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Search of human proteins with 56549694
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56549694 enabled homolog isoform a [Homo sapiens]
(591 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56549694 enabled homolog isoform a [Homo sapiens] 1181 0.0
gi|39930375 enabled homolog isoform b [Homo sapiens] 1126 0.0
gi|7706687 Enah/Vasp-like [Homo sapiens] 210 3e-54
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens] 170 4e-42
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 104 3e-22
gi|33356148 formin-like 1 [Homo sapiens] 99 1e-20
gi|148746195 trichohyalin [Homo sapiens] 98 2e-20
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 98 2e-20
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 94 3e-19
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 94 3e-19
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 94 4e-19
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 94 4e-19
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 94 5e-19
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 94 5e-19
gi|18426913 drebrin 1 isoform b [Homo sapiens] 93 6e-19
gi|18426915 drebrin 1 isoform a [Homo sapiens] 93 6e-19
gi|52485606 formin-like 2 [Homo sapiens] 92 1e-18
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 92 1e-18
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 92 1e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 90 7e-18
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 90 7e-18
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 89 9e-18
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 89 1e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 88 2e-17
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 87 3e-17
gi|160707881 formin 2 [Homo sapiens] 87 3e-17
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 87 6e-17
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 86 7e-17
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 86 7e-17
gi|210032580 SET domain containing 1B [Homo sapiens] 86 7e-17
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 1181 bits (3056), Expect = 0.0
Identities = 591/591 (100%), Positives = 591/591 (100%)
Query: 1 MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI
Sbjct: 1 MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
Query: 61 NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL
Sbjct: 61 NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER
Sbjct: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER
Sbjct: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
Query: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET
Sbjct: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
Query: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV
Sbjct: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
Query: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG
Sbjct: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
Query: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV
Sbjct: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
Query: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540
TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL
Sbjct: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540
Query: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591
SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA
Sbjct: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 1126 bits (2912), Expect = 0.0
Identities = 570/591 (96%), Positives = 570/591 (96%), Gaps = 21/591 (3%)
Query: 1 MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI
Sbjct: 1 MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
Query: 61 NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL
Sbjct: 61 NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER
Sbjct: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER
Sbjct: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
Query: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET
Sbjct: 241 ERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAET 300
Query: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV
Sbjct: 301 PSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV 360
Query: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG
Sbjct: 361 PPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIG 420
Query: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV
Sbjct: 421 VNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPV 480
Query: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPL 540
TSKASSTSTPEPTRKPWERTNTMNGSKSPVIS RPKSTPL
Sbjct: 481 TSKASSTSTPEPTRKPWERTNTMNGSKSPVIS---------------------RPKSTPL 519
Query: 541 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 591
SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA
Sbjct: 520 SQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA 570
>gi|7706687 Enah/Vasp-like [Homo sapiens]
Length = 418
Score = 210 bits (535), Expect = 3e-54
Identities = 108/161 (67%), Positives = 128/161 (79%), Gaps = 11/161 (6%)
Query: 2 SEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVI 60
SEQSICQARA+VMVYDD +KKWVP G GFSR++IYH+T +NTFRVVG K+QD QVVI
Sbjct: 4 SEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63
Query: 61 NCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTL 120
N +I KGLKYNQAT TFHQWRDARQVYGLNF SKE+A F++AM+ AL ++NSQE GP+
Sbjct: 64 NYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSS 123
Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQE---QQRQKELER 158
R QVQNGPS +E++IQRRQ+ E QQRQ+ LER
Sbjct: 124 QR-------QVQNGPSPDEMDIQRRQVMEQHQQQRQESLER 157
Score = 179 bits (454), Expect = 6e-45
Identities = 122/285 (42%), Positives = 162/285 (56%), Gaps = 42/285 (14%)
Query: 317 PPLPPG-PAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP---PPPAPPL 372
P LPPG P+ A+ A P+ +GPPPPPPPP VPPPP PPP PPL
Sbjct: 164 PILPPGHPSSAASA-----------PVSCSGPPPPPPPP-----VPPPPTGATPPPPPPL 207
Query: 373 PASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGR 432
PA G S D ++GLAAAIAGAKLR+V R ED SGG++ S +SK+D R
Sbjct: 208 PAGG--AQGSSHDESSMSGLAAAIAGAKLRRVQRPEDA---SGGSS---PSGTSKSDANR 259
Query: 433 GNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASST----- 487
+ GG GLMEEM+ LLA+RR+ A + S E+KED+ + +P TS + T
Sbjct: 260 ASS--GGGGGGLMEEMNKLLAKRRKAASQ-SDKPAEKKEDESQMEDPSTSPSPGTRAASQ 316
Query: 488 --STPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSA 545
++ E RKPWER+N++ S ++SR S K+ +P S S
Sbjct: 317 PPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKS----PEAKSPLQSQPHSRMKPAGSV 372
Query: 546 NGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNT 590
N + + D DR+KQ+IL+E+ +EL K+KEE+IDAIRQELS +T
Sbjct: 373 NDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGIST 417
Score = 33.5 bits (75), Expect = 0.56
Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 16/118 (13%)
Query: 210 LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAA 269
+ QE +R + E + R E+ +++RQE LER +SA
Sbjct: 114 MNSQEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERR----------TSATG 163
Query: 270 PASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS 327
P L S+AS P + P P G PPPPPLP G AQ S
Sbjct: 164 PI-----LPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATP-PPPPPLPAGGAQGS 215
>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
Length = 380
Score = 170 bits (430), Expect = 4e-42
Identities = 94/149 (63%), Positives = 108/149 (72%), Gaps = 8/149 (5%)
Query: 1 MSEQSICQARAAVMVYDDANKKWVPAG-GSTGFSRVHIYHHTGNNTFRVVGRKIQ-DHQV 58
MSE IC +RA VM+YDD NK+W+PAG G FSRV IYH+ N+FRVVGRK+Q D QV
Sbjct: 1 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQV 60
Query: 59 VINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGP 118
VINCAI +G+KYNQAT FHQWRDARQV+GLNFGSKEDA FA+ M ALE L + GP
Sbjct: 61 VINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEAL--EGGGP 118
Query: 119 TLPRQNSQLPA-QVQNGPSQEELEIQRRQ 146
P LP V NGPS EE+E Q+RQ
Sbjct: 119 PPP---PALPTWSVPNGPSPEEVEQQKRQ 144
Score = 149 bits (375), Expect = 9e-36
Identities = 112/308 (36%), Positives = 147/308 (47%), Gaps = 82/308 (26%)
Query: 313 PPPPPPLP-------PGPAQASVALPPPPGPPP-----------PPPLPSTGPPPPPPPP 354
PPPPP LP P P + PGP PP P+ GPPPPP PP
Sbjct: 118 PPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPP 177
Query: 355 PLPNQVPPP--PP-------------PPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGA 399
P P PPP PP PPPAPPLPA+ GLAAAIAGA
Sbjct: 178 PPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAA----QGPGGGGAGAPGLAAAIAGA 233
Query: 400 KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIA 459
KLRKVS+ E+ SGG + K ++GR GG GLMEEM+A+LARRR+
Sbjct: 234 KLRKVSKQEEA---SGG------PTAPKAESGRS------GGGGLMEEMNAMLARRRKAT 278
Query: 460 EKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRK 519
+ G E K++ EP +A + E R+PWE+ +T PR
Sbjct: 279 QVG---EKTPKDESANQEEP---EARVPAQSESVRRPWEKNST------------TLPRM 320
Query: 520 NQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELID 579
+S S+ ++ P + S ++ D R+KQ++L+E++KEL K+KEE+I+
Sbjct: 321 -------KSSSSVTTSETQPCTPSS-----SDYSDLQRVKQELLEEVKKELQKVKEEIIE 368
Query: 580 AIRQELSK 587
A QEL K
Sbjct: 369 AFVQELRK 376
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 104 bits (259), Expect = 3e-22
Identities = 72/194 (37%), Positives = 93/194 (47%), Gaps = 28/194 (14%)
Query: 312 APPPPP-------PLPPGPAQASVALPPPPG----PPPPPPLPSTGPPPPPPPPPLPNQV 360
APPPPP P PP P++ SVA+PPPP PPPPP LPS+ P PPPPPP V
Sbjct: 309 APPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGV 368
Query: 361 ----PPPPPPPPAPPLPASGFFLASMSEDNRPLT-GLAAAI-----AGAKLRKVSRMEDT 410
PPPPPPPP PP P L S + P T G AA+ GA+L+KV +
Sbjct: 369 GPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRP 428
Query: 411 SFPSGGNAI------GVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGST 464
SG +A+ G+ S D P P SG++ + ++ +R +
Sbjct: 429 VSCSGRDALLDQIRQGI-QLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDE 487
Query: 465 IETEQKEDKGEDSE 478
E E E+ ED +
Sbjct: 488 DEDEDDEEDFEDDD 501
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 98.6 bits (244), Expect = 1e-20
Identities = 82/235 (34%), Positives = 97/235 (41%), Gaps = 63/235 (26%)
Query: 189 EQLERERQERERQERLERQ-----ERLERQERLERQERLDRERQERQERERLERLERERQ 243
E E + E E L+ Q ERL E + + E+Q Q R+ LE L
Sbjct: 389 EDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFS 448
Query: 244 E----------------------RERQEQLEREQLEWERERRI--------SSAAAPASV 273
E R +L+ E+LE + RI S P +V
Sbjct: 449 ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAV 508
Query: 274 ETPLNSVLGDSSASEPGLQAASQ-----PAETPSQQGIVLGPLAPPPPPPLP--PGPAQA 326
TP GD A PG+ S PA P+ APPPPPPLP P P +A
Sbjct: 509 ATPSG---GD--APTPGVPTGSPSPDLAPAAEPAPGA------APPPPPPLPGLPSPQEA 557
Query: 327 SVALPPP-------PGPPPPPPLPSTGPPPPPPPPPLP---NQVPPPPPPPPAPP 371
+ PP P PPP PPLP PPPPPPPPP P VPPPPPPPP PP
Sbjct: 558 PPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPP 612
Score = 52.8 bits (125), Expect = 9e-07
Identities = 27/60 (45%), Positives = 31/60 (51%), Gaps = 9/60 (15%)
Query: 289 PGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPP 348
P L + +P P G + P PPPPPP GP +PPPP PPPPPP GPP
Sbjct: 566 PPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGP------VPPPPPPPPPPP---GGPP 616
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 98.2 bits (243), Expect = 2e-20
Identities = 56/131 (42%), Positives = 96/131 (73%), Gaps = 5/131 (3%)
Query: 137 QEELEIQRRQLQEQQRQ-KELERERLERERMERERLERERLERERLERERLEQEQLERER 195
QEE ++R+LQE++ Q ++LER+ L RER E E+ +++RL RE+ R + E+E+ E++
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEERREQQE 319
Query: 196 QERERQERLERQ-ERLERQERLERQERLDRE-RQERQERERLERLERERQERERQEQLER 253
+ RE+QER E+Q ER E+Q R E++ER +++ R+E++E R ++L RE++E R++QL R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 254 EQLEWERERRI 264
EQ + RE+++
Sbjct: 380 EQ-QLRREQQL 389
Score = 97.1 bits (240), Expect = 4e-20
Identities = 53/125 (42%), Positives = 87/125 (69%), Gaps = 4/125 (3%)
Query: 141 EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERER 200
E ++ Q +E QRQ+EL+ E + ++ER+ L RER E E+ +++RL +EQ R +QE ER
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEER 314
Query: 201 QERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERERQEQLEREQLEWE 259
+E +++ER E+QER E+QE R +++ + QE R ++L RE++E R++QL REQ E
Sbjct: 315 RE--QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 260 RERRI 264
RE+++
Sbjct: 373 REQQL 377
Score = 92.8 bits (229), Expect = 8e-19
Identities = 59/143 (41%), Positives = 96/143 (67%), Gaps = 16/143 (11%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERE---RMERERLERERLERERLERE------RLE 187
+EE + QRR+ Q++ Q+E E+E +RE R E E+L+ E +R+R +E +LE
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 188 QEQLERERQERE-RQERLERQERLERQERLERQE-----RLDRERQERQERERLERLERE 241
+++L RERQE E +Q+RL R+++L R++ ER+E R +ER+E+QE R ++L RE
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 242 RQERERQEQLEREQLEWERERRI 264
++ER R++QL REQ E RE+++
Sbjct: 343 QEER-REQQLRREQEEERREQQL 364
Score = 92.4 bits (228), Expect = 1e-18
Identities = 52/146 (35%), Positives = 95/146 (65%), Gaps = 7/146 (4%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
+Q +L + Q QEE +RR+ QE++R+++ RE+ E R ++ R E+E ++L
Sbjct: 295 QQQQRLRREQQLRRKQEE---ERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 182 ERERLEQ---EQLERERQERERQERLERQERLERQERLERQERLDRERQERQERE-RLER 237
RE+ E+ +QL RE++E R+++L R+++L R+++L R+++L RE+Q R+E++ R E+
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 238 LERERQERERQEQLEREQLEWERERR 263
R Q+ R++QL REQ E E++
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQK 437
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/154 (38%), Positives = 97/154 (62%), Gaps = 15/154 (9%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE------RLERERMER--ERLER 173
R+ L + + QE E + ++ QE++R + L+RE RL+RE+ ER +RL+R
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 174 ERLERERLERERLEQEQLERERQERERQERL----ERQERLERQERLERQERLDRERQER 229
E E ERLE+E +++L+RE E ER+++L E++ER ++Q R E+QER ++ +
Sbjct: 605 E--EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 230 QERERLE-RLERERQERERQEQLEREQLEWERER 262
+E ERLE RL+RE +E R+++L E+ E RER
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Score = 89.4 bits (220), Expect = 9e-18
Identities = 56/134 (41%), Positives = 89/134 (66%), Gaps = 7/134 (5%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+E LE++R+ +E+Q+Q+ ++R+ +E E+E +RE + R+ E+ + E+ Q +RE Q
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 197 ERERQ-ERLERQE-RLERQERLERQERLDRERQ--ERQERERLERLERERQERERQEQLE 252
E E Q +LERQE R ERQE ++Q+RL RE+Q +QE ER E+ E R+++ER+EQ E
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 253 ---REQLEWERERR 263
+QL E+E R
Sbjct: 333 ERREQQLRREQEER 346
Score = 89.0 bits (219), Expect = 1e-17
Identities = 67/196 (34%), Positives = 107/196 (54%), Gaps = 19/196 (9%)
Query: 79 QWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
+WR V KE+ + E+ +E L RQ + Q + Q
Sbjct: 245 EWRKRETVL-----RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299
Query: 139 ---ELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE----RLEQEQL 191
E +++R+Q +E++ Q+E RE+ ER + ER E++ L RE+ ER R EQE+
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ-LRREQEERREQQLRREQEEE 358
Query: 192 ERERQERERQERLERQERLERQERLERQERLDRERQERQERE--RLERLERERQERERQE 249
RE+Q R QE R+++L R+++L R+++L RE+Q R+E++ R ++L RE+Q R R++
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQ 417
Query: 250 QLEREQ---LEWERER 262
QL REQ E E ER
Sbjct: 418 QLRREQQLRREQEEER 433
Score = 88.2 bits (217), Expect = 2e-17
Identities = 54/146 (36%), Positives = 97/146 (66%), Gaps = 7/146 (4%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER--ERLERERLERE 179
R+ QL + Q +E+ E +R Q + +++Q+E ++L RE+ ER ++L RE+ E
Sbjct: 301 RREQQLRRK-QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERE--RLER 237
R ++ R EQE+ ER Q+ R+++L R+++L R+++L R+++L RE+Q R+E++ R ++
Sbjct: 360 REQQLRREQEE-ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 238 LERERQERERQEQLEREQLEWERERR 263
L RE+Q R QE+ ER + + E+ERR
Sbjct: 419 LRREQQLRREQEE-ERHEQKHEQERR 443
Score = 88.2 bits (217), Expect = 2e-17
Identities = 57/139 (41%), Positives = 91/139 (65%), Gaps = 13/139 (9%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLER-ERMERERLERERLERERLERERLE-------- 187
+EE +Q+R EQQ ++E E R + +R E +RLE+ER E +RL+RE+ E
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKR 581
Query: 188 QEQLERERQERERQERLERQERLERQERLERQERLDR--ERQERQERERLERLERERQER 245
+E+ ++R +RE++ERLE++ + E ERLE++ER ++ +R+E +E R + L+ E QE
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 246 ERQEQLEREQLEWERERRI 264
RQ+QL REQ E RE+R+
Sbjct: 642 RRQQQLRREQQE-RREQRL 659
Score = 87.8 bits (216), Expect = 3e-17
Identities = 53/146 (36%), Positives = 93/146 (63%), Gaps = 5/146 (3%)
Query: 121 PRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER 180
P++ +L + + E E++R + +E+Q+Q+ L RE+ R + E ER RE+ E R
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERR 322
Query: 181 LERERLEQEQLERERQ-ERERQERLERQERLER-QERLERQERLDRERQERQERERLERL 238
++ER EQ++ RE+Q RE++ER E+Q R E+ +ER E+Q R ++E + R+++ R E+
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 239 ERERQERERQEQLEREQLEWERERRI 264
R Q+ R++QL REQ + RE+++
Sbjct: 383 LRREQQLRREQQLRREQ-QLRREQQL 407
Score = 87.0 bits (214), Expect = 4e-17
Identities = 50/142 (35%), Positives = 94/142 (66%), Gaps = 4/142 (2%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
+Q + Q + +E E Q R+ QE++R+++L RE+ E ER E++ L RE+ E ER
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQ-EEERREQQ-LRREQ-EEERR 373
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
E++ ++QL RE+Q R R+++L R+++L R+++L R+++L RE+Q R+E++ E E
Sbjct: 374 EQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 242 RQERERQEQLEREQLEWERERR 263
R E++ +++ ++L+ E+E R
Sbjct: 433 RHEQKHEQERREQRLKREQEER 454
Score = 85.9 bits (211), Expect = 1e-16
Identities = 57/153 (37%), Positives = 96/153 (62%), Gaps = 11/153 (7%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERE-RLERERLER 178
L R+ + Q+ ++ LE +RR+ + ++ Q+E + L+RE R+ RL+RE+ ER
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 179 --ERLERE---RLEQEQLERERQERERQERLERQERLERQERLER-QERLDRERQERQER 232
+RL+RE RLEQE+ +R +RE E RQ+ L+ +E+ ER Q++L RE+QER+E
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE- 656
Query: 233 ERLERLERERQERERQEQLEREQLEWERERRIS 265
+RL+RE +E +++L+RE E RE+ ++
Sbjct: 657 ---QRLKREEEEERLEQRLKREHEEERREQELA 686
Score = 85.9 bits (211), Expect = 1e-16
Identities = 57/135 (42%), Positives = 86/135 (63%), Gaps = 11/135 (8%)
Query: 137 QEELEIQRRQLQEQQ--RQKELERERLERERMERERLERERLERERLERERLEQE--QLE 192
+EE E +RRQ +E+Q ++EL++E + R ERE+ R+ LER+ E E ++QE QL
