Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 55956923
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 854 0.0
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 297 1e-80
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 288 8e-78
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 265 8e-71
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 248 6e-66
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 243 2e-64
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 228 1e-59
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 224 1e-58
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 224 1e-58
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 224 1e-58
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 219 5e-57
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 214 2e-55
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 211 1e-54
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 210 2e-54
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 209 3e-54
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 209 3e-54
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 203 2e-52
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 199 4e-51
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 197 2e-50
gi|32483397 dopamine receptor D4 [Homo sapiens] 194 1e-49
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 178 9e-45
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 173 2e-43
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 173 2e-43
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 854 bits (2206), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA 60
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
Sbjct: 1 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA 60
Query: 61 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 120
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
Sbjct: 61 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 120
Query: 121 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED 180
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
Sbjct: 121 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED 180
Query: 181 RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT 240
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
Sbjct: 181 RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT 240
Query: 241 RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN 300
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
Sbjct: 241 RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN 300
Query: 301 SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP 360
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
Sbjct: 301 SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP 360
Query: 361 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC 420
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
Sbjct: 361 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC 420
Query: 421 RQ 422
RQ
Sbjct: 421 RQ 422
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 297 bits (760), Expect = 1e-80
Identities = 160/392 (40%), Positives = 228/392 (58%), Gaps = 52/392 (13%)
Query: 31 VTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVL 90
+++ ++V+ +LL + L NA V+A + R L ANYLI SLAVTDL+VS+LV+
Sbjct: 44 ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVM 103
Query: 91 PMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTP 150
P++ +Y V +WTLGQV CD +++ D+ CCT+SILHLC IALDRYWAITD ++Y KRTP
Sbjct: 104 PISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTP 163
Query: 151 RRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLL 209
+RAA +I+L W+ IS+PP WR + + C ++ DH YT+YST GAFY P L
Sbjct: 164 KRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTL 222
Query: 210 LMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVES 269
L++ LYGRI+ AR RI K +G R R + +
Sbjct: 223 LLIALYGRIYVEARSRI------------------------LKQTPNRTGKRLTRAQLIT 258
Query: 270 KAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNA 329
+ G+ + ++ RV + +PSE+G +P + R +
Sbjct: 259 DSPGSTSSVTSINS-------------RVPD------VPSESG----SPVYVNQVKVRVS 295
Query: 330 EA---KRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIIN 386
+A K+K+ ARERK KTLGII+G FI+CWLPFFI++LV+P C+ +C +
Sbjct: 296 DALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFT 355
Query: 387 WLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
WLGY NSL+NP+IY N+DF+ AF K+I+ K
Sbjct: 356 WLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK 387
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 288 bits (736), Expect = 8e-78
