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Search of human proteins with 50658071
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50658071 phosphodiesterase 4D interacting protein isoform 5
[Homo sapiens]
(1132 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 2208 0.0
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 1447 0.0
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 1447 0.0
gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 380 e-105
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 117 6e-26
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 117 6e-26
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 117 6e-26
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 117 6e-26
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 117 6e-26
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 117 6e-26
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 117 6e-26
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 117 6e-26
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 115 2e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 114 4e-25
gi|55770834 centromere protein F [Homo sapiens] 110 1e-23
gi|118498368 kinectin 1 isoform c [Homo sapiens] 109 1e-23
gi|118498362 kinectin 1 isoform b [Homo sapiens] 108 3e-23
gi|118498356 kinectin 1 isoform a [Homo sapiens] 107 5e-23
gi|33620775 kinectin 1 isoform a [Homo sapiens] 107 5e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 105 2e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 105 3e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 103 7e-22
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 103 9e-22
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 103 9e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 102 2e-21
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 101 4e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 101 4e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 101 5e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 101 5e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 101 5e-21
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [Homo
sapiens]
Length = 1132
Score = 2208 bits (5722), Expect = 0.0
Identities = 1132/1132 (100%), Positives = 1132/1132 (100%)
Query: 1 MKEICRICARELCGNQRRWIFHTASKLNLQVLLSHVLGKDVPRDGKAEFACSKCAFMLDR 60
MKEICRICARELCGNQRRWIFHTASKLNLQVLLSHVLGKDVPRDGKAEFACSKCAFMLDR
Sbjct: 1 MKEICRICARELCGNQRRWIFHTASKLNLQVLLSHVLGKDVPRDGKAEFACSKCAFMLDR 60
Query: 61 IYRFDTVIARIEALSIERLQKLLLEKDRLKFCIASMYRKNNDDSGAEIKAGNGTVDMSVL 120
IYRFDTVIARIEALSIERLQKLLLEKDRLKFCIASMYRKNNDDSGAEIKAGNGTVDMSVL
Sbjct: 61 IYRFDTVIARIEALSIERLQKLLLEKDRLKFCIASMYRKNNDDSGAEIKAGNGTVDMSVL 120
Query: 121 PDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDY 180
PDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDY
Sbjct: 121 PDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDY 180
Query: 181 EAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGS 240
EAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGS
Sbjct: 181 EAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGS 240
Query: 241 SVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLELALSMIKGLDY 300
SVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLELALSMIKGLDY
Sbjct: 241 SVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLELALSMIKGLDY 300
Query: 301 KPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQE 360
KPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQE
Sbjct: 301 KPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQE 360
Query: 361 LWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKI 420
LWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKI
Sbjct: 361 LWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKI 420
Query: 421 LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREM 480
LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREM
Sbjct: 421 LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREM 480
Query: 481 LHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ 540
LHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ
Sbjct: 481 LHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ 540
Query: 541 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 600
FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ
Sbjct: 541 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 600
Query: 601 HLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS 660
HLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS
Sbjct: 601 HLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFS 660
Query: 661 ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN 720
ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN
Sbjct: 661 ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN 720
Query: 721 LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELC 780
LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELC
Sbjct: 721 LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELC 780
Query: 781 QRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSEL 840
QRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSEL
Sbjct: 781 QRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSEL 840
Query: 841 QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSI 900
QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSI
Sbjct: 841 QALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSI 900
Query: 901 PRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADM 960
PRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADM
Sbjct: 901 PRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADM 960
Query: 961 ESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ 1020
ESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ
Sbjct: 961 ESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ 1020
Query: 1021 QLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRL 1080
QLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRL
Sbjct: 1021 QLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRL 1080
Query: 1081 EEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
EEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL
Sbjct: 1081 EEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [Homo
sapiens]
Length = 969
Score = 1447 bits (3747), Expect = 0.0
Identities = 761/768 (99%), Positives = 763/768 (99%)
Query: 365 LCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 424
L E+ + VQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK
Sbjct: 202 LLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
Query: 425 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 484
LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS
Sbjct: 262 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 321
Query: 485 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 544
QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA
Sbjct: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
Query: 545 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 604
AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH
Sbjct: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
Query: 605 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 664
SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE
Sbjct: 442 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
Query: 665 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 724
KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL
Sbjct: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
Query: 725 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 784
KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ
Sbjct: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
Query: 785 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 844
RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR
Sbjct: 622 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 681
Query: 845 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 904
QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST
Sbjct: 682 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 741
Query: 905 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 964
LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT
Sbjct: 742 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
Query: 965 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 1024
RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL
Sbjct: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
Query: 1025 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL
Sbjct: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 921
Query: 1085 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL
Sbjct: 922 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
Score = 78.6 bits (192), Expect = 3e-14
Identities = 132/597 (22%), Positives = 247/597 (41%), Gaps = 109/597 (18%)
Query: 543 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 591
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
Query: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLRQRIHD 646
++Q +H+ L +K QLLQE L + L E N L EKL
Sbjct: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKL------ 144
Query: 647 KAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRA 706
+ + + + + + + Q A+ +RD +E L L++ E
Sbjct: 145 ------KGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL---------- 188
Query: 707 KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC 766
VEQLS Q L L EE + Q E +++Q + + H+ + +S + L
Sbjct: 189 ----VEQLSREKQQLLHLLEEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 767 KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV-------LEHEMEIQGLLQSVSTRE 819
+L +E Q+ + ++LQ+ L++ + ++ + + IQ L +++ +RE
Sbjct: 243 EL--------QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
Query: 820 QESQAAAEKLVQALMERNSELQALRQ-----YLGGRDSLMSQAPISNQQAEVTPTGCL-G 873
+E+ E+L Q + +N + LR+ LG S +P Q A + L
Sbjct: 295 RET----EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
Query: 874 KQTDQGSMQIPSRDDSTSLT-AKEDVSIPRSTLGDLDTVAGLEKELS--NAKEELELMAK 930
Q + +Q R L AK+ V + + + +KE S + +E + + +
Sbjct: 351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ----QKEASWKHNQELRKALQQ 406
Query: 931 KERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQ--MQLVDPEDIP 988
+ E Q + L++ A + E++ Q +++ L ++ KE L+++ + +Q D D
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
Query: 989 ------AMERLTQEV--------LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
+E+L Q + + EK +++E + +E+ +QL L + +
Sbjct: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL-----RQLRLAVRERDHDLE 521
Query: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE-----LEGAQVLRSRLEEVLGR 1086
RL + L + S+ ES R + L+VE + Q L+ +E R
Sbjct: 522 RLRDVLSSNEATMQSM-------ESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 571
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 1447 bits (3747), Expect = 0.0
Identities = 761/768 (99%), Positives = 763/768 (99%)
Query: 365 LCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 424
L E+ + VQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK
Sbjct: 202 LLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
Query: 425 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 484
LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS
Sbjct: 262 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 321
Query: 485 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 544
QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA
Sbjct: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
Query: 545 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 604
AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH
Sbjct: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
Query: 605 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 664
SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE
Sbjct: 442 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
Query: 665 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 724
KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL
Sbjct: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
Query: 725 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 784
KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ
Sbjct: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
Query: 785 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 844
RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR
Sbjct: 622 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 681
Query: 845 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 904
QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST
Sbjct: 682 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 741
Query: 905 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 964
LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT
Sbjct: 742 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
Query: 965 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 1024
RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL
Sbjct: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
Query: 1025 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL
Sbjct: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 921
Query: 1085 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL
Sbjct: 922 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
Score = 78.6 bits (192), Expect = 3e-14
Identities = 132/597 (22%), Positives = 247/597 (41%), Gaps = 109/597 (18%)
Query: 543 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 591
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
Query: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLRQRIHD 646
++Q +H+ L +K QLLQE L + L E N L EKL
Sbjct: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKL------ 144
Query: 647 KAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRA 706
+ + + + + + + Q A+ +RD +E L L++ E
Sbjct: 145 ------KGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL---------- 188
Query: 707 KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC 766
VEQLS Q L L EE + Q E +++Q + + H+ + +S + L
Sbjct: 189 ----VEQLSREKQQLLHLLEEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 767 KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV-------LEHEMEIQGLLQSVSTRE 819
+L +E Q+ + ++LQ+ L++ + ++ + + IQ L +++ +RE
Sbjct: 243 EL--------QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
Query: 820 QESQAAAEKLVQALMERNSELQALRQ-----YLGGRDSLMSQAPISNQQAEVTPTGCL-G 873
+E+ E+L Q + +N + LR+ LG S +P Q A + L
Sbjct: 295 RET----EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
Query: 874 KQTDQGSMQIPSRDDSTSLT-AKEDVSIPRSTLGDLDTVAGLEKELS--NAKEELELMAK 930
Q + +Q R L AK+ V + + + +KE S + +E + + +
Sbjct: 351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ----QKEASWKHNQELRKALQQ 406
Query: 931 KERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQ--MQLVDPEDIP 988
+ E Q + L++ A + E++ Q +++ L ++ KE L+++ + +Q D D
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
Query: 989 ------AMERLTQEV--------LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
+E+L Q + + EK +++E + +E+ +QL L + +
Sbjct: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL-----RQLRLAVRERDHDLE 521
Query: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE-----LEGAQVLRSRLEEVLGR 1086
RL + L + S+ ES R + L+VE + Q L+ +E R
Sbjct: 522 RLRDVLSSNEATMQSM-------ESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 571
Score = 43.9 bits (102), Expect = 9e-04
Identities = 51/203 (25%), Positives = 94/203 (46%), Gaps = 25/203 (12%)
Query: 919 SNAKEELELMAKKERESQMELSALQSMMA-VQEEELQVQAADMESLTRNIQIKEDLIKDL 977
S E + + + R + + LQ+ ++ V E Q + E+L + ++L K+L
Sbjct: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950
Query: 978 QMQLVDPEDI-PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRL 1036
+ Q V+ + + + QEVL RE+ S++ + +R Q L++L+ +E+ +L
Sbjct: 1951 EHQKVERQQLLEDLREKQQEVLHFREERLSLQE-----NDSRLQHKLVLLQQQCEEKQQL 2005
Query: 1037 NEALQAERQLYS-------------SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE- 1082
E+LQ+E Q+Y SL H P SS+ L + + LR +LE+
Sbjct: 2006 FESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD----LSHLVAEVRALRGQLEQS 2061
Query: 1083 VLGRSLERLNRLETLAAIGGAAA 1105
+ G + RL + L + G A+
Sbjct: 2062 IQGNNCLRLQLQQQLESGAGKAS 2084
Score = 41.6 bits (96), Expect = 0.004
Identities = 64/312 (20%), Positives = 126/312 (40%), Gaps = 46/312 (14%)
Query: 598 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA--------- 648
++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 1830 SVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNF 1889
Query: 649 -----VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
++ + +E E+ + QL RE + E LR+ L S+ + +Q +E
Sbjct: 1890 YSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE 1949
Query: 704 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEVEDLSA 762
L + +E +QL L+ L+E K+QE + ++ + SL + + ++
Sbjct: 1950 LEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRLQHKLV 1993
Query: 763 TLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI---QGLLQSVSTRE 819
L Q E ++L + LQ + ++ + L + K + + ++ L +S
Sbjct: 1994 LL-----QQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLV 2048
Query: 820 QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 879
E +A +L Q++ N L+Q L S +P S Q TD G
Sbjct: 2049 AEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQN-------FPASTDPG 2101
Query: 880 SMQIPSRDDSTS 891
+ Q+ +D + S
Sbjct: 2102 NKQLLLQDSAVS 2113
Score = 36.6 bits (83), Expect = 0.14
Identities = 50/216 (23%), Positives = 86/216 (39%), Gaps = 36/216 (16%)
Query: 551 QQKEASWKHNQE---LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 607
Q S +H+QE LR+AL + LQ ++L + E+ Q L L
Sbjct: 1917 QLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVER-----------QQLLEDLR 1965
Query: 608 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEK 667
K+Q + FRE + L++ R+ K V L++ +EK E +
Sbjct: 1966 EKQQEVLHFRE--------------ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQS 2011
Query: 668 ELRQLRLAVRE-----RDHDLERLRDV-LSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 721
EL+ + + L+ + LSS+ + + + LR + LE C L
Sbjct: 2012 ELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQ-LEQSIQGNNCLRL 2070
Query: 722 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 757
Q L++++E+ + SI Q S NK++
Sbjct: 2071 Q-LQQQLESGAGKASLSPSSINQNFPASTDPGNKQL 2105
Score = 35.8 bits (81), Expect = 0.24
Identities = 37/155 (23%), Positives = 69/155 (44%), Gaps = 5/155 (3%)
Query: 382 LKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELK-CAQESSQ 440
L++Q + +T + + + ++ E I Q N++L+E + +L ++E SQ
Sbjct: 1868 LREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQ 1927
Query: 441 KQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQ 500
+ + +L+E L S +EL + +E Q +L E L + Q LH E Q+
Sbjct: 1928 ETE----SLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQE 1983
Query: 501 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 535
+ L + L Q E ++ Q E Q+ +A
Sbjct: 1984 NDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
Score = 34.3 bits (77), Expect = 0.69
Identities = 27/113 (23%), Positives = 58/113 (51%), Gaps = 7/113 (6%)
Query: 365 LCEDYLPLRV--QPMTEELLKQQKLNSHETTITQQSV--SDSHLAELQEKIQQTEATNKI 420
LC + LR + + +L + +S ET ++++ S SHL EL+++++ + +
Sbjct: 1900 LCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
Query: 421 LQEKLNEMSYELKCAQE---SSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 470
L E L E E+ +E S Q+ D +Q+ L+ + E ++L++ ++ +
Sbjct: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
Score = 33.9 bits (76), Expect = 0.90
Identities = 42/155 (27%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 894 AKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL-------------- 939
++E S+ + L + LEKEL + K E + + + RE Q E+
Sbjct: 1926 SQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND 1985
Query: 940 SALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI----KDLQMQLVDP-EDIPAMERLT 994
S LQ + + +++ + + ESL +QI E L K L+ +D IP L+
Sbjct: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLS 2045
Query: 995 QEVLLLREKVASVESQGQEISGNR--RQQLLLMLE 1027
V +R +E Q I GN R QL LE
Sbjct: 2046 HLVAEVRALRGQLE---QSIQGNNCLRLQLQQQLE 2077
Score = 32.7 bits (73), Expect = 2.0
Identities = 66/323 (20%), Positives = 128/323 (39%), Gaps = 43/323 (13%)
Query: 420 ILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER---ETEELY-QVIEGQNDTMA 475
+L+E L E+ + +ES D + L+ L S R T Y Q +E
Sbjct: 1843 LLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
Query: 476 KLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 535
+ R + ++ Q S + Q+ L+ AL S+ +Q+L++ + E Q +
Sbjct: 1903 ENRVLREDNRRLQAQLSHVSREHSQETE--SLREALLSSRSHLQELEK---ELEHQKVER 1957
Query: 536 KQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 595
+Q + E ++K+ H +E R +LQ+ LQ+K L+ EK +
Sbjct: 1958 QQLL--------EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESL 2009
Query: 596 EQNIQHLN------------------HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLL 637
+ +Q H + L E+ R +++++ N L
Sbjct: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR 2069
Query: 638 EKLRQRIHD---KAVALERAIDEKFSALEE---KEKELRQLRLAVRERDHDLERLRDVLS 691
+L+Q++ KA +I++ F A + K+ L+ ++ RD + V
Sbjct: 2070 LQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFP 2129
Query: 692 SNEATMQSMES--LLRAKGLEVE 712
S+ ++ E+ + RA GL ++
Sbjct: 2130 SSASSTPGSETPIINRANGLGLD 2152
>gi|169217489 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 211
Score = 380 bits (975), Expect = e-105
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 561 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 620
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
Query: 621 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 680
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
Query: 681 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 740
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
Query: 741 SIIQQLQTSLHDRNKEVE 758
SIIQQLQTSLHDRNKEVE
Sbjct: 182 SIIQQLQTSLHDRNKEVE 199
Score = 48.5 bits (114), Expect = 4e-05
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 459
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
Query: 460 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 517
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
Query: 518 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 577
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
Query: 578 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 621
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1355 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1401
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1402 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1455
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1512
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1513 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1632 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1857
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1858 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1909 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1959
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1960 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 2013 RLKAKVEEARRLRERA 2028
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 2002
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2241
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2242 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2353
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2354 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2404
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2405 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2450
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2497
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2498 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2553
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2554 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2450 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2619
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2620 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 864 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 923
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 924 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1034
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1095 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1194
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1195 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1363 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1530 EKQRALQALEELRLQA 1545
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1359 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1405
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1406 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1459
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1516
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1517 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1635
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1636 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1861
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1862 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1913 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1963
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1964 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 2017 RLKAKVEEARRLRERA 2032
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 2006
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2126
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2245
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2246 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2357
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2358 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2408
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2409 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2454
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2501
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2502 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2557
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2558 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2603
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2334 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2394 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2454 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2510
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2623
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2624 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 868 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 927
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 928 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 979
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 980 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1038
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1099 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1153 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1198
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1199 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1249
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1250 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1309
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1367 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1534 EKQRALQALEELRLQA 1549
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1355 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1401
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1402 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1455
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1512
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1513 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1632 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1857
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1858 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1909 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1959
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1960 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 2013 RLKAKVEEARRLRERA 2028
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 2002
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2241
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2242 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2353
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2354 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2404
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2405 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2450
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2497
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2498 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2553
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2554 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2450 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2619
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2620 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 864 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 923
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 924 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1034
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1095 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1194
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1195 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1246 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1305
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1363 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1530 EKQRALQALEELRLQA 1545
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1323 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1369
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1370 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1423
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1480
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1481 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1599
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1600 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1825
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1826 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1877 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1927
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1928 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 1981 RLKAKVEEARRLRERA 1996
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 1970
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2090
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2209
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2210 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2321
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2322 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2372
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2373 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2418
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2465
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2466 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2521
