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Search of human proteins with 4759026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759026 RAS protein activator like 1 [Homo sapiens]
(804 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759026 RAS protein activator like 1 [Homo sapiens] 1622 0.0
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 729 0.0
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 674 0.0
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 674 0.0
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 672 0.0
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 620 e-177
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 620 e-177
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 362 e-100
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 305 1e-82
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 137 4e-32
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 137 4e-32
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 110 4e-24
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 110 4e-24
gi|130502162 RAS protein activator like 3 [Homo sapiens] 108 2e-23
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 108 2e-23
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 106 1e-22
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 106 1e-22
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 86 1e-16
gi|28376627 synaptotagmin IX [Homo sapiens] 80 1e-14
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 74 4e-13
gi|211059429 synaptotagmin II [Homo sapiens] 74 4e-13
gi|31543670 synaptotagmin II [Homo sapiens] 74 4e-13
gi|92859638 synaptotagmin V [Homo sapiens] 74 4e-13
gi|238550198 synaptotagmin III [Homo sapiens] 74 5e-13
gi|238550196 synaptotagmin III [Homo sapiens] 74 5e-13
gi|14150054 synaptotagmin III [Homo sapiens] 74 5e-13
gi|4506067 protein kinase C, alpha [Homo sapiens] 73 9e-13
gi|45504376 synaptotagmin VI [Homo sapiens] 73 1e-12
gi|38570146 synaptotagmin VII [Homo sapiens] 72 2e-12
gi|209447073 synaptotagmin I [Homo sapiens] 71 3e-12
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 1622 bits (4199), Expect = 0.0
Identities = 804/804 (100%), Positives = 804/804 (100%)
Query: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH
Sbjct: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
Query: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI
Sbjct: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW
Sbjct: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
Query: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 240
DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE
Sbjct: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAE 240
Query: 241 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 300
EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD
Sbjct: 241 EDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGD 300
Query: 301 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 360
CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM
Sbjct: 301 CRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGM 360
Query: 361 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 420
PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG
Sbjct: 361 PYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLG 420
Query: 421 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILT 480
PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILT
Sbjct: 421 PIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILT 480
Query: 481 PKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRD 540
PKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRD
Sbjct: 481 PKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRD 540
Query: 541 FLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETL 600
FLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETL
Sbjct: 541 FLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETL 600
Query: 601 SFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNEL 660
SFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNEL
Sbjct: 601 SFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNEL 660
Query: 661 NQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPL 720
NQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPL
Sbjct: 661 NQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPL 720
Query: 721 DPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLA 780
DPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLA
Sbjct: 721 DPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLA 780
Query: 781 DLDRAHEEFQQQERGKAALGPLGP 804
DLDRAHEEFQQQERGKAALGPLGP
Sbjct: 781 DLDRAHEEFQQQERGKAALGPLGP 804
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 729 bits (1882), Expect = 0.0
Identities = 388/794 (48%), Positives = 522/794 (65%), Gaps = 19/794 (2%)
Query: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
LP FH +AFYV+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
L +++ + LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-R 238
+E E GA L VE WDWD+V +NDFLG V + L+ + +GWFRL P +
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294
+ GNLG+L+++VRL ++ VLPS YQPL+ LL V QGP + + L+E
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIE 295
Query: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354