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 193 RERQERERQERLERQERLERQERLERQERLDRERQE--RQERERLERLERERQERERQEQ 250
RE E+ R++ LERQ R E +E + +E+L RE QE RQERER R E E Q ++R+++
Sbjct: 1155 REEPEKRRRQELERQYR-EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 251 L----EREQLEWERE 261
+R L+W+ E
Sbjct: 1214 YRDEDQRSDLKWQWE 1228
Score = 84.7 bits (208), Expect = 2e-16
Identities = 58/159 (36%), Positives = 93/159 (58%), Gaps = 18/159 (11%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQL----QEQQRQKELERERLERERMERER---LERE 174
R+ +L + + +EEL+ + QL +E +R++ELER+ + E +++E L E
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 175 RLERERLERER---------LEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225
+R R ERER E+EQL RE +E+ R++ LERQ R E +E + +E+L RE
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR-EEEEVQQEEEQLLRE 1156
Query: 226 RQERQERERLERLERERQE-RERQEQLEREQLEWERERR 263
E++ R+ LER RE +E ++ +EQL RE+ E R+ R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Score = 84.3 bits (207), Expect = 3e-16
Identities = 52/136 (38%), Positives = 90/136 (66%), Gaps = 10/136 (7%)
Query: 137 QEELEIQRRQLQEQQRQKELER----ERLERERMERERLERERLERERLERERLEQEQLE 192
QE E Q R+ QE++R++ L+R ERL++ ++L RE+ ER +R E+++LE
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 193 RERQE---RERQERLERQERLERQERLERQERLDRERQER-QERERLERLERERQERERQ 248
+ER+E + QE ER+++L ++E RQ+RL RE++ER ++R + E +ER QE R+
Sbjct: 560 QERREQRLKREQE--ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 249 EQLEREQLEWERERRI 264
++L+RE+ E ER +++
Sbjct: 618 QRLKREEPEEERRQQL 633
Score = 83.6 bits (205), Expect = 5e-16
Identities = 46/158 (29%), Positives = 92/158 (58%), Gaps = 17/158 (10%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
+Q + Q++ + + RR+ +E++R+++L RE+ E R ++ R E++ ++L
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 182 ERE-RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
RE +L +EQ R Q+ R+++L R+++L R+++L R++ +R Q+ ++ R +RL+R
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Query: 241 ERQER----------------ERQEQLEREQLEWERER 262
E++ER R++QL+R+Q E RER
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Score = 83.6 bits (205), Expect = 5e-16
Identities = 57/158 (36%), Positives = 88/158 (55%), Gaps = 14/158 (8%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE--LERERLERERMERERLERERLE 177
L ++ QL + + ++ELE Q R+ +E Q+++E L E +R R ERER RE E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 178 RERLERERLEQEQLERERQERERQERLERQERLE------------RQERLERQERLDRE 225
++ E + L +E+ +R RQE ERQ R E + + E R++ LERQ R + E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 226 RQERQERERLERLERERQERERQEQLEREQLEWERERR 263
Q+ +E+ E E+ RQERERQ + E E +R++R
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Score = 83.2 bits (204), Expect = 6e-16
Identities = 63/165 (38%), Positives = 93/165 (56%), Gaps = 26/165 (15%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE----------LERERLERERMERERL 171
R+ QL + + +EE E +RRQ QE+Q ++E L ER +R R ERER
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 172 ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE--- 228
R+ + ++ E + L +E +R RQERE++ R E +E + +E+L R+ER R RQE
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR-EEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 229 --------RQERERLERLERER---QERERQEQLEREQLEWERER 262
+QE E+L R ERE+ QERERQ + E E+L+ E E+
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYR-EEEELQQEEEQ 1062
Score = 82.8 bits (203), Expect = 8e-16
Identities = 52/143 (36%), Positives = 85/143 (59%), Gaps = 6/143 (4%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ QL + Q Q+ Q + EQ+ ++E +RL+RE+ ER R+ L+RE
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER----RDWLKREE- 462
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
E ER EQE+ +++ + + +ER ER +LE +ER E+QER +++ + QE R +RL+R+
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 242 RQERERQEQLERE-QLEWERERR 263
+E Q++L E QL E+E R
Sbjct: 523 EEEERLQQRLRSEQQLRREQEER 545
Score = 82.4 bits (202), Expect = 1e-15
Identities = 48/128 (37%), Positives = 86/128 (67%), Gaps = 3/128 (2%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
QE+L +++ LQE++ + + E ER +R R E+ER RE + ++ E + L +E+ +R RQ
Sbjct: 896 QEQLRKEQQLLQEEEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERER-LERLERERQERERQEQLEREQ 255
ERERQ R +++ + +++E+L +E R RQER+++ R E L++E ++ R+E+ +R +
Sbjct: 955 ERERQYRKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 256 LEWERERR 263
EWER+ R
Sbjct: 1014 QEWERQYR 1021
Score = 82.4 bits (202), Expect = 1e-15
Identities = 59/154 (38%), Positives = 97/154 (62%), Gaps = 20/154 (12%)
Query: 123 QNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER--ERLERER 180
+ Q A+ ++ SQEE ++ R + +E++R++E +R+ E E++ +ER E+ R ER+R
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 181 LERER-----------LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
RE LE+EQ R RQERER + L+ +++L QER E+Q R DR+R+ R
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLR-RQERER-KFLKEEQQLRCQER-EQQLRQDRDRKFR 1417
Query: 230 QERERLERLERERQERERQEQLEREQLEWERERR 263
+E ++L R ER+R+ RE ++Q+ R+ ERER+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQ----ERERK 1447
Score = 82.4 bits (202), Expect = 1e-15
Identities = 53/157 (33%), Positives = 94/157 (59%), Gaps = 7/157 (4%)
Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER 168
++L ++ P R+ QL Q ++ +EE ++++ + ++Q R +E +R+ E E++ +
Sbjct: 1748 KILEEEQLRPE--REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
ER E++ ++R + R E+EQL+ E QE+ ++ +RQ R E E+ QE+ RE QE
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE--EQFATQEKSRREEQE 1863
Query: 229 R-QERERLERLERERQERERQEQLEREQLEWERERRI 264
QE E+ R ERER+ RE E + R+Q E +R R++
Sbjct: 1864 LWQEEEQKRRQERERKLRE--EHIRRQQKEEQRHRQV 1898
Score = 82.0 bits (201), Expect = 1e-15
Identities = 53/154 (34%), Positives = 94/154 (61%), Gaps = 15/154 (9%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ QL + + L+++ + +EQQ ++E + R + ER E +RL+R+ E ERL
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE-QRLKRQE-EEERL 528
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER-------QERER 234
++ ++QL RE++ER +E+L ++E +R E+ R++RL RE++ER +E R
Sbjct: 529 QQRLRSEQQLRREQEER--REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586
Query: 235 LERLERERQERERQ----EQLEREQLEWERERRI 264
+RL+RE++ER Q E++ER + E RE+R+
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Score = 81.6 bits (200), Expect = 2e-15
Identities = 68/175 (38%), Positives = 104/175 (59%), Gaps = 35/175 (20%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER----------ERMERERL 171
R+ QL + Q QEE E ++ ++++R++ L+RE+ ER ER E+ER
Sbjct: 414 RREQQLRREQQLRREQEE-ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 172 --------ERERLER-------ERLERERLEQEQLERERQERERQERLERQERLER-QER 215
E ER ER ER E++ ++QL RE++ER R++RL+RQE ER Q+R
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER-REQRLKRQEEEERLQQR 531
Query: 216 LERQERLDRERQERQE----RERLERLERERQE-RERQEQLER--EQLEWERERR 263
L +++L RE++ER+E RE +RLE+ER+E R ++EQ ER + L+ E ERR
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586
Score = 80.9 bits (198), Expect = 3e-15
Identities = 52/131 (39%), Positives = 80/131 (61%), Gaps = 8/131 (6%)
Query: 141 EIQRRQLQEQQRQKELERERLERERM----ERERLERERLERERLERERLEQE--QLERE 194
E ++R+LQE++RQ E E + E ERE R+ LER+ + E L+QE QL RE
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 195 RQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQE-RERQEQLER 253
E+ R++ ERQ R E +E + +E+L RE +E++ R+ LER RE +E ++ +EQL R
Sbjct: 1097 EPEKRRRQERERQCR-EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 254 EQLEWERERRI 264
E+ E R + +
Sbjct: 1156 EEPEKRRRQEL 1166
Score = 80.5 bits (197), Expect = 4e-15
Identities = 55/162 (33%), Positives = 95/162 (58%), Gaps = 10/162 (6%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
L SQE + QL Q + +E + RRQ + QQR+++ +R+ E E++ +ER
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 171 LERERLERERLERERLEQEQLERERQER---ERQERLERQERLE--RQERLERQERLDRE 225
E++ +ER + RLE++++ R+ QER E +++L RQE + RQER +R+ R D +
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER-DRKFREDEQ 1626
Query: 226 RQERQERERLERLERERQERERQEQLER----EQLEWERERR 263
+ +E ++L R ER+R+ E + QL R +QL +R+R+
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668
Score = 80.5 bits (197), Expect = 4e-15
Identities = 54/155 (34%), Positives = 90/155 (58%), Gaps = 5/155 (3%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPS-QEELEIQRRQLQEQQRQKELERERLERERMERE 169
L QE + QL Q + QEE +++R++L+ + R++E R+ E+E++ R+
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 170 RLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE-RQE 228
R+ LE E+L ER E++QL RQER+R+ R E Q R ER+E+ R + DR+ R+E
Sbjct: 1744 ERYRKILEEEQLRPER-EEQQLR--RQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800
Query: 229 RQERERLERLERERQERERQEQLEREQLEWERERR 263
Q R+ E + Q+R+ + + E EQL+ E + +
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Score = 79.7 bits (195), Expect = 7e-15
Identities = 55/149 (36%), Positives = 86/149 (57%), Gaps = 9/149 (6%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKE--LERERLERERMERERLERERLE 177
L ++ QL + + ++E E Q R+ E Q+++E L ER +R ERER RE E
Sbjct: 996 LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE 1055
Query: 178 RERLERERLEQEQLERERQERERQ----ERLERQERLERQERLERQERLDRERQERQERE 233
++ E + L +E+ R RQE ERQ E L+++E +E E++ R +RERQ R+E E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 234 ---RLERLERERQERERQEQLEREQLEWE 259
E+L RE +E+ R+++LER+ E E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEE 1144
Score = 79.3 bits (194), Expect = 9e-15
Identities = 52/127 (40%), Positives = 81/127 (63%), Gaps = 8/127 (6%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLE-RERLERERLEQEQLERERQ 196
+E +++RR+L E +R+ E+++ RER +R E E E R+R R E+E+L+ E
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
+R+R E QE E+ +LERQE L RERQE ++++ +RL RE+Q R +QE+ REQ
Sbjct: 266 QRQR----ELQEEEEQLRKLERQE-LRRERQEEEQQQ--QRLRREQQLRRKQEEERREQQ 318
Query: 257 EWERERR 263
E RE++
Sbjct: 319 EERREQQ 325
Score = 79.3 bits (194), Expect = 9e-15
Identities = 60/163 (36%), Positives = 94/163 (57%), Gaps = 11/163 (6%)
Query: 122 RQNSQLPAQVQNGPSQE-ELEIQRRQLQEQQRQKELERER-LERERMERERLERERLERE 179
R+ QL + Q Q+ E Q R+ Q+ +R+++L RE+ L RE+ R E ER E++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERER---LE 236
E+ER EQ +R++ ER++ L+R+E ER E+ R+++L R+ QE + RER LE
Sbjct: 438 H-EQERREQRL---KREQEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLE 492
Query: 237 RLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNS 279
ER Q+ R++QL REQ E RE+R+ ++ L S
Sbjct: 493 EEERREQQERREQQLRREQ-EERREQRLKRQEEEERLQQRLRS 534
Score = 79.0 bits (193), Expect = 1e-14
Identities = 55/142 (38%), Positives = 81/142 (57%), Gaps = 18/142 (12%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+EEL+ + QL ++R+K R R E ER R++ E ++ E + L ER ++ ERERQ
Sbjct: 993 EEELQQEEEQLLREEREK---RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 197 ERERQERLERQERL-------ERQERLERQERLDRERQE------RQERERLERLERERQ 243
RE +E + +E+L R++ LERQ R + E Q+ R+E E+ R ERERQ
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 244 ERERQE--QLEREQLEWERERR 263
RE +E Q E + L ERE+R
Sbjct: 1110 CREEEELQQEEEQLLREEREKR 1131
Score = 78.2 bits (191), Expect = 2e-14
Identities = 58/138 (42%), Positives = 84/138 (60%), Gaps = 12/138 (8%)
Query: 137 QEELEIQRRQLQEQQRQK----ELERERLERERMERERL-ERERLERERLERERLEQEQL 191
+EE E +RRQ E+Q +K + E E+L RE E+ RL ERER RE E ++ E+EQL
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ-EEEQL 1063
Query: 192 ERERQERERQERLERQERLERQERLERQE--RLDRERQERQERERLERLERERQERE--- 246
E +E R++ LERQ R E + + E ++ R + E++ RQERER R E E Q+ E
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 247 -RQEQLEREQLEWERERR 263
R+E+ +R + E ER+ R
Sbjct: 1124 LREEREKRRRQELERQYR 1141
Score = 78.2 bits (191), Expect = 2e-14
Identities = 59/142 (41%), Positives = 86/142 (60%), Gaps = 16/142 (11%)
Query: 137 QEELEIQRRQLQEQQRQKEL--ERERLERE----RMERERL---ERERLERERLERERLE 187
++EL+ + QL ++R+K ERER RE + E E+L ERE R+ LER+ +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 188 QEQLERERQE--RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
+E+L++E ++ RE E+ RQER ERQ R E + + + E+ R+ERE+ R E ERQ R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQER-ERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 246 ERQE-QLEREQL---EWERERR 263
E +E Q E EQL E E+ RR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRR 1163
Score = 78.2 bits (191), Expect = 2e-14
Identities = 56/173 (32%), Positives = 95/173 (54%), Gaps = 21/173 (12%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
L QE L + + + + S++E + + R+ ++Q R++E ER+ LE E+ R+
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 171 LERERLERERLERERLEQE--QLERERQERERQERLERQER------------------L 210
R+ E E+L +ER EQ+ + ER+R+ E +++L RQER L
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 211 ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
E +++L RQ+R + QE Q+ R ER ++ RQ+R+R+ + E EQL ERE +
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR-EEEQLRQEREEQ 1570
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/153 (33%), Positives = 90/153 (58%), Gaps = 8/153 (5%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
L+ QE + ++ Q Q E+ + RRQ +QQ ++E +R+ E E++ +ER
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 171 LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERL------ERQERLDR 224
E ++L R+ +R+ LE+E R RQERE+Q R +R + +E+L ++ R +R
Sbjct: 1632 -EEQQLHRQERDRKFLEEEPQLR-RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 225 ERQERQERERLERLERERQERERQEQLEREQLE 257
+R+ R+E ++L R ERER+ + ++QL R++LE
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Score = 77.8 bits (190), Expect = 3e-14
Identities = 48/141 (34%), Positives = 81/141 (57%), Gaps = 7/141 (4%)
Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Q++ +E E Q R+ Q+ +R+++L RE+ R + R ++ R E++ ++L +E
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 190 QLERERQERERQERLERQERLERQERLERQERLD----RERQERQERERLERLERERQER 245
Q R QE ER E+ QER E++ + E++ER D E ER E+ER ++ + QE
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482
Query: 246 ERQE---QLEREQLEWERERR 263
ER+E +LE E+ ++ERR
Sbjct: 483 ERRERWLKLEEEERREQQERR 503
Score = 77.0 bits (188), Expect = 4e-14
Identities = 56/152 (36%), Positives = 88/152 (57%), Gaps = 11/152 (7%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ QL Q + +EE E +RRQ +E+Q +K+ + ++ E + + E +R R ERE+
Sbjct: 931 REEEQLQ-QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 182 ERE----RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER--QERERL 235
RE + E+EQL RE +E+ R++ ERQ R + + + E ++ L ER++R QERER
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 236 ERLERERQERERQ----EQLEREQLEWERERR 263
R E E Q+ E Q E+ R + E ER+ R
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/177 (30%), Positives = 91/177 (51%), Gaps = 27/177 (15%)
Query: 114 QETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER 173
+E G ++ + ++ G Q E + + Q Q+R +EL R+R E + E R E
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190
Query: 174 ERLE------------------RERLE---RERLEQEQLERERQERERQERLERQER--- 209
E+L+ RE LE + R E++Q RERQ+R QE E++ R
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 210 --LERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRI 264
L ++E ++E R+R+ ++E E+L +LER+ RERQE+ E++Q RE+++
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE-EQQQQRLRREQQL 306
Score = 76.3 bits (186), Expect = 8e-14
Identities = 48/148 (32%), Positives = 89/148 (60%), Gaps = 10/148 (6%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLER-------ERMERERLERERLERERLER--ERLE 187
+EE E ++ ++QQ +++ E ER ER ER E++ ++L RE+ ER +RL+
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 188 QEQLERERQERERQERLERQERLERQERL-ERQERLDRERQERQERERLERLERERQERE 246
+++ E Q+R R E+ R+E+ ER+E+L +R+E E++ R++R + E+ ER Q +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
R+E+ +++L+ E+E R+ VE
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVE 608
Score = 76.3 bits (186), Expect = 8e-14
Identities = 59/150 (39%), Positives = 87/150 (58%), Gaps = 28/150 (18%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE-------RLERERL--E 187
++E E Q+ QE+ R+ LE +++ R+ ER+ +E E+ R R ER+R E
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 188 QEQL--ERERQERERQER----LERQERLERQERLERQERLDRERQERQ--------ERE 233
EQL ERE Q+ RQER LE + +L RQER E+Q R DR+R+ R+ E +
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 234 RLERLERERQERERQEQLEREQLEWERERR 263
+L R ER+R+ RE ++QL R+ ERER+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQ----ERERK 1708
Score = 75.9 bits (185), Expect = 1e-13
Identities = 53/132 (40%), Positives = 79/132 (59%), Gaps = 7/132 (5%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERER---MERERLERERLERERLERERLEQ--EQLE 192
EE +++R++ + R++E + R ERER E ++L R+ LER+ E E+L Q EQ +
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 193 RERQERERQERLERQERLERQE-RLERQERLDRERQERQERERLERLERERQERERQEQL 251
RQER R+ E Q R ER+E +L RQER + R+E Q R+ E + QE +R+ +
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR- 1798
Query: 252 EREQLEWERERR 263
E EQL ERE +
Sbjct: 1799 EEEQLRQEREEQ 1810
Score = 75.5 bits (184), Expect = 1e-13
Identities = 53/153 (34%), Positives = 90/153 (58%), Gaps = 16/153 (10%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER-LERER 180
R+ QL Q ++ EE +QL+ Q+R ++ + L + ER+ LE E+ L R++
Sbjct: 1473 REEQQLHRQERDRKFLEE----EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERL--ERQE----RLDRERQERQERER 234
+R+ L++EQ R RQER +Q R +R + +E+L ER+E R +R+R+ R E ++
Sbjct: 1529 RQRKFLQEEQQLR-RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 235 LERLERERQERERQEQLER----EQLEWERERR 263
+ R E+ER+ E ++QL R +QL ER+R+
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Score = 75.5 bits (184), Expect = 1e-13
Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 7/160 (4%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
L QE ++ QL Q +EE ++++ QEQ R++E R+ LE E++ ER
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 171 LERE--RLERERL--ERERLEQEQLERE--RQERERQERLERQERLERQE-RLERQERLD 223
E++ R ER+R E E+L QE+ E++ QE +R+ R E Q R ER+E +L Q+R
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 224 RERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
+ R E ++ + E+ +R RQER+RQ + E + E+ RR
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Score = 74.3 bits (181), Expect = 3e-13
Identities = 47/136 (34%), Positives = 80/136 (58%), Gaps = 14/136 (10%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+E E +R+QL + + Q+E +++L RE+ ER +RL+RE E ERLEQ +L+RE +
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERRE---QRLKREE-EEERLEQ-RLKREHE 677
