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Search of human proteins with 5031699
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031699 flotillin 1 [Homo sapiens]
(427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031699 flotillin 1 [Homo sapiens] 809 0.0
gi|94538362 flotillin 2 [Homo sapiens] 379 e-105
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 8e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 8e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 8e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 62 8e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 62 8e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 62 8e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 62 8e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 62 8e-10
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 60 5e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 60 5e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 56 7e-08
gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens] 55 2e-07
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 54 2e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 54 3e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 54 4e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 53 5e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 53 5e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 53 5e-07
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 53 6e-07
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 53 6e-07
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 53 6e-07
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 53 6e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 52 8e-07
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 50 3e-06
gi|38016911 stomatin isoform a [Homo sapiens] 50 4e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 49 1e-05
gi|221316744 stomatin-like 3 isoform 2 [Homo sapiens] 48 1e-05
gi|21686995 stomatin-like 3 isoform 1 [Homo sapiens] 48 1e-05
>gi|5031699 flotillin 1 [Homo sapiens]
Length = 427
Score = 809 bits (2090), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG 60
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
Sbjct: 1 MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG 60
Query: 61 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI 120
VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
Sbjct: 61 VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI 120
Query: 121 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE 180
YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
Sbjct: 121 YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE 180
Query: 181 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL 240
AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
Sbjct: 181 AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL 240
Query: 241 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA 300
QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
Sbjct: 241 QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA 300
Query: 301 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK 360
EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
Sbjct: 301 EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK 360
Query: 361 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN 420
LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
Sbjct: 361 LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN 420
Query: 421 HKPLRTA 427
HKPLRTA
Sbjct: 421 HKPLRTA 427
>gi|94538362 flotillin 2 [Homo sapiens]
Length = 428
Score = 379 bits (973), Expect = e-105
Identities = 199/418 (47%), Positives = 299/418 (71%), Gaps = 8/418 (1%)
Query: 4 TCGPNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGV 61
T GPNEA+VVSG C V GG + CI QRISL +TL + E V T GV
Sbjct: 6 TVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGV 65
Query: 62 PISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIY 121
++VTG+AQVKI + KE+LA AC+ FLGK +I ++ L+TLEGH R+I+ +TVE+IY
Sbjct: 66 ALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIY 124
Query: 122 KDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEA 181
+DR +F++ V +VA+ D+ MGI ++S+T+KD++D DYL SLGK +TA VQ+DA IG A
Sbjct: 125 QDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVA 184
Query: 182 EAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQ 241
EA+RDAGIREA+ K+E + +++++ ++A ++R +EL+K+A+ EVN + A+A LAY+LQ
Sbjct: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
Query: 242 VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAE 301
A+ +Q+I ++ ++++VV+R +Q+AV+ QEI R +KEL A VR+PAEAE ++++++AE E
Sbjct: 245 GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
Query: 302 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKL 361
K + ++ A+AEA +R GEAEA I A +AEAE+M KAEA+Q Y +AA++ ++LE L
Sbjct: 305 KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEAL 364
Query: 362 PQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQV 419
PQ+A +I+ PLT ++I ++S + +KVT EV +L LP SV LTGV +S++
Sbjct: 365 PQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDLSKI 417
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2148
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1389 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1442
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1503 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1562 QVQVALETAQRSAE 1575
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1523
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1641
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1702 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1754
Query: 370 GPL 372
L
Sbjct: 1755 AEL 1757
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2180 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2418 HRTELATQEKVTLVQTLE 2435
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1770
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1771 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2498
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2499 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2609 LAHSEEVTASQVA 2621
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2446 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2505 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2555
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 387 TMGAAKVT 394
T T
Sbjct: 2616 TASQVAAT 2623
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1279
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1280 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2095
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2152
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1393 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1446
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1507 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1566 QVQVALETAQRSAE 1579
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1527
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1645
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1705
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1706 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1758
Query: 370 GPL 372
L
Sbjct: 1759 AEL 1761
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2184 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2422 HRTELATQEKVTLVQTLE 2439
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1774
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1775 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1931
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2384 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2443
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2444 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2502
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2503 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2613 LAHSEEVTASQVA 2625
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2450 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2509 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2559
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Query: 387 TMGAAKVT 394
T T
Sbjct: 2620 TASQVAAT 2627
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1283
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1284 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1340
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2148
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1389 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1442
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1503 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1562 QVQVALETAQRSAE 1575
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1523
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1641
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1702 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1754
Query: 370 GPL 372
L
Sbjct: 1755 AEL 1757
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2180 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2418 HRTELATQEKVTLVQTLE 2435
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1770
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1771 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2380 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2498
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2499 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2609 LAHSEEVTASQVA 2621