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2522 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2567
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2298 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2358 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2418 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2474
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2587
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2588 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 832 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 891
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 892 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 943
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 944 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1002
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1063 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1117 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1162
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1163 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1213
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1214 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1273
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1331 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1498 EKQRALQALEELRLQA 1513
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1492 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1538
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1539 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1592
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1649
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1650 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1768
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1769 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1994
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1995 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 2046 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 2096
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 2097 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 2150 RLKAKVEEARRLRERA 2165
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 2139
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2259
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2378
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2379 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2490
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2491 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2541
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2542 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2587
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2634
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2635 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2690
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2691 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2736
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2467 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2527 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2587 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2756
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2757 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 1001 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 1060
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 1061 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1112
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1171
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1232 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1286 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1331
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1332 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1382
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1383 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1442
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1500 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1667 EKQRALQALEELRLQA 1682
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1333 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1379
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1380 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1433
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1490
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1491 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1609
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1610 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1835
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1836 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1887 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1937
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1938 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 1991 RLKAKVEEARRLRERA 2006
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 1980
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2219
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2220 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2331
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2332 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2382
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2383 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2428
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2475
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2476 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2531
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2532 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2577
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2308 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2368 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2428 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2597
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2598 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 842 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 901
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 902 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 953
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 954 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1012
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1073 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1127 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1172
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1173 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1223
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1224 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1283
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1341 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1508 EKQRALQALEELRLQA 1523
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1341 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1387
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1388 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1441
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1498
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1499 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1617
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1618 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1843
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1844 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1895 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1945
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1946 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 1999 RLKAKVEEARRLRERA 2014
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 1988
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2108
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2227
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2228 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2339
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2340 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2390
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2391 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2436
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2483
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2484 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2539
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2540 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2585
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2316 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2376 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2435
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2436 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2492
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2605
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2606 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2657
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 850 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 909
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 910 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 961
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 962 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1020
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1081 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1135 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1180
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1181 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1231
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1232 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1291
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1349 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1516 EKQRALQALEELRLQA 1531
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 117 bits (293), Expect = 6e-26
Identities = 190/796 (23%), Positives = 337/796 (42%), Gaps = 107/796 (13%)
Query: 348 PVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTIT----QQSVSDSH 403
PV+ P + +Q + + ++Y+ LR L Q + T+ ++ +++
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
AE +E++ + EA + Q +L E + K E +E + ++R EE+
Sbjct: 1382 RAEERERLAEVEAALE-KQRQLAEAHAQAKAQAE------------REAKELQQRMQEEV 1428
Query: 464 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+ E D + R + Q +L QL S S A+ Q ++A S+L I++ R
Sbjct: 1429 VRREEAAVDAQQQKRSI--QEELQQLRQS---SEAEIQAKARQAEAAER-SRLRIEEEIR 1482
Query: 524 VVRQK----ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
VVR + ERQ A+ +Q + A A E+E QK + + + LR+ Q+Q+E Q K Q
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR---QVQDESQRKRQ 1539
Query: 580 -------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ--EFRELLQYRDNSDKTL 630
+++A EAE E + Q ++ L E+ L+ E Q + +
Sbjct: 1540 AEVELASRVKA-EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
Query: 631 EANEMLLEKLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDH---DL 683
+ E L+ R +K LER++ E+ A+ EE E+ +Q A R R+ +L
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1658
Query: 684 ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ-NLQWLKEEMETKFSRWQKEQESI 742
ER + L +NEA LR + EV Q + Q + KEE E + R K +E
Sbjct: 1659 ERWQ--LKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 743 IQQLQTSLHDRNKEVEDLSATLLCKL---------------GPGQSEIAEELCQRLQRKE 787
++Q + + + K+ + T +L G Q ++ EE RLQR+
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 788 RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 847
+ ++ + E++ LL S + E+ES++ +EK Q L + L +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
+L +A Q AE + + ++ + ++T L + ++++
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK------ 1884
Query: 908 LDTVAGLEKELSNAKEELELMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTR 965
EKE N E L +A+ E + ++E A Q ++E Q++ A L R
Sbjct: 1885 -------EKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
+ ED ++ Q + V+ E+I A++ ++ + A +E + I N L
Sbjct: 1936 QKGLVEDTLR--QRRQVE-EEILALKASFEKAAAGK---AELELELGRIRSNAEDTL--- 1986
Query: 1026 LEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER-DRTLQVELEGAQVLRSRLEEV- 1083
RS+ L+A RQ + + E+ ER ++L E E A+ ++ LEEV
Sbjct: 1987 -------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 1084 -LGRSLERLNRLETLA 1098
L +E RL A
Sbjct: 2040 RLKAKVEEARRLRERA 2055
Score = 94.7 bits (234), Expect = 4e-19
Identities = 143/714 (20%), Positives = 296/714 (41%), Gaps = 69/714 (9%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSY 430
R++ E+ L+ ++ E +Q ++ E +E++Q++ A + E +
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE-------EAAR 2029
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+ K A E ++ ++ + + E+E+ Q+ + + E H + Q
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
+ Q+Q L L+ ++ ++ + Q ER+ A +++ V+ E +E
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
Query: 551 QQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+Q +A + K ++ ++E ++Q +A +K E++ + +L K
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
Q+ QE L + +D + L++L+ + A + +E FS + E EL
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-ELS 2268
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
+L+ + + L LRD + + +Q ++ E +LS Q L++ E
Sbjct: 2269 KLKARIEAENRAL-ILRD-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR-KERM 789
++ + E ++++ ++ + + + +L Q E+A+E +RLQ KE+M
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAE------AELLQQQKELAQEQARRLQEDKEQM 2380
Query: 790 LQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG 849
Q Q+ E Q L++ R+ E A AE+L + E S QA +
Sbjct: 2381 AQ--------QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRAQARAEEDAQ 2431
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
R QA ++ T K T +++I + + D R +
Sbjct: 2432 R--FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLR------E 2477
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
+A LE+E ++E +L+ K E M VQ+E+L + ++L ++
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEE----------MQTVQQEQL---LQETQALQQSFLS 2524
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
++D + LQ + ++ +E+L Q+ + +++ + + Q+ RQ+L+ +E
Sbjct: 2525 EKDSL--LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME-- 2580
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL--EGAQVLRSRLE 1081
+ R R +EA + R+ L + E+ R Q EL E Q LR +L+
Sbjct: 2581 -EARRRQHEAEEGVRRKQEEL-------QQLEQQRRQQEELLAEENQRLREQLQ 2626
Score = 57.4 bits (137), Expect = 8e-08
Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 52/360 (14%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC----- 434
ELL+QQK + E Q + +L E+ Q + T + +++ EMS E +
Sbjct: 2357 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2416
Query: 435 ---------AQESSQKQDGTIQNLKETLKSRERETEE---LYQVIEGQNDTMAKLREMLH 482
A+E +Q+ + + E L E T+E L Q +E Q E L
Sbjct: 2417 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476
Query: 483 QSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ-- 540
++ + +L + QQ+ LL L+S + + Q LQ ++ L++ +Q
Sbjct: 2477 EA-IAELEREK--EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
Query: 541 -FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-------RAWEAEKYNEI 592
F+E + EQ + Q+LR+ Q+ Q++++ + Q+L R + E +
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 593 RTQEQNIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
R +++ +Q L +E+LL Q RE LQ + + A+ + +
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS-------EEVTASQ 2646
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS---NEATMQSMESLLR 705
VA + + AL+ E E +H + LR +S+ EA + S E L R
Sbjct: 2647 VAATKTLPNGRDALDGPAAE--------AEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
Score = 57.0 bits (136), Expect = 1e-07
Identities = 143/736 (19%), Positives = 281/736 (38%), Gaps = 97/736 (13%)
Query: 406 ELQEKIQQTEATNKILQEKLNEMSYELKCAQE-SSQKQDGTIQNLKETLKSRERETEELY 464
E QE + + EA ++ L +++ ++K S ++D + R + EE
Sbjct: 891 EAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 950
Query: 465 QVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 524
Q + E+ +Q+ L + G P + +A + S Q +Q L++
Sbjct: 951 QALHSL--------ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1002
Query: 525 VRQK---ERQLADAKQCVQFVEAAAHESEQQ------KEASWKHNQELRKALQQLQEELQ 575
+++ +R +++ K +EA + + KE + + Q + + Q+ Q E++
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ-QKAQAEVE 1061
Query: 576 N--KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE-- 631
K + EAEK + L L L++ R L KT+
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
Query: 632 ------ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 685
A E+L R H++ + +A+ LE + L++LR + +
Sbjct: 1122 IRGTQGAEEVL------RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
LRD L + + ++ + +EVE +W +E + RWQ +++ Q
Sbjct: 1176 LRDELRGAQEVGERLQQRHGERDVEVE---------RW-RERVAQLLERWQ----AVLAQ 1221
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEEL---CQRLQRKERMLQDLLSDRNKQVL 802
R +E+E L L E A+ L Q +R++ +Q + ++ V
Sbjct: 1222 TDV----RQRELEQLGRQLRY-----YRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1272
Query: 803 EHEMEIQGLLQSV---STREQESQAAAEKLVQALMERNSELQALRQYL------------ 847
E + Q LL+ + + +E Q A++ + A+ + +L + L
Sbjct: 1273 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1332
Query: 848 --GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
G + + +E+T L Q + + R + A++ + R L
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELT---TLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
Query: 906 GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME-SLT 964
+++ A LEK+ A+ + A+ ERE++ EL V+ EE V A + S+
Sbjct: 1390 AEVE--AALEKQRQLAEAHAQAKAQAEREAK-ELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 965 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQL 1022
+ Q+++ ++Q + E R+ +E+ ++R ++ + E Q G +
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 1023 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
E +R EA + RQ+ + S+R R +VEL +
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQV----------QDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 1083 VLGRSLERLNRLETLA 1098
R+L+ L L A
Sbjct: 1557 EKQRALQALEELRLQA 1572
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 115 bits (289), Expect = 2e-25
Identities = 171/788 (21%), Positives = 340/788 (43%), Gaps = 71/788 (9%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES 438
EE LK++ NS E H E Q Q T A + Q L ++ ++ +
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQH-QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVI---EGQNDTMAKLREMLH--QSQLGQL---- 489
Q + +Q KE + E+E E+LY I EG+ + +L+E H Q Q+ QL
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 490 -HSSEGTSPAQQQV--ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 546
+ SE AQ+ + + + ++ L +Q + L+ V + QL ++K+ V ++
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 547 HESEQ----QKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ-EQNIQH 601
+ + A +L+ L Q LQ+K Q+L N+I TQ +Q
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQVTAK 696
Query: 602 LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 661
L H QL +E + + ++ E E ++KL + + E+A+ +
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD---- 752
Query: 662 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 721
L+++ + L L E LE ++++SS +Q L + ++L+ +
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK---QKLTKQEEEK 809
Query: 722 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNK---EVEDLSATL------LCKLGPGQ 772
Q LK++ ET + + E + ++QT++ + K E E L L L K+
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL 869
Query: 773 SEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQA 832
E + Q+ + + DL ++ + L+H++++Q +++ ++E + + EK +A
Sbjct: 870 KNSKSEFEKENQKGKAAILDL--EKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEA 925
Query: 833 LMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSL 892
+ EL ++++ L + + Q QQ + L + ++Q QI + +
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE-LKQSSEQKKKQIEALQGELKI 984
Query: 893 TAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEE 952
+ + L A +EL+ KE++ ++ +SQ LQS +E E
Sbjct: 985 AVLQKTELENKLQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Query: 953 LQVQAADMESLTRNIQI-KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQG 1011
L D++S+ + + +EDLI + + Q+ + + ++ L L + A E Q
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKL--IQELKTAKATLEQDSAKKEQQL 1098
Query: 1012 QE---ISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQV 1068
QE + +++ L + LV+E+S+L E + + + + K + +S + + ++
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158
Query: 1069 -ELEGAQ--VLRSRLE-----EVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSI 1120
L+ A+ +++ +LE + L ++E+ R + + + E+ EF I
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK---DQVKKEEEELKKEF---I 1212
Query: 1121 EEEAAHHS 1128
E+EA HS
Sbjct: 1213 EKEAKLHS 1220
Score = 101 bits (251), Expect = 5e-21
Identities = 167/762 (21%), Positives = 314/762 (41%), Gaps = 85/762 (11%)
Query: 371 PLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSY 430
P V +EL QKL S +TQ++ + L E + + E L+EK NE S
Sbjct: 280 PQEVAVYVQEL---QKLKSSVNELTQKNQT------LTENLLKKEQDYTKLEEKHNEESV 330
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
K Q + ++D Q L+ L + E ++ + + + KL+E L + + H
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESE 550
QQQ + Q EI +L + + ERQL +A ++ + E
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQL--QSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
Query: 551 QQKEASWKHNQ-ELRKALQQLQEELQNKSQ---QLRAWEAEKYNEIRTQEQNIQHLNHSL 606
KE Q +L + +QL+E++ N ++ QL + + + Q+ L +
Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
Query: 607 SHKEQLLQEFRELLQYRDNSDKTLE---ANEMLLEKLRQRIHDKAVALE----------- 652
+ EQ+L++ + Q N + L+ N LLEK R+ ++ K A E
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
Query: 653 --RAIDEKFSALEEKEKELRQLRLAVRERDHD--------LERLRDVLSSNEATMQSMES 702
+ E+ + L EK K + +E HD L +D + S E ++ + S
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 703 LLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSA 762
L +V QL + L E + + + ++ + Q +L D+ +E+ ++
Sbjct: 629 QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 763 TLLCKLGPGQSEIAEELCQRLQRKER---MLQDLLSDRNKQVLEHEM---EIQGLLQSVS 816
L +++ +LQ K+ L+ L + ++ L E E++G ++ +
Sbjct: 689 QL------------DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 817 TREQESQAAAEKLVQALMER---NSELQ----ALRQYLGGRDSLMSQAPISNQQAEVTPT 869
E +A+ E+ +Q L ++ N++L+ L + L ++S + Q+
Sbjct: 737 ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALE 796
Query: 870 GCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEEL--EL 927
K T Q + + D +L+ + + TV L+K + KE L EL
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-VKMEKEALMTEL 855
Query: 928 MAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDI 987
K++ S++ S S ++E + +AA ++ E K+L+ QL
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD--------LEKTCKELKHQLQ----- 902
Query: 988 PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLY 1047
ME +E +E S+E + +E S + +L M E L+ ++ L + + E+QL
Sbjct: 903 VQMENTLKE---QKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 1048 SSLVKFHAHPESSERD-RTLQVELEGAQVLRSRLEEVLGRSL 1088
++ + E ++ LQ EL+ A + ++ LE L + L
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Score = 71.2 bits (173), Expect = 5e-12
Identities = 140/662 (21%), Positives = 289/662 (43%), Gaps = 73/662 (11%)
Query: 356 SDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK----- 410
S L+ + E YL L + TEEL Q K ++ + S + L +LQ++
Sbjct: 705 SQLESHLKEYKEKYLSL--EQKTEELEGQIKKLEADSLEVKAS-KEQALQDLQQQRQLNT 761
Query: 411 ---IQQTEATNKILQEK---------LNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 458
++ TE + ++ EK L + S L+ ++ KQ+ Q LK+ ++ +
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 459 ETEELYQVIEGQ-NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 517
ET+ ++ + + T+ +L+++ + + + T + + L + +L S+ E
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKE------ALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 518 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQ-------QL 570
+K + + K L K C + H+ + Q E + K +EL+K+L+ QL
Sbjct: 876 FEKENQ--KGKAAILDLEKTCKEL----KHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929
Query: 571 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 630
+ EL + +QL + N ++ E+ Q L +++ +Q ++ ++ ++ K
Sbjct: 930 KLELNSMQEQL----IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 631 EANEMLLE-KLRQRIHDKAVALERAIDEKFSAL----EEKEKELRQLRLAVRERDHDLER 685
+ LE KL+Q++ A L A EK S L E+ ++ +QL+ R+ +L
Sbjct: 986 VLQKTELENKLQQQLTQAAQEL-AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 686 LRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ 745
R L S E + + L + ++ + Q L+ K +E ++ KEQ+ +Q+
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK--KEQQ--LQE 1100
Query: 746 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHE 805
+L D KE + L L +EI E C++ + ++ ++L S + + + E
Sbjct: 1101 RCKALQDIQKE-KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE-I 1158
Query: 806 MEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQ--- 862
++ Q + ++ E Q A+ L A+ + Q L+ + + + + I +
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 863 QAEVTPTGCLGKQTDQG----SMQIPSRDDSTSLTAKE------DVSIPRSTLGDL-DTV 911
+E+ K+ ++ +MQI + +++ KE VS DL +
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
Query: 912 AGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTR---NIQ 968
A LE + N ++E + ++ + + E+ LQ+ + + +L A ++ L R ++Q
Sbjct: 1279 AVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Query: 969 IK 970
IK
Sbjct: 1339 IK 1340
Score = 45.1 bits (105), Expect = 4e-04
Identities = 103/484 (21%), Positives = 199/484 (41%), Gaps = 103/484 (21%)
Query: 692 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ--------------- 736
SN A + +LLR EV+ L + + +W EE++ + ++Q
Sbjct: 76 SNLALKRDDVTLLRQ---EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 737 --KEQESIIQQLQTSLHD--RNKEVEDL----SATLLCKLGPGQSEIAEE---------- 778
E +S+ QQL+ + + K+++DL +A L ++ +S+ EE
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 779 ---LCQRLQRKERMLQDLLSD-------RNKQVLEHEM-EIQGLLQSVS-TREQESQAAA 826
L + L ++ ++QDL ++ + VL+ E+ ++Q L+ +++ RE+ES+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 827 EKLVQ----------ALMERNSEL----QALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 872
++ + + + SEL Q + Y+ L S Q+ + L
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 873 GKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD-TVAGLEKELSNAKEELELMAKK 931
K+ D ++ ++S S K+++ ++TL D L+ LS ++ L + +
Sbjct: 313 KKEQDYTKLEEKHNEESVS---KKNI---QATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 932 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 991
E L+ ++ E + Q A+ + L + + KE LQ+Q
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ--HGLQLQ----------- 413
Query: 992 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDER----------SRLNEALQ 1041
E+ L K+ E Q E G ++Q L E L+D+ SRL E L+
Sbjct: 414 ---SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 1042 AE----RQLYSSLVKF-HAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLET 1096
+ +L L K H E ++ +L AQ + LE+VL + ++ +++
Sbjct: 471 EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ---NDLEQVLRQIGDKDQKIQN 527
Query: 1097 LAAI 1100
L A+
Sbjct: 528 LEAL 531
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 114 bits (286), Expect = 4e-25
Identities = 215/983 (21%), Positives = 424/983 (43%), Gaps = 135/983 (13%)
Query: 229 DGESMEEETPGSSVESLDASVQASPPQQ----KDEETERSAKELGKCDCC-SDDQAPQHG 283
DGE + E+ G+SV++L+ Q Q+ + +ET +S KE +C S+ +A Q
Sbjct: 267 DGEPVVED--GTSVKTLETLQQRVKRQENLLKRCKETIQSHKE--QCTLLTSEKEALQEQ 322
Query: 284 CNHKLELALSMIKGLDYKPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKP 343
+ +L+ L IK L + + L AK + + + +
Sbjct: 323 LDERLQ-ELEKIKDLHMAE---------KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 344 LYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSH 403
+++T E++ L+ + LR Q E ++L +T + +
Sbjct: 373 MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK 432
Query: 404 L-AELQEKIQQTEATNK----ILQEKLNEMSYEL-KCAQESSQKQDGTIQNLKETLKSRE 457
L AE+ E+I+ E T++ LQ++L+ + E+ ++SS++Q +Q L E K
Sbjct: 433 LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELA 490
Query: 458 RETEELYQVIEG-QNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQL 516
R+ +EL + ++ + + +++ L +SQ SE +Q++ + Q +L +L
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALEKSQ------SEYLKISQEK----EQQESLALEEL 540
Query: 517 EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW------------------- 557
E+QK + ++ + E +L D +Q + E E E S
Sbjct: 541 ELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 558 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN-IQHLNHSLSHKEQLLQEF 616
KHN+E+ +++ + EL++ Q A EK ++ Q Q ++ L +++ L +
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
Query: 617 RELL---QYRDNSDKTLE---ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
+E++ + ++KTLE + LE L + + A + ++E+ S L+++ +++
Sbjct: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-LEEELSVLKDQTDKMK 718
Query: 671 QLRLAV--RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKE-- 726
Q A +++H +++ ++ +E ++Q E L+ + ++E L + + LKE
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK--ERDKHLKEHQ 776
Query: 727 ------EMETKFSRWQKEQES----IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSE-- 774
E + K S + +Q S + Q Q++ H++ K E+ A L KL ++E
Sbjct: 777 AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERI 836
Query: 775 -----IAE------ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 823
+AE ++C L + +QDL+ KQ E E +++ L Q ++ ++
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 824 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 883
E+ Q L+E+ + + +R+ +++Q A+ L ++ +
Sbjct: 897 KEQEQTKQILVEKENMILQMREGQKKEIEILTQ----KLSAKEDSIHILNEEYETKFKNQ 952
Query: 884 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELS--- 940
+ + AKE + L LD A L+KEL N EL K+ +E++
Sbjct: 953 EKKMEKVKQKAKEMQETLKKKL--LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQAN 1010
Query: 941 ------ALQSMMAVQEEELQ-VQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERL 993
A+ + Q+E+++ + L I I E + +L + +I E+
Sbjct: 1011 SAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK- 1069
Query: 994 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF 1053
QEV L++K+ + +E++ +++ + E V + + LNE L L +
Sbjct: 1070 EQEVAELKQKILLFGCEKEEMN----KEITWLKEEGVKQDTTLNE-------LQEQLKQK 1118
Query: 1054 HAHPESSERDRT-LQVELEGAQVLRSRLEEVLGRSLERLNRL-ETLAAIGGAAAGDD--- 1108
AH S +D T L+ LE +LE L +SL+ L E L + A D
Sbjct: 1119 SAHVNSLAQDETKLKAHLE-------KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 1109 TEDTSTEFTDSIEEEAAHHSHQQ 1131
+E TS T E ++ SH++
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEK 1194
Score = 90.9 bits (224), Expect = 6e-18
Identities = 175/772 (22%), Positives = 312/772 (40%), Gaps = 120/772 (15%)
Query: 340 SLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSV 399
S++ L+++P+ L S +E V+ + E L + L+S + S
Sbjct: 71 SVESLFRSPIKESLFRSSSKESL-----------VRTSSRESLNRLDLDSSTASFDPPSD 119
Query: 400 SDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERE 459
DS E ++ + +++ NK ++ L+ + S G L + +RE
Sbjct: 120 MDS---EAEDLVGNSDSLNK------EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE 170
Query: 460 TEELYQVIEGQNDT----MAKLREMLHQSQLGQLHSSE----GTSPAQQQVALLDLQSAL 511
++L ++ D +A+LRE L Q + H E Q +++L Q +L
Sbjct: 171 KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230