Identities = 156/382 (40%), Positives = 220/382 (57%), Gaps = 50/382 (13%)
Query: 36 QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL 95
++ +++L + VL NA V+ I L R L ANYLIGSLA TDL+VS+LV+P++
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
Query: 96 YQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAA 155
Y + + W GQ+ CD++++ D+ CCT+SILHLC IALDRYWAITD ++Y +RT AA
Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Query: 156 LISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLLLMLVL 214
+I++ W I ISIPP+ WR + + + C ++ YTIYST GAFYIP +L+++L
Sbjct: 158 MIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIIL 216
Query: 215 YGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGA 274
YGRI+RAAR RI P+ K+ + AG +
Sbjct: 217 YGRIYRAARNRILN----------------PPSLYGKRFTTAHL--------ITGSAGSS 252
Query: 275 LCA-NGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKR 333
LC+ N ++ +G H G+ PL A ++ ERK
Sbjct: 253 LCSLNSSLHEGHS---------HSAGS-----PLFFNHVKIKLADSALERK--------- 289
Query: 334 KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNS 393
+++ ARERK K LGII+G FI+CWLPFF+V+LVLP C SC + L WLGY NS
Sbjct: 290 RISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNS 349
Query: 394 LLNPVIYAYFNKDFQNAFKKII 415
L+NP+IY FN++F+ AF+KI+
Sbjct: 350 LINPIIYTVFNEEFRQAFQKIV 371
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 265 bits (676), Expect = 8e-71
Identities = 150/388 (38%), Positives = 224/388 (57%), Gaps = 50/388 (12%)
Query: 36 QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAAL 95
+++ SL L L N+ V+AAI + R L + ANYLI SLAVTD +V+VLV+P + +
Sbjct: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIV 82
Query: 96 YQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAA 155
Y V W +GQV CD+++++D+ CCT SILHL AIALDRY AITD ++Y KRTP+ A
Sbjct: 83 YIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
Query: 156 LISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH-GYTIYSTFGAFYIPLLLMLVL 214
+I++ W+I IS+PP+ WR + S D C I DH TIYSTFGAFYIPL L+L+L
Sbjct: 143 MITIVWIISVFISMPPLF-WR-HQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILIL 200
Query: 215 YGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNG----ESGSRNWRLGVESK 270
Y +I+RAA+ H + K+ VNG ESG ++ +
Sbjct: 201 YYKIYRAAK---------------TLYHKRQASRIAKEEVNGQVLLESGEKSTK------ 239
Query: 271 AGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAE 330
++ + + + + + ++H S E K+E++
Sbjct: 240 ---SVSTSYVLEKSLSDPSTDFDKIHSTVRSLRS-----------------EFKHEKSWR 279
Query: 331 AKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGY 390
++K++ RERK TLG+I+G F++CWLPFF+ LV+ C+ C + + + WLGY
Sbjct: 280 -RQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCD-KCKISEEMSNFLAWLGY 337
Query: 391 SNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
NSL+NP+IY FN+DF+ AF+K+++C+
Sbjct: 338 LNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 248 bits (634), Expect = 6e-66
Identities = 147/389 (37%), Positives = 217/389 (55%), Gaps = 46/389 (11%)
Query: 32 TVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP 91
T++ +++ + L + L N V+ AI + L ANYLI SLAVTDL+V+VLV+P
Sbjct: 18 TITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP 77
Query: 92 MAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPR 151
++ +Y V+++W LG C++++++D+ CCT SILHLC IALDRYWAIT+ I+Y KRT +
Sbjct: 78 LSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAK 137
Query: 152 RAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDA-CTISKDHG-YTIYSTFGAFYIPLL 209
RAA +I W I IS+PP+ WR+ S P + CTI DH YTIYST GAFYIPL
Sbjct: 138 RAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
Query: 210 LMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVES 269
L+L+LY RI+ AA K + + +RH ++ + + S
Sbjct: 197 LILILYYRIYHAA--------KSLYQKRGSSRHLSNRSTDSQNSF------------ASC 236
Query: 270 KAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNA 329
K C + D + E + S P ++ + ER
Sbjct: 237 KLTQTFCVS------DFSTSDPTTEFEKFHASIRIPPFDND----------LDHPGER-- 278
Query: 330 EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLG 389
++++ RERK + LG+I+G FIL WLPFFI L++ S + + + + WLG
Sbjct: 279 ---QQISSTRERKAARILGLILGAFILSWLPFFIKELIVGL--SIYTVSSEVADFLTWLG 333
Query: 390 YSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
Y NSL+NP++Y FN+DF+ AFKK+I+C+
Sbjct: 334 YVNSLINPLLYTSFNEDFKLAFKKLIRCR 362
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 243 bits (621), Expect = 2e-64
Identities = 146/404 (36%), Positives = 211/404 (52%), Gaps = 38/404 (9%)
Query: 42 LLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK 101
++G LI V+GN VV A+ R+L+ N + SLA D++V+ LV+P + +++
Sbjct: 57 VVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAY 116