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2446 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2505 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2555
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 387 TMGAAKVT 394
T T
Sbjct: 2616 TASQVAAT 2623
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1279
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1280 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1336
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2059
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2116
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1357 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1410
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1471 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1530 QVQVALETAQRSAE 1543
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1491
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1609
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1669
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1670 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1722
Query: 370 GPL 372
L
Sbjct: 1723 AEL 1725
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2148 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2386 HRTELATQEKVTLVQTLE 2403
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1738
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1739 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1895
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2348 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2407
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2408 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2466
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2467 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2577 LAHSEEVTASQVA 2589
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2414 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2473 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2523
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 387 TMGAAKVT 394
T T
Sbjct: 2584 TASQVAAT 2591
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1247
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1248 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1304
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2228
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2285
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1526 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1579
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1640 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1699 QVQVALETAQRSAE 1712
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1660
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1778
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1838
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1839 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1891
Query: 370 GPL 372
L
Sbjct: 1892 AEL 1894
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2317 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2555 HRTELATQEKVTLVQTLE 2572
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1907
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1908 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 2064
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2517 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2576
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2577 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2635
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2636 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2746 LAHSEEVTASQVA 2758
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2583 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2642 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2692
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Query: 387 TMGAAKVT 394
T T
Sbjct: 2753 TASQVAAT 2760
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1416
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1417 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1473
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2069
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2126
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1367 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1420
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1481 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1540 QVQVALETAQRSAE 1553
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1501
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1619
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1679
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1680 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1732
Query: 370 GPL 372
L
Sbjct: 1733 AEL 1735
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2158 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2396 HRTELATQEKVTLVQTLE 2413
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1748
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1749 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1803
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1905
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2358 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2417
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2418 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2476
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2477 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2587 LAHSEEVTASQVA 2599
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2424 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2483 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2533
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Query: 387 TMGAAKVT 394
T T
Sbjct: 2594 TASQVAAT 2601
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1257
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1258 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1314
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2077
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2134
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1375 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1428
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1489 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1548 QVQVALETAQRSAE 1561
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1509
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1627
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1687
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1688 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1740
Query: 370 GPL 372
L
Sbjct: 1741 AEL 1743
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2166 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2404 HRTELATQEKVTLVQTLE 2421
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1756
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1757 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1811
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1913
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2366 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2425
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2426 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2484
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2485 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2595 LAHSEEVTASQVA 2607
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2432 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2491 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2541
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Query: 387 TMGAAKVT 394
T T
Sbjct: 2602 TASQVAAT 2609
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1265
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1266 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1322
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1323 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1382
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 62.4 bits (150), Expect = 8e-10
Identities = 72/281 (25%), Positives = 135/281 (48%), Gaps = 32/281 (11%)
Query: 117 VEEIYKDRQKFSEQVFKV-ASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKAR------ 168
VE+ + R++ E++ + AS + G + + L I + +D L S +A
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 169 ---TAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYL----SEIEMAKAQRDYELKKA 221
A+ ++ R E ++ E A+Q K + + + +++E A+ R+ +++
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 222 AYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ---EQEIARR--E 276
A +++ AQ L + + Q +EQ +Q Q +++ Q V Q E E ARR E
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQLRGEAEAARRAAE 2118
Query: 277 KELEARVRKPAEAERYK-----LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
+ EARV+ EA + + ERL ++ + Q +A+A+AA+ ++R EAE A
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAAR 2175
Query: 332 RAEAEQMA---KKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
RA+AEQ A K+A ++ + + L + QV +E++
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Score = 56.2 bits (134), Expect = 5e-08
Identities = 68/254 (26%), Positives = 118/254 (46%), Gaps = 33/254 (12%)
Query: 139 LVNMGISVVSYTLKDIHDDQ---DYLHSLGKARTAQVQ----KDARIGEAEAKRDAGI-R 190
L + I +S TL+ + +++ + + + R A+V+ K ++ EA A+ A R
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 191 EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIE 250
