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Search of human proteins with 55743134
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
(744 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1508 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1418 0.0
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1172 0.0
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1165 0.0
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1163 0.0
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1082 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 566 e-161
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 543 e-154
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 543 e-154
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 433 e-121
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 378 e-104
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 367 e-101
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 295 8e-80
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 295 8e-80
gi|4502023 AKT2 kinase [Homo sapiens] 290 3e-78
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 283 3e-76
gi|62241015 AKT1 kinase [Homo sapiens] 282 9e-76
gi|62241013 AKT1 kinase [Homo sapiens] 282 9e-76
gi|62241011 AKT1 kinase [Homo sapiens] 282 9e-76
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 281 2e-75
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 281 2e-75
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 281 2e-75
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 281 2e-75
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 281 2e-75
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 274 2e-73
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 274 2e-73
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 264 3e-70
gi|4506067 protein kinase C, alpha [Homo sapiens] 259 8e-69
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 258 1e-68
gi|5453974 protein kinase N2 [Homo sapiens] 258 1e-68
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1508 bits (3903), Expect = 0.0
Identities = 744/744 (100%), Positives = 744/744 (100%)
Query: 1 MEQDPKPPRLRLWALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVK 60
MEQDPKPPRLRLWALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVK
Sbjct: 1 MEQDPKPPRLRLWALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVK 60
Query: 61 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM 120
AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM
Sbjct: 61 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM 120
Query: 121 ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 180
ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL
Sbjct: 121 ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 180
Query: 181 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP
Sbjct: 181 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
Query: 241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQS 300
EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQS
Sbjct: 241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQS 300
Query: 301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF
Sbjct: 301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
Query: 361 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKN 420
DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKN
Sbjct: 361 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKN 420
Query: 421 LVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPN 480
LVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPN
Sbjct: 421 LVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPN 480
Query: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 540
IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV
Sbjct: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 540
Query: 541 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 600
VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY
Sbjct: 541 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 600
Query: 601 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDL 660
DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDL
Sbjct: 601 DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDL 660
Query: 661 VSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPT 720
VSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPT
Sbjct: 661 VSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPT 720
Query: 721 PQLKPIESSILAQRRVRKLPSTTL 744
PQLKPIESSILAQRRVRKLPSTTL
Sbjct: 721 PQLKPIESSILAQRRVRKLPSTTL 744
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1418 bits (3671), Expect = 0.0
Identities = 709/732 (96%), Positives = 712/732 (97%), Gaps = 6/732 (0%)
Query: 13 WALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFE 72
W L+ +P P QTS G +G Q DEGVLKEISITHHVKAGSEKADPSHFE
Sbjct: 10 WPLMELVPLD--PENGQTS----GEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFE 63
Query: 73 LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF 132
LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF
Sbjct: 64 LLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPF 123
Query: 133 VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 192
VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI
Sbjct: 124 VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 183
Query: 193 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA 252
IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA
Sbjct: 184 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA 243
Query: 253 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN 312
DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN
Sbjct: 244 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN 303
Query: 313 RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS 372
RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS
Sbjct: 304 RLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDS 363
Query: 373 PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET 432
PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET
Sbjct: 364 PGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKET 423
Query: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 492
IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
Sbjct: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 483
Query: 493 HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 552
HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY
Sbjct: 484 HVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 543
Query: 553 VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL 612
VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL
Sbjct: 544 VDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGIL 603
Query: 613 LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 672
LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR
Sbjct: 604 LYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 663
Query: 673 LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA 732
LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA
Sbjct: 664 LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILA 723
Query: 733 QRRVRKLPSTTL 744
QRRVRKLPSTTL
Sbjct: 724 QRRVRKLPSTTL 735
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1172 bits (3033), Expect = 0.0
Identities = 580/702 (82%), Positives = 633/702 (90%), Gaps = 5/702 (0%)
Query: 45 SDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 104
++E +KEI+ITHHVK G EKADPS FELLKVLGQGSFGKVFLV+K++ D+ LYAMKV
Sbjct: 42 TEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKV 101
Query: 105 LKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
LKKATLKVRDRVRTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSK
Sbjct: 102 LKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 161
Query: 165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH 224
EVMFTEEDVKFYLAELAL LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE+IDH
Sbjct: 162 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDH 221
Query: 225 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 284
EKKAYSFCGTVEYMAPEVVNR+GH+ SADWWS+GVLMFEMLTG+LPFQGKDRKETMT+IL
Sbjct: 222 EKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL 281
Query: 285 KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIK 344
KAKLGMPQFLS EAQSLLR LFKRNPANRLG+GPDG EEIKRH F+STIDWNKLYRREI
Sbjct: 282 KAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIH 341
Query: 345 PPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRA 404
