLALS-IPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 663
             ++  L+ S   + K     S+L +++ +  + L E  R+     ++++Q++ E  + + 
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343

Query: 664  KLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 723
            +L      EE E+ K  LE++   L  ++ ++  K +     +E      + L++    L
Sbjct: 1344 QL------EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397

Query: 724  TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQK------YTEKKLEMEKLLLEND 777
            +   + H   +   + ++K+   +  +L+  L+D+  +        +K+ + ++LL E  
Sbjct: 1398 S---QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454

Query: 778  SLSKDVSRLETVFVPPEKHEKEIIALK-----SNIVELKKQLSELKKKCGEDQE------ 826
            ++S   +  E      E  EKE  AL         +E K +L  L K+   + E      
Sbjct: 1455 TISAKYAE-ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513

Query: 827  -----KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 881
                  +H L      L++ +      ++  E+      D   +    L  +K +FE   
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--- 1570

Query: 882  QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY- 940
            ++     +++E  K+ L     +++AE     E E K  S++ + RK  + + + L  + 
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAEL----EDERKQRSMAVAARKKLEMDLKDLEAHI 1626

Query: 941  ---RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 997
                K ++E +    +++AQ K+      C++       S EE   + K  EK+LK   +
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKD------CMRELDDTRASREEILAQAKENEKKLKSMEA 1680

Query: 998  EQTQ---KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDE 1054
            E  Q   + + +E   ++ +QE D+L  EI           + +E+   +E  +++  +E
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEI---ANSSGKGALALEEKRRLEARIAQLEEE 1737

Query: 1055 LNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL-LQKQHVPLEQVEALKKSLNG 1113
            L ++     Q  TE+ N + K       Q +  L ++    QK     +Q+E   K L  
Sbjct: 1738 LEEE-----QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792

Query: 1114 TIENLKEELKSMQRC-YEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKA 1172
             ++ ++  +KS  +      +  + +L + L+N+        + ++  E   K+V +   
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852

Query: 1173 SLREKEEESQNKMEEVS-----------KLQSEVQNTKQALKKLETREVVDLSKYKATKS 1221
              R   E+ +++ ++ S           + + E Q    + +KL+ RE+ D ++   T  
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ-RELEDATE---TAD 1908

Query: 1222 DLETQISSLNEKL 1234
             +  ++SSL  KL
Sbjct: 1909 AMNREVSSLKNKL 1921



 Score =  107 bits (267), Expect = 8e-23
 Identities = 182/929 (19%), Positives = 370/929 (39%), Gaps = 139/929 (14%)

Query: 235  ILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLK 294
            ++T L+       K R+  +K     + + T + D++     Q     +Q L  + E+L+
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ-LAKKEEELQ 1086

Query: 295  ERLRKIQQE---QRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLR 351
              L ++++E   + + L K+  L+ Q++E   + +DLESER          EKQ  +   
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISE---LQEDLESERASRNKA----EKQKRDLGE 1139

Query: 352  TIEALKNRFKYFESDHLGSGSHFSNRKEDM-LLKQG-------------QMYMADSQCTS 397
             +EALK   +             S R++++ +LK+              +M    SQ   
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199

Query: 398  PGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHK 457
                   Q++ +   LE +   QT  +E   L  E++ +      ++  R K++ +L   
Sbjct: 1200 ELAEQLEQTKRVKANLEKA--KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ-- 1255

Query: 458  VAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSE 517
              E +    E ERV+ +  +++ +L+  L +V   + +S+ K  ++   F AL+  L   
Sbjct: 1256 --ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD- 1312

Query: 518  AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD----EGKLIE 573
                   L +E   Q   L  K +    E    R Q+++ E      ++       ++ +
Sbjct: 1313 ----TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368

Query: 574  ENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEK 633
              K+++  +   E   E K +   ++EG ++    K+A     +K E  K+ L  E+++ 
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY---DKLEKTKTRLQQELDDL 1425

Query: 634  AKKLVEMEREH------EKSLSEIRQLKRELENVKAKLAQHVKPEEHE------------ 675
               LV+++ +       EK   +  QL  E + + AK A+     E E            
Sbjct: 1426 ---LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482

Query: 676  -------QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 728
                   + K+ LE+ + +   ++ +L      + K + ++    + L++Q   +  +++
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542

Query: 729  NHYVPLKVSEDMKKSHD----AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS 784
                 L+ +ED K   +    A+     R L    ++  EKK ++ + + E ++  +D  
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602

Query: 785  RLETVFVPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 836
            +  ++ V   K         E  I +   N  E  KQL +L+ +  +   ++    +   
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662

Query: 837  NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL-- 894
             +          +K+ E   + L + LA   R     +++ +++  E      K  +   
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722

Query: 895  -KRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQ--------DSNAEILANYRKGQE 945
             KR LE    Q++ E   L E +     ++  ++K          D N E  ++ +K + 
Sbjct: 1723 EKRRLEARIAQLEEE---LEEEQGNTELINDRLKKANLQIDQINTDLNLE-RSHAQKNEN 1778

Query: 946  EIVTLHAEIKAQKKELDTIQECIKVKY--------APIVSFEE------------CERKF 985
                L  + K  K +L  ++  +K KY        A I   EE            C ++ 
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAAC-KQV 1837

Query: 986  KATEKELKD-------------QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT----LQ 1028
            + TEK+LKD             Q  +Q  K S   +++K+  +E ++  +        LQ
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897

Query: 1029 KDLRDKTVLIEKSHEMERALSRKTDELNK 1057
            ++L D T   E +  M R +S   ++L +
Sbjct: 1898 RELEDAT---ETADAMNREVSSLKNKLRR 1923



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 75/378 (19%), Positives = 156/378 (41%), Gaps = 67/378 (17%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQ-RNLTHMQDEVNVKSHQREHQNI--QDLEIENED 292
            L  +K   E   +GR+   +    Q  R +  M+ E+  +  QR       + LE++ +D
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621

Query: 293  LKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRT 352
            L+  +    + +   + ++  LQ Q+ + +   DD  + RE++     A+ K++E+ L++
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEI----LAQAKENEKKLKS 1677

Query: 353  IEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPG-----IPAHMQSR 407
            +EA   + +    + L +      + +     Q +  +AD    S G     +    +  
Sbjct: 1678 MEAEMIQLQ----EELAAAERAKRQAQ-----QERDELADEIANSSGKGALALEEKRRLE 1728

Query: 408  SMLRPLELSLPSQTSYSE--NEILKK----------ELEAMRTFC---ESAKQDRLKLQN 452
            + +  LE  L  +   +E  N+ LKK          +L   R+     E+A+Q   +   
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788

Query: 453  ELAHKVAECK------------ALALECERVKEDSD----------EQIKQLEDALKDVQ 490
            EL  K+ E +            AL  +  +++E  D          +Q+++ E  LKDV 
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848

Query: 491  KRMYESEGKVKQMQ-------THFLALKEHL--TSEAASGNHRLTEELKDQLKDLKVKYE 541
             ++ +     +Q +       T    LK  L    E A   +    +L+ +L+D     +
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908

Query: 542  GASAEVGKLRNQIKQNEM 559
              + EV  L+N++++ ++
Sbjct: 1909 AMNREVSSLKNKLRRGDL 1926


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  171 bits (434), Expect = 3e-42
 Identities = 236/1050 (22%), Positives = 468/1050 (44%), Gaps = 145/1050 (13%)

Query: 430  KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
            K +LEA         +D  ++  EL    A+ + L  EC  +K+D D+    LE  L  V
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 970

Query: 490  QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 549
            +K  + +E KVK +      L E +         +LT+E K   +  +   +   AE  K
Sbjct: 971  EKEKHATENKVKNLTEEMAGLDETIA--------KLTKEKKALQEAHQQTLDDLQAEEDK 1022

Query: 550  LRNQIKQNEMIVEEFKRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKEL 606
            +    K    + ++    EG L +E K R+  E +  ++E + K     + ++E + ++L
Sbjct: 1023 VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
              KL      +K E   S+L +++ ++    ++++++ ++  + I +L+ E+E  +A  A
Sbjct: 1083 DEKL------KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136

Query: 667  QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 704
            +  K       E E++  RLE+  G      E+ KK           + E TL+++    
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 705  EIEKVYLDNKL-LKEQAHNLT----------IEMKNHYVPLKVSEDMKKSHDAIIDDLNR 753
             + K + D+   L EQ  NL            EMK     L  + +        ++ + R
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256

Query: 754  KLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK- 812
             L D   +   K+ E ++L+   + L+    RL+T      +   E  AL S +   K+ 
Sbjct: 1257 TLEDQLSELKSKEEEQQRLI---NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313

Query: 813  ---QLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865
               Q+ ELK++  E+ +      HAL S   +   ++  QY   +  +E K  L   L+K
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD-LLREQY---EEEQESKAELQRALSK 1369

Query: 866  TNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQ 924
             N E+   + K+E D  Q   ++++  + L + L+  +  ++A     A  E     L  
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 925  S----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIKAQKKELDTI-QE 966
                 M  V+ +NA             +ILA +++  EE    HAE++A +KE  ++  E
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELEASQKEARSLGTE 1486

Query: 967  CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1026
              K+K A   S ++ E   K   K L+ ++S+ T++ +   + + + ++   ++++E   
Sbjct: 1487 LFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ  L +    +E  HE E  + R   ELN+   ++ +K  E    K++ +++  +    
Sbjct: 1546 LQAALEEAEASLE--HE-EGKILRIQLELNQVKSEVDRKIAE----KDEEIDQLKRNHIR 1598

Query: 1087 IL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1145
            I+ ++Q+ L  +         LKK + G +  ++ +L    R   +  +       +L  
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-- 1656

Query: 1146 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1205
             K++ + L + L+ +E  ++++ ++       E  +     E+ +L++ ++ T+++ +K+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELRATLEQTERS-RKI 1707

Query: 1206 ETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDE 1261
              +E++D S+         T + +  +KL    + +  + E++ +E  +A++K   A  +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767

Query: 1262 KELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITE 1310
              ++   +  EQ+     ER  K++  T+ +LQ R+ E+         KQI+  + ++ E
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827

Query: 1311 LLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQ 1356
            L  +VE    R  +A+ GL        +LTY +    K   R   L+D LQ +VKS ++Q
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887

Query: 1357 LADADRQHQEVIAIYR--THLLSAAQGHMD 1384
              +A+ Q    +A +R   H L  A+   D
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917



 Score =  143 bits (360), Expect = 1e-33
 Identities = 221/1027 (21%), Positives = 446/1027 (43%), Gaps = 123/1027 (11%)

Query: 270  EVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILL--------------DKVNGL- 314
            +V  + H  E++ +++L  E   L E + K+ +E++ L               DKVN L 
Sbjct: 969  KVEKEKHATENK-VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027

Query: 315  --QLQLNEEVMVADDLESEREKLKSL----------LAAKEKQHEESLRTIEALKNRF-- 360
              +++L ++V   DDLE   E+ K L          L    K  +ES+  IE  K +   
Sbjct: 1028 KAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 361  ----KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS 416
                K FE  +L S           L K+ +   A  +     I A   SR+        
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144

Query: 417  LPSQTSYSENEILKKELEAMRTFCESAKQ---DRLKLQNELAHKVAECKALALECERVKE 473
            L S+     +E L++   A     E  K+   +  K++ +L     + +A A    +   
Sbjct: 1145 L-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203

Query: 474  DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 533
            DS  ++ +  D L+ V++++ + + ++K M+   LA      S+A     ++   L+DQL
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262

Query: 534  KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
             +LK K E     +  L  Q  + +    EF R     ++E + L  +LS     ++   
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LDEKEALVSQLS---RGKQAFT 1315

Query: 594  RKVTEMEGQ-AKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 652
            +++ E++ Q  +E+ AK AL+   +   +    L  +  E+ +   E++R   K+ +E+ 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 653  QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 712
            Q + + E    +     + EE E+ K +L Q+     + +  +  K  +L+K  ++    
Sbjct: 1376 QWRTKYETDAIQ-----RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---- 1426

Query: 713  NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 772
               L+ +  +L ++++         +  +++ D I       L +  QK  E   E+E  
Sbjct: 1427 ---LQNEVEDLMLDVERTNAACAALDKKQRNFDKI-------LAEWKQKCEETHAELEAS 1476

Query: 773  LLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 832
              E  SL  ++ +++  +   E+   ++  LK     L++++S+L ++  E  ++IH L 
Sbjct: 1477 QKEARSLGTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL- 1532

Query: 833  SENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 891
                 +KK +  +   ++   EE + +L     K  R  L++ +   +++++  +  ++ 
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589

Query: 892  EILKRN----LENTQNQIKAEYIS-------LAEHEAKMSSLSQSMRKVQDSNAEILANY 940
            + LKRN    +E+ Q+ + AE  S         + E  ++ +   +       AE L NY
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649

Query: 941  RKGQ----EEIVTLHAEIKAQ---KKELDTIQECIKVKYAPI----VSFEECERKFKATE 989
            R  Q    +  + L   +++Q   K++L  ++    +  A I     + E+ ER  K  E
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709

Query: 990  KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1049
            +EL D  SE+ Q        +   K+   KL+ +I  +Q ++ D  +L E  +  E+A  
Sbjct: 1710 QELLD-ASERVQLLHTQNTSLINTKK---KLETDISQMQGEMED--ILQEARNAEEKAKK 1763

Query: 1050 RKTD------ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1103
              TD      EL K+ +D S     +K   E+ V++   +  E  A Q  L+     +++
Sbjct: 1764 AITDAAMMAEELKKE-QDTSAHLERMKKNMEQTVKDLQLRLDE--AEQLALKGGKKQIQK 1820

Query: 1104 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL-HQLLENQKNSSVPLAEHLQIKEA 1162
            +EA  + L G +E+ ++      +   K ++ V +L +Q  E++KN    +     + + 
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN----ILRLQDLVDK 1876

Query: 1163 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1222
             + +V   K    E EE+S   + +  KLQ E++  ++     E++    ++K +    +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSRE 1932

Query: 1223 LETQISS 1229
            + T++ S
Sbjct: 1933 VHTKVIS 1939



 Score =  127 bits (320), Expect = 6e-29
 Identities = 187/905 (20%), Positives = 381/905 (42%), Gaps = 147/905 (16%)

Query: 570  KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 629
            K + ++   +KE++  + E +K   ++ + E + KEL  K+   +        K+ L  +
Sbjct: 843  KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE------KNDLQLQ 896

Query: 630  VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 689
            V  +A+ L + E   ++ +    QL+ +++ V  +       E+ E++ + L  K  +L 
Sbjct: 897  VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA------EDEEEINAELTAKKRKLE 950

Query: 690  KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 749
             + +EL       +K+I+ + L    ++++ H    ++KN      ++E+M     A +D
Sbjct: 951  DECSEL-------KKDIDDLELTLAKVEKEKHATENKVKN------LTEEM-----AGLD 992

Query: 750  DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVE 809
            +   KL        EKK   E      D L  +  ++ T+     K E+++  L+ ++ +
Sbjct: 993  ETIAKLT------KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

Query: 810  LKK---QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 866
             KK    L   K+K   D +    L  E+             +   E  K  L++ L K 
Sbjct: 1047 EKKLRMDLERAKRKLEGDLK----LAQES-------------IMDIENEKQQLDEKLKKK 1089

Query: 867  NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 926
              E+ +++ K ED     ++++ K + L+  +E  + +I+AE  S A+ E + S LS+ +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 927  RKVQD--------SNAEILANYRKGQE--------EIVTLHAEIKA---QKKELDTIQEC 967
             ++ +        ++A+I  N ++  E        E  TL  E  A   +KK  D++ E 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 968  --------------------IKVKYAPIVSFEECERKFKATEKE----LKDQLSEQTQKY 1003
                                +K++   + S  E   K K   ++    L+DQLSE   K 
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-- 1061
               +  +     +  +L+ E     + L +K  L+ +    ++A +++ +EL +QL++  
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329

Query: 1062 -------------------LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-L 1101
                               L ++Y E +  K +L    +K  +E+   +   +   +   
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 1102 EQVEALKKSLNGTIENLKEELKSMQ-RCYEKE---QQTVTKLHQLLENQKNSSVPLAEHL 1157
            E++E  KK L   ++  +E ++++  +C   E   Q+   ++  L+ + + ++   A   
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 1158 QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1217
            + +  F+K +   K    E   E +   +E   L +E+   K A ++     +  L   K
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE----SLDQLETLK 1505

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
                +L+ +IS L E++A   ++  E     L   KK++  + EK  L  ++E+     +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKCELQAALEEAEASLE 1558

Query: 1278 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1337
                K L    EL +   E  ++I  KD +I +L  +  R+ +++         S N   
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618

Query: 1338 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQE 1389
            R   L   ++  +  +E QL  A+R   E +  YR    +L   Q H+D      ED++E
Sbjct: 1619 R---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675

Query: 1390 ALLQI 1394
             L  +
Sbjct: 1676 QLAMV 1680



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 134/795 (16%), Positives = 315/795 (39%), Gaps = 50/795 (6%)

