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Search of human proteins with 54144654
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54144654 rhomboid protease 2 [Homo sapiens]
(303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54144654 rhomboid protease 2 [Homo sapiens] 608 e-174
gi|4506525 rhomboid protease 1 [Homo sapiens] 187 1e-47
gi|21264326 rhomboid protease 3 [Homo sapiens] 186 2e-47
gi|190341097 rhomboid family 1 [Homo sapiens] 65 6e-11
gi|93352558 rhomboid, veinlet-like 6 isoform 2 [Homo sapiens] 55 8e-08
gi|93352556 rhomboid, veinlet-like 6 isoform 1 [Homo sapiens] 55 8e-08
gi|4506527 rhodopsin [Homo sapiens] 34 0.18
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 32 0.91
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 32 0.91
gi|213385278 TNF receptor-associated factor 3 interacting protei... 32 0.91
gi|20070262 TNF receptor-associated factor 3 interacting protein... 32 0.91
gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide iso... 32 0.91
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 31 1.2
gi|4502559 calcium modulating ligand [Homo sapiens] 29 4.5
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 29 4.5
gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo s... 29 4.5
gi|237858799 adenylate kinase domain containing 1 isoform 1 [Hom... 29 5.9
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 29 5.9
gi|239756810 PREDICTED: hypothetical protein [Homo sapiens] 28 7.7
gi|239751292 PREDICTED: hypothetical protein XP_002347787 [Homo ... 28 7.7
gi|239745787 PREDICTED: hypothetical protein XP_002343554 [Homo ... 28 7.7
>gi|54144654 rhomboid protease 2 [Homo sapiens]
Length = 303
Score = 608 bits (1569), Expect = e-174
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MAAVHDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRG 60
MAAVHDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRG
Sbjct: 1 MAAVHDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRG 60
Query: 61 TYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEA 120
TYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEA
Sbjct: 61 TYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEA 120
Query: 121 WRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPL 180
WRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPL
Sbjct: 121 WRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPL 180
Query: 181 RYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFFVPE 240
RYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFFVPE
Sbjct: 181 RYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFFVPE 240
Query: 241 DGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLS 300
DGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLS
Sbjct: 241 DGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLS 300
Query: 301 PAN 303
PAN
Sbjct: 301 PAN 303
>gi|4506525 rhomboid protease 1 [Homo sapiens]
Length = 438
Score = 187 bits (475), Expect = 1e-47
Identities = 101/261 (38%), Positives = 159/261 (60%), Gaps = 7/261 (2%)
Query: 43 KKVHRIVSKWMLP-EKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWI-- 99
K+ R V+ +LP E R Y R PPPVF+ S++LA++ VF+ Y +W+
Sbjct: 167 KRFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGA--RLNKWVLQ 224
Query: 100 TLDTGILESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRV 159
T ++SP +Y P R AWRF++YM +H G++ + N +QL++G+PLEMVH LR+
Sbjct: 225 TYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRI 284
Query: 160 GLVYLAGVIAGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLI 219
L+YLAGV+AGSL SI D +VG SGGVYAL + NV++N+ M + + R+++
Sbjct: 285 SLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVL 344
Query: 220 IILIIVLDMGFALYRRFF--VPEDGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPR 277
++ + ++G A++ RF +P G SF AH+AG G+S+G T+ +++ L
Sbjct: 345 ALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCG 404
Query: 278 FWIAIAAYLACVLFAVFFNIF 298
+W+ + AY +LFAVF+N+F
Sbjct: 405 WWVVLLAYGTFLLFAVFWNVF 425
>gi|21264326 rhomboid protease 3 [Homo sapiens]
Length = 404
Score = 186 bits (472), Expect = 2e-47
Identities = 100/266 (37%), Positives = 162/266 (60%), Gaps = 5/266 (1%)
Query: 37 KDRAKSKKVHRIVSKWMLP-EKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQ 95
K + S+++ R V+ LP E R Y + C PPP F+I+++L E+A F+Y V Q
Sbjct: 127 KGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQ 186
Query: 96 KQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHK 155
L++ +Y P+ R + WR+++Y+ +HAG++H+ N+ +QL++G+PLEMVH
