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Search of human proteins with 48255970
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
(367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 742 0.0
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 482 e-136
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 481 e-136
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 479 e-135
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 478 e-135
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 389 e-108
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 365 e-101
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 316 2e-86
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 316 2e-86
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 315 3e-86
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 315 3e-86
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 312 3e-85
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 312 3e-85
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 311 6e-85
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 311 6e-85
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 311 6e-85
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 307 9e-84
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 307 9e-84
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 289 2e-78
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 289 2e-78
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 285 3e-77
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 278 6e-75
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 258 5e-69
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 258 5e-69
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 258 5e-69
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 248 8e-66
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 243 2e-64
gi|149408126 nemo like kinase [Homo sapiens] 224 9e-59
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 213 3e-55
gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo ... 209 3e-54
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 742 bits (1915), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60
Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120
Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180
Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360
Query: 361 VSKETPL 367
VSKETPL
Sbjct: 361 VSKETPL 367
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 482 bits (1240), Expect = e-136
Identities = 223/347 (64%), Positives = 280/347 (80%)
Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS +
Sbjct: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL +
Sbjct: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV
Sbjct: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH++QL++IM++TGTPPA
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 244
Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307
+ R+ S EA+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+TA +ALA
Sbjct: 245 YLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304
Query: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
H YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP
Sbjct: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 481 bits (1239), Expect = e-136
Identities = 233/347 (67%), Positives = 281/347 (80%), Gaps = 2/347 (0%)
Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
+ GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F
Sbjct: 6 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 65
Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M E E
Sbjct: 66 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 124
Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV
Sbjct: 125 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 184
Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P
Sbjct: 185 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 244
Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307
EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL
Sbjct: 245 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 304
Query: 308 HPYFESLHDTEDEPQVQK-YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
HP+FE D E+E + Q+ +DDS + T+DEWK+ YKE+++F P
Sbjct: 305 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 479 bits (1234), Expect = e-135
Identities = 225/354 (63%), Positives = 284/354 (80%), Gaps = 3/354 (0%)
Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60
MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R
Sbjct: 1 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 57
Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120
PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++
Sbjct: 58 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 117
Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180
K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNEDCEL+ILDFGLARQAD
Sbjct: 118 KCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADE 177
Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+
Sbjct: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 237
Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV
Sbjct: 238 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 297
Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
+A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSFKPP
Sbjct: 298 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPP 351
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 478 bits (1229), Expect = e-135
Identities = 221/347 (63%), Positives = 279/347 (80%)
Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS +
Sbjct: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL +
Sbjct: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV
Sbjct: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244
Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307
E ++++ S+ A+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+TA +ALA
Sbjct: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 304
Query: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
H YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP
Sbjct: 305 HAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 351
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 389 bits (998), Expect = e-108
Identities = 179/276 (64%), Positives = 226/276 (81%)
Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS +
Sbjct: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL +
Sbjct: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV
Sbjct: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244
Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL 283