Query: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQL- 570
+L + V + QL Q F + ES+ + + + + LQQ
Sbjct: 231 LKQRLRNGPMNVDVLKPLPQLEP--QAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
Query: 571 --QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD--NS 626
QE L + ++ E+ + ++++ +Q EQL + +EL + +D +
Sbjct: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQ---------EQLDERLQELEKIKDLHMA 339
Query: 627 DKT-----LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDH 681
+KT L + L+E+L Q DK + + + LE KE+E+ QLR +++
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQ---DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQ----WLKEEMETKFSRWQK 737
E LR+ +E RA E+E+ +T Q + LK EM+ + +K
Sbjct: 397 QGEELREQKEKSE----------RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 738 EQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR 797
E LQ L +EV D+ + +EE +LQ+
Sbjct: 447 TSEEERISLQQELSRVKQEVVDV-----------MKKSSEEQIAKLQKL----------H 485
Query: 798 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQA 857
K++ E E+ LQ TRE+E Q E++ AL + SE + Q ++SL +
Sbjct: 486 EKELARKEQELTKKLQ---TREREFQ---EQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 858 PISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKE 917
++A +T + K D R L + + S+ + D LE E
Sbjct: 540 LELQKKAILTESE--NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 918 LSNAKEELELMAKKERESQMELSALQSMMAVQEEELQV----QAADMESLTRNI-QIKED 972
+ +E+ +M +K + L Q A+ E+LQV +ME L Q KE
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQD--ALWTEKLQVLKQQYQTEMEKLREKCEQEKET 655
Query: 973 LIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISG--NRRQQLLLMLEGLV 1030
L+KD +++ I M T E L +++ +ES E+S R +L L L
Sbjct: 656 LLKD--KEIIFQAHIEEMNEKTLEKLDVKQ--TELESLSSELSEVLKARHKLEEELSVLK 711
Query: 1031 DERSRLNEALQAE--------RQLYSSLVKFH----AHPESSERDRTLQVEL 1070
D+ ++ + L+A+ +Q S++K H E + +D+ Q+EL
Sbjct: 712 DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Score = 85.1 bits (209), Expect = 3e-16
Identities = 190/885 (21%), Positives = 355/885 (40%), Gaps = 168/885 (18%)
Query: 354 ELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQ 413
ELS++ + L E+ L+ Q T+++ ++ + E Q DS + E + IQ+
Sbjct: 692 ELSEVLKARHKLEEELSVLKDQ--TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR 749
Query: 414 TEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEE------LYQVI 467
TE K L++++N++ LK + ++ ++NL+ +K E E ++ ++Q
Sbjct: 750 TE---KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY 806
Query: 468 EGQNDTMAKL-REMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQ--RV 524
+ K E L Q Q L +QVA ++ Q C++L+ K+Q +
Sbjct: 807 QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866
Query: 525 VRQKERQLADAKQCVQFV--------EAAAHESEQQKEASW-KHNQEL------RKALQQ 569
++Q E+Q ++ +Q V+ + E E EQ K+ K N L +K ++
Sbjct: 867 MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 570 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 629
L ++L K + E + + QE+ ++ + ++ L+ ++LL K
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK--KKLLDQEAKLKKE 984
Query: 630 LEANEMLLEKLRQRIHDKAVALERA----IDEKFSALEEKEKELRQLRLAVRERDHDLER 685
LE + L + ++ + K + + +A I + S LE +KE + V R+
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE----- 1039
Query: 686 LRDVLSSNEATM-QSMESL-------LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 737
L DV+S E + Q E L L+ K EV +L KEEM + + W K
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT-WLK 1098
Query: 738 E----QESIIQQLQTSLHDRNKEVE------------------DLSATL----------- 764
E Q++ + +LQ L ++ V DL+ +L
Sbjct: 1099 EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV 1158
Query: 765 -LCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNK------------QVLEHEMEIQ-- 809
L L EL +L+ + Q L S K + L E+ IQ
Sbjct: 1159 ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLD 1218
Query: 810 -------GLLQS---------------VSTREQESQAAAEKLVQALMERNSELQALRQYL 847
LL++ + +R Q K+ +AL+ + + L L
Sbjct: 1219 ICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPS-RDDSTSLTA------KEDVSI 900
+ IS QQA Q ++ QI S + D SL KE +
Sbjct: 1279 RQLTEEQNTLNISFQQAT--------HQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330
Query: 901 PRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ------ 954
++ + L+KELS + LM ++ +E ++E+S+L + +LQ
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS 1390
Query: 955 VQAADMESLTRNIQIKE----DLIKDLQMQL--VDPEDIPAME----------------- 991
+ A + SL + ++ D ++DL ++ + E I A+E
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 992 -RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQ-LYSS 1049
R TQ ++E +E + +E + + +Q+ L+ E L D++++ + L+ E + S
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKE-AYEKDEQINLLKEEL-DQQNKRFDCLKGEMEDDKSK 1508
Query: 1050 LVKFHAHPESSERDRTLQV-ELEGAQVLRSRLEEVLGRSLERLNR 1093
+ K ++ E+ + +T ++ ELE ++ E L L+ N+
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553
Score = 84.3 bits (207), Expect = 6e-16
Identities = 164/773 (21%), Positives = 304/773 (39%), Gaps = 174/773 (22%)
Query: 380 ELLKQ-QKLNSHETTITQQSVS--------DSHLAELQEKIQQTEATNKILQEKLNEMSY 430
ELL Q Q L+ T++++ +S + +E ++K Q + Q + E+
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH---QNTVKELQI 1465
Query: 431 ELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLH 490
+L+ + + ++D I LKE L + + + L +E M K L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE-------- 1517
Query: 491 SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHES 549
T Q +++L+ + +EI+ L V++ +Q + K+ VQ ++
Sbjct: 1518 ----TELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ------ 1567
Query: 550 EQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK 609
H QEL + +E + K L E+ T+++ ++H+N S+ K
Sbjct: 1568 ---------HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 610 EQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKE- 668
E+ L+ + L+ + L +L+++ K A+++ + S +EEKE++
Sbjct: 1619 EEELKALEDRLE---------SESAAKLAELKRKAEQKIAAIKKQL---LSQMEEKEEQY 1666
Query: 669 -------LRQLRLAVRERDHDL----ERLRDVLSSNEAT--------------------- 696
L +L ++ER+ ++ E+L+ V SS T
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 697 ------------------MQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR---W 735
+ E LL+ G E E+ ++ ++ +E K
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 736 QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLS 795
Q E +S+I LQ L ++NK+ + A + K G G++ I + ++ L+++
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG-GKNNI---------QAKQNLENVFD 1836
Query: 796 DRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLV-----QALMERNSELQALRQYLGGR 850
D K + E E+ Q L Q + +E +S +K V + L + +LQAL+Q + GR
Sbjct: 1837 DVQKTLQEKELTCQILEQKI--KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ-MDGR 1893
Query: 851 DSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD- 909
+ PT L + T++ S + L + +S + DL+
Sbjct: 1894 NK---------------PTELLEENTEEKS--------KSHLVQPKLLSNMEAQHNDLEF 1930
Query: 910 TVAGLEKELSNAKEELELMAKK----ERESQMELSALQSMMAVQEEELQVQAADMESLTR 965
+AG E+E +E+ + K +E Q EL L+ + EE Q + L
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
Query: 966 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLM 1025
N +K+ L+++ QL E +E +E + K VE++ E QLL
Sbjct: 1991 NSTLKQ-LMREFNTQLAQKEQ--ELEMTIKETI---NKAQEVEAELLESHQEETNQLLKK 2044
Query: 1026 L----EGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 1074
+ + L R E L A + E + + R LQ +LE Q
Sbjct: 2045 IAEKDDDLKRTAKRYEEILDAREE------------EMTAKVRDLQTQLEELQ 2085
Score = 57.8 bits (138), Expect = 6e-08
Identities = 115/546 (21%), Positives = 220/546 (40%), Gaps = 100/546 (18%)
Query: 383 KQQKLNSHETTITQQSVSDSHLAELQEKIQQT-EATNKILQEKLNEMSYELKCAQESSQK 441
K+++L + E + +S S + LAEL+ K +Q A K L ++ E + K ES
Sbjct: 1618 KEEELKALEDRL--ESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH-- 1673
Query: 442 QDGTIQNLKETLKSRERET----EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSP 497
+ L L+ RERE E+L V Q++T+ R ++ E S
Sbjct: 1674 ----LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSA--KNVAAYTEQEEADSQ 1727
Query: 498 AQQQVALLDLQSALFCSQLEIQKL-QRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 556
Q + S L + E +KL QRV ++KE ++ + + E + E +
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFE----MRCQYQERLIKLEHA 1783
Query: 557 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 616
E + + LQEEL+ K++ KY+ I Q + +++ K+ L F
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNK--------KYSLIVAQHVEKEGGKNNIQAKQNLENVF 1835
Query: 617 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAID-------------EKFSALE 663
D+ KTL+ E+ + L Q+I + L R + EK AL+
Sbjct: 1836 -------DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888
Query: 664 E-----KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 718
+ K EL + + + H ++ +LS+ EA +E L E ++L
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQP--KLLSNMEAQHNDLEFKLAGAEREKQKLGKEI 1946
Query: 719 ---------------QNLQWLK----EEMETKFSRWQKEQE--------SIIQQLQTSLH 751
Q L+ LK +E E K + Q++ E ++++ T L
Sbjct: 1947 VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLA 2006
Query: 752 DRNKEVE-----------DLSATLLCKLGPGQSEIAEELCQR---LQRKERMLQDLLSDR 797
+ +E+E ++ A LL +++ +++ ++ L+R + +++L R
Sbjct: 2007 QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAR 2066
Query: 798 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQA 857
+++ ++Q L+ + + Q+ E N + L+ L + +L+S +
Sbjct: 2067 EEEMTAKVRDLQTQLEELQKKYQQKLEQEEN----PGNDNVTIMELQTQLAQKTTLISDS 2122
Query: 858 PISNQQ 863
+ Q+
Sbjct: 2123 KLKEQE 2128
Score = 54.3 bits (129), Expect = 6e-07
Identities = 93/444 (20%), Positives = 180/444 (40%), Gaps = 77/444 (17%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYEL----KC 434
EE LK + + ET I +S + QE+ K +EK++ + L K
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 435 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND---TMAKLREMLHQ-------- 483
Q Q+++ T+ + E + +L Q++ + L+E L +
Sbjct: 1752 LQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI 1811
Query: 484 -SQLGQLHSSEGTSPAQQQVALL--DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ 540
+Q + + A+Q + + D+Q L +L Q L++ +++ + L K+ V
Sbjct: 1812 VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE-VH 1870
Query: 541 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ--------------------- 579
VE S+ +K + + K + L+E + KS+
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 580 QLRAWEAEKY---NEIRTQEQNIQHLNHSLSHKEQLLQ----EFRELLQYRDNSDKTLEA 632
+L E EK EI +++++ L + ++L+ + RE ++ D L+
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
Query: 633 NEMLLEKLRQ---RIHDKAVALERAIDEKFSALEEKEKEL--------RQLRLAVRERDH 681
N L + +R+ ++ K LE I E + +E E EL QL + E+D
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 741
DL+R T + E +L A+ E+++ ++LQ EE++ K+ + +++E+
Sbjct: 2051 DLKR----------TAKRYEEILDAR---EEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Query: 742 ------IIQQLQTSLHDRNKEVED 759
I +LQT L + + D
Sbjct: 2098 PGNDNVTIMELQTQLAQKTTLISD 2121
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 110 bits (274), Expect = 1e-23
Identities = 165/792 (20%), Positives = 325/792 (41%), Gaps = 129/792 (16%)
Query: 411 IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 470
+ Q +A N+ L+ K+NE+ L+ ++ + Q Q L+ L+ + E E +V+
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 471 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK----LQRVVR 526
D + + Q+ S++ T+ Q+ L L L C + + L++ ++
Sbjct: 340 RDELVRTTAQYDQA------STKYTALEQK---LKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 527 QKERQLADA------------KQCVQFVEAAAHESEQQKEASWKHNQELRKAL---QQLQ 571
+KE++ + ++C+Q E +Q K EL K QQL+
Sbjct: 391 EKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLE 450
Query: 572 EELQNKSQQL----RAWEAE--KYNEIRTQEQNIQHLNHSL-SHKEQLLQEFRELLQYRD 624
L+ Q+L +A++A K NE+R + ++ N+ L SH EQ +E L
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK 510
Query: 625 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV-------- 676
N + L ++ E+++ + + L R + EK + +E L +L+LAV
Sbjct: 511 NIKQCLNQSQNFAEEMKAKNTSQETML-RDLQEKINQ-QENSLTLEKLKLAVADLEKQRD 568
Query: 677 ------RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
++R+H +E+L D LS E +++ S L K E E+L +E +T
Sbjct: 569 CSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL-----------KEEKT 617
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKE--- 787
FS W+ E E ++ Q+++ + ++ L L Q + E +R++ E
Sbjct: 618 LFSCWKSENEKLLTQMESEKENLQSKINHLETCL-----KTQQIKSHEYNERVRTLEMDR 672
Query: 788 -------RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSEL 840
R L ++L ++ +V ++ L Q +Q+ Q E + + ++
Sbjct: 673 ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQV 732
Query: 841 QALRQYLG--GRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTA-KED 897
+ L L + + + AE L K D + + + D SL A +
Sbjct: 733 EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD--ASLVTNEDHQRSLLAFDQQ 790
Query: 898 VSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEE---ELQ 954
++ S + + E S + E + K Q + +L+ + Q++ +LQ
Sbjct: 791 PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQ 850
Query: 955 VQAADMESLTRNIQIKEDLIKDLQM----------------------QLVDPEDIPAMER 992
Q ++ + +I+E+L+K QM Q V E + A+E
Sbjct: 851 KQCEELVQIKG--EIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALEN 908
Query: 993 LTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVK 1052
+E+ LL +KV + +++ QE+ + +LE + E L+E L E++ SS++
Sbjct: 909 KEKELQLLNDKVETEQAEIQELKKSNH-----LLEDSLKELQLLSETLSLEKKEMSSIIS 963
Query: 1053 FHAHPESSERDRTLQVELEGAQVLRSRLEEV-LGRSLERLNRLETLAAIGGAAAGDDTED 1111
+ E+E L+E+ + E++N ++ + D+ E
Sbjct: 964 LNKR------------EIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI--DEREK 1009
Query: 1112 TSTEFTDSIEEE 1123
+ +E +D ++E
Sbjct: 1010 SISELSDQYKQE 1021
Score = 81.6 bits (200), Expect = 4e-15
Identities = 143/757 (18%), Positives = 310/757 (40%), Gaps = 118/757 (15%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES 438
EEL +QQ+ T+ Q+ + A L +++QQ + + +LQ +L+++ +
Sbjct: 398 EELSRQQRSFQ---TLDQECIQMK--ARLTQELQQAKNMHNVLQAELDKL---------T 443
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVIE-GQNDTMAKLREMLHQSQLGQLHSSEGTSP 497
S KQ ++N E K + E+ +Q + +N+ + EM ++ L + HS
Sbjct: 444 SVKQQ--LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS------ 495
Query: 498 AQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW 557
++ R V E +L + KQC+ + A E + + +
Sbjct: 496 ---------------------EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQE 534
Query: 558 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNE-----IRTQEQNIQHLNHSLSHKEQL 612
++L++ + Q + L + +L + EK + ++ +E +I+ LN LS E+
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 613 LQEFRELLQYRDNSDKTLEANEMLL-------EKLRQRIHDKAVALERAIDEKFSALEEK 665
+ L+ + + L+ + L EKL ++ + L+ I+ + L+ +
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 666 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK 725
+ + + VR + D E L ++++ ++L +K +EVE Q L +++
Sbjct: 655 QIKSHEYNERVRTLEMDRENL-------SVEIRNLHNVLDSKSVEVE-----TQKLAYME 702
Query: 726 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR 785
+ + +FS + ++E L+TS +VEDL L +L + + Q L
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTS--QLTGQVEDLEHKL--QLLSNEIMDKDRCYQDLHA 758
Query: 786 KERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 845
+ L+DLL ++ ++ +E + LL A ++ + +
Sbjct: 759 EYESLRDLLKSKDASLVTNEDHQRSLL-------------------AFDQQPAMHHSFAN 799
Query: 846 YLGGRDSLMSQAPISNQQAEVTP--TGCLGKQTDQGSMQIPSRDDSTSLTAKE------- 896
+G + S+ S+ +A+ +P + L + D + S+ S K+
Sbjct: 800 IIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI 859
Query: 897 ----DVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEE 952
+ ++ ++ VA + +S +E+ E+ L + + + ++
Sbjct: 860 KGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
Query: 953 LQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQG- 1011
++ + A+++ L ++ + ED +K+LQ+ L + + E + L RE + G
Sbjct: 920 VETEQAEIQELKKSNHLLEDSLKELQL-LSETLSLEKKEMSSIISLNKREIEELTQENGT 978
Query: 1012 -QEISGNRRQQLLLMLE------GLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDR 1064
+EI+ + Q+ + +++ +DER + L +++ L+ E+
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSISEL-SDQYKQEKLILLQRCEETGNAYE 1037
Query: 1065 TLQVELEGAQVLRSRLEEVLGRSL----ERLNRLETL 1097
L + + AQ S+LE +L R N LE L
Sbjct: 1038 DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074
Score = 80.5 bits (197), Expect = 8e-15
Identities = 154/780 (19%), Positives = 322/780 (41%), Gaps = 104/780 (13%)
Query: 356 SDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS---------DSHLAE 406
SDLQ+ CE+ + ++ + + E L+K ++++ T Q +S + +AE
Sbjct: 847 SDLQKQ----CEELVQIKGE-IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAE 901
Query: 407 LQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLKSRERETEEL 463
++ E ++L +K+ E++ ++S+ + +++ L+ ETL ++E +
Sbjct: 902 TLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSI 961
Query: 464 YQV-------IEGQNDTMAKLREMLHQSQLGQLHSSEGTSP----------------AQQ 500
+ + +N T+ ++ L+Q ++ + SE + Q+
Sbjct: 962 ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE 1021
Query: 501 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA-KQCVQFVEAAAHESEQQKEASWKH 559
++ LL + ++ + + ++K +L +C E +E EQ KEA K
Sbjct: 1022 KLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKE 1081
Query: 560 NQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL 619
+QE L +E QN +L + +E+ + N + L + L+E +
Sbjct: 1082 HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Query: 620 LQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 679
+Q N L+ NE L++ ++ + + + E ++++E+E E Q +
Sbjct: 1142 MQKEVND--LLQENEQLMKVMKTKHECQNLESEPI----RNSVKERESERNQCNF---KP 1192
Query: 680 DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ----NLQWLKEEMETKFSRW 735
DLE L S A + +E++LR K L++++ + LQ ++ ++ET +
Sbjct: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 736 QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLS 795
+ QE + L D + E+ + +L Q++ A C LQ L +L
Sbjct: 1253 MQSQEI------SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCS-LQTTMNKLNEL-- 1303
Query: 796 DRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMS 855
++ ++L+ E L+ ++ E A K+ + + + +E++ L G
Sbjct: 1304 EKICEILQAEK--YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSG------- 1354
Query: 856 QAPISNQQAEVTPTGCLGKQ-TDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT---V 911
+ + E P G G+Q +Q + + D+S S TL D +
Sbjct: 1355 --LLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESN--------SYEHLTLSDKEVQMHF 1404
Query: 912 AGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKE 971
A L+++ + + E +++ + + ++S LQ+ + + L+ + + + RN Q
Sbjct: 1405 AELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYV----DSLKAENLVLSTNLRNFQ--G 1458
Query: 972 DLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVD 1031
DL+K++Q+ L + +P+ L S + + + LL G +
Sbjct: 1459 DLVKEMQLGL-EEGLVPS----------LSSSCVPDSSSLSSLGDSSFYRALLEQTGDMS 1507
Query: 1032 ERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERL 1091
S L A+ A + + E+ R T +G + L S L EV +SLE+L
Sbjct: 1508 LLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELES-LCEVYRQSLEKL 1566
Score = 80.5 bits (197), Expect = 8e-15
Identities = 156/714 (21%), Positives = 284/714 (39%), Gaps = 121/714 (16%)
Query: 401 DSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERET 460
++ L+ ++ + E L+ L + E C ++ ++ + I L+E L E
Sbjct: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSER 1960
Query: 461 EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK 520
+L G+ DTM+K L Q +K
Sbjct: 1961 NQL----RGELDTMSKKTTALDQLS---------------------------------EK 1983
Query: 521 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQN---K 577
++ ++ E ++ C+Q EA E + + EL K LQE+LQ+
Sbjct: 1984 MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
Query: 578 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEAN---- 633
SQ L + E N+I + + L + E L E + N K LEA
Sbjct: 2044 SQALSLTKCELENQIAQLNKEKELL---VKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 634 ---EMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 690
+ L ++ +H L R I++ +E EK+ + ++ER+ + + L+D +
Sbjct: 2101 GEFALRLSSTQEEVHQ----LRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 691 SSNEATMQSMES-----LLRAKG--LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI- 742
+ E +Q E +L A+ EVE L T + + + E + E+E++
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216
Query: 743 --IQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQ 800
IQ+ Q L + +K + + L K Q+EI ++ + + MLQ+ L + N+
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEK---EQAEI--QIKEESKTAVEMLQNQLKELNEA 2271
Query: 801 V--LEHEMEI----QGLLQSVSTREQESQAAAEKLVQALMERNSE-----LQALRQYLGG 849
V L + EI + L E + + + EKL +A +E + + LQ L++
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL-RARLEADEKKQLCVLQQLKESEHH 2330
Query: 850 RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLD 909
D L + ++ E+ T Q S+ + +L AK + G
Sbjct: 2331 ADLLKGRVENLERELEIART----NQEHAALEAENSKGEVETLKAKIE--------GMTQ 2378
Query: 910 TVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQI 969
++ GLE ++ + E E + + ++ Q +S L+ + + E LQ E +Q+
Sbjct: 2379 SLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ------EKEQEKVQM 2432
Query: 970 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 1029
KE + AME L ++ L E+VA++ + QE + Q L +E L
Sbjct: 2433 KE-------------KSSTAMEMLQTQLKELNERVAALHND-QEACKAKEQNLSSQVECL 2478
Query: 1030 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV 1083
E+++L + L + Y L +SS +VE +G Q L + EE+
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVL-------QSSVNGLIQEVE-DGKQKLEKKDEEI 2524
Score = 79.7 bits (195), Expect = 1e-14
Identities = 151/709 (21%), Positives = 300/709 (42%), Gaps = 120/709 (16%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS 439
+L K+++L E+ Q +S+S EK+ ++A L EK E + L QE
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDY----EKLNVSKALEAALVEK-GEFALRLSSTQEEV 2114
Query: 440 QKQDGTIQNLKETLKSRERETEELYQVI---EGQNDTMAKLREMLHQSQLGQLHSSEGTS 496
+ I+ L+ +++ E++ + + + E +ND++ E L + +L SE
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER----ELQMSE--- 2167
Query: 497 PAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 556
Q++ +LD ++ S+ E++ L+ + + R L + + V + + K+
Sbjct: 2168 -ENQELVILDAEN----SKAEVETLKTQIEEMARSLKVFE--LDLVTLRSEKENLTKQIQ 2220
Query: 557 WKHNQ--ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ 614
K Q EL K L + L+ K Q E + E +T + +Q+ L+ L
Sbjct: 2221 EKQGQLSELDKLLSSFKSLLEEKEQA----EIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
Query: 615 EFRELLQYRDNS-DKTLEANEML---LEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
+E+++ + S D +E L +EKLR R+ A ++K + ++ KE
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE--------ADEKKQLCVLQQLKESE 2328
Query: 671 QLRLAVRERDHDLERLRDVLSSNE--ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEM 728
++ R +LER ++ +N+ A +++ S KG EVE L + + +
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENS----KG-EVETLKAKIEGMTQSLRGL 2383
Query: 729 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKER 788
E + E+E++ +LQ +R E+E ++++ ++ + E+ +++Q KE+
Sbjct: 2384 ELDVVTIRSEKENLTNELQKE-QERISELEIINSSF-------ENILQEKEQEKVQMKEK 2435
Query: 789 ------MLQDLLSDRNKQV--LEHEMEI-QGLLQSVSTREQESQAAAEKLVQALMERNSE 839
MLQ L + N++V L ++ E + Q++S++ + + +L+Q L E +
Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 840 LQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVS 899
L+ + G L ++ + G ++ +D+ S K +
Sbjct: 2496 YIVLQSSVNG----------------------LIQEVEDGKQKLEKKDEEIS-RLKNQIQ 2532
Query: 900 IPRSTLGDLDTVAGLEK-------ELSNAKEELE----LMAKKERESQMELSALQSMMAV 948
+ L V G + EL N ELE ++ K Q L LQS
Sbjct: 2533 DQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKN 2592
Query: 949 QEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVE 1008
E EL++ D S ++ + K+ ++Q +E+ + +K A ++
Sbjct: 2593 LENELELTKMDKMSFVE--KVNKMTAKETELQ--------------REMHEMAQKTAELQ 2636
Query: 1009 SQGQEISGNRRQ---QLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 1054
+E+SG + + +L L+LE + + +L E +L SL H
Sbjct: 2637 ---EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMH 2682
Score = 73.6 bits (179), Expect = 1e-12
Identities = 145/712 (20%), Positives = 279/712 (39%), Gaps = 79/712 (11%)
Query: 409 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 468
+KIQ+ E L+++ + ++L + + QKQ ++N K + +RE + L ++ E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 469 GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQK 528
T K+ L Q + Q++ EG L + +I+KL++ +++
Sbjct: 78 SLEKTKQKISHEL-QVKESQVNFQEG---------------QLNSGKKQIEKLEQELKRC 121
Query: 529 ERQLADAKQCVQFVEAAAHESEQQKEA-----------SWKHNQELRKALQQLQEELQNK 577
+ +L ++Q Q + + + ++ S ++L++ + EE +
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRL 181
Query: 578 SQQLRAWEAEKYNEIRTQEQNIQH---LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANE 634
+++A +A+K ++ Q + H H S Q+ + NS +T
Sbjct: 182 EAEVKALQAKKASQTLPQ-ATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT----- 235
Query: 635 MLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNE 694
+R+ + E+ + S L+ +++ H L++L+
Sbjct: 236 ----PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 695 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRN 754
+ +E L+ E++ Q LQ E+ + + E+E ++ + + L R
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI----EKEKVLNKCRDEL-VRT 346
Query: 755 KEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS 814
D ++T L ++ E+L + Q E L ++ E + E+ +S
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 815 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 874
T +QE +L Q L + + L+ L S+ Q + N E C +
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ--LENNLEEFKQKLCRAE 464
Query: 875 QTDQGSMQIPSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKELSNAKEEL------- 925
Q Q S QI + S+ KE+ + + V LE EL N K+ L
Sbjct: 465 QAFQAS-QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 926 ELMAKKERESQMELSALQSMMAVQE-----EELQVQAADMESLTRNIQIKEDLIKDLQMQ 980
E M K + L LQ + QE E+L++ AD+E + +DL+K +
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE---KQRDCSQDLLKKREHH 580
Query: 981 LVDPEDIPAMERLTQEVLL--LREKVASVESQGQEIS-----GNRRQQLLLMLEGLVDE- 1032
+ D + + LL L K E +E + + ++LL +E +
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL 640
Query: 1033 RSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
+S++N E L + +K H E +ER RTL+++ E V L VL
Sbjct: 641 QSKIN---HLETCLKTQQIKSH---EYNERVRTLEMDRENLSVEIRNLHNVL 686
Score = 68.6 bits (166), Expect = 3e-11
Identities = 98/455 (21%), Positives = 203/455 (44%), Gaps = 63/455 (13%)
Query: 383 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 442
K+Q L+S Q + A+L + + + + +LQ +N + E++ ++ +K+
Sbjct: 2467 KEQNLSS------QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520
Query: 443 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQV 502
D I LK ++ +E+ +L QV EG++ L + Q +L + T +Q++
Sbjct: 2521 DEEISRLKNQIQDQEQLVSKLSQV-EGEH--------QLWKEQNLELRNL--TVELEQKI 2569
Query: 503 ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAK-QCVQFVE----AAAHESEQQKEASW 557
+L ++A LE+ LQ + E +L K + FVE A E+E Q+E
Sbjct: 2570 QVLQSKNASLQDTLEV--LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM-- 2625
Query: 558 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS---------H 608
E+ + +LQEEL + +L EI++ + ++ L S H
Sbjct: 2626 ---HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMH 2682
Query: 609 KEQLLQEFR---ELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEK 665
K+Q+ +E + E+ +Y+ + + ++ LL ++ + + K L +
Sbjct: 2683 KDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ 2742
Query: 666 EKELRQLRLAVRERDHDLERLRDVLSSNEATM--------QSMESLLRAKGLEVEQLSTT 717
+ E+ L+ + E ++ L+ +L + T Q + RA+G +++ L +
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQG-KMKLLIKS 2801
Query: 718 CQNLQWLKEEMETKFSRWQ--KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI 775
C+ L+ KE ++ + S+ Q +E++ + T + + E+++L TL K E
Sbjct: 2802 CKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEA-DEY 2860
Query: 776 AEELC------QRLQRKERMLQ----DLLSDRNKQ 800
++ C ++L++ + ML+ L S ++KQ
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQ 2895
Score = 65.9 bits (159), Expect = 2e-10
Identities = 100/493 (20%), Positives = 212/493 (43%), Gaps = 71/493 (14%)
Query: 381 LLKQQKLNSHETTITQQSVS----DSHLAELQEKIQQTEATN-----KILQEKLNEMSYE 431
+L+Q K + H + + V + +A ++ EA N + L+ K+ M+
Sbjct: 2320 VLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS 2379
Query: 432 LKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHS 491
L+ + TI++ KE L + ++ +E +E N + + + Q ++ Q+
Sbjct: 2380 LR----GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV-QMKE 2434
Query: 492 SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ 551
T+ Q L +L + + Q + KE+ L+ +C++ +A +
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAA----LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLD 2490
Query: 552 QKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE---KYNEIRTQEQNIQHLNHSLSH 608
+ + ++ L+ ++ L +E+++ Q+L + E N+I+ QEQ + L+ +
Sbjct: 2491 EAKNNYI---VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS-QVEG 2546
Query: 609 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKE 668
+ QL +E + LE + +E +++K L+ K
Sbjct: 2547 EHQLWKE------------QNLELRNLTVE----------------LEQKIQVLQSKNAS 2578
Query: 669 LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVE-QLSTTCQNLQWLKEE 727
L+ ++ +LE ++ ++ + + + AK E++ ++ Q L+EE
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 728 METKFSRWQKEQESIIQQLQTS---LHDRNKEVEDLSATLLC-------KLGPGQSEIAE 777
+ + +R E + +++++++S L + E +L +L C K G + EIAE
Sbjct: 2639 LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAE 2698
Query: 778 ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ---ESQAAAEKLVQALM 834
RL E+ Q LL D NKQ +E+EIQ + ++++E+ + + L +
Sbjct: 2699 YQL-RLHEAEKKHQALLLDTNKQ---YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE 2754
Query: 835 ERNSELQALRQYL 847
E N+ L+A Q L
Sbjct: 2755 ELNNSLKATTQIL 2767
Score = 56.6 bits (135), Expect = 1e-07
Identities = 152/715 (21%), Positives = 276/715 (38%), Gaps = 143/715 (20%)
Query: 375 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 434
+P + +K+ L+S+ + Q ++ L + K+Q++E + LQ +L + +L
Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQL---EAMLRNKELKLQESEKEKECLQHELQTIRGDL-- 1245
Query: 435 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLH-----QSQLGQL 489
E+S QD Q + LK E + EE Y I G ++ + H Q+ + +L
Sbjct: 1246 --ETSNLQDMQSQEISG-LKDCEIDAEEKY--ISGPHELSTSQNDNAHLQCSLQTTMNKL 1300
Query: 490 HSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAH-- 547
+ E Q +L + L S+ E R + ++ +L + + + H
Sbjct: 1301 NELEKICEILQ-AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGE 1359
Query: 548 --ESEQQKEASWKHNQELRKALQQLQEE-------LQNKSQQLRAWEAEKYNEIRTQEQN 598
E E + N++ +L L E L +K Q+ E ++ E
Sbjct: 1360 LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419
Query: 599 IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLE-KLRQRIHDKAVALERAIDE 657
I H H Q+ + EL Y D+ L+A ++L LR D ++ ++E
Sbjct: 1420 ILHDQHC-----QMSSKMSELQTYVDS----LKAENLVLSTNLRNFQGDLVKEMQLGLEE 1470
Query: 658 KF-----SALEEKEKELRQLR-----LAVRERDHD---LERLRDVLSSNEATMQSM---- 700
S+ L L A+ E+ D L L +S+N+ ++ +
Sbjct: 1471 GLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSS 1530
Query: 701 ---ESLLR-------AKGLEVEQLSTTC----QNLQWLKEEMETKFSRWQKEQESIIQQL 746
E+L R AKG VE+L + C Q+L+ L+E+ME++ KE IQ+L
Sbjct: 1531 LQEENLTRKETPSAPAKG--VEELESLCEVYRQSLEKLEEKMESQGIMKNKE----IQEL 1584
Query: 747 QTSLHDRNKEVEDLSATLLCKLGPGQSEI-----------------AEELCQRLQRKERM 789
+ L +E++ L L + Q ++ E+L L+
Sbjct: 1585 EQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQ 1644
