Search of human proteins with 5453549

Search of human proteins with 5453549

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453549 peroxiredoxin 4 [Homo sapiens]
         (271 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453549 peroxiredoxin 4 [Homo sapiens]                             559   e-160
gi|239757765 PREDICTED: similar to thioredoxin peroxidase [Homo ...   404   e-113
gi|32189392 peroxiredoxin 2 isoform a [Homo sapiens]                  291   3e-79
gi|32455266 peroxiredoxin 1 [Homo sapiens]                            287   8e-78
gi|32455264 peroxiredoxin 1 [Homo sapiens]                            287   8e-78
gi|4505591 peroxiredoxin 1 [Homo sapiens]                             287   8e-78
gi|5802974 peroxiredoxin 3 isoform a precursor [Homo sapiens]         275   3e-74
gi|32483377 peroxiredoxin 3 isoform b [Homo sapiens]                  275   3e-74
gi|33188454 peroxiredoxin 2 isoform c [Homo sapiens]                  128   6e-30
gi|4758638 peroxiredoxin 6 [Homo sapiens]                              64   1e-10
gi|169205475 PREDICTED: similar to peroxiredoxin 6 [Homo sapiens]      33   0.26 
gi|186928821 hepatoma-derived growth factor isoform c [Homo sapi...    30   1.7  
gi|22748713 ankyrin repeat domain 9 [Homo sapiens]                     30   2.9  
gi|11055992 serine carboxypeptidase 1 precursor [Homo sapiens]         29   5.0  
gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens]     28   8.5  
gi|157502173 hypothetical protein LOC348487 [Homo sapiens]             28   8.5  

>gi|5453549 peroxiredoxin 4 [Homo sapiens]
          Length = 271

 Score =  559 bits (1441), Expect = e-160
 Identities = 271/271 (100%), Positives = 271/271 (100%)

Query: 1   MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY 60
           MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY
Sbjct: 1   MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY 60

Query: 61  PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF 120
           PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF
Sbjct: 61  PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF 120

Query: 121 TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL 180
           TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL
Sbjct: 121 TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL 180

Query: 181 THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK 240
           THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK
Sbjct: 181 THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK 240

Query: 241 HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN 271
           HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
Sbjct: 241 HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN 271


>gi|239757765 PREDICTED: similar to thioredoxin peroxidase [Homo
           sapiens]
          Length = 233

 Score =  404 bits (1037), Expect = e-113
 Identities = 208/251 (82%), Positives = 212/251 (84%), Gaps = 24/251 (9%)

Query: 1   MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY 60
           MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY
Sbjct: 1   MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY 60

Query: 61  PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF 120
           PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF
Sbjct: 61  PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF 120

Query: 121 TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL 180
           TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW                     
Sbjct: 121 TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW--------------------- 159

Query: 181 THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK 240
              +S  Y    +     L+GLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK
Sbjct: 160 --SVSYTYIRRKKRMDLLLKGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK 217

Query: 241 HGEVCP-AGWK 250
           HGE  P + WK
Sbjct: 218 HGEDNPRSSWK 228


>gi|32189392 peroxiredoxin 2 isoform a [Homo sapiens]
          Length = 198

 Score =  291 bits (746), Expect = 3e-79
 Identities = 136/193 (70%), Positives = 162/193 (83%)

Query: 79  AKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEF 138
           A+I KPAP ++ TAV+DG FKE+KL+DY+GKY+V FFYPLDFTFVCPTEIIAF +R E+F
Sbjct: 6   ARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDF 65

Query: 139 RSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHT 198
           R +  EV+  SVDSQFTHLAWINTPR++GGLGP+ IPLL+D+T ++S+DYGV   D G  
Sbjct: 66  RKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIA 125

Query: 199 LRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIP 258
            RGLFIID KG+LRQIT+NDLPVGRSVDE LRLVQAFQYTD+HGEVCPAGWKPGS+TI P
Sbjct: 126 YRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKP 185

Query: 259 DPAGKLKYFDKLN 271
           +     +YF K N
Sbjct: 186 NVDDSKEYFSKHN 198


>gi|32455266 peroxiredoxin 1 [Homo sapiens]
          Length = 199

 Score =  287 bits (734), Expect = 8e-78
 Identities = 135/192 (70%), Positives = 160/192 (83%), Gaps = 1/192 (0%)

Query: 79  AKISKPAPYWEGTAVI-DGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEE 137
           AKI  PAP ++ TAV+ DG+FK++ L+DY+GKY+VFFFYPLDFTFVCPTEIIAF DR EE
Sbjct: 6   AKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEE 65

