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Search of human proteins with 55743136
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
(741 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1495 0.0
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1417 0.0
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1209 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1174 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1165 0.0
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1110 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 558 e-159
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 535 e-152
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 535 e-152
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 433 e-121
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 375 e-104
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 366 e-101
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 291 1e-78
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 291 1e-78
gi|4502023 AKT2 kinase [Homo sapiens] 285 8e-77
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 283 3e-76
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 283 3e-76
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 283 3e-76
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 283 3e-76
gi|62241015 AKT1 kinase [Homo sapiens] 281 2e-75
gi|62241013 AKT1 kinase [Homo sapiens] 281 2e-75
gi|62241011 AKT1 kinase [Homo sapiens] 281 2e-75
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 278 2e-74
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 278 2e-74
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 265 9e-71
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 265 9e-71
gi|5453974 protein kinase N2 [Homo sapiens] 265 1e-70
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 260 3e-69
gi|28557781 protein kinase C, eta [Homo sapiens] 257 3e-68
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 256 4e-68
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1495 bits (3871), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFE 60
MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFE
Sbjct: 1 MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFE 60
Query: 61 KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI 120
KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI
Sbjct: 61 KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI 120
Query: 121 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 180
LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL
Sbjct: 121 LAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 180
Query: 181 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 240
DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN
Sbjct: 181 DHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN 240
Query: 241 RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRA 300
RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRA
Sbjct: 241 RRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRA 300
Query: 301 LFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEF 360
LFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEF
Sbjct: 301 LFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEF 360
Query: 361 TARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFT 420
TARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFT
Sbjct: 361 TARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFT 420
Query: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITL 480
DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITL
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITL 480
Query: 481 KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD 540
KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD
Sbjct: 481 KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD 540
Query: 541 LKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAAC 600
LKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAAC
Sbjct: 541 LKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAAC 600
Query: 601 DIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKM 660
DIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKM
Sbjct: 601 DIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKM 660
Query: 661 LHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLE 720
LHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLE
Sbjct: 661 LHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLE 720
Query: 721 PVLSSNLAQRRGMKRLTSTRL 741
PVLSSNLAQRRGMKRLTSTRL
Sbjct: 721 PVLSSNLAQRRGMKRLTSTRL 741
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1417 bits (3667), Expect = 0.0
Identities = 701/701 (100%), Positives = 701/701 (100%)
Query: 41 EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV 100
EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV
Sbjct: 33 EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV 92
Query: 101 LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 160
LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK
Sbjct: 93 LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152
Query: 161 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 220
EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH
Sbjct: 153 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 212
Query: 221 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 280
DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL
Sbjct: 213 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 272
Query: 281 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 340
KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK
Sbjct: 273 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 332
Query: 341 PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL 400
PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL
Sbjct: 333 PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL 392
Query: 401 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD 460
HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD
Sbjct: 393 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD 452
Query: 461 PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV 520
PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV
Sbjct: 453 PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV 512
Query: 521 LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC 580
LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC
Sbjct: 513 LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC 572
Query: 581 YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA 640
YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA
Sbjct: 573 YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA 632
Query: 641 LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK 700
LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK
Sbjct: 633 LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK 692
Query: 701 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 741
GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL
Sbjct: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1209 bits (3128), Expect = 0.0
Identities = 602/744 (80%), Positives = 664/744 (89%), Gaps = 7/744 (0%)
Query: 1 MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTED--TAEEEEGVVKEIDISHHVKEG 58
MP+AQL + W+K+ VE ++ E + EP E+ + EE +KEI I+HHVKEG
Sbjct: 1 MPLAQLADPWQKMAVESPS-DSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEG 59
Query: 59 FEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118
EKADPSQFELLKVLGQGS+GKVFLV+K+ GSDA QLYAMKVLKKATLKVRDRVR+KMER
Sbjct: 60 HEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
Query: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
DIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL
Sbjct: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
Query: 179 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
ALDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKE+IDH+K+AYSFCGT+EYMAPEV
Sbjct: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
Query: 239 VNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLL 298
VNRRGHTQSADWWSFGVLMFEMLTG+LPFQGKDRKETM +ILKAKLGMPQFLS EAQSLL
Sbjct: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
Query: 299 RALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDP 358
R LFKRNP NRLGAG DGVEEIKRH FF TIDWN LYR+EI PPFKPA GRPEDTF+FDP
Sbjct: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
Query: 359 EFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIH 418
EFTA+TP DSPG+PPSANAH LFRGFSFVA + + Q + V VH IVQQLH N+I
Sbjct: 360 EFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQTVGVHSIVQQLHRNSIQ 417
Query: 419 FTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNII 478
FTDGYE+KEDIGVGSYSVCKRC+HKAT+ E+AVKIIDKSKRDP+EEIEILLRYGQHPNII
Sbjct: 418 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNII 477
Query: 479 TLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVH 538
TLKDVYDDGK+VY+V ELM+GGELLD+ILRQ++FSEREAS VL TITKT++YLH+QGVVH
Sbjct: 478 TLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 537
Query: 539 RDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA 598
RDLKPSNILY DESG+PESIR+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYDA
Sbjct: 538 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA 597
Query: 599 ACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVS 658
ACDIWSLG+LLYTML G+TPFANGPDDTPEEILARIGSGK++LSGG W+S+SD AKD+VS
Sbjct: 598 ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVS 657
Query: 659 KMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVKGAMAATYFALNRTPQAP 717
KMLHVDPHQRLTA VL+HPW+V+ + L QL+RQD HLVKGAMAATY ALNR Q+P
Sbjct: 658 KMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRN-QSP 716
Query: 718 RLEPVLSSNLAQRRGMKRLTSTRL 741
LEPV S LAQRRG+K++TST L
Sbjct: 717 VLEPVGRSTLAQRRGIKKITSTAL 740
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1174 bits (3038), Expect = 0.0
Identities = 580/744 (77%), Positives = 651/744 (87%), Gaps = 12/744 (1%)
Query: 1 MPIAQLLELWKKIEVEPMEIE---TTEEDLNLDVEPTTEDTAEEEEGVVKEIDISHHVKE 57
MP+AQL E W +E+ P++ E T+ E+ L ++EGV+KEI I+HHVK
Sbjct: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQ--------PSKDEGVLKEISITHHVKA 52
Query: 58 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKME 117
G EKADPS FELLKVLGQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KME
Sbjct: 53 GSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKME 112
Query: 118 RDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 177
RDILA+VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA
Sbjct: 113 RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 172
Query: 178 LALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPE 237
L LDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPE
Sbjct: 173 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 232
Query: 238 VVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSL 297
VVNR+GH+ SADWWS+GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSL
Sbjct: 233 VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSL 292
Query: 298 LRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD 357
LRALFKRNP NRLG+G DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD
Sbjct: 293 LRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352
Query: 358 PEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNI 417
EFT+RTP DSPG+PPSA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+
Sbjct: 353 TEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNL 412
Query: 418 HFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNI 477
F+DGY +KE IGVGSYS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNI
Sbjct: 413 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNI 472
Query: 478 ITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVV 537
ITLKDVYDDGK VYLV ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVV
Sbjct: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
Query: 538 HRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYD 597
HRDLKPSNILY DESG+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD
Sbjct: 533 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 592
Query: 598 AACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 657
CDIWSLGILLYTMLAG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+V
Sbjct: 593 EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 652
Query: 658 SKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 717
SKMLHVDPHQRLTA QVL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P
Sbjct: 653 SKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTP 712
Query: 718 RLEPVLSSNLAQRRGMKRLTSTRL 741
+L+P+ SS LAQRR +++L ST L
Sbjct: 713 QLKPIESSILAQRR-VRKLPSTTL 735
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1165 bits (3013), Expect = 0.0
Identities = 575/736 (78%), Positives = 642/736 (87%), Gaps = 2/736 (0%)
Query: 7 LELWKKIEVEPMEIETTEEDLNLDVE-PTTEDTAEEEEGVVKEIDISHHVKEGFEKADPS 65
L LW I P + +L V P + + +EGV+KEI I+HHVK G EKADPS
Sbjct: 10 LRLWALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPS 69
Query: 66 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN 125
FELLKVLGQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VN
Sbjct: 70 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 129
Query: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS 185
HPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHS
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189
Query: 186 LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHT 245
LGIIYRDLKPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 249
Query: 246 QSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRN 305
SADWWS+GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRN
Sbjct: 250 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 309
Query: 306 PCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTP 365
P NRLG+G DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP
Sbjct: 310 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP 369
Query: 366 TDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEI 425
DSPG+PPSA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+ F+DGY +
Sbjct: 370 KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV 429
Query: 426 KEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 485
KE IGVGSYS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYD
Sbjct: 430 KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 489
Query: 486 DGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSN 545
DGK VYLV ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVVHRDLKPSN
Sbjct: 490 DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN 549
Query: 546 ILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSL 605
ILY DESG+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSL
Sbjct: 550 ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609
Query: 606 GILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDP 665
GILLYTMLAG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDP
Sbjct: 610 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
Query: 666 HQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSS 725
HQRLTA QVL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P+L+P+ SS
Sbjct: 670 HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS 729
Query: 726 NLAQRRGMKRLTSTRL 741
LAQRR +++L ST L
Sbjct: 730 ILAQRR-VRKLPSTTL 744
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1110 bits (2871), Expect = 0.0