EAK Q+++ + + E A D + +K + E+ R ++ Q AK +Q
Sbjct: 1416 EAKELQQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQ---AKARQAEA 1469
Query: 251 EQRVQVQVVERAQQVAVQEQEIARR----EKELEARVRKPAEAERYKLERLAEAEK---- 302
+R ++++ E + V +Q + R+ E EL+A + EAE K + EAE+
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529
Query: 303 ----SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL------YQEAA 352
SQ QAE E AS R++ EAEA RA E++ +AE + + A
Sbjct: 1530 VQDESQRKRQAEVELAS-RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 353 QLDMLLEKLPQVAE 366
Q+ + LE + AE
Sbjct: 1589 QVQVALETAQRSAE 1602
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 34/303 (11%)
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
G E E+ + E + A E + + Q S++ + A +L S V
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-RQAEVELA----SRVKA 1550
Query: 150 TLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR--------DAGIREAKAKQEKVSA 201
+ + Q L +L + R + + R+ +AE +R + R A+A+ + A
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 202 QY----------LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEE 251
+ L E +A AQ E ++ A + RA+ + +L+ + K E
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEAERELERWQLKAN-EA 1668
Query: 252 QRVQVQVVERAQQ--VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQA 309
R+++Q E AQQ +A E E + E E EAR R AE + + LAE E + A
Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1728
Query: 310 EAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEIS 369
E A R+ E E R RAE EQ ++ + L +E A+L Q +E+
Sbjct: 1729 EG-TAQQRLAAEQELI----RLRAETEQGEQQRQL--LEEELARLQREAAAATQKRQELE 1781
Query: 370 GPL 372
L
Sbjct: 1782 AEL 1784
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK 133
Q Q + AA + + E E A A + Q A+ + + +KF+EQ +
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 134 VASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDAR---------------- 177
+ V ++ + L++ ++ L + A+ + AR
Sbjct: 2207 QKAQ--VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264
Query: 178 --IGEAEAKRDAGIREAKAKQEKVSAQYL-SEIEMAK--AQRDYELKKAAYDIEVNTRRA 232
+ + +A+ +A R + + + ++L E E K A+ L AA + + A
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 233 QADLAYQLQVA----KTKQQIEEQRVQVQV-VERAQQVAVQEQEIARREKELEARVRKPA 287
+ DLA Q +A K K Q ++ +++ E QQ QE ARR +E + ++ +
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 288 EAERYKLERLAEAEKS-QLIMQAEAEAASVRM----RGEAEAFAIGARARAEAEQMAKKA 342
E +R EAE+ QL M AEAE +R+ R +A A R R +AE++ +K
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 343 EAFQL-YQEAAQLDMLLE 359
+L QE L LE
Sbjct: 2445 HRTELATQEKVTLVQTLE 2462
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/233 (27%), Positives = 108/233 (46%), Gaps = 34/233 (14%)
Query: 168 RTAQVQKDARIGEAEAKRDAGIREAKAK-------------QEKVSAQYLSEIEMAKAQR 214
R AQ Q +A EA+R+ + KA Q+K AQ +E + +A+R
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 215 DYELKKAAYDIEVNTRR-AQADLAYQLQVAK-TKQQ---IEEQ--RVQVQVVERAQQVAV 267
+ + A + V R A+ +L Q Q+A+ T QQ E++ R++ + + QQ +
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
Query: 268 QEQEIARREKELEARVRKPAEAE------RYKLE-RLAEAEKSQLIMQAEAEAASVRMRG 320
E+E+AR ++E A +K E E R ++E LA +++ ++ +E + R+
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 321 EAEAF----AIGARARA---EAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
EA F AR RA EA++ + AE Q A +L EKL + E
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871
Score = 48.1 bits (113), Expect = 1e-05
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 32/222 (14%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDI 225
+A T Q ++ ++ E E R REA A +K + E E+AK + + E+ A+
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQ--REAAAATQK---RQELEAELAKVRAEMEVLLAS--- 1797
Query: 226 EVNTRRAQADLAYQLQVAKTKQQIEEQ--RVQVQVVERAQQVAVQEQEIARREKELEARV 283
+A+A+ + K+KQ++E + R + E A+ A+ E+ +R+ E
Sbjct: 1798 -----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1852
Query: 284 RKPAEAERYKLERLA--------EAEKSQLIMQAEAEAASVRMRGEAEAF------AIGA 329
R+ AEAER E+LA + E + + EAE +R E EAF A
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912
Query: 330 RARAEAEQ---MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ +A+ E+ +KA +L ++ ++ L + QV EEI
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1954
Score = 46.6 bits (109), Expect = 4e-05
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 18/253 (7%)
Query: 94 AEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFK--VASSDLVNMGISVVSYTL 151
AE + L E + A + K ++ E++ + +A+ + V + ++
Sbjct: 2407 AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2466
Query: 152 KDIHDDQDYLHSLGKARTAQ--VQKDARIGEAEAKRDAGIREAKAKQEKVSAQ--YLSEI 207
+ HD + ++ + + +Q++A++ + +++ +++ + QE + Q +LSE
Sbjct: 2467 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE- 2525
Query: 208 EMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVVERAQQVA 266
+D L++ + + +A+ + +Q +VAK +Q + E+QR Q Q+ + Q++
Sbjct: 2526 ------KDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 267 VQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFA 326
+E RR+ E E VR+ E E +LE+ ++ L + + +++ E A
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Query: 327 IGARARAEAEQMA 339
+ A Q+A
Sbjct: 2636 LAHSEEVTASQVA 2648
Score = 42.4 bits (98), Expect = 8e-04
Identities = 62/248 (25%), Positives = 107/248 (43%), Gaps = 29/248 (11%)
Query: 166 KARTAQVQKDARIGEAEAKR---------DAGIREAKAKQEKVSAQYLSEIEMAKAQRDY 216
K R A++ + E +A+R + R A QEKV+ EI+ ++ D
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 217 E-LKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE-IAR 274
E L++A ++E + Q + A LQ+ + Q +Q +Q + QQ + E++ + +
Sbjct: 2473 ERLREAIAELEREKEKLQQE-AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 275 REKELEARVRKPAEAERYKLERLAEAE--KSQLIMQAEAEAASVRMRGEAEAFAI----G 328
RE+ +E E+ KLE+L + E K+Q + + E + +M E +
Sbjct: 2532 RERFIEQ--------EKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEA 2582
Query: 329 ARARAEAEQ--MAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSG 386
R + EAE+ K+ E QL Q+ Q + LL + Q E L ++ L S
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Query: 387 TMGAAKVT 394
T T
Sbjct: 2643 TASQVAAT 2650
Score = 33.1 bits (74), Expect = 0.49
Identities = 47/238 (19%), Positives = 95/238 (39%), Gaps = 26/238 (10%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMA 210
L+D Q+ + ++ A + V++ R +A + E + ++ + QY++ I
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI--- 1306
Query: 211 KAQRDYELKKAAYDIEVNTRRAQA-----------------DLA--YQLQVAKTKQQIEE 251
+DYEL+ Y ++ + A DL Y T Q I+
Sbjct: 1307 ---KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF 1363
Query: 252 QRVQVQVVERAQQVAVQEQ-EIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
++ +E +++A Q++ E R E+EA + K + + A+AE+ +Q
Sbjct: 1364 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1423
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ VR A R+ E Q +++ ++ +A Q + ++ EEI
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.7 bits (143), Expect = 5e-09
Identities = 60/246 (24%), Positives = 113/246 (45%), Gaps = 13/246 (5%)
Query: 150 TLKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQY 203
TL D+ ++D +++L KA+ + Q D G E E K + AK K E K++ +
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 204 LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQ 263
+ +IE K Q D +LKK ++I + + + A +Q+ K +I+E +Q ++ E +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK---KIKE--LQARIEELEE 1126
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
++ + A+ EK+ R+ E +LE A +Q+ M + EA +MR + E
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISE-RLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTS-ANKITLVS 382
+ A A + +L ++ L + +KL + E+ + A+ + VS
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 383 SGSGTM 388
G +
Sbjct: 1246 KAKGNL 1251
Score = 35.0 bits (79), Expect = 0.13
Identities = 75/361 (20%), Positives = 150/361 (41%), Gaps = 73/361 (20%)
Query: 72 KIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT--VEEIYKDRQKFSE 129
+++ KE + ++F K E + LETL+ + + ++ E+I + ++ E
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 130 --QVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDA 187
++ K + + ++ H++ L + + + D +I E + + D
Sbjct: 1532 LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 188 ----GIREAKAKQEKVSAQY----------------LSEIEM---------AKAQRDYE- 217
IR ++ Q + A+ L+E+E+ A+A R+Y
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 218 ----LKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-----QIEEQRVQVQVVERAQQVAVQ 268
LK ++ + R+Q DL QL + + + +IEE R ++ ER++++A Q
Sbjct: 1652 TQGILKDTQIHLD-DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 269 EQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIG 328
E L+A +ER +L L S + + + E +M+GE E
Sbjct: 1711 EL--------LDA-------SERVQL--LHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Query: 329 ARARAEAEQMAKKA--EAFQLYQE-------AAQLDMLLEKLPQVAEEISGPLTSANKIT 379
AR AE+ AKKA +A + +E +A L+ + + + Q +++ L A ++
Sbjct: 1754 AR---NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 380 L 380
L
Sbjct: 1811 L 1811
Score = 33.9 bits (76), Expect = 0.29
Identities = 28/137 (20%), Positives = 62/137 (45%), Gaps = 20/137 (14%)
Query: 237 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER 296
A+ Q+ + K+Q+EE+ + A Q + + ++ R E+Y+ E+
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR---------------EQYEEEQ 1357
Query: 297 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEA----- 351
++AE + + +A E A R + E +A +++A++ +A + + EA
