Search of human proteins with 55770888

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
         (1411 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]           2687   0.0  
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    253   1e-66
gi|21735548 centrosomal protein 2 [Homo sapiens]                      252   2e-66
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   246   1e-64
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   246   1e-64
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   245   2e-64
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   245   2e-64
gi|71061468 centromere protein E [Homo sapiens]                       244   4e-64
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   228   4e-59
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   223   8e-58
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   222   2e-57
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   221   4e-57
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    217   6e-56
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   217   6e-56
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   213   1e-54
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   213   1e-54
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   211   3e-54
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   211   3e-54
gi|55770834 centromere protein F [Homo sapiens]                       211   5e-54
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        210   7e-54
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               206   1e-52
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...   206   1e-52
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      205   3e-52
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   204   4e-52
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   204   5e-52
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  204   6e-52
gi|148746195 trichohyalin [Homo sapiens]                              201   4e-51
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    198   3e-50
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          197   6e-50
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          197   6e-50

>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 2687 bits (6964), Expect = 0.0
 Identities = 1411/1411 (100%), Positives = 1411/1411 (100%)

Query: 1    MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHY 60
            MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHY
Sbjct: 1    MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHY 60

Query: 61   EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
            EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ
Sbjct: 61   EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120

Query: 121  QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD 180
            QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD
Sbjct: 121  QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD 180

Query: 181  EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM 240
            EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM
Sbjct: 181  EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM 240

Query: 241  TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
            TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL
Sbjct: 241  TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300

Query: 301  TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
            TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL
Sbjct: 301  TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360

Query: 361  HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
            HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH
Sbjct: 361  HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420

Query: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
            SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ
Sbjct: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480

Query: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
            HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
            LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600

Query: 601  QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
            QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA
Sbjct: 601  QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660

Query: 661  QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720
            QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS
Sbjct: 661  QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720

Query: 721  LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
            LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI
Sbjct: 721  LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780

Query: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
            VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE
Sbjct: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840

Query: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
            LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900

Query: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
            LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN
Sbjct: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960

Query: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
            INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
            YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
            KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140

Query: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
            TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200

Query: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
            KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260

Query: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
            QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320

Query: 1321 DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNI 1380
            DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNI
Sbjct: 1321 DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNI 1380

Query: 1381 FCAECSAKNALTPSSKKPVRVCDACFNDLQG 1411
            FCAECSAKNALTPSSKKPVRVCDACFNDLQG
Sbjct: 1381 FCAECSAKNALTPSSKKPVRVCDACFNDLQG 1411


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  253 bits (645), Expect = 1e-66
 Identities = 326/1443 (22%), Positives = 640/1443 (44%), Gaps = 232/1443 (16%)

Query: 78   LALKRDDVTLLRQEVQDLQAS---LKEEKWYSE-----ELKKELEKYQGLQQQEAKPDGL 129
            L +K +++  LR  ++ +      L+E+K  SE     EL+K L   Q  ++   K   L
Sbjct: 377  LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK---L 433

Query: 130  VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEER--SLRE 187
              +   +++++E+  EE +             +Q+ +++  E+ D+  K  EE+   L++
Sbjct: 434  KAEMDEQIKTIEKTSEEERIS----------LQQELSRVKQEVVDVMKKSSEEQIAKLQK 483

Query: 188  AAEQKVTRLTEELNKEATV----IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
              E+++ R  +EL K+        Q+     L++   E + + +++  Q    ++ + L+
Sbjct: 484  LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543

Query: 244  RERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQE-------VAVYVQ-ELQKLKS 295
            ++    + +++ + LQ +  +    I +L S L K  QE       +AV+++ E  K   
Sbjct: 544  KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603

Query: 296  SVNELTQKNQTLTENL-------------LKKEQDYTKLE------EKHNEESVSKKNIQ 336
             +  + +K++T  E+L             + K+Q  T++E      E+  E  +  K I 
Sbjct: 604  EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663

Query: 337  ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS-----------EVE 385
               H ++++ + L+ +L   +T L  +  ELSE  +A  KL+EELS           E+E
Sbjct: 664  FQAHIEEMNEKTLE-KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722

Query: 386  TKYQH--------------------------LKAEFKQLQQQREEKEQHGLQLQSEINQL 419
             K                             LK +  QL+   +E+++H  + Q+ +  L
Sbjct: 723  AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782

Query: 420  HSKLLETERQLGEAHGRLK----------EQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
             + +  +E +L +A  +L           EQ +   E+L   +Q++ DL+ +   L +Q+
Sbjct: 783  EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842

Query: 470  KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR---QIGDKDQKIQ 526
             E      ++  +LD  K Q Q+     +   +++ +    L QV     + G+K+Q+ Q
Sbjct: 843  AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE-Q 901

Query: 527  NLEALLQKSKENISLLE---KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
              + L++K    + + E   KE E L  K+ A E    +LN+  E     QE+      K
Sbjct: 902  TKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK------K 955

Query: 584  LKNQSESHKQAQENLHDQVQEQKAHLRAA-QDRVLSLETSVNELNSQLNES--------K 634
            ++   +  K+ QE L  ++ +Q+A L+   ++  L L     + N+++ E          
Sbjct: 956  MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015

Query: 635  EKVSQLDI----QIKAKTEL-------LLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
            + VS+L+     QI++ TE+       ++S    K  Q+A+    +   Q  LQ+K+QE+
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ--LQEKEQEV 1073

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
             ++  ++     + ++  +  + L+    +       L+++ ++    +  L  D  ++K
Sbjct: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133

Query: 744  ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
            A  E+   DL +  + NT L+ +  EL    E +K  VS     L+   E  +S+K    
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193

Query: 804  KQEEEKQILKQDFETLSQETKIQHE----ELNNRIQTTVTELQKVKMEK-EALMTELSTV 858
            K  +  +    +F+ LS+E  IQ +    +    ++    EL  +   K  A+++ +S  
Sbjct: 1194 KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253

Query: 859  KDKLSKVSDSL---KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
            + + +KV ++L     + SE E + ++       L  + ++  HQL+ + EN +K  K  
Sbjct: 1254 QHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE-EKENQIKSMKAD 1312

Query: 916  KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
             +SL  EKEA   L+ E  + Q+   + ++ + Q +KE  +    +  +K+  ++KK +I
Sbjct: 1313 IESLVTEKEA---LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI 1369

Query: 976  EALQGEL---------KIAVLQKTELENKLQQQLTQAAQEL------------AAEKEKI 1014
             +L  +L          I++ +K    + L++Q  +   EL               KEKI
Sbjct: 1370 SSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429

Query: 1015 SVLQNNYE---KSQETFKQLQSDFYGRESEL--LATRQDLKSVEEKLSLAQEDLISNRNQ 1069
            S L+   +   K  E  K+ QS F   ++ +  L  + +LKS E      Q +L+  + +
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL--KEE 1487

Query: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
            +  QNK    L   K  +E D +K E              K++S  E EL ++ +++ E+
Sbjct: 1488 LDQQNKRFDCL---KGEMEDDKSKME--------------KKESNLETELKSQTARIMEL 1530

Query: 1130 EEIKCRQEKEITKLNEELKSH-------------KLESIKEITNLKDAKQLLIQQK-LEL 1175
            E+   ++  EI  LNE LK++             KL+  +E+   KD +    ++K L L
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590

Query: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK-KHEE 1234
            + +  S+KA +E +K+  + +   VK +EEELK      E +L SE   K   +K K E+
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELK----ALEDRLESESAAKLAELKRKAEQ 1646

Query: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE---ATVQNNQDE 1291
              A +  Q+ +  E      K  + ++  +SEL  +  +   E+ +LE    +V+++Q E
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYK--KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704

Query: 1292 RRALLERCLK------------GEGEIEK-LQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
               ++ R  K             +G ++K  + K+  LQR L      +Q +G+E +   
Sbjct: 1705 -TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763

Query: 1339 IKH 1341
              H
Sbjct: 1764 SSH 1766



 Score =  206 bits (525), Expect = 1e-52
 Identities = 304/1429 (21%), Positives = 612/1429 (42%), Gaps = 239/1429 (16%)

Query: 82   RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG-LQQQEAKPDGLVTDSSA---EL 137
            +D +  L   +++    LKE + + E L+ ++++ +G LQQ  AK D   +  SA   + 
Sbjct: 755  KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT 814

Query: 138  QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
            ++ E+QL + Q +  +++  + L  ++ A++  +  D+ ++ D       A + +V  L 
Sbjct: 815  KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELD-------AHKIQVQDLM 867

Query: 198  EELNKEATVIQDLKTELLQ--RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
            ++L K+ + ++     L Q     +ED    +++  Q+    +NM L+     E  K E 
Sbjct: 868  QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR---EGQKKEI 924

Query: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
            + L  + ++ E +I  L  E     +     ++++++    + E  +K     E  LKKE
Sbjct: 925  EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984

Query: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA-T 374
             + T LE    E+  + K ++             Q+  +    ++ R+     E+ E+ T
Sbjct: 985  LENTALELSQKEKQFNAKMLEMA-----------QANSAGISDAVSRLETNQKEQIESLT 1033

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREE-KEQHGLQLQS---EINQLHSKLL----ET 426
            +  + EL++V + ++      K+L QQ EE +E H +QLQ    E+ +L  K+L    E 
Sbjct: 1034 EVHRRELNDVISIWE------KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087

Query: 427  ERQLGEAH-------------GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
            E    E                 L+EQ +  S  +    Q    L+  L +LE  L + +
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147

Query: 474  TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL-------RQIGDKDQKIQ 526
              +T LQ QL + K   +E +      T+KL+    + + +        + + DK  + +
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207

Query: 527  NL---------------EALLQ-KSKENISLLEKEREDLYAKIQAGEGET---------- 560
             L               EALL+ K+ E I++   +   + ++I   +  T          
Sbjct: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267

Query: 561  --------AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
                    A L QL E+ +TL     Q T +L+ +    K  + ++   V E++A  +  
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327

Query: 613  ---QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
               Q      E+ + +L  +L+E+   V+ +  ++K K   + S     T     LQN +
Sbjct: 1328 GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387

Query: 670  DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
                 +L +K+  ++ +  Q D+   +L D+ +  S     L   KEK  +LEQ  ++  
Sbjct: 1388 -----SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS--KEKISALEQ-VDDWS 1439

Query: 730  GQIKKLEADSLEVKASKEQALQDLQQQRQLNT--------DLELRATELSKQ-------- 773
             +  + +  +       +  +++LQ Q +L +         + L   EL +Q        
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 774  -------LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
                    +MEK+  S+   +L+ ++  +  ++  +T++  E + L +  +  +Q+  I+
Sbjct: 1500 GEMEDDKSKMEKK-ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558

Query: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
            H+EL  ++Q      Q++  EK+  + E    ++K+  + + + + K+E E +       
Sbjct: 1559 HKELVQKLQ----HFQELGEEKDNRVKE---AEEKILTLENQVYSMKAELETKK------ 1605

Query: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL-ELNSMQEQLIQA-- 943
                    KEL+H     +  ++K ++E  K+LE   E+    KL EL    EQ I A  
Sbjct: 1606 --------KELEH-----VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK 1652

Query: 944  -QNTLKQNEKEEQQLQGNINELKQSS-------------EQKKKQIEALQGELKIA---- 985
             Q   +  EKEEQ  +G  + L + +             E+K K +E+ Q E  I     
Sbjct: 1653 KQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSA 1712

Query: 986  --VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
              V   TE E    Q   Q   E     EKISVLQ N  + ++  +++  +     S   
Sbjct: 1713 KNVAAYTEQEEADSQGCVQKTYE-----EKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767

Query: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL------EQDSAKKEQQ 1097
              R   +    KL  A+     +++ IG+  + ++E K  K +L      E++  K   Q
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQ 1826

Query: 1098 LQERCKALQDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
             ++  + + D   +K+L+EKEL  +  + K+ E++    RQ KE+ ++  E  + K E +
Sbjct: 1827 AKQNLENVFD-DVQKTLQEKELTCQILEQKIKELDSCLVRQ-KEVHRVEMEELTSKYEKL 1884

Query: 1156 KEITNL---------------KDAKQLLIQQKL--ELQGKADSLKAAVEQEKRNQQILKD 1198
            + +  +               + +K  L+Q KL   ++ + + L+  +   +R +Q L  
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944

Query: 1199 QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
            ++ + +++L+   + KE +   EI +KE   ++ E+ + +        N  L  + +E+ 
Sbjct: 1945 EIVRLQKDLR--MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFN 2002

Query: 1259 SS-QRRVSELEKQTDDLRGEIAVLEATV-QNNQDERRALLERCLKGEGEIEK-------- 1308
            +   ++  ELE    +   +   +EA + +++Q+E   LL++  + + ++++        
Sbjct: 2003 TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEI 2062

Query: 1309 --------------LQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343
                          LQT++ ELQ+K        +  G +N ++    TQ
Sbjct: 2063 LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQ 2111



 Score =  198 bits (504), Expect = 3e-50
 Identities = 267/1146 (23%), Positives = 492/1146 (42%), Gaps = 175/1146 (15%)

Query: 75   ESNLALKRDDVTLLRQEVQ----DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
            E  L  K  +V  L+Q++     + +   KE  W  EE  K+      LQ+Q  +    V
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV 1122

Query: 131  TDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
               + +   L+  LE+ + + N ++K+   L EQ                 E + L E  
Sbjct: 1123 NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV---------------ELKMLAEED 1167

Query: 190  EQKVTRLTEELNKEATVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTL-MDNMTLERERE 247
            ++KV+ LT +L       Q LK+   +    +ED ++  K+L +   + +D    + E  
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227

Query: 248  SEKLKDECKKLQSQYASSEAT-ISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
             E   +E   + S   ++  + IS  +    K  + + +    + +L++ + +LT++  T
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287

Query: 307  LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL---DCQQLQSRLSASETSLHRI 363
            L    +  +Q   +LEEK N+    K +I++ + +K+    +    Q   S  E+ + ++
Sbjct: 1288 LN---ISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344

Query: 364  HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
              ELSE   A   +KEEL E + +   L  +   L           +QLQ+ I+      
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN----------VQLQNSIS------ 1388

Query: 424  LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
                  L E    +   R+   E+  +   QV DL  K+  L ++    +    +  ++ 
Sbjct: 1389 ------LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442

Query: 484  DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
             + K++ Q +    Q+T   ++E Q  LE   ++  +KD++I  L+  L +  +    L+
Sbjct: 1443 SEWKKKAQSRFTQHQNT---VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 544  KEREDLYAKIQAGEG--ETAVLNQ----LQEKNHTLQE--QVTQLTEKLKNQSES----H 591
             E ED  +K++  E   ET + +Q    ++ ++H  Q+  ++  L E LKN ++     H
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559

Query: 592  KQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
            K+  + L    +  +E+   ++ A++++L+LE  V  + ++L   K+++  +++ +K+K 
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE 1619

Query: 649  ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-L 707
            E L + E    ++         +A    + K++   KI     Q+ +++++K+E   +  
Sbjct: 1620 EELKALEDRLESE---------SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670

Query: 708  ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE----------VKASKEQALQDLQQQR 757
            ESHL E   K    E++   LE ++K +E+   E          V A  EQ   D Q   
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730

Query: 758  QLNTD-----LELRATELSKQLE---MEKEIVSSTRLDLQ-KKSEALESIKQKLTKQEEE 808
            Q   +     L+   TE  K L+    EKE   S+  +++ +  E L  ++    KQ E+
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790

Query: 809  KQILKQDFETLSQETK---------IQHEELNNRIQT------TVTELQKVKMEKEALMT 853
            + ++    E L ++ K         ++ E   N IQ          ++QK   EKE    
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850

Query: 854  ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
             L   + K+ ++   L   K     E +         E T K  K Q   QM+   K  +
Sbjct: 1851 IL---EQKIKELDSCLVRQKEVHRVEME---------ELTSKYEKLQALQQMDGRNKPTE 1898

Query: 914  ELKKSLEKEKEASHQLKLELNSMQE----------------------QLIQAQNTLKQNE 951
             L+++ E EK  SH ++ +L S  E                      ++++ Q  L+   
Sbjct: 1899 LLEENTE-EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957

Query: 952  KEEQQ-LQGNINELKQSSEQKKKQ------------IEALQGELKIAVLQKT-ELENKLQ 997
            KE QQ L+    E  Q  E+K KQ            ++ L  E    + QK  ELE  ++
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017

Query: 998  QQLTQAAQELAAE------KEKISVLQNNYEKSQE---TFKQLQSDFYGRESELLATRQD 1048
            + + +A QE+ AE      +E   +L+   EK  +   T K+ +     RE E+ A  +D
Sbjct: 2018 ETINKA-QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD 2076

Query: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT---AKATLEQDSAKKEQQLQERCKAL 1105
            L++  E+L    +  +      GN N  I EL+T    K TL  DS  KEQ+ +E+   L
Sbjct: 2077 LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136

Query: 1106 QDIQKE 1111
            +D  K+
Sbjct: 2137 EDRLKK 2142



 Score =  195 bits (496), Expect = 2e-49
 Identities = 297/1372 (21%), Positives = 583/1372 (42%), Gaps = 194/1372 (14%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            E+   L    V  +  + +D+   L   K   ++L ++LEK     +Q+ K    V +S 
Sbjct: 832  ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891

Query: 135  AELQSLEQ---------------QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY 179
             E  + EQ               Q+ E Q +   I   K   ++ +  +  E  + K K 
Sbjct: 892  LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN 951

Query: 180  DE---ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ-------------------R 217
             E   E+  ++A E + T   + L++EA + ++L+   L+                    
Sbjct: 952  QEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011

Query: 218  PGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELA 277
             GI D AV + E  Q + + +++T    RE   +    +K  +Q A     I ++  +L 
Sbjct: 1012 AGISD-AVSRLETNQKEQI-ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEI--QLQ 1067

Query: 278  KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV------- 330
            +  QEVA   Q++        E+ ++   L E  +K++    +L+E+  ++S        
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127

Query: 331  SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
             +  ++A L + ++D  +     +  +  L  + +   E      +L  +L   + ++Q 
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187

Query: 391  LKAEFKQLQQQREEKEQHGLQLQSEIN-QLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
            LK+  ++  +  E+K     +L  E+  QL     +TE  L     +  E   +SS K  
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL---EAKTNELINISSSKTN 1244

Query: 450  DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
                +++  Q + ++++E L  K    +EL+ QL +  ++        Q  T +L E +N
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304

Query: 510  DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE-----TAVLN 564
             ++ +   I    + +   +  LQK   N      E+E    +++    E     T +  
Sbjct: 1305 QIKSMKADI----ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360

Query: 565  QLQEKN---HTLQEQVTQLTEKLKNQ-SESHKQAQ-ENLHDQVQEQKAHLRAAQDRVLSL 619
            +L+EK     +L +Q+T L  +L+N  S S K+A   +L  Q  E+K  L    D+V  L
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL---LDQVQDL 1417

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
               V+ L      SKEK+S L+                           +D   N   + 
Sbjct: 1418 SFKVDTL------SKEKISALE--------------------------QVDDWSNKFSEW 1445

Query: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
            +++     TQ      +LQ       QLE   KE  EK   +    EEL+ Q K+ +   
Sbjct: 1446 KKKAQSRFTQHQNTVKELQ------IQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499

Query: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
             E++  K +      ++++ N + EL+ ++ ++ +E+E  I   T ++++  +E L++  
Sbjct: 1500 GEMEDDKSK-----MEKKESNLETELK-SQTARIMELEDHITQKT-IEIESLNEVLKNYN 1552

Query: 800  QKLTKQEEEKQILK--QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
            Q+  K  E K++++  Q F+ L +E   + +E   +I T   ++  +K E E    EL  
Sbjct: 1553 QQ--KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610

Query: 858  VKDKLSKVSDSLKNSKSEFEKENQKGKAAI-LDLEKTCKELKHQLQVQMENTLKEQKELK 916
            V   +    + LK  +   E E+    A +    E+    +K QL  QME   +++++ K
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQME---EKEEQYK 1667

Query: 917  KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
            K  E     SH            L +    L++ E+E   L           E+K K +E
Sbjct: 1668 KGTE-----SH------------LSELNTKLQEREREVHIL-----------EEKLKSVE 1699

Query: 977  ALQGELKIA------VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
            + Q E  I       V   TE E    Q   Q   E     EKISVLQ N  + ++  ++
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE-----EKISVLQRNLTEKEKLLQR 1754

Query: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL--- 1087
            +  +     S     R   +    KL  A+     +++ IG+  + ++E K  K +L   
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVA 1813

Query: 1088 ---EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITK 1142
               E++  K   Q ++  + + D   +K+L+EKEL  +  + K+ E++    RQ KE+ +
Sbjct: 1814 QHVEKEGGKNNIQAKQNLENVFD-DVQKTLQEKELTCQILEQKIKELDSCLVRQ-KEVHR 1871

Query: 1143 LNEELKSHKLESIKEITNL---------------KDAKQLLIQQKL--ELQGKADSLKAA 1185
            +  E  + K E ++ +  +               + +K  L+Q KL   ++ + + L+  
Sbjct: 1872 VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931

Query: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
            +   +R +Q L  ++ + +++L+   + KE +   EI +KE   ++ E+ + +       
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLR--MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989

Query: 1246 LNENLGTVKKEWQSS-QRRVSELEKQTDDLRGEIAVLEA-TVQNNQDERRALLERCLKGE 1303
             N  L  + +E+ +   ++  ELE    +   +   +EA  ++++Q+E   LL++  + +
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049

Query: 1304 GEIEKLQTKVLE-LQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNE 1354
             ++++   +  E L  + +  TA V++L  + + LQ K+ Q L ++    N+
Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND 2101



 Score =  187 bits (474), Expect = 8e-47
 Identities = 294/1325 (22%), Positives = 574/1325 (43%), Gaps = 177/1325 (13%)

Query: 155  KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL-----NKEATVIQD 209
            K++K    ++  QL   +A  ++  +     R     + +  TE+L     N+E+   Q 
Sbjct: 3    KKLKQKISEEQQQLQQALAPAQASSNSSTPTR--MRSRTSSFTEQLDEGTPNRESGDTQS 60

Query: 210  LKTEL-LQRPGIEDV--AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
               +L L+ P +E +  + +K+ L +  +  +++     RES    D    L S  AS +
Sbjct: 61   FAQKLQLRVPSVESLFRSPIKESLFRSSS-KESLVRTSSRESLNRLD----LDSSTASFD 115

Query: 267  ATISQLRSELAKGPQEVAVYVQELQKLKSSVN--ELTQKNQTLTENLLKKEQDYTKLEEK 324
                         P ++    ++L     S+N  +L Q+ + +  +L      Y++L   
Sbjct: 116  P------------PSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTA 163

Query: 325  HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
            +      KK +Q  L Q             + + SL RI            +L+EEL   
Sbjct: 164  YQMLQREKKKLQGILSQ-------------SQDKSLRRI-----------AELREELQMD 199

Query: 385  ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
            +   +HL+ EF       EEK+Q+   LQ++++ L  +L      +      LK   QL 
Sbjct: 200  QQAKKHLQEEF---DASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV----LKPLPQLE 252

Query: 445  SE-KLMDKEQQ-------VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
             + ++  KE+        V +    +  LE  L+++V     L  +  +T Q H+EQ  L
Sbjct: 253  PQAEVFTKEENPESDGEPVVEDGTSVKTLET-LQQRVKRQENLLKRCKETIQSHKEQCTL 311

Query: 497  QQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
              S    L+E  ++  Q L +I D    +   L   L+ +K  I  LE+++  + A+ + 
Sbjct: 312  LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLT---EKLKNQSE-SHKQAQENLH------DQVQEQ 605
               ET  L   +E+   L+ ++ Q+T   E+L+ Q E S + A E L        + +E 
Sbjct: 372  QMHET--LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429

Query: 606  KAHLRAAQD-RVLSLETSVNELNSQLNESKEKVSQ--LDIQIK------AKTELLLSAEA 656
            +  L+A  D ++ ++E +  E    L +   +V Q  +D+  K      AK + L   E 
Sbjct: 430  RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL 489

Query: 657  AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
            A+  Q  +L   L T +   Q+ Q ++    +Q + +    + +Q+    LE    + K 
Sbjct: 490  ARKEQ--ELTKKLQTREREFQE-QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546

Query: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD-LQQQRQLNTDLELRATELSKQLE 775
                 E K  +L+ + +      LE+++S E++LQ+   Q + L   LE    + +K++ 
Sbjct: 547  ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606

Query: 776  MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK------QDFETLSQETKI---- 825
            +  E   +    L+ + +AL + K ++ KQ+ + ++ K      Q+ ETL ++ +I    
Sbjct: 607  VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666

Query: 826  QHEELNNR-----------IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
              EE+N +           +++  +EL +V   +  L  ELS +KD+  K+   L+    
Sbjct: 667  HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD 726

Query: 875  EFEKENQKGKAAIL-----DLEKTCKELKHQLQVQMENTLKEQ-----------KELKKS 918
            E +  +Q+   +I+      +++T K LK Q+  Q+E  LKE+           + L+  
Sbjct: 727  EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN-QLELLLKERDKHLKEHQAHVENLEAD 785

Query: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
            +++ +    Q   +L+  Q          K  E++  QLQ  + +L+       KQ+  +
Sbjct: 786  IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845

Query: 979  QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE-------KSQETFKQL 1031
            + + K    +    + ++Q  + Q  ++ +  ++K+  L   YE       K QE  KQ+
Sbjct: 846  EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905

Query: 1032 QSD--------FYGRESELLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQELKT 1082
              +          G++ E+    Q L + E+ + +  E+  +  +NQ     K+ Q+ K 
Sbjct: 906  LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKE 965

Query: 1083 AKATLEQDSAKKEQQLQERCK--ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
             + TL++    +E +L++  +  AL+  QKEK    K L   ++  A I +   R E   
Sbjct: 966  MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ 1025

Query: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE--KRNQQIL-- 1196
             +  E L       + ++ ++ + K  L QQ  ELQ   +      EQE  +  Q+IL  
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKK--LNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083

Query: 1197 ---KDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
               K+++ KE   LK+E ++++    +L  ++K+K   +    ++E KL   +  L  +L
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143

Query: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
                KE    Q ++ EL+   ++ + +++ L + ++   +E ++L     K    +E   
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203

Query: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVR 1370
             +  +L  +L     A+Q        +  K T+AL    A+ NE+ N ++  K  ++  R
Sbjct: 1204 LEFKKLSEEL-----AIQ------LDICCKKTEALLE--AKTNELIN-ISSSKTNAILSR 1249

Query: 1371 RHHCR 1375
              HC+
Sbjct: 1250 ISHCQ 1254



 Score =  146 bits (368), Expect = 2e-34
 Identities = 194/853 (22%), Positives = 371/853 (43%), Gaps = 99/853 (11%)

Query: 81   KRDDVTLLRQEVQD-------LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
            K   +T L++E+ +       ++  LKE+K     L K+L       Q        +++ 
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS----LSEK 1392

Query: 134  SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
             A + SL +Q +E + E  +  Q++DL  +       +I+ ++   D      E  ++  
Sbjct: 1393 EAAISSLRKQYDEEKCELLD--QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450

Query: 194  TRLTEELN--KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
            +R T+  N  KE  +  +LK++       E + +LK+EL Q     D +  E E +  K+
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKD-EQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509

Query: 252  KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
            + +   L+++  S  A I +L   + +   E+       + L   +    Q+     + L
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEI-------ESLNEVLKNYNQQKDIEHKEL 1562

Query: 312  LKKEQDYTKL-EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
            ++K Q + +L EEK N    +++ I    +Q       +++ L   +  L  +++ +  K
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQ----VYSMKAELETKKKELEHVNLSVKSK 1618

Query: 371  GEATQKLKEEL-SEVETKYQHLKAEFKQ---------LQQQREEKEQHGLQLQSEINQLH 420
             E  + L++ L SE   K   LK + +Q         L Q  E++EQ+    +S +++L+
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678

Query: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDK----------EQQVADLQLKLSRL-EEQL 469
            +KL E ER++     +LK      SE L+            EQ+ AD Q  + +  EE++
Sbjct: 1679 TKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKI 1738

Query: 470  KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
                 N TE +  L +  Q+ +E  +       + +E    LE    +  +    I +L+
Sbjct: 1739 SVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798

Query: 530  ALLQKSKENISLL-----EKE--REDLYAKIQAGEGETAVLNQLQEKNHT---LQEQVTQ 579
              L++  +  SL+     EKE  + ++ AK         V   LQEK  T   L++++ +
Sbjct: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKE 1858

Query: 580  LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639
            L   L  Q E H+   E L  + ++ +A         L      N+    L E+ E+ S+
Sbjct: 1859 LDSCLVRQKEVHRVEMEELTSKYEKLQA---------LQQMDGRNKPTELLEENTEEKSK 1909

Query: 640  LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699
              +    + +LL + EA    Q  DL+  L  A+   Q   +E+ ++   L  +      
Sbjct: 1910 SHL---VQPKLLSNMEA----QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML------ 1956

Query: 700  KQEHCSQLESHLKEY-KEKYLSLEQKTEELE----GQIKKLEADSLEVKASKEQALQDLQ 754
            ++EH  +LE   KEY +E+   ++Q+ E+LE      +K+L  +     A KEQ L+ + 
Sbjct: 1957 RKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE-MT 2015

Query: 755  QQRQLNTDLELRATELSKQLEMEKEI---VSSTRLDLQKKSEALESIKQKLTKQEEEKQI 811
             +  +N   E+ A  L    E   ++   ++    DL++ ++  E I   L  +EEE   
Sbjct: 2016 IKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEI---LDAREEEMTA 2072

Query: 812  LKQDFETLSQET------KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
              +D +T  +E       K++ EE       T+ ELQ    +K  L+++    + +  + 
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132

Query: 866  SDSLKNSKSEFEK 878
              +L++   ++EK
Sbjct: 2133 IHNLEDRLKKYEK 2145


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  252 bits (644), Expect = 2e-66
 Identities = 305/1392 (21%), Positives = 627/1392 (45%), Gaps = 212/1392 (15%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            E   A    +V  LR++ +      KE  W+ +EL K LE    L++++ + +  + +  
Sbjct: 845  EQQKAAHEKEVNQLREKWE------KERSWHQQELAKALES---LEREKMELEMRLKEQQ 895

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAA--------QLATEIADIKSKYDE----- 181
             E+++++ Q EE +T+  +      L  +K          Q   E+AD   + +      
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 182  ---------------------ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
                                 +R L+EAA Q    L     + ++++QD K +L ++  +
Sbjct: 956  KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD-KMDLQKQ--V 1012

Query: 221  EDVAVLKKELV---QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL- 276
            ED   LK +LV     Q L++    E+ RE+++     K+L+ + AS   ++ +    L 
Sbjct: 1013 ED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069

Query: 277  ------AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEE-- 328
                  +   QE++   Q++Q+ +    EL+ + + L + + +KE D+   E +  EE  
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129

Query: 329  --SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET 386
               ++++ ++A+L  ++    QLQ RL ++E+ L  +  E     +A  +     +++ +
Sbjct: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ-----AQLAS 1184

Query: 387  KYQHLKAEFKQLQQQREE---------------KEQHGLQ----------------LQSE 415
             Y  L+     + + R E                +Q+G +                + S 
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244

Query: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
            +++LH  L +T+    +    L++Q Q   E+L D E + + +  +L  L+ QL      
Sbjct: 1245 LHKLHQDLWKTQ----QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS----- 1295

Query: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
                Q+Q +K+K + ++     +S   +L E    L+  LR+   +  + Q    LLQ +
Sbjct: 1296 ----QNQEEKSKWEGKQNSL--ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349

Query: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS-ESHKQA 594
            KEN++    + E L A +     + +    L+E   T +  +     KLKN+  ES ++ 
Sbjct: 1350 KENLTA---QVEHLQAAVVEARAQASAAGILEEDLRTARSAL-----KLKNEEVESERER 1401

Query: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI---KAKTELL 651
             + L +Q + + A  +A Q+ +  L  ++ E   ++   + ++ +L+ Q    KA  ELL
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461

Query: 652  LSAEAAKTAQRADLQNH-----------LDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
             S +  K  Q  DLQ             L+    A+Q+++Q   K+T Q +Q+    +D+
Sbjct: 1462 -SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ---KLTVQREQIRELEKDR 1517

Query: 701  QEHCSQLESHLKEYKEKYLSLEQK---TEELEGQIKKLEADSLEVKAS------KEQALQ 751
            +   + LE  L E ++K   +E +    ++L+ Q+  LE  +LE++ +      +++ ++
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577

Query: 752  DLQQQRQ--------LNTDLELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQ 800
            +L+ QR+        L  DLE R+ EL  Q     ++ S + +   +LQ++ + ++S ++
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
            ++ + + +K+ L QD E   QE  +Q E    RIQ  V E Q+ +  K  L  +L  +K 
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKE----RIQ--VLEDQRTRQTK-ILEEDLEQIKL 1690

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
             L +    L   +   ++  ++GK       K  +     +++ + +  KE +  ++ + 
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGP----SKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
            + +E   QL+ +L  +  ++ +    L Q E+E   LQ  + E ++  E K++ +++   
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806

Query: 981  ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
            E + A+ Q+ +    LQQ+  QA  +    KEK   LQ   E++  T K+       R  
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE-------RHG 1859

Query: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
            EL   ++  + +EE+L++    + +    +G+     +E + A   L+Q  A++ Q+ + 
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919

Query: 1101 RCKALQD--IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158
              +ALQD  +Q +  LKE++         E+E +  R E + ++  EE    + E+++E 
Sbjct: 1920 ETRALQDSWLQAQAVLKERD--------QELEAL--RAESQSSRHQEEAARARAEALQEA 1969

Query: 1159 TN-----LKDAKQLLIQQ---KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
                   L+  +Q L++Q      L+    +L+A+++  + + + L++ ++ +E E++ +
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029

Query: 1211 ---FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL--------NENLGTVKKEWQ- 1258
               + E   +L   + +++  ++  +E E  L   +            +NLG  ++E + 
Sbjct: 2030 DLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEI 2089

Query: 1259 -SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317
                + V EL+        EI  L  T Q N  E      +    E +  KL +    LQ
Sbjct: 2090 RGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ 2149

Query: 1318 RKLDNTTAAVQE 1329
            R+L+   AA+++
Sbjct: 2150 RELERLQAALRQ 2161



 Score =  229 bits (584), Expect = 1e-59
 Identities = 321/1396 (22%), Positives = 604/1396 (43%), Gaps = 157/1396 (11%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKPDGLVT 131
            +S L  + D   L+ QEVQ+    L+E + Y+  ++KELE+ +    L   E +   LV 
Sbjct: 1016 KSQLVAQDDSQRLVEQEVQE---KLRETQEYNR-IQKELEREKASLTLSLMEKEQRLLVL 1071

Query: 132  DSS-----AELQSLEQQLEEAQTENFNIKQMKDLFEQKA--------AQLATEIADIKSK 178
              +      EL +L Q ++EAQ E   +    +L  Q+         AQ A  + ++++ 
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131

Query: 179  YDEERSLRE---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT 235
            +  E+ LR    A E K  +L   L    + ++ L  E  Q+PG +  A  + +L  + +
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQ--AQAQAQLASLYS 1187

Query: 236  LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
             +            +L        S +   E   +  RS   +GP   A+  + +     
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGL-EPDQNGARSLFKRGPLLTALSAEAVASALH 1246

Query: 296  SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
             +++   K Q   + L  + Q   KLEE+  +    K  +   L        Q Q   S 
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQ---KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK 1303

Query: 356  SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
             E   + +  EL E  E    L+  L   E +    + E + LQ  +E        L ++
Sbjct: 1304 WEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN-------LTAQ 1356

Query: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
            +  L + ++E   Q   A G L+E  + +   L  K ++V   + +   L+EQ + KV  
Sbjct: 1357 VEHLQAAVVEARAQASAA-GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415

Query: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREA--QNDLEQVLRQIGDKDQKIQNLEALLQ 533
               LQ  L    Q   E++   ++   +++E   Q ++++   ++   D K +N E  LQ
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475

Query: 534  KSKENISLLEKER---EDLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSE 589
            +  E I  LEK R   E L   +Q  E +  V   Q++E     + Q   L  +L  + E
Sbjct: 1476 Q--EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL-ELE 1532

Query: 590  SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
               Q  E+   QVQ+ K  L   +   L LE + +++  Q    KE   Q + Q  A T 
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592

Query: 650  LLLSAEA------AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703
            L L  E       A+++Q  DL++H       LQ++ QE+     Q+++    LQ ++EH
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE----LQRQKEH 1648

Query: 704  CSQ-LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
             +Q LE   +E   +   ++   ++   Q K LE D  ++K S  +  ++L  QRQL  +
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE 1708

Query: 763  ------------------LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK--- 801
                              ++L   +  K++E ++E +   +    +  + L+ + +K   
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE 1768

Query: 802  ----LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
                L+++E+E  +L+Q  +   ++ +++ + L +++      L +   E EAL  E   
Sbjct: 1769 TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQ 1828

Query: 858  VK---DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ------MENT 908
             +   +++ + +D+L+ +  +     ++    + D ++  + L+ +L V+      +E  
Sbjct: 1829 AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888

Query: 909  L-------KEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
            L       +EQ++   +L+++  E + + ++E  ++Q+  +QAQ  LK+ ++E + L+  
Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948

Query: 961  INELKQSSEQKKKQIEALQGELKIA----------VLQKTELENKLQ------QQLTQAA 1004
                +   E  + + EALQ  L  A          +L++ EL   L+      Q    A 
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008

Query: 1005 QELAAEKEKI-----SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL- 1058
            Q  + + E+        +Q+   + QE  +QLQ     R+ EL   ++  + +E+ L+  
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068

Query: 1059 AQEDLISNRNQIGNQNKL--IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
             QE++I  +  +G + +   I+ L  +   L+   A+KEQ++ E    L++ Q+  +L+ 
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE----LRETQQRNNLEA 2124

Query: 1117 KELVNEKSKLAE----IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
                ++ S + E    ++ ++ R ++E+ +L   L+  +   I+     +D    L Q K
Sbjct: 2125 LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184

Query: 1173 LE---LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS--EIKEKEV 1227
                 LQ  A  L+A+V +    QQ L+D++     EL +  +EKE +LHS       E+
Sbjct: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDEL-----ELTRRALEKE-RLHSPGATSTAEL 2238

Query: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSS----QRRVSELEKQTDDLRGEIAVLEA 1283
            G +  +  +      + A     G  K+ W+      Q+ V+ LE     L+     L +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRS 2298

Query: 1284 TVQNNQDERRALLERCLK----GEGEIEKLQTKVLELQ--RKLDNTTA-AVQELGRENQS 1336
            T++  + ERR L    ++    G  EI K        Q  R   N+ A  V EL +E   
Sbjct: 2299 TLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL 2358

Query: 1337 LQIKHTQALNRKWAED 1352
            LQ + T  L RK  +D
Sbjct: 2359 LQAQLT--LERKQKQD 2372



 Score =  218 bits (556), Expect = 2e-56
 Identities = 293/1433 (20%), Positives = 627/1433 (43%), Gaps = 158/1433 (11%)

Query: 18   SDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFK--HYEAVHDAGNDSGHGGE 75
            ++L    T ++ +   ++  +E +   + +K+L    E+ +  H E +    + S +  E
Sbjct: 279  AELQDRVTELSALLTQSQKQNEDY--EKMIKALRETVEILETNHTELMEHEASLSRNAQE 336

Query: 76   SNLALKR--DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPD-----G 128
              L+L++   D+T +  E  D   ++ +   +   L+ +   +     Q+A         
Sbjct: 337  EKLSLQQVIKDITQVMVEEGD---NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRS 393

Query: 129  LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
            ++T     +Q L QQL   Q     ++Q  D +E++   L   +     K   ER     
Sbjct: 394  VLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL----QKLTGERDTLAG 449

Query: 189  AEQKVTRLTEELNKEATVIQDLKTELLQRPGI--EDVAVLKKELVQVQTLMDNMTLERE- 245
                +    + L+KE  ++Q  + EL Q+  +  ++   L++  V++Q   D+   ++E 
Sbjct: 450  QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEE 509

Query: 246  ---------RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE------- 289
                     RE E+L++    L+++ + S + +  LR  L     E  +  QE       
Sbjct: 510  QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569

Query: 290  LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
            L + + S+ EL+    TL   +        KL   +   ++ K  +   L Q + + Q +
Sbjct: 570  LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629

Query: 350  QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
             SR+ A+E + + + V+L+E  +  + L E+ + +E + Q  +    +LQ    + ++  
Sbjct: 630  CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689

Query: 410  LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE---QQVADLQLKLSRLE 466
             ++Q ++++   +      QL + H   K Q ++ +  + +KE   ++ A L+++L  +E
Sbjct: 690  EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749

Query: 467  ---EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
               + L E++   +  +  L+ +  + Q+Q ++ + T  +L E Q       +++   + 
Sbjct: 750  RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL-EVQIQTVTQAKEVIQGEV 808

Query: 524  KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
            +   LE   ++S+      E+ER+    ++   E E     + Q+  H  +++V QL EK
Sbjct: 809  RCLKLELDTERSQ-----AEQERDAAARQLAQAEQEGKTALEQQKAAH--EKEVNQLREK 861

Query: 584  LKNQSESHKQ----AQENLHDQVQEQKAHLRAAQDRVLSLETSVNE---------LNSQL 630
             + +   H+Q    A E+L  +  E +  L+  Q  + +++    E            QL
Sbjct: 862  WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL 921

Query: 631  NESKEKVSQLDIQIKAKTELLLSAEAAK------TAQRADLQNHLDTAQNALQDKQQELN 684
               KE+VS L+  ++ + EL  +++  +        Q+   Q      Q  LQ+ Q+EL 
Sbjct: 922  ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981

Query: 685  KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
            +   Q     A LQ++     Q            + L+++ E+L+ Q+   +     V+ 
Sbjct: 982  EAARQHRDDLAALQEESSSLLQ----------DKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031

Query: 745  SKEQALQDLQQQRQLNTDLELRATELSKQL-EMEKEIVSSTRLDLQKKSEALESIKQKLT 803
              ++ L++ Q+  ++  +LE     L+  L E E+ ++     D  ++ E L +++Q + 
Sbjct: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE-LSALRQDMQ 1090

Query: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
            + + E++ L    E L QE K +  +   +    + EL+   + ++ L   L   + K +
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150

Query: 864  KVSDSLKNSKSEFE---KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK--- 917
            ++   L++++S+ E    E Q G  A    +     L   LQ  + +  + + EL     
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQA--QAQAQLASLYSALQQALGSVCESRPELSGGGD 1208

Query: 918  ------SLEKEKEASHQL----KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
                   LE ++  +  L     L      E +  A + L Q+  + QQ +  + +  Q 
Sbjct: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK 1268

Query: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
             E++    EA + ++       TEL++ LQ+QL+Q  +E +  + K + L++   +  ET
Sbjct: 1269 LEERLTDTEAEKSQV------HTELQD-LQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321

Query: 1028 FKQLQSDFYGRE---SELLATRQDLKSVEEKLSLAQEDL----ISNRNQIGNQNKLIQEL 1080
               LQS     E    E    R+ L++ +E L+   E L    +  R Q      L ++L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
            +TA++ L+  + + E + +ER +ALQ+  + K  + K L   +  LA + +    +E+E+
Sbjct: 1382 RTARSALKLKNEEVESE-RERAQALQEQGELKVAQGKAL---QENLALLTQTLAEREEEV 1437

Query: 1141 TKL---------NEELKSHKLE----SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
              L           E++   LE     +K+     D +Q  IQ+  + +   + L  AV+
Sbjct: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497

Query: 1188 QEKRNQQILKDQVKKEEE----------------ELKKEFIEKEAKLHSEIKEKEVGMK- 1230
            + ++   + ++Q+++ E+                E K + IE +     ++K++ V ++ 
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557

Query: 1231 ---KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
               + EEN  K+  Q   + E  G  + +  +      +LE+++ +L+ + + +     +
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
            +    R L ER    + E++  + ++ ELQR+ ++ T   Q+L R +Q L ++
Sbjct: 1618 STVLARELQER----DQEVKSQREQIEELQRQKEHLT---QDLERRDQELMLQ 1663



 Score =  179 bits (455), Expect = 1e-44
 Identities = 299/1380 (21%), Positives = 578/1380 (41%), Gaps = 200/1380 (14%)

Query: 92   VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151
            V+ LQA + + + + +EL+K LE   G   Q  +        + E  +L++ L   + E 
Sbjct: 56   VRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWE--------NVEEPNLDELLVRLEEEQ 107

Query: 152  FNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV---TRLTEELNKEATVIQ 208
               + + ++  Q   +L  E AD+ +K     +LRE  E+     +R  +EL ++ +  Q
Sbjct: 108  QRCESLAEVNTQ--LRLHMEKADVVNK-----ALREDVEKLTVDWSRARDELMRKESQWQ 160

Query: 209  DLKTELLQ---RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
             ++ E  +   +     +  L +E+V  +     M    +R+  +LK E  +L     S 
Sbjct: 161  -MEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRL-----SG 214

Query: 266  EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
                  LR         + V  Q  +   S   +  +  Q L   LL K Q+  K   + 
Sbjct: 215  SLLTCCLR---------LTVGAQSREPNGSGRMDGREPAQLLL--LLAKTQELEKEAHER 263

Query: 326  NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
            ++E +  K+      Q DL+  +LQ R++     L +   +  +  +  + L+E +  +E
Sbjct: 264  SQELIQLKS------QGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317

Query: 386  TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
            T +  L      L +  +E++   L LQ  I  +   ++E    + +  G  +   +L S
Sbjct: 318  TNHTELMEHEASLSRNAQEEK---LSLQQVIKDITQVMVEEGDNIAQGSGH-ENSLELDS 373

Query: 446  EKLMDKEQQVADLQLK-----LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
                  + Q AD  L      L+R  + +++        Q  ++  +QQH + +   ++ 
Sbjct: 374  SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433

Query: 501  TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
              +L++   + + +  Q  D   ++ +L      SKE   LL+K RE+L  +++  E E 
Sbjct: 434  RQRLQKLTGERDTLAGQTVDLQGEVDSL------SKER-ELLQKAREELRQQLEVLEQEA 486

Query: 561  AVLNQLQEKNHTLQEQVTQLT-EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS- 618
                +L+  N  LQ Q      +K + Q E H   +E   +++QE    L A Q   LS 
Sbjct: 487  W---RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--RERLQEMLMGLEAKQSESLSE 541

Query: 619  -------LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN---H 668
                   LE+S  E      E  E  + L    ++  EL  S    KT + ADL+     
Sbjct: 542  LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT-EVADLRAAAVK 600

Query: 669  LDTAQNALQDKQQELNKITTQLDQ----VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
            L     AL   +  LN+   QL++    V ++++  ++  + L+  L E +++  +L +K
Sbjct: 601  LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660

Query: 725  TEELEGQIKK-------LEADSLEVKASKEQALQDL----QQQRQLNTDLELRATELSKQ 773
               LE Q++K       L+AD  +++  KE+  + L     QQ    T LE    E  +Q
Sbjct: 661  NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720

Query: 774  LEM------EKEIVSSTRLDLQKKSEALESIKQKLTKQ----EEEKQILKQD-FETLSQE 822
             E+      EKE +   +  L+ + +A+E  +Q L +Q       K++L+   FE   Q 
Sbjct: 721  EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780

Query: 823  TKIQ--HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
            + I+    +L  +IQT     + ++ E   L  EL T + +  +  D+     ++ E   
Sbjct: 781  SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE--- 837

Query: 881  QKGKAAILDLEKTCKELKHQLQVQMENTLK-EQKELKKSLEKEKEASHQLKLELNSMQ-- 937
            Q+GK A+   +   ++  +QL+ + E      Q+EL K+LE  +    +L++ L   Q  
Sbjct: 838  QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897

Query: 938  ---------EQLIQAQNTLKQ----NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
                     E+  QA++ L Q     EKE   L   + + ++      +Q+E L+ ++K+
Sbjct: 898  MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957

Query: 985  AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
              L++ E    LQ QL +A +EL   KE     +++    QE    L  D    + ++  
Sbjct: 958  QKLKEQETTGILQTQLQEAQREL---KEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014

Query: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL------ 1098
             +  L + ++   L ++++     +    N++ +EL+  KA+L     +KEQ+L      
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074

Query: 1099 ----QERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKLE 1153
                Q+   AL+   +E   ++KEL  +   L  E++E +     +  +L EEL++  + 
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134

Query: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKA-AVEQEKRNQQILKDQVKK---------- 1202
              +   +L   +    Q +L L+     L+A A EQ+  NQ   + Q+            
Sbjct: 1135 EQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194

Query: 1203 ----------------------EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
                                  E ++     + K   L + +  + V    H     KL 
Sbjct: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-----KLH 1249

Query: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
              +    +    ++ + Q  + R+++ E +   +  E+  L+  +  NQ+E+        
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS------- 1302

Query: 1301 KGEGEIEKLQTKVLELQRKLDNTTAAVQ----------------ELGRENQSLQIKHTQA 1344
            K EG+   L+++++EL   + +  + ++                +  +EN + Q++H QA
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQA 1362



 Score =  164 bits (414), Expect = 7e-40
 Identities = 226/1054 (21%), Positives = 460/1054 (43%), Gaps = 131/1054 (12%)

Query: 93   QDLQASLKEEKWYSEELKKELEKYQGLQQQE----AKPDGLVTDSSAELQSLEQQLEEAQ 148
            +DL+ +    K  +EE++ E E+ Q LQ+Q     A+   L  + +   Q+L ++ EE +
Sbjct: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE 1438

Query: 149  TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208
            T    I++++   E + A L     D+K K ++E  L++   Q++ +    L      +Q
Sbjct: 1439 TLRGQIQELEKQREMQKAALELLSLDLK-KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497

Query: 209  DLKTEL-LQRPGIEDVA--------VLKKELV--------------QVQTLMDNMT---- 241
            + + +L +QR  I ++         VL+ +L+              QVQ L   +     
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557

Query: 242  LERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
            L  E E    K EC     K+L+ Q  +    ++ L  +L +  QE+     ++  L+S 
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 297  ----VNELTQKNQTLT------ENLLKKEQDYTK-LEEKHNEESVSKKNIQATLHQKDLD 345
                  EL +++Q +       E L ++++  T+ LE +  E  + K+ IQ    Q+   
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677

Query: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE----LSEVETKYQHLKAEFKQLQQQ 401
             + L+  L   + SL     EL+ + +  Q+  EE            +H+K   +  +++
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737

Query: 402  REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ---LSSEKLMDKEQQVADL 458
             E +++H  +LQ   +QL  +L    R++GE    L ++ Q   +  ++L +  +Q    
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG--- 1794

Query: 459  QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
            +LK   L+ QL E      +   +L+  +Q+ Q+ Q  ++    K    Q  LEQ    +
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854

Query: 519  GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVT 578
             ++  ++Q+        KE    LE+E      ++QA E    VL  L+ ++   ++ + 
Sbjct: 1855 KERHGELQD-------HKEQARRLEEELAVEGRRVQALE---EVLGDLRAESREQEKALL 1904

Query: 579  QLTEKLKNQSESHK-----------QAQENLHDQVQEQKA----------HLRAAQDRVL 617
             L ++   Q++ H+           QAQ  L ++ QE +A             AA+ R  
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964

Query: 618  SLETSVNELNSQLNESKEKV---SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
            +L+ ++ + ++ L   ++ +   ++L   ++A T  L ++  A  A    L+  L   + 
Sbjct: 1965 ALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024

Query: 675  ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE-----------YKEKYLSLEQ 723
             +QD+     +   QL Q  A+  ++  H  + E  L++            +++ L  E+
Sbjct: 2025 EIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084

Query: 724  KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
            + EE+ G  + +    L + A KEQ + +L++ +Q N    L  +  +  +E +   + S
Sbjct: 2085 EEEEIRGLHQSVRELQLTL-AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143

Query: 784  TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
                LQ++ E L++  ++   +E E +   QD      +TK            +V+ LQ+
Sbjct: 2144 LEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK-----------ASVSSLQE 2192

Query: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK-----ELK 898
            V M  +A + E  + + +L    D L+ ++   EKE      A    E   +     +L 
Sbjct: 2193 VAMFLQASVLERDSEQQRL---QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG 2249

Query: 899  HQLQVQMENTL--KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
                V+ E +    E++  ++ LE  ++A  +L+++ + +Q   +Q ++TL+Q E+E ++
Sbjct: 2250 EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRK 2309

Query: 957  LQGNINELKQSSEQKKKQIEALQGELKIAVLQK---TELENKLQQQLTQAAQELAAEKEK 1013
            L+       Q+   +  +  A     +    QK    +   +LQ+++     +L  E+++
Sbjct: 2310 LKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQ 2369

Query: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
                Q+   +S +T ++L    +     LLA  Q
Sbjct: 2370 ---KQDYITRSAQTSRELAGLHHSLSHSLLAVAQ 2400



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 155/800 (19%), Positives = 335/800 (41%), Gaps = 108/800 (13%)

Query: 573  LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
            L+EQV  L +++     +  +  +N  +  Q Q   +R  Q +VL   +   EL  +L  
Sbjct: 20   LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79

Query: 633  SKEKVSQL--DIQIKAKTELLLSAEAAKTAQRAD--------LQNHLDTAQNALQDKQQE 682
            +   + Q   +++     ELL+  E  +  QR +        L+ H++ A    +  +++
Sbjct: 80   TGGPIPQRWENVEEPNLDELLVRLEEEQ--QRCESLAEVNTQLRLHMEKADVVNKALRED 137

Query: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ-KTEELEGQIKKLEADSLE 741
            + K+T    +   +L  K+    Q+E   +E+ + YL  E  +   L  ++       LE
Sbjct: 138  VEKLTVDWSRARDELMRKESQW-QME---QEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193

Query: 742  VKASKEQALQDLQQQR-QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
            +K++ ++ L +L+ +  +L+  L      L+   +  +E   S R+D ++ ++ L  +  
Sbjct: 194  MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGREPAQLL-LLLA 251

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
            K  + E+E     Q+   L  +  ++  EL +R    VTEL        AL+T+      
Sbjct: 252  KTQELEKEAHERSQELIQLKSQGDLEKAELQDR----VTELS-------ALLTQS----- 295

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN---TLKEQKELKK 917
                            +K+N+       D EK  K L+  +++   N    ++ +  L +
Sbjct: 296  ----------------QKQNE-------DYEKMIKALRETVEILETNHTELMEHEASLSR 332

Query: 918  SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
            + ++EK +  Q+   +  + + +++  + + Q    E  L+ + +   Q   Q       
Sbjct: 333  NAQEEKLSLQQV---IKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDAD---- 385

Query: 978  LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY- 1036
                 K   L ++ L  + +Q +    Q+LA  +E +++LQ  +++ +E  K L+     
Sbjct: 386  -----KALTLVRSVLTRR-RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQK 439

Query: 1037 --GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE----LKTAKATLEQD 1090
              G    L     DL+   + LS  +E L   R ++  Q +++++    L+     L+  
Sbjct: 440  LTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499

Query: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH 1150
                + Q +E+ + L    +E+   ++ L+  ++K +E          E+  L E L+S 
Sbjct: 500  GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-------SLSELITLREALESS 552

Query: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
             LE            +LL Q++ E+       + ++ +   ++  LK +V        K 
Sbjct: 553  HLEG-----------ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL 601

Query: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
                EA    ++   +  ++  EEN++  +    A        ++   + Q  ++E EK+
Sbjct: 602  SALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA--------EQARNALQVDLAEAEKR 653

Query: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
             + L  +   LEA +Q  ++    L       + E E++Q K+ E + + +  T  +++L
Sbjct: 654  REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713

Query: 1331 GRENQSLQIKHTQALNRKWA 1350
             +E +  +    +A+  K A
Sbjct: 714  HQEAKRQEEVLARAVQEKEA 733



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 60/312 (19%), Positives = 124/312 (39%), Gaps = 29/312 (9%)

Query: 12   RVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSG 71
            R   Q ++L++      T  +  +S     + P+  + L       +  EA      +  
Sbjct: 2114 RETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKA 2173

Query: 72   HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLV 130
                 +LA  +  V+ L++    LQAS+ E     + L+ ELE   + L+++     G  
Sbjct: 2174 QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGAT 2233

Query: 131  TDSS-----------AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY 179
            + +             E+  +E +      E  + +Q  +  +Q  A+L  + + ++   
Sbjct: 2234 STAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHN 2293

Query: 180  DEERSLREAAEQKVTRLTEELNKEATV-IQDLKTELLQRPGIED-----------VAVLK 227
             + RS  E  E++  +L  E  + A     ++       P  +D           VA L+
Sbjct: 2294 VQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQ 2353

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            KE+V +Q     +TLER+++ + +     +   + A    ++S     +A+ P E  V  
Sbjct: 2354 KEVVLLQA---QLTLERKQKQDYI-TRSAQTSRELAGLHHSLSHSLLAVAQAP-EATVLE 2408

Query: 288  QELQKLKSSVNE 299
             E ++L  S+ +
Sbjct: 2409 AETRRLDESLTQ 2420


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  246 bits (628), Expect = 1e-64
 Identities = 283/1253 (22%), Positives = 565/1253 (45%), Gaps = 151/1253 (12%)

Query: 71   GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY----SEELKKELEKYQGLQQQEAKP 126
            G+      A ++  +T ++   ++  A LK   W       ++K  L+  +  ++ +AK 
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 127  DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
            D        ELQ  +++ ++A+ E      +K+L EQK +QL  E   ++ +   E  L 
Sbjct: 859  D--------ELQKTKERQQKAENE------LKEL-EQKHSQLTEEKNLLQEQLQAETELY 903

Query: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
              AE+   RL  +  +   ++ +++  L      E+     ++L   +  M    L+ E 
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            + E+ +   +KLQ +  ++EA I +L         E+ V   +  KL      L ++   
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLE-------DEILVMDDQNNKLSKERKLLEERISD 1010

Query: 307  LTENLLKKEQ---DYTKLEEKHNEESVSKKNIQATLHQKD-LDCQQLQSRLSASETSLHR 362
            LT NL ++E+   + TKL+ KH E  +S+  ++    +K   + ++L+ +L    +  H 
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH- 1068

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                            E++++++ +   LK    QL ++ EE +    +L  EI Q ++ 
Sbjct: 1069 ----------------EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 423  LLETERQLGEAHGRLKE-QRQLSSEKLM--DKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
            L    +++ E  G + + Q  L SE+      E+Q  DL  +L  L+ +L E   +ST  
Sbjct: 1110 L----KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTAT 1164

Query: 480  QHQLDKTKQQHQE--QQALQQST---TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
            Q +L   ++Q     ++AL + T    A+++E +    Q + ++ ++ ++ +  +A L K
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQVTQLTEKLKNQSES 590
            +K+    LEKE  DL        GE  VL Q    ++ K   L+ QV +L  K  +   +
Sbjct: 1225 NKQT---LEKENADL-------AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 591  HKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
              +  + +H   ++V+     L  A+ + + L   V  L+SQL +++E      +Q + +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQEETR 1329

Query: 648  TELLLSAEAAK-TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
             +L +S +  +   +R  LQ+ LD    A Q+ ++ ++ +  QL     KLQD       
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389

Query: 707  LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
            LE   K ++++  +L Q+ EE      KLE     ++   +  + DL  QRQL ++LE +
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 767  ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ----KLTKQEEEKQILKQDFETLSQE 822
              +  + L  EK I SS   D + ++EA    K+     L +  EE    K++ E  ++ 
Sbjct: 1450 QRKFDQLLAEEKNI-SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508

Query: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
             K + E+L +        + +++  K AL T++  +K +L ++ D L           Q 
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QA 1557

Query: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
             + A L LE   + LK Q +  ++   ++ +E ++ L+++    H+ + EL   ++Q   
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ---LHEYETELEDERKQRAL 1614

Query: 943  AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
            A    K+ E + + L+   +   +  E+  KQ+  LQ ++K             Q++L  
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----------DFQRELED 1663

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQE 1061
            A    A+  E  +  + N +K+    K L++D    + +L A  +  K  + EK  LA+E
Sbjct: 1664 AR---ASRDEIFATAKENEKKA----KSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 1062 --DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
                +S RN + ++ +    L+   A LE++  +++  ++     ++   ++      EL
Sbjct: 1717 LASSLSGRNALQDEKR---RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
              E+S   + E  + + E++    N+EL+S KL  ++     K    +       L+ K 
Sbjct: 1774 ATERSTAQKNESARQQLERQ----NKELRS-KLHEMEGAVKSKFKSTI-----AALEAKI 1823

Query: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEIKEKEVGMKKHEENEA 1237
              L+  VEQE R +Q     +K+++++LK+    +E E K+  + KE+    +K      
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ---AEKGNARVK 1880

Query: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
            +L  Q+    E    +    +  QR + E  +  + +  E+  L++ ++   +
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score =  222 bits (565), Expect = 2e-57
 Identities = 254/1140 (22%), Positives = 501/1140 (43%), Gaps = 118/1140 (10%)

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q    E  +     EL K  +       EL++L+   ++LT++   L E L  + + Y +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDC-------QQLQSRLSASETSLHRIHVELSEKGEA 373
             EE     +  K+ ++  LH+ +          QQLQ+        +  +  +L E+  A
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
             QKL+ E    E K + L+ E   +  Q  +  +    L+  I+ L + L E        
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-------- 1017

Query: 434  HGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
                +E++  +  KL +K E  +++L+++L + E+  +E      +L+       +Q  +
Sbjct: 1018 ----EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
             QA       +L + + +L+  L ++ D+  +  N    +++ + +IS L+   EDL   
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ---EDL--- 1127

Query: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
                + E A  N+ +++   L E++  L  +L++  +S    QE    + QE     +A 
Sbjct: 1128 ----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 613  QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
             +   S E  V E+  +  ++ E++++   Q K     L   +     + ADL   L   
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 673  QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
              A Q+ + +  K+  Q+ ++ +K  D +   ++L   + + + +  S+     E EG+ 
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 733  KKLEAD--SLEVKASKEQALQDLQQQRQLNTDLELRATE-----LSKQLEMEKEI----- 780
             KL  D  SL  +    Q L   + +++LN   +LR  E     L  QL+ E E      
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363

Query: 781  --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------EELNN 832
              +S+  + L    + L+     +   EE K+  +++ E L+Q+ + +       E+  N
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
            R+Q  + +L      +  L++ L   + K  ++    KN  S++  E  + +A     E 
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EA 1478

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
              KE K    + +   L+E  E K+ LE+    +  LK E+    E L+ +++ + +N  
Sbjct: 1479 REKETK---ALSLARALEEALEAKEELER---TNKMLKAEM----EDLVSSKDDVGKNVH 1528

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
            E   L+ +   L+   E+ K Q+E L+ EL+     K  LE  +Q    Q  ++L A   
Sbjct: 1529 E---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD- 1584

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESEL----------LATRQDLKSVEEKLSLAQED 1062
                     E+++E  +QLQ   +  E+EL           A ++ L+   + L L  + 
Sbjct: 1585 ---------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 1063 LISNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
             I  R + I    KL  ++K  +  LE   A +++       A ++ +K KSL E +L+ 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKAKSL-EADLMQ 1691

Query: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL------IQQKLE- 1174
             +  LA  E  + + + E  +L EEL S    S+     L+D K+ L      ++++LE 
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIAQLEEELEE 1747

Query: 1175 ----LQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEAK-LHSEIKEKEVG 1228
                ++  +D ++ A +Q E+ + ++  ++   ++ E  ++ +E++ K L S++ E E  
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 1229 MK-KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK-------QTDDLRGEIAV 1280
            +K K +   A L  +I  L E +    +E Q++ + + + +K       Q +D R     
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
             +   +      + L  +  + E E +++     +LQR+LD  T + + +GRE  +L+ K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score =  168 bits (425), Expect = 4e-41
 Identities = 181/920 (19%), Positives = 414/920 (45%), Gaps = 70/920 (7%)

Query: 477  TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
            T+++  L  T+Q+  E+   ++    K +E Q   E  L+++  K  ++   + LLQ+  
Sbjct: 839  TKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 537  ENISLLEKEREDLYAKIQAGEGET--------AVLNQLQEKNHTLQEQVTQLTEK---LK 585
            +  + L  E E++  ++ A + E         A L + +++   LQ +  ++ ++   L+
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
             Q E  + A++ L  +    +A ++  +D +L ++   N+L+ +    +E++S L     
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-- 1014

Query: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQ 701
                  L+ E  K      L+N  ++  + L+ + ++  K   +L+++  KL+    D  
Sbjct: 1015 ------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E  + L++ + E K   + L +K EEL+  + +L+ +     A K  AL+ +++      
Sbjct: 1069 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEI----AQKNNALKKIRE------ 1115

Query: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
             LE   ++L + L+ E+   +      +   E LE++K +L    +     ++      Q
Sbjct: 1116 -LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E  +  + L+   ++   ++Q+++ +    + EL+   ++  +   +L  +K   EKEN 
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234

Query: 882  KGKAAILDLEKTCKELKHQ---LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
                 +  L +  +E++H+   L+ Q++    +  + +++  +  +  H+L+ E+ S+  
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294

Query: 939  QLIQAQNTLKQNEKE----EQQLQGNINELKQSSEQKK------KQIEALQGELKIAVLQ 988
             L +A+    +  K+      QLQ     L++ + QK       +Q+E  +  L+  + +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG---RESELLAT 1045
            + E +  L++ ++    +L+  K+K+    +  E  +E  K+ Q +      +  E  A 
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE----QQLQER 1101
               L+  + +L    +DL+ +   + NQ +L+  L+  +   +Q  A+++    +   ER
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
             +A  +  +EK  K   L     +  E +E   R  K +    E+L S K +  K +  L
Sbjct: 1472 DRAEAEA-REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530

Query: 1162 KDAKQLLIQQ----KLELQGKADSLKAAVEQEKR---NQQILKDQVKKEEEELKKEFIEK 1214
            + +K+ L  Q    K +L+   D L+A  + + R   N Q LK Q +++ +   ++  EK
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
              +L  ++ E E  ++   +  A        L  +L  ++ +  S+ +   E  KQ   L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGREN 1334
            + ++   +  +++ +  R  +     + E + + L+  +++LQ  L     A ++   E 
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 1335 QSLQIKHTQALNRKWAEDNE 1354
            + L  +   +L+ + A  +E
Sbjct: 1711 EELAEELASSLSGRNALQDE 1730


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  246 bits (628), Expect = 1e-64
 Identities = 283/1253 (22%), Positives = 565/1253 (45%), Gaps = 151/1253 (12%)

Query: 71   GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY----SEELKKELEKYQGLQQQEAKP 126
            G+      A ++  +T ++   ++  A LK   W       ++K  L+  +  ++ +AK 
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 127  DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
            D        ELQ  +++ ++A+ E      +K+L EQK +QL  E   ++ +   E  L 
Sbjct: 866  D--------ELQKTKERQQKAENE------LKEL-EQKHSQLTEEKNLLQEQLQAETELY 910

Query: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
              AE+   RL  +  +   ++ +++  L      E+     ++L   +  M    L+ E 
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            + E+ +   +KLQ +  ++EA I +L         E+ V   +  KL      L ++   
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLE-------DEILVMDDQNNKLSKERKLLEERISD 1017

Query: 307  LTENLLKKEQ---DYTKLEEKHNEESVSKKNIQATLHQKD-LDCQQLQSRLSASETSLHR 362
            LT NL ++E+   + TKL+ KH E  +S+  ++    +K   + ++L+ +L    +  H 
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH- 1075

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                            E++++++ +   LK    QL ++ EE +    +L  EI Q ++ 
Sbjct: 1076 ----------------EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 423  LLETERQLGEAHGRLKE-QRQLSSEKLM--DKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
            L    +++ E  G + + Q  L SE+      E+Q  DL  +L  L+ +L E   +ST  
Sbjct: 1117 L----KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTAT 1171

Query: 480  QHQLDKTKQQHQE--QQALQQST---TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
            Q +L   ++Q     ++AL + T    A+++E +    Q + ++ ++ ++ +  +A L K
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQVTQLTEKLKNQSES 590
            +K+    LEKE  DL        GE  VL Q    ++ K   L+ QV +L  K  +   +
Sbjct: 1232 NKQT---LEKENADL-------AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 591  HKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
              +  + +H   ++V+     L  A+ + + L   V  L+SQL +++E      +Q + +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQEETR 1336

Query: 648  TELLLSAEAAK-TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
             +L +S +  +   +R  LQ+ LD    A Q+ ++ ++ +  QL     KLQD       
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396

Query: 707  LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
            LE   K ++++  +L Q+ EE      KLE     ++   +  + DL  QRQL ++LE +
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 767  ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ----KLTKQEEEKQILKQDFETLSQE 822
              +  + L  EK I SS   D + ++EA    K+     L +  EE    K++ E  ++ 
Sbjct: 1457 QRKFDQLLAEEKNI-SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515

Query: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
             K + E+L +        + +++  K AL T++  +K +L ++ D L           Q 
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QA 1564

Query: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
             + A L LE   + LK Q +  ++   ++ +E ++ L+++    H+ + EL   ++Q   
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ---LHEYETELEDERKQRAL 1621

Query: 943  AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
            A    K+ E + + L+   +   +  E+  KQ+  LQ ++K             Q++L  
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----------DFQRELED 1670

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQE 1061
            A    A+  E  +  + N +K+    K L++D    + +L A  +  K  + EK  LA+E
Sbjct: 1671 AR---ASRDEIFATAKENEKKA----KSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 1062 --DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
                +S RN + ++ +    L+   A LE++  +++  ++     ++   ++      EL
Sbjct: 1724 LASSLSGRNALQDEKR---RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
              E+S   + E  + + E++    N+EL+S KL  ++     K    +       L+ K 
Sbjct: 1781 ATERSTAQKNESARQQLERQ----NKELRS-KLHEMEGAVKSKFKSTI-----AALEAKI 1830

Query: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEIKEKEVGMKKHEENEA 1237
              L+  VEQE R +Q     +K+++++LK+    +E E K+  + KE+    +K      
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ---AEKGNARVK 1887

Query: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
            +L  Q+    E    +    +  QR + E  +  + +  E+  L++ ++   +
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score =  222 bits (565), Expect = 2e-57
 Identities = 254/1140 (22%), Positives = 501/1140 (43%), Gaps = 118/1140 (10%)

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q    E  +     EL K  +       EL++L+   ++LT++   L E L  + + Y +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDC-------QQLQSRLSASETSLHRIHVELSEKGEA 373
             EE     +  K+ ++  LH+ +          QQLQ+        +  +  +L E+  A
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
             QKL+ E    E K + L+ E   +  Q  +  +    L+  I+ L + L E        
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-------- 1024

Query: 434  HGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
                +E++  +  KL +K E  +++L+++L + E+  +E      +L+       +Q  +
Sbjct: 1025 ----EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
             QA       +L + + +L+  L ++ D+  +  N    +++ + +IS L+   EDL   
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ---EDL--- 1134

Query: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
                + E A  N+ +++   L E++  L  +L++  +S    QE    + QE     +A 
Sbjct: 1135 ----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 613  QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
             +   S E  V E+  +  ++ E++++   Q K     L   +     + ADL   L   
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 673  QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
              A Q+ + +  K+  Q+ ++ +K  D +   ++L   + + + +  S+     E EG+ 
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 733  KKLEAD--SLEVKASKEQALQDLQQQRQLNTDLELRATE-----LSKQLEMEKEI----- 780
             KL  D  SL  +    Q L   + +++LN   +LR  E     L  QL+ E E      
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370

Query: 781  --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------EELNN 832
              +S+  + L    + L+     +   EE K+  +++ E L+Q+ + +       E+  N
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
            R+Q  + +L      +  L++ L   + K  ++    KN  S++  E  + +A     E 
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EA 1485

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
              KE K    + +   L+E  E K+ LE+    +  LK E+    E L+ +++ + +N  
Sbjct: 1486 REKETK---ALSLARALEEALEAKEELER---TNKMLKAEM----EDLVSSKDDVGKNVH 1535

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
            E   L+ +   L+   E+ K Q+E L+ EL+     K  LE  +Q    Q  ++L A   
Sbjct: 1536 E---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD- 1591

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESEL----------LATRQDLKSVEEKLSLAQED 1062
                     E+++E  +QLQ   +  E+EL           A ++ L+   + L L  + 
Sbjct: 1592 ---------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 1063 LISNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
             I  R + I    KL  ++K  +  LE   A +++       A ++ +K KSL E +L+ 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKAKSL-EADLMQ 1698

Query: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL------IQQKLE- 1174
             +  LA  E  + + + E  +L EEL S    S+     L+D K+ L      ++++LE 
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIAQLEEELEE 1754

Query: 1175 ----LQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEAK-LHSEIKEKEVG 1228
                ++  +D ++ A +Q E+ + ++  ++   ++ E  ++ +E++ K L S++ E E  
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 1229 MK-KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK-------QTDDLRGEIAV 1280
            +K K +   A L  +I  L E +    +E Q++ + + + +K       Q +D R     
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
             +   +      + L  +  + E E +++     +LQR+LD  T + + +GRE  +L+ K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score =  168 bits (425), Expect = 4e-41
 Identities = 181/920 (19%), Positives = 414/920 (45%), Gaps = 70/920 (7%)

Query: 477  TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
            T+++  L  T+Q+  E+   ++    K +E Q   E  L+++  K  ++   + LLQ+  
Sbjct: 846  TKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 537  ENISLLEKEREDLYAKIQAGEGET--------AVLNQLQEKNHTLQEQVTQLTEK---LK 585
            +  + L  E E++  ++ A + E         A L + +++   LQ +  ++ ++   L+
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
             Q E  + A++ L  +    +A ++  +D +L ++   N+L+ +    +E++S L     
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-- 1021

Query: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQ 701
                  L+ E  K      L+N  ++  + L+ + ++  K   +L+++  KL+    D  
Sbjct: 1022 ------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E  + L++ + E K   + L +K EEL+  + +L+ +     A K  AL+ +++      
Sbjct: 1076 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEI----AQKNNALKKIRE------ 1122

Query: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
             LE   ++L + L+ E+   +      +   E LE++K +L    +     ++      Q
Sbjct: 1123 -LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E  +  + L+   ++   ++Q+++ +    + EL+   ++  +   +L  +K   EKEN 
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241

Query: 882  KGKAAILDLEKTCKELKHQ---LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
                 +  L +  +E++H+   L+ Q++    +  + +++  +  +  H+L+ E+ S+  
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 939  QLIQAQNTLKQNEKE----EQQLQGNINELKQSSEQKK------KQIEALQGELKIAVLQ 988
             L +A+    +  K+      QLQ     L++ + QK       +Q+E  +  L+  + +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG---RESELLAT 1045
            + E +  L++ ++    +L+  K+K+    +  E  +E  K+ Q +      +  E  A 
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE----QQLQER 1101
               L+  + +L    +DL+ +   + NQ +L+  L+  +   +Q  A+++    +   ER
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
             +A  +  +EK  K   L     +  E +E   R  K +    E+L S K +  K +  L
Sbjct: 1479 DRAEAEA-REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537

Query: 1162 KDAKQLLIQQ----KLELQGKADSLKAAVEQEKR---NQQILKDQVKKEEEELKKEFIEK 1214
            + +K+ L  Q    K +L+   D L+A  + + R   N Q LK Q +++ +   ++  EK
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
              +L  ++ E E  ++   +  A        L  +L  ++ +  S+ +   E  KQ   L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGREN 1334
            + ++   +  +++ +  R  +     + E + + L+  +++LQ  L     A ++   E 
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 1335 QSLQIKHTQALNRKWAEDNE 1354
            + L  +   +L+ + A  +E
Sbjct: 1718 EELAEELASSLSGRNALQDE 1737


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  245 bits (626), Expect = 2e-64
 Identities = 283/1249 (22%), Positives = 564/1249 (45%), Gaps = 151/1249 (12%)

Query: 71   GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY----SEELKKELEKYQGLQQQEAKP 126
            G+      A ++  +T ++   ++  A LK   W       ++K  L+  +  ++ +AK 
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 127  DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
            D        ELQ  +++ ++A+ E      +K+L EQK +QL  E   ++ +   E  L 
Sbjct: 866  D--------ELQKTKERQQKAENE------LKEL-EQKHSQLTEEKNLLQEQLQAETELY 910

Query: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
              AE+   RL  +  +   ++ +++  L      E+     ++L   +  M    L+ E 
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            + E+ +   +KLQ +  ++EA I +L         E+ V   +  KL      L ++   
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLE-------DEILVMDDQNNKLSKERKLLEERISD 1017

Query: 307  LTENLLKKEQ---DYTKLEEKHNEESVSKKNIQATLHQKD-LDCQQLQSRLSASETSLHR 362
            LT NL ++E+   + TKL+ KH E  +S+  ++    +K   + ++L+ +L    +  H 
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH- 1075

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                            E++++++ +   LK    QL ++ EE +    +L  EI Q ++ 
Sbjct: 1076 ----------------EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 423  LLETERQLGEAHGRLKE-QRQLSSEKLM--DKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
            L    +++ E  G + + Q  L SE+      E+Q  DL  +L  L+ +L E   +ST  
Sbjct: 1117 L----KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTAT 1171

Query: 480  QHQLDKTKQQHQE--QQALQQST---TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
            Q +L   ++Q     ++AL + T    A+++E +    Q + ++ ++ ++ +  +A L K
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQVTQLTEKLKNQSES 590
            +K+    LEKE  DL        GE  VL Q    ++ K   L+ QV +L  K  +   +
Sbjct: 1232 NKQT---LEKENADL-------AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 591  HKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
              +  + +H   ++V+     L  A+ + + L   V  L+SQL +++E      +Q + +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQEETR 1336

Query: 648  TELLLSAEAAK-TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
             +L +S +  +   +R  LQ+ LD    A Q+ ++ ++ +  QL     KLQD       
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396

Query: 707  LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
            LE   K ++++  +L Q+ EE      KLE     ++   +  + DL  QRQL ++LE +
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 767  ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ----KLTKQEEEKQILKQDFETLSQE 822
              +  + L  EK I SS   D + ++EA    K+     L +  EE    K++ E  ++ 
Sbjct: 1457 QRKFDQLLAEEKNI-SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515

Query: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
             K + E+L +        + +++  K AL T++  +K +L ++ D L           Q 
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QA 1564

Query: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
             + A L LE   + LK Q +  ++   ++ +E ++ L+++    H+ + EL   ++Q   
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ---LHEYETELEDERKQRAL 1621

Query: 943  AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
            A    K+ E + + L+   +   +  E+  KQ+  LQ ++K             Q++L  
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----------DFQRELED 1670

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQE 1061
            A    A+  E  +  + N +K+    K L++D    + +L A  +  K  + EK  LA+E
Sbjct: 1671 AR---ASRDEIFATAKENEKKA----KSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723

Query: 1062 --DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
                +S RN + ++ +    L+   A LE++  +++  ++     ++   ++      EL
Sbjct: 1724 LASSLSGRNALQDEKR---RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
              E+S   + E  + + E++    N+EL+S KL  ++     K    +       L+ K 
Sbjct: 1781 ATERSTAQKNESARQQLERQ----NKELRS-KLHEMEGAVKSKFKSTI-----AALEAKI 1830

Query: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEIKEKEVGMKKHEENEA 1237
              L+  VEQE R +Q     +K+++++LK+    +E E K+  + KE+    +K      
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ---AEKGNARVK 1887

Query: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
            +L  Q+    E    +    +  QR + E  +  + +  E+  L++ ++
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score =  222 bits (565), Expect = 2e-57
 Identities = 254/1140 (22%), Positives = 501/1140 (43%), Gaps = 118/1140 (10%)

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q    E  +     EL K  +       EL++L+   ++LT++   L E L  + + Y +
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDC-------QQLQSRLSASETSLHRIHVELSEKGEA 373
             EE     +  K+ ++  LH+ +          QQLQ+        +  +  +L E+  A
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
             QKL+ E    E K + L+ E   +  Q  +  +    L+  I+ L + L E        
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-------- 1024

Query: 434  HGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
                +E++  +  KL +K E  +++L+++L + E+  +E      +L+       +Q  +
Sbjct: 1025 ----EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
             QA       +L + + +L+  L ++ D+  +  N    +++ + +IS L+   EDL   
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ---EDL--- 1134

Query: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
                + E A  N+ +++   L E++  L  +L++  +S    QE    + QE     +A 
Sbjct: 1135 ----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 613  QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
             +   S E  V E+  +  ++ E++++   Q K     L   +     + ADL   L   
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250

Query: 673  QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
              A Q+ + +  K+  Q+ ++ +K  D +   ++L   + + + +  S+     E EG+ 
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 733  KKLEAD--SLEVKASKEQALQDLQQQRQLNTDLELRATE-----LSKQLEMEKEI----- 780
             KL  D  SL  +    Q L   + +++LN   +LR  E     L  QL+ E E      
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370

Query: 781  --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------EELNN 832
              +S+  + L    + L+     +   EE K+  +++ E L+Q+ + +       E+  N
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
            R+Q  + +L      +  L++ L   + K  ++    KN  S++  E  + +A     E 
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EA 1485

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
              KE K    + +   L+E  E K+ LE+    +  LK E+    E L+ +++ + +N  
Sbjct: 1486 REKETK---ALSLARALEEALEAKEELER---TNKMLKAEM----EDLVSSKDDVGKNVH 1535

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
            E   L+ +   L+   E+ K Q+E L+ EL+     K  LE  +Q    Q  ++L A   
Sbjct: 1536 E---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD- 1591

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESEL----------LATRQDLKSVEEKLSLAQED 1062
                     E+++E  +QLQ   +  E+EL           A ++ L+   + L L  + 
Sbjct: 1592 ---------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 1063 LISNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
             I  R + I    KL  ++K  +  LE   A +++       A ++ +K KSL E +L+ 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKAKSL-EADLMQ 1698

Query: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL------IQQKLE- 1174
             +  LA  E  + + + E  +L EEL S    S+     L+D K+ L      ++++LE 
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIAQLEEELEE 1754

Query: 1175 ----LQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEAK-LHSEIKEKEVG 1228
                ++  +D ++ A +Q E+ + ++  ++   ++ E  ++ +E++ K L S++ E E  
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 1229 MK-KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK-------QTDDLRGEIAV 1280
            +K K +   A L  +I  L E +    +E Q++ + + + +K       Q +D R     
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
             +   +      + L  +  + E E +++     +LQR+LD  T + + +GRE  +L+ K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score =  168 bits (425), Expect = 4e-41
 Identities = 181/920 (19%), Positives = 414/920 (45%), Gaps = 70/920 (7%)

