Search of human proteins with 55770850

Search of human proteins with 55770850

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
         (514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...  1041   0.0  
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1...   836   0.0  
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   262   6e-70
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   245   6e-65
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid...   222   6e-58
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   209   4e-54
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide...   207   2e-53
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid...   206   5e-53
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid...   164   2e-40
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide...   154   2e-37
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   144   1e-34
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   133   4e-31
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   129   5e-30
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   125   9e-29
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  119   7e-27
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   114   3e-25
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   113   4e-25
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   113   4e-25
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   113   4e-25
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   112   6e-25
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   112   8e-25
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   110   3e-24
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   109   7e-24
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   108   9e-24
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   106   4e-23
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   106   4e-23
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   106   6e-23
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        105   1e-22
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   105   1e-22
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   104   2e-22

>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 1041 bits (2692), Expect = 0.0
 Identities = 514/514 (100%), Positives = 514/514 (100%)

Query: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60
           MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
Sbjct: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120
           PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
Sbjct: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180
           TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
Sbjct: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

Query: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240
           EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
Sbjct: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240

Query: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300
           AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
Sbjct: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300

Query: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
           FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
Sbjct: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ 420
           PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
Sbjct: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ 420

Query: 421 VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV 480
           VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
Sbjct: 421 VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV 480

Query: 481 RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 514
           RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Sbjct: 481 RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 514


>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 448

 Score =  836 bits (2160), Expect = 0.0
 Identities = 418/441 (94%), Positives = 420/441 (95%)

Query: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60
           MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
Sbjct: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120
           PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
Sbjct: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180
           TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
Sbjct: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

Query: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240
           EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
Sbjct: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240

Query: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300
           AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
Sbjct: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300

Query: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
           FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
Sbjct: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ 420
           PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKG V   + Q
Sbjct: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQ 420

Query: 421 VLGSSEDNFEDSSQFRPERWL 441
              +       S    P R L
Sbjct: 421 ATDNEPVEMLHSGTLVPSREL 441



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 36/36 (100%), Positives = 36/36 (100%)

Query: 479 IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 514
           IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Sbjct: 413 IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 448


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  262 bits (669), Expect = 6e-70
 Identities = 158/476 (33%), Positives = 249/476 (52%), Gaps = 33/476 (6%)

Query: 65  PLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121
           P LG L    Q+  +G   + H   V Y  KYG ++   LG    V+L S  LLE + R 
Sbjct: 61  PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120

Query: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINE 181
           E  YP R +++ WK +RD     YG    EG  W ++R A  ++L+KP E     +  NE
Sbjct: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180

Query: 182 VLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNF 238
           V+ DFM R+D+L  E      V D+      ++ E+IC +L+EKR G LQ++  ++ V F
Sbjct: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240

Query: 239 IMAIKTMM-----STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293
           + +I  M      +TF      PV          W+ +   W+ IF   K  ID +LE  
Sbjct: 241 VRSIGLMFQNSLYATFLPKWTRPV-------LPFWKRYLDGWNAIFSFGKKLIDEKLEDM 293

Query: 294 SQQPSA---------DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
             Q  A          +L  +    +LS +E   ++ EL +A V+TT+N+L W LY+LS+
Sbjct: 294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSK 353

Query: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVL 404
           +P++Q+ L +E+  V+P  QVP+ +D  +MP LKA LKE++RL P VP  +R ++K   +
Sbjct: 354 DPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV 413

Query: 405 GEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKI-----NPFAHLPFGVGK 459
             +  PK T  +    V+      F +   F+P RWL+  +       +PF  +PFG G 
Sbjct: 414 DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGV 473

Query: 460 RMCIGRRLAELQLHLALCWIVRKYD-IQATDNEPVEMLHSGTLVPSRELPIAFCQR 514
           R C+GRR+AEL++ L L  +++KY  + A +   ++ +    LVP++++ + F QR
Sbjct: 474 RACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQR 529


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  245 bits (626), Expect = 6e-65
 Identities = 161/481 (33%), Positives = 238/481 (49%), Gaps = 26/481 (5%)

Query: 53  QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSP 112
           ++ A +PGP++   L  L     KGGL + H+  V+    +G ++    G+  +V++ +P
Sbjct: 35  RSLADIPGPSTPSFLAELF---CKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAP 91

Query: 113 CLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEV 172
            L+E L R E   P+R    PW  +R  R+   GLL  EGE+WQR+RS     L++P   
Sbjct: 92  ALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151

Query: 173 MKLDNKINEVLADFMGRIDELCDERGH-------VEDLYSELNKWSFESICLVLYEKRFG 225
            +    +N V+ D + R+     +RG        V D+  E  K+  E I  VL   R G
Sbjct: 152 ARYAGTLNNVVCDLVRRLRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 226 LLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
            L+     +   FI A+ ++  +    M  P  L + L    W      WD +F   +  
Sbjct: 209 CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRH 267

Query: 286 IDNRLEKYSQ----QPSADFLCDIYHQNRLSKKELYAA-----VTELQLAAVETTANSLM 336
           ++ R  + +     QP  D     +  + L ++EL A      VTEL LA V+T +N+L 
Sbjct: 268 VERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLS 327

Query: 337 WILYNLSRNPQVQQKLLKEIQSVLP--ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT 394
           W LY LSR+P+VQ  L  EI + L    +  P A  L  +P LKA +KE +RL P VP  
Sbjct: 328 WALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGN 387

Query: 395 TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLP 454
           +R  DK   +G+Y +PK T++ L           F + + FRP RWL E    +PFA LP
Sbjct: 388 SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLP 447

Query: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN-EPVEMLHSGTLVPSRELPIAFCQ 513
           FG GKR C+GRRLAEL+L +AL  I+  +++Q      PV       LVP R + + F  
Sbjct: 448 FGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLD 507

Query: 514 R 514
           R
Sbjct: 508 R 508


>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform a precursor [Homo sapiens]
          Length = 521

 Score =  222 bits (566), Expect = 6e-58
 Identities = 146/466 (31%), Positives = 235/466 (50%), Gaps = 13/466 (2%)