Sbjct: 187 FVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHG 246
Query: 156 GLRVGLVYLAGVIAGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIF 215
R+GLVY+AGV+AGSLA S+ D +VG+SGGVYAL+ + N+++N+ M F +
Sbjct: 247 ATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLL 306
Query: 216 RLLIIILIIVLDMGFALYRRFFVPEDGSPV---SFAAHIAGGFAGMSIGYTVFSCFDKAL 272
R+ + ++ + ++ G A++ RF P P SF AH+ G G+++G V +++ L
Sbjct: 307 RMAVALICMSMEFGRAVWLRFH-PSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRL 365
Query: 273 LKDPRFWIAIAAYLACVLFAVFFNIF 298
+WI +A Y VLFAVF+NIF
Sbjct: 366 QDQSLWWIFVAMYTVFVLFAVFWNIF 391
>gi|190341097 rhomboid family 1 [Homo sapiens]
Length = 855
Score = 65.5 bits (158), Expect = 6e-11
Identities = 38/154 (24%), Positives = 79/154 (51%), Gaps = 12/154 (7%)
Query: 109 PFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVI 168
PF+ +PE ++ +R + +HAG+ H L ++C Q+ + LE + R+ ++YL +
Sbjct: 643 PFL-NPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGV 701
Query: 169 AGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDM 228
G+LAS+IF P R VG +G + ++ F+ + ++Q + + F L+ +++ +
Sbjct: 702 TGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTF 761
Query: 229 GFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIGY 262
G + + AHI+G +G+ + +
Sbjct: 762 GLLPW-----------IDNFAHISGFISGLFLSF 784
>gi|93352558 rhomboid, veinlet-like 6 isoform 2 [Homo sapiens]
Length = 827
Score = 55.1 bits (131), Expect = 8e-08
Identities = 42/167 (25%), Positives = 78/167 (46%), Gaps = 17/167 (10%)
Query: 109 PFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVI 168
PF+ +PE ++ +R + +HAGV H L ++ Q+ + LE + R+ ++++ I
Sbjct: 615 PFL-NPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGI 673
Query: 169 AGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDM 228
G+LAS+IF P R VG +G + L+ F+ + ++ + + F L I++ +
Sbjct: 674 TGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFIC 733
Query: 229 GFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIG-----YTVFSCFDK 270
G + + AHI G +G+ + Y F DK
Sbjct: 734 GLLPW-----------IDNIAHIFGFLSGLLLAFAFLPYITFGTSDK 769
>gi|93352556 rhomboid, veinlet-like 6 isoform 1 [Homo sapiens]
Length = 856
Score = 55.1 bits (131), Expect = 8e-08
Identities = 42/167 (25%), Positives = 78/167 (46%), Gaps = 17/167 (10%)
Query: 109 PFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVI 168
PF+ +PE ++ +R + +HAGV H L ++ Q+ + LE + R+ ++++ I
Sbjct: 644 PFL-NPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGI 702
Query: 169 AGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDM 228
G+LAS+IF P R VG +G + L+ F+ + ++ + + F L I++ +
Sbjct: 703 TGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFIC 762
Query: 229 GFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIG-----YTVFSCFDK 270
G + + AHI G +G+ + Y F DK
Sbjct: 763 GLLPW-----------IDNIAHIFGFLSGLLLAFAFLPYITFGTSDK 798
>gi|4506527 rhodopsin [Homo sapiens]
Length = 348
Score = 33.9 bits (76), Expect = 0.18
Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 9/97 (9%)
Query: 103 TGILESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLV 162
TG++ SPF Y E W+F S + + + +LG L L + ++ HK LR L
Sbjct: 17 TGVVRSPFEYPQYYLAEPWQF-SMLAAYMFLLIVLGFPINFLTLYVTVQ--HKKLRTPLN 73
Query: 163 YLAGVIAGSLASSIFDPLRYLVGASGGVYALMGGYFM 199
Y+ L ++ D L G + +Y + GYF+
Sbjct: 74 YIL------LNLAVADLFMVLGGFTSTLYTSLHGYFV 104
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 31.6 bits (70), Expect = 0.91
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 6/47 (12%)
Query: 19 EMKEELEEEEKMREDG------GGKDRAKSKKVHRIVSKWMLPEKSR 59
E +EE EEEE+ E G G R K+KK R S W+ P + R
Sbjct: 313 EEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR 359
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 31.6 bits (70), Expect = 0.91
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 6/47 (12%)
Query: 19 EMKEELEEEEKMREDG------GGKDRAKSKKVHRIVSKWMLPEKSR 59
E +EE EEEE+ E G G R K+KK R S W+ P + R
Sbjct: 313 EEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR 359
>gi|213385278 TNF receptor-associated factor 3 interacting protein 1
isoform 2 [Homo sapiens]
Length = 625
Score = 31.6 bits (70), Expect = 0.91
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 6 DLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHR 47
D E++ + + R+ KEEL+E+ K RE K++AK +R
Sbjct: 170 DAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNR 211
>gi|20070262 TNF receptor-associated factor 3 interacting protein 1
isoform 1 [Homo sapiens]
Length = 691
Score = 31.6 bits (70), Expect = 0.91