Query: 102 WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTW 161
W GQV C +++ALDVL CTSSI+HLCAI+LDRYW++T ++Y KRTPRR A I W
Sbjct: 117 WYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVW 176
Query: 162 LIGFLISIPPMLG-WRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFR 220
LI +IS PP++ +R P+ + P C ++ + Y + S G+F+ P L+M ++Y RI+R
Sbjct: 177 LISAVISFPPLVSLYRQPDGAAYPQ-CGLNDETWYILSSCIGSFFAPCLIMGLVYARIYR 235
Query: 221 AARFRIRKTVKKVEKTGADTRHGASP------------------APQPKKSVNGESGSRN 262
A+ R R +K G D GASP AP P ES +
Sbjct: 236 VAKLRTRTLSEKRAPVGPD---GASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAA 292
Query: 263 WRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPAS-- 320
R + GAL G R G +G A + E L + P P S
Sbjct: 293 ER----RRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRA 348
Query: 321 ---------FERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFC 371
R+ R++ +RK+A ARE++ L ++MG F+LCW PFF + C
Sbjct: 349 SSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGIC 408
Query: 372 ESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
+C +P L W+GY NS LNPVIY FN+DF+ +FK I+
Sbjct: 409 REACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL 452
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 228 bits (580), Expect = 1e-59
Identities = 137/424 (32%), Positives = 220/424 (51%), Gaps = 74/424 (17%)
Query: 9 GNNTTSPP-----------APFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACV 57
G+NT++P P +T N+T + + ++ + L+LG I A++GN V
Sbjct: 8 GHNTSAPAHWGELKNANFTGPNQTSSNST-LPQLDITRAISVGLVLGAFILFAIVGNILV 66
Query: 58 VAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDV 117
+ ++A R L+ NY I +LA+ DL++S VLP +A +VL W LG++ CD++ A+DV
Sbjct: 67 ILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDV 126
Query: 118 LCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRT 177
LCCT+SIL LCAI++DRY + + Y T R+A + W++ +ISI P+LGW+
Sbjct: 127 LCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKE 186
Query: 178 PEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTG 237
P D + C ++++ Y ++S+ G+FYIPL ++LV+Y R++ A ++T K +E
Sbjct: 187 PAPNDDKE-CGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA----KRTTKNLEA-- 239
Query: 238 ADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHR 297
G +++ + L + +H
Sbjct: 240 -----------------------------------------GVMKEMSNSKEL-TLRIHS 257
Query: 298 VGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILC 357
++ L G P R++ A + +RE+K KTLGI++G FILC
Sbjct: 258 KNFHEDTLSSTKAKGHNP-----------RSSIAVKLFKFSREKKAAKTLGIVVGMFILC 306
Query: 358 WLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
WLPFFI AL L S+ P + ++ WLGY NS LNP+IY +K+F+ AF +I+ C
Sbjct: 307 WLPFFI-ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
Query: 418 KFCR 421
+ CR
Sbjct: 366 Q-CR 368
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 224 bits (570), Expect = 1e-58
Identities = 138/419 (32%), Positives = 218/419 (52%), Gaps = 74/419 (17%)
Query: 10 NNTTSPPAPFETG--GNTTGISDVTVSYQVITSLLLGTLI----FCAVLGNACVVAAIAL 63
+ T+ PAP N +G + ++Y + +++G+++ + GN VV ++
Sbjct: 50 SEVTASPAPTWDAPPDNASGCGE-QINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCF 108
Query: 64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTS 122
+ L+ +NYLI SLA+ DL V+V V+P ++ ++ KW G C++FIA+DV+CCT+
Sbjct: 109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTA 168
Query: 123 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRS 182
SI+ LC I++DRY IT P+ Y ++ + A +I WL+ I++PP+ GW ++ +
Sbjct: 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVN 226
Query: 183 DPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRH 242
D C IS+D GYTIYST AFYIP+ +ML +Y +I++AAR K+ A +
Sbjct: 227 DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR-----------KSAAKHKF 275
Query: 243 GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK 302
P +P + NG V+ EV E
Sbjct: 276 PGFPRVEP---------------------DSVIALNGIVK-----LQKEVEE-------- 301
Query: 303 EHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFF 362
CA S K+ER K RE+K TLGII+G F +CWLPFF
Sbjct: 302 -------------CANLSRLLKHER----KNISIFKREQKAATTLGIIVGAFTVCWLPFF 344
Query: 363 IVALVLPF-CESSCH-MPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
+++ PF C +SC +P + WLGY+NSL+NP IYA+FN+D + ++ +++C++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 224 bits (570), Expect = 1e-58
Identities = 138/419 (32%), Positives = 218/419 (52%), Gaps = 74/419 (17%)
Query: 10 NNTTSPPAPFETG--GNTTGISDVTVSYQVITSLLLGTLI----FCAVLGNACVVAAIAL 63
+ T+ PAP N +G + ++Y + +++G+++ + GN VV ++
Sbjct: 50 SEVTASPAPTWDAPPDNASGCGE-QINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCF 108