Query: 54  NAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPC 113
           N    PG   W    +L     + G  K H   V+  +KYG I+R KLG+ ESV++  P 
Sbjct: 49  NEIPSPGDNGWL---NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105

Query: 114 LLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVM 173
            +  L+++E   P+R  I PW AY  Y +   G+L+ +   W++ R A  +++M P    
Sbjct: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165

Query: 174 KLDNKINEVLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
                ++ V  DF+  +     + G   +  D+  +L +++FESI  V++ +R G+L++ 
Sbjct: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV 225

Query: 231 AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRL 290
              EA  FI AI  M  T   M+  P +L +   TK W+DH  AWD IF        N  
Sbjct: 226 VNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFY 285

Query: 291 EKYSQQPSA--DFLCDIYH---QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345
            +  Q+ S   D+   +Y     +++S +++ A VTE+    V+TT+ +L W LY ++RN
Sbjct: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345

Query: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLG 405
            +VQ  L  E+ +   + Q   A  L+ +P LKA +KE++RL P      R L    VL 
Sbjct: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405

Query: 406 EYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGR 465
           +Y +P  T++ +    LG     F D   F P RWL + + I  F +L FG G R C+GR
Sbjct: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGR 465

Query: 466 RLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511
           R+AEL++ + L  ++  + ++      V    +  L+P  E PI+F
Sbjct: 466 RIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMP--EKPISF 509


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  209 bits (533), Expect = 4e-54
 Identities = 124/374 (33%), Positives = 203/374 (54%), Gaps = 20/374 (5%)

Query: 158 VRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELN------KWS 211
           +RS  +++++KP +V     ++N+V+AD + RI  L   R   ED  +  N      K+S
Sbjct: 1   MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLL---RSQAEDGETVTNVNDLFFKYS 57

Query: 212 FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPV--ELHKSLNTKVWQ 269
            E +  +LYE R G L+ +     V +I A++ M S F   M         +    K W+
Sbjct: 58  MEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWR 117

Query: 270 DHTLAWDTIFKSVKACIDNRLEKYSQQP------SADFLCDIYHQNRLSKKELYAAVTEL 323
           +   +WD +FK  +  +DN+L     Q       S   L  ++    L+ +E+YA VTE+
Sbjct: 118 EFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEM 177

Query: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383
            LA V+TT+ +L W +Y L+R+P+VQQ + +EI   L E  VP A D+  +P ++A LKE
Sbjct: 178 LLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKE 237

Query: 384 SMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ- 442
           ++RL P +P   R   +  V+G Y +PKGT L L        ++NF  + +FRPERWL+ 
Sbjct: 238 TLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRK 297

Query: 443 -EKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQ-ATDNEPVEMLHSGT 500
            + ++++ F  +PFG G R CIGRR+AEL++HL +  +++ ++I+ ++    V     G 
Sbjct: 298 GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGL 357

Query: 501 LVPSRELPIAFCQR 514
           L P   + + F  R
Sbjct: 358 LTPGGPIHVRFVNR 371


>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 503

 Score =  207 bits (526), Expect = 2e-53
 Identities = 129/441 (29%), Positives = 221/441 (50%), Gaps = 6/441 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R     +++ P  V +    ++ V  DF   
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L +  + KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++     LS   + A   EL   +V+TT   L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLG 423
                +    +P L+A LKE++RL P   F  R      VL  Y +P GT++ +    LG
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411

Query: 424 SSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 483
            +   F    ++ P+RWL  +     F H+PFG G R C+GRRLAE ++ L L  +++  
Sbjct: 412 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471

Query: 484 DIQATDNEPVEMLHSGTLVPS 504
            ++    E ++M++S  L PS
Sbjct: 472 QVETLTQEDIKMVYSFILRPS 492


>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
           precursor [Homo sapiens]
          Length = 503

 Score =  206 bits (523), Expect = 5e-53
 Identities = 130/448 (29%), Positives = 227/448 (50%), Gaps = 6/448 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R      ++ P  V +    ++ V  DF   
Sbjct: 112 ILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L + ++ KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++  +  LS + + A   EL   +V+TTA  L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLG 423
                +    +P L+A LKE++RL P   F  R +    VL  Y +P GT++ +    LG
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLG 411

Query: 424 SSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 483
            +   F    ++ P+RWL  +     F H+PFG G R C+GRRLAE ++ L L  +++ +
Sbjct: 412 RNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471

Query: 484 DIQATDNEPVEMLHSGTLVPSRELPIAF 511
            ++    E ++M++S  L P     + F
Sbjct: 472 LVETLTQEDIKMVYSFILRPGTSPLLTF 499


>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform b [Homo sapiens]
          Length = 363

 Score =  164 bits (414), Expect = 2e-40
 Identities = 104/315 (33%), Positives = 165/315 (52%), Gaps = 7/315 (2%)

Query: 202 DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHK 261
           D+  +L +++FESI  V++ +R G+L++    EA  FI AI  M  T   M+  P +L +
Sbjct: 39  DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 98

Query: 262 SLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA--DFLCDIYH---QNRLSKKEL 316
              TK W+DH  AWD IF        N   +  Q+ S   D+   +Y     +++S +++
Sbjct: 99  LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 158

Query: 317 YAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPY 376
            A VTE+    V+TT+ +L W LY ++RN +VQ  L  E+ +   + Q   A  L+ +P 
Sbjct: 159 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 218

Query: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFR 436
           LKA +KE++RL P      R L    VL +Y +P  T++ +    LG     F D   F 
Sbjct: 219 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 278

Query: 437 PERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEML 496
           P RWL + + I  F +L FG G R C+GRR+AEL++ + L  ++  + ++      V   
Sbjct: 279 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 338

Query: 497 HSGTLVPSRELPIAF 511
            +  L+P  E PI+F
Sbjct: 339 FNLILMP--EKPISF 351


>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 437

 Score =  154 bits (388), Expect = 2e-37
 Identities = 104/374 (27%), Positives = 178/374 (47%), Gaps = 6/374 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R     +++ P  V +    ++ V  DF   
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L +  + KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++     LS   + A   EL   +V+TT   L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLG 423
                +    +P L+A LKE++RL P   F  R      VL  Y +P G +  L  + L 
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLT 411

