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Search of human proteins with 5453676
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453676 granzyme A precursor [Homo sapiens]
(262 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453676 granzyme A precursor [Homo sapiens] 541 e-154
gi|4504235 granzyme K precursor [Homo sapiens] 211 5e-55
gi|42544239 complement factor D preproprotein [Homo sapiens] 177 8e-45
gi|221625528 granzyme B precursor [Homo sapiens] 167 7e-42
gi|15529990 granzyme H [Homo sapiens] 166 2e-41
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens] 159 3e-39
gi|91823048 kallikrein 14 preproprotein [Homo sapiens] 158 4e-39
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens] 150 1e-36
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens] 150 1e-36
gi|4503149 cathepsin G preproprotein [Homo sapiens] 147 1e-35
gi|4885369 granzyme M precursor [Homo sapiens] 144 1e-34
gi|4502173 prostate specific antigen isoform 1 preproprotein [Ho... 142 2e-34
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 141 5e-34
gi|11496281 kallikrein 13 precursor [Homo sapiens] 141 5e-34
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 137 7e-33
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens] 137 7e-33
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 137 7e-33
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot... 137 9e-33
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 137 1e-32
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 137 1e-32
gi|47551347 protease, serine-like 1 [Homo sapiens] 137 1e-32
gi|22208987 kallikrein 12 isoform 2 [Homo sapiens] 137 1e-32
gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens] 136 2e-32
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s... 135 3e-32
gi|4503549 neutrophil elastase preproprotein [Homo sapiens] 135 4e-32
gi|4504875 kallikrein 1 preproprotein [Homo sapiens] 134 8e-32
gi|4506153 prostasin preproprotein [Homo sapiens] 132 4e-31
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 132 4e-31
gi|9665236 kallikrein 12 isoform 1 [Homo sapiens] 131 5e-31
gi|4505881 plasminogen [Homo sapiens] 130 9e-31
>gi|5453676 granzyme A precursor [Homo sapiens]
Length = 262
Score = 541 bits (1394), Expect = e-154
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 1 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIA 60
MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIA
Sbjct: 1 MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIA 60
Query: 61 KDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQL 120
KDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQL
Sbjct: 61 KDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQL 120
Query: 121 TEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCN 180
TEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCN
Sbjct: 121 TEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCN 180
Query: 181 DRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGP 240
DRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGP
Sbjct: 181 DRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGP 240
Query: 241 GVYILLSKKHLNWIIMTIKGAV 262
GVYILLSKKHLNWIIMTIKGAV
Sbjct: 241 GVYILLSKKHLNWIIMTIKGAV 262
>gi|4504235 granzyme K precursor [Homo sapiens]
Length = 264
Score = 211 bits (537), Expect = 5e-55
Identities = 104/232 (44%), Positives = 149/232 (64%), Gaps = 8/232 (3%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLN----KRSQVILGAH 83
+IIGG EV+PHSRP+M + +C G LI WVLTAAHC + V+LGAH
Sbjct: 26 EIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAH 85
Query: 84 SITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
S+++ E +KQ + +KK P+ + D+ L++L AK+NK+V +LH+ K ++
Sbjct: 86 SLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSK-TSLR 144
Query: 144 PGTMCQVAGWGRTH-NSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
GT C+V GWG T +S SDTLREV +T++ RK+CN +++YN +P I +MVCAG +
Sbjct: 145 SGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAK 204
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254
G +DSC GDSG PL+C+GVF + S G ++CG PG+Y LL+KK+ WI
Sbjct: 205 GQKDSCKGDSGGPLICKGVFHAIVSGG--HECGVATKPGIYTLLTKKYQTWI 254