Query: 64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTS 122
+ L+ +NYLI SLA+ DL V+V V+P ++ ++ KW G C++FIA+DV+CCT+
Sbjct: 109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTA 168
Query: 123 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRS 182
SI+ LC I++DRY IT P+ Y ++ + A +I WL+ I++PP+ GW ++ +
Sbjct: 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVN 226
Query: 183 DPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRH 242
D C IS+D GYTIYST AFYIP+ +ML +Y +I++AAR K+ A +
Sbjct: 227 DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR-----------KSAAKHKF 275
Query: 243 GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK 302
P +P + NG V+ EV E
Sbjct: 276 PGFPRVEP---------------------DSVIALNGIVK-----LQKEVEE-------- 301
Query: 303 EHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFF 362
CA S K+ER K RE+K TLGII+G F +CWLPFF
Sbjct: 302 -------------CANLSRLLKHER----KNISIFKREQKAATTLGIIVGAFTVCWLPFF 344
Query: 363 IVALVLPF-CESSCH-MPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
+++ PF C +SC +P + WLGY+NSL+NP IYA+FN+D + ++ +++C++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 224 bits (570), Expect = 1e-58
Identities = 138/419 (32%), Positives = 218/419 (52%), Gaps = 74/419 (17%)
Query: 10 NNTTSPPAPFETG--GNTTGISDVTVSYQVITSLLLGTLI----FCAVLGNACVVAAIAL 63
+ T+ PAP N +G + ++Y + +++G+++ + GN VV ++
Sbjct: 50 SEVTASPAPTWDAPPDNASGCGE-QINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCF 108
Query: 64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTS 122
+ L+ +NYLI SLA+ DL V+V V+P ++ ++ KW G C++FIA+DV+CCT+
Sbjct: 109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTA 168
Query: 123 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRS 182
SI+ LC I++DRY IT P+ Y ++ + A +I WL+ I++PP+ GW ++ +
Sbjct: 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVN 226
Query: 183 DPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRH 242
D C IS+D GYTIYST AFYIP+ +ML +Y +I++AAR K+ A +
Sbjct: 227 DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR-----------KSAAKHKF 275
Query: 243 GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK 302
P +P + NG V+ EV E
Sbjct: 276 PGFPRVEP---------------------DSVIALNGIVK-----LQKEVEE-------- 301
Query: 303 EHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFF 362
CA S K+ER K RE+K TLGII+G F +CWLPFF
Sbjct: 302 -------------CANLSRLLKHER----KNISIFKREQKAATTLGIIVGAFTVCWLPFF 344
Query: 363 IVALVLPF-CESSCH-MPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
+++ PF C +SC +P + WLGY+NSL+NP IYA+FN+D + ++ +++C++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 219 bits (557), Expect = 5e-57
Identities = 137/429 (31%), Positives = 219/429 (51%), Gaps = 70/429 (16%)
Query: 3 VLSPGQGNNTTSP---PAPFETGGNTTG---ISDVTVSYQVI-TSLLLGTLIFCAVLGNA 55
V+ G G + S P GG+ G + + VS Q + + L I AV GN
Sbjct: 56 VVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNL 115
Query: 56 CVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIAL 115
V+ ++A R LQ V NY I +LAV DL++S VLP +A +VL W G+ CD++ A+
Sbjct: 116 LVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAV 175
Query: 116 DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW 175
DVLCCT+SIL LC I++DRY + + Y T R+AAA+++L W++ ++S+ P+LGW
Sbjct: 176 DVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGW 235
Query: 176 RTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEK 235
+ P D C I+++ GY ++S+ +FY+P+ +++V+Y R++ AR
Sbjct: 236 KEPVP-PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVAR------------ 282
Query: 236 TGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEV 295
S +R+ GV+ + G A + +R GAA
Sbjct: 283 ----------------------STTRSLEAGVKRERGKA--SEVVLRIHCRGAATGADGA 318
Query: 296 HRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFI 355
H + ++K H R++ + R + +RE+K KTL I++G F+
Sbjct: 319 HGMRSAKGH--------------------TFRSSLSVRLLKFSREKKAAKTLAIVVGVFV 358
Query: 356 LCWLPFFIVALVLPFCESSCHMPTLLGA--IINWLGYSNSLLNPVIYAYFNKDFQNAFKK 413
LCW PFF VLP + G +I WLGY NS +NP+IY +++F+ AF +
Sbjct: 359 LCWFPFF---FVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLR 415
Query: 414 IIKCKFCRQ 422
+++C+ CR+
Sbjct: 416 LLRCQ-CRR 423
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 214 bits (544), Expect = 2e-55
Identities = 125/392 (31%), Positives = 212/392 (54%), Gaps = 23/392 (5%)
Query: 35 YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAA 94
Y + +LL+ ++F GN V A++ E++LQ NYLI SLAV DL+V+ LV+P
Sbjct: 37 YATLLTLLIAVIVF----GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVV 92
Query: 95 LYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNK-RTPRRA 153