Query: 477  TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
            T+++  L  T+Q+  E+   ++    K +E Q   E  L+++  K  ++   + LLQ+  
Sbjct: 846  TKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 537  ENISLLEKEREDLYAKIQAGEGET--------AVLNQLQEKNHTLQEQVTQLTEK---LK 585
            +  + L  E E++  ++ A + E         A L + +++   LQ +  ++ ++   L+
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
             Q E  + A++ L  +    +A ++  +D +L ++   N+L+ +    +E++S L     
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-- 1021

Query: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQ 701
                  L+ E  K      L+N  ++  + L+ + ++  K   +L+++  KL+    D  
Sbjct: 1022 ------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E  + L++ + E K   + L +K EEL+  + +L+ +     A K  AL+ +++      
Sbjct: 1076 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEI----AQKNNALKKIRE------ 1122

Query: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
             LE   ++L + L+ E+   +      +   E LE++K +L    +     ++      Q
Sbjct: 1123 -LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E  +  + L+   ++   ++Q+++ +    + EL+   ++  +   +L  +K   EKEN 
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241

Query: 882  KGKAAILDLEKTCKELKHQ---LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
                 +  L +  +E++H+   L+ Q++    +  + +++  +  +  H+L+ E+ S+  
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 939  QLIQAQNTLKQNEKE----EQQLQGNINELKQSSEQKK------KQIEALQGELKIAVLQ 988
             L +A+    +  K+      QLQ     L++ + QK       +Q+E  +  L+  + +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG---RESELLAT 1045
            + E +  L++ ++    +L+  K+K+    +  E  +E  K+ Q +      +  E  A 
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE----QQLQER 1101
               L+  + +L    +DL+ +   + NQ +L+  L+  +   +Q  A+++    +   ER
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
             +A  +  +EK  K   L     +  E +E   R  K +    E+L S K +  K +  L
Sbjct: 1479 DRAEAEA-REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537

Query: 1162 KDAKQLLIQQ----KLELQGKADSLKAAVEQEKR---NQQILKDQVKKEEEELKKEFIEK 1214
            + +K+ L  Q    K +L+   D L+A  + + R   N Q LK Q +++ +   ++  EK
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
              +L  ++ E E  ++   +  A        L  +L  ++ +  S+ +   E  KQ   L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGREN 1334
            + ++   +  +++ +  R  +     + E + + L+  +++LQ  L     A ++   E 
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 1335 QSLQIKHTQALNRKWAEDNE 1354
            + L  +   +L+ + A  +E
Sbjct: 1718 EELAEELASSLSGRNALQDE 1737


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  245 bits (626), Expect = 2e-64
 Identities = 283/1249 (22%), Positives = 564/1249 (45%), Gaps = 151/1249 (12%)

Query: 71   GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY----SEELKKELEKYQGLQQQEAKP 126
            G+      A ++  +T ++   ++  A LK   W       ++K  L+  +  ++ +AK 
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 127  DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
            D        ELQ  +++ ++A+ E      +K+L EQK +QL  E   ++ +   E  L 
Sbjct: 859  D--------ELQKTKERQQKAENE------LKEL-EQKHSQLTEEKNLLQEQLQAETELY 903

Query: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
              AE+   RL  +  +   ++ +++  L      E+     ++L   +  M    L+ E 
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARL------EEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            + E+ +   +KLQ +  ++EA I +L         E+ V   +  KL      L ++   
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLE-------DEILVMDDQNNKLSKERKLLEERISD 1010

Query: 307  LTENLLKKEQ---DYTKLEEKHNEESVSKKNIQATLHQKD-LDCQQLQSRLSASETSLHR 362
            LT NL ++E+   + TKL+ KH E  +S+  ++    +K   + ++L+ +L    +  H 
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKH-ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH- 1068

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                            E++++++ +   LK    QL ++ EE +    +L  EI Q ++ 
Sbjct: 1069 ----------------EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 423  LLETERQLGEAHGRLKE-QRQLSSEKLM--DKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
            L    +++ E  G + + Q  L SE+      E+Q  DL  +L  L+ +L E   +ST  
Sbjct: 1110 L----KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTAT 1164

Query: 480  QHQLDKTKQQHQE--QQALQQST---TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
            Q +L   ++Q     ++AL + T    A+++E +    Q + ++ ++ ++ +  +A L K
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQVTQLTEKLKNQSES 590
            +K+    LEKE  DL        GE  VL Q    ++ K   L+ QV +L  K  +   +
Sbjct: 1225 NKQT---LEKENADL-------AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 591  HKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
              +  + +H   ++V+     L  A+ + + L   V  L+SQL +++E      +Q + +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQEETR 1329

Query: 648  TELLLSAEAAK-TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
             +L +S +  +   +R  LQ+ LD    A Q+ ++ ++ +  QL     KLQD       
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389

Query: 707  LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
            LE   K ++++  +L Q+ EE      KLE     ++   +  + DL  QRQL ++LE +
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 767  ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ----KLTKQEEEKQILKQDFETLSQE 822
              +  + L  EK I SS   D + ++EA    K+     L +  EE    K++ E  ++ 
Sbjct: 1450 QRKFDQLLAEEKNI-SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508

Query: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
             K + E+L +        + +++  K AL T++  +K +L ++ D L           Q 
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL-----------QA 1557

Query: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
             + A L LE   + LK Q +  ++   ++ +E ++ L+++    H+ + EL   ++Q   
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ---LHEYETELEDERKQRAL 1614

Query: 943  AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
            A    K+ E + + L+   +   +  E+  KQ+  LQ ++K             Q++L  
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-----------DFQRELED 1663

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQE 1061
            A    A+  E  +  + N +K+    K L++D    + +L A  +  K  + EK  LA+E
Sbjct: 1664 AR---ASRDEIFATAKENEKKA----KSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716

Query: 1062 --DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
                +S RN + ++ +    L+   A LE++  +++  ++     ++   ++      EL
Sbjct: 1717 LASSLSGRNALQDEKR---RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
              E+S   + E  + + E++    N+EL+S KL  ++     K    +       L+ K 
Sbjct: 1774 ATERSTAQKNESARQQLERQ----NKELRS-KLHEMEGAVKSKFKSTI-----AALEAKI 1823

Query: 1180 DSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEIKEKEVGMKKHEENEA 1237
              L+  VEQE R +Q     +K+++++LK+    +E E K+  + KE+    +K      
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ---AEKGNARVK 1880

Query: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
            +L  Q+    E    +    +  QR + E  +  + +  E+  L++ ++
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score =  222 bits (565), Expect = 2e-57
 Identities = 254/1140 (22%), Positives = 501/1140 (43%), Gaps = 118/1140 (10%)

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q    E  +     EL K  +       EL++L+   ++LT++   L E L  + + Y +
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDC-------QQLQSRLSASETSLHRIHVELSEKGEA 373
             EE     +  K+ ++  LH+ +          QQLQ+        +  +  +L E+  A
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
             QKL+ E    E K + L+ E   +  Q  +  +    L+  I+ L + L E        
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-------- 1017

Query: 434  HGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
                +E++  +  KL +K E  +++L+++L + E+  +E      +L+       +Q  +
Sbjct: 1018 ----EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
             QA       +L + + +L+  L ++ D+  +  N    +++ + +IS L+   EDL   
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ---EDL--- 1127

Query: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
                + E A  N+ +++   L E++  L  +L++  +S    QE    + QE     +A 
Sbjct: 1128 ----DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 613  QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
             +   S E  V E+  +  ++ E++++   Q K     L   +     + ADL   L   
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243

Query: 673  QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
              A Q+ + +  K+  Q+ ++ +K  D +   ++L   + + + +  S+     E EG+ 
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 733  KKLEAD--SLEVKASKEQALQDLQQQRQLNTDLELRATE-----LSKQLEMEKEI----- 780
             KL  D  SL  +    Q L   + +++LN   +LR  E     L  QL+ E E      
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363

Query: 781  --VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------EELNN 832
              +S+  + L    + L+     +   EE K+  +++ E L+Q+ + +       E+  N
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
            R+Q  + +L      +  L++ L   + K  ++    KN  S++  E  + +A     E 
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA-----EA 1478

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
              KE K    + +   L+E  E K+ LE+    +  LK E+    E L+ +++ + +N  
Sbjct: 1479 REKETK---ALSLARALEEALEAKEELER---TNKMLKAEM----EDLVSSKDDVGKNVH 1528

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
            E   L+ +   L+   E+ K Q+E L+ EL+     K  LE  +Q    Q  ++L A   
Sbjct: 1529 E---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD- 1584

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESEL----------LATRQDLKSVEEKLSLAQED 1062
                     E+++E  +QLQ   +  E+EL           A ++ L+   + L L  + 
Sbjct: 1585 ---------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 1063 LISNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
             I  R + I    KL  ++K  +  LE   A +++       A ++ +K KSL E +L+ 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKAKSL-EADLMQ 1691

Query: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL------IQQKLE- 1174
             +  LA  E  + + + E  +L EEL S    S+     L+D K+ L      ++++LE 
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIAQLEEELEE 1747

Query: 1175 ----LQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEAK-LHSEIKEKEVG 1228
                ++  +D ++ A +Q E+ + ++  ++   ++ E  ++ +E++ K L S++ E E  
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 1229 MK-KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK-------QTDDLRGEIAV 1280
            +K K +   A L  +I  L E +    +E Q++ + + + +K       Q +D R     
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
             +   +      + L  +  + E E +++     +LQR+LD  T + + +GRE  +L+ K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score =  168 bits (425), Expect = 4e-41
 Identities = 181/920 (19%), Positives = 414/920 (45%), Gaps = 70/920 (7%)

Query: 477  TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
            T+++  L  T+Q+  E+   ++    K +E Q   E  L+++  K  ++   + LLQ+  
Sbjct: 839  TKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 537  ENISLLEKEREDLYAKIQAGEGET--------AVLNQLQEKNHTLQEQVTQLTEK---LK 585
            +  + L  E E++  ++ A + E         A L + +++   LQ +  ++ ++   L+
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
             Q E  + A++ L  +    +A ++  +D +L ++   N+L+ +    +E++S L     
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-- 1014

Query: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQ 701
                  L+ E  K      L+N  ++  + L+ + ++  K   +L+++  KL+    D  
Sbjct: 1015 ------LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E  + L++ + E K   + L +K EEL+  + +L+ +     A K  AL+ +++      
Sbjct: 1069 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEI----AQKNNALKKIRE------ 1115

Query: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
             LE   ++L + L+ E+   +      +   E LE++K +L    +     ++      Q
Sbjct: 1116 -LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E  +  + L+   ++   ++Q+++ +    + EL+   ++  +   +L  +K   EKEN 
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234

Query: 882  KGKAAILDLEKTCKELKHQ---LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
                 +  L +  +E++H+   L+ Q++    +  + +++  +  +  H+L+ E+ S+  
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294

Query: 939  QLIQAQNTLKQNEKE----EQQLQGNINELKQSSEQKK------KQIEALQGELKIAVLQ 988
             L +A+    +  K+      QLQ     L++ + QK       +Q+E  +  L+  + +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG---RESELLAT 1045
            + E +  L++ ++    +L+  K+K+    +  E  +E  K+ Q +      +  E  A 
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE----QQLQER 1101
               L+  + +L    +DL+ +   + NQ +L+  L+  +   +Q  A+++    +   ER
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
             +A  +  +EK  K   L     +  E +E   R  K +    E+L S K +  K +  L
Sbjct: 1472 DRAEAEA-REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530

Query: 1162 KDAKQLLIQQ----KLELQGKADSLKAAVEQEKR---NQQILKDQVKKEEEELKKEFIEK 1214
            + +K+ L  Q    K +L+   D L+A  + + R   N Q LK Q +++ +   ++  EK
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
              +L  ++ E E  ++   +  A        L  +L  ++ +  S+ +   E  KQ   L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGREN 1334
            + ++   +  +++ +  R  +     + E + + L+  +++LQ  L     A ++   E 
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 1335 QSLQIKHTQALNRKWAEDNE 1354
            + L  +   +L+ + A  +E
Sbjct: 1711 EELAEELASSLSGRNALQDE 1730


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  244 bits (623), Expect = 4e-64
 Identities = 288/1341 (21%), Positives = 603/1341 (44%), Gaps = 147/1341 (10%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            +S+L   + +++   QE+Q+    ++E     E+LK++LE      Q   +   L+T   
Sbjct: 858  DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT--- 914

Query: 135  AELQSLEQQLEEAQT---ENFNIKQMKDLFEQKAAQLATEIAD-IKSKYDEERSLREAAE 190
               + L+Q LEE +T   E  ++KQ+++  + +  QL ++I D +    D +  LR A E
Sbjct: 915  ---EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 191  Q----------KVTRLTEELNKEATVIQ---DLKTELLQR-PGIEDVAVLKKELVQVQT- 235
                         ++++EE+++   + +   + K E  Q+  GI+    L+ +  Q  T 
Sbjct: 972  SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031

Query: 236  -LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294
             + DN  +E++R+   L  E  +LQ    S  A   QL+++L    + + + ++  ++L+
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL---KENIEMTIENQEELR 1088

Query: 295  SSVNELTQKNQTLTE---NLLKKEQDYTK-------LEEKHNEESVSKKNIQATLHQKDL 344
               +EL ++ + + +   + +KKE + ++       +EEK  E+S   +  Q  L     
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE 1148

Query: 345  DCQQLQSRLSASETSLHRI--------HVELSEKGEATQKLKEELSEVETKYQHLKAEFK 396
            +  ++Q +++  E   + +        H+E +E+ E  QKL E   EV++  +  K   K
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHME-TERLELAQKLNENYEEVKSITKERKV-LK 1206

Query: 397  QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVA 456
            +LQ+  E +  H   L+  I ++ +  L+T+ +L  AH  LKE ++   E      ++ A
Sbjct: 1207 ELQKSFETERDH---LRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA 1263

Query: 457  DLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
             +      +  Q  EK  + T+LQ ++      H+EQ+ L                  ++
Sbjct: 1264 QI------INTQDLEK--SHTKLQEEIPVL---HEEQELLPN----------------VK 1296

Query: 517  QIGDKDQKIQNLEALLQKS--KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
            ++ +  + +  LE L ++S  K++ +L   E E L               +L EK    Q
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERL---------------RLNEKFQESQ 1341

Query: 575  EQVTQLTEKLKNQSESHKQAQENLHDQVQEQ-KAHLRAAQDRVLSLETSVNELNSQLNES 633
            E++  LT K ++  ++ K+A E  HDQ++E  +  L   Q+     E S+N +  + NE+
Sbjct: 1342 EEIKSLT-KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN-MKEKDNET 1399

Query: 634  KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK----------QQEL 683
             + VS+++ Q K K   LL  E         LQ   D  ++  ++K          Q E 
Sbjct: 1400 TKIVSEME-QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
            +++   + ++ AK  + +E        LKE +E    L     E E +I  ++     + 
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518

Query: 744  ASKEQALQDL-QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
               +  +Q++ +++ Q N        E   +L+  KE   +    LQ     +  +  +L
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578

Query: 803  TKQEEEKQIL---KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
             + +EE QI+   K++ + + +  +I+ ++L    +  V ++ K   EKE    +++ V 
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM-KESQEKEYQFLKMTAVN 1637

Query: 860  DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK-TCKELKHQLQVQMENTLKEQKELKKS 918
            +   K+ + +++ K +F  E QK     ++ E     ++ H+   +M +  KE+ +L+  
Sbjct: 1638 ETQEKMCE-IEHLKEQF--ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694

Query: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
             E  K    QLK  L     + ++ Q  LK      ++ Q  I++L+    +K  +I  +
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754

Query: 979  QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
            Q +L+ +       + K+Q++L  A   L  ++E I  L+    +  +    +Q D    
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814

Query: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT---LEQDSAKKE 1095
             ++L    Q+LK+ E +L   ++D+   + ++    +L +++K    T   LE ++    
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874

Query: 1096 QQLQERCKALQDIQKEKS---LKEKELVNEKSKLAE-IEEIKCRQEKEITKLNEELKSHK 1151
            Q+L E  + ++ + KE+      E+ L  E+ +L E ++E K R      ++ +ELK+ +
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD----LEIQQELKTAR 1930

Query: 1152 LESIKEITNLKDAKQLLIQQKLELQG-KADSLKAAVEQEKRNQQILKDQVK----KEEEE 1206
            + S +    +   ++ + ++ +++   + D  K+  E +K+ Q++ K +++    KE+  
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990

Query: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
            +  + I +  +L  + + + + M+    +  +LT ++    E +  V KE    +R    
Sbjct: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES 2050

Query: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
            L+ + D     IA L   +  ++   +   E+ L  +G+          L   L    + 
Sbjct: 2051 LKMERDQF---IATLREMIARDRQNHQVKPEKRLLSDGQ--------QHLTESLREKCSR 2099

Query: 1327 VQELGRENQSLQIKHTQALNR 1347
            ++EL +    +   H + LNR
Sbjct: 2100 IKELLKRYSEMD-DHYECLNR 2119



 Score =  240 bits (612), Expect = 8e-63
 Identities = 320/1391 (23%), Positives = 623/1391 (44%), Gaps = 201/1391 (14%)

Query: 76   SNLALKRDDVTLLRQEVQDLQASL-----KEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
            S L     +V  LR+E+QD    L     +++K +SE + KE  + QGL ++  K    +
Sbjct: 747  SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE-SRVQGLLEEIGKTKDDL 805

Query: 131  TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190
              + +  +S +Q+ +       N K +   FEQK   +  E               E   
Sbjct: 806  ATTQSNYKSTDQEFQ-------NFKTLHMDFEQKYKMVLEE--------------NERMN 844

Query: 191  QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250
            Q++  L++E  K  + +  LKTEL  +        L+++  +VQ        ER  E E+
Sbjct: 845  QEIVNLSKEAQKFDSSLGALKTELSYK-----TQELQEKTREVQ--------ERLNEMEQ 891

Query: 251  LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL--------TQ 302
            LK++ +   S   + E   + +  +L +  +EV    QE   LK     L        + 
Sbjct: 892  LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951

Query: 303  KNQTLTENLLKKEQDYTKLEE-KHNEESVS------KKNIQATLHQKDLDCQ---QLQSR 352
             + T+  N+  +EQ    LE  K ++E+++       + +   LH ++   +   + Q +
Sbjct: 952  IHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK 1011

Query: 353  LSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
            +   +    +  +E       T  +K+ E+ E + K   L  E  +LQQ  E       Q
Sbjct: 1012 MVGID---KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ 1068

Query: 412  LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK---LMDKEQQVADLQLKLSRLEEQ 468
            L++++ +     +E + +L      LK+Q+++ +++    + KE +++    +L+ +EE+
Sbjct: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128

Query: 469  LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528
            LKEK     E Q QL   +++  E Q           +  N++E +  ++ +K+  ++++
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQ-----------KKINEIENLKNELKNKELTLEHM 1177

Query: 529  EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
            E       E + L +K  E+ Y ++++   E  VL +LQ+   T ++ +     +++   
Sbjct: 1178 ET------ERLELAQKLNEN-YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230

Query: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ------LNESKEKVSQLDI 642
               K+  +  H        HL+  Q+ +  L  SV+E  +Q      L +S  K+ +   
Sbjct: 1231 LQTKEELKIAH-------IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283

Query: 643  QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
             +  + ELL + +     Q    +  L T Q+  +D    L +I  +  ++  K Q+ QE
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD-STTLARIEMERLRLNEKFQESQE 1342

Query: 703  HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL------------ 750
                L       K    +LE K ++L+  I++  A   E ++ +EQ+L            
Sbjct: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKI 1402

Query: 751  -QDLQQQRQLNTDL---ELRATELSKQLEM---EKEIVSSTRLDLQKKSEALESIKQKLT 803
              +++Q +  ++ L   E+    LSK+L+    E + V+  + DLQ+  E L+S   +L 
Sbjct: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL- 1461

Query: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
             +E  K+I+ +  ET  +E K+ H  L  + + T+ EL+    EKE   TE+ST++ +L 
Sbjct: 1462 -KENIKEIVAKHLET-EEELKVAHCCLKEQ-EETINELRVNLSEKE---TEISTIQKQLE 1515

Query: 864  KVSDSLKNSKSE-FEKENQKGKAAILDLEKTCKELK----------------HQLQVQME 906
             ++D L+N   E +EKE Q     I ++++   ELK                    +++ 
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELT 1575

Query: 907  NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
            N L+E +E  + + KEKE   +++  L   ++QL +    +    KE Q+ +    ++  
Sbjct: 1576 NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635

Query: 967  SSEQKKK--QIEALQGELKIAVLQKTELENKLQQ--QLTQAAQELAAEKEKISVLQNNYE 1022
             +E ++K  +IE L+ + +    QK  LEN   +  +LTQ   E   E   ++  +++  
Sbjct: 1636 VNETQEKMCEIEHLKEQFE---TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLR 1692

Query: 1023 KSQETFK----QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR-------NQIG 1071
              +ET K    QL+ +     +  L  +++LK V   L   QE +   R       N+I 
Sbjct: 1693 SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752

Query: 1072 NQNKLIQELKTAKATLEQDSAKKEQQL----------QERCKALQDIQKEKSLK----EK 1117
            N  K   +L+ +   L+    K +++L          QE    L+ I  EK+ K    +K
Sbjct: 1753 NMQK---DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809

Query: 1118 ELVNEKSKLAE-IEEIKCRQEKEIT---KLNE-ELKSHKLESIKEITNLKDAKQLLIQQK 1172
            +L N  +KL E I+E+K  + + IT    +NE + K  ++E +K+   +KD    L + +
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK--QIKDQSLTLSKLE 1867

Query: 1173 LELQGKADSLKAAVEQ------EKRNQQILKDQVKKEEEELKKEFIEKEAK---LHSEIK 1223
            +E    A  L   +E+      E+ N + +++ +K E ++LK+   E +A+   +  E+K
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELK 1927

Query: 1224 EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL-RGEIAVLE 1282
               +  K+H+E   KL  +I+     +  ++K+   S+    EL+K+  +L + E+ +L 
Sbjct: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK---DELQKKIQELQKKELQLLR 1984

Query: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVL-----ELQRKLDNTTAAVQELGRENQSL 1337
                 N   ++      LK + E + L  + +     +L +KL  +   ++ + +E   L
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044

Query: 1338 -QIKHTQALNR 1347
             +IK +  + R
Sbjct: 2045 RRIKESLKMER 2055



 Score =  232 bits (591), Expect = 2e-60
 Identities = 326/1467 (22%), Positives = 639/1467 (43%), Gaps = 269/1467 (18%)

Query: 81   KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQE------------AKPD 127
            K+D    L  E+ +L+  +K  + Y+++L+ EL  K + L+++E             K +
Sbjct: 545  KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604

Query: 128  GLVTDSSAELQSLE------QQLEEAQT--------------ENFNIKQMKDLFEQKAAQ 167
             +  D S  L+S+E      Q L +A+T              EN  +K+          Q
Sbjct: 605  NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664

Query: 168  LATEI--------ADIKSKYDEERSLREA------------------------AEQKVTR 195
            +  +I        A  K + D E+ L+ A                         E K+T 
Sbjct: 665  MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724

Query: 196  LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL---K 252
            L +ELNKE    + L+ E+          +L  EL  + + ++ +  E + +SE+L    
Sbjct: 725  LQKELNKEVEENEALREEV----------ILLSELKSLPSEVERLRKEIQDKSEELHIIT 774

Query: 253  DECKKLQSQYASSEATISQLRSELAKGPQEVAVYV-------QELQKLKSSVNELTQKNQ 305
             E  KL S+    E+ +  L  E+ K   ++A          QE Q  K+   +  QK +
Sbjct: 775  SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834

Query: 306  TLTE----------NLLKKEQDY--------TKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
             + E          NL K+ Q +        T+L  K  E     + +Q  L++ +   +
Sbjct: 835  MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
            QL++R S  +T      VE  EK   T+KL++ L EV+T  Q  K + KQLQ+  + +  
Sbjct: 895  QLENRDSTLQT------VE-REKTLITEKLQQTLEEVKTLTQE-KDDLKQLQESLQIERD 946

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
               QL+S+I+   +  ++T+ QL  A   LK+ ++                   ++ L+ 
Sbjct: 947  ---QLKSDIHDTVNMNIDTQEQLRNALESLKQHQE------------------TINTLKS 985

Query: 468  QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG-DKDQKIQ 526
            ++ E+V+ +  ++    +TK + Q+                       + +G DK Q ++
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQ-----------------------KMVGIDKKQDLE 1022

Query: 527  --NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
              N + L    K+N  ++E++R+ +++ IQ         N+LQ+   ++  +  QL   L
Sbjct: 1023 AKNTQTLTADVKDN-EIIEQQRK-IFSLIQE-------KNELQQMLESVIAEKEQLKTDL 1073

Query: 585  KNQSESHKQAQENLH---DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
            K   E   + QE L    D++++Q+  +   ++  +  E  ++    +L E +EK+ +  
Sbjct: 1074 KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS 1133

Query: 642  IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
             Q++ K + LL+ +   +  +  + N ++  +N L++K+  L  + T+  ++  KL +  
Sbjct: 1134 QQLQEKQQQLLNVQEEMSEMQKKI-NEIENLKNELKNKELTLEHMETERLELAQKLNENY 1192

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E    +    K  KE   S E + + L G I+++EA  L+ K   + A   L++ ++   
Sbjct: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252

Query: 762  DLELRATELSKQLEMEKEIVSS-TRLD-----LQKKSEALESIKQKLTKQE--EEKQILK 813
            +L    +E + Q+   +++  S T+L      L ++ E L ++K+    QE   E ++L 
Sbjct: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312

Query: 814  QDFETLSQET----KIQHEELNNRIQTTVTELQKVKMEKEALMTELST-----------V 858
            +   T    T    +++   LN + Q +  E++ +  E++ L T               +
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHI 1372

Query: 859  KDKLSKVSDSLKNSKSEF---EKENQKGK------------AAILDLEKTCKELKHQLQV 903
            ++ L+K+ +S    +      EK+N+  K            +A+L +E     L  +LQ 
Sbjct: 1373 RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

Query: 904  ---QMENTLKEQKELKKSLEKEKEASHQLKLELNSM-------QEQLIQAQNTLKQNEKE 953
               +M++  KE+ +L++  E  +  S QLK  +  +       +E+L  A   LK+ E+ 
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492

Query: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE--------NKLQQQLTQAAQ 1005
              +L+ N++E +      +KQ+EA+  +L+  + +  E E        +++Q+++ +  Q
Sbjct: 1493 INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ 1552

Query: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
                 K K S LQ+   K  E   +LQ +       ++  ++++K V+E L + ++ L  
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRLQ-ESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611

Query: 1066 NRNQI-----GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA----LQDIQKE----- 1111
            N  +I      +Q K  Q LK       Q+   + + L+E+ +     L++I+ E     
Sbjct: 1612 NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671

Query: 1112 ----KSLKE-KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI----TNLK 1162
                ++L+E + +  E+  L  +EE    +  ++ +   E  +  LE  +E+     +LK
Sbjct: 1672 QILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK---------KEFIE 1213
            + ++ + + +  +  K + +    +  + +   LK Q  K +EEL+         +E I+
Sbjct: 1732 EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791

Query: 1214 KEAKLHSEIKEKEVGMKKHEEN-EAKLTMQITALNEN---LGTVKKEWQSSQRRVSELE- 1268
            K   + SE  +K   M+K  EN  AKL  +I  L  N   L T+KK+   +Q++VSE+E 
Sbjct: 1792 KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQ 1851

Query: 1269 --KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
              KQ  D    ++ LE    N   +    LE       E + L+     L+ + D    +
Sbjct: 1852 LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911

Query: 1327 VQELGRENQSLQ--IKHTQALNRKWAE 1351
            +QE    +  +Q  +K  + L+++  E
Sbjct: 1912 LQETKARDLEIQQELKTARMLSKEHKE 1938



 Score =  204 bits (519), Expect = 5e-52
 Identities = 290/1396 (20%), Positives = 594/1396 (42%), Gaps = 242/1396 (17%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            ES +A K    T L++ ++    + +E +   +ELKK+ E     +    K +G ++ + 
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
              L  +E++L+E +++    KQ      Q+   +  E+++++ K +E           + 
Sbjct: 1120 DRLAEVEEKLKE-KSQQLQEKQ------QQLLNVQEEMSEMQKKINE-----------IE 1161

Query: 195  RLTEELNKEATVIQDLKTELLQ-----RPGIEDVAVLKKELVQVQTLMDNMTLERE---- 245
             L  EL  +   ++ ++TE L+         E+V  + KE   ++ L  +   ER+    
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221

Query: 246  --RESE----KLKDECKKLQSQYASSEATISQLRSELAKGP----------------QEV 283
              RE E    + K+E K         + TI +LR  +++                  QE 
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281

Query: 284  AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK----------------------- 320
               + E Q+L  +V E+++  +T+ E  L  EQ  TK                       
Sbjct: 1282 IPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341

Query: 321  -------------------LEEKHN-------------EESVSKKNIQATLHQKDLDCQQ 348
                               LE KH+             +ES SK+     + +KD +  +
Sbjct: 1342 EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401

Query: 349  LQSRL---SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK 405
            + S +      +++L RI +E+    +  Q+  +E+  V         E   LQ+ +E  
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV-------AKEKDDLQRLQEVL 1454

Query: 406  EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLMDKEQQVADLQLKL 462
            +    QL+  I ++ +K LETE +L  AH  LKEQ +  +E    L +KE +++ +Q +L
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514

Query: 463  SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD 522
              + ++L+ K+             ++ +++++       ++++E  N+L+Q       KD
Sbjct: 1515 EAINDKLQNKI-------------QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561

Query: 523  QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582
              +Q++E+   K  E  + L++ +E++   I+  E    V   LQ +   L+E   ++  
Sbjct: 1562 SALQSIES---KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618

Query: 583  KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642
            K+K   E   Q           +   +   Q+++  +E     L  Q    K  +  ++ 
Sbjct: 1619 KMKESQEKEYQFL---------KMTAVNETQEKMCEIE----HLKEQFETQKLNLENIET 1665

Query: 643  QIKAKTELL---LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699
            +    T++L   L    + T +R DL++  +T        + E +++   L +   +  +
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETL-------KVERDQLKENLRETITRDLE 1718

Query: 700  KQEHCSQLESHLKEYKEKYLSL----EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
            KQE    +  HLKE++E    L     +KT E+    K LE  +  +KA      QDL+ 
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKA------QDLKI 1772

Query: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
            Q +L     +   E  + ++  + IVS     L    + LE+   KL ++ +E +  +  
Sbjct: 1773 QEELRI-AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831

Query: 816  FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK----DKLSKVSDSLKN 871
              TL ++         N  Q  V+E++++K + +     LS ++    +   K+ ++L+ 
Sbjct: 1832 LITLKKDV--------NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883

Query: 872  SKSEF-EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
             KS   E++N +     L LE+   +LK  LQ      L+ Q+ELK +    KE    + 
Sbjct: 1884 MKSVMKERDNLRRVEETLKLER--DQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941

Query: 931  LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990
                 + E+ IQ  +  K  +K + +LQ  I EL      +KK+++ L+      V +  
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQEL------QKKELQLLR------VKEDV 1989

Query: 991  ELENKLQQQLTQAAQELAAEKEKI-SVLQNNYEKSQETFKQLQSDFYGRESELLA-TRQD 1048
             + +K   ++ Q  ++  A+   + SV  +N++ +++  + L+      E  ++A  R +
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE------EIRIVAKERDE 2043

Query: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
            L+ ++E L + ++  I+   ++  +++   ++K  K  L        + L+E+C  ++++
Sbjct: 2044 LRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKEL 2103

Query: 1109 QKEKSLKEK--ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166
             K  S  +   E +N  S   E +EI+ ++E  + ++   L    L++ K I  L  A Q
Sbjct: 2104 LKRYSEMDDHYECLNRLSLDLE-KEIEFQKELSM-RVKANLSLPYLQT-KHIEKLFTANQ 2160

Query: 1167 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIK--E 1224
                +   +  K   + + V + K  Q    + + K E +   E +EK+ +L  +I+  +
Sbjct: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQH---ESINKFEMDFIDE-VEKQKELLIKIQHLQ 2216

Query: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284
            ++  +   E  + KL      ++ ++  + K++  S+    + E Q              
Sbjct: 2217 QDCDVPSRELRDLKLNQN---MDLHIEEILKDFSESEFPSIKTEFQ-------------Q 2260

Query: 1285 VQNNQDERRALLERCLKGEGEIEKLQT-------KVLELQRKLDNTTAAVQELGRENQSL 1337
            V +N+ E    LE  L    +IEKL+        ++ ++    +N   A+      N+S 
Sbjct: 2261 VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIM-----NEST 2315

Query: 1338 QIKHTQA-LNRKWAED 1352
            + +   A ++++W +D
Sbjct: 2316 EFEERSATISKEWEQD 2331



 Score =  194 bits (492), Expect = 7e-49
 Identities = 271/1306 (20%), Positives = 561/1306 (42%), Gaps = 142/1306 (10%)

Query: 90   QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
            Q  Q+   ++KE+   + ++  E+E+++       + +  +   S  LQ    +++    
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442

Query: 150  ENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-ERSLREA------AEQKVTRLTEELNK 202
            E  ++++++++ + ++ QL   I +I +K+ E E  L+ A       E+ +  L   L++
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSE 1502

Query: 203  EATVIQDLKTEL------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
            + T I  ++ +L      LQ   I+++   K+E   ++ + +    E+  E ++ K+  K
Sbjct: 1503 KETEISTIQKQLEAINDKLQNK-IQEIYE-KEEQFNIKQISE--VQEKVNELKQFKEHRK 1558

Query: 257  KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
               S   S E+ + +L + L +  +E+ + ++E +++K     L  +   L EN   KE 
Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT--KEI 1616

Query: 317  DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-------LSE 369
                 E +  E    K        +K  + + L+ +    + +L  I  E       L E
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676

Query: 370  KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
              E  + + +E  ++ +  + LK E  QL++   E     L+ Q E+  +H  L E +  
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736

Query: 430  LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489
            + +  G + E+    S    D E     L+ +  +++E+L+    +  E Q  +DK +  
Sbjct: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR-- 1794

Query: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
                  +    T KL   Q DLE    ++ +K Q+++  E  L   K++++  +K+  ++
Sbjct: 1795 -----GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849

Query: 550  YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN---QSESHKQAQENLHDQVQEQK 606
                +  + ++  L++L+ +N  L +++ +  E++K+   + ++ ++ +E L  +  + K
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK 1909

Query: 607  AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ 666
              L+  + R L ++  +        E KE V +L  +I           + KT Q +D+Q
Sbjct: 1910 ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKI-----------SEKTIQISDIQ 1958

Query: 667  NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
              LD +++ LQ K QEL K   QL +V   +    +  +++E   K+++ + LS++    
Sbjct: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018

Query: 727  ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
            +     KKL     E++       ++  + R++   L++   +    L   +E+++  R 
Sbjct: 2019 DNFQLTKKLHESLEEIRI----VAKERDELRRIKESLKMERDQFIATL---REMIARDRQ 2071

Query: 787  DLQKKSE--ALESIKQKLTKQEEEK-QILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
            + Q K E   L   +Q LT+   EK   +K+  +  S+     H E  NR+   +   ++
Sbjct: 2072 NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD--DHYECLNRLSLDLE--KE 2127

Query: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL-- 901
            ++ +KE  M     VK  LS      K+     EK     +   ++  +  K+LK+ L  
Sbjct: 2128 IEFQKELSM----RVKANLSLPYLQTKH----IEKLFTANQRCSMEFHRIMKKLKYVLSY 2179

Query: 902  -----QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
                 + Q E+  K + +    +EK+KE    L +++  +Q+        L+ + K  Q 
Sbjct: 2180 VTKIKEEQHESINKFEMDFIDEVEKQKE----LLIKIQHLQQDCDVPSRELR-DLKLNQN 2234

Query: 957  LQGNINE-LKQSSEQKKKQIEALQGELKIAVLQKTELENKL--QQQLTQAAQELAAEKEK 1013
            +  +I E LK  SE +   I             KTE +  L  ++++TQ  +E    +  
Sbjct: 2235 MDLHIEEILKDFSESEFPSI-------------KTEFQQVLSNRKEMTQFLEEWLNTRFD 2281

Query: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
            I  L+N  +K  +   Q+ + F  R   ++A   +    EE+ +   ++   +   +  +
Sbjct: 2282 IEKLKNGIQKENDRICQVNNFFNNR---IIAIMNESTEFEERSATISKEWEQDLKSLKEK 2338

Query: 1074 N-KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132
            N KL +  +T K +L   S  +     +  K      +   L  +++   ++ L E +E 
Sbjct: 2339 NEKLFKNYQTLKTSLA--SGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES 2396

Query: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
               +E +I K+ +EL         E+TN   AK         LQ K       +E+ K  
Sbjct: 2397 AMHKESKIIKMQKEL---------EVTNDIIAK---------LQAKVHESNKCLEKTKET 2438

Query: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
             Q+L+D+V    +  K+E  + + KL     EK    K+ E+  +     +    E +  
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRL 2498

Query: 1253 VKKEWQSSQRR--VSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
            +++  + SQ+    S + + TD                Q   + L   C  G G ++   
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDP---------------QPSNKPL--TCGGGSGIVQ--N 2539

Query: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
            TK L L+ +       + +L ++N+ L  +  + L+      NEV+
Sbjct: 2540 TKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK 2585



 Score =  186 bits (473), Expect = 1e-46
 Identities = 261/1195 (21%), Positives = 519/1195 (43%), Gaps = 174/1195 (14%)

Query: 197  TEELNKEATVIQDLKT-ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL--KD 253
            T +  K    + ++ T E L +   +++  LKK+L +V        +E+++ ++ L  KD
Sbjct: 325  TAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKD 384

Query: 254  ECKKLQSQ---------YASSEATISQLRSEL-AKGPQEVAVYVQELQKLKSS------- 296
              +K+Q++           SS  T+ Q   EL AK  + V   + ++ K+K+S       
Sbjct: 385  LLQKVQNEKIENLTRMLVTSSSLTLQQ---ELKAKRKRRVTWCLGKINKMKNSNYADQFN 441

Query: 297  -VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
                +T K   L+ NLL++            +ESV     ++ +    LD          
Sbjct: 442  IPTNITTKTHKLSINLLREI-----------DESVCS---ESDVFSNTLD---------- 477

Query: 356  SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
               +L  I    + K    + ++ EL+ +   Y +L  +++QL+ ++EE E         
Sbjct: 478  ---TLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMEL-------- 526

Query: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSS-EKLMDKEQQVADLQL--KLSRLEEQLKEK 472
                                +LKE+  L   E L  K ++  ++QL  ++S L+  +K  
Sbjct: 527  --------------------KLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA 566

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
               + +L+++L               S    LRE ++ ++++   I    QK++N++  L
Sbjct: 567  EVYNQDLENELS--------------SKVELLREKEDQIKKLQEYIDS--QKLENIKMDL 610

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
              S E+I   ++ ++ L+      + ET  L+  +E      E + +L EK+K  + ++K
Sbjct: 611  SYSLESIEDPKQMKQTLF------DAETVALDAKRESAFLRSENL-ELKEKMKELATTYK 663

Query: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
            Q    + + +Q  ++ L A +   + LE    EL S  NE  +  S +D ++       L
Sbjct: 664  Q----MENDIQLYQSQLEAKKKMQVDLE---KELQSAFNEITKLTSLIDGKVPKDLLCNL 716

Query: 653  SAEAAKTAQRADLQNHLDTAQNALQDKQ---QELNKITTQLDQVTAKLQDKQEHCSQLES 709
              E   T  + +L   ++  + AL+++     EL  + ++++++  ++QDK E    + S
Sbjct: 717  ELEGKITDLQKELNKEVEENE-ALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITS 775

Query: 710  HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
               +   + +  E + + L  +I K + D    +++ +   Q+ Q  + L+ D E +   
Sbjct: 776  EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM 835

Query: 770  LSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
            + ++ E M +EIV+ ++ + QK   +L ++K +L+ + +E Q   ++ +    E +   E
Sbjct: 836  VLEENERMNQEIVNLSK-EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894

Query: 829  ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
            +L NR  T  T  ++  +  E L   L  VK  L++  D LK  +   + E  + K+ I 
Sbjct: 895  QLENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQESLQIERDQLKSDIH 953

Query: 889  DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE--KEASHQLKLELNS------MQEQL 940
            D      + + QL+  +E +LK+ +E   +L+ +  +E S  L +E N+       Q+++
Sbjct: 954  DTVNMNIDTQEQLRNALE-SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012

Query: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKK-----KQIEALQGELKIAVLQKTELENK 995
            +          K  Q L  ++ + +   +Q+K     ++   LQ  L+  + +K +L+  
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTD 1072

Query: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
            L++ +    +     +E++ +L +  +K QE   Q ++    +E EL  T   L  VEEK
Sbjct: 1073 LKENIEMTIE----NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128

Query: 1056 -------LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
                   L   Q+ L++ + ++    K I E++  K  L+      E    ER +  Q +
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKL 1188

Query: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI--TNLKDAKQ 1166
              E   + K +  E+  L           KE+ K  E  + H    I+EI  T L+  ++
Sbjct: 1189 -NENYEEVKSITKERKVL-----------KELQKSFETERDHLRGYIREIEATGLQTKEE 1236

Query: 1167 LLIQ--QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF--IEKEAKLHSEI 1222
            L I      E Q   D L+ +V  EK  Q I    ++K   +L++E   + +E +L   +
Sbjct: 1237 LKIAHIHLKEHQETIDELRRSV-SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295

Query: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKE-------WQSSQRRVSELEKQTDDLR 1275
            KE     +   E E       T  +  L  ++ E       +Q SQ  +  L K+ D+L+
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355

Query: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
                 ++  ++   D+ +  +   L    E +  Q + L ++ K + TT  V E+
Sbjct: 1356 ----TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM 1406



 Score =  155 bits (393), Expect = 2e-37
 Identities = 219/992 (22%), Positives = 444/992 (44%), Gaps = 163/992 (16%)

Query: 461  KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
            ++S  E  LK       +L+ QL++   + + Q A+++   A+L E ++ L++V      
Sbjct: 337  EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQ-AMEKDQLAQLLEEKDLLQKV------ 389

Query: 521  KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ----EQ 576
            +++KI+NL  +L  S  +++L ++ +     ++    G+   +N+++  N+  Q      
Sbjct: 390  QNEKIENLTRMLVTSS-SLTLQQELKAKRKRRVTWCLGK---INKMKNSNYADQFNIPTN 445

Query: 577  VTQLTEKLK------------NQSESHKQAQENL-------------HDQVQEQKAHLRA 611
            +T  T KL             ++S+      + L              + ++ +   LRA
Sbjct: 446  ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA 505

Query: 612  AQDRVL----SLETSVNELNSQLNESKE--KVSQLDIQIKAKTELLLSAEAAKTAQ---- 661
              D ++     L T   E+  +L E  +  +   L+ + K   E+ L  E +        
Sbjct: 506  DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKH 565

Query: 662  ----RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD-KQEHCSQLES--HLKEY 714
                  DL+N L +    L++K+ ++ K+   +D  + KL++ K +    LES    K+ 
Sbjct: 566  AEVYNQDLENELSSKVELLREKEDQIKKLQEYID--SQKLENIKMDLSYSLESIEDPKQM 623

Query: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK-- 772
            K+     E    + + +   L +++LE+K   E+  +     +Q+  D++L  ++L    
Sbjct: 624  KQTLFDAETVALDAKRESAFLRSENLELK---EKMKELATTYKQMENDIQLYQSQLEAKK 680

Query: 773  --QLEMEKEIVSS--------------------TRLDLQKKSEALESIKQKLTKQEEEKQ 810
              Q+++EKE+ S+                      L+L+ K   +  ++++L K+ EE +
Sbjct: 681  KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK---ITDLQKELNKEVEENE 737

Query: 811  ILKQDFETLSQETKI--QHEELNNRIQTTVTELQKVKMEKEALMTEL-------STVKDK 861
             L+++   LS+   +  + E L   IQ    EL  +  EK+ L +E+         + ++
Sbjct: 738  ALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE 797

Query: 862  LSKVSDSLKNSKSEF---EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
            + K  D L  ++S +   ++E Q  K   +D E+  K +  +     E   +E   L K 
Sbjct: 798  IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE----NERMNQEIVNLSKE 853

Query: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
             +K   +   LK EL+   ++L          +++ +++Q  +NE+    EQ K+Q+E  
Sbjct: 854  AQKFDSSLGALKTELSYKTQEL----------QEKTREVQERLNEM----EQLKEQLENR 899

Query: 979  QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
               L+    +KT +  KLQQ L +  + L  EK+ +  LQ + +  ++   QL+SD +  
Sbjct: 900  DSTLQTVEREKTLITEKLQQTLEEV-KTLTQEKDDLKQLQESLQIERD---QLKSDIHDT 955

Query: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ--NKLIQELKTAKATLE-------- 1088
             +  + T++ L++  E L   QE + + +++I  +    L  E  T +   E        
Sbjct: 956  VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015

Query: 1089 ---QD-SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE-IEEIKCRQEKEITKL 1143
               QD  AK  Q L    K  + I++++ +    L+ EK++L + +E +   +E+  T L
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS--LIQEKNELQQMLESVIAEKEQLKTDL 1073

Query: 1144 NEELKSHKLESIKEIT----NLKDAKQLLIQQKL-------ELQGKADSLKAAVEQEKRN 1192
             E ++   +E+ +E+      LK  ++++ Q+K        EL    D L    E+ K  
Sbjct: 1074 KENIEM-TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132

Query: 1193 QQILKDQ------VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1246
             Q L+++      V++E  E++K+  E E  L +E+K KE+ ++  E    +L  ++   
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIE-NLKNELKNKELTLEHMETERLELAQKLNEN 1191

Query: 1247 NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI 1306
             E + ++ KE +  +      E + D LRG I  +EAT    ++E +       + +  I
Sbjct: 1192 YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251

Query: 1307 EKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
            ++L+  V E   ++ NT    Q+L + +  LQ
Sbjct: 1252 DELRRSVSEKTAQIINT----QDLEKSHTKLQ 1279


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  228 bits (580), Expect = 4e-59
 Identities = 249/1139 (21%), Positives = 526/1139 (46%), Gaps = 113/1139 (9%)

Query: 164  KAAQLATEIADIKSKYDEER-------SLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216
            K+A+   E+A +K  ++  +       + R+  E+K+  L +E N     +Q  +TE L 
Sbjct: 845  KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQS-ETENLM 903

Query: 217  RPGIEDVAVLKKELV---QVQTLMDNMTLERERESE------KLKDECKKLQSQYASSEA 267
                    ++K +++   +V+ L + +  E E  SE       L+D+C  L+      E 
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963

Query: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327
            T++++  E      +V    +E+  L+ ++++LT++ ++L E   +   D    E+K N 
Sbjct: 964  TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN- 1022

Query: 328  ESVSKKNIQATLHQKDLD--CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
              + K N +      DL+   +Q +   +  E +  ++  +L    E+   L+ +  ++E
Sbjct: 1023 -GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIE 1081

Query: 386  TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH---GRLKEQRQ 442
             K +  + E  QLQ + ++++ H LQ Q +I +L +++ E E ++   H    ++++QR 
Sbjct: 1082 EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRS 1141

Query: 443  LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
              + +L +  +++ +     S   E  K++     +++  L++   QH       ++T A
Sbjct: 1142 DLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH-------EATAA 1194

Query: 503  KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
             LR+ Q D       + +  ++I NL+ + QK ++  S L+ E +D+ + I+A    +  
Sbjct: 1195 TLRKKQAD------SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA---LSKS 1245

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
             + ++    T+++Q +++  K + Q++        +HD +  QKA L+     +      
Sbjct: 1246 KSNIERTCRTVEDQFSEIKAKDEQQTQL-------IHD-LNMQKARLQTQNGELSHRVEE 1297

Query: 623  VNELNSQLNESKEKVSQ----LDIQIKAKTELLLSAEAAKTAQRAD---LQNHLDTAQNA 675
               L SQL +SK+ ++Q    L  Q++ +T+   +   A  + R D   L+   +  Q A
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 676  LQDKQQELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
              + Q+ L+K  +++ Q   K + D  +   +LE   K+  ++    E+ TE    +   
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417

Query: 735  LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
            LE     ++   E  ++DL++       L+ +     K L   K+ +  ++ +L+   + 
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477

Query: 795  LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE---LNNRIQTTVTELQKVKMEKEAL 851
              S+  +L K     + +    ETL +E K   EE   L  +I  T   LQ+ +  K+ +
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537

Query: 852  MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
              E S ++  L +V  SL++ +S+  +   +      +L++   E   +++    N+ + 
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597

Query: 912  QKELKKSLEKE-KEASHQLKL------ELNSMQEQLIQAQNTLKQNEKEEQQLQG----- 959
             + L+  L+ E +  +  L+L      +LN M+ QL  +   + + +K  + +QG     
Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS 1657

Query: 960  --NINELKQSSEQKKKQIEALQ----------GELKIAVLQKTELENKLQQQLTQAAQEL 1007
              ++++  +S+E  K+Q+  ++           E+K+A L++TE   +L +      QEL
Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA-LEQTERTRRLSE------QEL 1710

Query: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
                +++ +L +       T K+L++D    ++E+  + Q+ ++ EEK   A  D     
Sbjct: 1711 LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770

Query: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK--EKELVNEKSK 1125
             ++  +      L+  K  LEQ     + +L E         ++ +LK  +K++   +++
Sbjct: 1771 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--------AEQLALKGGKKQIQKLENR 1822

Query: 1126 LAEIE-EIKCRQEKEITKLNEELKSHKLE-SIKEITNL--KDAKQLLIQQKL--ELQGKA 1179
            + E+E E+   Q++    L     +HK E  +KE+T    +D K +L  Q L  +LQ K 
Sbjct: 1823 VRELENELDVEQKRGAEALK---GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKV 1879

Query: 1180 DSLKAAVE--QEKRNQQILK-DQVKKEEEELKKEFIEKEAKLHS-EIKEKEVGMKKHEE 1234
             S K   E  +E+ N Q+ +  +V+ E EE  +     E++++    K ++VG +K EE
Sbjct: 1880 KSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938



 Score =  199 bits (507), Expect = 1e-50
 Identities = 236/1139 (20%), Positives = 488/1139 (42%), Gaps = 128/1139 (11%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E+E   +K++ ++ + + A SEA   +L  ++    QE      ++Q    ++ +  +
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            + + L ++ +  E    +L E+  EE      + A     +  C  L+  +   E +L +
Sbjct: 908  RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EE++ +E     L  E K LQ+  ++        + ++N L   
Sbjct: 968  VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027

Query: 423  LLETERQLGEAHGRLKEQRQLSSE----------KLMDKEQQVADLQLKLSRLEEQLKEK 472
              + E+Q  +  G L+++++L ++           L   ++ + DL+    ++EE+LK+K
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK 1087

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
                ++LQ ++D       ++Q        K++E Q  +E++       +++I+    L 
Sbjct: 1088 EFELSQLQAKID-------DEQVHSLQFQKKIKELQARIEEL-------EEEIEAEHTLR 1133

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH-------------TLQEQVTQ 579
             K ++  S L +E E++  +++   G T+   ++ +K               TLQ + T 
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193

Query: 580  LTEKLKNQSESHKQAQENLHD------QVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
             T + K Q++S  +  E + +      +++++K+ L+   D + S   ++++  S +  +
Sbjct: 1194 ATLR-KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERT 1252

Query: 634  KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
               V     +IKAK E           Q+A LQ       + +++K+  ++++T     +
Sbjct: 1253 CRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL 1312

Query: 694  TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
            T +L++ +    Q+E   K       +L+    + +  +++   +  E KA  ++AL   
Sbjct: 1313 TQQLEELKR---QMEEETKAKNAMAHALQSSRHDCD-LLREQYEEEQEAKAELQRALSKA 1368

Query: 754  QQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
              +  Q  T  E  A + +++LE  K+ ++     LQ+  E  E+   K    E+ KQ L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQR---LQEAEENTETANSKCASLEKTKQRL 1425

Query: 813  KQDFETLSQETKIQH-----------------EELNNRIQTTVTELQKVKMEKEALMTEL 855
            + + E L ++ +  H                  E   ++  +  EL+  + E  +L TEL
Sbjct: 1426 QGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL 1485

Query: 856  STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
              +++   +V D L+       +EN+  +  I DL +   E    LQ        E ++ 
Sbjct: 1486 FKMRNAYEEVVDQLET----LRRENKNLQEEISDLTEQIAETGKNLQ--------EAEKT 1533

Query: 916  KKSLEKEKE----ASHQLKLELNSMQEQLIQAQNTLKQNEKE-EQQLQGNINELKQSSEQ 970
            KK +E+EK     A  +++  L   + ++++ Q  L Q + E ++++     E++Q    
Sbjct: 1534 KKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRN 1593

Query: 971  KKKQIEALQGELKIAVLQKTE---LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
             ++  EALQ  L   +  + +   L+ K++  L +   +L     +++  Q +    Q  
Sbjct: 1594 SQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ 1653

Query: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
             K  Q        + L + +DLK         Q  ++  RN +     L++EL+  K  L
Sbjct: 1654 LKDSQLHL----DDALRSNEDLKE--------QLAIVERRNGL-----LLEELEEMKVAL 1696

Query: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEE 1146
            EQ    +    QE   A   +Q   S +   L+N K KL A+I + +   E  I    +E
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHS-QNTSLINTKKKLEADIAQCQAEVENSI----QE 1751

Query: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV---- 1200
             ++ + ++ K IT   DA  +  + K E    A  + +K  +EQ  ++ Q   D+     
Sbjct: 1752 SRNAEEKAKKAIT---DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808

Query: 1201 ----KKEEEELKKEFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENLGTV 1253
                KK+ ++L+    E E +L  E K   E   G  K+E    ++T Q    ++N+  +
Sbjct: 1809 LKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRL 1868

Query: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
            +      Q +V   ++Q ++   +     +  +  Q E     ER    E ++ KL+ K
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927



 Score =  184 bits (467), Expect = 5e-46
 Identities = 214/970 (22%), Positives = 420/970 (43%), Gaps = 103/970 (10%)

Query: 447  KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
            K  + E+++A ++    R +E+L        EL+ ++    Q+  + Q   QS T  L +
Sbjct: 845  KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904

Query: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKE-NISLLEKER--EDLYAKIQAGEGETAV- 562
            A+   E +++     + K++ L   L++ +E N  L+ K+R  ED  + ++    +  + 
Sbjct: 905  AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
            L +++++ H  +        K+KN SE     +EN+    +E+K+   A Q  +  L+  
Sbjct: 965  LTKVEKEKHATE-------NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017

Query: 623  VNELNSQLN---ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
             +++N  +    + +++   L+  ++ + +L    E AK     DL+   ++  +   DK
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077

Query: 680  QQ---ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE-------ELE 729
            QQ   +L K   +L Q+ AK+ D+Q H  Q +  +KE + +   LE++ E       ++E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137

Query: 730  GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
             Q   L  +  E+    E+A      Q ++N   E    ++ + LE       +T   L+
Sbjct: 1138 KQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197

Query: 790  KKS-----------EALESIKQKLTKQEEEKQI----LKQDFETLS-------------- 820
            KK            + L+ +KQKL K++ E ++    +  + E LS              
Sbjct: 1198 KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE 1257

Query: 821  -----------QETKIQHEELN---NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
                       Q+T++ H +LN    R+QT   EL     EKE+L+++L+  K  L++  
Sbjct: 1258 DQFSEIKAKDEQQTQLIH-DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQL 1316

Query: 867  DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926
            + LK    E  K       A+      C  L+ Q + + E   + Q+ L K+    + A 
Sbjct: 1317 EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKA--NSEVAQ 1374

Query: 927  HQLKLELNSMQ--EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
             + K E +++Q  E+L +A+  L Q  +E ++     N    S E+ K++++    +L  
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMR 1434

Query: 985  AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
             + +       L ++     + LA  K+K+   Q   E +Q+  + L ++ +   +    
Sbjct: 1435 DLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEE 1494

Query: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
                L+++  +    QE++     QI    K +QE +  K  +EQ+ +  +  L+E   +
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554

Query: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI--KEITNLK 1162
            L+  + +    + EL   KS+L + + I+  +E E  K N +  +  L+S+   EI +  
Sbjct: 1555 LEHEESKILRVQLELSQVKSEL-DRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE- 1221
            DA +L    K +++G  + ++  +    R     +  ++  + +LK   +  +  L S  
Sbjct: 1614 DALRL----KKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669

Query: 1222 -------IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD- 1273
                   I E+  G+   E  E K+ ++ T     L   ++E   +  RV  L  Q    
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS--EQELLDASDRVQLLHSQNTSL 1727

Query: 1274 ------LRGEIAVLEATVQNNQDERRALLERCLKG-------EGEIEKLQTKVLELQRKL 1320
                  L  +IA  +A V+N+  E R   E+  K          E++K Q     L+R  
Sbjct: 1728 INTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1787

Query: 1321 DNTTAAVQEL 1330
             N    V++L
Sbjct: 1788 KNLEQTVKDL 1797



 Score =  176 bits (447), Expect = 1e-43
 Identities = 208/991 (20%), Positives = 462/991 (46%), Gaps = 117/991 (11%)

Query: 72   HGGESNLALKRDDVTLLRQEVQDL---QASLKEEKWYS-EELKKELEKYQGLQQQEAKPD 127
            H  E+ +    +++T L + +  L   + SL+E    + ++L+ E +K  GL +  AK +
Sbjct: 973  HATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLE 1032

Query: 128  GLVTDSSAELQS--------------LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA 173
                D    L+               LE  L+ +Q    +++  K   E+K  +   E++
Sbjct: 1033 QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092

Query: 174  DIKSKYDEER--SLR-----EAAEQKVTRLTEELNKEATV---IQDLKTELLQRPGIEDV 223
             +++K D+E+  SL+     +  + ++  L EE+  E T+   I+  +++L +   +E++
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE--LEEI 1150

Query: 224  AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283
            +   +E     +    M  +RE E +K++ + ++   Q+   EAT + LR + A    E+
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH---EATAATLRKKQADSVAEL 1207

Query: 284  AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
               +  LQ++K  + +  +K++      LK E D   +       S SK NI+ T    +
Sbjct: 1208 GEQIDNLQRVKQKLEK--EKSE------LKMEID--DMASNIEALSKSKSNIERTCRTVE 1257

Query: 344  LDCQQLQSRLSASETSLHRIHVE----LSEKGEATQKLKEE---LSEVETKYQHLKAEFK 396
                +++++       +H ++++     ++ GE + +++E+   +S++    Q L  + +
Sbjct: 1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE 1317

Query: 397  QLQQQREEKEQ------HGLQ--------LQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
            +L++Q EE+ +      H LQ        L+ +  +      E +R L +A+  + + R 
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT 1377

Query: 443  LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ-----QALQ 497
                  + + +++ + + KL++  ++ +E    +      L+KTKQ+ Q +     + L+
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437

Query: 498  QSTT--AKLREAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
            +S T  A L + Q + ++VL +   K D+    LEA  QK   ++S       +L+    
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA-AQKESRSLS------TELFKMRN 1490

Query: 555  AGEGETAVLNQLQEKNHTLQEQVTQLTEKL----KNQSESHK------QAQENLHDQVQE 604
            A E     L  L+ +N  LQE+++ LTE++    KN  E+ K      Q + +L   ++E
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550

Query: 605  QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI-KAKTELLLSAEAAKTAQRA 663
             +  L   + ++L ++  ++++ S+L+    KV + D +I + K     +AEA ++   A
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELD---RKVIEKDEEIEQLKRNSQRAAEALQSVLDA 1607

Query: 664  DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
            ++++  D A    +  + +LN++  QL     ++ + Q+H   ++  LK+ +       +
Sbjct: 1608 EIRSRND-ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666

Query: 724  KTEELEGQIKKLEADS---LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
              E+L+ Q+  +E  +   LE     + AL+  ++ R+L+    L A++  + L  +   
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726

Query: 781  VSSTRLDL-----QKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH------EE 829
            + +T+  L     Q ++E   SI++    +E+ K+ +  D   +++E K +       E 
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLER 1785

Query: 830  LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL- 888
            +   ++ TV +LQ    E E L   L   K ++ K+ + ++  ++E + E ++G  A+  
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843

Query: 889  --DLEKTCKELKHQLQVQMENTLKEQ---KELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
                E+  KE+ +Q +   +N L+ Q    +L+  ++  K  + + + + N+   +  + 
Sbjct: 1844 AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903

Query: 944  QNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
            Q+ L++  +     +  +N+L+  S     Q
Sbjct: 1904 QHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934



 Score =  133 bits (335), Expect = 1e-30
 Identities = 161/716 (22%), Positives = 315/716 (43%), Gaps = 75/716 (10%)

Query: 650  LLLSAEAAK--TAQRADLQN------HLDTAQNALQDKQ----QELNKITTQLDQVTAKL 697
            LL SAEA K     + D +         +  +  L++K     QE N +  Q+   T  L
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902

Query: 698  QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR 757
             D +E C  L       K K L LE K +EL  ++++ E  + E+ A K          +
Sbjct: 903  MDAEERCEGL------IKSKIL-LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955

Query: 758  QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817
            +   DLEL  T++ K    EK    +   +L ++  ALE    KLTK   EK+ L++  +
Sbjct: 956  RDIDDLELTLTKVEK----EKHATENKVKNLSEEMTALEENISKLTK---EKKSLQEAHQ 1008

Query: 818  TLSQETKIQHEELNN------RIQTTVTELQKVKMEKEALMTELSTVKDKLS---KVSDS 868
                + +++ +++N       +++    +L+    +++ L  +L   K KL    K+S  
Sbjct: 1009 QTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068

Query: 869  ----LKNSKSEFEKENQKGKAAILDLE-KTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
                L+N K + E++ +K +  +  L+ K   E  H LQ Q +  +KE +   + LE+E 
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK--IKELQARIEELEEEI 1126

Query: 924  EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
            EA H L+ ++   +  L +    L++  +  ++  G  +   + +++++ + + ++ +L+
Sbjct: 1127 EAEHTLRAKIEKQRSDLARE---LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183

Query: 984  IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
             A LQ       L+++   +  EL    E+I  LQ   +K ++   +L+ +     S + 
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELG---EQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240

Query: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
            A  +   ++E      ++     + +   Q +LI +L   KA L+  + +   +++E+  
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300

Query: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-K 1162
             +  + K K    ++L          EE+K RQ +E TK    + +H L+S +   +L +
Sbjct: 1301 LISQLTKSKQALTQQL----------EELK-RQMEEETKAKNAM-AHALQSSRHDCDLLR 1348

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
            +  +   + K ELQ       + V Q +   +    Q  +E EE KK       KL   +
Sbjct: 1349 EQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK-------KLAQRL 1401

Query: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
            +E E   +      A L      L   +  + ++ + S    + L+K+  +    +A  +
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461

Query: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
              +    DE +A LE   K   E   L T++ +++   +     ++ L REN++LQ
Sbjct: 1462 QKL----DESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQ 1510



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 108/538 (20%), Positives = 232/538 (43%), Gaps = 71/538 (13%)

Query: 910  KEQKELKKSLEKEKEA---SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
            KE   +K+  E+ KE    S   + EL      L+Q +N L+   + E +   N+ + ++
Sbjct: 851  KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE---NLMDAEE 907

Query: 967  SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
              E   K    L+ ++K  + ++ E E ++  +L    + L   ++K S L+ + +  + 
Sbjct: 908  RCEGLIKSKILLEAKVK-ELTERLEEEEEMNSELVAKKRNL---EDKCSSLKRDIDDLEL 963

Query: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLS-------LAQEDLISNRNQIGNQNKLIQE 1079
            T  +++ + +  E+++    +++ ++EE +S         QE      + +  +   +  
Sbjct: 964  TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023

Query: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
            L    A LEQ +   E  L++  K   D+++ K   E +L   +  + ++E  K + E++
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083

Query: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQILKD 1198
            + K     K  +L  ++   + +    L  Q+K+ ELQ + + L+  +E E      L+ 
Sbjct: 1084 LKK-----KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE----HTLRA 1134

Query: 1199 QVKKEEEELKKEFIE---------------------KEAKLHSEIKEKEVGMKKHEENEA 1237
            +++K+  +L +E  E                     +EA+     ++ E    +HE   A
Sbjct: 1135 KIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 1238 KLTMQ----ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
             L  +    +  L E +  +++  Q  ++  SEL+ + DD+   I  L  +  N +   R
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254

Query: 1294 ALLERC--LKGEGEIE------------KLQTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
             + ++   +K + E +            +LQT+  EL  +++   + + +L +  Q+L  
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL-T 1313

Query: 1340 KHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKK 1397
            +  + L R+  E+ + +N MA     ++   RH C      +  E  AK  L  +  K
Sbjct: 1314 QQLEELKRQMEEETKAKNAMA----HALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  223 bits (569), Expect = 8e-58
 Identities = 258/1194 (21%), Positives = 537/1194 (44%), Gaps = 119/1194 (9%)

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
            L+ A+TE   +  MK+ FE+   +LA    + K K  EE+ +    E+   +L  +   +
Sbjct: 844  LKSAETEK-EMANMKEEFEKTKEELAK--TEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 204  ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
            A    + + + L +  I+  A +K E+ +     + +  E   +  KL+DEC +L+    
Sbjct: 901  ALADAEERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959

Query: 264  SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
              E T++++  E      +V    +E+  L  ++ +LT++ + L E   +   D    E+
Sbjct: 960  DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEED 1019

Query: 324  KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
            K N  + +K  ++  +   +   +Q +      E +  ++  +L    E+T   + +  +
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079

Query: 384  VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL-GEAHGRLKEQRQ 442
            +  K +  + E   LQ + E+++   +QLQ +I +L +++ E E ++  E   R K ++Q
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139

Query: 443  LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
             S     D  +++ ++  +L         ++  + + + +  K ++  +E     ++T A
Sbjct: 1140 RS-----DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAA 1194

Query: 503  KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
             LR+   D       + +  ++I +L+ + QK ++  S L+ E  DL + ++      A 
Sbjct: 1195 ALRKKHAD------SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKA- 1247

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
                ++   TL++Q++++  K        ++ Q+ L +++  QKA           L T 
Sbjct: 1248 --NFEKMCRTLEDQLSEIKTK--------EEEQQRLINELSAQKAR----------LHTE 1287

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
              E + QL+E    VSQL    +A T+ +   +     Q  +      T  +ALQ  + +
Sbjct: 1288 SGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK----RQLEEETKAKSTLAHALQSARHD 1343

Query: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLE 741
             + +  Q ++      + Q   S+  S + +++ KY     Q+TEELE   KKL      
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL------ 1397

Query: 742  VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
                  Q LQD ++  +    +  +   L K  +  +  V    +D+++ + A  ++ +K
Sbjct: 1398 -----AQRLQDAEEHVEA---VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKK 1449

Query: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
                ++     KQ +E    ET+ + E      ++  TEL KVK   E  +  L T+K  
Sbjct: 1450 QRNFDKVLAEWKQKYE----ETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK-- 1503

Query: 862  LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
              + + +L+   S+  ++  +G   I +LEK  K+L H+ + +++ +L   +E + SLE 
Sbjct: 1504 --RENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE-KSELQTSL---EEAEASLEH 1557

Query: 922  EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK-KKQIEALQG 980
            E+    +++LELN ++ ++      + + ++E  QL+ N   + +S +     +I +   
Sbjct: 1558 EEGKILRIQLELNQVKSEI---DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRND 1614

Query: 981  ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
             L+I    + +L N+++ QL  A ++ A   E +  L+N     ++T   L     G++ 
Sbjct: 1615 ALRIKKKMEGDL-NEMEIQLNHANRQAA---EALRNLRNTQGILKDTQLHLDDAIRGQDD 1670

Query: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
                 ++ L  VE + +L Q +              ++EL+ +    E+     EQ+L +
Sbjct: 1671 ----LKEQLAMVERRANLMQAE--------------VEELRASLERTERGRKMAEQELLD 1712

Query: 1101 RCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159
              + +Q +  + +     L+N K KL  +I +I    + E+  + +E ++ + ++ K IT
Sbjct: 1713 ASERVQLLHTQNT----SLINTKKKLETDISQI----QGEMEDIVQEARNAEEKAKKAIT 1764

Query: 1160 NLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV--------KKEEEELKK 1209
               DA  +  + K E    A  + +K  +EQ  ++ Q+  D+         KK+ ++L+ 
Sbjct: 1765 ---DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1821

Query: 1210 EFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
               E E+++ SE K   E   G++KHE    +LT Q     +N+  ++      Q +V  
Sbjct: 1822 RVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKA 1881

Query: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
             ++Q ++   +  V  A  +  Q E     ER    E ++ KL+ K  E+  K+
Sbjct: 1882 YKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKV 1935



 Score =  192 bits (488), Expect = 2e-48
 Identities = 250/1181 (21%), Positives = 509/1181 (43%), Gaps = 159/1181 (13%)

Query: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASET 358
            +L  + Q +    L + + + K+ E+       + NI+A ++ K     +L  ++     
Sbjct: 787  QLITRTQAICRGFLMRVE-FRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLK 845

Query: 359  SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN- 417
            S      E++   E  +K KEEL++ E K + L+ +   L Q++ + +   LQ+Q+E + 
Sbjct: 846  SAET-EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ---LQVQAEADA 901

Query: 418  ---------QLHSKLLETERQLGEAHGRLKEQRQLSSE------KLMDK----EQQVADL 458
                     QL    ++ E ++ E   R +++ ++++E      KL D+    ++ + DL
Sbjct: 902  LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961

Query: 459  QLKLSRLEEQ---LKEKVTNSTELQHQLDKT-----KQQHQEQQALQQS----------- 499
            +L L+++E++    + KV N TE    LD+T     K++   Q+A QQ+           
Sbjct: 962  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021

Query: 500  -----TTAKLREAQNDLEQVLRQ----IGDKDQKIQNLEALLQKSKENISLLEKEREDLY 550
                    KL +  +DLE  L Q      D ++  + LE  L+ ++E+    E +++ L 
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN 1081

Query: 551  AKIQAGE-----------GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599
             K++  E            E A+  QLQ+K   LQ ++ +L E+++ +  S  +A++   
Sbjct: 1082 EKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1141

Query: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
            D  +E    L    +R   LE +    ++Q+  +K++ ++     +   E  L  EA   
Sbjct: 1142 DLSRE----LEEISER---LEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAA 1194

Query: 660  AQR-------ADLQNHLDTAQNALQ-------DKQQELNKITTQLDQVTAKLQDKQEHCS 705
            A R       A+L   +D+ Q   Q       + + E+N + + ++ V+    + ++ C 
Sbjct: 1195 ALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254

Query: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS---KEQALQDLQQQRQLNTD 762
             LE  L E K K    ++   EL  Q  +L  +S E       K+  +  L + +Q  T 
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314

Query: 763  LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
               +  EL +QLE E +  S+    LQ      + ++++  +++E K  L++     + E
Sbjct: 1315 ---QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371

Query: 823  -----TKIQH------EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN 871
                 TK +       EEL    +     LQ  +   EA+ ++ ++    L K    L+N
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS----LEKTKQRLQN 1427

Query: 872  SKSEFEKENQKGKAAILDLEKT----------CKELKHQLQVQMENTLKEQKELKKSLEK 921
               +   + ++  AA + L+K            K+   + Q ++E + KE + L   L K
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487

Query: 922  EKEASHQ--------------LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
             K A  +              L+ E++ + EQ+ +    + + EK ++QL    +EL+ S
Sbjct: 1488 VKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTS 1547

Query: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
             E+ +  +E  +G++         ++ +L Q  ++  +++A + E++  L+ N+ +  E+
Sbjct: 1548 LEEAEASLEHEEGKI-------LRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600

Query: 1028 FKQ-LQSDFYGRESELLATRQ---DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE--LK 1081
             +  L ++   R   L   ++   DL  +E +L+ A          + N   ++++  L 
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660

Query: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
               A   QD  K++  + ER   L   + E+     E      K+AE E +   +  ++ 
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720

Query: 1142 KL-NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
               N  L + K +   +I+ ++   + ++Q+    + KA   KA  +     +++ K+Q 
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAK--KAITDAAMMAEELKKEQD 1778

Query: 1201 KKEEEELKKEFIEKEAK-LHSEIKEKE-VGMKKHEENEAKLTMQITALNENLGTVKKE-- 1256
                 E  K+ +E+  K L   + E E + +K  ++   KL  ++  L   + + +K   
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNV 1838

Query: 1257 -----WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1311
                  +  +RRV EL  QT++ R  I  L+  V   Q + +A   +  + E +      
Sbjct: 1839 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA 1898

Query: 1312 KVLELQRKLDNTTAAVQELGRENQSLQIK----HTQALNRK 1348
            K  +LQ +L+           +   L++K    HT+ ++ +
Sbjct: 1899 KFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939



 Score =  179 bits (455), Expect = 1e-44
 Identities = 212/1009 (21%), Positives = 447/1009 (44%), Gaps = 140/1009 (13%)

Query: 86   TLLRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKPDGLVTDSSAELQSLEQ 142
            T L Q+V DL+ SL++EK    +L++   K +G   L Q+         D+  + Q L +
Sbjct: 1029 TKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES------TMDTENDKQQLNE 1082

Query: 143  QLEEAQTENFNIK-QMKD------LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
            +L++ + E  N++ +++D        ++K  +L   I +++ + + ER+ R  AE++ + 
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142

Query: 196  LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
            L+ EL                    E+++   +E     +    M  +RE E +K++   
Sbjct: 1143 LSREL--------------------EEISERLEEAGGATSAQIEMNKKREAEFQKMR--- 1179

Query: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
            + L+      EAT + LR + A    E+   +  LQ++K                  K E
Sbjct: 1180 RDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQ-----------------KLE 1222

Query: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375
            ++ ++L+ + N+ + + + +       +  C+ L+ +LS           E+  K E  Q
Sbjct: 1223 KEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS-----------EIKTKEEEQQ 1271

Query: 376  KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
            +L  ELS  + +   L  E  +  +Q +EK+    QL         ++ E +RQL E   
Sbjct: 1272 RLINELSAQKAR---LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE--- 1325

Query: 436  RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ------ 489
              + + + +    +   +   DL      L EQ +E+     ELQ  + K   +      
Sbjct: 1326 --ETKAKSTLAHALQSARHDCDL------LREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377

Query: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
              E  A+Q+  T +L EA+  L Q L+   +  + + +  A L+K+K+    L+ E EDL
Sbjct: 1378 KYETDAIQR--TEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR---LQNEVEDL 1432

Query: 550  YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV------- 602
               ++        L++ Q     +  +  Q  E+ + + E+ ++   +L  ++       
Sbjct: 1433 MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAY 1492

Query: 603  QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
            +E   HL   +    +L+  +++L  Q+ E  + + +L+   K K +L          ++
Sbjct: 1493 EESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE---KVKKQL--------DHEK 1541

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS-L 721
            ++LQ  L+ A+ +L+ ++ ++ +I  +L+QV +++  K    ++ +  L + K  +L  +
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK---IAEKDEELDQLKRNHLRVV 1598

Query: 722  EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
            E     L+ +I+    D+L +K   E  L ++  + QLN     +A E  + L   + I+
Sbjct: 1599 ESMQSTLDAEIRS-RNDALRIKKKMEGDLNEM--EIQLN-HANRQAAEALRNLRNTQGIL 1654

Query: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL-------SQETKIQHEEL---N 831
              T+L L       + +K++L   E    +++ + E L        +  K+  +EL   +
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDAS 1714

Query: 832  NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE 891
             R+Q   T+   +   K+ L T++S ++ ++  +    +N++       +K K AI D  
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE-------EKAKKAITDAA 1767

Query: 892  KTCKELKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ 949
               +ELK +      +E   K  ++  K L+   + + QL L+    Q Q ++A+    +
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827

Query: 950  NEKEEQQLQGNINELK--QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
            +E E +Q + N+  +K  +  E++ K++     E +  +L+  +L +KLQ ++    ++ 
Sbjct: 1828 SEVESEQ-KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886

Query: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
               +E+ +V    + K Q   ++ +      ES++   R   + V  K+
Sbjct: 1887 EEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKV 1935



 Score =  111 bits (277), Expect = 6e-24
 Identities = 125/566 (22%), Positives = 246/566 (43%), Gaps = 69/566 (12%)

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL------KHQLQVQMENTLKEQKELKK 917
            K+   LK++++E E  N K      + EKT +EL      + +L+ +M   ++E+ +L+ 
Sbjct: 839  KIKPLLKSAETEKEMANMKE-----EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893

Query: 918  SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQK--- 971
             ++ E +A    +   + + +  IQ +  +K+     ++E+++   +   K+  E +   
Sbjct: 894  QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953

Query: 972  -KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
             KK I+ L+  L     +K   ENK++       +E+A   E I+ L    +  QE  +Q
Sbjct: 954  LKKDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
               D    E ++      L   + KL    +DL  +  Q   + KL  +L+ AK  LE D
Sbjct: 1010 TLDDLQMEEDKV----NTLTKAKTKLEQQVDDLEGSLEQ---EKKLCMDLERAKRKLEGD 1062

Query: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN------ 1144
                ++   +     Q + ++   KE E+ N + K+ + + +  + +K+I +L       
Sbjct: 1063 LKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL 1122

Query: 1145 -EELKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
             EE+++ +    K      D  + L  I ++LE  G A S  A +E  K+ +   +   +
Sbjct: 1123 EEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS--AQIEMNKKREAEFQKMRR 1180

Query: 1202 KEEEE----------LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251
              EE           L+K+  +  A+L  +I   +   +K E+ +++L M+I  L  N+ 
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME 1240

Query: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1311
            TV K   + ++    LE Q  +           ++  ++E++ L+        +  +L T
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSE-----------IKTKEEEQQRLINEL---SAQKARLHT 1286

Query: 1312 KVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRR 1371
            +  E  R+LD   A V +L R  Q+   +  + L R+  E+ + ++ +A     ++   R
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAF-TQQIEELKRQLEEETKAKSTLA----HALQSAR 1341

Query: 1372 HHCRQCGNIFCAECSAKNALTPSSKK 1397
            H C      +  E  AK  L     K
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSK 1367



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 74/305 (24%), Positives = 134/305 (43%), Gaps = 56/305 (18%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            +  LA+      L++ EV++L+ASL           +  E+ + + +QE      + D+S
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASL-----------ERTERGRKMAEQE------LLDAS 1714

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
              +Q L        T+N ++   K   E   +Q+  E+ DI     E R+  E A++ +T
Sbjct: 1715 ERVQLL-------HTQNTSLINTKKKLETDISQIQGEMEDI---VQEARNAEEKAKKAIT 1764

Query: 195  ---RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
                + EEL KE    QD    L +         +KK +   QT+ D      E E   L
Sbjct: 1765 DAAMMAEELKKE----QDTSAHLER---------MKKNM--EQTVKDLQLRLDEAEQLAL 1809

Query: 252  KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT------QKNQ 305
            K   K++Q      EA + +L SE+    +     V+ L+K +  V ELT      +KN 
Sbjct: 1810 KGGKKQIQ----KLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI 1865

Query: 306  TLTENLLKKEQDYTKLEEKHNEESVSKKNIQ-ATLHQKDLDCQQLQSRLSASETSLHRIH 364
               ++L+ K Q   K  ++  EE+  + N+  A   +   + ++ + R   +E+ ++++ 
Sbjct: 1866 LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLR 1925

Query: 365  VELSE 369
            V+  E
Sbjct: 1926 VKSRE 1930


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  222 bits (565), Expect = 2e-57
 Identities = 257/1199 (21%), Positives = 535/1199 (44%), Gaps = 129/1199 (10%)

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
            L+ A+TE   +  MK+ FE+   +LA    + K K  EE+ +    E+   +L  +   +
Sbjct: 844  LKSAETEK-EMANMKEEFEKTKEELAK--TEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 204  ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
            +    + + + L +  I+  A +K E+ +     + +  E   +  KL+DEC +L+    
Sbjct: 901  SLADAEERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959

Query: 264  SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
              E T++++  E      +V    +E+  L  ++ +LT++ + L E   +   D    E+
Sbjct: 960  DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019

Query: 324  KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
            K N  + +K  ++  +   +   +Q +      E +  ++  +L    E+T  ++ +  +
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079

Query: 384  VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL-GEAHGRLKEQRQ 442
            ++ K +  + E   LQ + E+++  G+QLQ +I +L +++ E E ++  E   R K ++Q
Sbjct: 1080 LDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139

Query: 443  LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
             S     D  +++ ++  +L         ++  + + + +  K ++  +E     ++T A
Sbjct: 1140 RS-----DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 503  KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
             LR+   D       + +  ++I NL+ + QK ++  S ++ E +DL + +   E  +  
Sbjct: 1195 TLRKKHAD------SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM---ETVSKA 1245

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
               L++    L++Q++++  K        ++ Q+ L + +  Q+A L+            
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTK--------EEEQQRLINDLTAQRARLQTESGEYSRQLDE 1297

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
             + L SQL+  K+  +Q   ++K + E  + A++A                +ALQ  + +
Sbjct: 1298 KDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSA--------------LAHALQSSRHD 1343

Query: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLE 741
             + +  Q ++      + Q   S+  S + +++ KY     Q+TEELE   KKL      
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL------ 1397

Query: 742  VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
                  Q LQD ++  +    +  +   L K  +  +  V    +D+++ + A  ++ + 
Sbjct: 1398 -----AQRLQDAEEHVEA---VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK- 1448

Query: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
              KQ    +IL  +++   +ET  + E      ++  TEL K+K   E  + +L T+K  
Sbjct: 1449 --KQRNFDKIL-AEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK-- 1503

Query: 862  LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQMENTLKEQKELKKS 918
              + + +L+   S+  ++  +G   I +LEK  K++   K +LQ  +E       E + S
Sbjct: 1504 --RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE-------EAEAS 1554

Query: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
            LE E+    +++LELN ++ ++ +     K  EK+E        E+ Q      + +E++
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDR-----KIAEKDE--------EIDQMKRNHIRIVESM 1601

Query: 979  QGELKIAVLQKTE---LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
            Q  L   +  + +   L+ K++  L +   +L       +    NY  +Q   K  Q   
Sbjct: 1602 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL 1661

Query: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
                 + L +++DLK   E+L++ +             N L  E++  +ATLEQ    ++
Sbjct: 1662 ----DDALRSQEDLK---EQLAMVER----------RANLLQAEIEELRATLEQTERSRK 1704

Query: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKLES 1154
               QE   A + +Q   + +   L+N K KL  +I +I    + E+  + +E ++ + ++
Sbjct: 1705 IAEQELLDASERVQLLHT-QNTSLINTKKKLETDISQI----QGEMEDIIQEARNAEEKA 1759