>gi|42544239 complement factor D preproprotein [Homo sapiens]
Length = 253
Score = 177 bits (449), Expect = 8e-45
Identities = 95/230 (41%), Positives = 140/230 (60%), Gaps = 9/230 (3%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC---NLNKRSQVILGAHS 84
+I+GG E H+RPYM + L+ +C G L+A+ WVL+AAHC + + QV+LGAHS
Sbjct: 25 RILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHS 84
Query: 85 ITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVKP 144
+++ EP+K++ V + P+P P T + DL LLQL+EKA + V L + DV P
Sbjct: 85 LSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAP 144
Query: 145 GTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGG 204
GT+C VAGWG +++ D+L+ V + ++DR CN R H+ + I ++CA S R
Sbjct: 145 GTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH--DGAITERLMCAESNR-- 200
Query: 205 RDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254
RDSC GDSG PL+C GV GV + G CG+ + PG+Y ++ + WI
Sbjct: 201 RDSCKGDSGGPLVCGGVLEGVVTSG-SRVCGNRKKPGIYTRVA-SYAAWI 248
>gi|221625528 granzyme B precursor [Homo sapiens]
Length = 247
Score = 167 bits (424), Expect = 7e-42
Identities = 96/223 (43%), Positives = 130/223 (58%), Gaps = 9/223 (4%)
Query: 14 VVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSL-DRKTI--CAGALIAKDWVLTAAHC 70
++++ LL+P +IIGG+E PHSRPYM L + D+K++ C G LI D+VLTAAHC
Sbjct: 6 LLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHC 65
Query: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130
V LGAH+I +EPT+Q + VK+ P+P Y+P D+ LLQL KAK + V
Sbjct: 66 -WGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAV 124
Query: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITI-IDRKVCNDRNHYNFNP 189
L LP VKPG C VAGWG+T S TL+EV +T+ DRK +D HY +
Sbjct: 125 QPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDST 184
Query: 190 VIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLEN 232
+ +C G + S GDSG PL+C V +G+ S+G N
Sbjct: 185 I----ELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNN 223
>gi|15529990 granzyme H [Homo sapiens]
Length = 246
Score = 166 bits (420), Expect = 2e-41
Identities = 103/250 (41%), Positives = 140/250 (56%), Gaps = 15/250 (6%)
Query: 14 VVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSL----DRKTICAGALIAKDWVLTAAH 69
++++ LL P E+IIGG+E PHSRPYM + RK C G L+ KD+VLTAAH
Sbjct: 6 LLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKR-CGGILVRKDFVLTAAH 64
Query: 70 CNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKY 129
C V LGAH+I +E T+Q + VK+ P+P Y+P D+ LLQL KAK
Sbjct: 65 CQ-GSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTA 123
Query: 130 VTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNP 189
V L LP VKPG +C VAGWG + ++ + TL+EV +T+ C H N++
Sbjct: 124 VRPLRLPSSKAQVKPGQLCSVAGWGYV-SMSTLATTLQEVLLTVQKDCQCERLFHGNYSR 182
Query: 190 VIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKK 249
+C G + + GDSG PL+C+ V +G+ S+G NK G P PGVYI +S
Sbjct: 183 A---TEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYG--NKKGTP--PGVYIKVS-H 234
Query: 250 HLNWIIMTIK 259
L WI T+K
Sbjct: 235 FLPWIKRTMK 244
>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
Length = 247
Score = 159 bits (401), Expect = 3e-39
Identities = 92/224 (41%), Positives = 128/224 (57%), Gaps = 14/224 (6%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKT----ICAGALIAKDWVLTAAHCNLNKRSQVILGAH 83
+IIGG E PHSRPYM L + C G LI +++VLTAAHC + V LGAH
Sbjct: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHC-AGRSITVTLGAH 79
Query: 84 SITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
+IT EE T Q + V K+F +P Y+ +T D+ LL+L EKA + V L P + + V
Sbjct: 80 NITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVP 139
Query: 144 PGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRG 203
PG MC+VAGWGRT SDTL+EV + ++D + C+ ++ N +C G+ R
Sbjct: 140 PGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHN-----LQLCVGNPRK 194
Query: 204 GRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLS 247
+ + GDSG PLLC GV +G+ S+G D + P V+ +S
Sbjct: 195 TKSAFKGDSGGPLLCAGVAQGIVSYGR----SDAKPPAVFTRIS 234
>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
Length = 267
Score = 158 bits (400), Expect = 4e-39
Identities = 96/255 (37%), Positives = 145/255 (56%), Gaps = 12/255 (4%)
