Guide to the Human Genome
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Search of human proteins with 56549694

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56549694 enabled homolog isoform a [Homo sapiens]
         (591 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56549694 enabled homolog isoform a [Homo sapiens]                 1181   0.0  
gi|39930375 enabled homolog isoform b [Homo sapiens]                 1126   0.0  
gi|7706687 Enah/Vasp-like [Homo sapiens]                              210   3e-54
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]       170   4e-42
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...   104   3e-22
gi|33356148 formin-like 1 [Homo sapiens]                               99   1e-20
gi|148746195 trichohyalin [Homo sapiens]                               98   2e-20
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]         98   2e-20
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                94   3e-19
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                94   3e-19
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    94   4e-19
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    94   4e-19
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     94   5e-19
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     94   5e-19
gi|18426913 drebrin 1 isoform b [Homo sapiens]                         93   6e-19
gi|18426915 drebrin 1 isoform a [Homo sapiens]                         93   6e-19
gi|52485606 formin-like 2 [Homo sapiens]                               92   1e-18
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      92   1e-18
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       92   1e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    90   7e-18
gi|21071077 dishevelled-associated activator of morphogenesis 1 ...    90   7e-18
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            89   9e-18
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      89   1e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            88   2e-17
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                87   3e-17
gi|160707881 formin 2 [Homo sapiens]                                   87   3e-17
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     87   6e-17
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    86   7e-17
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    86   7e-17
gi|210032580 SET domain containing 1B [Homo sapiens]                   86   7e-17

>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 1181 bits (3056), Expect = 0.0
 Identities = 591/591 (100%), Positives = 591/591 (100%)

Query: 1   MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
           MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI
Sbjct: 1   MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60

Query: 61  NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
           NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL
Sbjct: 61  NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120

Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
           PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER
Sbjct: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180

Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
           LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER
Sbjct: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240

Query: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
           ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET
Sbjct: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300

Query: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
           PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV
Sbjct: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360

Query: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
           PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG
Sbjct: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420

Query: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
           VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV
Sbjct: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480

Query: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540
           TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL
Sbjct: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540

Query: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591
           SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA
Sbjct: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 1126 bits (2912), Expect = 0.0
 Identities = 570/591 (96%), Positives = 570/591 (96%), Gaps = 21/591 (3%)

Query: 1   MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
           MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI
Sbjct: 1   MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60

Query: 61  NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
           NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL
Sbjct: 61  NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120

Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
           PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER
Sbjct: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180

Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
           LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER
Sbjct: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240

Query: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
           ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET
Sbjct: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300

Query: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
           PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV
Sbjct: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360

Query: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
           PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG
Sbjct: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420

Query: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
           VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV
Sbjct: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480

Query: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540
           TSKASSTSTPEPTRKPWERTNTMNGSKSPVIS                     RPKSTPL
Sbjct: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVIS---------------------RPKSTPL 519

Query: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591
           SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA
Sbjct: 520 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 570


>gi|7706687 Enah/Vasp-like [Homo sapiens]
          Length = 418

 Score =  210 bits (535), Expect = 3e-54
 Identities = 108/161 (67%), Positives = 128/161 (79%), Gaps = 11/161 (6%)

Query: 2   SEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
           SEQSICQARA+VMVYDD +KKWVP   G  GFSR++IYH+T +NTFRVVG K+QD QVVI
Sbjct: 4   SEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63

Query: 61  NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
           N +I KGLKYNQAT TFHQWRDARQVYGLNF SKE+A  F++AM+ AL ++NSQE GP+ 
Sbjct: 64  NYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSS 123

Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQE---QQRQKELER 158
            R       QVQNGPS +E++IQRRQ+ E   QQRQ+ LER
Sbjct: 124 QR-------QVQNGPSPDEMDIQRRQVMEQHQQQRQESLER 157



 Score =  179 bits (454), Expect = 6e-45
 Identities = 122/285 (42%), Positives = 162/285 (56%), Gaps = 42/285 (14%)

Query: 317 PPLPPG-PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP---PPPAPPL 372
           P LPPG P+ A+ A           P+  +GPPPPPPPP     VPPPP    PPP PPL
Sbjct: 164 PILPPGHPSSAASA-----------PVSCSGPPPPPPPP-----VPPPPTGATPPPPPPL 207

Query: 373 PASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGR 432
           PA G      S D   ++GLAAAIAGAKLR+V R ED    SGG++    S +SK+D  R
Sbjct: 208 PAGG--AQGSSHDESSMSGLAAAIAGAKLRRVQRPEDA---SGGSS---PSGTSKSDANR 259

Query: 433 GNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASST----- 487
            +     GG GLMEEM+ LLA+RR+ A + S    E+KED+ +  +P TS +  T     
Sbjct: 260 ASS--GGGGGGLMEEMNKLLAKRRKAASQ-SDKPAEKKEDESQMEDPSTSPSPGTRAASQ 316

Query: 488 --STPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSA 545
             ++ E  RKPWER+N++    S ++SR  S  K+             +P S      S 
Sbjct: 317 PPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKS----PEAKSPLQSQPHSRMKPAGSV 372

Query: 546 NGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNT 590
           N +  +  D DR+KQ+IL+E+ +EL K+KEE+IDAIRQELS  +T
Sbjct: 373 NDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGIST 417



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 16/118 (13%)

Query: 210 LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAA 269
           +  QE     +R  +      E +   R   E+ +++RQE LER           +SA  
Sbjct: 114 MNSQEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERR----------TSATG 163

Query: 270 PASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS 327
           P      L      S+AS P   +   P   P       G    PPPPPLP G AQ S
Sbjct: 164 PI-----LPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATP-PPPPPLPAGGAQGS 215


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score =  170 bits (430), Expect = 4e-42
 Identities = 94/149 (63%), Positives = 108/149 (72%), Gaps = 8/149 (5%)

Query: 1   MSEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQ-DHQV 58
           MSE  IC +RA VM+YDD NK+W+PAG G   FSRV IYH+   N+FRVVGRK+Q D QV
Sbjct: 1   MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQV 60

Query: 59  VINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGP 118
           VINCAI +G+KYNQAT  FHQWRDARQV+GLNFGSKEDA  FA+ M  ALE L  +  GP
Sbjct: 61  VINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEAL--EGGGP 118

Query: 119 TLPRQNSQLPA-QVQNGPSQEELEIQRRQ 146
             P     LP   V NGPS EE+E Q+RQ
Sbjct: 119 PPP---PALPTWSVPNGPSPEEVEQQKRQ 144



 Score =  149 bits (375), Expect = 9e-36
 Identities = 112/308 (36%), Positives = 147/308 (47%), Gaps = 82/308 (26%)

Query: 313 PPPPPPLP-------PGPAQASVALPPPPGPPP-----------PPPLPSTGPPPPPPPP 354
           PPPPP LP       P P +        PGP             PP  P+ GPPPPP PP
Sbjct: 118 PPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPP 177

Query: 355 PLPNQVPPP--PP-------------PPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGA 399
           P P   PPP  PP             PPPAPPLPA+               GLAAAIAGA
Sbjct: 178 PPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAA----QGPGGGGAGAPGLAAAIAGA 233

Query: 400 KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIA 459
           KLRKVS+ E+    SGG        + K ++GR       GG GLMEEM+A+LARRR+  
Sbjct: 234 KLRKVSKQEEA---SGG------PTAPKAESGRS------GGGGLMEEMNAMLARRRKAT 278

Query: 460 EKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRK 519
           + G   E   K++     EP   +A   +  E  R+PWE+ +T              PR 
Sbjct: 279 QVG---EKTPKDESANQEEP---EARVPAQSESVRRPWEKNST------------TLPRM 320

Query: 520 NQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELID 579
                  +S  S+   ++ P +  S     ++  D  R+KQ++L+E++KEL K+KEE+I+
Sbjct: 321 -------KSSSSVTTSETQPCTPSS-----SDYSDLQRVKQELLEEVKKELQKVKEEIIE 368

Query: 580 AIRQELSK 587
           A  QEL K
Sbjct: 369 AFVQELRK 376


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score =  104 bits (259), Expect = 3e-22
 Identities = 72/194 (37%), Positives = 93/194 (47%), Gaps = 28/194 (14%)

Query: 312 APPPPP-------PLPPGPAQASVALPPPPG----PPPPPPLPSTGPPPPPPPPPLPNQV 360
           APPPPP       P PP P++ SVA+PPPP     PPPPP LPS+ P  PPPPPP    V
Sbjct: 309 APPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGV 368

Query: 361 ----PPPPPPPPAPPLPASGFFLASMSEDNRPLT-GLAAAI-----AGAKLRKVSRMEDT 410
               PPPPPPPP PP P     L S  +   P T G  AA+      GA+L+KV +    
Sbjct: 369 GPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRP 428

Query: 411 SFPSGGNAI------GVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGST 464
              SG +A+      G+    S  D      P P   SG++  +  ++ +R +       
Sbjct: 429 VSCSGRDALLDQIRQGI-QLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDE 487

Query: 465 IETEQKEDKGEDSE 478
            E E  E+  ED +
Sbjct: 488 DEDEDDEEDFEDDD 501


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 82/235 (34%), Positives = 97/235 (41%), Gaps = 63/235 (26%)

Query: 189 EQLERERQERERQERLERQ-----ERLERQERLERQERLDRERQERQERERLERLERERQ 243
           E  E +    E  E L+ Q     ERL   E     +  + E+Q  Q R+ LE L     
Sbjct: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFS 448

Query: 244 E----------------------RERQEQLEREQLEWERERRI--------SSAAAPASV 273
           E                      R    +L+ E+LE +   RI        S    P +V
Sbjct: 449 ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAV 508

Query: 274 ETPLNSVLGDSSASEPGLQAASQ-----PAETPSQQGIVLGPLAPPPPPPLP--PGPAQA 326
            TP     GD  A  PG+   S      PA  P+         APPPPPPLP  P P +A
Sbjct: 509 ATPSG---GD--APTPGVPTGSPSPDLAPAAEPAPGA------APPPPPPLPGLPSPQEA 557

Query: 327 SVALPPP-------PGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPP 371
             + PP        P PPP PPLP   PPPPPPPPP P     VPPPPPPPP PP
Sbjct: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 27/60 (45%), Positives = 31/60 (51%), Gaps = 9/60 (15%)

Query: 289 PGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPP 348
           P L  + +P   P   G +  P  PPPPPP   GP      +PPPP PPPPPP    GPP
Sbjct: 566 PPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGP------VPPPPPPPPPPP---GGPP 616


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 56/131 (42%), Positives = 96/131 (73%), Gaps = 5/131 (3%)

Query: 137 QEELEIQRRQLQEQQRQ-KELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           QEE   ++R+LQE++ Q ++LER+ L RER E E+ +++RL RE+  R + E+E+ E++ 
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEERREQQE 319

Query: 196 QERERQERLERQ-ERLERQERLERQERLDRE-RQERQERERLERLERERQERERQEQLER 253
           + RE+QER E+Q ER E+Q R E++ER +++ R+E++E  R ++L RE++E  R++QL R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379

Query: 254 EQLEWERERRI 264
           EQ +  RE+++
Sbjct: 380 EQ-QLRREQQL 389



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 53/125 (42%), Positives = 87/125 (69%), Gaps = 4/125 (3%)

Query: 141 EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERER 200
           E ++ Q +E QRQ+EL+ E  +  ++ER+ L RER E E+ +++RL +EQ  R +QE ER
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEER 314

Query: 201 QERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERERQEQLEREQLEWE 259
           +E  +++ER E+QER E+QE R +++ +  QE  R ++L RE++E  R++QL REQ E  
Sbjct: 315 RE--QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372

Query: 260 RERRI 264
           RE+++
Sbjct: 373 REQQL 377



 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 59/143 (41%), Positives = 96/143 (67%), Gaps = 16/143 (11%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERE---RMERERLERERLERERLERE------RLE 187
           +EE + QRR+ Q++  Q+E E+E  +RE   R E E+L+ E  +R+R  +E      +LE
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 188 QEQLERERQERE-RQERLERQERLERQERLERQE-----RLDRERQERQERERLERLERE 241
           +++L RERQE E +Q+RL R+++L R++  ER+E     R  +ER+E+QE  R ++L RE
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342

Query: 242 RQERERQEQLEREQLEWERERRI 264
           ++ER R++QL REQ E  RE+++
Sbjct: 343 QEER-REQQLRREQEEERREQQL 364



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 52/146 (35%), Positives = 95/146 (65%), Gaps = 7/146 (4%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           +Q  +L  + Q    QEE   +RR+ QE++R+++  RE+ E  R ++ R E+E    ++L
Sbjct: 295 QQQQRLRREQQLRRKQEE---ERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351

Query: 182 ERERLEQ---EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERE-RLER 237
            RE+ E+   +QL RE++E  R+++L R+++L R+++L R+++L RE+Q R+E++ R E+
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411

Query: 238 LERERQERERQEQLEREQLEWERERR 263
             R  Q+  R++QL REQ E   E++
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQK 437



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 60/154 (38%), Positives = 97/154 (62%), Gaps = 15/154 (9%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE------RLERERMER--ERLER 173
           R+   L  + +    QE  E + ++ QE++R + L+RE      RL+RE+ ER  +RL+R
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 174 ERLERERLERERLEQEQLERERQERERQERL----ERQERLERQERLERQERLDRERQER 229
           E  E ERLE+E   +++L+RE  E ER+++L    E++ER ++Q R E+QER ++  +  
Sbjct: 605 E--EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 230 QERERLE-RLERERQERERQEQLEREQLEWERER 262
           +E ERLE RL+RE +E  R+++L  E+ E  RER
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARER 696



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 56/134 (41%), Positives = 89/134 (66%), Gaps = 7/134 (5%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           +E LE++R+  +E+Q+Q+   ++R+ +E  E+E  +RE + R+  E+ + E+ Q +RE Q
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 197 ERERQ-ERLERQE-RLERQERLERQERLDRERQ--ERQERERLERLERERQERERQEQLE 252
           E E Q  +LERQE R ERQE  ++Q+RL RE+Q   +QE ER E+ E  R+++ER+EQ E
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 253 ---REQLEWERERR 263
               +QL  E+E R
Sbjct: 333 ERREQQLRREQEER 346



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 67/196 (34%), Positives = 107/196 (54%), Gaps = 19/196 (9%)

Query: 79  QWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
           +WR    V       KE+  +         E+   +E    L RQ  +   Q +    Q 
Sbjct: 245 EWRKRETVL-----RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299

Query: 139 ---ELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE----RLEQEQL 191
              E +++R+Q +E++ Q+E  RE+ ER   + ER E++ L RE+ ER     R EQE+ 
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ-LRREQEERREQQLRREQEEE 358

Query: 192 ERERQERERQERLERQERLERQERLERQERLDRERQERQERE--RLERLERERQERERQE 249
            RE+Q R  QE   R+++L R+++L R+++L RE+Q R+E++  R ++L RE+Q R R++
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQ 417

Query: 250 QLEREQ---LEWERER 262
           QL REQ    E E ER
Sbjct: 418 QLRREQQLRREQEEER 433



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/146 (36%), Positives = 97/146 (66%), Gaps = 7/146 (4%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER--ERLERERLERE 179
           R+  QL  + Q    +E+ E +R Q + +++Q+E   ++L RE+ ER  ++L RE+ E  
Sbjct: 301 RREQQLRRK-QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERE--RLER 237
           R ++ R EQE+ ER  Q+  R+++L R+++L R+++L R+++L RE+Q R+E++  R ++
Sbjct: 360 REQQLRREQEE-ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418

Query: 238 LERERQERERQEQLEREQLEWERERR 263
           L RE+Q R  QE+ ER + + E+ERR
Sbjct: 419 LRREQQLRREQEE-ERHEQKHEQERR 443



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 57/139 (41%), Positives = 91/139 (65%), Gaps = 13/139 (9%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLER-ERMERERLERERLERERLERERLE-------- 187
           +EE  +Q+R   EQQ ++E E  R +  +R E +RLE+ER E +RL+RE+ E        
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKR 581

Query: 188 QEQLERERQERERQERLERQERLERQERLERQERLDR--ERQERQERERLERLERERQER 245
           +E+  ++R +RE++ERLE++ + E  ERLE++ER ++  +R+E +E  R + L+ E QE 
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 246 ERQEQLEREQLEWERERRI 264
            RQ+QL REQ E  RE+R+
Sbjct: 642 RRQQQLRREQQE-RREQRL 659



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 53/146 (36%), Positives = 93/146 (63%), Gaps = 5/146 (3%)

Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
           P++  +L  + +     E  E++R + +E+Q+Q+ L RE+  R + E ER  RE+ E  R
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERR 322

Query: 181 LERERLEQEQLERERQ-ERERQERLERQERLER-QERLERQERLDRERQERQERERLERL 238
            ++ER EQ++  RE+Q  RE++ER E+Q R E+ +ER E+Q R ++E + R+++ R E+ 
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 239 ERERQERERQEQLEREQLEWERERRI 264
            R  Q+  R++QL REQ +  RE+++
Sbjct: 383 LRREQQLRREQQLRREQ-QLRREQQL 407



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 50/142 (35%), Positives = 94/142 (66%), Gaps = 4/142 (2%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           +Q  +   Q +    +E  E Q R+ QE++R+++L RE+ E ER E++ L RE+ E ER 
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQ-EEERREQQ-LRREQ-EEERR 373

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
           E++   ++QL RE+Q R R+++L R+++L R+++L R+++L RE+Q R+E++     E E
Sbjct: 374 EQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432

Query: 242 RQERERQEQLEREQLEWERERR 263
           R E++ +++   ++L+ E+E R
Sbjct: 433 RHEQKHEQERREQRLKREQEER 454



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/153 (37%), Positives = 96/153 (62%), Gaps = 11/153 (7%)

Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERE-RLERERLER 178
           L R+  +   Q+     ++ LE +RR+ + ++ Q+E   + L+RE   R+ RL+RE+ ER
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597

Query: 179 --ERLERE---RLEQEQLERERQERERQERLERQERLERQERLER-QERLDRERQERQER 232
             +RL+RE   RLEQE+   +R +RE  E   RQ+ L+ +E+ ER Q++L RE+QER+E 
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE- 656

Query: 233 ERLERLERERQERERQEQLEREQLEWERERRIS 265
              +RL+RE +E   +++L+RE  E  RE+ ++
Sbjct: 657 ---QRLKREEEEERLEQRLKREHEEERREQELA 686



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 57/135 (42%), Positives = 86/135 (63%), Gaps = 11/135 (8%)

Query: 137  QEELEIQRRQLQEQQ--RQKELERERLERERMERERLERERLERERLERERLEQE--QLE 192
            +EE E +RRQ +E+Q   ++EL++E  +  R ERE+  R+ LER+  E E ++QE  QL 
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 193  RERQERERQERLERQERLERQERLERQERLDRERQE--RQERERLERLERERQERERQEQ 250
            RE  E+ R++ LERQ R E +E  + +E+L RE QE  RQERER  R E E Q ++R+++
Sbjct: 1155 REEPEKRRRQELERQYR-EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213

Query: 251  L----EREQLEWERE 261
                 +R  L+W+ E
Sbjct: 1214 YRDEDQRSDLKWQWE 1228



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 58/159 (36%), Positives = 93/159 (58%), Gaps = 18/159 (11%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQL----QEQQRQKELERERLERERMERER---LERE 174
            R+  +L  + +    +EEL+ +  QL    +E +R++ELER+  + E +++E    L  E
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 175  RLERERLERER---------LEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225
              +R R ERER          E+EQL RE +E+ R++ LERQ R E +E  + +E+L RE
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR-EEEEVQQEEEQLLRE 1156

Query: 226  RQERQERERLERLERERQE-RERQEQLEREQLEWERERR 263
              E++ R+ LER  RE +E ++ +EQL RE+ E  R+ R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 52/136 (38%), Positives = 90/136 (66%), Gaps = 10/136 (7%)

Query: 137 QEELEIQRRQLQEQQRQKELER----ERLERERMERERLERERLERERLERERLEQEQLE 192
           QE  E Q R+ QE++R++ L+R    ERL++     ++L RE+ ER     +R E+++LE
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559

Query: 193 RERQE---RERQERLERQERLERQERLERQERLDRERQER-QERERLERLERERQERERQ 248
           +ER+E   +  QE  ER+++L ++E   RQ+RL RE++ER ++R + E +ER  QE  R+
Sbjct: 560 QERREQRLKREQE--ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617