Query: 790 LQDL-LSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLG 848
LQ L LS R+ ++ E IQG +S ++ + E+ + + + + A
Sbjct: 1645 LQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDA------ 1698
Query: 849 GRDSLMSQAPISNQQAEVTPTG-CLGKQTDQGSMQIPSRDDSTSLT--------AKEDVS 899
+ L + V PTG C G+Q+ + + P D + + + +
Sbjct: 1699 -QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
Query: 900 IPRSTLGDLDTVAGLE---KELSN-------------AKEELELMAKKERESQMELSALQ 943
+P LG+ + + L+ KE SN K E L KE +S++ L +Q
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQ 1817
Query: 944 SMMAVQ-------------------EEELQVQAADMESLTRNIQIKEDLIKDLQM 979
M ++ E+L+ + D + L + ++ E L DL+M
Sbjct: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM 1872
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 109 bits (273), Expect = 1e-23
Identities = 168/806 (20%), Positives = 344/806 (42%), Gaps = 119/806 (14%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 412
++L + + W+++ + Y+ R E QQ L S ++ + L K+
Sbjct: 488 VQLQEAERRWEEV-QSYIRKRT---AEHEAAQQDLQSKFVA------KENEVQSLHSKLT 537
Query: 413 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND 472
T + + L+++L ++ + + +Q++ E ++ + + ++ + I Q
Sbjct: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
Query: 473 TMAKLREMLHQ------SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
L E LH+ Q+ Q +SE ++ L D+Q+ F + E+QKLQ
Sbjct: 598 ASV-LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 524 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 583
+ ++ AAAHE E+ +++ + + ++R +QLQ E+ NK ++ +
Sbjct: 657 LANEQA--------------AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 584 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 643
++ ++++ Q +Q L +K+ ++++ + +Q +D KT+E LLE +
Sbjct: 703 LN-DQNKALKSEVQKLQTLVSEQPNKD-VVEQMEKCIQEKDEKLKTVEE---LLETGLIQ 757
Query: 644 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
+ K L AI + S+L ++ ++L+ + +E L+ V+ + ++S+E L
Sbjct: 758 VATKEEEL-NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 704 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ------ESIIQQLQTSLHDRNKEV 757
L A+ L+V T Q+L+ + ++ + Q E+ S +Q+LQ L + +++
Sbjct: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
Query: 758 EDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 817
+ A L EE + L + LQD L + N+ + H E+ +
Sbjct: 877 NTMKAVL------------EEKEKDLANTGKWLQD-LQEENESLKAHVQEV----AQHNL 919
Query: 818 REQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE------VTPTGC 871
+E S + E+L L E+ +EL+ L L R+S +S Q + +
Sbjct: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
Query: 872 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 931
L +Q Q + P ++ + ++ + I +GL EL + K+ +E KK
Sbjct: 980 LKQQNYQQASSFPPHEELLKVISEREKEI-----------SGLWNELDSLKDAVEHQRKK 1028
Query: 932 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDL------IKDLQMQLVDPE 985
E Q ++ A++ ++ +E+ + S+ N+ E L K+ E
Sbjct: 1029 NNERQQQVEAVE----LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1084
Query: 986 DIPAMERLTQEV----LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE-----RSRL 1036
++ +E +E LL+ + +S E G +L L+ V++ + ++
Sbjct: 1085 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG-----ILQKLQRSVEQEENKWKVKV 1139
Query: 1037 NEALQAERQLYSSLVKFHAHPE---SSERD--------RTLQVELEGAQVLRS----RLE 1081
+E+ + +Q+ SS E S +D L++ELE A++ RS +
Sbjct: 1140 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1199
Query: 1082 EVLGRSLERLNRLETLAAIGGAAAGD 1107
E+ + E L +L T AGD
Sbjct: 1200 ELKAQLNETLTKLRTEQNERQKVAGD 1225
Score = 88.6 bits (218), Expect = 3e-17
Identities = 189/961 (19%), Positives = 382/961 (39%), Gaps = 188/961 (19%)
Query: 231 ESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLEL 290
ES + PG VE + + Q +PP + ++ ++ K SDDQ + K+E
Sbjct: 132 ESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG--SDDQ------DKKVET 183
Query: 291 ALSMIKGLDYKPIQSPRGSRLPI---PVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKT 347
+ + S R LP+ + S G K S + F++ +PL
Sbjct: 184 LM----------VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVD---EPLIHA 230
Query: 348 PVSYPL-------ELSDLQELWDDLCED-----------------------------YLP 371
PL + D +E+ D L D L
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 372 LRVQPMTE-ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKIL--------- 421
L+ +E E L L ++ + Q ++ S EL I Q + +K+L
Sbjct: 291 LKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA 350
Query: 422 -QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL-------YQVIEGQNDT 473
+++ +++ E+ +E S + I +K+ + + E+E YQ +
Sbjct: 351 TKDRCKQLTQEMMTEKERS---NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
Query: 474 MAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++RE + ++++ L G L+S E+ KL++ + +L
Sbjct: 408 FQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESK---QSAELNKLRQDYARLVNELT 463
Query: 534 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 593
+ +Q E +EQ QE + +++Q ++ ++ + A + + ++
Sbjct: 464 EKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV 523
Query: 594 TQEQNIQHLNHSLS----HKEQLLQEFRELL---QYRDNSDKT--------LEANEMLLE 638
+E +Q L+ L+ K+QL Q +L+ Q R N +++ LE NE L
Sbjct: 524 AKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 639 KLRQRIHDKAVALERA---IDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 695
++ Q+ H + A A +E + EK+K+++Q + L RD L+S E
Sbjct: 584 QI-QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-------TEDSLASERDRLTSKEE 635
Query: 696 TM---QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 752
+ Q+M LL+A+ Q LQ L E +K Q+S+
Sbjct: 636 ELKDIQNMNFLLKAE----------VQKLQALANEQAAAAHELEKMQQSVY--------- 676
Query: 753 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 812
V+D LL + ++ E+ +++ + +L+D+NK + ++Q L+
Sbjct: 677 ----VKDDKIRLL------EEQLQHEISNKMEEFK-----ILNDQNKALKSEVQKLQTLV 721
Query: 813 QSVSTREQESQAAAEKLVQALMERNSELQALRQYL-------GGRDSLMSQAPISNQQAE 865
EQ ++ E++ + + E++ +L+ + + L ++ ++ N
Sbjct: 722 S-----EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 866 VTPTGCLGKQTDQGSMQIPSRDDSTSLTAKED--VSIPRSTLGDLDTVAGLEKELSNAKE 923
KQ DQ S + + K+ S+ +L VA EK + + K+
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 924 ELELMAKK------ERESQMELSA----LQSMMAVQEEELQVQAADMESLTRNIQIKEDL 973
E++ + ++ E+ Q+ +++ LQ+++ +EE++ A +E +++
Sbjct: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
Query: 974 IKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ--EISGNRRQQLLLMLEGLVD 1031
++DLQ E+ +++ QEV K AS SQ + EI ++ L LE ++
Sbjct: 897 LQDLQ------EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 1032 ER-------SRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
ER ++L + +Q E +L+ S ++ ++ ++ + E +V+ R +E+
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEIS 1009
Query: 1085 G 1085
G
Sbjct: 1010 G 1010
Score = 66.2 bits (160), Expect = 2e-10
Identities = 170/902 (18%), Positives = 374/902 (41%), Gaps = 120/902 (13%)
Query: 313 IPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPL 372
IP K+ A+ + + +G L+ S V +LSD + DD +PL
Sbjct: 48 IPTKTDKKKAEKKKNKKKEIQNGNLHES----DSESVPRDFKLSDALAVEDDQVAP-VPL 102
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSV-SDSHLAELQ----EKIQQTEATNKILQEKLNE 427
V + + +++K + + ++ V +S +++ E + T+ + ++
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 428 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE-----GQNDTMAKLRE--- 479
K ++ S QD ++ L + S+ +E L+Q + G+ +K ++
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
Query: 480 ------MLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++H + L + +SP + ++DL ++ +++ + +++ A
Sbjct: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
Query: 534 DAK--------QCVQFVE-AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQ 580
+ K + + F E A + KE S L+K+ L L +LQ K +
Sbjct: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
Query: 581 LRAWEAEKY----------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN-SDKT 629
L A + + E+ T+++ + + + L++ + Q + + S +
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 630 LEANEMLLEKLRQRIHDKAVALER-------AIDEKFSALEEKEK-ELRQLRLAVRERDH 681
+ +M +++R+++ + L++ A+ + LE K+ EL +LR
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR-------Q 453
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 741
D RL + L+ +Q E + QL Q + EE+++ + E E+
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
Query: 742 IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 801
Q LQ+ + EV+ L S++ + L + Q ++R++Q L+ K+V
Sbjct: 514 AQQDLQSKFVAKENEVQSL-----------HSKLTDTLVSKQQLEQRLMQ-LMESEQKRV 561
Query: 802 LEHE---MEIQGLLQ-----SVSTREQESQAAAEKLVQALMERNSELQAL--RQYLGGRD 851
+ E M++Q +L+ ++ SQ AA+ L E ++ A +Q D
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 852 SLMSQAP-ISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
SL S+ +++++ E+ + ++ + + + A E + +S D
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 911 VAGLEK----ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRN 966
+ LE+ E+SN EE +++ + + + E+ LQ++++ Q + V E + +
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV-----EQMEKC 736
Query: 967 IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 1026
IQ K++ +K ++ +L++ I + +E+ +R + +S+ + Q++ + Q +
Sbjct: 737 IQEKDEKLKTVE-ELLETGLIQVATK-EEELNAIRTENSSLTKEVQDLKAKQNDQ--VSF 792
Query: 1027 EGLVDERSRL-----NEALQAERQLYSSLVKFHAHPESSERDRTLQ----------VELE 1071
LV+E ++ + E L + L+K A+ E + +D + V+LE
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKV-ANKEKTVQDLKQEIKALKEEIGNVQLE 851
Query: 1072 GAQVL--RSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSH 1129
AQ L S+++E+ + ++ T+ A+ D +T D EE + +H
Sbjct: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAV-LEEKEKDLANTGKWLQDLQEENESLKAH 910
Query: 1130 QQ 1131
Q
Sbjct: 911 VQ 912
Score = 35.4 bits (80), Expect = 0.31
Identities = 39/190 (20%), Positives = 89/190 (46%), Gaps = 18/190 (9%)
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
L +LQ ++Q E K+ ++ ++ +++ + SS+++ +++ + +++ RE E L
Sbjct: 1121 LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1180
Query: 464 YQVIEG----QNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQ 519
+E ++ + ++RE+ ++QL + + T ++Q DL A Q
Sbjct: 1181 EMELEKAEMERSTYVTEVREL--KAQLNETLTKLRTEQNERQKVAGDLHKA--------Q 1230
Query: 520 KLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
+ +++ K + A ++ + + +KE + L + + QLQ+ LQ +Q
Sbjct: 1231 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM---SVSLNQTVTQLQQLLQAVNQ 1287
Query: 580 QLRAWEAEKY 589
QL E E Y
Sbjct: 1288 QLTK-EKEHY 1296
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 108 bits (270), Expect = 3e-23
Identities = 180/812 (22%), Positives = 349/812 (42%), Gaps = 127/812 (15%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 412
++L + + W+++ + Y+ R E QQ L S ++ + L K+
Sbjct: 488 VQLQEAERRWEEV-QSYIRKRT---AEHEAAQQDLQSKFVA------KENEVQSLHSKLT 537
Query: 413 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND 472
T + + L+++L ++ + + +Q++ E ++ + + ++ + I Q
Sbjct: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
Query: 473 TMAKLREMLHQ------SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
L E LH+ Q+ Q +SE ++ L D+Q+ F + E+QKLQ
Sbjct: 598 ASV-LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 524 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 583
+ ++ AAAHE E+ +++ + + ++R +QLQ E+ NK ++ +
Sbjct: 657 LANEQA--------------AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 584 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 643
++ ++++ Q +Q L +K+ ++++ + +Q +D KT+E LLE +
Sbjct: 703 LN-DQNKALKSEVQKLQTLVSEQPNKD-VVEQMEKCIQEKDEKLKTVEE---LLETGLIQ 757
Query: 644 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
+ K L AI + S+L ++ ++L+ + +E L+ V+ + ++S+E L
Sbjct: 758 VATKEEEL-NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 704 LRAKGLEVE------QLSTT-----CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 752
L A+ L+V QLS T QNL KEE +E+E + L D
Sbjct: 817 LEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQD 876
Query: 753 RNKEVEDLSATLL------CKLGPGQSEIAE------ELCQRLQRKERMLQDLLSDRNK- 799
+E E L A + K S+ E E L+R E ML++ SD +
Sbjct: 877 LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 936
Query: 800 -QVLEHEMEIQGLLQS--VSTREQESQAAA-----EKLVQALMERNSELQALRQYLGG-R 850
Q+L+ + L +S ++Q Q A+ E+L++ + ER E+ L L +
Sbjct: 937 TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK 996
Query: 851 DSLMSQAPISN---------QQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE----- 896
D++ Q +N +A + L + ++ S + + ++ L AKE
Sbjct: 997 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1056
Query: 897 --DVSIPRSTLGDLDTVAGLEKEL------SNAKEELELMAKKERES-------QMELSA 941
VS+P S L + + G EK+ ++ EE++++ K +E+ Q+E
Sbjct: 1057 FPKVSVP-SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEK 1115
Query: 942 LQSMMAVQEEELQVQAADMESLTRNIQIKED----LIKDLQMQLVDPEDIPAMERLTQEV 997
+S++A E LQ +E ++K D IK +Q E QE+
Sbjct: 1116 YKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE---------QEL 1166
Query: 998 LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR-LNEALQAERQLYSSLVKFHAH 1056
LR + +E+ +E R+ L + LE ERS + E + + QL +L K
Sbjct: 1167 ERLRSENKDIENLRRE-----REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRT- 1220
Query: 1057 PESSERDRT---LQVELEGAQVLRSRLEEVLG 1085
E +ER + L + ++++S++ + G
Sbjct: 1221 -EQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1251
Score = 86.3 bits (212), Expect = 2e-16
Identities = 186/946 (19%), Positives = 379/946 (40%), Gaps = 181/946 (19%)
Query: 231 ESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLEL 290
ES + PG VE + + Q +PP + ++ ++ K SDDQ + K+E
Sbjct: 132 ESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG--SDDQ------DKKVET 183
Query: 291 ALSMIKGLDYKPIQSPRGSRLPI---PVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKT 347
+ + S R LP+ + S G K S + F++ +PL
Sbjct: 184 LM----------VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVD---EPLIHA 230
Query: 348 PVSYPL-------ELSDLQELWDDLCED-----------------------------YLP 371
PL + D +E+ D L D L
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 372 LRVQPMTE-ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKIL--------- 421
L+ +E E L L ++ + Q ++ S EL I Q + +K+L
Sbjct: 291 LKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA 350
Query: 422 -QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL-------YQVIEGQNDT 473
+++ +++ E+ +E S + I +K+ + + E+E YQ +
Sbjct: 351 TKDRCKQLTQEMMTEKERS---NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
Query: 474 MAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++RE + ++++ L G L+S E+ KL++ + +L
Sbjct: 408 FQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESK---QSAELNKLRQDYARLVNELT 463
Query: 534 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 593
+ +Q E +EQ QE + +++Q ++ ++ + A + + ++
Sbjct: 464 EKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV 523
Query: 594 TQEQNIQHLNHSLS----HKEQLLQEFRELL---QYRDNSDKT--------LEANEMLLE 638
+E +Q L+ L+ K+QL Q +L+ Q R N +++ LE NE L
Sbjct: 524 AKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 639 KLRQRIHDKAVALERA---IDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 695
++ Q+ H + A A +E + EK+K+++Q + L RD L+S E
Sbjct: 584 QI-QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-------TEDSLASERDRLTSKEE 635
Query: 696 TM---QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 752
+ Q+M LL+A+ Q LQ L E +K Q+S+
Sbjct: 636 ELKDIQNMNFLLKAE----------VQKLQALANEQAAAAHELEKMQQSVY--------- 676
Query: 753 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 812
V+D LL + ++ E+ +++ + +L+D+NK + ++Q L+
Sbjct: 677 ----VKDDKIRLL------EEQLQHEISNKMEEFK-----ILNDQNKALKSEVQKLQTLV 721
Query: 813 QSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 872
EQ ++ E++ + + E++ +L+ + + L ++ + Q ++ T
Sbjct: 722 S-----EQPNKDVVEQMEKCIQEKDEKLKTVEELL---ETGLIQVATKEEELNAIRTENS 773
Query: 873 GKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKE 932
+ ++ D + + E++ + + + D +EL A EL +A KE
Sbjct: 774 SLTKEVQDLKAKQNDQVSFASLVEEL---KKVIHEKDGKIKSVEELLEA--ELLKVANKE 828
Query: 933 RESQMELSA----LQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIP 988
+ Q+ +++ LQ+++ +EE++ A +E +++ ++DLQ E+
Sbjct: 829 KTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ------EENE 882
Query: 989 AMERLTQEVLLLREKVASVESQGQ--EISGNRRQQLLLMLEGLVDER-------SRLNEA 1039
+++ QEV K AS SQ + EI ++ L LE ++ ER ++L +
Sbjct: 883 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 942
Query: 1040 LQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLG 1085
+Q E +L+ S ++ ++ ++ + E +V+ R +E+ G
Sbjct: 943 VQDENKLFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEISG 987
Score = 65.5 bits (158), Expect = 3e-10
Identities = 163/890 (18%), Positives = 367/890 (41%), Gaps = 119/890 (13%)
Query: 313 IPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPL 372
IP K+ A+ + + +G L+ S V +LSD + DD +PL
Sbjct: 48 IPTKTDKKKAEKKKNKKKEIQNGNLHES----DSESVPRDFKLSDALAVEDDQVAP-VPL 102
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSV-SDSHLAELQ----EKIQQTEATNKILQEKLNE 427
V + + +++K + + ++ V +S +++ E + T+ + ++
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 428 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE-----GQNDTMAKLRE--- 479
K ++ S QD ++ L + S+ +E L+Q + G+ +K ++
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
Query: 480 ------MLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++H + L + +SP + ++DL ++ +++ + +++ A
Sbjct: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
Query: 534 DAK--------QCVQFVE-AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQ 580
+ K + + F E A + KE S L+K+ L L +LQ K +
Sbjct: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
Query: 581 LRAWEAEKY----------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN-SDKT 629
L A + + E+ T+++ + + + L++ + Q + + S +
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 630 LEANEMLLEKLRQRIHDKAVALER-------AIDEKFSALEEKEK-ELRQLRLAVRERDH 681
+ +M +++R+++ + L++ A+ + LE K+ EL +LR
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR-------Q 453
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 741
D RL + L+ +Q E + QL Q + EE+++ + E E+
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
Query: 742 IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 801
Q LQ+ + EV+ L S++ + L + Q ++R++Q L+ K+V
Sbjct: 514 AQQDLQSKFVAKENEVQSL-----------HSKLTDTLVSKQQLEQRLMQ-LMESEQKRV 561
Query: 802 LEHE---MEIQGLLQ-----SVSTREQESQAAAEKLVQALMERNSELQAL--RQYLGGRD 851
+ E M++Q +L+ ++ SQ AA+ L E ++ A +Q D
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 852 SLMSQAP-ISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
SL S+ +++++ E+ + ++ + + + A E + +S D
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 911 VAGLEK----ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRN 966
+ LE+ E+SN EE +++ + + + E+ LQ++++ Q + V E + +
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV-----EQMEKC 736
Query: 967 IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 1026
IQ K++ +K ++ +L++ I + +E+ +R + +S+ + Q++ + Q +
Sbjct: 737 IQEKDEKLKTVE-ELLETGLIQVATK-EEELNAIRTENSSLTKEVQDLKAKQNDQ--VSF 792
Query: 1027 EGLVDERSRL-----NEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLE 1081
LV+E ++ + E L + L+K + +++T+Q+ + L+
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKV------ANKEKTVQLSITSKV---QELQ 843
Query: 1082 EVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQ 1131
+L E++N ++ + D +T D EE + +H Q
Sbjct: 844 NLLKGKEEQMNTMKAVL----EEKEKDLANTGKWLQDLQEENESLKAHVQ 889
Score = 35.4 bits (80), Expect = 0.31
Identities = 39/190 (20%), Positives = 89/190 (46%), Gaps = 18/190 (9%)
Query: 404 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 463
L +LQ ++Q E K+ ++ ++ +++ + SS+++ +++ + +++ RE E L
Sbjct: 1127 LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1186
Query: 464 YQVIEG----QNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQ 519
+E ++ + ++RE+ ++QL + + T ++Q DL A Q
Sbjct: 1187 EMELEKAEMERSTYVTEVREL--KAQLNETLTKLRTEQNERQKVAGDLHKA--------Q 1236
Query: 520 KLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ 579
+ +++ K + A ++ + + +KE + L + + QLQ+ LQ +Q
Sbjct: 1237 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM---SVSLNQTVTQLQQLLQAVNQ 1293
Query: 580 QLRAWEAEKY 589
QL E E Y
Sbjct: 1294 QLTK-EKEHY 1302
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 107 bits (268), Expect = 5e-23
Identities = 148/725 (20%), Positives = 316/725 (43%), Gaps = 95/725 (13%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 412
++L + + W+++ + Y+ R E QQ L S ++ + L K+
Sbjct: 488 VQLQEAERRWEEV-QSYIRKRT---AEHEAAQQDLQSKFVA------KENEVQSLHSKLT 537
Query: 413 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND 472
T + + L+++L ++ + + +Q++ E ++ + + ++ + I Q
Sbjct: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
Query: 473 TMAKLREMLHQ------SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
L E LH+ Q+ Q +SE ++ L D+Q+ F + E+QKLQ
Sbjct: 598 ASV-LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 524 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 583
+ ++ AAAHE E+ +++ + + ++R +QLQ E+ NK ++ +
Sbjct: 657 LANEQA--------------AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 584 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 643
++ ++++ Q +Q L +K+ ++++ + +Q +D KT+E LLE +
Sbjct: 703 LN-DQNKALKSEVQKLQTLVSEQPNKD-VVEQMEKCIQEKDEKLKTVEE---LLETGLIQ 757
Query: 644 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
+ K L AI + S+L ++ ++L+ + +E L+ V+ + ++S+E L
Sbjct: 758 VATKEEEL-NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 704 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ------ESIIQQLQTSLHDRNKEV 757
L A+ L+V T Q+L+ + ++ + Q E+ S +Q+LQ L + +++
Sbjct: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
Query: 758 EDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 817
+ A L EE + L + LQD L + N+ + H E+ +
Sbjct: 877 NTMKAVL------------EEKEKDLANTGKWLQD-LQEENESLKAHVQEV----AQHNL 919
Query: 818 REQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE------VTPTGC 871
+E S + E+L L E+ +EL+ L L R+S +S Q + +
Sbjct: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
Query: 872 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 931
L +Q Q + P ++ + ++ + I +GL EL + K+ +E KK
Sbjct: 980 LKQQNYQQASSFPPHEELLKVISEREKEI-----------SGLWNELDSLKDAVEHQRKK 1028
Query: 932 E---RESQME-LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDI 987
RE E + AL S + ++++ + + + ++++ K++ +L +
Sbjct: 1029 NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE---AKEVLKKLFPKVSV 1085
Query: 988 PAMERLTQEVLLLREKVASVESQGQE-ISGNRRQQLLLMLEGLVDERSRLNEALQAERQL 1046
P+ L E + E + +E ++G + + +LE + E ++ LQ E +
Sbjct: 1086 PSN-------LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEK 1138
Query: 1047 YSSLV 1051
Y S++
Sbjct: 1139 YKSVL 1143
Score = 88.6 bits (218), Expect = 3e-17
Identities = 189/961 (19%), Positives = 382/961 (39%), Gaps = 188/961 (19%)
Query: 231 ESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLEL 290
ES + PG VE + + Q +PP + ++ ++ K SDDQ + K+E
Sbjct: 132 ESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG--SDDQ------DKKVET 183
Query: 291 ALSMIKGLDYKPIQSPRGSRLPI---PVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKT 347
+ + S R LP+ + S G K S + F++ +PL
Sbjct: 184 LM----------VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVD---EPLIHA 230
Query: 348 PVSYPL-------ELSDLQELWDDLCED-----------------------------YLP 371
PL + D +E+ D L D L
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 372 LRVQPMTE-ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKIL--------- 421
L+ +E E L L ++ + Q ++ S EL I Q + +K+L
Sbjct: 291 LKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA 350
Query: 422 -QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL-------YQVIEGQNDT 473
+++ +++ E+ +E S + I +K+ + + E+E YQ +
Sbjct: 351 TKDRCKQLTQEMMTEKERS---NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
Query: 474 MAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++RE + ++++ L G L+S E+ KL++ + +L
Sbjct: 408 FQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESK---QSAELNKLRQDYARLVNELT 463
Query: 534 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 593
+ +Q E +EQ QE + +++Q ++ ++ + A + + ++
Sbjct: 464 EKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV 523
Query: 594 TQEQNIQHLNHSLS----HKEQLLQEFRELL---QYRDNSDKT--------LEANEMLLE 638
+E +Q L+ L+ K+QL Q +L+ Q R N +++ LE NE L
Sbjct: 524 AKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 639 KLRQRIHDKAVALERA---IDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 695
++ Q+ H + A A +E + EK+K+++Q + L RD L+S E
Sbjct: 584 QI-QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-------TEDSLASERDRLTSKEE 635
Query: 696 TM---QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 752
+ Q+M LL+A+ Q LQ L E +K Q+S+
Sbjct: 636 ELKDIQNMNFLLKAE----------VQKLQALANEQAAAAHELEKMQQSVY--------- 676
Query: 753 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 812
V+D LL + ++ E+ +++ + +L+D+NK + ++Q L+
Sbjct: 677 ----VKDDKIRLL------EEQLQHEISNKMEEFK-----ILNDQNKALKSEVQKLQTLV 721
Query: 813 QSVSTREQESQAAAEKLVQALMERNSELQALRQYL-------GGRDSLMSQAPISNQQAE 865
EQ ++ E++ + + E++ +L+ + + L ++ ++ N
Sbjct: 722 S-----EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 866 VTPTGCLGKQTDQGSMQIPSRDDSTSLTAKED--VSIPRSTLGDLDTVAGLEKELSNAKE 923
KQ DQ S + + K+ S+ +L VA EK + + K+
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 924 ELELMAKK------ERESQMELSA----LQSMMAVQEEELQVQAADMESLTRNIQIKEDL 973
E++ + ++ E+ Q+ +++ LQ+++ +EE++ A +E +++
Sbjct: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
Query: 974 IKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ--EISGNRRQQLLLMLEGLVD 1031
++DLQ E+ +++ QEV K AS SQ + EI ++ L LE ++
Sbjct: 897 LQDLQ------EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 1032 ER-------SRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
ER ++L + +Q E +L+ S ++ ++ ++ + E +V+ R +E+
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEIS 1009
Query: 1085 G 1085
G
Sbjct: 1010 G 1010
Score = 87.0 bits (214), Expect = 9e-17
Identities = 159/809 (19%), Positives = 344/809 (42%), Gaps = 109/809 (13%)
Query: 367 EDYLPLRVQPMTE--ELLKQQKLNSHETTITQQSVS----DSH--LAELQEKIQQTEATN 418
E+ L ++VQ + E E LK Q H Q S S + H +AE ++I+QTE +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Query: 419 KILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE---RETEELYQVIEGQNDTMA 475
+++L ELK Q + +Q L+ + E E++ Q + ++D +
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 476 KLREMLHQSQLGQLHS----SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ 531
L E L ++ ++ + +V L + ++ ++++++ +++K+ +
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 532 LADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKS------QQLRAWE 585
L ++ ++ E++ A N L K +Q L+ + ++ ++L+
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803
Query: 586 AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH 645
EK +I++ E+ ++ +++KE+ +Q+ ++ ++ E + LEK +Q
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE-----EIGNVQLEKAQQ--- 855
Query: 646 DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER----LRDVLSSNEATMQSME 701
+++ + E + L+ KE+++ ++ + E++ DL L+D+ NE+ ++
Sbjct: 856 ---LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ 912
Query: 702 SLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQ---QLQTSLHDRNK 755
+ + L+ ++ + L+ + +E E + R + KE+ES + QL + D NK
Sbjct: 913 EVAQ-HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 971
Query: 756 EVEDLSATLLCKLGPGQSEIA--EELCQRLQRKERMLQDLLS--DRNKQVLEHEMEIQGL 811
+ L + S EEL + + +E+ + L + D K +EH+ +
Sbjct: 972 LFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND 1031
Query: 812 LQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC 871
L+ + E+ A+ EK++Q + + S+ RQ L ++ + +V+
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKE---RQQQVEAVELEAKEVLKKLFPKVSVPSN 1088
Query: 872 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL-----EKELSNAKEELE 926
L + +++ + E+V + L + D + L EK S E
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1148
Query: 927 LMAKKER--------------ESQMELSALQSMMAVQEEEL------------------- 953
++ K +R ES + +QS E+EL
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1208
Query: 954 ---QVQAADMESLTRNIQIKE--DLIKDLQMQLVD--PEDIPAMERLTQEVLLLRE---K 1003
+++ A+ME T +++E DL+ +LQ +L D E + E L L E K
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 1004 VASVESQGQEISG--NRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSE 1061
+ + +++ Q+++G ++ QQ L +++ S++ +A + +S V ESSE
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQ------SKIVKAAGDTTVIENSDVS--PETESSE 1320
Query: 1062 RDRTLQVELEGAQVLRSRLEEVLGRSLER 1090
++ T+ V L +L + + + L +
Sbjct: 1321 KE-TMSVSLNQTVTQLQQLLQAVNQQLTK 1348
Score = 72.4 bits (176), Expect = 2e-12
Identities = 122/593 (20%), Positives = 257/593 (43%), Gaps = 76/593 (12%)
Query: 381 LLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQ 440
L+++ K HE +SV + AEL K+ E T + L++++ + E+ Q
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELL-KVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853
Query: 441 KQ---DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSP 497
+Q +Q L+ LK +E + + V+E + +A + L Q +E
Sbjct: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ----EENESLKA 909
Query: 498 AQQQVALLDLQSALFCSQLE------------IQKLQRVVRQKERQLADAKQCVQFVE-- 543
Q+VA +L+ A SQ E +++L+ +++++E L+ Q +Q V+
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 544 --------AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW------EAEKY 589
+ Q+ +S+ ++EL K + + ++E+ +L + + +K
Sbjct: 970 NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
Query: 590 NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDK-A 648
N++R E+N + + +L+ E++LQ+ ++ + + +EA E+ +++ +++ K +
Sbjct: 1030 NDLR--EKNWEAME-ALASTEKMLQD--KVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
V + E E+K KE +A +++ L L + M +LL+
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKEC----MAGTSGSEEVKVLEHKLKEAD----EMHTLLQ--- 1133
Query: 709 LEVEQ----LSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTSLHDRNKEVEDLS 761
LE E+ L+ T LQ L+ +E + ++W+ E I+Q+Q+S +E+E L
Sbjct: 1134 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193
Query: 762 ATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQE 821
+ +++ E L + + E L+ +R+ V E E++ LL + + +
Sbjct: 1194 S---------ENKDIENLRREREHLEMELEKAEMERSTYVTE-VRELKDLLTELQKKLDD 1243
Query: 822 SQAAA----EKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTD 877
S + A E+L + N L LR R + + Q E+ + + D
Sbjct: 1244 SYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1303
Query: 878 QGSMQIPSRDDSTSLTAKEDVSIP-RSTLGDL-DTVAGLEKELSNAKEELELM 928
++ T + KE +S+ T+ L + + ++L+ KE +++
Sbjct: 1304 TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1356
Score = 66.2 bits (160), Expect = 2e-10
Identities = 170/902 (18%), Positives = 374/902 (41%), Gaps = 120/902 (13%)
Query: 313 IPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPL 372
IP K+ A+ + + +G L+ S V +LSD + DD +PL
Sbjct: 48 IPTKTDKKKAEKKKNKKKEIQNGNLHES----DSESVPRDFKLSDALAVEDDQVAP-VPL 102
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSV-SDSHLAELQ----EKIQQTEATNKILQEKLNE 427
V + + +++K + + ++ V +S +++ E + T+ + ++
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 428 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE-----GQNDTMAKLRE--- 479
K ++ S QD ++ L + S+ +E L+Q + G+ +K ++
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
Query: 480 ------MLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++H + L + +SP + ++DL ++ +++ + +++ A
Sbjct: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
Query: 534 DAK--------QCVQFVE-AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQ 580
+ K + + F E A + KE S L+K+ L L +LQ K +