Query: 200  RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSL 259
            RD  E  +++ A  + L     DS   A +G+ +D L  +K   E      ++     + 
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

Query: 260  QQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN 319
                ++  +  +       E Q + +L+ + E+ +  +  +  ++  L  +      QL+
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298

Query: 320  EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 379
            E+  +   L   ++     +   ++Q EE ++   AL +  +    D       +   +E
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 380  DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 439
                 Q  +  A+++          ++ ++ R  EL    +      +  ++ +EA+   
Sbjct: 1359 SKAELQRALSKANTEVAQ--WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416

Query: 440  CESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYES 496
            C S ++ + +LQNE+   + + +     C   ++ + + D+ + + +   ++    +  S
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476

Query: 497  EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
            + + + + T    +K               EE  DQL+ LK + +    E+  L  QI +
Sbjct: 1477 QKEARSLGTELFKIKNAY------------EESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA 616
                + E ++ + ++ +E   LQ  L   E   E +  K+  ++ +  ++ +++   I A
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-A 1583

Query: 617  EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ 676
            EK E +     N +         ++ E       IR LK+++E    ++   +       
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMA 1642

Query: 677  VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKV 736
             ++    ++ +   K T++ L +    +E  K  L   +++ +A+ L  E++     L+ 
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL--AMVERRANLLQAEIEELRATLEQ 1700

Query: 737  SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH 796
            +E  +K  +       ++LLD +++       ++ L  +N SL     +LET     +  
Sbjct: 1701 TERSRKIAE-------QELLDASER-------VQLLHTQNTSLINTKKKLETDISQMQGE 1746

Query: 797  EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY--VPVKTHEE 854
             ++I+    N  E  K+         E+ +K    ++    +KK M      + ++  E 
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806

Query: 855  VKMTLN------DTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 908
             ++ L         L    REL    +  +  N E VK   K+E   + L     + +  
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866

Query: 909  YISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
             + L +     +AK+ S  +   + ++ +   LA +RK Q E+          + +++ +
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 965  QECIKVKYAPIVSFE 979
            +   +  +  ++S E
Sbjct: 1927 RVKSREVHTKVISEE 1941


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  171 bits (434), Expect = 3e-42
 Identities = 236/1050 (22%), Positives = 468/1050 (44%), Gaps = 145/1050 (13%)

Query: 430  KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
            K +LEA         +D  ++  EL    A+ + L  EC  +K+D D+    LE  L  V
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 970

Query: 490  QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 549
            +K  + +E KVK +      L E +         +LT+E K   +  +   +   AE  K
Sbjct: 971  EKEKHATENKVKNLTEEMAGLDETIA--------KLTKEKKALQEAHQQTLDDLQAEEDK 1022

Query: 550  LRNQIKQNEMIVEEFKRDEGKLIEENK-RLQKELSMCEMEREKK--GRKVTEMEGQAKEL 606
            +    K    + ++    EG L +E K R+  E +  ++E + K     + ++E + ++L
Sbjct: 1023 VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
              KL      +K E   S+L +++ ++    ++++++ ++  + I +L+ E+E  +A  A
Sbjct: 1083 DEKL------KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136

Query: 667  QHVKPE-----EHEQVKSRLEQKSG------ELGKK-----------ITELTLKNQTLQK 704
            +  K       E E++  RLE+  G      E+ KK           + E TL+++    
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 705  EIEKVYLDNKL-LKEQAHNLT----------IEMKNHYVPLKVSEDMKKSHDAIIDDLNR 753
             + K + D+   L EQ  NL            EMK     L  + +        ++ + R
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256

Query: 754  KLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK- 812
             L D   +   K+ E ++L+   + L+    RL+T      +   E  AL S +   K+ 
Sbjct: 1257 TLEDQLSELKSKEEEQQRLI---NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313

Query: 813  ---QLSELKKKCGEDQEK----IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865
               Q+ ELK++  E+ +      HAL S   +   ++  QY   +  +E K  L   L+K
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD-LLREQY---EEEQESKAELQRALSK 1369

Query: 866  TNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQ 924
             N E+   + K+E D  Q   ++++  + L + L+  +  ++A     A  E     L  
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 925  S----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIKAQKKELDTI-QE 966
                 M  V+ +NA             +ILA +++  EE    HAE++A +KE  ++  E
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELEASQKEARSLGTE 1486

Query: 967  CIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1026
              K+K A   S ++ E   K   K L+ ++S+ T++ +   + + + ++   ++++E   
Sbjct: 1487 LFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ  L +    +E  HE E  + R   ELN+   ++ +K  E    K++ +++  +    
Sbjct: 1546 LQAALEEAEASLE--HE-EGKILRIQLELNQVKSEVDRKIAE----KDEEIDQLKRNHIR 1598

Query: 1087 IL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1145
            I+ ++Q+ L  +         LKK + G +  ++ +L    R   +  +       +L  
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL-- 1656

Query: 1146 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1205
             K++ + L + L+ +E  ++++ ++       E  +     E+ +L++ ++ T+++ +K+
Sbjct: 1657 -KDTQIHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELRATLEQTERS-RKI 1707

Query: 1206 ETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEVLHAKKKEISAKDE 1261
              +E++D S+         T + +  +KL    + +  + E++ +E  +A++K   A  +
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITD 1767

Query: 1262 KELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA--------KQIEAKDNKITE 1310
              ++   +  EQ+     ER  K++  T+ +LQ R+ E+         KQI+  + ++ E
Sbjct: 1768 AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1827

Query: 1311 LLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLIDTLQHQVKSLEQQ 1356
            L  +VE    R  +A+ GL        +LTY +    K   R   L+D LQ +VKS ++Q
Sbjct: 1828 LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1887

Query: 1357 LADADRQHQEVIAIYR--THLLSAAQGHMD 1384
              +A+ Q    +A +R   H L  A+   D
Sbjct: 1888 AEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917



 Score =  143 bits (360), Expect = 1e-33
 Identities = 221/1027 (21%), Positives = 446/1027 (43%), Gaps = 123/1027 (11%)

Query: 270  EVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILL--------------DKVNGL- 314
            +V  + H  E++ +++L  E   L E + K+ +E++ L               DKVN L 
Sbjct: 969  KVEKEKHATENK-VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027

Query: 315  --QLQLNEEVMVADDLESEREKLKSL----------LAAKEKQHEESLRTIEALKNRF-- 360
              +++L ++V   DDLE   E+ K L          L    K  +ES+  IE  K +   
Sbjct: 1028 KAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 361  ----KYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS 416
                K FE  +L S           L K+ +   A  +     I A   SR+        
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144

Query: 417  LPSQTSYSENEILKKELEAMRTFCESAKQ---DRLKLQNELAHKVAECKALALECERVKE 473
            L S+     +E L++   A     E  K+   +  K++ +L     + +A A    +   
Sbjct: 1145 L-SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA 1203

Query: 474  DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL 533
            DS  ++ +  D L+ V++++ + + ++K M+   LA      S+A     ++   L+DQL
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262

Query: 534  KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
             +LK K E     +  L  Q  + +    EF R     ++E + L  +LS     ++   
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQ----LDEKEALVSQLS---RGKQAFT 1315

Query: 594  RKVTEMEGQ-AKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR 652
            +++ E++ Q  +E+ AK AL+   +   +    L  +  E+ +   E++R   K+ +E+ 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 653  QLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLD 712
            Q + + E    +     + EE E+ K +L Q+     + +  +  K  +L+K  ++    
Sbjct: 1376 QWRTKYETDAIQ-----RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---- 1426

Query: 713  NKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKL 772
               L+ +  +L ++++         +  +++ D I       L +  QK  E   E+E  
Sbjct: 1427 ---LQNEVEDLMLDVERTNAACAALDKKQRNFDKI-------LAEWKQKCEETHAELEAS 1476

Query: 773  LLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALT 832
              E  SL  ++ +++  +   E+   ++  LK     L++++S+L ++  E  ++IH L 
Sbjct: 1477 QKEARSLGTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL- 1532

Query: 833  SENTNLKKMMSNQYVPVKTH-EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKN 891
                 +KK +  +   ++   EE + +L     K  R  L++ +   +++++  +  ++ 
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589

Query: 892  EILKRN----LENTQNQIKAEYIS-------LAEHEAKMSSLSQSMRKVQDSNAEILANY 940
            + LKRN    +E+ Q+ + AE  S         + E  ++ +   +       AE L NY
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649

Query: 941  RKGQ----EEIVTLHAEIKAQ---KKELDTIQECIKVKYAPI----VSFEECERKFKATE 989
            R  Q    +  + L   +++Q   K++L  ++    +  A I     + E+ ER  K  E
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709

Query: 990  KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1049
            +EL D  SE+ Q        +   K+   KL+ +I  +Q ++ D  +L E  +  E+A  
Sbjct: 1710 QELLD-ASERVQLLHTQNTSLINTKK---KLETDISQMQGEMED--ILQEARNAEEKAKK 1763

Query: 1050 RKTD------ELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1103
              TD      EL K+ +D S     +K   E+ V++   +  E  A Q  L+     +++
Sbjct: 1764 AITDAAMMAEELKKE-QDTSAHLERMKKNMEQTVKDLQLRLDE--AEQLALKGGKKQIQK 1820

Query: 1104 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL-HQLLENQKNSSVPLAEHLQIKEA 1162
            +EA  + L G +E+ ++      +   K ++ V +L +Q  E++KN    +     + + 
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN----ILRLQDLVDK 1876

Query: 1163 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1222
             + +V   K    E EE+S   + +  KLQ E++  ++     E++    ++K +    +
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ----VNKLRVKSRE 1932

Query: 1223 LETQISS 1229
            + T++ S
Sbjct: 1933 VHTKVIS 1939



 Score =  127 bits (320), Expect = 6e-29
 Identities = 187/905 (20%), Positives = 381/905 (42%), Gaps = 147/905 (16%)

Query: 570  KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNE 629
            K + ++   +KE++  + E +K   ++ + E + KEL  K+   +        K+ L  +
Sbjct: 843  KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE------KNDLQLQ 896

Query: 630  VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELG 689
            V  +A+ L + E   ++ +    QL+ +++ V  +       E+ E++ + L  K  +L 
Sbjct: 897  VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA------EDEEEINAELTAKKRKLE 950

Query: 690  KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIID 749
             + +EL       +K+I+ + L    ++++ H    ++KN      ++E+M     A +D
Sbjct: 951  DECSEL-------KKDIDDLELTLAKVEKEKHATENKVKN------LTEEM-----AGLD 992

Query: 750  DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVE 809
            +   KL        EKK   E      D L  +  ++ T+     K E+++  L+ ++ +
Sbjct: 993  ETIAKLT------KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1046

Query: 810  LKK---QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT 866
             KK    L   K+K   D +    L  E+             +   E  K  L++ L K 
Sbjct: 1047 EKKLRMDLERAKRKLEGDLK----LAQES-------------IMDIENEKQQLDEKLKKK 1089

Query: 867  NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM 926
              E+ +++ K ED     ++++ K + L+  +E  + +I+AE  S A+ E + S LS+ +
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149

Query: 927  RKVQD--------SNAEILANYRKGQE--------EIVTLHAEIKA---QKKELDTIQEC 967
             ++ +        ++A+I  N ++  E        E  TL  E  A   +KK  D++ E 
Sbjct: 1150 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1209

Query: 968  --------------------IKVKYAPIVSFEECERKFKATEKE----LKDQLSEQTQKY 1003
                                +K++   + S  E   K K   ++    L+DQLSE   K 
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269

Query: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD-- 1061
               +  +     +  +L+ E     + L +K  L+ +    ++A +++ +EL +QL++  
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329

Query: 1062 -------------------LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP-L 1101
                               L ++Y E +  K +L    +K  +E+   +   +   +   
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 1102 EQVEALKKSLNGTIENLKEELKSMQ-RCYEKE---QQTVTKLHQLLENQKNSSVPLAEHL 1157
            E++E  KK L   ++  +E ++++  +C   E   Q+   ++  L+ + + ++   A   
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 1158 QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1217
            + +  F+K +   K    E   E +   +E   L +E+   K A ++     +  L   K
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE----SLDQLETLK 1505

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
                +L+ +IS L E++A   ++  E     L   KK++  + EK  L  ++E+     +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKCELQAALEEAEASLE 1558

Query: 1278 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1337
                K L    EL +   E  ++I  KD +I +L  +  R+ +++         S N   
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI 1618

Query: 1338 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------EDVQE 1389
            R   L   ++  +  +E QL  A+R   E +  YR    +L   Q H+D      ED++E
Sbjct: 1619 R---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675

Query: 1390 ALLQI 1394
             L  +
Sbjct: 1676 QLAMV 1680



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 134/795 (16%), Positives = 315/795 (39%), Gaps = 50/795 (6%)

Query: 200  RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSL 259
            RD  E  +++ A  + L     DS   A +G+ +D L  +K   E      ++     + 
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

Query: 260  QQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLN 319
                ++  +  +       E Q + +L+ + E+ +  +  +  ++  L  +      QL+
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298

Query: 320  EEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 379
            E+  +   L   ++     +   ++Q EE ++   AL +  +    D       +   +E
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 380  DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 439
                 Q  +  A+++          ++ ++ R  EL    +      +  ++ +EA+   
Sbjct: 1359 SKAELQRALSKANTEVAQ--WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAK 1416

Query: 440  CESAKQDRLKLQNELAHKVAECKALALEC---ERVKEDSDEQIKQLEDALKDVQKRMYES 496
            C S ++ + +LQNE+   + + +     C   ++ + + D+ + + +   ++    +  S
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476

Query: 497  EGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
            + + + + T    +K               EE  DQL+ LK + +    E+  L  QI +
Sbjct: 1477 QKEARSLGTELFKIKNAY------------EESLDQLETLKRENKNLQQEISDLTEQIAE 1524

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA 616
                + E ++ + ++ +E   LQ  L   E   E +  K+  ++ +  ++ +++   I A
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-A 1583

Query: 617  EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ 676
            EK E +     N +         ++ E       IR LK+++E    ++   +       
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHANRMA 1642

Query: 677  VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKV 736
             ++    ++ +   K T++ L +    +E  K  L   +++ +A+ L  E++     L+ 
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQL--AMVERRANLLQAEIEELRATLEQ 1700

Query: 737  SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH 796
            +E  +K  +       ++LLD +++       ++ L  +N SL     +LET     +  
Sbjct: 1701 TERSRKIAE-------QELLDASER-------VQLLHTQNTSLINTKKKLETDISQMQGE 1746

Query: 797  EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY--VPVKTHEE 854
             ++I+    N  E  K+         E+ +K    ++    +KK M      + ++  E 
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806

Query: 855  VKMTLN------DTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAE 908
             ++ L         L    REL    +  +  N E VK   K+E   + L     + +  
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866

Query: 909  YISLAEH----EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTI 964
             + L +     +AK+ S  +   + ++ +   LA +RK Q E+          + +++ +
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926

Query: 965  QECIKVKYAPIVSFE 979
            +   +  +  ++S E
Sbjct: 1927 RVKSREVHTKVISEE 1941


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  170 bits (430), Expect = 1e-41
 Identities = 247/1063 (23%), Positives = 463/1063 (43%), Gaps = 171/1063 (16%)

Query: 430  KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
            K +LEA         +D  ++  EL    A+ + L  EC  +K+D D+    LE  L  V
Sbjct: 916  KIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD----LELTLAKV 968

Query: 490  QKRMYESEGKVKQMQTHFLALKE---HLTSE--AASGNHRLT-------EELKDQLKDLK 537
            +K  + +E KVK +      L E    LT E  A    H+ T       E+  + L   K
Sbjct: 969  EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028

Query: 538  VKYEGASAEVGKLRNQIKQNEMIVEEFKR------------------DEGKLIEENKRLQ 579
            +K E    ++     Q K+  M +E  KR                  D+ +L E+ K+ +
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE 1088

Query: 580  KELSMCEMEREKKGRKVTEMEGQAKELSAK---LALSIPAE-----KFENMKSSLSNEVN 631
             E+S  + + E +     +++ + KEL A+   L   I AE     K E  +S LS E+ 
Sbjct: 1089 FEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148

Query: 632  EKAKKL----------VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 681
            E +++L          +EM ++ E   +E ++++R+LE             +HE   + L
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKRE---AEFQKMRRDLEEATL---------QHEATAATL 1196

Query: 682  EQKSG----ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 737
             +K      ELG++I  L    Q L+KE  ++ ++   L      ++    N     +  
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRAL 1256

Query: 738  EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEM---EKLLLENDSLSKDVSRLETVFVPPE 794
            ED         ++  R + D+T +    + E     + L E D+L   +SR +  F    
Sbjct: 1257 EDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT--- 1313

Query: 795  KHEKEIIALKSNIVELKKQLSE-LKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHE 853
                        I ELK+QL E +K K        HAL S   +   ++  QY   +  +
Sbjct: 1314 ----------QQIEELKRQLEEEIKAKSA----LAHALQSSRHDCD-LLREQY---EEEQ 1355