Query: 8 LASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLD--RKTICAGALIAKDWVL 65
L ++L V+ + ++ KIIGG+ T S+P+ L R+ +C GAL++ WV+
Sbjct: 20 LLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVI 79
Query: 66 TAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAK 125
TAAHC QV LG H++ R E T+Q++ V ++ +P Y+ T + DL LLQL + A+
Sbjct: 80 TAAHCG-RPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPAR 138
Query: 126 INKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNS-ASWSDTLREVNITIIDRKVCNDRNH 184
I + V + + + PGT C+V+GWG + A + +L+ VNI I +VC
Sbjct: 139 IGRAVRPIEVTQAC--ASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYP 196
Query: 185 YNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYI 244
P MVCAG +GG+DSC GDSG PL+C G +G+ S+G+E +C P PGVY
Sbjct: 197 RTITP----GMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGME-RCALPGYPGVYT 251
Query: 245 LLSKKHLNWIIMTIK 259
L K+ +WI T++
Sbjct: 252 NLC-KYRSWIEETMR 265
>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
Length = 305
Score = 150 bits (378), Expect = 1e-36
Identities = 88/232 (37%), Positives = 132/232 (56%), Gaps = 14/232 (6%)
Query: 27 EKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSIT 86
+K++GG+E PHS+P+ L ++ +C G L+ +WVLTAAHC K + V LG HS+
Sbjct: 76 DKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYT-VRLGDHSLQ 134
Query: 87 REEPTKQIMLVKKEFPYPCYDPATREG---DLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
++ +Q + V + P+PCY+ + E DL LLQL ++A + V + L +
Sbjct: 135 NKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISL--ADHCTQ 192
Query: 144 PGTMCQVAGWGR-THNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
PG C V+GWG T ++ DTL + I +K C D + I MVCAGS +
Sbjct: 193 PGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDA----YPGQITDGMVCAGSSK 248
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254
G D+C GDSG PL+C+G +G+TS+G + CG PGVY + ++L+WI
Sbjct: 249 GA-DTCQGDSGGPLVCDGALQGITSWG-SDPCGRSDKPGVYTNIC-RYLDWI 297
>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
Length = 260
Score = 150 bits (378), Expect = 1e-36
Identities = 88/232 (37%), Positives = 132/232 (56%), Gaps = 14/232 (6%)
Query: 27 EKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSIT 86
+K++GG+E PHS+P+ L ++ +C G L+ +WVLTAAHC K + V LG HS+
Sbjct: 31 DKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYT-VRLGDHSLQ 89
Query: 87 REEPTKQIMLVKKEFPYPCYDPATREG---DLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
++ +Q + V + P+PCY+ + E DL LLQL ++A + V + L +
Sbjct: 90 NKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISL--ADHCTQ 147
Query: 144 PGTMCQVAGWGR-THNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
PG C V+GWG T ++ DTL + I +K C D + I MVCAGS +
Sbjct: 148 PGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDA----YPGQITDGMVCAGSSK 203
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254
G D+C GDSG PL+C+G +G+TS+G + CG PGVY + ++L+WI
Sbjct: 204 GA-DTCQGDSGGPLVCDGALQGITSWG-SDPCGRSDKPGVYTNIC-RYLDWI 252
>gi|4503149 cathepsin G preproprotein [Homo sapiens]
Length = 255
Score = 147 bits (370), Expect = 1e-35
Identities = 94/254 (37%), Positives = 142/254 (55%), Gaps = 20/254 (7%)
Query: 12 LSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDR---KTICAGALIAKDWVLTAA 68
L ++++ LL +IIGG E PHSRPYM L + ++ C G L+ +D+VLTAA
Sbjct: 4 LLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAA 63
Query: 69 HC---NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAK 125
HC N+N V LGAH+I R E T+Q + ++ +P Y+ T + D+ LLQL+ + +
Sbjct: 64 HCWGSNIN----VTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVR 119
Query: 126 INKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHY 185
N+ V + LP+ + ++PGT+C VAGWGR + +DTLREV + + + C R
Sbjct: 120 RNRNVNPVALPRAQEGLRPGTLCTVAGWGRV-SMRRGTDTLREVQLRVQRDRQCL-RIFG 177
Query: 186 NFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYIL 245
+++P +C G R + + GDSG PLLC V G+ S+G G P P V+
Sbjct: 178 SYDP---RRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYG--KSSGVP--PEVFTR 230
Query: 246 LSKKHLNWIIMTIK 259
+S L WI T++
Sbjct: 231 VS-SFLPWIRTTMR 243
>gi|4885369 granzyme M precursor [Homo sapiens]
Length = 257
Score = 144 bits (362), Expect = 1e-34