E T +CRQD+AT L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKSME F
Sbjct: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESF 355
Query: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414
+K+ GM YLH VL P+I++VFEEKKY+ELDP K+++ +E ++ E S
Sbjct: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
Query: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474
L +LG ++ A+ SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
Query: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534
+PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q
Sbjct: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQG 535
Query: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594
V++++DF+ +LVD++ + R L + V+EG L + + G +FKK Y
Sbjct: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
Query: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654
L+ E LSF+K+P + I +++IRA E+V+E +F HVMQV+ D G T YLQC
Sbjct: 596 LTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQC 655
Query: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714
K VNELNQWLSALRK S N L + HPG FR +W+CC Q E++ GC +T S VTL
Sbjct: 656 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 715
Query: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772
+W+DPLD D EAQ + R LL L R + L T+ G PE +
Sbjct: 716 EWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 769
Query: 773 ARLLEVLADLDRAH 786
ARLL VL DL AH
Sbjct: 770 ARLLRVLQDLREAH 783
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 674 bits (1738), Expect = 0.0
Identities = 368/794 (46%), Positives = 495/794 (62%), Gaps = 65/794 (8%)
Query: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
LP FH +AFYV+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
L +++ + LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLP-FPR 238
+E E GA L VE WDWD+V +NDFLG V + L+ + +GWFRL P +
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294
+ GNLG+L+++VRL ++ VLPS YQPL+ LL V QGP + + L+E
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ-----LIPLIE 295
Query: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354
E T +CRQD+AT L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F
Sbjct: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESF 355
Query: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414
+K+ GM YLH VL P+I++VFEEKKY+ELDP K+++ +E ++ E S
Sbjct: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
Query: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474
L +LG ++ A+ SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
Query: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534
+PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q
Sbjct: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQG 535
Query: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594
V++++DF+ +LVD++ + R L + V+EG L + + G +FKK Y
Sbjct: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
Query: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654
L+ E LSF+K+P
Sbjct: 596 LTTEALSFAKTP----------------------------------------------SS 609
Query: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714
K VNELNQWLSALRK S N L + HPG FR +W+CC Q E++ GC +T S VTL
Sbjct: 610 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 669
Query: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772
+W+DPLD D EAQ +YR LL L R + L T+ G PE +
Sbjct: 670 EWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 723
Query: 773 ARLLEVLADLDRAH 786
ARLL VL DL AH
Sbjct: 724 ARLLRVLQDLREAH 737
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 674 bits (1738), Expect = 0.0
Identities = 368/794 (46%), Positives = 495/794 (62%), Gaps = 65/794 (8%)
Query: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
LP FH +AFYV+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
L +++ + LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLP-FPR 238
+E E GA L VE WDWD+V +NDFLG V + L+ + +GWFRL P +
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294
+ GNLG+L+++VRL ++ VLPS YQPL+ LL V QGP + + L+E
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ-----LIPLIE 295
Query: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354
E T +CRQD+AT L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F
Sbjct: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESF 355
Query: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414
+K+ GM YLH VL P+I++VFEEKKY+ELDP K+++ +E ++ E S
Sbjct: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
Query: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474
L +LG ++ A+ SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
Query: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534
+PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q
Sbjct: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQG 535
Query: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594
V++++DF+ +LVD++ + R L + V+EG L + + G +FKK Y
Sbjct: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
Query: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654
L+ E LSF+K+P
Sbjct: 596 LTTEALSFAKTP----------------------------------------------SS 609
Query: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714
K VNELNQWLSALRK S N L + HPG FR +W+CC Q E++ GC +T S VTL
Sbjct: 610 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 669