PPFKPA +P+DTFYFD EFT++TPKDSPGIPPSA AHQLFRGFSFVA + DD
Sbjct: 342 PPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAM 399
Query: 405 PQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRD 464
+HS+VQQLH ++ F+DGY VKE IGVGSYS CKRC+HKATNME+AVK+IDKSKRD
Sbjct: 400 QTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRD 459
Query: 465 PSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 524
P+EEIEILLRYGQHPNIITLKDVYDDGK+VY+VTELM+GGELLDKILRQKFFSEREAS V
Sbjct: 460 PTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 519
Query: 525 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPC 584
L TI KTVEYLH+QGVVHRDLKPSNILYVDESGNPE +RICDFGFAKQLRAENGLLMTPC
Sbjct: 520 LFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC 579
Query: 585 YTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFT 644
YTANFVAPEVLKRQGYD CDIWSLG+LLYTML GYTPFANGP DTPEEIL RIGSGKF+
Sbjct: 580 YTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFS 639
Query: 645 LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLV 703
LSGG WN+VS+TAKDLVSKMLHVDPHQRLTA VL+HPW+ D+LPQ QL+ QD LV
Sbjct: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLV 699
Query: 704 KGAMAATYSALNSSKPTPQLKPIESSILAQRR-VRKLPSTTL 744
KGAMAATYSALN ++ +P L+P+ S LAQRR ++K+ ST L
Sbjct: 700 KGAMAATYSALNRNQ-SPVLEPVGRSTLAQRRGIKKITSTAL 740
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1165 bits (3013), Expect = 0.0
Identities = 575/736 (78%), Positives = 642/736 (87%), Gaps = 2/736 (0%)
Query: 10 LRLWALIPWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPS 69
L LW I P + +L V P + + +EGV+KEI I+HHVK G EKADPS
Sbjct: 7 LELWKKIEVEPMEIETTEEDLNLDVE-PTTEDTAEEEEGVVKEIDISHHVKEGFEKADPS 65
Query: 70 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 129
FELLKVLGQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VN
Sbjct: 66 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN 125
Query: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189
HPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHS
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS 185
Query: 190 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS 249
LGIIYRDLKPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+
Sbjct: 186 LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHT 245
Query: 250 HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN 309
SADWWS+GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRN
Sbjct: 246 QSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRN 305
Query: 310 PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP 369
P NRLG+G DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP
Sbjct: 306 PCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTP 365
Query: 370 KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV 429
DSPG+PPSA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+ F+DGY +
Sbjct: 366 TDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEI 425
Query: 430 KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 489
KE IGVGSYS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYD
Sbjct: 426 KEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD 485
Query: 490 DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN 549
DGK VYLV ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVVHRDLKPSN
Sbjct: 486 DGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSN 545
Query: 550 ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609
ILY DESG+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSL
Sbjct: 546 ILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSL 605
Query: 610 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
GILLYTMLAG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDP
Sbjct: 606 GILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDP 665
Query: 670 HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS 729
HQRLTA QVL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P+L+P+ SS
Sbjct: 666 HQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSS 725
Query: 730 ILAQRR-VRKLPSTTL 744
LAQRR +++L ST L
Sbjct: 726 NLAQRRGMKRLTSTRL 741
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1163 bits (3008), Expect = 0.0
Identities = 574/728 (78%), Positives = 639/728 (87%), Gaps = 12/728 (1%)
Query: 18 WLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVL 77
+L RK R + S S R +EGV+KEI I+HHVK G EKADPS FELLKVL
Sbjct: 17 YLRRKSRSKSSSLS-----------RLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVL 65
Query: 78 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 137
GQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VNHPF+VKLH
Sbjct: 66 GQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLH 125
Query: 138 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 197
YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHSLGIIYRDL
Sbjct: 126 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 185
Query: 198 KPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 257
KPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+ SADWWS+
Sbjct: 186 KPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSF 245
Query: 258 GVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSG 317
GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRNP NRLG+G
Sbjct: 246 GVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAG 305
Query: 318 PDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP 377
DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP DSPG+PP
Sbjct: 306 IDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP 365
Query: 378 SAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGS 437
SA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+ F+DGY +KE IGVGS
Sbjct: 366 SANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGS 425
Query: 438 YSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLV 497
YS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK VYLV
Sbjct: 426 YSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
Query: 498 TELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESG 557
ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVVHRDLKPSNILY DESG
Sbjct: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
Query: 558 NPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTML 617
+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSLGILLYTML
Sbjct: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
Query: 618 AGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQ 677
AG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDPHQRLTA Q
Sbjct: 606 AGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQ 665
Query: 678 VLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRR-V 736
VL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P+L+P+ SS LAQRR +
Sbjct: 666 VLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGM 725
Query: 737 RKLPSTTL 744
++L ST L
Sbjct: 726 KRLTSTRL 733
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1082 bits (2799), Expect = 0.0
Identities = 528/699 (75%), Positives = 605/699 (86%), Gaps = 4/699 (0%)
Query: 46 DEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL 105
DEGV+KEI ITHHVK G EKADP+ FELLKVLGQGSFGKVFLVRK T PD+G LYAMKVL
Sbjct: 48 DEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL 107
Query: 106 KKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 165
KKA+LKVRDRVRTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGD+FTRLSKE
Sbjct: 108 KKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE 167
Query: 166 VMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHE 225
V+FTEEDVKFYLAELAL LDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKE++D E
Sbjct: 168 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 227
Query: 226 KKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK 285
KKAYSFCGTVEYMAPEVVNR+GHS SADWWSYGVLMFEMLTG+LPFQGKDR ETM +ILK
Sbjct: 228 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILK 287
Query: 286 AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKP 345
AKLGMPQFLS EAQSLLR LFKRNPANRLGS +G EEIKRH+F++ IDW+KLY+RE++P
Sbjct: 288 AKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQP 345
Query: 346 PFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAP 405
PFKPA +PDDTF FD EFT++TPKDSPG+P SA AHQLF+GFSFVAT + E+
Sbjct: 346 PFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPIT 405
Query: 406 QAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP 465
A + +V Q++G F + Y +KE IGVGSYS CKRC+H TNME+AVK+IDKSKRDP
Sbjct: 406 SANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDP 464
Query: 466 SEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVL 525