Identities = 545/713 (76%), Positives = 623/713 (87%), Gaps = 6/713 (0%)
Query: 32 EPTTEDTAEE--EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKG 89
EP E A+ +EGVVKEI I+HHVKEG+EKADP+QFELLKVLGQGS+GKVFLVRK G
Sbjct: 36 EPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTG 95
Query: 90 SDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 149
DAGQLYAMKVLKKA+LKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFL
Sbjct: 96 PDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFL 155
Query: 150 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKIT 209
RGGD+FTRLSKEV+FTEEDVKFYLAELALALDHLH LGI+YRDLKPENILLDE GHIK+T
Sbjct: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215
Query: 210 DFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQG 269
DFGLSKE++D +K+AYSFCGT+EYMAPEVVNRRGH+QSADWWS+GVLMFEMLTG+LPFQG
Sbjct: 216 DFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQG 275
Query: 270 KDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
KDR ETM +ILKAKLGMPQFLS EAQSLLR LFKRNP NRLG+ +GVEEIKRH FF I
Sbjct: 276 KDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANI 333
Query: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389
DW+ LY++E++PPFKPA G+P+DTF FDPEFTA+TP DSPG+P SANAH LF+GFSFVA+
Sbjct: 334 DWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVAT 393
Query: 390 SLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY 449
S+ +E + V PIV Q++GN F + YE+KEDIGVGSYSVCKRC+H T+ E+
Sbjct: 394 SIAEEYKITPITSANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEF 452
Query: 450 AVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQ 509
AVKIIDKSKRDPSEEIEIL+RYGQHPNIITLKDV+DDG++VYLV +LM+GGELLDRIL+Q
Sbjct: 453 AVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQ 512
Query: 510 RYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL 569
+ FSEREASD+L I+KT+DYLH QGVVHRDLKPSNILY DES S +SIR+CDFGFAKQL
Sbjct: 513 KCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL 572
Query: 570 RAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 629
R NGLL+TPCYTANFVAPEVL +QGYDAACDIWSLG+L YTMLAG+TPFANGP+DTPEE
Sbjct: 573 RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
Query: 630 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPN 689
IL RIG+GK++LSGGNWD+ISD AKD++S MLH+DPHQR TA Q+LKH W+ +R+ L +
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPND 692
Query: 690 QLSRQDV-HLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 741
Q R DV H+VKGAM ATY AL P LEPV +S+LAQRR MK+ TST L
Sbjct: 693 QPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL 745
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 558 bits (1438), Expect = e-159
Identities = 312/713 (43%), Positives = 446/713 (62%), Gaps = 36/713 (5%)
Query: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 117
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 118 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 176
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 177 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 235
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 236 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 289
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 290 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 349
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 350 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 409
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
Query: 410 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 456
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
Query: 457 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 516
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
Query: 517 ASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLL 576
AS ++ + + ++H GVVHRDLKP N+L+ DE+ + E I++ DFGFA+ N L
Sbjct: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPL 579
Query: 577 MTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDD----TPEEILA 632
TPC+T ++ APE+L + GYD +CD+WSLG++LYTML+G PF + + EI+
Sbjct: 580 KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 639
Query: 633 RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLS 692
+I G ++ G W ++S AKD++ +L VDP++RL + + W+ + LS N L
Sbjct: 640 KIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 699
Query: 693 RQDVHLVKGA-----MAATYFALNR-TPQAPRLEPVLSSNLAQRRGMKRLTST 739
D+ GA + AT+ A N+ + L+ V + LA+RR MK+ TST
Sbjct: 700 TPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 535 bits (1379), Expect = e-152
Identities = 306/737 (41%), Positives = 444/737 (60%), Gaps = 39/737 (5%)
Query: 40 EEEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 98
+++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAM
Sbjct: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
Query: 99 KVLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLF 155
KVL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
Query: 156 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK 215
T L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSK
Sbjct: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
Query: 216 EAIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRK 273
E + +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
Query: 274 ETMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +
Sbjct: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
Query: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389
DW L ++I PF+P + D +F EFT P SP P +F+G+SFVA
Sbjct: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
Query: 390 SLIQEPSQQDLHKVPVHP----------IVQQLHGNNIHFTDGYEI---KEDIGVGSYSV 436
S++ + + + P + + + F YE+ + +G GS+SV
Sbjct: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSV 424
Query: 437 CKRCVHKATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVME 495
C+RC + + E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+E
Sbjct: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
Query: 496 LMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-G 553
L+RGGELL+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G
Sbjct: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
Query: 554 SPESIRVCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTM 612
+P +++ DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY M
Sbjct: 545 AP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMM 602
Query: 613 LAGFTPF----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR 668
L+G PF G EI+ +I G+++L G W +S+ AK++V +L VDP +R
Sbjct: 603 LSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKR 662
Query: 669 LTAMQVLKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPV 722
L + W+ + S L DV V+ + AT+ A NR + L+ V
Sbjct: 663 LKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSV 722
Query: 723 LSSNLAQRRGMKRLTST 739
++ LA+RR K ++T
Sbjct: 723 ENAPLAKRRKQKLRSAT 739
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 535 bits (1377), Expect = e-152
Identities = 306/731 (41%), Positives = 441/731 (60%), Gaps = 33/731 (4%)
Query: 40 EEEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 98
+++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAM
Sbjct: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
Query: 99 KVLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLF 155
KVL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
Query: 156 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK 215
T L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSK
Sbjct: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
Query: 216 EAIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRK 273
E + +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
Query: 274 ETMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +
Sbjct: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