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 352 AQLDMLLEKLPQVAEEI 368
A L+ ++L E++
Sbjct: 1418 ASLEKTKQRLQNEVEDL 1434
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.7 bits (143), Expect = 5e-09
Identities = 60/246 (24%), Positives = 113/246 (45%), Gaps = 13/246 (5%)
Query: 150 TLKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQY 203
TL D+ ++D +++L KA+ + Q D G E E K + AK K E K++ +
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 204 LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQ 263
+ +IE K Q D +LKK ++I + + + A +Q+ K +I+E +Q ++ E +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK---KIKE--LQARIEELEE 1126
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
++ + A+ EK+ R+ E +LE A +Q+ M + EA +MR + E
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISE-RLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTS-ANKITLVS 382
+ A A + +L ++ L + +KL + E+ + A+ + VS
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 383 SGSGTM 388
G +
Sbjct: 1246 KAKGNL 1251
Score = 35.0 bits (79), Expect = 0.13
Identities = 75/361 (20%), Positives = 150/361 (41%), Gaps = 73/361 (20%)
Query: 72 KIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT--VEEIYKDRQKFSE 129
+++ KE + ++F K E + LETL+ + + ++ E+I + ++ E
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 130 --QVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDA 187
++ K + + ++ H++ L + + + D +I E + + D
Sbjct: 1532 LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 188 ----GIREAKAKQEKVSAQY----------------LSEIEM---------AKAQRDYE- 217
IR ++ Q + A+ L+E+E+ A+A R+Y
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 218 ----LKKAAYDIEVNTRRAQADLAYQLQVAKTKQ-----QIEEQRVQVQVVERAQQVAVQ 268
LK ++ + R+Q DL QL + + + +IEE R ++ ER++++A Q
Sbjct: 1652 TQGILKDTQIHLD-DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 269 EQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIG 328
E L+A +ER +L L S + + + E +M+GE E
Sbjct: 1711 EL--------LDA-------SERVQL--LHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Query: 329 ARARAEAEQMAKKA--EAFQLYQE-------AAQLDMLLEKLPQVAEEISGPLTSANKIT 379
AR AE+ AKKA +A + +E +A L+ + + + Q +++ L A ++
Sbjct: 1754 AR---NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 380 L 380
L
Sbjct: 1811 L 1811
Score = 33.9 bits (76), Expect = 0.29
Identities = 28/137 (20%), Positives = 62/137 (45%), Gaps = 20/137 (14%)
Query: 237 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER 296
A+ Q+ + K+Q+EE+ + A Q + + ++ R E+Y+ E+
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR---------------EQYEEEQ 1357
Query: 297 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEA----- 351
++AE + + +A E A R + E +A +++A++ +A + + EA
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 352 AQLDMLLEKLPQVAEEI 368
A L+ ++L E++
Sbjct: 1418 ASLEKTKQRLQNEVEDL 1434
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 55.8 bits (133), Expect = 7e-08
Identities = 59/246 (23%), Positives = 112/246 (45%), Gaps = 13/246 (5%)
Query: 150 TLKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQY 203
TL D+ ++D +++L KA+ + Q D G E E K + AK K E K++ +
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069
Query: 204 LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQ 263
+IE K Q D +LKK +++ + + + A +Q+ K +I+E +Q ++ E +
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQK---KIKE--LQARIEELEE 1124
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
++ + A+ EK+ R+ E +LE A +Q+ M + EA +MR + E
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISE-RLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTS-ANKITLVS 382
+ A A + +L ++ L + +KL + E+ + A+ + VS
Sbjct: 1184 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 383 SGSGTM 388
G +
Sbjct: 1244 KAKGNL 1249
Score = 35.0 bits (79), Expect = 0.13
Identities = 75/360 (20%), Positives = 152/360 (42%), Gaps = 71/360 (19%)
Query: 72 KIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT--VEEIYKDRQKFSE 129
+++ KE + + ++F K E + LETL+ + + ++ E+I + ++ E
Sbjct: 1470 ELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1529
Query: 130 --QVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDA 187
++ K + + ++ H++ L + + + D +I E + + D
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1589
Query: 188 ----GIREAKAKQEKVSAQY----------------LSEIEM---------AKAQRDYEL 218
IR ++ Q + A+ L+E+E+ A+A R+Y
Sbjct: 1590 MKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1649
Query: 219 KKAAY-DIEVN---TRRAQADLAYQLQVAKTKQ-----QIEEQRVQVQVVERAQQVAVQE 269
+A D +++ R+Q DL QL + + + +IEE R ++ ER++++A QE
Sbjct: 1650 TQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1709
Query: 270 QEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGA 329
L+A +ER +L L S + + + E +++GE E A
Sbjct: 1710 L--------LDA-------SERVQL--LHTQNTSLINTKKKLETDISQIQGEMEDIIQEA 1752
Query: 330 RARAEAEQMAKKA--EAFQLYQE-------AAQLDMLLEKLPQVAEEISGPLTSANKITL 380
R AE+ AKKA +A + +E +A L+ + + L Q +++ L A ++ L
Sbjct: 1753 R---NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Score = 33.5 bits (75), Expect = 0.38
Identities = 34/189 (17%), Positives = 86/189 (45%), Gaps = 25/189 (13%)
Query: 189 IREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVN----TRRAQADLAYQLQVAK 244
+ E K K+E+ + ++++ +A+ E + + ++ ++ ++ A+ Q+ +
Sbjct: 1260 LSEIKTKEEE-QQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 245 TKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQ 304
K+Q+EE+ + A Q + + ++ R E+Y+ E+ A+AE +
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLR---------------EQYEEEQEAKAELQR 1363
Query: 305 LIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEA-----AQLDMLLE 359
+ +A +E A R + E +A +++A++ + + + EA A L+ +
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 360 KLPQVAEEI 368
+L E++
Sbjct: 1424 RLQNEVEDL 1432
>gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens]
Length = 356
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/255 (19%), Positives = 113/255 (44%), Gaps = 20/255 (7%)
Query: 9 EAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRI-SLNTLTLNVKSEKVYTRHGVPISVTG 67
EA VV R ++ G + + P + +I+ + SL + +NV + T V + + G
Sbjct: 45 EAWVVERMGRFHRILEPGLNILI-PVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDG 103
Query: 68 IAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKF 127
+ ++I K E + +A T+ R+ + +++++++++R+
Sbjct: 104 VLYLRIMDPYKASYGVE------DPEYAVTQLAQTTM----RSELGKLSLDKVFRERESL 153
Query: 128 SEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDA 187
+ + + GI + Y +KDIH S+ A+ +K A + E+E R++
Sbjct: 154 NASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRES 213
Query: 188 GIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADL-AYQLQVAKTK 246
I A+ K++ ++I ++A++ ++ +AA + +A+A A ++ A
Sbjct: 214 AINVAEGKKQ-------AQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALT 266
Query: 247 QQIEEQRVQVQVVER 261
Q + + V E+
Sbjct: 267 QHNGDAAASLTVAEQ 281
Score = 37.0 bits (84), Expect = 0.034
Identities = 52/205 (25%), Positives = 85/205 (41%), Gaps = 34/205 (16%)
Query: 220 KAAYDIE----VNTRRAQADLAYQL-QVAKTKQQIEEQRVQVQVVERAQQVA-------- 266
KA+Y +E T+ AQ + +L +++ K E + + +V+ Q A
Sbjct: 114 KASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCL 173
Query: 267 ---VQEQEIARREKE-----LEARVRKPA-----EAERYKLERLAEAEKSQLIMQAEAEA 313
+++ + R KE +EA RK A E R +AE +K I+ +EAE
Sbjct: 174 RYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEK 233
Query: 314 ASV--RMRGEAEAFAIGARARAEAEQMAKKA------EAFQLYQEAAQLDMLLEKLPQVA 365
A + GEA A A+A+AEA ++ A +A A Q KL + +
Sbjct: 234 AEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDS 293
Query: 366 EEISGPLTSANKITLVSSGSGTMGA 390
I P + ++V+ G GA
Sbjct: 294 NTILLPSNPGDVTSMVAQAMGVYGA 318
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 54.3 bits (129), Expect = 2e-07
Identities = 59/253 (23%), Positives = 113/253 (44%), Gaps = 18/253 (7%)
Query: 150 TLKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQY 203
TL D+ ++D +++L KA+T + Q D G E E K + AK K E K++ +
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069
Query: 204 LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQ 263
+ E K Q + +LKK +++ + + + A +Q+ K +++ Q ++ E +
Sbjct: 1070 TMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL-----QARIEELEE 1124
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
++ + A+ EK+ R+ E +LE A +Q+ M + EA +MR + E
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISE-RLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSS 383
+ A A A + +L ++ L + +KL + E+ +I ++S
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELK------MEINDLAS 1237
Query: 384 GSGTMGAAKVTGE 396
T+ AK E
Sbjct: 1238 NMETVSKAKANFE 1250
Score = 38.1 bits (87), Expect = 0.015
Identities = 45/225 (20%), Positives = 102/225 (45%), Gaps = 32/225 (14%)
Query: 153 DIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKA 212
+I+D + ++ KA+ A +K R E + + E K K+E+ + ++E+ KA
Sbjct: 1231 EINDLASNMETVSKAK-ANFEKMCRTLEDQ------LSEIKTKEEE-QQRLINELSAQKA 1282
Query: 213 QRDYELKKAAYDIEVN----TRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ 268
+ E + + ++ ++ ++ A+ Q+ + K+Q+EE+ + A Q A
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 269 EQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIG 328
+ ++ R E+Y+ E+ A+AE + + +A +E A R + E +A
Sbjct: 1343 DCDLLR---------------EQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1387
Query: 329 ARARAEAEQMAKKAEAFQLYQEA-----AQLDMLLEKLPQVAEEI 368
+++A++ + + + EA A L+ ++L E++
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 53.9 bits (128), Expect = 3e-07
Identities = 51/223 (22%), Positives = 102/223 (45%), Gaps = 12/223 (5%)