SEEIEIL+RYGQHPNIITLKDV+DDG++VYLVT+LM+GGELLD+IL+QK FSEREAS +L
Sbjct: 465 SEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDIL 524
Query: 526 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY 585
+ I KTV+YLH QGVVHRDLKPSNILY+DES + + +RICDFGFAKQLR ENGLL+TPCY
Sbjct: 525 YVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY 584
Query: 586 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 645
TANFVAPEVL +QGYD CDIWSLG+L YTMLAGYTPFANGP+DTPEEIL RIG+GKF+L
Sbjct: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
Query: 646 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVK 704
SGGNW+ +S+ AKDL+S MLH+DPHQR TA+Q+L+H W+T +D+LP Q D+ +VK
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVK 704
Query: 705 GAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 743
GAM ATYSAL P L+P+ +S LAQRR K ++T
Sbjct: 705 GAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTST 743
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 566 bits (1459), Expect = e-161
Identities = 313/746 (41%), Positives = 452/746 (60%), Gaps = 40/746 (5%)
Query: 36 GPGSGPQRDSDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGKVFLVRK 90
G +G D +G + +++ H ++ + EK +FELLKVLG G++GKVFLVRK
Sbjct: 9 GGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRK 68
Query: 91 VTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQTEGKLY 147
++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQTE KL+
Sbjct: 69 ISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLH 128
Query: 148 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE 207
LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K ENILLD
Sbjct: 129 LILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN 188
Query: 208 GHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYGVLMFEM 264
GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS GVLM+E+
Sbjct: 189 GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYEL 248
Query: 265 LTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 320
LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RLG GP
Sbjct: 249 LTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRD 308
Query: 321 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAG 380
A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP P +
Sbjct: 309 ADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQS- 367
Query: 381 AHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS------------DGYV 428
+ +LF+G+SFVA ++ H V++ N+ S D +
Sbjct: 368 SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDL 427
Query: 429 VKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNIITLKDV 487
+ +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI+ L +V
Sbjct: 428 KDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEV 487
Query: 488 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 547
+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVVHRDLKP
Sbjct: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547
Query: 548 SNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 607
N+L+ DE+ N E ++I DFGFA+ +N L TPC+T ++ APE+L + GYDE CD+W
Sbjct: 548 ENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLW 606
Query: 608 SLGILLYTMLAGYTPFANGPSD----TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
SLG++LYTML+G PF + + EI+ +I G F+ G W VS+ AKDL+
Sbjct: 607 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 666
Query: 664 MLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGA-----MAATYSALNSSK 718
+L VDP++RL + + W+ +L + L D+ GA + AT+ A N K
Sbjct: 667 LLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYK 726
Query: 719 PTP-QLKPIESSILAQRRVRKLPSTT 743
L+ ++ + LA+RR K ST+
Sbjct: 727 REGFCLQNVDKAPLAKRRKMKKTSTS 752
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 543 bits (1400), Expect = e-154
Identities = 315/733 (42%), Positives = 437/733 (59%), Gaps = 37/733 (5%)
Query: 44 DSDEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAM 102
D DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAM
Sbjct: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
Query: 103 KVLKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLF 159
KVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
Query: 160 TRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK 219
T L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSK
Sbjct: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
Query: 220 EAIDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QG 273
E + EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
Query: 274 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 333
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +
Sbjct: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
Query: 334 DWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAT 393
DW L R+I PF+P + D F EFT P SP P G ++F+G+SFVA
Sbjct: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
Query: 394 GLMED-------DG--KPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRC 444
++ D DG P A P + V + D + + +G GS+S C+RC
Sbjct: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELD--LREPALGQGSFSVCRRC 422
Query: 445 VHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRG 503
+ + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV EL+RG
Sbjct: 423 RQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRG 482
Query: 504 GELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNPEC 561
GELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G P
Sbjct: 483 GELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP-- 540
Query: 562 LRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGY 620
++I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY ML+G
Sbjct: 541 VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ 600
Query: 621 TPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAK 676
PF G EI+ +I G+F+L G W VSE AK+LV +L VDP +RL +
Sbjct: 601 VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE 660
Query: 677 QVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIESSI 730
+ W+ L D+ V+ + AT+ A N K LK +E++
Sbjct: 661 GLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP 720
Query: 731 LAQRRVRKLPSTT 743
LA+RR +KL S T
Sbjct: 721 LAKRRKQKLRSAT 733
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 543 bits (1400), Expect = e-154
Identities = 316/737 (42%), Positives = 440/737 (59%), Gaps = 39/737 (5%)
Query: 44 DSDEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAM 102
D DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAM
Sbjct: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
Query: 103 KVLKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLF 159
KVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
Query: 160 TRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK 219
T L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSK
Sbjct: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
Query: 220 EAIDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QG 273
E + EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
Query: 274 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 333
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +
Sbjct: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
Query: 334 DWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAT 393
DW L R+I PF+P + D F EFT P SP P G ++F+G+SFVA
Sbjct: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
Query: 394 GLMED-------DG--KPRAPQAP-LHSVVQQLHGKNLVFSDGYVV---KETIGVGSYSE 440
++ D DG P A P +V + ++ F Y + + +G GS+S
Sbjct: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSV 424
Query: 441 CKRCVHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTE 499
C+RC + + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV E
Sbjct: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
Query: 500 LMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-G 557
L+RGGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G
Sbjct: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
Query: 558 NPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTM 616
P ++I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY M
Sbjct: 545 AP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMM 602
Query: 617 LAGYTPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 672
L+G PF G EI+ +I G+F+L G W VSE AK+LV +L VDP +R
Sbjct: 603 LSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKR 662
Query: 673 LTAKQVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPI 726
L + + W+ L D+ V+ + AT+ A N K LK +