Query: 138 FRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGH 197
           F+ +N +V+  SVDS F HLAW+NTP++QGGLGP+ IPL+SD    I++DYGV   D G 
Sbjct: 66  FKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGI 125

Query: 198 TLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETII 257
           + RGLFIIDDKGILRQIT+NDLPVGRSVDETLRLVQAFQ+TDKHGEVCPAGWKPGS+TI 
Sbjct: 126 SFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIK 185

Query: 258 PDPAGKLKYFDK 269
           PD     +YF K
Sbjct: 186 PDVQKSKEYFSK 197


>gi|32455264 peroxiredoxin 1 [Homo sapiens]
          Length = 199

 Score =  287 bits (734), Expect = 8e-78
 Identities = 135/192 (70%), Positives = 160/192 (83%), Gaps = 1/192 (0%)

Query: 79  AKISKPAPYWEGTAVI-DGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEE 137
           AKI  PAP ++ TAV+ DG+FK++ L+DY+GKY+VFFFYPLDFTFVCPTEIIAF DR EE
Sbjct: 6   AKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEE 65

Query: 138 FRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGH 197
           F+ +N +V+  SVDS F HLAW+NTP++QGGLGP+ IPL+SD    I++DYGV   D G 
Sbjct: 66  FKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGI 125

Query: 198 TLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETII 257
           + RGLFIIDDKGILRQIT+NDLPVGRSVDETLRLVQAFQ+TDKHGEVCPAGWKPGS+TI 
Sbjct: 126 SFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIK 185

Query: 258 PDPAGKLKYFDK 269
           PD     +YF K
Sbjct: 186 PDVQKSKEYFSK 197


>gi|4505591 peroxiredoxin 1 [Homo sapiens]
          Length = 199

 Score =  287 bits (734), Expect = 8e-78
 Identities = 135/192 (70%), Positives = 160/192 (83%), Gaps = 1/192 (0%)

Query: 79  AKISKPAPYWEGTAVI-DGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEE 137
           AKI  PAP ++ TAV+ DG+FK++ L+DY+GKY+VFFFYPLDFTFVCPTEIIAF DR EE
Sbjct: 6   AKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEE 65

Query: 138 FRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGH 197
           F+ +N +V+  SVDS F HLAW+NTP++QGGLGP+ IPL+SD    I++DYGV   D G 
Sbjct: 66  FKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGI 125

Query: 198 TLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETII 257
           + RGLFIIDDKGILRQIT+NDLPVGRSVDETLRLVQAFQ+TDKHGEVCPAGWKPGS+TI 
Sbjct: 126 SFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIK 185

Query: 258 PDPAGKLKYFDK 269
           PD     +YF K
Sbjct: 186 PDVQKSKEYFSK 197


>gi|5802974 peroxiredoxin 3 isoform a precursor [Homo sapiens]
          Length = 256

 Score =  275 bits (703), Expect = 3e-74
 Identities = 127/191 (66%), Positives = 155/191 (81%)

Query: 81  ISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRS 140
           +++ APY++GTAV++GEFK+L L D++GKYLV FFYPLDFTFVCPTEI+AF D+  EF  
Sbjct: 65  VTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHD 124

Query: 141 INTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLR 200
           +N EVVA SVDS F+HLAWINTPR+ GGLG + I LLSDLT QIS+DYGV LE SG  LR
Sbjct: 125 VNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALR 184

Query: 201 GLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDP 260
           GLFIID  G+++ +++NDLPVGRSV+ETLRLV+AFQY + HGEVCPA W P S TI P P
Sbjct: 185 GLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSP 244

Query: 261 AGKLKYFDKLN 271
           A   +YF K+N
Sbjct: 245 AASKEYFQKVN 255


>gi|32483377 peroxiredoxin 3 isoform b [Homo sapiens]
          Length = 238

 Score =  275 bits (703), Expect = 3e-74
 Identities = 128/190 (67%), Positives = 153/190 (80%)

Query: 82  SKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSI 141
           S  APY++GTAV++GEFK+L L D++GKYLV FFYPLDFTFVCPTEI+AF D+  EF  +
Sbjct: 48  SSQAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDV 107

Query: 142 NTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRG 201
           N EVVA SVDS F+HLAWINTPR+ GGLG + I LLSDLT QIS+DYGV LE SG  LRG
Sbjct: 108 NCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRG 167

Query: 202 LFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPA 261
           LFIID  G+++ +++NDLPVGRSV+ETLRLV+AFQY + HGEVCPA W P S TI P PA
Sbjct: 168 LFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPA 227