Query: 424 SSEDNFEDSSQFRP 437
             +     S   RP
Sbjct: 412 QEDIKMVYSFILRP 425


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  144 bits (364), Expect = 1e-34
 Identities = 130/479 (27%), Positives = 222/479 (46%), Gaps = 57/479 (11%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  PLLG++L   Q LWK       DT  E +KKYGK++    G    + +  P +
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWK------FDT--ECYKKYGKMWGTYEGQLPVLAITDPDV 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPG 170
           +  +   E  S +  R  + P    +        + + E E+W+R+RS         K  
Sbjct: 90  IRTVLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E+  +  +  +VL   + R  E    +G    L      +S +    V+    FG+   +
Sbjct: 144 EMFPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMD----VITGTSFGVNIDS 195

Query: 231 AGDEAVNFIMAIKTMMSTFGRM-----------MVTPVELHKSLNTKVWQDHTLAWDTIF 279
             +    F+ + K  +  FG +            +TPV   ++LN  ++   T+ +  + 
Sbjct: 196 LNNPQDPFVESTKKFLK-FGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LS 250

Query: 280 KSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VET 330
           KSV     +RL    Q+   DFL  +       + E + A+++L+LAA          ET
Sbjct: 251 KSVNRMKKSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309

Query: 331 TANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPS 390
           T++ L + LY L+ +P VQQKL KEI +VLP    P  + +  M YL   + E++RL P 
Sbjct: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369

Query: 391 VPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPF 450
                RT  K   +    +PKG+++++ T  L      + +  +FRPER+ ++K+ I+P+
Sbjct: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429

Query: 451 AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSREL 507
            + PFG G R CIG R A + + LAL  +++ +  +       P+++   G L P + +
Sbjct: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPI 488


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  133 bits (334), Expect = 4e-31
 Identities = 112/457 (24%), Positives = 199/457 (43%), Gaps = 40/457 (8%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP   P LG+   +      ++ H  +  + KKYG +F ++LG   +V + G P + EA
Sbjct: 45  PGPWRLPFLGNFFLV----DFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEA 100

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LD 176
           L   +  +  R    P    R++  +  GL++  G+ W+  R      L   G   K L+
Sbjct: 101 LIHMDQNFGNR----PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 177 NKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD--- 233
            +I E        I E   E G   D + ++N      IC + + +RF            
Sbjct: 157 ERIQEEAQHLTEAIKE---ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLK 213

Query: 234 --EAVNFIMAIKT--MMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNR 289
             + V ++ A KT  + + F  +M      H++L +         W  +   V   ID  
Sbjct: 214 LLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSN--------WKKLKLFVSHMIDKH 265

Query: 290 LEKYSQQPSADFLCDIYHQ----------NRLSKKELYAAVTELQLAAVETTANSLMWIL 339
            + ++   + DF+ D Y +          +   ++ L  +  +L  A  ETT+ +L W L
Sbjct: 266 RKDWNPAETRDFI-DAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWAL 324

Query: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTL 398
             ++  P++Q+K+  EI  V+ + Q P      +MPY  A + E  R+   +P    R +
Sbjct: 325 LYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREV 384

Query: 399 DKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVG 458
              T L  Y LPKGT+++ N   L      +     F P+ +L+  +     A +PF +G
Sbjct: 385 TVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIG 444

Query: 459 KRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEM 495
           KR C+G +LA  +L +    +++K+  +  +NE + +
Sbjct: 445 KRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSL 481


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  129 bits (325), Expect = 5e-30
 Identities = 124/472 (26%), Positives = 214/472 (45%), Gaps = 46/472 (9%)

Query: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
           +PGPT  P LG++L    KG         +E HKKYGK++    G    + +  P +++ 
Sbjct: 38  IPGPTPLPFLGNILSY-HKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92

Query: 118 LYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEVM 173
           +   E  S +  R    P    +        + I E E+W+R+RS         K  E++
Sbjct: 93  VLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146

Query: 174 KLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD 233
            +  +  +VL   + R  E     G    L      +S +    V+    FG+   +  +
Sbjct: 147 PIIAQYGDVLVRNLRREAET----GKPVTLKDVFGAYSMD----VITSTSFGVNIDSLNN 198

Query: 234 EAVNFIMAIKTMMST------FGRMMVTP--VELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
               F+   K ++        F  + V P  + + + LN  V+      +  + KSVK  
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKRM 256

Query: 286 IDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VETTANSLM 336
            ++RLE  +Q+   DFL  +       + E + A+++L+L A          ETT++ L 
Sbjct: 257 KESRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 337 WILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396
           +I+Y L+ +P VQQKL +EI +VLP    P  + +  M YL   + E++RL P      R
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375

Query: 397 TLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKINPFAHLPF 455
              K   +    +PKG V+M+ +  L      + +  +F PER+ ++ K+ I+P+ + PF
Sbjct: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435

Query: 456 GVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSR 505
           G G R CIG R A + + LAL  +++ +  +       P+++   G L P +
Sbjct: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 487


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  125 bits (314), Expect = 9e-29
 Identities = 124/482 (25%), Positives = 218/482 (45%), Gaps = 62/482 (12%)

Query: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTL-VEYHKKYGKIFRMKLGSFESVHLGSPCLLE 116
           +PGPT  P LG+ L        +K + T  +E +KKY K++ +       + +  P +++
Sbjct: 38  IPGPTPLPFLGNALSF------RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIK 91

Query: 117 ALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEV 172
            +   E  S +  R    P    ++       + I E E+W+R+RS         K  E+
Sbjct: 92  TVLVKECYSVFTNRRPFGPVGFMKN------AISIAEDEEWKRIRSLLSPTFTSGKLKEM 145

Query: 173 MKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLY------------ 220
           + +  +  +VL   + R  E     G    L      +S + I    +            
Sbjct: 146 VPIIAQYGDVLVRNLRREAET----GKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQD 201