Query: 197 ERERQERLERQERLERQERLER-----QERLDRERQERQE----RERLERLERERQERER 247
E R++ L +E+ + +ER++ Q +L+ E RQ R R + +R RQE+E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 248 QEQLEREQLEWERERR 263
+ + +L+W+ E R
Sbjct: 738 KRRRRESELQWQEEER 753
Score = 74.3 bits (181), Expect = 3e-13
Identities = 52/156 (33%), Positives = 89/156 (57%), Gaps = 14/156 (8%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ QL Q ++ EE RRQ +EQQ + + +R+ E E++ +E E++ +ER
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 182 ERERLEQEQLERERQERE--RQERLERQERLERQERLERQERLDRERQERQERERLERL- 238
+ R E++QL R+ +ER+ ++E+ R++ LER+ R E Q R + E+++ + +ER ++
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 239 -------ERERQERERQEQ----LEREQLEWERERR 263
ERE Q+ RQE+ E EQL ERE +
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786
Score = 73.2 bits (178), Expect = 6e-13
Identities = 53/156 (33%), Positives = 82/156 (52%), Gaps = 20/156 (12%)
Query: 137 QEELEIQRRQLQEQQRQ-----------KELERERLERERMERERLERERLERERLERER 185
QEE R+Q +E+QR+ E R+RL RE+ ER+ ER +RE+
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808
Query: 186 L----EQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
E+E+ +R RQ RER++ L+ E E+ +R ER ++L E QE + ER
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ-----ERR 863
Query: 242 RQERERQEQLEREQLEWERERRISSAAAPASVETPL 277
R + +R++Q R QLE ER+RR + A +++ L
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Score = 72.8 bits (177), Expect = 8e-13
Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 31/169 (18%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-ERLERERLERER 180
RQ + P Q + QE Q R+L E + Q E + +R+R R E L R+R E +
Sbjct: 127 RQLEEEPGQRRRQKRQE----QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE 182
Query: 181 LERERLEQEQLE----RERQERERQERLERQERLE---------RQERLERQERLDRERQ 227
E R E+EQL+ E +E +E+L R+E LE +Q+R ERQ+R+ +E +
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 228 ERQERER-------LERLERERQERERQEQLEREQL------EWERERR 263
E++ R+R E+L+ E +R+R+ Q E EQL E RER+
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291
Score = 72.8 bits (177), Expect = 8e-13
Identities = 48/149 (32%), Positives = 85/149 (57%), Gaps = 12/149 (8%)
Query: 129 AQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLE--------RER 180
++V + P ++E + +R++ +E++R++E E + E ER R++ E E+ E+
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
ER R R++RERQ R E +++ E++ E +E+ R RQ R+ + L+ LE
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 241 ER--QERERQEQLEREQ--LEWERERRIS 265
E Q RER +QL+ E+ L+ ++ERR S
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Score = 72.8 bits (177), Expect = 8e-13
Identities = 56/142 (39%), Positives = 85/142 (59%), Gaps = 17/142 (11%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERE----RMERERLERERLERERLERERL----EQ 188
++E +Q R+ Q+ RQ E +R+ LE E R ERE+ R +R+ E E+L E+
Sbjct: 1623 EDEQLLQEREEQQLHRQ-ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 189 EQL---ERERQERERQERLERQER----LERQERLERQERLDRERQERQERERLERLERE 241
+QL ER+R+ RE +++L RQER L+ +++L RQE + R+E Q R+ E+ +
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 242 RQERERQEQLEREQLEWERERR 263
RQER R + LE EQL ERE +
Sbjct: 1742 RQERYR-KILEEEQLRPEREEQ 1762
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/140 (40%), Positives = 86/140 (61%), Gaps = 16/140 (11%)
Query: 137 QEELEIQRRQ---LQEQQRQKELERERLERERMERERLERE-RLERERLERERLEQEQL- 191
+EE +Q R+ L+ Q+R ++ E L + R+ LE E RL R+ ER+ L++EQ
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 192 ---ERE---RQERERQERLERQERLERQERLERQERLDRERQERQERER--LERLERERQ 243
ERE RQ+R+R+ R E +++L RQER +R+ R + ++ RQERER LE ++ RQ
Sbjct: 1400 RCQEREQQLRQDRDRKFR-EEEQQLSRQER-DRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 244 ERERQEQLEREQLEWERERR 263
ER R+ + E EQL ERE +
Sbjct: 1458 ERHRKFR-EEEQLLQEREEQ 1476
Score = 72.4 bits (176), Expect = 1e-12
Identities = 55/161 (34%), Positives = 91/161 (56%), Gaps = 10/161 (6%)
Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERE---- 164
E L QE G + +L Q + +E + R Q +EQQ +++ +R+ E E
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Query: 165 RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQ-ERLD 223
R ER+R RE E +++ R+ E++ LE E+Q R+ + R R+E QER E+Q R +
Sbjct: 1425 RQERDRKFRE--EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 224 RERQERQERERLERLERERQERE---RQEQLEREQLEWERE 261
R+R+ +E ++L R ER+R+ RE R ++ ER+ LE E++
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ 1523
Score = 72.4 bits (176), Expect = 1e-12
Identities = 56/168 (33%), Positives = 91/168 (54%), Gaps = 15/168 (8%)
Query: 111 LNSQETGPTLPRQNSQLPAQVQNGPSQEE-----LEIQRRQLQEQQRQKELERERLERER 165
L+ QE + Q+ Q + EE E R+ +E+Q +E E ++L R+
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 166 MERERLERER-LERERLERERLEQE--QLERERQERERQERLERQER----LERQERLER 218
+R+ LE E+ L R+ +R+ EQE E ER+ E +++L RQ+R L+ +++L R
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 219 QERLDRERQERQERERLE---RLERERQERERQEQLEREQLEWERERR 263
QER + RQ+R + R E R ERE Q+ RQE+ + +LE ++ RR
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/148 (37%), Positives = 84/148 (56%), Gaps = 22/148 (14%)
Query: 137 QEELEIQRR----QLQEQQRQKELERERLERERMERERLERERLERERLERERLE----- 187
+EE ++QRR QLQE++ + ++ER + R++ R +LE ER R
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 188 -QEQLERERQE-RERQERLERQERLERQERLERQERLDRERQERQERERLERLERE---R 242
QEQL +E+Q +E +E L+R+ER E++ R E++ + E Q +QE E+L R ERE R
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREER-EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 243 QERERQ-------EQLEREQLEWERERR 263
QERERQ +Q E + L E E+R
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKR 981
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/155 (30%), Positives = 89/155 (57%), Gaps = 10/155 (6%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERE-----RLERERL 176
RQ + + + QEE ++ R + +E++R++ELER+ E E +++E R E E+
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREE-REKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 177 ERERLERERLEQEQLERERQERERQERLERQERLERQ----ERLERQERLDRERQERQER 232
R+ LER+ E+E+L++E ++ R+E+ +R++ ERQ E L+RQ+R R R E Q
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 233 ERLERLERERQERERQEQLEREQLEWERERRISSA 267
+ + E E++ R ++ + E E+ R++ +
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/141 (33%), Positives = 85/141 (60%), Gaps = 13/141 (9%)
Query: 135 PSQEELEIQRRQLQEQQRQKELERERLERERMER-ERLERER------LERERLERERLE 187
P +EE E +RRQ +E++++ + E + +R ER ++L+ E ER R + +R +
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 188 QE---QLERERQERERQ--ERLERQERLERQERLERQERLDRERQERQERERLERLERER 242
Q+ QLE ER+ R + QE+L ++++L ++E + +R+ER++R R E+ ER+
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ-ERQY 930
Query: 243 QERERQEQLEREQLEWERERR 263
+E E+ +Q E + L ERE+R
Sbjct: 931 REEEQLQQEEEQLLREEREKR 951
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/157 (35%), Positives = 91/157 (57%), Gaps = 10/157 (6%)
Query: 114 QETGPTLPRQNSQLPAQVQNGPSQEELEIQRR---QLQEQQRQKELERERLERERMERER 170
QE + QL + +EE +Q R QL Q+R ++ E + R ER+R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 171 LERER-LERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
RE+ L + ER+ LE+EQ + RQ+R+R+ L+ +++L RQER +Q R DR+R+ R
Sbjct: 1502 KFREQELRSQEPERKFLEEEQ-QLHRQQRQRKF-LQEEQQLRRQER-GQQRRQDRDRKFR 1558
Query: 230 QERE-RLERLERE--RQERERQEQLEREQLEWERERR 263
+E + R ER E++ RQER+R+ +LE +++ + + R
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Score = 70.1 bits (170), Expect = 5e-12
Identities = 58/161 (36%), Positives = 88/161 (54%), Gaps = 33/161 (20%)
Query: 135 PSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER-----LERERLE-RERLEQ 188
P +E+ E Q R + QQR++ E E+E+ R+R ERE+ E E+L+ RER +Q
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 189 EQLE----RERQERERQERLER---------QERLER----------QERLERQERLDRE 225
Q E +E QER R + R +ER R QE+L ++++L +E
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 226 RQE---RQERERLERLERERQERERQEQLEREQLEWERERR 263
+E R+ERE+ R E+ERQ RE +EQL++E+ + RE R
Sbjct: 909 EEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLREER 948
Score = 70.1 bits (170), Expect = 5e-12
Identities = 61/180 (33%), Positives = 99/180 (55%), Gaps = 36/180 (20%)
Query: 122 RQNSQL----PAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERE-R 175
R+N Q +Q+++ SQ++L+ + QE+ R++E R ++ +R E E+LERE +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 176 LERERLERERLEQEQLERE-------RQERERQERLERQERLERQER-LERQERLDRERQ 227
E +R +R+ E++QL RE RQE +R+ R E Q ER+E+ L RQER + R+
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 228 ER-----------QERERLERLERER-----------QERERQEQLEREQLEWERERRIS 265
E +E +RL R ERER QERE+Q + +R++ E E+++S
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Score = 67.8 bits (164), Expect = 3e-11
Identities = 53/147 (36%), Positives = 81/147 (55%), Gaps = 19/147 (12%)
Query: 137 QEELEIQRRQLQEQQR----QKELERERLERERMERERLERERLERERL--ERERLEQEQ 190
+E L RRQ ++Q+R ++LE E +R R +R+ ERE E E ++ERLEQ
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 191 LERE-----RQERERQERLER---QERLERQERLERQERLDRE---RQERQERERLERLE 239
+R RQ +E QER ER +E+L+ + E +E D E R+E E R R E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 240 RERQERERQEQL--EREQLEWERERRI 264
+++Q RERQ+++ E E+ EW + +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETV 252
Score = 67.8 bits (164), Expect = 3e-11
Identities = 48/126 (38%), Positives = 74/126 (58%), Gaps = 8/126 (6%)
Query: 141 EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERE--RQER 198
E + +QL Q+R ++ E + R ERE+ R +R+ E E+L QE E++ RQER
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 199 ERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEW 258
+R+ R E +++L RQER ER+ + ++ RQE ER R E + ++ QEQL R+
Sbjct: 1690 DRKFR-EEEQQLRRQER-ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ---- 1743
Query: 259 ERERRI 264
ER R+I
Sbjct: 1744 ERYRKI 1749
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/178 (30%), Positives = 93/178 (52%), Gaps = 36/178 (20%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERME------------ 167
L ++ QL + Q QE E Q R+ +E QRQK +R R E +R +
Sbjct: 1176 LQQEEEQLLREEQEKRRQER-ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 168 ----------RERLERERLERERLERERLEQEQLER---ERQERERQERLERQERLER-- 212
RE + +LE +L R+R Q+ L+ E+QER+R++ R ++ +R
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 213 --QERLERQERLDRERQERQERERLERLERERQERERQEQLER-----EQLEWERERR 263
+E+LER+E+ + +R++R+ +E + L ER+E+ R+++ +R EQL ERE +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Score = 67.0 bits (162), Expect = 5e-11
Identities = 51/136 (37%), Positives = 83/136 (61%), Gaps = 13/136 (9%)
Query: 137 QEELEIQ---RRQLQEQQRQKELERER--LERERMERERLERERLERERLERERLEQEQL 191
+EEL Q R+ L+E+QR + ERER L+ E+ R + ++L ++R + R E++QL
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 192 ERERQERERQERLERQERLERQER----LERQERLDRERQERQERERLERLERERQERER 247
R QER+R+ R E ++++ RQER LE +++L +ER + E ERE Q+ R
Sbjct: 1424 SR--QERDRKFR-EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 248 QEQLEREQLEWERERR 263
QE+ +R+ LE E++ R
Sbjct: 1481 QER-DRKFLEEEQQLR 1495
Score = 66.2 bits (160), Expect = 8e-11
Identities = 55/159 (34%), Positives = 85/159 (53%), Gaps = 21/159 (13%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER- 195
+ E + +RRQ Q ++ Q+E +RL+RE E ERLE +RL+RE E ER EQE E E+
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREE-EEERLE-QRLKREH-EEERREQELAEEEQE 691
Query: 196 QERER--------QERLE-----RQERLERQERLERQERLDRERQERQER--ERLERLER 240
Q RER Q +LE RQ ++ + R + +R +E++E++ R L+ E
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 241 ERQERERQEQLEREQL--EWERERRISSAAAPASVETPL 277
ER R++QE+ +R +W+ E + S PL
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Score = 65.5 bits (158), Expect = 1e-10
Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 23/166 (13%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKEL---------ERERLERERMERER 170
L ++ QL + + ++ELE Q R+ +E Q+++E R+ LER+ E E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 171 L--ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
L E E+L RE E+ R E+E+ RE +E +RQ+R +R +++ L+ Q ++E
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 229 R--------QERERLERLE----RERQERERQEQLEREQLEWERER 262
R +E E+ +LE R+RQ ++ + L EQ E +RE+
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Score = 64.3 bits (155), Expect = 3e-10
Identities = 49/133 (36%), Positives = 71/133 (53%), Gaps = 12/133 (9%)
Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQLERERQERE 199
Q L E++R + +E L ++R + E R +LE E R Q++ E+ER+ E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 200 RQERLERQERLERQERLERQERLDRERQERQERERLERLE--------RERQERERQEQL 251
+E+ E+QERLE+++R R E L R+RQE QERE E E +E +EQL
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 252 -EREQLEWERERR 263
RE LE R+ R
Sbjct: 211 RRRELLELRRKGR 223
Score = 64.3 bits (155), Expect = 3e-10
Identities = 47/130 (36%), Positives = 79/130 (60%), Gaps = 13/130 (10%)
Query: 141 EIQRRQLQEQQRQKELERERLE-RERMERERLERERLERERLERERLEQEQLERERQERE 199
E QR + QE++R+ E ++L +ER ++ R +R+R RE E ++L +++ +R+ +E E
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE--EEQQLSRQERDRKFREEE 1436
Query: 200 RQERLERQERL----ERQERLERQERLDRERQERQERE--RLERLERERQERERQEQLER 253
+Q R + +ER E+Q R ER + E Q QERE +L R ER+R+ E ++QL R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 254 EQLEWERERR 263
+ ER+R+
Sbjct: 1497 Q----ERDRK 1502
Score = 61.6 bits (148), Expect = 2e-09
Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 47/174 (27%)
Query: 137 QEELEIQRRQ-LQEQQRQKE---LERERLERERMERERLERERLERERLERERLEQEQLE 192
+EE E +RRQ L+ Q R++E E E+L RE E+ R ERER RE E +R +++Q
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 193 RERQER---------------------------------ERQERLERQERLERQERLERQ 219
R+ +R E + +RQ + + Q L Q
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 220 ERLDRERQER--QERER----LERLERERQE----RERQEQLEREQLEWERERR 263
+ DRE++ R Q+R+R E+LERE Q+ R+R+ Q E++ L ERE +
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Score = 55.1 bits (131), Expect = 2e-07
Identities = 54/201 (26%), Positives = 92/201 (45%), Gaps = 56/201 (27%)
Query: 118 PTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER--------ERMERE 169
P R+ L ++ Q Q++L ++++ +EQ+ ++E E ERLE+ ER E+E
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 170 RLERERLE-RERL-------------------------------ERERLEQEQLERER-- 195
E E+ + RER+ +R R EQE+ R R
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 196 ------------QERERQERLERQERLERQERLER-QERLDRERQERQERERLERLERER 242
Q++E ++R + + + +E+ ER ++RL R++RER R E ER
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ER 803
Query: 243 QERERQEQLEREQLEWERERR 263
Q+RE++ E E+ E R +R
Sbjct: 804 QQREQRFLPEEEEKEQRRRQR 824
Score = 29.6 bits (65), Expect = 8.1
Identities = 15/55 (27%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 211 ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS 265
E++ R + +E L ++R++ +++ R E +R+ +E Q R Q E+ER ++
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR---RRQKRQEQERELA 149
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 97.8 bits (242), Expect = 2e-20
Identities = 125/495 (25%), Positives = 196/495 (39%), Gaps = 80/495 (16%)
Query: 134 GPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERER---LERERLERERLEQEQ 190
G E +Q + + +E ERER ERE +RER ERER ERER +RER + +
Sbjct: 382 GGQYENFRVQYTETEPYHNYRERERER-ERENRQRER-ERERERDRERERRQRERERERE 439
Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
ER+++ + R+E ER ER +R E+ +RQ R DR+R++ +E+E+ + R Q RQ +
Sbjct: 440 HERDKERQRRKEEWER-ERAKRDEK-DRQHR-DRDREKEREKEKGKPKPRSPQPPSRQAE 496
Query: 251 LEREQL-----------EWE-----------------------RERRISSAAAPASVETP 276
+++ EW+ R R+ S+++A AS +
Sbjct: 497 PPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSR 556
Query: 277 LNSVLGD-----SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALP 331
+S SS S + S + S+ G + S +
Sbjct: 557 SSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRS-----------RSRSFSSS 605
Query: 332 PPPGPPPPPPLPS--TGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPL 389
P P P P P PS T P PPP + P PPPAPP A + E +P
Sbjct: 606 PSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKT--TAPVPEPTKPG 663
Query: 390 TGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMS 449
A R R S G+ + +SS++ + L S + S
Sbjct: 664 DPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRS--------LSVSSVSSVSS 715
Query: 450 ALLARRRRIAEKGSTIETEQKEDKGED-SEPVTSKASSTSTPEPTRKPWERTNTMNGSKS 508
A S+ + ED D + PV+S +S + P TRK ++ +G K
Sbjct: 716 A--------TSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKE 767
Query: 509 PVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRK 568
R S + + S +P STP P Q + + +K +L++
Sbjct: 768 EKRKRDSSTQPPKSAKPPAGGKSSQQP-STPQQAPPGQPQQGTFVAHKEIKLTLLNKAAD 826
Query: 569 ELTKLKEELIDAIRQ 583
+ ++ + E D RQ
Sbjct: 827 KGSRKRYEPSDKDRQ 841
Score = 36.2 bits (82), Expect = 0.087
Identities = 58/250 (23%), Positives = 88/250 (35%), Gaps = 25/250 (10%)
Query: 134 GPSQEELEIQRRQLQEQQRQKELERERLERERMERER--------LERERLERERLERER 185
GPSQEE + E+ R E + + + E E R E + E +R R
Sbjct: 57 GPSQEE---EDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLR 113
Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
E + RE E E L+ E + + QE + + E+ E RE +
Sbjct: 114 DEASSVTRELDEHE----LDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKA 169
Query: 246 ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQG 305
Q E+E LE +E++ + L + +P + + P+ +
Sbjct: 170 GVQSVGEKESLEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDP---SDRKVRPRPTCRF 226
Query: 306 IVLGPLAPPPPPPL--PPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQV--- 360
+ G P + + +L P PP P GP P P P V
Sbjct: 227 FMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPPLGPHPLMPANPWGGPVVDE 286
Query: 361 --PPPPPPPP 368
PPPPP PP
Sbjct: 287 ILPPPPPEPP 296
Score = 32.0 bits (71), Expect = 1.6
Identities = 60/290 (20%), Positives = 108/290 (37%), Gaps = 33/290 (11%)
Query: 78 HQWRDARQVYGLN-------FGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQ 130
H D Q GL+ GS +D + A LE S GP+ +++ +
Sbjct: 12 HSPEDEEQPQGLSDDDILRDSGSDQDLDG-AGVRASDLEDEESAARGPSQEEEDNH--SD 68
Query: 131 VQNGPSQEELEIQRRQLQEQQRQK-----ELERERLERERMERERLERERLERERLERER 185
++ S+ + + Q ++ E R E E + E +R R E + RE E E
Sbjct: 69 EEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRDEASSVTRELDEHEL 128
Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRER--QERQERERLERLERERQ 243
E++ E +++ E+ + +E+ E R + + Q E+E LE + +++
Sbjct: 129 DYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPREEGKAGVQSVGEKESLEAAKEKKK 188