Query: 262 GKLKYFDKLN 271
              +YF K+N
Sbjct: 228 ASKEYFQKVN 237


>gi|33188454 peroxiredoxin 2 isoform c [Homo sapiens]
          Length = 142

 Score =  128 bits (321), Expect = 6e-30
 Identities = 59/89 (66%), Positives = 73/89 (82%), Gaps = 1/89 (1%)

Query: 79  AKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEF 138
           A+I KPAP ++ TAV+DG FKE+KL+DY+GKY+V FFYPLDFTFVCPTEIIAF +R E+F
Sbjct: 6   ARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDF 65

Query: 139 RSINTEVVACSVDSQFTHLAWINT-PRRQ 166
           R +  EV+  SVDSQFTHLAW    P+R+
Sbjct: 66  RKLGCEVLGVSVDSQFTHLAWYEQGPKRE 94


>gi|4758638 peroxiredoxin 6 [Homo sapiens]
          Length = 224

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 49/183 (26%), Positives = 81/183 (44%), Gaps = 14/183 (7%)

Query: 85  APYWEGTAVIDGEFKELKLTDYRG-KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINT 143
           AP +E    +      ++  D+ G  + + F +P DFT VC TE+        EF   N 
Sbjct: 11  APNFEANTTVG----RIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNV 66

Query: 144 EVVACSVDSQFTHLAW---INTPRRQGGLGPIRIPLLSDLTHQISKDYGVY----LEDSG 196
           +++A S+DS   HLAW   IN    +     +  P++ D   +++   G+      ++ G
Sbjct: 67  KLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKG 126

Query: 197 H--TLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSE 254
              T R +F+      L+   L     GR+ DE LR+V + Q T +     P  WK G  
Sbjct: 127 MPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDS 186

Query: 255 TII 257
            ++
Sbjct: 187 VMV 189


>gi|169205475 PREDICTED: similar to peroxiredoxin 6 [Homo sapiens]
          Length = 137

 Score = 33.1 bits (74), Expect = 0.26
 Identities = 16/48 (33%), Positives = 23/48 (47%)

Query: 112 VFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW 159
           + F +P D   VC  E+        EF   N +++A + DS   HLAW
Sbjct: 34  ILFSHPRDSKPVCTMELGRAAKLAPEFTKSNVKLIALATDSAEDHLAW 81


>gi|186928821 hepatoma-derived growth factor isoform c [Homo
           sapiens]
          Length = 233

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 1/53 (1%)

Query: 90  GTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSIN 142
           G AVID E  E  +     KY VFFF   +  F+ P ++  + +  E+F   N
Sbjct: 19  GAAVID-EMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPN 70


>gi|22748713 ankyrin repeat domain 9 [Homo sapiens]
          Length = 317

 Score = 29.6 bits (65), Expect = 2.9
 Identities = 18/40 (45%), Positives = 20/40 (50%), Gaps = 3/40 (7%)

Query: 9   ATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETE---ERPR 45
           A+ P   R RRLLLL LL    P GA      E   +RPR
Sbjct: 218 ASAPGEPRQRRLLLLDLLALYTPVGAAGSARQELLGDRPR 257


>gi|11055992 serine carboxypeptidase 1 precursor [Homo sapiens]
          Length = 452

 Score = 28.9 bits (63), Expect = 5.0
 Identities = 18/25 (72%), Positives = 18/25 (72%), Gaps = 1/25 (4%)

Query: 18 RRLLLLPLLLFLLPAGAVQGWETEE 42
          R LLLLPLLL L  AGAV  W TEE
Sbjct: 12 RWLLLLPLLLGL-NAGAVIDWPTEE 35


>gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens]
          Length = 240

 Score = 28.1 bits (61), Expect = 8.5
 Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 3/60 (5%)

Query: 83  KPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSIN 142
           K  P+W   A ID E  E  +     KY VFFF   +  F+ P ++  + +  E+F   N
Sbjct: 21  KGYPHWP--ARID-EMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPN 77


>gi|157502173 hypothetical protein LOC348487 [Homo sapiens]
          Length = 280

 Score = 28.1 bits (61), Expect = 8.5
 Identities = 20/51 (39%), Positives = 25/51 (49%), Gaps = 4/51 (7%)

Query: 211 LRQITLND-LPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDP 260
           L  I L D LP G S D++L   QAF       + CP+  +P S   IP P
Sbjct: 189 LESIYLQDSLPSGPSQDDSL---QAFSSPSPSPDSCPSPEEPPSTAGIPQP 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.141    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,338,967
Number of Sequences: 37866
Number of extensions: 508103
Number of successful extensions: 988
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 971
Number of HSP's gapped (non-prelim): 16
length of query: 271
length of database: 18,247,518
effective HSP length: 101
effective length of query: 170
effective length of database: 14,423,052
effective search space: 2451918840
effective search space used: 2451918840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.