Query: 151 LKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQYL 204
L D+ ++D ++SL K++ + Q D G E E K + AK K E K++ + +
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 205 SEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQ 264
++E K Q + +LKK +DI + + + LQ+ K +++E + +++ +E +
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQK---KLKENQARIEELEEELE 1125
Query: 265 VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEA 324
E+ + ++L + + + E +LE A Q+ M + EA +MR + E
Sbjct: 1126 A---ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 325 FAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEE 367
+ A A A + +L ++ L + +KL + E
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Score = 45.4 bits (106), Expect = 1e-04
Identities = 77/352 (21%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 69 AQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFS 128
+Q +++ KE + + ++F K E + LET + + + EEI ++
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ-----EEISDLTEQLG 1519
Query: 129 EQVFKVASSDLVNMGISVVSYTLKDIHDDQDYL--HSLGKARTAQV---QKDARIGEAEA 183
E V + V + V L+ ++ + H GK AQ+ Q A I A
Sbjct: 1520 EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1579
Query: 184 KRDAGIREAKAKQEKV--------SAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQAD 235
++D + +AK ++V A+ S E+ + ++ E +I+++ A
Sbjct: 1580 EKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAA 1639
Query: 236 LAYQLQVAKTKQQIEEQRVQ--------------VQVVERAQQVAVQEQEIARREKELEA 281
A Q QV + +++ ++Q + +VER + E E R E
Sbjct: 1640 EA-QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1698
Query: 282 RVRKPAEAERYKLE---RLAEAEKSQLIMQ-AEAEAASVRMRGEAEAFAIGARARAEAEQ 337
R RK AE E + +L ++ + LI Q + E+ +++ E E R AE+
Sbjct: 1699 RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR---NAEE 1755
Query: 338 MAKKA--EAFQLYQE-------AAQLDMLLEKLPQVAEEISGPLTSANKITL 380
AKKA +A + +E +A L+ + + + Q +++ L A +I L
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1807
Score = 37.0 bits (84), Expect = 0.034
Identities = 45/186 (24%), Positives = 77/186 (41%), Gaps = 39/186 (20%)
Query: 189 IREAKAKQEKVSAQYLSE-----IEMAKAQR---DYELKKAAYDIEVNTRRAQAD----- 235
I +AKA EKVS + +++ +AQR D+ ++A E Q +
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
Query: 236 --------LAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPA 287
L+Y Q+ K+Q+EE+ + A Q A + ++ R
Sbjct: 1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR------------- 1346
Query: 288 EAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL 347
E+Y+ E A+AE +++ +A +E A R + E +A R E K A+ Q
Sbjct: 1347 --EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI---QRTEELEEAKKKLAQRLQD 1401
Query: 348 YQEAAQ 353
+EA +
Sbjct: 1402 AEEAVE 1407
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 53.5 bits (127), Expect = 4e-07
Identities = 52/199 (26%), Positives = 88/199 (44%), Gaps = 11/199 (5%)
Query: 185 RDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAK 244
++ I + KQE+ Q EI + + + ++A E R +A+ +++ +
Sbjct: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA----EAERARLEAEERERIKAEQ 284
Query: 245 TKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQ 304
K+ I ++R +++ E+A + +E RE+ E R E +R K E AE+ Q
Sbjct: 285 DKK-IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 305 LIMQAEAEAASVRMR---GEAEAFAIGARARAEAEQMAKKAEA---FQLYQEAAQLDMLL 358
I + E AA R R E A RARAE E+ AK E QL ++ +
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETK 403
Query: 359 EKLPQVAEEISGPLTSANK 377
K +V ++I G + K
Sbjct: 404 IKGEKVEQKIEGKWVNEKK 422
Score = 32.7 bits (73), Expect = 0.65
Identities = 37/177 (20%), Positives = 79/177 (44%), Gaps = 23/177 (12%)
Query: 166 KARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSA-----QYLSEIEMAKAQ-RDYELK 219
+A+ ++Q+D + E +D I++ K +E+V + + +E++ + ++LK
Sbjct: 445 QAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLK 504
Query: 220 KAAYDIEVNTRRAQADL-----AYQLQVAKTKQQIEEQRVQVQVVE------RAQQVAVQ 268
RA D A Q++ K +++ +R + + E + Q+ A++
Sbjct: 505 HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE 564
Query: 269 EQEIARREKEL------EARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMR 319
+E+ ++ +E E + RK EA+R E + + I + AEAA R +
Sbjct: 565 LEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQK 621
Score = 32.0 bits (71), Expect = 1.1
Identities = 55/243 (22%), Positives = 110/243 (45%), Gaps = 36/243 (14%)
Query: 154 IHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSA---QYLSEIEMA 210
I +QD + +AR +K A + +R+A RE ++EK +A Q + E E
Sbjct: 280 IKAEQDKKIADERARIEAEEKAA--AQERERREAEERERMREEEKRAAEERQRIKEEEKR 337
Query: 211 KA---QRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQ----IEEQRVQVQVVERAQ 263
A QR E +K A + + + A + Q A+ +++ +EEQ+ Q+ E+
Sbjct: 338 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
A+QE +I + +++E ++ ++ E+ A+ +K Q A ++ +GE +
Sbjct: 398 --AMQETKI--KGEKVEQKIE-----GKWVNEKKAQEDKLQ--------TAVLKKQGEEK 440
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSS 383
G + +A+ E++ + F ++ D ++K + EE+ + T V S
Sbjct: 441 ----GTKVQAKREKLQEDKPTF---KKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 493
Query: 384 GSG 386
+G
Sbjct: 494 QNG 496
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 53.1 bits (126), Expect = 5e-07
Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 12/225 (5%)
Query: 150 TLKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQY 203
TL D+ ++D ++ L K + Q D G E E K A + AK K E K+S +
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 204 LSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQ 263
+ ++E K Q + +LKK +++ + + + LQ K +++ Q ++ E +
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL-----QARIEELEE 1124
Query: 264 QVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAE 323
++ + A+ EK+ R+ E +LE + A +Q+ M + EA +MR + E
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISE-RLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 324 AFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEI 368
+ A A + + +L ++ L + +KL + E+
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSEL 1228
Score = 39.3 bits (90), Expect = 0.007
Identities = 47/205 (22%), Positives = 93/205 (45%), Gaps = 33/205 (16%)
Query: 153 DIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKA 212
+I D + +L K+++ +++ R E + E KAK E+ Q + ++ M KA
Sbjct: 1231 EIDDMASNIEALSKSKS-NIERTCRTVEDQ------FSEIKAKDEQ-QTQLIHDLNMQKA 1282
Query: 213 QRDYELKKAAYDIEVN----TRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQ 268
+ + + ++ +E ++ ++ A Q+ + K+Q+EE+ + A Q +
Sbjct: 1283 RLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRH 1342
Query: 269 EQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIG 328
+ ++ R E+Y+ E+ A+AE + + +A +E A R + E +A
Sbjct: 1343 DCDLLR---------------EQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI--- 1384
Query: 329 ARARAEAEQMAKKAEAFQLYQEAAQ 353
R E + AKK A Q QEA +
Sbjct: 1385 --QRTEELEEAKKKLA-QRLQEAEE 1406
Score = 38.5 bits (88), Expect = 0.012
Identities = 55/240 (22%), Positives = 105/240 (43%), Gaps = 19/240 (7%)
Query: 151 LKDIHDDQDYLHSLGKARTAQVQK-DARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEM 209
L D D LHS + +K +A I + +A+ + I+E++ +EK M
Sbjct: 1710 LLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMM 1769
Query: 210 AKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQE 269
A+ ELKK D + R + +L Q K Q ++ Q+ + +Q+ E
Sbjct: 1770 AE-----ELKKEQ-DTSAHLERMKKNLE---QTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 270 QEIARREKELEARVRKPAEAER--YKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAI 327
+ E EL+ ++ AEA + +K ER + ++ QAE + ++ +R + +
Sbjct: 1821 NRVRELENELDVEQKRGAEALKGAHKYER----KVKEMTYQAEEDHKNI-LRLQDLVDKL 1875
Query: 328 GARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGT 387
A+ ++ Q A++AE Q + ++ + +L + AE + NK+ S G+
Sbjct: 1876 QAKVKSYKRQ-AEEAEE-QANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGS 1933
Score = 34.3 bits (77), Expect = 0.22
Identities = 61/290 (21%), Positives = 124/290 (42%), Gaps = 36/290 (12%)
Query: 74 QGQNKEMLAAACQMFLGKTEAEIAHIALE-TLEGHQRAIMAHMTVEEIYKDRQKFSEQVF 132
Q + ++ A Q L K +E+A + + QR EE+ + ++K ++++
Sbjct: 1350 QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT-------EELEEAKKKLAQRLQ 1402
Query: 133 KVA-SSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKARTAQVQKDAR-------IGEAEA 183
+ +++ N + + T + + + +D + L ++ TA D + + E +
Sbjct: 1403 EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQ 1462
Query: 184 KRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDY---------ELKKAAYDIEVNTRRAQA 234
K D E +A Q++ + +M A + E K +I T + A
Sbjct: 1463 KLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI-A 1521
Query: 235 DLAYQLQVA-KTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYK 293
+ LQ A KTK+ +E+++ +QV + +++ +E +LE K +E +R
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK-SELDRKV 1580
Query: 294 LERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAE 343
+E+ E E+ + Q AEA + E R+R +A ++ KK E
Sbjct: 1581 IEKDEEIEQLKRNSQRAAEALQSVLDAE-------IRSRNDALRLKKKME 1623
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 53.1 bits (126), Expect = 5e-07
Identities = 58/255 (22%), Positives = 115/255 (45%), Gaps = 38/255 (14%)
Query: 168 RTAQVQKDAR--IGEAEAKRDAGIR---EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAA 222
R +V++D R + E + KR+ +R +A+ + E++ + +IE AQ D + +KA
Sbjct: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Query: 223 YDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE------IARRE 276
+ R + A + AK +++E +R Q + R + + +E+E + +++