Sbjct: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
Query: 581 LRAWEAEKY----------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN-SDKT 629
L A + + E+ T+++ + + + L++ + Q + + S +
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 630 LEANEMLLEKLRQRIHDKAVALER-------AIDEKFSALEEKEK-ELRQLRLAVRERDH 681
+ +M +++R+++ + L++ A+ + LE K+ EL +LR
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR-------Q 453
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 741
D RL + L+ +Q E + QL Q + EE+++ + E E+
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
Query: 742 IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 801
Q LQ+ + EV+ L S++ + L + Q ++R++Q L+ K+V
Sbjct: 514 AQQDLQSKFVAKENEVQSL-----------HSKLTDTLVSKQQLEQRLMQ-LMESEQKRV 561
Query: 802 LEHE---MEIQGLLQ-----SVSTREQESQAAAEKLVQALMERNSELQAL--RQYLGGRD 851
+ E M++Q +L+ ++ SQ AA+ L E ++ A +Q D
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 852 SLMSQAP-ISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
SL S+ +++++ E+ + ++ + + + A E + +S D
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 911 VAGLEK----ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRN 966
+ LE+ E+SN EE +++ + + + E+ LQ++++ Q + V E + +
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV-----EQMEKC 736
Query: 967 IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 1026
IQ K++ +K ++ +L++ I + +E+ +R + +S+ + Q++ + Q +
Sbjct: 737 IQEKDEKLKTVE-ELLETGLIQVATK-EEELNAIRTENSSLTKEVQDLKAKQNDQ--VSF 792
Query: 1027 EGLVDERSRL-----NEALQAERQLYSSLVKFHAHPESSERDRTLQ----------VELE 1071
LV+E ++ + E L + L+K A+ E + +D + V+LE
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKV-ANKEKTVQDLKQEIKALKEEIGNVQLE 851
Query: 1072 GAQVL--RSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSH 1129
AQ L S+++E+ + ++ T+ A+ D +T D EE + +H
Sbjct: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAV-LEEKEKDLANTGKWLQDLQEENESLKAH 910
Query: 1130 QQ 1131
Q
Sbjct: 911 VQ 912
Score = 37.0 bits (84), Expect = 0.11
Identities = 43/211 (20%), Positives = 88/211 (41%), Gaps = 17/211 (8%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES 438
EE + K++ TI Q S + + E+++ + L+ + + EL+ A+
Sbjct: 1160 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1219
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA 498
++ LK+ L +++ ++ Y QN+ + L+ +QL + + T
Sbjct: 1220 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLK-----AQLNETLTKLRTEQN 1274
Query: 499 QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK 558
++Q DL A Q+ +++ K + A ++ + + +KE
Sbjct: 1275 ERQKVAGDLHKA--------QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM-- 1324
Query: 559 HNQELRKALQQLQEELQNKSQQLRAWEAEKY 589
+ L + + QLQ+ LQ +QQL E E Y
Sbjct: 1325 -SVSLNQTVTQLQQLLQAVNQQLTK-EKEHY 1353
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 107 bits (268), Expect = 5e-23
Identities = 148/725 (20%), Positives = 316/725 (43%), Gaps = 95/725 (13%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 412
++L + + W+++ + Y+ R E QQ L S ++ + L K+
Sbjct: 488 VQLQEAERRWEEV-QSYIRKRT---AEHEAAQQDLQSKFVA------KENEVQSLHSKLT 537
Query: 413 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND 472
T + + L+++L ++ + + +Q++ E ++ + + ++ + I Q
Sbjct: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
Query: 473 TMAKLREMLHQ------SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
L E LH+ Q+ Q +SE ++ L D+Q+ F + E+QKLQ
Sbjct: 598 ASV-LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 524 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 583
+ ++ AAAHE E+ +++ + + ++R +QLQ E+ NK ++ +
Sbjct: 657 LANEQA--------------AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 584 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 643
++ ++++ Q +Q L +K+ ++++ + +Q +D KT+E LLE +
Sbjct: 703 LN-DQNKALKSEVQKLQTLVSEQPNKD-VVEQMEKCIQEKDEKLKTVEE---LLETGLIQ 757
Query: 644 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
+ K L AI + S+L ++ ++L+ + +E L+ V+ + ++S+E L
Sbjct: 758 VATKEEEL-NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Query: 704 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ------ESIIQQLQTSLHDRNKEV 757
L A+ L+V T Q+L+ + ++ + Q E+ S +Q+LQ L + +++
Sbjct: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
Query: 758 EDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 817
+ A L EE + L + LQD L + N+ + H E+ +
Sbjct: 877 NTMKAVL------------EEKEKDLANTGKWLQD-LQEENESLKAHVQEV----AQHNL 919
Query: 818 REQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE------VTPTGC 871
+E S + E+L L E+ +EL+ L L R+S +S Q + +
Sbjct: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
Query: 872 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 931
L +Q Q + P ++ + ++ + I +GL EL + K+ +E KK
Sbjct: 980 LKQQNYQQASSFPPHEELLKVISEREKEI-----------SGLWNELDSLKDAVEHQRKK 1028
Query: 932 E---RESQME-LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDI 987
RE E + AL S + ++++ + + + ++++ K++ +L +
Sbjct: 1029 NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE---AKEVLKKLFPKVSV 1085
Query: 988 PAMERLTQEVLLLREKVASVESQGQE-ISGNRRQQLLLMLEGLVDERSRLNEALQAERQL 1046
P+ L E + E + +E ++G + + +LE + E ++ LQ E +
Sbjct: 1086 PSN-------LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEK 1138
Query: 1047 YSSLV 1051
Y S++
Sbjct: 1139 YKSVL 1143
Score = 88.6 bits (218), Expect = 3e-17
Identities = 189/961 (19%), Positives = 382/961 (39%), Gaps = 188/961 (19%)
Query: 231 ESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLEL 290
ES + PG VE + + Q +PP + ++ ++ K SDDQ + K+E
Sbjct: 132 ESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG--SDDQ------DKKVET 183
Query: 291 ALSMIKGLDYKPIQSPRGSRLPI---PVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKT 347
+ + S R LP+ + S G K S + F++ +PL
Sbjct: 184 LM----------VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVD---EPLIHA 230
Query: 348 PVSYPL-------ELSDLQELWDDLCED-----------------------------YLP 371
PL + D +E+ D L D L
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 372 LRVQPMTE-ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKIL--------- 421
L+ +E E L L ++ + Q ++ S EL I Q + +K+L
Sbjct: 291 LKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA 350
Query: 422 -QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL-------YQVIEGQNDT 473
+++ +++ E+ +E S + I +K+ + + E+E YQ +
Sbjct: 351 TKDRCKQLTQEMMTEKERS---NVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
Query: 474 MAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++RE + ++++ L G L+S E+ KL++ + +L
Sbjct: 408 FQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESK---QSAELNKLRQDYARLVNELT 463
Query: 534 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIR 593
+ +Q E +EQ QE + +++Q ++ ++ + A + + ++
Sbjct: 464 EKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV 523
Query: 594 TQEQNIQHLNHSLS----HKEQLLQEFRELL---QYRDNSDKT--------LEANEMLLE 638
+E +Q L+ L+ K+QL Q +L+ Q R N +++ LE NE L
Sbjct: 524 AKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 639 KLRQRIHDKAVALERA---IDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 695
++ Q+ H + A A +E + EK+K+++Q + L RD L+S E
Sbjct: 584 QI-QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ-------TEDSLASERDRLTSKEE 635
Query: 696 TM---QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 752
+ Q+M LL+A+ Q LQ L E +K Q+S+
Sbjct: 636 ELKDIQNMNFLLKAE----------VQKLQALANEQAAAAHELEKMQQSVY--------- 676
Query: 753 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 812
V+D LL + ++ E+ +++ + +L+D+NK + ++Q L+
Sbjct: 677 ----VKDDKIRLL------EEQLQHEISNKMEEFK-----ILNDQNKALKSEVQKLQTLV 721
Query: 813 QSVSTREQESQAAAEKLVQALMERNSELQALRQYL-------GGRDSLMSQAPISNQQAE 865
EQ ++ E++ + + E++ +L+ + + L ++ ++ N
Sbjct: 722 S-----EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 866 VTPTGCLGKQTDQGSMQIPSRDDSTSLTAKED--VSIPRSTLGDLDTVAGLEKELSNAKE 923
KQ DQ S + + K+ S+ +L VA EK + + K+
Sbjct: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
Query: 924 ELELMAKK------ERESQMELSA----LQSMMAVQEEELQVQAADMESLTRNIQIKEDL 973
E++ + ++ E+ Q+ +++ LQ+++ +EE++ A +E +++
Sbjct: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
Query: 974 IKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQ--EISGNRRQQLLLMLEGLVD 1031
++DLQ E+ +++ QEV K AS SQ + EI ++ L LE ++
Sbjct: 897 LQDLQ------EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 1032 ER-------SRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
ER ++L + +Q E +L+ S ++ ++ ++ + E +V+ R +E+
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEIS 1009
Query: 1085 G 1085
G
Sbjct: 1010 G 1010
Score = 87.0 bits (214), Expect = 9e-17
Identities = 159/809 (19%), Positives = 344/809 (42%), Gaps = 109/809 (13%)
Query: 367 EDYLPLRVQPMTE--ELLKQQKLNSHETTITQQSVS----DSH--LAELQEKIQQTEATN 418
E+ L ++VQ + E E LK Q H Q S S + H +AE ++I+QTE +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Query: 419 KILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE---RETEELYQVIEGQNDTMA 475
+++L ELK Q + +Q L+ + E E++ Q + ++D +
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 476 KLREMLHQSQLGQLHS----SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ 531
L E L ++ ++ + +V L + ++ ++++++ +++K+ +
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 532 LADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKS------QQLRAWE 585
L ++ ++ E++ A N L K +Q L+ + ++ ++L+
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803
Query: 586 AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIH 645
EK +I++ E+ ++ +++KE+ +Q+ ++ ++ E + LEK +Q
Sbjct: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE-----EIGNVQLEKAQQ--- 855
Query: 646 DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER----LRDVLSSNEATMQSME 701
+++ + E + L+ KE+++ ++ + E++ DL L+D+ NE+ ++
Sbjct: 856 ---LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ 912
Query: 702 SLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQ---QLQTSLHDRNK 755
+ + L+ ++ + L+ + +E E + R + KE+ES + QL + D NK
Sbjct: 913 EVAQ-HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 971
Query: 756 EVEDLSATLLCKLGPGQSEIA--EELCQRLQRKERMLQDLLS--DRNKQVLEHEMEIQGL 811
+ L + S EEL + + +E+ + L + D K +EH+ +
Sbjct: 972 LFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND 1031
Query: 812 LQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC 871
L+ + E+ A+ EK++Q + + S+ RQ L ++ + +V+
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKE---RQQQVEAVELEAKEVLKKLFPKVSVPSN 1088
Query: 872 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL-----EKELSNAKEELE 926
L + +++ + E+V + L + D + L EK S E
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1148
Query: 927 LMAKKER--------------ESQMELSALQSMMAVQEEEL------------------- 953
++ K +R ES + +QS E+EL
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1208
Query: 954 ---QVQAADMESLTRNIQIKE--DLIKDLQMQLVD--PEDIPAMERLTQEVLLLRE---K 1003
+++ A+ME T +++E DL+ +LQ +L D E + E L L E K
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 1004 VASVESQGQEISG--NRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSE 1061
+ + +++ Q+++G ++ QQ L +++ S++ +A + +S V ESSE
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQ------SKIVKAAGDTTVIENSDVS--PETESSE 1320
Query: 1062 RDRTLQVELEGAQVLRSRLEEVLGRSLER 1090
++ T+ V L +L + + + L +
Sbjct: 1321 KE-TMSVSLNQTVTQLQQLLQAVNQQLTK 1348
Score = 72.4 bits (176), Expect = 2e-12
Identities = 122/593 (20%), Positives = 257/593 (43%), Gaps = 76/593 (12%)
Query: 381 LLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQ 440
L+++ K HE +SV + AEL K+ E T + L++++ + E+ Q
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELL-KVANKEKTVQDLKQEIKALKEEIGNVQLEKA 853
Query: 441 KQ---DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSP 497
+Q +Q L+ LK +E + + V+E + +A + L Q +E
Sbjct: 854 QQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ----EENESLKA 909
Query: 498 AQQQVALLDLQSALFCSQLE------------IQKLQRVVRQKERQLADAKQCVQFVE-- 543
Q+VA +L+ A SQ E +++L+ +++++E L+ Q +Q V+
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 544 --------AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW------EAEKY 589
+ Q+ +S+ ++EL K + + ++E+ +L + + +K
Sbjct: 970 NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
Query: 590 NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDK-A 648
N++R E+N + + +L+ E++LQ+ ++ + + +EA E+ +++ +++ K +
Sbjct: 1030 NDLR--EKNWEAME-ALASTEKMLQD--KVNKTSKERQQQVEAVELEAKEVLKKLFPKVS 1084
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
V + E E+K KE +A +++ L L + M +LL+
Sbjct: 1085 VPSNLSYGEWLHGFEKKAKEC----MAGTSGSEEVKVLEHKLKEAD----EMHTLLQ--- 1133
Query: 709 LEVEQ----LSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTSLHDRNKEVEDLS 761
LE E+ L+ T LQ L+ +E + ++W+ E I+Q+Q+S +E+E L
Sbjct: 1134 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193
Query: 762 ATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQE 821
+ +++ E L + + E L+ +R+ V E E++ LL + + +
Sbjct: 1194 S---------ENKDIENLRREREHLEMELEKAEMERSTYVTE-VRELKDLLTELQKKLDD 1243
Query: 822 SQAAA----EKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTD 877
S + A E+L + N L LR R + + Q E+ + + D
Sbjct: 1244 SYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1303
Query: 878 QGSMQIPSRDDSTSLTAKEDVSIP-RSTLGDL-DTVAGLEKELSNAKEELELM 928
++ T + KE +S+ T+ L + + ++L+ KE +++
Sbjct: 1304 TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1356
Score = 66.2 bits (160), Expect = 2e-10
Identities = 170/902 (18%), Positives = 374/902 (41%), Gaps = 120/902 (13%)
Query: 313 IPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPL 372
IP K+ A+ + + +G L+ S V +LSD + DD +PL
Sbjct: 48 IPTKTDKKKAEKKKNKKKEIQNGNLHES----DSESVPRDFKLSDALAVEDDQVAP-VPL 102
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSV-SDSHLAELQ----EKIQQTEATNKILQEKLNE 427
V + + +++K + + ++ V +S +++ E + T+ + ++
Sbjct: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
Query: 428 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE-----GQNDTMAKLRE--- 479
K ++ S QD ++ L + S+ +E L+Q + G+ +K ++
Sbjct: 163 KKPGQKKSKNGSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
Query: 480 ------MLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLA 533
++H + L + +SP + ++DL ++ +++ + +++ A
Sbjct: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
Query: 534 DAK--------QCVQFVE-AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQ 580
+ K + + F E A + KE S L+K+ L L +LQ K +
Sbjct: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
Query: 581 LRAWEAEKY----------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN-SDKT 629
L A + + E+ T+++ + + + L++ + Q + + S +
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 630 LEANEMLLEKLRQRIHDKAVALER-------AIDEKFSALEEKEK-ELRQLRLAVRERDH 681
+ +M +++R+++ + L++ A+ + LE K+ EL +LR
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR-------Q 453
Query: 682 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 741
D RL + L+ +Q E + QL Q + EE+++ + E E+
Sbjct: 454 DYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
Query: 742 IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 801
Q LQ+ + EV+ L S++ + L + Q ++R++Q L+ K+V
Sbjct: 514 AQQDLQSKFVAKENEVQSL-----------HSKLTDTLVSKQQLEQRLMQ-LMESEQKRV 561
Query: 802 LEHE---MEIQGLLQ-----SVSTREQESQAAAEKLVQALMERNSELQAL--RQYLGGRD 851
+ E M++Q +L+ ++ SQ AA+ L E ++ A +Q D
Sbjct: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED 621
Query: 852 SLMSQAP-ISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
SL S+ +++++ E+ + ++ + + + A E + +S D
Sbjct: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
Query: 911 VAGLEK----ELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRN 966
+ LE+ E+SN EE +++ + + + E+ LQ++++ Q + V E + +
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV-----EQMEKC 736
Query: 967 IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 1026
IQ K++ +K ++ +L++ I + +E+ +R + +S+ + Q++ + Q +
Sbjct: 737 IQEKDEKLKTVE-ELLETGLIQVATK-EEELNAIRTENSSLTKEVQDLKAKQNDQ--VSF 792
Query: 1027 EGLVDERSRL-----NEALQAERQLYSSLVKFHAHPESSERDRTLQ----------VELE 1071
LV+E ++ + E L + L+K A+ E + +D + V+LE
Sbjct: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKV-ANKEKTVQDLKQEIKALKEEIGNVQLE 851
Query: 1072 GAQVL--RSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSH 1129
AQ L S+++E+ + ++ T+ A+ D +T D EE + +H
Sbjct: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAV-LEEKEKDLANTGKWLQDLQEENESLKAH 910
Query: 1130 QQ 1131
Q
Sbjct: 911 VQ 912
Score = 37.0 bits (84), Expect = 0.11
Identities = 43/211 (20%), Positives = 88/211 (41%), Gaps = 17/211 (8%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES 438
EE + K++ TI Q S + + E+++ + L+ + + EL+ A+
Sbjct: 1160 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1219
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA 498
++ LK+ L +++ ++ Y QN+ + L+ +QL + + T
Sbjct: 1220 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLK-----AQLNETLTKLRTEQN 1274
Query: 499 QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK 558
++Q DL A Q+ +++ K + A ++ + + +KE
Sbjct: 1275 ERQKVAGDLHKA--------QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM-- 1324
Query: 559 HNQELRKALQQLQEELQNKSQQLRAWEAEKY 589
+ L + + QLQ+ LQ +QQL E E Y
Sbjct: 1325 -SVSLNQTVTQLQQLLQAVNQQLTK-EKEHY 1353
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 105 bits (262), Expect = 2e-22
Identities = 174/860 (20%), Positives = 354/860 (41%), Gaps = 112/860 (13%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 412
L+L + + +LC + LR + ++ ++ + E + ++ HL ++K+Q
Sbjct: 883 LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 413 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQND 472
Q + E+ +L+ + + QK +Q K T +++ ++ EE ++E QN
Sbjct: 943 Q----------NIQELEEQLEEEESARQK----LQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 473 TMAKLREMLHQ---------SQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 523
+AK +++L ++ + S + + + DL+ L + + Q+L++
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 524 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 583
R+ E D + ++A E + Q K +EL+ AL +++EE K+ L+
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLA---KKEEELQAALARVEEEAAQKNMALK- 1104
Query: 584 WEAEKYNEIRTQEQNIQH--------LNHSLSHKEQLLQEFREL-LQYRDNSDKTLEANE 634
K E+ +Q +Q N + K L +E L + D D T E
Sbjct: 1105 ----KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 635 MLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLR-LAVRERDHDLERLRDVLSSN 693
LR + + L++ ++E+ E + +E+RQ AV E LE+ + V ++
Sbjct: 1161 -----LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 694 EATMQSMES-----------LLRAKG----------LEVEQLSTTCQNLQWLKEEMETKF 732
E Q++E+ LL+ KG ++++L + ++ E+ K
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 733 SRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR--LQRKERML 790
++ Q E +++ L S +K +D SA L +L Q + EE Q+ L K + +
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSA-LESQLQDTQELLQEENRQKLSLSTKLKQV 1334
Query: 791 QDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL--MERNSEL-QALRQYL 847
+D + +Q+ E E L + ++T + +K+ ++ +E E+ + L++ L
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTD---------QGSMQIPSRDDSTSLTAKEDV 898
G + + + E T T + D Q + + + E+
Sbjct: 1395 EGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454
Query: 899 SIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA 958
+I + D +E L ++ E + EL L + E+L
Sbjct: 1455 TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD 1514
Query: 959 D----MESLTRNIQIKEDLIKDLQMQLVDPED-IPAME--RLTQEVLLLREK------VA 1005
D + L ++ + E +++++ QL + ED + A E +L EV L K +
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
Query: 1006 SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD-- 1063
+ Q +E +Q+ M L DER + + A+ A ++L L AH +S+ ++
Sbjct: 1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634
Query: 1064 ------RTLQVELEGA----QVLRSRLEEVLGRSLERLNRLETLAA-----IGGAAAGDD 1108
R LQ +++ R+ EE+L ++ E +L+++ A AA +
Sbjct: 1635 EAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Query: 1109 TEDTSTEFTDSIEEEAAHHS 1128
+ + + D + +E A+ S
Sbjct: 1695 AKRQAQQERDELADEIANSS 1714
Score = 89.0 bits (219), Expect = 2e-17
Identities = 129/636 (20%), Positives = 262/636 (41%), Gaps = 68/636 (10%)
Query: 459 ETEELYQVIEGQNDTMAKLREML--HQSQLGQLHSSEGTSPAQQQVALLD-LQSALFCSQ 515
+ + L QV + + MAK E++ + QL A+ ++ ++ LQS L +
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLA----------AENRLTEMETLQSQLMAEK 882
Query: 516 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 575
L++Q E+ A+ + C E+E+ + QEL + L+ ++
Sbjct: 883 LQLQ---------EQLQAETELCA--------EAEELRARLTAKKQELEEICHDLEARVE 925
Query: 576 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 635
+ ++ + +AEK + +QNIQ L L +E Q+ + + K LE ++
Sbjct: 926 EEEERCQHLQAEK----KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 636 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 695
+LE ++ + LE I E + L E+E++ + L + + + L + L E
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 696 TMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNK 755
Q +E R + LS LQ E++ + ++ ++E ++ + +++ +N
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNM 1101
Query: 756 EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRN--KQVLEHEMEIQGLLQ 813
++ + L ++ Q ++ E R + E+ +DL + K LE ++ Q
Sbjct: 1102 ALKKI-RELESQISELQEDLESERASR-NKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 814 SV-STREQESQAAAEKLVQALMERNSELQALRQ-------YLGGRDSLMSQAPISNQQAE 865
+ S REQE + L + +++Q +RQ L + + + ++A+
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 866 VTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSI----------PRSTLGDLDTVAGLE 915
T G+ ++ + + + DS K + + R D V L+
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 916 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 975
EL N L K + + SAL+S + +E LQ + SL+ ++ ED
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 976 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 1035
+ QL + E+ A L +++ L +VA ++ + ++ G LE + + +
Sbjct: 1340 SFREQLEEEEE--AKHNLEKQIATLHAQVADMKKKMEDSVG--------CLETAEEVKRK 1389
Query: 1036 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELE 1071
L + L+ Q + K A+ + + LQ EL+
Sbjct: 1390 LQKDLEGLSQRHEE--KVAAYDKLEKTKTRLQQELD 1423
Score = 88.6 bits (218), Expect = 3e-17
Identities = 152/800 (19%), Positives = 324/800 (40%), Gaps = 103/800 (12%)
Query: 384 QQKLNSHETTITQQSVSDSH-LAELQEKIQQT-------EATNKILQEKLNEMSYELKC- 434
+++ +HE I + S + EL E+++QT E + L+ + E++ E+K
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 435 ------AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQ 488
++ +K + +Q L+ ER EL + + + +L QS
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 489 LHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHE 548
++ S + Q L D Q L + L ++Q E + ++ ++ E A H
Sbjct: 1297 SKLTKDFSALESQ--LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354
Query: 549 SEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH 608
E+Q +++K ++ L+ + R + + + E+ + +
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 609 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKF------SAL 662
K +L QE +LL D+ + LEK +Q+ D+ +A E+ I K+ +
Sbjct: 1415 KTRLQQELDDLLVDLDHQ----RQSACNLEK-KQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 663 EEKEKELRQLRLA-----VRERDHDLERL--------RDVLSSNE---ATMQSMESLLRA 706
E +EKE + L LA E+ +LERL D++SS + ++ +E RA
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA 1529
Query: 707 KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC 766
+VE++ T + L+ + E R + +++ Q + L R+++ E+ L+
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 767 KLGPGQSEIAEELCQR------LQRKERMLQDL---LSDRNK---QVLEHEMEIQGLLQS 814
++ ++E+ +E QR ++ E L+DL + NK + ++ ++Q ++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 815 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 874
+++A+ E+++ E +L+++ + ++ A + +QA+ +
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ--------Q 1701
Query: 875 QTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERE 934
+ D+ + +I + +L +E + +A LE+EL + EL+ + ++
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEA-------RIAQLEEELEEEQGNTELINDRLKK 1754
Query: 935 SQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLT 994
+ +++ + + + ++ Q + L R K+L+++L + E +
Sbjct: 1755 ANLQIDQINTDLNLERSHAQKNENARQQLERQ-------NKELKVKLQEMEG-TVKSKYK 1806
Query: 995 QEVLLLREKVASVESQGQEISGNRR----------QQLLLMLEGLVDERSRLNEALQAER 1044
+ L K+A +E Q + R+ ++L +L + DER +
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 1045 QLYSSLVKFHAHPESSERD--------RTLQVELEGAQVLRSRLEEVLGRSLERLNR--- 1093
+ + L + E +E + R LQ ELE A + + +L R
Sbjct: 1867 KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
Query: 1094 ---LETLAAIGGAAAGDDTE 1110
+ A GA G D E
Sbjct: 1927 PFVVPRRMARKGAGDGSDEE 1946
Score = 80.1 bits (196), Expect = 1e-14
Identities = 114/629 (18%), Positives = 260/629 (41%), Gaps = 64/629 (10%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS 439
E L++++ H Q + + +A++++K++ + + +E ++ +L+ +
Sbjct: 1343 EQLEEEEEAKHNLE-KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 440 QKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA- 498
+++ L++T ++E ++L ++ Q + L + Q + QL + E T A
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK--QKKFDQLLAEEKTISAK 1459
Query: 499 -------------QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 545
+++ L L AL + + +L+R+ +Q ++ D V +
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 546 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQN 598
HE E+ K A + +E++ L++L++ELQ L+A +A+ +++ +++
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE- 1578
Query: 599 IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 658
S K+QL+++ RE+ ++ K +KL + D LE ID
Sbjct: 1579 -----QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD----LEAHIDSA 1629
Query: 659 FSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 718
+E K+LR+L+ +++ +L+ R S E Q+ E+ + K +E E +
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTR--ASREEILAQAKENEKKLKSMEAEMIQ--- 1684
Query: 719 QNLQWLKEEM---ETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI 775
L+EE+ E + Q+E++ + ++ S +E+ L ++ + E+
Sbjct: 1685 -----LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE-KRRLEARIAQLEEEL 1738
Query: 776 AEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 835
EE Q ++ D L N Q+ + ++ E+ E Q L
Sbjct: 1739 EEE-----QGNTELINDRLKKANLQIDQINTDL--------NLERSHAQKNENARQQLER 1785
Query: 836 RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 895
+N EL+ Q + G +A I+ +A++ L +Q D + + + T K
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQ---LEEQLDNETKERQAACKQVRRTEK 1842
Query: 896 EDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQV 955
+ + + + + A L+ + ++ E++ E + + EL+
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Query: 956 QAADMESLTRNIQIKEDLIKDLQMQLVDP 984
+++ R + ++ ++ + V P
Sbjct: 1903 ATETADAMNREVSSLKNKLRRGDLPFVVP 1931
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 105 bits (261), Expect = 3e-22
Identities = 181/807 (22%), Positives = 315/807 (39%), Gaps = 159/807 (19%)
Query: 395 TQQS--VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE- 451
TQQ+ V + +L+E++ TEA + +L ++ +L QE K +G +L+
Sbjct: 1255 TQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314
Query: 452 ---------TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQV 502
+L+SR R E +G+ + + +E L +Q+ L ++ + AQ
Sbjct: 1315 LMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL-TAQVEHLQAAVVEARAQASA 1373
Query: 503 ALL---DLQSALFCSQL-------EIQKLQRVVRQKERQLADAK---QCVQFVEAAAHES 549
A + DL++A +L E ++ Q + Q E ++A K + + + E
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433
Query: 550 EQQKEASWKHNQELRK-------ALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHL 602
E++ E QEL K AL+ L +L+ ++Q++ + E+ E+ ++HL
Sbjct: 1434 EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL-QQEQIQELEKCRSVLEHL 1492
Query: 603 NHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRI-------------- 644
++ +EQ L ++ REL + R+ LE + LEK Q I
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 645 -------------HDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD----------H 681
H K ++ I E E + L L L + ER H
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH 1612
Query: 682 DLERLRDVLSSN--------EATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEE---MET 730
DLE VL+ ++ + +E L R K + L Q L KE +E
Sbjct: 1613 DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672
Query: 731 KFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERML 790
+ +R K E ++Q++ SL +R +E+ T +L ++E + + + +
Sbjct: 1673 QRTRQTKILEEDLEQIKLSLRERGREL-----TTQRQLMQERAEEGKGPSKAQRGSLEHM 1727
Query: 791 QDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQA---LMERNSELQALRQYL 847
+ +L D+ K+V + I L + EQ+ Q K+ + L +R E+ L+Q L
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787
Query: 848 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 907
Q + Q L Q D+ + RD +E + G
Sbjct: 1788 ---QEAREQGELKEQS--------LQSQLDEAQRALAQRDQELEALQQEQ----QQAQGQ 1832
Query: 908 LDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNI 967
+ V L A E+ M KER +++ Q+ EEEL V+ R +
Sbjct: 1833 EERVKEKADALQGALEQAH-MTLKERHGELQDHKEQARRL--EEELAVEG-------RRV 1882
Query: 968 QIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLE 1027
Q E+++ DL+ A R ++ LL ++ + ++Q E+ Q L +
Sbjct: 1883 QALEEVLGDLR----------AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ 1932
Query: 1028 GLVDERSRLNEALQAERQ---------------LYSSLVKFHAHPESSER---------- 1062
++ ER + EAL+AE Q L +L K HA + E+
Sbjct: 1933 AVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSR 1992
Query: 1063 -----DRTLQVELEGAQVLRSRLEEVL 1084
TLQ L+ Q +LEE L
Sbjct: 1993 SLEASTATLQASLDACQAHSRQLEEAL 2019
Score = 101 bits (251), Expect = 5e-21
Identities = 175/728 (24%), Positives = 314/728 (43%), Gaps = 82/728 (11%)
Query: 380 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQ-EKLNEMSYELKCAQES 438
E+L+Q+ + Q DS A+ Q++ QQ E + + E+L EM L+ Q
Sbjct: 480 EVLEQEAWRLRRVNVELQLQGDS--AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE 537
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA 498
S + + L+E L+S E E L Q Q + A L + + +L SSE T
Sbjct: 538 SLSE---LITLREALESSHLEGELLRQE---QTEVTAALARA--EQSIAELSSSENTLKT 589
Query: 499 Q------QQVALLDLQSALFCSQLEIQKLQRVVRQKERQ-----LADAKQCVQFVEAAAH 547
+ V L L AL ++ + + Q + ++E Q + A+Q ++
Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQ-QLLQLEEENQSVCSRMEAAEQARNALQVDLA 648
Query: 548 ESEQQKEASWKHNQELRKALQQLQE---ELQNKSQQLRAWEAE---KYNEIRTQEQ---- 597
E+E+++EA W+ N L LQ+ +E ELQ + ++ + E K +E R Q++
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
Query: 598 NIQHLNHSLSHKEQLL----QEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALER 653
++ L+ +E++L QE L++ + + L+A E + L +++ + A E
Sbjct: 709 QLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768
Query: 654 AIDEKFSALEE-------------------KEKELRQLRLAVRERDHDLERLRDVLSSNE 694
F A ++ + KE+ Q + + + D ER + +
Sbjct: 769 LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA 828
Query: 695 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQ---TSLH 751
A Q ++ K +Q + + + L+E+ E + S Q+E ++ L+ L
Sbjct: 829 AARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 752 DRNKEVEDLSATLLCKLGPGQSEIAEELCQRL--QRKERM-LQDLLSDRNKQVLEHEMEI 808
R KE + + + +++ LCQ KER+ L + L K++ + ++
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948
Query: 809 QGLLQSVSTREQESQAAAEKLVQALMERNSEL-QALRQYLGGRDSLMSQAPISNQQAEVT 867
+ L Q + ++ + Q L L E EL +A RQ+ RD L + S+ +
Sbjct: 949 ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH---RDDLAALQEESSSLLQDK 1005
Query: 868 PTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKE-----LSNAK 922
L KQ + Q+ ++DDS L +E R T LE+E LS +
Sbjct: 1006 MD--LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 923 EELELMAKKERES--QMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQ 980