Query: 221 ---EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDT 277
              E    LL+ N  D    F+++IK          +TP+   ++LN  V+    +++ T
Sbjct: 202 PFVENTKKLLRFNPLDP---FVLSIKVFP------FLTPIL--EALNITVFPRKVISFLT 250

Query: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAV 328
             KSVK   + RL K +Q+   DFL  +         E + A+++L+L         A  
Sbjct: 251 --KSVKQIKEGRL-KETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGY 307

Query: 329 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLT 388
           ETT++ L +I+Y L+ +P VQQK+ KEI +VLP    P  + +  + YL   + E++RL 
Sbjct: 308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLF 367

Query: 389 PSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKI 447
           P      R   K   +    +PKG V+M+ + VL      + +  +F PER+ ++ K+ I
Sbjct: 368 PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427

Query: 448 NPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSR 505
           +P+ + PFG G R CIG R A + + LAL  +++ +  +       P+++   G L+  +
Sbjct: 428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEK 487

Query: 506 EL 507
            +
Sbjct: 488 PI 489


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  119 bits (298), Expect = 7e-27
 Identities = 111/456 (24%), Positives = 205/456 (44%), Gaps = 46/456 (10%)

Query: 63  SWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLL-EALYRT 121
           S PL+GSL  +   G +   H+   +  KKYG I+ +++G+  +V +G   L  E L + 
Sbjct: 33  SLPLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKK 89

Query: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILE-GEDWQRVRSAFQKK--LMKPGEVMKLDNK 178
              +  R ++       + RK   G+   + G  WQ  R        L K G     D K
Sbjct: 90  GKDFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHRRLAMATFALFKDG-----DQK 141

Query: 179 INEVLADFMGRI-DELCDERGHVEDLYSELNKWSFESICLVLYEKRF------------- 224
           + +++   +  + D L    G   D+   +       I L+ +   +             
Sbjct: 142 LEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY 201

Query: 225 --GLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAW--DTIFK 280
             G++   + D  V+ +  +K   +     + + V++   L  K+ +++   +  D+I  
Sbjct: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN 261

Query: 281 SVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILY 340
            +   +  ++   +     D   ++     LS   +   + ++  A VETT + + W L 
Sbjct: 262 MLDTLMQAKMNSDNGNAGPDQDSEL-----LSDNHILTTIGDIFGAGVETTTSVVKWTLA 316

Query: 341 NLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDK 400
            L  NPQV++KL +EI   +  ++ P   D   +  L+A ++E +RL P  P       K
Sbjct: 317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP--HK 374

Query: 401 ATV---LGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE--KEKINP-FAHLP 454
           A V   +GE+A+ KGT +++N   L  +E  +    QF PER+L     + I+P  ++LP
Sbjct: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434

Query: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN 490
           FG G R CIG  LA  +L L + W+++++D++  D+
Sbjct: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  114 bits (284), Expect = 3e-25
 Identities = 118/448 (26%), Positives = 193/448 (43%), Gaps = 49/448 (10%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL 118
           PGP   PL+G+L  +     L +Q  +L+E  ++YG +F + LG  ++V L      EA+
Sbjct: 33  PGPRPLPLVGNLHLLR----LSQQDRSLMELSERYGPVFTVHLGRQKTVVLTG---FEAV 85

Query: 119 YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LDN 177
               +   Q L  +P  A     + G G+    G  W+  R    + L   G   + + +
Sbjct: 86  KEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVAD 145

Query: 178 KINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL-VLYEKRF-----------G 225
           KI + L    G++D     RG    L   L  W+  +I   +L+ +RF           G
Sbjct: 146 KILQELKCLSGQLDGY---RGRPFPL--ALLGWAPSNITFALLFGRRFDYRDPVFVSLLG 200

Query: 226 LLQK------NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNT--KVWQDHTLAWDT 277
           L+ +      + G +  N    +  ++     ++    E+   L T  +  + H    D 
Sbjct: 201 LIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDP 260

Query: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMW 337
           +   V A I        QQ   D       +   ++    A   ++ +A  ETT+ +L W
Sbjct: 261 VCSYVDALI--------QQGQGDD-----PEGLFAEANAVACTLDMVMAGTETTSATLQW 307

Query: 338 ILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397
               + R+P VQ ++ +E+  VL   + PR ED + +PY  A L E  R    +P   R 
Sbjct: 308 AALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRC 367

Query: 398 LDKATVLGEYALPKGT-VLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFAHLPF 455
               T LG + LPKGT V+ L T VL   E  ++   QF P  +L      +   A LPF
Sbjct: 368 TAADTQLGGFLLPKGTPVIPLLTSVL-LDETQWQTPGQFNPGHFLDANGHFVKREAFLPF 426

Query: 456 GVGKRMCIGRRLAELQLHLALCWIVRKY 483
             G+R+C+G RLA  +L L    ++++Y
Sbjct: 427 SAGRRVCVGERLARTELFLLFAGLLQRY 454


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  113 bits (283), Expect = 4e-25
 Identities = 103/448 (22%), Positives = 195/448 (43%), Gaps = 40/448 (8%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP   P++G+L Q+     LK    +     +++G +F + +GS   V + G   + EA
Sbjct: 34  PGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEA 89

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM-----KPGEV 172
           L   +  +  R ++  + A+RD      G++   G  W+ +R      L      K G  
Sbjct: 90  LLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNE 144

Query: 173 MKLDNKIN---EVLADFMGRIDEL-----CDERGHVEDL----YSELNKWSFESICLVLY 220
            ++  + +   E L    G+  +      C     + D+    + + N   F  + + L+
Sbjct: 145 SRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL-MYLF 203

Query: 221 EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFK 280
            + F LL         NF   +  +  +  +++    E+ + ++ +V + H        +
Sbjct: 204 NENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPR 263

Query: 281 SVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILY 340
            +  C+   +EK        +  D           +   V +L  A  ETT+ +L + L 
Sbjct: 264 DLTDCLLVEMEKEKHSAERLYTMD----------GITVTVADLFFAGTETTSTTLRYGLL 313