E ++++ S+ A+NY++ L ++ K +FA++ A+PL
Sbjct: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 365 bits (937), Expect = e-101
Identities = 169/249 (67%), Positives = 207/249 (83%)
Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS +
Sbjct: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL +
Sbjct: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV
Sbjct: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A
Sbjct: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244
Query: 248 EFVQRLQSD 256
E ++++ S+
Sbjct: 245 ELLKKISSE 253
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 316 bits (809), Expect = 2e-86
Identities = 170/374 (45%), Positives = 244/374 (65%), Gaps = 21/374 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+DH+DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294
AEF+++LQ +NY++ P+ F + + + A +LL KMLV+
Sbjct: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
Query: 353 PPRQLGARVSKETP 366
+ G V K+ P
Sbjct: 365 ERSKNG--VVKDQP 376
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 316 bits (809), Expect = 2e-86
Identities = 170/374 (45%), Positives = 244/374 (65%), Gaps = 21/374 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+DH+DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPS 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294
AEF+++LQ +NY++ P+ F + + + A +LL KMLV+
Sbjct: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
Query: 353 PPRQLGARVSKETP 366
+ G V K+ P
Sbjct: 365 ERSKNG--VVKDQP 376
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 315 bits (808), Expect = 3e-86
Identities = 172/374 (45%), Positives = 243/374 (64%), Gaps = 21/374 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G D++DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPS 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294
AEF+++LQ +NY++ P+ F + + + A +LL KMLV+
Sbjct: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
Query: 353 PPRQLGARVSKETP 366
+ G V K+ P
Sbjct: 365 ERSKNG--VVKDQP 376
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 315 bits (808), Expect = 3e-86
Identities = 172/374 (45%), Positives = 243/374 (64%), Gaps = 21/374 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIMAEM+ K LF G D++DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPS 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294
AEF+++LQ +NY++ P+ F + + + A +LL KMLV+
Sbjct: 246 AEFMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ ++
Sbjct: 305 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWE 364
Query: 353 PPRQLGARVSKETP 366
+ G V K+ P
Sbjct: 365 ERSKNG--VVKDQP 376
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 312 bits (800), Expect = 3e-85
Identities = 168/375 (44%), Positives = 241/375 (64%), Gaps = 19/375 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
+ FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A
Sbjct: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L +
Sbjct: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIM EMI G LF G+DH+DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294
EF+++LQ + Y++ P+ F + + + A +LL KMLV+
Sbjct: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ +
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
Query: 353 PPRQLGARVSKETPL 367
+ G + +PL
Sbjct: 365 ERTKNGVIRGQPSPL 379
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 312 bits (800), Expect = 3e-85
Identities = 168/375 (44%), Positives = 241/375 (64%), Gaps = 19/375 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
+ FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A
Sbjct: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L +
Sbjct: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VDIWSVGCIM EMI G LF G+DH+DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294
EF+++LQ + Y++ P+ F + + + A +LL KMLV+
Sbjct: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ +
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
Query: 353 PPRQLGARVSKETPL 367
+ G + +PL
Sbjct: 365 ERTKNGVIRGQPSPL 379
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 311 bits (797), Expect = 6e-85
Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%)
Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70
FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130
AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188
+L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248
R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296
F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D
Sbjct: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
+R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ +
Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
Query: 355 RQLGARVSKETP 366
+ G + +P
Sbjct: 405 TKNGVVKGQPSP 416
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 311 bits (797), Expect = 6e-85
Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%)
Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70
FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130
AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166
Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188
+L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248
R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296
F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D
Sbjct: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
+R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ +
Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404
Query: 355 RQLGARVSKETP 366
+ G + +P
Sbjct: 405 TKNGVVKGQPSP 416
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 311 bits (797), Expect = 6e-85
Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%)
Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70
FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR
Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69
Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130
AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+
Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 128
Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188
+L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248
R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296
F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306
Query: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354
+R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ +
Sbjct: 307 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 366
Query: 355 RQLGARVSKETP 366
+ G + +P
Sbjct: 367 TKNGVVKGQPSP 378
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 307 bits (787), Expect = 9e-84