Sbjct: 663 LKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSV 722
Query: 727 ESSILAQRRVRKLPSTT 743
E++ LA+RR +KL S T
Sbjct: 723 ENAPLAKRRKQKLRSAT 739
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 433 bits (1114), Expect = e-121
Identities = 235/540 (43%), Positives = 334/540 (61%), Gaps = 29/540 (5%)
Query: 36 GPGSGPQRDSDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGKVFLVRK 90
G +G D +G + +++ H ++ + EK +FELLKVLG G++GKVFLVRK
Sbjct: 9 GGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRK 68
Query: 91 VTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQTEGKLY 147
++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQTE KL+
Sbjct: 69 ISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLH 128
Query: 148 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE 207
LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K ENILLD
Sbjct: 129 LILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN 188
Query: 208 GHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYGVLMFEM 264
GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS GVLM+E+
Sbjct: 189 GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYEL 248
Query: 265 LTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 320
LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RLG GP
Sbjct: 249 LTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRD 308
Query: 321 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAG 380
A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP P +
Sbjct: 309 ADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQS- 367
Query: 381 AHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS------------DGYV 428
+ +LF+G+SFVA ++ H V++ N+ S D +
Sbjct: 368 SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDL 427
Query: 429 VKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNIITLKDV 487
+ +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI+ L +V
Sbjct: 428 KDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEV 487
Query: 488 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 547
+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVVHRDLKP
Sbjct: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547
Score = 108 bits (271), Expect = 1e-23
Identities = 76/264 (28%), Positives = 140/264 (53%), Gaps = 23/264 (8%)
Query: 425 DGYVVKETIGVGSYSEC---KRCVHKATNMEYAVKVIDKS----KRDPSE----EIEILL 473
+ + + + +G G+Y + ++ T YA+KV+ K+ K +E E ++L
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 474 RYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 533
Q P ++TL + ++L+ + + GGEL + +++ F+E E + I +E
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Query: 534 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 592
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 593 EVLK--RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGN 649
++++ G+D+ D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
Query: 650 WNTVSETAKDLVSKMLHVDPHQRL 673
+S AKDL+ ++L DP +RL
Sbjct: 280 -QEMSALAKDLIQRLLMKDPKKRL 302
Score = 83.2 bits (204), Expect = 8e-16
Identities = 47/154 (30%), Positives = 83/154 (53%), Gaps = 18/154 (11%)
Query: 55 ITHHVKAGSEKADP--SHFELL---KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT 109
+T+ ++ K P H++L K LG+GSF + RK S +A+K++ K
Sbjct: 405 VTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-- 459
Query: 110 LKVRDRVRTKMERDILA---DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV 166
R+ +++I A HP +VKLH F + +L+++ L GG+LF R+ K+
Sbjct: 460 -----RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
Query: 167 MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPE 200
F+E + + + +L + H+H +G+++RDLKPE
Sbjct: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 378 bits (970), Expect = e-104
Identities = 196/393 (49%), Positives = 265/393 (67%), Gaps = 22/393 (5%)
Query: 38 GSGPQRDSDEGVLK-EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDS 96
G GP E K EIS T V G EK P FELL+VLG+G +GKVF VRKVT ++
Sbjct: 58 GVGPYELGMEHCEKFEISETS-VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANT 116
Query: 97 GHLYAMKVLKKATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLR 154
G ++AMKVLKKA + +D TK ER+IL +V HPF+V L YAFQT GKLYLIL++L
Sbjct: 117 GKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLS 176
Query: 155 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 214
GG+LF +L +E +F E+ FYLAE+++ L HLH GIIYRDLKPENI+L+ +GH+KLTD
Sbjct: 177 GGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTD 236
Query: 215 FGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 274
FGL KE+I ++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTG+ PF G+
Sbjct: 237 FGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGE 296
Query: 275 DRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTID 334
+RK+T+ ILK KL +P +L+ EA+ LL+ L KRN A+RLG+GP A E++ H F+ I+
Sbjct: 297 NRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 356
Query: 335 WNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP-SAGAHQLFRGFSFVAT 393
W +L R+++PPFKP + +D FD++FT +TP DSP S A+Q+F GF++VA
Sbjct: 357 WEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAP 416
Query: 394 GLMED-----------------DGKPRAPQAPL 409
++E G PR P +P+
Sbjct: 417 SVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPV 449
Score = 115 bits (288), Expect = 1e-25
Identities = 78/262 (29%), Positives = 133/262 (50%), Gaps = 23/262 (8%)
Query: 434 GVGSYSECKRCVHKATNMEYAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKD 486
G G + ++ T +A+KV+ K+ R+ + +L +HP I+ L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
Query: 487 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 546
+ G +YL+ E + GGEL ++ R+ F E A F L I + +LH +G+++RDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 547 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 606
P NI+ ++ G+ +++ DFG K+ + + T C T ++APE+L R G++ D
Sbjct: 221 PENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDW 276
Query: 607 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 666
WSLG L+Y ML G PF + ++ + +I K L +++ A+DL+ K+L
Sbjct: 277 WSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLK 329
Query: 667 VDPHQRL-----TAKQVLQHPW 683
+ RL A +V HP+
Sbjct: 330 RNAASRLGAGPGDAGEVQAHPF 351
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 367 bits (942), Expect = e-101
Identities = 184/383 (48%), Positives = 252/383 (65%), Gaps = 21/383 (5%)
Query: 48 GVLKEISITH-HVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLK 106
G +E+ +T V G E+ P FELL+VLG+G +GKVF VRKV + G +YAMKVL+
Sbjct: 43 GHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLR 102
Query: 107 KATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
KA + +D T+ ER+IL V HPF+V+L YAFQT GKLYLIL+ L GG+LFT L +
Sbjct: 103 KAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLER 162
Query: 165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH 224
E +F E+ FYLAE+ L L HLHS GIIYRDLKPENI+L +GHIKLTDFGL KE+I
Sbjct: 163 EGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHE 222
Query: 225 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 284
++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTGS PF ++RK+TM I+
Sbjct: 223 GAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKII 282
Query: 285 KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIK 344
+ KL +P +L+ +A+ L++ KRNP+ R+G GP A +++RH F+ ++W+ L +
Sbjct: 283 RGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVD 342
Query: 345 PPFKPAVAQPDDTFYFDTEFTSRTPKDSP-GIPPSAGAHQLFRGFSFVATGLMED----- 398
PPF+P + +D FDT FT +TP DSP S A+Q F GF++VA +++
Sbjct: 343 PPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGF 402
Query: 399 ------------DGKPRAPQAPL 409
+ PRAP +PL
Sbjct: 403 SFQPKLRSPRRLNSSPRAPVSPL 425
Score = 127 bits (319), Expect = 4e-29
Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 23/243 (9%)
Query: 453 YAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 505
YA+KV+ K+K R+ + +L +HP I+ L + G +YL+ E + GGE
Sbjct: 96 YAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGE 155
Query: 506 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 565
L + R+ F E A F L I + +LHSQG+++RDLKP NI+ + +++
Sbjct: 156 LFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH----IKLT 211
Query: 566 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN 625
DFG K+ E + T C T ++APE+L R G++ D WSLG L+Y ML G PF
Sbjct: 212 DFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFT- 270
Query: 626 GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQ 680
++ ++ + +I GK L ++ A+DLV K L +P QR+ A V +