Query: 249 EQLEREQLEWERERRI 264
           ++L+RE+ E ER +++
Sbjct: 618 QRLKREEPEEERRQQL 633



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 46/158 (29%), Positives = 92/158 (58%), Gaps = 17/158 (10%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           +Q  +   Q++    +   +  RR+ +E++R+++L RE+ E  R ++ R E++    ++L
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389

Query: 182 ERE-RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
            RE +L +EQ  R  Q+  R+++L R+++L R+++L R++  +R  Q+ ++  R +RL+R
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449

Query: 241 ERQER----------------ERQEQLEREQLEWERER 262
           E++ER                 R++QL+R+Q E  RER
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 57/158 (36%), Positives = 88/158 (55%), Gaps = 14/158 (8%)

Query: 120  LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE--LERERLERERMERERLERERLE 177
            L ++  QL  + +    ++ELE Q R+ +E Q+++E  L  E  +R R ERER  RE  E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115

Query: 178  RERLERERLEQEQLERERQERERQERLERQERLE------------RQERLERQERLDRE 225
             ++ E + L +E+ +R RQE ERQ R E + + E            R++ LERQ R + E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175

Query: 226  RQERQERERLERLERERQERERQEQLEREQLEWERERR 263
             Q+ +E+   E  E+ RQERERQ + E E    +R++R
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213



 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 63/165 (38%), Positives = 93/165 (56%), Gaps = 26/165 (15%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE----------LERERLERERMERERL 171
            R+  QL  + +    +EE E +RRQ QE+Q ++E          L  ER +R R ERER 
Sbjct: 900  RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959

Query: 172  ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE--- 228
             R+  + ++ E + L +E  +R RQERE++ R E +E  + +E+L R+ER  R RQE   
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR-EEEELQQEEEQLLREEREKRRRQEWER 1018

Query: 229  --------RQERERLERLERER---QERERQEQLEREQLEWERER 262
                    +QE E+L R ERE+   QERERQ + E E+L+ E E+
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYR-EEEELQQEEEQ 1062



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 52/143 (36%), Positives = 85/143 (59%), Gaps = 6/143 (4%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R+  QL  + Q    Q+    Q  +  EQ+ ++E   +RL+RE+ ER    R+ L+RE  
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER----RDWLKREE- 462

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
           E ER EQE+ +++ +  + +ER ER  +LE +ER E+QER +++ +  QE  R +RL+R+
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522

Query: 242 RQERERQEQLERE-QLEWERERR 263
            +E   Q++L  E QL  E+E R
Sbjct: 523 EEEERLQQRLRSEQQLRREQEER 545



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 48/128 (37%), Positives = 86/128 (67%), Gaps = 3/128 (2%)

Query: 137  QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
            QE+L  +++ LQE++ + + E ER +R R E+ER  RE  + ++ E + L +E+ +R RQ
Sbjct: 896  QEQLRKEQQLLQEEEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954

Query: 197  ERERQERLERQERLERQERLERQERLDRERQERQERER-LERLERERQERERQEQLEREQ 255
            ERERQ R +++ + +++E+L  +E   R RQER+++ R  E L++E ++  R+E+ +R +
Sbjct: 955  ERERQYRKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 256  LEWERERR 263
             EWER+ R
Sbjct: 1014 QEWERQYR 1021



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 59/154 (38%), Positives = 97/154 (62%), Gaps = 20/154 (12%)

Query: 123  QNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER--ERLERER 180
            +  Q  A+ ++  SQEE ++ R + +E++R++E +R+  E E++ +ER E+   R ER+R
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360

Query: 181  LERER-----------LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
              RE            LE+EQ  R RQERER + L+ +++L  QER E+Q R DR+R+ R
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLR-RQERER-KFLKEEQQLRCQER-EQQLRQDRDRKFR 1417

Query: 230  QERERLERLERERQERERQEQLEREQLEWERERR 263
            +E ++L R ER+R+ RE ++Q+ R+    ERER+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQ----ERERK 1447



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 53/157 (33%), Positives = 94/157 (59%), Gaps = 7/157 (4%)

Query: 109  EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER 168
            ++L  ++  P   R+  QL  Q ++   +EE ++++ + ++Q R +E +R+  E E++ +
Sbjct: 1748 KILEEEQLRPE--REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805

Query: 169  ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
            ER E++   ++R  + R E+EQL+ E QE+  ++  +RQ R E  E+   QE+  RE QE
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE--EQFATQEKSRREEQE 1863

Query: 229  R-QERERLERLERERQERERQEQLEREQLEWERERRI 264
              QE E+  R ERER+ RE  E + R+Q E +R R++
Sbjct: 1864 LWQEEEQKRRQERERKLRE--EHIRRQQKEEQRHRQV 1898



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 53/154 (34%), Positives = 94/154 (61%), Gaps = 15/154 (9%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R+  QL    +    +  L+++  + +EQQ ++E +  R + ER E +RL+R+  E ERL
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE-QRLKRQE-EEERL 528

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER-------QERER 234
           ++    ++QL RE++ER  +E+L ++E  +R E+  R++RL RE++ER       +E  R
Sbjct: 529 QQRLRSEQQLRREQEER--REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586

Query: 235 LERLERERQERERQ----EQLEREQLEWERERRI 264
            +RL+RE++ER  Q    E++ER + E  RE+R+
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRL 620



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 68/175 (38%), Positives = 104/175 (59%), Gaps = 35/175 (20%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER----------ERMERERL 171
           R+  QL  + Q    QEE E   ++ ++++R++ L+RE+ ER          ER E+ER 
Sbjct: 414 RREQQLRREQQLRREQEE-ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472

Query: 172 --------ERERLER-------ERLERERLEQEQLERERQERERQERLERQERLER-QER 215
                   E ER ER       ER E++   ++QL RE++ER R++RL+RQE  ER Q+R
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER-REQRLKRQEEEERLQQR 531

Query: 216 LERQERLDRERQERQE----RERLERLERERQE-RERQEQLER--EQLEWERERR 263
           L  +++L RE++ER+E    RE  +RLE+ER+E R ++EQ ER  + L+ E ERR
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 52/131 (39%), Positives = 80/131 (61%), Gaps = 8/131 (6%)

Query: 141  EIQRRQLQEQQRQKELERERLERERM----ERERLERERLERERLERERLEQE--QLERE 194
            E ++R+LQE++RQ   E E  + E      ERE   R+ LER+  + E L+QE  QL RE
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096

Query: 195  RQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE-RERQEQLER 253
              E+ R++  ERQ R E +E  + +E+L RE +E++ R+ LER  RE +E ++ +EQL R
Sbjct: 1097 EPEKRRRQERERQCR-EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155

Query: 254  EQLEWERERRI 264
            E+ E  R + +
Sbjct: 1156 EEPEKRRRQEL 1166



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 55/162 (33%), Positives = 95/162 (58%), Gaps = 10/162 (6%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
            L SQE       +  QL  Q +     +E +  RRQ + QQR+++ +R+  E E++ +ER
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 171  LERERLERERLERERLEQEQLERERQER---ERQERLERQERLE--RQERLERQERLDRE 225
             E++   +ER  + RLE++++ R+ QER   E +++L RQE  +  RQER +R+ R D +
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER-DRKFREDEQ 1626

Query: 226  RQERQERERLERLERERQERERQEQLER----EQLEWERERR 263
              + +E ++L R ER+R+  E + QL R    +QL  +R+R+
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 54/155 (34%), Positives = 90/155 (58%), Gaps = 5/155 (3%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPS-QEELEIQRRQLQEQQRQKELERERLERERMERE 169
            L  QE       +  QL  Q +     QEE +++R++L+ + R++E  R+  E+E++ R+
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743

Query: 170  RLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE-RQE 228
               R+ LE E+L  ER E++QL   RQER+R+ R E Q R ER+E+  R +  DR+ R+E
Sbjct: 1744 ERYRKILEEEQLRPER-EEQQLR--RQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800

Query: 229  RQERERLERLERERQERERQEQLEREQLEWERERR 263
             Q R+  E  +   Q+R+ + + E EQL+ E + +
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 55/149 (36%), Positives = 86/149 (57%), Gaps = 9/149 (6%)

Query: 120  LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE--LERERLERERMERERLERERLE 177
            L ++  QL  + +    ++E E Q R+  E Q+++E  L  ER +R   ERER  RE  E
Sbjct: 996  LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055

Query: 178  RERLERERLEQEQLERERQERERQ----ERLERQERLERQERLERQERLDRERQERQERE 233
             ++ E + L +E+  R RQE ERQ    E L+++E    +E  E++ R +RERQ R+E E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115

Query: 234  ---RLERLERERQERERQEQLEREQLEWE 259
                 E+L RE +E+ R+++LER+  E E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEE 1144



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 52/127 (40%), Positives = 81/127 (63%), Gaps = 8/127 (6%)

Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLE-RERLERERLEQEQLERERQ 196
           +E +++RR+L E +R+   E+++  RER +R   E E  E R+R    R E+E+L+ E  
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
           +R+R    E QE  E+  +LERQE L RERQE ++++  +RL RE+Q R +QE+  REQ 
Sbjct: 266 QRQR----ELQEEEEQLRKLERQE-LRRERQEEEQQQ--QRLRREQQLRRKQEEERREQQ 318

Query: 257 EWERERR 263
           E  RE++
Sbjct: 319 EERREQQ 325



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 60/163 (36%), Positives = 94/163 (57%), Gaps = 11/163 (6%)

Query: 122 RQNSQLPAQVQNGPSQE-ELEIQRRQLQEQQRQKELERER-LERERMERERLERERLERE 179
           R+  QL  + Q    Q+   E Q R+ Q+ +R+++L RE+ L RE+  R   E ER E++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERER---LE 236
             E+ER EQ     +R++ ER++ L+R+E  ER E+  R+++L R+ QE + RER   LE
Sbjct: 438 H-EQERREQRL---KREQEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLE 492

Query: 237 RLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNS 279
             ER  Q+  R++QL REQ E  RE+R+        ++  L S
Sbjct: 493 EEERREQQERREQQLRREQ-EERREQRLKRQEEEERLQQRLRS 534



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 55/142 (38%), Positives = 81/142 (57%), Gaps = 18/142 (12%)

Query: 137  QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
            +EEL+ +  QL  ++R+K   R R E ER  R++ E ++ E + L  ER ++   ERERQ
Sbjct: 993  EEELQQEEEQLLREEREK---RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049

Query: 197  ERERQERLERQERL-------ERQERLERQERLDRERQE------RQERERLERLERERQ 243
             RE +E  + +E+L        R++ LERQ R + E Q+      R+E E+  R ERERQ
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109

Query: 244  ERERQE--QLEREQLEWERERR 263
             RE +E  Q E + L  ERE+R
Sbjct: 1110 CREEEELQQEEEQLLREEREKR 1131



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 58/138 (42%), Positives = 84/138 (60%), Gaps = 12/138 (8%)

Query: 137  QEELEIQRRQLQEQQRQK----ELERERLERERMERERL-ERERLERERLERERLEQEQL 191
            +EE E +RRQ  E+Q +K    + E E+L RE  E+ RL ERER  RE  E ++ E+EQL
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ-EEEQL 1063

Query: 192  ERERQERERQERLERQERLERQERLERQE--RLDRERQERQERERLERLERERQERE--- 246
              E +E  R++ LERQ R E + + E ++  R + E++ RQERER  R E E Q+ E   
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123

Query: 247  -RQEQLEREQLEWERERR 263
             R+E+ +R + E ER+ R
Sbjct: 1124 LREEREKRRRQELERQYR 1141



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 59/142 (41%), Positives = 86/142 (60%), Gaps = 16/142 (11%)

Query: 137  QEELEIQRRQLQEQQRQKEL--ERERLERE----RMERERL---ERERLERERLERERLE 187
            ++EL+ +  QL  ++R+K    ERER  RE    + E E+L   ERE   R+ LER+  +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082

Query: 188  QEQLERERQE--RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
            +E+L++E ++  RE  E+  RQER ERQ R E + + + E+  R+ERE+  R E ERQ R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQER-ERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 246  ERQE-QLEREQL---EWERERR 263
            E +E Q E EQL   E E+ RR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRR 1163



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 56/173 (32%), Positives = 95/173 (54%), Gaps = 21/173 (12%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
            L  QE    L +   +   + +   S++E + + R+ ++Q R++E ER+ LE E+  R+ 
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458

Query: 171  LERERLERERLERERLEQE--QLERERQERERQERLERQER------------------L 210
              R+  E E+L +ER EQ+  + ER+R+  E +++L RQER                  L
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518

Query: 211  ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
            E +++L RQ+R  +  QE Q+  R ER ++ RQ+R+R+ + E EQL  ERE +
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR-EEEQLRQEREEQ 1570



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/153 (33%), Positives = 90/153 (58%), Gaps = 8/153 (5%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
            L+ QE       +  ++  Q Q     E+ +  RRQ  +QQ ++E +R+  E E++ +ER
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631

Query: 171  LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERL------ERQERLDR 224
             E ++L R+  +R+ LE+E   R RQERE+Q R +R  +   +E+L      ++  R +R
Sbjct: 1632 -EEQQLHRQERDRKFLEEEPQLR-RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689

Query: 225  ERQERQERERLERLERERQERERQEQLEREQLE 257
            +R+ R+E ++L R ERER+  + ++QL R++LE
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 48/141 (34%), Positives = 81/141 (57%), Gaps = 7/141 (4%)

Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
           Q++    +E  E Q R+ Q+ +R+++L RE+  R   +  R ++ R E++    ++L +E
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422

Query: 190 QLERERQERERQERLERQERLERQERLERQERLD----RERQERQERERLERLERERQER 245
           Q  R  QE ER E+   QER E++ + E++ER D     E  ER E+ER ++  +  QE 
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482

Query: 246 ERQE---QLEREQLEWERERR 263
           ER+E   +LE E+   ++ERR
Sbjct: 483 ERRERWLKLEEEERREQQERR 503



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 56/152 (36%), Positives = 88/152 (57%), Gaps = 11/152 (7%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
            R+  QL  Q +    +EE E +RRQ +E+Q +K+ + ++ E + +  E  +R R ERE+ 
Sbjct: 931  REEEQLQ-QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989

Query: 182  ERE----RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER--QERERL 235
             RE    + E+EQL RE +E+ R++  ERQ R + + + E ++ L  ER++R  QERER 
Sbjct: 990  YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049

Query: 236  ERLERERQERERQ----EQLEREQLEWERERR 263
             R E E Q+ E Q    E+  R + E ER+ R
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYR 1081



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 27/177 (15%)

Query: 114 QETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER 173
           +E G    ++  +   ++  G  Q E + +  Q   Q+R +EL R+R E +  E  R E 
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190

Query: 174 ERLE------------------RERLE---RERLEQEQLERERQERERQERLERQER--- 209
           E+L+                  RE LE   + R E++Q  RERQ+R  QE  E++ R   
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250

Query: 210 --LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRI 264
             L ++E   ++E   R+R+ ++E E+L +LER+   RERQE+ E++Q    RE+++
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE-EQQQQRLRREQQL 306



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 48/148 (32%), Positives = 89/148 (60%), Gaps = 10/148 (6%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLER-------ERMERERLERERLERERLER--ERLE 187
           +EE E   ++ ++QQ +++ E ER ER       ER E++    ++L RE+ ER  +RL+
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520

Query: 188 QEQLERERQERERQERLERQERLERQERL-ERQERLDRERQERQERERLERLERERQERE 246
           +++ E   Q+R R E+  R+E+ ER+E+L +R+E    E++ R++R + E+ ER  Q  +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
           R+E+  +++L+ E+E R+        VE
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVE 608



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 59/150 (39%), Positives = 87/150 (58%), Gaps = 28/150 (18%)

Query: 137  QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE-------RLERERL--E 187
            ++E E Q+   QE+ R+  LE +++ R+  ER+ +E E+  R        R ER+R   E
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623

Query: 188  QEQL--ERERQERERQER----LERQERLERQERLERQERLDRERQERQ--------ERE 233
             EQL  ERE Q+  RQER    LE + +L RQER E+Q R DR+R+ R+        E +
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 234  RLERLERERQERERQEQLEREQLEWERERR 263
            +L R ER+R+ RE ++QL R+    ERER+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQ----ERERK 1708



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 53/132 (40%), Positives = 79/132 (59%), Gaps = 7/132 (5%)

Query: 138  EELEIQRRQLQEQQRQKELERERLERER---MERERLERERLERERLERERLEQ--EQLE 192
            EE +++R++   + R++E +  R ERER    E ++L R+ LER+  E E+L Q  EQ +
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 193  RERQERERQERLERQERLERQE-RLERQERLDRERQERQERERLERLERERQERERQEQL 251
              RQER R+   E Q R ER+E +L RQER  + R+E Q R+  E  +   QE +R+ + 
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR- 1798

Query: 252  EREQLEWERERR 263
            E EQL  ERE +
Sbjct: 1799 EEEQLRQEREEQ 1810



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 53/153 (34%), Positives = 90/153 (58%), Gaps = 16/153 (10%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER-LERER 180
            R+  QL  Q ++    EE     +QL+ Q+R ++   + L  +  ER+ LE E+ L R++
Sbjct: 1473 REEQQLHRQERDRKFLEE----EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 181  LERERLEQEQLERERQERERQERLERQERLERQERL--ERQE----RLDRERQERQERER 234
             +R+ L++EQ  R RQER +Q R +R  +   +E+L  ER+E    R +R+R+ R E ++
Sbjct: 1529 RQRKFLQEEQQLR-RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 235  LERLERERQERERQEQLER----EQLEWERERR 263
            + R E+ER+  E ++QL R    +QL  ER+R+
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 7/160 (4%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
            L  QE      ++  QL  Q      +EE ++++   QEQ R++E  R+ LE E++  ER
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 171  LERE--RLERERL--ERERLEQEQLERE--RQERERQERLERQERLERQE-RLERQERLD 223
             E++  R ER+R   E E+L QE+ E++   QE +R+ R E Q R ER+E +L  Q+R  
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819

Query: 224  RERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
            + R E ++ +  E+ +R RQER+RQ + E +    E+ RR
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 47/136 (34%), Positives = 80/136 (58%), Gaps = 14/136 (10%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           +E  E +R+QL + + Q+E  +++L RE+ ER     +RL+RE  E ERLEQ +L+RE +
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERRE---QRLKREE-EEERLEQ-RLKREHE 677

Query: 197 ERERQERLERQERLERQERLER-----QERLDRERQERQE----RERLERLERERQERER 247
           E  R++ L  +E+ + +ER++      Q +L+ E   RQ     R R +  +R RQE+E 
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 248 QEQLEREQLEWERERR 263
           + +    +L+W+ E R
Sbjct: 738 KRRRRESELQWQEEER 753



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 52/156 (33%), Positives = 89/156 (57%), Gaps = 14/156 (8%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
            R+  QL  Q ++    EE    RRQ +EQQ + + +R+  E E++ +E  E++   +ER 
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690

Query: 182  ERERLEQEQLERERQERE--RQERLERQERLERQERLERQERLDRERQERQERERLERL- 238
             + R E++QL R+ +ER+  ++E+  R++ LER+ R E Q R + E+++ + +ER  ++ 
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750

Query: 239  -------ERERQERERQEQ----LEREQLEWERERR 263
                   ERE Q+  RQE+     E EQL  ERE +
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 53/156 (33%), Positives = 82/156 (52%), Gaps = 20/156 (12%)

Query: 137 QEELEIQRRQLQEQQRQ-----------KELERERLERERMERERLERERLERERLERER 185
           QEE    R+Q +E+QR+            E  R+RL      RE+ ER+    ER +RE+
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808

Query: 186 L----EQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
                E+E+ +R RQ RER++ L+  E  E+ +R ER ++L  E    QE +     ER 
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ-----ERR 863

Query: 242 RQERERQEQLEREQLEWERERRISSAAAPASVETPL 277
           R + +R++Q  R QLE ER+RR  +  A  +++  L
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 31/169 (18%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-ERLERERLERER 180
           RQ  + P Q +    QE    Q R+L E + Q E +    +R+R  R E L R+R E + 
Sbjct: 127 RQLEEEPGQRRRQKRQE----QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE 182