Query: 854  EVKMTLNDTLAKTNRELLDVKKKFE-DINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 912
            E K  L   ++K N E+   + K+E D  Q   ++++  + L + L++ +  ++A     
Sbjct: 1356 EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415

Query: 913  AEHEAKMSSLSQS----MRKVQDSNA-------------EILANYRKGQEEIVTLHAEIK 955
            A  E     L       M  V+ +NA             +ILA +++  EE    HAE++
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET---HAELE 1472

Query: 956  AQKKELDTIQ-ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1014
            A +KE  ++  E  K+K A   S ++ E   K   K L+ ++S+ T++ +    E  K  
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIA----EGGKRI 1527

Query: 1015 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA-LSRKTDELNKQLKDLSQKYTEVKNVK 1073
             E +K+KK++   + +L+      E S E E   + R   ELN+   ++ +K  E    K
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE----K 1583

Query: 1074 EKLVEENAKQTSEIL-AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKE 1132
            ++ +++  +    I+ ++Q+ L  +         LKK + G +  ++ +L    R   + 
Sbjct: 1584 DEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643

Query: 1133 QQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQ 1192
             +       +L   K++ + L + L+ +E  ++++ ++       E  +     E+ +L+
Sbjct: 1644 LRNYRNTQAIL---KDTQLHLDDALRSQEDLKEQLAMV-------ERRANLLQAEIEELR 1693

Query: 1193 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL----ANLNRKYEEVCEEV 1248
            + ++ T+++ +K+  +E++D S+         T + +  +KL    + +  + E++ +E 
Sbjct: 1694 ATLEQTERS-RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEA 1752

Query: 1249 LHAKKKEISAKDEKELLHFSI--EQEIKDQKERCDKSLT-TITELQRRIQESA------- 1298
             +A++K   A  +  ++   +  EQ+     ER  K+L  T+ +LQ R+ E+        
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812

Query: 1299 -KQIEAKDNKITELLNDVE----RLKQALNGL-------SQLTYTSGNPTK---RQSQLI 1343
             KQI+  + ++ EL  +VE    R  +A+ GL        +LTY +    K   R   L+
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLV 1872

Query: 1344 DTLQHQVKSLEQQLADADRQHQEVIAIYR--THLLSAAQGHMD 1384
            D LQ +VKS ++Q  +A+ Q    ++ +R   H L  A+   D
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERAD 1915



 Score =  149 bits (377), Expect = 1e-35
 Identities = 202/1028 (19%), Positives = 448/1028 (43%), Gaps = 112/1028 (10%)

Query: 231  DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 286
            D+L+ LTL K   E     NK + L ++   L +      +++   K+ Q  HQ  + DL
Sbjct: 959  DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLDDL 1014

Query: 287  EIENEDLKERLR-KIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ 345
            + E + +    + KI+ EQ+     V+ L+  L +E  +  DLE  + KL+  L   ++ 
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQ-----VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069

Query: 346  HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQ 405
              +     + L  + K  E +  G  S   +  E  L  Q Q  + + Q     +   ++
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIED--EQALGMQLQKKIKELQARIEELEEEIE 1127

Query: 406  SRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL------KLQNELAHKVA 459
            +    R       S  S    EI ++  EA        + ++       K++ +L     
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187

Query: 460  ECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA 519
            + +A A    +   DS  ++ +  D L+ V++++ + + ++K M+   LA      S+A 
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK-MEIDDLASNMETVSKAK 1246

Query: 520  SGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ 579
                ++   L+DQL ++K K E    E  +L N +      ++    +  + ++E   L 
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEE----EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLV 1302

Query: 580  KELSMCEMEREKKGRKVTEMEGQAKE-LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLV 638
             +LS     ++   +++ E++ Q +E + AK AL+   +   +    L  +  E+ +   
Sbjct: 1303 SQLSR---GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 639  EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 698
            E++R   K+ SE+ Q + + E    +     + EE E+ K +L Q+  +  + +  +  K
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414

Query: 699  NQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV 758
              +L+K  ++       L+ +  +L I+++         +  +++ D I       L + 
Sbjct: 1415 CASLEKTKQR-------LQNEVEDLMIDVERTNAACAALDKKQRNFDKI-------LAEW 1460

Query: 759  TQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELK 818
             QK  E   E+E    E+ SLS ++ +++  +   E+   ++  LK     L++++S+L 
Sbjct: 1461 KQKCEETHAELEASQKESRSLSTELFKIKNAY---EESLDQLETLKRENKNLQQEISDLT 1517

Query: 819  KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 878
            ++  E  ++IH L      +++  S     +   EE + +L     K  R  L++ +   
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAAL---EEAEASLEHEEGKILRIQLELNQVKS 1574

Query: 879  DINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAEH-------EAKMSSLSQSMR 927
            +++++  +  ++ + +KRN    +E+ Q+ + AE  S  +        E  ++ +   + 
Sbjct: 1575 EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1634

Query: 928  KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKA 987
                  AE L NYR  Q       A +K  +  LD                         
Sbjct: 1635 HANRMAAEALRNYRNTQ-------AILKDTQLHLDDALR--------------------- 1666

Query: 988  TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERA 1047
            ++++LK+QL+   ++ ++ + E+++ +   ++ ++     +++L D +  ++  H    +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726

Query: 1048 LSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1107
            L     +L   +  +  +  ++        E+  K  ++   +   L+K+      +E +
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786

Query: 1108 KKSLNGTIENLKEE--------LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQI 1159
            KK+L  T+++L+          LK  ++  +K +  V +L   +E+++  +V   + L+ 
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRK 1846

Query: 1160 KEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQSEVQNTKQALKKLETREVVDLSKY 1216
             E   KE+        + EE+ +N +   + V KLQ++V++ K+  ++ E +  V+LSK+
Sbjct: 1847 HERKVKEL------TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKF 1900

Query: 1217 KATKSDLE 1224
            +  + +LE
Sbjct: 1901 RRIQHELE 1908



 Score =  135 bits (341), Expect = 2e-31
 Identities = 206/910 (22%), Positives = 384/910 (42%), Gaps = 157/910 (17%)

Query: 570  KLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK----------LALSIPAE-- 617
            K + ++   +KE++  + E EK   ++ + E + KEL  K          L L + AE  
Sbjct: 841  KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 618  -------------KFENMKSSLSNEVNEKAKKLVEMERE----HEKSLSEIRQLKRELEN 660
                         K +    +   EV E+A+   E+  E      K   E  +LK+++++
Sbjct: 901  SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960

Query: 661  VKAKLAQHVKPEEH---EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLK 717
            ++  LA+ V+ E+H    +VK+  E+ +G L + I +LT + + LQ+  ++   D +  +
Sbjct: 961  LELTLAK-VEKEKHATENKVKNLTEEMAG-LDETIAKLTKEKKALQEAHQQTLDDLQAEE 1018

Query: 718  EQAHNLT----------------------IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 755
            ++ + LT                      I M       K+  D+K + ++ +D  N K 
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK- 1077

Query: 756  LDVTQKYTEKKLEMEKL--LLEND-----SLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
              + +K  +K+ EM  L   +E++      L K +  L+      E+ E+EI A +++  
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI---EELEEEIEAERASRA 1134

Query: 809  ELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865
            + +KQ S+L ++  E  E++      TS    + K    ++  ++   E     ++  A 
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 866  TNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 925
            T      ++KK  D   E  +  D  + +K+ LE  ++++K E   LA +   +S    +
Sbjct: 1195 T------LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248

Query: 926  MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 985
            + K+  +  + L+  +  +EE   L  ++ AQ+  L T               E  E   
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQT---------------ESGEYSR 1293

Query: 986  KATEKE-LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI-FTLQKDLRDKTVLIEK--- 1040
            +  EK+ L  QLS   Q ++   EE+K+  +E  K K  +   LQ    D  +L E+   
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353

Query: 1041 ----SHEMERALSRKTDEL----NKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQN 1092
                  E++RA+S+   E+     K   D  Q+  E++  K+KL +              
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR------------- 1400

Query: 1093 LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVP 1152
             LQ     +E V A   SL  T + L+ E++ +    E+       L    + Q+N    
Sbjct: 1401 -LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD---KKQRNFDKI 1456

Query: 1153 LAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD 1212
            LAE  Q  E          A L   ++ES++   E+ K+++  +   ++L +LET     
Sbjct: 1457 LAEWKQKCEE-------THAELEASQKESRSLSTELFKIKNAYE---ESLDQLET----- 1501

Query: 1213 LSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQE 1272
                K    +L+ +IS L E++A   ++  E     L   KK++  + EK  L  ++E+ 
Sbjct: 1502 ---LKRENKNLQQEISDLTEQIAEGGKRIHE-----LEKIKKQV--EQEKSELQAALEEA 1551

Query: 1273 IKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTS 1332
                +    K L    EL +   E  ++I  KD +I ++  +  R+ +++         S
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611

Query: 1333 GNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT--HLLSAAQGHMD------ 1384
             N   R   L   ++  +  +E QL  A+R   E +  YR    +L   Q H+D      
Sbjct: 1612 RNDAIR---LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668

Query: 1385 EDVQEALLQI 1394
            ED++E L  +
Sbjct: 1669 EDLKEQLAMV 1678



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 103/530 (19%), Positives = 224/530 (42%), Gaps = 82/530 (15%)

Query: 872  DVKKKFEDINQ------EFVKIKDKNEILKRNLENTQNQ---------IKAEYISLAEHE 916
            D K++++ +N       +F+  K  +E L  +++    Q          KA  + L E E
Sbjct: 721  DFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLE-E 779

Query: 917  AKMSSLSQSMRKVQDSNAEILAN--YRK---GQEEIVTLHAEIKA--QKKELDTIQECIK 969
             +   L+Q + + Q      LA   Y+K    +E I  +   ++A    K    ++   K
Sbjct: 780  MRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFK 839

Query: 970  VKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQK 1029
            +K  P++   E       TEKE+ +   E    +  ++EE+ K + +  +L++++ TL +
Sbjct: 840  IK--PLLKSAE-------TEKEMANMKEE----FEKTKEELAKTEAKRKELEEKMVTLMQ 886

Query: 1030 DLRDKTVLIEKSHEMERALSRKTDELNK-------QLKDLSQKYTEVKNVKEKLVEENAK 1082
            +  D  + ++   +       + D+L K       ++K+++++  + + +  +L  +  K
Sbjct: 887  EKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946

Query: 1083 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1142
               E   ++  +    + L +VE  K +    ++NL EE+  +        +T+ KL + 
Sbjct: 947  LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-------DETIAKLTKE 999

Query: 1143 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQAL 1202
             +  + +     + LQ +E     +   K  L ++ ++ +  +E+  K++ +++  K+ L
Sbjct: 1000 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL 1059

Query: 1203 KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1262
            +        DL   + +  D+E     L+EKL                 KKKE       
Sbjct: 1060 EG-------DLKLAQESTMDIENDKQQLDEKL-----------------KKKEFEMS--- 1092

Query: 1263 ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322
                  ++ +I+D++    +    I ELQ RI+E  ++IEA+     +       L + L
Sbjct: 1093 -----GLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147

Query: 1323 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
              +S+    +G  T  Q ++    + + + + + L +A  QH+   A  R
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 78/376 (20%), Positives = 158/376 (42%), Gaps = 54/376 (14%)

Query: 262  RNLTHMQDEVNV--KSHQREHQNIQ---DLEIENEDLKERLRKIQQEQRILLDKVNGLQL 316
            R +    +E++   ++H R  +++Q   D EI + +   RL+K  +        +N +++
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD------LNEMEI 1631

Query: 317  QLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSN 376
            QLN    +A +        +++L   +   +++LR+ E LK +    E            
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE------------ 1679

Query: 377  RKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRP--LELSLPSQTSYSENEIL---KK 431
            R+ ++L  + +   A  + T        +SR +     L+ S   Q  +++N  L   KK
Sbjct: 1680 RRANLLQAEIEELRATLEQTE-------RSRKIAEQELLDASERVQLLHTQNTSLINTKK 1732

Query: 432  ELEAMRTFCESAKQDRLKLQNELAHKVAECKA-LALECERVKEDSDEQI------KQLED 484
            +LE   +  +   +D ++       K  +     A+  E +K++ D         K LE 
Sbjct: 1733 KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792

Query: 485  ALKDVQKRMYESE-----GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QL 533
             +KD+Q R+ E+E     G  KQ+Q     ++E L  E  S   R  E +K       ++
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE-LEGEVESEQKRNVEAVKGLRKHERKV 1851

Query: 534  KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 593
            K+L  + E     + +L++ + + +  V+ +KR   +  E++     +    + E E+  
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911

Query: 594  RKVTEMEGQAKELSAK 609
             +    E Q  +L  K
Sbjct: 1912 ERADIAESQVNKLRVK 1927


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  166 bits (421), Expect = 1e-40
 Identities = 263/1182 (22%), Positives = 505/1182 (42%), Gaps = 180/1182 (15%)

Query: 250  RELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLD 309
            R   K  P LQ   +T  ++E+  K  +      +  ++E E L+E  RK QQ    LL+
Sbjct: 836  RVFTKVKPLLQ---VTRQEEELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQ----LLE 887

Query: 310  KVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL----KNRFKYFES 365
            + N L  QL  E     +L +E E++++ LAAK+++ EE L  +E+     + R +  ++
Sbjct: 888  EKNILAEQLQAET----ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQN 943

Query: 366  DHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSE 425
            +     +H  + +E +  ++G    A  +     + A  + + M   + L L  Q S   
Sbjct: 944  EKKKMQAHIQDLEEQLDEEEG----ARQKLQLEKVTAEAKIKKMEEEI-LLLEDQNSKFI 998

Query: 426  NEILKKELEAMRTFC-------ESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQ 478
             E  KK +E     C       E   ++  K++N+    +++ +    + E+ +++ ++ 
Sbjct: 999  KE--KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056

Query: 479  IKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNH---------RLTEEL 529
             ++L+    D+Q ++ E + ++ +++      +E L    A G+          ++  EL
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116

Query: 530  KDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-----EGKLIEENKRLQKELSM 584
            + Q+ +L+  +E   A   K   Q +     +E  K +     +    ++  R ++E  +
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176

Query: 585  CEM----EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 640
             E+    E E K  +    + + +  +A   LS   E+ +  K++L     EK K+ +E 
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL-----EKNKQGLET 1231

Query: 641  E-REHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKN 699
            + +E    +  ++Q+K E E+ + KL   V+          L  K  E  +   EL  K 
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQ---------ELHAKVSEGDRLRVELAEKA 1282

Query: 700  QTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVT 759
              LQ E++ V      L E+A    I+       L   E   +    ++ +  R+ L+++
Sbjct: 1283 SKLQNELDNV----STLLEEAEKKGIKFAKDAASL---ESQLQDTQELLQEETRQKLNLS 1335

Query: 760  QKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKK 819
             +   ++LE EK  L+     ++ +R        +  EK+++AL+S       QL++ KK
Sbjct: 1336 SRI--RQLEEEKNSLQEQQEEEEEAR--------KNLEKQVLALQS-------QLADTKK 1378

Query: 820  KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 879
            K  +D   I +L       KK +      +    E K    D L KT   L   +++ +D
Sbjct: 1379 KVDDDLGTIESLEEA----KKKLLKDAEALSQRLEEKALAYDKLEKTKNRL---QQELDD 1431

Query: 880  INQEFVKIKDKNEILKRNLENTQ---NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI 936
            +  +     D    +  NLE  Q   +Q+ AE  S++   A+    +++  + +++ A  
Sbjct: 1432 LTVDL----DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487

Query: 937  LANYRKGQEEIVTLHAEIKAQKKELDT-IQECIKVKYAPIVSFEECERKFKATEK---EL 992
            LA   +  EE +    E + Q K+L   +++ +  K     +  E E+  +A E+   E+
Sbjct: 1488 LA---RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544

Query: 993  KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMER 1046
            + QL E   +   +E+  K   + N +  K  F      RD      K +LI++  E+E 
Sbjct: 1545 RTQLEELEDELQATED-AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA 1603

Query: 1047 AL------------SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLL 1094
             L            S+K  E++  LKDL  +       +++++++  K  +++   Q  L
Sbjct: 1604 ELEDERKQRALAVASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661

Query: 1095 QKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1147
            ++     +++       E   KSL   I  L+EEL S +R     +Q   +L   + N  
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 1148 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME-----------EVSKLQSEV- 1195
            +    L +    K   E  +    A L E+ EE Q+ ME           +V  L +E+ 
Sbjct: 1722 SGKSALLDE---KRRLEARI----AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774

Query: 1196 ---------QNTKQALK--------KLETREVVDLSKYKATKSDLETQISSLNEKLANLN 1238
                      N +Q L+        KL+  E    SK+KAT S LE +I  L E+L    
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834

Query: 1239 RKYEEVCEEVLHAKKK--EISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1296
            ++     + V   +KK  EI  + E E  H     + K+Q E   K+   + +L+R+++E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRH---ADQYKEQME---KANARMKQLKRQLEE 1888