+V+ +W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+ Y + + RR
Sbjct: 93 YLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152
Query: 154 AALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213
+IS+ W++ F IS P + G + +D + C I+ + + +YS+ +FY+P ++ L+
Sbjct: 153 TVMISIVWVLSFTISCPLLFGL----NNADQNECIIA-NPAFVVYSSIVSFYVPFIVTLL 207
Query: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKK--------SVNGESGSRNWRL 265
+Y +I+ R R RK V + A H +P + + ++ S R
Sbjct: 208 VYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRY 266
Query: 266 GVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKN 325
+ L G + + G++K+H P ++ P R +
Sbjct: 267 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH-PKIAKIFEIQTMPNGKTRTS 325
Query: 326 ERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAII 385
+ ++RK++ +E+K + L I++G FI+CWLPFFI ++ C+ C++P +L +
Sbjct: 326 LKTM-SRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAF 382
Query: 386 NWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
WLGY NS +NP+IY FN +F+ AF KI+ C
Sbjct: 383 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 414
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 211 bits (536), Expect = 1e-54
Identities = 131/425 (30%), Positives = 213/425 (50%), Gaps = 60/425 (14%)
Query: 46 LIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLG 105
LI + GNA V+ A+ RSL+ N + SLA D++V+ L++P + ++L W
Sbjct: 22 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFR 81
Query: 106 QVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGF 165
+ C++++ALDVL CTSSI+HLCAI+LDRYWA++ ++Y +KRTPRR +I WLI
Sbjct: 82 RTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAA 141
Query: 166 LISIPPML--GWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR 223
+IS+PP++ G + P+ R P C ++++ Y + S+ G+F+ P L+M+++Y RI+ A
Sbjct: 142 VISLPPLIYKGDQGPQPRGRPQ-CKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIA- 199
Query: 224 FRIRKTVKKVEKTGADTRHGASPAPQP-------------------KKSVNGESGSRNWR 264
+++ ++ + G S P+P + VNG S S +
Sbjct: 200 ---KRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEK 256
Query: 265 LGVES----------KAGGALCANG-AVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGP 313
E+ + AL +G ++G GA+ E +E +A P
Sbjct: 257 EEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVP 316
Query: 314 ----TPCAPASFERKNERNAEA-------------------KRKMALARERKTVKTLGII 350
+ C+P + + R +R+ L RE++ L ++
Sbjct: 317 VSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVV 376
Query: 351 MGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNA 410
+G F+LCW PFF + C C +P L W+GY NS LNPVIY FN+DF+ A
Sbjct: 377 IGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRA 436
Query: 411 FKKII 415
F++I+
Sbjct: 437 FRRIL 441
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 210 bits (535), Expect = 2e-54
Identities = 154/462 (33%), Positives = 214/462 (46%), Gaps = 68/462 (14%)
Query: 1 MDVLSPGQGN---NTTSPPAPFETGGNTTGISDVTVSYQVITSL--LLGTLIFCAVLGNA 55
M L P GN N T P GG G S QV +L L G L+ V GN
Sbjct: 16 MGSLQPDAGNASWNGTEAP-----GG---GARATPYSLQVTLTLVCLAGLLMLLTVFGNV 67
Query: 56 CVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIAL 115
V+ A+ R+L+ N + SLA D++V+ LV+P + +V+ W G+ C++++AL
Sbjct: 68 LVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
Query: 116 DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW 175
DVL CTSSI+HLCAI+LDRYW+IT I+Y KRTPRR A+I W+I +IS PP++
Sbjct: 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISI 187
Query: 176 RTPEDRSDPD----ACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK 231
P C I+ Y I S G+F+ P L+M+++Y RI++ A+ R+T
Sbjct: 188 EKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAK---RRTRV 244
Query: 232 KVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQ-----GDD 286
+ G D A+P ++ NG R+ G NGA + D
Sbjct: 245 PPSRRGPDA--VAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRD 302
Query: 287 GAALEVIEVHRVGNSKEHLPLP-----SEAGP---------------------------- 313
AL++ E +S +H P E GP
Sbjct: 303 TDALDLEE----SSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIG 358
Query: 314 TPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCES 373
TP A ER A R RE++ L +++G F++CW PFF +
Sbjct: 359 TPAAGPGEERVGAAKASRWRGRQ-NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--- 414
Query: 374 SCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
C +P L W GY NS LNPVIY FN DF+ AFKKI+
Sbjct: 415 GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 209 bits (533), Expect = 3e-54
Identities = 134/411 (32%), Positives = 205/411 (49%), Gaps = 46/411 (11%)
Query: 24 NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83
N+TG S +L LI V GN V A+ ER+LQ NYL+ SLAV DL