Query: 181 LERERLEQEQLE----RERQERERQERLERQERLE---------RQERLERQERLDRERQ 227
            E  R E+EQL+     E +E   +E+L R+E LE         +Q+R ERQ+R+ +E +
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242

Query: 228 ERQERER-------LERLERERQERERQEQLEREQL------EWERERR 263
           E++ R+R        E+L+ E  +R+R+ Q E EQL      E  RER+
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 48/149 (32%), Positives = 85/149 (57%), Gaps = 12/149 (8%)

Query: 129 AQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE--------RER 180
           ++V + P ++E + +R++ +E++R++E E +  E ER  R++ E E+           E+
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776

Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
            ER R         R++RERQ R E +++ E++   E +E+  R RQ R+  + L+ LE 
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836

Query: 241 ER--QERERQEQLEREQ--LEWERERRIS 265
           E   Q RER +QL+ E+  L+ ++ERR S
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRS 865



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 56/142 (39%), Positives = 85/142 (59%), Gaps = 17/142 (11%)

Query: 137  QEELEIQRRQLQEQQRQKELERERLERE----RMERERLERERLERERLERERL----EQ 188
            ++E  +Q R+ Q+  RQ E +R+ LE E    R ERE+  R   +R+  E E+L    E+
Sbjct: 1623 EDEQLLQEREEQQLHRQ-ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 189  EQL---ERERQERERQERLERQER----LERQERLERQERLDRERQERQERERLERLERE 241
            +QL   ER+R+ RE +++L RQER    L+ +++L RQE   + R+E Q R+  E+ +  
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741

Query: 242  RQERERQEQLEREQLEWERERR 263
            RQER R + LE EQL  ERE +
Sbjct: 1742 RQERYR-KILEEEQLRPEREEQ 1762



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 57/140 (40%), Positives = 86/140 (61%), Gaps = 16/140 (11%)

Query: 137  QEELEIQRRQ---LQEQQRQKELERERLERERMERERLERE-RLERERLERERLEQEQL- 191
            +EE  +Q R+   L+ Q+R ++   E L  +   R+ LE E RL R+  ER+ L++EQ  
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399

Query: 192  ---ERE---RQERERQERLERQERLERQERLERQERLDRERQERQERER--LERLERERQ 243
               ERE   RQ+R+R+ R E +++L RQER +R+ R + ++  RQERER  LE  ++ RQ
Sbjct: 1400 RCQEREQQLRQDRDRKFR-EEEQQLSRQER-DRKFREEEQQVRRQERERKFLEEEQQLRQ 1457

Query: 244  ERERQEQLEREQLEWERERR 263
            ER R+ + E EQL  ERE +
Sbjct: 1458 ERHRKFR-EEEQLLQEREEQ 1476



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 55/161 (34%), Positives = 91/161 (56%), Gaps = 10/161 (6%)

Query: 109  EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERE---- 164
            E L  QE G     +  +L  Q +     +E +  R Q +EQQ +++ +R+  E E    
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424

Query: 165  RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQ-ERLD 223
            R ER+R  RE  E +++ R+  E++ LE E+Q R+ + R  R+E    QER E+Q  R +
Sbjct: 1425 RQERDRKFRE--EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482

Query: 224  RERQERQERERLERLERERQERE---RQEQLEREQLEWERE 261
            R+R+  +E ++L R ER+R+ RE   R ++ ER+ LE E++
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ 1523



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 56/168 (33%), Positives = 91/168 (54%), Gaps = 15/168 (8%)

Query: 111  LNSQETGPTLPRQNSQLPAQVQNGPSQEE-----LEIQRRQLQEQQRQKELERERLERER 165
            L+ QE       +  Q+  Q +     EE      E  R+  +E+Q  +E E ++L R+ 
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482

Query: 166  MERERLERER-LERERLERERLEQE--QLERERQERERQERLERQER----LERQERLER 218
             +R+ LE E+ L R+  +R+  EQE    E ER+  E +++L RQ+R    L+ +++L R
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542

Query: 219  QERLDRERQERQERERLE---RLERERQERERQEQLEREQLEWERERR 263
            QER  + RQ+R  + R E   R ERE Q+  RQE+  + +LE ++ RR
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 56/148 (37%), Positives = 84/148 (56%), Gaps = 22/148 (14%)

Query: 137 QEELEIQRR----QLQEQQRQKELERERLERERMERERLERERLERERLERERLE----- 187
           +EE ++QRR    QLQE++   + ++ER   +   R++  R +LE ER  R         
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894

Query: 188 -QEQLERERQE-RERQERLERQERLERQERLERQERLDRERQERQERERLERLERE---R 242
            QEQL +E+Q  +E +E L+R+ER E++ R E++ +   E Q +QE E+L R ERE   R
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREER-EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 243 QERERQ-------EQLEREQLEWERERR 263
           QERERQ       +Q E + L  E E+R
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKR 981



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 47/155 (30%), Positives = 89/155 (57%), Gaps = 10/155 (6%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERE-----RLERERL 176
            RQ  +   + +    QEE ++ R + +E++R++ELER+  E E +++E     R E E+ 
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREE-REKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161

Query: 177  ERERLERERLEQEQLERERQERERQERLERQERLERQ----ERLERQERLDRERQERQER 232
             R+ LER+  E+E+L++E ++  R+E+ +R++  ERQ    E L+RQ+R  R R E Q  
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221

Query: 233  ERLERLERERQERERQEQLEREQLEWERERRISSA 267
            +   + E E++   R  ++  +  E E+ R++  +
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 47/141 (33%), Positives = 85/141 (60%), Gaps = 13/141 (9%)

Query: 135 PSQEELEIQRRQLQEQQRQKELERERLERERMER-ERLERER------LERERLERERLE 187
           P +EE E +RRQ +E++++ +   E  + +R ER ++L+ E        ER R + +R +
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871

Query: 188 QE---QLERERQERERQ--ERLERQERLERQERLERQERLDRERQERQERERLERLERER 242
           Q+   QLE ER+ R      +   QE+L ++++L ++E  + +R+ER++R R E+ ER+ 
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ-ERQY 930

Query: 243 QERERQEQLEREQLEWERERR 263
           +E E+ +Q E + L  ERE+R
Sbjct: 931 REEEQLQQEEEQLLREEREKR 951



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 55/157 (35%), Positives = 91/157 (57%), Gaps = 10/157 (6%)

Query: 114  QETGPTLPRQNSQLPAQVQNGPSQEELEIQRR---QLQEQQRQKELERERLERERMERER 170
            QE       +  QL  +      +EE  +Q R   QL  Q+R ++   E  +  R ER+R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501

Query: 171  LERER-LERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
              RE+ L  +  ER+ LE+EQ +  RQ+R+R+  L+ +++L RQER  +Q R DR+R+ R
Sbjct: 1502 KFREQELRSQEPERKFLEEEQ-QLHRQQRQRKF-LQEEQQLRRQER-GQQRRQDRDRKFR 1558

Query: 230  QERE-RLERLERE--RQERERQEQLEREQLEWERERR 263
            +E + R ER E++  RQER+R+ +LE +++  + + R
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 58/161 (36%), Positives = 88/161 (54%), Gaps = 33/161 (20%)

Query: 135 PSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER-----LERERLE-RERLEQ 188
           P +E+ E Q R  + QQR++    E  E+E+  R+R ERE+      E E+L+ RER +Q
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848

Query: 189 EQLE----RERQERERQERLER---------QERLER----------QERLERQERLDRE 225
            Q E    +E QER R +   R         +ER  R          QE+L ++++L +E
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908

Query: 226 RQE---RQERERLERLERERQERERQEQLEREQLEWERERR 263
            +E   R+ERE+  R E+ERQ RE +EQL++E+ +  RE R
Sbjct: 909 EEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLREER 948



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 61/180 (33%), Positives = 99/180 (55%), Gaps = 36/180 (20%)

Query: 122  RQNSQL----PAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERE-R 175
            R+N Q      +Q+++  SQ++L+    + QE+ R++E  R ++ +R   E E+LERE +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 176  LERERLERERLEQEQLERE-------RQERERQERLERQERLERQER-LERQERLDRERQ 227
             E +R +R+  E++QL RE       RQE +R+ R E Q   ER+E+ L RQER  + R+
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364

Query: 228  ER-----------QERERLERLERER-----------QERERQEQLEREQLEWERERRIS 265
            E            +E +RL R ERER           QERE+Q + +R++   E E+++S
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 53/147 (36%), Positives = 81/147 (55%), Gaps = 19/147 (12%)

Query: 137 QEELEIQRRQLQEQQR----QKELERERLERERMERERLERERLERERL--ERERLEQEQ 190
           +E L   RRQ ++Q+R     ++LE E  +R R +R+  ERE  E E    ++ERLEQ  
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165

Query: 191 LERE-----RQERERQERLER---QERLERQERLERQERLDRE---RQERQERERLERLE 239
            +R      RQ +E QER ER   +E+L+  +  E +E  D E   R+E  E  R  R E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225

Query: 240 RERQERERQEQL--EREQLEWERERRI 264
           +++Q RERQ+++  E E+ EW +   +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETV 252



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 48/126 (38%), Positives = 74/126 (58%), Gaps = 8/126 (6%)

Query: 141  EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERE--RQER 198
            E + +QL  Q+R ++   E  +  R ERE+  R   +R+  E E+L QE  E++  RQER
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689

Query: 199  ERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEW 258
            +R+ R E +++L RQER ER+   + ++  RQE ER  R E + ++   QEQL R+    
Sbjct: 1690 DRKFR-EEEQQLRRQER-ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ---- 1743

Query: 259  ERERRI 264
            ER R+I
Sbjct: 1744 ERYRKI 1749



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 54/178 (30%), Positives = 93/178 (52%), Gaps = 36/178 (20%)

Query: 120  LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERME------------ 167
            L ++  QL  + Q    QE  E Q R+ +E QRQK  +R R E +R +            
Sbjct: 1176 LQQEEEQLLREEQEKRRQER-ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234

Query: 168  ----------RERLERERLERERLERERLEQEQLER---ERQERERQERLERQERLER-- 212
                      RE  +  +LE  +L R+R  Q+ L+    E+QER+R++   R ++ +R  
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293

Query: 213  --QERLERQERLDRERQERQERERLERLERERQERERQEQLER-----EQLEWERERR 263
              +E+LER+E+ + +R++R+ +E  + L  ER+E+ R+++ +R     EQL  ERE +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 51/136 (37%), Positives = 83/136 (61%), Gaps = 13/136 (9%)

Query: 137  QEELEIQ---RRQLQEQQRQKELERER--LERERMERERLERERLERERLERERLEQEQL 191
            +EEL  Q   R+ L+E+QR +  ERER  L+ E+  R +   ++L ++R  + R E++QL
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423

Query: 192  ERERQERERQERLERQERLERQER----LERQERLDRERQERQERERLERLERERQERER 247
             R  QER+R+ R E ++++ RQER    LE +++L +ER  +   E     ERE Q+  R
Sbjct: 1424 SR--QERDRKFR-EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480

Query: 248  QEQLEREQLEWERERR 263
            QE+ +R+ LE E++ R
Sbjct: 1481 QER-DRKFLEEEQQLR 1495



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 55/159 (34%), Positives = 85/159 (53%), Gaps = 21/159 (13%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER- 195
           + E + +RRQ Q ++ Q+E   +RL+RE  E ERLE +RL+RE  E ER EQE  E E+ 
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREE-EEERLE-QRLKREH-EEERREQELAEEEQE 691

Query: 196 QERER--------QERLE-----RQERLERQERLERQERLDRERQERQER--ERLERLER 240
           Q RER        Q +LE     RQ ++  + R +  +R  +E++E++ R    L+  E 
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751

Query: 241 ERQERERQEQLEREQL--EWERERRISSAAAPASVETPL 277
           ER  R++QE+ +R     +W+ E +        S   PL
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 23/166 (13%)

Query: 120  LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKEL---------ERERLERERMERER 170
            L ++  QL  + +    ++ELE Q R+ +E Q+++E           R+ LER+  E E 
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175

Query: 171  L--ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
            L  E E+L RE  E+ R E+E+  RE +E +RQ+R +R    +++  L+ Q   ++E   
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235

Query: 229  R--------QERERLERLE----RERQERERQEQLEREQLEWERER 262
            R        +E E+  +LE    R+RQ ++  + L  EQ E +RE+
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 49/133 (36%), Positives = 71/133 (53%), Gaps = 12/133 (9%)

Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQLERERQERE 199
           Q   L E++R +   +E L ++R + E   R      +LE E   R  Q++ E+ER+  E
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150

Query: 200 RQERLERQERLERQERLERQERLDRERQERQERERLERLE--------RERQERERQEQL 251
            +E+ E+QERLE+++R  R E L R+RQE QERE     E         E +E   +EQL
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210

Query: 252 -EREQLEWERERR 263
             RE LE  R+ R
Sbjct: 211 RRRELLELRRKGR 223



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 47/130 (36%), Positives = 79/130 (60%), Gaps = 13/130 (10%)

Query: 141  EIQRRQLQEQQRQKELERERLE-RERMERERLERERLERERLERERLEQEQLERERQERE 199
            E QR + QE++R+   E ++L  +ER ++ R +R+R  RE  E ++L +++ +R+ +E E
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEE 1436

Query: 200  RQERLERQERL----ERQERLERQERLDRERQERQERE--RLERLERERQERERQEQLER 253
            +Q R + +ER     E+Q R ER  +   E Q  QERE  +L R ER+R+  E ++QL R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496

Query: 254  EQLEWERERR 263
            +    ER+R+
Sbjct: 1497 Q----ERDRK 1502



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 47/174 (27%)

Query: 137  QEELEIQRRQ-LQEQQRQKE---LERERLERERMERERLERERLERERLERERLEQEQLE 192
            +EE E +RRQ L+ Q R++E    E E+L RE  E+ R ERER  RE  E +R +++Q  
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214

Query: 193  RERQER---------------------------------ERQERLERQERLERQERLERQ 219
            R+  +R                                 E  +  +RQ + + Q  L  Q
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274

Query: 220  ERLDRERQER--QERER----LERLERERQE----RERQEQLEREQLEWERERR 263
            +  DRE++ R  Q+R+R     E+LERE Q+    R+R+ Q E++ L  ERE +
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 54/201 (26%), Positives = 92/201 (45%), Gaps = 56/201 (27%)

Query: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER--------ERMERE 169
           P   R+   L ++ Q    Q++L  ++++ +EQ+ ++E E ERLE+        ER E+E
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684

Query: 170 RLERERLE-RERL-------------------------------ERERLEQEQLERER-- 195
             E E+ + RER+                               +R R EQE+  R R  
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 196 ------------QERERQERLERQERLERQERLER-QERLDRERQERQERERLERLERER 242
                       Q++E ++R +   + + +E+ ER ++RL      R++RER  R E ER
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ER 803

Query: 243 QERERQEQLEREQLEWERERR 263
           Q+RE++   E E+ E  R +R
Sbjct: 804 QQREQRFLPEEEEKEQRRRQR 824



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 15/55 (27%), Positives = 32/55 (58%), Gaps = 3/55 (5%)

Query: 211 ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS 265
           E++ R + +E L ++R++ +++ R E  +R+ +E   Q    R Q   E+ER ++
Sbjct: 98  EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR---RRQKRQEQERELA 149


>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
          Length = 953

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 125/495 (25%), Positives = 196/495 (39%), Gaps = 80/495 (16%)

Query: 134 GPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER---LERERLERERLEQEQ 190
           G   E   +Q  + +     +E ERER ERE  +RER ERER    ERER +RER  + +
Sbjct: 382 GGQYENFRVQYTETEPYHNYRERERER-ERENRQRER-ERERERDRERERRQRERERERE 439

Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
            ER+++ + R+E  ER ER +R E+ +RQ R DR+R++ +E+E+ +   R  Q   RQ +
Sbjct: 440 HERDKERQRRKEEWER-ERAKRDEK-DRQHR-DRDREKEREKEKGKPKPRSPQPPSRQAE 496

Query: 251 LEREQL-----------EWE-----------------------RERRISSAAAPASVETP 276
             +++            EW+                       R R+ S+++A AS  + 
Sbjct: 497 PPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSR 556

Query: 277 LNSVLGD-----SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALP 331
            +S         SS S     + S  +   S+     G  +              S +  
Sbjct: 557 SSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRS-----------RSRSFSSS 605

Query: 332 PPPGPPPPPPLPS--TGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPL 389
           P P P P P  PS  T   P PPP     +    P PPPAPP        A + E  +P 
Sbjct: 606 PSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKT--TAPVPEPTKPG 663

Query: 390 TGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMS 449
               A       R   R    S    G+    + +SS++ +        L  S +    S
Sbjct: 664 DPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRS--------LSVSSVSSVSS 715

Query: 450 ALLARRRRIAEKGSTIETEQKEDKGED-SEPVTSKASSTSTPEPTRKPWERTNTMNGSKS 508
           A            S+  +   ED   D + PV+S +S +  P  TRK   ++   +G K 
Sbjct: 716 A--------TSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKE 767

Query: 509 PVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRK 568
               R  S +  +         S  +P STP   P     Q   + +  +K  +L++   
Sbjct: 768 EKRKRDSSTQPPKSAKPPAGGKSSQQP-STPQQAPPGQPQQGTFVAHKEIKLTLLNKAAD 826

Query: 569 ELTKLKEELIDAIRQ 583
           + ++ + E  D  RQ
Sbjct: 827 KGSRKRYEPSDKDRQ 841



 Score = 36.2 bits (82), Expect = 0.087
 Identities = 58/250 (23%), Positives = 88/250 (35%), Gaps = 25/250 (10%)

Query: 134 GPSQEELEIQRRQLQEQQRQKELERERLERERMERER--------LERERLERERLERER 185
           GPSQEE   +     E+ R  E + +  + E  E  R         E +  E +R    R
Sbjct: 57  GPSQEE---EDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLR 113

Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
            E   + RE  E E    L+  E +  +     QE    +     + E+ E   RE  + 
Sbjct: 114 DEASSVTRELDEHE----LDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKA 169

Query: 246 ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQG 305
             Q   E+E LE  +E++              +  L +    +P   +  +    P+ + 
Sbjct: 170 GVQSVGEKESLEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDP---SDRKVRPRPTCRF 226

Query: 306 IVLGPLAPPPPPPL--PPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV--- 360
            + G            P    + + +L     P PP   P  GP P  P  P    V   
Sbjct: 227 FMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPPLGPHPLMPANPWGGPVVDE 286

Query: 361 --PPPPPPPP 368
             PPPPP PP
Sbjct: 287 ILPPPPPEPP 296



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 60/290 (20%), Positives = 108/290 (37%), Gaps = 33/290 (11%)

Query: 78  HQWRDARQVYGLN-------FGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQ 130
           H   D  Q  GL+        GS +D +  A      LE   S   GP+   +++   + 
Sbjct: 12  HSPEDEEQPQGLSDDDILRDSGSDQDLDG-AGVRASDLEDEESAARGPSQEEEDNH--SD 68

Query: 131 VQNGPSQEELEIQRRQLQEQQRQK-----ELERERLERERMERERLERERLERERLERER 185
            ++  S+ + + Q  ++ E  R       E E +  E +R    R E   + RE  E E 
Sbjct: 69  EEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRDEASSVTRELDEHEL 128

Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRER--QERQERERLERLERERQ 243
              E++  E     +++  E+    + +E+ E   R + +   Q   E+E LE  + +++
Sbjct: 129 DYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKAGVQSVGEKESLEAAKEKKK 188

Query: 244 ERERQE---------QLEREQLEWERERRISSAAA-----PASVETPLNSVLGDSSASEP 289
           E +  E          LE  +++   +R++            +    +N        ++ 
Sbjct: 189 EDDDGEIDDGEIDDDDLEEGEVKDPSDRKVRPRPTCRFFMKGNCTWGMNCRFIHPGVNDK 248

Query: 290 GLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPP 339
           G  +    A+     G    PL P P  P  P        + PPP P PP
Sbjct: 249 GNYSLITKADPFPPNGAP--PLGPHPLMPANPWGGPVVDEILPPPPPEPP 296



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 40/151 (26%), Positives = 54/151 (35%), Gaps = 6/151 (3%)