Identities = 91/252 (36%), Positives = 131/252 (51%), Gaps = 12/252 (4%)
Query: 8 LASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTA 67
++S L + + L + +IIGG EV PHSRPYM L + +C G L+ WVLTA
Sbjct: 5 VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
Query: 68 AHCNLNKRSQV--ILGAHSITREEPTKQIMLVKKEFPYPCYDPATR-EGDLKLLQLTEKA 124
AHC + +Q+ +LG H++ T I K +P Y P E DL LLQL K
Sbjct: 65 AHCLAQRMAQLRLVLGLHTLDSPGLTFHI---KAAIQHPRYKPVPALENDLALLQLDGKV 121
Query: 125 KINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNH 184
K ++ + L LP K V GT C +AGWG TH S LRE+++ ++D ++CN+
Sbjct: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRF 181
Query: 185 YNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLC--EGVFRGVTSFGLENKCGDPRGPGV 242
+N + + +MVC + + C GDSG PL+C V GV SF C D P V
Sbjct: 182 WNGS--LSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFS-SRVCTDIFKPPV 238
Query: 243 YILLSKKHLNWI 254
++ +++WI
Sbjct: 239 ATAVA-PYVSWI 249
>gi|4502173 prostate specific antigen isoform 1 preproprotein [Homo
sapiens]
Length = 261
Score = 142 bits (359), Expect = 2e-34
Identities = 86/246 (34%), Positives = 129/246 (52%), Gaps = 21/246 (8%)
Query: 25 VCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHS 84
+ +I+GG E HS+P+ VL++ + +C G L+ WVLTAAHC NK S ++LG HS
Sbjct: 21 ILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNK-SVILLGRHS 79
Query: 85 ITREEPTKQIMLVKKEFPYPCYDPATREG-----------DLKLLQLTEKAKINKYVTIL 133
+ E T Q+ V FP+P YD + + DL LL+L+E A++ V ++
Sbjct: 80 LFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVM 139
Query: 134 HLPKKGDDVKPGTMCQVAGWGRTHNSASWSDT-LREVNITIIDRKVCNDRNHYNFNPVIG 192
LP + + GT C +GWG + L+ V++ +I VC +
Sbjct: 140 DLPTQEPAL--GTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKF-- 195
Query: 193 MNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLN 252
M+CAG GG+ +C+GDSG PL+C GV +G+TS+G E C P P +Y + +
Sbjct: 196 --MLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSE-PCALPERPSLYTKV-VHYRK 251
Query: 253 WIIMTI 258
WI TI
Sbjct: 252 WIKDTI 257
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 141 bits (356), Expect = 5e-34
Identities = 89/248 (35%), Positives = 131/248 (52%), Gaps = 12/248 (4%)
Query: 12 LSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCN 71
L+ V + L P D +KI+GG +S PY V L+ C G+LI + WV++A HC
Sbjct: 7 LTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYH-FCGGSLINEQWVVSAGHC- 64
Query: 72 LNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVT 131
R QV LG H+I E +Q + K +P YD T D+ L++L+ +A IN V+
Sbjct: 65 YKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVS 124
Query: 132 ILHLPKKGDDVKPGTMCQVAGWGRTHNS-ASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190
+ LP GT C ++GWG T +S A + D L+ ++ ++ + C ++
Sbjct: 125 TISLPTAPPAT--GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEA----SYPGK 178
Query: 191 IGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKH 250
I NM C G L GG+DSC GDSG P++C G +GV S+G + C PGVY + +
Sbjct: 179 ITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG--DGCAQKNKPGVYTKV-YNY 235
Query: 251 LNWIIMTI 258
+ WI TI
Sbjct: 236 VKWIKNTI 243
>gi|11496281 kallikrein 13 precursor [Homo sapiens]
Length = 277
Score = 141 bits (356), Expect = 5e-34
Identities = 84/234 (35%), Positives = 127/234 (54%), Gaps = 13/234 (5%)
Query: 31 GGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITREEP 90
GG PHS+P+ L + + +C G L+ WVLTAAHC L + +V LG H++ R E
Sbjct: 38 GGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHC-LKEGLKVYLGKHALGRVEA 96
Query: 91 TKQIMLVKKEFPYPCYDPA----TREGDLKLLQLTEKAKINKYVTILHLPKKGDDVKPGT 146
+Q+ V P+P Y + + D+ LL+L ++ Y+ L L + + PGT
Sbjct: 97 GEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPL-SHNNRLTPGT 155
Query: 147 MCQVAGWGRTHN-SASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGR 205
C+V+GWG T + ++ TL+ NI + + C + I NM+CAG+ GG+
Sbjct: 156 TCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQV----YPGKITDNMLCAGTKEGGK 211
Query: 206 DSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIK 259
DSC GDSG PL+C G+ S+G + CG P PGVY +S +++ WI TI+
Sbjct: 212 DSCEGDSGGPLVCNRTLYGIVSWG-DFPCGQPDRPGVYTRVS-RYVLWIRETIR 263