Sbjct: 271 --AENRKKTMDKIIRGKLALP----PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQR 324
Query: 681 HPW 683
HP+
Sbjct: 325 HPF 327
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 295 bits (756), Expect = 8e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 52 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 111
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
Query: 112 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 170
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 171 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 290
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 291 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 350
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 351 VAQPDDTFYFDTEFTSRTPKDSP 373
V DT YFD EFT++T +P
Sbjct: 426 VTSETDTRYFDEEFTAQTITITP 448
Score = 119 bits (297), Expect = 1e-26
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 417 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 470
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 471 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 530
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 531 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 590
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
Query: 591 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 650
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
Query: 651 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
T+S AK L+S +L DP++RL AK++++H
Sbjct: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 295 bits (756), Expect = 8e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 52 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 111
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
Query: 112 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 170
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 171 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 290
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 291 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 350
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 351 VAQPDDTFYFDTEFTSRTPKDSP 373
V DT YFD EFT++T +P
Sbjct: 426 VTSETDTRYFDEEFTAQTITITP 448
Score = 119 bits (297), Expect = 1e-26
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 417 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 470
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 471 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 530
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 531 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 590
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
Query: 591 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 650
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
Query: 651 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
T+S AK L+S +L DP++RL AK++++H
Sbjct: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 290 bits (743), Expect = 3e-78
Identities = 149/351 (42%), Positives = 214/351 (60%), Gaps = 15/351 (4%)
Query: 31 SLPVPGPGSGPQ-----RDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKV 85
SL PG P SD +E+ + V K + F+ LK+LG+G+FGKV
Sbjct: 109 SLKQRAPGEDPMDYKCGSPSDSSTTEEMEVA--VSKARAKVTMNDFDYLKLLGKGTFGKV 166
Query: 86 FLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEG 144
LVR+ +G YAMK+L+K + +D V T E +L + HPF+ L YAFQT
Sbjct: 167 ILVREKA---TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHD 223
Query: 145 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILL 204
+L ++++ GG+LF LS+E +FTEE +FY AE+ L++LHS ++YRD+K EN++L
Sbjct: 224 RLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLML 283
Query: 205 DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEM 264
D++GHIK+TDFGL KE I +FCGT EY+APEV+ + + DWW GV+M+EM
Sbjct: 284 DKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 343
Query: 265 LTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEI 324
+ G LPF +D + LIL ++ P+ LS EA+SLL L K++P RLG GP A+E+
Sbjct: 344 MCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 403
Query: 325 KRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR----TPKD 371
H F+ +I+W + ++++ PPFKP V DT YFD EFT++ TP D
Sbjct: 404 MEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPD 454
Score = 123 bits (309), Expect = 5e-28
Identities = 86/278 (30%), Positives = 140/278 (50%), Gaps = 30/278 (10%)
Query: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EILLRYGQHPNIITLKD 486
+G G++ + KAT YA+K++ K +E+ +L+ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 487 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 546
+ + V E GGEL + R++ F+E A F I +EYLHS+ VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 547 PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 606
N++ +D+ G+ ++I DFG K+ ++ + T C T ++APEVL+ Y D
Sbjct: 278 LENLM-LDKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 607 WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH 666
W LG+++Y M+ G PF N + E++ + +F T+S AK L++ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
Query: 667 VDPHQRL-----TAKQVLQHPW--------VTQKDKLP 691
DP QRL AK+V++H + V QK LP
Sbjct: 387 KDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 283 bits (725), Expect = 3e-76
Identities = 163/404 (40%), Positives = 226/404 (55%), Gaps = 25/404 (6%)
Query: 13 WALIPWLPRKQRPRISQTSLPVPGP----------GSGPQRDSDEGVLKEISITHHVKAG 62
W L PW+ P + + L +P P S P + + +
Sbjct: 27 WCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSA 86
Query: 63 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKME 121
+ A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++ E
Sbjct: 87 NPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIMAE 143
Query: 122 RDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 180
R +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+
Sbjct: 144 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 203
Query: 181 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 240
A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+AP
Sbjct: 204 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 263
Query: 241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQS 300
EV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 264 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 323
Query: 301 LLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D +F
Sbjct: 324 LLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHF 382
Query: 361 DTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 399
D EFT S G P S+GA F GFS+ EDD
Sbjct: 383 DPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 422
Score = 124 bits (312), Expect = 2e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 483
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 99 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 158
Query: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 159 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 218
Query: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 219 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 274
Query: 604 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 275 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 327
Query: 664 MLHVDPHQRLTAK 676
+LH D QRL +K
Sbjct: 328 LLHKDQRQRLGSK 340
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 282 bits (721), Expect = 9e-76
Identities = 149/364 (40%), Positives = 219/364 (60%), Gaps = 15/364 (4%)
Query: 39 SGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGH 98
SG D+ E+S+ + + FE LK+LG+G+FGKV LV++ +G
Sbjct: 122 SGSPSDNSGAEEMEVSLAKP----KHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGR 174
Query: 99 LYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGD 157
YAMK+LKK + +D V T E +L + HPF+ L Y+FQT +L ++++ GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 158 LFTRLSKEVMFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFG 216
LF LS+E +F+E+ +FY AE+ LD+LHS ++YRDLK EN++LD++GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 217 LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDR 276
L KE I +FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354
Query: 277 KETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWN 336
++ LIL ++ P+ L EA+SLL L K++P RLG G + A+EI +H F++ I W
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414
Query: 337 KLYRREIKPPFKPAVAQPDDTFYFDTEFTSR----TPKDSPGIPPSAGAHQL--FRGFSF 390
+Y +++ PPFKP V DT YFD EFT++ TP D + + F FS+
Sbjct: 415 HVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
Query: 391 VATG 394
A+G