Query: 344 STGPPPPPPPPPLPNQVPPPPPPPPAPP-LPASGFFLASMSEDNRPLTGLAAAIAGAKLR 402
           ST PP    PP        P  P  APP  P  G F+A   E    L   AA     K  
Sbjct: 775 STQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAH-KEIKLTLLNKAADKGSRKRY 833

Query: 403 KVSRMEDTSFPSG--GNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAE 460
           + S  +  S P     N      +  +   GR   P P    G   +  A  A R+R   
Sbjct: 834 EPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLS 893

Query: 461 KGSTIETEQKEDKGEDSEP--VTSKASSTST 489
             S   ++     G+ S+P   ++K+   ST
Sbjct: 894 PQSKSSSKVTSVPGKASDPGAASTKSGKAST 924


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 58/140 (41%), Positives = 87/140 (62%), Gaps = 20/140 (14%)

Query: 132 QNGPSQEELEIQRRQLQ-------EQQRQKELERERLERERMERERLERERLERERL-ER 183
           Q  P +  LE +++QL+       E ++++  ER  LE E+  +  LE++R E+ERL + 
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386

Query: 184 ERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ 243
           ER EQE+ ERERQE+ER+ +LE +++LE+Q  LERQ       +E + R+ +ER E  ++
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQRELERQ-------REEERRKEIERREAAKR 439

Query: 244 ERERQEQLEREQLEWERERR 263
           E ERQ      QLEWER RR
Sbjct: 440 ELERQ-----RQLEWERNRR 454



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 52/131 (39%), Positives = 81/131 (61%), Gaps = 19/131 (14%)

Query: 139 ELEIQRRQLQEQQRQKE--------LERERLERERMERERLERERLERERLERERLEQEQ 190
           ELE +R+ L EQQR+++         E+ER ERER E+ER  +  LE++ LE++R    +
Sbjct: 364 ELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----E 418

Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
           LER+R+E ER++ +ER+E  +R+  LERQ +L+ ER  RQE   L     + QE     +
Sbjct: 419 LERQREE-ERRKEIERREAAKRE--LERQRQLEWERNRRQE---LLNQRNKEQEDIVVLK 472

Query: 251 LEREQLEWERE 261
            +++ LE+E E
Sbjct: 473 AKKKTLEFELE 483



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 7/136 (5%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R N +L  + Q    Q+  E +R    E+  Q+  ERER E+ER  +  LE++  ++  L
Sbjct: 360 RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQREL 419

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE----RERLER 237
           ER+R E+ + E ER+E  ++E LERQ +LE  ER  RQE L++  +E+++    + + + 
Sbjct: 420 ERQREEERRKEIERREAAKRE-LERQRQLE-WERNRRQELLNQRNKEQEDIVVLKAKKKT 477

Query: 238 LERERQE-RERQEQLE 252
           LE E +   +++ QLE
Sbjct: 478 LEFELEALNDKKHQLE 493



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 45/142 (31%), Positives = 79/142 (55%), Gaps = 6/142 (4%)

Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE 179
           L +Q  +     Q   +++E + + RQ QE++RQ ELE++ LE++R     LER+R E  
Sbjct: 373 LEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----ELERQREEER 427

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           R E ER E  + E ERQ +   ER  RQE L ++ + E+++ +  + +++     LE L 
Sbjct: 428 RKEIERREAAKRELERQRQLEWERNRRQELLNQRNK-EQEDIVVLKAKKKTLEFELEALN 486

Query: 240 RERQERERQEQLEREQLEWERE 261
            ++ + E + Q  R +L  +R+
Sbjct: 487 DKKHQLEGKLQDIRCRLTTQRQ 508



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/123 (30%), Positives = 74/123 (60%), Gaps = 14/123 (11%)

Query: 124 NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE--RLERERMERERLERERLERERL 181
           N+QL  +++   ++++L+ Q+    E+ +QKE ER+   LE+++ E +R  +ER      
Sbjct: 604 NNQLK-ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER------ 656

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
           +++ LE  Q E E Q   R  +L  +E+L+R+E +++++  ++ +QE Q  ++L RL  +
Sbjct: 657 DKQWLEHVQQEDEHQ---RPRKLHEEEKLKREESVKKKDGEEKGKQEAQ--DKLGRLFHQ 711

Query: 242 RQE 244
            QE
Sbjct: 712 HQE 714



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/152 (22%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 112 NSQETGPTLPRQ---NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERME 167
           + Q  G  +P +   N QL    QN   ++ L   +R L+ ++  ++  R++L+  E+  
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593

Query: 168 RERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQ 227
           R +L+   +   +L+  R    + + ++Q+    ERL+++E+  +   LE+Q+   + R 
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 228 ERQERERLERLERERQERERQEQLEREQLEWE 259
           + ++++ LE +++E + +  ++  E E+L+ E
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 28/116 (24%), Positives = 65/116 (56%), Gaps = 6/116 (5%)

Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE 197
           +E++I   QL      KEL     +++  +++ +E ERL+++  ER+ +E E+ + E Q 
Sbjct: 598 QEIDIFNNQL------KELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQR 651

Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
           R ++   +  E +++++  +R  +L  E + ++E    ++   E+ ++E Q++L R
Sbjct: 652 RAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR 707



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/141 (23%), Positives = 76/141 (53%), Gaps = 24/141 (17%)

Query: 139 ELEIQRRQLQEQQR-------QKELERERLERERMERERLERERLE--RERLERERLEQE 189
           E+   ++QLQE Q+       +K++  ++L++  +++  L R+ L   +  LE + L ++
Sbjct: 523 EITHLQQQLQESQQMLGRLIPEKQILNDQLKQ--VQQNSLHRDSLVTLKRALEAKELARQ 580

Query: 190 QLERERQERERQERLERQE------------RLERQERLERQERLDRERQERQERERLER 237
            L  +  E E++ R + QE             +  +++L++Q+ ++ ER +++E+ER + 
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER-KI 639

Query: 238 LERERQERERQEQLEREQLEW 258
           +E E+Q+ E Q + +    +W
Sbjct: 640 IELEKQKEEAQRRAQERDKQW 660



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 3/129 (2%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERER-LERE 179
           ++  +   Q Q    Q ELE Q  + +E +RQ+E ER + +ER    +  LER+R LE E
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE 450

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           R  R+ L   Q  +E+++    +  ++    E +   +++ +L+ + Q+ + R   +R E
Sbjct: 451 RNRRQEL-LNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509

Query: 240 RERQERERQ 248
            E   + R+
Sbjct: 510 IESTNKSRE 518



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 22/111 (19%), Positives = 58/111 (52%), Gaps = 16/111 (14%)

Query: 95  EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL-EIQRRQLQEQQRQ 153
           ++ ++F + +    E+ N Q+    L +Q S    +++    + ++ E+++++ + Q+R 
Sbjct: 598 QEIDIFNNQLKELREIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 154 KELERERLE-----------RERMERERLERERLERERLERERLEQEQLER 193
           +E +++ LE           R+  E E+L+RE   +++   E+ +QE  ++
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDK 704



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 12/118 (10%)

Query: 296 QPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355
           QP    S     +G +A      +PP  A A V +   P     P L S+   P    PP
Sbjct: 105 QPVAISSAPAFGMGGIAS-----MPPLTAVAPVPMGSIPVVGMSPTLVSS--VPTAAVPP 157

Query: 356 LPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 413
           L N  PP   P PA   PA+    +S    + P + L       KL+K    +  S P
Sbjct: 158 LANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQL-----NTKLQKAQSFDVASVP 210


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 58/140 (41%), Positives = 87/140 (62%), Gaps = 20/140 (14%)

Query: 132 QNGPSQEELEIQRRQLQ-------EQQRQKELERERLERERMERERLERERLERERL-ER 183
           Q  P +  LE +++QL+       E ++++  ER  LE E+  +  LE++R E+ERL + 
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386

Query: 184 ERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ 243
           ER EQE+ ERERQE+ER+ +LE +++LE+Q  LERQ       +E + R+ +ER E  ++
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQRELERQ-------REEERRKEIERREAAKR 439

Query: 244 ERERQEQLEREQLEWERERR 263
           E ERQ      QLEWER RR
Sbjct: 440 ELERQ-----RQLEWERNRR 454



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 52/131 (39%), Positives = 81/131 (61%), Gaps = 19/131 (14%)

Query: 139 ELEIQRRQLQEQQRQKE--------LERERLERERMERERLERERLERERLERERLEQEQ 190
           ELE +R+ L EQQR+++         E+ER ERER E+ER  +  LE++ LE++R    +
Sbjct: 364 ELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----E 418

Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
           LER+R+E ER++ +ER+E  +R+  LERQ +L+ ER  RQE   L     + QE     +
Sbjct: 419 LERQREE-ERRKEIERREAAKRE--LERQRQLEWERNRRQE---LLNQRNKEQEDIVVLK 472

Query: 251 LEREQLEWERE 261
            +++ LE+E E
Sbjct: 473 AKKKTLEFELE 483



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 7/136 (5%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R N +L  + Q    Q+  E +R    E+  Q+  ERER E+ER  +  LE++  ++  L
Sbjct: 360 RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQREL 419

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE----RERLER 237
           ER+R E+ + E ER+E  ++E LERQ +LE  ER  RQE L++  +E+++    + + + 
Sbjct: 420 ERQREEERRKEIERREAAKRE-LERQRQLE-WERNRRQELLNQRNKEQEDIVVLKAKKKT 477

Query: 238 LERERQE-RERQEQLE 252
           LE E +   +++ QLE
Sbjct: 478 LEFELEALNDKKHQLE 493



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 45/142 (31%), Positives = 79/142 (55%), Gaps = 6/142 (4%)

Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE 179
           L +Q  +     Q   +++E + + RQ QE++RQ ELE++ LE++R     LER+R E  
Sbjct: 373 LEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----ELERQREEER 427

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           R E ER E  + E ERQ +   ER  RQE L ++ + E+++ +  + +++     LE L 
Sbjct: 428 RKEIERREAAKRELERQRQLEWERNRRQELLNQRNK-EQEDIVVLKAKKKTLEFELEALN 486

Query: 240 RERQERERQEQLEREQLEWERE 261
            ++ + E + Q  R +L  +R+
Sbjct: 487 DKKHQLEGKLQDIRCRLTTQRQ 508



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/123 (30%), Positives = 74/123 (60%), Gaps = 14/123 (11%)

Query: 124 NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE--RLERERMERERLERERLERERL 181
           N+QL  +++   ++++L+ Q+    E+ +QKE ER+   LE+++ E +R  +ER      
Sbjct: 604 NNQLK-ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER------ 656

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
           +++ LE  Q E E Q   R  +L  +E+L+R+E +++++  ++ +QE Q  ++L RL  +
Sbjct: 657 DKQWLEHVQQEDEHQ---RPRKLHEEEKLKREESVKKKDGEEKGKQEAQ--DKLGRLFHQ 711

Query: 242 RQE 244
            QE
Sbjct: 712 HQE 714



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/152 (22%), Positives = 81/152 (53%), Gaps = 4/152 (2%)

Query: 112 NSQETGPTLPRQ---NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERME 167
           + Q  G  +P +   N QL    QN   ++ L   +R L+ ++  ++  R++L+  E+  
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593

Query: 168 RERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQ 227
           R +L+   +   +L+  R    + + ++Q+    ERL+++E+  +   LE+Q+   + R 
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 228 ERQERERLERLERERQERERQEQLEREQLEWE 259
           + ++++ LE +++E + +  ++  E E+L+ E
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 28/116 (24%), Positives = 65/116 (56%), Gaps = 6/116 (5%)

Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE 197
           +E++I   QL      KEL     +++  +++ +E ERL+++  ER+ +E E+ + E Q 
Sbjct: 598 QEIDIFNNQL------KELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQR 651

Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
           R ++   +  E +++++  +R  +L  E + ++E    ++   E+ ++E Q++L R
Sbjct: 652 RAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR 707



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/141 (23%), Positives = 76/141 (53%), Gaps = 24/141 (17%)

Query: 139 ELEIQRRQLQEQQR-------QKELERERLERERMERERLERERLE--RERLERERLEQE 189
           E+   ++QLQE Q+       +K++  ++L++  +++  L R+ L   +  LE + L ++
Sbjct: 523 EITHLQQQLQESQQMLGRLIPEKQILNDQLKQ--VQQNSLHRDSLVTLKRALEAKELARQ 580

Query: 190 QLERERQERERQERLERQE------------RLERQERLERQERLDRERQERQERERLER 237
            L  +  E E++ R + QE             +  +++L++Q+ ++ ER +++E+ER + 
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER-KI 639

Query: 238 LERERQERERQEQLEREQLEW 258
           +E E+Q+ E Q + +    +W
Sbjct: 640 IELEKQKEEAQRRAQERDKQW 660



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 3/129 (2%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERER-LERE 179
           ++  +   Q Q    Q ELE Q  + +E +RQ+E ER + +ER    +  LER+R LE E
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE 450

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           R  R+ L   Q  +E+++    +  ++    E +   +++ +L+ + Q+ + R   +R E
Sbjct: 451 RNRRQEL-LNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509

Query: 240 RERQERERQ 248
            E   + R+
Sbjct: 510 IESTNKSRE 518



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 22/111 (19%), Positives = 58/111 (52%), Gaps = 16/111 (14%)

Query: 95  EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL-EIQRRQLQEQQRQ 153
           ++ ++F + +    E+ N Q+    L +Q S    +++    + ++ E+++++ + Q+R 
Sbjct: 598 QEIDIFNNQLKELREIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 154 KELERERLE-----------RERMERERLERERLERERLERERLEQEQLER 193
           +E +++ LE           R+  E E+L+RE   +++   E+ +QE  ++
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDK 704



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 12/118 (10%)

Query: 296 QPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355
           QP    S     +G +A      +PP  A A V +   P     P L S+   P    PP
Sbjct: 105 QPVAISSAPAFGMGGIAS-----MPPLTAVAPVPMGSIPVVGMSPTLVSS--VPTAAVPP 157

Query: 356 LPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 413
           L N  PP   P PA   PA+    +S    + P + L       KL+K    +  S P
Sbjct: 158 LANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQL-----NTKLQKAQSFDVASVP 210


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 58/136 (42%), Positives = 92/136 (67%), Gaps = 8/136 (5%)

Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERL----ERERLERERLERERLEQEQLER 193
           ++ E +RR  +  Q++KE E+ERL R+  E +RL    E+ER E+ER E+ER EQE+ E+
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERL-RKAAEAKRLAEQREQERREQERREQERREQERREQ 710

Query: 194 ERQERERQERLERQERLERQERLERQERL-DRERQERQERERLERLERERQERERQEQLE 252
           ER+E+ERQ  L  QER   QERL+ +  L +RE+  R ++E+L+R   E++++E Q++L 
Sbjct: 711 ERREQERQ--LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 768

Query: 253 REQLEWERERRISSAA 268
             QL+ E+E++   AA
Sbjct: 769 ERQLQEEQEKKAKEAA 784



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 51/131 (38%), Positives = 85/131 (64%), Gaps = 14/131 (10%)

Query: 137 QEELEIQRRQLQEQQRQKELER-----------ERLERERMERERLERERLERERLERER 185
           QEE E + ++L ++++++E ER           E+ E+ER E+ER E+ER E+ER E+ER
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712

Query: 186 LEQEQLERERQERERQERLERQERLERQERLER--QERLDRERQERQERERLERLERERQ 243
            EQE+   E++ R  QERL+ +  L+ +E+  R  +E+L RE +E++++E  +RL  ERQ
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQ 771

Query: 244 ERERQEQLERE 254
            +E QE+  +E
Sbjct: 772 LQEEQEKKAKE 782



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 11/152 (7%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-------ERLERE 174
           R+  Q   +V+    +++ +I+++  Q  ++ ++ + ERL  E+ ++       E +E  
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 638

Query: 175 RLERERLERER-LEQEQLERERQERERQERLERQERLERQ---ERLERQERLDRERQERQ 230
           R + E   R R L+QE+ ER  QE  ++++ E QERL +    +RL  Q   +R  QER+
Sbjct: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698

Query: 231 ERERLERLERERQERERQEQLEREQLEWERER 262
           E+ER E+  RE++ RE++ QL  ++   E+ER
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQER 730



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 45/148 (30%), Positives = 92/148 (62%), Gaps = 5/148 (3%)

Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE-RERLERERLERERLEQ 188
           +++N   +EE E  RRQ  E+ +++ LE  +L+RE   R+ L+ RER+E+ + E+++  +
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600

Query: 189 EQLER--ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERE 246
           ++  +  E+ E+ ++ERL  +E+ +++   ++ E ++  R++ +E  RL  L++E +ER 
Sbjct: 601 QKFAQIDEKTEKAKEERL-AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659

Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
            QE L++++ E E+ER   +A A    E
Sbjct: 660 HQELLQKKK-EEEQERLRKAAEAKRLAE 686



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/115 (42%), Positives = 73/115 (63%), Gaps = 11/115 (9%)

Query: 130 QVQNGPSQEELE--IQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERE 184
           Q +    QE L    + ++L EQ+ Q+  E+ER E+ER E+ER E+ER E+ER    +  
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724

Query: 185 RLEQEQL--ERERQERERQERLER---QERLERQERLERQERLDRERQERQERER 234
           R EQE+L  ERE QERE+  RL++   Q  LE +++ E Q+RL  ERQ ++E+E+
Sbjct: 725 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL-AERQLQEEQEK 778



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 18/102 (17%)

Query: 191 LERERQERERQERLERQERLERQ----ERLERQERLDRERQER-----QERERLERLERE 241
           +E+ERQ  E   R E  E+L RQ    ++  R E +  +R+ER     Q RER+E+++ E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594

Query: 242 RQER---------ERQEQLEREQLEWERERRISSAAAPASVE 274
           ++++         E+ E+ + E+L  E+ ++ ++A     VE
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 636



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 22/75 (29%), Positives = 48/75 (64%), Gaps = 5/75 (6%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R+  +  A+ +    QE L+ +R +LQE+++   L++E+L+RE  E+++ E    E++RL
Sbjct: 713 REQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKE----EQQRL 767

Query: 182 ERERLEQEQLERERQ 196
              +L++EQ ++ ++
Sbjct: 768 AERQLQEEQEKKAKE 782


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 58/136 (42%), Positives = 92/136 (67%), Gaps = 8/136 (5%)

Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERL----ERERLERERLERERLEQEQLER 193
           ++ E +RR  +  Q++KE E+ERL R+  E +RL    E+ER E+ER E+ER EQE+ E+
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERL-RKAAEAKRLAEQREQERREQERREQERREQERREQ 706

Query: 194 ERQERERQERLERQERLERQERLERQERL-DRERQERQERERLERLERERQERERQEQLE 252
           ER+E+ERQ  L  QER   QERL+ +  L +RE+  R ++E+L+R   E++++E Q++L 
Sbjct: 707 ERREQERQ--LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 764

Query: 253 REQLEWERERRISSAA 268
             QL+ E+E++   AA
Sbjct: 765 ERQLQEEQEKKAKEAA 780



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 51/131 (38%), Positives = 85/131 (64%), Gaps = 14/131 (10%)

Query: 137 QEELEIQRRQLQEQQRQKELER-----------ERLERERMERERLERERLERERLERER 185
           QEE E + ++L ++++++E ER           E+ E+ER E+ER E+ER E+ER E+ER
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708

Query: 186 LEQEQLERERQERERQERLERQERLERQERLER--QERLDRERQERQERERLERLERERQ 243
            EQE+   E++ R  QERL+ +  L+ +E+  R  +E+L RE +E++++E  +RL  ERQ
Sbjct: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQ 767

Query: 244 ERERQEQLERE 254
            +E QE+  +E
Sbjct: 768 LQEEQEKKAKE 778



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 11/152 (7%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-------ERLERE 174
           R+  Q   +V+    +++ +I+++  Q  ++ ++ + ERL  E+ ++       E +E  
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 634

Query: 175 RLERERLERER-LEQEQLERERQERERQERLERQERLERQ---ERLERQERLDRERQERQ 230
           R + E   R R L+QE+ ER  QE  ++++ E QERL +    +RL  Q   +R  QER+
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694

Query: 231 ERERLERLERERQERERQEQLEREQLEWERER 262
           E+ER E+  RE++ RE++ QL  ++   E+ER
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQER 726



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 45/148 (30%), Positives = 92/148 (62%), Gaps = 5/148 (3%)

Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE-RERLERERLERERLEQ 188
           +++N   +EE E  RRQ  E+ +++ LE  +L+RE   R+ L+ RER+E+ + E+++  +
Sbjct: 537 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 596

Query: 189 EQLER--ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERE 246
           ++  +  E+ E+ ++ERL  +E+ +++   ++ E ++  R++ +E  RL  L++E +ER 
Sbjct: 597 QKFAQIDEKTEKAKEERL-AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655

Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
            QE L++++ E E+ER   +A A    E
Sbjct: 656 HQELLQKKK-EEEQERLRKAAEAKRLAE 682



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 49/115 (42%), Positives = 73/115 (63%), Gaps = 11/115 (9%)

Query: 130 QVQNGPSQEELE--IQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERE 184
           Q +    QE L    + ++L EQ+ Q+  E+ER E+ER E+ER E+ER E+ER    +  
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720

Query: 185 RLEQEQL--ERERQERERQERLER---QERLERQERLERQERLDRERQERQERER 234
           R EQE+L  ERE QERE+  RL++   Q  LE +++ E Q+RL  ERQ ++E+E+
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL-AERQLQEEQEK 774



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 22/75 (29%), Positives = 48/75 (64%), Gaps = 5/75 (6%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R+  +  A+ +    QE L+ +R +LQE+++   L++E+L+RE  E+++ E    E++RL
Sbjct: 709 REQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKE----EQQRL 763

Query: 182 ERERLEQEQLERERQ 196
              +L++EQ ++ ++
Sbjct: 764 AERQLQEEQEKKAKE 778


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 93/355 (26%), Positives = 148/355 (41%), Gaps = 85/355 (23%)

Query: 82  DARQVYGLNFGSKEDANV---FASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
           D  +V+ +   + +D+     F S + H L V N  E  P   +   +  +Q+    +  
Sbjct: 380 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 439

Query: 139 ELEIQRRQLQ---EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           + + + R LQ   E    + +++ ++E+   +   LE+ +L+ E   R  L+ E  + E 
Sbjct: 440 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEK-KLDSELTARHELQVEMKKMES 498

Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
             E++ Q+    ++ L  +++    E+ D E +  Q    + +L +E ++ +++      
Sbjct: 499 DFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMA---- 554

Query: 255 QLEWERERRISSAA--APASVET-----PLNSVLGDSSASEPGLQAASQPAETPSQQGIV 307
                    +S+AA   P SV +     P   + GDS    P   A    + TP      
Sbjct: 555 --------SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGD-STTP------ 599

Query: 308 LGPLAPPPPPPLPPGPAQASVALPP---------PPGP-------PPPPPLP-------- 343
             P  PPPPPP PP P    ++ PP         PP P       PPPPPLP        
Sbjct: 600 --PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSP 657

Query: 344 -------STGPPPP--------PPPPPLPNQ--VPPPPP--------PPPAPPLP 373
                  +  PPPP        PPPPPLP    +PPPPP        PPP PPLP
Sbjct: 658 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 712



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 66/237 (27%), Positives = 104/237 (43%), Gaps = 51/237 (21%)

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           ++E E L  + +++ + E+   +  E +++L+ +     + +++ ++ E    ++L+ L+
Sbjct: 449 QIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQ 508

Query: 240 RERQERERQEQ---LEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAAS- 295
            E+     ++Q    E++ LE E  +     A        L   L D+      L AA+ 
Sbjct: 509 GEKDALHSEKQQIATEKQDLEAEVSQLTGEVAK-------LTKELEDAKKEMASLSAAAI 561

Query: 296 -QPAETPSQQGIVLGPLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPS---- 344
             P   PS+  +   P APP P       P PP P  ++   PPPP PPPPPPLP     
Sbjct: 562 TVPPSVPSRAPV---PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618

Query: 345 TGPPPPP------PPPPLPNQ--VPPPPP------------------PPPAPPLPAS 375
           + PP  P      PPPPL     +PPPPP                   PP PPLP S
Sbjct: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGS 675



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 47/106 (44%), Positives = 52/106 (49%), Gaps = 22/106 (20%)

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPP-------PPPLPPGPAQASVALPPP--- 333
           S +S PG  A   P   P    I   P  PPP       PPP PP P +A +  PPP   
Sbjct: 656 SPSSLPGGTAIPPPPPLPGSARI---PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 712

Query: 334 --PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP----PPPAPPLP 373
             PG PPPPP P  GP  PPPPP +   +PPPPP     P AP LP
Sbjct: 713 GGPGIPPPPPFPG-GPGIPPPPPGM--GMPPPPPFGFGVPAAPVLP 755



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/92 (34%), Positives = 33/92 (35%), Gaps = 20/92 (21%)

Query: 276 PLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG 335
           PL    G      P    A  P   P   G   GP  PPPPP             P  PG
Sbjct: 684 PLPGSAGIPPPPPPLPGEAGMPPPPPPLPG---GPGIPPPPP------------FPGGPG 728

Query: 336 PPPPPPLPSTGPPPP-----PPPPPLPNQVPP 362
            PPPPP     PPPP     P  P LP  + P
Sbjct: 729 IPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTP 760



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 15/49 (30%), Positives = 30/49 (61%)

Query: 151  QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
            Q  KE ++ R   E+M R +L +E+ E+ERLE+++  ++ ++   +  E
Sbjct: 1138 QAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDE 1186



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 15/40 (37%), Positives = 32/40 (80%), Gaps = 2/40 (5%)

Query: 147  LQEQQRQKELERERLERERMERERLERERLERERLERERL 186
            ++E Q+++E E E++ R ++ +E+ E+ERLE+++ +RE+L
Sbjct: 1140 VKENQKRRETE-EKMRRAKLAKEKAEKERLEKQQ-KREQL 1177



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 13/34 (38%), Positives = 28/34 (82%), Gaps = 1/34 (2%)

Query: 143  QRRQLQEQQRQKELERERLERERMERERLERERL 176
            +RR+ +E+ R+ +L +E+ E+ER+E+++ +RE+L
Sbjct: 1145 KRRETEEKMRRAKLAKEKAEKERLEKQQ-KREQL 1177



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 20/149 (13%)

Query: 112  NSQETGPTLPRQNSQLPAQVQNGPS---QEELEIQRRQLQEQQRQKELERERLERERMER 168
            N Q+    + +Q S +   VQN P+   +++  +++     +  Q++  + R+    ME 
Sbjct: 1045 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1104

Query: 169  ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
              L +E  E    + ++L  E+   +         L     +  Q   E Q+R     +E
Sbjct: 1105 --LYKELGEYFLFDPKKLSVEEFFMD---------LHNFRNMFLQAVKENQKR-----RE 1148

Query: 229  RQERERLERLERERQERER-QEQLEREQL 256
             +E+ R  +L +E+ E+ER ++Q +REQL
Sbjct: 1149 TEEKMRRAKLAKEKAEKERLEKQQKREQL 1177


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 93/355 (26%), Positives = 148/355 (41%), Gaps = 85/355 (23%)

Query: 82  DARQVYGLNFGSKEDANV---FASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
           D  +V+ +   + +D+     F S + H L V N  E  P   +   +  +Q+    +  
Sbjct: 389 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 448

Query: 139 ELEIQRRQLQ---EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           + + + R LQ   E    + +++ ++E+   +   LE+ +L+ E   R  L+ E  + E 
Sbjct: 449 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEK-KLDSELTARHELQVEMKKMES 507

Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
             E++ Q+    ++ L  +++    E+ D E +  Q    + +L +E ++ +++      
Sbjct: 508 DFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMA---- 563

Query: 255 QLEWERERRISSAA--APASVET-----PLNSVLGDSSASEPGLQAASQPAETPSQQGIV 307
                    +S+AA   P SV +     P   + GDS    P   A    + TP      
Sbjct: 564 --------SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGD-STTP------ 608

Query: 308 LGPLAPPPPPPLPPGPAQASVALPP---------PPGP-------PPPPPLP-------- 343
             P  PPPPPP PP P    ++ PP         PP P       PPPPPLP        
Sbjct: 609 --PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSP 666

Query: 344 -------STGPPPP--------PPPPPLPNQ--VPPPPP--------PPPAPPLP 373
                  +  PPPP        PPPPPLP    +PPPPP        PPP PPLP
Sbjct: 667 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 721



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 66/237 (27%), Positives = 104/237 (43%), Gaps = 51/237 (21%)

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           ++E E L  + +++ + E+   +  E +++L+ +     + +++ ++ E    ++L+ L+
Sbjct: 458 QIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQ 517

Query: 240 RERQERERQEQ---LEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAAS- 295
            E+     ++Q    E++ LE E  +     A        L   L D+      L AA+ 
Sbjct: 518 GEKDALHSEKQQIATEKQDLEAEVSQLTGEVAK-------LTKELEDAKKEMASLSAAAI 570

Query: 296 -QPAETPSQQGIVLGPLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPS---- 344
             P   PS+  +   P APP P       P PP P  ++   PPPP PPPPPPLP     
Sbjct: 571 TVPPSVPSRAPV---PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 627

Query: 345 TGPPPPP------PPPPLPNQ--VPPPPP------------------PPPAPPLPAS 375
           + PP  P      PPPPL     +PPPPP                   PP PPLP S
Sbjct: 628 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGS 684



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 47/106 (44%), Positives = 52/106 (49%), Gaps = 22/106 (20%)

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPP-------PPPLPPGPAQASVALPPP--- 333
           S +S PG  A   P   P    I   P  PPP       PPP PP P +A +  PPP   
Sbjct: 665 SPSSLPGGTAIPPPPPLPGSARI---PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 721

Query: 334 --PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP----PPPAPPLP 373
             PG PPPPP P  GP  PPPPP +   +PPPPP     P AP LP
Sbjct: 722 GGPGIPPPPPFPG-GPGIPPPPPGM--GMPPPPPFGFGVPAAPVLP 764



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/92 (34%), Positives = 33/92 (35%), Gaps = 20/92 (21%)

Query: 276 PLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG 335
           PL    G      P    A  P   P   G   GP  PPPPP             P  PG
Sbjct: 693 PLPGSAGIPPPPPPLPGEAGMPPPPPPLPG---GPGIPPPPP------------FPGGPG 737

Query: 336 PPPPPPLPSTGPPPP-----PPPPPLPNQVPP 362
            PPPPP     PPPP     P  P LP  + P
Sbjct: 738 IPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTP 769



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 15/49 (30%), Positives = 30/49 (61%)

Query: 151  QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
            Q  KE ++ R   E+M R +L +E+ E+ERLE+++  ++ ++   +  E
Sbjct: 1147 QAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDE 1195



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 15/40 (37%), Positives = 32/40 (80%), Gaps = 2/40 (5%)

Query: 147  LQEQQRQKELERERLERERMERERLERERLERERLERERL 186
            ++E Q+++E E E++ R ++ +E+ E+ERLE+++ +RE+L
Sbjct: 1149 VKENQKRRETE-EKMRRAKLAKEKAEKERLEKQQ-KREQL 1186



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 13/34 (38%), Positives = 28/34 (82%), Gaps = 1/34 (2%)

Query: 143  QRRQLQEQQRQKELERERLERERMERERLERERL 176
            +RR+ +E+ R+ +L +E+ E+ER+E+++ +RE+L
Sbjct: 1154 KRRETEEKMRRAKLAKEKAEKERLEKQQ-KREQL 1186



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 20/149 (13%)

Query: 112  NSQETGPTLPRQNSQLPAQVQNGPS---QEELEIQRRQLQEQQRQKELERERLERERMER 168
            N Q+    + +Q S +   VQN P+   +++  +++     +  Q++  + R+    ME 
Sbjct: 1054 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1113

Query: 169  ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
              L +E  E    + ++L  E+   +         L     +  Q   E Q+R     +E
Sbjct: 1114 --LYKELGEYFLFDPKKLSVEEFFMD---------LHNFRNMFLQAVKENQKR-----RE 1157

Query: 229  RQERERLERLERERQERER-QEQLEREQL 256
             +E+ R  +L +E+ E+ER ++Q +REQL
Sbjct: 1158 TEEKMRRAKLAKEKAEKERLEKQQKREQL 1186


>gi|18426913 drebrin 1 isoform b [Homo sapiens]
          Length = 651

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)

Query: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
           +S ++H L +    N++  G T  + ++ +          E   I R Q  EQ +++E  
Sbjct: 143 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 192

Query: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
           R+  ER++   ER R E+ER+E+ER E+E  E+   ERE+Q  E + + +  E  E + R
Sbjct: 193 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 252

Query: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
           L+ Q      R E +E   +++ E E +E      Q      +   ++ER  S++A    
Sbjct: 253 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 311

Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
           V +P N   G    S   +     P  +PS       P+A      L         +  P
Sbjct: 312 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 366

Query: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
           PP PPPPPP   T  P P           P     P + PP    PP  P  PA      
Sbjct: 367 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 426

Query: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
             +E       +  A A A ++   +   +T   +    +  N   +A+S  D   GNG 
Sbjct: 427 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 486

Query: 437 LPLGGSGLMEEMSA 450
              G S L  E  A
Sbjct: 487 ---GASTLQGEPRA 497


>gi|18426915 drebrin 1 isoform a [Homo sapiens]
          Length = 649

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)

Query: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
           +S ++H L +    N++  G T  + ++ +          E   I R Q  EQ +++E  
Sbjct: 141 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 190

Query: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
           R+  ER++   ER R E+ER+E+ER E+E  E+   ERE+Q  E + + +  E  E + R
Sbjct: 191 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 250

Query: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
           L+ Q      R E +E   +++ E E +E      Q      +   ++ER  S++A    
Sbjct: 251 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 309

Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
           V +P N   G    S   +     P  +PS       P+A      L         +  P
Sbjct: 310 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 364

Query: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
           PP PPPPPP   T  P P           P     P + PP    PP  P  PA      
Sbjct: 365 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 424

Query: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
             +E       +  A A A ++   +   +T   +    +  N   +A+S  D   GNG 
Sbjct: 425 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 484

Query: 437 LPLGGSGLMEEMSA 450
              G S L  E  A
Sbjct: 485 ---GASTLQGEPRA 495


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 76/250 (30%), Positives = 116/250 (46%), Gaps = 29/250 (11%)

Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
           E  E +    ER+E        L  + Q+ E  E + +   LE+Q  ++R + LD  R+ 
Sbjct: 383 EDAETKNAALERVEELEENISHLSEKLQDTEN-EAMSKIVELEKQ-LMQRNKELDVVREI 440

Query: 229 RQERER----LERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
            ++       L ++ +E++E  +RQ  LE++  E E++  I         +  +  V+  
Sbjct: 441 YKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIK-IQKKGDGDIAILPVVAS 499

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGP-----AQASVALPPPPGPPP 338
            + S  G +  +  +  P+      GPL PPPPPPLPP        Q     PP P PPP
Sbjct: 500 GTLSM-GSEVVAGNSVGPTMGAASSGPL-PPPPPPLPPSSDTPETVQNGPVTPPMPPPPP 557

Query: 339 PPPLPSTGPPPPPPPPPLPNQVPPP-----PPPPPAPPLPASGFFLASMSEDNRPLTGLA 393
           PPP     PPPPPPPPP P  +P P     P PP APPLP++      +   + P     
Sbjct: 558 PPP----PPPPPPPPPP-PPPLPGPAAETVPAPPLAPPLPSA----PPLPGTSSPTVVFN 608

Query: 394 AAIAGAKLRK 403
           + +A  K++K
Sbjct: 609 SGLAAVKIKK 618



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 16/60 (26%), Positives = 36/60 (60%), Gaps = 1/60 (1%)

Query: 189  EQLERERQERERQERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERER 247
            +Q E E + R++QE+   ++ LE++  +E+Q+ +    + +RQ++E +  L R + +  R
Sbjct: 982  KQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNR 1041


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 121/482 (25%), Positives = 204/482 (42%), Gaps = 97/482 (20%)

Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
           L  Q +N  + E L+ Q++QLQ+QQ              RQ+ +E ++ ER R+E E+  
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413

Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
           RER +R+  E+E   RLE  Q  R  +ER + ER +  +R + +E+  + ERL  +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470

Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
           QE   L+ L++++Q+++ Q+Q +++ L  +R+      R ++ A  PA           +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
              + P   A S+P  T              P PP+P    QAS   P PPGP    PP 
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568

Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
                P   P    + ++VP  P   P P          S S  ++P   LAA  A    
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615

Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
              S   D + P   +  +A G     +   T  G GP P   + +  +  A      ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668

Query: 459 AEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPR 518
            ++ S+I T         S P  +  +S      +   WER++++  +    + +  S  
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLE 728

Query: 519 KNQIVFDNRSYDSLHRPKSTPLSQPS---------------ANGVQTEGLDYDRLKQDIL 563
           +N++   +       +P S+P+  P                A+  +  G D+  LK+  L
Sbjct: 729 RNRVGVSS-------KPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTL 781

Query: 564 DE 565
           DE
Sbjct: 782 DE 783


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 119/474 (25%), Positives = 201/474 (42%), Gaps = 89/474 (18%)

Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
           L  Q +N  + E L+ Q++QLQ+QQ              RQ+ +E ++ ER R+E E+  
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413

Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
           RER +R+  E+E   RLE  Q  R  +ER + ER +  +R + +E+  + ERL  +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470

Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
           QE   L+ L++++Q+++ Q+Q +++ L  +R+      R ++ A  PA           +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
              + P   A S+P  T              P PP+P    QAS   P PPGP    PP 
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568

Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
                P   P    + ++VP  P   P P          S S  ++P   LAA  A    
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615

Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
              S   D + P   +  +A G     +   T  G GP P   + +  +  A      ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668

Query: 459 AEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPR 518
            ++ S+I T         S P  +  +S      +   WER++++  +    + +  S  
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLE 728

Query: 519 KNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTE-------GLDYDRLKQDILDE 565
           +N++   +       +P S+P+  P       +         D+  LK+  LDE
Sbjct: 729 RNRVGVSS-------KPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDE 775


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 55/130 (42%), Positives = 79/130 (60%), Gaps = 5/130 (3%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER-LERERLEQEQLERE 194
           ++ E E +R+  +E+ RQ++ ERER   ++ ERER      ER++  ERER      +R 
Sbjct: 218 TETETERKRQTDRERDRQRKTERER--EKQAERERASERETERDKERERERDRDRDRDRR 275

Query: 195 RQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLER 253
           ++ERERQ   +RQ R ER    ER+    RER+  +ER R    ERER+ ERERQ + ER
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335

Query: 254 EQLEWERERR 263
           ++ E ERER+
Sbjct: 336 DR-EKERERK 344



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 58/133 (43%), Positives = 86/133 (64%), Gaps = 11/133 (8%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           Q + E  R++  E++R+K+ ERER      ER++ ERER ER+R +R+R ++ Q ERERQ
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDK-ERER-ERDR-DRDR-DRRQKERERQ 282

Query: 197 -ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ---ERERQEQLE 252
            +R+RQ R ER    ER+   +R+   +RER  ++ERER    ERERQ   ER+R+++ E
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERE 342

Query: 253 RE---QLEWERER 262
           R+   Q E +RER
Sbjct: 343 RKRKRQTEMDRER 355



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 56/121 (46%), Positives = 78/121 (64%), Gaps = 5/121 (4%)

Query: 145 RQLQEQQRQKELERER-LERERMERERLERERLERERLERERLEQEQLERERQ-ERERQE 202
           R+ +E++RQ + +R+R  ER+R    + ER+R ERER ERER  + + ERER+ ERERQ 
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQR-ERER-ERERNRKRERERERERERERQR 331

Query: 203 RLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLEREQLEWERE 261
             ER    ER+ + +RQ  +DRER  +  RE   + ERER+ ERER  Q  RE+ E ER+
Sbjct: 332 ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD 391

Query: 262 R 262
           R
Sbjct: 392 R 392



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 53/155 (34%), Positives = 85/155 (54%), Gaps = 5/155 (3%)

Query: 112 NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER- 170
           N QE      ++  +   + ++     E E +R    E +R+++ +RER  + + ERER 
Sbjct: 184 NRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERERE 243

Query: 171 --LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
              ERER      ER++  + + +R+R    RQ+  ERQ   +RQ R ER    +R+R+ 
Sbjct: 244 KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER 303

Query: 229 RQERERLERLERERQERERQEQLERE-QLEWERER 262
           ++ERER ER    ++ERER+ + ERE Q E ER+R
Sbjct: 304 QRERER-ERERNRKRERERERERERERQRETERDR 337