Sbjct: 615 EE------RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
Query: 277 KELEARVRKPAEA--------------ERYKLERLAEAEKSQLIMQAEAEAASVRMRGEA 322
+E + R+RK AEA ER + ER + + Q + E + A R E
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ 728
Query: 323 EAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVS 382
E R +AE E + ++ +A +L +E Q ++ +K + + ++ +
Sbjct: 729 E------RLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
Query: 383 SGSGTMGAAKVTGEV 397
+G A VT +V
Sbjct: 782 EAAGASKALNVTVDV 796
Score = 37.4 bits (85), Expect = 0.026
Identities = 50/246 (20%), Positives = 106/246 (43%), Gaps = 18/246 (7%)
Query: 96 IAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIH 155
+ + L+ E ++ + A VE++ ++++K EQ F I + K+
Sbjct: 567 LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ---------IDEKTEKAKEER 617
Query: 156 DDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIR-EAKAKQEKVSAQYLSEIEMAKAQR 214
++ A+ + + R E EA+R ++ E + ++ + Q E E + ++
Sbjct: 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
Query: 215 DYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERA--QQVAVQEQEI 272
E K+ A E R + + + + +Q+ EQ Q+ ER Q+ E+E+
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAEREL 737
Query: 273 ARREKEL---EARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGA 329
REK L + ++++ E ++ K E+ AE+ +Q E E + G ++A +
Sbjct: 738 QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ---LQEEQEKKAKEAAGASKALNVTV 794
Query: 330 RARAEA 335
++ A
Sbjct: 795 DVQSPA 800
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 53.1 bits (126), Expect = 5e-07
Identities = 58/255 (22%), Positives = 115/255 (45%), Gaps = 38/255 (14%)
Query: 168 RTAQVQKDAR--IGEAEAKRDAGIR---EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAA 222
R +V++D R + E + KR+ +R +A+ + E++ + +IE AQ D + +KA
Sbjct: 551 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
Query: 223 YDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE------IARRE 276
+ R + A + AK +++E +R Q + R + + +E+E + +++
Sbjct: 611 EE------RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 277 KELEARVRKPAEA--------------ERYKLERLAEAEKSQLIMQAEAEAASVRMRGEA 322
+E + R+RK AEA ER + ER + + Q + E + A R E
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ 724
Query: 323 EAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVS 382
E R +AE E + ++ +A +L +E Q ++ +K + + ++ +
Sbjct: 725 E------RLQAERE-LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
Query: 383 SGSGTMGAAKVTGEV 397
+G A VT +V
Sbjct: 778 EAAGASKALNVTVDV 792
Score = 37.7 bits (86), Expect = 0.020
Identities = 57/292 (19%), Positives = 123/292 (42%), Gaps = 22/292 (7%)
Query: 54 KVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAE----IAHIALETLEGHQR 109
K + + P+ + + + + +N A Q+ K E + + + L+ E ++
Sbjct: 517 KSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK 576
Query: 110 AIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKART 169
+ A VE++ ++++K EQ F I + K+ ++ A+
Sbjct: 577 VLQARERVEQMKEEKKKQIEQKFAQ---------IDEKTEKAKEERLAEEKAKKKAAAKK 627
Query: 170 AQVQKDARIGEAEAKRDAGIR-EAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVN 228
+ + R E EA+R ++ E + ++ + Q E E + ++ E K+ A E
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 687
Query: 229 TRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERA--QQVAVQEQEIARREKEL---EARV 283
R + + + + +Q+ EQ Q+ ER Q+ E+E+ REK L + ++
Sbjct: 688 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL 747
Query: 284 RKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEA 335
++ E ++ K E+ AE+ +Q E E + G ++A + ++ A
Sbjct: 748 QRELEEKKKKEEQQRLAERQ---LQEEQEKKAKEAAGASKALNVTVDVQSPA 796
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 52.8 bits (125), Expect = 6e-07
Identities = 56/207 (27%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 159 DYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYEL 218
+ L L KA+ A+++++ R E AKR+ E + +QE++ Q + E+ + Q++ E
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKRE---EEERKRQEELRRQ---QEEILRRQQEEER 771
Query: 219 KKAAYDIEVNTRRAQADLAYQLQ--VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE 276
K+ + E+ R+ + L Q + +A +Q+ EE+R Q + R + +E+E R++
Sbjct: 772 KRREEE-ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 830
Query: 277 KELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAE 336
+EL R ++ A+ + E A+ + ++ E EAA R+R E E R R E E
Sbjct: 831 EEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA--RLRHEEE-----ERKRKELE 882
Query: 337 QMAKKAEAFQLYQEAAQLDMLLEKLPQ 363
+K Q Q+ L L ++ Q
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQ 909
Score = 38.9 bits (89), Expect = 0.009
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 10/141 (7%)
Query: 221 AAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVV--------ERAQQVAVQEQE 271
+ +D+ ++T L Q+ K K ++E++R + ++ +R +++ Q++E
Sbjct: 702 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 761
Query: 272 IARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
I RR++E E + R+ E R K E ++ Q I R + E EA
Sbjct: 762 ILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE-EALRRLEER 820
Query: 332 RAEAEQMAKKAEAFQLYQEAA 352
R E E+ K+ E + +E A
Sbjct: 821 RREEEERRKQEELLRKQEEEA 841
Score = 29.6 bits (65), Expect = 5.5
Identities = 33/191 (17%), Positives = 84/191 (43%), Gaps = 13/191 (6%)
Query: 180 EAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQ 239
E +++ +R + ++ + + E E+ + Q + K A + E R + L +
Sbjct: 805 EERQQQEEALRRLEERRREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRME 863
Query: 240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE 299
+ A+ + + EE++ + V+R Q++ + +R+++ EA R + ++ +L ++
Sbjct: 864 EEAARLRHEEEERKRKELEVQR------QKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 917
Query: 300 AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLE 359
S Q+ A +++A A + E+ ++ Q Q+ + L +
Sbjct: 918 PSSSTWGQQSNTTAC------QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQ 971
Query: 360 KLPQVAEEISG 370
+ Q +++SG
Sbjct: 972 QQQQQQQKLSG 982
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 52.8 bits (125), Expect = 6e-07
Identities = 56/207 (27%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 159 DYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYEL 218
+ L L KA+ A+++++ R E AKR+ E + +QE++ Q + E+ + Q++ E
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKRE---EEERKRQEELRRQ---QEEILRRQQEEER 798
Query: 219 KKAAYDIEVNTRRAQADLAYQLQ--VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE 276
K+ + E+ R+ + L Q + +A +Q+ EE+R Q + R + +E+E R++
Sbjct: 799 KRREEE-ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 857
Query: 277 KELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAE 336
+EL R ++ A+ + E A+ + ++ E EAA R+R E E R R E E
Sbjct: 858 EEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA--RLRHEEE-----ERKRKELE 909
Query: 337 QMAKKAEAFQLYQEAAQLDMLLEKLPQ 363
+K Q Q+ L L ++ Q
Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQ 936
Score = 38.9 bits (89), Expect = 0.009
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 10/141 (7%)
Query: 221 AAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVV--------ERAQQVAVQEQE 271
+ +D+ ++T L Q+ K K ++E++R + ++ +R +++ Q++E
Sbjct: 729 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 788
Query: 272 IARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
I RR++E E + R+ E R K E ++ Q I R + E EA
Sbjct: 789 ILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE-EALRRLEER 847
Query: 332 RAEAEQMAKKAEAFQLYQEAA 352
R E E+ K+ E + +E A
Sbjct: 848 RREEEERRKQEELLRKQEEEA 868
Score = 29.6 bits (65), Expect = 5.5
Identities = 33/191 (17%), Positives = 84/191 (43%), Gaps = 13/191 (6%)
Query: 180 EAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQ 239
E +++ +R + ++ + + E E+ + Q + K A + E R + L +
Sbjct: 832 EERQQQEEALRRLEERRREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRME 890
Query: 240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE 299
+ A+ + + EE++ + V+R Q++ + +R+++ EA R + ++ +L ++
Sbjct: 891 EEAARLRHEEEERKRKELEVQR------QKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 944
Query: 300 AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLE 359
S Q+ A +++A A + E+ ++ Q Q+ + L +
Sbjct: 945 PSSSTWGQQSNTTAC------QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQ 998
Query: 360 KLPQVAEEISG 370
+ Q +++SG
Sbjct: 999 QQQQQQQKLSG 1009
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 52.8 bits (125), Expect = 6e-07
Identities = 56/207 (27%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 159 DYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYEL 218
+ L L KA+ A+++++ R E AKR+ E + +QE++ Q + E+ + Q++ E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKRE---EEERKRQEELRRQ---QEEILRRQQEEER 777
Query: 219 KKAAYDIEVNTRRAQADLAYQLQ--VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE 276
K+ + E+ R+ + L Q + +A +Q+ EE+R Q + R + +E+E R++
Sbjct: 778 KRREEE-ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 277 KELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAE 336
+EL R ++ A+ + E A+ + ++ E EAA R+R E E R R E E
Sbjct: 837 EEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA--RLRHEEE-----ERKRKELE 888
Query: 337 QMAKKAEAFQLYQEAAQLDMLLEKLPQ 363
+K Q Q+ L L ++ Q
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQ 915
Score = 38.9 bits (89), Expect = 0.009
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 10/141 (7%)
Query: 221 AAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVV--------ERAQQVAVQEQE 271
+ +D+ ++T L Q+ K K ++E++R + ++ +R +++ Q++E
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767