Sbjct: 475 SASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 419 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 472
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 473 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 532
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 533 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 652 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 282 bits (721), Expect = 9e-76
Identities = 149/364 (40%), Positives = 219/364 (60%), Gaps = 15/364 (4%)
Query: 39 SGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGH 98
SG D+ E+S+ + + FE LK+LG+G+FGKV LV++ +G
Sbjct: 122 SGSPSDNSGAEEMEVSLAKP----KHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGR 174
Query: 99 LYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGD 157
YAMK+LKK + +D V T E +L + HPF+ L Y+FQT +L ++++ GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 158 LFTRLSKEVMFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFG 216
LF LS+E +F+E+ +FY AE+ LD+LHS ++YRDLK EN++LD++GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 217 LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDR 276
L KE I +FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354
Query: 277 KETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWN 336
++ LIL ++ P+ L EA+SLL L K++P RLG G + A+EI +H F++ I W
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414
Query: 337 KLYRREIKPPFKPAVAQPDDTFYFDTEFTSR----TPKDSPGIPPSAGAHQL--FRGFSF 390
+Y +++ PPFKP V DT YFD EFT++ TP D + + F FS+
Sbjct: 415 HVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
Query: 391 VATG 394
A+G
Sbjct: 475 SASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 419 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 472
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 473 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 532
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 533 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 652 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 282 bits (721), Expect = 9e-76
Identities = 149/364 (40%), Positives = 219/364 (60%), Gaps = 15/364 (4%)
Query: 39 SGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGH 98
SG D+ E+S+ + + FE LK+LG+G+FGKV LV++ +G
Sbjct: 122 SGSPSDNSGAEEMEVSLAKP----KHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGR 174
Query: 99 LYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGD 157
YAMK+LKK + +D V T E +L + HPF+ L Y+FQT +L ++++ GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 158 LFTRLSKEVMFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFG 216
LF LS+E +F+E+ +FY AE+ LD+LHS ++YRDLK EN++LD++GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 217 LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDR 276
L KE I +FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354
Query: 277 KETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWN 336
++ LIL ++ P+ L EA+SLL L K++P RLG G + A+EI +H F++ I W
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 414
Query: 337 KLYRREIKPPFKPAVAQPDDTFYFDTEFTSR----TPKDSPGIPPSAGAHQL--FRGFSF 390
+Y +++ PPFKP V DT YFD EFT++ TP D + + F FS+
Sbjct: 415 HVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
Query: 391 VATG 394
A+G
Sbjct: 475 SASG 478
Score = 120 bits (300), Expect = 6e-27
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 23/275 (8%)
Query: 419 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------EIL 472
K+ V + + + +G G++ + KAT YA+K++ K +E+ +
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 473 LRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 532
L+ +HP + LK + + V E GGEL + R++ FSE A F I +
Sbjct: 202 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
Query: 533 EYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 591
+YLHS+ VV+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++A
Sbjct: 262 DYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
PEVL+ Y D W LG+++Y M+ G PF N + E++ + +F
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------R 370
Query: 652 TVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
T+ AK L+S +L DP QRL AK+++QH
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 281 bits (719), Expect = 2e-75
Identities = 152/335 (45%), Positives = 206/335 (61%), Gaps = 14/335 (4%)
Query: 66 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDI 124
A PS F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++
Sbjct: 93 AKPSDFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 125 LA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
L +V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
Query: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 243
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
Query: 244 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLR 303
++Q + + DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
Query: 304 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTE 363
L +++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD E
Sbjct: 330 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
Query: 364 FTSRTPKDSPGIPPSA--------GAHQLFRGFSF 390
FT +S G P + A + F GFS+
Sbjct: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 424 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 476
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 96 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 154
Query: 477 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 536
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214
Query: 537 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 596
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 215 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 270
Query: 597 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 655
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 271 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 322
Query: 656 TAKDLVSKMLHVDPHQRLTAK 676
+A+ L+ +L D +RL AK
Sbjct: 323 SARHLLEGLLQKDRTKRLGAK 343
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 281 bits (719), Expect = 2e-75
Identities = 152/335 (45%), Positives = 206/335 (61%), Gaps = 14/335 (4%)
Query: 66 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDI 124
A PS F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++
Sbjct: 107 AKPSDFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 125 LA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
L +V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 223
Query: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 243
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 283
Query: 244 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLR 303
++Q + + DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 284 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 343
Query: 304 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTE 363
L +++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD E
Sbjct: 344 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 402
Query: 364 FTSRTPKDSPGIPPSA--------GAHQLFRGFSF 390
FT +S G P + A + F GFS+
Sbjct: 403 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 424 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 476
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 110 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 168
Query: 477 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 536
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 169 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 228
Query: 537 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 596
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 229 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 284
Query: 597 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 655
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 285 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 336
Query: 656 TAKDLVSKMLHVDPHQRLTAK 676
+A+ L+ +L D +RL AK
Sbjct: 337 SARHLLEGLLQKDRTKRLGAK 357
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 281 bits (719), Expect = 2e-75
Identities = 152/335 (45%), Positives = 206/335 (61%), Gaps = 14/335 (4%)
Query: 66 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDI 124
A PS F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 125 LA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
L +V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A
Sbjct: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
Query: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 243