Identities = 165/375 (44%), Positives = 240/375 (64%), Gaps = 19/375 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
+ FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A
Sbjct: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L +
Sbjct: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G D++DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPC 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294
EF+++LQ + Y++ P+ F + + + A +LL KMLV+
Sbjct: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ +
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
Query: 353 PPRQLGARVSKETPL 367
+ G + +PL
Sbjct: 365 ERTKNGVIRGQPSPL 379
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 307 bits (787), Expect = 9e-84
Identities = 165/375 (44%), Positives = 240/375 (64%), Gaps = 19/375 (5%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
+ FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A
Sbjct: 8 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L +
Sbjct: 68 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
VTR+YRAPEVIL M Y + VD+WSVGCIM EM+ K LF G D++DQ ++++ GTP
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPC 245
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294
EF+++LQ + Y++ P+ F + + + A +LL KMLV+
Sbjct: 246 PEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 304
Query: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352
DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ +
Sbjct: 305 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 364
Query: 353 PPRQLGARVSKETPL 367
+ G + +PL
Sbjct: 365 ERTKNGVIRGQPSPL 379
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 289 bits (740), Expect = 2e-78
Identities = 148/356 (41%), Positives = 223/356 (62%), Gaps = 13/356 (3%)
Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66
A +G + V ++V Y +L +G GAYG VCSA D +VAIKK+ PF+ +
Sbjct: 5 AAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQT 63
Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126
+ +R RE+++L RHEN+IG+ D+ T++ D Y+V M TDL KL+K + L
Sbjct: 64 YCQRTLREIKILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLS 122
Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----- 181
D I + +YQ+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD +
Sbjct: 123 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Query: 182 -MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
+T YV TRWYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+
Sbjct: 183 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
+ G+P E + + + +A+NY+ LP K + + NA A++LL+KML + +R+
Sbjct: 243 ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI 302
Query: 301 TAGEALAHPYFESLHDTEDEPQVQ---KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
+ALAHPY E +D DEP + K+D DD+ + ++ K + ++E F+P
Sbjct: 303 EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQP 356
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 289 bits (740), Expect = 2e-78
Identities = 148/356 (41%), Positives = 223/356 (62%), Gaps = 13/356 (3%)
Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66
A +G + V ++V Y +L +G GAYG VCSA D +VAIKK+ PF+ +
Sbjct: 5 AAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQT 63
Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126
+ +R RE+++L RHEN+IG+ D+ T++ D Y+V M TDL KL+K + L
Sbjct: 64 YCQRTLREIKILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLS 122
Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----- 181
D I + +YQ+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD +
Sbjct: 123 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Query: 182 -MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
+T YV TRWYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+
Sbjct: 183 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
+ G+P E + + + +A+NY+ LP K + + NA A++LL+KML + +R+
Sbjct: 243 ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI 302
Query: 301 TAGEALAHPYFESLHDTEDEPQVQ---KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
+ALAHPY E +D DEP + K+D DD+ + ++ K + ++E F+P
Sbjct: 303 EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQP 356
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 285 bits (730), Expect = 3e-77
Identities = 146/342 (42%), Positives = 218/342 (63%), Gaps = 13/342 (3%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +YQ+L+G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAP 194
L+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254
E++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314
+ +A+NY++ LP K +A + + A++LL++ML + +R+T EALAHPY E
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
Query: 315 HDTEDEPQVQK---YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
+D DEP ++ + DD+ + + K + ++E F+P
Sbjct: 334 YDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQP 373
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 278 bits (711), Expect = 6e-75
Identities = 139/306 (45%), Positives = 201/306 (65%), Gaps = 8/306 (2%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +YQ+L+G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAP 194
L+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254
E++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E + +
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314
+ +A+NY++ LP K +A + + A++LL++ML + +R+T EALAHPY E
Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
Query: 315 HDTEDE 320
+D DE
Sbjct: 334 YDPTDE 339
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 258 bits (660), Expect = 5e-69
Identities = 134/345 (38%), Positives = 206/345 (59%), Gaps = 9/345 (2%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLK 139
+H+N+I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L+
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYR 192
GL+Y+H+A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252
APE++L+ YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312
+ ++ + Y++ LP + + ++ A A++LL +ML + R++A AL HP+
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 313 SLHDTEDEPQ-VQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356
HD +DEP +D +FD T + K E+ F R+
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 393
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 258 bits (660), Expect = 5e-69
Identities = 134/345 (38%), Positives = 206/345 (59%), Gaps = 9/345 (2%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLK 139
+H+N+I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L+
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYR 192
GL+Y+H+A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252
APE++L+ YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312
+ ++ + Y++ LP + + ++ A A++LL +ML + R++A AL HP+