Query: 1297 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKR 1338
            + ++    +    +L  +++   +A  GLS+   T  N  +R
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930



 Score =  150 bits (380), Expect = 6e-36
 Identities = 213/993 (21%), Positives = 409/993 (41%), Gaps = 133/993 (13%)

Query: 432  ELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQK 491
            ELE M    E   Q  L+ +N LA ++     L  E E ++     + ++LE+ L D++ 
Sbjct: 874  ELEEM----ERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929

Query: 492  RMYESE-------GKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGAS 544
            R+ E E        + K+MQ H   L+E L  E  +      E++  + K  K++ E   
Sbjct: 930  RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989

Query: 545  AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENK--------RLQKELSMCEMEREKKGRKV 596
             E  +    IK+ +++ +       +L EE +        R ++E+ + ++E   K  + 
Sbjct: 990  LE-DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048

Query: 597  TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMERE--------HEKSL 648
            T  E +     AK  L       ++  + L  +++E   +L + E E         +++L
Sbjct: 1049 TRQELE----KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETL 1104

Query: 649  SEIRQLK--RELENVKAKLAQHVKPEEHEQVKSRLEQK--SGELGKKITEL--TLKNQTL 702
             +   LK  REL+   A+L +  + E+  + K+  +++  S EL    TEL  TL     
Sbjct: 1105 HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA 1164

Query: 703  QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 762
            Q+E          L+ +      E+K      K  E+  K+H+A I D+ ++     ++ 
Sbjct: 1165 QQE----------LRTKREQEVAELK------KALEEETKNHEAQIQDMRQRHATALEEL 1208

Query: 763  TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 822
            +E +LE  K    N  L K+   LET         KE+      + ++K +    +KK  
Sbjct: 1209 SE-QLEQAKRFKAN--LEKNKQGLET-------DNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 823  EDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 882
               +++HA  SE                  + +++ L +  +K   EL +V    E+  +
Sbjct: 1259 AQVQELHAKVSEG-----------------DRLRVELAEKASKLQNELDNVSTLLEEAEK 1301

Query: 883  EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 942
            + +K       L+  L++TQ  ++ E        +++  L +    +Q+   E     + 
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361

Query: 943  GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK 1002
             +++++ L +++   KK++D            I S EE ++K     + L  +L E+   
Sbjct: 1362 LEKQVLALQSQLADTKKKVDD-------DLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414

Query: 1003 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT---DELNKQL 1059
            Y              DKL+K    LQ++L D TV ++   ++   L +K    D+L  + 
Sbjct: 1415 Y--------------DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460

Query: 1060 KDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLK 1119
            K +S +Y E ++  E   E   K+T + L++   L++     E+ E   K L   +E+L 
Sbjct: 1461 KSISARYAEERDRAE--AEAREKET-KALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517

Query: 1120 EELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE----AFEKEVGIIKA--- 1172
                 + +   + +++   L Q +E  +     L + LQ  E      E  +  +KA   
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577

Query: 1173 -SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLN 1231
              L+ ++E+++ K   + K   E++   +  +K     V    K +    DLE QI + N
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637

Query: 1232 E----------KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCD 1281
            +          KL    + Y+   EE   ++ +  +   E E    S+E EI   +E   
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697

Query: 1282 KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL------SQLTYTSGNP 1335
             S       ++   E A +I    +  + LL++  RL+  +  L       Q      N 
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 1336 TKRQSQL-IDTLQHQVKSLEQQLADADRQHQEV 1367
              R++ L +DTL  ++ +       +D   Q++
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790



 Score =  146 bits (368), Expect = 2e-34
 Identities = 221/1087 (20%), Positives = 453/1087 (41%), Gaps = 142/1087 (13%)

Query: 277  QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKL- 335
            Q   + + DLE   E+ +ER + +Q E++ +   +  L+ QL+EE       E  R+KL 
Sbjct: 918  QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-------EGARQKLQ 970

Query: 336  --KSLLAAKEKQHEESLRTIEALKNRF----KYFESDHLGSGSHFSNRKEDM-----LLK 384
              K    AK K+ EE +  +E   ++F    K  E       S  +  +E       +  
Sbjct: 971  LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 385  QGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEIL--------------K 430
            + ++ ++D +     +    ++R  L   +  L  +T+  +++I               K
Sbjct: 1031 KQEVMISDLE---ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087

Query: 431  KELEAMRTFCESA-----KQDRLKLQNELAHKVAEC-------KALALECERVKEDSDEQ 478
            KE E              K + LK+  EL  ++AE        KA   + E+ K D  E+
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147

Query: 479  IKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV 538
            ++ L+  L+D        +    + +     LK+ L  E        T+  + Q++D++ 
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--------TKNHEAQIQDMRQ 1199

Query: 539  KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTE 598
            ++  A  E   L  Q++Q +      ++++  L  +NK L  E+ + +  + +   K  +
Sbjct: 1200 RHATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256

Query: 599  MEGQAKELSAKLA--------LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREH---EKS 647
            ++ Q +EL AK++        L+  A K +N   ++S  + E  KK ++  ++    E  
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316

Query: 648  LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITE---LTLKNQTLQK 704
            L + ++L +E    K  L+  ++  E E+   + +Q+  E  +K  E   L L++Q    
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376

Query: 705  E---------IEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 755
            +         IE +    K L + A  L+  ++   +     E  K      +DDL   L
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436

Query: 756  ---LDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALK-----SNI 807
                 V     +K+ + ++LL E  S+S   +  E      E  EKE  AL         
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRAEAEAREKETKALSLARALEEA 1495

Query: 808  VELKKQLSELKKKCGEDQE-----------KIHALTSENTNLKKMMSNQYVPVKTHEEVK 856
            +E K++     K+   D E            +H L      L++ +      ++  E+  
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555

Query: 857  MTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 916
                D   +    +  +K +FE   ++     ++NE  KR L     +++AE     E E
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFE---RDLQTRDEQNEEKKRLLIKQVRELEAEL----EDE 1608

Query: 917  AKMSSLSQSMRK-----VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT-IQECIKV 970
             K  +L+ + +K     ++D  A+I A   K ++E++    +++AQ K+    ++E    
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAA-NKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667

Query: 971  KYAPIVSFEECERKFKATEKE---LKDQL--SEQTQKYSVSEEEVKKNK----------- 1014
            +       +E E+K K+ E E   L+++L  SE+ ++++  E +   ++           
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727

Query: 1015 -QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK 1073
              E  +L+  I  L+++L ++   +E  ++  R  + + D LN +L        +  N +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787

Query: 1074 EKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQ 1133
            ++L  +N +  +++  ++  ++ +      + AL+  +    E L++E K      +  +
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKAT--ISALEAKIGQLEEQLEQEAKERAAANKLVR 1845

Query: 1134 QTVTKLHQL---LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK 1190
            +T  KL ++   +E+++  +    E ++   A  K+   +K  L E EEE+        K
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ---LKRQLEEAEEEATRANASRRK 1902

Query: 1191 LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLH 1250
            LQ E+ +  +A + L +REV  L         +    S    +  +L     E+ ++   
Sbjct: 1903 LQRELDDATEANEGL-SREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTE 1961

Query: 1251 AKKKEIS 1257
            +K  +++
Sbjct: 1962 SKTSDVN 1968



 Score =  130 bits (328), Expect = 7e-30
 Identities = 178/929 (19%), Positives = 402/929 (43%), Gaps = 123/929 (13%)

Query: 532  QLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK 591
            Q ++L+ K E    E+ K++ +  + E  +EE +R   +L+EE   L ++L         
Sbjct: 850  QEEELQAKDE----ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL--------- 896

Query: 592  KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 651
              +  TE+  +A+E+ A+LA     ++ E +   L + V E+ ++   ++ E +K  + I
Sbjct: 897  --QAETELFAEAEEMRARLAAK--KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952

Query: 652  RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 711
            + L+ +L+            EE  + K +LE+ + E   KI ++  +   L+ +  K   
Sbjct: 953  QDLEEQLDE-----------EEGARQKLQLEKVTAEA--KIKKMEEEILLLEDQNSKFIK 999

Query: 712  DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
            + KL++++    + ++       K    ++   + +I DL  +L    ++ T ++LE  K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEKAK 1057

Query: 772  LLLEN------DSLSKDVSRLETVFVPPEKHEKEIIAL----------KSNIVELKKQLS 815
              L+       D +++  ++++ + +   K E+E+             K+N +++ ++L 
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117

Query: 816  ELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA------KTNRE 869
                +  ED E   A  ++    K+ +S +   +KT  E++ TL+ T A      K  +E
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT--ELEDTLDTTAAQQELRTKREQE 1175

Query: 870  LLDVKKKFEDINQEF-VKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRK 928
            + ++KK  E+  +    +I+D  +     LE    Q++      A  E     L    ++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 929  V-------QDSNAEILANYRKGQEEIVTLHAEI------------KAQK--KELDTIQEC 967
            +       Q   AE     +K   ++  LHA++            KA K   ELD +   
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 968  IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1027
            ++      + F +     ++  ++ ++ L E+T++       +++ ++E + L+++    
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ--- 1352

Query: 1028 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI 1087
                       E+  E  + L ++   L  QL D  +K  +     E L E   K   + 
Sbjct: 1353 -----------EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401

Query: 1088 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1147
             A+   L+++ +  +++E  K  L   +++L  +L   ++     ++   K  QLL  +K
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461

Query: 1148 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1207
            + S   AE     EA  +E      SL    EE+    EE  +   +++   + L   + 
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521

Query: 1208 REVVDLSKYKATKSDLETQISSLNEKLANLNRKYE---------EVCEEVLHAK-KKEIS 1257
                ++ + + +K  LE Q+  +  +L  L  + +         EV  + + A+ ++++ 
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581

Query: 1258 AKDE-----KELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1309
             +DE     K LL   +   E E++D++++   ++ +  +++  +++   QIEA +    
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARD 1641

Query: 1310 ELLNDVERLKQALNGLS-QLTYTSGN------PTKRQSQLIDTLQHQVKSLEQQLADADR 1362
            E++  + +L+  +     +L     +       +K   + + +L+ ++  L+++LA ++R
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701

Query: 1363 ------QHQEVIAIYRTHLLSAAQGHMDE 1385
                  Q ++ +A   T+  S     +DE
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDE 1730



 Score =  108 bits (270), Expect = 4e-23
 Identities = 142/689 (20%), Positives = 310/689 (44%), Gaps = 85/689 (12%)

Query: 679  SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSE 738
            +R E++     +++ ++  K   ++ E+E++   ++ L E+ + L  +++        +E
Sbjct: 848  TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907

Query: 739  DMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEK 798
            +M+    A   +L   L D+  +  E++   + L  E   +   +  LE      E+ ++
Sbjct: 908  EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE------EQLDE 961

Query: 799  EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 858
            E  A +   ++L+K  +E K K  + +E+I  L  +N+   K               K  
Sbjct: 962  EEGARQK--LQLEKVTAEAKIK--KMEEEILLLEDQNSKFIK--------------EKKL 1003

Query: 859  LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAK 918
            + D +A+ + +L + ++K +++     KI++K E++  +LE            L + E  
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNL----AKIRNKQEVMISDLEE----------RLKKEEKT 1049

Query: 919  MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSF 978
               L ++ RK+     ++       Q++I  L A+I   K +L   +E  +++ A     
Sbjct: 1050 RQELEKAKRKLDGETTDL-------QDQIAELQAQIDELKLQLAKKEE--ELQGALARGD 1100

Query: 979  EECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDK--LKKEIFTLQKDLRDK 1034
            +E   K  A +  +EL+ Q++E  + +    E+  +NK E  K  L +E+  L+ +L D 
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDF--ESEKASRNKAEKQKRDLSEELEALKTELEDT 1158

Query: 1035 TVLIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEK---LVEENAKQTSEILAV 1090
                    E+     ++  EL K L++ ++ +  ++++++++    +EE ++Q  +    
Sbjct: 1159 LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRF 1218

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            +  L+K     + +E   K L   ++ L++     +   +K    V +LH  +       
Sbjct: 1219 KANLEKNK---QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
            V LAE        + E+  +   L E E++     ++ + L+S++Q+T++ L++ ETR+ 
Sbjct: 1276 VELAEK---ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE-ETRQ- 1330

Query: 1211 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
                     K +L ++I  L E+  +L  + EE         ++E     EK++L  +++
Sbjct: 1331 ---------KLNLSSRIRQLEEEKNSLQEQQEE---------EEEARKNLEKQVL--ALQ 1370

Query: 1271 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1330
             ++ D K++ D  L TI  L+   ++  K  EA   ++ E     ++L++  N L Q   
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 1331 TSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1359
                    Q Q+   L+ + K  +Q LA+
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 141/657 (21%), Positives = 283/657 (43%), Gaps = 69/657 (10%)

Query: 227  ARIGDNLD-ILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREH--QNI 283
            +++ + LD + TLL+ A +   KG +  K   SL+ + L   Q+ +  ++ Q+ +    I
Sbjct: 1283 SKLQNELDNVSTLLEEAEK---KGIKFAKDAASLESQ-LQDTQELLQEETRQKLNLSSRI 1338

Query: 284  QDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADD----LESEREKLKSLL 339
            + LE E   L+E+  + ++ ++ L  +V  LQ QL +     DD    +ES  E  K LL
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398

Query: 340  ----AAKEKQHEESLR--TIEALKNRFKY------FESDH---LGSGSHFSNRKEDMLLK 384
                A  ++  E++L    +E  KNR +        + DH   + S      +K D LL 
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458

Query: 385  QGQMYMAD-----SQCTSPGIPAHMQSRSMLRPLELSLPSQTSYS-ENEILKKELEAMRT 438
            + +   A       +  +       ++ S+ R LE +L ++  +  +N+ L+ ++E    
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME---- 1514

Query: 439  FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 498
                   D +  ++++   V E +      E+  E+   Q+++LED L+  +      E 
Sbjct: 1515 -------DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 499  KVKQMQTHF---LALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 555
             ++ M+  F   L  ++    E      +   EL+ +L+D + +   A A   K+   +K
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627

Query: 556  QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP 615
              E  +E   +   ++I++ ++LQ ++   + E E+      E+  Q+KE   KL  S+ 
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK-SLE 1686

Query: 616  AEKFENMKSSLSNEVNEKAKKLVEMER-----EHEKSLSEIRQLKRELENVKAKLAQHVK 670
            AE  +  +   S   +E+A++  E ER     E   S S    L  E   ++A++AQ  +
Sbjct: 1687 AEILQLQEELAS---SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743

Query: 671  PEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNH 730
              E EQ    L      L  +  + TL+  TL  E+      +   K       +E +N 
Sbjct: 1744 ELEEEQSNMEL------LNDRFRKTTLQVDTLNAELAAE--RSAAQKSDNARQQLERQNK 1795

Query: 731  YVPLKVSE---DMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 787
             +  K+ E    +K    A I  L  K+  + ++  +   E ++    N  + +   +L+
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ---EAKERAAANKLVRRTEKKLK 1852

Query: 788  TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 844
             +F+  E   +     K  + +   ++ +LK++  E +E+     +    L++ + +
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 87/382 (22%), Positives = 158/382 (41%), Gaps = 56/382 (14%)

Query: 1057 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1116
            K L  ++++  E++   E+L++   KQT     ++ + +K    LE+   L + L    E
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901

Query: 1117 NLKEELKSMQRCYEKEQQTVTKLH-------------QLLENQKNSSVPLAEHLQ-IKEA 1162
               E  +   R   K+Q+    LH             Q+L+N+K     +  H+Q ++E 
Sbjct: 902  LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK---MQAHIQDLEEQ 958

Query: 1163 FEKEVGI-IKASLREKEEESQNKMEEVSKLQSEVQNTKQAL-KKLETREVVDLSKYKATK 1220
             ++E G   K  L +   E++ K  E   L  E QN+K    KKL    + + S   A +
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 1221 SD-----------LETQISSLNEKLANLNRKYEEVCEEVLHAKKK-------------EI 1256
             +            E  IS L E+L    +K E+  +E+  AK+K             E+
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERL----KKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074

Query: 1257 SAK-DEKELLHFSIEQEIKDQKERCD-------KSLTTITELQRRIQESAKQIEAKDNKI 1308
             A+ DE +L     E+E++    R D        +L  + ELQ +I E  +  E++    
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134

Query: 1309 TELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVI 1368
             +       L + L  L      + + T  Q +L    + +V  L++ L +  + H+  I
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194

Query: 1369 AIYRTHLLSAAQGHMDEDVQEA 1390
               R    +A +  + E +++A
Sbjct: 1195 QDMRQRHATALE-ELSEQLEQA 1215


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score =  165 bits (417), Expect = 3e-40
 Identities = 336/1572 (21%), Positives = 637/1572 (40%), Gaps = 268/1572 (17%)