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
Query: 244 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLR 303
++Q + + DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
Query: 304 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTE 363
L +++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD E
Sbjct: 358 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
Query: 364 FTSRTPKDSPGIPPSA--------GAHQLFRGFSF 390
FT +S G P + A + F GFS+
Sbjct: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 424 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 476
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 124 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 182
Query: 477 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 536
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 183 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 242
Query: 537 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 596
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 243 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 298
Query: 597 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 655
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 299 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 350
Query: 656 TAKDLVSKMLHVDPHQRLTAK 676
+A+ L+ +L D +RL AK
Sbjct: 351 SARHLLEGLLQKDRTKRLGAK 371
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 281 bits (719), Expect = 2e-75
Identities = 152/335 (45%), Positives = 206/335 (61%), Gaps = 14/335 (4%)
Query: 66 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDI 124
A PS F LKV+G+GSFGKV L R YA+KVL KKA LK ++ ER++
Sbjct: 188 AKPSDFHFLKVIGKGSFGKVLLARHKAEEV---FYAVKVLQKKAILKKKEEKHIMSERNV 244
Query: 125 LA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
L +V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
Query: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV 243
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE I+H +FCGT EY+APEV+
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
Query: 244 NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLR 303
++Q + + DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
Query: 304 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTE 363
L +++ RLG+ D EIK HVF+S I+W+ L ++I PPF P V+ P+D +FD E
Sbjct: 425 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
Query: 364 FTSRTPKDSPGIPPSA--------GAHQLFRGFSF 390
FT +S G P + A + F GFS+
Sbjct: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Score = 125 bits (314), Expect = 1e-28
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 21/261 (8%)
Query: 424 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYG 476
SD + +K IG GS+ + HKA + YAVKV+ K ++ E +LL+
Sbjct: 191 SDFHFLK-VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 249
Query: 477 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 536
+HP ++ L + +Y V + + GGEL + R++ F E A F I + YLH
Sbjct: 250 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 309
Query: 537 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 596
S +V+RDLKP NIL +D G+ + + DFG K+ N T C T ++APEVL
Sbjct: 310 SLNIVYRDLKPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 365
Query: 597 RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSE 655
+Q YD D W LG +LY ML G PF + ++ + IL + K ++
Sbjct: 366 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK--------PNITN 417
Query: 656 TAKDLVSKMLHVDPHQRLTAK 676
+A+ L+ +L D +RL AK
Sbjct: 418 SARHLLEGLLQKDRTKRLGAK 438
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 281 bits (719), Expect = 2e-75
Identities = 153/346 (44%), Positives = 210/346 (60%), Gaps = 15/346 (4%)
Query: 61 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 119
+ + A P+ F+ LKV+G+G++GKV L + R G YA+KVL KK+ LK +++
Sbjct: 25 SANPNAQPTDFDFLKVIGKGNYGKVLLAK---RKSDGAFYAVKVLQKKSILKKKEQSHIM 81
Query: 120 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 178
ER +L +V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY A
Sbjct: 82 AERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAA 141
Query: 179 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 238
E+A + +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+
Sbjct: 142 EVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYL 201
Query: 239 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 298
APEV+ ++ + + DWW G +++EML G PF +D + IL L +P + A
Sbjct: 202 APEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAA 261
Query: 299 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 358
LL++L ++ RLGS D EIK HVF+S I+W+ LY + + PPF P V P D
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLK 320
Query: 359 YFDTEFTSRTPKDSPGIPP-----SAGAHQLFRGFSFVATGLMEDD 399
+FD EFT S G P S+GA F GFS+ EDD
Sbjct: 321 HFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAP----EDD 362
Score = 124 bits (312), Expect = 2e-28
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 18/253 (7%)
Query: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS----KRDPSE---EIEILLRYGQHPNIIT 483
+ IG G+Y + K+ YAVKV+ K K++ S E +LL+ +HP ++
Sbjct: 39 KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98
Query: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
L+ + + +Y V + + GGEL + R++ F E A F + + YLHS +++R
Sbjct: 99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYR 158
Query: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
DLKP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD
Sbjct: 159 DLKPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRA 214
Query: 604 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
D W LG +LY ML G PF S ++ I + GG + A DL+
Sbjct: 215 VDWWCLGAVLYEMLHGLPPFY---SQDVSQMYENILHQPLQIPGGR----TVAACDLLQS 267
Query: 664 MLHVDPHQRLTAK 676
+LH D QRL +K
Sbjct: 268 LLHKDQRQRLGSK 280
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 274 bits (700), Expect = 2e-73
Identities = 151/340 (44%), Positives = 205/340 (60%), Gaps = 10/340 (2%)
Query: 35 PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90
P S P D DE +++ T +G+ A P+ F+ LKV+G+GSFGKV L +
Sbjct: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180
Query: 91 VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148
R G YA+KVL KK L +++ ER++L +V HPF+V LHY+FQT KLY
Sbjct: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238
Query: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208
+LDF+ GG+LF L +E F E +FY AE+A L +LHS+ I+YRDLKPENILLD G
Sbjct: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
Query: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268
H+ LTDFGL KE I +FCGT EY+APEV+ +Q + ++ DWW G +++EML G
Sbjct: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGL 358
Query: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328
PF +D E IL L + +S A S+L L +++ NRLG+ D EI+ H
Sbjct: 359 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 417
Query: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
F+ ++ W L +++I PPF P VA PDD FDT FT T
Sbjct: 418 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457
Score = 119 bits (298), Expect = 1e-26
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
Query: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 604 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 662
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
Query: 663 KMLHVDPHQRLTAK----QVLQHPW 683
++L D RL AK ++ HP+
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 274 bits (700), Expect = 2e-73
Identities = 151/340 (44%), Positives = 205/340 (60%), Gaps = 10/340 (2%)
Query: 35 PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90
P S P D DE +++ T +G+ A P+ F+ LKV+G+GSFGKV L +
Sbjct: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180
Query: 91 VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148
R G YA+KVL KK L +++ ER++L +V HPF+V LHY+FQT KLY
Sbjct: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238
Query: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208
+LDF+ GG+LF L +E F E +FY AE+A L +LHS+ I+YRDLKPENILLD G
Sbjct: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
Query: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268
H+ LTDFGL KE I +FCGT EY+APEV+ +Q + ++ DWW G +++EML G
Sbjct: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGL 358
Query: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328
PF +D E IL L + +S A S+L L +++ NRLG+ D EI+ H
Sbjct: 359 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 417
Query: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
F+ ++ W L +++I PPF P VA PDD FDT FT T