Query: 244 ERERQE---------QLEREQLEWERERRISSAAA-----PASVETPLNSVLGDSSASEP 289
E + E LE +++ +R++ + +N ++
Sbjct: 189 EDDDGEIDDGEIDDDDLEEGEVKDPSDRKVRPRPTCRFFMKGNCTWGMNCRFIHPGVNDK 248
Query: 290 GLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPP 339
G + A+ G PL P P P P + PPP P PP
Sbjct: 249 GNYSLITKADPFPPNGAP--PLGPHPLMPANPWGGPVVDEILPPPPPEPP 296
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 54/151 (35%), Gaps = 6/151 (3%)
Query: 344 STGPPPPPPPPPLPNQVPPPPPPPPAPP-LPASGFFLASMSEDNRPLTGLAAAIAGAKLR 402
ST PP PP P P APP P G F+A E L AA K
Sbjct: 775 STQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAH-KEIKLTLLNKAADKGSRKRY 833
Query: 403 KVSRMEDTSFPSG--GNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAE 460
+ S + S P N + + GR P P G + A A R+R
Sbjct: 834 EPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLS 893
Query: 461 KGSTIETEQKEDKGEDSEP--VTSKASSTST 489
S ++ G+ S+P ++K+ ST
Sbjct: 894 PQSKSSSKVTSVPGKASDPGAASTKSGKAST 924
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 94.4 bits (233), Expect = 3e-19
Identities = 58/140 (41%), Positives = 87/140 (62%), Gaps = 20/140 (14%)
Query: 132 QNGPSQEELEIQRRQLQ-------EQQRQKELERERLERERMERERLERERLERERL-ER 183
Q P + LE +++QL+ E ++++ ER LE E+ + LE++R E+ERL +
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386
Query: 184 ERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ 243
ER EQE+ ERERQE+ER+ +LE +++LE+Q LERQ +E + R+ +ER E ++
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQRELERQ-------REEERRKEIERREAAKR 439
Query: 244 ERERQEQLEREQLEWERERR 263
E ERQ QLEWER RR
Sbjct: 440 ELERQ-----RQLEWERNRR 454
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/131 (39%), Positives = 81/131 (61%), Gaps = 19/131 (14%)
Query: 139 ELEIQRRQLQEQQRQKE--------LERERLERERMERERLERERLERERLERERLEQEQ 190
ELE +R+ L EQQR+++ E+ER ERER E+ER + LE++ LE++R +
Sbjct: 364 ELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----E 418
Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
LER+R+E ER++ +ER+E +R+ LERQ +L+ ER RQE L + QE +
Sbjct: 419 LERQREE-ERRKEIERREAAKRE--LERQRQLEWERNRRQE---LLNQRNKEQEDIVVLK 472
Query: 251 LEREQLEWERE 261
+++ LE+E E
Sbjct: 473 AKKKTLEFELE 483
Score = 63.5 bits (153), Expect = 5e-10
Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 7/136 (5%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R N +L + Q Q+ E +R E+ Q+ ERER E+ER + LE++ ++ L
Sbjct: 360 RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQREL 419
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE----RERLER 237
ER+R E+ + E ER+E ++E LERQ +LE ER RQE L++ +E+++ + + +
Sbjct: 420 ERQREEERRKEIERREAAKRE-LERQRQLE-WERNRRQELLNQRNKEQEDIVVLKAKKKT 477
Query: 238 LERERQE-RERQEQLE 252
LE E + +++ QLE
Sbjct: 478 LEFELEALNDKKHQLE 493
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/142 (31%), Positives = 79/142 (55%), Gaps = 6/142 (4%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE 179
L +Q + Q +++E + + RQ QE++RQ ELE++ LE++R LER+R E
Sbjct: 373 LEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----ELERQREEER 427
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
R E ER E + E ERQ + ER RQE L ++ + E+++ + + +++ LE L
Sbjct: 428 RKEIERREAAKRELERQRQLEWERNRRQELLNQRNK-EQEDIVVLKAKKKTLEFELEALN 486
Query: 240 RERQERERQEQLEREQLEWERE 261
++ + E + Q R +L +R+
Sbjct: 487 DKKHQLEGKLQDIRCRLTTQRQ 508
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/123 (30%), Positives = 74/123 (60%), Gaps = 14/123 (11%)
Query: 124 NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE--RLERERMERERLERERLERERL 181
N+QL +++ ++++L+ Q+ E+ +QKE ER+ LE+++ E +R +ER
Sbjct: 604 NNQLK-ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER------ 656
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
+++ LE Q E E Q R +L +E+L+R+E +++++ ++ +QE Q ++L RL +
Sbjct: 657 DKQWLEHVQQEDEHQ---RPRKLHEEEKLKREESVKKKDGEEKGKQEAQ--DKLGRLFHQ 711
Query: 242 RQE 244
QE
Sbjct: 712 HQE 714
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/152 (22%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 112 NSQETGPTLPRQ---NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERME 167
+ Q G +P + N QL QN ++ L +R L+ ++ ++ R++L+ E+
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593
Query: 168 RERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQ 227
R +L+ + +L+ R + + ++Q+ ERL+++E+ + LE+Q+ + R
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 228 ERQERERLERLERERQERERQEQLEREQLEWE 259
+ ++++ LE +++E + + ++ E E+L+ E
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/116 (24%), Positives = 65/116 (56%), Gaps = 6/116 (5%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE 197
+E++I QL KEL +++ +++ +E ERL+++ ER+ +E E+ + E Q
Sbjct: 598 QEIDIFNNQL------KELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQR 651
Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
R ++ + E +++++ +R +L E + ++E ++ E+ ++E Q++L R
Sbjct: 652 RAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR 707
Score = 46.2 bits (108), Expect = 8e-05
Identities = 33/141 (23%), Positives = 76/141 (53%), Gaps = 24/141 (17%)
Query: 139 ELEIQRRQLQEQQR-------QKELERERLERERMERERLERERLE--RERLERERLEQE 189
E+ ++QLQE Q+ +K++ ++L++ +++ L R+ L + LE + L ++
Sbjct: 523 EITHLQQQLQESQQMLGRLIPEKQILNDQLKQ--VQQNSLHRDSLVTLKRALEAKELARQ 580
Query: 190 QLERERQERERQERLERQE------------RLERQERLERQERLDRERQERQERERLER 237
L + E E++ R + QE + +++L++Q+ ++ ER +++E+ER +
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER-KI 639
Query: 238 LERERQERERQEQLEREQLEW 258
+E E+Q+ E Q + + +W
Sbjct: 640 IELEKQKEEAQRRAQERDKQW 660
Score = 43.1 bits (100), Expect = 7e-04
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERER-LERE 179
++ + Q Q Q ELE Q + +E +RQ+E ER + +ER + LER+R LE E
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE 450
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
R R+ L Q +E+++ + ++ E + +++ +L+ + Q+ + R +R E
Sbjct: 451 RNRRQEL-LNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509
Query: 240 RERQERERQ 248
E + R+
Sbjct: 510 IESTNKSRE 518
Score = 30.8 bits (68), Expect = 3.7
Identities = 22/111 (19%), Positives = 58/111 (52%), Gaps = 16/111 (14%)
Query: 95 EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL-EIQRRQLQEQQRQ 153
++ ++F + + E+ N Q+ L +Q S +++ + ++ E+++++ + Q+R
Sbjct: 598 QEIDIFNNQLKELREIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 154 KELERERLE-----------RERMERERLERERLERERLERERLEQEQLER 193
+E +++ LE R+ E E+L+RE +++ E+ +QE ++
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDK 704
Score = 30.4 bits (67), Expect = 4.8
Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 12/118 (10%)
Query: 296 QPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355
QP S +G +A +PP A A V + P P L S+ P PP
Sbjct: 105 QPVAISSAPAFGMGGIAS-----MPPLTAVAPVPMGSIPVVGMSPTLVSS--VPTAAVPP 157
Query: 356 LPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 413
L N PP P PA PA+ +S + P + L KL+K + S P
Sbjct: 158 LANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQL-----NTKLQKAQSFDVASVP 210
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 94.4 bits (233), Expect = 3e-19
Identities = 58/140 (41%), Positives = 87/140 (62%), Gaps = 20/140 (14%)
Query: 132 QNGPSQEELEIQRRQLQ-------EQQRQKELERERLERERMERERLERERLERERL-ER 183
Q P + LE +++QL+ E ++++ ER LE E+ + LE++R E+ERL +
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386
Query: 184 ERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ 243
ER EQE+ ERERQE+ER+ +LE +++LE+Q LERQ +E + R+ +ER E ++
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQRELERQ-------REEERRKEIERREAAKR 439
Query: 244 ERERQEQLEREQLEWERERR 263
E ERQ QLEWER RR
Sbjct: 440 ELERQ-----RQLEWERNRR 454
Score = 68.6 bits (166), Expect = 2e-11
Identities = 52/131 (39%), Positives = 81/131 (61%), Gaps = 19/131 (14%)
Query: 139 ELEIQRRQLQEQQRQKE--------LERERLERERMERERLERERLERERLERERLEQEQ 190
ELE +R+ L EQQR+++ E+ER ERER E+ER + LE++ LE++R +
Sbjct: 364 ELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----E 418
Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
LER+R+E ER++ +ER+E +R+ LERQ +L+ ER RQE L + QE +
Sbjct: 419 LERQREE-ERRKEIERREAAKRE--LERQRQLEWERNRRQE---LLNQRNKEQEDIVVLK 472
Query: 251 LEREQLEWERE 261
+++ LE+E E
Sbjct: 473 AKKKTLEFELE 483
Score = 63.5 bits (153), Expect = 5e-10
Identities = 47/136 (34%), Positives = 79/136 (58%), Gaps = 7/136 (5%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R N +L + Q Q+ E +R E+ Q+ ERER E+ER + LE++ ++ L
Sbjct: 360 RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQREL 419
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE----RERLER 237
ER+R E+ + E ER+E ++E LERQ +LE ER RQE L++ +E+++ + + +
Sbjct: 420 ERQREEERRKEIERREAAKRE-LERQRQLE-WERNRRQELLNQRNKEQEDIVVLKAKKKT 477
Query: 238 LERERQE-RERQEQLE 252
LE E + +++ QLE
Sbjct: 478 LEFELEALNDKKHQLE 493
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/142 (31%), Positives = 79/142 (55%), Gaps = 6/142 (4%)
Query: 120 LPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERE 179
L +Q + Q +++E + + RQ QE++RQ ELE++ LE++R LER+R E
Sbjct: 373 LEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ-LEKQR----ELERQREEER 427
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
R E ER E + E ERQ + ER RQE L ++ + E+++ + + +++ LE L
Sbjct: 428 RKEIERREAAKRELERQRQLEWERNRRQELLNQRNK-EQEDIVVLKAKKKTLEFELEALN 486
Query: 240 RERQERERQEQLEREQLEWERE 261
++ + E + Q R +L +R+
Sbjct: 487 DKKHQLEGKLQDIRCRLTTQRQ 508
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/123 (30%), Positives = 74/123 (60%), Gaps = 14/123 (11%)
Query: 124 NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE--RLERERMERERLERERLERERL 181
N+QL +++ ++++L+ Q+ E+ +QKE ER+ LE+++ E +R +ER
Sbjct: 604 NNQLK-ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER------ 656
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERE 241
+++ LE Q E E Q R +L +E+L+R+E +++++ ++ +QE Q ++L RL +
Sbjct: 657 DKQWLEHVQQEDEHQ---RPRKLHEEEKLKREESVKKKDGEEKGKQEAQ--DKLGRLFHQ 711
Query: 242 RQE 244
QE
Sbjct: 712 HQE 714
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/152 (22%), Positives = 81/152 (53%), Gaps = 4/152 (2%)
Query: 112 NSQETGPTLPRQ---NSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERME 167
+ Q G +P + N QL QN ++ L +R L+ ++ ++ R++L+ E+
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593
Query: 168 RERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQ 227
R +L+ + +L+ R + + ++Q+ ERL+++E+ + LE+Q+ + R
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 228 ERQERERLERLERERQERERQEQLEREQLEWE 259
+ ++++ LE +++E + + ++ E E+L+ E
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/116 (24%), Positives = 65/116 (56%), Gaps = 6/116 (5%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE 197
+E++I QL KEL +++ +++ +E ERL+++ ER+ +E E+ + E Q
Sbjct: 598 QEIDIFNNQL------KELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQR 651
Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
R ++ + E +++++ +R +L E + ++E ++ E+ ++E Q++L R
Sbjct: 652 RAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGR 707
Score = 46.2 bits (108), Expect = 8e-05
Identities = 33/141 (23%), Positives = 76/141 (53%), Gaps = 24/141 (17%)
Query: 139 ELEIQRRQLQEQQR-------QKELERERLERERMERERLERERLE--RERLERERLEQE 189
E+ ++QLQE Q+ +K++ ++L++ +++ L R+ L + LE + L ++
Sbjct: 523 EITHLQQQLQESQQMLGRLIPEKQILNDQLKQ--VQQNSLHRDSLVTLKRALEAKELARQ 580
Query: 190 QLERERQERERQERLERQE------------RLERQERLERQERLDRERQERQERERLER 237
L + E E++ R + QE + +++L++Q+ ++ ER +++E+ER +
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER-KI 639
Query: 238 LERERQERERQEQLEREQLEW 258
+E E+Q+ E Q + + +W
Sbjct: 640 IELEKQKEEAQRRAQERDKQW 660
Score = 43.1 bits (100), Expect = 7e-04
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERER-LERE 179
++ + Q Q Q ELE Q + +E +RQ+E ER + +ER + LER+R LE E
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWE 450
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
R R+ L Q +E+++ + ++ E + +++ +L+ + Q+ + R +R E
Sbjct: 451 RNRRQEL-LNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509
Query: 240 RERQERERQ 248
E + R+
Sbjct: 510 IESTNKSRE 518
Score = 30.8 bits (68), Expect = 3.7
Identities = 22/111 (19%), Positives = 58/111 (52%), Gaps = 16/111 (14%)
Query: 95 EDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL-EIQRRQLQEQQRQ 153
++ ++F + + E+ N Q+ L +Q S +++ + ++ E+++++ + Q+R
Sbjct: 598 QEIDIFNNQLKELREIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 154 KELERERLE-----------RERMERERLERERLERERLERERLEQEQLER 193
+E +++ LE R+ E E+L+RE +++ E+ +QE ++
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDK 704
Score = 30.4 bits (67), Expect = 4.8
Identities = 34/118 (28%), Positives = 45/118 (38%), Gaps = 12/118 (10%)
Query: 296 QPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPP 355
QP S +G +A +PP A A V + P P L S+ P PP
Sbjct: 105 QPVAISSAPAFGMGGIAS-----MPPLTAVAPVPMGSIPVVGMSPTLVSS--VPTAAVPP 157
Query: 356 LPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFP 413
L N PP P PA PA+ +S + P + L KL+K + S P
Sbjct: 158 LANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQL-----NTKLQKAQSFDVASVP 210
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 94.0 bits (232), Expect = 4e-19
Identities = 58/136 (42%), Positives = 92/136 (67%), Gaps = 8/136 (5%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERL----ERERLERERLERERLEQEQLER 193
++ E +RR + Q++KE E+ERL R+ E +RL E+ER E+ER E+ER EQE+ E+
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERL-RKAAEAKRLAEQREQERREQERREQERREQERREQ 710
Query: 194 ERQERERQERLERQERLERQERLERQERL-DRERQERQERERLERLERERQERERQEQLE 252
ER+E+ERQ L QER QERL+ + L +RE+ R ++E+L+R E++++E Q++L
Sbjct: 711 ERREQERQ--LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 768
Query: 253 REQLEWERERRISSAA 268
QL+ E+E++ AA
Sbjct: 769 ERQLQEEQEKKAKEAA 784
Score = 84.7 bits (208), Expect = 2e-16
Identities = 51/131 (38%), Positives = 85/131 (64%), Gaps = 14/131 (10%)
Query: 137 QEELEIQRRQLQEQQRQKELER-----------ERLERERMERERLERERLERERLERER 185
QEE E + ++L ++++++E ER E+ E+ER E+ER E+ER E+ER E+ER
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 186 LEQEQLERERQERERQERLERQERLERQERLER--QERLDRERQERQERERLERLERERQ 243
EQE+ E++ R QERL+ + L+ +E+ R +E+L RE +E++++E +RL ERQ
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQ 771
Query: 244 ERERQEQLERE 254
+E QE+ +E
Sbjct: 772 LQEEQEKKAKE 782
Score = 75.1 bits (183), Expect = 2e-13
Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 11/152 (7%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-------ERLERE 174
R+ Q +V+ +++ +I+++ Q ++ ++ + ERL E+ ++ E +E
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 638
Query: 175 RLERERLERER-LEQEQLERERQERERQERLERQERLERQ---ERLERQERLDRERQERQ 230
R + E R R L+QE+ ER QE ++++ E QERL + +RL Q +R QER+
Sbjct: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Query: 231 ERERLERLERERQERERQEQLEREQLEWERER 262
E+ER E+ RE++ RE++ QL ++ E+ER
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQER 730
Score = 72.8 bits (177), Expect = 8e-13
Identities = 45/148 (30%), Positives = 92/148 (62%), Gaps = 5/148 (3%)
Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE-RERLERERLERERLEQ 188
+++N +EE E RRQ E+ +++ LE +L+RE R+ L+ RER+E+ + E+++ +
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 600
Query: 189 EQLER--ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERE 246
++ + E+ E+ ++ERL +E+ +++ ++ E ++ R++ +E RL L++E +ER
Sbjct: 601 QKFAQIDEKTEKAKEERL-AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
QE L++++ E E+ER +A A E
Sbjct: 660 HQELLQKKK-EEEQERLRKAAEAKRLAE 686
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/115 (42%), Positives = 73/115 (63%), Gaps = 11/115 (9%)
Query: 130 QVQNGPSQEELE--IQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERE 184
Q + QE L + ++L EQ+ Q+ E+ER E+ER E+ER E+ER E+ER +
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724
Query: 185 RLEQEQL--ERERQERERQERLER---QERLERQERLERQERLDRERQERQERER 234
R EQE+L ERE QERE+ RL++ Q LE +++ E Q+RL ERQ ++E+E+
Sbjct: 725 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL-AERQLQEEQEK 778
Score = 43.1 bits (100), Expect = 7e-04
Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 18/102 (17%)
Query: 191 LERERQERERQERLERQERLERQ----ERLERQERLDRERQER-----QERERLERLERE 241
+E+ERQ E R E E+L RQ ++ R E + +R+ER Q RER+E+++ E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 242 RQER---------ERQEQLEREQLEWERERRISSAAAPASVE 274
++++ E+ E+ + E+L E+ ++ ++A VE
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 636
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/75 (29%), Positives = 48/75 (64%), Gaps = 5/75 (6%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ + A+ + QE L+ +R +LQE+++ L++E+L+RE E+++ E E++RL
Sbjct: 713 REQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKE----EQQRL 767
Query: 182 ERERLEQEQLERERQ 196
+L++EQ ++ ++
Sbjct: 768 AERQLQEEQEKKAKE 782
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 94.0 bits (232), Expect = 4e-19
Identities = 58/136 (42%), Positives = 92/136 (67%), Gaps = 8/136 (5%)
Query: 138 EELEIQRRQLQEQQRQKELERERLERERMERERL----ERERLERERLERERLEQEQLER 193
++ E +RR + Q++KE E+ERL R+ E +RL E+ER E+ER E+ER EQE+ E+
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERL-RKAAEAKRLAEQREQERREQERREQERREQERREQ 706
Query: 194 ERQERERQERLERQERLERQERLERQERL-DRERQERQERERLERLERERQERERQEQLE 252
ER+E+ERQ L QER QERL+ + L +RE+ R ++E+L+R E++++E Q++L
Sbjct: 707 ERREQERQ--LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 764
Query: 253 REQLEWERERRISSAA 268
QL+ E+E++ AA
Sbjct: 765 ERQLQEEQEKKAKEAA 780
Score = 84.7 bits (208), Expect = 2e-16
Identities = 51/131 (38%), Positives = 85/131 (64%), Gaps = 14/131 (10%)
Query: 137 QEELEIQRRQLQEQQRQKELER-----------ERLERERMERERLERERLERERLERER 185
QEE E + ++L ++++++E ER E+ E+ER E+ER E+ER E+ER E+ER
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
Query: 186 LEQEQLERERQERERQERLERQERLERQERLER--QERLDRERQERQERERLERLERERQ 243
EQE+ E++ R QERL+ + L+ +E+ R +E+L RE +E++++E +RL ERQ
Sbjct: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA-ERQ 767
Query: 244 ERERQEQLERE 254
+E QE+ +E
Sbjct: 768 LQEEQEKKAKE 778
Score = 75.1 bits (183), Expect = 2e-13
Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 11/152 (7%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER-------ERLERE 174
R+ Q +V+ +++ +I+++ Q ++ ++ + ERL E+ ++ E +E
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 634
Query: 175 RLERERLERER-LEQEQLERERQERERQERLERQERLERQ---ERLERQERLDRERQERQ 230
R + E R R L+QE+ ER QE ++++ E QERL + +RL Q +R QER+
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 231 ERERLERLERERQERERQEQLEREQLEWERER 262
E+ER E+ RE++ RE++ QL ++ E+ER
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQER 726
Score = 72.8 bits (177), Expect = 8e-13
Identities = 45/148 (30%), Positives = 92/148 (62%), Gaps = 5/148 (3%)