Query: 1155 IKEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV--------KKEE 1204
             K IT   DA  +  + K E    A  + +K  +EQ  ++ Q   D+         KK+ 
Sbjct: 1760 KKAIT---DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816

Query: 1205 EELKKEFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261
            ++L+    E E ++ SE K   E   G++KHE    +LT Q     +N+  ++      Q
Sbjct: 1817 QKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQ 1876

Query: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
             +V   ++Q ++   +  V  +  +  Q E     ER    E ++ KL+ K  E+  K+
Sbjct: 1877 AKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935



 Score =  176 bits (446), Expect = 1e-43
 Identities = 202/1003 (20%), Positives = 440/1003 (43%), Gaps = 145/1003 (14%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQG-----------LQQQEAKPDGLVTDSSAE 136
            L Q+V DL+ SL++EK    +L++   K +G           ++  + + D  +     E
Sbjct: 1031 LEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFE 1090

Query: 137  LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
            +  L+ ++E+ Q     +       ++K  +L   I +++ + + ER+ R  AE++ + L
Sbjct: 1091 MSGLQSKIEDEQALGMQL-------QKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1143

Query: 197  TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
            + EL                    E+++   +E     +    M  +RE E +K++ + +
Sbjct: 1144 SREL--------------------EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183

Query: 257  KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
            +   Q+   EAT + LR + A    E+   +  LQ++K                 L+KE+
Sbjct: 1184 EATLQH---EATAATLRKKHADSVAELGEQIDNLQRVKQK---------------LEKEK 1225

Query: 317  DYTKLE---EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
               K+E      N E+VSK   +  L +    C+ L+ +LS           E+  K E 
Sbjct: 1226 SEMKMEIDDLASNMETVSK--AKGNLEKM---CRALEDQLS-----------EIKTKEEE 1269

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
             Q+L   ++++  +   L+ E  +  +Q +EK+    QL         ++ E +RQL E 
Sbjct: 1270 QQRL---INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE- 1325

Query: 434  HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ---- 489
               +K +  L+    +   +   DL      L EQ +E+     ELQ  + K   +    
Sbjct: 1326 --EIKAKSALA--HALQSSRHDCDL------LREQYEEEQEAKAELQRAMSKANSEVAQW 1375

Query: 490  --HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
                E  A+Q+  T +L EA+  L Q L+   +  + +    A L+K+K+    L+ E E
Sbjct: 1376 RTKYETDAIQR--TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQR---LQNEVE 1430

Query: 548  DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV----- 602
            DL   ++      A L++ Q     +  +  Q  E+   + E+ ++   +L  ++     
Sbjct: 1431 DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKN 1490

Query: 603  --QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
              +E    L   +    +L+  +++L  Q+ E  +++ +L+ +IK + E           
Sbjct: 1491 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVE----------Q 1539

Query: 661  QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA----KLQDKQEHCSQLE-SHLKEYK 715
            ++++LQ  L+ A+ +L+ ++ ++ +I  +L+QV +    K+ +K E   Q++ +H++  +
Sbjct: 1540 EKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVE 1599

Query: 716  EKYLSLEQK----------TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
                +L+ +           +++EG + ++E           +AL++ +  + +  D +L
Sbjct: 1600 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659

Query: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
               +  +  E  KE ++            +E ++  L + E  ++I +Q+    S+  ++
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1719

Query: 826  QHEELNNRIQT---TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
             H +  + I T     T++ +++ E E ++ E    ++K  K          E +KE   
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779

Query: 883  G---KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
                +    +LE+T K+L+H+L    +  LK     KK ++K +    +L+ E+ S Q++
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG---KKQIQKLEARVRELEGEVESEQKR 1836

Query: 940  LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
             ++A   L+++E++ ++L     E +++  + +  ++ LQ ++K    Q  E E +    
Sbjct: 1837 NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVN 1896

Query: 1000 LT---QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
            L+   +   EL   +E+  + ++   K +   +++ +     E
Sbjct: 1897 LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939



 Score =  164 bits (416), Expect = 4e-40
 Identities = 197/935 (21%), Positives = 406/935 (43%), Gaps = 104/935 (11%)

Query: 84   DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
            D+ L ++   D++    +++   E+LKK+  +  GLQ +      L      +++ L+ +
Sbjct: 1062 DLKLAQESTMDIE---NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQAR 1118

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE----------RSLREAAEQKV 193
            +EE + E    +  +   E++ + L+ E+ +I  + +E              REA  QK+
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1178

Query: 194  TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
             R  E    EAT+  +     L++   + VA L +++  +Q +        +++ EK K 
Sbjct: 1179 RRDLE----EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKS 1226

Query: 254  ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
            E K      AS+  T+S+ +  L K         + L+   S +    ++ Q L  +L  
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEK-------MCRALEDQLSEIKTKEEEQQRLINDLTA 1279

Query: 314  KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
            +     +L+ +  E S         L +KD    QL     A    +  +  +L E+ +A
Sbjct: 1280 QR---ARLQTESGEYS-------RQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKA 1329

Query: 374  TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
               L   L         L+ ++++ Q+ + E ++   +  SE+ Q  +K      Q  E 
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE- 1388

Query: 434  HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE-LQHQLDKTKQQHQE 492
               L+E ++  +++L D E+ V  +  K + L E+ K+++ N  E L   +++T      
Sbjct: 1389 --ELEEAKKKLAQRLQDAEEHVEAVNAKCASL-EKTKQRLQNEVEDLMIDVERT------ 1439

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
                  +  A L + Q + +++L    +  QK +   A L+ S++    L  E   L+  
Sbjct: 1440 -----NAACAALDKKQRNFDKIL---AEWKQKCEETHAELEASQKESRSLSTE---LFKI 1488

Query: 553  IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
              A E     L  L+ +N  LQ++++ LTE++    +   +  E +  QV+++K+ L+AA
Sbjct: 1489 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL-EKIKKQVEQEKSELQAA 1547

Query: 613  -----------QDRVLSLETSVNELNSQLN----ESKEKVSQL---DIQIKAKTELLLSA 654
                       + ++L ++  +N++ S+++    E  E++ Q+    I+I    +  L A
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ----LDQVTAKLQDKQEHCSQLESH 710
            E         L+  ++   N ++ +    N++  +         A L+D Q H       
Sbjct: 1608 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRS 1667

Query: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK---EQALQDLQQQRQLNTDLELRA 767
             ++ KE+   +E++   L+ +I++L A   + + S+   EQ L D  ++ QL        
Sbjct: 1668 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1727

Query: 768  TELSKQLEMEKEIVSSTRLD-LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
                K+LE +   +     D +Q+   A E  K+ +T      + LK++     Q+T   
Sbjct: 1728 INTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE-----QDTSAH 1782

Query: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
             E +   ++ TV +LQ    E E L   L   K ++ K+   ++  + E E E ++   A
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVESEQKRNVEA 1840

Query: 887  ILDL---EKTCKELKHQLQVQMENTLKEQ---KELKKSLEKEKEASHQLKLELNSMQEQL 940
            +  L   E+  KEL +Q +   +N L+ Q    +L+  ++  K  + + + + N    + 
Sbjct: 1841 VKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKF 1900

Query: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
             + Q+ L++ E+     +  +N+L+  S +   +I
Sbjct: 1901 RRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935



 Score =  125 bits (314), Expect = 3e-28
 Identities = 151/737 (20%), Positives = 316/737 (42%), Gaps = 94/737 (12%)

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
            E  +  +  +  ++KE++++ + + K   E +++    K     DLQ  +    ++L D 
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN----DLQLQVQAEADSLADA 905

Query: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
            ++  +++     Q+ AK+++  E     E    E   K   LE +  EL+  I  LE   
Sbjct: 906  EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965

Query: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
             +V+  K      ++   +    L+    +L+K+ +  +E    T  DLQ + + + ++ 
Sbjct: 966  AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025

Query: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
            +   K E++   L+   E   QE KI+ +           E  K K+E +  + + ST+ 
Sbjct: 1026 KAKIKLEQQVDDLEGSLE---QEKKIRMD----------LERAKRKLEGDLKLAQESTMD 1072

Query: 860  DKLSKVSDSLKNSKSEFEKENQKGK-----AAILDLEKTCKELKHQLQVQMENTLKEQKE 914
             +  K     K  K EFE    + K     A  + L+K  KEL+ +++ ++E  ++ ++ 
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIE-ELEEEIEAERA 1131

Query: 915  LKKSLEKEKEASHQLKLELNSMQEQLIQAQNT----LKQNEKEEQQLQGNINELKQSSEQ 970
             +   EK++     L  EL  + E+L +A       ++ N+K E + Q    +L++++ Q
Sbjct: 1132 SRAKAEKQRS---DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 971  KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
             +     L+ +   +V +  E  + LQ+      Q+L  EK ++ +  ++   + ET  +
Sbjct: 1189 HEATAATLRKKHADSVAELGEQIDNLQR----VKQKLEKEKSEMKMEIDDLASNMETVSK 1244

Query: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQELKTAKATLEQ 1089
             + +                   EK+  A ED +S  + +   Q +LI +L   +A L+ 
Sbjct: 1245 AKGNL------------------EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQT 1286

Query: 1090 DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1149
            +S +  +QL E+   +  + + K          ++   +IEE+K + E+EI    +   +
Sbjct: 1287 ESGEYSRQLDEKDTLVSQLSRGK----------QAFTQQIEELKRQLEEEIKA--KSALA 1334

Query: 1150 HKLESIKEITNL-KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK 1208
            H L+S +   +L ++  +   + K ELQ       + V Q +   +    Q  +E EE K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 1209 KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
            K+  ++              ++  EE+       + A+N    +++K  Q  Q  V +L 
Sbjct: 1395 KKLAQR--------------LQDAEEH-------VEAVNAKCASLEKTKQRLQNEVEDLM 1433

Query: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE-------KLQTKVLELQRKLD 1321
               +      A L+   +N         ++C +   E+E        L T++ +++   +
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYE 1493

Query: 1322 NTTAAVQELGRENQSLQ 1338
             +   ++ L REN++LQ
Sbjct: 1494 ESLDQLETLKRENKNLQ 1510



 Score =  104 bits (260), Expect = 5e-22
 Identities = 121/563 (21%), Positives = 246/563 (43%), Gaps = 63/563 (11%)

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
            K+   LK++++E E  N K      + EKT +EL          T  ++KEL++ +    
Sbjct: 839  KIKPLLKSAETEKEMANMKE-----EFEKTKEELA--------KTEAKRKELEEKMVTLM 885

Query: 924  EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
            +  + L+L++ +  + L  A+    Q  K + QL+  I E+ + +E +++    L  + +
Sbjct: 886  QEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 945

Query: 984  IAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
                + +EL+   + L+  L +  +E  A + K+  L        ET  +L  +    + 
Sbjct: 946  KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005

Query: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
                T  DL++ E+K++   +  I    Q+ +    +++ K  +  LE+   K E  L+ 
Sbjct: 1006 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065

Query: 1101 RCKALQDIQKEKSL-------KEKELVNEKSKLAEIEEIKCRQEKEITKLN-------EE 1146
              ++  DI+ +K         KE E+   +SK+ + + +  + +K+I +L        EE
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125

Query: 1147 LKSHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
            +++ +    K      D  + L  I ++LE  G A S  A +E  K+ +   +   +  E
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS--AQIEMNKKREAEFQKMRRDLE 1183

Query: 1205 EE----------LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
            E           L+K+  +  A+L  +I   +   +K E+ ++++ M+I  L  N+ TV 
Sbjct: 1184 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243

Query: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314
            K   + ++    LE Q  +           ++  ++E++ L+        +  +LQT+  
Sbjct: 1244 KAKGNLEKMCRALEDQLSE-----------IKTKEEEQQRLINDL---TAQRARLQTESG 1289

Query: 1315 ELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHC 1374
            E  R+LD     V +L R  Q+   +  + L R+  E+ + ++ +A     ++   RH C
Sbjct: 1290 EYSRQLDEKDTLVSQLSRGKQAF-TQQIEELKRQLEEEIKAKSALA----HALQSSRHDC 1344

Query: 1375 RQCGNIFCAECSAKNALTPSSKK 1397
                  +  E  AK  L  +  K
Sbjct: 1345 DLLREQYEEEQEAKAELQRAMSK 1367



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 142/749 (18%), Positives = 301/749 (40%), Gaps = 133/749 (17%)

Query: 2    LRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYE 61
            L+R+ Q+          ++D  A+ + TV     S ++G +   C        E+    E
Sbjct: 1214 LQRVKQKLEKEKSEMKMEIDDLASNMETV-----SKAKGNLEKMCRALEDQLSEIKTKEE 1268

Query: 62   AVHDAGND--------SGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL 113
                  ND            GE +  L   D TL+ Q  +  QA  ++ +    +L++E+
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKD-TLVSQLSRGKQAFTQQIEELKRQLEEEI 1327

Query: 114  EKYQGLQQ--QEAKPD-GLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLA 169
            +    L    Q ++ D  L+ +   E Q  + +L+ A ++ N  + Q +  +E  A Q  
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387

Query: 170  TEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKE 229
             E+ + K K  +   L++A E       E +N +   ++  K  L     +ED+ +  + 
Sbjct: 1388 EELEEAKKKLAQR--LQDAEEH-----VEAVNAKCASLEKTKQRLQNE--VEDLMIDVER 1438

Query: 230  LVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE 289
                   +D      ++   + K +C++  ++  +S+     L +EL K        + +
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498

Query: 290  LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
            L+ LK     L Q+   LTE + +  +   +LE+   +    K  +QA L + +   +  
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHE 1558

Query: 350  QSRLSASETSLHRI---------------------HVELSEKGEAT-------------- 374
            + ++   +  L+++                     H+ + E  ++T              
Sbjct: 1559 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618

Query: 375  -QKLKEELSEVETK--------------YQHLKAEFKQ--------LQQQREEKEQHGLQ 411
             +K++ +L+E+E +              Y++ +A  K         L+ Q + KEQ  + 
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678

Query: 412  ------LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
                  LQ+EI +L + L +TER            R+++ ++L+D  ++V  L  + + L
Sbjct: 1679 ERRANLLQAEIEELRATLEQTERS-----------RKIAEQELLDASERVQLLHTQNTSL 1727

Query: 466  EEQLKEKVTNSTELQHQLDKTKQQHQ-----------------EQQALQQSTTAKLREAQ 508
                K+  T+ +++Q +++   Q+ +                 E+   +Q T+A L   +
Sbjct: 1728 INTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1787

Query: 509  NDLEQVLRQI-------------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
             +LEQ ++ +             G K Q IQ LEA +++ +  +   +K   +    ++ 
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQ-IQKLEARVRELEGEVESEQKRNVEAVKGLRK 1846

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             E +   L    E++     ++  L +KL+ + +S+K+  E   +Q     +  R  Q  
Sbjct: 1847 HERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE 1906

Query: 616  VLSLETSVNELNSQLNESKEKVSQLDIQI 644
            +   E   +   SQ+N+ + K  ++  +I
Sbjct: 1907 LEEAEERADIAESQVNKLRVKSREVHTKI 1935


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  221 bits (563), Expect = 4e-57
 Identities = 314/1442 (21%), Positives = 668/1442 (46%), Gaps = 219/1442 (15%)

Query: 86   TLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLE 145
            T L +E+++L++    E    + +K   E+   L  ++A+ +        E   ++Q++E
Sbjct: 49   TELEKEIEELRSKPVTEGT-GDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVE 107

Query: 146  EAQTE----NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS-----LREAAEQKVTRL 196
            ++ T+    +  ++Q    + ++   L  E+  ++SKY E+++     L EA   ++  L
Sbjct: 108  DSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQL-EL 166

Query: 197  TEEL---NKEATVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
            +E+L   N     ++ L+ E+ + RPG E+      +++ +Q  +D  T E++    +L+
Sbjct: 167  SEQLKFQNNSEDNVKKLQEEIEKIRPGFEE------QILYLQKQLDATTDEKKETVTQLQ 220

Query: 253  DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT------ 306
            +  +     Y   +  I+ L+ EL    Q  A++ +E+++L   +    ++++       
Sbjct: 221  NIIEANSQHY---QKNINSLQEELL---QLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274

Query: 307  -LTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLHRI 363
             L ENL+K+ E     +++K+  E  + +   +  +Q +  C   LQ      +    ++
Sbjct: 275  ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334

Query: 364  -HVE--LSEKGEATQKLKEELS-------EVETKYQHLKAEFKQLQQQRE--------EK 405
             H+E  L E       LK+E++       ++E   QH+K EF   ++  E         K
Sbjct: 335  KHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK 394

Query: 406  EQHGL---QLQSEINQLHSKLLETERQLGEAHGRLKEQRQ-----LSSEKLMDKEQQVAD 457
            E+ G    +L+SE+  L+ +   T  Q       LKEQ Q     L+   L D E++   
Sbjct: 395  EEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT 454

Query: 458  LQLKLSRLEEQL-------KEKVTN-----------STELQHQLDKTKQQHQ---EQQA- 495
            L  ++  L+EQ        +E + N            TEL     K  Q+ +   +QQA 
Sbjct: 455  LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQAS 514

Query: 496  ----LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA 551
                LQQ       E    LE V R  G+ ++K+ + + L+ + +  I  L+ E+  +Y 
Sbjct: 515  DVHELQQKLRTAFTEKDALLETVNRLQGE-NEKLLSQQELVPELENTIKNLQ-EKNGVYL 572

Query: 552  KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA 611
             +   + +T +L +L+ K ++L E+      KLKN  E      +N H + + ++  +  
Sbjct: 573  -LSLSQRDT-MLKELEGKINSLTEEKDDFINKLKNSHEE----MDNFHKKCEREERLILE 626

Query: 612  AQDRV-------LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
               +V         LE  VNEL   L E+ ++  Q D     K E L+        Q   
Sbjct: 627  LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQND----QKLEKLM-------VQMKV 675

Query: 665  LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
            L    +     ++   +E NK++++  Q++   +D +   SQ E  +   KE    LE+K
Sbjct: 676  LSEDKEVLSAEVKSLYEENNKLSSEKKQLS---RDLEVFLSQKEDVI--LKEHITQLEKK 730

Query: 725  TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
                  Q+   E D+L      EQ +Q L  + QL   L+   +E+S+  E EK++V+  
Sbjct: 731  L-----QLMVEEQDNLNKLLENEQ-VQKLFVKTQLYGFLKEMGSEVSEDSE-EKDVVNV- 782

Query: 785  RLDLQKKSEALESIKQK---LTKQEEEKQI-LKQDFETLSQETKIQHEELNNRIQTTVTE 840
               LQ   E+L  I ++   L  Q +EK + L+++ + L +E+ +Q EEL + ++    E
Sbjct: 783  ---LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRD--YE 837

Query: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
             +KV + KE  + E+ + K+ L      +KN+  +   ENQ     + ++ +TC   K +
Sbjct: 838  QEKVLLRKE--LEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCS--KSE 893

Query: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
            +  + E    ++ E  K L ++KE   + + EL  +++ L ++ +         ++L+  
Sbjct: 894  IHNEKEKCFIKEHENLKPLLEQKELRDR-RAELILLKDSLAKSPSVKNDPLSSVKELEEK 952

Query: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELEN--KLQQQLTQAAQELAAEKEKISVLQ 1018
            I  L++  ++K+++I  ++    +AV  K EL++  K  Q + +  + L +EK+++S   
Sbjct: 953  IENLEKECKEKEEKINKIK---LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASM 1009

Query: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE-----------------EKLSLAQE 1061
             +  +  E++K L  ++  +  +L   ++   + E                 E ++   E
Sbjct: 1010 RDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE 1069

Query: 1062 DLISNRNQIGNQNKLIQ----ELKTAKA----TLEQDSAKKEQQLQERCKALQDI----- 1108
            DL++    + +  KL++    E++ AKA     LE +  +KEQ+++E    + ++     
Sbjct: 1070 DLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129

Query: 1109 -------QKEKSLKEKELVNEKSKLAEIEEIKCRQ-EKEITKLNEEL--KSHKLESIKEI 1158
                   Q +K+++E ELV + ++   +  ++    E+ + +LN++L  K++K+E +++ 
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189

Query: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQ-EKRNQQILKDQVKKEEE-----ELKKEFI 1212
              ++  KQ  +Q+++       SL+++V+Q E++N +I +  VK ++E     + + + +
Sbjct: 1190 IKIQKQKQETLQEEI------TSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL 1243

Query: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS----QRRVSELE 1268
              +A L  E++  +  ++ ++   A++T +   ++E+L T  ++ Q +    Q+RV+ L+
Sbjct: 1244 ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQ 1303

Query: 1269 KQTDDLRGEIAVLEATVQN---------NQDERRALLERCLKG--------EGEIEKLQT 1311
            ++    + E A + +  ++          Q + +++ +   +G        E  I++L+ 
Sbjct: 1304 EECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKI 1363

Query: 1312 KVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRR 1371
            K+ + Q  L    + +Q L  E+ +L  +H + L    +++ E++  +   +  ++ ++ 
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS 1423

Query: 1372 HH 1373
             H
Sbjct: 1424 EH 1425



 Score =  200 bits (509), Expect = 7e-51
 Identities = 297/1379 (21%), Positives = 595/1379 (43%), Gaps = 220/1379 (15%)

Query: 83   DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
            D+V  L++E++ ++   +E+  Y   L+K+L+                TD   E  +  Q
Sbjct: 178  DNVKKLQEEIEKIRPGFEEQILY---LQKQLDA--------------TTDEKKETVTQLQ 220

Query: 143  QLEEAQTENF--NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
             + EA ++++  NI  +++   Q  A    E+ ++  + +      EA   K+  L E L
Sbjct: 221  NIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENL 280

Query: 201  NKEATVIQDLKTELLQRPGIEDVAVLKKE-------------LVQVQTLMDNMTLERERE 247
             K+     +   + +Q+    ++  L+K              L+Q  T ++ +  E+ + 
Sbjct: 281  VKQC----EASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336

Query: 248  SEKLKDECKKLQSQYA--SSEAT-ISQLRSELAKGPQEVA-VYVQELQKLKSSVNEL--T 301
               L+D  K+L+SQ++    E T ++ L+ +L    Q +   +  E + L+  +NEL   
Sbjct: 337  ---LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLA 393

Query: 302  QKNQTLTENLLKKE-----QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356
            ++ Q      LK E     + +    E+HN E  S K      HQK++  +  ++ LS S
Sbjct: 394  KEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE----QHQKEIS-ELNETFLSDS 448

Query: 357  ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ--------REEKEQH 408
            E     +  E+    E  + L++E  E    Y+ L+   + LQ +         +E E  
Sbjct: 449  EKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESM 508

Query: 409  GLQLQSEINQLHSKL----------LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADL 458
              Q  S++++L  KL          LET  +L   + +L  Q++L  E     E  + +L
Sbjct: 509  KQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPEL----ENTIKNL 564

Query: 459  Q-------LKLSRLEEQLKE---KVTNSTELQHQ-LDKTKQQHQEQQALQQSTTAKLR-- 505
            Q       L LS+ +  LKE   K+ + TE +   ++K K  H+E     +    + R  
Sbjct: 565  QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624

Query: 506  -EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
             E    +EQ ++   + +QK+  L   L+++     L EK++ D     Q  E     + 
Sbjct: 625  LELGKKVEQTIQYNSELEQKVNELTGGLEET-----LKEKDQND-----QKLEKLMVQMK 674

Query: 565  QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ-----KAHLRAAQDRVLSL 619
             L E    L  +V  L E+    S   KQ   +L   + ++     K H+   + ++  +
Sbjct: 675  VLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 734

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELL-----LSAEAAKTAQRADLQNHLDTAQN 674
                + LN  L    E+V +L +    KT+L      + +E ++ ++  D+ N L     
Sbjct: 735  VEEQDNLNKLLEN--EQVQKLFV----KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE 788

Query: 675  ALQDKQQELNKITTQLDQVTAKLQDK----QEH----CSQLESHLKEYKEKYLSLEQKTE 726
            +L    +E   +  Q D+   +L+ +    QE     C +L+S L++Y+++ + L ++ E
Sbjct: 789  SLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE 848

Query: 727  ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE---IVSS 783
            E++ + + L++D LE+K + E+    L+ Q  L    E+  T    ++  EKE   I   
Sbjct: 849  EIQSEKEALQSDLLEMKNANEKTR--LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEH 906

Query: 784  TRL-------DLQKKSEALESIKQKLTKQEEEK-------QILKQDFETLSQETKIQHEE 829
              L       +L+ +   L  +K  L K    K       + L++  E L +E K + E+
Sbjct: 907  ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEK 966

Query: 830  LNN----------RIQTTVTELQKVKMEKEALMTE---LSTVKDKLSKVSDSLKNSKSEF 876
            +N            + ++  E Q VK E E+L +E   LS     L + ++S KN   E+
Sbjct: 967  INKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026

Query: 877  EKENQK---GKAAILDLEKTCKELKHQLQ---VQMENTLKEQKELKKSLEKEKEASHQLK 930
            EK++++    K    + E   ++L  QL+   +Q E    + ++L   +E  +  +  L+
Sbjct: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLE 1086

Query: 931  LELNSMQEQLIQAQNTLK----QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
            +++  +Q         L+    Q E++ ++    +NEL++   Q +K+ + LQ       
Sbjct: 1087 VQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQ-----KT 1141

Query: 987  LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
            +Q+ EL  K  QQ T    E+A           +YE+     K+L      + +++    
Sbjct: 1142 MQELELVKKDAQQTTLMNMEIA-----------DYER---LMKELNQKLTNKNNKIEDLE 1187

Query: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
            Q++K  ++K    QE++ S ++ +    +   ++K      +++ A  +Q   +      
Sbjct: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247

Query: 1107 DIQKEKSLKEKELVNEKSKLAEI--------EEIKCRQE----------KEITKLNEELK 1148
             ++ E    ++++   K +LAEI        E +K   E          + +T L EE +
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307

Query: 1149 SHKLESIKEITNLKDAK----QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
            + K E     +  +  K     +L QQK +   +A++     +QE+ + ++L DQ+K + 
Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET--EGAKQEREHLEMLIDQLKIKL 1365

Query: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE----WQSS 1260
            ++ +       ++L +   E +  +++H +   +   +   L E L +++ E        
Sbjct: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425

Query: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
             + VS+L  Q + LR         V++ Q+E R  +E     + ++ K++ ++ +L+ +
Sbjct: 1426 TQTVSQLTSQNEVLRNS---FRDQVRHLQEEHRKTVETL---QQQLSKMEAQLFQLKNE 1478



 Score =  190 bits (483), Expect = 7e-48
 Identities = 290/1272 (22%), Positives = 587/1272 (46%), Gaps = 163/1272 (12%)

Query: 152  FNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK 211
            F  KQM  +  QKA    TE+         E+ + E   + VT  T ++ K  T  + L 
Sbjct: 33   FAKKQM--MLIQKAKSRCTEL---------EKEIEELRSKPVTEGTGDIIKALT--ERLD 79

Query: 212  TELLQRPGIEDVAV-LKKELVQV-QTLMDNMTLERERESEKLKDECKKLQSQYASSEATI 269
              LL++   E   + LKKE +++ Q + D++T        K+ D  K+L+  + +    I
Sbjct: 80   ALLLEKAETEQQCLSLKKENIKMKQEVEDSVT--------KMGDAHKELEQSHINYVKEI 131

Query: 270  SQLRSEL----AKGPQEVAVYVQELQKLKSSVNELTQ--KNQTLTENLLKKEQDYTKLEE 323
              L++EL    +K  ++ A   ++L++  ++  EL++  K Q  +E+ +KK Q+  +   
Sbjct: 132  ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIR 191

Query: 324  KHNEESVS--KKNIQATLHQKDLDCQQLQSRLSAS----ETSLHRIHVELSE-KGEATQK 376
               EE +   +K + AT  +K     QLQ+ + A+    + +++ +  EL + K    ++
Sbjct: 192  PGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEE 251

Query: 377  LKEELSEVETKYQHLKAEFKQLQQQRE------EKEQHGLQLQSEI-------------- 416
            +KE + ++E   +  +AE  +L + +E      E  +  +Q + E               
Sbjct: 252  VKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311

Query: 417  -NQLHSKLLE----TERQLGEAHGRLKEQ-RQLSSEK--LMDKEQQVADLQLKLSRLEEQ 468
             NQ+ S LL+     E+ + E    L++  ++L S+   L D+   + +L+LKL    + 
Sbjct: 312  DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH 371

Query: 469  LKEKVTNSTE-LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
            +K++  +  E L+ ++++     +EQ  + +   ++L       +Q    +   ++++Q+
Sbjct: 372  IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLN---KQFCYTVEQHNREVQS 428

Query: 528  LEALLQK--SKENISLL---EKEREDLYAKIQA---------GEGETAVLN--QLQEKNH 571
            L+   QK  S+ N + L   EKE+  L  +IQ           E + A+LN   L+E   
Sbjct: 429  LKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIME 488

Query: 572  TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL---NS 628
             LQ ++ +   K+  + ES KQ Q +    V E +  LR A     +L  +VN L   N 
Sbjct: 489  ILQTELGESAGKISQEFESMKQQQAS---DVHELQQKLRTAFTEKDALLETVNRLQGENE 545

Query: 629  QLNESKEKVSQLDIQIKAKTE----LLLSAEAAKTAQRADLQNHLDTAQNAL-QDKQQEL 683
            +L   +E V +L+  IK   E     LLS      +QR  +   L+   N+L ++K   +
Sbjct: 546  KLLSQQELVPELENTIKNLQEKNGVYLLSL-----SQRDTMLKELEGKINSLTEEKDDFI 600

Query: 684  NKITT---QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
            NK+     ++D    K + ++    +L   +++  +    LEQK  EL G ++    ++L
Sbjct: 601  NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE----ETL 656

Query: 741  EVKASKEQALQDLQ-QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES-- 797
            + K   +Q L+ L  Q + L+ D E+ + E+ K L  E   +SS +  L +  E   S  
Sbjct: 657  KEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV-KSLYEENNKLSSEKKQLSRDLEVFLSQK 715

Query: 798  ----IKQKLTKQEEEKQILKQDFETLS---QETKIQH----EELNNRIQTTVTELQKVKM 846
                +K+ +T+ E++ Q++ ++ + L+   +  ++Q      +L   ++   +E+ +   
Sbjct: 716  EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE 775

Query: 847  EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
            EK+ ++  L  V + L+K+++   N    F+++ +     +L+LEK  K L+ +  VQ E
Sbjct: 776  EKD-VVNVLQAVGESLAKINEEKCNLA--FQRDEK-----VLELEKEIKCLQEESVVQCE 827

Query: 907  ---NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
               + L++ ++ K  L KE E   +++ E  ++Q  L++ +N  ++   E Q L   + E
Sbjct: 828  ELKSLLRDYEQEKVLLRKELE---EIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884

Query: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
            + Q+  + +   E    + K  + +   L+  L+Q+      EL   + ++ +L+++  K
Sbjct: 885  VSQTCSKSEIHNE----KEKCFIKEHENLKPLLEQK------ELRDRRAELILLKDSLAK 934

Query: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
            S        S     E ++    ++ K  EEK++  +   +  + ++ +  K   E +T 
Sbjct: 935  SPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK---ETQTV 991

Query: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSL------KEKELVNEKSKLAEIE---EIKC 1134
            K  LE   ++K+Q        +Q  +  K+L      + ++L  EK +    E   E   
Sbjct: 992  KEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLT 1051

Query: 1135 RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
            RQ +  T   E + S   + +  I  L+   +LL  Q LE+Q      KA V++E   ++
Sbjct: 1052 RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ----RAKAMVDKELEAEK 1107

Query: 1195 ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
            + K+Q  KE      E  E + +L  E K+ +  M++ E  + K   Q T +N  +   +
Sbjct: 1108 LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK-KDAQQTTLMNMEIADYE 1166

Query: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314
            +  +   ++++    + +DL  EI + +   +  Q+E  +L     + E +  K++  ++
Sbjct: 1167 RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLV 1226

Query: 1315 ELQRKLDNTTAA 1326
            + +++L ++  A
Sbjct: 1227 KTKKELADSKQA 1238



 Score =  178 bits (451), Expect = 4e-44
 Identities = 277/1336 (20%), Positives = 566/1336 (42%), Gaps = 262/1336 (19%)

Query: 86   TLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK-PDGLVTDSSAELQSLEQQL 144
            ++L QE   ++  + E+  + E+  KELE    + + E    + L      + Q ++ + 
Sbjct: 317  SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376

Query: 145  -EEAQTENFNIKQMKDLFEQKAA---QLATEIADIKSKY--------DEERSLREAAEQK 192
              E +   F I ++    E++     +L +E+A +  ++         E +SL+E  +++
Sbjct: 377  FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436

Query: 193  VTRLTE----ELNKEATV----IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244
            ++ L E    +  KE       IQ LK +       +  A+L  E   ++ +M+ +  E 
Sbjct: 437  ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYE--SLREIMEILQTEL 494

Query: 245  ERESEKLKDECKKLQSQYASSEATISQ-LRSELAK------------GPQEVAVYVQEL- 290
               + K+  E + ++ Q AS    + Q LR+   +            G  E  +  QEL 
Sbjct: 495  GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554

Query: 291  QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
             +L++++  L +KN     +L +++    +LE K N  +  K +    L     +     
Sbjct: 555  PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614

Query: 351  SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL 410
             +    E    R+ +EL +K E T +     SE+E K   L      L++  +EK+Q+  
Sbjct: 615  KKCEREE----RLILELGKKVEQTIQYN---SELEQKVNELTGG---LEETLKEKDQNDQ 664

Query: 411  QLQSEINQLHSKLLETERQL--GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE- 467
            +L+  + Q+  K+L  ++++   E     +E  +LSSEK    +Q   DL++ LS+ E+ 
Sbjct: 665  KLEKLMVQM--KVLSEDKEVLSAEVKSLYEENNKLSSEK----KQLSRDLEVFLSQKEDV 718

Query: 468  -------QLKEKVTNSTELQHQLDKTKQQHQEQQAL----------QQSTTAKLREAQND 510
                   QL++K+    E Q  L+K  +  Q Q+            +  +       + D
Sbjct: 719  ILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD 778

Query: 511  LEQVLRQIGD---------------KDQKIQNLE------------------ALLQKSKE 537
            +  VL+ +G+               +D+K+  LE                  +LL+  ++
Sbjct: 779  VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ 838

Query: 538  NISLLEKEREDLYAKIQAGEGETAVLNQLQEK------NHTLQ-EQVTQLTEKLKNQSES 590
               LL KE E++ ++ +A + +   +    EK      N  +Q E+V+Q   K +  +E 
Sbjct: 839  EKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898

Query: 591  HK---QAQENL-----HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642
             K   +  ENL       ++++++A L   +D +    +  N+  S + E +EK+  L+ 
Sbjct: 899  EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958

Query: 643  QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
            + K K E +   +      + +L    D+++   Q  ++EL  + ++ DQ++A ++D  +
Sbjct: 959  ECKEKEEKINKIKLVAVKAKKEL----DSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014

Query: 703  HCSQLESHLKEY----------KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
                 ++ L EY          KE+  + E + E+L  Q++        + +  E  L  
Sbjct: 1015 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLAR 1074

Query: 753  LQ----------------QQRQLNTDLELRATELSKQLEMEKEIVSSTRLD-----LQKK 791
            ++                Q+ +   D EL A +L K+ ++++   +   L+     LQK+
Sbjct: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKE 1134

Query: 792  SEALESIKQKL--TKQEEEKQILKQ----DFETLSQETKIQHEELNNRIQTTVTELQKVK 845
             + L+   Q+L   K++ ++  L      D+E L +E   +    NN+I+    E++  K
Sbjct: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194

Query: 846  MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
             ++E L  E++           SL++S  ++E++N K K  ++   KT KEL    Q + 
Sbjct: 1195 QKQETLQEEIT-----------SLQSSVQQYEEKNTKIKQLLV---KTKKELADSKQAET 1240

Query: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
            ++ +     L+ SL+ E EAS Q       ++   IQ      +  K  + L+ +  + +
Sbjct: 1241 DHLI-----LQASLKGELEASQQ------QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1289

Query: 966  QSSEQKKKQIEALQGELKIAVLQ-----------KTELENKLQQQ----LTQAAQELAA- 1009
            ++    ++++ ALQ E + A  +           K  + N L+QQ    ++QA  E A  
Sbjct: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQ 1349

Query: 1010 EKEKISVL-----------QNNYEKSQETFKQLQSDF--------------YGRESELLA 1044
            E+E + +L           QNN + +    + LQS+                 +E+EL  
Sbjct: 1350 EREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAEL-- 1407

Query: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLI------------QELKTAKATLEQDSA 1092
             R+ L S++ +  + + +     +Q+ +QN+++            +E +    TL+Q  +
Sbjct: 1408 -REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLS 1466

Query: 1093 KKEQQL---QERCKALQDIQKEKSLKE-KELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
            K E QL   +        +  ++SLK  +E  N    L ++  +   + + +   + E  
Sbjct: 1467 KMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESV 1526

Query: 1149 SHK---LESIKEITNLKDAK------------QLLIQQKLELQGKADSLKAAVEQEKRNQ 1193
            S      +S++++ N  + K            + L+Q+       AD L   + + +   
Sbjct: 1527 SSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATN 1586

Query: 1194 QILKDQVKKEEEELKK 1209
             IL +Q+K  + E+++
Sbjct: 1587 AILMEQIKLLKSEIRR 1602



 Score =  152 bits (385), Expect = 2e-36
 Identities = 253/1209 (20%), Positives = 500/1209 (41%), Gaps = 151/1209 (12%)

Query: 51   GSADELFKHYEAVHDAGNDSGHGGESN----LALKRDDVTLLRQEVQDLQASLKEEKW-Y 105
            G  ++L    E V +  N   +  E N    L+L + D  L  +E++    SL EEK  +
Sbjct: 542  GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML--KELEGKINSLTEEKDDF 599

Query: 106  SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS-------LEQQLEEAQTENFNIKQMK 158
              +LK   E+     ++  + + L+ +   +++        LEQ++ E         + K
Sbjct: 600  INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEK 659

Query: 159  DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218
            D  +QK  +L  ++  +          +E    +V  L EE NK ++  + L  +L    
Sbjct: 660  DQNDQKLEKLMVQMKVLSED-------KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712

Query: 219  GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE--ATISQLRSEL 276
              ++  +LK+ + Q++  +  M  E++  ++ L++E  ++Q  +  ++    + ++ SE+
Sbjct: 713  SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENE--QVQKLFVKTQLYGFLKEMGSEV 770

Query: 277  AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS-KKNI 335
            ++  +E           K  VN L    Q + E+L K  ++   L  + +E+ +  +K I
Sbjct: 771  SEDSEE-----------KDVVNVL----QAVGESLAKINEEKCNLAFQRDEKVLELEKEI 815

Query: 336  QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF 395
            +    +  + C++L+S L   E     +  EL E     + L+ +L E++   +  + E 
Sbjct: 816  KCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLEN 875

Query: 396  KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ-- 453
            + L  Q EE  Q     +SEI+    K    E +  +     KE R   +E ++ K+   
Sbjct: 876  QNLLIQVEEVSQ--TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLA 933

Query: 454  -----------QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA 502
                        V +L+ K+  LE++ KEK     +++    K K++    +   Q+   
Sbjct: 934  KSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE 993

Query: 503  KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
            +L   +++ +Q+   + D  Q  ++ + LL + ++    L+ E+E               
Sbjct: 994  ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE--------------- 1038

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKN---QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
                  + +  + ++  LT +L+N   Q E+     E+L  +++  +++ +  + ++L +
Sbjct: 1039 ------RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
            + +   ++ +L   K +  Q   +       L   +     ++  LQ  +   +   +D 
Sbjct: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152

Query: 680  QQ------ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
            QQ      E+      + ++  KL +K      LE  +K  K+K  +L+++   L+  ++
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212

Query: 734  KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
            + E  + ++K    +  ++L   +Q  TD  +    L  +LE  ++ V            
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV------------ 1260

Query: 794  ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK----VKMEKE 849
              E  K +L +   EK  + +  +T ++    QH+   +  Q  VT LQ+     K E+ 
Sbjct: 1261 --EVYKIQLAEITSEKHKIHEHLKTSAE----QHQRTLSAYQQRVTALQEECRAAKAEQA 1314

Query: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
             + +E  + K ++  V    KN KS  + E +  K     LE    +LK +LQ    N  
Sbjct: 1315 TVTSEFESYKVRVHNVLKQQKN-KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373

Query: 910  KEQKELKKSLEKEKEASHQLKLEL-NSMQEQLIQAQNTLKQN----EKEEQQLQGNINEL 964
                EL ++L+ E    H   LE  N M ++ +  +  L++     + E   ++   +E 
Sbjct: 1374 INVSEL-QTLQSE----HDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMK---SEH 1425

Query: 965  KQSSEQKKKQIEALQGELKIAVLQKTELENK----LQQQLTQAAQELAAEKEKISVLQNN 1020
             Q+  Q   Q E L+   +  V    E   K    LQQQL++   +L   K + +    +
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTT--RS 1483

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
               SQ++ K L+     R ++L        + EE   +   D  S  +       L Q L
Sbjct: 1484 PVSSQQSLKNLRE---RRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL 1540

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKS-----LKEKELVN----EKSKL--AEI 1129
             + +  LE      E   +E  + L    K        L+E E  N    E+ KL  +EI
Sbjct: 1541 NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI 1600

Query: 1130 EEIKCRQEKEITKLN-EELKSHKLESI-----KEITNLKDAKQLLIQQKLELQGKADSLK 1183
              ++  QE+E +  N E LK+  L+ I      E   L      ++Q   E +GK   L 
Sbjct: 1601 RRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGK---LA 1657

Query: 1184 AAVEQEKRN 1192
            A  + E+ N
Sbjct: 1658 AVAQGEEEN 1666



 Score =  103 bits (258), Expect = 9e-22
 Identities = 130/560 (23%), Positives = 246/560 (43%), Gaps = 55/560 (9%)

Query: 813  KQDFETLSQETKIQHEE----LNNRIQTTVTELQKV--KMEKEALMTELSTVKDKLSKVS 866
            K   ETL +E  I+  +    L  + ++  TEL+K   ++  + +      +   L++  
Sbjct: 19   KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERL 78

Query: 867  DSLKNSKSEFE-------KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
            D+L   K+E E       KEN K K  + D      +   +L+    N +KE + LK  L
Sbjct: 79   DALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL 138

Query: 920  EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK----KQI 975
               +    + K  L    E+ +  Q  L +  K +   + N+ +L++  E+ +    +QI
Sbjct: 139  MAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQI 198

Query: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQEL-----AAEKEKISVLQNNYEKSQETFKQ 1030
              LQ +L     +K E   +LQ  +   +Q       + ++E + +   + E+ +E   Q
Sbjct: 199  LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQ 258

Query: 1031 LQSDFYGRESE---LLATRQDL--------KSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
            +++     E+E   L   +++L        K++++K     E+L    +     N++   
Sbjct: 259  IEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQIC-- 316

Query: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
                 + L Q++   EQ + E+ K L+D  KE   +   L   K ++  +  +K + E +
Sbjct: 317  -----SILLQENTFVEQVVNEKVKHLEDTLKELESQHSIL---KDEVTYMNNLKLKLEMD 368

Query: 1140 ITKLNEELKSHKLE----SIKEITNLKDAKQLLIQQ-KLELQGKADSLKAAVEQEKRNQQ 1194
               + +E   H+ E     I E+   K+ +  +I++ K EL G        VEQ  R  Q
Sbjct: 369  AQHIKDEF-FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427

Query: 1195 ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN----EAKLTMQITALNENL 1250
             LK+Q +KE  EL + F+    K    +  +  G+K+  EN    + +  +   +L E +
Sbjct: 428  SLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM 487

Query: 1251 GTVKKEWQSSQRRVS-ELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
              ++ E   S  ++S E E        ++  L+  ++    E+ ALLE   + +GE EKL
Sbjct: 488  EILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL 547

Query: 1310 QTKVLELQRKLDNTTAAVQE 1329
             ++  EL  +L+NT   +QE
Sbjct: 548  LSQ-QELVPELENTIKNLQE 566



 Score =  100 bits (250), Expect = 8e-21
 Identities = 194/936 (20%), Positives = 391/936 (41%), Gaps = 233/936 (24%)

Query: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ-LNESKEKVSQLDIQIKAKTELLLS 653
            +E+L    ++Q   ++ A+ R   LE  + EL S+ + E    +      IKA TE L  
Sbjct: 27   KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDI------IKALTERL-- 78

Query: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
                     A L    +T Q  L  K++ + K+  +++    K+ D            KE
Sbjct: 79   --------DALLLEKAETEQQCLSLKKENI-KMKQEVEDSVTKMGDAH----------KE 119

Query: 714  YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
             ++ +++  ++ E L+ ++  + +   E KA+ ++ L++      +NT LEL     S+Q
Sbjct: 120  LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA-----MNTQLEL-----SEQ 169

Query: 774  LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
            L+ +    +++  +++K  E +E I+      EE+   L++  +  + E K         
Sbjct: 170  LKFQ----NNSEDNVKKLQEEIEKIRPGF---EEQILYLQKQLDATTDEKK--------- 213

Query: 834  IQTTVTELQKV-------------KMEKEALMTEL---STVKDKLSKVSDSLKNSKSEFE 877
               TVT+LQ +              +++E L  +      VK+ + ++  S K  ++E  
Sbjct: 214  --ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN 271

Query: 878  KENQKGKAAILDLEKTCKELKHQLQVQM----------------------ENTLKEQ--K 913
            K N+  +  +   E + K ++ + + ++                      ENT  EQ   
Sbjct: 272  KLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVN 331

Query: 914  ELKKSLE---KEKEASHQLKLE----LNSMQEQL-IQAQNTLKQNEKEEQQLQGNINELK 965
            E  K LE   KE E+ H +  +    +N+++ +L + AQ+   +   E + L+  INEL 
Sbjct: 332  EKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELL 391

Query: 966  QSSEQKKKQIEALQGEL---------------------------KIAVLQKTELENKLQQ 998
             + E++   IE L+ EL                           +I+ L +T L +  ++
Sbjct: 392  LAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKE 451

Query: 999  QLTQAAQELAAEKEKISVLQN-------NYEKSQETFKQLQSDF------YGRESELLAT 1045
            +LT    E+   KE+   LQ        NYE  +E  + LQ++         +E E +  
Sbjct: 452  KLT-LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQ 510

Query: 1046 RQ--DLKSVEEKLSLA---QEDLISNRNQIGNQN-------KLIQELKTAKATLEQDSAK 1093
            +Q  D+  +++KL  A   ++ L+   N++  +N       +L+ EL+     L++ +  
Sbjct: 511  QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGV 570

Query: 1094 KEQQLQERCKALQDIQ-KEKSLKEK--ELVNE-KSKLAEIEEI--KCRQEK----EITKL 1143
                L +R   L++++ K  SL E+  + +N+ K+   E++    KC +E+    E+ K 
Sbjct: 571  YLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630

Query: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK-- 1201
             E+   +  E  +++  L    +  +++K +   K + L   ++    ++++L  +VK  
Sbjct: 631  VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690

Query: 1202 ------------------------KEEEELKKEFIEKEAKLHSEIKE------------- 1224
                                    KE+  LK+   + E KL   ++E             
Sbjct: 691  YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQV 750

Query: 1225 -------------KEVGMKKHEENEAKLTMQI-TALNENLGTVKKEWQS----SQRRVSE 1266
                         KE+G +  E++E K  + +  A+ E+L  + +E  +       +V E
Sbjct: 751  QKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE 810

Query: 1267 LEKQTDDLRGEIAV----LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
            LEK+   L+ E  V    L++ +++ + E+  L +   + + E E LQ+ +LE++   + 
Sbjct: 811  LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEK 870

Query: 1323 TTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNC 1358
            T      L  +N  +Q++       K    NE + C
Sbjct: 871  T-----RLENQNLLIQVEEVSQTCSKSEIHNEKEKC 901


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  217 bits (553), Expect = 6e-56
 Identities = 249/1240 (20%), Positives = 528/1240 (42%), Gaps = 156/1240 (12%)

Query: 71   GHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
            G+      A ++  +T ++   ++  A LK   W    L  +++    + +QE       
Sbjct: 792  GYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEE------ 845

Query: 131  TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190
                 E+ + E++L + + +    +      E   +QL  E   ++ +   E  L   AE
Sbjct: 846  -----EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900

Query: 191  QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250
            +   RLT +  +   +  DL+        +E+     + L   +  M     E E + E+
Sbjct: 901  ELRARLTAKKQELEEICHDLEAR------VEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 251  LKDECKKLQSQYASSEATISQLRSEL-------AKGPQEVAVYVQELQKLKSSVNELTQK 303
             +   +KLQ +  ++EA + +L  E         K  +E  +    + +  +++ E  +K
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 304  NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363
            +++L +   K E   T LEE+   E   ++ ++ T  + + D   L  +++  +  +  +
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074

Query: 364  HVELSEKGEATQ----KLKEE----------LSEVETKYQHLKAEFKQLQQQREEKEQHG 409
             ++L++K E  Q    +++EE          + E+E++   L+ + +  +  R + E+  
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134

Query: 410  LQLQSEINQLHSKLLET-ERQLGEAHGRLKEQRQLS------SEKLMDKEQQVADLQLKL 462
              L  E+  L ++L +T +    +   R K +++++       E+    E Q+ +++ K 
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194

Query: 463  SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD 522
            S+  E+L E++  +  ++  L+K KQ  + ++           E  N+++ +L+  GD +
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERG----------ELANEVKVLLQGKGDSE 1244

Query: 523  QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE----TAVLNQLQEKNHTLQEQVT 578
             K + +EA LQ+ +   +  E+ R +L  K+   + E    T +L+Q   K+  L +  +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 579  QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
             L  +L++  E            +QE+     +   ++  +E   N    QL E +E   
Sbjct: 1305 ALESQLQDTQE-----------LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698
             L+ QI           A   AQ AD++  ++ +   L+  ++   K+   L+       
Sbjct: 1354 NLEKQI-----------ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE------- 1395

Query: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
                                  L Q+ EE      KLE     ++   +  L DL  QRQ
Sbjct: 1396 ---------------------GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434

Query: 759  LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
               +LE +  +   QL  E++ +S+   + + ++EA    ++K TK     + L++    
Sbjct: 1435 SACNLEKKQKKFD-QLLAEEKTISAKYAEERDRAEA--EAREKETKALSLARALEE---- 1487

Query: 819  LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
             + E K + E LN + +T + +L   K +    + EL   K  L +  + +K    E E 
Sbjct: 1488 -AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546

Query: 879  ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
            E Q  + A L LE   + +K Q +  ++   ++ +E KK L ++     +++ EL   ++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ---VREMEAELEDERK 1603

Query: 939  QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998
            Q   A    K+ E + + L+ +I+   ++ ++  KQ+  LQ ++K  + +  +     ++
Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663

Query: 999  QLTQAAQ----------ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
             L QA +          E+   +E+++  +    ++Q+   +L  +      +     ++
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723

Query: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ---DSAKKEQQLQERCKAL 1105
             + +E +++  +E+L     + GN   +   LK A   ++Q   D   +    Q+   A 
Sbjct: 1724 KRRLEARIAQLEEEL---EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780

Query: 1106 QDIQKEKSLKEKELVNEKSKLAEIE-EIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164
            Q ++++     KEL   K KL E+E  +K + +  IT L  E K  +LE  +++ N    
Sbjct: 1781 QQLERQ----NKEL---KVKLQEMEGTVKSKYKASITAL--EAKIAQLE--EQLDNETKE 1829

Query: 1165 KQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE 1224
            +Q   +Q    + K   +   V+ E+RN +  KDQ  K    LK        +L  +++E
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLK--------QLKRQLEE 1881

Query: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264
             E   ++   +  KL  ++    E    + +E  S + ++
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  213 bits (543), Expect = 8e-55
 Identities = 241/1163 (20%), Positives = 503/1163 (43%), Gaps = 127/1163 (10%)

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            K L+QV    + M + +E E  K++++    +++    E   SQL +E            
Sbjct: 835  KPLLQVSRQEEEM-MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKL---------- 883

Query: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
             +LQ+   +  EL  + + L   L  K+Q+   LEE  ++       ++A + +++  CQ
Sbjct: 884  -QLQEQLQAETELCAEAEELRARLTAKKQE---LEEICHD-------LEARVEEEEERCQ 932

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
             LQ+     + ++  +  +L E+  A QKL+ E    E K + L+ E   L+ Q  +  +
Sbjct: 933  HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS----SEKLMDKEQQVADLQLKLS 463
                L+  I +  + L E E +  ++  +LK + +       E+L  +E+Q  +L+    
Sbjct: 993  EKKLLEDRIAEFTTNLTEEEEK-SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051

Query: 464  RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
            +LE    +      ELQ Q+ + K Q  +++   Q+  A++ E        L++I + + 
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111

Query: 524  KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE-------TAVLNQLQEKNH----- 571
            +I  L+  L+  + + +  EK++ DL  +++A + E       TA   +L+ K       
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171

Query: 572  ---TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
               TL+E+      +++   + H QA E L +Q+++ K      +    +LE    EL +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231

Query: 629  QLN-------ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD----LQNHLDTAQNALQ 677
            ++        +S+ K  +++ Q++         E  +T + AD    LQ  LD     L 
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT-ELADKVTKLQVELDNVTGLLS 1290

Query: 678  DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
                + +K+T     + ++LQD QE        L+E   + LSL  K +++E +      
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQEL-------LQEENRQKLSLSTKLKQVEDEKNSFRE 1343

Query: 738  DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797
               E + +K    + +        D++ +  +    LE  +E+    + DL+  S+  E 
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403

Query: 798  IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
                  K E+ K  L+Q+ + L  +   Q +   N        L+K + + + L+ E  T
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN--------LEKKQKKFDQLLAEEKT 1455

Query: 858  VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE------LKHQLQVQMENTLKE 911
            +  K ++  D    +++E  ++  K  +    LE+  ++      L  Q + +ME+ +  
Sbjct: 1456 ISAKYAEERD---RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512

Query: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK------ 965
            + ++ KS+ + +++   L+ ++  M+ QL + ++ L+  E  + +L+ N+  +K      
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572

Query: 966  -----QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
                 + SE+KKKQ+          V Q  E+E +L+ +  Q +  +AA K K+ +   +
Sbjct: 1573 LQGRDEQSEEKKKQL----------VRQVREMEAELEDERKQRSMAVAARK-KLEMDLKD 1621

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
             E   ++  + + +   +  +L A  +D     +    ++E++++   +  N+ KL    
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE--NEKKL---- 1675

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
                 ++E +  + +++L    +A +  Q+E+     E+ N   K A   E K R E  I
Sbjct: 1676 ----KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731

Query: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL---QGKADSLKAAVEQEKRNQQILK 1197
             +L EEL+  +  +      LK A   + Q   +L   +  A   + A +Q +R  + LK
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791

Query: 1198 DQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW 1257
             ++++ E  +K ++      L ++I + E  +    +       Q+    + L  V  + 
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851

Query: 1258 QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317
               +R   + + Q D     +  L+  ++              + E E ++      +LQ
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLE--------------EAEEEAQRANASRRKLQ 1897

Query: 1318 RKLDNTTAAVQELGRENQSLQIK 1340
            R+L++ T     + RE  SL+ K
Sbjct: 1898 RELEDATETADAMNREVSSLKNK 1920



 Score =  206 bits (525), Expect = 1e-52
 Identities = 244/1110 (21%), Positives = 516/1110 (46%), Gaps = 152/1110 (13%)

Query: 318  YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
            + K +++     V ++N  A L  ++    +L +++      + R   E+  K E   K+
Sbjct: 799  FAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPL-LQVSRQEEEMMAKEEELVKV 857

Query: 378  KEE-------LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430
            +E+       L+E+ET    L AE  QLQ+Q + + +    L +E  +L ++L   +++L
Sbjct: 858  REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE----LCAEAEELRARLTAKKQEL 913

Query: 431  GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK--- 487
             E    L+ + +   E+    + +   +Q  +  LEEQL+E+ +   +LQ +   T+   
Sbjct: 914  EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKL 973

Query: 488  QQHQEQQALQQSTTAKLREAQNDLEQVLRQ----IGDKDQKIQNL-------EALLQKSK 536
            ++ +E+Q + +    KL + +  LE  + +    + ++++K ++L       EA++   +
Sbjct: 974  KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE 1033

Query: 537  ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
            E +   EK+R++L    +  EG++     L ++   LQ Q+ +L  +L  + E  + A  
Sbjct: 1034 ERLRREEKQRQELEKTRRKLEGDST---DLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090

Query: 597  NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
                +V+E+ A    A  ++  LE+ ++EL   L   +   ++ +   K K +L    EA
Sbjct: 1091 ----RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAE---KQKRDLGEELEA 1143

Query: 657  AKTAQRADLQNHLDT--AQNALQDK-QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
             KT    +L++ LD+  AQ  L+ K +QE+N +   L+          E     E+ ++E
Sbjct: 1144 LKT----ELEDTLDSTAAQQELRSKREQEVNILKKTLE----------EEAKTHEAQIQE 1189

Query: 714  YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR-QLNTDLELRATELSK 772
             ++K+    Q  EEL  Q+++ +     VKA+ E+A Q L+ +R +L  ++++   +   
Sbjct: 1190 MRQKH---SQAVEELAEQLEQTK----RVKANLEKAKQTLENERGELANEVKV-LLQGKG 1241

Query: 773  QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI--------LKQDFETLSQETK 824
              E +++ V +   +LQ K    E ++ +L  +  + Q+        L Q     S+ TK
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301

Query: 825  IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN---SKSEFEKENQ 881
                 L +++Q T   LQ+   +K +L T+L  V+D+ +   + L+    +K   EK+  
Sbjct: 1302 -DFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360

Query: 882  KGKAAILDLEK----------TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL 931
               A + D++K          T +E+K +LQ  +E   +  +E   + +K ++   +L+ 
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420

Query: 932  ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE-----LKQSSEQKKKQIEALQGELKI-- 984
            EL+ +   L   + +    EK++++    + E      K + E+ + + EA + E K   
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480

Query: 985  -------AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ----LQS 1033
                   A+ QK ELE +L +Q     ++L + K+ +    +  EKS+   +Q    +++
Sbjct: 1481 LARALEEAMEQKAELE-RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539

Query: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDL---ISNRNQIGNQNK--LIQELKTAKATLE 1088
                 E EL AT      +E  L   +      +  R++   + K  L+++++  +A LE
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599

Query: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK-----CRQEKEITKL 1143
             +  ++   +  R K   D++  ++  +    N    + ++ +++     C +E + T+ 
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659

Query: 1144 N-EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
            + EE+ +   E+ K++ ++ +A+ + +Q++L          AA E+ KR  Q  +D++  
Sbjct: 1660 SREEILAQAKENEKKLKSM-EAEMIQLQEEL----------AAAERAKRQAQQERDELAD 1708

Query: 1203 EEE----------ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
            E            E K+    + A+L  E++E++   +   +   K  +QI  +N +L  
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768

Query: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
             +   Q ++    +LE+Q  +L+ ++  +E TV++             K +  I  L+ K
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS-------------KYKASITALEAK 1815

Query: 1313 VLELQRKLDNTT----AAVQELGRENQSLQ 1338
            + +L+ +LDN T    AA +++ R  + L+
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLK 1845



 Score =  199 bits (505), Expect = 2e-50
 Identities = 222/986 (22%), Positives = 452/986 (45%), Gaps = 135/986 (13%)

Query: 92   VQDLQASLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
            + DL+  L+ E+   +EL+K   K +G    L  Q A+    + +   +L   E++L+ A
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 148  QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207
                      K++  +K  +L ++I++++   + ER+ R  AE++   L EEL       
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL------- 1141

Query: 208  QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267
            + LKTEL             ++ +        +  +RE+E   LK   K L+ +  + EA
Sbjct: 1142 EALKTEL-------------EDTLDSTAAQQELRSKREQEVNILK---KTLEEEAKTHEA 1185

Query: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327
             I ++R + ++  +E+A  +++ +++K++   L +  QTL     +   +   L +   +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKAN---LEKAKQTLENERGELANEVKVLLQGKGD 1242

Query: 328  ESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV--- 384
                +K ++A L       Q+LQ + +  E    R+  EL++K     KL+ EL  V   
Sbjct: 1243 SEHKRKKVEAQL-------QELQVKFNEGE----RVRTELADK---VTKLQVELDNVTGL 1288

Query: 385  ----ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
                ++K   L  +F  L+ Q ++ ++    L  E N+    L    +Q+ +     +EQ
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQE----LLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344

Query: 441  RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV-------TNSTELQHQLDKTKQQHQEQ 493
             +   E   + E+Q+A L  +++ +++++++ V           +LQ  L+   Q+H+E+
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK 1404

Query: 494  QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK------SKENISLLEKERE 547
             A            Q +L+ +L  +  + Q   NLE   +K       ++ IS    E  
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464

Query: 548  DLYAKIQAGEGETAVLNQLQEKNHTLQE--QVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
            D  A+ +A E ET  L+  +     +++  ++ +L ++ + + E    +++++   V E 
Sbjct: 1465 DR-AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523

Query: 606  KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
            +   RA + +V  ++T + EL  +L  +++          AK  L ++ +A K     DL
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATED----------AKLRLEVNLQAMKAQFERDL 1573

Query: 666  QNHLDTAQNALQDKQQELNK--ITTQLDQVTAKLQDKQEHCS-------QLESHLKEYKE 716
            Q          +D+Q E  K  +  Q+ ++ A+L+D+++  S       +LE  LK+ + 
Sbjct: 1574 QG---------RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624

Query: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE- 775
               S  +  +E   Q++KL+A         +  +++L   R    ++  +A E  K+L+ 
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQM-------KDCMRELDDTRASREEILAQAKENEKKLKS 1677

Query: 776  MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
            ME E++      LQ++  A E  K++  ++ +E   L  +    S +  +  EE   R++
Sbjct: 1678 MEAEMIQ-----LQEELAAAERAKRQAQQERDE---LADEIANSSGKGALALEE-KRRLE 1728

Query: 836  TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN---QKGKAAILDLEK 892
              + +L++ ++E+E   TEL  + D+L K +  +    ++   E    QK + A   LE+
Sbjct: 1729 ARIAQLEE-ELEEEQGNTEL--INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
              KELK +LQ +ME T+K +   K S+   +    QL+ +L++  ++   A   +++ EK
Sbjct: 1786 QNKELKVKLQ-EMEGTVKSK--YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN----------KLQQQLTQ 1002
            + + +   +++ ++++EQ K Q +     LK    Q  E E           KLQ++L  
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETF 1028
            A +   A   ++S L+N   +    F
Sbjct: 1903 ATETADAMNREVSSLKNKLRRGDLPF 1928



 Score =  129 bits (325), Expect = 2e-29
 Identities = 153/667 (22%), Positives = 285/667 (42%), Gaps = 121/667 (18%)

Query: 700  KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
            ++E     E  L + +EK L+ E +  E+E    +L A+ L+           LQ+Q Q 
Sbjct: 843  QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ-----------LQEQLQA 891

Query: 760  NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
             T+L   A EL  +L  +K+ +     DL+ + E  E   Q L  ++++ Q   Q+ E  
Sbjct: 892  ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951

Query: 820  SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
             +E +   ++L  +++   TE +  K+E+E ++ E    K  L+K    L++  +EF   
Sbjct: 952  LEEEESARQKL--QLEKVTTEAKLKKLEEEQIILEDQNCK--LAKEKKLLEDRIAEFT-- 1005

Query: 880  NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
                                         L E++E  KSL K K          N  +  
Sbjct: 1006 ---------------------------TNLTEEEEKSKSLAKLK----------NKHEAM 1028

Query: 940  LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
            +   +  L++ EK+ Q+L+    +L+  S     QI  LQ ++    +Q  + E +LQ  
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
            L +  +E A +   +                                + ++ +E ++S  
Sbjct: 1089 LARVEEEAAQKNMAL--------------------------------KKIRELESQISEL 1116

Query: 1060 QEDLIS---NRNQIGNQNK-LIQELKTAKATLEQ--DSAKKEQQLQERCKALQDIQKEKS 1113
            QEDL S   +RN+   Q + L +EL+  K  LE   DS   +Q+L  R K  Q++   K 
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL--RSKREQEVNILKK 1174

Query: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ-- 1171
              E+E    K+  A+I+E++ +  + + +L E+L+  K    +   NL+ AKQ L  +  
Sbjct: 1175 TLEEE---AKTHEAQIQEMRQKHSQAVEELAEQLEQTK----RVKANLEKAKQTLENERG 1227

Query: 1172 ------KLELQGKADSLKAAVEQEKRNQQILKDQVK-KEEEELKKEFIEKEAKLHSEIKE 1224
                  K+ LQGK DS     +++K   Q+ + QVK  E E ++ E  +K  KL  E+  
Sbjct: 1228 ELANEVKVLLQGKGDS---EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284

Query: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284
                + + +   +KLT   +AL   L   ++  Q   R+   L  +   +  E       
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344

Query: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQA 1344
            ++  ++ +  L       E +I  L  +V ++++K++++   ++      + LQ K  + 
Sbjct: 1345 LEEEEEAKHNL-------EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ-KDLEG 1396

Query: 1345 LNRKWAE 1351
            L+++  E
Sbjct: 1397 LSQRHEE 1403



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 96/458 (20%), Positives = 202/458 (44%), Gaps = 42/458 (9%)

Query: 77   NLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE 136
            +L   +DDV    + V +L+ S +  +   EE+K +LE+ +   + +A  D  +      
Sbjct: 1508 DLMSSKDDVG---KSVHELEKSKRALEQQVEEMKTQLEELE--DELQATEDAKLR-LEVN 1561

Query: 137  LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
            LQ+++ Q E       +++   +  E+K  QL  ++ +++++ ++ER  R  A     +L
Sbjct: 1562 LQAMKAQFER------DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615

Query: 197  TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
              +L      I        +   I+ +  L+ ++      +D+    RE    + K+  K
Sbjct: 1616 EMDLKDLEAHIDSANKN--RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673

Query: 257  KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
            KL+S     EA + QL+ ELA   +      QE  +L   +   + K     E   + E 
Sbjct: 1674 KLKSM----EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729

Query: 317  DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
               +LEE+  EE  + + I   L + +L   Q+ + L+     L R H + +E   A Q+
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN-----LERSHAQKNEN--ARQQ 1782

Query: 377  LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436
            L+ +  E++ K Q ++   K              + ++ I  L +K+ + E QL      
Sbjct: 1783 LERQNKELKVKLQEMEGTVKS-------------KYKASITALEAKIAQLEEQLDNE--- 1826

Query: 437  LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
              ++RQ + +++   E+++ D+ L++       ++    + +   +L + K+Q +E +  
Sbjct: 1827 -TKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885

Query: 497  QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534
             Q   A  R+ Q +LE         ++++ +L+  L++
Sbjct: 1886 AQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  217 bits (553), Expect = 6e-56
 Identities = 299/1418 (21%), Positives = 623/1418 (43%), Gaps = 208/1418 (14%)

Query: 75   ESNLALKRDDVTL---LRQEVQDLQASLKE----EKWYSEELKKELEKYQGLQQQ---EA 124
            E  LAL+++   L   L++ +   +A LK+    E+   EELK++ + Y  LQ+Q   ++
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS 1223

Query: 125  KPDGLVTDSSAELQ------------------------SLEQQLEEAQTENFNIKQMKDL 160
            K +  + D   +LQ                         LE+ L +A  ++     ++  
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN 1283

Query: 161  F---------EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK 211
                      +  A Q  T +A IK++  E  + +   E KV+  T EL K++  +  L+
Sbjct: 1284 LCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343

Query: 212  TELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE----- 266
             ++             K+ +++++L   ++ E E  +E L+ + +  Q Q A  E     
Sbjct: 1344 EQI------------NKQGLEIESLK-TVSHEAEVHAESLQQKLESSQLQIAGLEHLREL 1390

Query: 267  -ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
               + +L+  ++K  ++V+    +L + ++++ ++ Q      E+L+K      +++ K 
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI-QTEIIEQEDLIKALHTQLEMQAKE 1449

Query: 326  NEESVSKKNIQ-ATLHQKDLDC-------QQLQSRLSASETSLHR-------IHVELSEK 370
            ++E + +  ++   + QK  +        QQ+Q +L A+  S          +  ELS  
Sbjct: 1450 HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLA 1509

Query: 371  GEATQKLKEELSEVETKYQHLKAE-------FKQLQQQRE----EKEQHGLQLQSEINQL 419
                ++L + L++VE++      E          LQ++R+    E ++  L+ QS  +  
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569

Query: 420  HSKLLETERQLGEAHGRLKEQRQLSSEKLMDK---EQQVADLQLKLSRLEEQLKEKVTNS 476
             S  L  E    +    +KE   L S K+ +    +++  +LQ +   L +  +     +
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629

Query: 477  TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
              +QH ++  +Q+ QE     +ST A  +E +  L++  +++ +  +K++      +  +
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA---KSKQ 1686

Query: 537  ENISLLEKEREDLYAKIQ-AGEGETAVLNQLQEKNHTLQEQVTQLT---EKLKNQSESHK 592
            + I  LE+E + L A++  AG+     +  L   N +++E++ ++    E L  + +S  
Sbjct: 1687 QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM 1746

Query: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLE--------TSVNELNSQL--NESKEKVSQLDI 642
              +++L ++VQ+ K  +     +  +LE        T+V E  +Q    E++E+ S    
Sbjct: 1747 SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806

Query: 643  QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
                 +E + SA++A  A   D  +H             E+N    Q+DQ+  ++   +E
Sbjct: 1807 TRPTCSESVPSAKSANPAVSKDFSSH------------DEINNYLQQIDQLKERIAGLEE 1854

Query: 703  HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
               + +   +  + +  +L  +    +G++K L+ +  ++    +Q  ++L +  +L   
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914

Query: 763  LELRATELSKQL-----EMEKEIVSSTR--LDLQKKSEALES----IKQKLTKQEEEKQI 811
             E    +L ++L     E+   I +  +   D Q K+E LES    +K+ +++ EEEKQ 
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974

Query: 812  LKQDFETLSQET------KIQHEELNNRIQTTVTELQKVKMEKEALMTELST----VKDK 861
            L ++   +  E       KIQ  +     ++   ELQ++  EK+  + +L       ++K
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034

Query: 862  LSKVSDSLK---------NSKSEFEKEN-----QKGKAAILDLEKTCKELKHQLQVQMEN 907
            +S +  ++K             E  KEN     +  K A  +L  + K L    Q +   
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA-SFKVLLDDTQSEAAR 2093

Query: 908  TLKEQKELKKSLEKEKEA-SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
             L +  +LKK L+  KE+   Q+K +   ++ +L QA+   +++ KE++ +Q  ++ L++
Sbjct: 2094 VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE---EKHLKEKKNMQEKLDALRR 2150

Query: 967  SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
                +K  +E   GE+++ + +K +   +LQ+ L     +LAA  + +S LQ++ ++  +
Sbjct: 2151 ----EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206

Query: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT 1086
              K+ +  F             ++S EE++ L +++    ++Q+   +  ++ELK   + 
Sbjct: 2207 EAKKWERKF----------SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256

Query: 1087 LEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146
            LE D    E + Q   +  Q +      + KEL+   S+L E   +    + E+ KL  E
Sbjct: 2257 LEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL---SQLEETRHLYHSSQNELAKLESE 2313

Query: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
            LKS K     ++T+L ++ +   +QK  L+G     +A ++  K + + L+  ++     
Sbjct: 2314 LKSLK----DQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR-- 2367

Query: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW-QSSQRRVS 1265
                  E  ++LH EI  K          E K+   ++   E +     E  Q   + + 
Sbjct: 2368 ------ELTSRLHEEINMK----------EQKIISLLSGKEEAIQVAIAELRQQHDKEIK 2411

Query: 1266 ELEKQTDDLRGEIAVLEATVQNNQDERRALLE--RCLKGEGEIEKLQ-----TKVLELQR 1318
            ELE        E  VLE   +   D+   L+E  + +K E   +K Q       +  LQ 
Sbjct: 2412 ELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQN 2471

Query: 1319 KLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
              D      Q+L   + S+ ++  Q +    AE+N+++
Sbjct: 2472 DRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509



 Score =  215 bits (547), Expect = 3e-55
 Identities = 285/1308 (21%), Positives = 564/1308 (43%), Gaps = 155/1308 (11%)

Query: 85   VTLLRQEVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
            V  +RQE Q+L   L+  +   +E +K+L E  Q +++ + K          ++  LE++
Sbjct: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
             +  + E   +    D  ++    L +  A +K + +  +   E   +K   L  E +  
Sbjct: 1696 NDRLRAE---VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752

Query: 204  ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
            +  +QDLK ++       +  V K+  ++     DN T   E  ++ +  E ++  S   
Sbjct: 1753 SEEVQDLKHQI-------EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805

Query: 264  SSEATISQ-LRSELAKGP---------QEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
            S+  T S+ + S  +  P          E+  Y+Q++ +LK  +  L ++ Q   E    
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865

Query: 314  KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA----SETSLH-------R 362
             E +   L  + + +    K +Q  + + +L  QQ+Q  LS      ET+         R
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  +L+E   +     +++++ + K + L++E K L++   E E+   QL  E  ++ S+
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE 1985

Query: 423  LLETERQLGEAHGRLKEQRQLSSEK-----LMDKEQQVADLQL-------KLSRLEEQLK 470
            +   +  L +  G  KE    S  K     L +K+Q+V  LQ        K+S LE  +K
Sbjct: 1986 I--RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043

Query: 471  EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA 530
                  TE Q  L+ TK+                     +L Q +        ++ + + 
Sbjct: 2044 ALEFVQTESQKDLEITKE---------------------NLAQAVEHRKKAQAELASFKV 2082

Query: 531  LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590
            LL  ++   + +  +   L  ++Q+ +   +V +Q+++K+  L+ ++ Q  EK     + 
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNK--ESVKSQMKQKDEDLERRLEQAEEK---HLKE 2137

Query: 591  HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL 650
             K  QE L D ++ +K HL          E ++ E+   LN+  ++V QL   + +    
Sbjct: 2138 KKNMQEKL-DALRREKVHL----------EETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186

Query: 651  LLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710
            L    AA T   + LQ+  D     + + ++   K +  +     +++ K+++CS L+  
Sbjct: 2187 L----AAFTKSMSSLQDDRD---RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239

Query: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770
            L++       +    EEL+  I +LE D  ++  SK Q   ++Q Q+++   L+    EL
Sbjct: 2240 LRQ-------MSIHMEELKINISRLEHDK-QIWESKAQT--EVQLQQKVCDTLQGENKEL 2289

Query: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
              QLE  + +  S++ +L K    L+S+K +LT           D     ++ K Q   L
Sbjct: 2290 LSQLEETRHLYHSSQNELAKLESELKSLKDQLT-----------DLSNSLEKCKEQKGNL 2338

Query: 831  NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890
               I+    ++Q  K   E L T+L   ++  S++ +       E   + QK  + +   
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHE-------EINMKEQKIISLLSGK 2391

Query: 891  EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN 950
            E+  +    +L+ Q +   KE KEL+  L +E+E +  L+ E     ++  Q   TLK  
Sbjct: 2392 EEAIQVAIAELRQQHD---KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI 2448

Query: 951  EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
            +KE  Q +  ++   +S    +   + + G+ +    Q  E    +  +  Q  QE AAE
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ----QLEERHLSIILEKDQLIQEAAAE 2504

Query: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI 1070
              K   L+      +     L S+    ++EL+  R+DL  V       Q+ L+  + Q 
Sbjct: 2505 NNK---LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ- 2560

Query: 1071 GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE 1130
              QNK   EL+   A LE+   + E+  ++  ++   +Q+EK    KE+ + K  ++++ 
Sbjct: 2561 --QNK---ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLT 2615

Query: 1131 EIKCRQEKEIT--------KLNEELKSHKLESI-----KEITNLKDAKQLLIQQKLELQG 1177
                  ++E T        K+ EE + H+L ++     K I  L++    + ++  +  G
Sbjct: 2616 RQVTALQEEGTLGLYHAQLKVKEE-EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG 2674

Query: 1178 K-ADSLKAAVEQEKRNQQILKDQVKKEEE---ELKKEFIEKEAKLHSEIKEKE---VGMK 1230
            +  D LK  ++    +  I++++ +  EE   EL ++ +E E KL    KE +     ++
Sbjct: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734

Query: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
                + + L       NE L  +K+++ +S + +++L++Q    R   A+L  T  +   
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS 2794

Query: 1291 ERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
                 L    K   ++     ++L L  +L+++   VQ   +   SLQ
Sbjct: 2795 TEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842



 Score =  206 bits (523), Expect = 2e-52
 Identities = 317/1506 (21%), Positives = 638/1506 (42%), Gaps = 228/1506 (15%)

Query: 6    LQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHD 65
            LQ+    + ++   L  S+  +  +   NE  S      +     G AD        V  
Sbjct: 473  LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532

Query: 66   AGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK 125
            A   S    ES   +  +  +   +E+  L   +KE +     LK +L   QG + +EA 
Sbjct: 533  ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL---QGKRAEEA- 588

Query: 126  PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
             D  V D        ++++++ + E     +MK   E           D     +EE SL
Sbjct: 589  -DHEVLD--------QKEMKQMEGEGIAPIKMKVFLEDTG-------QDFPLMPNEESSL 632

Query: 186  -----REAAEQKVTRLTEELNKEATVI------QDLKTELLQRPGI-----EDVAVLKKE 229
                  +A+ +  +R +EE++     +      QD    L   P I     +++  LK +
Sbjct: 633  PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692

Query: 230  LVQV-------QTLMDNMTLERERESEKLK---DECKKLQSQYASSEATISQLRSELAKG 279
            ++++       Q + +    E+ +E   L    +E KK     +S+   +S+ R +L   
Sbjct: 693  ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752

Query: 280  PQEVAVYVQ---ELQKLKSSVNE------LTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
             +E+++  +   ++++L+ ++ E      L  ++QT  +NLL ++     +E K  +  +
Sbjct: 753  VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI 812

Query: 331  -----SKKNIQATLHQKDLDCQQLQSRLSASETS-------LHRIHVELSEKGEATQKLK 378
                    ++Q    ++    + LQS+L   E+        +  I  ++ E  +A  + +
Sbjct: 813  EVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKE 872

Query: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438
             E+++++      K + + LQQ  EEK+Q   ++   + +   +L E +  LG     LK
Sbjct: 873  LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932

Query: 439  EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQLDKTKQQHQEQQ 494
            EQ  L S     K++QV +     S L++   E       +  ELQH+ D  K+++++++
Sbjct: 933  EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK 992

Query: 495  ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
                    KL+ A  + +++L+++   ++++ NL+    +SK+ I L E ER ++    +
Sbjct: 993  -------RKLQAALINRKELLQRVSRLEEELANLK---DESKKEIPLSETERGEVEEDKE 1042

Query: 555  AGE-GETAVLNQLQE----KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
              E  E  V ++ QE       T+ E+  +L + ++   E    A+E     V++    L
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVEL-QHIRKDLEEKLAAEEQFQALVKQMNQTL 1101

Query: 610  RAAQDRVLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ--RAD 664
            +   +++  L+  ++E   +  +L  S    S  D     K  +++S     +++  + +
Sbjct: 1102 QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161

Query: 665  LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ- 723
            L+  +   +   +  Q++L +  T    +  K Q+K+ H   L   LK+ K+ Y  L++ 
Sbjct: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH---LREELKQQKDDYNRLQEQ 1218

Query: 724  ------KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL-----RATELS- 771
                  + E +  Q+++L+   ++V+ S +  L    QQ   ++   L     +ATE   
Sbjct: 1219 FDEQSKENENIGDQLRQLQ---IQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275

Query: 772  ------------------------------------KQLEMEK-EI---VSSTRLDLQKK 791
                                                K++E EK E+   VSST  +L KK
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335

Query: 792  SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT-------------- 837
            SE +  +++++ KQ  E + LK    T+S E ++  E L  +++++              
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLK----TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ 1391

Query: 838  --VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
              + ELQK+  +KE    ++S +  +LS+   +L   ++E  ++    KA    LE   K
Sbjct: 1392 PKLDELQKLISKKE---EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448

Query: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
            E   +++ Q++  L E K+  + + +E  A  Q++ +L   Q  LI  +  LK+N+  ++
Sbjct: 1449 EHDERIK-QLQVELCEMKQKPEEIGEESRAKQQIQRKL---QAALISRKEALKENKSLQE 1504

Query: 956  QL---QGNINELKQSSEQKKKQIEALQGEL-----KIAVLQK------TELENKL--QQQ 999
            +L   +G I  L +S    + Q+ A   E      ++A+LQ+      TE++  L   Q 
Sbjct: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564

Query: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
            L+ + + L   K  +  L  + EK  +  + L+S      +E     ++L+   E L  +
Sbjct: 1565 LSSSCESL---KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS 1621

Query: 1060 QEDLISNRNQIGNQNKLI----QELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
             E++ +   +I +  + +    QEL     + E +  + E+QLQE   A Q++++ K   
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE---AEQEMEEMKEKM 1678

Query: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
             K   +++ K+ E+EE   R   E+    +  K      +    ++K+  + +  +   L
Sbjct: 1679 RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETL 1738

Query: 1176 QGKADSLKAAVEQEKRNQQILKDQVK-KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
              K  SL +  +      Q LK Q++    ++   E  EK     +  +E    +    E
Sbjct: 1739 SKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETE 1798

Query: 1235 NEAKLTM--------QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
             +  L+M         + +       V K++ SS   ++   +Q D L+  IA LE   Q
Sbjct: 1799 EQDSLSMSTRPTCSESVPSAKSANPAVSKDF-SSHDEINNYLQQIDQLKERIAGLEEEKQ 1857

Query: 1287 NN-------QDERRALLERCLKGEGEIEKLQTKVL-------ELQRKLDNTTAAVQELGR 1332
             N       ++E+  LL +    +GE++ LQ +V        ++Q +L   T   +    
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917

Query: 1333 ENQSLQ 1338
            E   L+
Sbjct: 1918 EKDDLE 1923



 Score =  194 bits (493), Expect = 5e-49
 Identities = 259/1306 (19%), Positives = 582/1306 (44%), Gaps = 143/1306 (10%)

Query: 75   ESNLALKRDDVT---LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
            +  L + +++VT   LL Q++Q+  + + + K  +EE K +LE  + L  Q A+ +G + 
Sbjct: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIG 1938

Query: 132  DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
            +   ++   + + E  ++E  N+K+     E++  QL  E   ++S+  +E   +    Q
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998

Query: 192  K-------VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK-----ELVQVQTLMDN 239
            K          L E L ++   ++ L+ + ++    E ++ L++     E VQ ++  D 
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKISALERTVKALEFVQTESQKD- 2055