Query: 272 IARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
I RR++E E + R+ E R K E ++ Q I R + E EA
Sbjct: 768 ILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE-EALRRLEER 826
Query: 332 RAEAEQMAKKAEAFQLYQEAA 352
R E E+ K+ E + +E A
Sbjct: 827 RREEEERRKQEELLRKQEEEA 847
Score = 29.6 bits (65), Expect = 5.5
Identities = 33/191 (17%), Positives = 84/191 (43%), Gaps = 13/191 (6%)
Query: 180 EAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQ 239
E +++ +R + ++ + + E E+ + Q + K A + E R + L +
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE 299
+ A+ + + EE++ + V+R Q++ + +R+++ EA R + ++ +L ++
Sbjct: 870 EEAARLRHEEEERKRKELEVQR------QKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 300 AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLE 359
S Q+ A +++A A + E+ ++ Q Q+ + L +
Sbjct: 924 PSSSTWGQQSNTTAC------QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQ 977
Query: 360 KLPQVAEEISG 370
+ Q +++SG
Sbjct: 978 QQQQQQQKLSG 988
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 52.8 bits (125), Expect = 6e-07
Identities = 56/207 (27%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 159 DYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYEL 218
+ L L KA+ A+++++ R E AKR+ E + +QE++ Q + E+ + Q++ E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKRE---EEERKRQEELRRQ---QEEILRRQQEEER 777
Query: 219 KKAAYDIEVNTRRAQADLAYQLQ--VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARRE 276
K+ + E+ R+ + L Q + +A +Q+ EE+R Q + R + +E+E R++
Sbjct: 778 KRREEE-ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 277 KELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAE 336
+EL R ++ A+ + E A+ + ++ E EAA R+R E E R R E E
Sbjct: 837 EEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA--RLRHEEE-----ERKRKELE 888
Query: 337 QMAKKAEAFQLYQEAAQLDMLLEKLPQ 363
+K Q Q+ L L ++ Q
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQ 915
Score = 38.9 bits (89), Expect = 0.009
Identities = 34/141 (24%), Positives = 64/141 (45%), Gaps = 10/141 (7%)
Query: 221 AAYDIEVNTRRAQADLAYQLQVAKTKQ-QIEEQRVQVQVV--------ERAQQVAVQEQE 271
+ +D+ ++T L Q+ K K ++E++R + ++ +R +++ Q++E
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767
Query: 272 IARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA 331
I RR++E E + R+ E R K E ++ Q I R + E EA
Sbjct: 768 ILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQE-EALRRLEER 826
Query: 332 RAEAEQMAKKAEAFQLYQEAA 352
R E E+ K+ E + +E A
Sbjct: 827 RREEEERRKQEELLRKQEEEA 847
Score = 29.6 bits (65), Expect = 5.5
Identities = 33/191 (17%), Positives = 84/191 (43%), Gaps = 13/191 (6%)
Query: 180 EAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQ 239
E +++ +R + ++ + + E E+ + Q + K A + E R + L +
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQE-ELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 240 LQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE 299
+ A+ + + EE++ + V+R Q++ + +R+++ EA R + ++ +L ++
Sbjct: 870 EEAARLRHEEEERKRKELEVQR------QKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 300 AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLE 359
S Q+ A +++A A + E+ ++ Q Q+ + L +
Sbjct: 924 PSSSTWGQQSNTTAC------QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQ 977
Query: 360 KLPQVAEEISG 370
+ Q +++SG
Sbjct: 978 QQQQQQQKLSG 988
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 52.4 bits (124), Expect = 8e-07
Identities = 53/223 (23%), Positives = 100/223 (44%), Gaps = 12/223 (5%)
Query: 151 LKDIHDDQDYLHSLGKARTA-QVQKDARIG--EAEAKRDAGIREAKAKQE---KVSAQYL 204
L D+ ++D +++L KA+ + Q D G E E K + AK K E K++ + +
Sbjct: 1007 LDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 205 SEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQ 264
++E K Q D LKK +++ R + + A Q+ K +++ Q ++ E ++
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL-----QARIEELEEE 1121
Query: 265 VAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEA 324
+ + A+ EK L + + + E +LE A Q+ M + EA +MR + E
Sbjct: 1122 LEAERTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
Query: 325 FAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEE 367
+ A A A + +L ++ L + +KL + E
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Score = 38.9 bits (89), Expect = 0.009
Identities = 72/351 (20%), Positives = 141/351 (40%), Gaps = 47/351 (13%)
Query: 69 AQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFS 128
+Q +++ KE + + ++F K E + LET + + + EEI ++
Sbjct: 1463 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ-----EEISDLTEQLG 1517
Query: 129 EQVFKVASSDLVNMGISVVSYTLKDIHDDQDYL--HSLGKARTAQV---QKDARIGEAEA 183
+ + V + L+ ++ + H GK AQ+ Q A I A
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 184 KRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELK-KAAYDIEVNTRRAQADLAYQL-- 240
++D + +AK +V + ++ R+ L+ K + ++N Q A ++
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Query: 241 ----QVAKTKQQIEEQRVQ--------------VQVVERAQQVAVQEQEIARREKELEAR 282
QV + +++ ++Q + +VER + E E R E R
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697
Query: 283 VRKPAEAERYKLE---RLAEAEKSQLIMQAEAEAASV-RMRGEAEAFAIGARARAEAEQM 338
RK AE E + +L ++ + LI Q + A + +++ E E R AE+
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR---NAEEK 1754
Query: 339 AKKA--EAFQLYQE-------AAQLDMLLEKLPQVAEEISGPLTSANKITL 380
AKKA +A + +E +A L+ + + + Q +++ L A +I L
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Score = 34.3 bits (77), Expect = 0.22
Identities = 40/163 (24%), Positives = 72/163 (44%), Gaps = 22/163 (13%)
Query: 192 AKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIE-VNTRRAQADLAYQLQVAKTKQQIE 250
+KA++ + S L+ + EL + + E + ++ + L Y Q+ K+Q+E
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE 1320
Query: 251 EQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE 310
E+ + A Q A + ++ R E+Y+ E A+AE +++ +A
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLR---------------EQYEEETEAKAELQRVLSKAN 1365
Query: 311 AEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQ 353
+E A R + E +A R E + AKK A Q QEA +
Sbjct: 1366 SEVAQWRTKYETDAI-----QRTEELEEAKKKLA-QRLQEAEE 1402
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 50.4 bits (119), Expect = 3e-06
Identities = 82/330 (24%), Positives = 145/330 (43%), Gaps = 66/330 (20%)
Query: 68 IAQVKIQGQNKEMLAAACQMFLG--KTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQ 125
I +K G+NK M + M L KTE E A++ LE Q H T E+ + Q
Sbjct: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQ-----HSTETELTEALQ 1060
Query: 126 KFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKR 185
K +V ++L N + S TL+ + + +D L KA+ + +K I + A+
Sbjct: 1061 KR-----EVLETELQNAHGELKS-TLRQLQELRDVLQ---KAQLSLEEKYTTIKDLTAE- 1110
Query: 186 DAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAA-----YDIEVNTRRAQADLAY-- 238
+RE K + E Q L E++ A +R++ELK+ A D+ + R + +
Sbjct: 1111 ---LRECKMEIED-KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIK 1166
Query: 239 --------QLQVAKTKQQIEE-----QRVQVQVVERAQQVAVQEQEIARREKELEARVRK 285
+L++ + +QIE Q + Q+ E+ + EQEI++ +KE+E ++
Sbjct: 1167 LEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 1226
Query: 286 PAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQM----AKK 341
E E +M+ + + + + + EA +G R EQ+ +
Sbjct: 1227 MKEMES--------------VMKEQEQYIATQYK---EAIDLGQELRLTREQVQNSHTEL 1269
Query: 342 AEA----FQLYQEAAQLDMLLEKLPQVAEE 367
AEA Q +E +L LE + Q+++E
Sbjct: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKE 1299
Score = 38.1 bits (87), Expect = 0.015
Identities = 34/136 (25%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 233 QADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERY 292
+A+++ Q +V + + EQ Q V+E+ Q + ++E + + +L + ++ AER
Sbjct: 297 EAEVSAQDKVLREAENKLEQS-QKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355
Query: 293 KLERLAEAEK-SQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEA 351
+ E L AE+ S+ Q + + A + +AE + ++ + E LY+
Sbjct: 356 RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYK-- 413
Query: 352 AQLDMLLEKLPQVAEE 367
++L++L EKL Q+ EE
Sbjct: 414 SELEILKEKLRQLKEE 429
Score = 37.7 bits (86), Expect = 0.020
Identities = 39/140 (27%), Positives = 69/140 (49%), Gaps = 14/140 (10%)
Query: 248 QIEEQRVQVQVVERAQQ----VAVQEQEIARREKELEARVRKPAEAERYKLERLAE--AE 301
++ + R +V ++E AQQ V + E++I E E+ A+ + EAE KLE+ + E
Sbjct: 265 ELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAEN-KLEQSQKMVIE 323
Query: 302 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAE----AFQLYQEAAQLDML 357
K Q + +++ E +++ E G RA + + AE AFQ Y++ ++
Sbjct: 324 KEQSLQESKEECIKLKV-DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKK--KVAEK 380
Query: 358 LEKLPQVAEEISGPLTSANK 377
LEK+ E + LT+ K
Sbjct: 381 LEKVQAEEEILERNLTNCEK 400
>gi|38016911 stomatin isoform a [Homo sapiens]
Length = 288
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/183 (21%), Positives = 77/183 (42%), Gaps = 23/183 (12%)
Query: 27 GRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQ 86
G F+LPC ++ + T++ ++ +++ T+ V ISV G+ ++Q A
Sbjct: 80 GLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQN------ATLAV 133
Query: 87 MFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISV 146
+ ++ +A TL R ++ + +I DR++ + + GI V
Sbjct: 134 ANITNADSATRLLAQTTL----RNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKV 189
Query: 147 VSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSE 206
+KD+ Q+Q+ A EAEA R+A + A+ E +++ L E
Sbjct: 190 ERVEIKDV------------KLPVQLQR-AMAAEAEASREARAKVIAAEGEMNASRALKE 236
Query: 207 IEM 209
M
Sbjct: 237 ASM 239
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 48.5 bits (114), Expect = 1e-05