Query: 341 NLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT-TRTLD 399
            L + P++++KL +EI  V+  +++P  +D + MPY+ A + E  R    VP        
Sbjct: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373

Query: 400 KATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHL-PFGVG 458
           + T+   Y +PKGTV++     +      F D  +F+PE +L E  K     +  PF  G
Sbjct: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433

Query: 459 KRMCIGRRLAELQLHLALCWIVRKYDIQ 486
           KR+C G  LA ++L L LC I++ ++++
Sbjct: 434 KRVCAGEGLARMELFLLLCAILQHFNLK 461


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  113 bits (283), Expect = 4e-25
 Identities = 111/444 (25%), Positives = 200/444 (45%), Gaps = 57/444 (12%)

Query: 85  TLVEYHKKYGKIFRMKLG-SFESVHLGSPCLLEALYRTESAYPQRLEI-----KPWKAYR 138
           TL +    Y + F++ LG +F  + L  P ++  +    +A   +  I     KPW    
Sbjct: 76  TLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWL--- 132

Query: 139 DYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELC 194
                G GLL+  G+ W R R     AF   ++KP   MK+ NK   ++ D   R   L 
Sbjct: 133 -----GDGLLLSGGDKWSRHRRMLTPAFHFNILKP--YMKIFNKSVNIMHDKWQR---LA 182

Query: 195 DERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMV 254
            E     D++  ++  + +S+   ++       + N  ++   +I AI  + S F     
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFS-----FESNCQEKPSEYIAAILEL-SAFVEKRN 236

Query: 255 TPVELHKSLNTKVWQD-----------HTLAWDTIFKSVKAC-----IDNRLEKYSQQPS 298
             + LH      +  D           H    D + +  +       ID+ L+  ++  +
Sbjct: 237 QQILLHTDFLYYLTPDGQRFRRACHLVHDFT-DAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 299 ADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352
            DF+ D+   ++      LS +++ A          +TTA+ L W+LY+L+++P+ Q++ 
Sbjct: 296 LDFI-DVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQC 354

Query: 353 LKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YAL 409
            +E+Q +L + +    E  DL  +P+L  C+KES+RL P VP  +R   +  VL +   +
Sbjct: 355 RQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVI 414

Query: 410 PKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFAHLPFGVGKRMCIGRRLA 468
           PKG V ++N   +  +   + D   + P R+ QE  ++ +P A +PF  G R CIG+  A
Sbjct: 415 PKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFA 474

Query: 469 ELQLHLALCWIVRKYDIQATDNEP 492
             ++ + L   +  + I  T  EP
Sbjct: 475 MAEMKVVLALTLLHFRILPTHTEP 498


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  113 bits (283), Expect = 4e-25
 Identities = 111/444 (25%), Positives = 200/444 (45%), Gaps = 57/444 (12%)

Query: 85  TLVEYHKKYGKIFRMKLG-SFESVHLGSPCLLEALYRTESAYPQRLEI-----KPWKAYR 138
           TL +    Y + F++ LG +F  + L  P ++  +    +A   +  I     KPW    
Sbjct: 76  TLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWL--- 132

Query: 139 DYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELC 194
                G GLL+  G+ W R R     AF   ++KP   MK+ NK   ++ D   R   L 
Sbjct: 133 -----GDGLLLSGGDKWSRHRRMLTPAFHFNILKP--YMKIFNKSVNIMHDKWQR---LA 182

Query: 195 DERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMV 254
            E     D++  ++  + +S+   ++       + N  ++   +I AI  + S F     
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFS-----FESNCQEKPSEYIAAILEL-SAFVEKRN 236

Query: 255 TPVELHKSLNTKVWQD-----------HTLAWDTIFKSVKAC-----IDNRLEKYSQQPS 298
             + LH      +  D           H    D + +  +       ID+ L+  ++  +
Sbjct: 237 QQILLHTDFLYYLTPDGQRFRRACHLVHDFT-DAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 299 ADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352
            DF+ D+   ++      LS +++ A          +TTA+ L W+LY+L+++P+ Q++ 
Sbjct: 296 LDFI-DVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQC 354

Query: 353 LKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YAL 409
            +E+Q +L + +    E  DL  +P+L  C+KES+RL P VP  +R   +  VL +   +
Sbjct: 355 RQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVI 414

Query: 410 PKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK-EKINPFAHLPFGVGKRMCIGRRLA 468
           PKG V ++N   +  +   + D   + P R+ QE  ++ +P A +PF  G R CIG+  A
Sbjct: 415 PKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFA 474

Query: 469 ELQLHLALCWIVRKYDIQATDNEP 492
             ++ + L   +  + I  T  EP
Sbjct: 475 MAEMKVVLALTLLHFRILPTHTEP 498


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  112 bits (281), Expect = 6e-25
 Identities = 116/478 (24%), Positives = 193/478 (40%), Gaps = 80/478 (16%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQ-------------------HDTLVEYHKKYGKIFRM 99
           PGPT WPL+G+   +L    L+++                      L    + YG IF  
Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 100 KLGSFESVHLGS-PCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRV 158
            +G +  V L     + EAL +    +  R  +          KE   +    G  W++ 
Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVP---LISIVTKEKGVVFAHYGPVWRQQ 177

Query: 159 RSAFQKKLMKPG-EVMKLDNKINEVLADFMGRIDELCDERGHVEDLY---SELNKWSFES 214
           R      L   G   + L+ KI E        + +      H ED +   S ++      
Sbjct: 178 RKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQK------HGEDPFCPFSIISNAVSNI 231

Query: 215 ICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLA 274
           IC + + +RF                  K M+    R       L   LN++V   +   
Sbjct: 232 ICSLCFGQRFDYTNSE-----------FKKMLGFMSR------GLEICLNSQVLLVNICP 274

Query: 275 W----------------DTIFKSVKACIDNRLEKYSQQPSADFLCDIY-----------H 307
           W                  I   +K  I +  E   ++   DF+ D+Y            
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFI-DMYLLHMEEERKNNS 333