>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 137 bits (346), Expect = 7e-33
Identities = 89/237 (37%), Positives = 126/237 (53%), Gaps = 14/237 (5%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITR 87
+II G E PHS+P+ L + +C LIA W+LTAAHC L R V LG H++ +
Sbjct: 21 RIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHC-LKPRYIVHLGQHNLQK 79
Query: 88 EEPTKQIMLVKKEFPYPCYDPAT----REGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
EE +Q + FP+P ++ + D+ L+++ I V L L + V
Sbjct: 80 EEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC--VT 137
Query: 144 PGTMCQVAGWGRTHN-SASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
GT C ++GWG T + TLR NITII+ + C N Y N I MVCA
Sbjct: 138 AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--NAYPGN--ITDTMVCASVQE 193
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIK 259
GG+DSC GDSG PL+C +G+ S+G ++ C R PGVY + K+++WI T+K
Sbjct: 194 GGKDSCQGDSGGPLVCNQSLQGIISWG-QDPCAITRKPGVYTKVC-KYVDWIQETMK 248
>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
Length = 282
Score = 137 bits (346), Expect = 7e-33
Identities = 89/237 (37%), Positives = 126/237 (53%), Gaps = 14/237 (5%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITR 87
+II G E PHS+P+ L + +C LIA W+LTAAHC L R V LG H++ +
Sbjct: 53 RIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHC-LKPRYIVHLGQHNLQK 111
Query: 88 EEPTKQIMLVKKEFPYPCYDPAT----REGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
EE +Q + FP+P ++ + D+ L+++ I V L L + V
Sbjct: 112 EEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC--VT 169
Query: 144 PGTMCQVAGWGRTHN-SASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
GT C ++GWG T + TLR NITII+ + C N Y N I MVCA
Sbjct: 170 AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--NAYPGN--ITDTMVCASVQE 225
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIK 259
GG+DSC GDSG PL+C +G+ S+G ++ C R PGVY + K+++WI T+K
Sbjct: 226 GGKDSCQGDSGGPLVCNQSLQGIISWG-QDPCAITRKPGVYTKVC-KYVDWIQETMK 280
>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 137 bits (346), Expect = 7e-33
Identities = 89/237 (37%), Positives = 126/237 (53%), Gaps = 14/237 (5%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITR 87
+II G E PHS+P+ L + +C LIA W+LTAAHC L R V LG H++ +
Sbjct: 21 RIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHC-LKPRYIVHLGQHNLQK 79
Query: 88 EEPTKQIMLVKKEFPYPCYDPAT----REGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
EE +Q + FP+P ++ + D+ L+++ I V L L + V
Sbjct: 80 EEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC--VT 137
Query: 144 PGTMCQVAGWGRTHN-SASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLR 202
GT C ++GWG T + TLR NITII+ + C N Y N I MVCA
Sbjct: 138 AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE--NAYPGN--ITDTMVCASVQE 193
Query: 203 GGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIK 259
GG+DSC GDSG PL+C +G+ S+G ++ C R PGVY + K+++WI T+K
Sbjct: 194 GGKDSCQGDSGGPLVCNQSLQGIISWG-QDPCAITRKPGVYTKVC-KYVDWIQETMK 248
>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
[Homo sapiens]
Length = 256
Score = 137 bits (345), Expect = 9e-33
Identities = 83/244 (34%), Positives = 131/244 (53%), Gaps = 20/244 (8%)
Query: 27 EKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSIT 86
+K++ G+E PHS+P+ V L + C +LI+ WVL+AAHC ++ +V LG H++
Sbjct: 20 DKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQ-SRFMRVRLGEHNLR 78
Query: 87 REEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVKPGT 146
+ + +Q+ + P+P Y+ + D+ LL+L + A++N V LP + PG
Sbjct: 79 KRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPH--PGE 136
Query: 147 MCQVAGWGR-THNS----------ASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNM 195
C V+GWG +HN S DTL NI+II C+ ++ + M
Sbjct: 137 ACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDK----SYPGRLTNTM 192
Query: 196 VCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWII 255
VCAG+ G +SC GDSG PL+C G+ +G+ S+G + C + PGVY + +L WI
Sbjct: 193 VCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWG-DVPCDNTTKPGVYTKVC-HYLEWIR 250
Query: 256 MTIK 259
T+K
Sbjct: 251 ETMK 254
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 137 bits (344), Expect = 1e-32
Identities = 86/249 (34%), Positives = 130/249 (52%), Gaps = 11/249 (4%)