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 45/131 (34%), Positives = 75/131 (57%), Gaps = 4/131 (3%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           Q + E +R +  +++RQ++ ER R +    E+ R ER   ER+R +  + E    ER R+
Sbjct: 152 QRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211

Query: 197 -ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER---QERERQEQLE 252
            ERER+   E + + +     +RQ + +RER+++ ERER    E ER   +ERER    +
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271

Query: 253 REQLEWERERR 263
           R++ + ERER+
Sbjct: 272 RDRRQKERERQ 282



 Score = 82.8 bits (203), Expect = 8e-16
 Identities = 49/129 (37%), Positives = 76/129 (58%), Gaps = 5/129 (3%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER-LERERLEQEQLERER 195
           + E +  R++ +  +R +E ER+R  +   ERER    + ERER  ERER  Q + ER+R
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDR 337

Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
           + ERER+ + + +   ER  +  R+ R   ER+  +ERER  +  RER+ERER    +R+
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQ 397

Query: 255 QLEWERERR 263
           +   ERER+
Sbjct: 398 K---ERERQ 403



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 50/126 (39%), Positives = 75/126 (59%), Gaps = 8/126 (6%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLE------RERLERERLERERLEQEQ 190
           + E E +R++  E+ R+KE ER+R  +  M+RER        R + ERER ERER    Q
Sbjct: 322 ERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER-ERERERDRQ 380

Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER-QERERQE 249
             RER+ERER    +RQ+  ERQ   +R  + + E+Q  +E++R     RER +ERE+Q+
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK 440

Query: 250 QLEREQ 255
             ER++
Sbjct: 441 GRERDR 446



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 52/134 (38%), Positives = 75/134 (55%), Gaps = 9/134 (6%)

Query: 139 ELEIQRRQLQEQQRQKELERERLERERMERER---LERERLERERLERERLEQEQLERER 195
           E E +R+  +E+ RQ+E ER R +    E ER     R+R    + ERER    + ERER
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161

Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
           Q +RERQ + ER  + ER+    RQER +RERQ  +E +  +R     +ERER+ + E E
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETE 221

Query: 255 -----QLEWERERR 263
                Q + ER+R+
Sbjct: 222 TERKRQTDRERDRQ 235



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 54/133 (40%), Positives = 85/133 (63%), Gaps = 11/133 (8%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           ++ + E +R++  E+QR++E ERER  +   ERER ERER  +   ER+R ++ + +R+R
Sbjct: 291 TERDRETERKR--ERQRERERERERNRKRERERER-ERERERQRETERDREKERERKRKR 347

Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLER-LERERQ-ERERQEQ 250
           Q   +RER  +  R+ R  RQ   ER+   +R+RQ  +ERE  ER  +R+RQ ERERQ +
Sbjct: 348 QTEMDRERNRQTGREGR--RQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405

Query: 251 LERE-QLEWERER 262
            +R+ Q E E++R
Sbjct: 406 KDRDGQRETEKQR 418



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 56/146 (38%), Positives = 84/146 (57%), Gaps = 24/146 (16%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERL----------------ERERLERER 180
           + + + +R++  E+ RQKE ERE+  +ER ERER                 ERER     
Sbjct: 160 ERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETE 219

Query: 181 LERERLEQEQLERERQ---ERERQERLERQERLERQERLERQERLDRERQERQERERLER 237
            E ER  Q   ER+RQ   ERER+++ ER+   ER+   ER +  +RER   ++R+R ++
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERET--ERDKERERERDRDRDRDRRQK 277

Query: 238 LERERQ-ERERQEQLEREQLEWERER 262
            ERERQ +R+RQ + ER++ E ER+R
Sbjct: 278 -ERERQTDRKRQRRTERDR-ETERKR 301



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 52/142 (36%), Positives = 76/142 (53%), Gaps = 11/142 (7%)

Query: 133 NGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERERLEQE 189
           +G  +E    + R+ + ++RQ E E +R    R E++R  +    RER    E+ER  Q 
Sbjct: 50  DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109

Query: 190 QLERERQ-ERERQERLERQERLERQERLERQERLD----RERQERQERERLERLERERQ- 243
             ER+RQ E+ER  + ER+   ER+    R  + D    RERQ   E+ER  + +RERQ 
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169

Query: 244 --ERERQEQLEREQLEWERERR 263
             ER RQ++ ERE+   ER  R
Sbjct: 170 QTERNRQKEREREKNRQERRER 191



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 50/148 (33%), Positives = 77/148 (52%), Gaps = 7/148 (4%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER- 180
           R+  +   + +N   + E E +R   + + RQ + +RER  +   E+ER  +   ER+R 
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170

Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
            ER R ++ + E+ RQER  +ER   +E        ER    +RER+   E ER  + +R
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230

Query: 241 ERQ-----ERERQEQLEREQL-EWERER 262
           ER      ERER++Q ERE+  E E ER
Sbjct: 231 ERDRQRKTEREREKQAERERASERETER 258



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/132 (39%), Positives = 74/132 (56%), Gaps = 11/132 (8%)

Query: 141 EIQRRQLQEQQRQKELERERL-ERERMERERLERERLERERLERERLEQEQLERERQ--- 196
           E QR + +E++RQ + ER+R  E+ER  ++  ERE        R+R    Q ERERQ   
Sbjct: 96  ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155

Query: 197 --ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
             ERERQ   ERQ + ER  + ER+   ++ RQER+ERER    E + ++R  +   ERE
Sbjct: 156 EKERERQTDRERQRQTERNRQKERER--EKNRQERRERERQREKENKTEDRHSERGRERE 213

Query: 255 ---QLEWERERR 263
              + E E ER+
Sbjct: 214 RERETETETERK 225



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 50/128 (39%), Positives = 78/128 (60%), Gaps = 5/128 (3%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERER-LERERLERERLERERLEQEQLERER 195
           Q E E +R + ++++R++E ERER  +   ER+R  ERER  + + E +R    Q  RE 
Sbjct: 304 QRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREG 363

Query: 196 QERERQERLERQERLERQERLERQER-LDRERQERQERERLERLERERQERERQEQLERE 254
           + +  +ER ER+   +RQ   ER+ER  DR+R  ++ERER    +R+ Q RE ++Q ERE
Sbjct: 364 RRQAERER-ERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ-RETEKQRERE 421

Query: 255 QLEWERER 262
           + + E ER
Sbjct: 422 K-DRESER 428



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 49/132 (37%), Positives = 80/132 (60%), Gaps = 7/132 (5%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERER-LERERLERERLERERLEQEQLERER 195
           + E +  R++ + ++RQ++ E+ER  +   ER+R  E+ER  ++  ERE   + +  R+R
Sbjct: 82  RREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141

Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERE--RLERLERERQERERQEQ 250
           Q   +RER+ + + ++  ERQ   ERQ + +R RQ+ +ERE  R ER ERERQ RE++ +
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ-REKENK 200

Query: 251 LEREQLEWERER 262
            E    E  RER
Sbjct: 201 TEDRHSERGRER 212



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/132 (43%), Positives = 82/132 (62%), Gaps = 9/132 (6%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           ++ + E QR + +E++R ++ ERER ERER ERER      +RE+ ERER  + Q E +R
Sbjct: 297 TERKRERQRERERERERNRKRERER-ERER-ERERQRETERDREK-ERERKRKRQTEMDR 353

Query: 196 QERERQERLE--RQERLERQERLERQERLDRERQERQ-ERERLERLERERQ-ERERQEQL 251
            ER RQ   E  RQ   ER+   ER  +  RER+ER+ +R+R  + ERERQ E++R  Q 
Sbjct: 354 -ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412

Query: 252 ERE-QLEWERER 262
           E E Q E E++R
Sbjct: 413 ETEKQREREKDR 424



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 54/143 (37%), Positives = 79/143 (55%), Gaps = 17/143 (11%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER---LERERLEQEQLER 193
           Q + E  R++ +E+ RQKE ERE        R+R    + ERER    E+ER  Q   ER
Sbjct: 108 QTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER 167

Query: 194 ERQ-----ERERQERLERQERLERQERLERQERL-----DRERQERQERERLERLERERQ 243
           +RQ     ++ER+    RQER ER+ + E++ +      +R R+  +ERE     ER+RQ
Sbjct: 168 QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQ 227

Query: 244 ---ERERQEQLERE-QLEWERER 262
              ER+RQ + ERE + + ERER
Sbjct: 228 TDRERDRQRKTEREREKQAERER 250



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 44/128 (34%), Positives = 73/128 (57%), Gaps = 6/128 (4%)

Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE----- 197
           +RR+ +++ R+++  RER      ERER      +R+R E+ER  Q++ ERE +      
Sbjct: 80  ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETEREGERG 138

Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLE 257
           R+RQ   +R+   +R    ER+ + DRERQ + ER R +  ERE+  +ER+E+  + + E
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198

Query: 258 WERERRIS 265
            + E R S
Sbjct: 199 NKTEDRHS 206



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 48/135 (35%), Positives = 78/135 (57%), Gaps = 10/135 (7%)

Query: 136 SQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERERLERER---LERERLEQEQL 191
           +  E + Q  + ++++R++E  R ER ERER   +  + E    ER    ERER  + + 
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222

Query: 192 ERERQ---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ 248
           ER+RQ   ER+RQ + ER+   E+Q   ER    + ER + +ERER    +R+R+++ER+
Sbjct: 223 ERKRQTDRERDRQRKTERER--EKQAERERASERETERDKERERERDRDRDRDRRQKERE 280

Query: 249 EQLERE-QLEWERER 262
            Q +R+ Q   ER+R
Sbjct: 281 RQTDRKRQRRTERDR 295



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 15/173 (8%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
           ++ + E  R+  +E +RQ E ERER      ERER  +   ERE  ER+R    Q ERER
Sbjct: 349 TEMDRERNRQTGREGRRQAERERER------ERERDRQSAREREERERDRDRDRQKERER 402

Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQL 251
           Q   +R+ Q   E+Q   E+    ER     RER++++ RER    +RERQ +R+   Q 
Sbjct: 403 QTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER----DRERQTDRQAGRQR 458

Query: 252 EREQLEWERERRIS-SAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ 303
           +R  L      R + S    +    P   +   SS  +P   +   P   P++
Sbjct: 459 KRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAK 511



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 15/132 (11%)

Query: 140 LEIQRRQ--LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER-Q 196
           L+  RR+   QE  R++ L +   + +  +RER  ++  ER R      E+ Q ERE  +
Sbjct: 24  LDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRR------EKRQTERETDR 77

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLERE- 254
           +RER+   +R  + +R    +R    +RERQ  +ER+R    ER RQ ERER+ + E E 
Sbjct: 78  KRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER 137

Query: 255 ----QLEWERER 262
               Q + +RER
Sbjct: 138 GRDRQTDGQRER 149



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 23/82 (28%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
           Q+   +EE E  R + ++++R+++ E++R  +   E++R ERE+       RER  + + 
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQR-EREKDRESERGRERGREREK 438

Query: 192 ERERQERERQERLERQERLERQ 213
           ++ R ER+R+ + +RQ   +R+
Sbjct: 439 QKGR-ERDRERQTDRQAGRQRK 459


>gi|21071077 dishevelled-associated activator of morphogenesis 1
           [Homo sapiens]
          Length = 1078

 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 60/177 (33%), Positives = 82/177 (46%), Gaps = 35/177 (19%)

Query: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
           +E+ E+ R+E  E Q++LE++ER    +  ++E   +   +  E+LE+E  E ++ +Q  
Sbjct: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV 508

Query: 253 RE---QLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLG 309
            +   QL  E  RR   A+ P                  PG      P+  P        
Sbjct: 509 ADLTAQLH-ELSRRAVCASIPGG--------------PSPGAPGGPFPSSVPGSL----- 548

Query: 310 PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366
            L PPPPPPLP G             PPPPPPLP  GPPPPP PPPL   +PPP  P
Sbjct: 549 -LPPPPPPPLPGGML-----------PPPPPPLPPGGPPPPPGPPPLGAIMPPPGAP 593



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 21/92 (22%), Positives = 46/92 (50%), Gaps = 12/92 (13%)

Query: 201  QERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-----------E 249
            + + E +   +++E  ER+ R++ + +E++ERER  R  +E  E   +           E
Sbjct: 985  EAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGE 1044

Query: 250  QLEREQLEWERER-RISSAAAPASVETPLNSV 280
              +++  + +R R RI++    +S E P+  +
Sbjct: 1045 VFDKDLSKLKRNRKRITNQMTDSSRERPITKL 1076



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 17/69 (24%), Positives = 37/69 (53%), Gaps = 3/69 (4%)

Query: 138 EELEIQRRQLQEQQRQKELE---RERLERERMERERLERERLERERLERERLEQEQLERE 194
           E++  +  +LQ++  +KE E   + + + E M+     +E+LE+E  E ++++Q+  +  
Sbjct: 453 EKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLT 512

Query: 195 RQERERQER 203
            Q  E   R
Sbjct: 513 AQLHELSRR 521



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 16/59 (27%), Positives = 36/59 (61%), Gaps = 1/59 (1%)

Query: 137 QEELEIQRRQLQE-QQRQKELERERLERERMERERLERERLERERLERERLEQEQLERE 194
           +E+ E  R++  E QQ+ ++ ERE   + + + E ++     +E+LE+E  E +Q++++
Sbjct: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQ 507


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 48/128 (37%), Positives = 89/128 (69%), Gaps = 2/128 (1%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           +EE E ++R+ +++ ++ E + +R ++E+ ER R  +E  ERER E ER  +E+ ERER+
Sbjct: 92  KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE-ERKREERKERERK 150

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER-QERERQEQLEREQ 255
           + ER++  ER+ER +R+ +   ++  +R+ +ER+ER++ ER  +ER +ERER+E+ ER++
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210

Query: 256 LEWERERR 263
              ++E R
Sbjct: 211 ERKKKEER 218



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 47/118 (39%), Positives = 86/118 (72%), Gaps = 4/118 (3%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERERLEQEQLE 192
           S+E  E +R++ ++++ +KE ER++ ERE+ ERER ER++ ER+++   E ER E+E+ E
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKEEERKEKERKE 185

Query: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
           R+++ER R+ER + +ER ER+ER + +++ +  ++ERQ+  +    E+ER +RER+E+
Sbjct: 186 RKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKER 243



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 52/143 (36%), Positives = 96/143 (67%), Gaps = 17/143 (11%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERM-ERERLERERLER-------------ERL 181
           S+ + E + R+ ++++R+KE +RER ++E+  ER++ ERER +R             +R 
Sbjct: 57  SERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRK 116

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLE--RLE 239
           ++E+ E+ +  +E +ERER+E  +R+ER ER+ + E +E+ +RER+ER++RER +    E
Sbjct: 117 KKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKE 175

Query: 240 RERQERERQEQLEREQLEWERER 262
            ER+E+ER+E+ +RE+   ER++
Sbjct: 176 EERKEKERKERKKRERNRKERKK 198



 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 51/133 (38%), Positives = 96/133 (72%), Gaps = 9/133 (6%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERL-EQEQLERER 195
           + E EI+ R+  +++R+ E ++ER ERE+ +RER E+ER +RER ++E+  E+++ ERER
Sbjct: 40  EREREIETRKEGKKERESERKKERREREKRKRER-EKER-KRERGKKEKKGERKKEERER 97

Query: 196 QERERQERLERQERLERQERLERQER-----LDRERQERQERERLERLERERQERERQEQ 250
           ++R R++  +  E  E++++ E++ER       +ER+ ++ER+R ER ERER++ ER+++
Sbjct: 98  KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKE 157

Query: 251 LEREQLEWERERR 263
            ER++ + +RER+
Sbjct: 158 RERKERK-KRERK 169



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 59/165 (35%), Positives = 99/165 (60%), Gaps = 33/165 (20%)

Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERL----------ERERMERERLER-------- 173
           + G  + E E ++ + + ++R++E E+ER           ER++ ERER +R        
Sbjct: 49  KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108

Query: 174 -----ERLERERLERERLEQEQLERER-QERERQERLERQ-ERLERQERLERQERLDRER 226
                +R ++E+ ER R  +E  ERER +ER+R+ER ER+ ++ ER++  ER+ER  RER
Sbjct: 109 GEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER 168

Query: 227 -------QERQERERLERLERERQERERQEQLER-EQLEWERERR 263
                  +ER+E+ER ER +RER  +ER+++ ER E+ E ++ER+
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 48/127 (37%), Positives = 88/127 (69%), Gaps = 6/127 (4%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           +E+ E  R   + ++R+++ ER+R ER+  ER++ ERE+ ERER ER++ E++Q+  + +
Sbjct: 118 KEKKERGRTSKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKEE 176

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
           ER+ +ER ER++R    ER  ++ + +RER+ER+ER++ ER ++E +++ERQ+  +    
Sbjct: 177 ERKEKERKERKKR----ERNRKERKKERERKERRERKK-ERKKKEERKKERQKDRQTNWR 231

Query: 257 EWERERR 263
           E ER +R
Sbjct: 232 EKERGKR 238



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 38/95 (40%), Positives = 67/95 (70%), Gaps = 4/95 (4%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           ++E E + R+ +E+++  E E ER E+ER ER++ ER R ER++ ERER E+ + ++ER+
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK-ERERKERRERKKERK 213

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQE 231
           ++E +++ ERQ+  +RQ     +ER  RER+ER++
Sbjct: 214 KKEERKK-ERQK--DRQTNWREKERGKRERKERKK 245



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/93 (26%), Positives = 59/93 (63%), Gaps = 4/93 (4%)

Query: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
           RER       +E  ++ + ER+++ RER++R   +E+  ++ER +++++ +R+++ER+ +
Sbjct: 39  REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98

Query: 233 ERLERLERERQERERQEQLEREQLEWERERRIS 265
           +R     RE++ +E +E+ +R++ E +   R S
Sbjct: 99  KR----RREKENKEGEEKEKRKKKEKKERGRTS 127



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 27/75 (36%), Positives = 48/75 (64%), Gaps = 4/75 (5%)

Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
           Q G  +EE + + R+ ++++ +   ER++ ERER ER   ++ER ++E  ++ER +  Q 
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKK-ERERKERRERKKERKKKEERKKERQKDRQT 228

Query: 192 ---ERERQERERQER 203
              E+ER +RER+ER
Sbjct: 229 NWREKERGKRERKER 243



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 7/87 (8%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
           R+  Q+  + +    +E  E ++R+   ++R+K       ERER ER   ++ER ++E  
Sbjct: 166 RERKQVGEKEEERKEKERKERKKRERNRKERKK-------ERERKERRERKKERKKKEER 218

Query: 182 ERERLEQEQLERERQERERQERLERQE 208
           ++ER +  Q     +ER ++ER ER++
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 120/476 (25%), Positives = 199/476 (41%), Gaps = 97/476 (20%)

Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
           L  Q +N  + E L+ Q++QLQ+QQ              RQ+ +E ++ ER R+E E+  
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413

Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
           RER +R+  E+E   RLE  Q  R  +ER + ER +  +R + +E+  + ERL  +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470

Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
           QE   L+ L++++Q+++ Q+Q +++ L  +R+      R ++ A  PA           +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530

Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
              + P   A S+P  T              P PP+P    QAS   P PPGP    PP 
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568

Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
                P   P    + ++VP  P   P P          S S  ++P   LAA  A    
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615

Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
              S   D + P   +  +A G     +   T  G GP P   + +  +  A      ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668

Query: 459 AEKGSTIETEQKEDKGEDSEPVTS----------------KASSTSTPEPTRKPWERTNT 502
            ++ S+I T         S P  +                + +   TP+P   P +    
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGP 728

Query: 503 MNGSKSPVISRRDS--PRKNQIVFDNRSY----DSLHRPKSTPLSQPSANGVQTEG 552
            N S +P + R D    R + ++  +  +     SL R +    S+P ++ V + G
Sbjct: 729 PNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPG 784


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 44/131 (33%), Positives = 98/131 (74%), Gaps = 4/131 (3%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLER-ERLERERLEQEQLERE 194
           +Q E E ++ + + ++R++E E+ER +RER ++E+ +R++ ER +  ER+R E+E+  +E
Sbjct: 30  TQRESERKKERREREKRKREREKER-KRERGKKEKKKRKKRERGKERERKRKEREKQRKE 88