Query: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389
DW L ++I PF+P + D +F EFT P SP P +F+G+SFVA
Sbjct: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
Query: 390 SLIQEPSQQDLHKVPVHPIVQQLHGN----NIHFTDGYEI---KEDIGVGSYSVCKRCVH 442
S++ + + + P G YE+ + +G GS+SVC+RC
Sbjct: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQ 424
Query: 443 KATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGE 501
+ + E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+EL+RGGE
Sbjct: 425 RQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGE 484
Query: 502 LLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GSPESIR 559
LL+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G+P ++
Sbjct: 485 LLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VK 542
Query: 560 VCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 618
+ DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY ML+G P
Sbjct: 543 IIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVP 602
Query: 619 F----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQV 674
F G EI+ +I G+++L G W +S+ AK++V +L VDP +RL +
Sbjct: 603 FQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGL 662
Query: 675 LKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVLSSNLA 728
W+ + S L DV V+ + AT+ A NR + L+ V ++ LA
Sbjct: 663 RGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA 722
Query: 729 QRRGMKRLTST 739
+RR K ++T
Sbjct: 723 KRRKQKLRSAT 733
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 433 bits (1113), Expect = e-121
Identities = 235/507 (46%), Positives = 326/507 (64%), Gaps = 24/507 (4%)
Query: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 117
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 118 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 176
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 177 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 235
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 236 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 289
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 290 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 349
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 350 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 409
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
Query: 410 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 456
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
Query: 457 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 516
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
Query: 517 ASDVLCTITKTMDYLHSQGVVHRDLKP 543
AS ++ + + ++H GVVHRDLKP
Sbjct: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKP 547
Score = 106 bits (265), Expect = 7e-23
Identities = 83/323 (25%), Positives = 161/323 (49%), Gaps = 30/323 (9%)
Query: 421 DGYEIKEDIGVGSYS---VCKRCVHKATDTEYAVKIIDKS----KRDPSE----EIEILL 469
+ +E+ + +G G+Y + ++ T YA+K++ K+ K +E E ++L
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 470 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 529
Q P ++TL + ++L+++ + GGEL + ++ F+E E + I ++
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Query: 530 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAP 588
+LH G+++RD+K NIL D +G + + DFG +K+ A + C T ++AP
Sbjct: 167 HLHKLGIIYRDIKLENILL-DSNG---HVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 589 EVLK--RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGN 645
++++ G+D A D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
Query: 646 WDSISDAAKDVVSKMLHVDPHQRL-----TAMQVLKHPWV--VNREYLSPNQLSRQDVHL 698
+S AKD++ ++L DP +RL A ++ +H + +N + L+ ++ +
Sbjct: 280 -QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
Query: 699 VKGAMAATYFALNRTPQAPRLEP 721
++ + + FA T P P
Sbjct: 339 IRDELDVSNFAEEFTEMDPTYSP 361
Score = 83.2 bits (204), Expect = 8e-16
Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 13/129 (10%)
Query: 71 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV---NHP 127
K LG+GS+ + RK + Q +A+K++ K R+ + +++I A HP
Sbjct: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
Query: 128 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 187
IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +G
Sbjct: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
Query: 188 IIYRDLKPE 196
+++RDLKPE
Sbjct: 540 VVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 375 bits (964), Expect = e-104
Identities = 184/347 (53%), Positives = 250/347 (72%), Gaps = 3/347 (0%)
Query: 55 VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRV 112
V G EK P FELL+VLG+G YGKVF VRKV G++ G+++AMKVLKKA + +D
Sbjct: 79 VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 138
Query: 113 RSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 172
+K ER+IL EV HPFIV L YAFQT GKLYLIL++L GG+LF +L +E +F E+ FY
Sbjct: 139 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198
Query: 173 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE 232
LAE+++AL HLH GIIYRDLKPENI+L+ +GH+K+TDFGL KE+I ++FCGTIE
Sbjct: 199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 258
Query: 233 YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSG 292
YMAPE++ R GH ++ DWWS G LM++MLTG+ PF G++RK+T+ ILK KL +P +L+
Sbjct: 259 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ 318
Query: 293 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 352
EA+ LL+ L KRN +RLGAG E++ HPFF I+W L ++++PPFKP + ED
Sbjct: 319 EARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEED 378
Query: 353 TFHFDPEFTARTPTDSPGVPP-SANAHHLFRGFSFVASSLIQEPSQQ 398
FD +FT +TP DSP S +A+ +F GF++VA S+++ ++
Sbjct: 379 VSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEK 425
Score = 112 bits (280), Expect = 1e-24
Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 30/284 (10%)
Query: 441 VHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 500
V A DT + K++R+ EE++ HP I+ L + G +YL++E + GG
Sbjct: 131 VRNAKDTAHT-----KAERNILEEVK-------HPFIVDLIYAFQTGGKLYLILEYLSGG 178
Query: 501 ELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRV 560
EL ++ R+ F E A L I+ + +LH +G+++RDLKP NI+ + +++
Sbjct: 179 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG----HVKL 234
Query: 561 CDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFA 620
DFG K+ + T C T ++APE+L R G++ A D WSLG L+Y ML G PF
Sbjct: 235 TDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFT 294
Query: 621 NGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL-----TAMQVL 675
+ ++ + +I K L ++ A+D++ K+L + RL A +V
Sbjct: 295 G---ENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 347
Query: 676 KHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 717
HP+ +N E L ++ L++ + F T Q P
Sbjct: 348 AHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTP 391
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 366 bits (939), Expect = e-101
Identities = 181/356 (50%), Positives = 248/356 (69%), Gaps = 4/356 (1%)
Query: 41 EEEGVVKEIDISH-HVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 99
E G +E++++ V G E+ P FELL+VLG+G YGKVF VRKV+G++ G++YAMK
Sbjct: 40 EPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMK 99
Query: 100 VLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTR 157
VL+KA + +D ++ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT
Sbjct: 100 VLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTH 159
Query: 158 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217
L +E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIK+TDFGL KE+
Sbjct: 160 LEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKES 219
Query: 218 IDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA 277
I ++FCGTIEYMAPE++ R GH ++ DWWS G LM++MLTGS PF ++RK+TM
Sbjct: 220 IHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMD 279
Query: 278 LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRK 337