Query: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772
+W+DPLD D EAQ +YR LL L R + L T+ G PE +
Sbjct: 670 EWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 723
Query: 773 ARLLEVLADLDRAH 786
ARLL VL DL AH
Sbjct: 724 ARLLRVLQDLREAH 737
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 672 bits (1734), Expect = 0.0
Identities = 368/794 (46%), Positives = 494/794 (62%), Gaps = 65/794 (8%)
Query: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
LP FH +AFYV+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
L +++ + LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLP-FPR 238
+E E GA L VE WDWD+V +NDFLG V + L+ + +GWFRL P +
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294
+ GNLG+L+++VRL ++ VLPS YQPL+ LL V QGP + + L+E
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ-----LIPLIE 295
Query: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354
E T +CRQD+AT L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKSME F
Sbjct: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESF 355
Query: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414
+K+ GM YLH VL P+I++VFEEKKY+ELDP K+++ +E ++ E S
Sbjct: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
Query: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474
L +LG ++ A+ SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
Query: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534
+PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q
Sbjct: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQG 535
Query: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594
V++++DF+ +LVD++ + R L + V+EG L + + G +FKK Y
Sbjct: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
Query: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654
L+ E LSF+K+P
Sbjct: 596 LTTEALSFAKTP----------------------------------------------SS 609
Query: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714
K VNELNQWLSALRK S N L + HPG FR +W+CC Q E++ GC +T S VTL
Sbjct: 610 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 669
Query: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772
+W+DPLD D EAQ + R LL L R + L T+ G PE +
Sbjct: 670 EWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 723
Query: 773 ARLLEVLADLDRAH 786
ARLL VL DL AH
Sbjct: 724 ARLLRVLQDLREAH 737
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 620 bits (1599), Expect = e-177
Identities = 337/722 (46%), Positives = 461/722 (63%), Gaps = 19/722 (2%)
Query: 73 LDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQG 132
+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI L +++ +
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 133 RCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGA 192
LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W+E E GA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 193 PSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-RAEEDSGGNLGAL 250
L VE WDWD+V +NDFLG V + L+ + +GWFRL P ++ GNLG+L
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 251 RVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLEELTLGDCRQDLA 306
+++VRL ++ VLPS YQPL+ LL V QGP + + L+EE T +CRQD+A
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIEETTSTECRQDVA 235
Query: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEV 366
T L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F+K+ GM YLH V
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGV 295
Query: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426
L P+I++VFEEKKY+ELDP K+++ +E ++ E S L +LG ++ A+
Sbjct: 296 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSAL 355
Query: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486
SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF+PAI++PKLF L
Sbjct: 356 SRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHL 415
Query: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLV 546
R++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q V++++DF+ +LV
Sbjct: 416 RERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLV 475
Query: 547 DVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSP 606
D++ + R L + V+EG L + + G +FKK Y L+ E LSF+K+P
Sbjct: 476 DIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP 535
Query: 607 EWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSA 666
+ I +++IRA E+V+E +F HVMQV+ D G T YLQCK VNELNQWLSA
Sbjct: 536 SSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSA 595
Query: 667 LRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEA 726
LRK S N L + HPG FR +W+CC Q E++ GC +T S VTL +W+DPLD D EA
Sbjct: 596 LRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEA 655
Query: 727 QTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDR 784
Q +YR LL L R + L T+ G PE + ARLL VL DL
Sbjct: 656 QLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSLARLLRVLQDLRE 709
Query: 785 AH 786
AH
Sbjct: 710 AH 711
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 2/87 (2%)
Query: 2 AKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHL 61
A++ L V+E R L KD +G+SDP+ V+ T+ V +S P W E + L
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
Query: 62 PLD-FHQLAFYVLDEDTVGHDDIIGKI 87
L D D V +D +GK+
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKV 143
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 620 bits (1599), Expect = e-177