Identities = 67/314 (21%), Positives = 138/314 (43%), Gaps = 59/314 (18%)
Query: 91 KTEAEIAHIALETLEGHQRAIMA-HMTVEEIYKDRQKFSEQVFKVASS-DLVNMGI---- 144
K + E+ A++ E R A + ++ + +DRQ +EQ+ ++S+ +L+ +
Sbjct: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Query: 145 ---SVVSYT-------LKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIRE-AK 193
SV+ T ++ + ++ + G+ R +++ D +AE +RDA R+ A+
Sbjct: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQ--GEVRCLKLELDTERSQAEQERDAAARQLAQ 835
Query: 194 AKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLA---YQLQVAKTKQQIE 250
A+QE +A E +KAA++ EVN R + + +Q ++AK + +E
Sbjct: 836 AEQEGKTA--------------LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
Query: 251 EQRVQVQVVERAQQVAVQEQEIARREKELEA-----RVRKPAEAER-------------- 291
+++++++ + QQ ++ + R E+ +A +++ E ER
Sbjct: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
Query: 292 ----YKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQL 347
+LERL + K Q + + E EA+ A + + A + E+ L
Sbjct: 942 ADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
Query: 348 YQEAAQLDMLLEKL 361
Q+ L +E L
Sbjct: 1002 LQDKMDLQKQVEDL 1015
Score = 44.3 bits (103), Expect = 2e-04
Identities = 76/359 (21%), Positives = 159/359 (44%), Gaps = 53/359 (14%)
Query: 36 QQIQRISLNTLTLNV--KSEKVYTR----HGVPISVTGIAQVKIQGQNKEMLAAACQMFL 89
++ QR++L LTL++ +S+++ + H + T +A+ ++Q +++E+ + Q +
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR-ELQERDQEVKSQREQ--I 1639
Query: 90 GKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSY 149
+ + + H+ + LE + +M ++ +D++ + K+ DL + +S
Sbjct: 1640 EELQRQKEHLT-QDLERRDQELMLQKERIQVLEDQRT---RQTKILEEDLEQIKLS---- 1691
Query: 150 TLKDIHDDQDYLHSLGKARTAQ---VQKDARIGEAEAKRDAG-------IREAKAKQEKV 199
L G+ T Q +Q+ A G+ +K G I K K+ +
Sbjct: 1692 -----------LRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
Query: 200 SAQYLSEIEMAKAQRDYEL----KKAAYDIEVNTRRAQ--ADLAYQLQVAKTKQQIEEQR 253
+++ E++ K Q + +L +K + ++R Q L QLQ A+ + +++EQ
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS 1800
Query: 254 VQVQVVERAQQVAVQEQEIARREKE------LEARVRKPAEAERYKLERLAEAEKSQLIM 307
+Q Q+ E + +A ++QE+ ++E E RV++ A+A + LE+ K +
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER--- 1857
Query: 308 QAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366
E + + R E A+ R E++ A QE A L + + Q E
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Score = 41.2 bits (95), Expect = 0.002
Identities = 62/302 (20%), Positives = 129/302 (42%), Gaps = 21/302 (6%)
Query: 71 VKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQ 130
++ Q Q E A Q L + E I + E + A +E+++++ ++ E
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 131 VFK-VASSDLVNMGISVVSYTLKDIHDD-QDYLHSLGKARTAQVQKDARIGEAEAKRDAG 188
+ + V + + + + L+ + D QD L +A+ ++ + EA+ +
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS-- 781
Query: 189 IREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQ 248
+ E Q +V Q +++ A+ + + +E++T R+QA+ + Q
Sbjct: 782 VIEVTKGQLEVQIQTVTQ-----AKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836
Query: 249 IEEQRVQVQVVERAQQVAVQ------EQEIARREKELEARVRKPAEAERYKLE-RLAEAE 301
+E + ++ + A + V E+E + ++EL A+ + E E+ +LE RL E +
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL-AKALESLEREKMELEMRLKEQQ 895
Query: 302 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKL 361
+QA+ E R +AE+ + E E+++ Q +E A LE+L
Sbjct: 896 TEMEAIQAQREEE----RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951
Query: 362 PQ 363
Q
Sbjct: 952 RQ 953
Score = 40.0 bits (92), Expect = 0.004
Identities = 49/189 (25%), Positives = 87/189 (46%), Gaps = 12/189 (6%)
Query: 171 QVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTR 230
++++D ++ + + + GI + + ++ ++ E+ +A R + AA E ++
Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQLQE--------AQRELKEAARQHRDDLAALQ-EESSS 1000
Query: 231 RAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQE-QEIARREKELEARVRKPAEA 289
Q + Q QV K Q+ Q ++VE+ Q ++E QE R +KELE +
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 290 ERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAE-AEQMAKKAEAFQLY 348
K +RL +++ I Q E A M+ EA+ A+ E Q K+ EA L
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQ-EAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 349 QEAAQLDML 357
QEA L+ L
Sbjct: 1120 QEAQLLEEL 1128
Score = 37.4 bits (85), Expect = 0.026
Identities = 67/296 (22%), Positives = 122/296 (41%), Gaps = 30/296 (10%)
Query: 78 KEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASS 137
+E AA Q+ L TE+++ +A E G+Q A + +Y Q+ V + +
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA--SLYSALQQALGSVCE-SRP 1201
Query: 138 DLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQE 197
+L G S S + + DQ+ SL K A EA A + + K +
Sbjct: 1202 ELSGGGDSAPS--VWGLEPDQNGARSLFKRGPLLTALSA---EAVASALHKLHQDLWKTQ 1256
Query: 198 KVSAQYLSEIE-MAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQV 256
+ +++ + + D E +K+ E+ + Q Q Q K+K + ++ ++
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS---QNQEEKSKWEGKQNSLES 1313
Query: 257 QVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAE-AEAAS 315
+++E + +A + + R E + R A+ ER L +A K L Q E +AA
Sbjct: 1314 ELMELHETMASLQSRLRRAELQ-----RMEAQGER----ELLQAAKENLTAQVEHLQAAV 1364
Query: 316 VRMRGEAEAFAI--------GARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQ 363
V R +A A I + + + E++ + E Q QE +L + K Q
Sbjct: 1365 VEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Score = 36.2 bits (82), Expect = 0.058
Identities = 59/305 (19%), Positives = 124/305 (40%), Gaps = 27/305 (8%)
Query: 70 QVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSE 129
Q + G + + ++ + E +H+ E L Q + A + E SE
Sbjct: 525 QEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE 584
Query: 130 QVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDA-- 187
K +DL + + + D L + +R+ AE R+A
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ 644
Query: 188 -GIREAKAKQEKVSAQYLS-EIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKT 245
+ EA+ ++E + + E ++ KA+ +A +++ + R Q + ++Q +
Sbjct: 645 VDLAEAEKRREALWEKNTHLEAQLQKAE------EAGAELQADLRDIQEEKE-EIQKKLS 697
Query: 246 KQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQL 305
+ + +++ Q+ + Q+ QE+ +AR +E EA VR+ A E RL E+
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE----VRLQAVER--- 750
Query: 306 IMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVA 365
+ + + +++G + A + + EA+Q E + QL++ ++ + Q
Sbjct: 751 ----DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK-----GQLEVQIQTVTQAK 801
Query: 366 EEISG 370
E I G
Sbjct: 802 EVIQG 806
Score = 32.7 bits (73), Expect = 0.65
Identities = 50/227 (22%), Positives = 96/227 (42%), Gaps = 25/227 (11%)
Query: 163 SLGKARTAQVQKDARIGE-AEAKRDAGIREAKAKQEKVSAQYLS-EIEMAKAQRDYELKK 220
+LGKA A K+ + E AE R A + + Q S ++E A ++ E++
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028
Query: 221 AAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELE 280
+ + ++ Q LA + + + +Q+ EQ ++ + +R Q+ +QE++ +E+E E
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQE-REQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 281 --------------ARVRKPAE-------AERYKLERLAEAEKSQLIMQAEAEAASVRMR 319
+K E +R LE L + K+ + + + S+ R
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Query: 320 GEAEAFAIGARAR-AEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVA 365
+ E + A R EA ++ + +A L AQ + L +VA
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVA 2194
>gi|221316744 stomatin-like 3 isoform 2 [Homo sapiens]
Length = 282
Score = 48.1 bits (113), Expect = 1e-05
Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 23/193 (11%)
Query: 27 GRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQ 86
G + VLPCI ++ L T+T N+ +++ TR V V G+ +I A +
Sbjct: 68 GLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYS------AVSAV 121
Query: 87 MFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISV 146
+ +A TL R ++ T+ +I R++ + + + GI V
Sbjct: 122 ANVNDVHQATFLLAQTTL----RNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRV 177
Query: 147 VSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSE 206
+KD+ Q+Q+ + EAEA R+A + A+ E +++ L
Sbjct: 178 ARVEIKDVR------------IPVQLQR-SMAAEAEATREARAKVLAAEGEMNASKSLKS 224
Query: 207 IEMAKAQRDYELK 219
M A+ L+
Sbjct: 225 ASMVLAESPIALQ 237
>gi|21686995 stomatin-like 3 isoform 1 [Homo sapiens]
Length = 291
Score = 48.1 bits (113), Expect = 1e-05
Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 23/193 (11%)
Query: 27 GRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQ 86
G + VLPCI ++ L T+T N+ +++ TR V V G+ +I A +
Sbjct: 77 GLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYS------AVSAV 130
Query: 87 MFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISV 146
+ +A TL R ++ T+ +I R++ + + + GI V
Sbjct: 131 ANVNDVHQATFLLAQTTL----RNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRV 186
Query: 147 VSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSE 206
+KD+ Q+Q+ + EAEA R+A + A+ E +++ L
Sbjct: 187 ARVEIKDVR------------IPVQLQR-SMAAEAEATREARAKVLAAEGEMNASKSLKS 233
Query: 207 IEMAKAQRDYELK 219
M A+ L+
Sbjct: 234 ASMVLAESPIALQ 246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.127 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,286,578
Number of Sequences: 37866
Number of extensions: 457520
Number of successful extensions: 5779
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 548
Number of HSP's that attempted gapping in prelim test: 3188
Number of HSP's gapped (non-prelim): 1731
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.