I++ KL +P +L+ +A+ L++ KRNP R+G G +++RHPFF ++W+ L
Sbjct: 280 KIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339
Query: 338 EIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLI 392
+ PPF+P + ED FD FT +TP DSP S +A+ F GF++VA S++
Sbjct: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
Score = 128 bits (322), Expect = 2e-29
Identities = 90/273 (32%), Positives = 139/273 (50%), Gaps = 28/273 (10%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTE----YAVKIIDKSK--RDPSEEIEI-----LLRY 471
+E+ +G G Y + V K T YA+K++ K+K R+ + +L
Sbjct: 67 FELLRVLGKGGYGKVFQ-VRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILES 125
Query: 472 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 531
+HP I+ L + G +YL++E + GGEL + R+ F E A L IT + +L
Sbjct: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
Query: 532 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 591
HSQG+++RDLKP NI+ S I++ DFG K+ + T C T ++APE+L
Sbjct: 186 HSQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEIL 241
Query: 592 KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISD 651
R G++ A D WSLG L+Y ML G PF + ++ + +I GK AL ++
Sbjct: 242 VRSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTP 294
Query: 652 AAKDVVSKMLHVDPHQRL-----TAMQVLKHPW 679
A+D+V K L +P QR+ A V +HP+
Sbjct: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPF 327
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 291 bits (746), Expect = 1e-78
Identities = 150/348 (43%), Positives = 223/348 (64%), Gaps = 13/348 (3%)
Query: 24 EEDLNLDVEPTTE-DTAEEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVF 82
+E+ ++ PT++ D EEE + +HH ++ + F+ LK+LG+G++GKV
Sbjct: 112 QEEERMNCSPTSQIDNIGEEE---MDASTTHHKRKTM-----NDFDYLKLLGKGTFGKVI 163
Query: 83 LVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGK 141
LVR+ +G+ YAMK+LKK + +D V + E +L HPF+ L Y+FQT+ +
Sbjct: 164 LVRE---KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDR 220
Query: 142 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD 201
L +++++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS I+YRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 202 EEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEML 261
++GHIKITDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 262 TGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIK 321
G LPF +D ++ LIL + P+ LS +A+SLL L ++P RLG G D +EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 322 RHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP 369
RH FF ++W +Y K++ PPFKP V DT +FD EFTA+T T +P
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 112 bits (279), Expect = 2e-24
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 482
+G G++ KA+ YA+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 483 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 542
+ + VME + GGEL + R+R FSE I +DYLHS +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 543 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 602
N++ D+ G I++ DFG K+ + T C T ++APEVL+ Y A D
Sbjct: 274 LENLML-DKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 603 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 662
W LG+++Y M+ G PF N + E++ + K+ ++S AK ++S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 663 VDPHQRL-----TAMQVLKH 677
DP++RL A ++++H
Sbjct: 383 KDPNKRLGGGPDDAKEIMRH 402
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 291 bits (746), Expect = 1e-78
Identities = 150/348 (43%), Positives = 223/348 (64%), Gaps = 13/348 (3%)
Query: 24 EEDLNLDVEPTTE-DTAEEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVF 82
+E+ ++ PT++ D EEE + +HH ++ + F+ LK+LG+G++GKV
Sbjct: 112 QEEERMNCSPTSQIDNIGEEE---MDASTTHHKRKTM-----NDFDYLKLLGKGTFGKVI 163
Query: 83 LVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGK 141
LVR+ +G+ YAMK+LKK + +D V + E +L HPF+ L Y+FQT+ +
Sbjct: 164 LVRE---KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDR 220
Query: 142 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD 201
L +++++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS I+YRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 202 EEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEML 261
++GHIKITDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 262 TGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIK 321
G LPF +D ++ LIL + P+ LS +A+SLL L ++P RLG G D +EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 322 RHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP 369
RH FF ++W +Y K++ PPFKP V DT +FD EFTA+T T +P
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 112 bits (279), Expect = 2e-24
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 482
+G G++ KA+ YA+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 483 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 542
+ + VME + GGEL + R+R FSE I +DYLHS +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 543 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 602
N++ D+ G I++ DFG K+ + T C T ++APEVL+ Y A D
Sbjct: 274 LENLML-DKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 603 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 662
W LG+++Y M+ G PF N + E++ + K+ ++S AK ++S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 663 VDPHQRL-----TAMQVLKH 677
DP++RL A ++++H
Sbjct: 383 KDPNKRLGGGPDDAKEIMRH 402
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 285 bits (730), Expect = 8e-77
Identities = 141/329 (42%), Positives = 212/329 (64%), Gaps = 6/329 (1%)
Query: 42 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 101
+ +E++++ V + K + F+ LK+LG+G++GKV LVR+ G+ YAMK+L
Sbjct: 129 DSSTTEEMEVA--VSKARAKVTMNDFDYLKLLGKGTFGKVILVRE---KATGRYYAMKIL 183
Query: 102 KKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 160
+K + +D V + E +L HPF+ L YAFQT +L ++++ GG+LF LS+
Sbjct: 184 RKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
Query: 161 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 220
E +FTEE +FY AE+ AL++LHS ++YRD+K EN++LD++GHIKITDFGL KE I
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
Query: 221 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 280
+FCGT EY+APEV+ + ++ DWW GV+M+EM+ G LPF +D + LIL
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
Query: 281 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 340
++ P+ LS EA+SLL L K++P RLG G +E+ H FF++I+W + +K++
Sbjct: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
Query: 341 PPFKPAVGRPEDTFHFDPEFTARTPTDSP 369
PPFKP V DT +FD EFTA++ T +P
Sbjct: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITP 452
Score = 113 bits (283), Expect = 6e-25
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 482
+G G++ KAT YA+KI+ K +E+ +L+ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 483 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 542
+ + VME GGEL + R+R F+E A I ++YLHS+ VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 543 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 602
N++ D+ G I++ DFG K+ + + T C T ++APEVL+ Y A D
Sbjct: 278 LENLML-DKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 603 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 662
W LG+++Y M+ G PF N + E++ + ++ ++S AK +++ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
Query: 663 VDPHQRL-----TAMQVLKH 677
DP QRL A +V++H
Sbjct: 387 KDPKQRLGGGPSDAKEVMEH 406
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 93 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 330 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
Query: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
FT +S G P + A F GFS+
Sbjct: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 56 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 115