Query: 195 RQERERQERLERQERLERQE--RLERQERLDRERQERQERERLERLERERQERERQEQLE 252
           R+E+ER++R + +++ ER++  R ER+++ +R+ +ER+ ++R ER  ++R++++R+++ +
Sbjct: 89  RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148

Query: 253 REQLEWERERR 263
           RE+   +RER+
Sbjct: 149 REKERGKRERK 159



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 43/130 (33%), Positives = 95/130 (73%), Gaps = 4/130 (3%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERER---LERERLERERLEQEQLER 193
           + E + +RR+ ++++R++E ER+R   ++ +++R +RER    ER+R ERE+  +E+ E+
Sbjct: 33  ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92

Query: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
           ER++R+++++   +++  R+ER +++ER +RER+ +Q RER +R +R +++R ++ + E+
Sbjct: 93  ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRER-KRKKRRKKKRRKERKREK 151

Query: 254 EQLEWERERR 263
           E+ + ER+R+
Sbjct: 152 ERGKRERKRK 161



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 45/131 (34%), Positives = 98/131 (74%), Gaps = 4/131 (3%)

Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLER-ERLERERLERERLEQEQLERE 194
           S+ + E + R+ ++++R+KE +RER ++E+ +R++ ER +  ER+R ERE+  +E+ E+E
Sbjct: 34  SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93

Query: 195 RQERERQERLERQERLERQERLERQERLDRERQ--ERQERERLERLERERQERERQEQLE 252
           R++R+++++   +++  R+ER +++ER +RER+  +R+ER+R +R +++R+ +ER+ + E
Sbjct: 94  RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR-KERKREKE 152

Query: 253 REQLEWERERR 263
           R + E +R++R
Sbjct: 153 RGKRERKRKKR 163



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 42/143 (29%), Positives = 93/143 (65%), Gaps = 2/143 (1%)

Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLER--E 179
           R+  +   + +    +E  + ++++ ++++R KE ER+R ERE+  +ER E+ER +R  E
Sbjct: 41  REREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKE 100

Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
           + +RER ++ + ER++++  ++   E ++R ER+ +  R+++  +ER+  +ER + ER  
Sbjct: 101 KKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKR 160

Query: 240 RERQERERQEQLEREQLEWERER 262
           ++R++ ER+++ ER + E ++ER
Sbjct: 161 KKRKKEEREKKRERNRKERKKER 183



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 49/131 (37%), Positives = 97/131 (74%), Gaps = 8/131 (6%)

Query: 138 EELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
           +E E +R++ ++Q++++ E ER + ++E+ +RER +R R ER++ ++ER E+E+  ++R+
Sbjct: 73  KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKK-KKERKERERENKQRR 131

Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER----ERQEQLE 252
           ER+R++R +++ R ER+   ER +R +R+R++R++ ER ++ ER R+ER    ER+E+ E
Sbjct: 132 ERKRKKRRKKKRRKERKREKERGKR-ERKRKKRKKEEREKKRERNRKERKKERERKERRE 190

Query: 253 REQLEWERERR 263
           R++ E ++ERR
Sbjct: 191 RKK-ERKKERR 200



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 47/153 (30%), Positives = 97/153 (63%), Gaps = 9/153 (5%)

Query: 137 QEELEIQRRQLQEQQRQK----ELERERLERERMER----ERLERERLERERLERERLEQ 188
           ++E E QR++ +E++R+K    + +RER +R R ER    ER ERER  ++R ER+R ++
Sbjct: 79  RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138

Query: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQER-QERERLERLERERQERER 247
            + +R ++ +  +ER +R+ + +++++ ER+++ +R R+ER +ERER ER ER+++ ++ 
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198

Query: 248 QEQLEREQLEWERERRISSAAAPASVETPLNSV 280
           + + +  + + + +R+  S       E+  N V
Sbjct: 199 RRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 40/146 (27%), Positives = 93/146 (63%), Gaps = 5/146 (3%)

Query: 114 QETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER 173
           +E G    R+  +   Q +    +E  + ++ + + +++Q+     + ++ER ERER  +
Sbjct: 69  RERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128

Query: 174 ERLERERLER---ERLEQEQLERERQERER-QERLERQERLERQERLERQERLDRERQER 229
           +R ER+R +R   +R ++ + E+ER +RER +++ +++ER +++ER  ++ + +RER+ER
Sbjct: 129 QRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKER 188

Query: 230 QERERLERLE-RERQERERQEQLERE 254
           +ER++  + E R+++ER++  + +R+
Sbjct: 189 RERKKERKKERRKKKERKKDRKTDRQ 214



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 26/83 (31%), Positives = 54/83 (65%), Gaps = 2/83 (2%)

Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLER-LER 240
           E + +    + +   +RE + + ER+ER +R+   E++ + +R ++E+++R++ ER  ER
Sbjct: 16  ELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER 75

Query: 241 ERQERERQEQLEREQLEWERERR 263
           ER+ +ER++Q  +E+ E ER +R
Sbjct: 76  ERKRKEREKQ-RKERREKERRKR 97


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 57/134 (42%), Positives = 84/134 (62%), Gaps = 17/134 (12%)

Query: 145 RQLQEQQRQKELERERLERERMERER---LERERLERER---LERERLEQEQLERERQ-- 196
           ++L+E++ +KE ER+ +E+ER ERER    ERER ERER    ERER ++++ ERER+  
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERD 348

Query: 197 -------ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQ 248
                  ER+R    ER    +R+   +R +   R R++ ++RER    ERER+ ERER+
Sbjct: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE 408

Query: 249 EQLEREQLEWERER 262
            + ERE+ E ERER
Sbjct: 409 RERERER-ERERER 421



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 56/137 (40%), Positives = 82/137 (59%), Gaps = 9/137 (6%)

Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERER---MERERLERERLERERLERERLEQ 188
           + G  ++E +   ++ +E++R++E ERER ERER    ERER + +  ERER ER+R   
Sbjct: 294 EKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERER-ERDRDRD 352

Query: 189 EQLERER---QERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
              ER+R   +ER+R    ER     +     R++  DRER+  +ERER    ERER ER
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER-ER 411

Query: 246 ERQEQLEREQLEWERER 262
           ER+ + ERE+ E ERE+
Sbjct: 412 ERERERERER-EREREK 427



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 50/146 (34%), Positives = 83/146 (56%), Gaps = 26/146 (17%)

Query: 139 ELEIQRRQLQEQQRQKELE-RERLERERMERERLERERLERERLERERLEQEQLERERQE 197
           E+E  +R L  ++  K  +  ++LE E+ ++E+ ER+ +E+ER ERER  + + ERER+E
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERER--ERERERERRE 324

Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERER--------------- 242
           RER+   ER+   E++   ER+   DR+R + ++R+R    +R+R               
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384

Query: 243 ------QERERQEQLEREQLEWERER 262
                 +ERER+ + ERE+ E ERER
Sbjct: 385 REKSRDRERERERERERER-ERERER 409



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 42/127 (33%), Positives = 74/127 (58%), Gaps = 2/127 (1%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERER-MERERLERERLERERLERERLEQEQLERER 195
           +E  E +R + +E++R+KE ERER ERER  +R+R +    +R+R      ++E+     
Sbjct: 320 RERREREREREREREREKEKERER-ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378

Query: 196 QERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
           ++R R     R    ER+   ER+   +RER+  +ERER    ERER++ +++++ E E+
Sbjct: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438

Query: 256 LEWERER 262
             +ER +
Sbjct: 439 DAYERRK 445



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 37/110 (33%), Positives = 73/110 (66%), Gaps = 4/110 (3%)

Query: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ-ERERQERLE 205
           ++ ++ +++L    + + R   ++LE E+ ++E+ ER+ +E+E+ ERER+ ERER ER E
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERERERERER-ERRE 324

Query: 206 RQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
           R+   ER+   E+++  +RER+  ++R+R +  +R+R +RER    +RE+
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDR-DRERDRDRDRER 373



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 62/244 (25%), Positives = 107/244 (43%), Gaps = 43/244 (17%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER- 195
           + E E +R + +E++R++E ERER + ++ +RE  E +  ER +LER+  E+E   +ER 
Sbjct: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461

Query: 196 ---QERERQERLERQERLERQERLERQERLDRERQERQE--------------------R 232
              + RER++  E ++  ER+E  ER+  + +E +  +E                    +
Sbjct: 462 KNWEIRERKKTREYEKEAEREE--ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQ 519

Query: 233 ERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVE------------TPLNSV 280
           +RL   E+E +  ER  + E+E+LE  R+R ++        E             P    
Sbjct: 520 KRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQ 579

Query: 281 LGDSSASEPGLQAASQPAETP--SQQGIVLGPLAPPPPPPLPPGPAQASV---ALPPPPG 335
             +S   E   Q   +  E P   ++     P   P   P+   P+ +S    A P  PG
Sbjct: 580 EPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPG 639

Query: 336 PPPP 339
              P
Sbjct: 640 DESP 643



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 43/150 (28%), Positives = 78/150 (52%), Gaps = 18/150 (12%)

Query: 137 QEELEIQRRQLQEQQRQKELERER-LERERMERERLERERLERERLERERLEQEQLERER 195
           + E +  R + +E+ R ++ ER+R  +RER      +R R   +  +RER  + + ERER
Sbjct: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403

Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ--------- 243
           +   ERER+   ER+   ER+   +++   + + ++  ER +LER  RE++         
Sbjct: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463

Query: 244 ----ERERQEQLERE-QLEWERERRISSAA 268
               ER++  + E+E + E ER R ++  A
Sbjct: 464 WEIRERKKTREYEKEAEREEERRREMAKEA 493



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 41/126 (32%), Positives = 68/126 (53%), Gaps = 1/126 (0%)

Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
           +N       E  R + +E++R++E ERER      ERER      ERER + ++ ++E+ 
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436

Query: 192 ERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQL 251
           E +  ER + ER  R++    QERL+  E  +R++    E+E  ER E  R+E  ++ + 
Sbjct: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE-AEREEERRREMAKEAKR 495

Query: 252 EREQLE 257
            +E LE
Sbjct: 496 LKEFLE 501



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 44/118 (37%), Positives = 75/118 (63%), Gaps = 16/118 (13%)

Query: 156 LERERLERERMERE----RLERERLERERLERERLEQEQLERERQERERQERLERQERLE 211
           +E E  +R+ + RE    R   ++LE E+ ++E+ E++++E+ER+ERER+   ER    E
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERERERERER----E 321

Query: 212 RQERLERQERLDRERQERQERERLERLERER---QERERQEQLEREQLEWERERRISS 266
           R+ER ER+   +RER++ +ERER    +R+R   +ER+R    ER++   +R+R  SS
Sbjct: 322 RRER-EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR---DRDRERSS 375



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 48/147 (32%), Positives = 80/147 (54%), Gaps = 25/147 (17%)

Query: 133 NGPSQEELEIQRRQLQEQQRQ-----------------KELERERLERERMERERLERER 175
           N PSQE     R++ +E++                   KE +   +E E  +R+ + RE 
Sbjct: 223 NAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKE-DINAIEMEEDKRDLISRE- 280

Query: 176 LERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERL 235
           + + R   ++LE+E   + ++E+ERQE +E++ R   +ER   +ER +RER+  +ERER 
Sbjct: 281 ISKFRDTHKKLEEE---KGKKEKERQE-IEKERRERERERERERERRERERERERERERE 336

Query: 236 ERLERERQERERQEQLEREQLEWERER 262
           +  ERER ERER    +R + E +R+R
Sbjct: 337 KEKERER-ERERDRDRDRTK-ERDRDR 361



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 19/44 (43%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 332 PPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
           PP    PP  +P+   PP  PPP  P   PP PP  P  P+P S
Sbjct: 4   PPHLNRPPMGIPAL--PPGIPPPQFPGFPPPVPPGTPMIPVPMS 45



 Score = 36.6 bits (83), Expect = 0.067
 Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 2/67 (2%)

Query: 320 PPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPP--PLPNQVPPPPPPPPAPPLPASGF 377
           PP   +  + +P  P   PPP  P   PP PP  P  P+P  +  P P    P +   G 
Sbjct: 4   PPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGK 63

Query: 378 FLASMSE 384
            L +  +
Sbjct: 64  HLGARKD 70


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 56/131 (42%), Positives = 61/131 (46%), Gaps = 30/131 (22%)

Query: 270  PASVETPLNSVLGDSSASEPGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLPPGPA 324
            P +   PL  + G      P L  A+ P   P    GI L P  P    PPPPPLP    
Sbjct: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLP---- 982

Query: 325  QASVALPPPP-----GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP----- 366
                 +PPPP     G PPPPPLP  G PPP        PPPPPLP    PPPPP     
Sbjct: 983  --GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040

Query: 367  -PPAPPLPASG 376
             PP PPLP +G
Sbjct: 1041 IPPPPPLPGAG 1051



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 59/164 (35%), Positives = 72/164 (43%), Gaps = 45/164 (27%)

Query: 255 QLEWERERRISSAAAPA-SVETPLNSVLGDSSASEPGLQAASQPA--------------- 298
           + +   E  +SSA   + ++ +P      +SS+S PGL     P                
Sbjct: 836 EFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTA 895

Query: 299 --ETPSQQGIVLGPLAPPPPPPLP--------PGPAQASVALPPPPGP--PPPPPLPSTG 346
             + P  QG     + PPPPPPLP        P P    + LPP PG   PPPPPLP   
Sbjct: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952

Query: 347 PPPPPP--------PPPLPNQVPPPPPP------PPAPPLPASG 376
            PPPPP        PPPLP    PPPPP      PP PPLP +G
Sbjct: 953 IPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 53/117 (45%), Positives = 55/117 (47%), Gaps = 29/117 (24%)

Query: 289  PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
            P L  A  P   P    GI   P  P    PPPPPLP     P P      +PPPP    
Sbjct: 979  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1038

Query: 335  -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
             G PPPPPLP  G PPP        PPPPPLP    PPPPP      PP PPLP +G
Sbjct: 1039 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 53/117 (45%), Positives = 55/117 (47%), Gaps = 29/117 (24%)

Query: 289  PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
            P L  A  P   P    GI   P  P    PPPPPLP     P P      +PPPP    
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1082

Query: 335  -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
             G PPPPPLP  G PPP        PPPPPLP    PPPPP      PP PPLP +G
Sbjct: 1083 AGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 49/103 (47%), Positives = 51/103 (49%), Gaps = 24/103 (23%)

Query: 314  PPPPPLP-----PGPAQASVALPPPP-----GPPPPPPLPSTGPPPPPP--------PPP 355
            PPPPPLP     P P    V +PPPP     G PPPPPLP  G PPPPP        PPP
Sbjct: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1189

Query: 356  LPNQVPPPPPP------PPAPPLPASGFFLASMSEDNRPLTGL 392
            LP    PPPPP      PP PPLP  G   A       P TG+
Sbjct: 1190 LPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGI 1232



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 53/117 (45%), Positives = 54/117 (46%), Gaps = 29/117 (24%)

Query: 289  PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
            P L  A  P   P    GI   P  P    PPPPPLP     P P      +PPPP    
Sbjct: 1067 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPG 1126

Query: 335  -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
             G PPPPPLP  G PPP        PPPPPLP    PPPPP      PP PPLP  G
Sbjct: 1127 AGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1183



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 53/117 (45%), Positives = 54/117 (46%), Gaps = 29/117 (24%)

Query: 289  PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
            P L  A  P   P    GI   P  P    PPPPPLP     P P      +PPPP    
Sbjct: 1078 PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1137

Query: 335  -GPPPPPPLPSTGPPPPPP--------PPPLPNQVPPPPPP------PPAPPLPASG 376
             G PPPPPLP  G PPPPP        PPPLP    PPPPP      PP PPLP  G
Sbjct: 1138 AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVG 1194



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 50/111 (45%), Positives = 52/111 (46%), Gaps = 24/111 (21%)

Query: 289  PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
            P L  A  P   P    GI   P  P    PPPPPLP     P P      +PPPP    
Sbjct: 1122 PPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181

Query: 335  -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPPPPAPPLPASG 376
             G PPPPPLP  G PPP        PPPPPLP    PP P PP PP P +G
Sbjct: 1182 VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP-PGTG 1231



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 40/75 (53%), Positives = 42/75 (56%), Gaps = 18/75 (24%)

Query: 314  PPPPPLPPGPAQASVALPPPP-----GPPPPPPLPSTGPPPPPPPPPL---PNQVPPPPP 365
            PPPPPLP       V +PPPP     G PPPPPLP  G PPPPP P +   P   PP PP
Sbjct: 1174 PPPPPLP------GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227

Query: 366  P----PPAPPLPASG 376
            P    PP P LP SG
Sbjct: 1228 PGTGIPPPPLLPVSG 1242



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 47/118 (39%), Positives = 53/118 (44%), Gaps = 25/118 (21%)

Query: 289  PGLQAASQPAETPSQQGIVLGPLAP------PPPPPLP-----PGPAQASVALPPPPGPP 337
            P L  A  P   P   G+ + P  P      PPPPPLP     P P    + +PP P PP
Sbjct: 1166 PPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPP 1224

Query: 338  PPPPLPSTGPPPPP----PPPPLPNQVPPPPPPPP------APPLPASGFFLASMSED 385
             PP  P TG PPPP      PPL  QV     P P       PPLP SG F   M++D
Sbjct: 1225 LPP--PGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP-SGLFGLGMNQD 1279



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 69/296 (23%), Positives = 99/296 (33%), Gaps = 111/296 (37%)

Query: 182 ERERLEQEQLERERQERER-QERLERQERLERQERLERQERLDRERQERQE--RERLERL 238
           E  RLE  + E +    E  Q+R +  ++     + E Q  + ++ ++  E  R ++  L
Sbjct: 634 EEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAEL 693

Query: 239 ERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSV-LGDSSASEPGLQAASQP 297
           ER+    + +     + LE             AS +  L ++ L +       +  A   
Sbjct: 694 ERQYPALDTEVASGHQGLE---------NGVTASGDVCLEALRLEEKEVRHHRILEAKSI 744

Query: 298 AETPSQQGIVLGPLAP----PPPPPLPPG------------------PAQASVALPPPP- 334
             +P+++G VL  L P    P  PP PPG                  P + SV L     
Sbjct: 745 QTSPTEEGGVL-TLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQP 803

Query: 335 ----GPPPPPP--LPSTG------------------------------------PPP--- 349
                 PPPPP  L S G                                    PPP   
Sbjct: 804 TQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863

Query: 350 -------------PPPPPPLPNQ---------VPPPPP-------PPPAPPLPASG 376
                        PPPPPPLP           +P PPP       PPP PPLP +G
Sbjct: 864 TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAG 919



 Score = 36.6 bits (83), Expect = 0.067
 Identities = 36/148 (24%), Positives = 57/148 (38%), Gaps = 19/148 (12%)

Query: 230 QERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG-DSSASE 288
           Q+  RL++ ++++ + + Q+Q +++QL+   E     AA P +V     + LG D     
Sbjct: 200 QQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEE----PAAPPTAVSPQPGAFLGLDRFLLG 255

Query: 289 PGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPP 348
           P   A   P    ++Q   L  L+  P             +L   P  P  PP P   P 
Sbjct: 256 PSGGAGEAPGSPDTEQA--LSALSDLPE------------SLAAEPREPQQPPSPGGLPV 301

Query: 349 PPPPPPPLPNQVPPPPPPPPAPPLPASG 376
              P  P         P   A P P +G
Sbjct: 302 SEAPSLPAAQPAAKDSPSSTAFPFPEAG 329


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 89/331 (26%), Positives = 123/331 (37%), Gaps = 48/331 (14%)

Query: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS----SAAAPA 271
           LER  R+ R R   +       LE+  Q+R       +  + +    R+      A  PA
Sbjct: 51  LERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPA 110

Query: 272 SVETPLNSVLGDSSASEPGLQA---------ASQPAETPSQQGIVLGPLAPPPPPPLPPG 322
               P  +    ++A+ P   A         A+ PA  P  +       APP P P  PG
Sbjct: 111 PPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAP--RAAAAAATAPPSPGPAQPG 168

Query: 323 PAQ---ASVALPPP-PGPPP---PPPLPSTGPPP----------PPPPPPLPNQVPPPPP 365
           P     A +A PPP P  PP   PP  P   PPP          PPP PP P Q   PPP
Sbjct: 169 PRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPP 228