Query: 308 QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPR 367
            +   ++ L+  + +L +A  +TT NSL+W L  +S NP VQ+K+ +EI+ V+  N+ P 
Sbjct: 334 NSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPS 393

Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSE 426
             D   MPY +A + E  RLT  VP        + TVL  Y +PKGT+++ N   +    
Sbjct: 394 LTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDP 453

Query: 427 DNFEDSSQFRPERWLQEK-EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 483
             +E    F P R+L ++ + I     +PFG+GKR+C+G +LA+++L L    +++ +
Sbjct: 454 AIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  112 bits (280), Expect = 8e-25
 Identities = 113/445 (25%), Positives = 190/445 (42%), Gaps = 35/445 (7%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP   PLLG+LLQ+  +G LK    + + + +KYG +F + LG    V L G   + EA
Sbjct: 32  PGPRPLPLLGNLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L     A+  R +I    A  D    GYG++   G  W+ +R  F    M+   + K  +
Sbjct: 88  LVDKAEAFSGRGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSV 142

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E   +    I+EL   +G + D        +   IC +++ KRF    +      
Sbjct: 143 EERIQE---EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQ 295
             F      + S FG++     EL           H   +  + + + A I + +EK+ +
Sbjct: 200 NLFYQTFSLISSVFGQLF----ELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE 254

Query: 296 --QPSADF-LCDIY----------HQNRLSKKELYAAVTELQLAAVETTANSLMWILYNL 342
              PSA   L D Y            +  S + L      L  A  ETT+ +L +    +
Sbjct: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314

Query: 343 SRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKA 401
            + P V +++ +EI+ V+  ++ P   D   MPY +A + E  R +  +P      + + 
Sbjct: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374

Query: 402 TVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPF-AHLPFGVGKR 460
           T    Y +PK T + L           FE    F P+ +L     +    A +PF +GKR
Sbjct: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434

Query: 461 MCIGRRLAELQLHLALCWIVRKYDI 485
           +C+G  +A  +L L    I++ + +
Sbjct: 435 ICLGEGIARAELFLFFTTILQNFSM 459


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  110 bits (275), Expect = 3e-24
 Identities = 99/418 (23%), Positives = 188/418 (44%), Gaps = 50/418 (11%)

Query: 107 VHLGSPCLLEALYRTESAYPQR-----LEIKPWKAYRDYRKEGYGLLILEGEDWQRVRS- 160
           ++L  P ++ ++  T  A   +       +KPW         G GLL+  G+ W+  R  
Sbjct: 99  INLCHPDIVRSVINTSDAITDKDIVFYKTLKPWL--------GDGLLLSVGDKWRHHRRL 150

Query: 161 ---AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL 217
              AF   ++KP   +K+ +K   ++     +   L  E     D++  ++  + +S+  
Sbjct: 151 LTPAFHFNILKP--YIKIFSKSANIMH---AKWQRLAMEGSTCLDVFEHISLMTLDSLQK 205

Query: 218 VLYEKRFGLLQKNAGDEAVNFIMAIKTMM----STFGRM-----MVTPVELHKSLNTKVW 268
            ++       +K +  E +  IM +  ++    + F R       +TP         ++ 
Sbjct: 206 CIFSFDSNCQEKPS--EYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLV 263

Query: 269 QDHTLAWDTIFKSVKAC-----IDNRLEKYSQQPSADF-----LCDIYHQNRLSKKELYA 318
            D T   D + +  +       +D+ L+  ++  + DF     L +  +   LS +++ A
Sbjct: 264 HDFT---DAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRA 320

Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE--DLRNMPY 376
                     +TTA+ L W+LYNL+R+P+ Q++  +E+Q +L + +    E  DL  +P+
Sbjct: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380

Query: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQVLGSSEDNFEDSSQF 435
           L  CLKES+RL P +P   R   +  VL +   +PKG V  +N   +  +   + D   +
Sbjct: 381 LTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVY 440

Query: 436 RPERWLQEK-EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEP 492
            P R+  E  +K +P A +PF  G R CIG++ A  ++ + L   + ++ I     EP
Sbjct: 441 DPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREP 498


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  109 bits (272), Expect = 7e-24
 Identities = 117/489 (23%), Positives = 215/489 (43%), Gaps = 62/489 (12%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGPT  P +G+ LQ+      ++ +++L++  ++YG +F + LG    V L G   + EA
Sbjct: 35  PGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREA 90

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L      +  R E    +A  D+  +GYG++   GE  +++R  F    ++   V K  +
Sbjct: 91  LVDQAEEFSGRGE----QATFDWVFKGYGVVFSNGERAKQLR-RFSIATLRDFGVGKRGI 145

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E  A F+  ID L    G   D    L++     I  +++  RF    K      
Sbjct: 146 EERIQEE-AGFL--IDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDK------ 196

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNT----------KVWQDHTLAWDTIFKSV--- 282
             F+  ++ M+  F     +  +L++  ++          + +Q      D I K V   
Sbjct: 197 -EFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255

Query: 283 ---------KACIDN---RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVET 330
                    +  ID+   R+++  + P+ +F            K L      L +   ET
Sbjct: 256 QRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYL----------KNLVMTTLNLFIGGTET 305

Query: 331 TANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPS 390
            + +L +    L ++P+V+ K+ +EI  V+ +N+ P+ ED   MPY++A + E  R    
Sbjct: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDV 365

Query: 391 VPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINP 449
           +P +  R + K T   ++ LPKGT +      +      F +   F P+ +L EK +   
Sbjct: 366 IPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK 425

Query: 450 F-AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE---PVEMLHSGTLVPSR 505
             A +PF +GKR C G  LA ++L L    +++ + ++++ +     V   H G     R
Sbjct: 426 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPR 485

Query: 506 ELPIAFCQR 514
              ++F  R
Sbjct: 486 NYTMSFLPR 494


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  108 bits (271), Expect = 9e-24
 Identities = 105/453 (23%), Positives = 190/453 (41%), Gaps = 47/453 (10%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGPT  P++G++LQI     +K    +L    K YG +F +  G    V L G   + EA
Sbjct: 31  PGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 86