Query: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 116 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 175
Query: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 176 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 234
Query: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 235 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
Query: 614 AGFTPF 619
G PF
Sbjct: 292 YGLPPF 297
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 107 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 223
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 283
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 284 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 343
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 344 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 402
Query: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
FT +S G P + A F GFS+
Sbjct: 403 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 70 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 129
Query: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 130 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 189
Query: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 190 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 248
Query: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 249 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 305
Query: 614 AGFTPF 619
G PF
Sbjct: 306 YGLPPF 311
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 358 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
Query: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
FT +S G P + A F GFS+
Sbjct: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 84 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 143
Query: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 144 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 203
Query: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 204 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 262
Query: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 263 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
Query: 614 AGFTPF 619
G PF
Sbjct: 320 YGLPPF 325
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 188 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 244
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 425 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
Query: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
FT +S G P + A F GFS+
Sbjct: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 151 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 210
Query: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 211 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 270
Query: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 271 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 329
Query: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 330 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
Query: 614 AGFTPF 619
G PF
Sbjct: 387 YGLPPF 392
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (718), Expect = 2e-75
Identities = 150/375 (40%), Positives = 222/375 (59%), Gaps = 18/375 (4%)
Query: 10 WKKIEVEPMEIETTEE--DLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFEKADPS-- 65
W + +ET EE + ++ + ++EE + S G E+ + S
Sbjct: 80 WTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA 139
Query: 66 ---------QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM 116
+FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V +
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTL 196
Query: 117 -ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 175
E +L HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE
Sbjct: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256
Query: 176 LALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYM 234
+ ALD+LHS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316
Query: 235 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEA 294
APEV+ + ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA
Sbjct: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376
Query: 295 QSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTF 354
+SLL L K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 355 HFDPEFTARTPTDSP 369
+FD EFTA+ T +P
Sbjct: 437 YFDEEFTAQMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 476
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 535
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 656 VVSKMLHVDPHQRL-----TAMQVLKH 677
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (718), Expect = 2e-75
Identities = 150/375 (40%), Positives = 222/375 (59%), Gaps = 18/375 (4%)
Query: 10 WKKIEVEPMEIETTEE--DLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFEKADPS-- 65
W + +ET EE + ++ + ++EE + S G E+ + S
Sbjct: 80 WTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA 139
Query: 66 ---------QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM 116
+FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V +
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTL 196
Query: 117 -ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 175
E +L HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE
Sbjct: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256
Query: 176 LALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYM 234
+ ALD+LHS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316
Query: 235 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEA 294
APEV+ + ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA
Sbjct: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376
Query: 295 QSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTF 354
+SLL L K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 355 HFDPEFTARTPTDSP 369
+FD EFTA+ T +P
Sbjct: 437 YFDEEFTAQMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 476
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 535
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 656 VVSKMLHVDPHQRL-----TAMQVLKH 677
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 281 bits (718), Expect = 2e-75
Identities = 150/375 (40%), Positives = 222/375 (59%), Gaps = 18/375 (4%)
Query: 10 WKKIEVEPMEIETTEE--DLNLDVEPTTEDTAEEEEGVVKEIDISHHVKEGFEKADPS-- 65
W + +ET EE + ++ + ++EE + S G E+ + S
Sbjct: 80 WTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA 139
Query: 66 ---------QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM 116
+FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V +
Sbjct: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTL 196
Query: 117 -ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 175
E +L HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE
Sbjct: 197 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 256
Query: 176 LALALDHLHS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYM 234
+ ALD+LHS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+
Sbjct: 257 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 316
Query: 235 APEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEA 294
APEV+ + ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA
Sbjct: 317 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 376
Query: 295 QSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTF 354
+SLL L K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 355 HFDPEFTARTPTDSP 369
+FD EFTA+ T +P
Sbjct: 437 YFDEEFTAQMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 476
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 535
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 656 VVSKMLHVDPHQRL-----TAMQVLKH 677
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 278 bits (710), Expect = 2e-74