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 6 DLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHR 47
D E++ + + R+ KEEL+E+ K RE K++AK +R
Sbjct: 170 DAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNR 211
>gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
isoform B [Homo sapiens]
Length = 353
Score = 31.6 bits (70), Expect = 0.91
Identities = 27/101 (26%), Positives = 40/101 (39%), Gaps = 6/101 (5%)
Query: 19 EMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISI 78
E KEE EEEEK E+G G+ + + L + R +L R F
Sbjct: 58 EEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGLILLIYFFFYA 117
Query: 79 SLAELAVFIYYAVWKPQKQWITLDT------GILESPFIYS 113
SLA + Y ++ +I T G++ PF +S
Sbjct: 118 SLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHS 158
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 31.2 bits (69), Expect = 1.2
Identities = 15/56 (26%), Positives = 33/56 (58%), Gaps = 4/56 (7%)
Query: 18 REMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPV 73
++ +++L++EE+ +++ KD+ +K R V++ M+P + E A PPP+
Sbjct: 355 KKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEK----EEAKLPPPPL 406
>gi|4502559 calcium modulating ligand [Homo sapiens]
Length = 296
Score = 29.3 bits (64), Expect = 4.5
Identities = 18/85 (21%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 5 HDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLE 64
H LE +++++L E+ +EDG + S ++ R+V +L R +
Sbjct: 150 HGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCK 209
Query: 65 RANCFPPPVFIISISLAELAVFIYY 89
+ F P +++ LA + ++ Y+
Sbjct: 210 YLSIFAP---FLTLQLAYMGLYKYF 231
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 29.3 bits (64), Expect = 4.5
Identities = 17/46 (36%), Positives = 27/46 (58%), Gaps = 3/46 (6%)
Query: 8 EMESMNLNMGREMKEELEEEEK---MREDGGGKDRAKSKKVHRIVS 50
E + NL+ R+++ ELEE E+ + E K R KS++VH +S
Sbjct: 1890 EQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935
>gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo
sapiens]
Length = 412
Score = 29.3 bits (64), Expect = 4.5
Identities = 11/26 (42%), Positives = 19/26 (73%)
Query: 15 NMGREMKEELEEEEKMREDGGGKDRA 40
N+G E +E+ EE+E+ RE+ G ++ A
Sbjct: 47 NVGAEEEEDAEEDEEKREEAGAEEEA 72
>gi|237858799 adenylate kinase domain containing 1 isoform 1 [Homo
sapiens]
Length = 1911
Score = 28.9 bits (63), Expect = 5.9
Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 4/50 (8%)
Query: 6 DLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLP 55
D E E+ + E+ EELEEEE+ G+D+ K +K H +K P
Sbjct: 892 DYEEETEDYQTEAEVDEELEEEEEEE----GEDKMKERKRHLGDTKHFCP 937
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 28.9 bits (63), Expect = 5.9
Identities = 18/48 (37%), Positives = 30/48 (62%), Gaps = 4/48 (8%)
Query: 8 EMESMNLNMGREMKEELEEEEK---MREDGGGKDRAKSKKVH-RIVSK 51
E ++NL+ R ++ ELEE E+ + E K R KS++VH +I+S+
Sbjct: 1891 EQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISE 1938
>gi|239756810 PREDICTED: hypothetical protein [Homo sapiens]
Length = 207
Score = 28.5 bits (62), Expect = 7.7
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 14/61 (22%)
Query: 124 ISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYL 183
+ +L+ V+H LG LC QL G L++ GLR L+S + +PL+YL
Sbjct: 126 LQLVLIQDDVKHFLGALC-QLFRGRYLDIEVFGLR-------------LSSGLDEPLKYL 171
Query: 184 V 184
V
Sbjct: 172 V 172
>gi|239751292 PREDICTED: hypothetical protein XP_002347787 [Homo
sapiens]
Length = 207
Score = 28.5 bits (62), Expect = 7.7
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 14/61 (22%)
Query: 124 ISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYL 183
+ +L+ V+H LG LC QL G L++ GLR L+S + +PL+YL
Sbjct: 126 LQLVLIQDDVKHFLGALC-QLFRGRYLDIEVFGLR-------------LSSGLDEPLKYL 171
Query: 184 V 184
V
Sbjct: 172 V 172
>gi|239745787 PREDICTED: hypothetical protein XP_002343554 [Homo
sapiens]
Length = 207
Score = 28.5 bits (62), Expect = 7.7
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 14/61 (22%)
Query: 124 ISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYL 183
+ +L+ V+H LG LC QL G L++ GLR L+S + +PL+YL
Sbjct: 126 LQLVLIQDDVKHFLGALC-QLFRGRYLDIEVFGLR-------------LSSGLDEPLKYL 171
Query: 184 V 184
V
Sbjct: 172 V 172
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.143 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,688,325
Number of Sequences: 37866
Number of extensions: 526593
Number of successful extensions: 2665
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2629
Number of HSP's gapped (non-prelim): 30
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.