Query: 24   RLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITT 83
            ++ KAA  G+V KV  IL  +       D   R+  H+  + G+ E +  ++     +  
Sbjct: 49   KIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNV 108

Query: 84   SDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDH 143
             D   R AL  A +     C   LL++      AD+ G TALH A   +  S    L  +
Sbjct: 109  CDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168

Query: 144  GASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAV 203
             A++ AK+ D  TPL+LA    +  + + LI + A+VN+ DK   +  ++  EY      
Sbjct: 169  DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLIS-EY----KE 223

Query: 204  EVLIK------NGADISLLDAL-------GHDSSYYARIGDNLDI---------LTLLKT 241
            E + K      N  D S  D+L       G D S+     ++L+          L  L T
Sbjct: 224  ERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMT 283

Query: 242  ASENTNKGRELWKKGPSLQQRNL-----THMQDEVNVKSHQREHQNIQDLE---IENEDL 293
            AS+ + K  E          R L     +  QDEV V+S       +Q       ++ DL
Sbjct: 284  ASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDL 343

Query: 294  KER----------LRKIQQEQRILLDKVNG--------LQLQLNEEVMVADDL-ESEREK 334
              +          L K +  +  +  K NG        L+   N+ +   D++ ++ R  
Sbjct: 344  LPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSD 403

Query: 335  LKSLLAAKEKQHEESLRTIEALKNRFKYFESDHL-----GSGSHFSNRK-EDMLLKQGQM 388
            + S L   +++  ES    E++   F     D L     G   +  N + ED+      M
Sbjct: 404  MMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCM 463

Query: 389  ------YMADSQCT-SPGIP-AHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFC 440
                   MA  + T + G+P AHM+S      L+ ++  + S        K+++  +   
Sbjct: 464  SGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSK--- 520

Query: 441  ESAKQD-RLKLQNELAHKVAECKALALECERVKEDSDEQ--IKQLEDALKDVQKRMYESE 497
             +A+ D  +  + E   + +E     +E ER K  ++E      + D   D  +   + +
Sbjct: 521  -AAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDD 579

Query: 498  GKVKQMQT----HFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEV-GK--- 549
            G +++ ++    H    ++     A+SG     +E+K   K+ +   E  ++ V GK   
Sbjct: 580  GLIQKRKSGETDHQQFPRKENKEYASSGPALQMKEVKSTEKEKRTSKESVNSPVFGKASL 639

Query: 550  LRNQIKQ--NEMIVEEFKRDEGKLI-----EENKRLQKELSM----------------CE 586
            L   + Q  ++  + E   DEG+       E+NK   +  SM                CE
Sbjct: 640  LTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCE 699

Query: 587  MEREKKGRKVTEMEGQAKELSAKLAL------SIPAEKFENMKSSLSNEVNEKAKKLVEM 640
            +        +  +E    E    ++L      ++  E+   +K +    +  K KK+ + 
Sbjct: 700  LPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDK 759

Query: 641  EREHEKSLSEIRQLKRELENVKAK-------LAQHVKPEE---------HEQVKSRLEQK 684
                ++ LSE +++K +LE+ K +       L   +  EE         +E+++ +L +K
Sbjct: 760  VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 819

Query: 685  SGELGKKI---TELTLKNQTLQKEIEKVYLD-NKLLKEQ---AHNLTIE----------M 727
              +  K++    +L L  QTL+ E+  V  + N++++E+      L+ E          +
Sbjct: 820  EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGIL 879

Query: 728  KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSL-----SKD 782
             NH    K  E  +K  ++     + +  D++ K +  + E+  L LE D++      K+
Sbjct: 880  TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKE 939

Query: 783  VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
                E + +  EK+E     +K N   L + +S+          ++  LT+EN  L   +
Sbjct: 940  KKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY-------NGRLSVLTAENAMLNSKL 992

Query: 843  SNQYVPVKTHEEVKMTLNDTLA----------KTNREL-------LDVKKKFED-INQEF 884
             N+    +  E    + +  LA           + REL        D   + +D +N + 
Sbjct: 993  ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDV 1052

Query: 885  VKIKDKNEILKRNLENTQNQIKAEYI---------------------SLAEHEAKMSSLS 923
              +KD NEIL + L  T++++ +  I                      L++ + +M  + 
Sbjct: 1053 SNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEME 1112

Query: 924  QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS----FE 979
            Q  +  Q    + +      +E +  L +E    +++LD        K   +++    F 
Sbjct: 1113 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFH 1172

Query: 980  ECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ---ENDKLKKEIFT--LQKDLRD- 1033
               +K +A E E +  L E+  K  +SE    K +Q   EN+K ++E+    LQ++L D 
Sbjct: 1173 AIVQKLQA-ESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADT 1231

Query: 1034 --KTVLIEKSHEM-----------ERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080
              K  + E S E+            + L +K  ++  QL++   ++TE     EK+ +  
Sbjct: 1232 LKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHK 1291

Query: 1081 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140
             K   +   ++  ++KQ   ++++E L+K+L     NL E+        EKEQ     L 
Sbjct: 1292 QKLEKDNAKLKVTVKKQ---MDKIEELQKNLLNA--NLSED--------EKEQ-----LK 1333

Query: 1141 QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200
            +L+E +++    L + ++     E+E+   K  L+     ++ K+ E    +        
Sbjct: 1334 KLMELKQSLECNLDQEMKKNVELEREITGFKNLLK----MTRKKLNEYENGEFSFHGD-- 1387

Query: 1201 ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLH----AKKKEI 1256
             LK  +    + ++K K    DL  ++ +   K  +L+ K + + EE+L      KK E 
Sbjct: 1388 -LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEK 1446

Query: 1257 SAKDEKELLHFSIEQEIKDQKERCDKS---LTTITELQRRIQESAKQIEAKDNKITELLN 1313
              K++K+L     EQE+ + +   +++   L  + + ++ I+E A+Q  A+  K   L  
Sbjct: 1447 LQKNKKKL-----EQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1501

Query: 1314 DVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT 1373
              +   Q    L Q    +    K Q +L      ++K LE +L+      ++     +T
Sbjct: 1502 QAQAASQ--ENLEQFRENNFASMKSQMEL------RIKDLESELSKIKTSQED---FNKT 1550

Query: 1374 HLLSAAQGHMDE 1385
             L    Q +++E
Sbjct: 1551 ELEKYKQLYLEE 1562



 Score = 37.7 bits (86), Expect = 0.078
 Identities = 91/440 (20%), Positives = 166/440 (37%), Gaps = 114/440 (25%)

Query: 273  VKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESER 332
            V+  ++   + Q LE +N  LK  ++K        +DK+  LQ  L    + A+  E E+
Sbjct: 1281 VRCAEKMQDHKQKLEKDNAKLKVTVKK-------QMDKIEELQKNL----LNANLSEDEK 1329

Query: 333  EKLKSLLAAKE----------KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDML 382
            E+LK L+  K+          K++ E  R I   KN  K               RK+   
Sbjct: 1330 EQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKM-------------TRKKLNE 1376

Query: 383  LKQGQMYMADSQCTSPGIPAHMQSRSMLRPLE-LSLPSQTSYSE-------NEILKKELE 434
             + G+        TS      +Q   +   ++ L+   +T+ S+       N+IL++EL 
Sbjct: 1377 YENGEFSFHGDLKTSQ-FEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELL 1435

Query: 435  AMRTF---CESAKQDRLKLQNE--------------------------------LAHKVA 459
            +M+T    CE  ++++ KL+ E                                +A K+ 
Sbjct: 1436 SMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLK 1495

Query: 460  ECKALALECERVKEDSDEQIK---------QLEDALKDVQKRMYESEG-----------K 499
            E   L L+ +   +++ EQ +         Q+E  +KD++  + + +            K
Sbjct: 1496 EVN-LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEK 1554

Query: 500  VKQMQTHFLALKEHLTSEAASGNHRLTE----------ELKDQLKDLKVKYEGASAEVGK 549
             KQ+    L +++ L+S+    N RL E          + +     L  +       VG 
Sbjct: 1555 YKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGN 1614

Query: 550  LRNQIKQNEMIV--EEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL- 606
            L N +  N  ++  E            N  ++  LS  + E EK   +  E++  A EL 
Sbjct: 1615 LNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITR--ELKEAAAELE 1672

Query: 607  SAKLALSIPAEKFENMKSSL 626
            S  +A  + +    N+   L
Sbjct: 1673 SGSIASPLGSTDESNLNQDL 1692


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  160 bits (406), Expect = 6e-39
 Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)

Query: 254  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
            K  P LQ   +T  ++E+  K  + +    +  + ENE     L++++Q+   L ++ N 
Sbjct: 840  KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 891

Query: 314  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
            LQ QL  E     +L +E E+++  LAAK+++ EE L  +EA     +  E +  G    
Sbjct: 892  LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 942

Query: 374  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
               +K    +   +  + + +                   +L L   T+ ++ + L+ E+
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 987

Query: 434  EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 490
              M        ++R  L+   ++L   +AE +  A    ++K   +  I +LE  LK  +
Sbjct: 988  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047

Query: 491  KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 546
            K   E E            LK  L  +A S  H    +L+ Q+ +LK+    K E   A 
Sbjct: 1048 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
            + +L ++I Q    +++ +  EG + +  + L  E +      ++K     E+E    EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
               L  +   ++   +++    EV    K L E  R HE  + E+RQ             
Sbjct: 1156 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1199

Query: 667  QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 726
                  +H Q    L ++  +  +    L    QTL+KE   +  + ++L +    +   
Sbjct: 1200 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250

Query: 727  MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
                       E  KK  +A + +L  K  D  +   E   ++ KL  E +S++  ++  
Sbjct: 1251 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 787  ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 846
            E   +   K  K++ +L S + + ++ L E  ++      K+  L  E  +L+  +  + 
Sbjct: 1300 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356

Query: 847  VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 896
               +  E    TLN  L+ + ++L D           KK+F+   +   +  ++      
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 897  NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 947
             LE T+N+++ E     + L      +S+L +  RK     AE   I + Y   + + E 
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 948  VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 984
                 E KA             K+EL+   + +K +   +VS            E+ +R 
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 985  FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1026
             +   +E+K QL E   +   +E+                  +++   ++N++ +++   
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1593

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ+ L +    +E   +     +    +L   LKDL  +       +E+ +++  K  ++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 1087 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
            +   Q  L+      +++       E   KSL   +  L+E+L + +R  ++      +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713

Query: 1140 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1188
             + L +  +    L +          Q++E  E+E G ++A    +R+  ++++    E+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 1189 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1237
            +  +S  Q  + A ++LE +           E    SK+K+T + LE +I+ L E++   
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 1238 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1293
             R+ +        A  K +  KD+K    LL    E+++ +Q KE+ +K    + +L+R+
Sbjct: 1834 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885

Query: 1294 IQES---AKQIEAKDNKITELLNDVERLKQAL 1322
            ++E+   +++I A   K+   L++     +A+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAM 1917



 Score =  137 bits (344), Expect = 9e-32
 Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)

Query: 476  DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 532
            +E+++  ED L+  ++R  ++E ++K+++                 + +LTEE   L++Q
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 895

Query: 533  LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 591
            L+     Y  A AE  ++R   K+ E+  EE   + E +L EE  R Q+     + ER+K
Sbjct: 896  LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 947

Query: 592  KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 651
              +++ ++E Q +E  A        +K +  K +   ++ +   +++ M+ ++ K   E 
Sbjct: 948  MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 652  RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 711
            + L+  + ++   LA     EE E+ K+            +T+L  K++++  E+E    
Sbjct: 1002 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1041

Query: 712  DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
              +L KE+     +E             +K+  +    D + ++ D+  +  E K+++ K
Sbjct: 1042 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 772  LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 824
               + + L   ++RL+          K+I  L+ +I +L++ L       ++ +K+  + 
Sbjct: 1088 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 825  QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 880
             E++ AL +E    L    + Q +  K  +EV   K  L++       ++ ++++K    
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 881  NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 936
             +E  +  ++ +  K NL+  +  ++ E   LA     +    Q +    +K++    E+
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 937  LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
             +    G+     L+ ++   + E++++   +           E E K     K++    
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1314

Query: 997  SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1056
            S+      + +EE ++    + KL++    L+++       +++  E ++ L R    LN
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 1057 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1116
             QL D  +K  +  +  E L E   +   EI  +    +++    +++E  K  L   ++
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 1117 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1176
            +L  +L + ++     ++   K  QLL  +KN S   A+     EA  +E      SL  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
              EE+    EE+ +    ++   + L   +     ++ + + +K  LETQ+  +  +L  
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1548

Query: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1296
                 EE+ +E+   +  ++  +   + L    E++++ + E+ ++      +LQR++ E
Sbjct: 1549 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1600

Query: 1297 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1356
               ++E +  +        ++L+  L  L     ++    +   + +  LQ Q+K  +++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660

Query: 1357 LADADRQHQEVIA 1369
            L DA     E+ A
Sbjct: 1661 LEDARASRDEIFA 1673



 Score =  120 bits (300), Expect = 1e-26
 Identities = 184/928 (19%), Positives = 372/928 (40%), Gaps = 89/928 (9%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 295
            LT LK   E+     E+  K     ++ L  ++ ++   +    H+ I DL+ +  +LK 
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1083

Query: 296  RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 348
            +L K ++E +  L +++    Q N  +    +LE      +E L S  AA+   EKQ  +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 349  SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 407
                +EALK   +   +S            +E  +LK+      D +  S         +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1199

Query: 408  SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 452
               + +E               L    QT   EN  L  EL  +      AKQ+    + 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1255

Query: 453  ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 512
            +L  +V E ++   + ER + + ++++ +L++ ++ V   + E+EGK  ++     +L  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 513  HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
             L  T E      R           L EE   L+DQL +     +     +  L  Q+  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 615
            ++  +++F      L E  KR QKE+     + E+K     ++E     L  +L  L + 
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 616  AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 674
             +    + S+L  +  +  + L E +    K   E  + + E    + K     +  EE 
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495

Query: 675  EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 734
             + K  LE+ +  L  ++ +L      + K + ++    + L+ Q   +  +++     L
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555

Query: 735  KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
            + +ED K     +  A+     R L    ++  EK+ ++++ L E ++  +D  +   + 
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 791  VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
               +K         E +  +      E  KQL +L+ +  + Q ++    +    +    
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 843  SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 899
                   K+ E   M L + LA   R       + E++ +E          L   KR LE
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 900  NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 956
                Q++ E   L E +  M ++S  +RK      ++   LA  R   ++  +   +++ 
Sbjct: 1736 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 957  QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1012
            Q KEL +    ++  +K K+   ++         A E ++  QL EQ ++ +  ++   K
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1842

Query: 1013 NKQENDKLKKEIFTLQKDLRDKT----VLIEKSHEMERALSRKTDELNKQLKDLSQKYTE 1068
            + ++ DK  KEI    +D R          EK +   + L R+ +E  ++ + ++    +
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902

Query: 1069 VKNVKEKLVEENAKQTSEILAVQNLLQK 1096
            ++   ++  E N     E+ A+++ L++
Sbjct: 1903 LQRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)

Query: 971  KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1030
            K  P++     E + +A E EL+ +  E+ QK   +E E+K+ +Q++ +L +E   LQ+ 
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1031 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1090
            L+ +T L  ++ EM   L+ K  EL + L ++  +  E ++  ++L  E  K   ++L +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            +  L+++    ++++  K +    I+ L++E+  M    + +   ++K  +LLE +    
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1007

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
                  L    A E+E       L+ K E   +++E   +L+ E + ++Q L+KL+ +  
Sbjct: 1008 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1061

Query: 1211 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
             D S +    +DL+ QI+ L  +LA    K EE  +  L     EI+ K+        +E
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1117

Query: 1271 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1316
              I D +E  D       + +++ ++  +++EA   ++ + L+              +V 
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177

Query: 1317 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1365
             LK+AL+  ++         + + +Q ++ L  Q++  ++  A+ D+  Q
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)

Query: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1005
            ++     E++A++ EL   +E  +     +   E+   +    +  L++QL  +T+ Y+ 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 1006 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
            +EE    +   KQE          L++ L +    +E+  +  + L  +  ++ +Q+ DL
Sbjct: 906  AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1063 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1115
             ++  E +  ++KL  E         K   EIL + +   K     + +E     L   +
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015

Query: 1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1163
               +E+ K++ +   K +  +++L   L+ ++ S   L +            H QI +  
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1074

Query: 1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1217
            + ++  +K  L +KEEE Q     +++L  E+     ALKK+   E        DL   +
Sbjct: 1075 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
            A ++  E Q   L E+L  L  + E+  +    A ++E+ AK E+E+   ++ ++  D++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1186

Query: 1278 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
             R  ++   + E++++    ++E  +Q+E        L  + + L++    L+      G
Sbjct: 1187 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
               +        L+ QV+ L+ + +D +R   E+
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  160 bits (406), Expect = 6e-39
 Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)

Query: 254  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
            K  P LQ   +T  ++E+  K  + +    +  + ENE     L++++Q+   L ++ N 
Sbjct: 847  KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 898