Query: 12 LSVVVSLLLIP-EDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC 70
L VV+SL+ + K++ G S PY L +C G LI WVLTAAHC
Sbjct: 4 LMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHC 63
Query: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130
QV LG H++ + E +++ V + +P YD A+ + D+ LL+L AK+++ +
Sbjct: 64 K-KPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELI 122
Query: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190
LP + D T C + GWG+T + + DT++ I ++ R+ C + +
Sbjct: 123 Q--PLPLERDCSANTTSCHILGWGKTADG-DFPDTIQCAYIHLVSREECE----HAYPGQ 175
Query: 191 IGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKH 250
I NM+CAG + G+DSC GDSG PL+C RG+ S+G CG PGVY + ++
Sbjct: 176 ITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWG-NIPCGSKEKPGVYTNVC-RY 233
Query: 251 LNWIIMTIK 259
NWI TI+
Sbjct: 234 TNWIQKTIQ 242
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 137 bits (344), Expect = 1e-32
Identities = 86/249 (34%), Positives = 130/249 (52%), Gaps = 11/249 (4%)
Query: 12 LSVVVSLLLIP-EDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC 70
L VV+SL+ + K++ G S PY L +C G LI WVLTAAHC
Sbjct: 4 LMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHC 63
Query: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130
QV LG H++ + E +++ V + +P YD A+ + D+ LL+L AK+++ +
Sbjct: 64 K-KPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELI 122
Query: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190
LP + D T C + GWG+T + + DT++ I ++ R+ C + +
Sbjct: 123 Q--PLPLERDCSANTTSCHILGWGKTADG-DFPDTIQCAYIHLVSREECE----HAYPGQ 175
Query: 191 IGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKH 250
I NM+CAG + G+DSC GDSG PL+C RG+ S+G CG PGVY + ++
Sbjct: 176 ITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWG-NIPCGSKEKPGVYTNVC-RY 233
Query: 251 LNWIIMTIK 259
NWI TI+
Sbjct: 234 TNWIQKTIQ 242
>gi|47551347 protease, serine-like 1 [Homo sapiens]
Length = 283
Score = 137 bits (344), Expect = 1e-32
Identities = 83/226 (36%), Positives = 120/226 (53%), Gaps = 12/226 (5%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLN---KRSQVILGAHS 84
+IIGG+EVTPHSRPYM + + C G L+ WV++AAHC + + V+LGAH
Sbjct: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
Query: 85 ITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLP-KKGDDVK 143
++ EPT+Q+ + +P Y P T D+ LL+L A + V +L LP ++
Sbjct: 93 LSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
Query: 144 PGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRG 203
GT C+VAGWG + L E + ++D VCN ++ + + M+C S
Sbjct: 153 AGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNS----SWKGHLTLTMLCTRSGDS 208
Query: 204 GRDS-CNGDSGSPLLCEGVFRGVTSF-GLENKCGDPRGPGVYILLS 247
R C+ DSG PL+C G+ SF GL CGDP+ P VY +S
Sbjct: 209 HRRGFCSADSGGPLVCRNRAHGLVSFSGL--WCGDPKTPDVYTQVS 252
>gi|22208987 kallikrein 12 isoform 2 [Homo sapiens]
Length = 248
Score = 137 bits (344), Expect = 1e-32
Identities = 92/252 (36%), Positives = 135/252 (53%), Gaps = 12/252 (4%)
Query: 11 SLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC 70
S+ +++ +L + + KI G E +S+P+ V L C G LI WVLTAAHC
Sbjct: 4 SIFLLLCVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHC 63
Query: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPAT--REGDLKLLQLTEKAKINK 128
+ R V LG HS+++ + T+QI +P Y A+ E DL+LL+L ++
Sbjct: 64 S-GSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTS 122
Query: 129 YVTILHLPKKGDDVKPGTMCQVAGWGRT-HNSASWSDTLREVNITIIDRKVCNDRNHYNF 187
V L LP D GT C V+GWG T H + D L+ +N++I+ C H +
Sbjct: 123 SVQPLPLPN--DCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATC----HGVY 176
Query: 188 NPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLS 247
I NMVCAG + G +D+C GDSG PL+C GV +G+ S+G CG PGVY +
Sbjct: 177 PGRITSNMVCAGGVPG-QDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYIC 235
Query: 248 KKHLNWIIMTIK 259
K+++WI M ++
Sbjct: 236 -KYVDWIRMIMR 246
>gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]
Length = 261
Score = 136 bits (343), Expect = 2e-32
Identities = 90/243 (37%), Positives = 126/243 (51%), Gaps = 21/243 (8%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITR 87
+I+GG E HS+P+ V + C G L+ WVLTAAHC L K SQV LG H++