Identities = 337/722 (46%), Positives = 461/722 (63%), Gaps = 19/722 (2%)
Query: 73 LDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQG 132
+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI L +++ +
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 133 RCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGA 192
LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W+E E GA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 193 PSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-RAEEDSGGNLGAL 250
L VE WDWD+V +NDFLG V + L+ + +GWFRL P ++ GNLG+L
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 251 RVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLEELTLGDCRQDLA 306
+++VRL ++ VLPS YQPL+ LL V QGP + + L+EE T +CRQD+A
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIEETTSTECRQDVA 235
Query: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEV 366
T L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F+K+ GM YLH V
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGV 295
Query: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426
L P+I++VFEEKKY+ELDP K+++ +E ++ E S L +LG ++ A+
Sbjct: 296 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSAL 355
Query: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486
SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF+PAI++PKLF L
Sbjct: 356 SRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHL 415
Query: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLV 546
R++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q V++++DF+ +LV
Sbjct: 416 RERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLV 475
Query: 547 DVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSP 606
D++ + R L + V+EG L + + G +FKK Y L+ E LSF+K+P
Sbjct: 476 DIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP 535
Query: 607 EWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSA 666
+ I +++IRA E+V+E +F HVMQV+ D G T YLQCK VNELNQWLSA
Sbjct: 536 SSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSA 595
Query: 667 LRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEA 726
LRK S N L + HPG FR +W+CC Q E++ GC +T S VTL +W+DPLD D EA
Sbjct: 596 LRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEA 655
Query: 727 QTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDR 784
Q +YR LL L R + L T+ G PE + ARLL VL DL
Sbjct: 656 QLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSLARLLRVLQDLRE 709
Query: 785 AH 786
AH
Sbjct: 710 AH 711
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 2/87 (2%)
Query: 2 AKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHL 61
A++ L V+E R L KD +G+SDP+ V+ T+ V +S P W E + L
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
Query: 62 PLD-FHQLAFYVLDEDTVGHDDIIGKI 87
L D D V +D +GK+
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKV 143
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 362 bits (930), Expect = e-100
Identities = 248/755 (32%), Positives = 378/755 (50%), Gaps = 63/755 (8%)
Query: 6 SLNVRVVEGRALPA-KDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLD 64
S+ +++ E + LP+ S D YC V +D E V RT V +SL PF+GE++ +P
Sbjct: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
Query: 65 FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSV 124
F L+FY+ D D D IIGK+++ +E + D+W L VD D+EVQG++ L +
Sbjct: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKY-HNRDTWFQLQHVDADSEVQGKVHLEL 131
Query: 125 QMLEDGQGRCLRCHVLHARDLAPRD---ISGTSDPFARVF----WGSQSLETSTIKKTRF 177
++ E + CH L R + + ++G DP+A V + S++ +T +KT
Sbjct: 132 RLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNN 191
Query: 178 PHWDEVL----------------ELREMPGAPSPLRVELWDWDMVGKND-FLGMVEFSPK 220
P +DEV + E +RV+LW+ + D FLG + K
Sbjct: 192 PQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLK 251
Query: 221 TLQQKPP-KGWFRLLPFPRAEED-SGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV 278
L+Q + W+ L P + +LG+LR+ V ED V S Y PL +LL++S
Sbjct: 252 VLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSA 311
Query: 279 QGPAEEDTASPLALLEELTLGDCR--QDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD 336
E +AS +L E+ CR Q+ A LV+LFL G F+ + EV RT D
Sbjct: 312 D--VEPVSASAAHILGEV----CREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQD 365
Query: 337 PNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRI 396
PNT+FR NSLASK +++ MKL GM YLH LKP I + + K E+DP K
Sbjct: 366 PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK--------- 416
Query: 397 SFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAE 456
L + + E ++ L Y+ + AI S CP M F L +RF +
Sbjct: 417 -----LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QD 469
Query: 457 HQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQL 516
DV+Y A+S F+FLRFFAPAIL+P LF L H DPQTSR+L L++K VQ++G+L +
Sbjct: 470 DPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSK 529
Query: 517 GQG-KELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKR 575
KE +MA + F + + D + +D+ +++ P +++EG+++KR
Sbjct: 530 SASFKESYMATFYEFFNE--QKYADAVKNFLDLISSSGRRDPKSVEQP-IVLKEGFMIKR 586
Query: 576 KEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHV 635
+ + FKKR+ L+ ++ KS Q +SIP+ +I AVE+++E +F++ ++
Sbjct: 587 AQGRKRFGMK-NFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNM 645
Query: 636 MQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCL 695