Query: 314  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
            LQ QL  E     +L +E E+++  LAAK+++ EE L  +EA     +  E +  G    
Sbjct: 899  LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 949

Query: 374  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
               +K    +   +  + + +                   +L L   T+ ++ + L+ E+
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 994

Query: 434  EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 490
              M        ++R  L+   ++L   +AE +  A    ++K   +  I +LE  LK  +
Sbjct: 995  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054

Query: 491  KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 546
            K   E E            LK  L  +A S  H    +L+ Q+ +LK+    K E   A 
Sbjct: 1055 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
            + +L ++I Q    +++ +  EG + +  + L  E +      ++K     E+E    EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
               L  +   ++   +++    EV    K L E  R HE  + E+RQ             
Sbjct: 1163 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1206

Query: 667  QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 726
                  +H Q    L ++  +  +    L    QTL+KE   +  + ++L +    +   
Sbjct: 1207 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257

Query: 727  MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
                       E  KK  +A + +L  K  D  +   E   ++ KL  E +S++  ++  
Sbjct: 1258 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 787  ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 846
            E   +   K  K++ +L S + + ++ L E  ++      K+  L  E  +L+  +  + 
Sbjct: 1307 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363

Query: 847  VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 896
               +  E    TLN  L+ + ++L D           KK+F+   +   +  ++      
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 897  NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 947
             LE T+N+++ E     + L      +S+L +  RK     AE   I + Y   + + E 
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 948  VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 984
                 E KA             K+EL+   + +K +   +VS            E+ +R 
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 985  FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1026
             +   +E+K QL E   +   +E+                  +++   ++N++ +++   
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1600

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ+ L +    +E   +     +    +L   LKDL  +       +E+ +++  K  ++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 1087 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
            +   Q  L+      +++       E   KSL   +  L+E+L + +R  ++      +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 1140 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1188
             + L +  +    L +          Q++E  E+E G ++A    +R+  ++++    E+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1189 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1237
            +  +S  Q  + A ++LE +           E    SK+K+T + LE +I+ L E++   
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1238 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1293
             R+ +        A  K +  KD+K    LL    E+++ +Q KE+ +K    + +L+R+
Sbjct: 1841 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892

Query: 1294 IQES---AKQIEAKDNKITELLNDVERLKQAL 1322
            ++E+   +++I A   K+   L++     +A+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAM 1924



 Score =  137 bits (344), Expect = 9e-32
 Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)

Query: 476  DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 532
            +E+++  ED L+  ++R  ++E ++K+++                 + +LTEE   L++Q
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 902

Query: 533  LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 591
            L+     Y  A AE  ++R   K+ E+  EE   + E +L EE  R Q+     + ER+K
Sbjct: 903  LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 954

Query: 592  KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 651
              +++ ++E Q +E  A        +K +  K +   ++ +   +++ M+ ++ K   E 
Sbjct: 955  MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 652  RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 711
            + L+  + ++   LA     EE E+ K+            +T+L  K++++  E+E    
Sbjct: 1009 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1048

Query: 712  DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
              +L KE+     +E             +K+  +    D + ++ D+  +  E K+++ K
Sbjct: 1049 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 772  LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 824
               + + L   ++RL+          K+I  L+ +I +L++ L       ++ +K+  + 
Sbjct: 1095 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 825  QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 880
             E++ AL +E    L    + Q +  K  +EV   K  L++       ++ ++++K    
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 881  NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 936
             +E  +  ++ +  K NL+  +  ++ E   LA     +    Q +    +K++    E+
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 937  LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
             +    G+     L+ ++   + E++++   +           E E K     K++    
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1321

Query: 997  SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1056
            S+      + +EE ++    + KL++    L+++       +++  E ++ L R    LN
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 1057 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1116
             QL D  +K  +  +  E L E   +   EI  +    +++    +++E  K  L   ++
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 1117 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1176
            +L  +L + ++     ++   K  QLL  +KN S   A+     EA  +E      SL  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
              EE+    EE+ +    ++   + L   +     ++ + + +K  LETQ+  +  +L  
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1555

Query: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1296
                 EE+ +E+   +  ++  +   + L    E++++ + E+ ++      +LQR++ E
Sbjct: 1556 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1607

Query: 1297 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1356
               ++E +  +        ++L+  L  L     ++    +   + +  LQ Q+K  +++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 1357 LADADRQHQEVIA 1369
            L DA     E+ A
Sbjct: 1668 LEDARASRDEIFA 1680



 Score =  120 bits (300), Expect = 1e-26
 Identities = 184/928 (19%), Positives = 372/928 (40%), Gaps = 89/928 (9%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 295
            LT LK   E+     E+  K     ++ L  ++ ++   +    H+ I DL+ +  +LK 
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1090

Query: 296  RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 348
            +L K ++E +  L +++    Q N  +    +LE      +E L S  AA+   EKQ  +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 349  SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 407
                +EALK   +   +S            +E  +LK+      D +  S         +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1206

Query: 408  SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 452
               + +E               L    QT   EN  L  EL  +      AKQ+    + 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1262

Query: 453  ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 512
            +L  +V E ++   + ER + + ++++ +L++ ++ V   + E+EGK  ++     +L  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 513  HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
             L  T E      R           L EE   L+DQL +     +     +  L  Q+  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 615
            ++  +++F      L E  KR QKE+     + E+K     ++E     L  +L  L + 
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 616  AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 674
             +    + S+L  +  +  + L E +    K   E  + + E    + K     +  EE 
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502

Query: 675  EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 734
             + K  LE+ +  L  ++ +L      + K + ++    + L+ Q   +  +++     L
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562

Query: 735  KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
            + +ED K     +  A+     R L    ++  EK+ ++++ L E ++  +D  +   + 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 791  VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
               +K         E +  +      E  KQL +L+ +  + Q ++    +    +    
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 843  SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 899
                   K+ E   M L + LA   R       + E++ +E          L   KR LE
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 900  NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 956
                Q++ E   L E +  M ++S  +RK      ++   LA  R   ++  +   +++ 
Sbjct: 1743 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 957  QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1012
            Q KEL +    ++  +K K+   ++         A E ++  QL EQ ++ +  ++   K
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1849

Query: 1013 NKQENDKLKKEIFTLQKDLRDKT----VLIEKSHEMERALSRKTDELNKQLKDLSQKYTE 1068
            + ++ DK  KEI    +D R          EK +   + L R+ +E  ++ + ++    +
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909

Query: 1069 VKNVKEKLVEENAKQTSEILAVQNLLQK 1096
            ++   ++  E N     E+ A+++ L++
Sbjct: 1910 LQRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)

Query: 971  KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1030
            K  P++     E + +A E EL+ +  E+ QK   +E E+K+ +Q++ +L +E   LQ+ 
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1031 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1090
            L+ +T L  ++ EM   L+ K  EL + L ++  +  E ++  ++L  E  K   ++L +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            +  L+++    ++++  K +    I+ L++E+  M    + +   ++K  +LLE +    
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1014

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
                  L    A E+E       L+ K E   +++E   +L+ E + ++Q L+KL+ +  
Sbjct: 1015 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1068

Query: 1211 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
             D S +    +DL+ QI+ L  +LA    K EE  +  L     EI+ K+        +E
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1124

Query: 1271 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1316
              I D +E  D       + +++ ++  +++EA   ++ + L+              +V 
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184

Query: 1317 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1365
             LK+AL+  ++         + + +Q ++ L  Q++  ++  A+ D+  Q
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)

Query: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1005
            ++     E++A++ EL   +E  +     +   E+   +    +  L++QL  +T+ Y+ 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 1006 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
            +EE    +   KQE          L++ L +    +E+  +  + L  +  ++ +Q+ DL
Sbjct: 913  AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1063 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1115
             ++  E +  ++KL  E         K   EIL + +   K     + +E     L   +
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1163
               +E+ K++ +   K +  +++L   L+ ++ S   L +            H QI +  
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1081

Query: 1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1217
            + ++  +K  L +KEEE Q     +++L  E+     ALKK+   E        DL   +
Sbjct: 1082 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
            A ++  E Q   L E+L  L  + E+  +    A ++E+ AK E+E+   ++ ++  D++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1193

Query: 1278 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
             R  ++   + E++++    ++E  +Q+E        L  + + L++    L+      G
Sbjct: 1194 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
               +        L+ QV+ L+ + +D +R   E+
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  160 bits (406), Expect = 6e-39
 Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)

Query: 254  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
            K  P LQ   +T  ++E+  K  + +    +  + ENE     L++++Q+   L ++ N 
Sbjct: 847  KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 898

Query: 314  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
            LQ QL  E     +L +E E+++  LAAK+++ EE L  +EA     +  E +  G    
Sbjct: 899  LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 949

Query: 374  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
               +K    +   +  + + +                   +L L   T+ ++ + L+ E+
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 994

Query: 434  EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 490
              M        ++R  L+   ++L   +AE +  A    ++K   +  I +LE  LK  +
Sbjct: 995  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054

Query: 491  KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 546
            K   E E            LK  L  +A S  H    +L+ Q+ +LK+    K E   A 
Sbjct: 1055 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
            + +L ++I Q    +++ +  EG + +  + L  E +      ++K     E+E    EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
               L  +   ++   +++    EV    K L E  R HE  + E+RQ             
Sbjct: 1163 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1206

Query: 667  QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 726
                  +H Q    L ++  +  +    L    QTL+KE   +  + ++L +    +   
Sbjct: 1207 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257

Query: 727  MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
                       E  KK  +A + +L  K  D  +   E   ++ KL  E +S++  ++  
Sbjct: 1258 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 787  ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 846
            E   +   K  K++ +L S + + ++ L E  ++      K+  L  E  +L+  +  + 
Sbjct: 1307 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363

Query: 847  VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 896
               +  E    TLN  L+ + ++L D           KK+F+   +   +  ++      
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 897  NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 947
             LE T+N+++ E     + L      +S+L +  RK     AE   I + Y   + + E 
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 948  VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 984
                 E KA             K+EL+   + +K +   +VS            E+ +R 
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543

Query: 985  FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1026
             +   +E+K QL E   +   +E+                  +++   ++N++ +++   
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1600

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ+ L +    +E   +     +    +L   LKDL  +       +E+ +++  K  ++
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 1087 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
            +   Q  L+      +++       E   KSL   +  L+E+L + +R  ++      +L
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 1140 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1188
             + L +  +    L +          Q++E  E+E G ++A    +R+  ++++    E+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1189 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1237
            +  +S  Q  + A ++LE +           E    SK+K+T + LE +I+ L E++   
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 1238 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1293
             R+ +        A  K +  KD+K    LL    E+++ +Q KE+ +K    + +L+R+
Sbjct: 1841 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892

Query: 1294 IQES---AKQIEAKDNKITELLNDVERLKQAL 1322
            ++E+   +++I A   K+   L++     +A+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAM 1924



 Score =  137 bits (344), Expect = 9e-32
 Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)

Query: 476  DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 532
            +E+++  ED L+  ++R  ++E ++K+++                 + +LTEE   L++Q
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 902

Query: 533  LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 591
            L+     Y  A AE  ++R   K+ E+  EE   + E +L EE  R Q+     + ER+K
Sbjct: 903  LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 954

Query: 592  KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 651
              +++ ++E Q +E  A        +K +  K +   ++ +   +++ M+ ++ K   E 
Sbjct: 955  MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 652  RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 711
            + L+  + ++   LA     EE E+ K+            +T+L  K++++  E+E    
Sbjct: 1009 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1048

Query: 712  DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
              +L KE+     +E             +K+  +    D + ++ D+  +  E K+++ K
Sbjct: 1049 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 772  LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 824
               + + L   ++RL+          K+I  L+ +I +L++ L       ++ +K+  + 
Sbjct: 1095 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 825  QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 880
             E++ AL +E    L    + Q +  K  +EV   K  L++       ++ ++++K    
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 881  NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 936
             +E  +  ++ +  K NL+  +  ++ E   LA     +    Q +    +K++    E+
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 937  LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
             +    G+     L+ ++   + E++++   +           E E K     K++    
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1321

Query: 997  SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1056
            S+      + +EE ++    + KL++    L+++       +++  E ++ L R    LN
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1377

Query: 1057 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1116
             QL D  +K  +  +  E L E   +   EI  +    +++    +++E  K  L   ++
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437

Query: 1117 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1176
            +L  +L + ++     ++   K  QLL  +KN S   A+     EA  +E      SL  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
              EE+    EE+ +    ++   + L   +     ++ + + +K  LETQ+  +  +L  
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1555

Query: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1296
                 EE+ +E+   +  ++  +   + L    E++++ + E+ ++      +LQR++ E
Sbjct: 1556 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1607

Query: 1297 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1356
               ++E +  +        ++L+  L  L     ++    +   + +  LQ Q+K  +++
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667

Query: 1357 LADADRQHQEVIA 1369
            L DA     E+ A
Sbjct: 1668 LEDARASRDEIFA 1680



 Score =  121 bits (303), Expect = 5e-27
 Identities = 189/943 (20%), Positives = 375/943 (39%), Gaps = 102/943 (10%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 295
            LT LK   E+     E+  K     ++ L  ++ ++   +    H+ I DL+ +  +LK 
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1090

Query: 296  RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 348
            +L K ++E +  L +++    Q N  +    +LE      +E L S  AA+   EKQ  +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 349  SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 407
                +EALK   +   +S            +E  +LK+      D +  S         +
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1206

Query: 408  SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 452
               + +E               L    QT   EN  L  EL  +      AKQ+    + 
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1262

Query: 453  ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 512
            +L  +V E ++   + ER + + ++++ +L++ ++ V   + E+EGK  ++     +L  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 513  HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
             L  T E      R           L EE   L+DQL +     +     +  L  Q+  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 615
            ++  +++F      L E  KR QKE+     + E+K     ++E     L  +L  L + 
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 616  AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 674
             +    + S+L  +  +  + L E +    K   E  + + E    + K     +  EE 
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502

Query: 675  EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 734
             + K  LE+ +  L  ++ +L      + K + ++    + L+ Q   +  +++     L
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562

Query: 735  KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
            + +ED K     +  A+     R L    ++  EK+ ++++ L E ++  +D  +   + 
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622

Query: 791  VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
               +K         E +  +      E  KQL +L+ +  + Q ++    +    +    
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 843  SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 899
                   K+ E   M L + LA   R       + E++ +E          L   KR LE
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 900  NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 956
                Q++ E   L E +  M ++S  +RK      ++   LA  R   ++  +   +++ 
Sbjct: 1743 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 957  QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1012
            Q KEL +    ++  +K K+   ++         A E ++  QL EQ ++ +  ++   K
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1849

Query: 1013 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNV 1072
            + ++ DK  KEI      + D+  + E+  E     + +  +L +QL++  ++   +   
Sbjct: 1850 SLKQKDKKLKEILL---QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906

Query: 1073 KEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1113
            + KL  E   A +++E +              +V ALK  L G
Sbjct: 1907 RRKLQRELDEATESNEAMG------------REVNALKSKLRG 1937



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)

Query: 971  KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1030
            K  P++     E + +A E EL+ +  E+ QK   +E E+K+ +Q++ +L +E   LQ+ 
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 902

Query: 1031 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1090
            L+ +T L  ++ EM   L+ K  EL + L ++  +  E ++  ++L  E  K   ++L +
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            +  L+++    ++++  K +    I+ L++E+  M    + +   ++K  +LLE +    
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1014

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
                  L    A E+E       L+ K E   +++E   +L+ E + ++Q L+KL+ +  
Sbjct: 1015 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1068

Query: 1211 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
             D S +    +DL+ QI+ L  +LA    K EE  +  L     EI+ K+        +E
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1124

Query: 1271 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1316
              I D +E  D       + +++ ++  +++EA   ++ + L+              +V 
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184

Query: 1317 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1365
             LK+AL+  ++         + + +Q ++ L  Q++  ++  A+ D+  Q
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)

Query: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1005
            ++     E++A++ EL   +E  +     +   E+   +    +  L++QL  +T+ Y+ 
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 1006 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
            +EE    +   KQE          L++ L +    +E+  +  + L  +  ++ +Q+ DL
Sbjct: 913  AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 1063 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1115
             ++  E +  ++KL  E         K   EIL + +   K     + +E     L   +
Sbjct: 963  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022

Query: 1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1163
               +E+ K++ +   K +  +++L   L+ ++ S   L +            H QI +  
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1081

Query: 1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1217
            + ++  +K  L +KEEE Q     +++L  E+     ALKK+   E        DL   +
Sbjct: 1082 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
            A ++  E Q   L E+L  L  + E+  +    A ++E+ AK E+E+   ++ ++  D++
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1193

Query: 1278 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
             R  ++   + E++++    ++E  +Q+E        L  + + L++    L+      G
Sbjct: 1194 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
               +        L+ QV+ L+ + +D +R   E+
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  160 bits (406), Expect = 6e-39
 Identities = 236/1172 (20%), Positives = 481/1172 (41%), Gaps = 197/1172 (16%)