Query: 130 QVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE-RERLERERLERERLEQ 188
+++N +EE E RRQ E+ +++ LE +L+RE R+ L+ RER+E+ + E+++ +
Sbjct: 537 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 596
Query: 189 EQLER--ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERE 246
++ + E+ E+ ++ERL +E+ +++ ++ E ++ R++ +E RL L++E +ER
Sbjct: 597 QKFAQIDEKTEKAKEERL-AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
Query: 247 RQEQLEREQLEWERERRISSAAAPASVE 274
QE L++++ E E+ER +A A E
Sbjct: 656 HQELLQKKK-EEEQERLRKAAEAKRLAE 682
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/115 (42%), Positives = 73/115 (63%), Gaps = 11/115 (9%)
Query: 130 QVQNGPSQEELE--IQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERE 184
Q + QE L + ++L EQ+ Q+ E+ER E+ER E+ER E+ER E+ER +
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
Query: 185 RLEQEQL--ERERQERERQERLER---QERLERQERLERQERLDRERQERQERER 234
R EQE+L ERE QERE+ RL++ Q LE +++ E Q+RL ERQ ++E+E+
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL-AERQLQEEQEK 774
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/75 (29%), Positives = 48/75 (64%), Gaps = 5/75 (6%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ + A+ + QE L+ +R +LQE+++ L++E+L+RE E+++ E E++RL
Sbjct: 709 REQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELEEKKKKE----EQQRL 763
Query: 182 ERERLEQEQLERERQ 196
+L++EQ ++ ++
Sbjct: 764 AERQLQEEQEKKAKE 778
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 93.6 bits (231), Expect = 5e-19
Identities = 93/355 (26%), Positives = 148/355 (41%), Gaps = 85/355 (23%)
Query: 82 DARQVYGLNFGSKEDANV---FASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
D +V+ + + +D+ F S + H L V N E P + + +Q+ +
Sbjct: 380 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 439
Query: 139 ELEIQRRQLQ---EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
+ + + R LQ E + +++ ++E+ + LE+ +L+ E R L+ E + E
Sbjct: 440 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEK-KLDSELTARHELQVEMKKMES 498
Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
E++ Q+ ++ L +++ E+ D E + Q + +L +E ++ +++
Sbjct: 499 DFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMA---- 554
Query: 255 QLEWERERRISSAA--APASVET-----PLNSVLGDSSASEPGLQAASQPAETPSQQGIV 307
+S+AA P SV + P + GDS P A + TP
Sbjct: 555 --------SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGD-STTP------ 599
Query: 308 LGPLAPPPPPPLPPGPAQASVALPP---------PPGP-------PPPPPLP-------- 343
P PPPPPP PP P ++ PP PP P PPPPPLP
Sbjct: 600 --PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSP 657
Query: 344 -------STGPPPP--------PPPPPLPNQ--VPPPPP--------PPPAPPLP 373
+ PPPP PPPPPLP +PPPPP PPP PPLP
Sbjct: 658 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 712
Score = 87.4 bits (215), Expect = 3e-17
Identities = 66/237 (27%), Positives = 104/237 (43%), Gaps = 51/237 (21%)
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
++E E L + +++ + E+ + E +++L+ + + +++ ++ E ++L+ L+
Sbjct: 449 QIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQ 508
Query: 240 RERQERERQEQ---LEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAAS- 295
E+ ++Q E++ LE E + A L L D+ L AA+
Sbjct: 509 GEKDALHSEKQQIATEKQDLEAEVSQLTGEVAK-------LTKELEDAKKEMASLSAAAI 561
Query: 296 -QPAETPSQQGIVLGPLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPS---- 344
P PS+ + P APP P P PP P ++ PPPP PPPPPPLP
Sbjct: 562 TVPPSVPSRAPV---PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 618
Query: 345 TGPPPPP------PPPPLPNQ--VPPPPP------------------PPPAPPLPAS 375
+ PP P PPPPL +PPPPP PP PPLP S
Sbjct: 619 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGS 675
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/106 (44%), Positives = 52/106 (49%), Gaps = 22/106 (20%)
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPP-------PPPLPPGPAQASVALPPP--- 333
S +S PG A P P I P PPP PPP PP P +A + PPP
Sbjct: 656 SPSSLPGGTAIPPPPPLPGSARI---PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 712
Query: 334 --PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP----PPPAPPLP 373
PG PPPPP P GP PPPPP + +PPPPP P AP LP
Sbjct: 713 GGPGIPPPPPFPG-GPGIPPPPPGM--GMPPPPPFGFGVPAAPVLP 755
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/92 (34%), Positives = 33/92 (35%), Gaps = 20/92 (21%)
Query: 276 PLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG 335
PL G P A P P G GP PPPPP P PG
Sbjct: 684 PLPGSAGIPPPPPPLPGEAGMPPPPPPLPG---GPGIPPPPP------------FPGGPG 728
Query: 336 PPPPPPLPSTGPPPP-----PPPPPLPNQVPP 362
PPPPP PPPP P P LP + P
Sbjct: 729 IPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTP 760
Score = 35.0 bits (79), Expect = 0.19
Identities = 15/49 (30%), Positives = 30/49 (61%)
Query: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Q KE ++ R E+M R +L +E+ E+ERLE+++ ++ ++ + E
Sbjct: 1138 QAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDE 1186
Score = 32.7 bits (73), Expect = 0.96
Identities = 15/40 (37%), Positives = 32/40 (80%), Gaps = 2/40 (5%)
Query: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERL 186
++E Q+++E E E++ R ++ +E+ E+ERLE+++ +RE+L
Sbjct: 1140 VKENQKRRETE-EKMRRAKLAKEKAEKERLEKQQ-KREQL 1177
Score = 31.6 bits (70), Expect = 2.1
Identities = 13/34 (38%), Positives = 28/34 (82%), Gaps = 1/34 (2%)
Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERL 176
+RR+ +E+ R+ +L +E+ E+ER+E+++ +RE+L
Sbjct: 1145 KRRETEEKMRRAKLAKEKAEKERLEKQQ-KREQL 1177
Score = 31.2 bits (69), Expect = 2.8
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 20/149 (13%)
Query: 112 NSQETGPTLPRQNSQLPAQVQNGPS---QEELEIQRRQLQEQQRQKELERERLERERMER 168
N Q+ + +Q S + VQN P+ +++ +++ + Q++ + R+ ME
Sbjct: 1045 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1104
Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
L +E E + ++L E+ + L + Q E Q+R +E
Sbjct: 1105 --LYKELGEYFLFDPKKLSVEEFFMD---------LHNFRNMFLQAVKENQKR-----RE 1148
Query: 229 RQERERLERLERERQERER-QEQLEREQL 256
+E+ R +L +E+ E+ER ++Q +REQL
Sbjct: 1149 TEEKMRRAKLAKEKAEKERLEKQQKREQL 1177
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 93.6 bits (231), Expect = 5e-19
Identities = 93/355 (26%), Positives = 148/355 (41%), Gaps = 85/355 (23%)
Query: 82 DARQVYGLNFGSKEDANV---FASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQE 138
D +V+ + + +D+ F S + H L V N E P + + +Q+ +
Sbjct: 389 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 448
Query: 139 ELEIQRRQLQ---EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
+ + + R LQ E + +++ ++E+ + LE+ +L+ E R L+ E + E
Sbjct: 449 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEK-KLDSELTARHELQVEMKKMES 507
Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
E++ Q+ ++ L +++ E+ D E + Q + +L +E ++ +++
Sbjct: 508 DFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMA---- 563
Query: 255 QLEWERERRISSAA--APASVET-----PLNSVLGDSSASEPGLQAASQPAETPSQQGIV 307
+S+AA P SV + P + GDS P A + TP
Sbjct: 564 --------SLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGD-STTP------ 608
Query: 308 LGPLAPPPPPPLPPGPAQASVALPP---------PPGP-------PPPPPLP-------- 343
P PPPPPP PP P ++ PP PP P PPPPPLP
Sbjct: 609 --PPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSP 666
Query: 344 -------STGPPPP--------PPPPPLPNQ--VPPPPP--------PPPAPPLP 373
+ PPPP PPPPPLP +PPPPP PPP PPLP
Sbjct: 667 SSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 721
Score = 87.4 bits (215), Expect = 3e-17
Identities = 66/237 (27%), Positives = 104/237 (43%), Gaps = 51/237 (21%)
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
++E E L + +++ + E+ + E +++L+ + + +++ ++ E ++L+ L+
Sbjct: 458 QIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQ 517
Query: 240 RERQERERQEQ---LEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAAS- 295
E+ ++Q E++ LE E + A L L D+ L AA+
Sbjct: 518 GEKDALHSEKQQIATEKQDLEAEVSQLTGEVAK-------LTKELEDAKKEMASLSAAAI 570
Query: 296 -QPAETPSQQGIVLGPLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPS---- 344
P PS+ + P APP P P PP P ++ PPPP PPPPPPLP
Sbjct: 571 TVPPSVPSRAPV---PPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCI 627
Query: 345 TGPPPPP------PPPPLPNQ--VPPPPP------------------PPPAPPLPAS 375
+ PP P PPPPL +PPPPP PP PPLP S
Sbjct: 628 SSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGS 684
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/106 (44%), Positives = 52/106 (49%), Gaps = 22/106 (20%)
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPP-------PPPLPPGPAQASVALPPP--- 333
S +S PG A P P I P PPP PPP PP P +A + PPP
Sbjct: 665 SPSSLPGGTAIPPPPPLPGSARI---PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 721
Query: 334 --PGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPP----PPPAPPLP 373
PG PPPPP P GP PPPPP + +PPPPP P AP LP
Sbjct: 722 GGPGIPPPPPFPG-GPGIPPPPPGM--GMPPPPPFGFGVPAAPVLP 764
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/92 (34%), Positives = 33/92 (35%), Gaps = 20/92 (21%)
Query: 276 PLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPG 335
PL G P A P P G GP PPPPP P PG
Sbjct: 693 PLPGSAGIPPPPPPLPGEAGMPPPPPPLPG---GPGIPPPPP------------FPGGPG 737
Query: 336 PPPPPPLPSTGPPPP-----PPPPPLPNQVPP 362
PPPPP PPPP P P LP + P
Sbjct: 738 IPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTP 769
Score = 35.0 bits (79), Expect = 0.19
Identities = 15/49 (30%), Positives = 30/49 (61%)
Query: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Q KE ++ R E+M R +L +E+ E+ERLE+++ ++ ++ + E
Sbjct: 1147 QAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDE 1195
Score = 32.7 bits (73), Expect = 0.96
Identities = 15/40 (37%), Positives = 32/40 (80%), Gaps = 2/40 (5%)
Query: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERL 186
++E Q+++E E E++ R ++ +E+ E+ERLE+++ +RE+L
Sbjct: 1149 VKENQKRRETE-EKMRRAKLAKEKAEKERLEKQQ-KREQL 1186
Score = 31.6 bits (70), Expect = 2.1
Identities = 13/34 (38%), Positives = 28/34 (82%), Gaps = 1/34 (2%)
Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERL 176
+RR+ +E+ R+ +L +E+ E+ER+E+++ +RE+L
Sbjct: 1154 KRRETEEKMRRAKLAKEKAEKERLEKQQ-KREQL 1186
Score = 31.2 bits (69), Expect = 2.8
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 20/149 (13%)
Query: 112 NSQETGPTLPRQNSQLPAQVQNGPS---QEELEIQRRQLQEQQRQKELERERLERERMER 168
N Q+ + +Q S + VQN P+ +++ +++ + Q++ + R+ ME
Sbjct: 1054 NLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMET 1113
Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
L +E E + ++L E+ + L + Q E Q+R +E
Sbjct: 1114 --LYKELGEYFLFDPKKLSVEEFFMD---------LHNFRNMFLQAVKENQKR-----RE 1157
Query: 229 RQERERLERLERERQERER-QEQLEREQL 256
+E+ R +L +E+ E+ER ++Q +REQL
Sbjct: 1158 TEEKMRRAKLAKEKAEKERLEKQQKREQL 1186
>gi|18426913 drebrin 1 isoform b [Homo sapiens]
Length = 651
Score = 93.2 bits (230), Expect = 6e-19
Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)
Query: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
+S ++H L + N++ G T + ++ + E I R Q EQ +++E
Sbjct: 143 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 192
Query: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
R+ ER++ ER R E+ER+E+ER E+E E+ ERE+Q E + + + E E + R
Sbjct: 193 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 252
Query: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
L+ Q R E +E +++ E E +E Q + ++ER S++A
Sbjct: 253 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 311
Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
V +P N G S + P +PS P+A L + P
Sbjct: 312 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 366
Query: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
PP PPPPPP T P P P P + PP PP P PA
Sbjct: 367 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 426
Query: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
+E + A A A ++ + +T + + N +A+S D GNG
Sbjct: 427 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 486
Query: 437 LPLGGSGLMEEMSA 450
G S L E A
Sbjct: 487 ---GASTLQGEPRA 497
>gi|18426915 drebrin 1 isoform a [Homo sapiens]
Length = 649
Score = 93.2 bits (230), Expect = 6e-19
Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 43/374 (11%)
Query: 101 ASAMMHALEVL---NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELE 157
+S ++H L + N++ G T + ++ + E I R Q EQ +++E
Sbjct: 141 SSPVLHRLRLREDENAEPVGTTYQKTDAAV----------EMKRINREQFWEQAKKEEEL 190
Query: 158 RERLERERM--ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQER 215
R+ ER++ ER R E+ER+E+ER E+E E+ ERE+Q E + + + E E + R
Sbjct: 191 RKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRR 250
Query: 216 LERQERLDRERQERQERERLERLERERQERE---RQEQLEREQLEWERERRISSAAAPAS 272
L+ Q R E +E +++ E E +E Q + ++ER S++A
Sbjct: 251 LKEQSIFGDHRDE-EEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCD 309
Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
V +P N G S + P +PS P+A L + P
Sbjct: 310 VPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERAL-----DEVTSSQP 364
Query: 333 PPGPPPPPPLPSTGPPPP-----------PPPPPLPNQVPPPPPPPP-APPLPASGFFLA 380
PP PPPPPP T P P P P + PP PP P PA
Sbjct: 365 PPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFM 424
Query: 381 SMSEDNRPLTGLAAAIAGA-KLRKVSRMEDTSFPSGGNAIGVN---SASSKTDTGRGNGP 436
+E + A A A ++ + +T + + N +A+S D GNG
Sbjct: 425 ESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGE 484
Query: 437 LPLGGSGLMEEMSA 450
G S L E A
Sbjct: 485 ---GASTLQGEPRA 495
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 92.0 bits (227), Expect = 1e-18
Identities = 76/250 (30%), Positives = 116/250 (46%), Gaps = 29/250 (11%)
Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
E E + ER+E L + Q+ E E + + LE+Q ++R + LD R+
Sbjct: 383 EDAETKNAALERVEELEENISHLSEKLQDTEN-EAMSKIVELEKQ-LMQRNKELDVVREI 440
Query: 229 RQERER----LERLERERQER-ERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
++ L ++ +E++E +RQ LE++ E E++ I + + V+
Sbjct: 441 YKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIK-IQKKGDGDIAILPVVAS 499
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGP-----AQASVALPPPPGPPP 338
+ S G + + + P+ GPL PPPPPPLPP Q PP P PPP
Sbjct: 500 GTLSM-GSEVVAGNSVGPTMGAASSGPL-PPPPPPLPPSSDTPETVQNGPVTPPMPPPPP 557
Query: 339 PPPLPSTGPPPPPPPPPLPNQVPPP-----PPPPPAPPLPASGFFLASMSEDNRPLTGLA 393
PPP PPPPPPPPP P +P P P PP APPLP++ + + P
Sbjct: 558 PPP----PPPPPPPPPP-PPPLPGPAAETVPAPPLAPPLPSA----PPLPGTSSPTVVFN 608
Query: 394 AAIAGAKLRK 403
+ +A K++K
Sbjct: 609 SGLAAVKIKK 618
Score = 32.0 bits (71), Expect = 1.6
Identities = 16/60 (26%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 189 EQLERERQERERQERLERQERLERQERLERQE-RLDRERQERQERERLERLERERQERER 247
+Q E E + R++QE+ ++ LE++ +E+Q+ + + +RQ++E + L R + + R
Sbjct: 982 KQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNR 1041
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 92.0 bits (227), Expect = 1e-18
Identities = 121/482 (25%), Positives = 204/482 (42%), Gaps = 97/482 (20%)
Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
L Q +N + E L+ Q++QLQ+QQ RQ+ +E ++ ER R+E E+
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413
Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
RER +R+ E+E RLE Q R +ER + ER + +R + +E+ + ERL +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470
Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
QE L+ L++++Q+++ Q+Q +++ L +R+ R ++ A PA +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
+ P A S+P T P PP+P QAS P PPGP PP
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568
Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
P P + ++VP P P P S S ++P LAA A
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615
Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
S D + P + +A G + T G GP P + + + A ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668
Query: 459 AEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPR 518
++ S+I T S P + +S + WER++++ + + + S
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLE 728
Query: 519 KNQIVFDNRSYDSLHRPKSTPLSQPS---------------ANGVQTEGLDYDRLKQDIL 563
+N++ + +P S+P+ P A+ + G D+ LK+ L
Sbjct: 729 RNRVGVSS-------KPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTL 781
Query: 564 DE 565
DE
Sbjct: 782 DE 783
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 92.0 bits (227), Expect = 1e-18
Identities = 119/474 (25%), Positives = 201/474 (42%), Gaps = 89/474 (18%)
Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
L Q +N + E L+ Q++QLQ+QQ RQ+ +E ++ ER R+E E+
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413
Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
RER +R+ E+E RLE Q R +ER + ER + +R + +E+ + ERL +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470
Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
QE L+ L++++Q+++ Q+Q +++ L +R+ R ++ A PA +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
+ P A S+P T P PP+P QAS P PPGP PP
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568
Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
P P + ++VP P P P S S ++P LAA A
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615
Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
S D + P + +A G + T G GP P + + + A ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668
Query: 459 AEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPR 518
++ S+I T S P + +S + WER++++ + + + S
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGHLPQAGSLE 728
Query: 519 KNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTE-------GLDYDRLKQDILDE 565
+N++ + +P S+P+ P + D+ LK+ LDE
Sbjct: 729 RNRVGVSS-------KPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDE 775
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 89.7 bits (221), Expect = 7e-18
Identities = 55/130 (42%), Positives = 79/130 (60%), Gaps = 5/130 (3%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER-LERERLEQEQLERE 194
++ E E +R+ +E+ RQ++ ERER ++ ERER ER++ ERER +R
Sbjct: 218 TETETERKRQTDRERDRQRKTERER--EKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 195 RQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLER 253
++ERERQ +RQ R ER ER+ RER+ +ER R ERER+ ERERQ + ER
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335
Query: 254 EQLEWERERR 263
++ E ERER+
Sbjct: 336 DR-EKERERK 344
Score = 89.4 bits (220), Expect = 9e-18
Identities = 58/133 (43%), Positives = 86/133 (64%), Gaps = 11/133 (8%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Q + E R++ E++R+K+ ERER ER++ ERER ER+R +R+R ++ Q ERERQ
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDK-ERER-ERDR-DRDR-DRRQKERERQ 282
Query: 197 -ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ---ERERQEQLE 252
+R+RQ R ER ER+ +R+ +RER ++ERER ERERQ ER+R+++ E
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERE 342
Query: 253 RE---QLEWERER 262
R+ Q E +RER
Sbjct: 343 RKRKRQTEMDRER 355
Score = 88.2 bits (217), Expect = 2e-17
Identities = 56/121 (46%), Positives = 78/121 (64%), Gaps = 5/121 (4%)