Sbjct: 19 NSTGASQARP--HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76
Query: 84 MVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142
+V+ LV+P +V W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+
Sbjct: 77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPV 136
Query: 143 DY---VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYS 199
Y + + RR A +I+ W++ F +S P + G+ T DP C+IS + + IYS
Sbjct: 137 HYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSIS-NPDFVIYS 192
Query: 200 TFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASP----APQPKKSVN 255
+ +FY+P + +++Y RI+ + R RK + + + ++ P +P P
Sbjct: 193 SVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAH--- 249
Query: 256 GESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP 315
+E K ++C + A+ G G R G K + PT
Sbjct: 250 -----------LELKRYYSICQDTAL--GGPGFQ------ERGGELKREEKTRNSLSPTI 290
Query: 316 CAPASFERKNERNAEAKRKMALA---------RERKTVKTLGIIMGTFILCWLPFFIVAL 366
S E + N + L RE+K + + I++G FI+CWLPFF+ +
Sbjct: 291 APKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV 350
Query: 367 VLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
+ C+ +CH+ L + WLGY NS LNPVIY FN +F+ AF KI+ C
Sbjct: 351 LNTHCQ-TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 209 bits (533), Expect = 3e-54
Identities = 137/436 (31%), Positives = 221/436 (50%), Gaps = 82/436 (18%)
Query: 35 YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAA 94
Y + +LL+ ++F GN V A++ E++LQ NYLI SLAV DL+V+ LV+P
Sbjct: 37 YATLLTLLIAVIVF----GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVV 92
Query: 95 LYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNK-RTPRRA 153
+V+ +W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+ Y + + RR
Sbjct: 93 YLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRV 152
Query: 154 AALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213
+IS+ W++ F IS P + G + +D + C I+ + + +YS+ +FY+P ++ L+
Sbjct: 153 TVMISIVWVLSFTISCPLLFGL----NNADQNECIIA-NPAFVVYSSIVSFYVPFIVTLL 207
Query: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPA------PQPKKSVNGESGSRNWRLGV 267
+Y +I+ R R RK V + A H +P P+ K V
Sbjct: 208 VYIKIYIVLR-RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCT-----------V 255
Query: 268 ESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKE----------------HLPLPSEA 311
K+ G+ N R+ + + +E+ + ++ LP PS
Sbjct: 256 IMKSNGSFPVNR--RRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHH 313
Query: 312 G--PTPCAPASFERKNERNAEAK----------------------------RKMALARER 341
G TP +PA K E+N AK RK++ +E+
Sbjct: 314 GLHSTPDSPA----KPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEK 369
Query: 342 KTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYA 401
K + L I++G FI+CWLPFFI ++ C+ C++P +L + WLGY NS +NP+IY
Sbjct: 370 KATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLYSAFTWLGYVNSAVNPIIYT 427
Query: 402 YFNKDFQNAFKKIIKC 417
FN +F+ AF KI+ C
Sbjct: 428 TFNIEFRKAFLKILHC 443
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 203 bits (517), Expect = 2e-52
Identities = 130/404 (32%), Positives = 200/404 (49%), Gaps = 65/404 (16%)
Query: 24 NTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL 83
N+TG S +L LI V GN V A+ ER+LQ NYL+ SLAV DL
Sbjct: 19 NSTGASQARP--HAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL 76
Query: 84 MVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142
+V+ LV+P +V W ++ CD+F+ LDV+ CT+SIL+LCAI++DRY A+ P+
Sbjct: 77 LVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPV 136
Query: 143 DY---VNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYS 199
Y + + RR A +I+ W++ F +S P + G+ T DP C+IS + + IYS
Sbjct: 137 HYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSIS-NPDFVIYS 192
Query: 200 TFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASP----APQPKKSVN 255
+ +FY+P + +++Y RI+ + R RK + + + ++ P +P P
Sbjct: 193 SVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAH--- 249
Query: 256 GESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP 315
+E K ++C + A+
Sbjct: 250 -----------LELKRYYSICQDTALG--------------------------------- 265
Query: 316 CAPASFERKNERNAEAKRKMAL--ARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCES 373
P ER E E K + +L RE+K + + I++G FI+CWLPFF+ ++ C+
Sbjct: 266 -GPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQ- 323
Query: 374 SCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
+CH+ L + WLGY NS LNPVIY FN +F+ AF KI+ C
Sbjct: 324 TCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 199 bits (506), Expect = 4e-51
Identities = 133/386 (34%), Positives = 180/386 (46%), Gaps = 64/386 (16%)
Query: 41 LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN 100