QV+ + Y+Q N E W+ L K S N +L HP A+ S W CC
Sbjct: 646 FQVIQPE-----RALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCR 700
Query: 696 QAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVY 730
SA GCS + D +D D E + +Y
Sbjct: 701 APSDSAPGCSPCTGGLPANIQLD-IDGDRETERIY 734
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 305 bits (781), Expect = 1e-82
Identities = 234/837 (27%), Positives = 397/837 (47%), Gaps = 79/837 (9%)
Query: 6 SLNVRVVEGR-ALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLD 64
SL ++ E + LP D +C + +D E V RT V +SL PF+ EE+ +P
Sbjct: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
Query: 65 FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSV 124
F L+FYV D++ + D IGK+++ +E + + G ++W +L VD ++EVQG++ L +
Sbjct: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDL-CNHSGKETWFSLQPVDSNSEVQGKVHLEL 157
Query: 125 QMLE--DGQGRCLRCHVLHARDLAPRD-ISGTS-DPFARVFWGSQSL----ETSTIKKTR 176
++ E G + V+H + I+G S DP+A V S +T KKT
Sbjct: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
Query: 177 FPHWDEVL----------------ELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPK 220
P ++E+ ++ E +R++LW+ + ++ FLG ++
Sbjct: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
Query: 221 TLQ-QKPPKGWFRLLPFPRAEEDSG-GNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV 278
L+ + W+ L P + S +LG+LR+ + ED VLPS+ Y PL LL++S
Sbjct: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
Query: 279 QGPAEEDTASPLALLEELTLGDCRQ--DLATKLVKLFLGRGLAGHFLDYLTRREVARTMD 336
+ +AS +L E+ CR D LV+L L F + ++ T D
Sbjct: 338 D--VQPISASAAYILSEI----CRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQD 391
Query: 337 PNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRI 396
NT+FR NSLA++ +++ MK+VG YL LKP++ + + K E+DP K
Sbjct: 392 ANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIK--------- 442
Query: 397 SFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAE 456
L E E + L Y+ + + IV S CP M F L + +RFP
Sbjct: 443 -----LKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDP 497
Query: 457 HQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSI---GNLG 513
H V+Y A+S F+FLRFFA A+++P F LR H D QT R+L L++K +Q++ G+L
Sbjct: 498 H--VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS 555
Query: 514 QQLGQGKELWMAPLHPFLLQ--CVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGY 571
+ KE +M + + V+ FLD + + E+ + + ++EG
Sbjct: 556 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVH-----LKEGE 610
Query: 572 LLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQ 631
+ KR + + + FKKR+ L+ L++ K P ++IPV +I AVE+++E +F
Sbjct: 611 MYKRAQGRTRIGKK-NFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFN 669
Query: 632 LPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARW 691
++ QV+ + Y+Q N E N+W+ L + S N N+L+ HP + + W
Sbjct: 670 KKNMFQVIHTE-----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNW 724
Query: 692 TCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMD 751
CC + + GC + V D +D D E + +Y L L+L+ +E++
Sbjct: 725 LCCQETGENTLGCKPCTAGVP-ADIQIDIDEDRETERIYSLFTL--SLLKLQKMEEACGT 781
Query: 752 TTLEADTGACPE----VLARQRAATARLLE----VLADLDRAHEEFQQQERGKAALG 800
+ P+ + T + ++ ++ LD HE+++++ A G
Sbjct: 782 IAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYG 838
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 137 bits (345), Expect = 4e-32
Identities = 110/416 (26%), Positives = 195/416 (46%), Gaps = 41/416 (9%)
Query: 139 VLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRV 198
VLH + + ++P+ ++ S + + ++ + P W E ++P + +
Sbjct: 597 VLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEI 656
Query: 199 ELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRL---LPFPRAEEDSGGNLGALRVKV 254
L + K+ + + LQ+ WF L +P E G+LRV+
Sbjct: 657 TLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEP------GSLRVRA 710
Query: 255 RLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELT--LGDCRQDLATKLVKL 312
R ++++P + Y EL+++ L ++ L+ G R LA+ L+++
Sbjct: 711 RYSMEKIMPEEEYSEFKELILQK-----------ELHVVYALSHVCGQDRTLLASILLRI 759
Query: 313 FLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVIS 372
FL L L L RE++ + TLFR+ +LAS MEQ+MK ++H LK I
Sbjct: 760 FLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSIL 819
Query: 373 RVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGR 432
++ E K+ EL P K L + + T+L L L +V+ I +
Sbjct: 820 KIMESKQSCELSPSK--------------LEKNEDVNTNLTHLLNILSELVEKIFMASEI 865
Query: 433 CPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHAD 492
PP +R + L + V+ ++P + ++ +SGF+FLR PAIL P++F++
Sbjct: 866 LPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 923
Query: 493 PQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDV 548
P +R+L+L+AK+VQ++ NL + G KE +M ++PF+ R+ FLD L +V
Sbjct: 924 PIAARTLILVAKSVQNLANL-VEFG-AKEPYMEGVNPFIKSNKHRMIMFLDELGNV 977
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 137 bits (345), Expect = 4e-32
Identities = 110/416 (26%), Positives = 195/416 (46%), Gaps = 41/416 (9%)
Query: 139 VLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRV 198
VLH + + ++P+ ++ S + + ++ + P W E ++P + +
Sbjct: 420 VLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEI 479
Query: 199 ELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRL---LPFPRAEEDSGGNLGALRVKV 254
L + K+ + + LQ+ WF L +P E G+LRV+