Query: 145 RQLQEQQRQKELERER-LERERMERERLERERLERERLERERLEQEQLERERQ-ERERQE 202
R+ +E++RQ + +R+R ER+R + ER+R ERER ERER + + ERER+ ERERQ
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQR-ERER-ERERNRKRERERERERERERQR 331
Query: 203 RLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLEREQLEWERE 261
ER ER+ + +RQ +DRER + RE + ERER+ ERER Q RE+ E ER+
Sbjct: 332 ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD 391
Query: 262 R 262
R
Sbjct: 392 R 392
Score = 86.7 bits (213), Expect = 6e-17
Identities = 53/155 (34%), Positives = 85/155 (54%), Gaps = 5/155 (3%)
Query: 112 NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER- 170
N QE ++ + + ++ E E +R E +R+++ +RER + + ERER
Sbjct: 184 NRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERERE 243
Query: 171 --LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
ERER ER++ + + +R+R RQ+ ERQ +RQ R ER +R+R+
Sbjct: 244 KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER 303
Query: 229 RQERERLERLERERQERERQEQLERE-QLEWERER 262
++ERER ER ++ERER+ + ERE Q E ER+R
Sbjct: 304 QRERER-ERERNRKRERERERERERERQRETERDR 337
Score = 84.0 bits (206), Expect = 4e-16
Identities = 45/131 (34%), Positives = 75/131 (57%), Gaps = 4/131 (3%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Q + E +R + +++RQ++ ER R + E+ R ER ER+R + + E ER R+
Sbjct: 152 QRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRE 211
Query: 197 -ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER---QERERQEQLE 252
ERER+ E + + + +RQ + +RER+++ ERER E ER +ERER +
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271
Query: 253 REQLEWERERR 263
R++ + ERER+
Sbjct: 272 RDRRQKERERQ 282
Score = 82.8 bits (203), Expect = 8e-16
Identities = 49/129 (37%), Positives = 76/129 (58%), Gaps = 5/129 (3%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER-LERERLEQEQLERER 195
+ E + R++ + +R +E ER+R + ERER + ERER ERER Q + ER+R
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDR 337
Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
+ ERER+ + + + ER + R+ R ER+ +ERER + RER+ERER +R+
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQ 397
Query: 255 QLEWERERR 263
+ ERER+
Sbjct: 398 K---ERERQ 403
Score = 80.9 bits (198), Expect = 3e-15
Identities = 50/126 (39%), Positives = 75/126 (59%), Gaps = 8/126 (6%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLE------RERLERERLERERLEQEQ 190
+ E E +R++ E+ R+KE ER+R + M+RER R + ERER ERER Q
Sbjct: 322 ERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER-ERERERDRQ 380
Query: 191 LERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER-QERERQE 249
RER+ERER +RQ+ ERQ +R + + E+Q +E++R RER +ERE+Q+
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK 440
Query: 250 QLEREQ 255
ER++
Sbjct: 441 GRERDR 446
Score = 80.5 bits (197), Expect = 4e-15
Identities = 52/134 (38%), Positives = 75/134 (55%), Gaps = 9/134 (6%)
Query: 139 ELEIQRRQLQEQQRQKELERERLERERMERER---LERERLERERLERERLEQEQLERER 195
E E +R+ +E+ RQ+E ER R + E ER R+R + ERER + ERER
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161
Query: 196 Q-ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
Q +RERQ + ER + ER+ RQER +RERQ +E + +R +ERER+ + E E
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETE 221
Query: 255 -----QLEWERERR 263
Q + ER+R+
Sbjct: 222 TERKRQTDRERDRQ 235
Score = 79.7 bits (195), Expect = 7e-15
Identities = 54/133 (40%), Positives = 85/133 (63%), Gaps = 11/133 (8%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
++ + E +R++ E+QR++E ERER + ERER ERER + ER+R ++ + +R+R
Sbjct: 291 TERDRETERKR--ERQRERERERERNRKRERERER-ERERERQRETERDREKERERKRKR 347
Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLER-LERERQ-ERERQEQ 250
Q +RER + R+ R RQ ER+ +R+RQ +ERE ER +R+RQ ERERQ +
Sbjct: 348 QTEMDRERNRQTGREGR--RQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405
Query: 251 LERE-QLEWERER 262
+R+ Q E E++R
Sbjct: 406 KDRDGQRETEKQR 418
Score = 79.3 bits (194), Expect = 9e-15
Identities = 56/146 (38%), Positives = 84/146 (57%), Gaps = 24/146 (16%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERL----------------ERERLERER 180
+ + + +R++ E+ RQKE ERE+ +ER ERER ERER
Sbjct: 160 ERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETE 219
Query: 181 LERERLEQEQLERERQ---ERERQERLERQERLERQERLERQERLDRERQERQERERLER 237
E ER Q ER+RQ ERER+++ ER+ ER+ ER + +RER ++R+R ++
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERET--ERDKERERERDRDRDRDRRQK 277
Query: 238 LERERQ-ERERQEQLEREQLEWERER 262
ERERQ +R+RQ + ER++ E ER+R
Sbjct: 278 -ERERQTDRKRQRRTERDR-ETERKR 301
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/142 (36%), Positives = 76/142 (53%), Gaps = 11/142 (7%)
Query: 133 NGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERERLEQE 189
+G +E + R+ + ++RQ E E +R R E++R + RER E+ER Q
Sbjct: 50 DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109
Query: 190 QLERERQ-ERERQERLERQERLERQERLERQERLD----RERQERQERERLERLERERQ- 243
ER+RQ E+ER + ER+ ER+ R + D RERQ E+ER + +RERQ
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 244 --ERERQEQLEREQLEWERERR 263
ER RQ++ ERE+ ER R
Sbjct: 170 QTERNRQKEREREKNRQERRER 191
Score = 75.9 bits (185), Expect = 1e-13
Identities = 50/148 (33%), Positives = 77/148 (52%), Gaps = 7/148 (4%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER- 180
R+ + + +N + E E +R + + RQ + +RER + E+ER + ER+R
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 181 LERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLER 240
ER R ++ + E+ RQER +ER +E ER +RER+ E ER + +R
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230
Query: 241 ERQ-----ERERQEQLEREQL-EWERER 262
ER ERER++Q ERE+ E E ER
Sbjct: 231 ERDRQRKTEREREKQAERERASERETER 258
Score = 75.5 bits (184), Expect = 1e-13
Identities = 52/132 (39%), Positives = 74/132 (56%), Gaps = 11/132 (8%)
Query: 141 EIQRRQLQEQQRQKELERERL-ERERMERERLERERLERERLERERLEQEQLERERQ--- 196
E QR + +E++RQ + ER+R E+ER ++ ERE R+R Q ERERQ
Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155
Query: 197 --ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254
ERERQ ERQ + ER + ER+ ++ RQER+ERER E + ++R + ERE
Sbjct: 156 EKERERQTDRERQRQTERNRQKERER--EKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 255 ---QLEWERERR 263
+ E E ER+
Sbjct: 214 RERETETETERK 225
Score = 75.5 bits (184), Expect = 1e-13
Identities = 50/128 (39%), Positives = 78/128 (60%), Gaps = 5/128 (3%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERER-LERERLERERLERERLEQEQLERER 195
Q E E +R + ++++R++E ERER + ER+R ERER + + E +R Q RE
Sbjct: 304 QRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREG 363
Query: 196 QERERQERLERQERLERQERLERQER-LDRERQERQERERLERLERERQERERQEQLERE 254
+ + +ER ER+ +RQ ER+ER DR+R ++ERER +R+ Q RE ++Q ERE
Sbjct: 364 RRQAERER-ERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ-RETEKQRERE 421
Query: 255 QLEWERER 262
+ + E ER
Sbjct: 422 K-DRESER 428
Score = 75.1 bits (183), Expect = 2e-13
Identities = 49/132 (37%), Positives = 80/132 (60%), Gaps = 7/132 (5%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERER-LERERLERERLERERLEQEQLERER 195
+ E + R++ + ++RQ++ E+ER + ER+R E+ER ++ ERE + + R+R
Sbjct: 82 RREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERE--RLERLERERQERERQEQ 250
Q +RER+ + + ++ ERQ ERQ + +R RQ+ +ERE R ER ERERQ RE++ +
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ-REKENK 200
Query: 251 LEREQLEWERER 262
E E RER
Sbjct: 201 TEDRHSERGRER 212
Score = 75.1 bits (183), Expect = 2e-13
Identities = 58/132 (43%), Positives = 82/132 (62%), Gaps = 9/132 (6%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
++ + E QR + +E++R ++ ERER ERER ERER +RE+ ERER + Q E +R
Sbjct: 297 TERKRERQRERERERERNRKRERER-ERER-ERERQRETERDREK-ERERKRKRQTEMDR 353
Query: 196 QERERQERLE--RQERLERQERLERQERLDRERQERQ-ERERLERLERERQ-ERERQEQL 251
ER RQ E RQ ER+ ER + RER+ER+ +R+R + ERERQ E++R Q
Sbjct: 354 -ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 252 ERE-QLEWERER 262
E E Q E E++R
Sbjct: 413 ETEKQREREKDR 424
Score = 74.7 bits (182), Expect = 2e-13
Identities = 54/143 (37%), Positives = 79/143 (55%), Gaps = 17/143 (11%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER---LERERLEQEQLER 193
Q + E R++ +E+ RQKE ERE R+R + ERER E+ER Q ER
Sbjct: 108 QTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER 167
Query: 194 ERQ-----ERERQERLERQERLERQERLERQERL-----DRERQERQERERLERLERERQ 243
+RQ ++ER+ RQER ER+ + E++ + +R R+ +ERE ER+RQ
Sbjct: 168 QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQ 227
Query: 244 ---ERERQEQLERE-QLEWERER 262
ER+RQ + ERE + + ERER
Sbjct: 228 TDRERDRQRKTEREREKQAERER 250
Score = 74.3 bits (181), Expect = 3e-13
Identities = 44/128 (34%), Positives = 73/128 (57%), Gaps = 6/128 (4%)
Query: 143 QRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE----- 197
+RR+ +++ R+++ RER ERER +R+R E+ER Q++ ERE +
Sbjct: 80 ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETEREGERG 138
Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLE 257
R+RQ +R+ +R ER+ + DRERQ + ER R + ERE+ +ER+E+ + + E
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198
Query: 258 WERERRIS 265
+ E R S
Sbjct: 199 NKTEDRHS 206
Score = 71.2 bits (173), Expect = 2e-12
Identities = 48/135 (35%), Positives = 78/135 (57%), Gaps = 10/135 (7%)
Query: 136 SQEELEIQRRQLQEQQRQKELER-ERLERERMERERLERERLERER---LERERLEQEQL 191
+ E + Q + ++++R++E R ER ERER + + E ER ERER + +
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222
Query: 192 ERERQ---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ 248
ER+RQ ER+RQ + ER+ E+Q ER + ER + +ERER +R+R+++ER+
Sbjct: 223 ERKRQTDRERDRQRKTERER--EKQAERERASERETERDKERERERDRDRDRDRRQKERE 280
Query: 249 EQLERE-QLEWERER 262
Q +R+ Q ER+R
Sbjct: 281 RQTDRKRQRRTERDR 295
Score = 67.0 bits (162), Expect = 5e-11
Identities = 55/173 (31%), Positives = 82/173 (47%), Gaps = 15/173 (8%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER 195
++ + E R+ +E +RQ E ERER ERER + ERE ER+R Q ERER
Sbjct: 349 TEMDRERNRQTGREGRRQAERERER------ERERDRQSAREREERERDRDRDRQKERER 402
Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQL 251
Q +R+ Q E+Q E+ ER RER++++ RER +RERQ +R+ Q
Sbjct: 403 QTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER----DRERQTDRQAGRQR 458
Query: 252 EREQLEWERERRIS-SAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQ 303
+R L R + S + P + SS +P + P P++
Sbjct: 459 KRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAK 511
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 15/132 (11%)
Query: 140 LEIQRRQ--LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER-Q 196
L+ RR+ QE R++ L + + + +RER ++ ER R E+ Q ERE +
Sbjct: 24 LDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRR------EKRQTERETDR 77
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQEQLERE- 254
+RER+ +R + +R +R +RERQ +ER+R ER RQ ERER+ + E E
Sbjct: 78 KRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER 137
Query: 255 ----QLEWERER 262
Q + +RER
Sbjct: 138 GRDRQTDGQRER 149
Score = 40.0 bits (92), Expect = 0.006
Identities = 23/82 (28%), Positives = 49/82 (59%), Gaps = 2/82 (2%)
Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
Q+ +EE E R + ++++R+++ E++R + E++R ERE+ RER + +
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQR-EREKDRESERGRERGREREK 438
Query: 192 ERERQERERQERLERQERLERQ 213
++ R ER+R+ + +RQ +R+
Sbjct: 439 QKGR-ERDRERQTDRQAGRQRK 459
>gi|21071077 dishevelled-associated activator of morphogenesis 1
[Homo sapiens]
Length = 1078
Score = 89.7 bits (221), Expect = 7e-18
Identities = 60/177 (33%), Positives = 82/177 (46%), Gaps = 35/177 (19%)
Query: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLE 252
+E+ E+ R+E E Q++LE++ER + ++E + + E+LE+E E ++ +Q
Sbjct: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV 508
Query: 253 RE---QLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLG 309
+ QL E RR A+ P PG P+ P
Sbjct: 509 ADLTAQLH-ELSRRAVCASIPGG--------------PSPGAPGGPFPSSVPGSL----- 548
Query: 310 PLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366
L PPPPPPLP G PPPPPPLP GPPPPP PPPL +PPP P
Sbjct: 549 -LPPPPPPPLPGGML-----------PPPPPPLPPGGPPPPPGPPPLGAIMPPPGAP 593
Score = 32.3 bits (72), Expect = 1.3
Identities = 21/92 (22%), Positives = 46/92 (50%), Gaps = 12/92 (13%)
Query: 201 QERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQ-----------E 249
+ + E + +++E ER+ R++ + +E++ERER R +E E + E
Sbjct: 985 EAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGE 1044
Query: 250 QLEREQLEWERER-RISSAAAPASVETPLNSV 280
+++ + +R R RI++ +S E P+ +
Sbjct: 1045 VFDKDLSKLKRNRKRITNQMTDSSRERPITKL 1076
Score = 30.0 bits (66), Expect = 6.2
Identities = 17/69 (24%), Positives = 37/69 (53%), Gaps = 3/69 (4%)
Query: 138 EELEIQRRQLQEQQRQKELE---RERLERERMERERLERERLERERLERERLEQEQLERE 194
E++ + +LQ++ +KE E + + + E M+ +E+LE+E E ++++Q+ +
Sbjct: 453 EKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLT 512
Query: 195 RQERERQER 203
Q E R
Sbjct: 513 AQLHELSRR 521
Score = 29.6 bits (65), Expect = 8.1
Identities = 16/59 (27%), Positives = 36/59 (61%), Gaps = 1/59 (1%)
Query: 137 QEELEIQRRQLQE-QQRQKELERERLERERMERERLERERLERERLERERLEQEQLERE 194
+E+ E R++ E QQ+ ++ ERE + + + E ++ +E+LE+E E +Q++++
Sbjct: 449 KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQ 507
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 89.4 bits (220), Expect = 9e-18
Identities = 48/128 (37%), Positives = 89/128 (69%), Gaps = 2/128 (1%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+EE E ++R+ +++ ++ E + +R ++E+ ER R +E ERER E ER +E+ ERER+
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE-ERKREERKERERK 150
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER-QERERQEQLEREQ 255
+ ER++ ER+ER +R+ + ++ +R+ +ER+ER++ ER +ER +ERER+E+ ER++
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210
Query: 256 LEWERERR 263
++E R
Sbjct: 211 ERKKKEER 218
Score = 88.6 bits (218), Expect = 1e-17
Identities = 47/118 (39%), Positives = 86/118 (72%), Gaps = 4/118 (3%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL---ERERLEQEQLE 192
S+E E +R++ ++++ +KE ER++ ERE+ ERER ER++ ER+++ E ER E+E+ E
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKEEERKEKERKE 185
Query: 193 RERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQ 250
R+++ER R+ER + +ER ER+ER + +++ + ++ERQ+ + E+ER +RER+E+
Sbjct: 186 RKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 87.0 bits (214), Expect = 4e-17
Identities = 52/143 (36%), Positives = 96/143 (67%), Gaps = 17/143 (11%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERM-ERERLERERLER-------------ERL 181
S+ + E + R+ ++++R+KE +RER ++E+ ER++ ERER +R +R
Sbjct: 57 SERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRK 116
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLE--RLE 239
++E+ E+ + +E +ERER+E +R+ER ER+ + E +E+ +RER+ER++RER + E
Sbjct: 117 KKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKE 175
Query: 240 RERQERERQEQLEREQLEWERER 262
ER+E+ER+E+ +RE+ ER++
Sbjct: 176 EERKEKERKERKKRERNRKERKK 198
Score = 86.3 bits (212), Expect = 7e-17
Identities = 51/133 (38%), Positives = 96/133 (72%), Gaps = 9/133 (6%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERL-EQEQLERER 195
+ E EI+ R+ +++R+ E ++ER ERE+ +RER E+ER +RER ++E+ E+++ ERER
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKRER-EKER-KRERGKKEKKGERKKEERER 97
Query: 196 QERERQERLERQERLERQERLERQER-----LDRERQERQERERLERLERERQERERQEQ 250
++R R++ + E E++++ E++ER +ER+ ++ER+R ER ERER++ ER+++
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKE 157
Query: 251 LEREQLEWERERR 263
ER++ + +RER+
Sbjct: 158 RERKERK-KRERK 169
Score = 85.1 bits (209), Expect = 2e-16
Identities = 59/165 (35%), Positives = 99/165 (60%), Gaps = 33/165 (20%)
Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERL----------ERERMERERLER-------- 173
+ G + E E ++ + + ++R++E E+ER ER++ ERER +R
Sbjct: 49 KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108
Query: 174 -----ERLERERLERERLEQEQLERER-QERERQERLERQ-ERLERQERLERQERLDRER 226
+R ++E+ ER R +E ERER +ER+R+ER ER+ ++ ER++ ER+ER RER
Sbjct: 109 GEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER 168
Query: 227 -------QERQERERLERLERERQERERQEQLER-EQLEWERERR 263
+ER+E+ER ER +RER +ER+++ ER E+ E ++ER+
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213
Score = 85.1 bits (209), Expect = 2e-16
Identities = 48/127 (37%), Positives = 88/127 (69%), Gaps = 6/127 (4%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+E+ E R + ++R+++ ER+R ER+ ER++ ERE+ ERER ER++ E++Q+ + +
Sbjct: 118 KEKKERGRTSKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRERKQVGEKEE 176
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
ER+ +ER ER++R ER ++ + +RER+ER+ER++ ER ++E +++ERQ+ +
Sbjct: 177 ERKEKERKERKKR----ERNRKERKKERERKERRERKK-ERKKKEERKKERQKDRQTNWR 231
Query: 257 EWERERR 263
E ER +R
Sbjct: 232 EKERGKR 238
Score = 65.9 bits (159), Expect = 1e-10
Identities = 38/95 (40%), Positives = 67/95 (70%), Gaps = 4/95 (4%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
++E E + R+ +E+++ E E ER E+ER ER++ ER R ER++ ERER E+ + ++ER+
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK-ERERKERRERKKERK 213
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQE 231
++E +++ ERQ+ +RQ +ER RER+ER++
Sbjct: 214 KKEERKK-ERQK--DRQTNWREKERGKRERKERKK 245
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/93 (26%), Positives = 59/93 (63%), Gaps = 4/93 (4%)
Query: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
RER +E ++ + ER+++ RER++R +E+ ++ER +++++ +R+++ER+ +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 233 ERLERLERERQERERQEQLEREQLEWERERRIS 265
+R RE++ +E +E+ +R++ E + R S
Sbjct: 99 KR----RREKENKEGEEKEKRKKKEKKERGRTS 127
Score = 47.4 bits (111), Expect = 4e-05
Identities = 27/75 (36%), Positives = 48/75 (64%), Gaps = 4/75 (5%)
Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
Q G +EE + + R+ ++++ + ER++ ERER ER ++ER ++E ++ER + Q
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKK-ERERKERRERKKERKKKEERKKERQKDRQT 228
Query: 192 ---ERERQERERQER 203
E+ER +RER+ER
Sbjct: 229 NWREKERGKRERKER 243
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 7/87 (8%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ Q+ + + +E E ++R+ ++R+K ERER ER ++ER ++E
Sbjct: 166 RERKQVGEKEEERKEKERKERKKRERNRKERKK-------ERERKERRERKKERKKKEER 218
Query: 182 ERERLEQEQLERERQERERQERLERQE 208
++ER + Q +ER ++ER ER++
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 88.6 bits (218), Expect = 1e-17
Identities = 120/476 (25%), Positives = 199/476 (41%), Gaps = 97/476 (20%)
Query: 127 LPAQVQNGPSQEELEIQRRQLQEQQ--------------RQKELERERLERERMERERLE 172
L Q +N + E L+ Q++QLQ+QQ RQ+ +E ++ ER R+E E+
Sbjct: 356 LRLQQENKSNSEALK-QQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVE-EQQR 413
Query: 173 RERLERERLERE---RLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQER 229
RER +R+ E+E RLE Q R +ER + ER + +R + +E+ + ERL +RQ +