Query: 366 PPPAPPLPASGFFLA-------SMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNA 418
           P P PP P  G   A       S+ E  R L G   A       +V  + +    + G  
Sbjct: 229 PQPQPP-PEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRL 287

Query: 419 IGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSE 478
                 +     G   G  P          SA  +R +R  E+   +E E++ED  ED +
Sbjct: 288 ERTRLGALALPRGDRPGRAP-------PAASARPSRSKRGGEE-RVLEKEEEEDDDEDED 339

Query: 479 PVTSKASSTSTPEPTRKPWERTNTMNGSKSP 509
                +  +  PE  R    + + +NG + P
Sbjct: 340 EEDDVSEGSEVPESDRPAGAQHHQLNGERGP 370



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 60/190 (31%), Positives = 77/190 (40%), Gaps = 17/190 (8%)

Query: 160 RLERERMERERLERERLERERLERERLEQEQLER-ERQERERQERLERQERLER--QER- 215
           RL R R++   LE E   R RLER RL    L R +R  R       R  R +R  +ER 
Sbjct: 267 RLTRGRVQG-LLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERV 325

Query: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVET 275
           LE++E  D +  E +E +  E    E  E +R    +  QL  ER  +  SA       T
Sbjct: 326 LEKEEEEDDDEDEDEEDDVSEG--SEVPESDRPAGAQHHQLNGERGPQ--SAKERVKEWT 381

Query: 276 PLNSVLGDSSASEP----GLQAASQPAETPSQQG---IVLGPLAPPPPPPLPPGPAQASV 328
           P     G      P    G +     A    + G   +  GP + P P PLPPG      
Sbjct: 382 PCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDS-PSPVPLPPGKPALPG 440

Query: 329 ALPPPPGPPP 338
           A   P G PP
Sbjct: 441 ADGTPFGCPP 450


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 118/465 (25%), Positives = 186/465 (40%), Gaps = 60/465 (12%)

Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL--EIQRRQLQEQQRQKELERERLERERM 166
           E   S+E    +P Q  + P+ + N P +  L  +  R Q + ++R + L R++L +E+ 
Sbjct: 322 EYSGSEEEEEEVPEQEGE-PSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQ 380

Query: 167 ERERLE---------RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLE 217
            RE+ E         ++R+E+++ +R RLE++Q    R+ERE + + ER++R   QE   
Sbjct: 381 LREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ----RREREARRQQEREQRRREQEEKR 436

Query: 218 RQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPL 277
           R E L+R R+E +ER    R E E++  ER+++  R QLE E +R +         E  +
Sbjct: 437 RLEELERRRKEEEER---RRAEEEKRRVEREQEYIRRQLE-EEQRHLEVLQQQLLQEQAM 492

Query: 278 NSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337
             +L D     P  Q + QP   P Q+       AP P     P      V +      P
Sbjct: 493 --LLHDHRRPHP--QHSQQP-PPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSP 547

Query: 338 ----PPPPLPSTGPPPPPPPPPLPNQVPPP----PPPPPAPPLPASGFFLASMSEDNRPL 389
                  PL  +G                P           P P SG    S +  ++P 
Sbjct: 548 VLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPG 607

Query: 390 TGLAA-AIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGG----SGL 444
           +   + + +G + R  S  +    PS      V     K +  R   PL   G    + L
Sbjct: 608 SHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFR---PLKPAGEVDLTAL 664

Query: 445 MEEMSALLARR--RRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNT 502
            +E+ A+   R   ++ +  S+ E     D+ +D         STS PE TR      N 
Sbjct: 665 AKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA-SSLNL 723

Query: 503 MNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANG 547
            NG    V        K  IV D+         +S P   PS  G
Sbjct: 724 SNGETESV--------KTMIVHDD--------VESEPAMTPSKEG 752



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 119/502 (23%), Positives = 199/502 (39%), Gaps = 67/502 (13%)

Query: 131 VQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERE---------------- 174
           +++ P++ ++ IQ +   ++ R+K  E++  E E    E  E E                
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348

Query: 175 ---------RLERERLER-ERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
                    RL++E  ER E L ++QL +E+Q RE QE  +RQ   ERQ+R+E+Q+   R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLRE-QEEYKRQLLAERQKRIEQQKEQRR 407

Query: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS-----VETPLNS 279
             +E+Q RER  R ++ER++R R+++ +R   E ER R+       A      VE     
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467

Query: 280 VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPP 339
           +       +  L+   Q  +   +Q ++L     P P        Q S   PPP      
Sbjct: 468 IRRQLEEEQRHLEVLQQ--QLLQEQAMLLHDHRRPHP--------QHSQQPPPPQQERSK 517

Query: 340 PPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGA 399
           P   +  P     P     +V P      +P L      L    + N    G   + +  
Sbjct: 518 PSFHAPEPKAHYEPADRAREV-PVRTTSRSPVLSRRDSPLQGSGQQNSQ-AGQRNSTSSI 575

Query: 400 KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIA 459
           + R +    +   P  G+  G +S SS + +  G+ P    GSG   E   + +  +   
Sbjct: 576 EPRLLWERVEKLVPRPGS--GSSSGSSNSGSQPGSHPGSQSGSG---ERFRVRSSSKSEG 630

Query: 460 EKGSTIETEQK--EDKGEDSEP--------VTSKASSTSTPEPTRKPWERTNTMNGSKSP 509
                +E   K  EDK E   P        +T+ A      E  R P + T+  + S+  
Sbjct: 631 SPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEES 690

Query: 510 VISRRDSPRKNQIVFDNRSYDSLHRPKST-PLSQPSANGVQTEGLDYDRLKQDILDEMRK 568
             +  +     Q   D    +S   P+ T   S  + +  +TE +    +  D+  E   
Sbjct: 691 GTTDEEDDDVEQEGAD----ESTSGPEDTRAASSLNLSNGETESVKTMIVHDDV--ESEP 744

Query: 569 ELTKLKEELIDAIRQELSKSNT 590
            +T  KE  +  +RQ  S S+T
Sbjct: 745 AMTPSKEGTL-IVRQTQSASST 765



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
           L +  ++R   E+  +    R +  ERQ R++ ++ +DR R++R E++  E  E    E 
Sbjct: 270 LVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETE-YEYSGSEE 328

Query: 246 ERQEQLERE 254
           E +E  E+E
Sbjct: 329 EEEEVPEQE 337


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 112/442 (25%), Positives = 181/442 (40%), Gaps = 79/442 (17%)

Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER 168
           E   S+E    +P Q  + P+ + N P +  L     +LQ++ +++    E L R+++ +
Sbjct: 322 EYSGSEEEEEEVPEQEGE-PSSIVNVPGESTLRRDFLRLQQENKERS---EALRRQQLLQ 377

Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
           E+  RE+ E +R    +L  E+ +R  Q++E++ RLE Q+R ER+ R  RQ+  ++ R+E
Sbjct: 378 EQQLREQEEYKR----QLLAERQKRIEQQKEQRRRLEEQQRREREAR--RQQEREQRRRE 431

Query: 229 RQERERLERLERERQERERQEQLEREQLEWERER---RISSAAAPASVETPLNSVLGDSS 285
           ++E+ RLE LER R+E E + + E E+   ERE+   R         +E     +L + +
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491

Query: 286 --------ASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337
                     E   QA     +   +Q  +L  L      P P    Q            
Sbjct: 492 MLLECRWREMEEHRQAERLQRQLQQEQAYLLS-LQHDHRRPHPQHSQQ------------ 538

Query: 338 PPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIA 397
           PPPP      P    P P  +  P                  A   ED    T  ++  A
Sbjct: 539 PPPPQQERSKPSFHAPEPKAHYEPAD---------------RAREVEDRFRKTNHSSPEA 583

Query: 398 GAKLRKVSRMEDTSFP------SGGNAIGVNSASSKTD---------TGRGNGPLPLGGS 442
            +K  +  R+ +   P      S GN+  V+ A  +               N   P+  S
Sbjct: 584 QSK--QTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRS 641

Query: 443 GLMEEMSALLARRRRIAE-----KGSTIETEQKEDKGEDSEPVTSKASSTSTPE--PTRK 495
               + S   A     ++       S + ++  + K E  +P T KA S S  +  P R 
Sbjct: 642 HSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDP-TQKAWSRSDSDEVPPRV 700

Query: 496 PWERTNTMNGSKSPVISRRDSP 517
           P   T     S+SPV+SRRDSP
Sbjct: 701 PVRTT-----SRSPVLSRRDSP 717



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 50/159 (31%), Positives = 85/159 (53%), Gaps = 27/159 (16%)

Query: 131 VQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERE---------------- 174
           +++ P++ ++ IQ +   ++ R+K  E++  E E    E  E E                
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348

Query: 175 ---------RLERERLER-ERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
                    RL++E  ER E L ++QL +E+Q RE QE  +RQ   ERQ+R+E+Q+   R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLRE-QEEYKRQLLAERQKRIEQQKEQRR 407

Query: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
             +E+Q RER  R ++ER++R R+++ +R   E ER R+
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 117/519 (22%), Positives = 199/519 (38%), Gaps = 78/519 (15%)

Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER------LERER----- 185
           Q+E E +RR+ +E++R +ELER R E E   R   E+ R+ERE+      LE E+     
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481

Query: 186 LEQEQLE----------RERQERERQERLERQERLERQERLERQERLDRERQERQERERL 235
           L+Q+ L+          RE +E  + ERL+RQ + E+   L  Q    R   +  ++   
Sbjct: 482 LQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPP 541

Query: 236 ERLERER------QERERQEQLEREQLEWERERRISSAAAPAS-------VETPLNS--- 279
            + ER +      + +   E  +R +   +R R+ + ++  A        +E P+ S   
Sbjct: 542 PQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSE 601

Query: 280 --VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAP--------PPPPPLPPGPAQASVA 329
               G+S +  P LQ  ++P    S    +   ++P         P P       ++   
Sbjct: 602 SFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDP 661

Query: 330 LPPPPGPPPPPPLPSTGPPPPPPPPPL----PNQVPPPPP---PPPAPPLPASGFFLASM 382
            PP           S    P P          ++VPP  P      +P L      L   
Sbjct: 662 CPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGS 721

Query: 383 SEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGS 442
            + N    G   + +  + R +    +   P  G+  G +S SS + +  G+ P    GS
Sbjct: 722 GQQNSQ-AGQRNSTSSIEPRLLWERVEKLVPRPGS--GSSSGSSNSGSQPGSHPGSQSGS 778

Query: 443 GLMEEMSALLARRRRIAEKGSTIETEQK--EDKGEDSEP--------VTSKASSTSTPEP 492
           G   E   + +  +        +E   K  EDK E   P        +T+ A      E 
Sbjct: 779 G---ERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVED 835

Query: 493 TRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKST-PLSQPSANGVQTE 551
            R P + T+  + S+    +  +     Q   D    +S   P+ T   S  + +  +TE
Sbjct: 836 VRPPHKVTDYSSSSEESGTTDEEDDDVEQEGAD----ESTSGPEDTRAASSLNLSNGETE 891

Query: 552 GLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNT 590
            +    +  D+  E    +T  KE  +  +RQ  S S+T
Sbjct: 892 SVKTMIVHDDV--ESEPAMTPSKEGTL-IVRQTQSASST 927



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 1/69 (1%)

Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
           L +  ++R   E+  +    R +  ERQ R++ ++ +DR R++R E++  E  E    E 
Sbjct: 270 LVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETE-YEYSGSEE 328

Query: 246 ERQEQLERE 254
           E +E  E+E
Sbjct: 329 EEEEVPEQE 337


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 48/136 (35%), Positives = 62/136 (45%), Gaps = 9/136 (6%)

Query: 243 QERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPS 302
           ++ +  +Q   E +E   +   S+    A    P+    G ++ + P + A + P   P 
Sbjct: 626 EKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPP- 684

Query: 303 QQGIVLGPLAPPPPPPLPPGPAQASVALPPP-PGPPPPPPLPSTGPPPPPPPPPLPNQVP 361
                  P  PP PPP PP P Q    +PPP P PPPPPP        PPPP P P  VP
Sbjct: 685 -------PGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVP 737

Query: 362 PPPPPPPAPPLPASGF 377
           PPP  PP PP P   F
Sbjct: 738 PPPILPPLPPFPPGLF 753



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 88/365 (24%), Positives = 143/365 (39%), Gaps = 62/365 (16%)

Query: 122  RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
            R+    P ++ +G  ++E E    + +  + ++E E E  E +  + +  +R+  E +  
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESEND-- 1077

Query: 182  ERERLEQEQLERERQERERQERLE----RQERLERQERLERQE-RLDRERQERQERERLE 236
            + +    E  E++  + + +E +     + E     E  E  E     E       +  E
Sbjct: 1078 DEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEE 1137

Query: 237  RLERERQERERQEQLEREQ---------LEWERERRISSAAAPA--------SVETPLNS 279
             + RE +E E +E++  E+          E + E    +  APA         V+    +
Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEA 1197

Query: 280  VLGDSSAS---EPGLQA-------ASQPAETP--SQQGIVLGPLAPPPP-------PPLP 320
            V  +   S   EP L         + +P E P  SQ+G +L  L+P PP       PPL 
Sbjct: 1198 VAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAML--LSPEPPAKEVEARPPLS 1255

Query: 321  PGPA---QASVALPPPPGPPPP--PPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
            P  A      V   PP   P P  PPLP   PP PP PPP P       P  P  PL   
Sbjct: 1256 PERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPL--- 1312

Query: 376  GFFLASMSEDNRPLT-GLAAAIAGAK-LRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRG 433
                   +ED+ P T GL  ++A ++    V        P  G + G++ +S +      
Sbjct: 1313 -------AEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPF 1365

Query: 434  NGPLP 438
            + P P
Sbjct: 1366 SYPAP 1370



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 43/116 (37%), Positives = 48/116 (41%), Gaps = 19/116 (16%)

Query: 269  APASVETPLNSVLGDSSAS--EPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQA 326
            A A   TPL  +L    AS   P  +   +P  +P     + GPL  PP        A  
Sbjct: 1449 AQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPP------AGAAL 1502

Query: 327  SVALPPPPGPPPPPPLPSTGPPP-----------PPPPPPLPNQVPPPPPPPPAPP 371
               L   PG P  P  PST  P            P PPPPLP Q PPPPPPPP  P
Sbjct: 1503 GRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEP 1558



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 41/143 (28%), Positives = 51/143 (35%), Gaps = 29/143 (20%)

Query: 265 SSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPA 324
           ++AA   S + P  +V G   +S P  +A  Q + T +           PPP    P P 
Sbjct: 342 ATAAFRGSSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHT---------PPPAQATPAPG 392

Query: 325 QASVALP---PPPGPPPPPPLPSTGP-------------PPPPPPPPLPNQVPPPPPPPP 368
             S   P   P    PPPP  P+                P PPP PP        P  PP
Sbjct: 393 FKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPP 452

Query: 369 APPLPASGFFLASMSEDNRPLTG 391
            PP P +     SM    RP  G
Sbjct: 453 GPPPPDTN----SMELGGRPTFG 471



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/95 (32%), Positives = 33/95 (34%), Gaps = 41/95 (43%)

Query: 313  PPPPPPLPPGPAQASVALPPPPGPPP--PPPLP--------------------------- 343
            P PPPPLPP P       PPPP PPP  P  LP                           
Sbjct: 1537 PAPPPPLPPQP-------PPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEY 1589

Query: 344  -----STGPPPPPPPPPLPNQVPPPPPPPPAPPLP 373
                 S GP   PP     + VPP   P  +PP P
Sbjct: 1590 MELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQP 1624



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/214 (24%), Positives = 69/214 (32%), Gaps = 82/214 (38%)

Query: 234 RLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQA 293
           R+E L +E  +R +   L     + E +   S  ++ +S  +PL       + S+PG + 
Sbjct: 502 RIEMLLKE--QRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPF---GTNSQPGFRG 556

Query: 294 ASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVAL------PPPPGPPPP-------- 339
            + P+  PS  G     L    P PLP       + L      PP PGPP P        
Sbjct: 557 PTPPSSRPSSTG-----LEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTA 611

Query: 340 -----------------------------------PPLPSTGPPPPPP------------ 352
                                              P  P T    P P            
Sbjct: 612 EVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAA 671

Query: 353 ----PPPLPNQVPPPP-----PPPPAPPLPASGF 377
                P LP  +PPPP     PPPP PP P  GF
Sbjct: 672 PSVLAPTLP--LPPPPGFPPLPPPPPPPPPQPGF 703



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 23/64 (35%), Positives = 25/64 (39%), Gaps = 7/64 (10%)

Query: 314 PPPPPLPPGPAQASVALPPPPGPPPPPP-------LPSTGPPPPPPPPPLPNQVPPPPPP 366
           P PPPLPP    A      PPGPPPP          P+ G  P P   P    +   P  
Sbjct: 432 PAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAG 491

Query: 367 PPAP 370
           P  P
Sbjct: 492 PEKP 495



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 23/56 (41%), Positives = 25/56 (44%), Gaps = 4/56 (7%)

Query: 310  PLAPPPPPPLP---PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPP 362
            PL  P P PLP   P   +A    P P  P  P PL S  PPP    P  P + PP
Sbjct: 1430 PLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASC-PPPMKRKPGRPRRSPP 1484



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 32/103 (31%), Positives = 42/103 (40%), Gaps = 12/103 (11%)

Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS----- 327
           ++  ++ VLG      P     S   +T     ++ G  A P PP +    A AS     
Sbjct: 756 MQVDMSHVLGGQWGGMP----MSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQF 811

Query: 328 VALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAP 370
           V LPP  GP     L ++GP      PPLP   P  PPP   P
Sbjct: 812 VNLPPYRGPFS---LSNSGPGRGQHWPPLPKFDPSVPPPGYMP 851



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 43/134 (32%), Positives = 50/134 (37%), Gaps = 26/134 (19%)

Query: 265  SSAAAPASV--ETPLNSVLGDSSASEPGLQAA--SQPAETPSQQGIVLGPLAP------P 314
            S+   PA+   E PL+      S S P +  +  S PA +PS     L P  P       
Sbjct: 1332 STETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGL-PRTPGRDFSFT 1390

Query: 315  PPPPLPPGPAQASVALPPP------PGPPPPPPLPSTGPPPPPPPP-PLPNQVPP----- 362
            P    P GP    V   P        GP   P L  TG P P P P PLP  +P      
Sbjct: 1391 PTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQ 1450

Query: 363  ---PPPPPPAPPLP 373
               P P PP  P P
Sbjct: 1451 ARAPTPLPPLLPAP 1464



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 31/115 (26%), Positives = 41/115 (35%), Gaps = 13/115 (11%)

Query: 269  APASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPP--------PPLP 320
            +P S   P  S+        PG   +  P  +    G +L P+ P P         P   
Sbjct: 1363 SPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFS-EPSGPLLLPVCPLPTGRRDERSGPLAS 1421

Query: 321  PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPP----PPPPPAPP 371
            P   +  + LP P   P P  LP+        P PLP  +P P    PPP    P
Sbjct: 1422 PVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKP 1476



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 28/87 (32%), Positives = 34/87 (39%), Gaps = 14/87 (16%)

Query: 261  ERRISSAAAPASVETPLNSVLGDSSASEPGL---QAASQPAETPSQQGIVLGPLAPPPPP 317
            E   + A+ P+    PL     D     PGL    A SQ  ET         P  P   P
Sbjct: 1296 EPETTDASHPSVPPEPLAE---DHPPHTPGLCGSLAKSQSTETV--------PATPGGEP 1344

Query: 318  PLPPGPAQASVALPPPPGPPPPPPLPS 344
            PL  G +  S++ P  PG P   P PS
Sbjct: 1345 PLSGGSSGLSLSSPQVPGSPFSYPAPS 1371


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,958,170
Number of Sequences: 37866
Number of extensions: 2705962
Number of successful extensions: 189434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2916
Number of HSP's successfully gapped in prelim test: 2106
Number of HSP's that attempted gapping in prelim test: 25163
Number of HSP's gapped (non-prelim): 50406
length of query: 591
length of database: 18,247,518
effective HSP length: 108
effective length of query: 483
effective length of database: 14,157,990
effective search space: 6838309170
effective search space used: 6838309170
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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