Sbjct: 480 TLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEP------GSLRVRA 533
Query: 255 RLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELT--LGDCRQDLATKLVKL 312
R ++++P + Y EL+++ L ++ L+ G R LA+ L+++
Sbjct: 534 RYSMEKIMPEEEYSEFKELILQK-----------ELHVVYALSHVCGQDRTLLASILLRI 582
Query: 313 FLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVIS 372
FL L L L RE++ + TLFR+ +LAS MEQ+MK ++H LK I
Sbjct: 583 FLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSIL 642
Query: 373 RVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGR 432
++ E K+ EL P K L + + T+L L L +V+ I +
Sbjct: 643 KIMESKQSCELSPSK--------------LEKNEDVNTNLTHLLNILSELVEKIFMASEI 688
Query: 433 CPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHAD 492
PP +R + L + V+ ++P + ++ +SGF+FLR PAIL P++F++
Sbjct: 689 LPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 746
Query: 493 PQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDV 548
P +R+L+L+AK+VQ++ NL + G KE +M ++PF+ R+ FLD L +V
Sbjct: 747 PIAARTLILVAKSVQNLANL-VEFG-AKEPYMEGVNPFIKSNKHRMIMFLDELGNV 800
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 110 bits (276), Expect = 4e-24
Identities = 108/406 (26%), Positives = 186/406 (45%), Gaps = 48/406 (11%)
Query: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPH--WDEVLELREMPGA 192
LR ++ A+DLAP+ + +L T KT+ + W E E +P
Sbjct: 319 LRLWIIEAKDLAPKK------KYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 372
Query: 193 PSPLRVELWD----WDMVGKNDFLGMVEFSPKTLQQKP-PKGWFRL-LPFPRAEEDSGGN 246
S + V ++ KN+++G+V ++ + + W+ + P P + G +
Sbjct: 373 HS-ITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPS 431
Query: 247 LGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLA 306
+ R+K R +LP + Y+ E + + ++LE + +++LA
Sbjct: 432 I---RIKSRFQTITILPMEQYKEFAEFVTSNY--------TMLCSVLEPVISVRNKEELA 480
Query: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLASKSMEQFMKLVGMPYLHE 365
LV + G A FL L EV R + + L FR N++A+KS+E+++KLVG YLH+
Sbjct: 481 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD 540
Query: 366 VLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDA 425
L I ++E + E+DP K + SE +++L +
Sbjct: 541 ALGEFIKALYESDENCEVDPSKC------------SSSELIDHQSNLKMCCEL---AFCK 585
Query: 426 IVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFD 485
I+ S P ++ F ++ R QD+ IS LFLRF PAI++P LF+
Sbjct: 586 IINSYCVFPRELKEVFASWKQQCLNR----GKQDISERLISASLFLRFLCPAIMSPSLFN 641
Query: 486 LRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFL 531
L ++ D +TSR+L L+AK +Q++ N + KE +MA ++ FL
Sbjct: 642 LMQEYPDDRTSRTLTLIAKVIQNLANFAK--FGNKEEYMAFMNDFL 685
Score = 33.9 bits (76), Expect = 0.62
Identities = 19/101 (18%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 17 LPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDE- 75
+ AKD++ +C + +DD + ART + ++ FWGE + H + ++ +
Sbjct: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDV 383
Query: 76 ---DTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPD 113
++ +G +++ ++T + ++ W +S P+
Sbjct: 384 EKKKKKDKNNYVGLVNIPTASVTG-RQFVEKWYPVSTPTPN 423
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 110 bits (276), Expect = 4e-24
Identities = 108/406 (26%), Positives = 186/406 (45%), Gaps = 48/406 (11%)
Query: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPH--WDEVLELREMPGA 192
LR ++ A+DLAP+ + +L T KT+ + W E E +P
Sbjct: 171 LRLWIIEAKDLAPKK------KYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 224
Query: 193 PSPLRVELWD----WDMVGKNDFLGMVEFSPKTLQQKP-PKGWFRL-LPFPRAEEDSGGN 246
S + V ++ KN+++G+V ++ + + W+ + P P + G +
Sbjct: 225 HS-ITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPS 283
Query: 247 LGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLA 306
+ R+K R +LP + Y+ E + + ++LE + +++LA
Sbjct: 284 I---RIKSRFQTITILPMEQYKEFAEFVTSNY--------TMLCSVLEPVISVRNKEELA 332
Query: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLASKSMEQFMKLVGMPYLHE 365
LV + G A FL L EV R + + L FR N++A+KS+E+++KLVG YLH+
Sbjct: 333 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD 392
Query: 366 VLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDA 425
L I ++E + E+DP K + SE +++L +
Sbjct: 393 ALGEFIKALYESDENCEVDPSKC------------SSSELIDHQSNLKMCCEL---AFCK 437
Query: 426 IVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFD 485
I+ S P ++ F ++ R QD+ IS LFLRF PAI++P LF+
Sbjct: 438 IINSYCVFPRELKEVFASWKQQCLNR----GKQDISERLISASLFLRFLCPAIMSPSLFN 493
Query: 486 LRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFL 531
L ++ D +TSR+L L+AK +Q++ N + KE +MA ++ FL
Sbjct: 494 LMQEYPDDRTSRTLTLIAKVIQNLANFAK--FGNKEEYMAFMNDFL 537
Score = 33.9 bits (76), Expect = 0.62
Identities = 19/101 (18%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 17 LPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDE- 75
+ AKD++ +C + +DD + ART + ++ FWGE + H + ++ +
Sbjct: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDV 235
Query: 76 ---DTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPD 113
++ +G +++ ++T + ++ W +S P+
Sbjct: 236 EKKKKKDKNNYVGLVNIPTASVTG-RQFVEKWYPVSTPTPN 275
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 108 bits (271), Expect = 2e-23
Identities = 96/325 (29%), Positives = 143/325 (44%), Gaps = 38/325 (11%)
Query: 230 WFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASP 289
WF LL P ALR ++R RVLPS+ Y+ L E L A