Query: 240  MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV-N 298
            + + +E  ++ ++   KK Q++ AS +  +   +SE A+   +     +ELQ  K SV +
Sbjct: 2056 LEITKENLAQAVEHR-KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114

Query: 299  ELTQKNQTLTENLLKKEQDYTK----LEEK---------HNEESVSKKNIQATLHQKDLD 345
            ++ QK++ L   L + E+ + K    ++EK         H EE++ +  IQ TL++KD +
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE--IQVTLNKKDKE 2172

Query: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE- 404
             QQLQ  L ++ T L      +S   +   ++ +E  + E K+         +Q + EE 
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA------IQSKEEEI 2226

Query: 405  --KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
              KE +   L+ ++ Q+   + E +  +     RL+  +Q+   K   + Q    LQ K+
Sbjct: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINIS----RLEHDKQIWESKAQTEVQ----LQQKV 2278

Query: 463  -SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
               L+ + KE ++   E +H    ++ +  + ++  +S   +L +  N LE+   Q G+ 
Sbjct: 2279 CDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338

Query: 522  DQKIQNLEALLQKSKENISLLEKERE---DLYAKI--QAGEGETAVLNQLQEKNHTLQEQ 576
            +  I+  EA +Q SK +   LE + +   +L +++  +    E  +++ L  K   +Q  
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398

Query: 577  VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
            + +L    + Q +   +  ENL  Q +E+   L     + +       +  +QL E+ + 
Sbjct: 2399 IAEL----RQQHDKEIKELENLLSQEEEENIVLEEENKKAV-------DKTNQLMETLKT 2447

Query: 637  VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
            + + +IQ KA+ +  + + ++       LQN  D      Q  ++    I  + DQ+   
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSS-------LQNDRDRIVGDYQQLEERHLSIILEKDQL--- 2497

Query: 697  LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL--QDLQ 754
            +Q+     ++L       KE+   L    ++L  +  KL+A+ ++ +    Q +  +D Q
Sbjct: 2498 IQEAAAENNKL-------KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQ 2550

Query: 755  QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814
            Q++ L   L+      +K  ++E++        L++  EA E +++     +EEKQ L +
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEK--------LKESEEANEDLRRSFNALQEEKQDLSK 2602

Query: 815  DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
            + E+L    K+   +L  +    VT LQ+ +        +L   ++++ ++S    +S+ 
Sbjct: 2603 EIESL----KVSISQLTRQ----VTALQE-EGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653

Query: 875  EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
               +  ++      +  K   E++ +L+ ++++   +   ++   E  +E   +L  +L 
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713

Query: 935  SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
             M+++L+      K    + Q    +++ L+ S +   ++++ L+ +   ++ +  +L+ 
Sbjct: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK- 2772

Query: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL---ATRQDLKS 1051
              +Q L    ++    +   S + +  E S    ++L      ++ +LL   +  +D  +
Sbjct: 2773 --EQGLLNRERDALLSETAFS-MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829

Query: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111
              +  S A   L + R+ + N+ +  ++ +  K       +    ++Q   KA+  +Q +
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889

Query: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
            +    KEL N + +  +I +       EIT+L+  LK+   E   +    +  ++ L Q+
Sbjct: 2890 RDRLLKELKNLQQQYLQINQ-------EITELH-PLKAQLQEYQDKTKAFQIMQEELRQE 2941

Query: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQ----VKKEEEELK--KEFIEKEAKLHSEIKEK 1225
             L  Q +   L+      + +++ +K+Q    +  ++++L   +  I +     S+ +  
Sbjct: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001

Query: 1226 EVGMKKHEENEA--------KLTMQITALNENLGTVKKEWQSSQRRV-------SELEKQ 1270
            +V  ++    E          L  +   L   L    KE    + R+       S+L ++
Sbjct: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061

Query: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
             + L  ++     +++ NQ     LL  C   E ++++LQ   L +
Sbjct: 3062 KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107



 Score =  191 bits (486), Expect = 3e-48
 Identities = 304/1474 (20%), Positives = 602/1474 (40%), Gaps = 238/1474 (16%)

Query: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAEL-Q 138
            +K    T+L  E Q  +   K +K  +EE + E+EK +   Q++ +   L++   A+L Q
Sbjct: 114  MKAQGGTVLPTEPQSEEQLSKHDKSSTEE-EMEIEKIKHKLQEKEE---LISTLQAQLTQ 169

Query: 139  SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV----- 193
            +  +Q  ++ TE      MK   ++K   ++T  A +     E+ + +   E+       
Sbjct: 170  AQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ 229

Query: 194  TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL----------VQVQTLMDNMTLE 243
             RL E+   +     D++TE+ Q+     + VL+++L           QV  L+      
Sbjct: 230  VRLHEDELLQLVTQADVETEMQQK-----LRVLQRKLEEHEESLVGRAQVVDLLQQELTA 284

Query: 244  RERESEKLKDECKKLQSQYASSEATISQLRSE----LAKGPQEVAVYVQELQKLKSSVNE 299
             E+ ++ L  + +++++++ +   T+   R E    L K   EVA        L+  ++ 
Sbjct: 285  AEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH 344

Query: 300  LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
            L ++ +   +   + E  Y+ LE+KH  E   K +   +L +     Q+LQS   A +  
Sbjct: 345  LLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTG---QELQSACDALKDQ 401

Query: 360  LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ-----QQREEKEQ------- 407
              ++   L +K E   +  + + ++E + Q    E  Q       QQ E   Q       
Sbjct: 402  NSKL---LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVY 458

Query: 408  -HGLQLQSEIN--QLHSKLLETERQLG-------EAHGRLKEQRQLSSE-KLMDKEQQVA 456
              G Q  +E N   L  +++E E + G       E      E  +LSS+  L++ + +  
Sbjct: 459  NEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTG 518

Query: 457  DLQLKLSRLE-EQLKEKVTNSTELQHQ--LDKT-KQQHQE--------QQALQQSTTAKL 504
            +   ++S +    +  K ++S E   Q  L+ T  Q+H+E        ++A ++    KL
Sbjct: 519  EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578

Query: 505  REAQNDLEQVLRQIGDKDQKIQ---------NLEALLQKSKENISLLEKEREDLYA---- 551
            +      E+   ++ D+ +  Q          ++  L+ + ++  L+  E   L A    
Sbjct: 579  QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638

Query: 552  ----KIQAGEGETAVLNQL-------------------------QEKNHTLQEQVTQLTE 582
                + Q+   E   LN                           Q++   L+ Q+ +L  
Sbjct: 639  QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELEL 698

Query: 583  KL--------KNQSESHKQAQENLHDQVQEQKAH----------LRAAQDRVLS------ 618
                      KN  E  K+   NL+  ++E K +          L   +D++LS      
Sbjct: 699  NFHKAQEIYEKNLDEKAKEIS-NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757

Query: 619  ----LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN-HLDTAQ 673
                L   V +L   L E+ E+  +LD + +   + LL+ +    +  A  ++  ++  Q
Sbjct: 758  MVTELRAQVKQLEMNLAEA-ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816

Query: 674  NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
            N L D Q + ++ +T +  + ++LQ+K+    +    ++    K   L Q   + E +I 
Sbjct: 817  NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEIT 876

Query: 734  KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI----VSSTRLDLQ 789
            K++   LE K   E   Q ++++ Q  T++    TE   QL  EK      + + +  L 
Sbjct: 877  KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLN 936

Query: 790  KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
              S A E+ K+++ +  E    LKQ+++ +S   +I  EEL +       E ++ K + +
Sbjct: 937  LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ 996

Query: 850  A--------------LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
            A              L  EL+ +KD+  K     +  + E E++ +  + +   +   C+
Sbjct: 997  AALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQ 1056

Query: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
            E++  L+  +     E + ++K LE++  A  Q +  +  M + L    N +   + E  
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116

Query: 956  QLQGNINEL--------------------------KQSSEQKKKQIEALQGELKIAVL-- 987
            + Q  I +L                            SSE  K ++E      KI  L  
Sbjct: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEE-----KILALEK 1171

Query: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF--YGRESELLAT 1045
            +K +L+ KLQ+ LT     L   +EK   L+   ++ ++ + +LQ  F    +E+E +  
Sbjct: 1172 EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231

Query: 1046 R------QDLKSVEEKL-SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
            +      Q  +S++ KL S  Q++  S+   +        E    +  LE +        
Sbjct: 1232 QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH 1291

Query: 1099 QERCKALQ------DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH-- 1150
             E   ALQ       I+ +    E E V  + K++       ++ +E+ +L E++     
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351

Query: 1151 KLESIKEITNLKDAKQLLIQQKL--------------ELQGKADSLKAAVEQEKRNQQIL 1196
            ++ES+K +++  +     +QQKL              ELQ K D L+  + +++ +   L
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411

Query: 1197 KDQVKKEEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALN---ENL 1250
              Q+ ++E  L K   E IE+E  + +   + E+  K+H+E   +L +++  +    E +
Sbjct: 1412 SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI 1471

Query: 1251 GTVKKEWQSSQRRV-------SELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
            G   +  Q  QR++        E  K+   L+ E+++   T++        +  +     
Sbjct: 1472 GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQN 1531

Query: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
             E + +  ++  LQ + D     +     ENQSL
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565



 Score =  174 bits (441), Expect = 5e-43
 Identities = 274/1255 (21%), Positives = 516/1255 (41%), Gaps = 220/1255 (17%)

Query: 291  QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
            Q+     N  TQ++  + E L   EQ   +L++      + +K++Q  L QKD   + LQ
Sbjct: 36   QESDMEFNNTTQED--VQERLAYAEQLVVELKD-----IIRQKDVQ--LQQKD---EALQ 83

Query: 351  SRLSASETSLHRIHVELSEKGEATQKLKEEL---------SEVETKYQHLKAEFKQLQQQ 401
                A++  + ++ +    K  +  K  EE+         +E +++ Q  K +    +++
Sbjct: 84   EERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEE 143

Query: 402  RE-EKEQHGLQLQSE-INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
             E EK +H LQ + E I+ L ++L + + +         E+  +  ++L +KE+ ++ LQ
Sbjct: 144  MEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ 203

Query: 460  LKLSRLE-EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA--------KLREAQND 510
             +LS+ + EQ  ++V    + + +   T+ +  E + LQ  T A        KLR  Q  
Sbjct: 204  AQLSQTQAEQAAQQVVREKDARFE---TQVRLHEDELLQLVTQADVETEMQQKLRVLQRK 260

Query: 511  LEQVLRQIGDKDQKI----QNLEALLQKSK---ENISLLEKEREDLYAKIQAGEGETAVL 563
            LE+    +  + Q +    Q L A  Q+++   + +  +E E   L   ++    E+ +L
Sbjct: 261  LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL 320

Query: 564  NQLQEKN--------HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             +  E          H LQE++  L E+ +   ++  + +       Q+ KA +      
Sbjct: 321  LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380

Query: 616  VLSLETSVNEL------------------NSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
            +LSL+ +  EL                  N Q  +S + + QL+ Q++ K     S E +
Sbjct: 381  ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK-----SKEIS 435

Query: 658  KTAQRADLQNHLDTAQNALQDKQQELNKITTQ-----LDQVTAKLQDKQEHCSQLESHLK 712
            +   R  LQ H   +Q +  D   E  +  T+     L +   +L++++         L+
Sbjct: 436  QFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE 495

Query: 713  EYKEKYLSLEQKTEELEGQIKKLEAD------SLEVKASKEQALQDLQQQRQLNTDLELR 766
            E K +   L  +   LE Q +  EAD      S+   A+K  +  +   Q  L      +
Sbjct: 496  ELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQK 555

Query: 767  ATELSKQL-EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
              ELS  L EM++       L LQ + +  E    ++  Q+E KQ+  +    +  +  +
Sbjct: 556  HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFL 615

Query: 826  QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
            +    +  +     E     +EKE   TE  +   +   ++D+    KS  +++  K  +
Sbjct: 616  EDTGQDFPLMPN-EESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKST-KQDGDKSLS 673

Query: 886  AILDL----EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
            A+ D+    +   + LK Q+     N  K Q+  +K+L+++ +    L   +   ++   
Sbjct: 674  AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733

Query: 942  QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK-------TELEN 994
               +      +E  QL   + EL   +E +  Q++ L+  L  A  Q+       T  +N
Sbjct: 734  NNSSAFTALSEERDQLLSQVKELSMVTELRA-QVKQLEMNLAEAERQRRLDYESQTAHDN 792

Query: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ-------LQSDFYGRESELLATRQ 1047
             L +Q+   + E  ++  KI VLQN  +  Q  F +       LQS    +ESE+L   +
Sbjct: 793  LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852

Query: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE----RCK 1103
             ++ +  K+    + L     +I   ++L+ E K    TL+Q   +K+QQ+ E      +
Sbjct: 853  RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE 912

Query: 1104 ALQDIQKEK---SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160
             +  + +EK    ++ K L  + + L+  EE K  Q +E  +++  LK +  E       
Sbjct: 913  KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE------- 965

Query: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI---------------------LKDQ 1199
            +  A Q+    K ELQ + D LK   EQ KR  Q                      LKD+
Sbjct: 966  MSPAGQI---SKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022

Query: 1200 VKKE------------EEELKKEFIEK---------EAKLHSEIKEKEVGMKK-HEENEA 1237
             KKE            E++  KE+ EK         E  L   I EKEV ++   ++ E 
Sbjct: 1023 SKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082

Query: 1238 KLTMQ------ITALNENLGTVKKEWQSSQRRVSE--------LEKQTDDLRGE-IAVLE 1282
            KL  +      +  +N+ L     +    Q  +SE        +   TD   G+ +A+++
Sbjct: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142

Query: 1283 ATVQ-------NNQDERRALLERCLKGEGEIEKLQTKVLE-------------------- 1315
             TV        +++  +  L E+ L  E E E+LQ K+ E                    
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202

Query: 1316 ------------LQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNC 1358
                        LQ + D  +   + +G + + LQI+  ++++ K    ++ ++C
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257



 Score =  171 bits (433), Expect = 5e-42
 Identities = 247/1190 (20%), Positives = 511/1190 (42%), Gaps = 193/1190 (16%)

Query: 89   RQEVQDLQASLKEEKWYSEELKKELEKYQ----GLQQQEAKPDGLVTDSSAELQ----SL 140
            +   ++LQ  LKE++   ++L+K+  +YQ     L++     + + T+S  +L+    +L
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063

Query: 141  EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
             Q +E  +     +   K L +   ++ A  +AD      E +S +E+ + ++ +  E+L
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL 2123

Query: 201  NKEATVIQDLKTELLQRPGIED-VAVLKKELVQVQTLMDNMTL---ERERESEKLKDECK 256
              E  + Q  +  L ++  +++ +  L++E V ++  +  + +   ++++E ++L++   
Sbjct: 2124 --ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181

Query: 257  KLQSQYASSEATISQLRSE------------------LAKGPQEVAVYVQELQKLKSSVN 298
               +Q A+   ++S L+ +                  +    +E+ +       LK  + 
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2241

Query: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH--QKDLDCQ--------- 347
            +++   + L  N+ + E D    E K   E   ++ +  TL    K+L  Q         
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH 2301

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEE-------LSEVETKYQHLKAEFKQLQQ 400
              Q+ L+  E+ L  +  +L++   + +K KE+       + + E   Q+ K  ++QL+ 
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361

Query: 401  QREEKEQHGLQLQSEINQLHSKLLETERQLGEA-HGRLKEQRQLSSEKLMDKEQQVADLQ 459
              +   +   +L  EIN    K++       EA    + E RQ   +++ + E  ++  +
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421

Query: 460  LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV----- 514
             +   LEE+ K+ V  + +L   L   K+++ +Q+A   S    +   QND +++     
Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481

Query: 515  ------LRQIGDKDQKIQNLEALLQKSKENISLLEKE------------------REDLY 550
                  L  I +KDQ IQ   A   K KE I  L                     REDL 
Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541

Query: 551  AKIQAGEGETAVLNQLQ-EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
              I   + +   L ++Q ++N  L+ +  +L EKLK   E+++  + + +  +QE+K  L
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN-ALQEEKQDL 2600

Query: 610  RAAQDRVLSLETSVNELNSQLNESKEK--VSQLDIQIKAKTELL--LSAEAAKTAQR-AD 664
                  + SL+ S+++L  Q+   +E+  +     Q+K K E +  LSA  + + +R A+
Sbjct: 2601 ---SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657

Query: 665  LQNHLDTAQNA-------LQDK-QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
            L+  L   Q         ++DK ++EL  +      +  + +  +E  ++L   L E ++
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717

Query: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLE 775
            K L + ++ + L  QI+        ++ S++ A ++L + +R+ +  L+  A +L +Q  
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA-QLKEQGL 2776

Query: 776  MEKE---IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
            + +E   ++S T   +    E   S  +KL +Q     +L +D + L   +++  E+  N
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQ-----LLSKDEQLLHLSSQL--EDSYN 2829

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVK--------------------DKLSKVSDSLKNS 872
            ++Q+    +  ++ E++ L  EL   +                      L K   SL+N 
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889

Query: 873  KSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQMENTLK---EQKELKKSLEKEKEAS 926
            +    KE +  +   L + +   EL   K QLQ   + T      Q+EL++     +   
Sbjct: 2890 RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949

Query: 927  HQLKLELNSMQ--EQLIQAQNTLKQNEKEEQ--QLQGNINELKQSSEQKKK--------- 973
            HQL++E +S +  E+ ++ Q  +  ++K++Q   LQ  I EL+ SS Q +          
Sbjct: 2950 HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQA 3009

Query: 974  ----------------QIEAL------------QGELKIAVL-----QKTELENKLQQQL 1000
                            + E L            Q EL+I  L     Q  E +N L  QL
Sbjct: 3010 SPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQL 3069

Query: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ-----------DL 1049
               +Q L   ++    L N+    ++  ++LQ+     +    A ++           +L
Sbjct: 3070 CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEEL 3129

Query: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
            +  ++  S AQ+ L + R ++    KL++E +  +   E   +  E+Q++
Sbjct: 3130 REPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179



 Score =  150 bits (378), Expect = 1e-35
 Identities = 244/1135 (21%), Positives = 502/1135 (44%), Gaps = 172/1135 (15%)

Query: 351  SRLSA-SETSLHRIHVELSEKGEATQKLKEELS---EVETKYQHLKAEFKQLQQQREEKE 406
            SRLS  +   LH    ELS   +  Q ++  L      E+  +      + +Q++    E
Sbjct: 3    SRLSGLANVVLH----ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAE 58

Query: 407  QHGLQLQSEINQLHSKLLETERQLGE----AHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
            Q  ++L+  I Q   +L + +  L E    A  ++K+ +  +  KL    + + +++ + 
Sbjct: 59   QLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQG 118

Query: 463  SRL-------EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ------- 508
              +       EEQL +   +STE + +++K K + QE++ L  +  A+L +AQ       
Sbjct: 119  GTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQS 178

Query: 509  -NDLEQVL---RQIGDKDQKIQNLEALLQKSKENISLLEKERE-DLYAKIQAGEGETAVL 563
              ++E+ +   +Q+ +K++ I  L+A L +++   +  +  RE D   + Q    E  +L
Sbjct: 179  STEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELL 238

Query: 564  NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
              + + +  ++ ++ Q    L+ + E H+++       V   +  L AA+ R   L   +
Sbjct: 239  QLVTQAD--VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296

Query: 624  NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
             ++ ++ N  +  V       + ++++LL     + A+R          + +  + Q+E+
Sbjct: 297  QQMEAEHNTLRNTVE----TEREESKILLEKMELEVAER----------KLSFHNLQEEM 342

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLE-SHLKEYKEK---YLSLEQKTEELEGQIKKLEADS 739
            + +  Q +Q      + +   S LE  H  E +EK    LSL++  +EL+     L+  +
Sbjct: 343  HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402

Query: 740  LEVKASK-EQALQDLQQQRQLNTDLELRATELSKQLE----MEKEIVSSTRL-DLQKK-- 791
             ++   K EQA+Q  Q  +QL   L+ ++ E+S+ L      + E  S T   D+  +  
Sbjct: 403  SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462

Query: 792  ----SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
                 E + S+++++ + E EK  L      L +E K ++E+L+++I  T+ E Q    E
Sbjct: 463  QAVTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQI--TLLEAQNRTGE 519

Query: 848  KEALMTELSTVKDKLSKVSDSLKNS-----KSEFEKENQKGKAAILDLEKTCKE---LKH 899
             +  ++E+S V D  +K S S + S     ++ F +++++    +L++++  +E   LK 
Sbjct: 520  ADREVSEISIV-DIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578

Query: 900  QLQ----VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE---------------QL 940
            QLQ     + ++ + +QKE+K+ +E E  A  ++K+ L    +               + 
Sbjct: 579  QLQGKRAEEADHEVLDQKEMKQ-MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637

Query: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL-------QGELKIAVLQKTELE 993
             QA    +    EE  L     ELK + +   K + A+       Q EL+    Q  ELE
Sbjct: 638  EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697

Query: 994  ---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
               +K Q+   +   E A E   ++ L   ++K+ +      +       +LL+  ++L 
Sbjct: 698  LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757

Query: 1051 SVEE--------KLSLAQED---LISNRNQIGNQNKLIQELKTAKATLEQDSAKKE---- 1095
             V E        +++LA+ +    +   +Q  + N L +++ +     +    K E    
Sbjct: 758  MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQN 817

Query: 1096 ------QQLQERCKALQDIQKEKSLKEKELV-------NEKSKLAEIEEIKCRQEKEITK 1142
                   Q  E+   ++ +Q +   KE E++       +  SK+ E+ +   ++E EITK
Sbjct: 818  ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK 877

Query: 1143 LNEEL--KSHKLESIKEITNLKDAKQL------------LIQQKLELQGKADSLKAAVEQ 1188
            +++ L  K   +E++++    KD +              L ++K  L  +  +LK  +  
Sbjct: 878  MDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL 937

Query: 1189 EKRNQQILKDQVKKEEE---ELKKEFIEKE--AKLHSEIKEKEVGMKKHEENEAKLTMQI 1243
              R ++  K+QV+++ E    LK+ + E     ++  E  + E  + K E  + K  +Q 
Sbjct: 938  LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA 997

Query: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV-------LEATVQNNQDERRALL 1296
              +N      K+  Q   R   EL    D+ + EI +       +E   +N +   + + 
Sbjct: 998  ALINR-----KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVT 1052

Query: 1297 ERCLKGEGEIEK-LQTKVLELQ---RKLDNTTAAVQE----LGRENQSLQIKHTQ 1343
             +C + E  +++ +  K +ELQ   + L+   AA ++    + + NQ+LQ K  Q
Sbjct: 1053 SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1107



 Score =  148 bits (373), Expect = 4e-35
 Identities = 209/1016 (20%), Positives = 438/1016 (43%), Gaps = 137/1016 (13%)

Query: 68   NDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPD 127
            +D+    E  + LK D+ ++L+ +++ +   ++E K     L+ + + ++   Q E +  
Sbjct: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2275

Query: 128  GLVTDS-----------------------------SAELQSLEQQLEEAQTENFNIKQMK 158
              V D+                              +EL+SL+ QL +        K+ K
Sbjct: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335

Query: 159  DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN-KEATVIQDL--KTELL 215
               E    Q   +I + K  Y++  +  +A+ +  +RL EE+N KE  +I  L  K E +
Sbjct: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395

Query: 216  QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
            Q      +A L+++  +    ++N+  + E E+  L++E KK   +      T+  ++ E
Sbjct: 2396 QVA----IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451

Query: 276  LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN----LLKKEQDYTKLEEKHNEESVS 331
              +   ++  +V+ +  L++  + +    Q L E     +L+K+Q   +   ++N+    
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511

Query: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRI------------HVELSEKGEATQK--- 376
             + +++ +   + +  +L + L      L+++             V+L +  E   K   
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571

Query: 377  LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL--LETERQLGEAH 434
            L+E+L E E   + L+  F  LQ+++++  +    L+  I+QL  ++  L+ E  LG  H
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631

Query: 435  GRLK---EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT-KQQH 490
             +LK   E+    S      ++++A+L+ +L  ++++  +KV    E++ +L K  K  H
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG---EIEDKLKKELKHLH 2688

Query: 491  QEQQALQQST-TAKLREAQ--NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
             +   ++  T TA+ R A+   DL ++ +++    ++ + L A +Q    ++S L+  R+
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748

Query: 548  -------DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
                   +L  K  A   E A L +    N      +++    + +  E+     E L+ 
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808

Query: 601  QV---QEQKAHLRAA-QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
            Q+    EQ  HL +  +D    +++    + S  NE     ++L+   K++     SA  
Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ 2868

Query: 657  AKTAQR---------ADLQNHLDTAQNALQDKQQE---LNKITTQLDQVTAKLQDKQEHC 704
              T+           + LQN  D     L++ QQ+   +N+  T+L  + A+LQ+ Q+  
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928

Query: 705  SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV--KASKEQALQDLQQQRQLNTD 762
               +   +E +++ LS + +  +L     ++E  S E+  +  KEQ L  +  + Q    
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQL-----RMEKSSWEIHERRMKEQYLMAISDKDQ---- 2979

Query: 763  LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD-FETLSQ 821
                  +LS    + +E+ SS        S   + +K +  +Q   +     D  + L  
Sbjct: 2980 ------QLSHLQNLIRELRSS--------SSQTQPLKVQYQRQASPETSASPDGSQNLVY 3025

Query: 822  ETKIQHEELNN---RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
            ET++   +LN+    I      +Q++      L+ E +T+  +L   S SL+ ++  +  
Sbjct: 3026 ETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG- 3084

Query: 879  ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
                      DL   C  L+ Q+Q      L    ++     +EK   H+      S  E
Sbjct: 3085 ----------DLLNHCAVLEKQVQELQAGPL--NIDVAPGAPQEKNGVHR-----KSDPE 3127

Query: 939  QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
            +L + Q +  + +++    +  +NEL++  E+++ Q  A +  L +A  Q   LE+
Sbjct: 3128 ELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3183


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  213 bits (541), Expect = 1e-54
 Identities = 224/1110 (20%), Positives = 481/1110 (43%), Gaps = 93/1110 (8%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E   IK +  +  + R+  E+K+  L +E N     +Q     L      E
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE--E 909

Query: 222  DVAVLKKELVQVQTLMDNMTLERERESE----------KLKDECKKLQSQYASSEATISQ 271
                L K  +Q++  +  +T   E E E          KL+DEC +L+      E T+++
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +  E      +V    +E+  L  ++ +LT++ + L E   +   D    E+K N  + +
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029

Query: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
            K  ++  +   +   +Q +      E +  ++  +L    E+   ++ E  +++ K +  
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL-GEAHGRLKEQRQLSSEKLMD 450
            + E   LQ + E+++  G+QLQ +I +L +++ E E ++  E   R K ++Q S     D
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS-----D 1144

Query: 451  KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
              +++ ++  +L         ++  + + + +  K ++  +E     ++T A LR+   D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 511  LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
                   + +  ++I NL+ + QK ++  S ++ E +DL + +   E  +     L++  
Sbjct: 1205 ------SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV---ETVSKAKGNLEKMC 1255

Query: 571  HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
             TL++Q+++L        +S ++ Q+ L + +  Q+  L+               L SQL
Sbjct: 1256 RTLEDQLSEL--------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307

Query: 631  NESKEKVS--------QLDIQIKAKTELLLSAEAAKTAQRAD-LQNHLDTAQNALQDKQQ 681
            +  K+  +        QL+ +IKAK  L  + ++++     D L+   +  Q +  + Q+
Sbjct: 1308 SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR--HDCDLLREQYEEEQESKAELQR 1365

Query: 682  ELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
             L+K  T++ Q   K + D  +   +LE   K+  ++  + E+  E +  +   LE    
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425

Query: 741  EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
             ++   E  + D+++       L+ +     K L   K+    T  +L+   +   S+  
Sbjct: 1426 RLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGT 1485

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ------TTVTELQKVKMEKEALMTE 854
            +L K +   +      ETL +E K   +E+++  +        + EL+K+K + E    E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 855  LSTV-----------KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
            L              + K+ ++   L   KSE +++  +    I  L++    +   +Q 
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605

Query: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
             ++  ++ + +  +  +K +   ++++++LN       +A    +  +   +  Q ++++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665

Query: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ---AAQELAAEKEKISVLQNN 1020
              +S E  K+Q+  ++    +   +  EL   L+Q       A QEL    E++ +L   
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
                  T K+L++D    + E+    Q+ ++ EEK   A  D      ++  +      L
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK--EKELVNEKSKLAEIEEIKCRQEK 1138
            +  K  +EQ    K+ QL+       D  ++ +LK  +K++   ++++ E+E     ++K
Sbjct: 1786 ERMKKNMEQ--TVKDLQLR------LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837

Query: 1139 EITKLNEELKSHKLESIKEIT--NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
               +  + L+ H+   +KE+T    +D K +     L LQ   D L+A V+  KR  +  
Sbjct: 1838 RNAEAVKGLRKHE-RRVKELTYQTEEDRKNI-----LRLQDLVDKLQAKVKSYKRQAE-- 1889

Query: 1197 KDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
                  E EE     + K  KL  E++E E
Sbjct: 1890 ------EAEEQSNTNLAKFRKLQHELEEAE 1913



 Score =  202 bits (514), Expect = 2e-51
 Identities = 235/1150 (20%), Positives = 496/1150 (43%), Gaps = 134/1150 (11%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E+E   +K+E +K++ + A SEA   +L  ++    +E      ++Q     + +  +
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            +   L +  ++ E    ++ E+  +E      + A   + + +C +L+  +   E +L +
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EE++ ++     L  E K LQ+  ++        + ++N L   
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029

Query: 423  LLETERQLGEAHGRLKEQRQLSSE----------KLMDKEQQVADLQLKLSRLEEQLKEK 472
             ++ E+Q+ +  G L+++++L  +           L   ++ + D++ +  +L+E+LK+K
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
                + LQ ++       +++QAL      K++E Q  +E++       +++I+   A  
Sbjct: 1090 EFEISNLQSKI-------EDEQALGIQLQKKIKELQARIEEL-------EEEIEAERASR 1135

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH-------------TLQEQVTQ 579
             K+++  S L +E E++  +++   G T+   ++ +K               TLQ + T 
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 580  LTEKLKNQSESHKQAQ-----ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
             T + K+     +  +     + +  +++++K+ ++   D + S   +V++    L +  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 635  EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-------------- 680
              +     ++K+K E         TAQR  LQ         L +K+              
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 681  QELNKITTQL-DQVTAK------LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI- 732
            Q++ ++  QL +++ AK      LQ  +  C  L    +E +E    L++   +   ++ 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 733  ---KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
                K E D+++     E+A + L Q+ Q   +           LE  K+ + +   DL 
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 790  KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
               E   +    L K++     +  +++   +ET  + E      ++  TEL K+K   E
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495

Query: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQME 906
              + +L T+K    + + +L+   S+  ++  +G   I +LEK  K++   K +LQ  +E
Sbjct: 1496 ESLDQLETLK----RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551

Query: 907  NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
                   E + SLE E+    +++LELN ++ ++ +     K  EK+E        E+ Q
Sbjct: 1552 -------EAEASLEHEEGKILRIQLELNQVKSEVDR-----KIAEKDE--------EIDQ 1591

Query: 967  SSEQKKKQIEALQGELKIAVLQKTE---LENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
                  + +E++Q  L   +  + +   L+ K++  L +   +L       +    NY  
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651

Query: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
            +Q   K  Q        + L +++DLK   E+L++ +             N L  E++  
Sbjct: 1652 TQGILKDTQIHL----DDALRSQEDLK---EQLAMVER----------RANLLQAEIEEL 1694

Query: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
            +ATLEQ    ++   QE   A + +Q   + +   L+N K KL   E    + + E+  +
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHT-QNTSLINTKKKL---ETDISQMQGEMEDI 1750

Query: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV- 1200
             +E ++ + ++ K IT   DA  +  + K E    A  + +K  +EQ  ++ Q+  D+  
Sbjct: 1751 LQEARNAEEKAKKAIT---DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1807

Query: 1201 -------KKEEEELKKEFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENL 1250
                   KK+ ++L+    E E ++ SE K   E   G++KHE    +LT Q     +N+
Sbjct: 1808 QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867

Query: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
              ++      Q +V   ++Q ++   +     A  +  Q E     ER    E ++ KL+
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927

Query: 1311 TKVLELQRKL 1320
             K  E+  K+
Sbjct: 1928 VKSREVHTKV 1937



 Score =  174 bits (442), Expect = 4e-43
 Identities = 225/1014 (22%), Positives = 444/1014 (43%), Gaps = 154/1014 (15%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKPDGLVTDSSAELQSLEQQL 144
            L Q+V DL+ SL++EK    +L++   K +G   L Q+       + D   E Q L+++L
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES------IMDIENEKQQLDEKL 1086

Query: 145  EEAQTENFNIKQMKD-------LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
            ++ + E  N++   +         ++K  +L   I +++ + + ER+ R  AE++ + L+
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 198  EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257
             EL                    E+++   +E     +    M  +RE E +K++ + ++
Sbjct: 1147 REL--------------------EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 258  LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
               Q+   EAT + LR + A    E+   +  LQ++K                 L+KE+ 
Sbjct: 1187 ATLQH---EATAATLRKKHADSVAELGEQIDNLQRVKQK---------------LEKEKS 1228

Query: 318  YTKLE---EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
              K+E      N E+VSK   +  L +    C+ L+ +LS           EL  K E  
Sbjct: 1229 EMKMEIDDLASNVETVSK--AKGNLEKM---CRTLEDQLS-----------ELKSKEEEQ 1272

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
            Q+L  +L+    + Q    EF    +Q +EKE    QL         ++ E +RQL E  
Sbjct: 1273 QRLINDLTAQRGRLQTESGEF---SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE-- 1327

Query: 435  GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ----- 489
              +K +  L+    +   +   DL      L EQ +E+  +  ELQ  L K   +     
Sbjct: 1328 -EIKAKNALA--HALQSSRHDCDL------LREQYEEEQESKAELQRALSKANTEVAQWR 1378

Query: 490  -HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
               E  A+Q+  T +L EA+  L Q L+   +  + +    A L+K+K+    L+ E ED
Sbjct: 1379 TKYETDAIQR--TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---LQNEVED 1433

Query: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE-SHKQAQE------NLHDQ 601
            L   ++      A L++ Q     +  +  Q  E+   + E S K+A+        + + 
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
             +E    L   +    +L+  +++L  Q+ E  +++ +L+ +IK + E           +
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVE----------QE 1542

Query: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTA----KLQDKQEHCSQLE-SHLKEYKE 716
            + +LQ  L+ A+ +L+ ++ ++ +I  +L+QV +    K+ +K E   QL+ +H++    
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR---- 1598

Query: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
                +E     L+ +I+    D++ +K   E  L ++  + QLN      A E  +    
Sbjct: 1599 ---IVESMQSTLDAEIRS-RNDAIRLKKKMEGDLNEM--EIQLN-HANRMAAEALRNYRN 1651

Query: 777  EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL-------SQETKIQHEE 829
             + I+  T++ L     + E +K++L   E    +L+ + E L        +  KI  +E
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711

Query: 830  L---NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
            L   + R+Q   T+   +   K+ L T++S ++ ++  +    +N++       +K K A
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE-------EKAKKA 1764

Query: 887  ILDLEKTCKELKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
            I D     +ELK +      +E   K  ++  K L+   + + QL L+    Q Q ++A+
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEAR 1824

Query: 945  NTLKQNEKEEQQLQGNINELK--QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
                + E E +Q + N   +K  +  E++ K++     E +  +L+  +L +KLQ ++  
Sbjct: 1825 VRELEGEVESEQ-KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
              ++    +E+ +     + K Q   ++ +      ES++   R   + V  K+
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937



 Score =  156 bits (394), Expect = 2e-37
 Identities = 202/930 (21%), Positives = 397/930 (42%), Gaps = 104/930 (11%)

Query: 84   DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
            D+ L ++ + D++    E++   E+LKK+  +   LQ +      L      +++ L+ +
Sbjct: 1064 DLKLAQESIMDIE---NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE----------RSLREAAEQKV 193
            +EE + E    +  +   E++ + L+ E+ +I  + +E              REA  QK+
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180

Query: 194  TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
             R  E    EAT+  +     L++   + VA L +++  +Q +        +++ EK K 
Sbjct: 1181 RRDLE----EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKS 1228

Query: 254  ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS----VNELT-QKNQTLT 308
            E K      AS+  T+S+ +  L K  + +   + EL+  +      +N+LT Q+ +  T
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288

Query: 309  ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-- 366
            E+     +   +L+EK    S   +  QA   Q +   +QL+  + A     H +     
Sbjct: 1289 ES----GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 367  ----LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                L E+ E  Q+ K EL    +K         ++ Q R + E   +Q   E+ +   K
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKAN------TEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQH 481
            L +   Q  E H      +  S EK   + + +V DL L + R                 
Sbjct: 1399 LAQ-RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 482  QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
             L + KQ+ +E       T A+L  +Q +     R +G +  KI+N     ++S + +  
Sbjct: 1458 ILAEWKQKCEE-------THAELEASQKE----ARSLGTELFKIKN---AYEESLDQLET 1503

Query: 542  LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
            L++E ++L  +I      + +  Q+ E    + E      EK+K Q E  K     L   
Sbjct: 1504 LKRENKNLQQEI------SDLTEQIAEGGKRIHE-----LEKIKKQVEQEKC---ELQAA 1549

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLN----ESKEKVSQL---DIQIKAKTELLLSA 654
            ++E +A L   + ++L ++  +N++ S+++    E  E++ QL    I+I    +  L A
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ----LDQVTAKLQDKQEHCSQLESH 710
            E         L+  ++   N ++ +    N++  +           L+D Q H       
Sbjct: 1610 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK---EQALQDLQQQRQLNTDLELRA 767
             ++ KE+   +E++   L+ +I++L A   + + S+   EQ L D  ++ QL        
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 768  TELSKQLEMEKEIVSSTRLD-LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
                K+LE +   +     D LQ+   A E  K+ +T      + LK++     Q+T   
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE-----QDTSAH 1784

Query: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
             E +   ++ TV +LQ    E E L   L   K ++ K+   ++  + E E E ++   A
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842

Query: 887  ILDL---EKTCKELKHQLQVQMENTLKEQ---KELKKSLEKEKEASHQLKLELNSMQEQL 940
            +  L   E+  KEL +Q +   +N L+ Q    +L+  ++  K  + + + + N+   + 
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF 1902

Query: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
             + Q+ L++ E+     +  +N+L+  S +
Sbjct: 1903 RKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score =  123 bits (308), Expect = 1e-27
 Identities = 149/725 (20%), Positives = 307/725 (42%), Gaps = 86/725 (11%)

Query: 630  LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
            + E  +K+     + +AK + L         ++ DLQ  +      L D ++  +++   
Sbjct: 858  MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917

Query: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
              Q+ AK+++  E     E    E   K   LE +  EL+  I  LE    +V+  K   
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977

Query: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
               ++   +    L+    +L+K+ +  +E    T  DLQ + + + ++ +   K E++ 
Sbjct: 978  ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1037

Query: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQ-KVKMEKEALM---TELSTVKDKLSKV 865
              L+   E        Q ++L   ++    +L+  +K+ +E++M    E   + +KL K 
Sbjct: 1038 DDLEGSLE--------QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
               + N +S+ E E   G    + L+K  KEL+ +++ ++E  ++ ++  +   EK++  
Sbjct: 1090 EFEISNLQSKIEDEQALG----IQLQKKIKELQARIE-ELEEEIEAERASRAKAEKQRS- 1143

Query: 926  SHQLKLELNSMQEQLIQAQNT----LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
               L  EL  + E+L +A       ++ N+K E + Q    +L++++ Q +     L+ +
Sbjct: 1144 --DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 982  LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
               +V +  E  + LQ+   +  +E +  K +I  L +N E   +    L+      E +
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
            L     +LKS EE+                 Q +LI +L   +  L+ +S +  +QL E+
Sbjct: 1262 L----SELKSKEEE-----------------QQRLINDLTAQRGRLQTESGEFSRQLDEK 1300

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
               +  + + K          ++   +IEE+K + E+EI   N    +H L+S +   +L
Sbjct: 1301 EALVSQLSRGK----------QAFTQQIEELKRQLEEEIKAKNA--LAHALQSSRHDCDL 1348

Query: 1162 -KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
             ++  +   + K ELQ         V Q +   +    Q  +E EE KK+  ++      
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------ 1402

Query: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
                    ++  EE+       + A+N    +++K  Q  Q  V +L    +      A 
Sbjct: 1403 --------LQAAEEH-------VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIE-------KLQTKVLELQRKLDNTTAAVQELGRE 1333
            L+   +N         ++C +   E+E        L T++ +++   + +   ++ L RE
Sbjct: 1448 LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507

Query: 1334 NQSLQ 1338
            N++LQ
Sbjct: 1508 NKNLQ 1512



 Score =  113 bits (283), Expect = 1e-24
 Identities = 123/538 (22%), Positives = 239/538 (44%), Gaps = 59/538 (10%)

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH-QLQVQMENTLKEQKELKKSLEKE 922
            K+   LK++++E E    K +   +  E    E K  +L+ +M   LKE+ +L+  ++ E
Sbjct: 841  KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900

Query: 923  KEASHQLKLELNSMQEQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQK----KKQI 975
             E     +   + + +  IQ +  +K+     ++E+++   +   K+  E +    KK I
Sbjct: 901  AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960

Query: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
            + L+  L     +K   ENK++       +E+A   E I+ L    +  QE  +Q   D 
Sbjct: 961  DDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016

Query: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
               E ++      L   + KL    +DL  +  Q   + KL  +L+ AK  LE D    +
Sbjct: 1017 QAEEDKV----NTLTKAKIKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLEGDLKLAQ 1069

Query: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN-------EELK 1148
            + + +     Q + ++   KE E+ N +SK+ + + +  + +K+I +L        EE++
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129

Query: 1149 SHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
            + +    K      D  + L  I ++LE  G A S  A +E  K+ +   +   +  EE 
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATS--AQIEMNKKREAEFQKMRRDLEEA 1187

Query: 1207 ----------LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
                      L+K+  +  A+L  +I   +   +K E+ ++++ M+I  L  N+ TV K 
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247

Query: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
              + ++    LE Q  +L+           + ++E++ L+       G   +LQT+  E 
Sbjct: 1248 KGNLEKMCRTLEDQLSELK-----------SKEEEQQRLINDLTAQRG---RLQTESGEF 1293

Query: 1317 QRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHC 1374
             R+LD   A V +L R  Q+   +  + L R+  E+ + +N +A     ++   RH C
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAF-TQQIEELKRQLEEEIKAKNALA----HALQSSRHDC 1346



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 141/749 (18%), Positives = 299/749 (39%), Gaps = 133/749 (17%)

Query: 2    LRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYE 61
            L+R+ Q+          ++D  A+ + TV     S ++G +   C        EL    E
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNVETV-----SKAKGNLEKMCRTLEDQLSELKSKEE 1270

Query: 62   AVHDAGND--------SGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL 113
                  ND            GE +  L   +  L+ Q  +  QA  ++ +    +L++E+
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEA-LVSQLSRGKQAFTQQIEELKRQLEEEI 1329

Query: 114  EKYQGLQQ--QEAKPD-GLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLA 169
            +    L    Q ++ D  L+ +   E Q  + +L+ A ++ N  + Q +  +E  A Q  
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 170  TEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKE 229
             E+ + K K  +     +AAE+ V    E +N +   ++  K  L     +ED+ +  + 
Sbjct: 1390 EELEEAKKKLAQRL---QAAEEHV----EAVNAKCASLEKTKQRLQNE--VEDLMLDVER 1440

Query: 230  LVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE 289
                   +D      ++   + K +C++  ++  +S+     L +EL K        + +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 290  LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
            L+ LK     L Q+   LTE + +  +   +LE+   +    K  +QA L + +   +  
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE 1560

Query: 350  QSRLSASETSLHRI---------------------HVELSEKGEAT-------------- 374
            + ++   +  L+++                     H+ + E  ++T              
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620

Query: 375  -QKLKEELSEVETKYQH---LKAEFKQ-------------------LQQQREEKEQHGLQ 411
             +K++ +L+E+E +  H   + AE  +                   L+ Q + KEQ  + 
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680

Query: 412  ------LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
                  LQ+EI +L + L +TER            R+++ ++L+D  ++V  L  + + L
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERS-----------RKIAEQELLDASERVQLLHTQNTSL 1729

Query: 466  EEQLKEKVTNSTELQHQLDKTKQQHQ-----------------EQQALQQSTTAKLREAQ 508
                K+  T+ +++Q +++   Q+ +                 E+   +Q T+A L   +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789

Query: 509  NDLEQVLRQI-------------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
             ++EQ ++ +             G K Q IQ LEA +++ +  +   +K   +    ++ 
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQ-IQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             E     L    E++     ++  L +KL+ + +S+K+  E   +Q     A  R  Q  
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908

Query: 616  VLSLETSVNELNSQLNESKEKVSQLDIQI 644
            +   E   +   SQ+N+ + K  ++  ++
Sbjct: 1909 LEEAEERADIAESQVNKLRVKSREVHTKV 1937


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  213 bits (541), Expect = 1e-54
 Identities = 224/1110 (20%), Positives = 481/1110 (43%), Gaps = 93/1110 (8%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E   IK +  +  + R+  E+K+  L +E N     +Q     L      E
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE--E 909

Query: 222  DVAVLKKELVQVQTLMDNMTLERERESE----------KLKDECKKLQSQYASSEATISQ 271
                L K  +Q++  +  +T   E E E          KL+DEC +L+      E T+++
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +  E      +V    +E+  L  ++ +LT++ + L E   +   D    E+K N  + +
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029

Query: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
            K  ++  +   +   +Q +      E +  ++  +L    E+   ++ E  +++ K +  
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL-GEAHGRLKEQRQLSSEKLMD 450
            + E   LQ + E+++  G+QLQ +I +L +++ E E ++  E   R K ++Q S     D
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS-----D 1144

Query: 451  KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
              +++ ++  +L         ++  + + + +  K ++  +E     ++T A LR+   D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 511  LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
                   + +  ++I NL+ + QK ++  S ++ E +DL + +   E  +     L++  
Sbjct: 1205 ------SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV---ETVSKAKGNLEKMC 1255

Query: 571  HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
             TL++Q+++L        +S ++ Q+ L + +  Q+  L+               L SQL
Sbjct: 1256 RTLEDQLSEL--------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL 1307

Query: 631  NESKEKVS--------QLDIQIKAKTELLLSAEAAKTAQRAD-LQNHLDTAQNALQDKQQ 681
            +  K+  +        QL+ +IKAK  L  + ++++     D L+   +  Q +  + Q+
Sbjct: 1308 SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR--HDCDLLREQYEEEQESKAELQR 1365

Query: 682  ELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
             L+K  T++ Q   K + D  +   +LE   K+  ++  + E+  E +  +   LE    
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ 1425

Query: 741  EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
             ++   E  + D+++       L+ +     K L   K+    T  +L+   +   S+  
Sbjct: 1426 RLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGT 1485

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ------TTVTELQKVKMEKEALMTE 854
            +L K +   +      ETL +E K   +E+++  +        + EL+K+K + E    E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 855  LSTV-----------KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
            L              + K+ ++   L   KSE +++  +    I  L++    +   +Q 
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605

Query: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
             ++  ++ + +  +  +K +   ++++++LN       +A    +  +   +  Q ++++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665

Query: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ---AAQELAAEKEKISVLQNN 1020
              +S E  K+Q+  ++    +   +  EL   L+Q       A QEL    E++ +L   
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
                  T K+L++D    + E+    Q+ ++ EEK   A  D      ++  +      L
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK--EKELVNEKSKLAEIEEIKCRQEK 1138
            +  K  +EQ    K+ QL+       D  ++ +LK  +K++   ++++ E+E     ++K
Sbjct: 1786 ERMKKNMEQ--TVKDLQLR------LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837

Query: 1139 EITKLNEELKSHKLESIKEIT--NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
               +  + L+ H+   +KE+T    +D K +     L LQ   D L+A V+  KR  +  
Sbjct: 1838 RNAEAVKGLRKHE-RRVKELTYQTEEDRKNI-----LRLQDLVDKLQAKVKSYKRQAE-- 1889

Query: 1197 KDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
                  E EE     + K  KL  E++E E
Sbjct: 1890 ------EAEEQSNTNLAKFRKLQHELEEAE 1913



 Score =  202 bits (514), Expect = 2e-51
 Identities = 235/1150 (20%), Positives = 496/1150 (43%), Gaps = 134/1150 (11%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E+E   +K+E +K++ + A SEA   +L  ++    +E      ++Q     + +  +
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            +   L +  ++ E    ++ E+  +E      + A   + + +C +L+  +   E +L +
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EE++ ++     L  E K LQ+  ++        + ++N L   
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029

Query: 423  LLETERQLGEAHGRLKEQRQLSSE----------KLMDKEQQVADLQLKLSRLEEQLKEK 472
             ++ E+Q+ +  G L+++++L  +           L   ++ + D++ +  +L+E+LK+K
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
                + LQ ++       +++QAL      K++E Q  +E++       +++I+   A  
Sbjct: 1090 EFEISNLQSKI-------EDEQALGIQLQKKIKELQARIEEL-------EEEIEAERASR 1135

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH-------------TLQEQVTQ 579
             K+++  S L +E E++  +++   G T+   ++ +K               TLQ + T 
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 580  LTEKLKNQSESHKQAQ-----ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
             T + K+     +  +     + +  +++++K+ ++   D + S   +V++    L +  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 635  EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ-------------- 680
              +     ++K+K E         TAQR  LQ         L +K+              
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT 1315

Query: 681  QELNKITTQL-DQVTAK------LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI- 732
            Q++ ++  QL +++ AK      LQ  +  C  L    +E +E    L++   +   ++ 
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375

Query: 733  ---KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
                K E D+++     E+A + L Q+ Q   +           LE  K+ + +   DL 
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 790  KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
               E   +    L K++     +  +++   +ET  + E      ++  TEL K+K   E
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495

Query: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQME 906
              + +L T+K    + + +L+   S+  ++  +G   I +LEK  K++   K +LQ  +E
Sbjct: 1496 ESLDQLETLK----RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALE 1551

Query: 907  NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
                   E + SLE E+    +++LELN ++ ++ +     K  EK+E        E+ Q
Sbjct: 1552 -------EAEASLEHEEGKILRIQLELNQVKSEVDR-----KIAEKDE--------EIDQ 1591

Query: 967  SSEQKKKQIEALQGELKIAVLQKTE---LENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
                  + +E++Q  L   +  + +   L+ K++  L +   +L       +    NY  
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651

Query: 1024 SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA 1083
            +Q   K  Q        + L +++DLK   E+L++ +             N L  E++  
Sbjct: 1652 TQGILKDTQIHL----DDALRSQEDLK---EQLAMVER----------RANLLQAEIEEL 1694

Query: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
            +ATLEQ    ++   QE   A + +Q   + +   L+N K KL   E    + + E+  +
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHT-QNTSLINTKKKL---ETDISQMQGEMEDI 1750

Query: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV- 1200
             +E ++ + ++ K IT   DA  +  + K E    A  + +K  +EQ  ++ Q+  D+  
Sbjct: 1751 LQEARNAEEKAKKAIT---DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE 1807

Query: 1201 -------KKEEEELKKEFIEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENL 1250
                   KK+ ++L+    E E ++ SE K   E   G++KHE    +LT Q     +N+
Sbjct: 1808 QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867

Query: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
              ++      Q +V   ++Q ++   +     A  +  Q E     ER    E ++ KL+
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927

Query: 1311 TKVLELQRKL 1320
             K  E+  K+
Sbjct: 1928 VKSREVHTKV 1937



 Score =  174 bits (442), Expect = 4e-43
 Identities = 225/1014 (22%), Positives = 444/1014 (43%), Gaps = 154/1014 (15%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKPDGLVTDSSAELQSLEQQL 144
            L Q+V DL+ SL++EK    +L++   K +G   L Q+       + D   E Q L+++L
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES------IMDIENEKQQLDEKL 1086

Query: 145  EEAQTENFNIKQMKD-------LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
            ++ + E  N++   +         ++K  +L   I +++ + + ER+ R  AE++ + L+
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 198  EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257
             EL                    E+++   +E     +    M  +RE E +K++ + ++
Sbjct: 1147 REL--------------------EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 258  LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
               Q+   EAT + LR + A    E+   +  LQ++K                 L+KE+ 
Sbjct: 1187 ATLQH---EATAATLRKKHADSVAELGEQIDNLQRVKQK---------------LEKEKS 1228

Query: 318  YTKLE---EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
              K+E      N E+VSK   +  L +    C+ L+ +LS           EL  K E  
Sbjct: 1229 EMKMEIDDLASNVETVSK--AKGNLEKM---CRTLEDQLS-----------ELKSKEEEQ 1272

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
            Q+L  +L+    + Q    EF    +Q +EKE    QL         ++ E +RQL E  
Sbjct: 1273 QRLINDLTAQRGRLQTESGEF---SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE-- 1327

Query: 435  GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ----- 489
              +K +  L+    +   +   DL      L EQ +E+  +  ELQ  L K   +     
Sbjct: 1328 -EIKAKNALA--HALQSSRHDCDL------LREQYEEEQESKAELQRALSKANTEVAQWR 1378

Query: 490  -HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
               E  A+Q+  T +L EA+  L Q L+   +  + +    A L+K+K+    L+ E ED
Sbjct: 1379 TKYETDAIQR--TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR---LQNEVED 1433

Query: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE-SHKQAQE------NLHDQ 601
            L   ++      A L++ Q     +  +  Q  E+   + E S K+A+        + + 
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
             +E    L   +    +L+  +++L  Q+ E  +++ +L+ +IK + E           +
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVE----------QE 1542

Query: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTA----KLQDKQEHCSQLE-SHLKEYKE 716
            + +LQ  L+ A+ +L+ ++ ++ +I  +L+QV +    K+ +K E   QL+ +H++    
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR---- 1598

Query: 717  KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
                +E     L+ +I+    D++ +K   E  L ++  + QLN      A E  +    
Sbjct: 1599 ---IVESMQSTLDAEIRS-RNDAIRLKKKMEGDLNEM--EIQLN-HANRMAAEALRNYRN 1651

Query: 777  EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL-------SQETKIQHEE 829
             + I+  T++ L     + E +K++L   E    +L+ + E L        +  KI  +E
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711

Query: 830  L---NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
            L   + R+Q   T+   +   K+ L T++S ++ ++  +    +N++       +K K A
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE-------EKAKKA 1764

Query: 887  ILDLEKTCKELKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
            I D     +ELK +      +E   K  ++  K L+   + + QL L+    Q Q ++A+
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEAR 1824

Query: 945  NTLKQNEKEEQQLQGNINELK--QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
                + E E +Q + N   +K  +  E++ K++     E +  +L+  +L +KLQ ++  
Sbjct: 1825 VRELEGEVESEQ-KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883

Query: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
              ++    +E+ +     + K Q   ++ +      ES++   R   + V  K+
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937



 Score =  156 bits (394), Expect = 2e-37
 Identities = 202/930 (21%), Positives = 397/930 (42%), Gaps = 104/930 (11%)

Query: 84   DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
            D+ L ++ + D++    E++   E+LKK+  +   LQ +      L      +++ L+ +
Sbjct: 1064 DLKLAQESIMDIE---NEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE----------RSLREAAEQKV 193
            +EE + E    +  +   E++ + L+ E+ +I  + +E              REA  QK+
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180

Query: 194  TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
             R  E    EAT+  +     L++   + VA L +++  +Q +        +++ EK K 
Sbjct: 1181 RRDLE----EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKS 1228

Query: 254  ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS----VNELT-QKNQTLT 308
            E K      AS+  T+S+ +  L K  + +   + EL+  +      +N+LT Q+ +  T
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288

Query: 309  ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-- 366
            E+     +   +L+EK    S   +  QA   Q +   +QL+  + A     H +     
Sbjct: 1289 ES----GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 367  ----LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
                L E+ E  Q+ K EL    +K         ++ Q R + E   +Q   E+ +   K
Sbjct: 1345 DCDLLREQYEEEQESKAELQRALSKAN------TEVAQWRTKYETDAIQRTEELEEAKKK 1398

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQH 481
            L +   Q  E H      +  S EK   + + +V DL L + R                 
Sbjct: 1399 LAQ-RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457

Query: 482  QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
             L + KQ+ +E       T A+L  +Q +     R +G +  KI+N     ++S + +  
Sbjct: 1458 ILAEWKQKCEE-------THAELEASQKE----ARSLGTELFKIKN---AYEESLDQLET 1503

Query: 542  LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
            L++E ++L  +I      + +  Q+ E    + E      EK+K Q E  K     L   
Sbjct: 1504 LKRENKNLQQEI------SDLTEQIAEGGKRIHE-----LEKIKKQVEQEKC---ELQAA 1549

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLN----ESKEKVSQL---DIQIKAKTELLLSA 654
            ++E +A L   + ++L ++  +N++ S+++    E  E++ QL    I+I    +  L A
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ----LDQVTAKLQDKQEHCSQLESH 710
            E         L+  ++   N ++ +    N++  +           L+D Q H       
Sbjct: 1610 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK---EQALQDLQQQRQLNTDLELRA 767
             ++ KE+   +E++   L+ +I++L A   + + S+   EQ L D  ++ QL        
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 768  TELSKQLEMEKEIVSSTRLD-LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
                K+LE +   +     D LQ+   A E  K+ +T      + LK++     Q+T   
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE-----QDTSAH 1784

Query: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
             E +   ++ TV +LQ    E E L   L   K ++ K+   ++  + E E E ++   A
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842

Query: 887  ILDL---EKTCKELKHQLQVQMENTLKEQ---KELKKSLEKEKEASHQLKLELNSMQEQL 940
            +  L   E+  KEL +Q +   +N L+ Q    +L+  ++  K  + + + + N+   + 
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF 1902

Query: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
             + Q+ L++ E+     +  +N+L+  S +
Sbjct: 1903 RKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score =  123 bits (308), Expect = 1e-27
 Identities = 149/725 (20%), Positives = 307/725 (42%), Gaps = 86/725 (11%)

Query: 630  LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
            + E  +K+     + +AK + L         ++ DLQ  +      L D ++  +++   
Sbjct: 858  MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917

Query: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
              Q+ AK+++  E     E    E   K   LE +  EL+  I  LE    +V+  K   
Sbjct: 918  KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977

Query: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
               ++   +    L+    +L+K+ +  +E    T  DLQ + + + ++ +   K E++ 
Sbjct: 978  ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1037

Query: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQ-KVKMEKEALM---TELSTVKDKLSKV 865
              L+   E        Q ++L   ++    +L+  +K+ +E++M    E   + +KL K 
Sbjct: 1038 DDLEGSLE--------QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089

Query: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
               + N +S+ E E   G    + L+K  KEL+ +++ ++E  ++ ++  +   EK++  
Sbjct: 1090 EFEISNLQSKIEDEQALG----IQLQKKIKELQARIE-ELEEEIEAERASRAKAEKQRS- 1143

Query: 926  SHQLKLELNSMQEQLIQAQNT----LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
               L  EL  + E+L +A       ++ N+K E + Q    +L++++ Q +     L+ +
Sbjct: 1144 --DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201

Query: 982  LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
               +V +  E  + LQ+   +  +E +  K +I  L +N E   +    L+      E +
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
            L     +LKS EE+                 Q +LI +L   +  L+ +S +  +QL E+
Sbjct: 1262 L----SELKSKEEE-----------------QQRLINDLTAQRGRLQTESGEFSRQLDEK 1300

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
               +  + + K          ++   +IEE+K + E+EI   N    +H L+S +   +L
Sbjct: 1301 EALVSQLSRGK----------QAFTQQIEELKRQLEEEIKAKNA--LAHALQSSRHDCDL 1348

Query: 1162 -KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
             ++  +   + K ELQ         V Q +   +    Q  +E EE KK+  ++      
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------ 1402

Query: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
                    ++  EE+       + A+N    +++K  Q  Q  V +L    +      A 
Sbjct: 1403 --------LQAAEEH-------VEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIE-------KLQTKVLELQRKLDNTTAAVQELGRE 1333
            L+   +N         ++C +   E+E        L T++ +++   + +   ++ L RE
Sbjct: 1448 LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507

Query: 1334 NQSLQ 1338
            N++LQ
Sbjct: 1508 NKNLQ 1512



 Score =  113 bits (283), Expect = 1e-24
 Identities = 123/538 (22%), Positives = 239/538 (44%), Gaps = 59/538 (10%)

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH-QLQVQMENTLKEQKELKKSLEKE 922
            K+   LK++++E E    K +   +  E    E K  +L+ +M   LKE+ +L+  ++ E
Sbjct: 841  KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900

Query: 923  KEASHQLKLELNSMQEQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQK----KKQI 975
             E     +   + + +  IQ +  +K+     ++E+++   +   K+  E +    KK I
Sbjct: 901  AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960

Query: 976  EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
            + L+  L     +K   ENK++       +E+A   E I+ L    +  QE  +Q   D 
Sbjct: 961  DDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016

Query: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
               E ++      L   + KL    +DL  +  Q   + KL  +L+ AK  LE D    +
Sbjct: 1017 QAEEDKV----NTLTKAKIKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLEGDLKLAQ 1069

Query: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN-------EELK 1148
            + + +     Q + ++   KE E+ N +SK+ + + +  + +K+I +L        EE++
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129

Query: 1149 SHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206
            + +    K      D  + L  I ++LE  G A S  A +E  K+ +   +   +  EE 
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATS--AQIEMNKKREAEFQKMRRDLEEA 1187

Query: 1207 ----------LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
                      L+K+  +  A+L  +I   +   +K E+ ++++ M+I  L  N+ TV K 
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247

Query: 1257 WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
              + ++    LE Q  +L+           + ++E++ L+       G   +LQT+  E 
Sbjct: 1248 KGNLEKMCRTLEDQLSELK-----------SKEEEQQRLINDLTAQRG---RLQTESGEF 1293

Query: 1317 QRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHC 1374
             R+LD   A V +L R  Q+   +  + L R+  E+ + +N +A     ++   RH C
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAF-TQQIEELKRQLEEEIKAKNALA----HALQSSRHDC 1346



 Score = 94.0 bits (232), Expect = 9e-19
 Identities = 141/749 (18%), Positives = 299/749 (39%), Gaps = 133/749 (17%)

Query: 2    LRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYE 61
            L+R+ Q+          ++D  A+ + TV     S ++G +   C        EL    E
Sbjct: 1216 LQRVKQKLEKEKSEMKMEIDDLASNVETV-----SKAKGNLEKMCRTLEDQLSELKSKEE 1270

Query: 62   AVHDAGND--------SGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL 113
                  ND            GE +  L   +  L+ Q  +  QA  ++ +    +L++E+
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEA-LVSQLSRGKQAFTQQIEELKRQLEEEI 1329

Query: 114  EKYQGLQQ--QEAKPD-GLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLA 169
            +    L    Q ++ D  L+ +   E Q  + +L+ A ++ N  + Q +  +E  A Q  
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 170  TEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKE 229
             E+ + K K  +     +AAE+ V    E +N +   ++  K  L     +ED+ +  + 
Sbjct: 1390 EELEEAKKKLAQRL---QAAEEHV----EAVNAKCASLEKTKQRLQNE--VEDLMLDVER 1440

Query: 230  LVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE 289
                   +D      ++   + K +C++  ++  +S+     L +EL K        + +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 290  LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
            L+ LK     L Q+   LTE + +  +   +LE+   +    K  +QA L + +   +  
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE 1560

Query: 350  QSRLSASETSLHRI---------------------HVELSEKGEAT-------------- 374
            + ++   +  L+++                     H+ + E  ++T              
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620

Query: 375  -QKLKEELSEVETKYQH---LKAEFKQ-------------------LQQQREEKEQHGLQ 411
             +K++ +L+E+E +  H   + AE  +                   L+ Q + KEQ  + 
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680

Query: 412  ------LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
                  LQ+EI +L + L +TER            R+++ ++L+D  ++V  L  + + L
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERS-----------RKIAEQELLDASERVQLLHTQNTSL 1729

Query: 466  EEQLKEKVTNSTELQHQLDKTKQQHQ-----------------EQQALQQSTTAKLREAQ 508
                K+  T+ +++Q +++   Q+ +                 E+   +Q T+A L   +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1789

Query: 509  NDLEQVLRQI-------------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
             ++EQ ++ +             G K Q IQ LEA +++ +  +   +K   +    ++ 
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQ-IQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             E     L    E++     ++  L +KL+ + +S+K+  E   +Q     A  R  Q  
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908

Query: 616  VLSLETSVNELNSQLNESKEKVSQLDIQI 644
            +   E   +   SQ+N+ + K  ++  ++
Sbjct: 1909 LEEAEERADIAESQVNKLRVKSREVHTKV 1937


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  211 bits (538), Expect = 3e-54
 Identities = 243/1147 (21%), Positives = 509/1147 (44%), Gaps = 123/1147 (10%)

Query: 123  EAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE 182
            + KP   VT    ELQ+ +++L + + +   ++   +  E+K  QL  E   +  +   E
Sbjct: 840  KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899

Query: 183  RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ--VQTLMDNM 240
              L   AE+   RL  +  +   ++ DL++ + +      +   +K+ +Q  +Q L + +
Sbjct: 900  TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959

Query: 241  TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
              E E   +KL+ E    +++    E  I  L  + +K  +E  +    + +  S + E 
Sbjct: 960  D-EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 301  TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
             +K + L +   K+E   + LEE+  +E  +++ ++    + D +   LQ +++  +  +
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078

Query: 361  HRIHVELSEKGEATQ--------------KLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
              + ++L++K E  Q                 + + E++ +   L+ +F+  +  R + E
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138

Query: 407  QHGLQLQSEINQLHSKLLET-ERQLGEAHGRLKEQRQLS------SEKLMDKEQQVADLQ 459
            +    L  E+  L ++L +T +    +   R K +++++       E+  + E Q+ D++
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198

Query: 460  LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ--------EQQALQQ---STTAKLREAQ 508
             + +   E+L E++  +   +  L+K KQ  +        E + LQQ    +  K ++  
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 509  NDLEQVLRQIGDKDQ---KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
              ++++  ++ + D+   ++    + LQ   +N+S L +E E     I+  +   ++ +Q
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLESQ 1316

Query: 566  LQEKNHTLQEQVTQ---LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
            LQ+    LQE+  Q   L+ +++   E     QE   ++ + +K           +LE  
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK-----------NLEKQ 1365

Query: 623  VNELNSQLNESKEKVSQ----LDIQIKAKTELLLSAEA--AKTAQRADLQNHLDTAQNAL 676
            V  L SQL ++K+KV      ++   +AK +LL  AEA   +  ++A   + L+  +N L
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425

Query: 677  QDKQQELNKITTQLD---QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
               QQEL+ +T  LD   QV + L+ KQ+   QL +  K    +Y    ++ +  E + +
Sbjct: 1426 ---QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY---AEERDRAEAEAR 1479

Query: 734  KLEADSLEVKASKEQALQDLQ----QQRQLNTDLE----------LRATELSKQLEMEKE 779
            + E  +L +  + E+AL+  +    Q +QL  D+E              EL K     ++
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539

Query: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
             V   R  L++  + L++ +    + E   Q +K  FE   Q    Q+EE    +   V 
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
            EL+  ++E E     L+    K  K+   LK+ +++ E  N+     I  L K       
Sbjct: 1600 ELE-AELEDERKQRALAVASKK--KMEIDLKDLEAQIEAANKARDEVIKQLRK------- 1649

Query: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959
             LQ QM++  +E +E + S ++    S + + +L S++ +++Q Q  L  +E+  +  + 
Sbjct: 1650 -LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 960  NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
              +EL            AL  E           + +L+ ++ Q  +EL  E+  + +L +
Sbjct: 1709 ERDELADEITNSASGKSALLDE-----------KRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 1020 NYEKSQETFKQLQSDFYGRESELLAT---RQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
             + K+      L ++     S    +   RQ L+   ++L    ++L     +   ++K 
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL-----EGAVKSKF 1812

Query: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQK-EKSLKEKELVNEKSKLAEIEEIKCR 1135
               +   +A + Q   + EQ+ +ER  A + +++ EK LKE  +  E  +    ++ K +
Sbjct: 1813 KATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER-RHADQYKEQ 1871

Query: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
             EK   ++ ++LK    E+ +E T    +++       +LQ + D    A E   R    
Sbjct: 1872 MEKANARM-KQLKRQLEEAEEEATRANASRR-------KLQRELDDATEANEGLSREVST 1923

Query: 1196 LKDQVKK 1202
            LK+++++
Sbjct: 1924 LKNRLRR 1930



 Score =  206 bits (525), Expect = 1e-52
 Identities = 238/1031 (23%), Positives = 445/1031 (43%), Gaps = 163/1031 (15%)

Query: 397  QLQQQREE---KEQHGLQLQSEINQLHSKLLETER---QLGEAHGRLKEQRQLSSEKLMD 450
            Q+ +Q EE   K++  L+++ +  ++  +L E ER   QL E    L EQ Q  +E   +
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 451  KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
             E+  A L  K   LEE L           H L+   ++ +E+  + Q+   K++    D
Sbjct: 906  AEEMRARLAAKKQELEEIL-----------HDLESRVEEEEERNQILQNEKKKMQAHIQD 954

Query: 511  LEQVLRQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566
            LE+ L +     QK+Q      EA ++K +E I LLE +                    +
Sbjct: 955  LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF----------------I 998

Query: 567  QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
            +EK   +++++ + + +L  + E  K    NL     +Q+  +   ++R+   E +  EL
Sbjct: 999  KEKK-LMEDRIAECSSQLAEEEEKAK----NLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053

Query: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
                 +   + + L  QI                  A+LQ  +D  +  L  K++EL   
Sbjct: 1054 EKAKRKLDGETTDLQDQI------------------AELQAQIDELKLQLAKKEEELQGA 1095

Query: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746
              + D  T    +  +   +L++ + E +E + S +    + E Q + L  +   +K   
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155

Query: 747  EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK--------SEALESI 798
            E  L     Q++L T  E    EL K LE E +   +   D++++        SE LE  
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215

Query: 799  KQKLTKQEEEKQILKQDFETLS------QETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
            K+     E+ KQ L+ D + L+      Q+ K + E    ++   V EL     E + L 
Sbjct: 1216 KRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275

Query: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ------VQME 906
             EL+    KL    D++     E EK+  K       LE   ++ +  LQ      + + 
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335

Query: 907  NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
            + +++ +E K SL++++E   + +    ++++Q++  Q+ L   +K+     G I  L++
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEAR---KNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 967  SSEQKKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
            + ++  K  EAL   L+   L   +LE   N+LQQ+L     +L  +++  S    N EK
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS----NLEK 1448

Query: 1024 SQETFKQLQSDF------YGRE----------------------SELLATRQDLKSVEEK 1055
             Q+ F QL ++       Y  E                       E L  +++ +   ++
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQ 1508

Query: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
            L    EDL+S+++ +G   K + EL+ +K  LEQ   +   QL+E    LQ  +  K   
Sbjct: 1509 LRADMEDLMSSKDDVG---KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565

Query: 1116 EKELVNEKSKLAEIE-EIKCRQEKEITKLNEELKSHKLESIKEI-TNLKDAKQ---LLIQ 1170
            E   VN ++  A+ E +++ R E+     NEE K   ++ ++E+   L+D ++   L + 
Sbjct: 1566 E---VNMQAMKAQFERDLQTRDEQ-----NEEKKRLLIKQVRELEAELEDERKQRALAVA 1617

Query: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK 1230
             K +++     L+A +E   +     +D+V K+  +L+ +  + + +L      ++    
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANK----ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
            + +E+E KL     +L   +  +++E  SS+R     E++ D+L  EI    +      D
Sbjct: 1674 QSKESEKKLK----SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 1291 ERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV---------------------QE 1329
            E+R L  R  + E E+E+ Q+ +  L  +   TT  V                     Q+
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789

Query: 1330 LGRENQSLQIK 1340
            L R+N+ L+ K
Sbjct: 1790 LERQNKELKAK 1800



 Score =  194 bits (493), Expect = 5e-49
 Identities = 246/1108 (22%), Positives = 486/1108 (43%), Gaps = 149/1108 (13%)

Query: 352  RLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
            +++  E  L     EL +  E   K++ EL E+E K+Q L  E   L +Q + + +   +
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 412  LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE 471
             +    +L +K  E E  L +   R++E+ + +     +K++  A +Q     LEEQL E
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ----DLEEQLDE 961

Query: 472  KVTNSTELQHQL----DKTKQQHQEQQALQQSTTAKLRE---AQNDLEQVLRQIGDKDQK 524
            +     +LQ +      K K+  +E   L+   +  ++E    ++ + +   Q+ ++++K
Sbjct: 962  EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 525  IQNL-------EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
             +NL       E ++   +E +   EK R++L    +  +GET     LQ++   LQ Q+
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET---TDLQDQIAELQAQI 1078

Query: 578  TQLTEKLKNQSESHKQA-----QENLHDQ-----VQEQKAHLRAAQDRVLSLETSVNELN 627
             +L  +L  + E  + A      E LH       V+E +A +   Q+   S + S N+  
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138

Query: 628  SQLNESKEKVSQLDIQIK-------AKTELLLSAE----AAKTAQRADLQNHLDTAQNAL 676
             Q  +  E++  L  +++       A+ EL    E      K A   + +NH    Q+  
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198

Query: 677  QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
            Q     L +++ QL+Q      + +++   LE+  KE   +   L+Q   E E + KKL+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 737  ADSLEV----------------KASKEQALQD-----LQQQRQLNTDLELRATELSKQLE 775
            A   E+                KASK Q   D     L++  +        A  L  QL+
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318

Query: 776  MEKEIV---SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
              +E++   +  +L+L  +   LE  K  L +Q+EE++  +++ E      + Q  +   
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---DSLKNSKSEFEKENQKGKAAILD 889
            ++   +  ++ ++  K+ L+ +   +  +L + +   D L+ +K+  ++E          
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE---------- 1428

Query: 890  LEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN--------------S 935
            L+    +L HQ QV   N  K+QK+  + L +EK  S +   E +              S
Sbjct: 1429 LDDLTVDLDHQRQV-ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487

Query: 936  MQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
            +   L +A    ++ E++ +QL+ ++ +L  S +   K +  L+ + K A+ Q+ E   +
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE-KSKRALEQQVE---E 1543

Query: 996  LQQQLTQAAQELAAEKEKISVLQNNYEKSQETF-KQLQS-DFYGRESELLATRQDLKSVE 1053
            ++ QL +   EL A ++    L+ N +  +  F + LQ+ D    E + L     +K V 
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL----IKQVR 1599

Query: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ---QLQERCKALQDIQK 1110
            E  +  +++       + ++ K+  +LK  +A +E  +  +++   QL++    ++D Q+
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659

Query: 1111 --EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS----------HKLESIKEI 1158
              E++   ++ +  +SK  E E+     E EI +L EEL S           + E   EI
Sbjct: 1660 ELEEARASRDEIFAQSK--ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717

Query: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK---------------- 1202
            TN    K  L+ +K  L+ +   L+  +E+E+ N ++L D+ +K                
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 1203 ----EEEELKKEFIEKEAKLHSEIKEKEVGMK-KHEENEAKLTMQITALNENLGTVKKEW 1257
                + +  +++   +  +L ++++E E  +K K +   + L  +I  L E L    KE 
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837

Query: 1258 QSSQRRVSELEK-------QTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
             ++ + V   EK       Q +D R      +  ++      + L  +  + E E  +  
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897

Query: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQ 1338
                +LQR+LD+ T A + L RE  +L+
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLK 1925



 Score =  191 bits (484), Expect = 6e-48
 Identities = 205/975 (21%), Positives = 442/975 (45%), Gaps = 123/975 (12%)

Query: 92   VQDLQASLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
            + DL+  LK+E+   +EL+K   K  G    LQ Q A+    + +   +L   E++L+ A
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095

Query: 148  QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207
                 +    K+   +   +L  +IA+++  ++ E++ R  AE++   L+EEL       
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL------- 1148

Query: 208  QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267
            + LKTEL             ++ +        +  +RE+E  +LK   K L+ +  + EA
Sbjct: 1149 EALKTEL-------------EDTLDTTAAQQELRTKREQEVAELK---KALEEETKNHEA 1192

Query: 268  TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL--KKEQDYTKLEEKH 325
             I  +R   A   +E++  +++ ++ K+++ +  Q  +T  + L    K     K E +H
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252

Query: 326  NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
              + +            D   Q+L +++S  +    R+ VEL+EK     KL+ EL  V 
Sbjct: 1253 KRKKL------------DAQVQELHAKVSEGD----RLRVELAEKAS---KLQNELDNVS 1293

Query: 386  TKYQH--------------LKAEFKQLQQQREEKEQHGLQLQSEINQLHSK---LLETER 428
            T  +               L+++ +  Q+  +E+ +  L L S I QL  +   L E + 
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353

Query: 429  QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
            +  EA   L++Q      +L D +++V D    +  LEE  K+ + ++  L  +L++   
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413

Query: 489  QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
             + + +  +     +L +   DL+   +   + ++K +  + LL + K   +   +ER+ 
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473

Query: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
              A+ +  E +   L +  E+    +E+  +  ++L+   E    +++++   V E +  
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533

Query: 609  LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668
             RA + +V  + T + EL  +L  +++   +L++ ++              A +A  +  
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ--------------AMKAQFERD 1579

Query: 669  LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
            L T     ++K++ L K   Q+ ++ A+L+D             E K++ L++  K +++
Sbjct: 1580 LQTRDEQNEEKKRLLIK---QVRELEAELED-------------ERKQRALAVASK-KKM 1622

Query: 729  EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDL 788
            E  +K LEA   +++A+ +   + ++Q R+L   ++    EL +      EI + ++ + 
Sbjct: 1623 EIDLKDLEA---QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK-ES 1678

Query: 789  QKKSEALES----IKQKLTKQEEEKQILKQDFETLSQET------KIQHEELNNRIQTTV 838
            +KK ++LE+    ++++L   E  ++  +Q+ + L+ E       K    +   R++  +
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738

Query: 839  TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
             +L++   E+++ M  L+    K +   D+L    +      QK   A   LE+  KELK
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798

Query: 899  HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
             +LQ ++E  +K   + K ++   +    QL+ +L    ++   A   +++ EK+ +++ 
Sbjct: 1799 AKLQ-ELEGAVK--SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855

Query: 959  GNINELKQSSEQKKKQIEALQGELKIAVLQKTELE----------NKLQQQLTQAAQELA 1008
              + + ++ ++Q K+Q+E     +K    Q  E E           KLQ++L  A +   
Sbjct: 1856 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE 1915

Query: 1009 AEKEKISVLQNNYEK 1023
                ++S L+N   +
Sbjct: 1916 GLSREVSTLKNRLRR 1930



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 129/584 (22%), Positives = 255/584 (43%), Gaps = 77/584 (13%)

Query: 841  LQKVKMEKEALMTEL-----STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE---- 891
            L  ++ E++  +T++     +  +  L++ + + K  +    K  Q+  AA L L     
Sbjct: 775  LAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQW 834

Query: 892  -KTCKELKHQLQV--QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948
             +   ++K  LQV  Q E    + +EL K  EK+ +   +L+ E+    +QL++ +N L 
Sbjct: 835  WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELE-EMERKHQQLLEEKNILA 893

Query: 949  QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE----LENK--------- 995
            +  + E +L     E++     KK+++E +  +L+  V ++ E    L+N+         
Sbjct: 894  EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 996  -LQQQLTQ---AAQELAAEK-----------EKISVLQNNYEKSQETFKQLQSDFYGRES 1040
             L++QL +   A Q+L  EK           E+I +L++   K  +  K+L  D     S
Sbjct: 954  DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE-KKLMEDRIAECS 1012

Query: 1041 ELLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
              LA  ++      K+   QE +IS+   ++  + K  QEL+ AK  L+ ++   + Q+ 
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072

Query: 1100 ERCKALQDIQKEKSLKEKEL-----------VNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
            E    + +++ + + KE+EL           +++ + L  + E+    + +I +L E+ +
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL----QAQIAELQEDFE 1128

Query: 1149 SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK 1208
            S K    K     +D  + L   K EL+   D+  A  E   + +Q + +  K  EEE K
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188

Query: 1209 ------KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
                  ++  ++ A    E+ E+    K+ + N  K    +   N+ L    K  Q  + 
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK- 1247

Query: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK--- 1319
              +E E +   L  ++  L A V      R  L E+  K + E++ + T + E ++K   
Sbjct: 1248 --AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305

Query: 1320 -------LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
                   L++     QEL +E    ++  +  + +   E N +Q
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  211 bits (538), Expect = 3e-54
 Identities = 262/1192 (21%), Positives = 526/1192 (44%), Gaps = 139/1192 (11%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E    K +  +  + R+  E+K+  L +E N     +Q     L      E
Sbjct: 849  EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE--E 906

Query: 222  DVAVLKKELVQVQTLMDNMTLERERESE----------KLKDECKKLQSQYASSEATISQ 271
                L K  +Q++  +  +T   E E E          KL+DEC +L+      E T+++
Sbjct: 907  RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 966

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +  E      +V    +E+  L  ++ +L+++ + L E   +   D    E+K N  + +
Sbjct: 967  VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKA 1026

Query: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
            K  ++  +   +   +Q +      E +  ++  +L    E+T  ++ +  +++ K +  
Sbjct: 1027 KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKK 1086

Query: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
            + E   L  + E+++   +QLQ +I +L +++ E           L E+ +         
Sbjct: 1087 EFEISNLISKIEDEQAVEIQLQKKIKELQARIEE-----------LGEEIEAERASRAKA 1135

Query: 452  EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ-------QHQEQQALQ-QSTTAK 503
            E+Q +DL  +L  + E+L E+   +T  Q +L+K ++       +  E+  LQ ++  A 
Sbjct: 1136 EKQRSDLSRELEEISERL-EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194

Query: 504  LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
            LR+   D       + +  ++I NL+ + QK ++  S L+ E +DL +     E  +   
Sbjct: 1195 LRKKHAD------SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSN---AEAISKAK 1245

Query: 564  NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
              L++   +L++QV++L  K        ++ Q+ L + +  Q+A           L+T  
Sbjct: 1246 GNLEKMCRSLEDQVSELKTK--------EEEQQRLINDLTAQRAR----------LQTEA 1287

Query: 624  NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
             E + QL+E    VSQL    +A T+ +   +  +  +    +N L    +ALQ  + + 
Sbjct: 1288 GEYSRQLDEKDALVSQLSRSKQASTQQIEELK-HQLEEETKAKNAL---AHALQSSRHDC 1343