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LD 176
           L      +  R          +    G+G++   G+ W+ +R      L   G   + ++
Sbjct: 87  LIDLGEEFSGRGHFP----LAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIE 142

Query: 177 NKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQK---NAGD 233
           +++ E   +    ++EL   +    D    L       IC ++++KRF    +   N  +
Sbjct: 143 DRVQE---EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLME 199

Query: 234 EAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKA--------- 284
           +    I  + T          T ++     + K+ ++       I + VK          
Sbjct: 200 KLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINN 259

Query: 285 ------CIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWI 338
                 C   ++EK  Q   ++F  +           L     +L  A  ETT+ +L + 
Sbjct: 260 PRDFIDCFLIKMEKEKQNQQSEFTIE----------NLVITAADLLGAGTETTSTTLRYA 309

Query: 339 LYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTL 398
           L  L ++P+V  K+ +EI+ V+  N+ P  +D  +MPY  A + E  R    +P +    
Sbjct: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 369

Query: 399 DKATV-LGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEK---EKINPFAHLP 454
               V    Y +PKGT ++ +   +      F +   F P  +L E    +K N F  +P
Sbjct: 370 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF--MP 427

Query: 455 FGVGKRMCIGRRLAELQLHLALCWIVRKYDIQA 487
           F  GKR+C+G  LA ++L L L +I++ +++++
Sbjct: 428 FSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  106 bits (265), Expect = 4e-23
 Identities = 110/478 (23%), Positives = 216/478 (45%), Gaps = 52/478 (10%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  P LG++L   + LW            E ++KYG+++ +  G    + +  P +
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDR--------ECNEKYGEMWGLYEGQQPMLVIMDPDM 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKL--MKPG 170
           ++ +   E  S +  ++ + P    +        L   E E+W+R+R+        +K  
Sbjct: 90  IKTVLVKECYSVFTNQMPLGPMGFLKS------ALSFAEDEEWKRIRTLLSPAFTSVKFK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E++ + ++  ++L   + R +    +  +++D +     ++ + I   L+      L  N
Sbjct: 144 EMVPIISQCGDMLVRSL-RQEAENSKSINLKDFFGA---YTMDVITGTLFGVNLDSLN-N 198

Query: 231 AGDE---------AVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKS 281
             D           ++F+     ++S F    +TPV   ++LN  ++      +  +  S
Sbjct: 199 PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPV--FEALNIGLFPKDVTHF--LKNS 252

Query: 282 VKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAVETTA 332
           ++   ++RL K  Q+   DF   +       + + + A+++L+L         AA +TT+
Sbjct: 253 IERMKESRL-KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTS 311

Query: 333 NSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP 392
            +L +I+Y L+ +P VQQKL +EI +VLP       + L  M YL   + E++RL P V 
Sbjct: 312 TTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

Query: 393 FTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE-KEKINPFA 451
             TR   K   +    +PKG  +M+    L      + +  +F PER+ ++ K+ I+ + 
Sbjct: 372 RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYR 431

Query: 452 HLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPI 509
           ++PFG G R CIG R A   + LA+   ++ +  +      + +      +   E PI
Sbjct: 432 YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPI 489


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  106 bits (265), Expect = 4e-23
 Identities = 118/468 (25%), Positives = 203/468 (43%), Gaps = 63/468 (13%)

Query: 59  PGPT---SWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLL 115
           P PT   ++PL+G  L  L K   ++    ++EY ++Y  +  +KL          P  +
Sbjct: 49  PIPTVARAYPLVGHAL--LMKPDGREFFQQIIEYTEEYRHMPLLKLWV-------GPVPM 99

Query: 116 EALYRTESA---YPQRLEIKPWKAYRDYRKE-GYGLLILEGEDWQRVRSAFQKKLMKPGE 171
            ALY  E+         +I     Y+      G GLL   G  W+      ++K++ P  
Sbjct: 100 VALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRS-----RRKMLTPTF 154

Query: 172 VMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSF-----------ESICLVLY 220
                     +L DF+  ++E  +    V+ L   +N+ +F           + IC    
Sbjct: 155 HFT-------ILEDFLDIMNEQANIL--VKKLEKHINQEAFNCFFYITLCALDIICETAM 205

Query: 221 EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQD-------HTL 273
            K  G  Q N   E V  +  +  M+    +M    ++L   +  + W+        HT 
Sbjct: 206 GKNIGA-QSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTF 264

Query: 274 AWDTIFK---SVKACIDNRLEKYSQQPSA-------DFLCDIYHQ--NRLSKKELYAAVT 321
               I +    + A  D R +     PS        D L  +     NRLS +++   V 
Sbjct: 265 TNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVD 324

Query: 322 ELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA-EDLRNMPYLKAC 380
                  +TTA ++ W LY L  NP+VQ+K+  E+  V  ++  P   EDL+ + YL+  
Sbjct: 325 TFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECV 384

Query: 381 LKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERW 440
           +KE++RL PSVP   R++ +   +  Y + KGT  ++    L      F +  +F+PER+
Sbjct: 385 IKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERF 444

Query: 441 LQEK-EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQA 487
             E  +  +P+A++PF  G R CIG++ A ++    L  I+R + I++
Sbjct: 445 FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  106 bits (264), Expect = 6e-23
 Identities = 119/480 (24%), Positives = 211/480 (43%), Gaps = 44/480 (9%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGPT  P +G+ LQ+      ++ +++L++  ++YG +F + LG    V L G   + EA
Sbjct: 35  PGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEA 90

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L      +  R E    +A  D+  +GYG+    GE  +++R  F    ++   V K  +
Sbjct: 91  LVDQAEEFSGRGE----QATFDWLFKGYGVAFSNGERAKQLR-RFSIATLRGFGVGKRGI 145

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E  A F+  ID L    G   D    L++     I  +++  RF    K      
Sbjct: 146 EERIQEE-AGFL--IDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDK------ 196