Sbjct: 403 WFPLLGAPAG--------AALRARIRARRLRVLPSERYKELAEFLTFHY--------ARL 446
Query: 290 LALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLAS 348
LE +++LA +V++ G A + L E+AR L FR N+LA+
Sbjct: 447 CGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLAT 506
Query: 349 KSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMR 408
K+++++MKLV YL E L V+ R+ + E+DP K L E Q R
Sbjct: 507 KAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASE---------LPEHQAR 557
Query: 409 ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGF 468
L + + I+ S P + + F +ER + + +
Sbjct: 558 ------LRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEV----LGPRLVCAS 607
Query: 469 LFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLH 528
LFLR PAIL P LF L H P +R+L L+AK +Q++ N G+ KE +M ++
Sbjct: 608 LFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRA-PFGE-KEAYMGFMN 665
Query: 529 PFLLQCVSRVRDFLDRLVDVDGDEA 553
FL + ++ FLD++ VD D A
Sbjct: 666 SFLEEHGPAMQCFLDQVAMVDVDAA 690
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 108 bits (270), Expect = 2e-23
Identities = 113/444 (25%), Positives = 192/444 (43%), Gaps = 65/444 (14%)
Query: 135 LRCHVLHARDLAPR-----DISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREM 189
L+ ++ AR+L P+ ++ +AR +S T+ W E E +
Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTV------FWGEHFEFNNL 317
Query: 190 PGAPSPLRVELW-DWDMVGKND---FLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGG 245
P A LR+ L+ D D K D ++G+V TL + + + P SGG
Sbjct: 318 P-AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGG 376
Query: 246 -------------------NLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDT 286
A+R+K R +LP + Y+ E + +
Sbjct: 377 MGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYR------- 429
Query: 287 ASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRSNS 345
A+LE ++++A+ LV + G A FL + EV R M+ + +FR N+
Sbjct: 430 -MLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENT 488
Query: 346 LASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEE 405
LA+K++E++M+L+G YL + + I ++E ++ E+DP K +L+E
Sbjct: 489 LATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTAS---------SLAEH 539
Query: 406 QMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAI 465
Q L + +V S P ++ F R ER +D+ I
Sbjct: 540 QANLRMCCELA------LCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLI 589
Query: 466 SGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMA 525
S LFLRF PAI++P LF L ++ D QTSR+L L+AK +Q++ N + KE ++
Sbjct: 590 SASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSK--FTSKEDFLG 647
Query: 526 PLHPFLLQCVSRVRDFLDRLVDVD 549
++ FL ++ FL + ++D
Sbjct: 648 FMNEFLELEWGSMQQFLYEISNLD 671
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 106 bits (264), Expect = 1e-22
Identities = 104/379 (27%), Positives = 169/379 (44%), Gaps = 46/379 (12%)
Query: 174 KTRFPHWDEVLELREMPGAPSPLR---VELW-DWDMVGK---NDFLGMVEFSPKTLQQKP 226
KT W E E +P PLR V L+ + D K N +LG+V ++ +
Sbjct: 126 KTDNVFWGEHFEFHNLP----PLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQ 181
Query: 227 -PKGWFRLL-PFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEE 284
+ W+ ++ P P+ + G +R+K R +LP + Y+ E + G
Sbjct: 182 FVEKWYPVVTPNPKGGKGPGP---MIRIKARYQTITILPMEMYKEFAEHITNHYLGLC-- 236
Query: 285 DTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRS 343
A LE + ++++A+ LV + G FL L EV R D + +FR
Sbjct: 237 ------AALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRE 290
Query: 344 NSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALS 403
N+LA+K++E+++KLVG YL + L I ++E + E+DP K L
Sbjct: 291 NTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAAD---------LP 341
Query: 404 EEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYL 463
E Q G L I+ S P ++ F + R D+
Sbjct: 342 EHQ------GNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR----GRPDISER 391
Query: 464 AISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELW 523
IS LFLRF PAI++P LF+L ++ D +T+R+L L+AK Q++ N + KE +
Sbjct: 392 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK--FGSKEEY 449
Query: 524 MAPLHPFLLQCVSRVRDFL 542
M+ ++ FL + ++ FL
Sbjct: 450 MSFMNQFLEHEWTNMQRFL 468
Score = 31.6 bits (70), Expect = 3.1
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
L + V+E + LPAK C + +DD + ART ++ FWGE + H
Sbjct: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFH 139
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 106 bits (264), Expect = 1e-22
Identities = 104/379 (27%), Positives = 169/379 (44%), Gaps = 46/379 (12%)
Query: 174 KTRFPHWDEVLELREMPGAPSPLR---VELW-DWDMVGK---NDFLGMVEFSPKTLQQKP 226
KT W E E +P PLR V L+ + D K N +LG+V ++ +
Sbjct: 222 KTDNVFWGEHFEFHNLP----PLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQ 277
Query: 227 -PKGWFRLL-PFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEE 284
+ W+ ++ P P+ + G +R+K R +LP + Y+ E + G
Sbjct: 278 FVEKWYPVVTPNPKGGKGPGP---MIRIKARYQTITILPMEMYKEFAEHITNHYLGLC-- 332
Query: 285 DTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRS 343
A LE + ++++A+ LV + G FL L EV R D + +FR
Sbjct: 333 ------AALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRE 386
Query: 344 NSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALS 403
N+LA+K++E+++KLVG YL + L I ++E + E+DP K L
Sbjct: 387 NTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAAD---------LP 437