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLEV 742
            + +  Q ++      + Q   S+  S + +++ KY     Q+TEELE   KKL       
Sbjct: 1344 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL------- 1396

Query: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
                    Q LQ+  +    +  +   L K  +  +  V    LD+++ + A  ++ +K 
Sbjct: 1397 -------AQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449

Query: 803  TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
               ++     KQ +E    ET+ + E      ++  TEL KVK   E  + +L T    L
Sbjct: 1450 RNFDKVLSEWKQKYE----ETQAELEASQKESRSLSTELFKVKNVYEESLDQLET----L 1501

Query: 863  SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
             + + +L+   S+  ++  +G   I +LEK  K+++ Q + +++  L   +E + SLE E
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVE-QEKCEIQAAL---EEAEASLEHE 1557

Query: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK-KKQIEALQGE 981
            +    +++LELN ++ ++      + + ++E  QL+ N   + ++ +     +I +    
Sbjct: 1558 EGKILRIQLELNQVKSEV---DRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDA 1614

Query: 982  LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
            L++    + +L N+++ QL   A  LAAE  +      NY  +Q   K+ Q        +
Sbjct: 1615 LRVKKKMEGDL-NEMEIQLNH-ANRLAAESLR------NYRNTQGILKETQLHL----DD 1662

Query: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
             L  ++DLK   E+L++ +             N L  E++   ATLEQ    ++   QE 
Sbjct: 1663 ALRGQEDLK---EQLAIVER----------RANLLQAEIEELWATLEQTERSRKIAEQEL 1709

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL 1161
              A + +Q   + +   L+N K KL   E    + + E+ ++ +E ++ + ++ K IT  
Sbjct: 1710 LDASERVQLLHT-QNTSLINTKKKL---ENDVSQLQSEVEEVIQESRNAEEKAKKAIT-- 1763

Query: 1162 KDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQV--------KKEEEELKKEF 1211
             DA  +  + K E    A  + +K  +EQ  ++ Q   D+         KK+ ++L+   
Sbjct: 1764 -DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822

Query: 1212 IEKEAKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
             E E ++ +E K   E   G++KHE    +LT Q     +N+  ++      Q +V   +
Sbjct: 1823 RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882

Query: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
            +Q ++   +     +  +  Q E     ER    E ++ KL+ K  E+  K+
Sbjct: 1883 RQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934



 Score =  199 bits (507), Expect = 1e-50
 Identities = 254/1170 (21%), Positives = 489/1170 (41%), Gaps = 140/1170 (11%)

Query: 91   EVQDLQASLKEE-KWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
            E +   A++KEE +   +EL K   K + L+++         D   ++QS    L +A+ 
Sbjct: 847  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE- 905

Query: 150  ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
                 ++ + L + K  QL  +I ++  + +EE  +      K  +L +E ++    I D
Sbjct: 906  -----ERCEQLIKNKI-QLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD 959

Query: 210  LKTELL------------------QRPGI-EDVAVLKKELVQVQTLMDNMTLERERESEK 250
            L+  L                   +  G+ E +A L KE   +Q        + + E +K
Sbjct: 960  LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019

Query: 251  LKDECK---KLQSQYASSEATISQ---LRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
            +    K   KL+ Q    E ++ Q   LR +L +  +++     +L+  + S  ++    
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE---GDLKLAQESTMDMENDK 1076

Query: 305  QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
            Q L E L KKE + + L  K  +E   +  +Q  + +     ++L   + A   S  +  
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136

Query: 365  VELSEKGEATQKLKEELSE----VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
             + S+     +++ E L E       + +  K    + Q+ R + E+  LQ ++ +  L 
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196

Query: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
             K  ++  +LGE    L+  +Q   ++  + + +  DL      + +           L+
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256

Query: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
             Q+ + K + +EQQ L    TA+    Q +  +  RQ+ +KD  +  L    Q S + I 
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE 1316

Query: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
             L+ + E+          ET   N L     + +     L E+ + + E   + Q  L  
Sbjct: 1317 ELKHQLEE----------ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL-- 1364

Query: 601  QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
                 KA+   AQ R    ET   +   +L E+K+K++Q   + +   E       A  A
Sbjct: 1365 ----SKANSEVAQWRT-KYETDAIQRTEELEEAKKKLAQRLQEAEEHVE-------AVNA 1412

Query: 661  QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720
            + A L+      QN ++D   ++ +     +   A L  KQ +  ++   L E+K+KY  
Sbjct: 1413 KCASLEKTKQRLQNEVEDLMLDVER----SNAACAALDKKQRNFDKV---LSEWKQKYEE 1465

Query: 721  LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
             + + E  + + + L  +  +VK   E++L  L+  R+ N +L+   ++L++Q+      
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQI------ 1519

Query: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
                  +  K+   LE IK+++ +++ E Q   ++      E  ++HEE   +I     E
Sbjct: 1520 -----AEGGKQIHELEKIKKQVEQEKCEIQAALEE-----AEASLEHEE--GKILRIQLE 1567

Query: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
            L +VK E +  + E    KD   +  D LK + +   +  Q    + LD E   +    +
Sbjct: 1568 LNQVKSEVDRKIAE----KD---EEIDQLKRNHTRVVETMQ----STLDAEIRSRNDALR 1616

Query: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
            ++ +ME  L E          E + +H  +L   S++      Q  LK+ +         
Sbjct: 1617 VKKKMEGDLNEM---------EIQLNHANRLAAESLRNYR-NTQGILKETQLHLDDALRG 1666

Query: 961  INELKQSSEQKKKQIEALQGELK--IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
              +LK+     +++   LQ E++   A L++TE   K+      A QEL    E++ +L 
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKI------AEQELLDASERVQLLH 1720

Query: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
                    T K+L++D    +SE+    Q+ ++ EEK   A  D      ++  +     
Sbjct: 1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780

Query: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK--EKELVNEKSKLAEIEEIKCRQ 1136
             L+  K  LEQ     + +L E         ++ +LK  +K++   ++++ E+E     +
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDE--------AEQLALKGGKKQIQKLEARVRELEGEVENE 1832

Query: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
            +K   +  + L+ H+   +KE+T   +  +   +  L LQ   D L+A V+  KR  +  
Sbjct: 1833 QKRNAEAVKGLRKHE-RRVKELTYQTEEDR---KNVLRLQDLVDKLQAKVKSYKRQAE-- 1886

Query: 1197 KDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
                  E EE     + K  KL  E++E E
Sbjct: 1887 ------EAEEQSNANLSKFRKLQHELEEAE 1910



 Score =  188 bits (477), Expect = 4e-47
 Identities = 248/1165 (21%), Positives = 521/1165 (44%), Gaps = 160/1165 (13%)

Query: 317  DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL----QSRLSASETSLHRIHVELSEKGE 372
            +Y K+ ++       + N++A ++ K     +L    +  L ++ET       E++   E
Sbjct: 803  EYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEK-----EMATMKE 857

Query: 373  ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN----------QLHSK 422
              QK K+EL++ E K + L+ +   L +++ + +   LQ+QSE +          QL   
Sbjct: 858  EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQSEADSLADAEERCEQLIKN 914

Query: 423  LLETERQLGEAHGRLKEQRQLSSE------KLMDK----EQQVADLQLKLSRLEEQ---L 469
             ++ E ++ E   R +E+ ++++E      KL D+    ++ + DL+L L+++E++    
Sbjct: 915  KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974

Query: 470  KEKVTNSTELQHQLDKT-KQQHQEQQALQQSTTAKLRE--AQNDLEQVLRQIGDK-DQKI 525
            + KV N TE    LD+T  +  +E++ALQ++    L +  A+ D   +L +   K +Q++
Sbjct: 975  ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV 1034

Query: 526  QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN----QLQEKNHTLQEQVTQLT 581
             +LE  L++ K+    LE+ +  L   ++  +  T  +     QL EK    + +++ L 
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094

Query: 582  EKLKNQSESHKQAQENLHD---QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
             K++++     Q Q+ + +   +++E    + A +      E   ++L+ +L E  E++ 
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLE 1154

Query: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNHL---DTAQNALQDKQQE-LNKITTQLDQVT 694
            +      A+ EL    EA     R DL+      +    AL+ K  + + ++  Q+D + 
Sbjct: 1155 EAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQ 1214

Query: 695  AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQ 751
               Q  ++  S+L+    +      ++ +    LE   + LE    E+K  +E+    + 
Sbjct: 1215 RVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN 1274

Query: 752  DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI 811
            DL  QR     L+  A E S+QL+ +  +VS      Q  ++ +E +K +L ++ + K  
Sbjct: 1275 DLTAQR---ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNA 1331

Query: 812  L-------KQDFETLSQETKIQHE---ELNNRIQTTVTELQ--KVKMEKEALMT--ELST 857
            L       + D + L ++ + + E   EL   +    +E+   + K E +A+    EL  
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1391

Query: 858  VKDKLS---------------------KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
             K KL+                     K    L+N   +   + ++  AA   L+K  + 
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451

Query: 897  LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
                L    +   + Q EL+ S ++ +  S +L    N  +E L Q +   ++N+  +Q+
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQE 1511

Query: 957  LQG-------------NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
            +                + ++K+  EQ+K +I+A   E + ++  +     ++Q +L Q 
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571

Query: 1004 AQE----LAAEKEKISVLQNNYEKSQETFKQ-LQSDFYGRESELLATRQ---DLKSVEEK 1055
              E    +A + E+I  L+ N+ +  ET +  L ++   R   L   ++   DL  +E +
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQ 1631

Query: 1056 LS----LAQEDLISNRNQIG--NQNKLI--------QELKTAKATLEQDSAKKEQQLQER 1101
            L+    LA E L + RN  G   + +L         ++LK   A +E+ +   + +++E 
Sbjct: 1632 LNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691

Query: 1102 CKALQDIQKEKSLKEKELVNEKSKL-------AEIEEIKCRQEKEITKLNEELKSHKLES 1154
               L+  ++ + + E+EL++   ++         +   K + E ++++L  E++    E 
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE----EV 1747

Query: 1155 IKEITNLKD-AKQLLIQQKL---ELQGKADSLKAAVEQEKRN-QQILKDQVKK--EEEEL 1207
            I+E  N ++ AK+ +    +   EL+ + D+  A +E+ K+N +Q +KD   +  E E+L
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNLEQTVKDLQHRLDEAEQL 1806

Query: 1208 KKEFIEKEA-KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
              +  +K+  KL + ++E E  ++  ++  A+                K  +  +RRV E
Sbjct: 1807 ALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV--------------KGLRKHERRVKE 1852

Query: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
            L  QT++ R  +  L+  V   Q + ++   +  + E +     +K  +LQ +L+     
Sbjct: 1853 LTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEER 1912

Query: 1327 VQELGRENQSLQIKHTQALNRKWAE 1351
                  +   L++K  +   +  AE
Sbjct: 1913 ADIAESQVNKLRVKSREVHTKISAE 1937



 Score =  180 bits (456), Expect = 1e-44
 Identities = 223/1031 (21%), Positives = 461/1031 (44%), Gaps = 126/1031 (12%)

Query: 58   KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
            K  +  H    D     E  + +     T L Q+V DL+ SL++EK    +L+ +LE+ +
Sbjct: 1000 KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEK----KLRMDLERAK 1055

Query: 118  GLQQQEAKPDGLVTDSSAELQSLEQQLEE-AQTENFNIKQMKDLFEQKAA---QLATEIA 173
               + + K   L  +S+ ++++ +QQL+E  + + F I  +    E + A   QL  +I 
Sbjct: 1056 RKLEGDLK---LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIK 1112

Query: 174  DIKSKYDE-------ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
            +++++ +E       ER+ R  AE++ + L+ EL                    E+++  
Sbjct: 1113 ELQARIEELGEEIEAERASRAKAEKQRSDLSREL--------------------EEISER 1152

Query: 227  KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
             +E     +    +  +RE E +KL+ + ++   Q+   EA ++ LR + A    E+   
Sbjct: 1153 LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH---EAMVAALRKKHADSMAELGEQ 1209

Query: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
            +  LQ++K  + +  +K++      LK E D    +   N E++SK   +  L +    C
Sbjct: 1210 IDNLQRVKQKLEK--EKSE------LKMETD----DLSSNAEAISK--AKGNLEKM---C 1252

Query: 347  QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
            + L+ ++S           EL  K E  Q+L   ++++  +   L+ E  +  +Q +EK+
Sbjct: 1253 RSLEDQVS-----------ELKTKEEEQQRL---INDLTAQRARLQTEAGEYSRQLDEKD 1298

Query: 407  QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
                   + ++QL      + +Q+ E   +L+E+ +  +      +    D  L    L 
Sbjct: 1299 -------ALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL----LR 1347

Query: 467  EQLKEKVTNSTELQHQLDKTKQQ------HQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
            EQ +E+     ELQ  L K   +        E  A+Q+  T +L EA+  L Q L++  +
Sbjct: 1348 EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRLQEAEE 1405

Query: 521  KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 580
              + +    A L+K+K+    L+ E EDL   ++      A L++ Q     +  +  Q 
Sbjct: 1406 HVEAVNAKCASLEKTKQR---LQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK 1462

Query: 581  TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640
             E+ + + E+ ++   +L  ++ + K     + D++ +L      L  ++++  E++++ 
Sbjct: 1463 YEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEG 1522

Query: 641  DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
              QI    ++    E     ++ ++Q  L+ A+ +L+ ++ ++ +I  +L+QV +++  K
Sbjct: 1523 GKQIHELEKIKKQVE----QEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1578

Query: 701  QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
                 +    LK    + +   Q T  L+ +I+    D+L VK   E  L ++  + QLN
Sbjct: 1579 IAEKDEEIDQLKRNHTRVVETMQST--LDAEIRS-RNDALRVKKKMEGDLNEM--EIQLN 1633

Query: 761  TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL- 819
                L A  L +     + I+  T+L L       E +K++L   E    +L+ + E L 
Sbjct: 1634 HANRLAAESL-RNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELW 1692

Query: 820  ------SQETKIQHEEL---NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
                   +  KI  +EL   + R+Q   T+   +   K+ L  ++S ++ ++ +V    +
Sbjct: 1693 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESR 1752

Query: 871  NSKSEFEKENQKGKAAILDLEKTCKELKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQ 928
            N++       +K K AI D     +ELK +      +E   K  ++  K L+   + + Q
Sbjct: 1753 NAE-------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1805

Query: 929  LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK--QSSEQKKKQIEALQGELKIAV 986
            L L+    Q Q ++A+    + E E +Q + N   +K  +  E++ K++     E +  V
Sbjct: 1806 LALKGGKKQIQKLEARVRELEGEVENEQ-KRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864

Query: 987  LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
            L+  +L +KLQ ++    ++    +E+ +   + + K Q   ++ +      ES++   R
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLR 1924

Query: 1047 QDLKSVEEKLS 1057
               + V  K+S
Sbjct: 1925 VKSREVHTKIS 1935



 Score =  176 bits (445), Expect = 2e-43
 Identities = 212/963 (22%), Positives = 432/963 (44%), Gaps = 123/963 (12%)

Query: 447  KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
            K  + E+++A ++ +  + +++L +      EL+ ++    ++  + Q   QS    L +
Sbjct: 844  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903

Query: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKE-NISLLEKER--EDLYAKIQAGEGETAV- 562
            A+   EQ+++     + KI+ +    ++ +E N  L  K+R  ED  ++++    +  + 
Sbjct: 904  AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSES------HKQAQENLHDQVQEQKAHLRAAQDRV 616
            L +++++ H  + +V  LTE++    E+       K+A +  H Q  +    L+A +D+ 
Sbjct: 964  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD---LQAEEDK- 1019

Query: 617  LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
                  VN L     + +++V  L+  ++ + +L +  E AK     DL+   ++  +  
Sbjct: 1020 ------VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073

Query: 677  QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
             DKQ        QLD+   KL+ K+   S L S +++ +   + L++K +EL+ +I++L 
Sbjct: 1074 NDKQ--------QLDE---KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELG 1122

Query: 737  ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALE 796
             +    +AS+ +A    ++QR   +DL     E+S++LE E    +S +++L KK EA  
Sbjct: 1123 EEIEAERASRAKA----EKQR---SDLSRELEEISERLE-EAGGATSAQVELNKKREA-- 1172

Query: 797  SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
               QKL +  EE  +     E +    + +H +    +   +  LQ+VK + E   +EL 
Sbjct: 1173 -EFQKLRRDLEEATL---QHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELK 1228

Query: 857  TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
               D LS  ++++  +K               +LEK C+ L+ Q+  +++   +EQ+ L 
Sbjct: 1229 METDDLSSNAEAISKAKG--------------NLEKMCRSLEDQVS-ELKTKEEEQQRLI 1273

Query: 917  KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
              L  ++    +L+ E      QL +    + Q  + +Q     I ELK   E++ K   
Sbjct: 1274 NDLTAQRA---RLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKN 1330

Query: 977  ALQGELKIA----------VLQKTELENKLQQQLTQAAQELAAEKEKISV-LQNNYEKSQ 1025
            AL   L+ +            ++ E + +LQ+ L++A  E+A  + K         E+ +
Sbjct: 1331 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE 1390

Query: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
            E  K+L       E  + A      S+E+     Q ++      +   N     L   + 
Sbjct: 1391 EAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQR 1450

Query: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS----KLAEIEEIKCRQEKEIT 1141
              ++  ++ +Q+ +E    L+  QKE      EL   K+     L ++E ++ R+ K + 
Sbjct: 1451 NFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR-RENKNLQ 1509

Query: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
            +   +L     E  K+I  L+  K+ + Q+K E+Q   +  +A++E E+     ++ ++ 
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELN 1569

Query: 1202 KEEEELKKEFIEK------------------EAKLHSEIKEKEVGM---KKHEENEAKLT 1240
            + + E+ ++  EK                  ++ L +EI+ +   +   KK E +  ++ 
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629

Query: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDD-LRGEIAVLEATVQNNQDERRALLERC 1299
            +Q+   N       + ++++Q  + E +   DD LRG         Q +  E+ A++ER 
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG---------QEDLKEQLAIVER- 1679

Query: 1300 LKGEGEIEKLQTKVLELQRKLDNT----TAAVQELGRENQSLQIKHTQ---ALNRKWAED 1352
                     LQ ++ EL   L+ T      A QEL   ++ +Q+ HTQ    +N K   +
Sbjct: 1680 -----RANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1734

Query: 1353 NEV 1355
            N+V
Sbjct: 1735 NDV 1737



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 140/662 (21%), Positives = 275/662 (41%), Gaps = 108/662 (16%)

Query: 54   DELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL 113
            +EL    E    A N   H  +S+    R D  LLR++ +       EE+    EL++ L
Sbjct: 1316 EELKHQLEEETKAKNALAHALQSS----RHDCDLLREQYE-------EEQEGKAELQRAL 1364

Query: 114  EKYQG-LQQQEAKPDGLVTDSSAELQS----LEQQLEEAQTENFNIKQMKDLFEQKAAQL 168
             K    + Q   K +      + EL+     L Q+L+EA+     +       E+   +L
Sbjct: 1365 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424

Query: 169  ATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK 228
              E+ D+    +   +   A ++K     + L++     ++ + EL      ++   L  
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAEL--EASQKESRSLST 1482

Query: 229  ELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ 288
            EL +V+ + +    E   + E L+ E K LQ +       IS L  ++A+G +++     
Sbjct: 1483 ELFKVKNVYE----ESLDQLETLRRENKNLQQE-------ISDLTEQIAEGGKQI----H 1527

Query: 289  ELQKLKSSVN-ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
            EL+K+K  V  E  +    L E     E +  K+     E +  K  +   + +KD +  
Sbjct: 1528 ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1587

Query: 348  QLQ-SRLSASETSLHRIHVELSEKGEATQ---KLKEELSEVETKYQH---LKAEFKQ--- 397
            QL+ +     ET    +  E+  + +A +   K++ +L+E+E +  H   L AE  +   
Sbjct: 1588 QLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYR 1647

Query: 398  ----------------LQQQREEKEQHGLQ------LQSEINQLHSKLLETERQLGEAHG 435
                            L+ Q + KEQ  +       LQ+EI +L + L +TER       
Sbjct: 1648 NTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERS------ 1701

Query: 436  RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ---- 491
                 R+++ ++L+D  ++V  L  + + L    K+   + ++LQ ++++  Q+ +    
Sbjct: 1702 -----RKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEE 1756

Query: 492  -------------EQQALQQSTTAKLREAQNDLEQVLRQI-------------GDKDQKI 525
                         E+   +Q T+A L   + +LEQ ++ +             G K Q I
Sbjct: 1757 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ-I 1815

Query: 526  QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585
            Q LEA +++ +  +   +K   +    ++  E     L    E++     ++  L +KL+
Sbjct: 1816 QKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQ 1875

Query: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
             + +S+K+  E   +Q     +  R  Q  +   E   +   SQ+N+ + K  ++  +I 
Sbjct: 1876 AKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935

Query: 646  AK 647
            A+
Sbjct: 1936 AE 1937


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  211 bits (536), Expect = 5e-54
 Identities = 296/1320 (22%), Positives = 568/1320 (43%), Gaps = 175/1320 (13%)

Query: 94   DLQASLKEEKWYSEELKKELE----KYQGLQQQEAKPDGLVTDS-------SAELQSLEQ 142
            ++++ L  EK  +E+L  ELE    + QGL        G+ T+        S ++     
Sbjct: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHT 1678

Query: 143  QLEEAQTENFNIKQMKDLFEQKAAQL----ATEIADIK------SKYDEERSLREAAEQK 192
                 +T   ++ Q+ D   Q+   L     TE   +K       +   + +     E K
Sbjct: 1679 SETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDK 1738

Query: 193  VTRLTEELNK------EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
                +E +++       A V  D    L  +  I ++ +  KE       + ++  +R+R
Sbjct: 1739 TQGSSECISELSFSGPNALVPMDF---LGNQEDIHNLQLRVKETSNENLRLLHVIEDRDR 1795

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ---- 302
            + E L +E K+L S+    E    QL +++ +   E+   V EL+K  S ++E  +    
Sbjct: 1796 KVESLLNEMKELDSKLHLQEV---QLMTKI-EACIELEKIVGELKKENSDLSEKLEYFSC 1851

Query: 303  KNQTLTENLLKKEQDYTKLE---EKHNEESVSKK--NIQATLHQKDLDCQQLQSRLSASE 357
             +Q L + +   E   + LE   +K + E +      +  +  ++ LD +   SR+ + +
Sbjct: 1852 DHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEK 1911

Query: 358  TSLHR--IHVE------------LSEKGEATQK----LKEELSEVETKYQHLKAEFKQLQ 399
             S+    +++E            L +  E  QK    L+EELS V ++   L+ E   + 
Sbjct: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971

Query: 400  QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD-- 457
            ++    +Q   +++ +  +L S   E    +  A   +KE+ +L      D  + + D  
Sbjct: 1972 KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT 2031

Query: 458  -LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
             LQ KL  LE+  +       EL++Q+ +  ++ +      +S  A+L E+  +   V +
Sbjct: 2032 HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSK 2091

Query: 517  QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE----TAVLNQLQEKNHT 572
             +     +       L  ++E +  L +  E L  +I+A E +       L + + +N +
Sbjct: 2092 ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS 2151

Query: 573  LQEQVTQLTEKLK----NQ------SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
            L+++V  L  +L+    NQ      +E+ K   E L  Q++E    L+  +  +++L + 
Sbjct: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE 2211

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
               L  Q+ E + ++S+LD  + +   LL   E A+      ++    TA   LQ++ +E
Sbjct: 2212 KENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI----QIKEESKTAVEMLQNQLKE 2267

Query: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
            LN       +  A L   QE     E  L    E+   L    E+L  +++  E   L V
Sbjct: 2268 LN-------EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCV 2320

Query: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
                   LQ L++       L+ R   L ++LE+ +       L+ +     +E++K K+
Sbjct: 2321 -------LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373

Query: 803  TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
                +  + L+ D  T+  E +    EL    Q  ++EL+ +    E ++ E    K ++
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQEKVQM 2432

Query: 863  SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
             + S +         KE  +  AA+ + ++ CK  +  L  Q+E    E+ +L + L++ 
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492

Query: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
            K     L+  +N + +++   +  L++ ++E  +L+  I    Q  EQ   ++  ++GE 
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI----QDQEQLVSKLSQVEGEH 2548

Query: 983  KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
            ++   Q  EL N L  +L Q          KI VLQ+     Q+T + LQS +   E+EL
Sbjct: 2549 QLWKEQNLELRN-LTVELEQ----------KIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
              T+ D  S  EK+                 NK+     TAK T      + ++++ E  
Sbjct: 2598 ELTKMDKMSFVEKV-----------------NKM-----TAKET------ELQREMHEMA 2629

Query: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE--KEITKLNEELKS-----HKLESI 1155
            +   ++Q+E S ++  L  E   L  +EEIK  ++  KE+T  N ELK      HK +  
Sbjct: 2630 QKTAELQEELSGEKNRLAGELQLL--LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVE 2687

Query: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL---KKEFI 1212
            KE       ++ + + +L L           E EK++Q +L D  K+ E E+   +++  
Sbjct: 2688 KE----GKVREEIAEYQLRLH----------EAEKKHQALLLDTNKQYEVEIQTYREKLT 2733

Query: 1213 EKEAKLHSEIKEKEVGMKKHEE--NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
             KE  L S+  E ++     EE  N  K T QI      L  +KK    + + V++L+K+
Sbjct: 2734 SKEECLSSQKLEIDLLKSSKEELNNSLKATTQI------LEELKKTKMDNLKYVNQLKKE 2787

Query: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
             +  +G++ +L  + +  ++E+  L +   + +   EK +T  + +  K+D  T  ++EL
Sbjct: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV-MDTKVDELTTEIKEL 2846



 Score =  182 bits (463), Expect = 2e-45
 Identities = 279/1351 (20%), Positives = 568/1351 (42%), Gaps = 159/1351 (11%)

Query: 90   QEVQDLQASLKEEKWYSEELKKELEKYQG-LQQQEAKPDGLVTDSS------AELQSLEQ 142
            Q++Q+L+  L + K   ++ + +L+  +  LQ+Q+ K +   T+ +        L  + +
Sbjct: 18   QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77

Query: 143  QLEEAQ---TENFNIKQMKDLFEQ--------KAAQLATEIADIKSKYDEERSLREAAE- 190
             LE+ +   +    +K+ +  F++        +  +L  E+   KS+ +  +   ++A+ 
Sbjct: 78   SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137

Query: 191  --------QKV--TRLTEELNKEATVIQDLK------TELLQRPGIEDVAVLKKELVQV- 233
                    QK+  T LT       +  +DLK       E  +R   E  A+  K+  Q  
Sbjct: 138  SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197

Query: 234  -QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELA----KGPQEVAVYVQ 288
             Q  M++  + R + S  +    ++    + SS +  + +R + +     G QEV     
Sbjct: 198  PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257

Query: 289  ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348
             LQ  K   N     N +    L     D  K + +     +++  ++   H+K++  Q 
Sbjct: 258  TLQIGKRDANSSFFDNSSSPHLL-----DQLKAQNQELRNKINELELRLQGHEKEMKGQV 312

Query: 349  LQSRLSASETSLHRIHVELSEKGEATQKLKEEL-------SEVETKYQHLKAEFKQLQQ- 400
              ++    +  L +  VEL EK +   K ++EL        +  TKY  L+ + K+L + 
Sbjct: 313  --NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTED 370

Query: 401  ---QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457
               QR+  E     L+ +I +   +  E   +   +   L ++      +L  + QQ  +
Sbjct: 371  LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKN 430

Query: 458  ----LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
                LQ +L +L    ++   N  E + +L + +Q  Q  Q  +      + E + +   
Sbjct: 431  MHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490

Query: 514  VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
            +      K +++ +LEA L+  K+ ++  +   E++ AK  + E    +L  LQEK   +
Sbjct: 491  LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE---TMLRDLQEK---I 544

Query: 574  QEQVTQLT-EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
             +Q   LT EKLK      ++ ++   D +++++ H+    D++   E     L S L  
Sbjct: 545  NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL 604

Query: 633  SKEKVSQLDIQI------KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
             K++  +L  +       K++ E LL+   ++        NHL+T     Q K  E N+ 
Sbjct: 605  KKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER 664

Query: 687  --TTQLDQVTAKLQDKQEHCSQLES---HLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
              T ++D+    ++ +  H + L+S    ++  K  Y+ L+QK E  + + +K E +++ 
Sbjct: 665  VRTLEMDRENLSVEIRNLH-NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK-EIENMC 722

Query: 742  VKASKEQA-LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
            +K S+    ++DL+ + QL ++  +      + L  E E +     DL K  +A      
Sbjct: 723  LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR----DLLKSKDA-----S 773

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
             +T ++ ++ +L  D          Q   +++     + E   +  E+     E     D
Sbjct: 774  LVTNEDHQRSLLAFD----------QQPAMHHSFANIIGEQGSMPSERSECRLEA----D 819

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
            +  K S  L+N     E   +  K    DL+K C+EL  Q++ ++E  L + +++ +S  
Sbjct: 820  QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV-QIKGEIEENLMKAEQMHQSFV 878

Query: 921  KE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL-------QGNINELKQSS---E 969
             E  +   +L+ + ++ Q  + +  + L+  EKE Q L       Q  I ELK+S+   E
Sbjct: 879  AETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE 938

Query: 970  QKKKQIEALQGELK--------IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN-- 1019
               K+++ L   L         I  L K E+E   Q+  T      +  +EK++++Q   
Sbjct: 939  DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSE 998

Query: 1020 ---NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
               NY   +E      SD Y +E  +L  R       E+   A EDL         +N  
Sbjct: 999  SFANYIDEREKSISELSDQYKQEKLILLQRC------EETGNAYEDLSQKYKAAQEKNSK 1052

Query: 1077 IQELKTAKATLEQDSAKKEQQLQER-CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135
            ++ L     +L ++   + +QL+E   K  Q+   + +  E+     ++ + E+E ++  
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER---NQNLMLELETVQQA 1109

Query: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
               E+T      KS      +EI  LK+ +  + ++  +L  + + L   ++ +   Q +
Sbjct: 1110 LRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL 1169

Query: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
              + ++   +E + E  +   K   +++ KE+ +  +         Q+  L   L   + 
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY-------NAQLVQLEAMLRNKEL 1222

Query: 1256 EWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERC--------LKGEGEIE 1307
            + Q S++    L+ +   +RG++    + +Q+ Q +  + L+ C        + G  E+ 
Sbjct: 1223 KLQESEKEKECLQHELQTIRGDLET--SNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280

Query: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
              Q     LQ  L  T   + EL +  + LQ
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQ 1311



 Score =  168 bits (425), Expect = 4e-41
 Identities = 289/1451 (19%), Positives = 579/1451 (39%), Gaps = 226/1451 (15%)

Query: 55   ELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE 114
            EL    +A+     D+ +  +S     + ++  L++E   +Q  + +    +E+L K ++
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK 1161

Query: 115  KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK-DLFEQKAAQLATEIA 173
                 Q  E++P   + +S  E +S   Q       +  +K++  D +  +  QL   + 
Sbjct: 1162 TKHECQNLESEP---IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218

Query: 174  DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV-- 231
            + + K  E    +E  + ++  +  +L  E + +QD++++ +   G++D  +  +E    
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDL--ETSNLQDMQSQEIS--GLKDCEIDAEEKYIS 1274

Query: 232  ---QVQTLMDN---------MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG 279
               ++ T  ++          T+ +  E EK+   C+ LQ++       ++  RSE    
Sbjct: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKI---CEILQAEKYELVTELNDSRSECITA 1331

Query: 280  PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339
             +++A   +E+ KL + V  L   +  L   L+         E+    E   + N Q  +
Sbjct: 1332 TRKMA---EEVGKLLNEVKILNDDSGLLHGELV---------EDIPGGEFGEQPNEQHPV 1379

Query: 340  HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
                LD       L+ S+  +     EL EK      L+ E   +  ++  + ++  +LQ
Sbjct: 1380 SLAPLDESNSYEHLTLSDKEVQMHFAELQEK---FLSLQSEHKILHDQHCQMSSKMSELQ 1436

Query: 400  QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE------- 452
               +  +   L L + +      L++ E QLG   G +     LSS  + D         
Sbjct: 1437 TYVDSLKAENLVLSTNLRNFQGDLVK-EMQLGLEEGLVPS---LSSSCVPDSSSLSSLGD 1492

Query: 453  --------QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
                    +Q  D+ L LS LE  +     N   +      + Q+    +    S  AK 
Sbjct: 1493 SSFYRALLEQTGDMSL-LSNLEGAVS---ANQCSVDEVFCSSLQEENLTRKETPSAPAKG 1548

Query: 505  REAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENIS-LLEKEREDLYAKIQAGEGETAV 562
             E    L +V RQ  +K ++K+++   +  K  + +  LL  ER++L            +
Sbjct: 1549 VEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL----------DCL 1598

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA----------- 611
              Q   +N   Q+++T +T +++++  + K+  E L  +++  +  L+            
Sbjct: 1599 RKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658

Query: 612  -AQDRVLSLETSVNELNSQLNESKEKVSQLDIQ----------IKAKTELLLSAEAAKTA 660
              +D +     S +      +E+ E+  + D+           +    E +    A K  
Sbjct: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPT 1718

Query: 661  QRADLQNHLDT-----------------------AQNALQD-----KQQELNKITTQLDQ 692
                 +   DT                         NAL        Q++++ +  ++ +
Sbjct: 1719 GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKE 1778

Query: 693  VTAK-------LQDKQEHCSQLESHLKEYKEKYLSLEQ-----------KTEELEGQIKK 734
             + +       ++D+      L + +KE   K L L++           + E++ G++KK
Sbjct: 1779 TSNENLRLLHVIEDRDRKVESLLNEMKELDSK-LHLQEVQLMTKIEACIELEKIVGELKK 1837

Query: 735  LEADSLE----VKASKEQALQDLQQQRQLNTDLELRATELSKQ-----LEMEKEIVSSTR 785
              +D  E         ++ LQ ++    LN+DLE+ A + S++     +    +      
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF 1897

Query: 786  LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT---ELQ 842
            LD++ +   + S K  +   E E   L+ D E +  E     ++  N+ +  V    EL 
Sbjct: 1898 LDVENELSRIRSEKASI---EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954

Query: 843  KVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
             V  E+  L  EL T+  K   L ++S+ +K    E E    +    I   E   KE   
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTE 2014

Query: 900  QLQV---QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
             LQ     +   LK++  L++ L+  ++ S  L L    ++ Q+ Q     +   KE + 
Sbjct: 2015 LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074

Query: 957  LQGNINELKQSSEQKKKQIEAL---QGE--LKIAVLQ---------------KTELENKL 996
            LQ  ++E         K +EA    +GE  L+++  Q               + E + K 
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134

Query: 997  QQQLTQAAQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
            Q  + +  +E   E    K+K+  L+   + S+E  + +  D    ++E+   +  ++ +
Sbjct: 2135 QLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEM 2194

Query: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
               L + + DL++ R++  N  K IQE +   + L++  +  +  L+E+ +A   I++E 
Sbjct: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEES 2254

Query: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL------KSHKL----ESIKEITNLK 1162
                + L N+  +L E     C  ++EI K  E+       + H+L    E ++      
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALC-GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEAD 2313

Query: 1163 DAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE 1221
            + KQL + Q+L E +  AD LK  VE  +R  +I +    +E   L+ E  + E +    
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR--TNQEHAALEAENSKGEVE---T 2368

Query: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
            +K K  GM    ++   L + +  +      +  E Q  Q R+SELE             
Sbjct: 2369 LKAKIEGM---TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS-------F 2418

Query: 1282 EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL-------DNTTAAVQELGREN 1334
            E  +Q  + E+  + E   K    +E LQT++ EL  ++       +   A  Q L  + 
Sbjct: 2419 ENILQEKEQEKVQMKE---KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475

Query: 1335 QSLQIKHTQAL 1345
            + L+++  Q L
Sbjct: 2476 ECLELEKAQLL 2486



 Score =  164 bits (414), Expect = 7e-40
 Identities = 252/1102 (22%), Positives = 466/1102 (42%), Gaps = 161/1102 (14%)

Query: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-LSEKGEAT 374
            Q   KLEEK   + + K            + Q+L+  LS+    L  +  + LSE  +  
Sbjct: 1561 QSLEKLEEKMESQGIMKNK----------EIQELEQLLSSERQELDCLRKQYLSENEQWQ 1610

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL-LETERQL--- 430
            QKL     E+E+K   L AE KQ +Q   E E   LQLQ       S L ++TE  +   
Sbjct: 1611 QKLTSVTLEMESK---LAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGR 1667

Query: 431  GEAHGRLKEQRQLSSEK--------LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
             E+    KE    ++E+        + DK+ Q  DL L + ++ E    K T     +  
Sbjct: 1668 NESCDISKEHTSETTERTPKHDVHQICDKDAQ-QDLNLDIEKITETGAVKPTGECSGEQS 1726

Query: 483  LDKTKQQHQEQQALQQSTTA----------------------------KLREAQNDLEQV 514
             D   +   E +    S                               +++E  N+  ++
Sbjct: 1727 PDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786

Query: 515  LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
            L  I D+D+K+   E+LL + KE  S L  +   L  KI+A      ++ +L+++N  L 
Sbjct: 1787 LHVIEDRDRKV---ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLS 1843

Query: 575  EQV-------------TQLTEKLKNQSESH--KQAQENLHDQVQEQKAHLRAAQDRVLSL 619
            E++              + +E L +  E H  K ++E++ D V +     +   +R L +
Sbjct: 1844 EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK---ERFLDV 1900

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKA-KTELLLSAEAAKTAQRAD--LQNHLDTA---Q 673
            E  ++ + S+    + +   L+  ++  +TE L   +  +  Q+    L+  L      +
Sbjct: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSER 1960

Query: 674  NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
            N L+ +   ++K TT LDQ++ K+++K +   +LESH  E        E + +E    ++
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQ---ELESHQSECLHCIQVAEAEVKEKTELLQ 2017

Query: 734  KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ---LEMEKEIVSSTRLDLQK 790
             L +D  E+   K    + LQ   + +  L L   EL  Q   L  EKE+       L K
Sbjct: 2018 TLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-------LVK 2070

Query: 791  KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
            +SE+L++   +L++ + EK  + +  E       ++  E   R+ +T  E+ +++   E 
Sbjct: 2071 ESESLQA---RLSESDYEKLNVSKALEA----ALVEKGEFALRLSSTQEEVHQLRRGIEK 2123

Query: 851  LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV-QMENTL 909
            L   +   + K   +++ LK  + E E ++ K K   L+ E    E   +L +   EN+ 
Sbjct: 2124 LRVRIEADEKKQLHIAEKLK--ERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181

Query: 910  KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN-EKEEQQLQGNINEL-KQS 967
             E + LK  +E+   +    +L+L +++ +        K+N  K+ Q+ QG ++EL K  
Sbjct: 2182 AEVETLKTQIEEMARSLKVFELDLVTLRSE--------KENLTKQIQEKQGQLSELDKLL 2233

Query: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQ--QLTQAAQELAAEKEKISVLQNNYEKSQ 1025
            S  K    E  Q E++I    KT +E    Q  +L +A   L  ++E +   + + +   
Sbjct: 2234 SSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI 2293

Query: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE--DLISNRNQIGNQNKLIQELKTA 1083
            E   QL++      + L A  +    V ++L  ++   DL+  R +   +   I      
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353

Query: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK-ELVNEKSKLAEIEEIKCRQEKEITK 1142
             A LE +++K E +               +LK K E + +  +  E++ +  R EKE   
Sbjct: 2354 HAALEAENSKGEVE---------------TLKAKIEGMTQSLRGLELDVVTIRSEKE--N 2396

Query: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
            L  EL+  + E I E+  +  + + ++Q+K              EQEK   +       +
Sbjct: 2397 LTNELQKEQ-ERISELEIINSSFENILQEK--------------EQEKVQMKEKSSTAME 2441

Query: 1203 EEEELKKEFIEKEAKLHSE---IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
              +   KE  E+ A LH++    K KE  +    E    L ++   L + L   K  +  
Sbjct: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC---LELEKAQLLQGLDEAKNNYIV 2498

Query: 1260 SQRRVSELEKQTDDLRGEIAVLEATV---QNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
             Q  V+ L ++ +D + ++   +  +   +N   ++  L+ +  + EGE +  + + LEL
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558

Query: 1317 QRKLDNTTAAVQELGRENQSLQ 1338
            +         +Q L  +N SLQ
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQ 2580



 Score =  150 bits (379), Expect = 8e-36
 Identities = 234/1162 (20%), Positives = 481/1162 (41%), Gaps = 174/1162 (14%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            E+NL   +  +    Q  Q  Q    E +   EE+KKE    +   +Q+A+    V    
Sbjct: 450  ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE---VCHLE 506

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
            AEL++++Q L   Q++NF  ++MK     K     T + D++ K +++ +      +K+ 
Sbjct: 507  AELKNIKQCLN--QSQNF-AEEMK----AKNTSQETMLRDLQEKINQQEN--SLTLEKLK 557

Query: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
                +L K+    QDL               LKK               RE   E+L D+
Sbjct: 558  LAVADLEKQRDCSQDL---------------LKK---------------REHHIEQLNDK 587

Query: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
              K + +   S+A +S L  EL K   E      EL++ K+  +    +N+ L   L + 
Sbjct: 588  LSKTEKE---SKALLSAL--ELKKKEYE------ELKEEKTLFSCWKSENEKL---LTQM 633

Query: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
            E +   L+ K N      K  Q   H+ +   + L+         +  +H  L  K    
Sbjct: 634  ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS--- 690

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
                    EVET+    K  + +LQQ+ E  +Q   + Q EI  +    L+T +  G+  
Sbjct: 691  -------VEVETQ----KLAYMELQQKAEFSDQ---KHQKEIENM---CLKTSQLTGQVE 733

Query: 435  GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQHQL--DKTKQ 488
              L+ + QL S ++MDK++   DL  +   L + LK K    VTN    +  L  D+   
Sbjct: 734  D-LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA 792

Query: 489  QHQEQQAL---QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
             H     +   Q S  ++  E + + +Q  +       ++ +LE  L+  K+  S L+K+
Sbjct: 793  MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852

Query: 546  REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
             E+L  +I+ GE E  ++ + ++ + +   + +Q   KL+  + +H+         ++ +
Sbjct: 853  CEEL-VQIK-GEIEENLM-KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909

Query: 606  KAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
            +  L+   D+V + +  + EL   N  L +S +++  L   +  + + + S  +    + 
Sbjct: 910  EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
             +L     T +       QE   +  + +     + ++++  S+L     +YK++ L L 
Sbjct: 970  EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSD---QYKQEKLILL 1026

Query: 723  QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
            Q+ EE     + L   S + KA++E+           N+ LE    E +   E  K    
Sbjct: 1027 QRCEETGNAYEDL---SQKYKAAQEK-----------NSKLECLLNECTSLCENRK---- 1068

Query: 783  STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
                        LE +K+   K+ +E        E  +Q   ++ E +   +++ +T+ Q
Sbjct: 1069 ----------NELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQ 1118

Query: 843  -KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
               K E   L  E+ T+K++ +K+   + +   E E+        ++ + KT  E ++  
Sbjct: 1119 NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ--------LMKVMKTKHECQNLE 1170

Query: 902  QVQMENTLKEQKELKKSLEKEKEASHQLK-LELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
               + N++KE++  +     + +   ++K + L+S   QL+Q +  L+  E +       
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK------- 1223

Query: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
            + E ++  E  + +++ ++G+L+ + LQ  +            +QE++  K+     +  
Sbjct: 1224 LQESEKEKECLQHELQTIRGDLETSNLQDMQ------------SQEISGLKDCEIDAEEK 1271

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
            Y          Q+D    +  L  T   L  +E+   + Q +          + +L+ EL
Sbjct: 1272 YISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE----------KYELVTEL 1321

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV------------NEKSKLAE 1128
              +++     + K  +++ +    ++ +  +  L   ELV            NE+  ++ 
Sbjct: 1322 NDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSL 1381

Query: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1188
                +    + +T  ++E++ H  E  ++  +L+   ++L  Q  ++  K   L+  V+ 
Sbjct: 1382 APLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441

Query: 1189 EKRNQQILKDQVKKEEEELKKE 1210
             K    +L   ++  + +L KE
Sbjct: 1442 LKAENLVLSTNLRNFQGDLVKE 1463



 Score =  149 bits (377), Expect = 1e-35
 Identities = 205/937 (21%), Positives = 420/937 (44%), Gaps = 112/937 (11%)

Query: 478  ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ---IGDKDQKIQNLEALLQK 534
            EL+ QLDK K++ Q++Q    S  A L++ +  +E    +   +  ++Q++  +   L+K
Sbjct: 22   ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEK 81

Query: 535  SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA 594
            +K+ IS   + +E   +++   EG+   LN  +++   L++++ +   +L+   ++ + A
Sbjct: 82   TKQKISHELQVKE---SQVNFQEGQ---LNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135

Query: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
              +L+     QK              +   +L  + N+  E+  +L+ ++KA    L + 
Sbjct: 136  DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA----LQAK 191

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
            +A++T  +A + NH D A++     Q   +  + Q ++  + L       SQ     +++
Sbjct: 192  KASQTLPQATM-NHRDIARH-----QASSSVFSWQQEKTPSHLSSN----SQRTPIRRDF 241

Query: 715  KEKYLSLEQKTEELEG--QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
               Y S EQ+        QI K +A+S     S    L D  Q +  N +L  +  EL  
Sbjct: 242  SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD--QLKAQNQELRNKINELEL 299

Query: 773  QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
            +L+  ++ +       Q+    LE  K +L   E+EK + K   E +   T  Q+++ + 
Sbjct: 300  RLQGHEKEMKGQVNKFQELQLQLEKAKVELI--EKEKVLNKCRDELV--RTTAQYDQAST 355

Query: 833  RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
            +   T  E QK+K   E L  +    +     +   +K  + EF++E  + + +   L++
Sbjct: 356  KY--TALE-QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412

Query: 893  TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
             C ++K +L  +++        L+  L+K      QL+  L   +++L +A+   + ++ 
Sbjct: 413  ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI 472

Query: 953  EEQQLQGNINE-------LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA-- 1003
            +E +L+ ++ E       LK  SEQK +++  L+ ELK            ++Q L Q+  
Sbjct: 473  KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK-----------NIKQCLNQSQN 521

Query: 1004 -AQELAAEKEKISVLQNNYEKSQET-FKQLQSDFYGRESELLATRQDLKSVE-EKLSLAQ 1060
             A+E+ A+             SQET  + LQ     +E+ L   +  L   + EK     
Sbjct: 522  FAEEMKAK-----------NTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS 570

Query: 1061 EDLISNRNQIGNQ--NKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQKEKSLK-- 1115
            +DL+  R     Q  +KL +  K +KA L   +  KKE +  +  K L    K ++ K  
Sbjct: 571  QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630

Query: 1116 ---EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE------SIKEITNLKDAKQ 1166
               E E  N +SK+  +E     Q+ +  + NE +++ +++       I+ + N+ D+K 
Sbjct: 631  TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690

Query: 1167 LLIQ-QKL---ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK-------KEFIEKE 1215
            + ++ QKL   ELQ KA+      ++E  N  +   Q+  + E+L+        E ++K+
Sbjct: 691  VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 1216 ---AKLHSE-------IKEKEVGMKKHEENEAKLTM--QITALNENLGTVKKEWQSSQRR 1263
                 LH+E       +K K+  +  +E+++  L    Q  A++ +   +  E  S    
Sbjct: 751  RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810

Query: 1264 VSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT 1323
             SE   + D      A+L    QN  D     LE   +   +++K   ++++++ +++  
Sbjct: 811  RSECRLEADQSPKNSAIL----QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN 866

Query: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMA 1360
                +++   +QS   + +Q +++   + +  QN +A
Sbjct: 867  LMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVA 900



 Score =  129 bits (323), Expect = 3e-29
 Identities = 285/1451 (19%), Positives = 590/1451 (40%), Gaps = 240/1451 (16%)

Query: 61   EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
            E   D   D     E ++    D ++   +E + L ++L+ +K   EELK+E   +   +
Sbjct: 564  EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623

Query: 121  QQEAKPDGLVTDSSAELQSLEQQLEEAQT-----------------------ENFN--IK 155
             +  K   L+T   +E ++L+ ++   +T                       EN +  I+
Sbjct: 624  SENEK---LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680

Query: 156  QMKDLFEQKAAQLATE-----IADIKSKYDEERSLREAAEQ--KVTRLTEELNKEATVIQ 208
             + ++ + K+ ++ T+         K+++ +++  +E      K ++LT ++      +Q
Sbjct: 681  NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740

Query: 209  DLKTELLQRPG-IEDVAVLKKELVQVQTLMDNMTLERERESEKLK--DECKKLQSQYA-- 263
             L  E++ +    +D+    + L  +    D   +  E     L   D+   +   +A  
Sbjct: 741  LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800

Query: 264  -----SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
                 S  +  S+ R E  + P+  A+    +  L+ S+    Q N  L +   +  Q  
Sbjct: 801  IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIK 860

Query: 319  TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
             ++EE   +     ++  A   Q+     +LQ   SA +  +      L  K +  Q L 
Sbjct: 861  GEIEENLMKAEQMHQSFVAETSQR---ISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917

Query: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE---AHG 435
            +++   + + Q LK     L+   +E +     L  E  ++ S +   +R++ E    +G
Sbjct: 918  DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977

Query: 436  RLKE-QRQLSSEK--LMDKEQQVA----DLQLKLSRLEEQLK----------EKVTNSTE 478
             LKE    L+ EK  L+ K +  A    + +  +S L +Q K          E+  N+ E
Sbjct: 978  TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYE 1037

Query: 479  -LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
             L  +    ++++ + + L    T+     +N+LEQ+      + Q+     A  ++  +
Sbjct: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097

Query: 538  NISL-LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
            N+ L LE  ++ L +++   +      N   E     QE +T   E+ K Q E +   QE
Sbjct: 1098 NLMLELETVQQALRSEMTDNQN-----NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152

Query: 597  NLHDQVQEQKAHLRAAQDRVLSLET-----SVNELNSQLNESKEKVSQLDIQIKAKTELL 651
            N      EQ   +   +    +LE+     SV E  S+ N+   K  Q+D+++K   E+ 
Sbjct: 1153 N------EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFK-PQMDLEVK---EIS 1202

Query: 652  LSAEAAKTAQ-RADLQNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQEHCSQL 707
            L +  A+  Q  A L+N     Q + ++K   Q EL  I   L+  T+ LQD Q   SQ 
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNLQDMQ---SQE 1257

Query: 708  ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
             S LK+ +   +  E+K      ++   + D+  ++ S +  +  L +  ++   L+   
Sbjct: 1258 ISGLKDCE---IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314

Query: 768  TELSKQL-EMEKEIVSSTRLDLQKKSEALESIK--------------------------- 799
             EL  +L +   E +++TR   ++  + L  +K                           
Sbjct: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374

Query: 800  ----------------QKLTKQEEEKQI----LKQDFETLSQETKIQHEELNNRIQTTVT 839
                            + LT  ++E Q+    L++ F +L  E KI H++ + ++ + ++
Sbjct: 1375 EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ-HCQMSSKMS 1433

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG--KAAILDLEKTCKEL 897
            ELQ          T + ++K +   +S +L+N + +  KE Q G  +  +  L  +C   
Sbjct: 1434 ELQ----------TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD 1483

Query: 898  KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE--------------LNSMQEQLIQA 943
               L     ++L +    +  LE+  + S    LE               +S+QE+ +  
Sbjct: 1484 SSSL-----SSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTR 1538

Query: 944  QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
            + T     K  ++L+      +QS E+ ++++E+ QG +K   +Q+ E            
Sbjct: 1539 KETPSAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQELE------------ 1585

Query: 1004 AQELAAEKEKISVLQNNYEKSQETFKQ-LQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
             Q L++E++++  L+  Y    E ++Q L S     ES+L A ++  + +  +L +A+  
Sbjct: 1586 -QLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQ 1644

Query: 1063 L----ISNRNQIG--NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK- 1115
            L    +S+R+ +G   ++ +    ++   + E  S   E+  +     + D   ++ L  
Sbjct: 1645 LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNL 1704

Query: 1116 EKELVNEKSKLAEIEEIKCRQEKEIT--KLNEELKSHKLESIKEIT-------------- 1159
            + E + E   +    E    Q  +       E+      E I E++              
Sbjct: 1705 DIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLG 1764

Query: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
            N +D   L ++ K E   +   L   +E   R  + L +++K+ + +L  + ++   K+ 
Sbjct: 1765 NQEDIHNLQLRVK-ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE 1823

Query: 1220 SEIK-EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD-----D 1273
            + I+ EK VG  K E ++    ++  + +     + +  ++S+   S+LE   D     D
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQ--ELLQRVETSEGLNSDLEMHADKSSRED 1881

Query: 1274 LRGEIAV-----------LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
            +   +A            +E  +   + E+ ++    L  E ++E +QT+ L L++  +N
Sbjct: 1882 IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN 1941

Query: 1323 TTAAVQELGRE 1333
                +  L  E
Sbjct: 1942 KQKVIVCLEEE 1952



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 80/426 (18%), Positives = 188/426 (44%), Gaps = 38/426 (8%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            ++N  + +  V  L QEV+D +  L+++      LK +++  + L  + ++ +G      
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG------ 2546

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
             E Q  ++Q  E +     ++Q   + + K A L   +  ++S Y    +  E  +    
Sbjct: 2547 -EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKM 2605

Query: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
               E++NK      +L+ E+ +    +  A L++EL   +  +         E +  KD+
Sbjct: 2606 SFVEKVNKMTAKETELQREMHEM--AQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663

Query: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
             K+L  + +  + ++  +  +  +   +V    +E+ + +  ++E  +K+Q L  +  K+
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVR---EEIAEYQLRLHEAEKKHQALLLDTNKQ 2720

Query: 315  -EQDYTKLEEK--HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371
             E +     EK    EE +S + ++  L +     ++L + L A+   L  +     +  
Sbjct: 2721 YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK--EELNNSLKATTQILEELKKTKMDNL 2778

Query: 372  EATQKLKEELSEVETKYQHLKAEFKQLQQQRE-------------EKEQHGLQLQSEINQ 418
            +   +LK+E    + K + L    KQL++++E             EK++ G  + +++++
Sbjct: 2779 KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDE 2838

Query: 419  LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
            L +++ E +  L        E++   +++ +DK   +     KL + +E L+ +V +   
Sbjct: 2839 LTTEIKELKETL--------EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCS 2890

Query: 479  LQHQLD 484
             Q + D
Sbjct: 2891 QQSKQD 2896



 Score = 40.0 bits (92), Expect = 0.016
 Identities = 59/249 (23%), Positives = 106/249 (42%), Gaps = 35/249 (14%)

Query: 58   KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
            K YE       +     E  L+ ++ ++ LL+   ++L  SLK      EELKK      
Sbjct: 2719 KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK------ 2772

Query: 118  GLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIK 176
                   K D L       +  L+++ E AQ +    IK  K L E+K   L  E++ ++
Sbjct: 2773 ------TKMDNL-----KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI-LQKELSQLQ 2820

Query: 177  SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236
            +  +++++     + KV  LT E       I++LK  L ++    D  + K        L
Sbjct: 2821 AAQEKQKT-GTVMDTKVDELTTE-------IKELKETLEEKTKEADEYLDK----YCSLL 2868

Query: 237  MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
            + +  LE+ +  E L+ +   L SQ +  ++  S L   +  GP  +    +  ++L S 
Sbjct: 2869 ISHEKLEKAK--EMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTE--KRLSSG 2924

Query: 297  VNELTQKNQ 305
             N+ + K Q
Sbjct: 2925 QNKASGKRQ 2933


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  210 bits (535), Expect = 7e-54
 Identities = 286/1401 (20%), Positives = 614/1401 (43%), Gaps = 165/1401 (11%)

Query: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
            L+  ++  LR + + L   L E     ++LK E  +      Q ++ +G ++    E  S
Sbjct: 273  LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332

Query: 140  LEQQLEEAQTE--NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
              QQL++A  E    + K  ++  E K AQL  E++             E  + K+++L 
Sbjct: 333  HLQQLQDALNELTEEHSKATQEWLE-KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391

Query: 198  EELNK--------EATVIQD-LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
            E L++        +  V+ D L+ E L+    ++ A L     Q+Q  ++ +  ER ++ 
Sbjct: 392  EHLSQLQDNPPQEKGEVLGDVLQLETLK----QEAATLAANNTQLQARVEMLETERGQQE 447

Query: 249  EKL----------KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN 298
             KL          K +   L +   SS + +SQ + EL +  Q          +L + V 
Sbjct: 448  AKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA------RLTAQVA 501

Query: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASET 358
             LT +  TL   + +++Q+   L+++  E+      +  TL Q++   Q L+ ++    +
Sbjct: 502  SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ---LAQTLQQQEQASQGLRHQVEQLSS 558

Query: 359  SLHRIHVEL---SEKGEAT-----QKLKEELSEVETKYQHLKAEFKQLQQQREEKE---- 406
            SL +   +L   +EK EAT     Q+L     E E   +   A  KQL+   +EK     
Sbjct: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618

Query: 407  --QHGLQLQSEI-NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
              Q  LQ+ +E  +   + + + +R+  E   +++E +      +    Q+  + Q +++
Sbjct: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC----VETARQEQHEAQAQVA 674

Query: 464  RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
             LE QL+ +   +TE +    +  Q  ++ QAL++S        + +  +    + ++ +
Sbjct: 675  ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734

Query: 524  KIQNLEA----LLQKSKENISLLEKER---EDLYAKIQ----AGEGETAVLN----QLQE 568
             I  L+A    L+++ K     LE+ER   + L A++Q    A + ET VL     +   
Sbjct: 735  CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794

Query: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
              HT + +  QL +++    E ++ +Q       QE+  +    Q+++++L+    +   
Sbjct: 795  AQHTAESECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQEQLMTLKEECEKARQ 847

Query: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
            +L E+KEKV+     I++ +EL +S +  + A+   L  +L  A   +Q+K+    K+  
Sbjct: 848  ELQEAKEKVAG----IESHSELQISRQQNELAE---LHANLARALQQVQEKEVRAQKLAD 900

Query: 689  QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK----- 743
             L  +  K+    +  ++LE+ +++  E+  +  ++  +   +    + + LE +     
Sbjct: 901  DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960

Query: 744  ASKEQALQDLQQQ-RQLNTDLE-LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
             S + ALQ ++++  Q+  +LE LRA  +  Q + ++E     R ++ + ++     +  
Sbjct: 961  CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER-EVARLTQERGRAQAD 1019

Query: 802  LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM-TELSTVKD 860
            L  ++  +  L+   +    E +++   L   +   +TE +    E   L   E + +K+
Sbjct: 1020 LALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1079

Query: 861  --KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV------QMENTLKEQ 912
              +L +    LK   ++ EKE+  G  A  +     +    +L+       ++E   ++Q
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139

Query: 913  KELKKSLEKEKEASHQLKLE-------------------------LNSMQEQLIQAQNTL 947
            +E   SLE+  EA    + E                         L S Q +L   +  +
Sbjct: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199

Query: 948  KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE-----------------LKIAVLQKT 990
            + + K E + +  +   +Q +E+K   I +L+ E                 LK  V+ ++
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAES 1259

Query: 991  ELENKLQQQL-----------TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
            E   KL+++L            +AA+  +A +E++  L+   EK +   + L+ +   + 
Sbjct: 1260 EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 1319

Query: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
                   Q+LK+ +EK    ++ L + + +  +   L+ EL  AK   +Q  A++    +
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379

Query: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159
               + L+  ++       EL+  + +L E+  ++ ++  E  +  ++L++ K    ++++
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLR-QKVAEQERTAQQLRAEKASYAEQLS 1438

Query: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQE---KRNQQILKDQVKKEEEELKKEFIEKEA 1216
             LK A  LL ++   L  +A+  +  +E E    R + + +    + + E +   +++EA
Sbjct: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA 1498

Query: 1217 KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRG 1276
            +  S  +E EV   K+E  + K+  +     E    +  + +  +    E  KQ ++L  
Sbjct: 1499 Q--STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK 1556

Query: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336
            ++A  +   +  Q + +A+  +  + + E ++LQ ++ ELQ +L       +E   E+  
Sbjct: 1557 KLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-----KEQAAEHYK 1611

Query: 1337 LQIKHTQA-LNRKWAEDNEVQ 1356
            LQ++  +   + K  ++ E+Q
Sbjct: 1612 LQMEKAKTHYDAKKQQNQELQ 1632



 Score =  193 bits (490), Expect = 1e-48
 Identities = 297/1405 (21%), Positives = 590/1405 (41%), Gaps = 178/1405 (12%)

Query: 55   ELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEE------ 108
            E   H + + DA N+     E +    ++ +    Q  ++L A+L+++K   E+      
Sbjct: 329  EFASHLQQLQDALNELT---EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQG 385

Query: 109  -LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
             L +  E    LQ    +  G V     +L++L+Q+       N  ++   ++ E +  Q
Sbjct: 386  KLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 445

Query: 168  LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE------ 221
               ++   +  ++EE+       Q+++ L  +L    + +   K EL Q           
Sbjct: 446  QEAKLLAERGHFEEEK-------QQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498

Query: 222  DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281
             VA L  EL    T ++    ++++E   LK + K+ Q+Q A +     Q + + ++G +
Sbjct: 499  QVASLTSEL----TTLNATIQQQDQELAGLKQQAKEKQAQLAQT----LQQQEQASQGLR 550

Query: 282  EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY-----TKLEEKH---NEESVSKK 333
                   ++++L SS+ +  Q+ + + E      QD+     T  EE+     E   + K
Sbjct: 551  H------QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604

Query: 334  NIQATLHQKDLDCQQLQSRLSA----------SETSLHRIHVELSEKGEATQKL----KE 379
             ++A   +K    + LQ +L            S T   R   ELS K E  Q      ++
Sbjct: 605  QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ 664

Query: 380  ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE 439
            E  E + +   L+ + +  QQ+  EKE+    +  E +QL  +L   +  L    G L+E
Sbjct: 665  EQHEAQAQVAELELQLRSEQQKATEKER----VAQEKDQLQEQLQALKESLKVTKGSLEE 720

Query: 440  QRQLSSEKLMDKEQQVADLQLKLSRLEEQ-------LKEKVTNSTELQHQLDKTKQQHQE 492
            +++ +++ L ++++ +++L+ +   L EQ       L+E+      L+ +L +  + HQ 
Sbjct: 721  EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780

Query: 493  QQALQQSTTAKLREAQN----DLEQVLRQIG-------DKDQKIQNLEALLQKSKENISL 541
            +  + +   A+   AQ+    + EQ+++++        D  Q+     A+ Q   E +  
Sbjct: 781  ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ---EQLMT 837

Query: 542  LEKEREDLYAKIQAGEGETAVLN-----QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
            L++E E    ++Q  + + A +      Q+  + + L E    L   L+   E   +AQ+
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897

Query: 597  NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES-----KEKVSQLDIQIKAKTEL- 650
             L D +   +  + A    V  LET V +   Q   +     KE     D Q +   E  
Sbjct: 898  -LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQ 956

Query: 651  ---LLSAEAAKTAQRADLQ---NHLDTAQNALQDKQQELNKITTQLDQVTAKL-QDKQEH 703
                 S +AA  A   + +   N L+  + AL + Q +  +   Q ++  A+L Q++   
Sbjct: 957  GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRA 1016

Query: 704  CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE---ADSLEVKASKEQALQDLQ--QQRQ 758
             + L        E  + L+    E   +   L+   A +L  K  K+Q L  L+  +  Q
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076

Query: 759  LNTDLELRAT--ELSKQL-EMEKEIVSSTRLDLQKKSEA------LESIKQKLTKQEEEK 809
            +    ELR T  +L +QL + EKE  S +    +           LE+++ +++K E++ 
Sbjct: 1077 IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136

Query: 810  QILKQDFETLSQETKIQH----------EELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
            Q  ++  ++L +  + +           E L  +++    EL   +    +   EL+  +
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196

Query: 860  DKL---SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
             K+   SK  D  K   +   +E ++  + I  LE+    L  Q+ ++ E    E KELK
Sbjct: 1197 TKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV-LEKEG---ESKELK 1252

Query: 917  KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
            + +  E E S +L+  L  +Q +   A N+ +  E+    L+  +  L++ +E+++   E
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAET--ASNSARAAERSSA-LREEVQSLREEAEKQRVASE 1309

Query: 977  ALQGELKIAVLQKTELENKLQQ------QLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
             L+ EL     +  EL  +L+       Q  QA   L  E      L +    ++   +Q
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369

Query: 1031 LQSDFYGRES----ELLATRQDLKSVEEKLSLAQEDL---ISNRNQIGNQNKLIQELKTA 1083
            LQ++    E     EL  ++Q    +  +L  AQ +L   I  R ++  Q +  Q+L+  
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE 1429

Query: 1084 KATL-EQDSAKKEQQ--LQERCKALQD-IQKEKSLKEKELVNEKSK-LAEIEEIKCRQEK 1138
            KA+  EQ S  K+    L E  + L +     +   E EL   + K + E+  ++   E 
Sbjct: 1430 KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET 1489

Query: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ--------EK 1190
             + ++  E +S   E        + AK  +++++   Q +   L A VEQ         K
Sbjct: 1490 RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK 1549

Query: 1191 RNQQILK-----DQVKKEEEELKK-------EFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
            + +++ K     DQ  K +++  K       E  ++  +L +++ E +  + + E+    
Sbjct: 1550 QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEH 1609

Query: 1239 LTMQITALNENLGTVKKEWQSSQ---RRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
              +Q+     +    K++ Q  Q   R + +L+K+  +LR E   L   +Q    + +  
Sbjct: 1610 YKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA 1669

Query: 1296 LERCLKGEGEIEKLQTKVLELQRKL 1320
             + C     ++  L+ +V    ++L
Sbjct: 1670 EQTCRHLTAQVRSLEAQVAHADQQL 1694



 Score =  186 bits (473), Expect = 1e-46
 Identities = 253/1149 (22%), Positives = 497/1149 (43%), Gaps = 178/1149 (15%)

Query: 248  SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
            S + K E + L+ Q  +S ++ +   S     P    +   + Q ++    +L  +    
Sbjct: 172  SHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQ-MRRLKKQLADERSNR 230

Query: 308  TENLLKKEQDYTKLEEKHNEESVSKKNIQ--ATLHQKD----LDCQQLQSRLSASETSLH 361
             E  L+  ++   L EK  + ++ ++ I   A L++K     L+ ++L+     +E+   
Sbjct: 231  DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290

Query: 362  RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421
            R+H  L +     Q LK E S+++ K   L  E   L  +  E   H  QLQ  +N+L  
Sbjct: 291  RLHETLKQ----CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTE 346

Query: 422  KLLETERQLGEAHGRLKEQRQ--LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
            +  +  ++  E   +L+++    L  +K ++++ ++  LQ KLS+LEE L +        
Sbjct: 347  EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEI--LQGKLSQLEEHLSQ-------- 396

Query: 480  QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
                            LQ +   +  E   D    + Q+    Q+   L A   + +  +
Sbjct: 397  ----------------LQDNPPQEKGEVLGD----VLQLETLKQEAATLAANNTQLQARV 436

Query: 540  SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599
             +LE ER    AK+ A  G        +E+   L   +T L   + N S    QA+E L 
Sbjct: 437  EMLETERGQQEAKLLAERG------HFEEEKQQLSSLITDLQSSISNLS----QAKEELE 486

Query: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
               Q   A L A   +V SL + +  LN+ + +  ++++ L  Q K K   L      + 
Sbjct: 487  QASQAHGARLTA---QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543

Query: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
                 L++ ++   ++L+ K+Q+L ++  + +        +Q+H  QL +  +E      
Sbjct: 544  QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT------RQDHAQQLATAAEE------ 591

Query: 720  SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
              E    E +  +K+LEA    ++  K   L+ LQQQ Q+  +    A     Q + EK 
Sbjct: 592  -REASLRERDAALKQLEA----LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK- 645

Query: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
                   +L +K E L++  +   +++ E Q      +    E +++ E      Q   T
Sbjct: 646  ------AELSRKVEELQACVETARQEQHEAQA-----QVAELELQLRSE------QQKAT 688

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
            E ++V  EK+ L  +L  +K       +SLK +K   E+E ++   A+ + ++   ELK 
Sbjct: 689  EKERVAQEKDQLQEQLQALK-------ESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741

Query: 900  QLQVQMENTLKEQKEL------KKSLE---KEKEASHQLKLELNSMQEQLIQAQNTLKQN 950
            + +  +E   +E+KEL      +K LE   ++   +HQ + E+  ++ +L +A       
Sbjct: 742  ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEV--LRRELAEAMAAQHTA 799

Query: 951  EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
            E E +QL      +K+ +  +++  ++ Q E +   + + +L   L+++  +A QEL   
Sbjct: 800  ESECEQL------VKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEECEKARQELQEA 852

Query: 1011 KEKISVLQNNYE----KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
            KEK++ ++++ E    + Q    +L ++      ++       + + + LS  QE + + 
Sbjct: 853  KEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912

Query: 1067 RNQIGNQNKLI----QELKTAKATLEQDSAK---------KEQQLQERCK---ALQDIQK 1110
              ++     L+    ++ +TA   L ++ A+         +EQQ ++ C    ALQ +++
Sbjct: 913  SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972

Query: 1111 EKSLKEKELVNEKSKLAEI----EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166
            E      EL   ++ L E     +E + +QE+E+ +L +E    + +       L+ A +
Sbjct: 973  EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD-----LALEKAAR 1027

Query: 1167 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
              ++ +L+       ++ A  QE      L ++  K++E  K   +E      ++IKE E
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEAL-AHALTEKEGKDQELAKLRGLEA-----AQIKELE 1081

Query: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD-------LRGEIA 1279
                       +L   +  L E L   +KE  S     SE   +T+        LR E++
Sbjct: 1082 -----------ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130

Query: 1280 VLEATVQNNQDERRALLERCLKGE--------GEIEKLQTKVLELQRKLDNTTAAVQELG 1331
             LE   Q  Q++  + LER L+ E          +E LQ ++ E  ++L ++ +A+    
Sbjct: 1131 KLEQQCQKQQEQADS-LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189

Query: 1332 RENQSLQIK 1340
            RE  + + K
Sbjct: 1190 RELAAFRTK 1198



 Score =  181 bits (458), Expect = 6e-45
 Identities = 247/1274 (19%), Positives = 537/1274 (42%), Gaps = 200/1274 (15%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKP--------------------- 126
            LR +V+ L +SLK+++   ++LK+  EK +  +Q  A+                      
Sbjct: 549  LRHQVEQLSSSLKQKE---QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605

Query: 127  -DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
             + L  + +A+L+ L+QQL+ A     + +      +++ A+L+ ++ ++++  +  R  
Sbjct: 606  LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665

Query: 186  REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245
            +  A+ +V  L  +L  E     + +    ++  +++     KE ++V     ++  E+ 
Sbjct: 666  QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTK--GSLEEEKR 723

Query: 246  RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305
            R ++ L+++ + +    A + + + Q + E  +  +E A      + L++ + +L + +Q
Sbjct: 724  RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA----GRKGLEARLQQLGEAHQ 779

Query: 306  TLTENLLKKEQDYTKLEEKHNEESVSKKNIQ--ATLHQKDLDCQQLQSRLSAS-ETSLHR 362
              TE L ++  +   +  +H  ES  ++ ++  A   ++  D QQ +++  A  +  L  
Sbjct: 780  AETEVLRRELAE--AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQ-----------HLKAEFKQLQQQREEKEQHGLQ 411
            +  E  +  +  Q+ KE+++ +E+  +            L A   +  QQ +EKE    +
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897

Query: 412  LQSEINQLHSKLLETERQLGEAHGRLK---EQRQLSSEKLMDKEQQVAD----------- 457
            L  +++ L  K+  T +++      ++   EQ++ +S +L+ +  +  D           
Sbjct: 898  LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957

Query: 458  -----LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE----AQ 508
                  Q  L  +E + ++       L+  L +++ Q QE++  Q+   A+L +    AQ
Sbjct: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017

Query: 509  NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
             DL        + + ++QN    L + +   + L++       + +  + E A L  L+ 
Sbjct: 1018 ADLALEKAARAELEMRLQNA---LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA 1074

Query: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
                  E++ Q  ++LK Q    ++   +      E          ++ +L   V++L  
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQ 1134

Query: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
            Q  + +E+   L+  ++A+            A RA+  + L+T Q  L++K QEL     
Sbjct: 1135 QCQKQQEQADSLERSLEAER-----------ASRAERDSALETLQGQLEEKAQELGH--- 1180

Query: 689  QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
                        Q   +  +  L  ++ K     +  +E + Q+ +              
Sbjct: 1181 -----------SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR-------------- 1215

Query: 749  ALQDLQQQRQLNTDLELRATELSKQ-LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
              Q+ +++  L + LE   + L++Q LE E E     RL + +         +K  K EE
Sbjct: 1216 GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAES--------EKSQKLEE 1267

Query: 808  EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD 867
              ++L+ +  + S     +   L   +Q+   E +K ++  E L  EL++  ++  ++  
Sbjct: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ 1327

Query: 868  SLKNSKSEFEKENQKGKAAILDLEKTCKEL--------KHQLQVQMENTLKEQKELKKSL 919
             LK  + +F ++ Q    + L LE T  +         KH  Q         +K  ++ L
Sbjct: 1328 ELKAWQEKFFQKEQA--LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEL 1385

Query: 920  EKEKEASHQLKLELNSMQEQL---IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ-- 974
            E+ K+A+  L+ EL   Q +L   I  +  + + E+  QQL+       +     KK   
Sbjct: 1386 EQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG 1445

Query: 975  --IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE----KISVLQNNYEKSQETF 1028
               E  +G  + A L +  LE +L Q   +  QELAA +     +++ +Q   + +    
Sbjct: 1446 LLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505

Query: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
            + + + + G + ++L  RQ  +   +KL+   E L                        E
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL------------------------E 1541

Query: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL- 1147
                ++ +Q++E  K L D  +   +++++L   +++  E ++   R + ++ +L  +L 
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 1148 ------KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
                  + +KL+  K  T+  DAK+   QQ  ELQ +  SL               +Q++
Sbjct: 1602 QKEQAAEHYKLQMEKAKTHY-DAKK---QQNQELQEQLRSL---------------EQLQ 1642

Query: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261
            KE +EL+ E      +L  E+++  +  K+ E+    LT Q+ +L   +    ++     
Sbjct: 1643 KENKELRAE----AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ----L 1694

Query: 1262 RRVSELEKQTDDLR 1275
            R + + +  TD L+
Sbjct: 1695 RDLGKFQVATDALK 1708



 Score =  179 bits (455), Expect = 1e-44
 Identities = 245/1130 (21%), Positives = 470/1130 (41%), Gaps = 170/1130 (15%)

Query: 81   KRDDVTLLRQEVQ-------DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
            K   + +L+Q++Q         Q S+ + +    EL +++E+ Q   +   +      ++
Sbjct: 613  KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH---EA 669

Query: 134  SAELQSLEQQLEEAQ---TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190
             A++  LE QL   Q   TE   + Q KD  +++   L   +   K   +EE+     A 
Sbjct: 670  QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL 729

Query: 191  QKVTRLTEELNKEATVI--------QDLKTELLQRPGIE------------DVAVLKKEL 230
            ++  R   EL  E   +        ++L+ E   R G+E            +  VL++EL
Sbjct: 730  EEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL 789

Query: 231  VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQ----LRSELAKGPQEVAVY 286
             +            E E E+L  E    + +Y  S+   +Q     + +L    +E    
Sbjct: 790  AEAMAAQHTA----ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA 845

Query: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE-----ESVSKKNIQATLHQ 341
             QELQ+ K  V  +   ++      L+  +   +L E H       + V +K ++A    
Sbjct: 846  RQELQEAKEKVAGIESHSE------LQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899

Query: 342  KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
             DL    LQ +++A+   + R+   + + GE  +    EL +   +    + E+ + QQ 
Sbjct: 900  DDLST--LQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957

Query: 402  RE---------EKEQHGLQLQSEINQLHSKLLETERQLGEAHG-------RLKEQRQLSS 445
            R+           E+   Q+ +E+ +L + L+E++ Q  E  G       RL ++R  + 
Sbjct: 958  RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017

Query: 446  EKLMDKEQQVADLQLKLSR-LEEQLKEKVTNSTELQHQLDKTKQQHQEQ---QALQQSTT 501
              L  ++   A+L+++L   L EQ  E  T    L H L + + + QE    + L+ +  
Sbjct: 1018 ADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI 1077

Query: 502  AKLREAQNDLEQVLRQIGDKDQK----------------------------IQNLEALLQ 533
             +L E +  ++Q+  Q+  K+++                            +  LE   Q
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137

Query: 534  KSKENISLLEKERE-DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK------LKN 586
            K +E    LE+  E +  ++ +       +  QL+EK   L    + L          + 
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197

Query: 587  QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
            + + H +A++    QV   +         + SLE  V+ LN Q+ E + +  +L   + A
Sbjct: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257

Query: 647  KTEL---------LLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
            ++E          LL AE A  + RA  ++     +  +Q  ++E  K     + +  +L
Sbjct: 1258 ESEKSQKLEERLRLLQAETASNSARAAERS--SALREEVQSLREEAEKQRVASENLRQEL 1315

Query: 698  QDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQR 757
              + E   +L   LK ++EK+   EQ    L+     LE  S +   S+    + L QQ 
Sbjct: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQ-----LEHTSTQALVSELLPAKHLCQQL 1370

Query: 758  QLN-TDLELRATELSKQLEMEKEIVSSTRLDL---QKKSEALESIKQKLTKQE------- 806
            Q      E R  E   +LE  K+     R +L   Q++   L  ++QK+ +QE       
Sbjct: 1371 QAEQAAAEKRHRE---ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427

Query: 807  -------EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
                   E+  +LK+    L++E +   E  N   Q    EL + +   E  + EL+ V+
Sbjct: 1428 AEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR---EKYVQELAAVR 1484

Query: 860  ----DKLSKVSDSLKNSKSEFEKENQK---GKAAILDLEKTCKELKHQLQVQMENT---- 908
                 +L++V    +++  E E    K    K  +L+  +  +E + +L  Q+E      
Sbjct: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544

Query: 909  ---LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
                K+ +EL K L    +AS   + +L ++Q Q  ++Q   ++ + +  +LQ  +++ +
Sbjct: 1545 REQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE 1604

Query: 966  QSSEQKKKQIEALQGELKIAVLQKTELENKLQ--QQLTQAAQELAAEKEKIS-VLQN--- 1019
            Q++E  K Q+E  +        Q  EL+ +L+  +QL +  +EL AE E++   LQ    
Sbjct: 1605 QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL 1664

Query: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
              +++++T + L +     E+++    Q L+ +  K  +A + L S   Q
Sbjct: 1665 KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQ 1713



 Score =  100 bits (250), Expect = 8e-21
 Identities = 153/734 (20%), Positives = 317/734 (43%), Gaps = 87/734 (11%)

Query: 669  LDTAQNALQDKQQELNKITTQL----DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
            L +AQ  L+  + EL K+T  L       +   +D ++   ++++ L    +  L  E  
Sbjct: 81   LVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDG 140

Query: 725  ---TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
                E+LE  ++K    S       E+      Q ++     E+R       LE++K   
Sbjct: 141  LNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKR-----EIRF------LELQKVAS 189

Query: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
            SS+  +    S A        T Q + +++ KQ  +  S   +++ E   NR        
Sbjct: 190  SSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENR-------- 241

Query: 842  QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
             K+  EK+A +  +    D+L+ +++  K + S  E +         +LE+  ++    L
Sbjct: 242  -KLLTEKDAQIAMMQQRIDRLALLNE--KQAASPLEPK---------ELEEL-RDKNESL 288

Query: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
             +++  TLK+ ++LK           Q+  ++N + E+       L++     QQLQ  +
Sbjct: 289  TMRLHETLKQCQDLKTE-------KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDAL 341

Query: 962  NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
            NEL +   +              A  +  E + +L+++L+ A Q+    +EK  +LQ   
Sbjct: 342  NELTEEHSK--------------ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387

Query: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ-EL 1080
             + +E   QLQ +    + E+L     L++++++ +     L +N  Q+  + ++++ E 
Sbjct: 388  SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAA----TLAANNTQLQARVEMLETER 443

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKS--LKEKELVNEKSKL--AEIEEIKCRQ 1136
               +A L  +    E++ Q+    + D+Q   S   + KE + + S+   A +       
Sbjct: 444  GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503

Query: 1137 EKEITKLNEEL--KSHKLESIKEITNLKDAK--QLLIQQKLELQGKADSLKAAVEQEKRN 1192
              E+T LN  +  +  +L  +K+    K A+  Q L QQ+   QG    ++      K+ 
Sbjct: 504  TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563

Query: 1193 QQILKDQVKKEE-------EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
            +Q LK+  +K+E       ++L     E+EA L    +E++  +K+ E  E +   ++  
Sbjct: 564  EQQLKEVAEKQEATRQDHAQQLATAAEEREASL----RERDAALKQLEALEKEKAAKLEI 619

Query: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305
            L + L    +   S+Q  V++ +++  +L  ++  L+A V+  + E+     +  + E +
Sbjct: 620  LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 1306 IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI-KHTQALNRKWAED--NEVQNCMACG 1362
            +   Q K  E +R         ++L    +SL++ K +    ++ A D   E Q C++  
Sbjct: 680  LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739

Query: 1363 KGFSVTVRRHHCRQ 1376
            K  + ++   H R+
Sbjct: 740  KAETRSLVEQHKRE 753


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  206 bits (525), Expect = 1e-52
 Identities = 285/1338 (21%), Positives = 577/1338 (43%), Gaps = 197/1338 (14%)

Query: 90   QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
            Q VQ LQ  + + K    EL+++L +  G  +Q+   D   T+ S +L+S   +LEE Q 
Sbjct: 171  QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRD---TEHSQDLESALIRLEEEQ- 226

Query: 150  ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
                         Q++A LA   A ++ + D+  S  +A  + + ++T +  +       
Sbjct: 227  -------------QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR------- 266

Query: 210  LKTELLQRPGIEDVAVLKKELVQVQTLMDN-----MTLERERES-EKLKDECKKLQSQYA 263
             + EL  R      A  ++E         N     + L R+     +L  E K       
Sbjct: 267  CRKELEHRE-----AAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF----- 316

Query: 264  SSEATISQLRSELAK---GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
             +E  + QL  ELA+     QE  + +    +L  S  E   + Q L +          +
Sbjct: 317  -TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ---------AQ 366