Query: 254  KKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNG 313
            K  P LQ   +T  ++E+  K  + +    +  + ENE     L++++Q+   L ++ N 
Sbjct: 840  KVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENE-----LKELEQKHSQLTEEKNL 891

Query: 314  LQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSH 373
            LQ QL  E     +L +E E+++  LAAK+++ EE L  +EA     +  E +  G    
Sbjct: 892  LQEQLQAET----ELYAEAEEMRVRLAAKKQELEEILHEMEA-----RLEEEEDRGQQLQ 942

Query: 374  FSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKEL 433
               +K    +   +  + + +                   +L L   T+ ++ + L+ E+
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQ---------------KLQLEKVTAEAKIKKLEDEI 987

Query: 434  EAMRTFCESAKQDRLKLQ---NELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQ 490
              M        ++R  L+   ++L   +AE +  A    ++K   +  I +LE  LK  +
Sbjct: 988  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047

Query: 491  KRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKV----KYEGASAE 546
            K   E E            LK  L  +A S  H    +L+ Q+ +LK+    K E   A 
Sbjct: 1048 KSRQELE-----------KLKRKLEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606
            + +L ++I Q    +++ +  EG + +  + L  E +      ++K     E+E    EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 607  SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLA 666
               L  +   ++   +++    EV    K L E  R HE  + E+RQ             
Sbjct: 1156 EDTLDSTATQQE---LRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------------- 1199

Query: 667  QHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIE 726
                  +H Q    L ++  +  +    L    QTL+KE   +  + ++L +    +   
Sbjct: 1200 ------KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250

Query: 727  MKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
                       E  KK  +A + +L  K  D  +   E   ++ KL  E +S++  ++  
Sbjct: 1251 -----------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 787  ETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 846
            E   +   K  K++ +L S + + ++ L E  ++      K+  L  E  +L+  +  + 
Sbjct: 1300 EGKAI---KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356

Query: 847  VPVKTHEEVKMTLNDTLAKTNRELLDV----------KKKFEDINQEFVKIKDKNEILKR 896
               +  E    TLN  L+ + ++L D           KK+F+   +   +  ++      
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 897  NLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE---ILANY--RKGQEEI 947
             LE T+N+++ E     + L      +S+L +  RK     AE   I + Y   + + E 
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 948  VTLHAEIKA------------QKKELDTIQECIKVKYAPIVS-----------FEECERK 984
                 E KA             K+EL+   + +K +   +VS            E+ +R 
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536

Query: 985  FKATEKELKDQLSEQTQKYSVSEE------------------EVKKNKQENDKLKKEIFT 1026
             +   +E+K QL E   +   +E+                  +++   ++N++ +++   
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ--- 1593

Query: 1027 LQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSE 1086
            LQ+ L +    +E   +     +    +L   LKDL  +       +E+ +++  K  ++
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 1087 ILAVQNLLQKQHVPLEQV-------EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
            +   Q  L+      +++       E   KSL   +  L+E+L + +R  ++      +L
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713

Query: 1140 HQLLENQKNSSVPLAEH--------LQIKEAFEKEVGIIKAS---LREKEEESQNKMEEV 1188
             + L +  +    L +          Q++E  E+E G ++A    +R+  ++++    E+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 1189 SKLQSEVQNTKQALKKLETR-----------EVVDLSKYKATKSDLETQISSLNEKLANL 1237
            +  +S  Q  + A ++LE +           E    SK+K+T + LE +I+ L E++   
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 1238 NRKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQ-KERCDKSLTTITELQRR 1293
             R+ +        A  K +  KD+K    LL    E+++ +Q KE+ +K    + +L+R+
Sbjct: 1834 AREKQ--------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885

Query: 1294 IQES---AKQIEAKDNKITELLNDVERLKQAL 1322
            ++E+   +++I A   K+   L++     +A+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAM 1917



 Score =  137 bits (344), Expect = 9e-32
 Identities = 174/913 (19%), Positives = 396/913 (43%), Gaps = 109/913 (11%)

Query: 476  DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE---LKDQ 532
            +E+++  ED L+  ++R  ++E ++K+++                 + +LTEE   L++Q
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQK---------------HSQLTEEKNLLQEQ 895

Query: 533  LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRD-EGKLIEENKRLQKELSMCEMEREK 591
            L+     Y  A AE  ++R   K+ E+  EE   + E +L EE  R Q+     + ER+K
Sbjct: 896  LQAETELY--AEAEEMRVRLAAKKQEL--EEILHEMEARLEEEEDRGQQ----LQAERKK 947

Query: 592  KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 651
              +++ ++E Q +E  A        +K +  K +   ++ +   +++ M+ ++ K   E 
Sbjct: 948  MAQQMLDLEEQLEEEEAA------RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 652  RQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYL 711
            + L+  + ++   LA     EE E+ K+            +T+L  K++++  E+E    
Sbjct: 1002 KLLEERISDLTTNLA-----EEEEKAKN------------LTKLKNKHESMISELEV--- 1041

Query: 712  DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 771
              +L KE+     +E             +K+  +    D + ++ D+  +  E K+++ K
Sbjct: 1042 --RLKKEEKSRQELEK------------LKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 772  LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQL-------SELKKKCGED 824
               + + L   ++RL+          K+I  L+ +I +L++ L       ++ +K+  + 
Sbjct: 1088 ---KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 825  QEKIHALTSE-NTNLKKMMSNQYVPVKTHEEV---KMTLNDTLAKTNRELLDVKKKFEDI 880
             E++ AL +E    L    + Q +  K  +EV   K  L++       ++ ++++K    
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 881  NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSM----RKVQDSNAEI 936
             +E  +  ++ +  K NL+  +  ++ E   LA     +    Q +    +K++    E+
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 937  LANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQL 996
             +    G+     L+ ++   + E++++   +           E E K     K++    
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLN----------EAEGKAIKLAKDVASLS 1314

Query: 997  SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELN 1056
            S+      + +EE ++    + KL++    L+++       +++  E ++ L R    LN
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDEEMEAKQNLERHISTLN 1370

Query: 1057 KQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIE 1116
             QL D  +K  +  +  E L E   +   EI  +    +++    +++E  K  L   ++
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430

Query: 1117 NLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLRE 1176
            +L  +L + ++     ++   K  QLL  +KN S   A+     EA  +E      SL  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 1177 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
              EE+    EE+ +    ++   + L   +     ++ + + +K  LETQ+  +  +L  
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-- 1548

Query: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQE 1296
                 EE+ +E+   +  ++  +   + L    E++++ + E+ ++      +LQR++ E
Sbjct: 1549 -----EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR---RQLQRQLHE 1600

Query: 1297 SAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1356
               ++E +  +        ++L+  L  L     ++    +   + +  LQ Q+K  +++
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660

Query: 1357 LADADRQHQEVIA 1369
            L DA     E+ A
Sbjct: 1661 LEDARASRDEIFA 1673



 Score =  121 bits (303), Expect = 5e-27
 Identities = 189/943 (20%), Positives = 375/943 (39%), Gaps = 102/943 (10%)

Query: 236  LTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKE 295
            LT LK   E+     E+  K     ++ L  ++ ++   +    H+ I DL+ +  +LK 
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQAQIAELKM 1083

Query: 296  RLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESE----REKLKSLLAAK---EKQHEE 348
            +L K ++E +  L +++    Q N  +    +LE      +E L S  AA+   EKQ  +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 349  SLRTIEALKNRFK-YFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR 407
                +EALK   +   +S            +E  +LK+      D +  S         +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA----LDEETRSHEAQVQEMRQ 1199

Query: 408  SMLRPLE---------------LSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQN 452
               + +E               L    QT   EN  L  EL  +      AKQ+    + 
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVEHKKK 1255

Query: 453  ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKE 512
            +L  +V E ++   + ER + + ++++ +L++ ++ V   + E+EGK  ++     +L  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 513  HL--TSEAASGNHR-----------LTEE---LKDQLKDLKVKYEGASAEVGKLRNQIKQ 556
             L  T E      R           L EE   L+DQL +     +     +  L  Q+  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 557  NEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIP 615
            ++  +++F      L E  KR QKE+     + E+K     ++E     L  +L  L + 
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 616  AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEH 674
             +    + S+L  +  +  + L E +    K   E  + + E    + K     +  EE 
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495

Query: 675  EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL 734
             + K  LE+ +  L  ++ +L      + K + ++    + L+ Q   +  +++     L
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555

Query: 735  KVSEDMKK----SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 790
            + +ED K     +  A+     R L    ++  EK+ ++++ L E ++  +D  +   + 
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615

Query: 791  VPPEKH--------EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 842
               +K         E +  +      E  KQL +L+ +  + Q ++    +    +    
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 843  SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEIL---KRNLE 899
                   K+ E   M L + LA   R       + E++ +E          L   KR LE
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 900  NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI---LANYRKGQEEIVTLHAEIKA 956
                Q++ E   L E +  M ++S  +RK      ++   LA  R   ++  +   +++ 
Sbjct: 1736 ARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 957  QKKELDT----IQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKK 1012
            Q KEL +    ++  +K K+   ++         A E ++  QL EQ ++ +  ++   K
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIA---------ALEAKIA-QLEEQVEQEAREKQAATK 1842

Query: 1013 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNV 1072
            + ++ DK  KEI      + D+  + E+  E     + +  +L +QL++  ++   +   
Sbjct: 1843 SLKQKDKKLKEILL---QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899

Query: 1073 KEKLVEE--NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNG 1113
            + KL  E   A +++E +              +V ALK  L G
Sbjct: 1900 RRKLQRELDEATESNEAMG------------REVNALKSKLRG 1930



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 92/410 (22%), Positives = 195/410 (47%), Gaps = 37/410 (9%)

Query: 971  KYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKD 1030
            K  P++     E + +A E EL+ +  E+ QK   +E E+K+ +Q++ +L +E   LQ+ 
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQ-KTKERQQK---AENELKELEQKHSQLTEEKNLLQEQ 895

Query: 1031 LRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV 1090
            L+ +T L  ++ EM   L+ K  EL + L ++  +  E ++  ++L  E  K   ++L +
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1091 QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSS 1150
            +  L+++    ++++  K +    I+ L++E+  M    + +   ++K  +LLE +    
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM----DDQNNKLSKERKLLEER---- 1007

Query: 1151 VPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV 1210
                  L    A E+E       L+ K E   +++E   +L+ E + ++Q L+KL+ +  
Sbjct: 1008 ---ISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKE-EKSRQELEKLKRKLE 1061

Query: 1211 VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1270
             D S +    +DL+ QI+ L  +LA    K EE  +  L     EI+ K+        +E
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLA----KKEEELQAALARLDDEIAQKNNALKKIRELE 1117

Query: 1271 QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN--------------DVE 1316
              I D +E  D       + +++ ++  +++EA   ++ + L+              +V 
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177

Query: 1317 RLKQALNGLSQLTYTSGNPTK-RQSQLIDTLQHQVKSLEQQLADADRQHQ 1365
             LK+AL+  ++         + + +Q ++ L  Q++  ++  A+ D+  Q
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 91/454 (20%), Positives = 198/454 (43%), Gaps = 53/454 (11%)

Query: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSV 1005
            ++     E++A++ EL   +E  +     +   E+   +    +  L++QL  +T+ Y+ 
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 1006 SEE---EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
            +EE    +   KQE          L++ L +    +E+  +  + L  +  ++ +Q+ DL
Sbjct: 906  AEEMRVRLAAKKQE----------LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 1063 SQKYTEVKNVKEKLVEENA-------KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1115
             ++  E +  ++KL  E         K   EIL + +   K     + +E     L   +
Sbjct: 956  EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015

Query: 1116 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE------------HLQIKEAF 1163
               +E+ K++ +   K +  +++L   L+ ++ S   L +            H QI +  
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-L 1074

Query: 1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYK 1217
            + ++  +K  L +KEEE Q     +++L  E+     ALKK+   E        DL   +
Sbjct: 1075 QAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1218 ATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQK 1277
            A ++  E Q   L E+L  L  + E+  +    A ++E+ AK E+E+   ++ ++  D++
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEV---TVLKKALDEE 1186

Query: 1278 ERCDKSLTTITELQRR----IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSG 1333
             R  ++   + E++++    ++E  +Q+E        L  + + L++    L+      G
Sbjct: 1187 TRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244

Query: 1334 NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1367
               +        L+ QV+ L+ + +D +R   E+
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  159 bits (403), Expect = 1e-38
 Identities = 212/1033 (20%), Positives = 435/1033 (42%), Gaps = 148/1033 (14%)

Query: 429  LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 488
            LKK+++ ++     A++++   +N++ +   E  AL           DE + +L    K 
Sbjct: 999  LKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAAL-----------DESVARLTKEKKA 1047

Query: 489  VQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKD------QLKDLKVKYEG 542
            +Q+   ++ G         L  +E   S       RL ++++D      Q K L++  E 
Sbjct: 1048 LQEAHQQALGD--------LQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER 1099

Query: 543  ASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG-------RK 595
            A     KL   +K  +  V +  +D+ +L E+ K+   ELS   +  E +        +K
Sbjct: 1100 AKR---KLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKK 1156

Query: 596  VTEMEGQAKELSAKLALSIPAE-KFENMKSSLSNEVNEKAKKLVEM------EREH-EKS 647
            + E++ +A+EL  +L     A  + E  ++  + E+ E +++L E       +RE   K 
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR 1216

Query: 648  LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQK----SGELGKKITELTLKNQTLQ 703
             +E+ +L+RELE    +         HE   + L +K    + ELG+++  L    Q L+
Sbjct: 1217 EAELGRLRRELEEAALR---------HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLE 1267

Query: 704  KEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ--- 760
            KE  ++ ++   L      LT    +     +  ED        +++L R+L D +    
Sbjct: 1268 KEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRG 1327

Query: 761  KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 820
            +   +  E+ +LL E + L   +SR + +                ++ EL++QL E  K 
Sbjct: 1328 RLQTESGELSRLLEEKECLISQLSRGKALAA-------------QSLEELRRQLEEESKA 1374

Query: 821  CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE-D 879
                   + AL  +   L++    +        E +  L   L+K N E+   + K+E D
Sbjct: 1375 KSALAHAVQALRHDCDLLREQHEEE-------AEAQAELQRLLSKANAEVAQWRSKYEAD 1427

Query: 880  INQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILAN 939
              Q   ++++  + L   L+  +  ++A         AK SSL ++  ++Q  + ++   
Sbjct: 1428 AIQRTEELEEAKKKLALRLQEAEEGVEAA-------NAKCSSLEKAKLRLQTESEDVTLE 1480

Query: 940  YRKGQEEIVTL--------------HAEIKAQKKELDTIQ--------ECIKVKYAPIVS 977
              +       L                + +  ++EL+  Q        E  ++++    +
Sbjct: 1481 LERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEA 1540

Query: 978  FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1037
             E  E   K   K L++++S+ T + S+S + +++ ++    L+ E   +Q  L +    
Sbjct: 1541 LEALET-LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGA 1599

Query: 1038 IE----KSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1093
            +E    K+  ++  LS+   E++++L +  ++   ++   ++ VE          ++Q  
Sbjct: 1600 LELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVE----------SLQAS 1649

Query: 1094 LQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQ--LLENQ--KNS 1149
            L  +     +   LKK + G + +L+ +L    R    E Q  T+L Q  L E Q  ++ 
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATR-QATEAQAATRLMQAQLKEEQAGRDE 1708

Query: 1150 SVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETR 1208
               LA  L  + +A E+   ++ A L E     +         + E+    + L  L ++
Sbjct: 1709 EQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768

Query: 1209 EVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL-------HAKKKEISAKDE 1261
                L++ K  ++DL  Q+S   E+ A   R+ EE  ++ +          KKE      
Sbjct: 1769 NTGLLNQKKKLEADL-AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAH 1827

Query: 1262 KELLHFSIEQEIKDQKERCDKSLTT--------ITELQRRIQESAKQIEAKDNKITELLN 1313
             E +  ++EQ +++ + R +++           + +L+ +++E   +++A+  K  E L 
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887

Query: 1314 DVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR- 1372
             V + ++ +  L+           R   L+D LQ +VKS ++Q  +A++Q    +A YR 
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRK 1947

Query: 1373 -THLLSAAQGHMD 1384
              H L  A+   D
Sbjct: 1948 AQHELDDAEERAD 1960



 Score =  135 bits (340), Expect = 3e-31
 Identities = 220/1068 (20%), Positives = 455/1068 (42%), Gaps = 115/1068 (10%)

Query: 281  QNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLA 340
            + ++D E  N DL  R RK++ E   L   ++ L+L L +        E++ + L   +A
Sbjct: 973  ERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMA 1032

Query: 341  AKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGI 400
            A     +ES+  +   K   +      LG                     A+    S   
Sbjct: 1033 AL----DESVARLTKEKKALQEAHQQALGD------------------LQAEEDRVSALT 1070