Sbjct: 418 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457
Score = 119 bits (298), Expect = 1e-26
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
Query: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
Query: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 604 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 662
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
Query: 663 KMLHVDPHQRLTAK----QVLQHPW 683
++L D RL AK ++ HP+
Sbjct: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 264 bits (674), Expect = 3e-70
Identities = 136/307 (44%), Positives = 190/307 (61%), Gaps = 9/307 (2%)
Query: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR-TKMERDILA-DV 128
F L VLG+GSFGKV L R + LYA+K+LKK + D V T +E+ +LA
Sbjct: 342 FNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 129 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 188
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+GL L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248
S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE++ Q +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 308
S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 309 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSR- 367
+P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP DT FD EFT +
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 638
Query: 368 ---TPKD 371
TP D
Sbjct: 639 VELTPTD 645
Score = 103 bits (258), Expect = 4e-22
Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 11/204 (5%)
Query: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 485
+G GS+ + K T+ YAVK++ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 486 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 545
+ +Y V E + GG+L+ I + F E A F I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 546 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 605
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 606 IWSLGILLYTMLAGYTPFANGPSD 629
W+ G+LLY MLAG PF D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 259 bits (661), Expect = 8e-69
Identities = 140/327 (42%), Positives = 196/327 (59%), Gaps = 12/327 (3%)
Query: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR-TKMERDILADVN 129
F L VLG+GSFGKV L R + LYA+K+LKK + D V T +E+ +LA ++
Sbjct: 339 FNFLMVLGKGSFGKVMLA---DRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 130 HP-FVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 188
P F+ +LH FQT +LY +++++ GGDL + + F E FY AE+++GL LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248
GIIYRDLK +N++LD EGHIK+ DFG+ KE + +FCGT +Y+APE++ Q +
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515
Query: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 308
S DWW+YGVL++EML G PF G+D E I++ + P+ LS EA S+ + L +
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTK 575
Query: 309 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
+PA RLG GP+G +++ H F+ IDW KL REI+PPFKP V FD FT
Sbjct: 576 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVC-GKGAENFDKFFTRGQ 634
Query: 369 PKDSPGIPPSAGAHQL----FRGFSFV 391
P +P P + F GFS+V
Sbjct: 635 PVLTP--PDQLVIANIDQSDFEGFSYV 659
Score = 103 bits (258), Expect = 4e-22
Identities = 61/204 (29%), Positives = 102/204 (50%), Gaps = 11/204 (5%)
Query: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 485
+G GS+ + K T YA+K++ K +++E +L + P + L
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 486 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 545
+ +Y V E + GG+L+ I + F E +A F I + +LH +G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 546 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 605
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 465 KLDNVM-LDSEGH---IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVD 520
Query: 606 IWSLGILLYTMLAGYTPFANGPSD 629
W+ G+LLY MLAG PF D
Sbjct: 521 WWAYGVLLYEMLAGQPPFDGEDED 544
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 258 bits (659), Expect = 1e-68
Identities = 141/337 (41%), Positives = 201/337 (59%), Gaps = 12/337 (3%)
Query: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR-TKMERDILA-DV 128
F L VLG+GSFGKV L R + LYA+K+LKK + D V T +E+ +LA
Sbjct: 342 FNFLMVLGKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 129 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 188
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+GL L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248
S GIIYRDLK +N++LD EGHIK+ DFG+ KE I +FCGT +Y+APE++ Q +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 308
S DWW++GVL++EML G PF+G+D E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 309 NPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
+P RLG GP+G +IK H F+ IDW KL R+EI+PP+KP A + FD FT
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK-ACGRNAENFDRFFTRHP 637
Query: 369 PKDSPGIPPSAGAHQL----FRGFSFVATGLMEDDGK 401
P +P P + F GFSFV + ++ + K
Sbjct: 638 PVLTP--PDQEVIRNIDQSEFEGFSFVNSEFLKPEVK 672
Score = 103 bits (258), Expect = 4e-22
Identities = 63/204 (30%), Positives = 103/204 (50%), Gaps = 11/204 (5%)
Query: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 485
+G GS+ + K T+ YAVK++ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 486 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 545
+ +Y V E + GG+L+ I + F E A F I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 546 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCD 605
K N++ +D G+ ++I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 606 IWSLGILLYTMLAGYTPFANGPSD 629
W+ G+LLY MLAG PF D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 258 bits (659), Expect = 1e-68
Identities = 135/329 (41%), Positives = 197/329 (59%), Gaps = 11/329 (3%)
Query: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADVN 129
F VLG+G FGKV L ++ ++A+K LKK + RD V + M E+ I VN
Sbjct: 657 FRCCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 713
Query: 130 ---HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 186
HPF+V L FQT+ + ++++ GGDL + +V F+E FY A + LGL +
Sbjct: 714 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQY 772
Query: 187 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 246
LH I+YRDLK +N+LLD EG +K+ DFGL KE + + + +FCGT E++APEV+
Sbjct: 773 LHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET 832
Query: 247 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 306
++ + DWW GVL++EML G PF G D +E I+ ++ P+FLSTEA S++R L
Sbjct: 833 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
Query: 307 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTS 366
+RNP RLG+ AE++K+H F+ IDW+ L +++KPPF P + +D FD EFTS
Sbjct: 893 RRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTS 952
Query: 367 RTPKDSPGIPP---SAGAHQLFRGFSFVA 392
P +P P S ++FR F ++A
Sbjct: 953 EAPILTPPREPRILSEEEQEMFRDFDYIA 981
Score = 110 bits (276), Expect = 4e-24
Identities = 87/307 (28%), Positives = 143/307 (46%), Gaps = 32/307 (10%)
Query: 397 EDDGKPRAPQAPL-HSVVQQLHGKNLVFSDGYVVKE-----TIGVGSYSECKRCVHKATN 450
+ + KP PQ+ L +S +Q+L + + +++ +G G + + +K TN
Sbjct: 621 QSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTN 680
Query: 451 MEYAVKVIDKSKRDPSEEIEILL---------RYGQHPNIITLKDVYDDGKHVYLVTELM 501
+A+K + K +E++ L+ +HP ++ L + +HV V E
Sbjct: 681 EMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYA 740
Query: 502 RGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPEC 561
GG+L+ I FSE A F + ++YLH +V+RDLK N+L +D G
Sbjct: 741 AGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLL-LDTEG---F 795
Query: 562 LRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYT 621
++I DFG K+ T C T F+APEVL Y D W LG+L+Y ML G +
Sbjct: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
Query: 622 PFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAK 676
PF P D EE+ I + + +S A ++ ++L +P +RL A+
Sbjct: 856 PF---PGDDEEEVFDSIVNDEVRYP----RFLSTEAISIMRRLLRRNPERRLGASEKDAE 908
Query: 677 QVLQHPW 683
V +HP+
Sbjct: 909 DVKKHPF 915
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,621,146
Number of Sequences: 37866
Number of extensions: 1483848
Number of successful extensions: 8283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 746
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 3497
Number of HSP's gapped (non-prelim): 1877
length of query: 744
length of database: 18,247,518
effective HSP length: 110
effective length of query: 634
effective length of database: 14,082,258
effective search space: 8928151572
effective search space used: 8928151572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.