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
            LEE+  ++ + +K++     Q DLD   L +R++    ++ R+  +  EK +  + L E+
Sbjct: 367  LEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK 426

Query: 381  LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE----------TERQL 430
            L  +E+          +LQ+Q   + + G  LQ  +  L   +L           +ER  
Sbjct: 427  LEALESL---------RLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA 477

Query: 431  GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH--------Q 482
              ++G L   R LS ++     ++ +  + +  R         +++  L H        Q
Sbjct: 478  DASNGSL---RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQ 534

Query: 483  LDKTKQQHQEQQALQQSTTAKLREAQND---LEQVLRQIGDKD----QKIQNLEALLQKS 535
            +   + +++  Q L  +   +L +++++   LE+ L+++ DK     Q  ++ +  +Q+ 
Sbjct: 535  VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594

Query: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
            +    LL +E+ +L   +Q  + +   L Q +EK    QE++ +  ++L+ + E   Q  
Sbjct: 595  RSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDG 654

Query: 596  ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
              +  +++     L   + +   L   + E+   L+ +  +   L  +     E L  AE
Sbjct: 655  ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714

Query: 656  AAKT----------AQRADLQNHLD---TAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
            A +           A+ A LQ+ L        +L   + +LN++  QL++  + LQ +Q 
Sbjct: 715  AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774

Query: 703  HCSQLESHLKEYKEKY--LSLEQKT--EELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
               Q  +  +E +E+   L LEQ+   + LEG ++  E    + + + EQ L  L+ +R 
Sbjct: 775  QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE----QAQEALEQQLPTLRHER- 829

Query: 759  LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
              + L+ +  +LS+QL   ++ +   R + Q++ EALE       +   EK+ L ++   
Sbjct: 830  --SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE-------RAAREKEALAKEHAG 880

Query: 819  LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
            L+    +Q        +T   E  ++++EKEAL   L  V+ +L++    L+  + + E 
Sbjct: 881  LA----VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----LEARREQLEA 932

Query: 879  ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
            E Q    A   L      L+ Q+    E         K SL+KE             M +
Sbjct: 933  EGQALLLAKETLTGELAGLRQQIIATQE---------KASLDKEL------------MAQ 971

Query: 939  QLIQAQNTLKQNEKEEQQL-QGNINELKQSSEQKKKQIEALQGELKIAVL-QKTELENKL 996
            +L+QA+   + + +E++   + ++  L++  E   +++EA + +L+  +  ++ EL  +L
Sbjct: 972  KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARL 1031

Query: 997  QQQLTQAAQELAA-EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
            + +  + ++E+AA ++E+   L     + Q+     +S+      +L+ TR  L ++  +
Sbjct: 1032 EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091

Query: 1056 LSLAQEDLISNRNQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
            +   + D  S + Q  +  N L  EL+  +A  E+ +A   Q+++   +  +D+ K++  
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD- 1150

Query: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
                     S L E EE++  Q + +    + L+   LE+ +++   ++ +++  Q+  E
Sbjct: 1151 ---------SCLREAEELRT-QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200

Query: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
            L+          E  +R+ + L+  VKK E E          KL +E KE+++ +   EE
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESE------RISLKLANEDKEQKLALL--EE 1252

Query: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD--------------DLRGEIAV 1280
                +  +   L   L  V++    ++R + EL +Q                +L+G +A+
Sbjct: 1253 ARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312

Query: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQ----------EL 1330
             E   + ++ E   L +R LKGE  +E ++ ++   QRKL       +          E 
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372

Query: 1331 GRENQSLQIKHTQALNRK 1348
             R  +  Q+ H + L  K
Sbjct: 1373 ARGTEKQQLDHARGLELK 1390



 Score =  181 bits (460), Expect = 3e-45
 Identities = 291/1340 (21%), Positives = 572/1340 (42%), Gaps = 137/1340 (10%)

Query: 76   SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKP-DGLVTDSS 134
            S L+   + +   + ++  L A L+EEK   +  +++ E+   + ++E +  + L  +  
Sbjct: 739  SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798

Query: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
               Q LE  L  A+     ++Q       + +QL  ++A +  +        E A ++  
Sbjct: 799  VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ 858

Query: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
            R  E L + A   + L  E     G+    V  +   + +TL +  T  R  E E L+  
Sbjct: 859  RQVEALERAAREKEALAKE---HAGLAVQLVAAER--EGRTLSEEATRLR-LEKEALEGS 912

Query: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
              ++Q Q A  EA   QL +E             EL  L+  +   TQ+  +L + L+ +
Sbjct: 913  LFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIA-TQEKASLDKELMAQ 971

Query: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
                 KL +   E   S +  Q   H++DL  Q+LQ    A+   L     +L  + +  
Sbjct: 972  -----KLVQAEREAQASLRE-QRAAHEEDL--QRLQREKEAAWRELEAERAQLQSQLQRE 1023

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQHGLQL-QSEINQLHSKL--- 423
            Q+  E L+ +E + + L  E   LQQ+R+E       ++Q  L L +SE   L  KL   
Sbjct: 1024 QE--ELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081

Query: 424  --------LETERQLGEAHGRLKEQRQ----LSSEKLMD----KEQQVADLQLKLSRLEE 467
                    LE ERQ  +A  R ++ R     L+SE L D    +E+  A    ++ RL+E
Sbjct: 1082 RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE-LRDLRAQREEAAAAHAQEVRRLQE 1140

Query: 468  QLKEK-------VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
            Q ++        +  + EL+ QL   +      +        KLRE+Q   E   ++ G+
Sbjct: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200

Query: 521  KDQKI----QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
              + +    +  EAL + ++E  S ++K   +  +   A E +   L  L+E    + ++
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260

Query: 577  VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
              +L   L+    S  +A+  L    QE +  ++        L   + EL  +L   +  
Sbjct: 1261 AGELRTGLQEVERSRLEARREL----QELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316

Query: 637  VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN----KITTQLDQ 692
              +   +     + LL  EA+    R +LQ     AQ  LQ+++ E      ++   L++
Sbjct: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQ----VAQRKLQEQEGEFRTRERRLLGSLEE 1372

Query: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
                 + + +H   LE  L+  + +   L  +    EG+ + LEA+   V+  +  A   
Sbjct: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432

Query: 753  LQQQRQ-LNTDLEL-RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
            L   R  L   L L RA          + +  S   D   +            +     Q
Sbjct: 1433 LGGLRSALRRGLGLGRAPS-----PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQ 1487

Query: 811  ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---D 867
                   T      +  E +   ++  + EL+  + E++ L T+ S +  +L+++    D
Sbjct: 1488 PPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERD 1547

Query: 868  SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927
            S  +   + +K   + + A   ++     ++ +L +Q E+  + ++E + +L++      
Sbjct: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA---- 1603

Query: 928  QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ---SSEQKKKQIE----ALQG 980
             L+  L + + +L  +Q  + + +  E +L+G+   LK+   +SE +  ++E    +L+G
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663

Query: 981  ELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1037
            EL+ + L  ++ E     LQ ++    +++A  + K   LQ   E+      +++     
Sbjct: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE----- 1718

Query: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
             ESE  A R  ++ + E L+ +   L S R    ++N  +Q+  TA    E D    +++
Sbjct: 1719 -ESE-GALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTA---CEHDRQVLQER 1769

Query: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH---KLES 1154
            L    +AL + +K+ S   +++   + ++A++E  +   E ++ +L E L+     +  +
Sbjct: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829

Query: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
            +  +  L+D ++LL Q++L   G      A +E EKR       +V++    L+K+ +  
Sbjct: 1830 LNTVQKLQDERRLL-QERL---GSLQRALAQLEAEKR-------EVERSALRLEKDRVAL 1878

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
               L    +EK   ++ HE+   +L+ +   L+  L   + E   +QR++ +LE Q    
Sbjct: 1879 RRTLDKVEREK---LRSHEDT-VRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQ---- 1930

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA----VQEL 1330
               + VLE +    Q E  A  ++ L+ + E+E+L++   + +R L+    A    V+ L
Sbjct: 1931 ---VVVLEQSHSPAQLEVDAQQQQ-LELQQEVERLRSAQAQTERTLEARERAHRQRVRGL 1986

Query: 1331 GRENQSLQIKHTQALNRKWA 1350
              +  +L+ +  Q L R  A
Sbjct: 1987 EEQVSTLKGQLQQELRRSSA 2006



 Score =  165 bits (418), Expect = 3e-40
 Identities = 267/1341 (19%), Positives = 555/1341 (41%), Gaps = 213/1341 (15%)

Query: 126  PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
            P    +DSS  L  +   L + Q +   ++ M+  +E     L T    ++ +  +  S 
Sbjct: 511  PSPACSDSST-LALIHSALHKRQLQ---VQDMRGRYEASQDLLGT----LRKQLSDSESE 562

Query: 186  REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245
            R A E+++ RL ++ +      +D + E+ +     ++   +K       L  ++ + ++
Sbjct: 563  RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKS-----NLAHSLQVAQQ 617

Query: 246  RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305
             ++E+L+ E +KLQ+          +L  E     Q+ A   +EL++    + +L  K  
Sbjct: 618  -QAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676

Query: 306  TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ---SRLSASETSLHR 362
             L + L++  +  ++   + +     K  +   L + +    +L+   ++L A E SL  
Sbjct: 677  VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
               +LS   E+  + K +L+ +  + +  K+  +  Q+Q E++     + Q  + +L  +
Sbjct: 737  SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
              E  RQ  E   R+ EQ Q   E L   EQQ+  L+ + S+L+EQL        +L  Q
Sbjct: 797  -QEVARQGLEGSLRVAEQAQ---EAL---EQQLPTLRHERSQLQEQL-------AQLSRQ 842

Query: 483  LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
            L   +Q+ ++ +          REAQ  +E + R   +K+                   L
Sbjct: 843  LSGREQELEQAR----------REAQRQVEALERAAREKE------------------AL 874

Query: 543  EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
             KE   L  ++ A E E            TL E+ T+L           K+A E    +V
Sbjct: 875  AKEHAGLAVQLVAAERE----------GRTLSEEATRL--------RLEKEALEGSLFEV 916

Query: 603  QEQKAHLRAAQDR--------VLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTELL 651
            Q Q A L A +++        +L+ ET   E   L  Q+  ++EK S LD ++ A+ +L+
Sbjct: 917  QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS-LDKELMAQ-KLV 974

Query: 652  LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH-CSQLESH 710
             +   A+ + R     H +  Q   ++K+    ++  +  Q+ ++LQ +QE   ++LE+ 
Sbjct: 975  QAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE 1034

Query: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770
             +E  E+  +L+Q+ +E     +  +  +L +K S++ AL     ++ + T    R +  
Sbjct: 1035 KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL----SEKLMGT----RHSLA 1086

Query: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
            +  LEME++     + D Q + E   S    LT +        +D     +E    H + 
Sbjct: 1087 TISLEMERQ-----KRDAQSRQEQDRSTVNALTSE-------LRDLRAQREEAAAAHAQE 1134

Query: 831  NNRIQTTVTELQKVK----MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
              R+Q    +L K +     E E L T+L  ++D    +   L  ++ +  +E+Q+G+  
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL-RESQEGREV 1193

Query: 887  ILDLEKTCKELKHQL---QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
                 +   EL+  L     + E   +  +EL+ +++K +     LKL     +++L   
Sbjct: 1194 ---QRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALL 1250

Query: 944  QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
            +       KE  +L+  + E+++S  + +++++ L+ ++K+   + T L  +L +   + 
Sbjct: 1251 EEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRL 1310

Query: 1004 AQELAAEKE-----------------KISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
            A    AEKE                  + V++   + +Q   ++ + +F  RE  LL + 
Sbjct: 1311 ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL 1370

Query: 1047 QDLKSVEE-----------KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
            ++ +  E+           KL  A+ +      ++       Q L+   A +E      E
Sbjct: 1371 EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430

Query: 1096 QQLQERCKALQ---DIQKEKSLKEKELVNEKSKLAEIE----------EIKCRQEKE--- 1139
             QL     AL+    + +  S   + +    ++ A  E           ++C    +   
Sbjct: 1431 AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490

Query: 1140 --------------------ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
                                + +  +EL+S +    +E   L+     L +Q  E++ + 
Sbjct: 1491 PGPATSPASPDLDPEAVRGALREFLQELRSAQ----RERDELRTQTSALNRQLAEMEAER 1546

Query: 1180 DSL--------KAAVEQEKRNQQI------------LKDQVKKEEEELKKEFIEKEAKLH 1219
            DS         KA  E E+  + +            L+++  +  E  ++  +++ A L 
Sbjct: 1547 DSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLE 1606

Query: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
              ++  E  ++  +E  +K+    T L  +   +K+   +S+ R  +LE Q   L GE+ 
Sbjct: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQ 1666

Query: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
                 + + + + +AL +R    + ++   + K   LQ  ++    A+ ++     +L+ 
Sbjct: 1667 RSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD 1726

Query: 1340 K---HTQALNRKWAEDNEVQN 1357
            K    T+AL +  A  N  ++
Sbjct: 1727 KVRGLTEALAQSSASLNSTRD 1747



 Score =  161 bits (408), Expect = 4e-39
 Identities = 289/1461 (19%), Positives = 574/1461 (39%), Gaps = 235/1461 (16%)

Query: 93   QDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT---DSSAELQSLEQQLEEAQT 149
            QDL  +L+++   SE  ++ LE+   LQ+   K DG +    D+  E+Q L    E    
Sbjct: 546  QDLLGTLRKQLSDSESERRALEEQ--LQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 603

Query: 150  ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
            E  N+     + +Q+A +L  E   +++  +E R  R+  E++     ++  +    ++ 
Sbjct: 604  EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663

Query: 210  LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER---ESEKLKDECKKLQSQYASSE 266
               +L Q  G    +VL KELV+V+  +   TL+R+    E  ++ +   K ++     E
Sbjct: 664  SHRQLEQLEGKR--SVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721

Query: 267  ATISQLRSELAKGPQEVAVY-------VQELQKLKSSVNELTQKNQTLTENLLKKEQDYT 319
             ++++LR+E A     ++          Q+   L   V +L ++   L     + EQ+ T
Sbjct: 722  LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781

Query: 320  -------KLEEKHNEESVSKKNIQATLH-----QKDLDCQ----------------QLQS 351
                   +LEE   E+ V+++ ++ +L      Q+ L+ Q                QL  
Sbjct: 782  VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841

Query: 352  RLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
            +LS  E  L +   E   + EA ++   E   +  ++  L  +    +++     +   +
Sbjct: 842  QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901

Query: 412  LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE----------QQVADLQLK 461
            L+ E   L   L E +RQL +   R ++        L+ KE          QQ+   Q K
Sbjct: 902  LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK 961

Query: 462  LSRLEEQLKEKVTNST-ELQHQLDKTKQQHQEQ-QALQQSTTAKLREAQNDLEQVLRQI- 518
             S  +E + +K+  +  E Q  L + +  H+E  Q LQ+   A  RE + +  Q+  Q+ 
Sbjct: 962  ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021

Query: 519  -----------GDKDQKIQNLEALLQKSKENI-----------SLLEKEREDLYAKIQAG 556
                        +K++  + + AL Q+  E +           SL E E+  L  K+   
Sbjct: 1022 REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081

Query: 557  EGETAVLNQLQEKN----------------------------------------HTLQEQ 576
                A ++   E+                                           LQEQ
Sbjct: 1082 RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQ 1141

Query: 577  VTQL----------TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD------------ 614
               L           E+L+ Q    + A++ L  ++ E +  LR +Q+            
Sbjct: 1142 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGEL 1201

Query: 615  -RVL--------SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA---QR 662
             R L        +L  S  EL S + +++ +   L +  + K + L   E A+TA   + 
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL-------KEYK 715
             +L+  L   + +  + ++EL ++  Q+  + ++        ++L+  L       KE +
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321

Query: 716  EKYLSLEQKT-----------EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
             + L L Q+            +EL+   +KL+    E +  + + L  L++ R      E
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR----GTE 1377

Query: 765  LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
             +  + ++ LE++ E           ++EA E +  +L+  E   Q L+ +   +  + +
Sbjct: 1378 KQQLDHARGLELKLEAA---------RAEAAE-LGLRLSAAEGRAQGLEAELARVEVQRR 1427

Query: 825  IQHEELNNRIQTTVTELQKVKMEKEA-LMTELSTVKDKLSKVSDSLKNSKSEFE-----K 878
                +L          L   +    A      S  +D  ++ S    NS S  E     +
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQ 1487

Query: 879  ENQKGKAAI-----LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
                G A       LD E     L+  LQ ++ +  +E+ EL+           +++ E 
Sbjct: 1488 PPSPGPATSPASPDLDPEAVRGALREFLQ-ELRSAQRERDELRTQTSALNRQLAEMEAER 1546

Query: 934  NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
            +S   +  Q Q  + ++E+  + + G ++ ++     +++ +   + E +  + Q   LE
Sbjct: 1547 DSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLE 1606

Query: 994  NKLQQQLTQAAQELAAEKEKISVLQNNYEK--------------SQETFKQLQSDFYGRE 1039
              LQ        EL A +EKIS ++ N  K              S+    +L+      E
Sbjct: 1607 RSLQ----ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662

Query: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQI-------GNQNKLIQELKTAKATLEQDSA 1092
             EL  +R  L   E +    Q+ + S + Q+       G     ++ L  A A +E+   
Sbjct: 1663 GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEG 1722

Query: 1093 KKEQQLQERCKAL-QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
                +++   +AL Q      S ++K L  +K+  A   + +  QE+ +    + L   +
Sbjct: 1723 ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER-LDAARQALSEAR 1781

Query: 1152 LESI---KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK 1208
             +S    +++  L+     L  Q++E +G+   L+  + Q +  +    + V+K ++E +
Sbjct: 1782 KQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDE-R 1840

Query: 1209 KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268
            +   E+   L   + + E   ++ E +  +L     AL   L  V++E   S      L 
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS 1900

Query: 1269 KQTDDL-----RGEIAVLEATVQNNQDERRALLERCLKGEGEIE-KLQTKVLELQRKLDN 1322
             +   L       E+ + EA  Q  Q E + ++        ++E   Q + LELQ++++ 
Sbjct: 1901 AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVER 1960

Query: 1323 TTAAVQELGRENQSLQIKHTQ 1343
              +A  +  R  ++ +  H Q
Sbjct: 1961 LRSAQAQTERTLEARERAHRQ 1981



 Score =  149 bits (376), Expect = 2e-35
 Identities = 247/1197 (20%), Positives = 482/1197 (40%), Gaps = 211/1197 (17%)

Query: 295  SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354
            +S+  L ++NQ L + L + E    +   + +E ++    +   L Q          RL 
Sbjct: 74   ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA--------LRLE 125

Query: 355  ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
              E         + +  E  ++L+EE +    K Q     +++ QQ++ +  Q   +LQ 
Sbjct: 126  PGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQ----AYQEGQQRQAQLVQ---RLQG 178

Query: 415  EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
            +I Q   +  E E+QL E  G L++QR      L D E    DL+  L RLEE+ +    
Sbjct: 179  KILQYKKRCSELEQQLLERSGELEQQR------LRDTEHS-QDLESALIRLEEEQQ---- 227

Query: 475  NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD----QKIQNLEA 530
             S  L       ++Q  +  +  Q+ +  +R+  ND  +  +++  ++    ++ ++  A
Sbjct: 228  RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNA 287

Query: 531  LLQKSKENISLLEKE---------------REDLY-----------AKIQAGEGETAVLN 564
                    + LL ++                 DL            A  +AG G +  L 
Sbjct: 288  YFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR 347

Query: 565  QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
              + +     E+   L  +L+ Q       +++L  Q  +          RV  L  +V 
Sbjct: 348  LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407

Query: 625  ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA-KTAQRADLQNHL-DTAQNALQDKQQ- 681
             L  Q  E  +    L  +++A   L L  +AA +T     LQ  L D AQ  L D +  
Sbjct: 408  RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESG 467

Query: 682  ---------------ELNKITTQ-------------------------LDQVTAKLQDKQ 701
                            L  ++ Q                          D  T  L    
Sbjct: 468  VQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSA 527

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ---------- 751
             H  QL+  +++ + +Y    + +++L G ++K  +DS   + + E+ LQ          
Sbjct: 528  LHKRQLQ--VQDMRGRY----EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581

Query: 752  --------DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
                    ++Q+ R  N  L    + L+  L++ ++     R + +K   A E ++++  
Sbjct: 582  QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641

Query: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
            + EEE++   QD   + +E +  H            +L++++ ++  L  EL  V++ LS
Sbjct: 642  RLEEEQEDAVQDGARVRRELERSHR-----------QLEQLEGKRSVLAKELVEVREALS 690

Query: 864  KVS---DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
            + +   D L+  K+E  +   K +A  ++LE +  +L+ + +  ++++L +   L +SL 
Sbjct: 691  RATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAE-EASLQDSLSKLSALNESLA 749

Query: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
            ++       KL+LN +  QL          E+E+  LQG   + +Q +   +++ E L+ 
Sbjct: 750  QD-------KLDLNRLVAQL----------EEEKSALQGRQRQAEQEATVAREEQERLE- 791

Query: 981  ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
            EL+   L++      L+  L  A Q   A ++++  L++   + QE   QL     GRE 
Sbjct: 792  ELR---LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ 848

Query: 1041 ELLATRQDL--------KSVEEKLSLAQE------DLISNRNQIGNQNKLIQELKTAKAT 1086
            EL   R++         ++  EK +LA+E       L++   +    ++    L+  K  
Sbjct: 849  ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEA 908

Query: 1087 LEQDSAKKEQQLQERCKALQDIQKEKS---LKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
            LE    + ++QL +     + ++ E     L ++ L  E + L   ++I   QEK    L
Sbjct: 909  LEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR--QQIIATQEK--ASL 964

Query: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
            ++EL + KL   +        +Q    ++ +LQ      +AA  + +  +  L+ Q+++E
Sbjct: 965  DKELMAQKLVQAEREAQASLREQRAAHEE-DLQRLQREKEAAWRELEAERAQLQSQLQRE 1023

Query: 1204 EEEL-------KKEFIEKEAKLHSE--------IKEKEVGMKKHEENEAKLTMQITALNE 1248
            +EEL       K+E  E+ A L  E          EK+  +   E  +  L+ ++     
Sbjct: 1024 QEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRH 1083

Query: 1249 NLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEK 1308
            +L T+  E +  +R     ++Q      + + + A     +D R    E       E+ +
Sbjct: 1084 SLATISLEMERQKRDAQSRQEQ------DRSTVNALTSELRDLRAQREEAAAAHAQEVRR 1137

Query: 1309 LQTKVLELQRKLDNTTAAVQEL---------GRENQSLQIKHTQALNRKWAEDNEVQ 1356
            LQ +  +L ++ D+     +EL          R+    ++   Q   R+  E  EVQ
Sbjct: 1138 LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194



 Score =  100 bits (250), Expect = 8e-21
 Identities = 166/799 (20%), Positives = 329/799 (41%), Gaps = 73/799 (9%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
            E  LAL  +  T + +E  +L+  L+E +    E ++EL   Q L++Q    D   T   
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARREL---QELRRQMKMLDSENTRLG 1300

Query: 135  AELQSLEQQL-------EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
             EL  L+ +L       +E++ E   ++Q     E     +  E+   + K  E+     
Sbjct: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360

Query: 188  AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE-RER 246
              E+++    EE           K +L    G+E    LK E  + +     + L   E 
Sbjct: 1361 TRERRLLGSLEEARGTE------KQQLDHARGLE----LKLEAARAEAAELGLRLSAAEG 1410

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
             ++ L+ E  +++ Q  ++EA +  LRS L +G           + +  S          
Sbjct: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS-----PARDA 1465

Query: 307  LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
              E   +     + LE     +  S     +     DLD + ++  L      L     E
Sbjct: 1466 PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPA-SPDLDPEAVRGALREFLQELRSAQRE 1524

Query: 367  LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
              E    T  L  +L+E+E +     +  +QLQ+   E E+    +   ++ + ++L   
Sbjct: 1525 RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQ 1584

Query: 427  ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK---EKVTNSTELQHQL 483
            E    E+  R + +R+ + +       QVA L+  L   E +L+   EK++     + +L
Sbjct: 1585 E----ESVRRSERERRATLD-------QVATLERSLQATESELRASQEKISKMKANETKL 1633

Query: 484  DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR--QIGDKDQKIQNLEALLQKSKENISL 541
            +  K++ +E     +S T KL   +  LE  L+  ++G  D+     EA  Q  ++ +  
Sbjct: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR-----EAQAQALQDRVDS 1688

Query: 542  LEKEREDLYAKIQAG------EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES-HKQA 594
            L+++  D  ++++AG      E     L +++E    L+++V  LTE L   S S +   
Sbjct: 1689 LQRQVAD--SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746

Query: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
             +NLH     QKA      DR + L+  ++     L+E++++ S L  Q++     +   
Sbjct: 1747 DKNLH----LQKALTACEHDRQV-LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ---VTAKLQDKQEHCSQLESHL 711
            E  +      LQ   +  +   + +   LN +    D+   +  +L   Q   +QLE+  
Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEK 1861

Query: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
            +E +   L LE+    L   + K+E + L       +   +  +  +  T  EL   E  
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921

Query: 772  KQL-EMEKEIV------SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
            +Q+ ++E ++V      S  +L++  + + LE ++Q++ +    +   ++  E   +  +
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHR 1980

Query: 825  IQHEELNNRIQTTVTELQK 843
             +   L  ++ T   +LQ+
Sbjct: 1981 QRVRGLEEQVSTLKGQLQQ 1999



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 163/812 (20%), Positives = 340/812 (41%), Gaps = 92/812 (11%)

Query: 605  QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL-----LSAEAAKT 659
            + A L + Q+    L+  ++ +   L +S+ +  +L I+  A +E L     L     +T
Sbjct: 72   EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET 131

Query: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
             +   L       +  LQ++Q    +   +L       Q + +   +L+  + +YK++  
Sbjct: 132  QEPRGLVRQSVELRRQLQEEQASYRR---KLQAYQEGQQRQAQLVQRLQGKILQYKKRCS 188

Query: 720  SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
             LEQ+  E  G++++      E     E AL  L++++Q +  L      L +QL+    
Sbjct: 189  ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGS 248

Query: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
               +   D++K +      +++L   E  +   +++ E+ +     +H  L    +  V 
Sbjct: 249  ANQALSEDIRKVTNDWTRCRKEL---EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS----KSEFEKENQKGKAAILDLEKTCK 895
              + V   K     +L  +  +L++ S +++ +     +       + +AA+        
Sbjct: 306  FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL-------- 357

Query: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
            E +  LQ Q+E  L+++   +K L +++  S   K +L++   +L  A   L++   E+ 
Sbjct: 358  EKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKD 417

Query: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE--- 1012
            Q+  ++ E  ++ E  + Q +A           +TE    LQQ L   AQ + ++ E   
Sbjct: 418  QVNKDLTEKLEALESLRLQEQA---------ALETEDGEGLQQTLRDLAQAVLSDSESGV 468

Query: 1013 KISVLQNNYEKSQETFKQL-----------QSDFYGR-----------ESELLATRQDLK 1050
            ++S  +   + S  + + L            S   GR           +S  LA    + 
Sbjct: 469  QLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL---IH 525

Query: 1051 SVEEKLSLAQEDL----ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
            S   K  L  +D+     ++++ +G   K + + ++ +  LE+   +   +     +A +
Sbjct: 526  SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585

Query: 1107 DIQKE----KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
            D Q+E    +S  E  L  EKS LA   ++  +Q +E+ +  E+L++ + E  ++   L+
Sbjct: 586  DAQREVQRLRSANEL-LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL-------------KK 1209
            + ++  +Q    ++ + +     +EQ +  + +L  ++ +  E L             K 
Sbjct: 645  EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKA 704

Query: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKL---TMQITALNENLGTVKKEWQSSQRRVSE 1266
            E  E   K  +   E E+ M K    EA L     +++ALNE+L   K +     R V++
Sbjct: 705  EVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD---LNRLVAQ 761

Query: 1267 LEKQTDDLRG--EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTT 1324
            LE++   L+G    A  EATV   + ER  L E  L+ E   + L+  +   ++  +   
Sbjct: 762  LEEEKSALQGRQRQAEQEATVAREEQER--LEELRLEQEVARQGLEGSLRVAEQAQEALE 819

Query: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
              +  L  E   LQ +  Q   +    + E++
Sbjct: 820  QQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score =  206 bits (525), Expect = 1e-52
 Identities = 288/1409 (20%), Positives = 601/1409 (42%), Gaps = 173/1409 (12%)

Query: 49   SLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEE 108
            S   ++EL +  E +H    ++G   E+N A++ D +  + Q    ++  + E+      
Sbjct: 296  SEAKSNELTRAVEELHKLLKEAG---EANKAIQ-DHLLEVEQSKDQMEKEMLEK---IGR 348

Query: 109  LKKELEKYQGLQQQEAKPDGLVTDSS-AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
            L+KELE    L     +   ++++   A +      + +       + ++ + + +   Q
Sbjct: 349  LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408

Query: 168  LATEIADIK--SKYDEE---------------RSLREAAEQKVTRLTEELNKEATVIQDL 210
            L  E  + K  +KY +E               R   E A++ V  L+ +L +    IQ L
Sbjct: 409  LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468

Query: 211  KTE---------LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
            + +         +L+R        +K    Q++ L+  M LE  R +  ++DE       
Sbjct: 469  QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLL--MELEEARGNHVIRDEEVSSADI 526

Query: 262  YASSEATISQLRS-----ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
             +SSE     L S     EL +  Q + V ++EL + +    + T  ++ +TE  LK E 
Sbjct: 527  SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK-ITELQLKLES 585

Query: 317  DYTKLEEKHNEESVSKKNIQATLHQKD----LDCQQLQSRLSASETSLHRIHVELSEKGE 372
              T+LE+         + + + + Q+D    L  Q     +    +SL  + +  + K  
Sbjct: 586  ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645

Query: 373  ATQKLKEELSEV----ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
            +T +     + V     T+    KA  KQLQ+  E  ++   + +   N+   KL E   
Sbjct: 646  STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705

Query: 429  QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
             L   + ++  Q   +S++    +  V   + +++ L E+  +K+T +T+ Q Q+  T  
Sbjct: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMT 764

Query: 489  QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
            Q        +    KL  A+   E + ++     + ++  E  L + +E++   ++ +  
Sbjct: 765  QDL------RGANEKLAVAEVRAENLKKE----KEMLKLSEVRLSQQRESLLAEQRGQNL 814

Query: 549  LYAKIQAGEG-----ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
            L   +Q  +G     ET    +L  +   L+ +++ L +KL+N+ E       NL  Q+ 
Sbjct: 815  LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874

Query: 604  EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS-AEAAKTAQR 662
            + K  L    +  L+ +  +     ++   K+ +S +++Q+ +++       + +     
Sbjct: 875  DTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDV 934

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-----------LESHL 711
             DL + L   +  + D ++ L   T+ ++Q  A +   +E  ++           +E  L
Sbjct: 935  DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL 994

Query: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-----QRQLNTDLELR 766
            KE  E    LE+K  E+E + ++L+ D      S EQ L +L++     Q ++   L+  
Sbjct: 995  KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054

Query: 767  ATELSKQLEMEKEIVSSTRLDLQKKS-------------EALESIKQKLTKQEEEKQILK 813
            +T LS + +  ++     ++ ++ ++             EAL++ K++++K    +Q L+
Sbjct: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114

Query: 814  ---QDFETLSQETKIQHEE----LNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKV 865
               Q  E+   E K   EE    L + +   V   + ++ +   L  ++  + DK+ + V
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174

Query: 866  SDSLKNSKSEFEKENQKGKAAILDL------EKTCKELKHQL--------QVQMENTLKE 911
             + ++   +    E  K +  IL++      EK   E + ++        + ++E   +E
Sbjct: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234

Query: 912  QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
             +EL+ SL  E+E   Q+  +  +  E+L++   T+    +  + L+     L+Q  +Q 
Sbjct: 1235 LQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293

Query: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ------ 1025
            + ++  L  EL I  LQ+   E   +  + QA ++L  E  K    +N +  SQ      
Sbjct: 1294 QAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT 1351

Query: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
            E +++L S+       +    +++  ++ +++ +   L +N+N I +  + + +++T K 
Sbjct: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411

Query: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
            T+++D   K   +QE+ K +  ++K         +  + K  + EE+K +Q+K +    +
Sbjct: 1412 TIQKDLDAKIIDIQEKVKTITQVKK---------IGRRYK-TQYEELKAQQDKVMETSAQ 1461

Query: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
                H+ + +  +  +++ K+ L Q +     K+ SL++ VE  ++           E+E
Sbjct: 1462 SSGDHQEQHVS-VQEMQELKETLNQAET----KSKSLESQVENLQKTLS--------EKE 1508

Query: 1206 ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE--------------NLG 1251
               +   E+  +L SE+      ++     E +L  QIT   E              +L 
Sbjct: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568

Query: 1252 TVK----KEWQSSQRRVSELEKQTDDLRGEIAVL----EATVQNNQDERRALLERCLKGE 1303
             VK    KE +  ++R   L++Q D+L   I  L    E  +   + E R   ER L+  
Sbjct: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQR 1628

Query: 1304 GEIEKLQTKVLELQRKLD-NTTAAVQELG 1331
             E ++   KV E QR++   TT A  E G
Sbjct: 1629 DEPQEPSNKVPEQQRQITLKTTPASGERG 1657



 Score =  201 bits (512), Expect = 3e-51
 Identities = 286/1324 (21%), Positives = 577/1324 (43%), Gaps = 160/1324 (12%)

Query: 86   TLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
            T L+ +  +L A  +E+     ELK  LE K + + + E + +GL T +    + L++ +
Sbjct: 199  TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN----EHLQKHV 254

Query: 145  EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK-- 202
            E+  T+    K+ +   E+K          + + Y       EA   ++TR  EEL+K  
Sbjct: 255  EDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL 314

Query: 203  ----EAT-VIQDLKTEL------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
                EA   IQD   E+      +++  +E +  L+KEL     L+       +R+   L
Sbjct: 315  KEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS----ATKRKGAIL 370

Query: 252  KDECKKLQSQYASSEATI-------SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
             +E     S  A++ A I       ++L +   +   ++ +   E +++   ++E+ ++ 
Sbjct: 371  SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430

Query: 305  QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
            +     L ++ ++Y + ++     SV  +     + +   D  +   + S  E    R+ 
Sbjct: 431  EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490

Query: 365  VELSEKGEATQKLKEELSEVETKY--QHLKAEFKQLQQQREEKEQHGLQLQS--EINQLH 420
            +++ +  +  + L  EL E    +  +  +     +    E   QH +  ++  E+ Q +
Sbjct: 491  IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550

Query: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
             +LL   R+LGE   R +E+++ +S K       + +LQLKL     +L E++  S + Q
Sbjct: 551  QRLLVALRELGET--REREEQETTSSK-------ITELQLKLESALTEL-EQLRKSRQHQ 600

Query: 481  HQL--DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK-------------I 525
             QL     +Q+   +  L Q+T   +    + L+ V      K                I
Sbjct: 601  MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660

Query: 526  QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL---TE 582
            ++ EA+  ++K  +  L++  E+   K +  E E     QL++    LQEQVT L     
Sbjct: 661  ESTEAI--EAKAALKQLQEIFENY--KKEKAENEKIQNEQLEK----LQEQVTDLRSQNT 712

Query: 583  KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL-------ETSVNELNSQLNESKE 635
            K+  Q +   +  E L D V+  +  + +  +R   L       E  +N +   L  + E
Sbjct: 713  KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772

Query: 636  KVSQLDIQ---IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
            K++  +++   +K + E+L  +E   + QR            +L  +Q+  N + T L  
Sbjct: 773  KLAVAEVRAENLKKEKEMLKLSEVRLSQQR-----------ESLLAEQRGQNLLLTNLQT 821

Query: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
            +   L+  +    Q                     L  QI+KLE    E+   K++   +
Sbjct: 822  IQGILERSETETKQ--------------------RLSSQIEKLEH---EISHLKKKLENE 858

Query: 753  LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
            ++Q+  L  +L+++  +  +QL+ E  +  +T+  L+   + + ++KQ L+    E Q+ 
Sbjct: 859  VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916

Query: 813  KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
             Q  +   +      E++++ +       ++V   KE L T  S V+   + V+ SL+ S
Sbjct: 917  SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEES 975

Query: 873  KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
                 KE Q  +    ++E   KE   + Q Q+E  L E ++ K+ L+ +K  +      
Sbjct: 976  ---LNKEKQVTEEVRKNIEVRLKE-SAEFQTQLEKKLMEVEKEKQELQDDKRRA------ 1025

Query: 933  LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
            + SM++QL + + TL   + E Q+     +    + +Q ++     Q + KIAV    E 
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD---CQEQAKIAV----EA 1078

Query: 993  ENKLQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049
            +NK +++L   A   + L A KE++S + +  +  +ET ++ +S     ++      + L
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERML 1138

Query: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
            K    K     EDL      + +Q + + + K   +  E         L E  K+ + I 
Sbjct: 1139 KDEVSKCVCRCEDLEKQNRLLHDQIEKLSD-KVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197

Query: 1110 KEKSL--KEKELVNEKSKLAEIEEIKCRQ-----EKEITKLNEELKSHKLESIKEITNLK 1162
            +      +EKE+   + ++A++E ++ RQ     E+E+ +L + L + + E ++      
Sbjct: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER-EKVQVTAKTM 1256

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD---QVKKEE------EELKKEFIE 1213
               + L+++   +    ++ K   E+++R +Q L+    +V+K E      +E   E  E
Sbjct: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE 1316

Query: 1214 KEAKLHSEIKEKEVGMKKHE-ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
            K   L +E K  E  +K+ +  N+  ++ Q     E    +  E +   +R+ +L ++  
Sbjct: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376

Query: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ----TKVLELQRKLDNTTAAVQ 1328
             L+ EIA   A++ NNQ+  ++L E   K   E E +Q     K++++Q K+  T   V+
Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV-KTITQVK 1435

Query: 1329 ELGR 1332
            ++GR
Sbjct: 1436 KIGR 1439



 Score =  186 bits (472), Expect = 1e-46
 Identities = 267/1363 (19%), Positives = 590/1363 (43%), Gaps = 142/1363 (10%)

Query: 83   DDVTLLRQEVQDLQASLKEEKWYSE---ELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
            +D+    +E ++ QAS+ EEK+++E    +K            EAK + L T +  EL  
Sbjct: 255  EDLLTKLKEAKEQQASM-EEKFHNELNAHIKLSNLYKSAADDSEAKSNEL-TRAVEELHK 312

Query: 140  LEQQLEEA----QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
            L ++  EA    Q     ++Q KD  E+   ++  +I  ++ + +    L  A ++K   
Sbjct: 313  LLKEAGEANKAIQDHLLEVEQSKDQMEK---EMLEKIGRLEKELENANDLLSATKRKGAI 369

Query: 196  LTEE----LNKEATVIQDLK------TELLQR-PGIEDVAVLKK-ELVQVQTLMDNMTLE 243
            L+EE    ++  A  +  +       TEL       +D  +L+K E  ++   +D +  E
Sbjct: 370  LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429

Query: 244  RERESEKLK---DECKKLQSQYASSEATISQLRSELA-------KGPQEVAVYVQELQKL 293
             E ++  LK   +E ++ Q   AS    + Q   E+        K  ++ +V  ++ +++
Sbjct: 430  VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489

Query: 294  KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL-DCQQLQSR 352
            +  V +L+Q+ + L   L +   ++   +E+ +   +S  +   + H     + ++LQ +
Sbjct: 490  EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549

Query: 353  LSASETSLHRIHVELSEKGEATQKLKEE-----LSEVETKYQHLKAEFKQLQQQREEKEQ 407
                     R+ V L E GE  ++ ++E     ++E++ K +    E +QL++ R+ + Q
Sbjct: 550  NQ-------RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
                +  + +     L +T       H    +   L+S        Q       +  +E 
Sbjct: 603  LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662

Query: 468  -QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE----QVLRQIGDKD 522
             +  E      +LQ   +  K++  E + +Q     KL+E   DL     ++  Q+    
Sbjct: 663  TEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS 722

Query: 523  QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLT 581
            ++ + L+  ++  +  I+ L +  + L A  Q  E     + Q L+  N  L     +  
Sbjct: 723  KRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR-A 781

Query: 582  EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
            E LK + E  K ++  L  Q +   A  R     + +L+T    L     E+K+++S   
Sbjct: 782  ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841

Query: 642  IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
             +++ +   L      +  QR  L  +LD     L D +++L+  T         L++ Q
Sbjct: 842  EKLEHEISHLKKKLENEVEQRHTLTRNLDVQ---LLDTKRQLDTETNLHLNTKELLKNAQ 898

Query: 702  EHCSQLESHLKEYKEKYLSL------------EQKTEELEGQIKKLEADSLEVKASKEQA 749
            +  + L+ HL   + +  S             ++  ++L  Q+++ E    ++K   + +
Sbjct: 899  KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958

Query: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
              +++Q + + T LE     L+K+ ++ +E+  +  + L++ +E    +++KL + E+EK
Sbjct: 959  TSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015

Query: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQKV------------------------- 844
            Q L+ D     +  + Q  EL   + +   E+Q+                          
Sbjct: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075

Query: 845  -----KMEKEALM-----TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894
                 K E+E ++       L   K+++SK++    + +   E+  QK ++ +L+ + + 
Sbjct: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMA----SVRQHLEETTQKAESQLLECKASW 1131

Query: 895  KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEK 952
            +E +  L+ ++   +   ++L+K      +   +L  ++ +  ++ +Q     +L +  K
Sbjct: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191

Query: 953  EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
             ++Q+   +  +++  E  + + E  Q E  +   Q+ EL   L+++L +    L AE+E
Sbjct: 1192 SQEQILEILRFIRREKEIAETRFEVAQVE-SLRYRQRVEL---LERELQELQDSLNAERE 1247

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRES------ELLATRQDLKSVEEKLSLAQEDLISN 1066
            K+ V      + +E  K+ ++     E+      E     QDL+ ++ K+   + D++  
Sbjct: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307

Query: 1067 RNQIGNQNKLIQELKTAKATLEQDSAK---KEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
            +      ++    L+  K  LE+D  +   + Q L  + K     +  K L EKE+    
Sbjct: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEV--HT 1365

Query: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHK--LESIKEITNLKDAKQLLIQQKLELQGKADS 1181
             ++ ++ E   R + EI + N  L +++  ++S+KE  N    ++  IQ+  +L  K   
Sbjct: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK--DLDAKIID 1423

Query: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKE---FIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
            ++  V+   + ++I + + K + EELK +    +E  A+   + +E+ V +++ +E +  
Sbjct: 1424 IQEKVKTITQVKKIGR-RYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482

Query: 1239 LTMQIT---ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
            L    T   +L   +  ++K     +     L++QT  L+ E++ L   +Q+   +   L
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542

Query: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
             ++  + E   EK +  ++  + K+ +      +L +EN+ L+
Sbjct: 1543 RQQITEKE---EKTRKAIVAAKSKIAHLAGVKDQLTKENEELK 1582



 Score =  162 bits (409), Expect = 3e-39
 Identities = 274/1282 (21%), Positives = 525/1282 (40%), Gaps = 201/1282 (15%)

Query: 226  LKKELVQVQTLMDNMTLERERESEKLKDECKKL----QSQYASSEATISQLRSELAKGPQ 281
            L K    VQ  ++    +++ E + LK   +K     + QY   E  +S  +  L    +
Sbjct: 14   LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR 73

Query: 282  EVAVYVQELQKLKSSVNELTQKNQTLT---ENLLKKEQDYTKLEEKHNEESV----SKKN 334
            E      EL+KL + +  LT+KN+ L    +  +  +  +T+ +E+   E      + + 
Sbjct: 74   ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER 133

Query: 335  IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKA 393
            +   L     D ++L  +L  S T+          KGE   KL E + S+V  KY+    
Sbjct: 134  LSQELEYLTEDVKRLNEKLKESNTT----------KGELQLKLDELQASDVSVKYRE--- 180

Query: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
              K+L+Q++E        L +E+     +LL   R+ G     LK         L +K++
Sbjct: 181  --KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN-------LENKKE 231

Query: 454  QVADLQLKLSRLEEQLKEKVTNSTELQHQ----LDKTKQQHQEQQALQ------------ 497
            +V       SRLEEQ+    T++  LQ      L K K+  ++Q +++            
Sbjct: 232  EV-------SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284

Query: 498  ------------QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK--------E 537
                        ++ + +L  A  +L ++L++ G+ ++ IQ+    +++SK        E
Sbjct: 285  LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344

Query: 538  NISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
             I  LEKE E+    + A + + A+L++              ++ +   KL     ++ +
Sbjct: 345  KIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVE 404

Query: 594  AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE---SKEKVSQLDIQI-KAKTE 649
             Q+ L  +  E K   +   + V  +E     L  Q  E   +++ V+ L +++ +A  E
Sbjct: 405  TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464

Query: 650  LLLSAEAAKTAQRADLQNHLDTAQNALQ--DKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
            +    E    A +       D  +  +Q  D  Q++  +  +L++       + E  S  
Sbjct: 465  IQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSA 524

Query: 708  E-SHLKEYKEKYLSLEQKTEELEGQIKKL-----------EADSLEVKASK--------E 747
            + S   E   ++L   +  EEL+ Q ++L           E +  E  +SK        E
Sbjct: 525  DISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLE 584

Query: 748  QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS-STRLDLQKKSEALESI------KQ 800
             AL +L+Q R+           + +Q +M + ++S +T + +   + +L+ +      K+
Sbjct: 585  SALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKR 644

Query: 801  KLTKQE----------------EEKQILKQ---DFETLSQE----TKIQHEELNNRIQTT 837
              T Q                 E K  LKQ    FE   +E     KIQ+E+L  ++Q  
Sbjct: 645  PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL-EKLQEQ 703

Query: 838  VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE---FEKENQKGKAAILDLEKTC 894
            VT+L   + +   + T+L     +   + D+++  + E     + NQK  A     E+  
Sbjct: 704  VTDL---RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQII 760

Query: 895  KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
              +   L+   E  L   +   ++L+KEKE     ++ L+  +E L+  Q          
Sbjct: 761  NTMTQDLRGANEK-LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819

Query: 955  QQLQGNINELKQSSEQK-KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQ---ELAAE 1010
            Q +QG +   +  ++Q+   QIE L+ E+      K +LEN+++Q+ T       +L   
Sbjct: 820  QTIQGILERSETETKQRLSSQIEKLEHEISHL---KKKLENEVEQRHTLTRNLDVQLLDT 876

Query: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ---------- 1060
            K ++    N +  ++E  K  Q        E+   +Q L ++E +++             
Sbjct: 877  KRQLDTETNLHLNTKELLKNAQ-------KEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929

Query: 1061 -----EDLISNRNQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
                 +DL+S   Q   Q N L + LKT+ + +EQ  A     L+E       + KEK +
Sbjct: 930  NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA-MVTSLEE------SLNKEKQV 982

Query: 1115 KEKELVNEKSKLAEIEEIKCRQEK---EITKLNEELKSHKLESIKEI-TNLKDAKQLLIQ 1170
             E+   N + +L E  E + + EK   E+ K  +EL+  K  +I+ +   L + K+ L  
Sbjct: 983  TEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSS 1042

Query: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK 1230
             + E+Q        A+  E++ ++  ++Q K   E   K   E+E  LH+   E     K
Sbjct: 1043 VQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK--YERELMLHAADVEALQAAK 1100

Query: 1231 KHEENEAKLTMQITALNE----NLGTVKKEWQSSQR----RVSELEKQTDDLRGEIAVLE 1282
            +     A +   +    +     L   K  W+  +R     VS+   + +DL  +  +L 
Sbjct: 1101 EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLH 1160

Query: 1283 ATVQNNQDERRALLERCLKGE-----GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
              ++   D+  A ++  ++G       E  K Q ++LE+ R +       +      Q  
Sbjct: 1161 DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE 1220

Query: 1338 QIKHTQALNRKWAEDNEVQNCM 1359
             +++ Q +     E  E+Q+ +
Sbjct: 1221 SLRYRQRVELLERELQELQDSL 1242



 Score =  119 bits (297), Expect = 3e-26
 Identities = 168/830 (20%), Positives = 341/830 (41%), Gaps = 123/830 (14%)

Query: 2    LRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYE 61
            L++ L     +V SQ S       P N  DV                     D+L     
Sbjct: 904  LKQHLSNMEVQVASQSSQRTGKGQPSNKEDV---------------------DDLVSQLR 942

Query: 62   AVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE------- 114
               +  ND     +  L     +V   +  V  L+ SL +EK  +EE++K +E       
Sbjct: 943  QTEEQVNDL----KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998

Query: 115  KYQG-----LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK-QMKDLFEQKAAQL 168
            ++Q      L + E +   L  D    ++S+EQQL E +    +++ ++++  ++ +  L
Sbjct: 999  EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058

Query: 169  ATE-------------IADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELL 215
            + E               + ++KY+ E  L  A  + +    E+++K A+V Q L+    
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE---- 1114

Query: 216  QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
                 E     + +L++ +   +    ERER    LKDE  K   +    E     L  +
Sbjct: 1115 -----ETTQKAESQLLECKASWE----ERER---MLKDEVSKCVCRCEDLEKQNRLLHDQ 1162

Query: 276  LAKGPQEVAVYVQELQK--LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
            + K   +V   V+E  +  L  S++E  +  + + E L    ++    E +     V   
Sbjct: 1163 IEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL 1222

Query: 334  NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
              +  +   + + Q+LQ  L+A             EK + T K   +  E+  K + +  
Sbjct: 1223 RYRQRVELLERELQELQDSLNAER-----------EKVQVTAKTMAQHEELMKKTETMNV 1271

Query: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSEKLMD 450
              +  +  REEKE+    L+ ++ Q+ +K+ + E     L EA+  L E+  +       
Sbjct: 1272 VMETNKMLREEKER----LEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM------- 1320

Query: 451  KEQQVADLQLKLSRLEEQLKE-KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
                   LQ +   LEE +K  K  N   +  Q D   +++++  + ++  T ++++   
Sbjct: 1321 -------LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTE 1373

Query: 510  DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
            ++ ++  +I   +  + N + L+Q  KE+++ +  E+E +   + A       +  +QEK
Sbjct: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK------IIDIQEK 1427

Query: 570  NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV-------QEQKAHLRAAQDRVLSL--- 619
              T+  QV ++  + K Q E  K  Q+ + +         QEQ   ++  Q+   +L   
Sbjct: 1428 VKTIT-QVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486

Query: 620  ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
            ET    L SQ+   ++ +S+ + + +   E  +  ++  +  R DLQ+     +   Q  
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546

Query: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
             ++  K    +    +K+        QL    +E K++  +L+Q+ +EL+ +I  L++  
Sbjct: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQY 1606

Query: 740  LEVKASKEQALQDLQ----QQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
                +  E+ L++ Q    +QR    +   +  E  +Q+ ++    S  R
Sbjct: 1607 EGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGER 1656



 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 113/532 (21%), Positives = 230/532 (43%), Gaps = 42/532 (7%)

Query: 785  RLDLQKKSEALESIKQK-LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
            R +L K  +++++  +K L  Q+ E   LK   E    E++ Q+ E+  R+  +   L  
Sbjct: 11   RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70

Query: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
               E ++L  EL  + ++L  +++  KN + E  ++                     +Q 
Sbjct: 71   ETRECQSLRLELEKLNNQLKALTE--KNKELEIAQDRNIA-----------------IQS 111

Query: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
            Q   T +E +  K+ L +  E   +L  EL  + E + +    LK++   + +LQ  ++E
Sbjct: 112  QFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168

Query: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK---ISVLQNN 1020
            L+ S    K + + L+ E ++   Q T L  +L+   T+  + LA  +EK   I  L+ N
Sbjct: 169  LQASDVSVKYREKRLEQEKELLHSQNTWLNTELK---TKTDELLALGREKGNEILELKCN 225

Query: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
             E  +E   +L+    G ++     ++ ++ +  KL  A+E   S   +  N+     +L
Sbjct: 226  LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKL 285

Query: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
                 +   DS  K  +L    + L  + KE     K +   +  L E+E+ K + EKE+
Sbjct: 286  SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI---QDHLLEVEQSKDQMEKEM 342

Query: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI--LKD 1198
             +    L+  +LE+  ++ +    K  ++ ++ EL   + +  A  +  K   ++  L +
Sbjct: 343  LEKIGRLEK-ELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGMKLTELYN 400

Query: 1199 QVKKEEEELKKEFIEKEA------KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
               + +++L  E +E +       ++  E++ K   +K+  E   +    + +L+  L  
Sbjct: 401  AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ 460

Query: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
              KE Q  Q    +  KQ+  L  +   +E  V++   + R LL    +  G
Sbjct: 461  AMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 84/354 (23%), Positives = 163/354 (46%), Gaps = 37/354 (10%)

Query: 986  VLQKTELENKLQQQLTQAAQE-LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
            VL++TEL NKL + +    ++ LA ++ +I  L+  +EK    FK             + 
Sbjct: 8    VLERTEL-NKLPKSVQNKLEKFLADQQSEIDGLKGRHEK----FK-------------VE 49

Query: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
            + Q    +E++LS +QE L++   +  +    +++L      L + + K+ +  Q+R  A
Sbjct: 50   SEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN-KELEIAQDRNIA 108

Query: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164
               IQ + +  ++EL  EK  L    E   R  +E+  L E++K    E +KE    K  
Sbjct: 109  ---IQSQFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLN-EKLKESNTTKGE 161

Query: 1165 KQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE 1224
             QL +    ELQ    S+K   ++ ++ +++L  Q      ELK +  E  A L  E   
Sbjct: 162  LQLKLD---ELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA-LGREKGN 217

Query: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284
            + + +K + EN+ +   +++ L E +  +K   +  Q+ V +L  +  + + + A +E  
Sbjct: 218  EILELKCNLENKKE---EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274

Query: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
              N   E  A ++     +   +  + K  EL R ++     ++E G  N+++Q
Sbjct: 275  FHN---ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  205 bits (521), Expect = 3e-52
 Identities = 214/1092 (19%), Positives = 482/1092 (44%), Gaps = 44/1092 (4%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E+E   +K+E  +++     SEA   +L  ++    QE      ++Q  + ++N+  +
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            +   L +N ++ E    ++ E+  +E      + A   + + +C +L+  +   E +L +
Sbjct: 906  RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EE++ ++     L  E K LQ+  ++        + ++N L   
Sbjct: 966  VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKS 1025

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
             ++ E+Q+ +  G L++++++     MD E+    L+  L   +E + +   +  +L+ +
Sbjct: 1026 KVKLEQQVDDLEGSLEQEKKVR----MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081

Query: 483  LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
            L K +    +Q +  +       + Q  L++   +I + +++++       K ++  S L
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141

Query: 543  EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH-DQ 601
             +E E++  +++   G T+V  ++ +K     +++ +  E+   Q E+   A    H D 
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
            V E    +   Q     LE   +E   +L++    + Q+   IKAK  L   +   +  Q
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI---IKAKANLEKVSRTLED-Q 1257

Query: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
              + +  L+ AQ +L D   +  K+ T+  ++  +L++K+   SQL      Y ++   L
Sbjct: 1258 ANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL 1317

Query: 722  EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
            +++ EE EG+ K   A +L+        L++ Q + +     EL+   LSK      +  
Sbjct: 1318 KRQLEE-EGKAKNALAHALQSARHDCDLLRE-QYEEETEAKAELQRV-LSKANSEVAQWR 1374

Query: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
            +    D  +++E LE  K+KL ++ ++ +   +         +     L N I+  + ++
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434

Query: 842  QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
            ++      AL  +       L++     + S+SE E   ++ ++   +L K         
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK--------- 1485

Query: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
               ++N  +E  E    LE  K  +  L+ E++ + EQL +    + + EK  +QL+   
Sbjct: 1486 ---LKNAYEESLE---HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEK 1539

Query: 962  NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
             EL+ + E+ +  +E  +G++  A L+  +++ +++++L +  +E+   K     + ++ 
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL 1599

Query: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE-- 1079
            + S +   + +++    + ++     DL  +E +LS A       + Q+ +   L+++  
Sbjct: 1600 QTSLDAETRSRNEVLRVKKKM---EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656

Query: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
            ++   A    D  K+   + ER   L   + E+     E      KLAE E I+  +  +
Sbjct: 1657 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ 1716

Query: 1140 IT-KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD 1198
            +    N  L + K +   ++T L+   +  +Q+    + KA   KA  +     +++ K+
Sbjct: 1717 LLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAK--KAITDAAMMAEELKKE 1774

Query: 1199 QVKKEEEELKKEFIEKEAK--LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE 1256
            Q      E  K+ +E+  K   H   + +++ +K  ++   KL  ++  L   L   +K 
Sbjct: 1775 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKR 1834

Query: 1257 -------WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
                    + S+RR+ EL  QT++ +  +  L+  V   Q + +A   +  + E +    
Sbjct: 1835 NAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN 1894

Query: 1310 QTKVLELQRKLD 1321
             +K  ++Q +LD
Sbjct: 1895 LSKFRKVQHELD 1906



 Score =  204 bits (518), Expect = 6e-52
 Identities = 258/1163 (22%), Positives = 502/1163 (43%), Gaps = 162/1163 (13%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E   IK   ++  + R+  E+K+  L +E N     +Q  +  L       
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907

Query: 222  DVAVLKKELVQVQTLMDNMTLERERE--------SEKLKDECKKLQSQYASSEATISQLR 273
            D  +  K  ++ +    N  LE E E          KL+DEC +L+      E T++++ 
Sbjct: 908  DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967

Query: 274  SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
             E      +V    +E+  L   + +LT++ + L E   +   D    E+K N  S SK 
Sbjct: 968  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027

Query: 334  NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
             ++  +   +   +Q +      E +  ++  +L    E+   L+ +  ++E K +  + 
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087

Query: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE---------------------RQLGE 432
            +  Q   + E+++   LQLQ ++ +  +++ E E                     R+L E
Sbjct: 1088 DINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1147

Query: 433  AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE----------QLKEKVTNS-TELQH 481
               RL+E    +S ++   +++ A+ Q     LEE           L++K  +S  EL  
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1207

Query: 482  QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
            Q+D  ++  Q+ +  +     +L +  +++EQ+++   + ++  + LE    + +  +  
Sbjct: 1208 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEE 1267

Query: 542  LEKEREDL---YAKIQAGEGETAVLNQLQEKNHTLQE------QVTQLTEKLKNQSESHK 592
             ++   D     AK+Q   GE A   QL+EK   + +        TQ  E LK Q E   
Sbjct: 1268 AQRSLNDFTTQRAKLQTENGELA--RQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325

Query: 593  QAQENL--------HD-----QVQEQKAHLRAAQDRVLS------------LETSVNELN 627
            +A+  L        HD     +  E++   +A   RVLS             ET   +  
Sbjct: 1326 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1385

Query: 628  SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
             +L E+K+K++Q           L  AE A  A  A   + L+  ++ LQ++ ++L    
Sbjct: 1386 EELEEAKKKLAQ----------RLQDAEEAVEAVNAKCSS-LEKTKHRLQNEIEDLMVDV 1434

Query: 688  TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747
             + +   A L  KQ +  ++   L E+K+KY   + + E  + + + L  +  ++K + E
Sbjct: 1435 ERSNAAAAALDKKQRNFDKI---LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491

Query: 748  QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
            ++L+ L+  ++ N +L+   ++L++QL            +  K    LE ++++L   E 
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLG-----------EGGKNVHELEKVRKQL---EV 1537

Query: 808  EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT----ELSTVKDKLS 863
            EK  L+   E    E  ++HEE   +I     E  ++K E E  +     E+   K    
Sbjct: 1538 EKLELQSALE--EAEASLEHEE--GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKE 922
            +V DSL+ S               LD E   +    +++ +ME  L E + +L  +    
Sbjct: 1594 RVVDSLQTS---------------LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMA 1638

Query: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
             EA  Q+K   + +++  IQ  + ++ N+     L+ NI  +++ +   + ++E L+   
Sbjct: 1639 AEAQKQVKSLQSLLKDTQIQLDDAVRAND----DLKENIAIVERRNNLLQAELEELR--- 1691

Query: 983  KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
              AV+++TE   KL      A QEL    E++ +L +         K+++SD    +SE+
Sbjct: 1692 --AVVEQTERSRKL------AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743

Query: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
                Q+ ++ EEK   A  D      ++  +      L+  K  +EQ      + LQ R 
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI----KDLQHRL 1799

Query: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIE-EIKCRQEKEITKLNEELKSHKLESIKEIT-- 1159
               + I  +    +K+L   ++++ E+E E++  Q++    +    KS +   IKE+T  
Sbjct: 1800 DEAEQIALKGG--KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSER--RIKELTYQ 1855

Query: 1160 NLKDAKQLL----IQQKLELQGKADSLKAAVEQEKRN---QQILKDQVKKEEEELKKEFI 1212
              +D K LL    +  KL+L+ KA   +A   +E+ N    +  K Q + +E E + +  
Sbjct: 1856 TEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIA 1915

Query: 1213 EKEA-KLHSEIKEKEVGMKKHEE 1234
            E +  KL ++ ++     K H+E
Sbjct: 1916 ESQVNKLRAKSRDIGAKQKMHDE 1938



 Score =  185 bits (470), Expect = 2e-46
 Identities = 228/1063 (21%), Positives = 467/1063 (43%), Gaps = 159/1063 (14%)

Query: 383  EVETKYQHLKAEFKQLQQQREE--------------KEQHGLQLQSEINQLHSKLLETER 428
            + + + Q ++ EFK++ ++R+               K    ++L  +I  L  K  ETE+
Sbjct: 791  QAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPL-LKSAETEK 849

Query: 429  QLG---EAHGRLKE-------QRQLSSEKLMDKEQQVADLQLK-------LSRLEEQLKE 471
            ++    E  GR+KE       +R+   EK++   Q+  DLQL+       L+  EE+  +
Sbjct: 850  EMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQ 909

Query: 472  KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL 531
             + N  +L+ ++ +  ++ ++++ +    TAK R+ +++  ++ + I D       LE  
Sbjct: 910  LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDD-------LELT 962

Query: 532  LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591
            L K       +EKE+     K++           L E+   L E + +LT++ K   E+H
Sbjct: 963  LAK-------VEKEKHATENKVK----------NLTEEMAGLDEIIAKLTKEKKALQEAH 1005

Query: 592  KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
            +QA ++L  QV+E K                VN L+    + +++V  L+  ++ + ++ 
Sbjct: 1006 QQALDDL--QVEEDK----------------VNSLSKSKVKLEQQVDDLEGSLEQEKKVR 1047

Query: 652  LSAEAAKTAQRADLQNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQEHCSQLE 708
            +  E AK     DL+   ++  +   DK   +++L K    ++Q  +K++D+Q    QL+
Sbjct: 1048 MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQ 1107

Query: 709  SHLKEYKEKYLSLEQKTEE---LEGQIKKLEADSL----EVKASKEQALQDLQQQRQLNT 761
              LKE + +   LE++ E       +++KL +D      E+    E+A      Q ++N 
Sbjct: 1108 KKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167

Query: 762  DLELRATELSKQLEMEKEIVSSTRLDLQKKS-----------EALESIKQKLTKQEEE-- 808
              E    ++ + LE       +T   L+KK            + L+ +KQKL K++ E  
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1227

Query: 809  ----------KQILK---------QDFETLSQETKIQHEE----LNN------RIQTTVT 839
                      +QI+K         +  E  + E +++ EE    LN+      ++QT   
Sbjct: 1228 LELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENG 1287

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
            EL +   EKEAL+++L+  K   ++  + LK    E  K       A+      C  L+ 
Sbjct: 1288 ELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE 1347

Query: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQNEKEEQQL 957
            Q + + E   + Q+ L K+    + A  + K E +++Q  E+L +A+  L Q  ++ ++ 
Sbjct: 1348 QYEEETEAKAELQRVLSKA--NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1405

Query: 958  QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
               +N    S E+ K +++    +L + V +       L ++     + LA  K+K    
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465

Query: 1018 QNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLI 1077
            Q+  E SQ+  + L ++ +  ++    + + L++ + +    QE++     Q+G   K +
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525

Query: 1078 QELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE 1137
             EL+  +  LE +  + +  L+E          E SL+ +E    +++L E  +IK   E
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEE---------AEASLEHEEGKILRAQL-EFNQIKAEIE 1575

Query: 1138 KEITKLNEELKSHKLESIKEITNLKD-------AKQLLIQQKLELQGKADSLKAAVEQEK 1190
            +++ + +EE++  K    + + +L+        ++  +++ K +++G  + ++  +    
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635

Query: 1191 RNQQILKDQVKKEEEELKKEFIE--------KEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
            R     + QVK  +  LK   I+         + K +  I E+   + + E  E +  ++
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695

Query: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKG 1302
             T  +  L   ++E   +  RV  L  Q   L  +   +E+ +   Q E    ++ C   
Sbjct: 1696 QTERSRKL--AEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNA 1753

Query: 1303 EGEIEKLQTKVLELQRKL--DNTTAAVQELGRENQSLQIKHTQ 1343
            E + +K  T    +  +L  +  T+A  E  ++N    IK  Q
Sbjct: 1754 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1796



 Score =  177 bits (448), Expect = 8e-44
 Identities = 208/1007 (20%), Positives = 434/1007 (43%), Gaps = 128/1007 (12%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE- 146
            L Q+V DL+ SL++EK    +L++   K +G  +       L  +S  +L++ + QLEE 
Sbjct: 1029 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK-------LTQESIMDLENDKLQLEEK 1081

Query: 147  AQTENFNIKQMKDLFEQK---AAQLATEIADIKSK---YDEERSLREAAEQKVTRLTEEL 200
             + + F+I Q     E +   A QL  ++ + +++    +EE      A  KV +L  +L
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141

Query: 201  NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
            ++E   ++++   L +  G   V +              M  +RE E +K++ + ++   
Sbjct: 1142 SRE---LEEISERLEEAGGATSVQI-------------EMNKKREAEFQKMRRDLEEATL 1185

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q+   EAT + LR + A    E+   +  LQ++K                         K
Sbjct: 1186 QH---EATAAALRKKHADSVAELGEQIDNLQRVKQ------------------------K 1218

Query: 321  LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
            LE++ +E  +   ++ + + Q       L+      E   +   V+L E        +  
Sbjct: 1219 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEE-------AQRS 1271

Query: 381  LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
            L++  T+   L+ E  +L +Q EEKE       + I+QL    L   +Q+ +   +L+E+
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKE-------ALISQLTRGKLSYTQQMEDLKRQLEEE 1324

Query: 441  RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ------HQEQQ 494
             +  +      +    D  L    L EQ +E+     ELQ  L K   +        E  
Sbjct: 1325 GKAKNALAHALQSARHDCDL----LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1380

Query: 495  ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ 554
            A+Q+  T +L EA+  L Q L+   D ++ ++ + A     ++    L+ E EDL   ++
Sbjct: 1381 AIQR--TEELEEAKKKLAQRLQ---DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435

Query: 555  AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV-------QEQKA 607
                  A L++ Q     +  +  Q  E+ +++ ES ++   +L  ++       +E   
Sbjct: 1436 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1495

Query: 608  HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
            HL   +    +L+  +++L  QL E  + V +L+   K + +L          ++ +LQ+
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELE---KVRKQL--------EVEKLELQS 1544

Query: 668  HLDTAQNALQDKQQELNKITTQLDQVTA----KLQDKQEHCSQLE-SHLKEYKEKYLSLE 722
             L+ A+ +L+ ++ ++ +   + +Q+ A    KL +K E   Q + +H +       SL+
Sbjct: 1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD 1604

Query: 723  QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
             +T        +   + L VK   E  L +++ Q    +     A E  KQ++  + ++ 
Sbjct: 1605 AET--------RSRNEVLRVKKKMEGDLNEMEIQL---SHANRMAAEAQKQVKSLQSLLK 1653

Query: 783  STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS---QETKIQHEELNNRIQTTVT 839
             T++ L     A + +K+ +   E    +L+ + E L    ++T+   +     +  T  
Sbjct: 1654 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1713

Query: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
             +Q +  +  +L+ +   ++  L+++   ++ +  E     +K K AI D     +ELK 
Sbjct: 1714 RVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1773

Query: 900  Q--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
            +      +E   K  ++  K L+   + + Q+ L+    Q Q ++A+    + E E +Q 
Sbjct: 1774 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQ- 1832

Query: 958  QGNINELK--QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS 1015
            + N   +K  + SE++ K++     E K  +L+  +L +KLQ ++    ++    +E+ +
Sbjct: 1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1892

Query: 1016 VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
               + + K Q    + +      ES++   R   + +  K  +  E+
Sbjct: 1893 TNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDEE 1939



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 78/347 (22%), Positives = 143/347 (41%), Gaps = 59/347 (17%)

Query: 45   QCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKE--- 101
            +  K + S   L K  +   D    +    + N+A+      LL+ E+++L+A +++   
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1699

Query: 102  -EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160
              K   +EL +  E+ Q L  Q            ++L  L+ ++EEA  E  N       
Sbjct: 1700 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNA------ 1753

Query: 161  FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
             E+KA +  T+ A                      + EEL KE    QD    L +    
Sbjct: 1754 -EEKAKKAITDAA---------------------MMAEELKKE----QDTSAHLER---- 1783

Query: 221  EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
                 +KK +   QT+ D      E E   LK   K+LQ      EA + +L  EL    
Sbjct: 1784 -----MKKNM--EQTIKDLQHRLDEAEQIALKGGKKQLQ----KLEARVRELEGELEAEQ 1832

Query: 281  QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE------EKHNEESVSKKN 334
            +  A  V+ ++K +  + ELT + +   +NLL+ +    KL+      ++  EE+  + N
Sbjct: 1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1892

Query: 335  IQATLHQK-DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
               +  +K   +  + + R   +E+ ++++  +  + G A QK+ +E
Sbjct: 1893 TNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG-AKQKMHDE 1938


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  204 bits (520), Expect = 4e-52
 Identities = 224/1127 (19%), Positives = 503/1127 (44%), Gaps = 90/1127 (7%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            ERE+E   +K+E  +L+     SEA   +L  ++    QE      ++Q  + ++ +  +
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            +   L +N ++ E    ++ E+  +E      + A   + + +C +L+  +   E +L +
Sbjct: 904  RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EE++ ++     L  E K LQ+  ++        + ++N L   
Sbjct: 964  VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDK----------EQQVADLQLKLSRLEEQLKEK 472
             ++ E+Q+ +  G L++++++  +    K          ++ + DL+    +L+E+LK+K
Sbjct: 1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
                     +L+    + +++QAL      KL+E Q  +E++  ++    +  +   A +
Sbjct: 1084 -------DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL----EAERTARAKV 1132

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
            +K + ++S   +E E++  +++   G T+V  ++ +K     +++ +  E+   Q E+  
Sbjct: 1133 EKLRSDLS---RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189

Query: 593  QAQENLH-DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
             A    H D V E    +   Q     LE   +E   +L++    + Q+   IKAK  L 
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI---IKAKANLE 1246

Query: 652  LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
                  +  Q  + ++  +  Q ++ D   +  K+ T+  +++ +L +K+   SQL    
Sbjct: 1247 KMCRTLED-QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK 1305

Query: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
              Y ++   LE    +LE ++K   A +  +++++     DL ++ Q   + E +A EL 
Sbjct: 1306 LTYTQQ---LEDLKRQLEEEVKAKNALAHALQSARHDC--DLLRE-QYEEETEAKA-ELQ 1358

Query: 772  KQLEMEKEIVSSTRL----DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
            + L      V+  R     D  +++E LE  K+KL ++ +E +   +         +   
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK 1418

Query: 828  EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
              L N I+  + ++++      AL  +       L++     + S+SE E   ++ ++  
Sbjct: 1419 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1478

Query: 888  LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
             +L K            ++N  +E  E    LE  K  +  L+ E++ + EQL  +  T+
Sbjct: 1479 TELFK------------LKNAYEESLE---HLETFKRENKNLQEEISDLTEQLGSSGKTI 1523

Query: 948  KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
             + EK  +QL+    EL+ + E+ +  +E  +G++  A L+  +++ +++++L +  +E+
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1583

Query: 1008 AAEKEK----ISVLQNNYE-------KSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
               K      +  LQ + +       ++    K+++ D    E +L    +     ++++
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1643

Query: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
               Q  L   + Q+ +  +   +LK   A +E+ +   + +L+E    ++  ++ + L E
Sbjct: 1644 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703

Query: 1117 KELV--NEKSKLAEIEEIKC-RQEKEITKLNEELKSHKLESIKEITNLKD-AKQLLIQQK 1172
            +EL+  +E+ +L   +      Q+K++     +L++   E+++E  N ++ AK+ +    
Sbjct: 1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763

Query: 1173 L---ELQGKADSLKAAVEQEKRNQQILKD---------QV-----KKEEEELKKEFIEKE 1215
            +   EL+ + D+       +K  +Q +KD         Q+     KK+ ++L+    E E
Sbjct: 1764 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1823

Query: 1216 AKLHSEIK---EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
             +L +E K   E   GM+K E    +LT Q     +NL  ++      Q +V   ++Q +
Sbjct: 1824 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAE 1883

Query: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
            +   +     +  +  Q E     ER    E ++ KL+ K  ++  K
Sbjct: 1884 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930



 Score =  203 bits (517), Expect = 8e-52
 Identities = 234/1133 (20%), Positives = 497/1133 (43%), Gaps = 112/1133 (9%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E   +K   ++  + R+  E+K+  L +E N     +Q  +  L       
Sbjct: 846  EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905

Query: 222  DVAVLKKELVQVQTLMDNMTLERERE--------SEKLKDECKKLQSQYASSEATISQLR 273
            D  +  K  ++ +    N  LE E E          KL+DEC +L+      E T++++ 
Sbjct: 906  DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE 965

Query: 274  SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKK 333
             E      +V    +E+  L   + +LT++ + L E   +   D    E+K N  + +K 
Sbjct: 966  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025

Query: 334  NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
             ++  +   +   +Q +      E +  ++  +L    E+   L+ +  +++ + +    
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085

Query: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
            E   L  + E+++  G QLQ ++ +L +++ E E +L        E  + +  K+   E+
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL--------EAERTARAKV---EK 1134

Query: 454  QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ-------QHQEQQALQ-QSTTAKLR 505
              +DL  +L  + E+L E+   +T +Q +++K ++       +  E+  LQ ++T A LR
Sbjct: 1135 LRSDLSRELEEISERL-EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193

Query: 506  EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
            +   D       + +  ++I NL+ + QK       LEKE+ +   ++   +  T+ + Q
Sbjct: 1194 KKHAD------SVAELGEQIDNLQRVKQK-------LEKEKSEFKLEL---DDVTSNMEQ 1237

Query: 566  LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
            + +    L++    L +++       ++ Q +++D +  Q+A L+     +         
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND-LTSQRAKLQTENGELSRQLDEKEA 1296

Query: 626  LNSQLNESK--------EKVSQLDIQIKAKTELLLSAEAAKTAQRAD-LQNHLDTAQNAL 676
            L SQL   K        +   QL+ ++KAK  L  + ++A+     D L+   +    A 
Sbjct: 1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR--HDCDLLREQYEEETEAK 1354

Query: 677  QDKQQELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
             + Q+ L+K  +++ Q   K + D  +   +LE   K+  ++    E+  E +  +   L
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414

Query: 736  EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
            E     ++   E  + D+++       L+ +     K L   K+    ++ +L+   +  
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEA 1474

Query: 796  ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ------TTVTELQKVKMEKE 849
             S+  +L K +   +   +  ET  +E K   EE+++  +       T+ EL+KV+ + E
Sbjct: 1475 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLE 1534

Query: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
            A   EL +    L +   SL++ + +  +   +      ++E+   E   +++    N L
Sbjct: 1535 AEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591

Query: 910  KEQKELKKSLEKEKEASHQ-------LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI- 961
            +    L+ SL+ E  + ++       ++ +LN M+ QL  A     + +K+ + LQ  + 
Sbjct: 1592 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651

Query: 962  -------------NELKQSSEQKKKQIEALQGELK--IAVLQKTELENKLQQQLTQAAQE 1006
                         ++LK++    +++   LQ EL+   AV+++TE   KL      A QE
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL------AEQE 1705

Query: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
            L    E++ +L +         K++ +D    ++E+    Q+ ++ EEK   A  D    
Sbjct: 1706 LIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM 1765

Query: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
              ++  +      L+  K  +EQ      + LQ R    + I  +    +K+L   ++++
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTI----KDLQHRLDEAEQIALKGG--KKQLQKLEARV 1819

Query: 1127 AEIE-EIKCRQEKEITKLNEELKSHKLESIKEIT--NLKDAKQLL----IQQKLELQGKA 1179
             E+E E++  Q++    +    KS +   IKE+T    +D K LL    +  KL+L+ KA
Sbjct: 1820 RELENELEAEQKRNAESVKGMRKSER--RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKA 1877

Query: 1180 DSLKAAVEQEKRNQQILK-DQVKKEEEELKKEFIEKEAKLHS-EIKEKEVGMK 1230
               +A   +E+ N  + K  +V+ E +E ++     E++++    K +++G K
Sbjct: 1878 YKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930



 Score =  187 bits (474), Expect = 8e-47
 Identities = 206/972 (21%), Positives = 436/972 (44%), Gaps = 93/972 (9%)

Query: 447  KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
            K  ++E+++A ++ + +RL+E L++      EL+ ++    Q+  + Q   Q+    L +
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900

Query: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKE-NISLLEKER--EDLYAKIQAGEGETAV- 562
            A+   +Q+++     + K++ +   L+  +E N  L  K+R  ED  ++++    +  + 
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960

Query: 563  LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
            L +++++ H  + +V  LTE++    E   +  +   ++   Q+AH +A  D + + E  
Sbjct: 961  LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK---EKKALQEAHQQALDD-LQAEEDK 1016

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ- 681
            VN L     + +++V  L+  ++ + ++ +  E AK     DL+   ++  +   DKQQ 
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076

Query: 682  --ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE---LEGQIKKLE 736
               L K   +L+ + A+++D+Q   SQL+  LKE + +   LE++ E       +++KL 
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136

Query: 737  ADSL----EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
            +D      E+    E+A      Q ++N   E    ++ + LE       +T   L+KK 
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196

Query: 793  -----------EALESIKQKLTKQEEE------------KQILK---------------- 813
                       + L+ +KQKL K++ E            +QI+K                
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256

Query: 814  QDFETLSQETKIQHEELNN---RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
             +  + ++ET+    +L +   ++QT   EL +   EKEAL+++L+  K   ++  + LK
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316

Query: 871  NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
                E  K       A+      C  L+ Q + + E   + Q+ L K+    + A  + K
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA--NSEVAQWRTK 1374

Query: 931  LELNSMQ--EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
             E +++Q  E+L +A+  L Q  +E ++    +N    S E+ K +++    +L + V +
Sbjct: 1375 YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1434

Query: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
                   L ++     + LA  K+K    Q+  E SQ+  + L ++ +  ++    + + 
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494

Query: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1108
            L++ + +    QE++     Q+G+  K I EL+  +  LE +  + +  L+E        
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE-------- 1546

Query: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD----- 1163
              E SL+ +E    +++L E  +IK   E+++ + +EE++  K   ++ + +L+      
Sbjct: 1547 -AEASLEHEEGKILRAQL-EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE 1604

Query: 1164 --AKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE-------- 1213
              ++   ++ K +++G  + ++  +    R     + QVK  +  LK   I+        
Sbjct: 1605 TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1664

Query: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD 1273
             + K +  I E+   + + E  E +  ++ T  +  L   ++E   +  RV  L  Q   
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL--AEQELIETSERVQLLHSQNTS 1722

Query: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL--DNTTAAVQELG 1331
            L  +   ++A +   Q E    ++ C   E + +K  T    +  +L  +  T+A  E  
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782

Query: 1332 RENQSLQIKHTQ 1343
            ++N    IK  Q
Sbjct: 1783 KKNMEQTIKDLQ 1794



 Score =  182 bits (462), Expect = 2e-45
 Identities = 216/1003 (21%), Positives = 443/1003 (44%), Gaps = 134/1003 (13%)

Query: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE- 146
            L Q+V DL+ SL++EK    +L++   K +G  +       L  +S  +L++ +QQL+E 
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK-------LTQESIMDLENDKQQLDER 1079

Query: 147  AQTENFNIKQMKDLFEQKAA---QLATEIADIKSK---YDEERSLREAAEQKVTRLTEEL 200
             + ++F +  +    E + A   QL  ++ +++++    +EE      A  KV +L  +L
Sbjct: 1080 LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDL 1139

Query: 201  NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
            ++E   ++++   L +  G   V +              M  +RE E +K++ + ++   
Sbjct: 1140 SRE---LEEISERLEEAGGATSVQI-------------EMNKKREAEFQKMRRDLEEATL 1183

Query: 261  QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
            Q+   EAT + LR + A    E+   +  LQ++K                 L+KE+   K
Sbjct: 1184 QH---EATAAALRKKHADSVAELGEQIDNLQRVKQK---------------LEKEKSEFK 1225

Query: 321  LE---EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
            LE      N E + K   +A L +    C+ L+ +++           E   K E TQ+ 
Sbjct: 1226 LELDDVTSNMEQIIK--AKANLEKM---CRTLEDQMN-----------EHRSKAEETQRS 1269

Query: 378  KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
              +L+    K   L+ E  +L +Q +EKE       + I+QL    L   +QL +   +L
Sbjct: 1270 VNDLTSQRAK---LQTENGELSRQLDEKE-------ALISQLTRGKLTYTQQLEDLKRQL 1319

Query: 438  KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ------HQ 491
            +E+ +  +      +    D  L    L EQ +E+     ELQ  L K   +        
Sbjct: 1320 EEEVKAKNALAHALQSARHDCDL----LREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

Query: 492  EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA 551
            E  A+Q+  T +L EA+  L Q L++  +  + +    + L+K+K     L+ E EDL  
Sbjct: 1376 ETDAIQR--TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR---LQNEIEDLMV 1430

Query: 552  KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV-------QE 604
             ++      A L++ Q     +  +  Q  E+ +++ ES ++   +L  ++       +E
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490

Query: 605  QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
               HL   +    +L+  +++L  QL  S + + +L+   K + +L         A++ +
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE---KVRKQL--------EAEKME 1539

Query: 665  LQNHLDTAQNALQDKQQELNKITTQLDQVTA----KLQDKQEHCSQLE-SHLKEYKEKYL 719
            LQ+ L+ A+ +L+ ++ ++ +   + +Q+ A    KL +K E   Q + +HL+       
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599