Sbjct: 414 REREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ-RQSERL--QRQLQ 470
Query: 230 QERERLERLERERQERERQEQLEREQLEWERE------RRISSAAAPASVETPLNSVLGD 283
QE L+ L++++Q+++ Q+Q +++ L +R+ R ++ A PA +
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMN 530
Query: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGP--PPPPP 341
+ P A S+P T P PP+P QAS P PPGP PP
Sbjct: 531 KQQNSP--LAKSKPGST-------------GPEPPIP----QAS---PGPPGPLSQTPPM 568
Query: 342 LPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKL 401
P P + ++VP P P P S S ++P LAA A
Sbjct: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVP---------RSQSLQDQPTRNLAAFPA---- 615
Query: 402 RKVSRMEDTSFP---SGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRI 458
S D + P + +A G + T G GP P + + + A ++
Sbjct: 616 ---SHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA----PPKV 668
Query: 459 AEKGSTIETEQKEDKGEDSEPVTS----------------KASSTSTPEPTRKPWERTNT 502
++ S+I T S P + + + TP+P P +
Sbjct: 669 PQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGP 728
Query: 503 MNGSKSPVISRRDS--PRKNQIVFDNRSY----DSLHRPKSTPLSQPSANGVQTEG 552
N S +P + R D R + ++ + + SL R + S+P ++ V + G
Sbjct: 729 PNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPG 784
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 88.2 bits (217), Expect = 2e-17
Identities = 44/131 (33%), Positives = 98/131 (74%), Gaps = 4/131 (3%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLER-ERLERERLEQEQLERE 194
+Q E E ++ + + ++R++E E+ER +RER ++E+ +R++ ER + ER+R E+E+ +E
Sbjct: 30 TQRESERKKERREREKRKREREKER-KRERGKKEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 195 RQERERQERLERQERLERQE--RLERQERLDRERQERQERERLERLERERQERERQEQLE 252
R+E+ER++R + +++ ER++ R ER+++ +R+ +ER+ ++R ER ++R++++R+++ +
Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 253 REQLEWERERR 263
RE+ +RER+
Sbjct: 149 REKERGKRERK 159
Score = 87.8 bits (216), Expect = 3e-17
Identities = 43/130 (33%), Positives = 95/130 (73%), Gaps = 4/130 (3%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERER---LERERLERERLEQEQLER 193
+ E + +RR+ ++++R++E ER+R ++ +++R +RER ER+R ERE+ +E+ E+
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
ER++R+++++ +++ R+ER +++ER +RER+ +Q RER +R +R +++R ++ + E+
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRER-KRKKRRKKKRRKERKREK 151
Query: 254 EQLEWERERR 263
E+ + ER+R+
Sbjct: 152 ERGKRERKRK 161
Score = 86.7 bits (213), Expect = 6e-17
Identities = 45/131 (34%), Positives = 98/131 (74%), Gaps = 4/131 (3%)
Query: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLER-ERLERERLERERLEQEQLERE 194
S+ + E + R+ ++++R+KE +RER ++E+ +R++ ER + ER+R ERE+ +E+ E+E
Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 195 RQERERQERLERQERLERQERLERQERLDRERQ--ERQERERLERLERERQERERQEQLE 252
R++R+++++ +++ R+ER +++ER +RER+ +R+ER+R +R +++R+ +ER+ + E
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRR-KERKREKE 152
Query: 253 REQLEWERERR 263
R + E +R++R
Sbjct: 153 RGKRERKRKKR 163
Score = 85.5 bits (210), Expect = 1e-16
Identities = 42/143 (29%), Positives = 93/143 (65%), Gaps = 2/143 (1%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLER--E 179
R+ + + + +E + ++++ ++++R KE ER+R ERE+ +ER E+ER +R E
Sbjct: 41 REREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKE 100
Query: 180 RLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLE 239
+ +RER ++ + ER++++ ++ E ++R ER+ + R+++ +ER+ +ER + ER
Sbjct: 101 KKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKR 160
Query: 240 RERQERERQEQLEREQLEWERER 262
++R++ ER+++ ER + E ++ER
Sbjct: 161 KKRKKEEREKKRERNRKERKKER 183
Score = 84.3 bits (207), Expect = 3e-16
Identities = 49/131 (37%), Positives = 97/131 (74%), Gaps = 8/131 (6%)
Query: 138 EELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
+E E +R++ ++Q++++ E ER + ++E+ +RER +R R ER++ ++ER E+E+ ++R+
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKK-KKERKERERENKQRR 131
Query: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER----ERQEQLE 252
ER+R++R +++ R ER+ ER +R +R+R++R++ ER ++ ER R+ER ER+E+ E
Sbjct: 132 ERKRKKRRKKKRRKERKREKERGKR-ERKRKKRKKEEREKKRERNRKERKKERERKERRE 190
Query: 253 REQLEWERERR 263
R++ E ++ERR
Sbjct: 191 RKK-ERKKERR 200
Score = 82.0 bits (201), Expect = 1e-15
Identities = 47/153 (30%), Positives = 97/153 (63%), Gaps = 9/153 (5%)
Query: 137 QEELEIQRRQLQEQQRQK----ELERERLERERMER----ERLERERLERERLERERLEQ 188
++E E QR++ +E++R+K + +RER +R R ER ER ERER ++R ER+R ++
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 189 EQLERERQERERQERLERQERLERQERLERQERLDRERQER-QERERLERLERERQERER 247
+ +R ++ + +ER +R+ + +++++ ER+++ +R R+ER +ERER ER ER+++ ++
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
Query: 248 QEQLEREQLEWERERRISSAAAPASVETPLNSV 280
+ + + + + + +R+ S E+ N V
Sbjct: 199 RRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231
Score = 74.3 bits (181), Expect = 3e-13
Identities = 40/146 (27%), Positives = 93/146 (63%), Gaps = 5/146 (3%)
Query: 114 QETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLER 173
+E G R+ + Q + +E + ++ + + +++Q+ + ++ER ERER +
Sbjct: 69 RERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128
Query: 174 ERLERERLER---ERLEQEQLERERQERER-QERLERQERLERQERLERQERLDRERQER 229
+R ER+R +R +R ++ + E+ER +RER +++ +++ER +++ER ++ + +RER+ER
Sbjct: 129 QRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKER 188
Query: 230 QERERLERLE-RERQERERQEQLERE 254
+ER++ + E R+++ER++ + +R+
Sbjct: 189 RERKKERKKERRKKKERKKDRKTDRQ 214
Score = 50.4 bits (119), Expect = 4e-06
Identities = 26/83 (31%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Query: 182 ERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLER-LER 240
E + + + + +RE + + ER+ER +R+ E++ + +R ++E+++R++ ER ER
Sbjct: 16 ELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER 75
Query: 241 ERQERERQEQLEREQLEWERERR 263
ER+ +ER++Q +E+ E ER +R
Sbjct: 76 ERKRKEREKQ-RKERREKERRKR 97
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 87.4 bits (215), Expect = 3e-17
Identities = 57/134 (42%), Positives = 84/134 (62%), Gaps = 17/134 (12%)
Query: 145 RQLQEQQRQKELERERLERERMERER---LERERLERER---LERERLEQEQLERERQ-- 196
++L+E++ +KE ER+ +E+ER ERER ERER ERER ERER ++++ ERER+
Sbjct: 289 KKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERD 348
Query: 197 -------ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ-ERERQ 248
ER+R ER +R+ +R + R R++ ++RER ERER+ ERER+
Sbjct: 349 RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE 408
Query: 249 EQLEREQLEWERER 262
+ ERE+ E ERER
Sbjct: 409 RERERER-ERERER 421
Score = 85.1 bits (209), Expect = 2e-16
Identities = 56/137 (40%), Positives = 82/137 (59%), Gaps = 9/137 (6%)
Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERER---MERERLERERLERERLERERLEQ 188
+ G ++E + ++ +E++R++E ERER ERER ERER + + ERER ER+R
Sbjct: 294 EKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERER-ERDRDRD 352
Query: 189 EQLERER---QERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
ER+R +ER+R ER + R++ DRER+ +ERER ERER ER
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER-ER 411
Query: 246 ERQEQLEREQLEWERER 262
ER+ + ERE+ E ERE+
Sbjct: 412 ERERERERER-EREREK 427
Score = 75.1 bits (183), Expect = 2e-13
Identities = 50/146 (34%), Positives = 83/146 (56%), Gaps = 26/146 (17%)
Query: 139 ELEIQRRQLQEQQRQKELE-RERLERERMERERLERERLERERLERERLEQEQLERERQE 197
E+E +R L ++ K + ++LE E+ ++E+ ER+ +E+ER ERER + + ERER+E
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERER--ERERERERRE 324
Query: 198 RERQERLERQERLERQERLERQERLDRERQERQERERLERLERER--------------- 242
RER+ ER+ E++ ER+ DR+R + ++R+R +R+R
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
Query: 243 ------QERERQEQLEREQLEWERER 262
+ERER+ + ERE+ E ERER
Sbjct: 385 REKSRDRERERERERERER-ERERER 409
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/127 (33%), Positives = 74/127 (58%), Gaps = 2/127 (1%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERER-MERERLERERLERERLERERLEQEQLERER 195
+E E +R + +E++R+KE ERER ERER +R+R + +R+R ++E+
Sbjct: 320 RERREREREREREREREKEKERER-ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378
Query: 196 QERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
++R R R ER+ ER+ +RER+ +ERER ERER++ +++++ E E+
Sbjct: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438
Query: 256 LEWERER 262
+ER +
Sbjct: 439 DAYERRK 445
Score = 67.0 bits (162), Expect = 5e-11
Identities = 37/110 (33%), Positives = 73/110 (66%), Gaps = 4/110 (3%)
Query: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ-ERERQERLE 205
++ ++ +++L + + R ++LE E+ ++E+ ER+ +E+E+ ERER+ ERER ER E
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERERERERER-ERRE 324
Query: 206 RQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQ 255
R+ ER+ E+++ +RER+ ++R+R + +R+R +RER +RE+
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDR-DRERDRDRDRER 373
Score = 67.0 bits (162), Expect = 5e-11
Identities = 62/244 (25%), Positives = 107/244 (43%), Gaps = 43/244 (17%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERER- 195
+ E E +R + +E++R++E ERER + ++ +RE E + ER +LER+ E+E +ER
Sbjct: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461
Query: 196 ---QERERQERLERQERLERQERLERQERLDRERQERQE--------------------R 232
+ RER++ E ++ ER+E ER+ + +E + +E +
Sbjct: 462 KNWEIRERKKTREYEKEAEREE--ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQ 519
Query: 233 ERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVE------------TPLNSV 280
+RL E+E + ER + E+E+LE R+R ++ E P
Sbjct: 520 KRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQ 579
Query: 281 LGDSSASEPGLQAASQPAETP--SQQGIVLGPLAPPPPPPLPPGPAQASV---ALPPPPG 335
+S E Q + E P ++ P P P+ P+ +S A P PG
Sbjct: 580 EPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPG 639
Query: 336 PPPP 339
P
Sbjct: 640 DESP 643
Score = 66.6 bits (161), Expect = 6e-11
Identities = 43/150 (28%), Positives = 78/150 (52%), Gaps = 18/150 (12%)
Query: 137 QEELEIQRRQLQEQQRQKELERER-LERERMERERLERERLERERLERERLEQEQLERER 195
+ E + R + +E+ R ++ ER+R +RER +R R + +RER + + ERER
Sbjct: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
Query: 196 Q---ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ--------- 243
+ ERER+ ER+ ER+ +++ + + ++ ER +LER RE++
Sbjct: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
Query: 244 ----ERERQEQLERE-QLEWERERRISSAA 268
ER++ + E+E + E ER R ++ A
Sbjct: 464 WEIRERKKTREYEKEAEREEERRREMAKEA 493
Score = 66.6 bits (161), Expect = 6e-11
Identities = 41/126 (32%), Positives = 68/126 (53%), Gaps = 1/126 (0%)
Query: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQL 191
+N E R + +E++R++E ERER ERER ERER + ++ ++E+
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
Query: 192 ERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQL 251
E + ER + ER R++ QERL+ E +R++ E+E ER E R+E ++ +
Sbjct: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE-AEREEERRREMAKEAKR 495
Query: 252 EREQLE 257
+E LE
Sbjct: 496 LKEFLE 501
Score = 64.7 bits (156), Expect = 2e-10
Identities = 44/118 (37%), Positives = 75/118 (63%), Gaps = 16/118 (13%)
Query: 156 LERERLERERMERE----RLERERLERERLERERLEQEQLERERQERERQERLERQERLE 211
+E E +R+ + RE R ++LE E+ ++E+ E++++E+ER+ERER+ ER E
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-ERQEIEKERRERERERERER----E 321
Query: 212 RQERLERQERLDRERQERQERERLERLERER---QERERQEQLEREQLEWERERRISS 266
R+ER ER+ +RER++ +ERER +R+R +ER+R ER++ +R+R SS
Sbjct: 322 RRER-EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR---DRDRERSS 375
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/147 (32%), Positives = 80/147 (54%), Gaps = 25/147 (17%)
Query: 133 NGPSQEELEIQRRQLQEQQRQ-----------------KELERERLERERMERERLERER 175
N PSQE R++ +E++ KE + +E E +R+ + RE
Sbjct: 223 NAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKE-DINAIEMEEDKRDLISRE- 280
Query: 176 LERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERL 235
+ + R ++LE+E + ++E+ERQE +E++ R +ER +ER +RER+ +ERER
Sbjct: 281 ISKFRDTHKKLEEE---KGKKEKERQE-IEKERRERERERERERERRERERERERERERE 336
Query: 236 ERLERERQERERQEQLEREQLEWERER 262
+ ERER ERER +R + E +R+R
Sbjct: 337 KEKERER-ERERDRDRDRTK-ERDRDR 361
Score = 37.4 bits (85), Expect = 0.039
Identities = 19/44 (43%), Positives = 22/44 (50%), Gaps = 2/44 (4%)
Query: 332 PPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
PP PP +P+ PP PPP P PP PP P P+P S
Sbjct: 4 PPHLNRPPMGIPAL--PPGIPPPQFPGFPPPVPPGTPMIPVPMS 45
Score = 36.6 bits (83), Expect = 0.067
Identities = 20/67 (29%), Positives = 28/67 (41%), Gaps = 2/67 (2%)
Query: 320 PPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPP--PLPNQVPPPPPPPPAPPLPASGF 377
PP + + +P P PPP P PP PP P P+P + P P P + G
Sbjct: 4 PPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGK 63
Query: 378 FLASMSE 384
L + +
Sbjct: 64 HLGARKD 70
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 87.4 bits (215), Expect = 3e-17
Identities = 56/131 (42%), Positives = 61/131 (46%), Gaps = 30/131 (22%)
Query: 270 PASVETPLNSVLGDSSASEPGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLPPGPA 324
P + PL + G P L A+ P P GI L P P PPPPPLP
Sbjct: 927 PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLP---- 982
Query: 325 QASVALPPPP-----GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP----- 366
+PPPP G PPPPPLP G PPP PPPPPLP PPPPP
Sbjct: 983 --GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
Query: 367 -PPAPPLPASG 376
PP PPLP +G
Sbjct: 1041 IPPPPPLPGAG 1051
Score = 85.5 bits (210), Expect = 1e-16
Identities = 59/164 (35%), Positives = 72/164 (43%), Gaps = 45/164 (27%)
Query: 255 QLEWERERRISSAAAPA-SVETPLNSVLGDSSASEPGLQAASQPA--------------- 298
+ + E +SSA + ++ +P +SS+S PGL P
Sbjct: 836 EFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTA 895
Query: 299 --ETPSQQGIVLGPLAPPPPPPLP--------PGPAQASVALPPPPGP--PPPPPLPSTG 346
+ P QG + PPPPPPLP P P + LPP PG PPPPPLP
Sbjct: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
Query: 347 PPPPPP--------PPPLPNQVPPPPPP------PPAPPLPASG 376
PPPPP PPPLP PPPPP PP PPLP +G
Sbjct: 953 IPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
Score = 85.5 bits (210), Expect = 1e-16
Identities = 53/117 (45%), Positives = 55/117 (47%), Gaps = 29/117 (24%)
Query: 289 PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
P L A P P GI P P PPPPPLP P P +PPPP
Sbjct: 979 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1038
Query: 335 -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
G PPPPPLP G PPP PPPPPLP PPPPP PP PPLP +G
Sbjct: 1039 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
Score = 85.5 bits (210), Expect = 1e-16
Identities = 53/117 (45%), Positives = 55/117 (47%), Gaps = 29/117 (24%)
Query: 289 PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
P L A P P GI P P PPPPPLP P P +PPPP
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1082
Query: 335 -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
G PPPPPLP G PPP PPPPPLP PPPPP PP PPLP +G
Sbjct: 1083 AGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139
Score = 85.1 bits (209), Expect = 2e-16
Identities = 49/103 (47%), Positives = 51/103 (49%), Gaps = 24/103 (23%)
Query: 314 PPPPPLP-----PGPAQASVALPPPP-----GPPPPPPLPSTGPPPPPP--------PPP 355
PPPPPLP P P V +PPPP G PPPPPLP G PPPPP PPP
Sbjct: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1189
Query: 356 LPNQVPPPPPP------PPAPPLPASGFFLASMSEDNRPLTGL 392
LP PPPPP PP PPLP G A P TG+
Sbjct: 1190 LPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGI 1232
Score = 84.3 bits (207), Expect = 3e-16
Identities = 53/117 (45%), Positives = 54/117 (46%), Gaps = 29/117 (24%)
Query: 289 PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
P L A P P GI P P PPPPPLP P P +PPPP
Sbjct: 1067 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPG 1126
Query: 335 -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPP------PPAPPLPASG 376
G PPPPPLP G PPP PPPPPLP PPPPP PP PPLP G
Sbjct: 1127 AGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1183
Score = 84.0 bits (206), Expect = 4e-16
Identities = 53/117 (45%), Positives = 54/117 (46%), Gaps = 29/117 (24%)
Query: 289 PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
P L A P P GI P P PPPPPLP P P +PPPP
Sbjct: 1078 PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1137
Query: 335 -GPPPPPPLPSTGPPPPPP--------PPPLPNQVPPPPPP------PPAPPLPASG 376
G PPPPPLP G PPPPP PPPLP PPPPP PP PPLP G
Sbjct: 1138 AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVG 1194
Score = 80.1 bits (196), Expect = 5e-15
Identities = 50/111 (45%), Positives = 52/111 (46%), Gaps = 24/111 (21%)
Query: 289 PGLQAASQPAETPSQ-QGIVLGPLAP----PPPPPLP-----PGPAQASVALPPPP---- 334
P L A P P GI P P PPPPPLP P P +PPPP
Sbjct: 1122 PPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
Query: 335 -GPPPPPPLPSTGPPPP--------PPPPPLPNQVPPPPPPPPAPPLPASG 376
G PPPPPLP G PPP PPPPPLP PP P PP PP P +G
Sbjct: 1182 VGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP-PGTG 1231
Score = 75.1 bits (183), Expect = 2e-13
Identities = 40/75 (53%), Positives = 42/75 (56%), Gaps = 18/75 (24%)
Query: 314 PPPPPLPPGPAQASVALPPPP-----GPPPPPPLPSTGPPPPPPPPPL---PNQVPPPPP 365
PPPPPLP V +PPPP G PPPPPLP G PPPPP P + P PP PP
Sbjct: 1174 PPPPPLP------GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227
Query: 366 P----PPAPPLPASG 376
P PP P LP SG
Sbjct: 1228 PGTGIPPPPLLPVSG 1242
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/118 (39%), Positives = 53/118 (44%), Gaps = 25/118 (21%)
Query: 289 PGLQAASQPAETPSQQGIVLGPLAP------PPPPPLP-----PGPAQASVALPPPPGPP 337
P L A P P G+ + P P PPPPPLP P P + +PP P PP
Sbjct: 1166 PPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPP 1224
Query: 338 PPPPLPSTGPPPPP----PPPPLPNQVPPPPPPPP------APPLPASGFFLASMSED 385
PP P TG PPPP PPL QV P P PPLP SG F M++D
Sbjct: 1225 LPP--PGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP-SGLFGLGMNQD 1279
Score = 38.5 bits (88), Expect = 0.018
Identities = 69/296 (23%), Positives = 99/296 (33%), Gaps = 111/296 (37%)
Query: 182 ERERLEQEQLERERQERER-QERLERQERLERQERLERQERLDRERQERQE--RERLERL 238
E RLE + E + E Q+R + ++ + E Q + ++ ++ E R ++ L
Sbjct: 634 EEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAEL 693
Query: 239 ERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSV-LGDSSASEPGLQAASQP 297
ER+ + + + LE AS + L ++ L + + A
Sbjct: 694 ERQYPALDTEVASGHQGLE---------NGVTASGDVCLEALRLEEKEVRHHRILEAKSI 744
Query: 298 AETPSQQGIVLGPLAP----PPPPPLPPG------------------PAQASVALPPPP- 334
+P+++G VL L P P PP PPG P + SV L
Sbjct: 745 QTSPTEEGGVL-TLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQP 803
Query: 335 ----GPPPPPP--LPSTG------------------------------------PPP--- 349
PPPPP L S G PPP
Sbjct: 804 TQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863
Query: 350 -------------PPPPPPLPNQ---------VPPPPP-------PPPAPPLPASG 376
PPPPPPLP +P PPP PPP PPLP +G
Sbjct: 864 TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAG 919