LL+ ++ V GN V+ AIA LQ + N I SLA DL++ +LV+P A V
Sbjct: 63 LLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWG 122
Query: 101 KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT 160
+W G C+L+ ++DVLC T+SI LC IALDRY AIT P Y + T RA L+
Sbjct: 123 RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
Query: 161 WLIGFLISIPPML--GWRTPEDR-----SDPDACTISKDHGYTIYSTFGAFYIPLLLMLV 213
W I L+S P+L WR D +DP C + Y I S+ +FY+PL +M
Sbjct: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
Query: 214 LYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGG 273
+Y R+FR A +K VKK++ + R PA P S
Sbjct: 243 VYLRVFREA----QKQVKKID--SCERRFLGGPARPPSPS-------------------- 276
Query: 274 ALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKR 333
S P P P P A A+ A +R
Sbjct: 277 --------------------------PSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRR 310
Query: 334 --KMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYS 391
++ RE+K +KTLGIIMG F LCWLPFF+ +V F +P L NWLGY+
Sbjct: 311 PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHREL--VPDRLFVFFNWLGYA 368
Query: 392 NSLLNPVIYAYFNKDFQNAFKKIIKC 417
NS NP+IY + DF+ AF+ ++ C
Sbjct: 369 NSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 197 bits (500), Expect = 2e-50
Identities = 127/407 (31%), Positives = 204/407 (50%), Gaps = 77/407 (18%)
Query: 14 SPPAPFETGGNTTGISDVTVS------YQVITSLLLGTLIFCAVLGNACVVAAIALERSL 67
S P+P ET ++ G D+ S + V+ LLG L+ N V+A I R+
Sbjct: 13 STPSPLETN-HSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTF 71
Query: 68 QNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILH 126
V + L+ S+AV+D++V+ LV+P++ ++++ + W LG+ C L+IA DVLCCT+SI +
Sbjct: 72 HRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWN 131
Query: 127 LCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPML-GWRTPEDRSDPD 185
+ AIALDRYW+IT ++Y + + +I+LTW + +IS+ P+L GW +
Sbjct: 132 VTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEE 191
Query: 186 ACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGAS 245
C +S++ Y ++ST GAFY+PL ++L +Y ++I K K + G+ + S
Sbjct: 192 -CQVSREPSYAVFSTVGAFYLPLCVVLFVY--------WKIYKAAKF--RVGSRKTNSVS 240
Query: 246 PAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHL 305
P E +EV K+
Sbjct: 241 PIS------------------------------------------EAVEV------KDSA 252
Query: 306 PLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVA 365
P A +F+ + + E K E++ +GI++G F+LCW+PFF+
Sbjct: 253 KQPQMVFTVRHATVTFQPEGDTWREQK-------EQRAALMVGILIGVFVLCWIPFFLTE 305
Query: 366 LVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK 412
L+ P C SC +P + +I WLGYSNS NP+IY FNK++ +AFK
Sbjct: 306 LISPLC--SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 194 bits (494), Expect = 1e-49
Identities = 133/416 (31%), Positives = 204/416 (49%), Gaps = 32/416 (7%)
Query: 16 PAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVL-GNACVVAAIALERSLQNVANYL 74
PA + G + G++ Q +L+ G L+ AVL GN+ V ++A ER+LQ N
Sbjct: 18 PAAGASAGASAGLAG-----QGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSF 72
Query: 75 IGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTSSILHLCAIALD 133
I SLA DL++++LVLP+ +V W L CD +A+DV+ CT+SI +LCAI++D
Sbjct: 73 IVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVD 132
Query: 134 RYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDH 193
R+ A+ P+ Y + RR LI TWL+ ++ P + G R DP C + +D
Sbjct: 133 RFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR-DPAVCRL-EDR 190
Query: 194 GYTIYSTFGAFYIPLLLMLVLYGRIFRA-ARFRIRKTVK-----KVEKTGADTRHGASPA 247
Y +YS+ +F++P LML+LY FR R+ + + K +G PA
Sbjct: 191 DYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPA 250
Query: 248 PQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPL 307
P+ + G + G+ G CA A D + + L
Sbjct: 251 PRLPQDPCGPDCAPP-APGLPRGPCGPDCAPAAPSLPQDPCGPDC--------APPAPGL 301
Query: 308 PSEAGPTPCAPASFER-------KNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP 360
P + + CAP R + +R RERK ++ L +++G F+LCW P
Sbjct: 302 PPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTP 361
Query: 361 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK 416
FF+V + C +C +P L + + WLGY NS LNPVIY FN +F+N F+K ++
Sbjct: 362 FFVVHITQALC-PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALR 416
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 178 bits (451), Expect = 9e-45
Identities = 127/447 (28%), Positives = 210/447 (46%), Gaps = 49/447 (10%)
Query: 11 NTTSPPAPFETGGNTTGISDVTVSYQV-ITSLLLGTLIFCAVLGNACVVAAIALERSLQN 69
NT++PPA N T ++ +QV + G L V GN V+ + + L+
Sbjct: 2 NTSAPPA---VSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKT 58