Query: 720  SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
            SL+ +T        +   ++L VK   E  L +++ Q    +     A E  KQ++  + 
Sbjct: 1600 SLDAET--------RSRNEALRVKKKMEGDLNEMEIQL---SHANRMAAEAQKQVKSLQS 1648

Query: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS---QETKIQHEELNNRIQT 836
            ++  T++ L     A + +K+ +   E    +L+ + E L    ++T+   +     +  
Sbjct: 1649 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1708

Query: 837  TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
            T   +Q +  +  +L+ +   +   LS++   ++ +  E     +K K AI D     +E
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768

Query: 897  LKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954
            LK +      +E   K  ++  K L+   + + Q+ L+    Q Q ++A+    +NE E 
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828

Query: 955  QQLQGNINELK--QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
            +Q + N   +K  + SE++ K++     E +  +L+  +L +KLQ ++    ++    +E
Sbjct: 1829 EQ-KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887

Query: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
            + +   + + K Q    + +      ES++   R   + +  K
Sbjct: 1888 QANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 79/347 (22%), Positives = 143/347 (41%), Gaps = 60/347 (17%)

Query: 45   QCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKE--- 101
            +  K + S   L K  +   D    +    + N+A+      LL+ E+++L+A +++   
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697

Query: 102  -EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160
              K   +EL +  E+ Q L  Q            A+L  L+ ++EEA  E  N       
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA------ 1751

Query: 161  FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
             E+KA +  T+ A                      + EEL KE    QD    L +    
Sbjct: 1752 -EEKAKKAITDAA---------------------MMAEELKKE----QDTSAHLER---- 1781

Query: 221  EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
                 +KK +   QT+ D      E E   LK   K+LQ      EA + +L +EL    
Sbjct: 1782 -----MKKNM--EQTIKDLQHRLDEAEQIALKGGKKQLQ----KLEARVRELENELEAEQ 1830

Query: 281  QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE------EKHNEESVSKKN 334
            +  A  V+ ++K +  + ELT + +   +NLL+ +    KL+      ++  EE+  + N
Sbjct: 1831 KRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1890

Query: 335  IQATLHQK-DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
               +  +K   +  + + R   +E+ ++++  +  + G  T+ L EE
Sbjct: 1891 TNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG--TKGLNEE 1935



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 56/226 (24%), Positives = 96/226 (42%), Gaps = 59/226 (26%)

Query: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
            +EKE+  + EE            T LK+A +    ++ EL+ K  SL     QEK + Q+
Sbjct: 845  REKEMASMKEEF-----------TRLKEALEKSEARRKELEEKMVSLL----QEKNDLQL 889

Query: 1196 LKDQVKKEEEELKK------EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
               QV+ E++ L        + I+ + +L +++KE    ++  EE  A+LT +   L + 
Sbjct: 890  ---QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946

Query: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
                           SEL++  DDL   +A                     K E E    
Sbjct: 947  C--------------SELKRDIDDLELTLA---------------------KVEKEKHAT 971

Query: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
            + KV  L  ++      + +L +E ++LQ  H QAL+   AE+++V
Sbjct: 972  ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  204 bits (519), Expect = 5e-52
 Identities = 244/1162 (20%), Positives = 513/1162 (44%), Gaps = 130/1162 (11%)

Query: 162  EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE 221
            E++ A +  E    K +  +  + R+  E+K+  L +E N     +Q     LL     E
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE--E 904

Query: 222  DVAVLKKELVQVQTLMDNMTLERERESE----------KLKDECKKLQSQYASSEATISQ 271
                L K   Q++  +  +T   E E E          KL+DEC +L+      E T+++
Sbjct: 905  RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +  E      +V    +EL  L  ++ +LT++ + L E   +   D    E+K N  + +
Sbjct: 965  VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 332  KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
            K  ++  +   +   +Q +      E +  ++  +L    E+   L+ +  +++ + +  
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084

Query: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL-GEAHGRLKEQRQLSSEKLMD 450
              E+ QLQ + E+++  GLQ Q +I +L +++ E E ++  E   R K ++Q S     D
Sbjct: 1085 DFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS-----D 1139

Query: 451  KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
              +++ +L  +L         ++  + + + +  K ++  +E     ++  A LR+   D
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199

Query: 511  LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
                   + +  ++I NL+ + QK ++  S  + E +DL + +++     A    L++  
Sbjct: 1200 ------SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA---NLEKIC 1250

Query: 571  HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
             TL++Q+++   K               ++++Q   + L   + R   L+T   EL+ QL
Sbjct: 1251 RTLEDQLSEARGK---------------NEEIQRSLSELTTQKSR---LQTEAGELSRQL 1292

Query: 631  NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA-QNALQDKQQELNKITTQ 689
             E +  VSQL    +A T+     +  +  ++ + +N    A  +ALQ  + + + +  Q
Sbjct: 1293 EEKESIVSQLSRSKQAFTQ-----QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQ 1347

Query: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
             ++      + Q   S+  S + +++ KY     Q+TEELE   KKL            Q
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-----------AQ 1396

Query: 749  ALQDLQQQRQLNTDLELRATELSKQ--------LEMEKEIVSSTRLDLQKKSEALESIKQ 800
             LQD ++Q +   + +  + E +KQ        L ++ E  +S    L KK    + +  
Sbjct: 1397 RLQDSEEQVEA-VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
            +   + EE Q   +     S+    +  +L N  +  + +L+ VK E + L  E++ + +
Sbjct: 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515

Query: 861  KLS---KVSDSLKNSKSEFEKENQKGKAAI-LDLEKTCKELKHQ----LQVQMENTLKEQ 912
            +++   K    L+ S+ + E E    KA I L LE+    L+H+    L++Q+E T + +
Sbjct: 1516 QIAENGKTIHELEKSRKQIELE----KADIQLALEEAEAALEHEEAKILRIQLELT-QVK 1570

Query: 913  KELKKSLEKEKEASHQLKLE----LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK--- 965
             E+ + + ++ E   QLK      + +MQ  L     +  +  + +++++G++NE++   
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630

Query: 966  ----QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
                + + +  K + ++QG+LK   L    L++ L+ Q     ++LA  + + ++LQ   
Sbjct: 1631 SHANRQAAETLKHLRSVQGQLKDTQL---HLDDALRGQ-EDLKEQLAIVERRANLLQAEV 1686

Query: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081
            E+ + T +Q +      E ELL + + ++ +  +          N + I  + KL  +L 
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQ----------NTSLIHTKKKLETDLM 1736

Query: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
              ++ +E  S       ++  KA+ D     ++  +EL  E+   A +E +K   E+ + 
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITD----AAMMAEELKKEQDTSAHLERMKKNLEQTVK 1792

Query: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
             L      H+L+  +++      KQ+   QKLE + +    +   EQ+K  + +    ++
Sbjct: 1793 DL-----QHRLDEAEQLALKGGKKQI---QKLETRIRELEFELEGEQKKNTESV--KGLR 1842

Query: 1202 KEEEELKKEFIEKE------AKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
            K E  +K+   + E       +L   + + +V +K ++    +   Q  A        + 
Sbjct: 1843 KYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902

Query: 1256 EWQSSQRRVSELEKQTDDLRGE 1277
            E + ++ R    E Q + LR +
Sbjct: 1903 ELEEAEERADIAESQVNKLRAK 1924



 Score =  197 bits (500), Expect = 8e-50
 Identities = 234/1135 (20%), Positives = 512/1135 (45%), Gaps = 130/1135 (11%)

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E+E   +K+E +K + + A SEA   +L  +L    QE      ++Q    ++ +  +
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904

Query: 303  KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
            +   L +   + E    ++ E+  +E      + A   + + +C +L+  +   E +L +
Sbjct: 905  RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964

Query: 363  IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
            +  E        + L EELS ++     L  E K LQ+  ++        + ++N L+  
Sbjct: 965  VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDK----------EQQVADLQLKLSRLEEQLKEK 472
              + E+Q+ +    L+++++L  +   +K          ++ + DL+    +L+E+LK+K
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
                 +LQ +++       ++Q L      K++E Q  +E++       +++I+   A  
Sbjct: 1085 DFEYCQLQSKVE-------DEQTLGLQFQKKIKELQARIEEL-------EEEIEAERATR 1130

Query: 533  QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
             K+++  S   +E E+L  +++   G T+   +L +K    + +  +L   L+  +  H+
Sbjct: 1131 AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR---EAEFLKLRRDLEEATLQHE 1187

Query: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
                 L  +  +  A L    +++ +L+    +L  + +E K ++  L   +++ ++   
Sbjct: 1188 AMVAALRKKHADSVAEL---GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244

Query: 653  SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
            + E         L++ L  A+   ++ Q+ L+++TTQ  ++  +  +      + ES + 
Sbjct: 1245 NLEKICRT----LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300

Query: 713  EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
            +      +  Q+TEEL+ Q        LE +   + AL    Q  + + DL      L +
Sbjct: 1301 QLSRSKQAFTQQTEELKRQ--------LEEENKAKNALAHALQSSRHDCDL------LRE 1346

Query: 773  QLEMEKEIVSSTRLDLQKK-SEALESIKQKLTKQE-------EEKQILKQDFETLSQETK 824
            Q E E+E     + +LQ+  S+A   + Q  TK E       EE +  K+      Q+++
Sbjct: 1347 QYEEEQE----GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE 1402

Query: 825  IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGK 884
             Q E +N +  +     Q+++ E E LM ++    ++ + ++ +L   +  F+K      
Sbjct: 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDV----ERANSLAAALDKKQRNFDK------ 1452

Query: 885  AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
              + + +  C+E     Q ++E +LKE + L   L K K          N+ +E L Q +
Sbjct: 1453 -VLAEWKTKCEE----SQAELEASLKESRSLSTELFKLK----------NAYEEALDQLE 1497

Query: 945  NTLKQNEKEEQQLQGNINELKQSS------EQKKKQIEALQGELKIAVLQ-KTELEN--- 994
               ++N+  EQ++     ++ ++       E+ +KQIE  + ++++A+ + +  LE+   
Sbjct: 1498 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEA 1557

Query: 995  ---KLQQQLTQAAQE----LAAEKEKISVLQNNYEKSQETFKQ-LQSDFYGRESELLATR 1046
               ++Q +LTQ   E    +A + E+I  L+ NY+++ ET +  L ++   R   +   +
Sbjct: 1558 KILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 1617

Query: 1047 Q---DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
            +   DL  +E +LS A          +     +  +LK  +  L+ D+ + ++ L+E+  
Sbjct: 1618 KMEGDLNEIEIQLSHANRQAAETLKHL---RSVQGQLKDTQLHLD-DALRGQEDLKEQ-- 1671

Query: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163
             L  +++  +L + E+   ++ L + E  +   E+E+   NE ++    ++   I   K 
Sbjct: 1672 -LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKK 1730

Query: 1164 AKQLLIQQKLELQGKADSLKAAVEQEKR---NQQILKDQVKKEE------EELKKEFIEK 1214
             +  L+Q + E++  +   + A E+ K+   +  ++ +++KKE+      E +KK   + 
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790

Query: 1215 EAKLHSEIKEKE-VGMKKHEENEAKLTMQITALNENL-GTVKKEWQS------SQRRVSE 1266
               L   + E E + +K  ++   KL  +I  L   L G  KK  +S       +RRV E
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850

Query: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
            L  Q+++ R  +  L+  V   Q + ++   +  + + +     TK  + Q +L+
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905



 Score =  189 bits (480), Expect = 2e-47
 Identities = 231/1076 (21%), Positives = 476/1076 (44%), Gaps = 115/1076 (10%)

Query: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKE----ELSEVETKYQH------LKAEF 395
            C++L + +    T     H ++  K      L+E     L+++ T+ Q       ++ EF
Sbjct: 743  CEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEF 802

Query: 396  KQLQQQREEKEQHGLQLQSEINQLH---SKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
            +++ Q+RE        ++S +N  H    KL    + L ++    KE   +  E    K+
Sbjct: 803  QKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKD 862

Query: 453  QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDL 511
            + +A  + K   LEE+L   V    +LQ Q+    +   + ++   Q   AK  + +  +
Sbjct: 863  E-LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF-QLEAKI 920

Query: 512  EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL---YAKIQAGEGETA-VLNQLQ 567
            ++V  +  D+++    L A  +K ++  S L+K+ +DL    AK++  +  T   +  L 
Sbjct: 921  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 980

Query: 568  EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
            E+   L E + +LT + K   E+H+QA ++L  Q +E K                VN LN
Sbjct: 981  EELSGLDETIAKLTREKKALQEAHQQALDDL--QAEEDK----------------VNSLN 1022

Query: 628  SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ---ELN 684
               ++ +++V  L+  ++ + +L +  E  K     DL+   ++  +   DKQQ    L 
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082

Query: 685  KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
            K   +  Q+ +K++D+Q    Q +  +KE + +   LE++ E       K E    +   
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 1142

Query: 745  SKEQALQDLQQ-------QRQLNTDLELRATELSKQLE----MEKEIVSSTR-------L 786
              E+  + L++       Q +LN   E    +L + LE      + +V++ R        
Sbjct: 1143 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVA 1202

Query: 787  DLQKKSEALESIKQKLTKQEEEKQI----LKQDFETLSQ-----------------ETKI 825
            +L ++ + L+ +KQKL K++ E ++    L    E++S+                 E + 
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262

Query: 826  QHEELN----------NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
            ++EE+           +R+QT   EL +   EKE+++++LS  K   ++ ++ LK    E
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322

Query: 876  FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
              K       A+      C  L+ Q + + E   + Q+ L K+    + A  + K E ++
Sbjct: 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA--NSEVAQWRTKYETDA 1380

Query: 936  MQ--EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
            +Q  E+L +A+  L Q  ++ ++    +N    S E+ K++++    +L + V +   L 
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440

Query: 994  NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
              L ++     + LA  K K    Q   E S +  + L ++ +  ++        L++V+
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500

Query: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
             +    ++++     QI    K I EL+ ++  +E + A  +  L+E   AL+  + +  
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKIL 1560

Query: 1114 LKEKELVNEKSKL--------AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK--- 1162
              + EL   KS++         EIE++K   ++ +  +   L + ++ S  E   LK   
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA-EVRSRNEAIRLKKKM 1619

Query: 1163 --DAKQLLIQQKLELQGKADSLK--AAVEQEKRNQQILKDQVKKEEEELKKE--FIEKEA 1216
              D  ++ IQ     +  A++LK   +V+ + ++ Q+  D   + +E+LK++   +E+ A
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRA 1679

Query: 1217 K-LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
              L +E++E    +++ E        ++   NE +  +  +  S      +LE     L+
Sbjct: 1680 NLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQ 1739

Query: 1276 GEIAVLEATVQNNQDE-RRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
             E+       +N +++ ++A+ +  +  E E++K Q     L+R   N    V++L
Sbjct: 1740 SEVEDASRDARNAEEKAKKAITDAAMMAE-ELKKEQDTSAHLERMKKNLEQTVKDL 1794



 Score =  179 bits (455), Expect = 1e-44
 Identities = 234/1069 (21%), Positives = 464/1069 (43%), Gaps = 166/1069 (15%)

Query: 58   KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
            K  +  H    D     E  +       + L Q+V+DL++SL++EK    +L++   K +
Sbjct: 998  KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE 1057

Query: 118  GLQQQEAKPDGLVTDSSAELQSLEQQLEE-AQTENFNIKQMKD----------LFEQKAA 166
            G  +       L  +S  +L++ +QQL+E  + ++F   Q++            F++K  
Sbjct: 1058 GDLK-------LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110

Query: 167  QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
            +L   I +++ + + ER+ R   E++ +    EL       ++L   L +  G+    + 
Sbjct: 1111 ELQARIEELEEEIEAERATRAKTEKQRSDYAREL-------EELSERLEEAGGVTSTQI- 1162

Query: 227  KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
                           L ++RE+E LK   + L+      EA ++ LR + A    E+   
Sbjct: 1163 --------------ELNKKREAEFLKLR-RDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207

Query: 287  VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
            +  LQ++K                 L+KE+   KLE   ++ S S +++  +    +  C
Sbjct: 1208 IDNLQRVKQK---------------LEKEKSEFKLE--IDDLSSSMESVSKSKANLEKIC 1250

Query: 347  QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
            + L+               +LSE     ++++  LSE+ T+   L+ E  +L +Q EEKE
Sbjct: 1251 RTLED--------------QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296

Query: 407  QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
                QL         +  E +RQL E +   K +  L+    +   +   DL      L 
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEEN---KAKNALA--HALQSSRHDCDL------LR 1345

Query: 467  EQLKEKVTNSTELQHQLDKTKQQ------HQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
            EQ +E+     ELQ  L K   +        E  A+Q+  T +L EA+  L Q L+   +
Sbjct: 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRLQDSEE 1403

Query: 521  KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK-NHTLQEQVTQ 579
            + + +    A L+K+K+    L+ E EDL   ++      A L++ Q   +  L E  T+
Sbjct: 1404 QVEAVNAKCASLEKTKQR---LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460

Query: 580  LTEKLKNQSESHKQAQE------NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
              E       S K+++        L +  +E    L   +    +LE  + +L  Q+ E+
Sbjct: 1461 CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520

Query: 634  KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
             + + +L+   K++ ++ L        ++AD+Q  L+ A+ AL+ ++ ++ +I  +L QV
Sbjct: 1521 GKTIHELE---KSRKQIEL--------EKADIQLALEEAEAALEHEEAKILRIQLELTQV 1569

Query: 694  TAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
             +++  K    ++ +  +++ K  Y  ++E     L+ +++    +++ +K   E  L +
Sbjct: 1570 KSEIDRK---IAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-RNEAIRLKKKMEGDLNE 1625

Query: 753  LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
            ++ Q    +    +A E  K L   +  +  T+L L       E +K++L   E    +L
Sbjct: 1626 IEIQL---SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLL 1682

Query: 813  KQDFETL-------SQETKIQHEEL---NNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
            + + E L        +  K+  +EL   N R+Q   T+   +   K+ L T+L  ++ ++
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742

Query: 863  SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
               S   +N++       +K K AI D     +ELK +     ++T    + +KK+LE+ 
Sbjct: 1743 EDASRDARNAE-------EKAKKAITDAAMMAEELKKE-----QDTSAHLERMKKNLEQT 1790

Query: 923  -KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE-QKKKQIEALQG 980
             K+  H+L        EQL      LK  +K+ Q+L+  I EL+   E ++KK  E+++G
Sbjct: 1791 VKDLQHRL-----DEAEQL-----ALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840

Query: 981  ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
                  L+K E   K   +LT  ++E   +++ +  LQ+  +K Q   K  +      + 
Sbjct: 1841 ------LRKYERRVK---ELTYQSEE---DRKNVLRLQDLVDKLQVKVKSYKRQAEEADE 1888

Query: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089
            +  A     +  + +L  A+E      +Q+       ++  +++  + +
Sbjct: 1889 QANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937



 Score =  129 bits (323), Expect = 3e-29
 Identities = 161/716 (22%), Positives = 338/716 (47%), Gaps = 92/716 (12%)

Query: 683  LNKITTQLDQVTAK--LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
            L    T+ +  T K   Q  ++  ++ E+  KE +EK ++L Q+  +L+ Q+   +A+S 
Sbjct: 841  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV---QAESE 897

Query: 741  EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
             +  ++E+  Q ++ + QL    E +  E++++ E E+EI +      +K  +    +K+
Sbjct: 898  NLLDAEERCDQLIKAKFQL----EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 953

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQH--EELNNRIQTTVTELQKVKMEKEALMTELSTV 858
             +   + E  + K + E  + E K+++  EEL+   +T    + K+  EK+AL       
Sbjct: 954  DI--DDLELTLAKVEKEKHATENKVKNLTEELSGLDET----IAKLTREKKALQEAHQQA 1007

Query: 859  KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
             D L    D + +                  L KT  +L+ Q++  +E++L+++K+L+  
Sbjct: 1008 LDDLQAEEDKVNS------------------LNKTKSKLEQQVE-DLESSLEQEKKLRVD 1048

Query: 919  LEKEKEASHQLKLELNSMQEQLIQAQNT-------LKQNEKEEQQLQGNINELKQSSEQK 971
            LE+ K    +L+ +L   QE ++  +N        LK+ + E  QLQ  + + +    Q 
Sbjct: 1049 LERNKR---KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF 1105

Query: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031
            +K+I+ LQ  ++  + ++ E E   + +  +   + A E E++S  +   E    T  Q+
Sbjct: 1106 QKKIKELQARIE-ELEEEIEAERATRAKTEKQRSDYARELEELS--ERLEEAGGVTSTQI 1162

Query: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS-----NRNQIGNQNKLIQELKTAKAT 1086
            + +   RE+E L  R+DL    E+ +L  E +++     + + +    + I  L+  K  
Sbjct: 1163 ELN-KKREAEFLKLRRDL----EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQK 1217

Query: 1087 LEQDSAKKEQQLQERCKALQDIQKEKSLKEK-------ELVNEKSK-------LAEIEEI 1132
            LE++ ++ + ++ +   +++ + K K+  EK       +L   + K       L+E+   
Sbjct: 1218 LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQ 1277

Query: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ------KLELQGKA-DSLKAA 1185
            K R + E  +L+ +L+    ESI  ++ L  +KQ   QQ      +LE + KA ++L  A
Sbjct: 1278 KSRLQTEAGELSRQLEEK--ESI--VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333

Query: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
            ++  + +  +L++Q + EE+E K E     +K +SE+ +      K+E +  + T ++  
Sbjct: 1334 LQSSRHDCDLLREQYE-EEQEGKAELQRALSKANSEVAQWRT---KYETDAIQRTEELEE 1389

Query: 1246 ----LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK 1301
                L + L   +++ ++   + + LEK    L+GE+  L   V+       AL ++   
Sbjct: 1390 AKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN 1449

Query: 1302 GEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1357
             +  + + +TK  E Q +L+ +    + L  E   L+  + +AL++      E +N
Sbjct: 1450 FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505



 Score =  103 bits (257), Expect = 1e-21
 Identities = 145/690 (21%), Positives = 295/690 (42%), Gaps = 91/690 (13%)

Query: 6    LQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGS----ADELFKHYE 61
            +QR+   + +Q S L + A  ++      ES     I  Q  +S  +     +EL +  E
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKES-----IVSQLSRSKQAFTQQTEELKRQLE 1321

Query: 62   AVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG-LQ 120
              + A N   H  +S+    R D  LLR++ +       EE+    EL++ L K    + 
Sbjct: 1322 EENKAKNALAHALQSS----RHDCDLLREQYE-------EEQEGKAELQRALSKANSEVA 1370

Query: 121  QQEAKPDGLVTDSSAELQSLEQQL------EEAQTENFNIKQMKDLFEQKAAQLATEIAD 174
            Q   K +      + EL+  +++L       E Q E  N K      E+   +L  E+ D
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS--LEKTKQRLQGEVED 1428

Query: 175  IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ 234
            +    +   SL  A ++K     + L +  T  ++ + EL     +++   L  EL +++
Sbjct: 1429 LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL--EASLKESRSLSTELFKLK 1486

Query: 235  TLMDNMTLERE---RESEKLKDECKKLQSQYASSEATISQLRS------------ELAKG 279
               +    + E   RE++ L+ E   L  Q A +  TI +L              +LA  
Sbjct: 1487 NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546

Query: 280  PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH-------------- 325
              E A+  +E + L+  + ELTQ    +   + +K+++  +L+  +              
Sbjct: 1547 EAEAALEHEEAKILRIQL-ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605

Query: 326  ----NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH-----------RIHVELSEK 370
                NE    KK ++  L++  ++ Q   +   A+ET  H           ++H++ + +
Sbjct: 1606 VRSRNEAIRLKKKMEGDLNE--IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663

Query: 371  GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK--LLETER 428
            G+  + LKE+L+ VE +   L+AE ++L+   E+ E+     + E+   + +  LL T+ 
Sbjct: 1664 GQ--EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721

Query: 429  QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
                    +  +++L ++ LM  + +V D        EE+ K+ +T++  +  +L K + 
Sbjct: 1722 T-----SLIHTKKKLETD-LMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775

Query: 489  QHQEQQALQQSTTAKLREAQNDLEQV--LRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
                 + ++++    +++ Q+ L++   L   G K Q IQ LE  +++ +  +   +K+ 
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ-IQKLETRIRELEFELEGEQKKN 1834

Query: 547  EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
             +    ++  E     L    E++     ++  L +KL+ + +S+K+  E   +Q     
Sbjct: 1835 TESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894

Query: 607  AHLRAAQDRVLSLETSVNELNSQLNESKEK 636
               R AQ  +   E   +   SQ+N+ + K
Sbjct: 1895 TKFRKAQHELEEAEERADIAESQVNKLRAK 1924


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  204 bits (518), Expect = 6e-52
 Identities = 265/1268 (20%), Positives = 545/1268 (42%), Gaps = 190/1268 (14%)

Query: 123  EAKPDGLVTDSSA----ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK 178
            + KP   +  SSA    E++SL ++L + + +N  +         K   +  E+   ++K
Sbjct: 213  QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAK 272

Query: 179  YDEERSLREAA------EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232
                 S ++ A      E+++  L  E++ +  V+++ + +L Q                
Sbjct: 273  VSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQS--------------- 317

Query: 233  VQTLMDNMTLERERESEKLKDECKKLQS---QYASSEATISQLRSELAKGPQEVA-VYVQ 288
                   M +E+E+  ++ K+EC KL+    +         + R+E     +E++  + Q
Sbjct: 318  -----QKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQ 372

Query: 289  ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348
              +K+   + ++  + + L  NL   E++  +L+E+        + ++  L Q   +   
Sbjct: 373  YKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNN 432

Query: 349  LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
             + +L         +  +L+E  ++  KL+   SE+E K + L+ +F  + + RE K + 
Sbjct: 433  GKEKLRIMAVKNSEVMAQLTESRQSILKLE---SELENKDEILRDKFSLMNENRELKVRV 489

Query: 409  GLQ------LQSEINQLHSKLLETERQLG------EAHGRLKEQRQLSSEKLMDKEQQ-- 454
              Q       Q EI     +L   E+ +       E  G      +       +KE +  
Sbjct: 490  AAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI 549

Query: 455  ---------VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
                     +++L++KL+  E ++++   N T   +QL ++     + Q   + ++ +  
Sbjct: 550  GCCEANKLVISELRIKLAIKEAEIQKLHANLTA--NQLSQSLITCNDSQESSKLSSLETE 607

Query: 506  EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
              +    QV   + D++Q   N +   ++ +     L    E+L  K+   E E + L +
Sbjct: 608  PVKLGGHQVAESVKDQNQHTMNKQYEKERQR-----LVTGIEELRTKLIQIEAENSDL-K 661

Query: 566  LQEKNHTLQEQVTQ--LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
            +   + T Q Q+ Q  L EK  N S+   +  +     +  +K  L        S+    
Sbjct: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKN 720

Query: 624  NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
             EL  +L E  EK+  L+  I  + E +  A   + A++  L+ H        ++ ++++
Sbjct: 721  AELEQELMEKNEKIRSLETNINTEHEKICLA--FEKAKKIHLEQH--------KEMEKQI 770

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE-V 742
             ++  QL++   + +++++  S L+  +   +    SL++   E +G++KK      E +
Sbjct: 771  ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830

Query: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
            KA + Q  ++  + RQL++ LE+   EL   L   +         L+KKSE +  ++++L
Sbjct: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890

Query: 803  T------KQEEEKQILKQDFETLSQETKIQHEEL--NNRIQTTVTELQKV--KMEKEALM 852
                   ++  E+ ++ Q   TL Q+ ++  +E   N  ++ T T+L+K   K+E+E L 
Sbjct: 891  KIKNHSLQETSEQNVILQ--HTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE-LQ 947

Query: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
             +  +  +KL K+ +  +++  E + + QK    +++L  T +++K ++    E   K +
Sbjct: 948  KQRESSAEKLRKMEEKCESAAHEADLKRQK----VIELTGTARQVKIEMDQYKEELSKME 1003

Query: 913  KE---LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
            KE   LK+  E +     QL + L+  + +L +  N +K+ EK +   +  + E  Q  E
Sbjct: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063

Query: 970  QKKKQIEALQGELKIAVLQKTELENKLQQ-----------------QLTQAAQELAAEKE 1012
              + +++   GELK  + Q  EL + LQ+                 +L +   E+  +K+
Sbjct: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123

Query: 1013 KI-----SVLQNNYEKSQETFKQLQSDFYGRES--------------------ELLATRQ 1047
            ++     ++ + N+E  Q   +    D   RE                     EL    +
Sbjct: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183

Query: 1048 DLKSVEEKLSLAQEDL-------ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
             ++S+ +KL  A+E L       + N  +I    K I+  +     +E    ++EQ +  
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243

Query: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160
            + K   D+ +E  L  +++ N  ++LAE    + + ++EI +L+ EL     E +K+++ 
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL-----EDMKQLSK 1298

Query: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK---EEEELKKEFIEKEAK 1217
             KDA    +         A+ L A+  +E   +  ++ ++KK   E E LK+ +      
Sbjct: 1299 EKDAHGNHL---------AEELGASKVREAHLEARMQAEIKKLSAEVESLKEAY------ 1343

Query: 1218 LHSEIKEKEVGMKKHEENEAKLTMQ-------ITALNENLGTVKKEWQSSQRRVSELEKQ 1270
             H E       M  H+EN AK  +        +  LNE L   K E + +Q  VS L +Q
Sbjct: 1344 -HME-------MISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQ 1395

Query: 1271 TDDLRGEI 1278
              D R E+
Sbjct: 1396 VQD-RNEV 1402



 Score =  194 bits (492), Expect = 7e-49
 Identities = 279/1229 (22%), Positives = 555/1229 (45%), Gaps = 150/1229 (12%)

Query: 69   DSGHGGESNLALKRDDVTLLRQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPD 127
            +S     +++ +  + +  L  EV      L+E E    +  K  +EK Q LQ+ + +  
Sbjct: 277  ESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECI 336

Query: 128  GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-ERSLR 186
             L  D   + +  ++   +     +N +++   F+Q   ++A ++  ++++ +  ER+L 
Sbjct: 337  KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLT 396

Query: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQ--------RPGIEDVAVLKKELVQVQTLMD 238
               E++  RL E      + ++ LK +L Q        +  +  +AV   E++   T   
Sbjct: 397  NC-EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESR 455

Query: 239  NMTLERERESEKLKDECKK----LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294
               L+ E E E  KDE  +    L ++    +  ++     L    QE+     EL+ L+
Sbjct: 456  QSILKLESELEN-KDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLE 514

Query: 295  SSVNELTQKNQTLT-ENLLKKEQ--DYTKLEEK------HNEESVSKKNIQATLHQKDLD 345
              +++L  K +    ++ L K Q   ++  E++       N+  +S+  I+  +  K+ +
Sbjct: 515  KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI--KEAE 572

Query: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV--ETKYQHLKAEFKQLQQQRE 403
             Q+L + L+A++ S   I    S++      L+ E  ++      + +K + +    ++ 
Sbjct: 573  IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632

Query: 404  EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKLMDKEQQVADLQL 460
            EKE+   +L + I +L +KL++ E +  +    +     Q QL  E+L++K    + L+ 
Sbjct: 633  EKERQ--RLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690

Query: 461  KLSR-------LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
            ++++       LE+QL+EK+   + +       K    EQ+ ++++   K+R  + ++  
Sbjct: 691  EMTKKCSQLLTLEKQLEEKIVAYSSIA-----AKNAELEQELMEKNE--KIRSLETNINT 743

Query: 514  VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE----K 569
               +I    +K + +   L++ KE    +E+    L  K Q  + +   ++ LQ+    K
Sbjct: 744  EHEKICLAFEKAKKIH--LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801

Query: 570  NHTLQEQVTQLTE---KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
             H L+     LTE   ++K ++    +A + L +QV E+   +R       +LE    EL
Sbjct: 802  QHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS---ALEICKEEL 858

Query: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT---AQNALQDKQQEL 683
               LN+ +    + + Q+K K+E +   +     +   LQ   +     Q+ LQ +QQ L
Sbjct: 859  VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918

Query: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
             + T +  ++       ++  S+LE  L++ +E      +K EE      K E+ + E  
Sbjct: 919  QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE------KCESAAHEAD 972

Query: 744  ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
              +++ ++     RQ+  +++    ELSK   MEKEI+   R D + K+  L  +   L 
Sbjct: 973  LKRQKVIELTGTARQVKIEMDQYKEELSK---MEKEIMHLKR-DGENKAMHLSQLDMILD 1028

Query: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
            + + E   L++    + +  K+QH        +T TEL +   ++E L TEL     +L 
Sbjct: 1029 QTKTE---LEKKTNAVKELEKLQH--------STETELTEALQKREVLETELQNAHGELK 1077

Query: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
                 L+    E     QK + ++ +   T K+L  +L           +E K  +E +K
Sbjct: 1078 STLRQLQ----ELRDVLQKAQLSLEEKYTTIKDLTAEL-----------RECKMEIEDKK 1122

Query: 924  EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK----KKQIEALQ 979
            +       EL  M + L +    LKQ   +   L   I E +   EQK    +  +E  +
Sbjct: 1123 Q-------ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175

Query: 980  GELKIAVLQKTELENKLQ---QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036
             ELK    Q   L +KLQ   +QL +    +   +++IS L+   E++Q+  K+++S   
Sbjct: 1176 LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMK 1235

Query: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE- 1095
             +E + +AT+      +E + L QE L   R Q+ N +      + A+A  +Q  A++E 
Sbjct: 1236 EQE-QYIATQ-----YKEAIDLGQE-LRLTREQVQNSH-----TELAEARHQQVQAQREI 1283

Query: 1096 QQLQERCKALQDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITKLNEELKSHKLE 1153
            ++L    + ++ + KEK      L  E   SK+ E   ++ R + EI KL+ E     +E
Sbjct: 1284 ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE-AHLEARMQAEIKKLSAE-----VE 1337

Query: 1154 SIKEITNLKDAKQLLIQQKLELQGK--ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1211
            S+KE  ++    +++  Q+   + K  ADS K++V+Q       L +Q++K + EL +E 
Sbjct: 1338 SLKEAYHM----EMISHQENHAKWKISADSQKSSVQQ-------LNEQLEKAKLEL-EEA 1385

Query: 1212 IEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
             +  + LH +++++   ++    NEA LT
Sbjct: 1386 QDTVSNLHQQVQDRNEVIE--AANEALLT 1412



 Score =  179 bits (454), Expect = 2e-44
 Identities = 231/1149 (20%), Positives = 504/1149 (43%), Gaps = 134/1149 (11%)

Query: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
            QE++ L+  +N+L Q+N  L   + +     TK E  H E + S+  +        L+  
Sbjct: 229  QEIKSLREKLNKLRQQNACL---VTQNHSLMTKFESIHFELTQSRAKVSM------LESA 279

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
            Q Q+   AS   L    + L  +  A  K+   L E E K +  +    + +Q  +E ++
Sbjct: 280  QQQA---ASVPILEEQIINLEAEVSAQDKV---LREAENKLEQSQKMVIEKEQSLQESKE 333

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
              ++L+ ++ +   +    ERQ  EA    +E     S+     +++VA+   K+   EE
Sbjct: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL----SKAFQQYKKKVAEKLEKVQAEEE 389

Query: 468  QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
             L+  +TN  +   +L +    ++ +  + +    +L+E  N+ ++ LR +  K+ ++  
Sbjct: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM- 448

Query: 528  LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL--- 584
              A L +S+++I  LE E E+   K +    + +++N+    N  L+ +V    E+L   
Sbjct: 449  --AQLTESRQSILKLESELEN---KDEILRDKFSLMNE----NRELKVRVAAQNERLDLC 499

Query: 585  KNQSESHKQAQENLHDQVQEQ---------KAHLRAAQDRVLSLETSVNELNSQLNESKE 635
            + + ES +    +L   + +          K++L   Q  + S     +        +K 
Sbjct: 500  QQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQ--MSSFSNKEDRCIGCCEANKL 557

Query: 636  KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ---ELNKITTQLDQ 692
             +S+L I++  K   +    A  TA +  L   L T  ++ +  +    E   +     Q
Sbjct: 558  VISELRIKLAIKEAEIQKLHANLTANQ--LSQSLITCNDSQESSKLSSLETEPVKLGGHQ 615

Query: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS------- 745
            V   ++D+ +H        K+Y+++   L    EEL  ++ ++EA++ ++K +       
Sbjct: 616  VAESVKDQNQHTMN-----KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQ 670

Query: 746  ----KEQALQDLQQQRQLNTDLELRATEL-SKQLEMEKEIVSSTRL---------DLQKK 791
                +E+ L+      +L +++  + ++L + + ++E++IV+ + +         +L +K
Sbjct: 671  FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730

Query: 792  SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM---EK 848
            +E + S++  +  + E+  +  +  + +  E   QH+E+  +I+    +L+K      E+
Sbjct: 731  NEKIRSLETNINTEHEKICLAFEKAKKIHLE---QHKEMEKQIERLEAQLEKKDQQFKEQ 787

Query: 849  EALMTELST----VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL-----EKTCK--EL 897
            E  M+ L       +  L  +   L  SK E +KEN K   A+  L     E+T K  +L
Sbjct: 788  EKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQL 847

Query: 898  KHQLQVQME-----------NTLKEQKELKKSLEKEKEASHQLKLELNSMQE---QLIQA 943
               L++  E           N  K +K+LKK  E+      +LK++ +S+QE   Q +  
Sbjct: 848  DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907

Query: 944  QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
            Q+TL+Q ++  QQ      EL+ +  + +KQ+  L+ EL+       E   K++++   A
Sbjct: 908  QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967

Query: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD-------LKSVEEKL 1056
            A E   +++K+  L     + +    Q + +    E E++  ++D       L  ++  L
Sbjct: 968  AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027

Query: 1057 SLAQEDLISNRNQIGNQNKL-------IQELKTAKATLEQDSAKKEQQLQERCKALQD-- 1107
               + +L    N +    KL       + E    +  LE +      +L+   + LQ+  
Sbjct: 1028 DQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELR 1087

Query: 1108 --IQKEKSLKEKELVNEKSKLAEIEEIKCR---QEKEITKLNEELKSHKLESIKEITNLK 1162
              +QK +   E++    K   AE+ E K     +++E+ ++++ LK    E  +    + 
Sbjct: 1088 DVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT 1147

Query: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
                 + + + E++ K   L+  +E+ +   +    Q++   ++L+            ++
Sbjct: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQ--------NAKEQL 1199

Query: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
            +EKE  M ++E+  ++L  +I    + +  ++   +  ++ ++   K+  DL  E+ +  
Sbjct: 1200 REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTR 1259

Query: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1342
              VQN+  E      + ++ + EIE+L +++ ++++      A    L  E  + +++  
Sbjct: 1260 EQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREA 1319

Query: 1343 QALNRKWAE 1351
                R  AE
Sbjct: 1320 HLEARMQAE 1328



 Score =  149 bits (377), Expect = 1e-35
 Identities = 199/913 (21%), Positives = 408/913 (44%), Gaps = 146/913 (15%)

Query: 522  DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT 581
            DQ+I++L   L K ++  + L  +   L  K ++   E   L Q + K          + 
Sbjct: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFE---LTQSRAK--------VSML 276

Query: 582  EKLKNQSESHKQAQE---NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
            E  + Q+ S    +E   NL  +V  Q   LR A++++   +  V E    L ESKE+  
Sbjct: 277  ESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC- 335

Query: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNH--LDTAQNALQDKQQELNKITTQLDQVTAK 696
                 IK K +LL   E  K  +RA+ Q +  L  A+   +  QQ   K+  +L++V A+
Sbjct: 336  -----IKLKVDLL---EQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAE 387

Query: 697  LQ--------------DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
             +                QE C   +S L+  KEK   L+++    + +++ +   + EV
Sbjct: 388  EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447

Query: 743  KA-----------------SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
             A                 +K++ L+D       N +L++R    +++L++ ++ + S+R
Sbjct: 448  MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507

Query: 786  LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE----------TKIQHEELNNRIQ 835
            ++L+   + +  +  K      +  + K    + S +           K+   EL  ++ 
Sbjct: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567

Query: 836  TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK-SEFEKENQKGKAAILDLEKTC 894
                E+QK+     A     + +   L   +DS ++SK S  E E  K     L   +  
Sbjct: 568  IKEAEIQKLHANLTA-----NQLSQSLITCNDSQESSKLSSLETEPVK-----LGGHQVA 617

Query: 895  KELKHQLQVQMENTL-KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
            + +K Q Q  M     KE++ L   +E+ +    Q++ E + ++  +    +  +  ++E
Sbjct: 618  ESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEE 677

Query: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
              +   N ++L+    +K  Q+  L+ +L+    +K    + +  +  +  QEL  + EK
Sbjct: 678  LLEKASNSSKLESEMTKKCSQLLTLEKQLE----EKIVAYSSIAAKNAELEQELMEKNEK 733

Query: 1014 ISVLQNN-----------YEKSQ----ETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
            I  L+ N           +EK++    E  K+++      E++L    Q  K  E+ +S+
Sbjct: 734  IRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSM 793

Query: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118
             Q+D+I  ++ + + ++L+ E   +K  +++++ KK++ L    KALQ+   E+++K ++
Sbjct: 794  LQQDIICKQHHLESLDRLLTE---SKGEMKKENMKKDEAL----KALQNQVSEETIKVRQ 846

Query: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178
            L        EI    C++E  +  LN+ L+ +K +  K++   K ++++   QK EL+ K
Sbjct: 847  L----DSALEI----CKEEL-VLHLNQ-LEGNKEKFEKQLK--KKSEEVYCLQK-ELKIK 893

Query: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKK--EFIEKEAKLHSEIKEKEVGMKKHEENE 1236
              SL+   EQ    Q  L+ Q +  ++E  +  E  + + KL  ++ + E  ++K  E+ 
Sbjct: 894  NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953

Query: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSEL-------EKQTDDLRGEIAVLEATVQNNQ 1289
            A+   ++  + E   +   E    +++V EL       + + D  + E++ +E  + +  
Sbjct: 954  AE---KLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH-- 1008

Query: 1290 DERRALLERCLKGEGEIEKLQTKVLEL-----QRKLDNTTAAVQELGRENQSLQIKHTQA 1344
                      LK +GE + +    L++     + +L+  T AV+EL +   S + + T+A
Sbjct: 1009 ----------LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058

Query: 1345 LNRKWAEDNEVQN 1357
            L ++   + E+QN
Sbjct: 1059 LQKREVLETELQN 1071



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 123/579 (21%), Positives = 248/579 (42%), Gaps = 91/579 (15%)

Query: 47   MKSLGSADELFKHYEAVH-DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY 105
            ++ L SA E+ K    +H +    +    E  L  K ++V  L++E++    SL+E    
Sbjct: 844  VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903

Query: 106  SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS----LEQQLE---EAQTENFNIKQMK 158
            +  L+  L++ Q + QQE   +G + D+  +L+     LEQ+L+   E+  E     + K
Sbjct: 904  NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963

Query: 159  --------DLFEQKAAQLATEIADIK---SKYDEERS--------LREAAEQKVTRLTE- 198
                    DL  QK  +L      +K    +Y EE S        L+   E K   L++ 
Sbjct: 964  CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023

Query: 199  ---------ELNKEATVIQDLKTELLQRPGIEDV--AVLKKELVQVQTLMDNMTLERE-R 246
                     EL K+   +++L  E LQ     ++  A+ K+E+++ +    +  L+   R
Sbjct: 1024 DMILDQTKTELEKKTNAVKEL--EKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            + ++L+D  +K Q        TI  L +EL +   E+    QEL ++  ++ E   +N  
Sbjct: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKE---RNWE 1138

Query: 307  LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
            L +   +       + E   E       ++ TL + +L+ ++   ++ +    L     +
Sbjct: 1139 LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198

Query: 367  LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH-----------GLQLQ-- 413
            L EK     + ++E+S+++ + +  +   K+++   +E+EQ+           G +L+  
Sbjct: 1199 LREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLT 1258

Query: 414  -SEINQLHSKLLET-------ERQLGEAHGRLKEQRQLSSEK----------LMDKEQQV 455
              ++   H++L E        +R++      L++ +QLS EK          L   + + 
Sbjct: 1259 REQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318

Query: 456  ADLQLKLSRLEEQLKEKVTNSTELQH-------------QLDKTKQQHQEQQALQQSTTA 502
            A L+ ++    ++L  +V +  E  H             ++    Q+   QQ  +Q   A
Sbjct: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378

Query: 503  KLR--EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
            KL   EAQ+ +  + +Q+ D+++ I+     L    EN+
Sbjct: 1379 KLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 83/364 (22%), Positives = 162/364 (44%), Gaps = 59/364 (16%)

Query: 1033 SDFYGRESE---LLAT----RQDLKSVEEKLSLAQEDLIS-----NRNQIGNQN---KLI 1077
            SD+Y +++E   LLA     R +LK  E  L    E+L S     N +   N +   KLI
Sbjct: 124  SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLI 183

Query: 1078 QELKTAKATL---------------EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
             +++ +   L                 D  KK +       A  D Q+ KSL+EK     
Sbjct: 184  LDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVD-QEIKSLREK----- 237

Query: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ------LLIQQKLELQ 1176
             +KL +       Q   +    E +     +S  +++ L+ A+Q      +L +Q + L+
Sbjct: 238  LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLE 297

Query: 1177 GKADSL-KAAVEQEKRNQQILKDQVKKEE--EELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
             +  +  K   E E + +Q  K  ++KE+  +E K+E I+ +  L  + K+ +    + +
Sbjct: 298  AEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGK--RAERQ 355

Query: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
             NEA           N   + K +Q  +++V+E   + + ++ E  +LE  + N + E +
Sbjct: 356  RNEALY---------NAEELSKAFQQYKKKVAE---KLEKVQAEEEILERNLTNCEKENK 403

Query: 1294 ALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDN 1353
             L ERC   + E+E L+ K+ +L+ + +N    ++ +  +N  +  + T++       ++
Sbjct: 404  RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463

Query: 1354 EVQN 1357
            E++N
Sbjct: 464  ELEN 467


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  201 bits (511), Expect = 4e-51
 Identities = 298/1407 (21%), Positives = 624/1407 (44%), Gaps = 172/1407 (12%)

Query: 82   RDDVTLLRQEVQDLQASLKEEK-WYSEE--LKKELEKYQGLQQQEAKPDGLVTDSSAELQ 138
            R++    R+E QD     +EEK W   E  L+KE EK   LQ++E +    + +   +L+
Sbjct: 223  REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK---LQEEEPQRQRELQEEEEQLR 279

Query: 139  SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
             LE+Q  E + E    +Q +    ++      +  + + + +E R  +E  EQ+  R  +
Sbjct: 280  KLERQ--ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337

Query: 199  ELNKEATV--IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECK 256
            +L +E      Q L+ E  +    + +   ++E  + Q L     L RE   ++L+ E +
Sbjct: 338  QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE---QQLRREQQ 394

Query: 257  KLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
              + Q    E    QLR E     ++     Q+L++ +       +  Q   E  LK+EQ
Sbjct: 395  LRREQQLRRE---QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 317  ----DYTKLEEKHNEESVSKKNIQATLHQKD--------LDCQQLQSRLSASETSLHRIH 364
                D+ K EE+       ++  Q    Q++        L+ ++ + +    E  L R  
Sbjct: 452  EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511

Query: 365  VELSEKGEATQKLKEELSEVETKYQHLKAE--------FKQLQQQREEKEQHGLQLQSEI 416
             E  E+    Q+ +E L +     Q L+ E         K+ +++R E+E+   +L+ E 
Sbjct: 512  EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571

Query: 417  NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE-------QQVADLQLKLSRLEEQL 469
             +   +LL+ E +      RLK +++   E+ + +E       ++  + +LK    EE+ 
Sbjct: 572  EERRDQLLKREEE--RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 470  KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL- 528
            ++++  S E   Q ++ +QQ + +Q  ++    K  E +  LEQ L++  +++++ Q L 
Sbjct: 630  RQQLLKSEE---QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 529  EALLQKSKENI-SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
            E   ++++E I S + K +  L ++  A + +     + QE     QEQ     ++ + +
Sbjct: 687  EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE---EKRRRRE 743

Query: 588  SESHKQAQENLHDQVQEQKAH-------------------------LRAAQDRVLSLETS 622
            SE   Q +E  H Q QE++                           LR  ++R L  E  
Sbjct: 744  SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
                   L E +EK  Q   Q + + + L   E  +  QR +    L   ++ LQ+ Q+ 
Sbjct: 804  QQREQRFLPEEEEK-EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862

Query: 683  LNKITTQLDQ----------------------VTAKLQDKQEHCSQLESHL-KEYKEKYL 719
                  + DQ                      +  +L+ +Q+   + E  L +E +EK  
Sbjct: 863  RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922

Query: 720  SLEQ-----KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
              EQ     + E+L+ + ++L  +  E +  +E+  Q  + ++    + +L   E  K+ 
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 775  EMEKEIVSSTRLDLQKKSE-ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
              E+E       +LQ++ E  L   ++K  +QE E+Q  K+D     +E  ++ E    R
Sbjct: 983  RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042

Query: 834  IQ---TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE----NQKGKAA 886
            +Q       E ++++ E+E L+ E    + +        K  + + E+E     +  K  
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102

Query: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ-- 944
              + E+ C+E + +LQ + E  L+E++E ++  E E++  ++ + E+   +EQL++ +  
Sbjct: 1103 RQERERQCRE-EEELQQEEEQLLREEREKRRRQELERQ--YREEEEVQQEEEQLLREEPE 1159

Query: 945  ----NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
                  L++  +EE++LQ    +L +  ++K++Q E  +   +   LQ+ + + + + + 
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQ-ERERQYREEEELQRQKRKQRYRDED 1218

Query: 1001 TQAAQELAAEKEKISVLQNN--YEKSQET--FKQLQSDFYGRESELLATRQDLKSVEEKL 1056
             ++  +   E EK + +++N  Y K +E   F+QL       E   L  RQ  + ++  L
Sbjct: 1219 QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL-------EDSQLRDRQSQQDLQHLL 1271

Query: 1057 SLAQE-DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
               QE D    R +   +++   E +  +   ++++ +++++ QE  + L++ ++EK  +
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 1116 ---EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK-------------EIT 1159
               +++   E+  L E EE   R+++   K  EE   H+ +  K             E  
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391

Query: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE------ELKKEFIE 1213
             LK+ +QL  Q++ E Q + D  +   E+E++  +  +D+  +EEE      E +++F+E
Sbjct: 1392 FLKEEQQLRCQER-EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450

Query: 1214 KEAKL----HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
            +E +L    H + +E+E  +++ EE +     +     E    ++++ +  + R  EL  
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510

Query: 1270 QTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329
            Q  + +     LE   Q ++ +R+    + L+ E ++ + Q +  + ++  D      ++
Sbjct: 1511 QEPERK----FLEEEQQLHRQQRQ---RKFLQEEQQLRR-QERGQQRRQDRDRKFREEEQ 1562

Query: 1330 LGRENQSLQIKHTQALNRKWAEDNEVQ 1356
            L +E +  Q+   +   +   E+ +V+
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVR 1589



 Score =  187 bits (476), Expect = 5e-47
 Identities = 278/1302 (21%), Positives = 597/1302 (45%), Gaps = 160/1302 (12%)

Query: 89   RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ 148
            +QE ++ Q   ++E+   + LK++ E+ + LQQ+      L  +     + L ++ EE +
Sbjct: 499  QQERREQQLRREQEERREQRLKRQ-EEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557

Query: 149  TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208
             E       ++  EQ+  +   E  D   K +EER  +    ++  RL + L +      
Sbjct: 558  LE-------QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR------ 604

Query: 209  DLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEAT 268
                        E+V  L++E  + Q       L+RE   E+ + +  K + Q    E  
Sbjct: 605  ------------EEVERLEQEERREQ------RLKREEPEEERRQQLLKSEEQ---EERR 643

Query: 269  ISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK--HN 326
              QLR E  +         +  Q+LK       ++ +   E  LK+E +  + E++    
Sbjct: 644  QQQLRREQQE---------RREQRLK------REEEEERLEQRLKREHEEERREQELAEE 688

Query: 327  EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH-RIHVELSEKGEATQKLKEELSEVE 385
            E+  +++ I++ + +      QL+S   A ++ ++ R   +  ++    Q+ K    E E
Sbjct: 689  EQEQARERIKSRIPKWQ---WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745

Query: 386  TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ--RQL 443
             ++Q  +   +Q QQ+ E++     Q Q+E      +  E  RQ   A   L+EQ  RQL
Sbjct: 746  LQWQEEERAHRQ-QQEEEQRRDFTWQWQAE------EKSERGRQRLSARPPLREQRERQL 798

Query: 444  SSEKLMDKEQQV--ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK--QQHQEQQALQQS 499
             +E+   +EQ+    + + +  R + + +EK     E + QL + +  QQ QE++   Q 
Sbjct: 799  RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858

Query: 500  TTAKLREAQNDLEQVLRQIGDKDQK-----IQNLEALLQKSKENISLLEKEREDLYAKIQ 554
               + R  +   +Q  R   ++++K     +    AL ++ ++   LL++E E+L    Q
Sbjct: 859  DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL----Q 914

Query: 555  AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
              E E     Q QE+ +  +EQ+ Q  E+L  +    ++ QE      +++K  L+  ++
Sbjct: 915  REEREKR-RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK--LQQKEE 971

Query: 615  RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
            ++L       E   +  + +EK  + + +++ + E LL  E  K  +R + +        
Sbjct: 972  QLLG-----EEPEKRRRQEREKKYREEEELQQEEEQLLREEREK-RRRQEWERQYRKKDE 1025

Query: 675  ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT---EELEGQ 731
              Q+++Q L +     ++   +LQ+++    + E  L++ +E+ L  E++T   +ELE Q
Sbjct: 1026 LQQEEEQLLRE-----EREKRRLQERERQYRE-EEELQQEEEQLLGEERETRRRQELERQ 1079

Query: 732  IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
             +K E    E++  +EQ L++  ++R+   + E +  E  ++L+ E+E +     + +++
Sbjct: 1080 YRKEE----ELQQEEEQLLREEPEKRR-RQERERQCRE-EEELQQEEEQLLREEREKRRR 1133

Query: 792  SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
             E     +++   Q+EE+Q+L+++ E      K + +EL  + +    E ++++ E+E L
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPE------KRRRQELERQYR----EEEELQQEEEQL 1183

Query: 852  MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
            + E     ++  +  +  +  + E E + QK K    D E    +LK Q + + EN +++
Sbjct: 1184 LRE-----EQEKRRQERERQYREEEELQRQKRKQRYRD-EDQRSDLKWQWEPEKENAVRD 1237

Query: 912  QKELKKSLEKE---KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
             K   K  E E   +    QL+   +    Q +  +   +  E+E ++ Q       +  
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297

Query: 969  E-QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
            + ++++Q EA + + K    ++   E + +++  Q       E+E++  LQ   E+ ++ 
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL--LQ---EREEQP 1352

Query: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
             ++ + D   RE EL    Q  K +EE+  L +++    R  +  + +L    +  +  L
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE--RERKFLKEEQQL--RCQEREQQL 1408

Query: 1088 EQDSAKK----EQQL--QERCKALQDIQKE--KSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
             QD  +K    EQQL  QER +  ++ +++  +  +E++ + E+ +L +    K R+E++
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQK------LELQGKADSLKAAVEQEKRNQ 1193
            + +  EE + H+ E  ++   L++ +QL  Q++       EL+ +    K   E+++ ++
Sbjct: 1469 LLQEREEQQLHRQERDRKF--LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253
            Q  + +  +EE++L+++   ++ +   + K +E    + E  E +L+ Q       L   
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586

Query: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKV 1313
            K   Q  +R+  E E+Q     G+  + +   +  +++ + L ER        E+ Q   
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--------EEQQLHR 1638

Query: 1314 LELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
             E  RK         +L R+ +  Q++H +  +RK+ E+ ++
Sbjct: 1639 QERDRKF---LEEEPQLRRQEREQQLRHDR--DRKFREEEQL 1675



 Score =  186 bits (471), Expect = 2e-46
 Identities = 254/1257 (20%), Positives = 553/1257 (43%), Gaps = 129/1257 (10%)

Query: 96   QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155
            +A  ++ K YS   K+E ++ +  Q+++ +          E ++  QQ EE Q  +F  +
Sbjct: 711  EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770

Query: 156  QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL- 214
               +   ++  Q  +    ++ + + +    E  +++   L EE  KE    Q  + E  
Sbjct: 771  WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830

Query: 215  LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK-----------LKDECKKLQSQYA 263
            LQ    E+    ++   Q+Q   D +  ++ER   +           L++E K+ +    
Sbjct: 831  LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890

Query: 264  SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
            +  A   QLR E  +  QE    +Q  ++ K    E  Q+ Q   E  L++E++    EE
Sbjct: 891  AKPALQEQLRKE-QQLLQEEEEELQREEREKRRRQE--QERQYREEEQLQQEEEQLLREE 947

Query: 324  KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
            +       ++      ++KD   QQ + +L   E    R   E  +K    ++L++E  +
Sbjct: 948  REKRRRQERER----QYRKDKKLQQKEEQLLGEEPEKRR-RQEREKKYREEEELQQEEEQ 1002

Query: 384  V--ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
            +  E + +  + E+++  ++++E +Q   QL  E  +   +L E ERQ  E     +E+ 
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR-RLQERERQYREEEELQQEEE 1061

Query: 442  QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
            QL  E+   + +Q  + Q +     +Q +E++      + +  + ++Q +E++ LQQ   
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121

Query: 502  AKLREAQNDL--EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559
              LRE +     +++ RQ  ++++  Q  E LL++  E     E ER+    + +  + E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ-YREEEELQQEE 1180

Query: 560  TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV--QEQKAHLRAAQDRVL 617
              +L + QEK    +E+  +  E+L+ Q    +   E+    +  Q +     A +D  +
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240

Query: 618  SLETSVNELNSQLNES--KEKVSQLDIQ--IKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
              +   NE   QL +S  +++ SQ D+Q  +  + E     E  +  QR     H    +
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR---DRHFPEEE 1297

Query: 674  NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
               +++Q+E            AK +D+           K  +EK L  E++ E      K
Sbjct: 1298 QLEREEQKE------------AKRRDR-----------KSQEEKQLLREEREE------K 1328

Query: 734  KLEADSLEVKASKEQALQDLQQQ--RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
            +   ++      +EQ LQ+ ++Q  R+   D + R  EL  Q +  K +    RL  Q++
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388

Query: 792  SEALESIKQKLTKQEEEKQILK-QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
                   +Q+L  QE E+Q+ + +D +   +E ++  +E + + +    ++++ + E++ 
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 851  LMTELSTVKDKLSKV--SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
            L  E    +++  K    + L   + E +   Q+     L+ E+  +  +   + + E  
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR-EQE 1507

Query: 909  LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
            L+ Q+  +K LE+E++   Q +      Q + +Q +  L++ E+ +Q+ Q    + ++  
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQR------QRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561

Query: 969  ----EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
                E++++Q+   + + K  + ++     + +++  +  Q+L  ++ +  + Q    K 
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621

Query: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED----LISNRNQ-IGNQNKLIQE 1079
            +E  + LQ      E +L    +D K +EE+  L +++    L  +R++    + +L+QE
Sbjct: 1622 REDEQLLQER---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678

Query: 1080 LKTAKATLEQDSAK---KEQQLQERCKALQDIQKEKSLKEKEL---VNEKSKLAE----- 1128
             +  +   ++   K   +EQQL+ + +  + +Q+E+ L+ +EL     E+ +L +     
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738

Query: 1129 -----------IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG 1177
                       +EE + R E+E  +L  + +  K    +++   ++ +QL  Q+      
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798

Query: 1178 KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSE---------------- 1221
            + + L+   E+++   Q    + + EEE+L+ E  E+E +L  E                
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE--EQEQRLRQERDRQYRAEEQFATQEK 1856

Query: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
             + +E  + + EE + +   +     E++   +KE +   R+V E++ Q     G +
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKE-EQRHRQVGEIKSQEGKGHGRL 1912



 Score =  183 bits (465), Expect = 9e-46
 Identities = 246/1264 (19%), Positives = 563/1264 (44%), Gaps = 105/1264 (8%)

Query: 107  EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
            EEL ++ +++Q  +++ A+ + L    S +    E+  +E Q     + +++    ++  
Sbjct: 171  EELWRQRQEWQEREERRAEEEQL---QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227

Query: 167  QLATEIADIKSKYDEERSLRE---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223
            Q   E  D   + +EE+  R+      ++  +L EE  +    +Q+ + +L +    E  
Sbjct: 228  QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287

Query: 224  AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA---SSEATISQLRSELAKGP 280
               ++E  Q Q L     L R++E E+ + + ++ + Q       E    QLR E  +  
Sbjct: 288  RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347

Query: 281  QEVAVYVQEL----QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQ 336
            ++     QE     Q+L+    E  ++ Q   E  L++EQ   + ++   E+ + ++  Q
Sbjct: 348  EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ-Q 406

Query: 337  ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK 396
                Q+    QQL+             H +  E+    Q+LK E  E   +   LK E +
Sbjct: 407  LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE---RRDWLKREEE 463

Query: 397  -QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV 455
             +  +Q   K+Q     + E  +   KL E ER         +EQ++   ++L  ++++ 
Sbjct: 464  TERHEQERRKQQLKRDQEEERRERWLKLEEEER---------REQQERREQQLRREQEER 514

Query: 456  ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515
             + +LK    EE+L++++ +  +L+ +     Q+ + +Q L+       RE +  LEQ  
Sbjct: 515  REQRLKRQEEEERLQQRLRSEQQLRRE-----QEERREQLLK-------REEEKRLEQER 562

Query: 516  RQIGDKDQKIQNLEALLQKSKENIS--LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
            R+   K ++ +  + LL++ +E     L  ++ E L  +++  E E     + +E+    
Sbjct: 563  REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622

Query: 574  QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
            +E   +  ++L    E  ++ Q+ L  + QE++      ++    LE  +   + +    
Sbjct: 623  EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682

Query: 634  KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
            +E   +   Q + + +  +     +    AD +     ++   Q+ Q+   +   +  + 
Sbjct: 683  QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742

Query: 694  TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
             ++LQ ++E  +  +   +E +  +    Q  E+ E   ++L A            L++ 
Sbjct: 743  ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA---------RPPLRE- 792

Query: 754  QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813
            Q++RQL  +   +  +     E EKE     R + +K+ + LE  +Q   ++ E  Q L+
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ--LQRRERAQQLQ 850

Query: 814  QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873
            ++ + L ++ + +  +   R Q    +L++ +  +   +     ++++L K    L+  +
Sbjct: 851  EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910

Query: 874  SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
             E ++E ++ K    + E+  +E + QLQ + E  L+E++E ++  E+E++     KL+ 
Sbjct: 911  EELQRE-EREKRRRQEQERQYRE-EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ- 967

Query: 934  NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
                    Q +  L   E E+++ Q    + ++  E ++++ + L+ E +    Q+ E +
Sbjct: 968  --------QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019

Query: 994  NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
             + + +L Q  ++L  E+ +   LQ    + +E                    ++L+  E
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYRE-------------------EEELQQEE 1060

Query: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL--EQDSAKKEQQLQERCKALQDIQKE 1111
            E+L L +E     R ++  Q +  +EL+  +  L  E+   ++ Q+ + +C+  +++Q+E
Sbjct: 1061 EQL-LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119

Query: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
            +    +E   EK +  E+E  + R+E+E+ +  E+L   + E  +     +   +   ++
Sbjct: 1120 EEQLLRE-EREKRRRQELER-QYREEEEVQQEEEQLLREEPEKRR-----RQELERQYRE 1172

Query: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKK 1231
            + ELQ + + L    EQEKR Q+  +++  +EEEEL+++  +++ +   E +  ++  + 
Sbjct: 1173 EEELQQEEEQL-LREEQEKRRQE--RERQYREEEELQRQ--KRKQRYRDEDQRSDLKWQW 1227

Query: 1232 HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
              E E  +               ++ + SQ R  + ++    L G     E   ++ + E
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG-----EQQERDREQE 1282

Query: 1292 RRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAE 1351
            RR   +R  +   E E+L+ +  +  ++ D  +   ++L RE +  + +  Q  +RK+ E
Sbjct: 1283 RRRWQQRD-RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE-EKRRRQETDRKFRE 1340

Query: 1352 DNEV 1355
            + ++
Sbjct: 1341 EEQL 1344



 Score =  182 bits (463), Expect = 2e-45
 Identities = 295/1349 (21%), Positives = 603/1349 (44%), Gaps = 190/1349 (14%)

Query: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
            LKR++   L QE ++ +   ++E+   + LK+E E+ Q   ++E +          E++ 
Sbjct: 550  LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609

Query: 140  LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199
            LEQ  EE + +    ++ +   E++  QL      +KS+  EER  ++   ++  R  + 
Sbjct: 610  LEQ--EERREQRLKREEPE---EERRQQL------LKSEEQEERRQQQLRREQQERREQR 658

Query: 200  LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259
            L +E     + +  L QR        LK+E  + +   +    E+E+  E++K    K Q
Sbjct: 659  LKRE-----EEEERLEQR--------LKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705

Query: 260  SQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYT 319
             Q   SEA   Q  S++   P++     QE Q+ +    E  ++ ++        E  + 
Sbjct: 706  WQ-LESEADARQ--SKVYSRPRK-----QEGQRRRQEQEEKRRRRES--------ELQWQ 749

Query: 320  KLEEKHNEESVSKKNIQATLH-QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
            + E  H ++   ++    T   Q +   ++ + RLSA           L E+ E  Q   
Sbjct: 750  EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA--------RPPLREQRE-RQLRA 800

Query: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438
            EE  + E ++   + E +Q ++QR E+E+  LQ   E  QL  +  E  +QL E    L+
Sbjct: 801  EERQQREQRFLPEEEEKEQRRRQRREREKE-LQFLEEEEQLQRR--ERAQQLQEEEDGLQ 857

Query: 439  E--QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK---VTNSTELQHQLDKTKQ-QHQE 492
            E  +R+ S E+  D++ +         +LEE+ K +   +     LQ QL K +Q   +E
Sbjct: 858  EDQERRRSQEQRRDQKWR--------WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909

Query: 493  QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAK 552
            ++ LQ+    K R  + +     RQ  +++Q  Q  E LL++ +E     E+ER+  Y K
Sbjct: 910  EEELQREEREKRRRQEQE-----RQYREEEQLQQEEEQLLREEREKRRRQERERQ--YRK 962

Query: 553  IQ---------AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
             +          GE       Q +EK +  +E++ Q  E+L  +    ++ QE   ++  
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE--WERQY 1020

Query: 604  EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
             +K  L+  ++++L  E     L     + +E+  + + +++ + E LL  E  +T +R 
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRL-----QERERQYREEEELQQEEEQLL-GEERETRRRQ 1074

Query: 664  DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE- 722
            +L+      +   Q+++Q L +     +    + Q+++  C + E  L++ +E+ L  E 
Sbjct: 1075 ELERQYRKEEELQQEEEQLLRE-----EPEKRRRQERERQCRE-EEELQQEEEQLLREER 1128

Query: 723  --QKTEELEGQIKKLEADSLEVKASKEQAL---------QDLQQQRQLNTDLE------L 765
              ++ +ELE Q ++ E    EV+  +EQ L         Q+L++Q +   +L+      L
Sbjct: 1129 EKRRRQELERQYREEE----EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184

Query: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT---KQEEEKQILKQDFETL--- 819
            R  +  ++ E E++      L  QK+ +      Q+     + E EK+   +D +     
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244

Query: 820  ---SQETKIQHEELNNR-----IQTTVTELQKVKMEKEALM-----------TELSTVKD 860
                Q  +++  +L +R     +Q  + E Q+   E+E               +L   + 
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
            K +K  D     + +  +E ++ K    + ++  +E +  LQ + E  L+ Q+  +K   
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF-- 1362

Query: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL--QGNINELKQSSEQKKKQIEAL 978
            +E+E  HQ +      +EQ ++ Q   ++  KEEQQL  Q    +L+Q  ++K ++ E  
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE-- 1420

Query: 979  QGELKIAVLQKTELENKL---QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
                    L + E + K    +QQ+ +  +E    +E+  + Q  + K +E  + LQ   
Sbjct: 1421 ------QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE-- 1472

Query: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
               E +L    +D K +EE+  L +++          +++  +E +      E+   ++E
Sbjct: 1473 -REEQQLHRQERDRKFLEEEQQLRRQE----------RDRKFREQELRSQEPERKFLEEE 1521

Query: 1096 QQLQERCKALQDIQKEKSLKEKELVNEK-----SKLAEIEEIKCRQEKEITKLNEELKSH 1150
            QQL  + +  + +Q+E+ L+ +E   ++      K  E E+++  +E++     E  +  
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581

Query: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE-KRNQQILKDQVKKE--EEEL 1207
            +LE  K     ++ K +  +Q+L  Q     L+   +++ + ++Q+L+++ +++   +E 
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641

Query: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
             ++F+E+E +L  + +E+++      + + K   +   L E      +  Q   R+  E 
Sbjct: 1642 DRKFLEEEPQLRRQEREQQL----RHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREE 1696

Query: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
            E+Q      E   L    Q  Q  RR  LER  + E ++ + +T+  +L+R+        
Sbjct: 1697 EQQLRRQERERKFL----QEEQQLRRQELERKFREEEQLRQ-ETEQEQLRRQERYRKILE 1751

Query: 1328 QELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
            +E  R  +  Q    Q  +RK+ E+ +++
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLR 1780



 Score =  163 bits (412), Expect = 1e-39
 Identities = 223/1019 (21%), Positives = 478/1019 (46%), Gaps = 81/1019 (7%)

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ-LGEA 433
            ++ +E+    E + + L+ E  Q ++Q+ ++++  L    E ++   +L + +RQ   E 
Sbjct: 113  RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172

Query: 434  HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
              R +++ Q   E+  ++EQ  +    K    EE   E+     EL     K +++ Q+Q
Sbjct: 173  LWRQRQEWQEREERRAEEEQLQS---CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQ 229

Query: 494  QALQQSTTAKLREAQ--NDLEQVLRQIGDKDQKIQNLEALLQK--SKENISLLEKEREDL 549
            +  +Q    +  E +     E VLR+   +++K+Q  E   Q+   +E   L + ER++L
Sbjct: 230  RRERQDRVFQEEEEKEWRKRETVLRK---EEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286

Query: 550  YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
              + Q  E +   L + Q+     +E+  +  E+ + Q E  +Q +E    Q++ ++   
Sbjct: 287  RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346

Query: 610  RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
            R  Q R    E    +   +  E + +  QL  + + + E  L  E     Q+   +  L
Sbjct: 347  REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE-----QQLRREQQL 401

Query: 670  DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
               Q  L+ +QQ   +   + +Q   + Q+++ H    + H +E +E+ L  EQ  EE  
Sbjct: 402  RREQQ-LRREQQLRREQQLRREQQLRREQEEERH---EQKHEQERREQRLKREQ--EERR 455

Query: 730  GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
              +K+ E    E +  +++     ++++QL  D E    E   +LE E+      R + Q
Sbjct: 456  DWLKREE----ETERHEQE-----RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506

Query: 790  KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
             + E  E  +Q+L +QEEE+++ ++    L  E +++ E+   R Q    E +K ++E+E
Sbjct: 507  LRREQEERREQRLKRQEEEERLQQR----LRSEQQLRREQEERREQLLKREEEK-RLEQE 561

Query: 850  ----ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ-KGKAAILDLEKTCKELKHQLQVQ 904
                 L  E    +D+L K  +  +  + + E+E + + +    ++E+  +E + + +++
Sbjct: 562  RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 905  MENTLKEQK-ELKKSLEKEKEASHQLKLELNSMQEQLIQ--------AQNTLKQNEKEEQ 955
             E   +E++ +L KS E+E+    QL+ E    +EQ ++         Q   +++E+E +
Sbjct: 622  REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 956  QLQGNINELKQSSEQKKKQIEALQGELKI-AVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
            + +    E +Q+ E+ K +I   Q +L+  A  +++++ ++ ++Q  Q  ++   EK + 
Sbjct: 682  EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR 741

Query: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN 1074
               +  +++ +   +Q Q +   R+       ++ KS   +  L+    +  + +   + 
Sbjct: 742  RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE-KSERGRQRLSARPPLREQRERQLRA 800

Query: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE----LVNEKSKLAEIE 1130
            +  Q+ +      E++  ++ +Q +ER K LQ +++E+ L+ +E    L  E+  L E +
Sbjct: 801  EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860

Query: 1131 EIKCRQE-----KEITKLNEELK--SHKLESIKEI-TNLKDAKQLLIQQKLELQGKADSL 1182
            E +  QE     K   +L EE K   H L +   +   L+  +QLL +++ ELQ +    
Sbjct: 861  ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920

Query: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
            +   EQE++ ++  ++Q+++EEE+L +E  E+E +   E + +    KK ++ E +L  +
Sbjct: 921  RRRQEQERQYRE--EEQLQQEEEQLLRE--EREKRRRQERERQYRKDKKLQQKEEQLLGE 976

Query: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ-----NNQDERRALLE 1297
                 E     ++E +   R   EL+++ + L  E        +       +DE +   E
Sbjct: 977  -----EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031

Query: 1298 RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
            + L+ E E  +LQ +  + + + +      Q LG E ++   +  Q L R++ ++ E+Q
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET---RRRQELERQYRKEEELQ 1087



 Score =  159 bits (403), Expect = 1e-38
 Identities = 217/1053 (20%), Positives = 482/1053 (45%), Gaps = 114/1053 (10%)

Query: 366  ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS-KLL 424
            EL+E  E ++K +E L + + + +      ++L +QR+E ++   + ++E  QL S K  
Sbjct: 147  ELAEGEEQSEK-QERLEQRDRQRRD-----EELWRQRQEWQERE-ERRAEEEQLQSCKGH 199

Query: 425  ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484
            ETE    E   R +E  +L  +   +K+QQ  + Q ++ + EE+ KE     T L+ + +
Sbjct: 200  ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ-EEEEKEWRKRETVLRKEEE 258

Query: 485  KTKQQHQEQQALQQSTTAKLREAQ-NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
            K +++  ++Q   Q    +LR+ +  +L +  ++   + Q+++  + L +K +E     +
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 544  KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
            +ER +   + +  E       + +++    Q+   +  E+ + Q    +Q +E    Q++
Sbjct: 319  EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 604  EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
             ++   R  Q R         +L  +    +E+  + + Q++ + +L    E  +  Q+ 
Sbjct: 379  REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK- 437

Query: 664  DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE- 722
                H    +     ++QE  +   + ++ T + + ++          +E +E++L LE 
Sbjct: 438  ----HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493

Query: 723  ----QKTEELEGQIKKLEADSLEVKASKEQALQDLQQ----QRQLNTDLELRATEL---- 770
                ++ E  E Q+++ + +  E +  +++  + LQQ    ++QL  + E R  +L    
Sbjct: 494  EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553

Query: 771  -SKQLEMEKEIVSSTRLDLQKKSEAL----ESIKQKLTKQEEEK---QILKQDFETLSQE 822
              K+LE E+      R   +++ + L    E  +Q+L +++EE+   ++ +++ E L QE
Sbjct: 554  EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 823  ------TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK---NSK 873
                   K +  E   R Q   +E Q+ + +++    +    + +L +  +  +     K
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673

Query: 874  SEFEKENQKGKAAILDLEKTCKELKH-----QLQVQMENTLKEQKELKKSLEKEKEASHQ 928
             E E+E ++ + A  + E+  + +K      Q Q++ E   ++ K   +  ++E +   Q
Sbjct: 674  REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733

Query: 929  LKLELNSMQEQLIQAQNTLK-QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
             + E    +E  +Q Q   +   +++E++ + +     Q+ E+ ++  + L     +   
Sbjct: 734  EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793

Query: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
            ++ +L  + +QQ  Q  + L  E+EK    +    + +E  K+LQ   +  E E L  R+
Sbjct: 794  RERQLRAEERQQREQ--RFLPEEEEK----EQRRRQRREREKELQ---FLEEEEQLQRRE 844

Query: 1048 DLKSVEEKLSLAQEDLISNRN-----------QIGNQNKLIQELKTAKATLEQDSAKKEQ 1096
              + ++E+    QED    R+           Q+  + K  +    AK  L++   K++Q
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904

Query: 1097 QLQERCKALQDIQKEKSLKEKE--LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
             LQE  + LQ  ++EK  ++++     E+ +L + EE   R+E+E  +  E  + ++   
Sbjct: 905  LLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR--- 961

Query: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
                   KD K  L Q++ +L G+    +   E+EK+ ++  ++++++EEE+L +E  EK
Sbjct: 962  -------KDKK--LQQKEEQLLGEEPEKRRRQEREKKYRE--EEELQQEEEQLLREEREK 1010

Query: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
              +     +E E   +K +E + +    +    E     ++E Q   R   EL+++ + L
Sbjct: 1011 RRR-----QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ--YREEEELQQEEEQL 1063

Query: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL------ELQRKLDNTTAAVQ 1328
             GE           +  RR  LER  + E E+++ + ++L        +++ +      +
Sbjct: 1064 LGE---------ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 1329 ELGRENQSL-----QIKHTQALNRKWAEDNEVQ 1356
            EL +E + L     + +  Q L R++ E+ EVQ
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147



 Score =  142 bits (358), Expect = 2e-33
 Identities = 203/1034 (19%), Positives = 451/1034 (43%), Gaps = 97/1034 (9%)

Query: 80   LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS----A 135
            L++++  LLR+E ++ +   + E+ Y ++ K + ++ Q L ++  K      +       
Sbjct: 936  LQQEEEQLLREE-REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994

Query: 136  ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
            ELQ  E+QL   + E    ++ +  + +K  +L  E   +  +  E+R L+E   Q   R
Sbjct: 995  ELQQEEEQLLREEREKRRRQEWERQYRKKD-ELQQEEEQLLREEREKRRLQERERQY--R 1051

Query: 196  LTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
              EEL +E   +   + E  +R  +E     ++EL Q +  +     E+ R  E+ + +C
Sbjct: 1052 EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER-QC 1110

Query: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
            ++ +      E  + + R +  +         QEL++      E+ Q+     E LL++E
Sbjct: 1111 REEEELQQEEEQLLREEREKRRR---------QELERQYREEEEVQQEE----EQLLREE 1157

Query: 316  QDYTK---LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
             +  +   LE ++ EE   ++  +  L ++    +Q + R    E  L R   +   + E
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217

Query: 373  ATQK-LK-----EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
              +  LK     E+ + V     + K    +  +Q E+ +    Q Q ++  L  +  E 
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277

Query: 427  ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
            +R+      + +++     E+L  +EQ+ A  + + S+ E+QL  +       + + D+ 
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337

Query: 487  -------KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI--QNLEALLQKSKE 537
                    Q+ +EQ   +Q    K RE +   ++  R+  +++Q++  Q  E    K ++
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397

Query: 538  NISLLEKE---REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA 594
             +   E+E   R+D   K +  E E  +  Q +++    +EQ  +  E+ +   E  +Q 
Sbjct: 1398 QLRCQEREQQLRQDRDRKFR--EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455

Query: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
            ++  H + +E++  L+  +++ L  +    E + +  E ++++ + +   K + + L S 
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511

Query: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
            E  +     + Q H    Q     ++Q+L +     ++   + QD+     + E   +E 
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRR----QERGQQRRQDRDRKFREEEQLRQER 1567

Query: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDLELRATELSKQ 773
            +E+ LS +++  +   + +K+     E K  + EQ L+  + Q+QL  + + +  E  +Q
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE-DEQ 1626

Query: 774  LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
            L  E+E                   +Q+L +QE +++ L+++ +   QE   + ++L + 
Sbjct: 1627 LLQERE-------------------EQQLHRQERDRKFLEEEPQLRRQE---REQQLRHD 1664

Query: 834  IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
                  E +++  E E           K  +    L+  + E +   ++ +    +LE+ 
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724

Query: 894  CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
             +E +   Q   +  L+ Q+  +K LE+E+    + + +L   +      +    + E+E
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784

Query: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL-----QQQLTQAAQELA 1008
            EQQL+       Q S++K ++ E L+ E +   L+  + + K      Q QL +  Q L 
Sbjct: 1785 EQQLR------SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838

Query: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068
             E+++       Y   ++   Q +S    RE + L   ++ K  +E+    +E+ I  + 
Sbjct: 1839 QERDR------QYRAEEQFATQEKS---RREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889

Query: 1069 QIGNQNKLIQELKT 1082
            +   +++ + E+K+
Sbjct: 1890 KEEQRHRQVGEIKS 1903



 Score =  136 bits (343), Expect = 1e-31
 Identities = 199/993 (20%), Positives = 427/993 (43%), Gaps = 163/993 (16%)

Query: 423  LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
            LL+  RQ  +        RQL  E    + Q+  + + +L+  EEQ        +E Q +
Sbjct: 109  LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ--------SEKQER 160

Query: 483  LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI-GDKDQKIQNLEALLQKSKENISL 541
            L++  +Q ++++  +Q    + RE +   E+ L+   G + ++  + E L  + +E + L
Sbjct: 161  LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL--RRRELLEL 218

Query: 542  LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
              K RE+   + Q  E +  V  + +EK    +E V +  E+   + E  +Q +      
Sbjct: 219  RRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE------ 270

Query: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
            +QE++  LR  +               +L   +++  Q   +++ + +L    E  +  Q
Sbjct: 271  LQEEEEQLRKLE-------------RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317

Query: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
            + + +   +  +   + ++Q+L +   Q ++   +L+ +QE         +E +E+ L  
Sbjct: 318  QEERREQQERREQQEERREQQLRR--EQEERREQQLRREQE---------EERREQQLRR 366

Query: 722  EQKTEELEGQIKKLEADSLEVKASKEQAL---QDLQQQRQLNTDLELRATELSKQLEMEK 778
            EQ+ E  E Q+++ +    E +  +EQ L   Q L++++QL  + +LR  +   QL  E+
Sbjct: 367  EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ---QLRREQ 423

Query: 779  EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
            ++      +  ++    E  +Q+L +++EE++      + L +E + +  E   R Q   
Sbjct: 424  QLRREQEEERHEQKHEQERREQRLKREQEERR------DWLKREEETERHEQERRKQQLK 477

Query: 839  TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
             + ++ + E+   + E                    E  +E Q         E+  ++L+
Sbjct: 478  RDQEEERRERWLKLEE--------------------EERREQQ---------ERREQQLR 508

Query: 899  HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
             + + + E  LK Q+E ++ L++   +  QL+ E    +EQL      LK+ E++  + +
Sbjct: 509  REQEERREQRLKRQEE-EERLQQRLRSEQQLRREQEERREQL------LKREEEKRLEQE 561