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 313 SLHDTEDEPQ-VQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356
HD +DEP +D +FD T + K E+ F R+
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 393
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 258 bits (660), Expect = 5e-69
Identities = 134/345 (38%), Positives = 206/345 (59%), Gaps = 9/345 (2%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLK 139
+H+N+I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L+
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYR 192
GL+Y+H+A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252
APE++L+ YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312
+ ++ + Y++ LP + + ++ A A++LL +ML + R++A AL HP+
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 313 SLHDTEDEPQ-VQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356
HD +DEP +D +FD T + K E+ F R+
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 393
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 248 bits (632), Expect = 8e-66
Identities = 137/342 (40%), Positives = 196/342 (57%), Gaps = 57/342 (16%)
Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +YQ+L+G
Sbjct: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAP 194
L+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254
E++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI---------------- 257
Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314
LA++LL++ML + +R+T EALAHPY E
Sbjct: 258 ----------------------------LALDLLDRMLTFNPNKRITVEEALAHPYLEQY 289
Query: 315 HDTEDEPQVQK---YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
+D DEP ++ + DD+ + + K + ++E F+P
Sbjct: 290 YDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQP 329
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 243 bits (621), Expect = 2e-64
Identities = 124/226 (54%), Positives = 165/226 (73%), Gaps = 4/226 (1%)
Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68
S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A
Sbjct: 8 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 67
Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128
KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L +
Sbjct: 68 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 126
Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186
R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV
Sbjct: 127 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYV 186
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232
VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+D +
Sbjct: 187 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 224 bits (571), Expect = 9e-59
Identities = 131/359 (36%), Positives = 209/359 (58%), Gaps = 34/359 (9%)
Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90
+P+G GA+G V S D R G +VA+KK+ FQ+ + KR +REL++L +H+NV+ L
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSAL 201
Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149
D+ P +D F + Y+V M +DL K++ + L D ++ +YQ+L+GL+Y+H+AGI
Sbjct: 202 DILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMRYTQ 205
+HRD+KPGNL VN +C LKI DFGLAR + + MT VVT++YRAPE+++ Y+
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSN 320
Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265
+DIWSVGCI AE++ + LF+ + QL I + GTP E R + AK ++
Sbjct: 321 AIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE-AMRTACEGAKAHILRG 379
Query: 266 PELEKK--DFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES---------- 313
P + ++ + A+ AV+LL +MLV D +R++A +ALAHPY +
Sbjct: 380 PHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMC 439
Query: 314 ----------LHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARV 361
++ ++ EP K+DD+F+ ++ + K + ++ +L +Q G RV
Sbjct: 440 KCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILE----QQKGNRV 494
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 213 bits (541), Expect = 3e-55
Identities = 127/346 (36%), Positives = 199/346 (57%), Gaps = 19/346 (5%)
Query: 19 TAWEVRAVYRDL--QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76
T + R V R L + +G GAYG V AVD RTG VAIKK++ F+ + A+R +RE+
Sbjct: 3 TVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREIT 62
Query: 77 LLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED-RIQFLV 134
LL+ H N+I LLDV + D YLV FM TDL +++ L +D ++ +
Sbjct: 63 LLQEFGDHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIF 118
Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--------DSEMTGYV 186
YQ+L+ R++H+ ++HRD KP N+ ++ +C +K+ DFGLAR D +T YV
Sbjct: 119 YQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYV 178
Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
TRWYRAPEV+L+ RYT VD+WS+GCI+ EM+ G+ LF G+ L QL+ I++ P
Sbjct: 179 ATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPS 238
Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEA 305
E + L S + + L ++ ++L + SP A++LL ++LV ++R++A +A
Sbjct: 239 EEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQA 298
Query: 306 LAHPYFESLHDTEDE--PQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349
L HPY + H DE + + + V ++ E++ Y+ +L
Sbjct: 299 LQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
>gi|20986508 mitogen-activated protein kinase 10 isoform 4 [Homo
sapiens]
Length = 277
Score = 209 bits (532), Expect = 3e-54
Identities = 115/274 (41%), Positives = 170/274 (62%), Gaps = 19/274 (6%)
Query: 109 MPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELK 168
M M +L ++++ E L +R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LK
Sbjct: 1 MELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 59
Query: 169 ILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226
ILDFGLAR A + MT YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF
Sbjct: 60 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILF 118
Query: 227 KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------ 280
G D++DQ ++++ GTP EF+++LQ +NY++ P+ F + ++
Sbjct: 119 PGRDYIDQWNKVIEQLGTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADS 177
Query: 281 ------SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDD 332
+ A +LL KMLV+D +R++ +AL HPY +D + P Q YD D+
Sbjct: 178 EHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDE 237
Query: 333 VDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETP 366
+ T++EWK + YKEV++ + + G + +P
Sbjct: 238 REHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSP 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,218,840
Number of Sequences: 37866
Number of extensions: 608954
Number of successful extensions: 3482
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 1281
Number of HSP's gapped (non-prelim): 964
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.