+E L+ +E +S Q ELSAL+ M + E + +A ME L + ++ KE + Q
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 981 LVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEAL 1040
L+ E++ A Q+ LR + + E++ ++ R + LE L E+ N+A
Sbjct: 1124 LL--EELEASHITEQQ---LRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQA- 1176
Query: 1041 QAERQLYS 1048
QA+ QL S
Sbjct: 1177 QAQAQLAS 1184
Score = 94.0 bits (232), Expect = 7e-19
Identities = 172/740 (23%), Positives = 318/740 (42%), Gaps = 107/740 (14%)
Query: 395 TQQSVSDSHLAELQEKIQ---QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451
TQ+ ++H QE IQ Q + LQ+++ E+S L +Q+ ++ + I+ L+E
Sbjct: 253 TQELEKEAH-ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311
Query: 452 TLKSRERETEEL--YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ--QQVALLDL 507
T++ E EL ++ +N KL + Q+ EG + AQ L+L
Sbjct: 312 TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL 371
Query: 508 QSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKAL 567
S++F SQ + Q + + L +Q VQ + QQ + L++
Sbjct: 372 DSSIF-SQFDYQDADKALTLVRSVLTRRRQAVQ-------DLRQQLAGCQEAVNLLQQQH 423
Query: 568 QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSD 627
Q +EE + Q+L+ E+ + + Q ++Q SLS + +LLQ+ RE L+
Sbjct: 424 DQWEEEGKALRQRLQKLTGER-DTLAGQTVDLQGEVDSLSKERELLQKAREELR------ 476
Query: 628 KTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLR 687
+ LE +LE+ R+ V L+ D SA +KE++ +L LAVRER ERL+
Sbjct: 477 QQLE----VLEQEAWRLRRVNVELQLQGD---SAQGQKEEQQEELHLAVRER----ERLQ 525
Query: 688 DVLSSNEATM-QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQL 746
++L EA +S+ L+ + E L ++ + L++E +T+ + E I +L
Sbjct: 526 EMLMGLEAKQSESLSELITLR----EALESSHLEGELLRQE-QTEVTAALARAEQSIAEL 580
Query: 747 QTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEM 806
+S + EV DL A + KL +A + N+Q+L+ E
Sbjct: 581 SSSENTLKTEVADLRAAAV-KLSALNEALALDKV---------------GLNQQLLQLEE 624
Query: 807 EIQGLLQSVSTREQESQ------AAAEKLVQALMERNSELQA---------------LRQ 845
E Q + + EQ A AEK +AL E+N+ L+A LR
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 846 YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 905
++ + + S Q E T Q +Q + +++ + +E ++ R
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATT-----QLEQLHQEAKRQEEVLARAVQEKEALVREKA 739
Query: 906 GDLDTVAGLEKELSNAKEELE-LMAKKE--RESQMELSALQSMMAVQEEELQVQAADMES 962
+ +E++ + E+L+ L + KE S E S++ V + +L+VQ +++
Sbjct: 740 ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ---IQT 796
Query: 963 LTRNIQIKEDLIKDLQMQLVDPEDIPAMER-----------------LTQEVLLLREKVA 1005
+T+ ++ + ++ L+++L ER L Q+ ++V
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVN 856
Query: 1006 SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRT 1065
+ + ++ +Q+L LE L E+ L L+ E+Q ++ E ++ +
Sbjct: 857 QLREKWEKERSWHQQELAKALESLEREKMELEMRLK-EQQTEMEAIQAQREEERTQAESA 915
Query: 1066 L-QVELEGAQVLRSRLEEVL 1084
L Q++LE + S LE +L
Sbjct: 916 LCQMQLETEKERVSLLETLL 935
Score = 86.7 bits (213), Expect = 1e-16
Identities = 157/701 (22%), Positives = 291/701 (41%), Gaps = 55/701 (7%)
Query: 325 GPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQ 384
GPS S + L+ K + +LQEL D L + L + LL
Sbjct: 1715 GPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 385 QKLNSHETTITQQSVSDSH-LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQD 443
Q+ E + QQ + ++ EL+E+ Q++ Q L + EL+ Q+ Q+
Sbjct: 1775 QR--EQEIVVLQQQLQEAREQGELKEQSLQSQLDEA--QRALAQRDQELEALQQEQQQAQ 1830
Query: 444 GTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVA 503
G + +KE + + E+ + ++ ++ + +E + L + + EG +
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR--LEEELAVEGRRVQALEEV 1888
Query: 504 LLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK-EASWKHNQE 562
L DL++ Q++ LA +QC + +A HE E + + SW Q
Sbjct: 1889 LGDLRA-------------ESREQEKALLALQQQCAE--QAQEHEVETRALQDSWLQAQA 1933
Query: 563 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 622
+ K Q E L+ +SQ R E ++ + + +L KEQ L E EL +
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 623 RDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHD 682
+ S TL+A+ + +++ + E I ++ +E +++QL+ A+ +RD +
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE---DVQQLQQALAQRDEE 2050
Query: 683 L--ERLRDVLSSNEATMQSMESLLRAK-GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 739
L ++ R+ L + E++++ K L E+ + L E++ + QKEQ
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA--QKEQ 2108
Query: 740 ESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNK 799
E I++ +T + +E L + QS + L RLQR+ LQ L
Sbjct: 2109 E-ILELRET---QQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEA 2164
Query: 800 QVLEHEMEIQGLLQSVSTRE---QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
+ +E + Q L S++ + Q A L +++ER+SE Q L+ L + +
Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEK 2224
Query: 857 APISNQQAEVTPTGCLGKQTDQGSM--QIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914
+ + A T T LG + +QG ++ + S E S + VA L
Sbjct: 2225 ERLHSPGA--TSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
Query: 915 EKELSN-AKEELELMAKKER-ESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKED 972
E + S + ++L + E+ E + ++M A Q L++ A S T+
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQ------- 2335
Query: 973 LIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE 1013
+D + Q D + L +EV+LL+ ++ Q Q+
Sbjct: 2336 --QDGRGQ--KNSDAKCVAELQKEVVLLQAQLTLERKQKQD 2372
Score = 85.5 bits (210), Expect = 3e-16
Identities = 197/966 (20%), Positives = 379/966 (39%), Gaps = 146/966 (15%)
Query: 232 SMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQAPQHGCNHKLELA 291
S ++ ++ESL+ + K+++TE A + + + QA C +LE
Sbjct: 867 SWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE--ERTQAESALCQMQLETE 924
Query: 292 ---LSMIKGLDYKPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTP 348
+S+++ L + S+ ++ + K T G+ L + + L +
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 349 VSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 408
+ +L+ LQE L +D + L+ Q E+L Q + +Q E+Q
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQ--VEDLKSQLVAQDDSQRLVEQ--------EVQ 1034
Query: 409 EKIQQTEATNKILQE----------KLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 458
EK+++T+ N+I +E L E L QE+ + + L++ ++ +
Sbjct: 1035 EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG 1094
Query: 459 ETEEL--------YQVIEGQNDTMAKLREMLHQSQLG-----QLHSS---EGTSPAQQQV 502
E +EL +V E + D +A+ ++L + + QL +S + AQ Q+
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 503 ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ---------------------- 540
L +S L E Q + Q + QLA +Q
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQA--QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPS 1212
Query: 541 ------------------------FVEAAAHESEQQKEASWKHNQE---LRKALQQLQEE 573
EA A + + WK Q LR +Q+L+E
Sbjct: 1213 VWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER 1272
Query: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEAN 633
L + + E + R QN + + + L E EL + + L
Sbjct: 1273 LTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA 1332
Query: 634 EM----------LLEKLRQRIHDKAVALERAIDE---KFSALEEKEKELRQLRLAVRERD 680
E+ LL+ ++ + + L+ A+ E + SA E++LR R A++ ++
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKN 1392
Query: 681 HDLERLRDVLSSNEATMQSMESLLRAKGLEV-EQLSTTCQNLQWLKEEMET------KFS 733
++E R+ +Q L A+G + E L+ Q L +EE+ET +
Sbjct: 1393 EEVESERE----RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 734 RWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI------AEELCQRLQRKE 787
+ ++ Q++ ++ L L RN+EV DL + +L +S + +E Q+L +
Sbjct: 1449 KQREMQKAALELLSLDLKKRNQEV-DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507
Query: 788 RMLQDLLSDRNKQ--VLEHE-MEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 844
+++L DR Q VLEH+ +E++ Q + ++ + Q ++LV L EL+
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV-TLECLALELEENH 1566
Query: 845 QYLGGRDSLMSQAPISNQQAEVTPTGCL------GKQTDQGSMQIPSRDDSTSLTAKEDV 898
+ + L+ + + V T ++ S QI + +++ A+E
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 899 SIPRSTLGDLDTVAGLEKELSNAKEEL-----ELMAKKERESQMELSALQSMMAVQEEEL 953
+ + + L+++ + ++L ELM +KER +E + EE+L
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLE-DQRTRQTKILEEDL 1685
Query: 954 QVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE 1013
+ + R + + L+++ + P L L+LR+K VE Q +
Sbjct: 1686 EQIKLSLRERGRELTTQRQLMQERAEEGKGPSK-AQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 1014 IS--GNRRQQLLLMLEGL---VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQV 1068
I + QL L+GL V E S L + E + ++ A + ++++LQ
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ-EAREQGELKEQSLQS 1803
Query: 1069 ELEGAQ 1074
+L+ AQ
Sbjct: 1804 QLDEAQ 1809
Score = 65.1 bits (157), Expect = 4e-10
Identities = 133/601 (22%), Positives = 232/601 (38%), Gaps = 63/601 (10%)
Query: 542 VEAAAHESEQQKEASW---KHNQELRKALQQLQEELQNKSQQLRAW--EAEKYNE----- 591
V A + + + ASW K++QE ++ L +LQ K Q R+W E EK E
Sbjct: 24 VLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGP 83
Query: 592 IRTQEQNIQ--HLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAV 649
I + +N++ +L+ L E+ Q L + +E +++ + LR+ + V
Sbjct: 84 IPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTV 143
Query: 650 ALERAIDEKFSALEEKEKELRQLRLAVR-ERDHDLERLRDVLSSN----EATMQSMESLL 704
RA DE + + E + ++ E L R+V++ E + L+
Sbjct: 144 DWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLM 203
Query: 705 RAKGLEVE---QLSTTCQNLQWLKEEMETKFS-RWQKEQESIIQQLQTSLHDRNKEVEDL 760
K V L T C L + E S R + + + L + KE +
Sbjct: 204 ELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHER 263
Query: 761 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 820
S L+ G E AE LQ + L LL+ KQ ++E I+ L ++V E
Sbjct: 264 SQELIQLKSQGDLEKAE-----LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILET 318
Query: 821 ESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGS 880
E E +L+Q + +M + G QGS
Sbjct: 319 NHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEE---------------GDNIAQGS 363
Query: 881 MQIPSRDDSTSLTAKED-------VSIPRSTL-GDLDTVAGLEKELSNAKEELELMAKKE 932
S + +S+ ++ D +++ RS L V L ++L+ +E + L+ ++
Sbjct: 364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH 423
Query: 933 RESQMELSALQ---SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPA 989
+ + E AL+ + + + L Q D++ ++ + +L++ + +L
Sbjct: 424 DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-----Q 478
Query: 990 MERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQA----ERQ 1045
+E L QE LR ++ QG G + +Q L V ER RL E L + +
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQ-QEELHLAVRERERLQEMLMGLEAKQSE 537
Query: 1046 LYSSLVKFHAHPESSERD-RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAA 1104
S L+ ESS + L+ E +R E+ + N L+T A AA
Sbjct: 538 SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597
Query: 1105 A 1105
A
Sbjct: 598 A 598
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 103 bits (258), Expect = 7e-22
Identities = 184/835 (22%), Positives = 351/835 (42%), Gaps = 113/835 (13%)
Query: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR--VQPMTEELLKQQKLNSHETTI 394
L++ ++ L V L + Q L DL ++ L ++ + E +Q K+ E
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
Query: 395 TQQSVSDSHLAE---LQEKIQQTEATNKILQEKLNEMSYEL----------KCAQESSQK 441
Q+VS + +++ E NKIL E + E S +L K E ++
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 442 QDGTIQNLKETLKSRERETE-------------ELYQVIEGQNDTMAKLREMLHQS---- 484
+ + L+ L E+E E E + +E +N + + L ++
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 485 -----QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCV 539
QL L E + ++ + L +L C+ +++ +LQ ++ E + K+ +
Sbjct: 683 KNLTFQLESLEK-ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 540 QFVEAAAHESEQQKEASWK----HNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 595
+ ++A+ ++E+ E S++ NQ L+K L+ +++Q +L+ E E +T
Sbjct: 742 ELLKASFKKTERL-EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN----QTL 796
Query: 596 EQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAI 655
++N++ L S EQL +E + L Q +K + E ++LRQ+ K LE
Sbjct: 797 QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN- 855
Query: 656 DEKFSALEEKEKELRQ---------LRLAVRERDH------------DLERLRDVLSSNE 694
+ K LE++ K L + +RL E+++ L LR+ L S +
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 695 ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRN 754
Q M + L E+E++ + L L +E T SR++ + + L+ SL +
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERL--LHDEQSTDDSRYKLLESKLESTLKKSLEIKE 973
Query: 755 KEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQ-VLEHEMEIQGLLQ 813
+++ L A L + ++L Q L+ ++ + L ++++ +++ I G
Sbjct: 974 EKIAALEARL-----EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 814 SVSTREQESQAAAEKLVQALME---RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG 870
QE+ K+ L+E N+ LQA +Q L + + + +N QA++
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL-ETQNNNLQAQI---- 1083
Query: 871 CLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTV-----AGLEKELSNAKEEL 925
L Q S+Q ++T T + + STL T A L + S+ + E
Sbjct: 1084 -LALQRQTVSLQ---EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 926 ELMAKKERESQMELSALQSMMAVQEEELQV----QAADMESLTRNIQIKEDLIKDLQMQL 981
E + KERE +L +L + E+L++ QA++ ESL + K+L+++
Sbjct: 1140 ESVI-KERE---DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
Query: 982 VDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQ 1041
D ED + L EK+ VE + + + + + L E RLN
Sbjct: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT-- 1253
Query: 1042 AERQLYSSLVKFHAHPESSERD-RTLQVELEGAQVLRSRLEEVLGRSLERLNRLE 1095
YS L+K E + D + L+ L +++ ++RLE + E+ +L+
Sbjct: 1254 -----YSQLLK---ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1300
Score = 85.1 bits (209), Expect = 3e-16
Identities = 145/664 (21%), Positives = 286/664 (43%), Gaps = 90/664 (13%)
Query: 448 NLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDL 507
+LK + R+ +E + ++ E ++ L + H S Q S G+ ++ + L
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDG----LHFLPHASSSAQ--SPCGSPGMKRTESRQHL 249
Query: 508 QSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKAL 567
L ++ +I++L++ + +K QL D KQ ++ +E L
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE---------------------L 288
Query: 568 QQLQEELQNKSQQLRA--WEAEKYNEIRTQEQNIQHLNHSLS-HKEQLLQEFRELLQYRD 624
++LQ+E N R+ ++ + +R + + L +S +KE+L ++ Y+
Sbjct: 289 KRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL----HDIEFYKA 344
Query: 625 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR-QLRLAVRERDHDL 683
++ E N++LLE + + D+ RA +K LE++ +L+ +L ERD D
Sbjct: 345 RVEELKEDNQVLLE-TKTMLEDQLEG-TRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 684 ERLRDVLSSN----EATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE- 738
+++ +++ N A QSM+ L G E+EQ+S T + L E + E
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHL-GWELEQISRTSE----LSEAPQKSLGHEVNEL 457
Query: 739 QESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI-AEELCQRLQRKERMLQDLLSDR 797
S + +L+ K VE+L T+ G + E+ QRL +K +L++
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN----- 512
Query: 798 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE-----LQALRQYLGGRDS 852
++++ + +Q Q++S + +A EK ++ L E NSE L+ ++L S
Sbjct: 513 --EIVQEKQSLQN-CQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQENEHLNQTVS 568
Query: 853 LMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVA 912
+ Q + +A V K + + S+ ++ +
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628
Query: 913 GLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKED 972
LE EL + ++E EL+ KK ++ + E L+ + +++E R ++ D
Sbjct: 629 ELENELHHLEKENELLQKKITNLKITCEKI--------EALEQENSELERENRKLKKTLD 680
Query: 973 LIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE 1032
K+L QL E +L +E L LR V S++ +++ QL L + L E
Sbjct: 681 SFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMA-----QLQLENKELESE 733
Query: 1033 RSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLN 1092
+ +L + L+ L+K S ++ L+V +G + RL++ L S +++
Sbjct: 734 KEQLKKGLE--------LLK-----ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 1093 RLET 1096
+LE+
Sbjct: 781 QLES 784
Score = 82.0 bits (201), Expect = 3e-15
Identities = 144/779 (18%), Positives = 337/779 (43%), Gaps = 82/779 (10%)
Query: 357 DLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK---IQQ 413
+L+E + L + L + + L+Q+ +N + + D L L+EK + +
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE-LDALREKAVRVDK 324
Query: 414 TEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN---LKETLKSRERETEELYQVIEGQ 470
E+ +E+L+++ + +E + ++ L++ L+ +++L+++ +
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 471 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQ-KLQRVVRQKE 529
AKL +M + + + E ++ + L Q L + +L+++ R E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEE---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 530 RQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKY 589
L++A Q ++ HE + + + ++L + EEL+ +
Sbjct: 442 --LSEAPQ-----KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG----NA 490
Query: 590 NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAV 649
++I E+ Q L+ + E + + ++ LQ N K L + LEK + + + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS- 549
Query: 650 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGL 709
+ + LE++ + L Q ++R+R S EA ++ +E +
Sbjct: 550 ------ERQIKILEQENEHLNQTVSSLRQRSQ---------ISAEARVKDIEKENKILHE 594
Query: 710 EVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL-CKL 768
+++ S+ +++ K +++ + + KE+ ++L+ LH KE E L + K+
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHY-KEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 769 GPGQSEIAEELCQRLQRKERMLQ-------------DLLSDRNKQVLEHEMEIQGLLQSV 815
+ E E+ L+R+ R L+ + L N Q+ E +E++ ++S+
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 816 STREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC-LGK 874
+ A+ K+ Q +E N EL++ ++ L L+ + ++ EV+ G +
Sbjct: 714 -------KCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 875 QTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG--------DLDTVAGLEKELSNAKEELE 926
Q Q +++ ++ + +D+ + TL + LEKE + ++E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 927 LMAKKERESQMELSALQSMMAVQE---EELQVQAADMESLTRNIQIKEDLIKD--LQMQL 981
+ K +++ + E L+ +++ EE V+ ++E + + + + K+ ++++
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 982 VDPEDIPAMERLTQEV---LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNE 1038
++ E+ ++R T ++ + LRE + S + + Q+++ N ++L LE + + RL
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN-NDLEKLTHELEKIGLNKERL-- 942
Query: 1039 ALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETL 1097
L E+ S K S ++L+++ E L +RLEE + + L+T+
Sbjct: 943 -LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 1000
Score = 57.0 bits (136), Expect = 1e-07
Identities = 102/506 (20%), Positives = 214/506 (42%), Gaps = 81/506 (16%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEEL------LKQQKLNSHETTITQQSVSDSHLAE 406
+++ L L +DL + L+ Q M +L L++ LN +QS DS
Sbjct: 899 IDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 407 LQEKIQQT-EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLKSRERE--- 459
L+ K++ T + + +I +EK+ + L+ + +Q+ ++ +K E LK R+ E
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 460 ---------------------TEELYQV------IEGQNDTMAKLREMLHQSQLGQLHSS 492
T EL +V +E N T+ ++ L ++QL QL +
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL-KTQLKQLETQ 1075
Query: 493 EGTSPAQ------QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 546
AQ Q V+L + + L ++Q + + L + + +++
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135
Query: 547 HESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNH 604
E + E+ K ++L+ L ++ K + L +A +Y + ++ ++ H N
Sbjct: 1136 ---ENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKNL 1191
Query: 605 SLSHKEQLLQEFRELLQYR---DNSDKTL--EANEMLLEKLRQRIHDKAVALERAIDEKF 659
+ H++ L + +LL+ + ++ +K L E +MLLE + H+ A + + +
Sbjct: 1192 EVEHRD-LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN---KNHETVAAEYKKLCGEN 1247
Query: 660 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 719
L +L + V + DH + L+ +L++++ +E+ + +QL T
Sbjct: 1248 DRLNHTYSQLLK-ETEVLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 720 NLQWLKEEMETKFSRWQKEQESIIQQLQT------SLHDRNKEVEDLSATLLCKLGPGQS 773
L E + ++E ++ Q+QT +L ++N E +DL Q
Sbjct: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL-------FHVEQR 1357
Query: 774 EIAEELCQRLQRKERMLQDLLSDRNK 799
+ ++L L+R++ L++ + D+ K
Sbjct: 1358 QYIDKL-NELRRQKEKLEEKIMDQYK 1382
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 103 bits (257), Expect = 9e-22
Identities = 116/488 (23%), Positives = 224/488 (45%), Gaps = 43/488 (8%)
Query: 341 LKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS 400
+K +++ ++ L L + L ++L L L+ + + LK++K + ++VS
Sbjct: 202 MKKMHEGDLAMALVLDEKDRLIEEL---KLSLKSKEALIQCLKEEK---SQMACPDENVS 255
Query: 401 DSHLAEL-----QEKIQQTEATN--------------KILQEKLNEMSYELKCAQESSQK 441
L L +EK ++TEA + L+E L E E+ +++S K
Sbjct: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
Query: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQ 499
+D IQ L LKS+E++ EEL IE + AK RE L ++Q + SE T+ +
Sbjct: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
Query: 500 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 559
++ L+S E +L+R +++ ++L+D +Q + +E E+ ++K
Sbjct: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
Query: 560 NQELRKALQQLQEELQNKSQQL----RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 615
++LR +++L+ E+ + + + ++ +E ++ QEQ I+HL S + K+ LLQ+
Sbjct: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
Query: 616 FRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA 675
F E + L A E L + I +K + + + + E+K+ + +
Sbjct: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
Query: 676 VRERDHDL-----ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
V +++ D+ + L++ S N + + K LE + LS QNL+ EE +
Sbjct: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS--YQNLRKTLEEQIS 613
Query: 731 KFSRWQKEQESIIQQ----LQTSLHDRNK-EVEDLSATLLCKLGPGQSEIAEELCQRLQR 785
+ R ++E S+ L L + N+ +VE S L K ++ +EL Q
Sbjct: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
Query: 786 KERMLQDL 793
++ + DL
Sbjct: 674 LKKTIFDL 681
Score = 69.7 bits (169), Expect = 1e-11
Identities = 144/712 (20%), Positives = 296/712 (41%), Gaps = 119/712 (16%)
Query: 315 VKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRV 374
V L G P + +G+ ++ P + + D + +L ++ L++
Sbjct: 26 VPDDLDGINPNAGLGNGLLPNVSEETVSP------TRARNMKDFENQITELKKENFNLKL 79
Query: 375 QPMTEELLKQQKLNS-----HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429
+ E QQ+ + ++T I + +S ELQE+ Q +K ++
Sbjct: 80 RIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGG 139
Query: 430 YELKCAQESSQKQDGTIQNL--------KETLKSRERETEELYQVIEGQNDTMAKLREML 481
E++ +E ++K+ +++L ++ + + + E E+ + E + +L L
Sbjct: 140 SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKL 199
Query: 482 HQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQC 538
S++ ++H + ++ + +L+ +L + IQ L ++++ Q+A +
Sbjct: 200 --SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL----KEEKSQMACPDEN 253
Query: 539 VQFVE------AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQLRAWEAEK 588
V E A E E++ EA+ +Q+ R + +Q L+E+L+ K +++ EK
Sbjct: 254 VSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT---EK 310
Query: 589 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
N ++ +++ IQ L +L KE+ ++E NS+ +EKL
Sbjct: 311 KNSLK-RDKAIQGLTMALKSKEKKVEEL--------NSE---------IEKLSAAFAKAR 352
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
AL++A ++F E+ E L E L L S T + LR
Sbjct: 353 EALQKAQTQEFQGSEDYETALS-----------GKEALSAALRSQNLTKSTENHRLRRS- 400
Query: 709 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 768
+++++ +LQ +E +E +E+ + ++ D EVE L
Sbjct: 401 --IKKITQELSDLQQERERLEKDLEEAHREKS----KGDCTIRDLRNEVEKLR------- 447
Query: 769 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 828
E+ +R + E + LLS+ NK++ E I+ L +S + ++ Q EK
Sbjct: 448 --------NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
Query: 829 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGS-----MQI 883
++ ++++N L A + L+++ S+QQ + T K+ Q S +Q+
Sbjct: 500 DLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQPPGSKT-IFSKEKKQSSDYEELIQV 556
Query: 884 --PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKEL-----------SNAKEELELM 928
+D T L + +E SI + +L+ + L K+L +E++ +
Sbjct: 557 LKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
Query: 929 AKKERESQMELSALQSMMAVQEEE---LQVQAADMESLTRNIQIKEDLIKDL 977
++E ES S S +++ EE QV+ E L + + L+K+L
Sbjct: 616 RRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/290 (21%), Positives = 115/290 (39%), Gaps = 47/290 (16%)
Query: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR-VQPMTEELLKQQKLNSHETTIT 395
L L+ L+ S +E++ EL + + ED L + + P + E L+ +ET+
Sbjct: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS-- 1365
Query: 396 QQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L++
Sbjct: 1366 ----EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
Query: 452 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 511
L ER+ E ++G A E LH S ++H + A L + L
Sbjct: 1422 QL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNAML 1466
Query: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 571
+ QK +R ES +K S +H Q ++++
Sbjct: 1467 IKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKEEN 1505
Query: 572 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 621
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
Score = 36.2 bits (82), Expect = 0.18
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 631
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 632 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 676
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 857 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 915 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 974
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 975 KDLQMQLVDPEDIPAMERLTQEVLLLRE 1002
+ L+++L A E+L +E LR+
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
Score = 36.2 bits (82), Expect = 0.18
Identities = 81/401 (20%), Positives = 156/401 (38%), Gaps = 48/401 (11%)
Query: 354 ELSDLQELWDDLCEDYLPLRVQPMTEELL--KQQKLNSHETTITQQSVSDSHLAELQEKI 411
E+ +LQ + DL VQ EL +QQ + H + + ++ + +E +
Sbjct: 1226 EIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELL 1285
Query: 412 QQTEATNKI---LQEKLNEMSYELKCAQES--SQKQDGTIQNLKETLKSRERETEELYQV 466
Q ++ + QE+LN+ + L+ ++ + K G N + L R E YQ
Sbjct: 1286 QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQH 1345
Query: 467 IEGQN------------DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD----LQSA 510
+ ++ +T K Q Q + + + Q L++ +++
Sbjct: 1346 LLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405
Query: 511 LFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHE--SEQQKEASW--KHNQELRKA 566
+ I+ +++ +Q ERQ ++ Q + A+ E S E + K NQ L
Sbjct: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465
Query: 567 L-----------QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-HKEQLLQ 614
L +L+E L K+ L + E Y ++ + + +Q H +QL+Q
Sbjct: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQRE-YASVKEENERLQKEGSEKERHNQQLIQ 1524
Query: 615 EFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRL 674
E R Q + ++ + LL + +DK + R + + L+E+ + LR
Sbjct: 1525 EVRCSGQELSRVQEEVKLRQQLLSQ-----NDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
Query: 675 AVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLS 715
E D+ + SS T +S+ G + + LS
Sbjct: 1580 YPMESDNSFDLFD---SSQAVTPKSVSETPPLSGNDTDSLS 1617
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 103 bits (257), Expect = 9e-22
Identities = 116/488 (23%), Positives = 224/488 (45%), Gaps = 43/488 (8%)
Query: 341 LKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS 400
+K +++ ++ L L + L ++L L L+ + + LK++K + ++VS
Sbjct: 202 MKKMHEGDLAMALVLDEKDRLIEEL---KLSLKSKEALIQCLKEEK---SQMACPDENVS 255
Query: 401 DSHLAEL-----QEKIQQTEATN--------------KILQEKLNEMSYELKCAQESSQK 441
L L +EK ++TEA + L+E L E E+ +++S K
Sbjct: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
Query: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQ 499
+D IQ L LKS+E++ EEL IE + AK RE L ++Q + SE T+ +
Sbjct: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
Query: 500 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 559
++ L+S E +L+R +++ ++L+D +Q + +E E+ ++K
Sbjct: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
Query: 560 NQELRKALQQLQEELQNKSQQL----RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 615
++LR +++L+ E+ + + + ++ +E ++ QEQ I+HL S + K+ LLQ+
Sbjct: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
Query: 616 FRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA 675
F E + L A E L + I +K + + + + E+K+ + +
Sbjct: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
Query: 676 VRERDHDL-----ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
V +++ D+ + L++ S N + + K LE + LS QNL+ EE +
Sbjct: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS--YQNLRKTLEEQIS 613
Query: 731 KFSRWQKEQESIIQQ----LQTSLHDRNK-EVEDLSATLLCKLGPGQSEIAEELCQRLQR 785
+ R ++E S+ L L + N+ +VE S L K ++ +EL Q
Sbjct: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
Query: 786 KERMLQDL 793
++ + DL
Sbjct: 674 LKKTIFDL 681
Score = 69.7 bits (169), Expect = 1e-11
Identities = 144/712 (20%), Positives = 296/712 (41%), Gaps = 119/712 (16%)
Query: 315 VKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRV 374
V L G P + +G+ ++ P + + D + +L ++ L++
Sbjct: 26 VPDDLDGINPNAGLGNGLLPNVSEETVSP------TRARNMKDFENQITELKKENFNLKL 79
Query: 375 QPMTEELLKQQKLNS-----HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429
+ E QQ+ + ++T I + +S ELQE+ Q +K ++
Sbjct: 80 RIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGG 139
Query: 430 YELKCAQESSQKQDGTIQNL--------KETLKSRERETEELYQVIEGQNDTMAKLREML 481
E++ +E ++K+ +++L ++ + + + E E+ + E + +L L
Sbjct: 140 SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKL 199
Query: 482 HQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQC 538
S++ ++H + ++ + +L+ +L + IQ L ++++ Q+A +
Sbjct: 200 --SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL----KEEKSQMACPDEN 253
Query: 539 VQFVE------AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQLRAWEAEK 588
V E A E E++ EA+ +Q+ R + +Q L+E+L+ K +++ EK
Sbjct: 254 VSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT---EK 310
Query: 589 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
N ++ +++ IQ L +L KE+ ++E NS+ +EKL
Sbjct: 311 KNSLK-RDKAIQGLTMALKSKEKKVEEL--------NSE---------IEKLSAAFAKAR 352
Query: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
AL++A ++F E+ E L E L L S T + LR
Sbjct: 353 EALQKAQTQEFQGSEDYETALS-----------GKEALSAALRSQNLTKSTENHRLRRS- 400
Query: 709 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 768
+++++ +LQ +E +E +E+ + ++ D EVE L
Sbjct: 401 --IKKITQELSDLQQERERLEKDLEEAHREKS----KGDCTIRDLRNEVEKLR------- 447
Query: 769 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 828
E+ +R + E + LLS+ NK++ E I+ L +S + ++ Q EK
Sbjct: 448 --------NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
Query: 829 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGS-----MQI 883
++ ++++N L A + L+++ S+QQ + T K+ Q S +Q+
Sbjct: 500 DLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQPPGSKT-IFSKEKKQSSDYEELIQV 556
Query: 884 --PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKEL-----------SNAKEELELM 928
+D T L + +E SI + +L+ + L K+L +E++ +
Sbjct: 557 LKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
Query: 929 AKKERESQMELSALQSMMAVQEEE---LQVQAADMESLTRNIQIKEDLIKDL 977