Query: 959  GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
                 LK+  E+++ Q+   + E +   L K E E +L+Q+L +   E   ++E+     
Sbjct: 562  RREQRLKREQEERRDQLLKREEERRQQRL-KREQEERLEQRLKREEVERLEQEERREQRL 620

Query: 1019 NNYEKSQETFKQL---QSDFYGRESELLATRQD-----LKSVEEKLSLAQEDLISNRNQI 1070
               E  +E  +QL   +     R+ +L   +Q+     LK  EE+  L Q     +  + 
Sbjct: 621  KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680

Query: 1071 GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE 1130
              Q    +E + A+  ++    K + QL+    A Q     +  K++     + +  E E
Sbjct: 681  REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE----GQRRRQEQE 736

Query: 1131 EIKCRQEKEITKLNEELKSHKLESIKE----------ITNLKDAKQLLIQQKLELQGKAD 1180
            E + R+E E+ +  EE ++H+ +  +E               +  +  +  +  L+ + +
Sbjct: 737  EKRRRRESEL-QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795

Query: 1181 SLKAAVEQEKRNQQILKDQVKKE-------EEELKKEFIEKEAKLH-----SEIKEKEVG 1228
                A E+++R Q+ L ++ +KE       E E + +F+E+E +L       +++E+E G
Sbjct: 796  RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855

Query: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRR-------------VSELEKQTDDLR 1275
            +++ +E             E     K  WQ  + R               +L K+   L+
Sbjct: 856  LQEDQERRRS--------QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907

Query: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQ 1335
             E   L+   +  +  RR   ER  + E ++++ + ++L  +R+        ++  R+++
Sbjct: 908  EEEEELQR--EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY-RKDK 964

Query: 1336 SLQIKHTQAL------------NRKWAEDNEVQ 1356
             LQ K  Q L             +K+ E+ E+Q
Sbjct: 965  KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 132/607 (21%), Positives = 262/607 (43%), Gaps = 90/607 (14%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELK------KELEKYQGLQQQEAKPDG 128
            E++   + ++  L  +E Q L+   ++ K+  EEL+      K LE+ Q L++QE +   
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF 1392

Query: 129  LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
            L  +     Q  EQQL + +   F          ++  QL+ +  D K + +E++  R+ 
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFR---------EEEQQLSRQERDRKFREEEQQVRRQE 1443

Query: 189  AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
             E+K     ++L +E       + +LLQ     +   L ++    + L +   L R+   
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEEQLLQE---REEQQLHRQERDRKFLEEEQQLRRQERD 1500

Query: 249  EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
             K +++  +L+SQ    E    +   +L +  Q    ++QE Q+L+       ++ Q   
Sbjct: 1501 RKFREQ--ELRSQ--EPERKFLEEEQQLHR-QQRQRKFLQEEQQLRRQ-----ERGQQRR 1550

Query: 309  ENLLKKEQDYTKLEEKHNEESVSK--KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
            ++  +K ++  +L ++  E+ +S+  ++ +  L ++ +  Q+ + +    E  L R   +
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610

Query: 367  LSEKGEATQKLKEE---LSEVETKYQH--------LKAEFKQLQQQREEKEQHGL----- 410
               + E  +K +E+   L E E +  H        L+ E +  +Q+RE++ +H       
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670

Query: 411  ---QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
               QL  E  +   +  E +R+  E   +L+ Q +    K + +EQQ+   +L+    EE
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER--ERKFLQEEQQLRRQELERKFREE 1728

Query: 468  QLKEKVTNSTELQHQL--------DKTKQQHQEQQALQQSTTAKLREA----QNDLEQVL 515
            +   + T   +L+ Q         ++ + + +EQQ  +Q    K RE     Q   EQ L
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788

Query: 516  RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA----KIQAGEGETAVLNQ------ 565
            R   + D+K +  E L Q+ +E   L  ++R+  Y     ++Q  E E  +  +      
Sbjct: 1789 RS-QESDRKFREEEQLRQEREEQ-QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846

Query: 566  ------LQEKNHTLQEQVTQLTEKLKNQSESHK---------QAQENLHDQVQEQKAHLR 610
                   QEK+   ++++ Q  E+ + Q    K         Q +E  H QV E K+   
Sbjct: 1847 AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEG 1906

Query: 611  AAQDRVL 617
                R+L
Sbjct: 1907 KGHGRLL 1913



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 85/408 (20%), Positives = 188/408 (46%), Gaps = 40/408 (9%)

Query: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKE-LEKYQGLQQQEAKPDGLVTDS 133
            E  L  +R++  L RQE +D +  L+E+K   +E +++ +E  Q L++QE +   L  + 
Sbjct: 1560 EEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ-LRQER 1617

Query: 134  SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA----- 188
              + +  EQ L+E + +  + ++    F ++  QL  +  + + ++D +R  RE      
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677

Query: 189  -AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE 247
              E++  R  E   K     Q L+ +  +R  +++   L+++ ++ +   +   L +E E
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE-RKFREEEQLRQETE 1736

Query: 248  SEKLKDE---CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
             E+L+ +    K L+ +    E    QLR       QE     +E ++L+    E   ++
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRR------QERDRKFREEEQLRQEREEQQLRS 1790

Query: 305  QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
            Q       ++EQ   + E +  +    +++ +    ++ L  ++ + RL       +R  
Sbjct: 1791 QESDRKFREEEQ--LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE 1848

Query: 365  VELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL 424
             + + + ++ ++ +E   E E K        ++ +++R+ +E+H ++ Q +  Q H ++ 
Sbjct: 1849 EQFATQEKSRREEQELWQEEEQK--------RRQERERKLREEH-IRRQQKEEQRHRQVG 1899

Query: 425  ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK 472
            E + Q G+ HGRL E              Q A + ++ S L E ++E+
Sbjct: 1900 EIKSQEGKGHGRLLE----------PGTHQFASVPVRSSPLYEYIQEQ 1937


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  198 bits (504), Expect = 3e-50
 Identities = 301/1390 (21%), Positives = 605/1390 (43%), Gaps = 137/1390 (9%)

Query: 35   ESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQD 94
            +S   G   P    S   A  +  H  A HD   D G     ++   + ++  L  EV  
Sbjct: 129  QSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFG-----DIISSQQEINRLSNEVSR 183

Query: 95   LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAEL-QSLEQQLEEAQTENFN 153
            L++ +   +  ++       K QG    +      + +   EL Q+  Q++++ Q E   
Sbjct: 184  LESEVGHWRHIAQT-----SKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHE--- 235

Query: 154  IKQMKDLFEQKAAQLAT----EIADIKSKYDEERSLREAAEQKV--TRLTE--ELNKEAT 205
            +  +++  +QK  +++     E++D + + +E  +L +     V  T L++  E+ K   
Sbjct: 236  MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQ 295

Query: 206  VIQDLKTELLQR-PGIED-VAVLKKELVQVQTLMDNMTLERER----------ESEKLKD 253
            V+Q  K E  ++   +ED +  + K+L   +   D +  E+E+          E E LK 
Sbjct: 296  VLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKL 355

Query: 254  ECKKLQSQYASSEATISQLRSELAKGP--QEVAVYVQELQKLKSSVNELTQKNQ--TLTE 309
            EC KLQ        T+++    LA+    +EV    Q L   ++ +  L+  NQ  +L E
Sbjct: 356  ECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAE 415

Query: 310  NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS---ETSLHRIHVE 366
            + LK +     LE++ +  S  K+ +Q +L + + + + ++S  +     ++ LH + + 
Sbjct: 416  DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLN 475

Query: 367  LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL----QLQSEINQLHSK 422
            L  K    Q+L + +SE ET    L AE ++L +Q +E  +H +    QL  + N+  S 
Sbjct: 476  LEAK---EQELNQSISEKET----LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI 528

Query: 423  LLETERQLGEAHGRLKE----------QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK 472
            + + ++ L +   R+ +          +  +  EKL+  E  + DL L   +LE++++  
Sbjct: 529  ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL 588

Query: 473  VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD---KDQKIQNLE 529
            V    + Q      ++++ E +   +    +L   +N+L Q L Q  +   KD  ++  E
Sbjct: 589  VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648

Query: 530  ALLQKSKENISLLEKEREDL--YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
            A ++  K+N+S LE+  E+L   A     E E  VL   ++  H L+E +        NQ
Sbjct: 649  AEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL-ACEDVRHQLEECLAG-----NNQ 702

Query: 588  SESHKQA-QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
                K    E L  +  E +A L  A+ R+L      N+    + E     +     ++ 
Sbjct: 703  LSLEKNTIVETLKMEKGEIEAELCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQL 759

Query: 647  KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ---EH 703
            + E L+     K  + A+L+ +++      ++ +  L+    +  Q+T  +  K+   E 
Sbjct: 760  EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK 819

Query: 704  CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
              +  S L+E  +KY    +K E L   I++ +     +K       ++L++ R+  +  
Sbjct: 820  LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879

Query: 764  ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
               A    K L+   E+ S        K    E IK      E++ Q   Q  ++L ++ 
Sbjct: 880  APVAD--PKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQK 937

Query: 824  K------IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
            K       QHE++N     T T+L   K E      E+ +++  + ++   L   + + +
Sbjct: 938  KEMDEFRYQHEQMN----ATHTQLFLEKDE------EIKSLQKTIEQIKTQLHEERQDIQ 987

Query: 878  KEN----QKGKAAILDLEKTCKELKHQL-QVQMENTLK--EQKELKKSLEKEKEASHQLK 930
             +N    Q+ K   L++E   +  KH L + + E  +K  +++EL+  L  EK  S   +
Sbjct: 988  TDNSDIFQETKVQSLNIENGSE--KHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQ 1045

Query: 931  LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE----QKKKQIEALQGELKIAV 986
            ++  S ++++ +    ++Q + E Q L   I+    + +    Q++ Q  A++ E   AV
Sbjct: 1046 IDQLS-KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAV 1104

Query: 987  L-QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
            L +KT   + L+ +  +    +AA++  +  LQ+  +K    F+    D +    + L+ 
Sbjct: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164

Query: 1046 RQDLKSVE-EKLSLAQEDLI------SNRNQIGNQN-KLIQELKTAKATLEQDSAKKEQQ 1097
                K +E + LS   + L+      S  N+ G  N    +EL   +  L+Q   K E+ 
Sbjct: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224

Query: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL--NEELKSHKLESI 1155
             Q+    +Q++Q E +  ++EL   ++++    +   + + + T L  + E    KL++ 
Sbjct: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF 1284

Query: 1156 -KEITNLKDAKQLLIQQKLELQGKAD-------SLKAAVEQEKRNQQILKDQVKKEEEEL 1207
             +E+  ++ +   L   K  L GK D       S      Q     +  K +V  E  EL
Sbjct: 1285 GQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344

Query: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
             ++ +E   +L   ++EK+  ++  +EN  +L+  I A +E     +KE + +   + +L
Sbjct: 1345 LQQELE---ELRKSLQEKDATIRTLQENNHRLSDSIAATSE---LERKEHEQTDSEIKQL 1398

Query: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
            +++ D L+  +   +  ++   D+  +  E       E E L+  V  L+ ++      +
Sbjct: 1399 KEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDI 1458

Query: 1328 QELGRENQSL 1337
             +L  EN+ +
Sbjct: 1459 GKLKGENEKI 1468



 Score =  183 bits (465), Expect = 9e-46
 Identities = 307/1463 (20%), Positives = 634/1463 (43%), Gaps = 268/1463 (18%)

Query: 52   SADELFKHYEAVHDAGND---------SGHGGESNLALK------RDDVTLLRQEVQDLQ 96
            S +E+F+  +A+ DA N+              E NL LK        + +LL QE ++LQ
Sbjct: 383  SVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442

Query: 97   ASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQ 156
             SL +       L  E E  +    ++   D  + D    L++ EQ+L ++ +E   +  
Sbjct: 443  MSLLK-------LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIA 495

Query: 157  MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216
              +  +++  +    +  IK +  ++++     +  +++L ++LN E   +  L+ + + 
Sbjct: 496  EIEELDRQNQEATKHMILIKDQLSKQQN---EGDSIISKLKQDLNDEKKRVHQLEDDKMD 552

Query: 217  RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK---DECKKLQSQYAS--------- 264
                +++ V K++L+Q +  ++++ L +++  +K++   D+  K Q    S         
Sbjct: 553  IT--KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELK 610

Query: 265  -----SEATISQLRSELAKGPQE----------VAVYVQELQKLKSSVNELTQKNQTLTE 309
                 +E  +S++R+EL +   +          +     E++ LK +++EL Q N+ L +
Sbjct: 611  EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKK 670

Query: 310  NLLKKEQDYTKL-----EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
                 + +  KL     + +H  E     N Q +L +K+   + L+      E  L    
Sbjct: 671  VAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSL-EKNTIVETLKMEKGEIEAELCWAK 729

Query: 365  VELSEKGEATQKLKEELSEVET-KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
              L E+    +K  EELS         L+ E + L +  ++K+    +L+  I Q+ +  
Sbjct: 730  KRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDH 789

Query: 424  LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
             ET+  L  +   L+EQ+QL+  +L++K++             E+LKE+   S++LQ +L
Sbjct: 790  KETKDVLSSS---LEEQKQLT--QLINKKEIFI----------EKLKER---SSKLQEEL 831

Query: 484  DKTKQQHQEQQALQQSTTAK------LREAQNDLEQVLRQIGDKDQKI------QNLEAL 531
            DK  Q  ++ + L+Q+   K      ++E  N L++ L ++ ++  +       + L+++
Sbjct: 832  DKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSV 891

Query: 532  LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591
             + + E +S L   +E L  +I+  +        ++++N +  + +  L E+ K   E  
Sbjct: 892  TELASE-VSQLNTIKEHLEEEIKHHQ------KIIEDQNQSKMQLLQSLQEQKKEMDEFR 944

Query: 592  KQAQENLHDQVQEQKAHLRAAQDR-VLSLETSVNELNSQLNESKE-------------KV 637
             Q     H+Q+      L   +D  + SL+ ++ ++ +QL+E ++             KV
Sbjct: 945  YQ-----HEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKV 999

Query: 638  SQLDIQIKAKTELLLSAEA---AKTAQRADLQNHLDTAQNALQDKQ------QELNKITT 688
              L+I+  ++   L  AE     K  +  +L+  L   +N    KQ       E+ K+T 
Sbjct: 1000 QSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQ 1059

Query: 689  QLDQVTAKLQDKQEHCS-------------QLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
             + Q   ++Q      S             QL+++  E ++ +  L +KT E    +K  
Sbjct: 1060 IIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-NSHLKTE 1118

Query: 736  EADSLEVKASKEQALQDLQQQ-RQLNTDLELRATELSKQ-LEMEKEIVSSTRLD---LQK 790
                +++ A+KE AL  LQ + ++L+T  E    ++ ++ ++    I+    ++   L +
Sbjct: 1119 YHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQ 1178

Query: 791  KSEALESIKQKLTKQEEEKQILKQDFETLSQET---KIQHEELNNRIQTTVTELQKVKME 847
            K + L ++ Q  +   E   +    FE L QE    K Q +++    Q  +T +Q ++ E
Sbjct: 1179 KCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHE 1238

Query: 848  KEALMTELSTVKDKLSKVSDS---------------------LKNSKSEFE--------- 877
               L  EL  ++ ++   SD+                     LKN   E           
Sbjct: 1239 SAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298

Query: 878  ---KENQKGKAAILDLEKTCKEL-------------KHQLQVQMENTLKEQKELKKSLEK 921
               K+   GK  I+  + +   L                L    E   +E +EL+KSL+ 
Sbjct: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ- 1357

Query: 922  EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
            EK+A+ +   E N      I A + L++  KE +Q    I +LK+  +  +K ++     
Sbjct: 1358 EKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415

Query: 982  LKIA---VLQKTE-LENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
            +K     +L   E   NK+ +   L QA   L   KE+I +L+ +  K +   +++   +
Sbjct: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNL---KERILILEMDIGKLKGENEKIVETY 1472

Query: 1036 YGRESELLATRQ--------------DLKSVEEKLSLAQEDLISNR--------NQIGNQ 1073
             G+E+E  A ++              +  S++EK +LA E L+  +        NQ+ N 
Sbjct: 1473 RGKETEYQALQETNMKFSMMLREKEFECHSMKEK-ALAFEQLLKEKEQGKTGELNQLLNA 1531

Query: 1074 NKLIQELKTAKATLEQDS---AKKEQQLQE----------RCKALQDIQKEKSLKEKELV 1120
             K +QE KT     E+D    A K++Q++           R K  +  Q+ + L+   L 
Sbjct: 1532 VKSMQE-KTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590

Query: 1121 NEKSKLAEI---EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG 1177
            +E S   E    E+ + +  K++T L E+L S    +++  ++    +   +Q++L +  
Sbjct: 1591 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSS-NAMENASHQASVQVESLQEQLNVVS 1649

Query: 1178 KA---DSLKAAVEQEK--------RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
            K     +L+ +V QE+         N Q++ +  ++EE+ +    +EK+ +L +E K+  
Sbjct: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNA 1709

Query: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
              ++    +  +   +  A  ++   + ++    + ++ EL++Q ++LR E+        
Sbjct: 1710 ENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ-NELRQEML------- 1761

Query: 1287 NNQDERRALLERCLKGEGEIEKL 1309
               D ++ L+      EG+++K+
Sbjct: 1762 --DDVQKKLMSLANSSEGKVDKV 1782



 Score =  176 bits (445), Expect = 2e-43
 Identities = 255/1217 (20%), Positives = 519/1217 (42%), Gaps = 165/1217 (13%)

Query: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
            E+E+LK  C  L+ ++ +SE  I           Q+   Y  +LQ+ +  ++ L  +   
Sbjct: 67   ENERLKKLCTDLEEKHEASEIQIK----------QQSTSYRNQLQQKEVEISHLKARQIA 116

Query: 307  LTENLLKKEQDYTKLEEKHNEESVSKKNIQA--------TLHQKDLD------CQQLQSR 352
            L + LLK +     +       + +  +  A          H  D+D       QQ  +R
Sbjct: 117  LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINR 176

Query: 353  LSASETSL-----HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
            LS   + L     H  H+  + K + T     + SE+  K Q++  E KQ + Q  +  Q
Sbjct: 177  LSNEVSRLESEVGHWRHIAQTSKAQGTD--NSDQSEI-CKLQNIIKELKQNRSQEIDDHQ 233

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
            H + +    +Q   KL E  R+  E     +E+ +     L      V  ++  LS++ E
Sbjct: 234  HEMSVLQNAHQ--QKLTEISRRHREELSDYEERIEELENLLQQGGSGV--IETDLSKIYE 289

Query: 468  QLK-------EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
              K       EKV ++ +++   DK K  +++  + +      LR  Q  L    RQI +
Sbjct: 290  MQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDI-LRREQEQLNVEKRQIME 348

Query: 521  KDQKIQNLEALLQKS--KENISLLEKER--------EDLYAKIQA---GEGETAVLNQLQ 567
            + + ++   + LQ S  K++ ++ EKER        E+++   QA    E E   L+ L 
Sbjct: 349  ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLN 408

Query: 568  EKNHTLQEQV-----TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
            + N   ++ +      ++ EK K+     K+  +    ++  +   +++   R +SL++ 
Sbjct: 409  QDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSE 468

Query: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
            +++L   L E+KE+  +L+  I  K  L+   E     Q  +   H+   ++ L  +Q E
Sbjct: 469  LHDLRLNL-EAKEQ--ELNQSISEKETLIAEIEEL-DRQNQEATKHMILIKDQLSKQQNE 524

Query: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
             + I ++L Q    L D+++   QLE    +  ++    ++K  + E  +  L     ++
Sbjct: 525  GDSIISKLKQ---DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581

Query: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK--KSEALESIKQ 800
            +   E  +  L + ++ N  ++    EL + +   +E +S  R +L +    ++  + K 
Sbjct: 582  EDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD 641

Query: 801  KLTKQEE-EKQILKQDFETLSQ----------ETKIQHEEL-----------------NN 832
             L K+ E E + LKQ+   L Q          + K+++E+L                 NN
Sbjct: 642  TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNN 701

Query: 833  RIQTTV-TELQKVKMEKEALMTELSTVK-------DKLSKVSDSLKNSKS--------EF 876
            ++     T ++ +KMEK  +  EL   K       +K  K  + L N+++        E 
Sbjct: 702  QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH 761

Query: 877  E---KENQKGKAAILDLEKTCKEL---KHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
            E   K NQK    I +L+K  +++     + +  + ++L+EQK+L + + K++    +LK
Sbjct: 762  EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLK 821

Query: 931  LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990
               + +QE+L +    L++NE     L+  I E  +S    K++   LQ EL+    +++
Sbjct: 822  ERSSKLQEELDKYSQALRKNE----ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS 877

Query: 991  ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
                    +   +  ELA+E  +++ ++ + E+  +  +++  D    + +LL + Q+ K
Sbjct: 878  RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQK 937

Query: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110
               ++     E + +   Q+  +    +E+K+ + T+EQ   +  ++ Q+      DI +
Sbjct: 938  KEMDEFRYQHEQMNATHTQLFLEKD--EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ 995

Query: 1111 EKSLKEKELVN--EKSKLAEIE-------------EIKCRQEKEI--TKLNEELKSHKLE 1153
            E  ++   + N  EK  L++ E             EIK   EK I  TK  ++L   ++ 
Sbjct: 996  ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055

Query: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ------EKRNQQILKDQVKKEEEEL 1207
             + +I   KD +   +  ++        +    +Q      E+     + ++  +E   L
Sbjct: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL 1115

Query: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
            K E+     K+   +  KE  + K ++   KL+ +  +  +++   ++  Q+  R + E 
Sbjct: 1116 KTEY----HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRIIREK 1169

Query: 1268 EKQTDDLRGEIAVLEATVQNNQDERRA------LLERCLKGEGEIEKLQTKVLELQRKLD 1321
            + + D L  +   L A +Q +     A        E  L+   E +KL+ +V +++    
Sbjct: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ---ERDKLKQQVKKMEEWKQ 1226

Query: 1322 NTTAAVQELGRENQSLQ 1338
                 VQ +  E+  LQ
Sbjct: 1227 QVMTTVQNMQHESAQLQ 1243



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 127/617 (20%), Positives = 249/617 (40%), Gaps = 56/617 (9%)

Query: 67   GNDSGHGGESN----LALKRD----DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG 118
            GN++G G  SN    L  +RD     V  + +  Q +  +++  +  S +L++EL + Q 
Sbjct: 1193 GNEAG-GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251

Query: 119  LQQQEAKPDG-LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKS 177
                ++  +  L  D +  +QS EQ   E + +NF   Q     +    QL      +  
Sbjct: 1252 QVLVDSDNNSKLQVDYTGLIQSYEQN--ETKLKNFG--QELAQVQHSIGQLCNTKDLLLG 1307

Query: 178  KYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM 237
            K D       +A     +  E L    + +    +ELLQ+   E    L+++   ++TL 
Sbjct: 1308 KLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQ 1367

Query: 238  DN---------MTLERER--------ESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
            +N          T E ER        E ++LK++   LQ      +  I     +L    
Sbjct: 1368 ENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSN 1427

Query: 281  QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT-- 338
            +     V E + L+ +V  L ++   L  ++ K + +  K+ E +  +    + +Q T  
Sbjct: 1428 ENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNM 1487

Query: 339  -----LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
                 L +K+ +C  ++ +  A E  L     E  + GE  Q L   +  ++ K    + 
Sbjct: 1488 KFSMMLREKEFECHSMKEKALAFEQLLKE--KEQGKTGELNQLLNA-VKSMQEKTVVFQQ 1544

Query: 394  EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
            E  Q+    ++K+     LQ+E+ +L  K   + ++L      L E     + + +  E 
Sbjct: 1545 ERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED 1604

Query: 454  QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQN 509
            + A L+ K++ LEE+L           HQ     +  QEQ       +  T  +L  +Q 
Sbjct: 1605 REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQE 1664

Query: 510  DLEQVLRQIGDKDQKIQNLE--------ALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
             ++Q    + +    +++ +        A L+K K+ I+  +K  E+L  K+ + +    
Sbjct: 1665 QVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLD 1724

Query: 562  VLNQLQEKNHTLQEQV---TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
              N   +    L EQ+    +  E+LK Q+E  ++  +++  ++           D+VL 
Sbjct: 1725 EANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM 1784

Query: 619  LETSVNELNSQLNESKE 635
                +   ++  N+  E
Sbjct: 1785 RNLFIGHFHTPKNQRHE 1801


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  197 bits (501), Expect = 6e-50
 Identities = 236/1146 (20%), Positives = 507/1146 (44%), Gaps = 97/1146 (8%)

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            K L+QV T  D +   R +E +K+++  ++   +    +  ++QL  E A+  +++    
Sbjct: 867  KPLLQV-TRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 925

Query: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
            +   + + +   L  + Q L       E   ++LE +  EE    + +Q    +     Q
Sbjct: 926  ELCAEAEETRGRLAARKQEL-------ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ 978

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
            +L++ L A E +  ++ +E        +K +E+L  +E +   L  E K L+ +  E   
Sbjct: 979  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
               + + ++  L+   L+ E  + +   RL+++ +   E     E+    L  + S L+E
Sbjct: 1039 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE----LEKLKRRLDGESSELQE 1094

Query: 468  QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
            Q+ E+   + EL+ QL + +++        Q+  A+  +      Q+L+ + +    +  
Sbjct: 1095 QMVEQQQRAEELRAQLGRKEEE-------LQAALARAEDEGGARAQLLKSLREAQAALAE 1147

Query: 528  LEALLQKSKENISLLEKEREDLYAKIQAGEGETA----VLNQLQEKNHTLQEQVTQLTEK 583
             +  L+  +   +  EK+R DL  +++A  GE        N  QE     +++VT+L + 
Sbjct: 1148 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1207

Query: 584  LKNQS-----------ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN- 631
            L+ ++           + H QA   L +Q+++ +    A +   L+LE  V+EL ++L+ 
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1267

Query: 632  ------ESKEKVSQLDIQI-----KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
                  E +++  +L++Q+     +A       AEAA+  QRA  Q  L+    AL + +
Sbjct: 1268 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA--QAELENVSGALNEAE 1325

Query: 681  QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
             +  +++ +L    A+L D QE        L+E     L+L  +   +E +   L     
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQE-------LLQEETRAKLALGSRVRAMEAEAAGLREQLE 1378

Query: 741  EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
            E  A++E+A ++LQ  +   ++   R  E +  LE  +E         ++ +   E++ Q
Sbjct: 1379 EEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA-------RRRAAREAEALTQ 1431

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
            +L ++ E    L++    L QE      +L  + Q  V+ L+K + + + L+ E     +
Sbjct: 1432 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ-LVSTLEKKQRKFDQLLAE-----E 1485

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKA-----AILDLEKTCKELKHQ---LQVQMENTLKEQ 912
            K + +    +  ++E E   ++ +A     A+ + ++  +EL+ Q   L+ ++E  L  +
Sbjct: 1486 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK 1545

Query: 913  KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972
             ++ KS+ + + A    +   N ++ Q+ + ++ L   E  + +L+  +  LK   E+  
Sbjct: 1546 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD- 1604

Query: 973  KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
                 LQG  +    ++ +L  +L+    +  +E       ++  +    + +E   Q+ 
Sbjct: 1605 -----LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1659

Query: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
            S   G+E  +   R+ +++  ++L    E+  ++R +I +QN+   E +     LE +  
Sbjct: 1660 SAGQGKEEAVKQLRK-MQAQMKELWREVEETRTSREEIFSQNR---ESEKRLKGLEAEVL 1715

Query: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
            + +++L    +A +  Q+++     E+ N     A I E K + E  + +L EEL+    
Sbjct: 1716 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE-- 1773

Query: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
            +S  E+ N +  K LL  + L  +  A+   +A  +  R Q  L+ Q+++    L +E  
Sbjct: 1774 QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ--LERQIQELRGRLGEEDA 1831

Query: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
               A+    I   E  + + EE   + T +     + +   +K  +    +V E  +  D
Sbjct: 1832 GARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD 1891

Query: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332
             LR ++       +      + L  +  + E E  + Q     LQR+L++ T + + + R
Sbjct: 1892 QLRDQL-------EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1944

Query: 1333 ENQSLQ 1338
            E  +L+
Sbjct: 1945 EVTTLR 1950



 Score =  178 bits (451), Expect = 4e-44
 Identities = 244/1181 (20%), Positives = 510/1181 (43%), Gaps = 144/1181 (12%)

Query: 123  EAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE 182
            + KP   VT     LQ+  Q+L++ Q             +Q++A+   E+    ++ +EE
Sbjct: 865  KVKPLLQVTRQDEVLQARAQELQKVQE-----------LQQQSAREVGELQGRVAQLEEE 913

Query: 183  RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
            R+          RL E+L  EA    +L  E  +  G   +A  K+EL  V + ++    
Sbjct: 914  RA----------RLAEQLRAEA----ELCAEAEETRG--RLAARKQELELVVSELEARVG 957

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E  S +++ E K+LQ      EA +     E  +G +         QKL        Q
Sbjct: 958  EEEECSRQMQTEKKRLQQHIQELEAHL-----EAEEGAR---------QKL--------Q 995

Query: 303  KNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
              +  TE  +KK E+D   LE+++++ S  +K ++  L +      + + ++ +      
Sbjct: 996  LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1055

Query: 362  RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421
            +    +++  +  +K ++   E+E   + L  E  +LQ+Q  E++Q   +L++++ +   
Sbjct: 1056 KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1115

Query: 422  KL---LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
            +L   L      G A  +L +  + +   L + ++ +   ++  ++ E+Q ++       
Sbjct: 1116 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1175

Query: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE----------QVLRQIGDKDQKIQNL 528
            L+ +L+ T      QQ L+     ++ E +  LE          Q LRQ     Q +  L
Sbjct: 1176 LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ--RHGQALGEL 1233

Query: 529  EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
               L++++      EK R  L A++     E + L   +++    + ++    ++++ ++
Sbjct: 1234 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1293

Query: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV--SQLDIQIKA 646
               ++A+    +++Q  +A L      +   E+    L+ +L+ ++ ++  +Q  +Q + 
Sbjct: 1294 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1353

Query: 647  KTELLLSAEA-AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
            + +L L +   A  A+ A L+  L+    A +   +EL     QL +   + +++     
Sbjct: 1354 RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE 1413

Query: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
              E   +    +  +L Q+  E    + +LE     ++   + A  DL+QQRQL + LE 
Sbjct: 1414 AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1473

Query: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEA----LESIKQKLTKQEEEKQILKQDFETLSQ 821
            +  +  + L  EK  V    ++ ++++EA     E+    LT+  EE+           Q
Sbjct: 1474 KQRKFDQLLAEEKAAVLRA-VEERERAEAEGREREARALSLTRALEEE-----------Q 1521

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E + + E  N  ++  +  L   K +    + EL        + ++ L+   +E E E  
Sbjct: 1522 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1581

Query: 882  KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
              + A L LE T + LK Q +  ++   +  +E ++ L K+       ++E +  ++Q  
Sbjct: 1582 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ---LRDAEVERDEERKQRT 1638

Query: 942  QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
             A    K+ E E ++L+  +    Q  E+  KQ+  +Q ++K               +L 
Sbjct: 1639 LAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK---------------ELW 1683

Query: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
            +  +E    +E+I      + +++E+ K+L+    G E+E+L  +++L + +     AQ+
Sbjct: 1684 REVEETRTSREEI------FSQNRESEKRLK----GLEAEVLRLQEELAASDRARRQAQQ 1733

Query: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE---RCKALQDIQKEKSLKEK- 1117
            D     +++ N N     +   K  LE    + E++L+E     + L D  ++  L+ + 
Sbjct: 1734 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1793

Query: 1118 ---ELVNEKSKLAEIEEIKCRQEKEITKLNEEL--------KSHKLESIKEITNLKDAKQ 1166
               EL  E+S  A+ E  + + E++I +L   L          HK+      + L  A++
Sbjct: 1794 LTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1853

Query: 1167 LLIQQKLE--LQGK--------ADSLKAAVEQEKRNQQILKDQVKK---EEEELKKEFIE 1213
             L Q+  E  L GK           +   VE+E+R    L+DQ++K     ++LK++  E
Sbjct: 1854 QLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEE 1913

Query: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
             E     E    + G ++ +     +T    ++N  + T++
Sbjct: 1914 AE----EEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1950



 Score =  171 bits (433), Expect = 5e-42
 Identities = 238/1107 (21%), Positives = 497/1107 (44%), Gaps = 93/1107 (8%)

Query: 111  KELEKYQGLQQQEAKPDGLVTDSSAELQS----LEQQLE-------EAQTENFNIKQMKD 159
            +EL+K Q LQQQ A+  G +    A+L+     L +QL        EA+     +   K 
Sbjct: 884  QELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ 943

Query: 160  LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK-----TEL 214
              E   ++L   + + +    + ++ ++  +Q +  L   L  E    Q L+     TE 
Sbjct: 944  ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 1003

Query: 215  LQRPGIEDVAVLK---KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQ 271
              +   ED+ +L+    +L + + L+++   E   ++ + +++ K L       EATI+ 
Sbjct: 1004 KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD 1063

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +   L K  +      QEL+KLK     L  ++  L E +++++Q   + EE   +    
Sbjct: 1064 MEDRLRKEEKG----RQELEKLK---RRLDGESSELQEQMVEQQQ---RAEELRAQLGRK 1113

Query: 332  KKNIQATLHQKDLD---CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY 388
            ++ +QA L + + +     QL   L  ++ +L     +L  +  A  K +++  ++  + 
Sbjct: 1114 EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1173

Query: 389  QHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
            + L+ E +        +++   + + E+ +L  K LE E ++ EA   ++E RQ   + L
Sbjct: 1174 EALRGELEDTLDSTNAQQELRSKREQEVTEL-KKTLEEETRIHEA--AVQELRQRHGQAL 1230

Query: 449  MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
             +  +Q+   +      E+         +EL+ +L   +   QE +  ++    +L+E Q
Sbjct: 1231 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1290

Query: 509  NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
                   R   +  +K+Q  +A L    EN+S    E E    ++      T    QL +
Sbjct: 1291 GRAGDGERARAEAAEKLQRAQAEL----ENVSGALNEAESKTIRLSKELSSTEA--QLHD 1344

Query: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
                LQE+ T+    L ++  + +     L +Q++E+ A   A +     L+T+  +L+ 
Sbjct: 1345 AQELLQEE-TRAKLALGSRVRAMEAEAAGLREQLEEEAA---ARERAGRELQTAQAQLSE 1400

Query: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
                 +E+   L+   +A+      AEA  T + A+    +D  +   +  QQEL+  T 
Sbjct: 1401 WRRRQEEEAGALEAGEEARRRAAREAEAL-TQRLAEKTETVDRLERGRRRLQQELDDATM 1459

Query: 689  QLD---QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
             L+   Q+ + L+ KQ    QL   L E K   L   ++ E  E + ++ EA +L +  +
Sbjct: 1460 DLEQQRQLVSTLEKKQRKFDQL---LAEEKAAVLRAVEERERAEAEGREREARALSLTRA 1516

Query: 746  ---KEQALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
               +++A ++L++Q R L  +LE     LS + ++ K +    R   +   +A   ++ +
Sbjct: 1517 LEEEQEAREELERQNRALRAELE---ALLSSKDDVGKSVHELERA-CRVAEQAANDLRAQ 1572

Query: 802  LTKQEEE---KQILKQDFETLSQETKIQHE-ELNNRIQT-------TVTELQKVKMEKEA 850
            +T+ E+E    +  K   E   Q  K QHE +L  R +           +L+  ++E++ 
Sbjct: 1573 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1632

Query: 851  LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLK 910
               + +       K+   L+  K++     Q  + A+  L K   ++K +L  ++E T  
Sbjct: 1633 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK-ELWREVEETRT 1691

Query: 911  EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ---GNINELKQS 967
             ++E+     + ++    L+ E+  +QE+L  +    +Q +++  ++     N N  K +
Sbjct: 1692 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1751

Query: 968  SEQKKKQIEALQGELKIAVLQK---TELEN----KLQQQLTQAAQELAAEKEKISVLQNN 1020
              ++K+Q+E   G+L+  + ++   +EL N    KL  Q+     EL+AE+   +  ++ 
Sbjct: 1752 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1811

Query: 1021 YEKSQETFKQLQSDFYGRESELLAT-RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
             ++ +   ++L+      ++   A  +  + ++E KL+ A+E L     +     KL+  
Sbjct: 1812 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV-- 1869

Query: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
             + A+  L++   + E++ +     L+D  ++ +L+ K+L   K +L E EE   R +  
Sbjct: 1870 -RRAEKRLKEVVLQVEEE-RRVADQLRDQLEKGNLRVKQL---KRQLEEAEEEASRAQAG 1924

Query: 1140 ITKLNEELK--SHKLESI-KEITNLKD 1163
              +L  EL+  +   ES+ +E+T L++
Sbjct: 1925 RRRLQRELEDVTESAESMNREVTTLRN 1951



 Score =  164 bits (414), Expect = 7e-40
 Identities = 200/961 (20%), Positives = 408/961 (42%), Gaps = 111/961 (11%)

Query: 91   EVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDG----------LVTDSSAELQS 139
            E  +LQ  + E++  +EEL+ +L  K + LQ   A+ +            + ++ A L  
Sbjct: 1088 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1147

Query: 140  LEQQLEEAQTENFNI-KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
             ++ LE  +       KQ +DL E+  A L  E+ D     + ++ LR   EQ+VT L +
Sbjct: 1148 AQEDLESERVARTKAEKQRRDLGEELEA-LRGELEDTLDSTNAQQELRSKREQEVTELKK 1206

Query: 199  ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT---LMDNMTLERERESEKLKDEC 255
             L +E  + +    EL QR G + +  L ++L Q +      +   L  E E  +L+ E 
Sbjct: 1207 TLEEETRIHEAAVQELRQRHG-QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1265

Query: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
              LQ+     E    +L  +L    QEV     + ++ ++   E  Q+ Q   EN     
Sbjct: 1266 SSLQTARQEGEQRRRRLELQL----QEVQGRAGDGERARAEAAEKLQRAQAELEN----- 1316

Query: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375
                               +   L++ +    +L   LS++E  LH     L E+  A  
Sbjct: 1317 -------------------VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKL 1357

Query: 376  KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
             L   +  +E +   L+   +QL+++   +E+ G +LQ+   QL       E + G    
Sbjct: 1358 ALGSRVRAMEAEAAGLR---EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1414

Query: 436  RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
              + +R+ + E                    E L +++   TE   +L++ +++ Q++  
Sbjct: 1415 GEEARRRAAREA-------------------EALTQRLAEKTETVDRLERGRRRLQQE-- 1453

Query: 496  LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
                    L +A  DLEQ  + +   ++K +  + LL + K  +    +ERE   A+ + 
Sbjct: 1454 --------LDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1505

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             E     L +  E+    +E++ +    L+ + E+   +++++   V E +   R A+  
Sbjct: 1506 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1565

Query: 616  VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
               L   V EL  +L  +++          AK  L ++ +A KT    DLQ   +  +  
Sbjct: 1566 ANDLRAQVTELEDELTAAED----------AKLRLEVTVQALKTQHERDLQGRDEAGEER 1615

Query: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
             +   ++L     + D+   +         +LE  L+E K +  S  Q  EE   Q++K+
Sbjct: 1616 RRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKM 1675

Query: 736  EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ-LEMEKEIVSSTRLDLQKKSE- 793
            +A   E+    E+     ++    N + E R   L  + L +++E+ +S R   Q + + 
Sbjct: 1676 QAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1735

Query: 794  ---ALESIKQKLTKQE--EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848
               A E     L+K    EEK+ L+     L +E  ++ E+ N+ +       +K+ ++ 
Sbjct: 1736 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE--LEEEQSNSELLND--RYRKLLLQV 1791

Query: 849  EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ-MEN 907
            E+L TELS  +   +K     ++ + + E++ Q+ +  + + E      +H++ +  +E+
Sbjct: 1792 ESLTTELSAERSFSAKA----ESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALES 1846

Query: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
             L + +E  +   +E+  S +L   +   +++L +    +++  +   QL+  + +    
Sbjct: 1847 KLAQAEEQLEQETRERILSGKL---VRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1903

Query: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
             +Q K+Q+E  + E   A   +     +LQ++L    +   +   +++ L+N   +   T
Sbjct: 1904 VKQLKRQLEEAEEEASRAQAGR----RRLQRELEDVTESAESMNREVTTLRNRLRRGPLT 1959

Query: 1028 F 1028
            F
Sbjct: 1960 F 1960



 Score =  150 bits (378), Expect = 1e-35
 Identities = 211/1027 (20%), Positives = 450/1027 (43%), Gaps = 163/1027 (15%)

Query: 438  KEQRQLSSEKLMDKEQQVADLQLKLS-----RLEEQLKE--KVTNSTELQHQLDKTKQQH 490
            K Q+Q S+ ++M   Q+     LKL      RL  ++K   +VT   E+   L    Q+ 
Sbjct: 833  KRQQQQSALRVM---QRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEV---LQARAQEL 886

Query: 491  QEQQALQQSTTAKLREAQN---DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
            Q+ Q LQQ +  ++ E Q     LE+   ++ ++ +    L A  ++++  ++  ++E E
Sbjct: 887  QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELE 946

Query: 548  DLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
             + ++++A  GE    + Q+Q +   LQ+ + +L        E+H +A+E    ++Q +K
Sbjct: 947  LVVSELEARVGEEEECSRQMQTEKKRLQQHIQEL--------EAHLEAEEGARQKLQLEK 998

Query: 607  ----AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
                A ++  ++ +L LE   ++L+ +    ++++++   Q   + E + S    +    
Sbjct: 999  VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1058

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK----QEHCSQLESHLKEYKEKY 718
            A + +  D  +   +  +QEL K+  +LD  +++LQ++    Q+   +L + L   +E+ 
Sbjct: 1059 ATIADMEDRLRKE-EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEEL 1117

Query: 719  LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
             +   + E+  G   +L     E +A+  +A +DL+ +R   T  E +  +L ++LE   
Sbjct: 1118 QAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE--- 1174

Query: 779  EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH---EELNNRIQ 835
                + R +L+   ++  + ++  +K+E+E   LK   +TL +ET+I     +EL  R  
Sbjct: 1175 ----ALRGELEDTLDSTNAQQELRSKREQEVTELK---KTLEEETRIHEAAVQELRQRHG 1227

Query: 836  TTVTEL--------------QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
              + EL              +K ++  EA ++EL      L       +  +   E + Q
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287

Query: 882  KGKAAILDLEKTCKELKHQL---QVQMEN-----------TLKEQKELKKS--------- 918
            + +    D E+   E   +L   Q ++EN           T++  KEL  +         
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1347

Query: 919  -LEKEKEAS-------HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
             L++E  A          ++ E   ++EQL +     ++  +E Q  Q  ++E ++  E+
Sbjct: 1348 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1407

Query: 971  KKKQIEALQGELKIA----------VLQKTEL-------ENKLQQQLTQAAQELAAEKEK 1013
            +   +EA +   + A          + +KTE          +LQQ+L  A  +L  +++ 
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL 1467

Query: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK----------LSLAQEDL 1063
            +S L    EK Q  F QL ++    ++ +L   ++ +  E +          L+ A E+ 
Sbjct: 1468 VSTL----EKKQRKFDQLLAE---EKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1520

Query: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK----ALQDIQKEKSLKEKEL 1119
               R ++  QN+ ++    A  + + D  K   +L+  C+    A  D++ + +  E EL
Sbjct: 1521 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580

Query: 1120 -VNEKSKL---AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-------KDAKQLL 1168
               E +KL     ++ +K + E+++   +E  +  + +  K++ +        +  + L 
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640

Query: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228
            +  + +L+G+ + LKA +    + ++    Q++K + ++K+ + E E    S  +E+   
Sbjct: 1641 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS--REEIFS 1698

Query: 1229 MKKHEENEAK-LTMQITALNENLGTVKKEWQSSQRRVSELE--------------KQTDD 1273
              +  E   K L  ++  L E L    +  + +Q+   E+               ++   
Sbjct: 1699 QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ 1758

Query: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
            L G +  LE  ++  Q     L +R  K   ++E L T++       + + +A  E GR+
Sbjct: 1759 LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTEL-----SAERSFSAKAESGRQ 1813

Query: 1334 NQSLQIK 1340
                QI+
Sbjct: 1814 QLERQIQ 1820



 Score =  131 bits (329), Expect = 5e-30
 Identities = 162/814 (19%), Positives = 370/814 (45%), Gaps = 94/814 (11%)

Query: 90   QEVQDLQASLKEEKWYSEELKKELEKYQG------LQQQEAKPDGLVTDSSAELQSLEQQ 143
            QEV +L+ +L+EE    E   +EL +  G       +Q E    G        L +LE +
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL-ALEAE 1257

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY-DEERSLREAAEQKVTRLTEELNK 202
            + E + E  +++  +   EQ+  +L  ++ +++ +  D ER+  EAAE K+ R   EL  
Sbjct: 1258 VSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE-KLQRAQAELEN 1316

Query: 203  EATVIQDLKTELLQ--------RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
             +  + + +++ ++           + D   L +E  + +  + +     E E+  L+++
Sbjct: 1317 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ 1376

Query: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
             ++  +    +   +   +++L++  +        L+  + +     ++ + LT+ L +K
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436

Query: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
             +   +LE         ++ +Q  L    +D +Q +  +S  E    +    L+E+  A 
Sbjct: 1437 TETVDRLER-------GRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK---LLETERQLG 431
             +  EE    E + +  +A    L +  EE+++   +L+ +   L ++   LL ++  +G
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1549

Query: 432  EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE-QLKEKVT-NSTELQHQLDKTKQQ 489
            ++   L+   +++ +   D   QV +L+ +L+  E+ +L+ +VT  + + QH+ D   + 
Sbjct: 1550 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1609

Query: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
               ++  +Q    +LR+A+ +         D+++K + L    +K       LE E E+L
Sbjct: 1610 EAGEERRRQ-LAKQLRDAEVE--------RDEERKQRTLAVAARKK------LEGELEEL 1654

Query: 550  YAKI-QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
             A++  AG+G+   + QL++    +Q Q+ +L  ++    E  + ++E +  Q +E +  
Sbjct: 1655 KAQMASAGQGKEEAVKQLRK----MQAQMKELWREV----EETRTSREEIFSQNRESEKR 1706

Query: 609  LRAAQDRVLSLETSV---NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
            L+  +  VL L+  +   +    Q  + +++++            +L  +     +   L
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1766

Query: 666  QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
            +  L+  Q+  +       K+  Q++ +T +L  ++   ++ ES  ++       LE++ 
Sbjct: 1767 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ-------LERQI 1819

Query: 726  EELEGQI----------KKLEADSLEVK-ASKEQALQDLQQQRQLNTDL----ELRATEL 770
            +EL G++           K+   +LE K A  E+ L+   ++R L+  L    E R  E+
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1879

Query: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE-------KQILKQDFETLSQET 823
              Q+E E+ +    R  L+K +  ++ +K++L + EEE       ++ L+++ E +++  
Sbjct: 1880 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1939

Query: 824  KIQHEE---LNNRIQ------TTVTELQKVKMEK 848
            +  + E   L NR++      TT T  Q  ++E+
Sbjct: 1940 ESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1973



 Score =  124 bits (312), Expect = 5e-28
 Identities = 161/730 (22%), Positives = 326/730 (44%), Gaps = 77/730 (10%)

Query: 642  IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
            +Q+  + E+L  A A +  +  +LQ         LQ +  +L +   +L +   +L+ + 
Sbjct: 870  LQVTRQDEVL-QARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAE---QLRAEA 925

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E C++ E        +   LE    ELE ++ + E  S +++  K++  Q +Q+      
Sbjct: 926  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE-----L 980

Query: 762  DLELRATELSKQ-LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
            +  L A E ++Q L++EK    +T   ++K  E L  ++ + +K  +E+++L+      S
Sbjct: 981  EAHLEAEEGARQKLQLEKV---TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFS 1037

Query: 821  QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
             +   + E+        V  L K++++ EA + ++     K  K    L+  K   + E+
Sbjct: 1038 SQAAEEEEK--------VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089

Query: 881  QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL---EKEKEASHQLKLELNSMQ 937
             + +  +++ ++  +EL+ QL        ++++EL+ +L   E E  A  QL   L   Q
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLG-------RKEEELQAALARAEDEGGARAQLLKSLREAQ 1142

Query: 938  EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
              L +AQ  L+       + +    +L +       ++EAL+GEL+   L  T  + +L+
Sbjct: 1143 AALAEAQEDLESERVARTKAEKQRRDLGE-------ELEALRGELE-DTLDSTNAQQELR 1194

Query: 998  QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS 1057
             +  Q   EL    E+ + +   +E + +  +Q      G  +E L   +  K   EK  
Sbjct: 1195 SKREQEVTELKKTLEEETRI---HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR 1251

Query: 1058 LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
            LA E       ++      +  L+TA+   EQ   + E QLQE      D ++ ++   +
Sbjct: 1252 LALEA------EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1305

Query: 1118 ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ---KLE 1174
            +L   +++L  +       E +  +L++EL S + +       L DA++LL ++   KL 
Sbjct: 1306 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ-------LHDAQELLQEETRAKLA 1358

Query: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG-MKKHE 1233
            L  +  +++A  E     +Q+ ++   +E    + +  + +       +E+E G ++  E
Sbjct: 1359 LGSRVRAMEA--EAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1416

Query: 1234 ENEAKLTMQITALNENLG----TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
            E   +   +  AL + L     TV +  +  +R   EL+  T DL  +   L +T++  Q
Sbjct: 1417 EARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ-RQLVSTLEKKQ 1475

Query: 1290 --------DERRALL---ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
                    +E+ A+L   E   + E E  + + + L L R L+    A +EL R+N++L+
Sbjct: 1476 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1535

Query: 1339 IKHTQALNRK 1348
             +    L+ K
Sbjct: 1536 AELEALLSSK 1545



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 105/501 (20%), Positives = 232/501 (46%), Gaps = 53/501 (10%)

Query: 896  ELKHQLQVQMENTLKEQK--ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
            ++K  LQV  ++ + + +  EL+K  E +++++ ++  EL     QL + +  L +  + 
Sbjct: 865  KVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVG-ELQGRVAQLEEERARLAEQLRA 923

Query: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL-------ENKLQQQLTQAAQE 1006
            E +L     E +     +K+++E +  EL+  V ++ E        + +LQQ + +    
Sbjct: 924  EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983

Query: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
            L AE+     LQ     ++   K+ + D    E +     ++ K +E++L+         
Sbjct: 984  LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1043

Query: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
              ++ + NKL  + +   A +E    K+E+  QE  K  + +  E S  ++++V ++ + 
Sbjct: 1044 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1103

Query: 1127 AEIEEIKCRQEKE-----------------ITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
             E+     R+E+E                 + K   E ++   E+ +++ + + A+    
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1163

Query: 1170 QQKLELQGKADSLKAAVE---QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
            +Q+ +L  + ++L+  +E        QQ L+ + ++E  ELKK  +E+E ++H E   +E
Sbjct: 1164 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT-LEEETRIH-EAAVQE 1221

Query: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
            +  ++H +   +L  Q+       G     W+ ++     LE +  +LR E++ L+ T +
Sbjct: 1222 L-RQRHGQALGELAEQLEQARRGKGA----WEKTR---LALEAEVSELRAELSSLQ-TAR 1272

Query: 1287 NNQDERRALLERCLK------GEGEIEKLQT--KVLELQRKLDNTTAAVQELGRENQSLQ 1338
               ++RR  LE  L+      G+GE  + +   K+   Q +L+N + A+ E     +S  
Sbjct: 1273 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEA----ESKT 1328

Query: 1339 IKHTQALNRKWAEDNEVQNCM 1359
            I+ ++ L+   A+ ++ Q  +
Sbjct: 1329 IRLSKELSSTEAQLHDAQELL 1349



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 53/264 (20%), Positives = 119/264 (45%), Gaps = 36/264 (13%)

Query: 48   KSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSE 107
            + L ++D   +  +   D   D    G  + A   ++   L   +  L+  L+EE+  SE
Sbjct: 1719 EELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSE 1778

Query: 108  ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
             L    ++Y+ L  Q    + L T+ SAE +S   + E  +      +Q++   ++   +
Sbjct: 1779 LLN---DRYRKLLLQV---ESLTTELSAE-RSFSAKAESGR------QQLERQIQELRGR 1825

Query: 168  LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK 227
            L  E A  ++++   +    A E K+ +  E+L +E T  + L  +L++R        LK
Sbjct: 1826 LGEEDAGARARH---KMTIAALESKLAQAEEQLEQE-TRERILSGKLVRRAEKR----LK 1877

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            + ++QV+        E  R +++L+D+ +K           + QL+ +L +  +E +   
Sbjct: 1878 EVVLQVE--------EERRVADQLRDQLEK-------GNLRVKQLKRQLEEAEEEASRAQ 1922

Query: 288  QELQKLKSSVNELTQKNQTLTENL 311
               ++L+  + ++T+  +++   +
Sbjct: 1923 AGRRRLQRELEDVTESAESMNREV 1946


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  197 bits (501), Expect = 6e-50
 Identities = 236/1146 (20%), Positives = 507/1146 (44%), Gaps = 97/1146 (8%)

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            K L+QV T  D +   R +E +K+++  ++   +    +  ++QL  E A+  +++    
Sbjct: 859  KPLLQV-TRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 917

Query: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
            +   + + +   L  + Q L       E   ++LE +  EE    + +Q    +     Q
Sbjct: 918  ELCAEAEETRGRLAARKQEL-------ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ 970

Query: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
            +L++ L A E +  ++ +E        +K +E+L  +E +   L  E K L+ +  E   
Sbjct: 971  ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030

Query: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
               + + ++  L+   L+ E  + +   RL+++ +   E     E+    L  + S L+E
Sbjct: 1031 QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE----LEKLKRRLDGESSELQE 1086

Query: 468  QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
            Q+ E+   + EL+ QL + +++        Q+  A+  +      Q+L+ + +    +  
Sbjct: 1087 QMVEQQQRAEELRAQLGRKEEE-------LQAALARAEDEGGARAQLLKSLREAQAALAE 1139

Query: 528  LEALLQKSKENISLLEKEREDLYAKIQAGEGETA----VLNQLQEKNHTLQEQVTQLTEK 583
             +  L+  +   +  EK+R DL  +++A  GE        N  QE     +++VT+L + 
Sbjct: 1140 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1199

Query: 584  LKNQS-----------ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN- 631
            L+ ++           + H QA   L +Q+++ +    A +   L+LE  V+EL ++L+ 
Sbjct: 1200 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1259

Query: 632  ------ESKEKVSQLDIQI-----KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
                  E +++  +L++Q+     +A       AEAA+  QRA  Q  L+    AL + +
Sbjct: 1260 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA--QAELENVSGALNEAE 1317

Query: 681  QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
             +  +++ +L    A+L D QE        L+E     L+L  +   +E +   L     
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQE-------LLQEETRAKLALGSRVRAMEAEAAGLREQLE 1370

Query: 741  EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
            E  A++E+A ++LQ  +   ++   R  E +  LE  +E         ++ +   E++ Q
Sbjct: 1371 EEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA-------RRRAAREAEALTQ 1423

Query: 801  KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
            +L ++ E    L++    L QE      +L  + Q  V+ L+K + + + L+ E     +
Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ-LVSTLEKKQRKFDQLLAE-----E 1477

Query: 861  KLSKVSDSLKNSKSEFEKENQKGKA-----AILDLEKTCKELKHQ---LQVQMENTLKEQ 912
            K + +    +  ++E E   ++ +A     A+ + ++  +EL+ Q   L+ ++E  L  +
Sbjct: 1478 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK 1537

Query: 913  KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972
             ++ KS+ + + A    +   N ++ Q+ + ++ L   E  + +L+  +  LK   E+  
Sbjct: 1538 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD- 1596

Query: 973  KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
                 LQG  +    ++ +L  +L+    +  +E       ++  +    + +E   Q+ 
Sbjct: 1597 -----LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1651

Query: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
            S   G+E  +   R+ +++  ++L    E+  ++R +I +QN+   E +     LE +  
Sbjct: 1652 SAGQGKEEAVKQLRK-MQAQMKELWREVEETRTSREEIFSQNR---ESEKRLKGLEAEVL 1707

Query: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
            + +++L    +A +  Q+++     E+ N     A I E K + E  + +L EEL+    
Sbjct: 1708 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE-- 1765

Query: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
            +S  E+ N +  K LL  + L  +  A+   +A  +  R Q  L+ Q+++    L +E  
Sbjct: 1766 QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ--LERQIQELRGRLGEEDA 1823

Query: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
               A+    I   E  + + EE   + T +     + +   +K  +    +V E  +  D
Sbjct: 1824 GARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD 1883

Query: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332
             LR ++       +      + L  +  + E E  + Q     LQR+L++ T + + + R
Sbjct: 1884 QLRDQL-------EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1936

Query: 1333 ENQSLQ 1338
            E  +L+
Sbjct: 1937 EVTTLR 1942



 Score =  178 bits (451), Expect = 4e-44
 Identities = 244/1181 (20%), Positives = 510/1181 (43%), Gaps = 144/1181 (12%)

Query: 123  EAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE 182
            + KP   VT     LQ+  Q+L++ Q             +Q++A+   E+    ++ +EE
Sbjct: 857  KVKPLLQVTRQDEVLQARAQELQKVQE-----------LQQQSAREVGELQGRVAQLEEE 905

Query: 183  RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
            R+          RL E+L  EA    +L  E  +  G   +A  K+EL  V + ++    
Sbjct: 906  RA----------RLAEQLRAEA----ELCAEAEETRG--RLAARKQELELVVSELEARVG 949

Query: 243  ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
            E E  S +++ E K+LQ      EA +     E  +G +         QKL        Q
Sbjct: 950  EEEECSRQMQTEKKRLQQHIQELEAHL-----EAEEGAR---------QKL--------Q 987

Query: 303  KNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
              +  TE  +KK E+D   LE+++++ S  +K ++  L +      + + ++ +      
Sbjct: 988  LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1047

Query: 362  RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421
            +    +++  +  +K ++   E+E   + L  E  +LQ+Q  E++Q   +L++++ +   
Sbjct: 1048 KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1107

Query: 422  KL---LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
            +L   L      G A  +L +  + +   L + ++ +   ++  ++ E+Q ++       
Sbjct: 1108 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1167

Query: 479  LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE----------QVLRQIGDKDQKIQNL 528
            L+ +L+ T      QQ L+     ++ E +  LE          Q LRQ     Q +  L
Sbjct: 1168 LRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ--RHGQALGEL 1225

Query: 529  EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
               L++++      EK R  L A++     E + L   +++    + ++    ++++ ++
Sbjct: 1226 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1285

Query: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV--SQLDIQIKA 646
               ++A+    +++Q  +A L      +   E+    L+ +L+ ++ ++  +Q  +Q + 
Sbjct: 1286 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1345

Query: 647  KTELLLSAEA-AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
            + +L L +   A  A+ A L+  L+    A +   +EL     QL +   + +++     
Sbjct: 1346 RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE 1405

Query: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
              E   +    +  +L Q+  E    + +LE     ++   + A  DL+QQRQL + LE 
Sbjct: 1406 AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEK 1465

Query: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEA----LESIKQKLTKQEEEKQILKQDFETLSQ 821
            +  +  + L  EK  V    ++ ++++EA     E+    LT+  EE+           Q
Sbjct: 1466 KQRKFDQLLAEEKAAVLRA-VEERERAEAEGREREARALSLTRALEEE-----------Q 1513

Query: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
            E + + E  N  ++  +  L   K +    + EL        + ++ L+   +E E E  
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573

Query: 882  KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
              + A L LE T + LK Q +  ++   +  +E ++ L K+       ++E +  ++Q  
Sbjct: 1574 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ---LRDAEVERDEERKQRT 1630

Query: 942  QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
             A    K+ E E ++L+  +    Q  E+  KQ+  +Q ++K               +L 
Sbjct: 1631 LAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK---------------ELW 1675

Query: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
            +  +E    +E+I      + +++E+ K+L+    G E+E+L  +++L + +     AQ+
Sbjct: 1676 REVEETRTSREEI------FSQNRESEKRLK----GLEAEVLRLQEELAASDRARRQAQQ 1725

Query: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE---RCKALQDIQKEKSLKEK- 1117
            D     +++ N N     +   K  LE    + E++L+E     + L D  ++  L+ + 
Sbjct: 1726 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1785

Query: 1118 ---ELVNEKSKLAEIEEIKCRQEKEITKLNEEL--------KSHKLESIKEITNLKDAKQ 1166
               EL  E+S  A+ E  + + E++I +L   L          HK+      + L  A++
Sbjct: 1786 LTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1845

Query: 1167 LLIQQKLE--LQGK--------ADSLKAAVEQEKRNQQILKDQVKK---EEEELKKEFIE 1213
             L Q+  E  L GK           +   VE+E+R    L+DQ++K     ++LK++  E
Sbjct: 1846 QLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEE 1905

Query: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
             E     E    + G ++ +     +T    ++N  + T++
Sbjct: 1906 AE----EEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1942



 Score =  171 bits (433), Expect = 5e-42
 Identities = 238/1107 (21%), Positives = 497/1107 (44%), Gaps = 93/1107 (8%)

Query: 111  KELEKYQGLQQQEAKPDGLVTDSSAELQS----LEQQLE-------EAQTENFNIKQMKD 159
            +EL+K Q LQQQ A+  G +    A+L+     L +QL        EA+     +   K 
Sbjct: 876  QELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ 935

Query: 160  LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK-----TEL 214
              E   ++L   + + +    + ++ ++  +Q +  L   L  E    Q L+     TE 
Sbjct: 936  ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 995

Query: 215  LQRPGIEDVAVLK---KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQ 271
              +   ED+ +L+    +L + + L+++   E   ++ + +++ K L       EATI+ 
Sbjct: 996  KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD 1055

Query: 272  LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
            +   L K  +      QEL+KLK     L  ++  L E +++++Q   + EE   +    
Sbjct: 1056 MEDRLRKEEKG----RQELEKLK---RRLDGESSELQEQMVEQQQ---RAEELRAQLGRK 1105

Query: 332  KKNIQATLHQKDLD---CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY 388
            ++ +QA L + + +     QL   L  ++ +L     +L  +  A  K +++  ++  + 
Sbjct: 1106 EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1165

Query: 389  QHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
            + L+ E +        +++   + + E+ +L  K LE E ++ EA   ++E RQ   + L
Sbjct: 1166 EALRGELEDTLDSTNAQQELRSKREQEVTEL-KKTLEEETRIHEA--AVQELRQRHGQAL 1222

Query: 449  MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
             +  +Q+   +      E+         +EL+ +L   +   QE +  ++    +L+E Q
Sbjct: 1223 GELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ 1282

Query: 509  NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
                   R   +  +K+Q  +A L    EN+S    E E    ++      T    QL +
Sbjct: 1283 GRAGDGERARAEAAEKLQRAQAEL----ENVSGALNEAESKTIRLSKELSSTEA--QLHD 1336

Query: 569  KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
                LQE+ T+    L ++  + +     L +Q++E+ A   A +     L+T+  +L+ 
Sbjct: 1337 AQELLQEE-TRAKLALGSRVRAMEAEAAGLREQLEEEAA---ARERAGRELQTAQAQLSE 1392

Query: 629  QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
                 +E+   L+   +A+      AEA  T + A+    +D  +   +  QQEL+  T 
Sbjct: 1393 WRRRQEEEAGALEAGEEARRRAAREAEAL-TQRLAEKTETVDRLERGRRRLQQELDDATM 1451

Query: 689  QLD---QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
             L+   Q+ + L+ KQ    QL   L E K   L   ++ E  E + ++ EA +L +  +
Sbjct: 1452 DLEQQRQLVSTLEKKQRKFDQL---LAEEKAAVLRAVEERERAEAEGREREARALSLTRA 1508

Query: 746  ---KEQALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
               +++A ++L++Q R L  +LE     LS + ++ K +    R   +   +A   ++ +
Sbjct: 1509 LEEEQEAREELERQNRALRAELE---ALLSSKDDVGKSVHELERA-CRVAEQAANDLRAQ 1564

Query: 802  LTKQEEE---KQILKQDFETLSQETKIQHE-ELNNRIQT-------TVTELQKVKMEKEA 850
            +T+ E+E    +  K   E   Q  K QHE +L  R +           +L+  ++E++ 
Sbjct: 1565 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1624

Query: 851  LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLK 910
               + +       K+   L+  K++     Q  + A+  L K   ++K +L  ++E T  
Sbjct: 1625 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMK-ELWREVEETRT 1683

Query: 911  EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ---GNINELKQS 967
             ++E+     + ++    L+ E+  +QE+L  +    +Q +++  ++     N N  K +
Sbjct: 1684 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1743

Query: 968  SEQKKKQIEALQGELKIAVLQK---TELEN----KLQQQLTQAAQELAAEKEKISVLQNN 1020
              ++K+Q+E   G+L+  + ++   +EL N    KL  Q+     EL+AE+   +  ++ 
Sbjct: 1744 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1803

Query: 1021 YEKSQETFKQLQSDFYGRESELLAT-RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079
             ++ +   ++L+      ++   A  +  + ++E KL+ A+E L     +     KL+  
Sbjct: 1804 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV-- 1861

Query: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
             + A+  L++   + E++ +     L+D  ++ +L+ K+L   K +L E EE   R +  
Sbjct: 1862 -RRAEKRLKEVVLQVEEE-RRVADQLRDQLEKGNLRVKQL---KRQLEEAEEEASRAQAG 1916

Query: 1140 ITKLNEELK--SHKLESI-KEITNLKD 1163
              +L  EL+  +   ES+ +E+T L++
Sbjct: 1917 RRRLQRELEDVTESAESMNREVTTLRN 1943



 Score =  164 bits (414), Expect = 7e-40
 Identities = 200/961 (20%), Positives = 408/961 (42%), Gaps = 111/961 (11%)

Query: 91   EVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDG----------LVTDSSAELQS 139
            E  +LQ  + E++  +EEL+ +L  K + LQ   A+ +            + ++ A L  
Sbjct: 1080 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1139

Query: 140  LEQQLEEAQTENFNI-KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
             ++ LE  +       KQ +DL E+  A L  E+ D     + ++ LR   EQ+VT L +
Sbjct: 1140 AQEDLESERVARTKAEKQRRDLGEELEA-LRGELEDTLDSTNAQQELRSKREQEVTELKK 1198

Query: 199  ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT---LMDNMTLERERESEKLKDEC 255
             L +E  + +    EL QR G + +  L ++L Q +      +   L  E E  +L+ E 
Sbjct: 1199 TLEEETRIHEAAVQELRQRHG-QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAEL 1257

Query: 256  KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
              LQ+     E    +L  +L    QEV     + ++ ++   E  Q+ Q   EN     
Sbjct: 1258 SSLQTARQEGEQRRRRLELQL----QEVQGRAGDGERARAEAAEKLQRAQAELEN----- 1308

Query: 316  QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ 375
                               +   L++ +    +L   LS++E  LH     L E+  A  
Sbjct: 1309 -------------------VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKL 1349

Query: 376  KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
             L   +  +E +   L+   +QL+++   +E+ G +LQ+   QL       E + G    
Sbjct: 1350 ALGSRVRAMEAEAAGLR---EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1406

Query: 436  RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
              + +R+ + E                    E L +++   TE   +L++ +++ Q++  
Sbjct: 1407 GEEARRRAAREA-------------------EALTQRLAEKTETVDRLERGRRRLQQE-- 1445

Query: 496  LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
                    L +A  DLEQ  + +   ++K +  + LL + K  +    +ERE   A+ + 
Sbjct: 1446 --------LDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRE 1497

Query: 556  GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
             E     L +  E+    +E++ +    L+ + E+   +++++   V E +   R A+  
Sbjct: 1498 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1557

Query: 616  VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
               L   V EL  +L  +++          AK  L ++ +A KT    DLQ   +  +  
Sbjct: 1558 ANDLRAQVTELEDELTAAED----------AKLRLEVTVQALKTQHERDLQGRDEAGEER 1607

Query: 676  LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
             +   ++L     + D+   +         +LE  L+E K +  S  Q  EE   Q++K+
Sbjct: 1608 RRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKM 1667

Query: 736  EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ-LEMEKEIVSSTRLDLQKKSE- 793
            +A   E+    E+     ++    N + E R   L  + L +++E+ +S R   Q + + 
Sbjct: 1668 QAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR 1727

Query: 794  ---ALESIKQKLTKQE--EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848
               A E     L+K    EEK+ L+     L +E  ++ E+ N+ +       +K+ ++ 
Sbjct: 1728 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEE--LEEEQSNSELLND--RYRKLLLQV 1783

Query: 849  EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ-MEN 907
            E+L TELS  +   +K     ++ + + E++ Q+ +  + + E      +H++ +  +E+
Sbjct: 1784 ESLTTELSAERSFSAKA----ESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALES 1838

Query: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
             L + +E  +   +E+  S +L   +   +++L +    +++  +   QL+  + +    
Sbjct: 1839 KLAQAEEQLEQETRERILSGKL---VRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1895

Query: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
             +Q K+Q+E  + E   A   +     +LQ++L    +   +   +++ L+N   +   T
Sbjct: 1896 VKQLKRQLEEAEEEASRAQAGR----RRLQRELEDVTESAESMNREVTTLRNRLRRGPLT 1951

Query: 1028 F 1028
            F
Sbjct: 1952 F 1952



 Score =  150 bits (378), Expect = 1e-35
 Identities = 211/1027 (20%), Positives = 450/1027 (43%), Gaps = 163/1027 (15%)

Query: 438  KEQRQLSSEKLMDKEQQVADLQLKLS-----RLEEQLKE--KVTNSTELQHQLDKTKQQH 490
            K Q+Q S+ ++M   Q+     LKL      RL  ++K   +VT   E+   L    Q+ 
Sbjct: 825  KRQQQQSALRVM---QRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEV---LQARAQEL 878

Query: 491  QEQQALQQSTTAKLREAQN---DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
            Q+ Q LQQ +  ++ E Q     LE+   ++ ++ +    L A  ++++  ++  ++E E
Sbjct: 879  QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELE 938

Query: 548  DLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
             + ++++A  GE    + Q+Q +   LQ+ + +L        E+H +A+E    ++Q +K
Sbjct: 939  LVVSELEARVGEEEECSRQMQTEKKRLQQHIQEL--------EAHLEAEEGARQKLQLEK 990

Query: 607  ----AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
                A ++  ++ +L LE   ++L+ +    ++++++   Q   + E + S    +    
Sbjct: 991  VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1050

Query: 663  ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK----QEHCSQLESHLKEYKEKY 718
            A + +  D  +   +  +QEL K+  +LD  +++LQ++    Q+   +L + L   +E+ 
Sbjct: 1051 ATIADMEDRLRKE-EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEEL 1109

Query: 719  LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
             +   + E+  G   +L     E +A+  +A +DL+ +R   T  E +  +L ++LE   
Sbjct: 1110 QAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELE--- 1166

Query: 779  EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH---EELNNRIQ 835
                + R +L+   ++  + ++  +K+E+E   LK   +TL +ET+I     +EL  R  
Sbjct: 1167 ----ALRGELEDTLDSTNAQQELRSKREQEVTELK---KTLEEETRIHEAAVQELRQRHG 1219

Query: 836  TTVTEL--------------QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
              + EL              +K ++  EA ++EL      L       +  +   E + Q
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279

Query: 882  KGKAAILDLEKTCKELKHQL---QVQMEN-----------TLKEQKELKKS--------- 918
            + +    D E+   E   +L   Q ++EN           T++  KEL  +         
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1339

Query: 919  -LEKEKEAS-------HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
             L++E  A          ++ E   ++EQL +     ++  +E Q  Q  ++E ++  E+
Sbjct: 1340 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEE 1399

Query: 971  KKKQIEALQGELKIA----------VLQKTEL-------ENKLQQQLTQAAQELAAEKEK 1013
            +   +EA +   + A          + +KTE          +LQQ+L  A  +L  +++ 
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL 1459

Query: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK----------LSLAQEDL 1063
            +S L    EK Q  F QL ++    ++ +L   ++ +  E +          L+ A E+ 
Sbjct: 1460 VSTL----EKKQRKFDQLLAE---EKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1512

Query: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK----ALQDIQKEKSLKEKEL 1119
               R ++  QN+ ++    A  + + D  K   +L+  C+    A  D++ + +  E EL
Sbjct: 1513 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572

Query: 1120 -VNEKSKL---AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-------KDAKQLL 1168
               E +KL     ++ +K + E+++   +E  +  + +  K++ +        +  + L 
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632

Query: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228
            +  + +L+G+ + LKA +    + ++    Q++K + ++K+ + E E    S  +E+   
Sbjct: 1633 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS--REEIFS 1690

Query: 1229 MKKHEENEAK-LTMQITALNENLGTVKKEWQSSQRRVSELE--------------KQTDD 1273
              +  E   K L  ++  L E L    +  + +Q+   E+               ++   
Sbjct: 1691 QNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ 1750

Query: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
            L G +  LE  ++  Q     L +R  K   ++E L T++       + + +A  E GR+
Sbjct: 1751 LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTEL-----SAERSFSAKAESGRQ 1805

Query: 1334 NQSLQIK 1340
                QI+
Sbjct: 1806 QLERQIQ 1812



 Score =  131 bits (329), Expect = 5e-30
 Identities = 162/814 (19%), Positives = 370/814 (45%), Gaps = 94/814 (11%)

Query: 90   QEVQDLQASLKEEKWYSEELKKELEKYQG------LQQQEAKPDGLVTDSSAELQSLEQQ 143
            QEV +L+ +L+EE    E   +EL +  G       +Q E    G        L +LE +
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRL-ALEAE 1249

Query: 144  LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY-DEERSLREAAEQKVTRLTEELNK 202
            + E + E  +++  +   EQ+  +L  ++ +++ +  D ER+  EAAE K+ R   EL  
Sbjct: 1250 VSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE-KLQRAQAELEN 1308

Query: 203  EATVIQDLKTELLQ--------RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
             +  + + +++ ++           + D   L +E  + +  + +     E E+  L+++
Sbjct: 1309 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ 1368

Query: 255  CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
             ++  +    +   +   +++L++  +        L+  + +     ++ + LT+ L +K
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428

Query: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
             +   +LE         ++ +Q  L    +D +Q +  +S  E    +    L+E+  A 
Sbjct: 1429 TETVDRLER-------GRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481

Query: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK---LLETERQLG 431
             +  EE    E + +  +A    L +  EE+++   +L+ +   L ++   LL ++  +G
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1541

Query: 432  EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE-QLKEKVT-NSTELQHQLDKTKQQ 489
            ++   L+   +++ +   D   QV +L+ +L+  E+ +L+ +VT  + + QH+ D   + 
Sbjct: 1542 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1601

Query: 490  HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
               ++  +Q    +LR+A+ +         D+++K + L    +K       LE E E+L
Sbjct: 1602 EAGEERRRQ-LAKQLRDAEVE--------RDEERKQRTLAVAARKK------LEGELEEL 1646

Query: 550  YAKI-QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
             A++  AG+G+   + QL++    +Q Q+ +L  ++    E  + ++E +  Q +E +  
Sbjct: 1647 KAQMASAGQGKEEAVKQLRK----MQAQMKELWREV----EETRTSREEIFSQNRESEKR 1698

Query: 609  LRAAQDRVLSLETSV---NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
            L+  +  VL L+  +   +    Q  + +++++            +L  +     +   L
Sbjct: 1699 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1758

Query: 666  QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
            +  L+  Q+  +       K+  Q++ +T +L  ++   ++ ES  ++       LE++ 
Sbjct: 1759 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ-------LERQI 1811

Query: 726  EELEGQI----------KKLEADSLEVK-ASKEQALQDLQQQRQLNTDL----ELRATEL 770
            +EL G++           K+   +LE K A  E+ L+   ++R L+  L    E R  E+
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1871

Query: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE-------KQILKQDFETLSQET 823
              Q+E E+ +    R  L+K +  ++ +K++L + EEE       ++ L+++ E +++  
Sbjct: 1872 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1931

Query: 824  KIQHEE---LNNRIQ------TTVTELQKVKMEK 848
            +  + E   L NR++      TT T  Q  ++E+
Sbjct: 1932 ESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1965



 Score =  124 bits (312), Expect = 5e-28
 Identities = 161/730 (22%), Positives = 326/730 (44%), Gaps = 77/730 (10%)

Query: 642  IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
            +Q+  + E+L  A A +  +  +LQ         LQ +  +L +   +L +   +L+ + 
Sbjct: 862  LQVTRQDEVL-QARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAE---QLRAEA 917

Query: 702  EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT 761
            E C++ E        +   LE    ELE ++ + E  S +++  K++  Q +Q+      
Sbjct: 918  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE-----L 972

Query: 762  DLELRATELSKQ-LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
            +  L A E ++Q L++EK    +T   ++K  E L  ++ + +K  +E+++L+      S
Sbjct: 973  EAHLEAEEGARQKLQLEKV---TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFS 1029

Query: 821  QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
             +   + E+        V  L K++++ EA + ++     K  K    L+  K   + E+
Sbjct: 1030 SQAAEEEEK--------VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081

Query: 881  QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL---EKEKEASHQLKLELNSMQ 937
             + +  +++ ++  +EL+ QL        ++++EL+ +L   E E  A  QL   L   Q
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLG-------RKEEELQAALARAEDEGGARAQLLKSLREAQ 1134

Query: 938  EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
              L +AQ  L+       + +    +L +       ++EAL+GEL+   L  T  + +L+
Sbjct: 1135 AALAEAQEDLESERVARTKAEKQRRDLGE-------ELEALRGELE-DTLDSTNAQQELR 1186

Query: 998  QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS 1057
             +  Q   EL    E+ + +   +E + +  +Q      G  +E L   +  K   EK  
Sbjct: 1187 SKREQEVTELKKTLEEETRI---HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR 1243

Query: 1058 LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
            LA E       ++      +  L+TA+   EQ   + E QLQE      D ++ ++   +
Sbjct: 1244 LALEA------EVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1297

Query: 1118 ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ---KLE 1174
            +L   +++L  +       E +  +L++EL S + +       L DA++LL ++   KL 
Sbjct: 1298 KLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ-------LHDAQELLQEETRAKLA 1350

Query: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG-MKKHE 1233
            L  +  +++A  E     +Q+ ++   +E    + +  + +       +E+E G ++  E
Sbjct: 1351 LGSRVRAMEA--EAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1408

Query: 1234 ENEAKLTMQITALNENLG----TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
            E   +   +  AL + L     TV +  +  +R   EL+  T DL  +   L +T++  Q
Sbjct: 1409 EARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ-RQLVSTLEKKQ 1467

Query: 1290 --------DERRALL---ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
                    +E+ A+L   E   + E E  + + + L L R L+    A +EL R+N++L+
Sbjct: 1468 RKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALR 1527

Query: 1339 IKHTQALNRK 1348
             +    L+ K
Sbjct: 1528 AELEALLSSK 1537



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 105/501 (20%), Positives = 232/501 (46%), Gaps = 53/501 (10%)

Query: 896  ELKHQLQVQMENTLKEQK--ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
            ++K  LQV  ++ + + +  EL+K  E +++++ ++  EL     QL + +  L +  + 
Sbjct: 857  KVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVG-ELQGRVAQLEEERARLAEQLRA 915

Query: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL-------ENKLQQQLTQAAQE 1006
            E +L     E +     +K+++E +  EL+  V ++ E        + +LQQ + +    
Sbjct: 916  EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975

Query: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
            L AE+     LQ     ++   K+ + D    E +     ++ K +E++L+         
Sbjct: 976  LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1035

Query: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
              ++ + NKL  + +   A +E    K+E+  QE  K  + +  E S  ++++V ++ + 
Sbjct: 1036 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1095

Query: 1127 AEIEEIKCRQEKE-----------------ITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
             E+     R+E+E                 + K   E ++   E+ +++ + + A+    
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1155

Query: 1170 QQKLELQGKADSLKAAVE---QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
            +Q+ +L  + ++L+  +E        QQ L+ + ++E  ELKK  +E+E ++H E   +E
Sbjct: 1156 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT-LEEETRIH-EAAVQE 1213

Query: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
            +  ++H +   +L  Q+       G     W+ ++     LE +  +LR E++ L+ T +
Sbjct: 1214 L-RQRHGQALGELAEQLEQARRGKGA----WEKTR---LALEAEVSELRAELSSLQ-TAR 1264

Query: 1287 NNQDERRALLERCLK------GEGEIEKLQT--KVLELQRKLDNTTAAVQELGRENQSLQ 1338
               ++RR  LE  L+      G+GE  + +   K+   Q +L+N + A+ E     +S  
Sbjct: 1265 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEA----ESKT 1320

Query: 1339 IKHTQALNRKWAEDNEVQNCM 1359
            I+ ++ L+   A+ ++ Q  +
Sbjct: 1321 IRLSKELSSTEAQLHDAQELL 1341



 Score = 37.4 bits (85), Expect = 0.10
 Identities = 53/264 (20%), Positives = 119/264 (45%), Gaps = 36/264 (13%)

Query: 48   KSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSE 107
            + L ++D   +  +   D   D    G  + A   ++   L   +  L+  L+EE+  SE
Sbjct: 1711 EELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSE 1770

Query: 108  ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
             L    ++Y+ L  Q    + L T+ SAE +S   + E  +      +Q++   ++   +
Sbjct: 1771 LLN---DRYRKLLLQV---ESLTTELSAE-RSFSAKAESGR------QQLERQIQELRGR 1817

Query: 168  LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK 227
            L  E A  ++++   +    A E K+ +  E+L +E T  + L  +L++R        LK
Sbjct: 1818 LGEEDAGARARH---KMTIAALESKLAQAEEQLEQE-TRERILSGKLVRRAEKR----LK 1869

Query: 228  KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
            + ++QV+        E  R +++L+D+ +K           + QL+ +L +  +E +   
Sbjct: 1870 EVVLQVE--------EERRVADQLRDQLEK-------GNLRVKQLKRQLEEAEEEASRAQ 1914

Query: 288  QELQKLKSSVNELTQKNQTLTENL 311
               ++L+  + ++T+  +++   +
Sbjct: 1915 AGRRRLQRELEDVTESAESMNREV 1938


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.304    0.121    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,930,918
Number of Sequences: 37866
Number of extensions: 2137150
Number of successful extensions: 70294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1085
Number of HSP's successfully gapped in prelim test: 1709
Number of HSP's that attempted gapping in prelim test: 12748
Number of HSP's gapped (non-prelim): 18486
length of query: 1411
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1296
effective length of database: 13,892,928
effective search space: 18005234688
effective search space used: 18005234688
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.