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 30 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 86
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 267 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 325
Query: 360 FTARTPTDSPGVPP-----SANAHHLFRGFSF 386
FT + S G P S+ A F GFS+
Sbjct: 326 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
Score = 119 bits (298), Expect = 1e-26
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 475
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 476 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 535
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
Query: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 155 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 210
Query: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 211 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 263
Query: 656 VVSKMLHVDPHQRL 669
++ +LH D QRL
Sbjct: 264 LLQSLLHKDQRQRL 277
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 278 bits (710), Expect = 2e-74
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 90 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 146
Query: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
Query: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
Query: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 327 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 385
Query: 360 FTARTPTDSPGVPP-----SANAHHLFRGFSF 386
FT + S G P S+ A F GFS+
Sbjct: 386 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
Score = 119 bits (298), Expect = 1e-26
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 475
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 476 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 535
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
Query: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 595
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 215 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 270
Query: 596 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 655
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 271 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 323
Query: 656 VVSKMLHVDPHQRL 669
++ +LH D QRL
Sbjct: 324 LLQSLLHKDQRQRL 337
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 265 bits (678), Expect = 9e-71
Identities = 142/309 (45%), Positives = 195/309 (63%), Gaps = 6/309 (1%)
Query: 58 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKM 116
G A P+ F+ LKV+G+GS+GKV L ++ G+ YA+KVL KK L +++
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 117 ERDILAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 175
ER++L + V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 176 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMA 235
+A AL +LHS+ I+YRDLKPENILLD GH+ +TDFGL KE I +FCGT EY+A
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLA 329
Query: 236 PEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQ 295
PEV+ ++ + + DWW G +++EML G PF +D E IL L + +S A
Sbjct: 330 PEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW 389
Query: 296 SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 355
S+L L +++ NRLGA D + EI+ HPFF ++ W L +K+I PPF P V P+D +
Sbjct: 390 SILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRN 448
Query: 356 FDPEFTART 364
FD FT T
Sbjct: 449 FDTAFTEET 457
Score = 112 bits (279), Expect = 2e-24
Identities = 87/298 (29%), Positives = 137/298 (45%), Gaps = 25/298 (8%)
Query: 394 EPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKI 453
E S Q LH + + + TD ++ + IG GS+ K YAVK+
Sbjct: 134 ERSSQKLHSTSQNINLGPSGNPHAKPTD-FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192
Query: 454 IDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI 506
+ K ++ E +LL+ +HP ++ L + + +Y V++ + GGEL +
Sbjct: 193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 507 LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA 566
R+R F E A I + YLHS +V+RDLKP NIL S + + DFG
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL----DSVGHVVLTDFGLC 308
Query: 567 KQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDD 625
K+ A + T C T ++APEV+++Q YD D W LG +LY ML G PF +
Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE 368
Query: 626 TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTA----MQVLKHPW 679
+ IL + S + +S W ++ ++L D RL A +++ HP+
Sbjct: 369 MYDNILHKPLSLRPGVSLTAW--------SILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 265 bits (678), Expect = 9e-71
Identities = 142/309 (45%), Positives = 195/309 (63%), Gaps = 6/309 (1%)
Query: 58 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKM 116
G A P+ F+ LKV+G+GS+GKV L ++ G+ YA+KVL KK L +++
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 117 ERDILAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 175
ER++L + V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 176 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMA 235
+A AL +LHS+ I+YRDLKPENILLD GH+ +TDFGL KE I +FCGT EY+A
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLA 329
Query: 236 PEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQ 295
PEV+ ++ + + DWW G +++EML G PF +D E IL L + +S A
Sbjct: 330 PEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW 389
Query: 296 SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 355
S+L L +++ NRLGA D + EI+ HPFF ++ W L +K+I PPF P V P+D +
Sbjct: 390 SILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRN 448
Query: 356 FDPEFTART 364
FD FT T
Sbjct: 449 FDTAFTEET 457
Score = 112 bits (279), Expect = 2e-24
Identities = 87/298 (29%), Positives = 137/298 (45%), Gaps = 25/298 (8%)
Query: 394 EPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKI 453
E S Q LH + + + TD ++ + IG GS+ K YAVK+
Sbjct: 134 ERSSQKLHSTSQNINLGPSGNPHAKPTD-FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192
Query: 454 IDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI 506
+ K ++ E +LL+ +HP ++ L + + +Y V++ + GGEL +
Sbjct: 193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 507 LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA 566
R+R F E A I + YLHS +V+RDLKP NIL S + + DFG
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL----DSVGHVVLTDFGLC 308
Query: 567 KQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDD 625
K+ A + T C T ++APEV+++Q YD D W LG +LY ML G PF +
Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE 368
Query: 626 TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTA----MQVLKHPW 679
+ IL + S + +S W ++ ++L D RL A +++ HP+
Sbjct: 369 MYDNILHKPLSLRPGVSLTAW--------SILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 265 bits (677), Expect = 1e-70
Identities = 146/366 (39%), Positives = 209/366 (57%), Gaps = 14/366 (3%)
Query: 30 DVEPTTEDTAEEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKG 89
+ +P T + E G+ + D + F D F VLG+G +GKV L
Sbjct: 623 EYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQD---FRCCAVLGRGHFGKVLLAEY--- 676
Query: 90 SDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVN---HPFIVKLHYAFQTEGKLYLI 145
+ +++A+K LKK + RD V S M E+ I VN HPF+V L FQT+ + +
Sbjct: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
Query: 146 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH 205
+++ GGDL + +V F+E FY A + L L +LH I+YRDLK +N+LLD EG
Sbjct: 737 MEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF 795
Query: 206 IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSL 265
+KI DFGL KE + + R +FCGT E++APEV+ +T++ DWW GVL++EML G
Sbjct: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
Query: 266 PFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 325
PF G D +E I+ ++ P+FLS EA S++R L +RNP RLGA E++K+HPF
Sbjct: 856 PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 915
Query: 326 FVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP---SANAHHLFR 382