Score = 36.6 bits (83), Expect = 0.067
Identities = 36/148 (24%), Positives = 57/148 (38%), Gaps = 19/148 (12%)
Query: 230 QERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLG-DSSASE 288
Q+ RL++ ++++ + + Q+Q +++QL+ E AA P +V + LG D
Sbjct: 200 QQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEE----PAAPPTAVSPQPGAFLGLDRFLLG 255
Query: 289 PGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPP 348
P A P ++Q L L+ P +L P P PP P P
Sbjct: 256 PSGGAGEAPGSPDTEQA--LSALSDLPE------------SLAAEPREPQQPPSPGGLPV 301
Query: 349 PPPPPPPLPNQVPPPPPPPPAPPLPASG 376
P P P A P P +G
Sbjct: 302 SEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 86.7 bits (213), Expect = 6e-17
Identities = 89/331 (26%), Positives = 123/331 (37%), Gaps = 48/331 (14%)
Query: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS----SAAAPA 271
LER R+ R R + LE+ Q+R + + + R+ A PA
Sbjct: 51 LERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPA 110
Query: 272 SVETPLNSVLGDSSASEPGLQA---------ASQPAETPSQQGIVLGPLAPPPPPPLPPG 322
P + ++A+ P A A+ PA P + APP P P PG
Sbjct: 111 PPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAP--RAAAAAATAPPSPGPAQPG 168
Query: 323 PAQ---ASVALPPP-PGPPP---PPPLPSTGPPP----------PPPPPPLPNQVPPPPP 365
P A +A PPP P PP PP P PPP PPP PP P Q PPP
Sbjct: 169 PRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPP 228
Query: 366 PPPAPPLPASGFFLA-------SMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNA 418
P P PP P G A S+ E R L G A +V + + + G
Sbjct: 229 PQPQPP-PEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRL 287
Query: 419 IGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSE 478
+ G G P SA +R +R E+ +E E++ED ED +
Sbjct: 288 ERTRLGALALPRGDRPGRAP-------PAASARPSRSKRGGEE-RVLEKEEEEDDDEDED 339
Query: 479 PVTSKASSTSTPEPTRKPWERTNTMNGSKSP 509
+ + PE R + + +NG + P
Sbjct: 340 EEDDVSEGSEVPESDRPAGAQHHQLNGERGP 370
Score = 43.5 bits (101), Expect = 5e-04
Identities = 60/190 (31%), Positives = 77/190 (40%), Gaps = 17/190 (8%)
Query: 160 RLERERMERERLERERLERERLERERLEQEQLER-ERQERERQERLERQERLER--QER- 215
RL R R++ LE E R RLER RL L R +R R R R +R +ER
Sbjct: 267 RLTRGRVQG-LLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERV 325
Query: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVET 275
LE++E D + E +E + E E E +R + QL ER + SA T
Sbjct: 326 LEKEEEEDDDEDEDEEDDVSEG--SEVPESDRPAGAQHHQLNGERGPQ--SAKERVKEWT 381
Query: 276 PLNSVLGDSSASEP----GLQAASQPAETPSQQG---IVLGPLAPPPPPPLPPGPAQASV 328
P G P G + A + G + GP + P P PLPPG
Sbjct: 382 PCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDS-PSPVPLPPGKPALPG 440
Query: 329 ALPPPPGPPP 338
A P G PP
Sbjct: 441 ADGTPFGCPP 450
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 86.3 bits (212), Expect = 7e-17
Identities = 118/465 (25%), Positives = 186/465 (40%), Gaps = 60/465 (12%)
Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEEL--EIQRRQLQEQQRQKELERERLERERM 166
E S+E +P Q + P+ + N P + L + R Q + ++R + L R++L +E+
Sbjct: 322 EYSGSEEEEEEVPEQEGE-PSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQ 380
Query: 167 ERERLE---------RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLE 217
RE+ E ++R+E+++ +R RLE++Q R+ERE + + ER++R QE
Sbjct: 381 LREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ----RREREARRQQEREQRRREQEEKR 436
Query: 218 RQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPL 277
R E L+R R+E +ER R E E++ ER+++ R QLE E +R + E +
Sbjct: 437 RLEELERRRKEEEER---RRAEEEKRRVEREQEYIRRQLE-EEQRHLEVLQQQLLQEQAM 492
Query: 278 NSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337
+L D P Q + QP P Q+ AP P P V + P
Sbjct: 493 --LLHDHRRPHP--QHSQQP-PPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSP 547
Query: 338 ----PPPPLPSTGPPPPPPPPPLPNQVPPP----PPPPPAPPLPASGFFLASMSEDNRPL 389
PL +G P P P SG S + ++P
Sbjct: 548 VLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPG 607
Query: 390 TGLAA-AIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGG----SGL 444
+ + + +G + R S + PS V K + R PL G + L
Sbjct: 608 SHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFR---PLKPAGEVDLTAL 664
Query: 445 MEEMSALLARR--RRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNT 502
+E+ A+ R ++ + S+ E D+ +D STS PE TR N
Sbjct: 665 AKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA-SSLNL 723
Query: 503 MNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANG 547
NG V K IV D+ +S P PS G
Sbjct: 724 SNGETESV--------KTMIVHDD--------VESEPAMTPSKEG 752
Score = 76.6 bits (187), Expect = 6e-14
Identities = 119/502 (23%), Positives = 199/502 (39%), Gaps = 67/502 (13%)
Query: 131 VQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERE---------------- 174
+++ P++ ++ IQ + ++ R+K E++ E E E E E
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 175 ---------RLERERLER-ERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
RL++E ER E L ++QL +E+Q RE QE +RQ ERQ+R+E+Q+ R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLRE-QEEYKRQLLAERQKRIEQQKEQRR 407
Query: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS-----VETPLNS 279
+E+Q RER R ++ER++R R+++ +R E ER R+ A VE
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467
Query: 280 VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPP 339
+ + L+ Q + +Q ++L P P Q S PPP
Sbjct: 468 IRRQLEEEQRHLEVLQQ--QLLQEQAMLLHDHRRPHP--------QHSQQPPPPQQERSK 517
Query: 340 PPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGA 399
P + P P +V P +P L L + N G + +
Sbjct: 518 PSFHAPEPKAHYEPADRAREV-PVRTTSRSPVLSRRDSPLQGSGQQNSQ-AGQRNSTSSI 575
Query: 400 KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIA 459
+ R + + P G+ G +S SS + + G+ P GSG E + + +
Sbjct: 576 EPRLLWERVEKLVPRPGS--GSSSGSSNSGSQPGSHPGSQSGSG---ERFRVRSSSKSEG 630
Query: 460 EKGSTIETEQK--EDKGEDSEP--------VTSKASSTSTPEPTRKPWERTNTMNGSKSP 509
+E K EDK E P +T+ A E R P + T+ + S+
Sbjct: 631 SPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEES 690
Query: 510 VISRRDSPRKNQIVFDNRSYDSLHRPKST-PLSQPSANGVQTEGLDYDRLKQDILDEMRK 568
+ + Q D +S P+ T S + + +TE + + D+ E
Sbjct: 691 GTTDEEDDDVEQEGAD----ESTSGPEDTRAASSLNLSNGETESVKTMIVHDDV--ESEP 744
Query: 569 ELTKLKEELIDAIRQELSKSNT 590
+T KE + +RQ S S+T
Sbjct: 745 AMTPSKEGTL-IVRQTQSASST 765
Score = 33.9 bits (76), Expect = 0.43
Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
L + ++R E+ + R + ERQ R++ ++ +DR R++R E++ E E E
Sbjct: 270 LVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETE-YEYSGSEE 328
Query: 246 ERQEQLERE 254
E +E E+E
Sbjct: 329 EEEEVPEQE 337
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 86.3 bits (212), Expect = 7e-17
Identities = 112/442 (25%), Positives = 181/442 (40%), Gaps = 79/442 (17%)
Query: 109 EVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMER 168
E S+E +P Q + P+ + N P + L +LQ++ +++ E L R+++ +
Sbjct: 322 EYSGSEEEEEEVPEQEGE-PSSIVNVPGESTLRRDFLRLQQENKERS---EALRRQQLLQ 377
Query: 169 ERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQE 228
E+ RE+ E +R +L E+ +R Q++E++ RLE Q+R ER+ R RQ+ ++ R+E
Sbjct: 378 EQQLREQEEYKR----QLLAERQKRIEQQKEQRRRLEEQQRREREAR--RQQEREQRRRE 431
Query: 229 RQERERLERLERERQERERQEQLEREQLEWERER---RISSAAAPASVETPLNSVLGDSS 285
++E+ RLE LER R+E E + + E E+ ERE+ R +E +L + +
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Query: 286 --------ASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337
E QA + +Q +L L P P Q
Sbjct: 492 MLLECRWREMEEHRQAERLQRQLQQEQAYLLS-LQHDHRRPHPQHSQQ------------ 538
Query: 338 PPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIA 397
PPPP P P P + P A ED T ++ A
Sbjct: 539 PPPPQQERSKPSFHAPEPKAHYEPAD---------------RAREVEDRFRKTNHSSPEA 583
Query: 398 GAKLRKVSRMEDTSFP------SGGNAIGVNSASSKTD---------TGRGNGPLPLGGS 442
+K + R+ + P S GN+ V+ A + N P+ S
Sbjct: 584 QSK--QTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRS 641
Query: 443 GLMEEMSALLARRRRIAE-----KGSTIETEQKEDKGEDSEPVTSKASSTSTPE--PTRK 495
+ S A ++ S + ++ + K E +P T KA S S + P R
Sbjct: 642 HSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDP-TQKAWSRSDSDEVPPRV 700
Query: 496 PWERTNTMNGSKSPVISRRDSP 517
P T S+SPV+SRRDSP
Sbjct: 701 PVRTT-----SRSPVLSRRDSP 717
Score = 72.8 bits (177), Expect = 8e-13
Identities = 50/159 (31%), Positives = 85/159 (53%), Gaps = 27/159 (16%)
Query: 131 VQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERE---------------- 174
+++ P++ ++ IQ + ++ R+K E++ E E E E E
Sbjct: 289 IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG 348
Query: 175 ---------RLERERLER-ERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
RL++E ER E L ++QL +E+Q RE QE +RQ ERQ+R+E+Q+ R
Sbjct: 349 ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLRE-QEEYKRQLLAERQKRIEQQKEQRR 407
Query: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERR 263
+E+Q RER R ++ER++R R+++ +R E ER R+
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446
Score = 60.1 bits (144), Expect = 6e-09
Identities = 117/519 (22%), Positives = 199/519 (38%), Gaps = 78/519 (15%)
Query: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERER------LERER----- 185
Q+E E +RR+ +E++R +ELER R E E R E+ R+ERE+ LE E+
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEV 481
Query: 186 LEQEQLE----------RERQERERQERLERQERLERQERLERQERLDRERQERQERERL 235
L+Q+ L+ RE +E + ERL+RQ + E+ L Q R + ++
Sbjct: 482 LQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPP 541
Query: 236 ERLERER------QERERQEQLEREQLEWERERRISSAAAPAS-------VETPLNS--- 279
+ ER + + + E +R + +R R+ + ++ A +E P+ S
Sbjct: 542 PQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSE 601
Query: 280 --VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAP--------PPPPPLPPGPAQASVA 329
G+S + P LQ ++P S + ++P P P ++
Sbjct: 602 SFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDP 661
Query: 330 LPPPPGPPPPPPLPSTGPPPPPPPPPL----PNQVPPPPP---PPPAPPLPASGFFLASM 382
PP S P P ++VPP P +P L L
Sbjct: 662 CPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGS 721
Query: 383 SEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGS 442
+ N G + + + R + + P G+ G +S SS + + G+ P GS
Sbjct: 722 GQQNSQ-AGQRNSTSSIEPRLLWERVEKLVPRPGS--GSSSGSSNSGSQPGSHPGSQSGS 778
Query: 443 GLMEEMSALLARRRRIAEKGSTIETEQK--EDKGEDSEP--------VTSKASSTSTPEP 492
G E + + + +E K EDK E P +T+ A E
Sbjct: 779 G---ERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVED 835
Query: 493 TRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKST-PLSQPSANGVQTE 551
R P + T+ + S+ + + Q D +S P+ T S + + +TE
Sbjct: 836 VRPPHKVTDYSSSSEESGTTDEEDDDVEQEGAD----ESTSGPEDTRAASSLNLSNGETE 891
Query: 552 GLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNT 590
+ + D+ E +T KE + +RQ S S+T
Sbjct: 892 SVKTMIVHDDV--ESEPAMTPSKEGTL-IVRQTQSASST 927
Score = 33.9 bits (76), Expect = 0.43
Identities = 20/69 (28%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 186 LEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQER 245
L + ++R E+ + R + ERQ R++ ++ +DR R++R E++ E E E
Sbjct: 270 LVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETE-YEYSGSEE 328
Query: 246 ERQEQLERE 254
E +E E+E
Sbjct: 329 EEEEVPEQE 337
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 86.3 bits (212), Expect = 7e-17
Identities = 48/136 (35%), Positives = 62/136 (45%), Gaps = 9/136 (6%)
Query: 243 QERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPS 302
++ + +Q E +E + S+ A P+ G ++ + P + A + P P
Sbjct: 626 EKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPP- 684
Query: 303 QQGIVLGPLAPPPPPPLPPGPAQASVALPPP-PGPPPPPPLPSTGPPPPPPPPPLPNQVP 361
P PP PPP PP P Q +PPP P PPPPPP PPPP P P VP
Sbjct: 685 -------PGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVP 737
Query: 362 PPPPPPPAPPLPASGF 377
PPP PP PP P F
Sbjct: 738 PPPILPPLPPFPPGLF 753
Score = 72.8 bits (177), Expect = 8e-13
Identities = 88/365 (24%), Positives = 143/365 (39%), Gaps = 62/365 (16%)
Query: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERL 181
R+ P ++ +G ++E E + + + ++E E E E + + + +R+ E +
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESEND-- 1077
Query: 182 ERERLEQEQLERERQERERQERLE----RQERLERQERLERQE-RLDRERQERQERERLE 236
+ + E E++ + + +E + + E E E E E + E
Sbjct: 1078 DEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEE 1137
Query: 237 RLERERQERERQEQLEREQ---------LEWERERRISSAAAPA--------SVETPLNS 279
+ RE +E E +E++ E+ E + E + APA V+ +
Sbjct: 1138 VVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEA 1197
Query: 280 VLGDSSAS---EPGLQA-------ASQPAETP--SQQGIVLGPLAPPPP-------PPLP 320
V + S EP L + +P E P SQ+G +L L+P PP PPL
Sbjct: 1198 VAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAML--LSPEPPAKEVEARPPLS 1255
Query: 321 PGPA---QASVALPPPPGPPPP--PPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
P A V PP P P PPLP PP PP PPP P P P PL
Sbjct: 1256 PERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPL--- 1312
Query: 376 GFFLASMSEDNRPLT-GLAAAIAGAK-LRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRG 433
+ED+ P T GL ++A ++ V P G + G++ +S +
Sbjct: 1313 -------AEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPF 1365
Query: 434 NGPLP 438
+ P P
Sbjct: 1366 SYPAP 1370
Score = 60.5 bits (145), Expect = 4e-09
Identities = 43/116 (37%), Positives = 48/116 (41%), Gaps = 19/116 (16%)
Query: 269 APASVETPLNSVLGDSSAS--EPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQA 326
A A TPL +L AS P + +P +P + GPL PP A
Sbjct: 1449 AQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPP------AGAAL 1502
Query: 327 SVALPPPPGPPPPPPLPSTGPPP-----------PPPPPPLPNQVPPPPPPPPAPP 371
L PG P P PST P P PPPPLP Q PPPPPPPP P
Sbjct: 1503 GRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEP 1558
Score = 47.0 bits (110), Expect = 5e-05
Identities = 41/143 (28%), Positives = 51/143 (35%), Gaps = 29/143 (20%)
Query: 265 SSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPA 324
++AA S + P +V G +S P +A Q + T + PPP P P
Sbjct: 342 ATAAFRGSSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHT---------PPPAQATPAPG 392
Query: 325 QASVALP---PPPGPPPPPPLPSTGP-------------PPPPPPPPLPNQVPPPPPPPP 368
S P P PPPP P+ P PPP PP P PP
Sbjct: 393 FKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPP 452
Query: 369 APPLPASGFFLASMSEDNRPLTG 391
PP P + SM RP G
Sbjct: 453 GPPPPDTN----SMELGGRPTFG 471
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/95 (32%), Positives = 33/95 (34%), Gaps = 41/95 (43%)
Query: 313 PPPPPPLPPGPAQASVALPPPPGPPP--PPPLP--------------------------- 343
P PPPPLPP P PPPP PPP P LP
Sbjct: 1537 PAPPPPLPPQP-------PPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEY 1589
Query: 344 -----STGPPPPPPPPPLPNQVPPPPPPPPAPPLP 373
S GP PP + VPP P +PP P
Sbjct: 1590 MELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQP 1624
Score = 40.0 bits (92), Expect = 0.006
Identities = 52/214 (24%), Positives = 69/214 (32%), Gaps = 82/214 (38%)
Query: 234 RLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQA 293
R+E L +E +R + L + E + S ++ +S +PL + S+PG +
Sbjct: 502 RIEMLLKE--QRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPF---GTNSQPGFRG 556
Query: 294 ASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVAL------PPPPGPPPP-------- 339
+ P+ PS G L P PLP + L PP PGPP P
Sbjct: 557 PTPPSSRPSSTG-----LEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTA 611
Query: 340 -----------------------------------PPLPSTGPPPPPP------------ 352
P P T P P
Sbjct: 612 EVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAA 671
Query: 353 ----PPPLPNQVPPPP-----PPPPAPPLPASGF 377
P LP +PPPP PPPP PP P GF
Sbjct: 672 PSVLAPTLP--LPPPPGFPPLPPPPPPPPPQPGF 703
Score = 39.3 bits (90), Expect = 0.010
Identities = 23/64 (35%), Positives = 25/64 (39%), Gaps = 7/64 (10%)
Query: 314 PPPPPLPPGPAQASVALPPPPGPPPPPP-------LPSTGPPPPPPPPPLPNQVPPPPPP 366
P PPPLPP A PPGPPPP P+ G P P P + P
Sbjct: 432 PAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAG 491
Query: 367 PPAP 370
P P
Sbjct: 492 PEKP 495
Score = 35.4 bits (80), Expect = 0.15
Identities = 23/56 (41%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 310 PLAPPPPPPLP---PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPP 362
PL P P PLP P +A P P P P PL S PPP P P + PP
Sbjct: 1430 PLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASC-PPPMKRKPGRPRRSPP 1484
Score = 32.7 bits (73), Expect = 0.96
Identities = 32/103 (31%), Positives = 42/103 (40%), Gaps = 12/103 (11%)
Query: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQAS----- 327
++ ++ VLG P S +T ++ G A P PP + A AS
Sbjct: 756 MQVDMSHVLGGQWGGMP----MSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQF 811
Query: 328 VALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAP 370
V LPP GP L ++GP PPLP P PPP P
Sbjct: 812 VNLPPYRGPFS---LSNSGPGRGQHWPPLPKFDPSVPPPGYMP 851
Score = 32.7 bits (73), Expect = 0.96
Identities = 43/134 (32%), Positives = 50/134 (37%), Gaps = 26/134 (19%)
Query: 265 SSAAAPASV--ETPLNSVLGDSSASEPGLQAA--SQPAETPSQQGIVLGPLAP------P 314
S+ PA+ E PL+ S S P + + S PA +PS L P P
Sbjct: 1332 STETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGL-PRTPGRDFSFT 1390
Query: 315 PPPPLPPGPAQASVALPPP------PGPPPPPPLPSTGPPPPPPPP-PLPNQVPP----- 362
P P GP V P GP P L TG P P P P PLP +P
Sbjct: 1391 PTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQ 1450
Query: 363 ---PPPPPPAPPLP 373
P P PP P P
Sbjct: 1451 ARAPTPLPPLLPAP 1464
Score = 31.6 bits (70), Expect = 2.1
Identities = 31/115 (26%), Positives = 41/115 (35%), Gaps = 13/115 (11%)
Query: 269 APASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPP--------PPLP 320
+P S P S+ PG + P + G +L P+ P P P
Sbjct: 1363 SPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFS-EPSGPLLLPVCPLPTGRRDERSGPLAS 1421
Query: 321 PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPP----PPPPPAPP 371
P + + LP P P P LP+ P PLP +P P PPP P
Sbjct: 1422 PVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKP 1476
Score = 30.4 bits (67), Expect = 4.8
Identities = 28/87 (32%), Positives = 34/87 (39%), Gaps = 14/87 (16%)
Query: 261 ERRISSAAAPASVETPLNSVLGDSSASEPGL---QAASQPAETPSQQGIVLGPLAPPPPP 317
E + A+ P+ PL D PGL A SQ ET P P P
Sbjct: 1296 EPETTDASHPSVPPEPLAE---DHPPHTPGLCGSLAKSQSTETV--------PATPGGEP 1344
Query: 318 PLPPGPAQASVALPPPPGPPPPPPLPS 344
PL G + S++ P PG P P PS
Sbjct: 1345 PLSGGSSGLSLSSPQVPGSPFSYPAPS 1371
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,958,170
Number of Sequences: 37866
Number of extensions: 2705962
Number of successful extensions: 189434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2916
Number of HSP's successfully gapped in prelim test: 2106
Number of HSP's that attempted gapping in prelim test: 25163
Number of HSP's gapped (non-prelim): 50406
length of query: 591
length of database: 18,247,518
effective HSP length: 108
effective length of query: 483
effective length of database: 14,157,990
effective search space: 6838309170
effective search space used: 6838309170
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.