Query: 70 VANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCA 129
V NY + SLA DL++ + + Y ++ W LG + CDL++ALD + +S+++L
Sbjct: 59 VNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLL 118
Query: 130 IALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWR--TPEDRSDPDAC 187
I+ DRY+++T P+ Y KRTPRRAA +I L WL+ F++ P +L W+ E C
Sbjct: 119 ISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQC 178
Query: 188 TIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT-RHGA 244
I T + AFY+P+ +M LY RI+R R R+ G++T G
Sbjct: 179 YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRAREL---AALQGSETPGKGG 235
Query: 245 SPAPQPKKSVNGESGS--------------------RNWRLGVESKAGGALCANGAVRQG 284
+ ++S G GS +W+ E G + +G
Sbjct: 236 GSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSS--EG 293
Query: 285 DDGAALEVIEVHRVG------------NSKEHLPLPSEAGPTPCAPASFERKNERNAEAK 332
++ + VI++ V +S + P++ G R E+ A+ +
Sbjct: 294 EEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAK-R 352
Query: 333 RKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSN 392
+ +L +E+K +TL I+ FIL W P+ I+ LV FC+ +P L + WL Y N
Sbjct: 353 KTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC--VPETLWELGYWLCYVN 410
Query: 393 SLLNPVIYAYFNKDFQNAFKKIIKCKF 419
S +NP+ YA NK F++ F+ ++ C++
Sbjct: 411 STINPMCYALCNKAFRDTFRLLLLCRW 437
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 173 bits (439), Expect = 2e-43
Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)
Query: 10 NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68
NN+T+ + N+ ++ +++V+ +L+ G+L ++GN V+ +I + R LQ
Sbjct: 2 NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
Query: 69 NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128
V NY + SLA DL++ V + + LY V+ W LG V CDL++ALD + +S+++L
Sbjct: 56 TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
Query: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182
I+ DRY+ +T P+ Y KRT + A +I+ W++ F++ P +L W RT ED
Sbjct: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
Query: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231
C I + T + AFY+P+++M VLY I RA++ RI+K K
Sbjct: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
Query: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280
++ K + + + K NG++ + N G E ++ + A
Sbjct: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
Query: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321
V DD + V +G+SK+ P PT +S
Sbjct: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
Query: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369
+ +E+ AK+K +RE+K +T+ I+ FI+ W P+ ++ L+
Sbjct: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
Query: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419
FC + C +P + I WL Y NS +NP YA N F+ FK ++ C +
Sbjct: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 173 bits (439), Expect = 2e-43
Identities = 112/387 (28%), Positives = 187/387 (48%), Gaps = 63/387 (16%)
Query: 40 SLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPM---AALY 96
+L + +I + GN V+ A+++E+ L N NY + SLA+ D++V +LV+P+ A LY
Sbjct: 57 ALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILY 116
Query: 97 QVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAAL 156
+ W L + C ++I+LDVL T+SI+HLCAI+LDRY AI +PI++ + +A
Sbjct: 117 DYV--WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMK 174
Query: 157 ISLTWLIGFLISIP-PMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLY 215
I++ W I +S+P P++G R E + + D + + +F AF+IPL +M++ Y
Sbjct: 175 IAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITY 234
Query: 216 GRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGAL 275
T+ + + HG + P
Sbjct: 235 -----------CLTIYVLRRQALMLLHGHTEEP--------------------------- 256
Query: 276 CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKM 335
G +L+ ++ + ++E + A P A +K ER +
Sbjct: 257 ----------PGLSLDFLKCCKRNTAEEE----NSANPNQDQNARRRKKKERRPRGTMQ- 301
Query: 336 ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCH---MPTLLGAIINWLGYSN 392
A+ ERK K LGI+ F++ W PFFI ++ CE SC+ M LL + W+GY
Sbjct: 302 AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFV-WIGYVC 360
Query: 393 SLLNPVIYAYFNKDFQNAFKKIIKCKF 419
S +NP++Y FNK ++ AF ++C +
Sbjct: 361 SGINPLVYTLFNKIYRRAFSNYLRCNY 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,601,233
Number of Sequences: 37866
Number of extensions: 731201
Number of successful extensions: 4058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 587
Number of HSP's successfully gapped in prelim test: 158
Number of HSP's that attempted gapping in prelim test: 2290
Number of HSP's gapped (non-prelim): 1406
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.