Sbjct: 24 RIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHC-LKKNSQVWLGRHNLFE 82
Query: 88 EEPTKQIMLVKKEFPYPCYDPATREG-----------DLKLLQLTEKAKINKYVTILHLP 136
E T Q + V FP+P Y+ + + DL LL+L+E AKI V +L LP
Sbjct: 83 PEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLP 142
Query: 137 KKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIID-RKVCNDRNHYNFNPVIGMNM 195
+ + GT C +GWG S + LR ++ + + ND ++ + M
Sbjct: 143 TQEPAL--GTTCYASGWG----SIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFM 196
Query: 196 VCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWII 255
+CAG GG+D+C GDSG PL+C GV +G+TS+G E C P P VY + + WI
Sbjct: 197 LCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPE-PCALPEKPAVYTKV-VHYRKWIK 254
Query: 256 MTI 258
TI
Sbjct: 255 DTI 257
>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
sapiens]
Length = 254
Score = 135 bits (341), Expect = 3e-32
Identities = 80/237 (33%), Positives = 125/237 (52%), Gaps = 11/237 (4%)
Query: 26 CEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSI 85
C +II G + +PHS+P+ L ++ + C+G L+ WVL+AAHC N + + LG HS+
Sbjct: 28 CSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYT-IGLGLHSL 86
Query: 86 -TREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVKP 144
+EP Q++ +P Y+ DL L++L E +++ TI +
Sbjct: 87 EADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDE--SVSESDTIRSISIASQCPTA 144
Query: 145 GTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGG 204
G C V+GWG N L+ VN++++ +VC+ ++P+ +M CAG
Sbjct: 145 GNSCLVSGWGLLAN-GRMPTVLQCVNVSVVSEEVCSKL----YDPLYHPSMFCAGGGHDQ 199
Query: 205 RDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIKGA 261
+DSCNGDSG PL+C G +G+ SFG + CG PGVY L K WI T++ +
Sbjct: 200 KDSCNGDSGGPLICNGYLQGLVSFG-KAPCGQVGVPGVYTNLC-KFTEWIEKTVQAS 254
>gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
Length = 267
Score = 135 bits (340), Expect = 4e-32
Identities = 86/246 (34%), Positives = 132/246 (53%), Gaps = 23/246 (9%)
Query: 14 VVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC--N 71
V+ +LLL + +I+GG PH+ P+MV L L C LIA ++V++AAHC N
Sbjct: 15 VLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVAN 74
Query: 72 LNKRS-QVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYV 130
+N R+ +V+LGAH+++R EPT+Q+ V++ F YDP D+ +LQL A IN V
Sbjct: 75 VNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENG-YDPVNLLNDIVILQLNGSATINANV 133
Query: 131 TILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190
+ LP +G + G C GWG + + L+E+N+T++ +C N
Sbjct: 134 QVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRSN------- 185
Query: 191 IGMNMVCAGSLRGGRDS--CNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSK 248
VC +L GR + C GDSGSPL+C G+ G+ SF + C P + ++
Sbjct: 186 -----VC--TLVRGRQAGVCFGDSGSPLVCNGLIHGIASF-VRGGCASGLYPDAFAPVA- 236
Query: 249 KHLNWI 254
+ +NWI
Sbjct: 237 QFVNWI 242
>gi|4504875 kallikrein 1 preproprotein [Homo sapiens]
Length = 262
Score = 134 bits (337), Expect = 8e-32
Identities = 86/244 (35%), Positives = 129/244 (52%), Gaps = 22/244 (9%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITR 87
+I+GG E HS+P+ L C G L+ + WVLTAAHC ++ Q+ LG H++
Sbjct: 24 RIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHC-ISDNYQLWLGRHNLFD 82
Query: 88 EEPTKQIMLVKKEFPYPCYDPATREG-----------DLKLLQLTEKAK-INKYVTILHL 135
+E T Q + V + FP+P ++ + E DL LL+LTE A I V ++ L
Sbjct: 83 DENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVEL 142
Query: 136 PKKGDDVKPGTMCQVAGWGRTH-NSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMN 194
P + +V G+ C +GWG + S+ D L+ V++ I+ C +
Sbjct: 143 PTEEPEV--GSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDF---- 196
Query: 195 MVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254
M+C G L GG+D+C GDSG PL+C+GV +GVTS+G CG P P V + + ++ WI
Sbjct: 197 MLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYV-PCGTPNKPSVAVRV-LSYVKWI 254
Query: 255 IMTI 258
TI
Sbjct: 255 EDTI 258
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 132 bits (331), Expect = 4e-31
Identities = 78/241 (32%), Positives = 125/241 (51%), Gaps = 17/241 (7%)
Query: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC----NLNKRSQVILGAH 83
+I GG+ P+ V ++ + +C G+L+++ WVL+AAHC + + +V LGAH