++E ES S S +++ EE QV+ E L + + L+K+L
Sbjct: 616 RRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
Score = 45.4 bits (106), Expect = 3e-04
Identities = 84/382 (21%), Positives = 152/382 (39%), Gaps = 63/382 (16%)
Query: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR-VQPMTEELLKQQKLNSHETTIT 395
L L+ L+ S +E++ EL + + ED L + + P + E L+ +ET+
Sbjct: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS-- 1365
Query: 396 QQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L++
Sbjct: 1366 ----EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
Query: 452 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 511
L ER+ E ++G A E LH S ++H + A L + L
Sbjct: 1422 QL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNAML 1466
Query: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 571
+ QK +R ES +K S +H Q ++++
Sbjct: 1467 IKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKEEN 1505
Query: 572 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE 631
E LQ + + + E+R Q + + + ++QLL + +LLQ + L+
Sbjct: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVELK 1562
Query: 632 ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 691
A E L E+ R+ L A E + ++ ++L L + ++ LER + S
Sbjct: 1563 AYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIETSS 1613
Query: 692 SNEATMQSMESLLRAKGLEVEQ 713
T+QS A+G E Q
Sbjct: 1614 ----TLQSRLKEQLARGAEKAQ 1631
Score = 40.4 bits (93), Expect = 0.010
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 631
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 632 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 676
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 857 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 915 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 974
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 975 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
Query: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 1075
+L +++ L S L + A ++ L + ++ +
Sbjct: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 102 bits (255), Expect = 2e-21
Identities = 153/793 (19%), Positives = 323/793 (40%), Gaps = 103/793 (12%)
Query: 408 QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 467
QE I E + ++EKL + +EL Q + ++ +K + EEL + I
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 468 EGQNDTMAKL--------REMLHQSQLGQLHSSEGTSPAQ------QQVALLDLQSALFC 513
E ++ AK+ RE+ S+ +L + G + AQ ++ ++ L
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISE--RLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 514 SQLEIQKLQRVVRQKER-QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 572
+ L+ + +R+K+ +A+ + + ++ + E++K ++ ++ L +
Sbjct: 1185 ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSK 1244
Query: 573 ELQNKSQQLRAWEAEKYNEIRT--------------QEQNIQHLNHSLSH---------- 608
N + R E ++++EI+ Q+ +Q N LSH
Sbjct: 1245 SKSNIERTCRTVE-DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLIS 1303
Query: 609 -----KEQLLQEFRELLQYRDNSDKTLEANEMLLEK-------LRQRIHDKAVA---LER 653
K+ L Q+ EL + + K A L+ LR++ ++ A L+R
Sbjct: 1304 QLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 654 AIDEKFSAL---------------EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ 698
A+ + S + EE E+ ++L ++E + + E +S E T Q
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423
Query: 699 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 758
++ + ++E+ T C L + + + W+++ + + Q L KE
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQK----LDESQAELEAAQKESR 1479
Query: 759 DLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTR 818
LS T L K+ E+ ++L + L+R+ + LQ+ +SD +Q+ E +Q ++
Sbjct: 1480 SLS-TELFKMRNAYEEVVDQL-ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537
Query: 819 EQES---QAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQ 875
EQE Q A E++ +L S++ ++ L S + + I + E+ L +
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE-EIEQ---LKRN 1593
Query: 876 TDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERES 935
+ + + + S D+ + + + + + GDL+ +E +L ++ ++ E+
Sbjct: 1594 SQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE---MEIQLGHSNRQM-------AET 1643
Query: 936 QMELSALQSMMAVQEEELQVQAADMESLTRNIQIKED----LIKDLQMQLVDPEDIPAME 991
Q L +Q + + L E L + I E L+++L+ V E
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 992 RLT-QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSL 1050
RL+ QE+L ++V + SQ + +++ + + + + + E+ AE + ++
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 1051 VKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTE 1110
E ++++ LE ++ LE+ + RL+ E LA GG E
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 1111 DTSTEFTDSIEEE 1123
+ E + ++ E
Sbjct: 1821 NRVRELENELDVE 1833
Score = 95.1 bits (235), Expect = 3e-19
Identities = 163/803 (20%), Positives = 358/803 (44%), Gaps = 127/803 (15%)
Query: 355 LSDLQELWDDLCEDYLPL--RVQPMTEELLKQQKLNSH----------ETTITQQSVSDS 402
L D +E + L + + L +V+ +TE L +++++NS + + ++ + D
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL 961
Query: 403 HLAELQEKIQQTEATNKI---------LQEKLNEMSYELKCAQESSQK-------QDGTI 446
L + + ++ NK+ L+E +++++ E K QE+ Q+ ++ +
Sbjct: 962 ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 447 QNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD 506
L + E++T++L EG + KLR L +++ EG Q+ +++D
Sbjct: 1022 NGLIKINAKLEQQTDDL----EGSLEQEKKLRADLERAK----RKLEGDLKMSQE-SIMD 1072
Query: 507 LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKA 566
L++ + Q+++ +++KE +L+ + + + H + QK+ +EL+
Sbjct: 1073 LEN-------DKQQIEEKLKKKEFELSQLQAKID--DEQVHSLQFQKKI-----KELQAR 1118
Query: 567 LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHS-------LSHKEQLLQEFREL 619
+++L+EE++ + E ++ + R E+ + L + + ++ EF+++
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178
Query: 620 LQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 679
RD + TL+ +E LR++ D L ID ++ EKE +L++ + +
Sbjct: 1179 --RRDLEEATLQ-HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 680 DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET---KFSRWQ 736
++E L S+ E T +++E + EQ + +L K ++T + S
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
+E+ES+I QL S +++E+L + +++ + LQ R DLL +
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQM-----EEETKAKNAMAHALQ-SSRHDCDLLRE 1349
Query: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
+ ++ E + E+Q +++S E K ++R EL+ ++ L R + +
Sbjct: 1350 QYEEEQEAKAELQ---RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR---LQE 1403
Query: 857 APISNQQAEVTPTGCLG----KQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVA 912
A + E + C KQ QG ++ RD S TA + + + +A
Sbjct: 1404 A---EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV--LA 1458
Query: 913 GLEKELSNAKEELELMAKKERESQMELSALQS----------MMAVQEEELQVQAADM-- 960
+++L ++ ELE K+ R EL +++ + + + LQ + +D+
Sbjct: 1459 EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTE 1518
Query: 961 --ESLTRNIQIKEDLIK-------DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQ- 1010
+N+Q E K DLQ+ L + E ++E ++L ++ +++ V+S+
Sbjct: 1519 QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG--SLEHEESKILRVQLELSQVKSEL 1576
Query: 1011 -------GQEISGNRR--QQLLLMLEGLVDERSR-LNEALQAERQLYSSLVKF-----HA 1055
+EI +R Q+ L+ ++D R N+AL+ ++++ L + H+
Sbjct: 1577 DRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHS 1636
Query: 1056 HPESSERD---RTLQVELEGAQV 1075
+ + +E RT+Q +L+ +Q+
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQL 1659
Score = 74.7 bits (182), Expect = 5e-13
Identities = 125/643 (19%), Positives = 261/643 (40%), Gaps = 88/643 (13%)
Query: 449 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ 508
+K LKS E E E + + + +E L +S+ + E + V+LL +
Sbjct: 840 IKPLLKSAEAEKE-----MATMKEDFERTKEELARSEARRKELEE------KMVSLLQEK 888
Query: 509 SALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQ 568
+ L QL++Q + E + + +EA E ++ E + N EL +
Sbjct: 889 NDL---QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 569 QLQEELQNKSQQLRAWE---AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRD 624
L+++ + + + E + E E +++L+ ++ E+ + + +E ++
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Query: 625 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 684
+TL+ ++ +K+ I A LE+ D+ +LE+++K L A R+ + DL+
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLIKINA-KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 685 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 744
++ + E Q +E L+ K E+ QL + Q + + K I+
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK-----------IK 1113
Query: 745 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 804
+LQ + + +E+E TL K+ +S++A E
Sbjct: 1114 ELQARIEELEEEIE-AEHTLRAKIEKQRSDLARE-------------------------- 1146
Query: 805 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 864
L+ +S R +E+ A ++ +R +E Q +R RD + +A + ++
Sbjct: 1147 -------LEEISERLEEASGATSAQIEMNKKREAEFQKMR-----RD--LEEATLQHEAT 1192
Query: 865 EVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG-DLDTVAGLEKELSNAKE 923
T L K+ ++ + D+ K+ + +S L ++D +A + LS +K
Sbjct: 1193 AAT----LRKKQADSVAELGEQIDNLQ-RVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 924 ELELMAKKERESQMELSALQSMMAVQEEELQVQAADMES----LTRNIQIKEDLIKDLQM 979
+E + + E+ A +L +Q A +++ L+ ++ KE LI L
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL-- 1305
Query: 980 QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEA 1039
+ A+ + +E+ E+ ++ + R L+ E +E+ E
Sbjct: 1306 ----TKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 1040 LQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1082
+A + S + ++ E+ RT ++E E + L RL+E
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQRTEELE-EAKKKLAQRLQE 1403
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 101 bits (252), Expect = 4e-21
Identities = 184/838 (21%), Positives = 351/838 (41%), Gaps = 120/838 (14%)
Query: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR--VQPMTEELLKQQKLNSHETTI 394
L++ ++ L V L + Q L DL ++ L ++ + E +Q K+ E
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
Query: 395 TQQSVSDSHLAE---LQEKIQQTEATNKILQEKLNEMSYEL----------KCAQESSQK 441
Q+VS + +++ E NKIL E + E S +L K E ++
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 442 QDGTIQNLKETLKSRERETE-------------ELYQVIEGQNDTMAKLREMLHQS---- 484
+ + L+ L E+E E E + +E +N + + L ++
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 485 -----QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCV 539
QL L E + ++ + L +L C+ +++ +LQ ++ E + K+ +
Sbjct: 683 KNLTFQLESLEK-ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 540 QFVEAAAHESEQQKEASWK----HNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 595
+ ++A+ ++E+ E S++ NQ L+K L+ +++Q +L+ E E +T
Sbjct: 742 ELLKASFKKTERL-EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN----QTL 796
Query: 596 EQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAI 655
++N++ L S EQL +E + L + LE ++ LEK +R+ +A + +
Sbjct: 797 QKNLEELKISSKRLEQLEKENKSL----EQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 656 DEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLS 715
+E + EKE + L + RL+++ N + L++ ++++ L
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-------KELVKRATIDIKTLV 905
Query: 716 TTCQNLQWLK---EEMETKFSRWQKEQESIIQQLQTSLH------DRNKEVED-LSATLL 765
T ++L K ++M + E E I + LH DR K +E L +TL
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK 965
Query: 766 CKLGPGQSEIAEELCQRLQRKERMLQDLLSD-----RNKQVLEHEMEIQGLLQSV----- 815
L + +IA L RL+ Q L + +N + L+ + + ++QS
Sbjct: 966 KSLEIKEEKIA-ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024
Query: 816 --STREQESQAAAEKLVQA------LMERNSELQALRQYLGGRDSLMSQAPISNQQAEVT 867
+ E+ESQ +L++ + N+ LQA +Q L + + + +N QA++
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL-ETQNNNLQAQI- 1082
Query: 868 PTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTV-----AGLEKELSNAK 922
L Q S+Q ++T T + + STL T A L + S+ +
Sbjct: 1083 ----LALQRQTVSLQ---EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Query: 923 EELELMAKKERESQMELSALQSMMAVQEEELQV----QAADMESLTRNIQIKEDLIKDLQ 978
E E + KERE +L +L + E+L++ QA++ ESL + K+L+
Sbjct: 1136 NENESVI-KERE---DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE 1191
Query: 979 MQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNE 1038
++ D ED + L EK+ VE + + + + + L E RLN
Sbjct: 1192 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1251
Query: 1039 ALQAERQLYSSLVKFHAHPESSERD-RTLQVELEGAQVLRSRLEEVLGRSLERLNRLE 1095
YS L+K E + D + L+ L +++ ++RLE + E+ +L+
Sbjct: 1252 T-------YSQLLK---ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1299
Score = 85.1 bits (209), Expect = 3e-16
Identities = 145/664 (21%), Positives = 286/664 (43%), Gaps = 90/664 (13%)
Query: 448 NLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDL 507
+LK + R+ +E + ++ E ++ L + H S Q S G+ ++ + L
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDG----LHFLPHASSSAQ--SPCGSPGMKRTESRQHL 249
Query: 508 QSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKAL 567
L ++ +I++L++ + +K QL D KQ ++ +E L
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIE---------------------L 288
Query: 568 QQLQEELQNKSQQLRA--WEAEKYNEIRTQEQNIQHLNHSLS-HKEQLLQEFRELLQYRD 624
++LQ+E N R+ ++ + +R + + L +S +KE+L ++ Y+
Sbjct: 289 KRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL----HDIEFYKA 344
Query: 625 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR-QLRLAVRERDHDL 683
++ E N++LLE + + D+ RA +K LE++ +L+ +L ERD D
Sbjct: 345 RVEELKEDNQVLLE-TKTMLEDQLEG-TRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 684 ERLRDVLSSN----EATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKE- 738
+++ +++ N A QSM+ L G E+EQ+S T + L E + E
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHL-GWELEQISRTSE----LSEAPQKSLGHEVNEL 457
Query: 739 QESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI-AEELCQRLQRKERMLQDLLSDR 797
S + +L+ K VE+L T+ G + E+ QRL +K +L++
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN----- 512
Query: 798 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE-----LQALRQYLGGRDS 852
++++ + +Q Q++S + +A EK ++ L E NSE L+ ++L S
Sbjct: 513 --EIVQEKQSLQN-CQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQENEHLNQTVS 568
Query: 853 LMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVA 912
+ Q + +A V K + + S+ ++ +
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628
Query: 913 GLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKED 972
LE EL + ++E EL+ KK ++ + E L+ + +++E R ++ D
Sbjct: 629 ELENELHHLEKENELLQKKITNLKITCEKI--------EALEQENSELERENRKLKKTLD 680
Query: 973 LIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDE 1032
K+L QL E +L +E L LR V S++ +++ QL L + L E
Sbjct: 681 SFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMA-----QLQLENKELESE 733
Query: 1033 RSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLN 1092
+ +L + L+ L+K S ++ L+V +G + RL++ L S +++
Sbjct: 734 KEQLKKGLE--------LLK-----ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 1093 RLET 1096
+LE+
Sbjct: 781 QLES 784
Score = 80.1 bits (196), Expect = 1e-14
Identities = 144/779 (18%), Positives = 340/779 (43%), Gaps = 83/779 (10%)
Query: 357 DLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK---IQQ 413
+L+E + L + L + + L+Q+ +N + + D L L+EK + +
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE-LDALREKAVRVDK 324
Query: 414 TEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN---LKETLKSRERETEELYQVIEGQ 470
E+ +E+L+++ + +E + ++ L++ L+ +++L+++ +
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 471 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQ-KLQRVVRQKE 529
AKL +M + + + E ++ + L Q L + +L+++ R E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEE---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 530 RQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKY 589
L++A Q ++ HE + + + ++L + EEL+ +
Sbjct: 442 --LSEAPQ-----KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG----NA 490
Query: 590 NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAV 649
++I E+ Q L+ + E + + ++ LQ N K L + LEK + + + +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS- 549
Query: 650 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGL 709
+ + LE++ + L Q ++R+R S EA ++ +E +
Sbjct: 550 ------ERQIKILEQENEHLNQTVSSLRQRSQ---------ISAEARVKDIEKENKILHE 594
Query: 710 EVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL-CKL 768
+++ S+ +++ K +++ + + KE+ ++L+ LH KE E L + K+
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHY-KEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 769 GPGQSEIAEELCQRLQRKERMLQ-------------DLLSDRNKQVLEHEMEIQGLLQSV 815
+ E E+ L+R+ R L+ + L N Q+ E +E++ ++S+
Sbjct: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 816 STREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGC-LGK 874
+ A+ K+ Q +E N EL++ ++ L L+ + ++ EV+ G +
Sbjct: 714 -------KCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 875 QTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG--------DLDTVAGLEKELSNAKEELE 926
Q Q +++ ++ + +D+ + TL + LEKE + ++E
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 927 LMAKKERESQMELSALQSMMAVQE---EELQVQAADMESLTRNIQIKEDLIKD--LQMQL 981
+ K +++ + E L+ +++ EE V+ ++E + + + + K+ ++++
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 982 VDPEDIPAMERLTQEV---LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNE 1038
++ E+ ++R T ++ + LRE + S + + Q+++ N ++L LE + + RL
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN-NDLEKLTHELEKIGLNKERLLH 944
Query: 1039 ALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETL 1097
Q+ Y L + ES+ + ++L+++ E L +RLEE + + L+T+
Sbjct: 945 DEQSTDDRYKLL---ESKLESTLK-KSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Score = 57.8 bits (138), Expect = 6e-08
Identities = 131/681 (19%), Positives = 280/681 (41%), Gaps = 122/681 (17%)
Query: 353 LELSDLQELWDDLCEDYLPLRVQPMTEEL------LKQQKLNSHETTITQQSVSDSHLAE 406
+++ L L +DL + L+ Q M +L L++ LN +QS D +
Sbjct: 899 IDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL- 955
Query: 407 LQEKIQQT-EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLKSRERE--- 459
L+ K++ T + + +I +EK+ + L+ + +Q+ ++ +K E LK R+ E
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1015
Query: 460 ---------------------TEELYQV------IEGQNDTMAKLREMLHQSQLGQLHSS 492
T EL +V +E N T+ ++ L ++QL QL +
Sbjct: 1016 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL-KTQLKQLETQ 1074
Query: 493 EGTSPAQ------QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 546
AQ Q V+L + + L ++Q + + L + + +++
Sbjct: 1075 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1134
Query: 547 HESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ--HLNH 604
E + E+ K ++L+ L ++ K + L +A +Y + ++ ++ H N
Sbjct: 1135 ---ENENESVIKEREDLKSLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 605 SLSHKEQLLQEFRELLQYR---DNSDKTL--EANEMLLEKLRQRIHDKAVALERAIDEKF 659
+ H++ L + +LL+ + ++ +K L E +MLLE + H+ A + + +
Sbjct: 1191 EVEHRD-LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN---KNHETVAAEYKKLCGEN 1246
Query: 660 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 719
L +L + V + DH + L+ +L++++ +E+ + +QL T
Sbjct: 1247 DRLNHTYSQLLK-ETEVLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
Query: 720 NLQWLKEEMETKFSRWQKEQESIIQQLQT------SLHDRNKEVEDLSATLLCKLGPGQS 773
L E + ++E ++ Q+QT +L ++N E +DL Q
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL-------FHVEQR 1356
Query: 774 EIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL 833
+ ++L L+R++ L++ + D+ K +G ++ R KL+++
Sbjct: 1357 QYIDKL-NELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMR---------KLIKSK 1406
Query: 834 MERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLT 893
+ N E Q + +TPT + +G +Q+P +D
Sbjct: 1407 KDINRERQ--------------------KSLTLTPT---RSDSSEGFLQLPHQD------ 1437
Query: 894 AKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERE-SQMELSALQSMMAVQEEE 952
+++ S+ ++L D T+ G +K A + L + + ++ +M+ +SM +
Sbjct: 1438 SQDSSSVGSNSLEDGQTL-GTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQ 1496
Query: 953 LQVQAADMESLTRNIQIKEDL 973
V A T N+++ +D+
Sbjct: 1497 SMVLAGQWTGSTENLEVPDDI 1517
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 101 bits (252), Expect = 4e-21
Identities = 152/677 (22%), Positives = 292/677 (43%), Gaps = 67/677 (9%)
Query: 394 ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSY---ELKCAQESSQKQDGTIQN-L 449
+ Q+S +AELQ ++Q + ++E+ M EL+ +++ T+Q L
Sbjct: 613 LEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRL 672
Query: 450 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHS---SEGTSPAQQQVALLD 506
+E+ + EEL+QV + ++R++ Q QL ++H S S +++ AL++
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDL--QDQLSEMHDELDSAKRSEDREKGALIE 730
Query: 507 --LQSALFCSQLEIQKLQR--VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 562
LQ+ L I K ++ ++R++ER+L K + KE H+QE
Sbjct: 731 ELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL-------------KEEVSSHDQE 777
Query: 563 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH-KEQLLQEFRELLQ 621
+ K +Q ELQ + + EA K E+ N + + + + +LLQE E LQ
Sbjct: 778 MDKLKEQYDAELQALRESVE--EATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 622 YRDNSDKTLEANEMLLEKLRQRIHD------KAVALERAIDEKFSALEEK----EKELRQ 671
R E E + +L+++I D KA + + + LEE KE ++
Sbjct: 836 GRS------EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 672 LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 731
A R +++LE + LS + + L+ + + EQL ++ + +
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 732 FSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQ 791
+ QKE I++ +TS + ++++ + E+AE + Q KE+ L+
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKE-------KNRRELAE---MQRQLKEKTLE 999
Query: 792 DLLSDRNKQVLEHEMEI-QGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGR 850
S ++ EM + + L+ + E+ + L Q L + EL+A R
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 851 DSLMSQAPISNQQAEVTPTGCLGKQTDQGSM--QIPSRDDSTSLTAKEDVSIPRSTLGDL 908
L+ Q Q E+ L ++ + + + SR + ++ R+ DL
Sbjct: 1060 SRLVKQMEDKVSQLEME----LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDL 1115
Query: 909 D-TVAGLEKELSNAKEELELMAKKERESQMELSA-LQSMMAVQEEELQVQAADMESLTRN 966
+ LE++ + K + + R S+ L +++ +A E+ L+ + D +L +
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLS 1175
Query: 967 IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 1026
+ E +K+L MQ VD E + ++ Q L L+ VE +EI +R + L
Sbjct: 1176 NRRLERKVKELVMQ-VDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI--DRLESSKKKL 1232
Query: 1027 EGLVDERSRLNEALQAE 1043
+ ++E+ +NE LQ +
Sbjct: 1233 QRELEEQMDMNEHLQGQ 1249
Score = 51.2 bits (121), Expect = 5e-06
Identities = 72/339 (21%), Positives = 149/339 (43%), Gaps = 41/339 (12%)
Query: 385 QKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 444
+KL I + S + + ELQ ++ + + N+ +L EM +LK ++K
Sbjct: 951 EKLQKEMADIVEASRTST--LELQNQLDEYKEKNR---RELAEMQRQLKEKTLEAEKSRL 1005
Query: 445 TIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVAL 504
T +++ ++ E EEL Q++ + K R++L Q+ + E S + +
Sbjct: 1006 TAMKMQDEMRLME---EELRDYQRAQDEALTK-RQLLEQTLKDLEYELEAKSHLKDDRSR 1061
Query: 505 LDLQSALFCSQLEIQK----------LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 554
L Q SQLE++ +R+ R +E+ + +Q AA + E K
Sbjct: 1062 LVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ-ERAARQDLECDKI 1120
Query: 555 ASWKHNQELRKALQQLQEELQNKSQ----QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 610
+ + N++L+ + L+ ++ + Q+ A AE + + ++E++ +L S E
Sbjct: 1121 SLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLE 1180
Query: 611 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 670
+ ++E ++Q D + + L +L+ A++R + EE E+E+
Sbjct: 1181 RKVKEL--VMQVDDEHLSLTDQKDQLSLRLK--------AMKRQV-------EEAEEEID 1223
Query: 671 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGL 709
+L + ++ +LE D+ + + SM+ LR K L
Sbjct: 1224 RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKL 1262
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 101 bits (251), Expect = 5e-21
Identities = 156/692 (22%), Positives = 291/692 (42%), Gaps = 107/692 (15%)
Query: 445 TIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVAL 504
T+ + L R+ + +++ E D + LR+ L S+ SE + +Q L
Sbjct: 520 TLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE------SERRALEEQLQRL 573
Query: 505 LD----LQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 560
D A +Q E+Q+L+ R+ ++ +Q + A E Q++E
Sbjct: 574 RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQ 633
Query: 561 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 620
+ELR+ +L+EE ++ Q A E+ + ++ L S + L E RE L
Sbjct: 634 EELRRQRDRLEEEQEDAVQD----GARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL 689
Query: 621 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE---KFSALEEKEKELRQLRLAVR 677
L+A + + + + V LE ++ + + ++L++ +L L ++
Sbjct: 690 SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLA 749
Query: 678 ERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEE--METKFSRW 735
+ DL RL A ++ +S L+ + + EQ +T + Q EE +E + +R
Sbjct: 750 QDKLDLNRL-------VAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
Query: 736 ---------QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRK 786
++ QE++ QQL T H+R++ E L+ L + G+ + E+ + QR+
Sbjct: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ--LSRQLSGREQELEQARREAQRQ 860
Query: 787 ERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQY 846
L+ ++ EH GL + E+E + +E+ + +E+ +AL
Sbjct: 861 VEALERAAREKEALAKEH----AGLAVQLVAAEREGRTLSEEATRLRLEK----EALEGS 912
Query: 847 LGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG 906
L ++Q +Q E + L AKE ++ G
Sbjct: 913 LFEVQRQLAQLEARREQLEA--------------------EGQALLLAKETLT------G 946
Query: 907 DLDTVAGLEKELSNAKE----ELELMAKK----ERESQMELSALQSMMAVQEEELQVQAA 958
+L AGL +++ +E + ELMA+K ERE+Q ++L+ A EE+LQ
Sbjct: 947 EL---AGLRQQIIATQEKASLDKELMAQKLVQAEREAQ---ASLREQRAAHEEDLQRLQR 1000
Query: 959 DMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE---IS 1015
+ E+ R ++ + LQ QL E + RL E L E++A+++ + E ++
Sbjct: 1001 EKEAAWRELEAER---AQLQSQL-QREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
Query: 1016 GNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 1075
+ +QQ L + E E++ L+E L R SL E +RD + E + + V
Sbjct: 1057 ESEKQQALSLKE---SEKTALSEKLMGTRH---SLATISLEMERQKRDAQSRQEQDRSTV 1110
Query: 1076 ---------LRSRLEEVLGRSLERLNRLETLA 1098
LR++ EE + + RL+ A
Sbjct: 1111 NALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
Score = 90.5 bits (223), Expect = 8e-18
Identities = 209/936 (22%), Positives = 367/936 (39%), Gaps = 112/936 (11%)
Query: 230 GESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGKCDCCSDDQ--APQHGCNHK 287
G + S+ L SPP++ RS + G CSD A H HK
Sbjct: 472 GSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR-GPSPACSDSSTLALIHSALHK 530
Query: 288 LELALSMIKGLDYKPIQSPRGS-RLPIPVKSSLPGAKPGP-----SMTDGVSSGFLN--- 338
+L + ++G Y+ Q G+ R + S A TDG +
Sbjct: 531 RQLQVQDMRGR-YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
Query: 339 -----RSLKPLY---KTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQ-KLNS 389
RS L K+ +++ L+++ Q ++L ++ L Q EEL +Q+ +L
Sbjct: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQA--EELRQEREKL--QAAQEELRRQRDRLEE 645
Query: 390 HETTITQQSVS-DSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN 448
+ Q L +++Q E +L ++L E+ L A
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 449 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSS--EGTSPAQQQVALLD 506
+ E L E EL + A L++ L S+L L+ S + + VA L+
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSL--SKLSALNESLAQDKLDLNRLVAQLE 763
Query: 507 LQ-SALFCSQLEIQKLQRVVRQKERQLADAKQ----CVQFVEAAAHESEQQKEASWKHNQ 561
+ SAL Q + ++ V R+++ +L + + Q +E + +EQ +EA +
Sbjct: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
Query: 562 ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-- 619
LR QLQE+L S+QL E E R ++ ++ L + KE L +E L
Sbjct: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAV 883
Query: 620 -LQYRDNSDKTL--EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 676
L + +TL EA + LEK + + ++R + + + E+ E E + L LA
Sbjct: 884 QLVAAEREGRTLSEEATRLRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK 941
Query: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736
+L LR + + + + L+ K ++ E+ + +L+ + E R Q
Sbjct: 942 ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA--SLREQRAAHEEDLQRLQ 999
Query: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
+E+E+ ++L+ +++ LL +L + E++EE+ Q ++ L LL++
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGL--LLAE 1057
Query: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKL---------VQALMER-----NSELQA 842
KQ Q++S +E E A +EKL + MER S +
Sbjct: 1058 SEKQ------------QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 843 LRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPR 902
R + S + ++A + + +Q RD + L E++
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD--SCLREAEELRTQL 1163
Query: 903 STLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMES 962
L D GL +EL A+ +L RESQ + L A + E+
Sbjct: 1164 RLLEDARD--GLRRELLEAQRKL-------RESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 963 LTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQG-------QEIS 1015
L R+ + +K + + + + A E Q++ LL E +V + QE+
Sbjct: 1215 LRRSNEELRSAVKKAESERISLK--LANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272
Query: 1016 GNR------RQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSER------- 1062
+R Q+L ++ L E +RL L AE Q +L + A ES
Sbjct: 1273 RSRLEARRELQELRRQMKMLDSENTRLGREL-AELQGRLALGE-RAEKESRRETLGLRQR 1330
Query: 1063 ----DRTLQVELEGAQVLRSRLEEVLGRSLERLNRL 1094
+ +L+V + QV + +L+E G R RL
Sbjct: 1331 LLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
Score = 87.4 bits (215), Expect = 7e-17
Identities = 154/661 (23%), Positives = 281/661 (42%), Gaps = 75/661 (11%)
Query: 382 LKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQK 441
L KL + E ++ S S L+ L E + Q + L +L E L+ Q +++
Sbjct: 722 LSMTKLRAEEASLQD---SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 778
Query: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQ 501
+ + +E L+ E E Q +EG + +E L Q QL L S Q+Q
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ-QLPTLRHER--SQLQEQ 835
Query: 502 VALL---------DLQSALFCSQLEIQKLQRVVRQKERQLAD-AKQCVQFVEAAAHESEQ 551
+A L +L+ A +Q +++ L+R R+KE + A VQ V A
Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 552 QKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQ 611
+EA+ LR + L+ L +QL EA + ++ + Q + +L+ +
Sbjct: 896 SEEAT-----RLRLEKEALEGSLFEVQRQLAQLEARR-EQLEAEGQALLLAKETLTGELA 949
Query: 612 LLQEFRELLQYRDNSDKTLEANEMLLEK------LRQRIHDKAVALERAIDEKFSALEEK 665
L++ Q + + DK L A +++ + LR++ L+R EK +A E
Sbjct: 950 GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 666 EKELRQLRLAV-RERDHDLERL---RDVLSSNEATMQSM--ESLLRAKGLEVEQLST--- 716
E E QL+ + RE++ L RL ++ LS A +Q E LL A+ + + LS
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKES 1069
Query: 717 -----------TCQNLQWLKEEMETKFSRWQKEQE---SIIQQLQTSLHDRNKEVEDLSA 762
T +L + EME + Q QE S + L + L D + E+ +A
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAA 1129
Query: 763 TLLCKLGPGQSEIAE-----ELCQR----LQRKERMLQDLLSDRNKQVLEHEMEIQGLLQ 813
++ Q + + + C R L+ + R+L+D +++LE + +++ +
Sbjct: 1130 AHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---E 1186
Query: 814 SVSTREQESQAAAE---------KLVQALMERNSELQ-ALRQYLGGRDSLMSQAPISNQQ 863
S RE + Q A E K +AL N EL+ A+++ R SL Q+
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
Query: 864 AEVTPTGCLGKQTDQGSMQIPSRD-DSTSLTAKEDVSIPRSTLGDLDTV-AGLEKELSNA 921
+ + G ++ ++ + + L A+ ++ R + LD+ L +EL+
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
Query: 922 KEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQL 981
+ L L + E+ES+ E L+ + E L+V +++ R +Q +E + + +L