Query: 401  PAHMQSRSMLRPLELSLPSQTSY-SENEILKKELEA-MRTFCES---AKQDRLKLQNELA 455
             A ++    +  LE SL  +     + E  K++LE  ++   ES   A QD+ +L+ +L 
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLK 1130

Query: 456  HKVAECKALALECERVKEDSDEQI--KQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH 513
             K +E   L+L  E      DEQ+   Q++  +K++Q R  E E ++ + +    A  E 
Sbjct: 1131 KKDSELSQLSLRVE------DEQLLGAQMQKKIKELQARAEELEEEL-EAERAARARVEK 1183

Query: 514  LTSEAASGNHRLTEELKDQLKDLKVKYEGA---SAEVGKLRNQIKQ----NEMIVEEFKR 566
              +EAA     L+E L++       + EG     AE+G+LR ++++    +E  V   +R
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243

Query: 567  DE----GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFEN 621
             +     +L E+   LQ+     E E+ +   +V ++    + L+ AK +       +E+
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303

Query: 622  MKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL 681
              S    +V E  ++L +   +  +  +E  +L R LE  +  ++Q        + K+  
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQ------LSRGKALA 1357

Query: 682  EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPL--KVSED 739
             Q   EL +++ E +     L   ++ +  D  LL+EQ H    E +     L  K + +
Sbjct: 1358 AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQ-HEEEAEAQAELQRLLSKANAE 1416

Query: 740  M-----KKSHDAI-----IDDLNRKLLDVTQKYTE-------KKLEMEKLLLENDSLSKD 782
            +     K   DAI     +++  +KL    Q+  E       K   +EK  L   + S+D
Sbjct: 1417 VAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESED 1476

Query: 783  VS-RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKM 841
            V+  LE         +K+   L+  + E ++Q  E++++    Q +   L +E   L+  
Sbjct: 1477 VTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHG 1536

Query: 842  MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENT 901
                   ++T +     L + ++    ++    K  +++ +    ++ +   ++  LE  
Sbjct: 1537 HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596

Query: 902  QNQIKAEYISLAEHEAKMSSLSQSM-RKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 960
            +  ++ E       + ++S +   + RK+ + + E     R  Q  + +L A + A+ + 
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRA 1656

Query: 961  LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020
             +   E +++K           +K +    +L+ QL   T++ + ++   +  + +   L
Sbjct: 1657 RN---EALRLK-----------KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQ---L 1699

Query: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080
            K+E    Q    ++  L  + HE  +AL R+   L  +L++L +   E      +L E+ 
Sbjct: 1700 KEE----QAGRDEEQRLAAELHEQAQALERRASLLAAELEEL-RAALEQGERSRRLAEQE 1754

Query: 1081 AKQTSEILAVQNLLQKQHVPL----EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTV 1136
              + +E L   NLL  Q+  L    +++EA    L+G +E   +E +  +   EK ++ +
Sbjct: 1755 LLEATERL---NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAE---EKAKKAI 1808

Query: 1137 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEV 1195
            T    + E  K      A   ++K+  E+ V  ++A L E E+ + +   ++V KL+++V
Sbjct: 1809 TDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKV 1868

Query: 1196 QNTKQAL---KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1252
            +  +  L   +K     +  + K++    +L  Q     + LA +    +++  +V   K
Sbjct: 1869 RELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYK 1928

Query: 1253 KKEISAKDEKE---LLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1297
            ++   A+ +       +   + E+ D +ER D + T   +L+ R +++
Sbjct: 1929 RQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDA 1976



 Score =  125 bits (314), Expect = 3e-28
 Identities = 221/1023 (21%), Positives = 411/1023 (40%), Gaps = 198/1023 (19%)

Query: 410  LRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECE 469
            ++PL   L S  +  E   L+ EL  +R    +A+  R +L+        E   LAL+ +
Sbjct: 885  MKPL---LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQ 941

Query: 470  RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEE- 528
              +++    +   E+    + K   + EGKVK++    L  +E + ++ A+   +L +E 
Sbjct: 942  AEQDN----LADAEERCHLLIKSKVQLEGKVKELSER-LEDEEEVNADLAARRRKLEDEC 996

Query: 529  --LKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCE 586
              LK  + DLK+    A  E     N++K     +        +L +E K LQ      E
Sbjct: 997  TELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ------E 1050

Query: 587  MEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVN-----EKAKKLVEME 641
              ++  G    E +  +    AKL L    ++ E+++ SL  E       E+AK+ +E +
Sbjct: 1051 AHQQALGDLQAEEDRVSALTKAKLRLE---QQVEDLECSLEQEKKLRMDTERAKRKLEGD 1107

Query: 642  RE-HEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS---GELGKKITELTL 697
             +  ++S+++  Q K++LE    K     K  E  Q+  R+E +     ++ KKI EL  
Sbjct: 1108 LKLTQESVADAAQDKQQLEEKLKK-----KDSELSQLSLRVEDEQLLGAQMQKKIKELQA 1162

Query: 698  KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS-------------------- 737
            + + L++E+E        +++Q      E++     L+ +                    
Sbjct: 1163 RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGR 1222

Query: 738  -----EDMKKSHDAIIDDLNRKLLDVTQKYTEK---------KLEMEK--LLLENDSLSK 781
                 E+    H+A +  L RK  +   +  E+         KLE EK  L +E D L+ 
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1282

Query: 782  DVSRLETVFVPPEK----HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTN 837
            +V  L       EK    +E ++   K  + EL++QL++   + G        L +E+  
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGR-------LQTESGE 1335

Query: 838  LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRN 897
            L +++  +   +      K     +L +  R+L +  K    +      ++   ++L+  
Sbjct: 1336 LSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLRE- 1394

Query: 898  LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ 957
                            +HE +  + ++  R +  +NAE+ A +R                
Sbjct: 1395 ----------------QHEEEAEAQAELQRLLSKANAEV-AQWRS--------------- 1422

Query: 958  KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1017
            K E D IQ             EE E        E K +L+ + Q+   +EE V+    + 
Sbjct: 1423 KYEADAIQRT-----------EELE--------EAKKKLALRLQE---AEEGVEAANAKC 1460

Query: 1018 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLV 1077
              L+K    LQ +  D T+ +E++     AL +K   L + L++  ++  E++   E   
Sbjct: 1461 SSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQ 1520

Query: 1078 EENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1137
             E+    +E      L + +H   E +EAL        E LK E K++Q           
Sbjct: 1521 RESRGLGTE------LFRLRHGHEEALEAL--------ETLKRENKNLQE---------- 1556

Query: 1138 KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQN 1197
            ++  L +    S   + E  + K+A E E   I+A+L E E               E++ 
Sbjct: 1557 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL------------ELEE 1604

Query: 1198 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEIS 1257
            TK    +LE  +V         K++++ +++  +E+ ANL R ++   E +  +   E  
Sbjct: 1605 TKTLRIQLELSQV---------KAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655

Query: 1258 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQ---RRIQESAKQIEAKDNKITELLND 1314
            A++E   L   +E ++ D + +   +    TE Q   R +Q   K+ +A  ++   L  +
Sbjct: 1656 ARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715

Query: 1315 VERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVI-AIYRT 1373
            +    QAL              +R S L   L+    +LEQ         QE++ A  R 
Sbjct: 1716 LHEQAQALE-------------RRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1762

Query: 1374 HLL 1376
            +LL
Sbjct: 1763 NLL 1765



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 87/441 (19%), Positives = 186/441 (42%), Gaps = 30/441 (6%)

Query: 239  LKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNV--KSHQREHQNIQDLEIENEDLKER 296
            L+   E   +  E  K+     Q  ++ + D+V++  KS Q   +  + LE E  +++  
Sbjct: 1533 LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAA 1592

Query: 297  LRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEAL 356
            L + +    +   K   +QL+L++     D   +E+++     A   + H+ ++ +++A 
Sbjct: 1593 LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDE---ECANLRRNHQRAVESLQAS 1649

Query: 357  KNRFKYFESDHLGSGSHFSNRKEDMLLKQGQ--MYMADSQCTSPGIPAHMQSRSMLR--- 411
             +      ++ L           D+ L+ G       ++Q  +  + A ++     R   
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709

Query: 412  ---PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALEC 468
                 EL   +Q       +L  ELE +R   E  ++ R   + EL         L  + 
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769

Query: 469  ERV---KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNH-- 523
              +   K+  +  + QL   +++  +   E+E K K+  T    + E L  E  +  H  
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1829

Query: 524  RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELS 583
            R+ + L+  +++L+ + E   AE   LR   KQ + +  + +  E +L  E K+  + L 
Sbjct: 1830 RMKKTLEQTVRELQARLE--EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887

Query: 584  MCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMERE 643
                   K  R+V E+  QA+E    LA      + +++   L ++V    ++  E E++
Sbjct: 1888 GV----RKHERRVKELAYQAEEDRKNLA------RMQDLVDKLQSKVKSYKRQFEEAEQQ 1937

Query: 644  HEKSLSEIRQLKRELENVKAK 664
               +L++ R+ + EL++ + +
Sbjct: 1938 ANTNLAKYRKAQHELDDAEER 1958


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  157 bits (398), Expect = 5e-38
 Identities = 218/999 (21%), Positives = 422/999 (42%), Gaps = 122/999 (12%)

Query: 474  DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEH-----LTSEAASGNHRLTEE 528
            ++++++  +++    +++ + +SE + K+++   ++L +      L  +A   N    EE
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905

Query: 529  LKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK-----ELS 583
              DQL   K++ E   A+V ++  +++  E +  E    + KL +E   L+K     EL+
Sbjct: 906  RCDQLIKNKIQLE---AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962

Query: 584  MCEMEREK-----KGRKVTEMEGQAKELSAKLALSIPA--EKFENMKSSLSNE---VNEK 633
            + ++E+EK     K + +TE      E+ AKL     A  E  +     L  E   VN  
Sbjct: 963  LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSL 1022

Query: 634  AKKLVEMEREH---EKSLSEIRQLKRELENVKAKLAQHVKPEEH-----EQVKSRLEQKS 685
            +K  V++E++    E SL + ++++ +LE  K KL   +K  +      E  K +LE+K 
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK- 1081

Query: 686  GELGKKITELTLKNQTLQKE-IEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSH 744
              L KK  ++  +N  ++ E +  + L  KL + QA    +E +     L+     +   
Sbjct: 1082 --LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE-----LEAERTARAKV 1134

Query: 745  DAIIDDLNRKLLDVTQKYTE------------KKLEMEKLLLENDSLSKDVSRLETVFVP 792
            + +  DL+R+L +++++  E            KK E E   +  D     +    T    
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194

Query: 793  PEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTH 852
             +KH   +  L   I  L++   +L+K+  E + ++  +TS    + K  +N        
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL------- 1247

Query: 853  EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISL 912
            E+V  TL D   +   +L + ++   D   +  K++ +N  L R LE  +  I       
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK 1307

Query: 913  AEHEAKMSSLSQSMR---KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 969
              +  +M  L + +    K +++ A  L + R   + +   + E    K EL  +     
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367

Query: 970  VKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQK 1029
             + A   +  E +   + TE EL++   +  Q+   +EE V+    +   L+K    LQ 
Sbjct: 1368 SEVAQWRTKYETDA-IQRTE-ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425

Query: 1030 DLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1089
            ++ D  V +E+S+    AL +K    +K L +  QKY E ++  E   +E    ++E+  
Sbjct: 1426 EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1485

Query: 1090 VQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL-KSMQRCYE----KEQQTVTKLHQLLE 1144
            ++N  ++    LE  +   K+L   I +L E+L +  +  +E    ++Q  V KL   L+
Sbjct: 1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE--LQ 1543

Query: 1145 NQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1203
            +    +    EH + K    + E   IKA +  K  E   +ME+  +    V ++ Q   
Sbjct: 1544 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSL 1603

Query: 1204 KLETR---EVVDL-SKYKATKSDLETQISSLNEKLANLNRKYE----------------- 1242
              ETR   EV+ +  K +   +++E Q+S  N   A   ++ +                 
Sbjct: 1604 DAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1663

Query: 1243 -------------EVCEEVLHAKKKEISA-KDEKELLHFSIEQEIKDQKERCD------- 1281
                         E    +L A+ +E+ A  ++ E      EQE+ +  ER         
Sbjct: 1664 RANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1723

Query: 1282 -------KSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGN 1334
                   K  + +T+LQ  ++E+ ++    + K  + + D   + + L      +     
Sbjct: 1724 SLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1783

Query: 1335 PTKRQSQLIDTLQHQVKSLEQ-QLADADRQHQEVIAIYR 1372
              K   Q I  LQH++   EQ  L    +Q Q++ A  R
Sbjct: 1784 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1822



 Score =  149 bits (377), Expect = 1e-35
 Identities = 227/1088 (20%), Positives = 470/1088 (43%), Gaps = 167/1088 (15%)

Query: 231  DNLDILTLLKTASEN---TNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQN-IQDL 286
            D+L+ LTL K   E     NK + L ++   L +      +++   K+ Q  HQ  + DL
Sbjct: 957  DDLE-LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK---KALQEAHQQALDDL 1012

Query: 287  EIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQH 346
            ++E    ++++  + + +  L  +V+ L+  L +E  V  DLE  + KL+  L    K  
Sbjct: 1013 QVE----EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL----KLT 1064

Query: 347  EESLRTIE----ALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPA 402
            +ES+  +E     L+ + K  E D     S   +  E +L  Q Q  + ++Q     +  
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIED--EQVLALQLQKKLKENQARIEELEE 1122

Query: 403  HMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRL------KLQNELAH 456
             +++    R     L S  S    EI ++  EA        + ++       K++ +L  
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182

Query: 457  KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTS 516
               + +A A    +   DS  ++ +  D L+ V++++ + + + K       +  E +  
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII- 1241

Query: 517  EAASGNHRLTEELKDQLKDLKVKYEGAS--------------AEVGKLRNQIKQNEMIVE 562
            +A +   +++  L+DQ  + +VK E A                E G+L  Q+++ E ++ 
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS 1301

Query: 563  EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 622
            +  R +    ++ + L+++L               E EG+AK   A  AL       + +
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQL---------------EEEGKAKNALAH-ALQSARHDCDLL 1345

Query: 623  KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 682
            +     E   KA    E++R   K+ SE+ Q + + E    +     + EE E+ K +L 
Sbjct: 1346 REQYEEETEAKA----ELQRVLSKANSEVAQWRTKYETDAIQ-----RTEELEEAKKKLA 1396

Query: 683  QKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK 742
            Q+  +  + +  +  K  +L+K   +       L+ +  +L ++++         +  ++
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHR-------LQNEIEDLMVDVERSNAAAAALDKKQR 1449

Query: 743  SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIA 802
            + D I       L +  QKY E + E+E    E  SLS ++ +L+  +   E+  + +  
Sbjct: 1450 NFDKI-------LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY---EESLEHLET 1499

Query: 803  LKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDT 862
             K     L++++S+L ++ GE  + +H L      L              E  K+ L   
Sbjct: 1500 FKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL--------------EVEKLELQSA 1545

Query: 863  LAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYI-SLAEHEAKMSS 921
            L +    L                  ++ +IL+  LE   NQIKAE    LAE + +M  
Sbjct: 1546 LEEAEASLEH----------------EEGKILRAQLEF--NQIKAEIERKLAEKDEEMEQ 1587

Query: 922  LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC 981
              ++ ++V DS    L    + + E++ +  +++    E++     I++ +A  ++  E 
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME-----IQLSHANRMA-AEA 1641

Query: 982  ERKFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD----- 1033
            +++ K+ +  LKD   QL +  +     +E +   ++ N+ L+ E+  L+  +       
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701

Query: 1034 ---KTVLIEKSHEMERALSRKTDELNKQLK---DLSQKYTEVKNVKEKL--VEENAKQT- 1084
               +  LIE S  ++   S+ T  +N++ K   DL+Q  +EV+   ++    EE AK+  
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761

Query: 1085 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL--------KSMQRCYEKEQQTV 1136
            ++   +   L+K+      +E +KK++  TI++L+  L        K  ++  +K +  V
Sbjct: 1762 TDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1821

Query: 1137 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKM---EEVSKLQS 1193
             +L   LE ++  +    + ++  E   KE+        + EE+ +N +   + V KLQ 
Sbjct: 1822 RELEGELEAEQKRNAESVKGMRKSERRIKELTY------QTEEDKKNLLRLQDLVDKLQL 1875

Query: 1194 EVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1253
            +V+  K+  ++ E +   +LSK++  + +L+      +   + +N+         L AK 
Sbjct: 1876 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK---------LRAKS 1926

Query: 1254 KEISAKDE 1261
            ++I AK +
Sbjct: 1927 RDIGAKQK 1934


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,255,330
Number of Sequences: 37866
Number of extensions: 2075090
Number of successful extensions: 36965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 871
Number of HSP's successfully gapped in prelim test: 1481
Number of HSP's that attempted gapping in prelim test: 10566
Number of HSP's gapped (non-prelim): 12063
length of query: 1403
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1288
effective length of database: 13,892,928
effective search space: 17894091264
effective search space used: 17894091264
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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