Sbjct: 44 RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAH 103
Query: 84 SITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLPKKGDDVK 143
+ ++ +K P+P Y +GD+ LLQL+ ++Y+ + LP
Sbjct: 104 QLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFP 163
Query: 144 PGTMCQVAGWGRTHNSAS--WSDTLREVNITIIDRKVCNDRNHYNFNP----VIGMNMVC 197
G C V GWG S S L+++ + +I R+ CN + + P + +MVC
Sbjct: 164 NGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVC 223
Query: 198 AGSLRGGRDSCNGDSGSPLLC--EGVF--RGVTSFGLENKCGDPRGPGVYILLSKKHLNW 253
AG + GG+D+C GDSG PL C EG++ G+ S+G + CG PGVY L S + +W
Sbjct: 224 AGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWG--DACGARNRPGVYTLAS-SYASW 280
Query: 254 I 254
I
Sbjct: 281 I 281
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 132 bits (331), Expect = 4e-31
Identities = 85/248 (34%), Positives = 133/248 (53%), Gaps = 12/248 (4%)
Query: 12 LSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCN 71
L+ V + + +P D +KI+GG +S PY V L+ C G+LI++ WV++AAHC
Sbjct: 7 LAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHC- 64
Query: 72 LNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVT 131
R QV LG H+I E +Q + K +P Y+ T + D+ L++L+ A IN V+
Sbjct: 65 YKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVS 124
Query: 132 ILHLPKKGDDVKPGTMCQVAGWGRTHN-SASWSDTLREVNITIIDRKVCNDRNHYNFNPV 190
+ LP GT C ++GWG T + A + D L+ ++ ++ + C ++
Sbjct: 125 TISLPTAPPAA--GTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKA----SYPGK 178
Query: 191 IGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKH 250
I +M C G L GG+DSC DSG P++C G +GV S+G + C PGVY + +
Sbjct: 179 ITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWG--HGCAWKNRPGVYTKV-YNY 235
Query: 251 LNWIIMTI 258
++WI TI
Sbjct: 236 VDWIKDTI 243
>gi|9665236 kallikrein 12 isoform 1 [Homo sapiens]
Length = 254
Score = 131 bits (330), Expect = 5e-31
Identities = 89/244 (36%), Positives = 127/244 (52%), Gaps = 11/244 (4%)
Query: 11 SLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHC 70
S+ +++ +L + + KI G E +S+P+ V L C G LI WVLTAAHC
Sbjct: 4 SIFLLLCVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHC 63
Query: 71 NLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPAT--REGDLKLLQLTEKAKINK 128
+ R V LG HS+++ + T+QI +P Y A+ E DL+LL+L ++
Sbjct: 64 S-GSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTS 122
Query: 129 YVTILHLPKKGDDVKPGTMCQVAGWGRT-HNSASWSDTLREVNITIIDRKVCNDRNHYNF 187
V L LP D GT C V+GWG T H + D L+ +N++I+ C H +
Sbjct: 123 SVQPLPLPN--DCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATC----HGVY 176
Query: 188 NPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLS 247
I NMVCAG + G +D+C GDSG PL+C GV +G+ S+G CG PGVY +
Sbjct: 177 PGRITSNMVCAGGVPG-QDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYIC 235
Query: 248 KKHL 251
L
Sbjct: 236 NSTL 239
>gi|4505881 plasminogen [Homo sapiens]
Length = 810
Score = 130 bits (328), Expect = 9e-31
Identities = 94/244 (38%), Positives = 126/244 (51%), Gaps = 25/244 (10%)
Query: 22 PEDVCEKIIGGNEVTPHSRPYMVLLSLD-RKTICAGALIAKDWVLTAAHCNLNKRSQ--- 77
P+ +++GG PHS P+ V L C G LI+ +WVLTAAHC L K +
Sbjct: 574 PKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHC-LEKSPRPSS 632
Query: 78 --VILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHL 135
VILGAH EP Q + V + F P TR+ D+ LL+L+ A I V L
Sbjct: 633 YKVILGAHQEVNLEPHVQEIEVSRLFLEP-----TRK-DIALLKLSSPAVITDKVIPACL 686
Query: 136 PKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNF-NPVIGMN 194
P V T C + GWG T + + L+E + +I+ KVCN Y F N +
Sbjct: 687 PSPNYVVADRTECFITGWGETQGTFG-AGLLKEAQLPVIENKVCN---RYEFLNGRVQST 742
Query: 195 MVCAGSLRGGRDSCNGDSGSPLLC----EGVFRGVTSFGLENKCGDPRGPGVYILLSKKH 250
+CAG L GG DSC GDSG PL+C + + +GVTS+GL C P PGVY+ +S +
Sbjct: 743 ELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGL--GCARPNKPGVYVRVS-RF 799
Query: 251 LNWI 254
+ WI
Sbjct: 800 VTWI 803
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,726,663
Number of Sequences: 37866
Number of extensions: 483211
Number of successful extensions: 1395
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 842
Number of HSP's gapped (non-prelim): 190
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.