F IDW+ L K++KPPF P + ED +FD EFT+ P +P P S +FR
Sbjct: 916 FRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFR 975
Query: 383 GFSFVA 388
F ++A
Sbjct: 976 DFDYIA 981
Score = 107 bits (267), Expect = 4e-23
Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 28/309 (9%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILL---------RYGQHPNIIT 479
+G G + +K T+ +A+K + K +E++ L+ +HP ++
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
Query: 480 LKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHR 539
L + + V VME GG+L+ I FSE A + + YLH +V+R
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
Query: 540 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAA 599
DLK N+L E +++ DFG K+ T C T F+APEVL Y A
Sbjct: 782 DLKLDNLLLDTEG----FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRA 837
Query: 600 CDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSK 659
D W LG+L+Y ML G +PF P D EE+ I + + +S A ++ +
Sbjct: 838 VDWWGLGVLIYEMLVGESPF---PGDDEEEVFDSIVNDEVRYP----RFLSTEAISIMRR 890
Query: 660 MLHVDPHQRLTAMQ-----VLKHPW--VVNREYLSPNQLSRQDVHLVKGAMAATYFALNR 712
+L +P +RL A + V KHP+ +++ L ++ + ++G + F
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950
Query: 713 TPQAPRLEP 721
T +AP L P
Sbjct: 951 TSEAPILTP 959
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 260 bits (665), Expect = 3e-69
Identities = 138/309 (44%), Positives = 194/309 (62%), Gaps = 9/309 (2%)
Query: 65 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAE 123
+ F L VLG+GS+GKV L + KG+D +LYA+K+LKK + D V M E+ +LA
Sbjct: 340 TDFNFLMVLGKGSFGKVMLSER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 124 VNHP-FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 182
P F+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+ L
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 183 LHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 242
L S GIIYRDLK +N++LD EGHIKI DFG+ KE I +FCGT +Y+APE++ +
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 243 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALF 302
+ +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ + L
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 303 KRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 362
++P RLG G +G +IK H FF IDW L RKEI+PP+KP DT +FD EFT
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTR 636
Query: 363 R----TPTD 367
+ TPTD
Sbjct: 637 QPVELTPTD 645
Score = 103 bits (256), Expect = 8e-22
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 481
+G GS+ K TD YAVKI+ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 482 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 541
+ +Y VME + GG+L+ I + F E A I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 542 KPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACD 601
K N++ E I++ DFG K+ T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 602 IWSLGILLYTMLAGFTPFANGPDD 625
W+ G+LLY MLAG PF +D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 257 bits (656), Expect = 3e-68
Identities = 139/331 (41%), Positives = 197/331 (59%), Gaps = 10/331 (3%)
Query: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEV- 124
FE ++VLG+GS+GKV L R + G LYA+KVLKK + D V M E+ IL+
Sbjct: 355 FEFIRVLGKGSFGKVMLARV---KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 411
Query: 125 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 184
NHPF+ +L FQT +L+ +++F+ GGDL + K F E +FY AE+ AL LH
Sbjct: 412 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 471
Query: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 244
GIIYRDLK +N+LLD EGH K+ DFG+ KE I + +FCGT +Y+APE++ +
Sbjct: 472 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY 531
Query: 245 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKR 304
+ DWW+ GVL++EML G PF+ ++ + IL ++ P +L +A +L++ +
Sbjct: 532 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTK 591
Query: 305 NPCNRLGAGIDGVEE-IKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR 363
NP RLG+ G E I RHPFF IDW L ++I+PPF+P + ED +FDP+F
Sbjct: 592 NPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKE 651
Query: 364 TPTDSP---GVPPSANAHHLFRGFSFVASSL 391
P +P G P N FR FS+V+ L
Sbjct: 652 EPVLTPIDEGHLPMINQDE-FRNFSYVSPEL 681
Score = 109 bits (272), Expect = 1e-23
Identities = 87/318 (27%), Positives = 140/318 (44%), Gaps = 28/318 (8%)
Query: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQ 473
D +E +G GS+ K T YAVK++ K +++E IL
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533
HP + L + ++ VME + GG+L+ I + R F E A I + +LH
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472
Query: 534 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 593
+G+++RDLK N+L E ++ DFG K+ T C T +++APE+L+
Sbjct: 473 KGIIYRDLKLDNVLLDHEG----HCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
Query: 594 QGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISDA 652
Y A D W++G+LLY ML G PF A DD E IL + W + +
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL------NDEVVYPTW--LHED 580
Query: 653 AKDVVSKMLHVDPHQRLTAM------QVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAAT 706
A ++ + +P RL ++ +L+HP+ ++ N RQ + + +
Sbjct: 581 ATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNH--RQIEPPFRPRIKSR 638
Query: 707 YFALNRTPQAPRLEPVLS 724
N P + EPVL+
Sbjct: 639 EDVSNFDPDFIKEEPVLT 656
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 256 bits (655), Expect = 4e-68
Identities = 144/336 (42%), Positives = 205/336 (61%), Gaps = 14/336 (4%)
Query: 65 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAE 123
+ F L VLG+GS+GKV L + KG+D +LYA+K+LKK + D V M E+ +LA
Sbjct: 340 TDFNFLMVLGKGSFGKVMLSER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 124 VNHP-FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 182
P F+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+ L
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 183 LHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 242
L S GIIYRDLK +N++LD EGHIKI DFG+ KE I +FCGT +Y+APE++ +
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 243 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALF 302
+ +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ + L
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 303 KRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKP-AVGRPEDTFHFDPEFT 361
++P RLG G +G +IK H FF IDW L RKEI+PP+KP A GR + +FD FT
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAE--NFDRFFT 634
Query: 362 ARTPTDSPGVPPSANAHHL----FRGFSFVASSLIQ 393
P +P P ++ F GFSFV S ++
Sbjct: 635 RHPPVLTP--PDQEVIRNIDQSEFEGFSFVNSEFLK 668
Score = 103 bits (256), Expect = 8e-22
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 429 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 481
+G GS+ K TD YAVKI+ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 482 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 541
+ +Y VME + GG+L+ I + F E A I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 542 KPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACD 601
K N++ E I++ DFG K+ T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 602 IWSLGILLYTMLAGFTPFANGPDD 625
W+ G+LLY MLAG PF +D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,630,258
Number of Sequences: 37866
Number of extensions: 1348134
Number of successful extensions: 8156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 745
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 3334
Number of HSP's gapped (non-prelim): 1924
length of query: 741
length of database: 18,247,518
effective HSP length: 110
effective length of query: 631
effective length of database: 14,082,258
effective search space: 8885904798
effective search space used: 8885904798
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.