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID-------- 287
             F+  ++ M+ +F     +  +L++  ++ V +         FK ++   D        
Sbjct: 197 -EFLSLLRMMLGSFQFTATSTGQLYEMFSS-VMKHLPGPQQQAFKELQGLEDFIAKKVEH 254

Query: 288 --NRLEKYSQQPSAD-FLCDIYHQNRLSKKELY---AAVTELQL--AAVETTANSLMWIL 339
               L+  S +   D FL  +  + +    E Y     +T L L  A  ET + +L +  
Sbjct: 255 NQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314

Query: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTL 398
             L ++P+V+ K+ +EI  V+ +N+ P+ ED   MPY +A + E  R    +P      +
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374

Query: 399 DKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPF-AHLPFGV 457
           +K T   ++ LPKGT +      +      F +   F P+ +L +K +     A +PF +
Sbjct: 375 NKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSI 434

Query: 458 GKRMCIGRRLAELQLHLALCWIVRKYDI---QATDNEPVEMLHSGTLVPSRELPIAFCQR 514
           GKR C G  LA ++L L    I++ +     Q+  +  V   H G     R   ++F  R
Sbjct: 435 GKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR 494


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  105 bits (262), Expect = 1e-22
 Identities = 88/367 (23%), Positives = 172/367 (46%), Gaps = 24/367 (6%)

Query: 144 GYGLLILEGEDWQRVRSAFQKKLMKPG---EVMKLD-NKINEVLADFMGRIDELCDERGH 199
           G GL+ L+G  W++ R     +++KPG    ++K+    ++E +   + + +E   +   
Sbjct: 122 GRGLVTLDGSKWKKHR-----QIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSR 176

Query: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTM----MSTF--GRMM 253
           +E L+  ++  + +SI    +  +  +   +  D  +  +  +  +    M+ F     +
Sbjct: 177 LE-LFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDL 235

Query: 254 VTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA----DFLCDIYHQN 309
           V        + +K  Q+     + + +  K  + ++L++ + Q       D L     +N
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 310 R--LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPR 367
               S+ +L A V     A  +TT++++ WILY L++ P+ QQ+   EI+ +L +     
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQVLGSSE 426
            E L  MPY   C+KE +RL   V   +R LDK     +  +LP G  + +N   L  + 
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 427 DNFEDSSQFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDI 485
             +ED   F P R+ +E  EKI+P+A +PF  G R CIG+  A ++  +A+   + ++ +
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL 475

Query: 486 QATDNEP 492
               + P
Sbjct: 476 APDHSRP 482


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  105 bits (261), Expect = 1e-22
 Identities = 92/384 (23%), Positives = 171/384 (44%), Gaps = 34/384 (8%)

Query: 144 GYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLAD----FMGRIDELCDERGH 199
           G GL  L+G  W + R     +L+ PG    +     EV+A      + + +++C  +  
Sbjct: 122 GKGLAALDGPKWFQHR-----RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDT 176

Query: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMM------ 253
             ++Y  +N  S + I    + K       +  D     I  +  ++  F R+       
Sbjct: 177 SVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKII--FHRLYSLLYHS 234

Query: 254 -----VTPVELHKSLNTKVWQDHTLAWDTIF----KSVKACI-DNRLEKYSQQPSADFLC 303
                ++P        ++V   +T   DTI     KS++A +  +   K   Q   D + 
Sbjct: 235 DIIFKLSPQGYRFQKLSRVLNQYT---DTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVL 291

Query: 304 DIYHQN--RLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLP 361
               ++    S  ++++ V+   LA  +T A S+ WILY L+ NP+ Q++  +E++ +L 
Sbjct: 292 SAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILG 351

Query: 362 ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGTVLMLNTQ 420
           +      + L  M Y   C+KE+ RL P+VP  +R L K     +   LP G  ++L+  
Sbjct: 352 DGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIW 411

Query: 421 VLGSSEDNFEDSSQFRPERWLQE-KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWI 479
            L  +   +++   F P R+ QE  ++ +P+A+LPF  G R CIG+  A ++L + +  I
Sbjct: 412 GLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALI 471

Query: 480 VRKYDIQATDNEPVEMLHSGTLVP 503
           +  + +      P+   +   L P
Sbjct: 472 LLHFRVTPDPTRPLTFPNHFILKP 495


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  104 bits (260), Expect = 2e-22
 Identities = 107/476 (22%), Positives = 200/476 (42%), Gaps = 65/476 (13%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP  WPL+G +L +      K  H  L    ++YG + ++++GS   V L G   + +A
Sbjct: 41  PGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95

Query: 118 LYRTESAYP--------------QRLEIKP-----WKAYRDYRKEGYGLLILEGEDWQRV 158
           L R    +               Q +   P     W A R   + G     +  +     
Sbjct: 96  LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 155

Query: 159 RSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLV 218
               ++ + K  EV+             +  + EL    GH    Y  +       IC +
Sbjct: 156 SCYLEEHVSKEAEVL-------------ISTLQELMAGPGHFNP-YRYVVVSVTNVICAI 201

Query: 219 LYEKRFGL----------LQKNAGD-----EAVNFIMAIKTMMSTFGRMMVTPVELHKSL 263
            + +R+            L  N G+        +FI  ++ + +          E   S 
Sbjct: 202 CFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF 261

Query: 264 NTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTEL 323
             K+ ++H   + T  K     I + L ++ Q+   D   ++    +LS +++   V +L
Sbjct: 262 MQKMVKEH---YKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDL 314

Query: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383
             A  +T   ++ W L  L  NP+VQ+K+ +E+ +V+  ++ PR  D  ++PY++A + E
Sbjct: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374

Query: 384 SMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ 442
           + R +  VPFT   +  + T L  + +PKG  + +N   +   +  + + S+F PER+L 
Sbjct: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434

Query: 443 EK---EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEM 495
                +K+     + FG+GKR CIG  +A  ++ L L  ++++ +        V+M
Sbjct: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,948,466
Number of Sequences: 37866
Number of extensions: 904771
Number of successful extensions: 2928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2658
Number of HSP's gapped (non-prelim): 143
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.