Sbjct: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
Query: 982 V 982
+
Sbjct: 1367 L 1367
Score = 71.6 bits (174), Expect = 4e-12
Identities = 166/749 (22%), Positives = 284/749 (37%), Gaps = 169/749 (22%)
Query: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR--VQPMTEE---LLKQQKLNSHE 391
L S+ L S LS L L + L +D L L V + EE L +Q+ E
Sbjct: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
Query: 392 TTIT---QQSVSDSHLAE------LQEKIQQTEATNKILQEKLNEMSYELKCAQES---- 438
T+ Q+ + + L + L+ ++ E + L+++L + +E QE
Sbjct: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 439 SQKQDGTIQNLKETLKSRERETEELYQVI----------------------EGQ--NDTM 474
S++ G Q L++ + +R+ E L + EG+ ++
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 475 AKLR---EMLH------QSQLGQLHSSEGTSPAQQQVALL----------DLQSALFCSQ 515
+LR E L Q QL QL + A+ Q LL L+ + +Q
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 959
Query: 516 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQ-----KEASWKHNQ----ELRKA 566
+ + ++ QK Q Q + AAHE + Q KEA+W+ + +L+
Sbjct: 960 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQ 1019
Query: 567 LQQLQEEL-------------------QNKSQQLRAWEAEKYNEIRTQE-------QNIQ 600
LQ+ QEEL Q + + L E+EK + +E + +
Sbjct: 1020 LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 601 HLNHSLSHKEQLLQEFRELLQYRDNSDK-TLEANEMLLEKLRQRIHDKAVA--------L 651
HSL+ ++ + Q R D+ T+ A L LR + + A A
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
Query: 652 ERAID---EKFSALEEKEKELRQLRLAVRERD-------HDLERLRDVLSSNEATMQSME 701
E+A D ++ S L E E+ QLRL RD +LR+ E Q
Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
Query: 702 SLLRAKGLEVEQLSTTCQNLQWLK--------EEMETKFSRWQKEQE-SIIQQLQTSLHD 752
L R+ G ++ ++ + L+ E + K + KEQ+ +++++ +T++
Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV-- 1257
Query: 753 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 812
KE +L T L ++ + E EL Q L+R+ +ML N ++ E+QG L
Sbjct: 1258 -GKEAGELR-TGLQEVERSRLEARREL-QELRRQMKMLDS----ENTRLGRELAELQGRL 1310
Query: 813 QSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 872
E+ES+ L Q L++ + L+ +RQ L ++Q + Q+ E
Sbjct: 1311 ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQ-----VAQRKLQEQEGEFRTR--- 1362
Query: 873 GKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKE 932
R LG L+ G EK+ + LEL +
Sbjct: 1363 ----------------------------ERRLLGSLEEARGTEKQQLDHARGLELKLEAA 1394
Query: 933 RESQMELSALQSMMAVQEEELQVQAADME 961
R EL S + + L+ + A +E
Sbjct: 1395 RAEAAELGLRLSAAEGRAQGLEAELARVE 1423
Score = 67.4 bits (163), Expect = 7e-11
Identities = 170/771 (22%), Positives = 317/771 (41%), Gaps = 119/771 (15%)
Query: 364 DLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQE 423
DL +D + + E++ + L+ E+ + + + L LQE+ N++LQ+
Sbjct: 37 DLAQDAQITSLPALIREIVTRN-LSQPESPVLLPATEMASLLSLQEE-------NQLLQQ 88
Query: 424 KLNEMSYELKCAQ----ESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLRE 479
+L+ + L ++ E + K + + L++ L+ E E Q G +LR
Sbjct: 89 ELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET--QEPRGLVRQSVELRR 146
Query: 480 MLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCV 539
L + Q + QQ+ A L +Q+LQ + Q +++ ++ +Q
Sbjct: 147 QLQEEQASYRRKLQAYQEGQQRQAQL------------VQRLQGKILQYKKRCSELEQ-- 192
Query: 540 QFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQ--QLRAWEAEKYNEIRTQEQ 597
Q +E + E EQQ+ +H+Q+L AL +L+EE Q + Q+ A E+ ++ + Q
Sbjct: 193 QLLERSG-ELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQ 251
Query: 598 ----NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANE--MLLEKLRQRIHDKAVAL 651
+I+ + + + + L+ + + S +NE LL RQ + + +
Sbjct: 252 ALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVS 311
Query: 652 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLER-LRDVLSSNEATMQSMESLLRAKGLE 710
E + + L + EL + AV+E L LR S EA ++ ++LL+A+
Sbjct: 312 EVKMFTERDLL-QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEK-QALLQAQ--- 366
Query: 711 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGP 770
L+E++ K R E++ QQ+Q+ L + DLSA +
Sbjct: 367 -------------LEEQLRDKVLR---EKDLAQQQMQSDL-----DKADLSARV------ 399
Query: 771 GQSEIAEELCQRLQRKERMLQDLLSDR-NKQVLEHEMEIQGL-LQSVSTREQES----QA 824
EL ++R E+ Q+L D+ NK + E ++ L LQ + E E Q
Sbjct: 400 ------TELGLAVKRLEK--QNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ 451
Query: 825 AAEKLVQALMERNSELQALRQYLGG-RDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 883
L QA++ S+ ++ Q G R + S + + TP+ +++ G +
Sbjct: 452 TLRDLAQAVL---SDSESGVQLSGSERTADASNGSLRGLSGQRTPSP--PRRSSPGRGRS 506
Query: 884 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 943
P R P D T+A + L + +++ M + SQ L L+
Sbjct: 507 PRRG-------------PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553
Query: 944 SMMAVQEEELQVQAADMESLTRN----IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLL 999
++ E E + ++ L +Q ED +++Q A E L++E
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLR------SANELLSREKSN 607
Query: 1000 LREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNE----ALQAERQLYSSLVKFHA 1055
L + + Q +E+ R++L E L +R RL E A+Q ++ L + H
Sbjct: 608 LAHSLQVAQQQAEELR-QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR 666
Query: 1056 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAG 1106
E E R++ + E +V + L R + + + E A+ A AG
Sbjct: 667 QLEQLEGKRSVLAK-ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAG 716
Score = 61.2 bits (147), Expect = 5e-09
Identities = 94/470 (20%), Positives = 198/470 (42%), Gaps = 68/470 (14%)
Query: 561 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 620
QELR A Q+ ++EL+ ++ L AE E + + L +++ E+ + L
Sbjct: 1516 QELRSA-QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 621 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 680
E + E+ R+ D+ LER++ S L ++++ +++ + +
Sbjct: 1575 SGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLE 1634
Query: 681 HDLERLRDVLSSNEATMQSMESLLRA--------------KGLEVEQLSTTCQNLQWLKE 726
D RL++VL ++E+ +E R+ + + + L +LQ
Sbjct: 1635 GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694
Query: 727 EMETKFSRWQKEQESI------IQQLQTSLHD-------------------RNKEVEDLS 761
+ E K Q E + +++ + +L D R+K +
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754
Query: 762 ATLLC---------KLGPGQSEIAEELCQ--RLQRKERMLQDLLSDRNKQVLEHEMEIQG 810
A C +L + ++E Q L + + L+ ++D Q +E E ++Q
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ- 1813
Query: 811 LLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG 870
L+ V + QE +AAA VQ L + E + L++ LG ++Q ++ E
Sbjct: 1814 QLREVLRQRQEGEAAALNTVQKLQD---ERRLLQERLGSLQRALAQLEAEKREVE---RS 1867
Query: 871 CLGKQTDQGSM-QIPSRDDSTSLTAKEDVSIPRSTLGDLD-TVAGLEKELSNAKEELE-- 926
L + D+ ++ + + + L + ED + G LD T+ G E EL+ A+ +++
Sbjct: 1868 ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
Query: 927 -----LMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKE 971
++ + +Q+E+ A Q + +Q+E ++++A ++ R ++ +E
Sbjct: 1928 EAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQT-ERTLEARE 1976
Score = 59.7 bits (143), Expect = 2e-08
Identities = 121/585 (20%), Positives = 226/585 (38%), Gaps = 105/585 (17%)
Query: 310 RLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSL---KPLYKTPVSYPLELSDLQELWDDLC 366
R P P +PG+ + +G G + S P + P P +L +
Sbjct: 1448 RAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAV 1507
Query: 367 EDYLPLRVQPMTEELLKQQKLNSHETTITQQSV--------SDSHLAELQEKIQQTEATN 418
L +Q + ++ +L + + + +Q + S +LQ+ + ++E
Sbjct: 1508 RGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEAR 1567
Query: 419 KILQEKLNEMSYELKCAQESSQK----------QDGTIQNLKETLKSRERETEE------ 462
+ + +L+ + EL +ES ++ Q T++ + +S R ++E
Sbjct: 1568 RSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627
Query: 463 ------------LYQVIEGQNDTMAKLREMLHQSQLGQLHSSE-GTSPAQQQVALL---- 505
L +V++ KL E+ +S G+L S G S + Q L
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKL-ELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
Query: 506 -DLQSALFCSQLEIQKLQRVVRQKERQLADAKQC-------VQFVEAAAHESEQQKEASW 557
LQ + S+++ LQ V + LA ++ V+ + A +S ++
Sbjct: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746
Query: 558 KHNQELRKAL-------QQLQEELQNKSQQL---RAWEAEKYNEIRTQEQNIQHLNHSLS 607
N L+KAL Q LQE L Q L R + +++T + L
Sbjct: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRV 1806
Query: 608 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEK 667
E LQ+ RE+L+ R + L+ R+ + ++ +L+RA+ + + E E+
Sbjct: 1807 EAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVER 1866
Query: 668 ELRQL---RLAVRERDHDLERLRDVLSSNEATMQ------SMESLLRAKGLEVEQLSTTC 718
+L R+A+R +E R+ L S+E T++ ++ L LE+ +
Sbjct: 1867 SALRLEKDRVALRRTLDKVE--REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
Query: 719 QNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEE 778
Q L+ +E S Q E ++ QQL+ +EVE L + Q+E
Sbjct: 1925 QQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-----QQEVERL------RSAQAQTE---- 1969
Query: 779 LCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 823
+ L+ +ER H ++GL + VST + + Q
Sbjct: 1970 --RTLEARER--------------AHRQRVRGLEEQVSTLKGQLQ 1998
Score = 38.1 bits (87), Expect = 0.048
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 26/137 (18%)
Query: 378 TEELLKQQKLNSHETTITQQSV----------SDSHLAELQEKIQQTEATNKILQEKLNE 427
T + ++++KL SHE T+ + ++ LAE Q +IQQ EA +L++ +
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940
Query: 428 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLG 487
E+ +Q+Q +Q E L+S + +TE + RE H+ ++
Sbjct: 1941 AQLEV-----DAQQQQLELQQEVERLRSAQAQTERTLEA-----------RERAHRQRVR 1984
Query: 488 QLHSSEGTSPAQQQVAL 504
L T Q Q L
Sbjct: 1985 GLEEQVSTLKGQLQQEL 2001
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 101 bits (251), Expect = 5e-21
Identities = 176/861 (20%), Positives = 339/861 (39%), Gaps = 142/861 (16%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYEL 432
R+ +T L ++++ + T + + +S ++EL+ ++++ E + + L++ ++ +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 433 KCAQESSQKQDGTIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLG 487
E I LK L +E E + L I +N+ + K+RE+ H S L
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 488 QLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQF 541
+ SE + + + DL L + E++ Q+ +R K Q +
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 542 VEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQ 595
E +HE++ Q E KH Q + + +QL++ L Q L A+ E+R
Sbjct: 1185 EETRSHEAQVQ-EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 596 EQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD--------- 646
Q Q + H E +QE + + D E N+ + KL+ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAE 1300
Query: 647 -KAVALERAIDEKFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQ 698
KA+ L + + S L++ ++ L++ + +R+ + + L+D L Q
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 699 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQT 748
++E + +++ Q+ E +E R+QKE E++ QQ L+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 749 SLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI 808
+ + +E++DL L + +L L++K+R LL++ ++ E
Sbjct: 1421 TKNRLQQELDDLVVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 809 QGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEV 866
+E ++ + A L +AL E EL+ + L D + S+ + E+
Sbjct: 1472 DRAEAEAREKETKALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 867 TPT-GCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIP------------------------ 901
+ L Q ++ Q+ +D L A ED +
Sbjct: 1531 EKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 902 ------RSTLGDLDT-----------VAGLEKELSNAKEELELMA----KKERESQMELS 940
+ L + +T A +K+L ++LEL A K E+ +L
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 941 ALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLL 999
LQ+ M + EL+ A + + + E K L+ L+ ED+ A ER ++ L
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 1000 LREKVASVESQGQEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAE 1043
+E++A E +SG R + + LE ++E R+ +A Q
Sbjct: 1709 EKEELA--EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 1044 RQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGA 1103
QL + L + + +E R Q+E + + LRS+L E+ G + T+AA+
Sbjct: 1767 EQLSNELATERSTAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL--- 1819
Query: 1104 AAGDDTEDTSTEFTDSIEEEA 1124
E + + +E+EA
Sbjct: 1820 ------EAKIAQLEEQVEQEA 1834
Score = 100 bits (250), Expect = 6e-21
Identities = 170/771 (22%), Positives = 331/771 (42%), Gaps = 127/771 (16%)
Query: 366 CEDYLPLR----------VQPMTEELLKQQKLNSHET----TITQQSVSDSHLAELQEKI 411
C YL LR V+P+ + +++++ + E T +Q +++ L EL++K
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 412 QQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQN 471
Q +LQE+L ++ + + ++ L ++++E EE+ +E
Sbjct: 883 SQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAAKKQELEEILHEME--- 928
Query: 472 DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ 531
A+L E + GQ +E AQQ +LDL+ QLE ++ R Q E+
Sbjct: 929 ---ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQLEEEEAARQKLQLEKV 974
Query: 532 LADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNE 591
A+AK ++ +E + Q N +L K + L+E + + + L
Sbjct: 975 TAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERISDLTTNL---------- 1015
Query: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVAL 651
+E+ ++L + E ++ E L+ + S + LE + LE H++ L
Sbjct: 1016 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 652 ERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK 707
+ I E L +KE+EL+ +L + ++++ L+++R++ + ++S A+
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 708 GLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESIIQQLQTSLHDRNKEVED 759
+Q + L+ LK E+E R ++EQE + + R+ E +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ- 1193
Query: 760 LSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHE-MEIQGLLQSVSTR 818
+ ++ ++ EEL ++L++ +R +L D+NKQ LE E ++ G L+ +
Sbjct: 1194 -----VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLEKENADLAGELRVLGQA 1246
Query: 819 EQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEV-TPTGCLGK 874
+QE + +KL VQ L + S+ + R L + + Q EV + TG L +
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------VHKLQNEVESVTGMLNE 1298
Query: 875 QTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 931
+ + + S T + R L + LE+E ++ +++L+ +
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 932 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 991
++ + +S L ++ +++LQ A+ +E+L E+ K Q ++ E
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEI---------E 1402
Query: 992 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLV 1051
LTQ+ EK A+ + E + NR QQ L L +D + +L L+ +++ + L+
Sbjct: 1403 NLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 1052 KFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRSLERLNRL 1094
+ S D + E E A L LEE L LER N++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Score = 95.5 bits (236), Expect = 3e-19
Identities = 137/711 (19%), Positives = 288/711 (40%), Gaps = 116/711 (16%)
Query: 401 DSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERET 460
++ + ELQ K E L +K++++ E++ + +G L + + S +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 461 EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK 520
++ +++ Q +T KL QL + +S LQ L Q
Sbjct: 1318 QDTQELL--QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQN 1361
Query: 521 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEE------L 574
L+R + QL+D+K+ +Q + E+ K+ + +E+ QQ +E+ L
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKL 1418
Query: 575 QNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL-QYRDNSDKT-LEA 632
+ +L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 633 NEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS 692
E KA++L RA++E A EE E+ + L+ + DL +D +
Sbjct: 1479 REK---------ETKALSLARALEEALEAKEELERTNKMLKAEME----DLVSSKDDVGK 1525
Query: 693 N----EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQK 737
N E + +++E+ + ++E+L Q N+Q LK + E +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 738 EQESIIQQLQTSLHDRNKEVED------LSATLLCKLGPGQSEIAEELCQRLQRKERMLQ 791
+ E +QLQ LH+ E+ED L+A KL ++ + ++ +E ++
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 792 DLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRD 851
L +++ + Q L+ E A A++ + ++L L++ L +
Sbjct: 1646 QL-----RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 852 SLMSQAPISNQQ-AEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
QA + ++ AE + G+ Q + R ++ +E++ + G+++
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKR---RLEARIAQLEEELEEEQ---GNMEA 1754
Query: 911 VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME--------- 961
++ ++ + E+L ER + + + + + Q +EL+ + +ME
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 962 ------------------------SLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ER 992
+ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 993 LTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 1043
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1920
Score = 58.5 bits (140), Expect = 3e-08
Identities = 88/438 (20%), Positives = 187/438 (42%), Gaps = 61/438 (13%)
Query: 379 EELLKQQKLNSHETTITQQSVSD--SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQ 436
EEL + K+ E S D ++ EL++ + E + ++ +L E+ EL+ +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 437 ESSQKQDGTIQNLK----ETLKSRERETEELYQVIEGQ-NDTMAKLREMLHQSQLG---- 487
++ + + +Q LK L++R+ + EE + ++ Q ++ +L + Q L
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 488 -QLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 546
+L Q A+ + A+ +++KLQ ++ +R+L DA+ + A A
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 547 HESEQQKEASWKHNQELRKAL--------------QQLQEEL----------QNKSQQLR 582
E+E++ ++ +L++ L ++L EEL Q++ ++L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 583 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLR 641
A A+ E+ ++ N++ ++ + Q ++ EL R + K A + L E+
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQN 1794
Query: 642 QRIHDKAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDV 689
+ + K +E A+ KF +ALE K E+E R+ + A + ++L+++
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 690 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTS 749
L E + E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1855 LLQVEDERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 750 LHDR---NKEVEDLSATL 764
+EV L + L
Sbjct: 1911 TESNEAMGREVNALKSKL 1928
Score = 55.1 bits (131), Expect = 4e-07
Identities = 59/301 (19%), Positives = 130/301 (43%), Gaps = 14/301 (4%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSYELKCAQ 436
EE +KQ + + Q+ + D+ + E+ ++ E K L+ L ++ +L A+
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 437 ESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTS 496
+ ++ D + L E L S L +A+L E L + Q S+
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 497 PAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 556
A QQ L + L + QK + +Q ERQ + + + +E A + A+
Sbjct: 1761 KATQQAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 557 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 616
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ +++
Sbjct: 1819 ------LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 617 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 676
+E + + K L+ E+ QRI+ L+R +DE + E +E+ L+ +
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 677 R 677
R
Sbjct: 1929 R 1929
Score = 40.4 bits (93), Expect = 0.010
Identities = 40/247 (16%), Positives = 109/247 (44%), Gaps = 23/247 (9%)
Query: 356 SDLQELWDDLCEDYLPLRVQPMTEELLKQQ---KLNSHETTITQQSVSDSHLAELQEKIQ 412
+DL +L +DL + + +E L ++ L+ ++ ++ +A+L+E+++
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 413 QTEATNKILQEKLN-------EMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 465
+ + + + +++ ++S EL + ++QK + Q L+ K + E+
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 466 VIEGQ-NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE------- 517
++ + T+A L + Q + + A + + D + Q+E
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1866
Query: 518 -----IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 572
+K V+Q +RQL +A++ Q + A + +++ + + + N+ + + + L+
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 573 ELQNKSQ 579
+L+ ++
Sbjct: 1927 KLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 101 bits (251), Expect = 5e-21
Identities = 176/861 (20%), Positives = 339/861 (39%), Gaps = 142/861 (16%)
Query: 373 RVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYEL 432
R+ +T L ++++ + T + + +S ++EL+ ++++ E + + L++ ++ +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 433 KCAQESSQKQDGTIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLG 487
E I LK L +E E + L I +N+ + K+RE+ H S L
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 488 QLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQF 541
+ SE + + + DL L + E++ Q+ +R K Q +
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 542 VEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQ 595
E +HE++ Q E KH Q + + +QL++ L Q L A+ E+R
Sbjct: 1192 EETRSHEAQVQ-EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 596 EQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD--------- 646
Q Q + H E +QE + + D E N+ + KL+ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAE 1307
Query: 647 -KAVALERAIDEKFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQ 698
KA+ L + + S L++ ++ L++ + +R+ + + L+D L Q
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 699 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQT 748
++E + +++ Q+ E +E R+QKE E++ QQ L+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 749 SLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI 808
+ + +E++DL L + +L L++K+R LL++ ++ E
Sbjct: 1428 TKNRLQQELDDLVVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 809 QGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEV 866
+E ++ + A L +AL E EL+ + L D + S+ + E+
Sbjct: 1479 DRAEAEAREKETKALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 867 TPT-GCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIP------------------------ 901
+ L Q ++ Q+ +D L A ED +
Sbjct: 1538 EKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 902 ------RSTLGDLDT-----------VAGLEKELSNAKEELELMA----KKERESQMELS 940
+ L + +T A +K+L ++LEL A K E+ +L
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 941 ALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVD-PEDIPAMERLTQEVLL 999
LQ+ M + EL+ A + + + E K L+ L+ ED+ A ER ++ L
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 1000 LREKVASVESQGQEISG--------NRRQQLLLMLEGLVDER--------SRLNEALQAE 1043
+E++A E +SG R + + LE ++E R+ +A Q
Sbjct: 1716 EKEELA--EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 1044 RQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGA 1103
QL + L + + +E R Q+E + + LRS+L E+ G + T+AA+
Sbjct: 1774 EQLSNELATERSTAQKNESARQ-QLERQNKE-LRSKLHEMEGAVKSKFK--STIAAL--- 1826
Query: 1104 AAGDDTEDTSTEFTDSIEEEA 1124
E + + +E+EA
Sbjct: 1827 ------EAKIAQLEEQVEQEA 1841
Score = 100 bits (250), Expect = 6e-21
Identities = 170/771 (22%), Positives = 331/771 (42%), Gaps = 127/771 (16%)
Query: 366 CEDYLPLR----------VQPMTEELLKQQKLNSHET----TITQQSVSDSHLAELQEKI 411
C YL LR V+P+ + +++++ + E T +Q +++ L EL++K
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 412 QQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQN 471
Q +LQE+L ++ + + ++ L ++++E EE+ +E
Sbjct: 890 SQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAAKKQELEEILHEME--- 935
Query: 472 DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ 531
A+L E + GQ +E AQQ +LDL+ QLE ++ R Q E+
Sbjct: 936 ---ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQLEEEEAARQKLQLEKV 981
Query: 532 LADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNE 591
A+AK ++ +E + Q N +L K + L+E + + + L
Sbjct: 982 TAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERISDLTTNL---------- 1022
Query: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVAL 651
+E+ ++L + E ++ E L+ + S + LE + LE H++ L
Sbjct: 1023 -AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 652 ERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK 707
+ I E L +KE+EL+ +L + ++++ L+++R++ + ++S A+
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 708 GLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESIIQQLQTSLHDRNKEVED 759
+Q + L+ LK E+E R ++EQE + + R+ E +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ- 1200
Query: 760 LSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHE-MEIQGLLQSVSTR 818
+ ++ ++ EEL ++L++ +R +L D+NKQ LE E ++ G L+ +
Sbjct: 1201 -----VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLEKENADLAGELRVLGQA 1253
Query: 819 EQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEV-TPTGCLGK 874
+QE + +KL VQ L + S+ + R L + + Q EV + TG L +
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------VHKLQNEVESVTGMLNE 1305
Query: 875 QTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKK 931
+ + + S T + R L + LE+E ++ +++L+ +
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 932 ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAME 991
++ + +S L ++ +++LQ A+ +E+L E+ K Q ++ E
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEI---------E 1409
Query: 992 RLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLV 1051
LTQ+ EK A+ + E + NR QQ L L +D + +L L+ +++ + L+
Sbjct: 1410 NLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 1052 KFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRSLERLNRL 1094
+ S D + E E A L LEE L LER N++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Score = 95.5 bits (236), Expect = 3e-19
Identities = 137/711 (19%), Positives = 288/711 (40%), Gaps = 116/711 (16%)
Query: 401 DSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERET 460
++ + ELQ K E L +K++++ E++ + +G L + + S +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 461 EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK 520
++ +++ Q +T KL QL + +S LQ L Q
Sbjct: 1325 QDTQELL--QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQN 1368
Query: 521 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEE------L 574
L+R + QL+D+K+ +Q + E+ K+ + +E+ QQ +E+ L
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKL 1425
Query: 575 QNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL-QYRDNSDKT-LEA 632
+ +L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 633 NEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSS 692
E KA++L RA++E A EE E+ + L+ + DL +D +
Sbjct: 1486 REK---------ETKALSLARALEEALEAKEELERTNKMLKAEME----DLVSSKDDVGK 1532
Query: 693 N----EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQK 737
N E + +++E+ + ++E+L Q N+Q LK + E +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 738 EQESIIQQLQTSLHDRNKEVED------LSATLLCKLGPGQSEIAEELCQRLQRKERMLQ 791
+ E +QLQ LH+ E+ED L+A KL ++ + ++ +E ++
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 792 DLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRD 851
L +++ + Q L+ E A A++ + ++L L++ L +
Sbjct: 1653 QL-----RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 852 SLMSQAPISNQQ-AEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDT 910
QA + ++ AE + G+ Q + R ++ +E++ + G+++
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKR---RLEARIAQLEEELEEEQ---GNMEA 1761
Query: 911 VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME--------- 961
++ ++ + E+L ER + + + + + Q +EL+ + +ME
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 962 ------------------------SLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ER 992
+ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 993 LTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 1043
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1927
Score = 58.5 bits (140), Expect = 3e-08
Identities = 88/438 (20%), Positives = 187/438 (42%), Gaps = 61/438 (13%)
Query: 379 EELLKQQKLNSHETTITQQSVSD--SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQ 436
EEL + K+ E S D ++ EL++ + E + ++ +L E+ EL+ +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 437 ESSQKQDGTIQNLK----ETLKSRERETEELYQVIEGQ-NDTMAKLREMLHQSQLG---- 487
++ + + +Q LK L++R+ + EE + ++ Q ++ +L + Q L
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 488 -QLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 546
+L Q A+ + A+ +++KLQ ++ +R+L DA+ + A A
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 547 HESEQQKEASWKHNQELRKAL--------------QQLQEEL----------QNKSQQLR 582
E+E++ ++ +L++ L ++L EEL Q++ ++L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 583 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRDNSDKTLEANEMLLEKLR 641
A A+ E+ ++ N++ ++ + Q ++ EL R + K A + L E+
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL-ERQN 1801
Query: 642 QRIHDKAVALERAIDEKF----SALEEK--------EKELRQLRLAVRERDHDLERLRDV 689
+ + K +E A+ KF +ALE K E+E R+ + A + ++L+++
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 690 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTS 749
L E + E + E+ + + L+ EE E + R + + ++L +
Sbjct: 1862 LLQVEDERKMAEQYKE----QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 750 LHDR---NKEVEDLSATL 764
+EV L + L
Sbjct: 1918 TESNEAMGREVNALKSKL 1935
Score = 55.1 bits (131), Expect = 4e-07
Identities = 59/301 (19%), Positives = 130/301 (43%), Gaps = 14/301 (4%)
Query: 379 EELLKQQKLNSHETTITQQSVSDSHLA--ELQEKIQQTEATNKILQEKLNEMSYELKCAQ 436
EE +KQ + + Q+ + D+ + E+ ++ E K L+ L ++ +L A+
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 437 ESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTS 496
+ ++ D + L E L S L +A+L E L + Q S+
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 497 PAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 556
A QQ L + L + QK + +Q ERQ + + + +E A + A+
Sbjct: 1768 KATQQAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 557 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 616
L + QL+E+++ ++++ +A ++ +++ ++ + + + ++ +++
Sbjct: 1826 ------LEAKIAQLEEQVEQEAREKQA----ATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 617 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 676
+E + + K L+ E+ QRI+ L+R +DE + E +E+ L+ +
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 677 R 677
R
Sbjct: 1936 R 1936
Score = 40.4 bits (93), Expect = 0.010
Identities = 40/247 (16%), Positives = 109/247 (44%), Gaps = 23/247 (9%)
Query: 356 SDLQELWDDLCEDYLPLRVQPMTEELLKQQ---KLNSHETTITQQSVSDSHLAELQEKIQ 412
+DL +L +DL + + +E L ++ L+ ++ ++ +A+L+E+++
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 413 QTEATNKILQEKLN-------EMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 465
+ + + + +++ ++S EL + ++QK + Q L+ K + E+
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 466 VIEGQ-NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE------- 517
++ + T+A L + Q + + A + + D + Q+E
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1873
Query: 518 -----IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 572
+K V+Q +RQL +A++ Q + A + +++ + + + N+ + + + L+
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 573 ELQNKSQ 579
+L+ ++
Sbjct: 1934 KLRRGNE 1940
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,249,711
Number of Sequences: 37866
Number of extensions: 1943693
Number of successful extensions: 21078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 364
Number of HSP's successfully gapped in prelim test: 1138
Number of HSP's that attempted gapping in prelim test: 9483
Number of HSP's gapped (non-prelim): 5603
length of query: 1132
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1019
effective length of database: 13,968,660
effective search space: 14234064540
effective search space used: 14234064540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.