Query: 404 EEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYL 463
E Q G L I+ S P ++ F + R D+
Sbjct: 438 EHQ------GNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR----GRPDISER 487
Query: 464 AISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELW 523
IS LFLRF PAI++P LF+L ++ D +T+R+L L+AK Q++ N + KE +
Sbjct: 488 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK--FGSKEEY 545
Query: 524 MAPLHPFLLQCVSRVRDFL 542
M+ ++ FL + ++ FL
Sbjct: 546 MSFMNQFLEHEWTNMQRFL 564
Score = 31.6 bits (70), Expect = 3.1
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
L + V+E + LPAK C + +DD + ART ++ FWGE + H
Sbjct: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFH 235
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 85.9 bits (211), Expect = 1e-16
Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 26/242 (10%)
Query: 304 DLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYL 363
+LA LV LF R L L + +EV TLFR NSLASK M K+ G YL
Sbjct: 1238 ELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYL 1297
Query: 364 HEVLKPVISRVFEEKKY----MELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYL 419
++L P++ V + E+DP +++ E + E LL
Sbjct: 1298 QKLLDPLLRIVITSSDWQHVSFEVDPTRLE-------------PSESLEENQRNLLQ-MT 1343
Query: 420 GPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAIL 479
AI+ S PP +R L++ V +RFPQ A+ +FLRF PAI+
Sbjct: 1344 EKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-----SIGAVGSAMFLRFINPAIV 1398
Query: 480 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 539
+P + D+ P+ R L L++K +QSI N + KE M P + F+ R
Sbjct: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIAN---HVLFTKEEHMRPFNDFVKSNFDAAR 1455
Query: 540 DF 541
F
Sbjct: 1456 RF 1457
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 79.7 bits (195), Expect = 1e-14
Identities = 70/245 (28%), Positives = 117/245 (47%), Gaps = 16/245 (6%)
Query: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVHLP-- 62
L V++ + LPAKD SG+SDPY + + D + +T ++L P + E + +P
Sbjct: 237 LIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYN 296
Query: 63 -LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINLSRVDPDAEVQGEI 120
L+ +L F V D D D+IG++ + AD PR W ++ V D GE+
Sbjct: 297 DLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGEL 356
Query: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW-----GSQSLETSTIKKT 175
S+ L GR L ++ AR+L DI+G SDP+ +V + +TST + T
Sbjct: 357 MFSLCYLPTA-GR-LTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNT 414
Query: 176 RFPHWDEVLELREMPGAPSP--LRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRL 233
P ++E + P L + + D+D VG N+ +G+ + + ++ W +
Sbjct: 415 LNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEA-ERLGRDHWSEM 473
Query: 234 LPFPR 238
L +PR
Sbjct: 474 LSYPR 478
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 74.3 bits (181), Expect = 4e-13
Identities = 74/263 (28%), Positives = 106/263 (40%), Gaps = 47/263 (17%)
Query: 304 DLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYL 363
+LA LV LF R L L + +EV TLFR NSLASK M K+ G YL
Sbjct: 1238 ELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYL 1297
Query: 364 HEVLKPVISRVFEEKKY----MELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYL 419
++L P++ V + E+DP +++ E + E LL
Sbjct: 1298 QKLLDPLLRIVITSSDWQHVSFEVDPTRLE-------------PSESLEENQRNLLQ-MT 1343
Query: 420 GPIVDAIVGSVGRCPPAMRLAFKQLHRR---------------------VEERFPQAEHQ 458
AI+ S PP +R L++ V +RFPQ
Sbjct: 1344 EKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQN--- 1400
Query: 459 DVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQ 518
A+ +FLRF PAI++P + D+ P+ R L L++K +QSI N +
Sbjct: 1401 --SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIAN---HVLF 1455
Query: 519 GKELWMAPLHPFLLQCVSRVRDF 541
KE M P + F+ R F
Sbjct: 1456 TKEEHMRPFNDFVKSNFDAARRF 1478
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 74.3 bits (181), Expect = 4e-13
Identities = 66/250 (26%), Positives = 118/250 (47%), Gaps = 19/250 (7%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
+++ L V V++ LPA D+ G+SDPY V + D + T ++L P + E +T
Sbjct: 152 QANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK 211
Query: 61 LP---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVD-PDAEV 116
+P L L + D D DIIG++ + + + I+ W +L + + E
Sbjct: 212 VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG-QPIEEWRDLQGGEKEEPEK 270
Query: 117 QGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGS-----QSLETST 171
G+IC S++ + G+ C +L A++L D+ G SDP+ ++ + +T+
Sbjct: 271 LGDICTSLRYVPTA-GKLTVC-ILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328
Query: 172 IKKTRFPHWDEVLELREMPG---APSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPK 228
KKT P+++E E+P + V + D+D +GKN+ +G + F +
Sbjct: 329 KKKTLNPYFNESFSF-EIPFEQIQKVQVVVTVLDYDKLGKNEAIGKI-FVGSNATGTELR 386
Query: 229 GWFRLLPFPR 238
W +L PR
Sbjct: 387 HWSDMLANPR 396
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 10/127 (7%)
Query: 129 DGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW---GSQSLETSTIKKTRFPHWDEVLE 185
D Q L VL A +L D+ GTSDP+ +VF + ET +KT P ++E
Sbjct: 150 DFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFT 209
Query: 186 LR----EMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLPFPRAE 240
+ E+ G L + ++D+D K+D +G V+ T+ +P + W L + E
Sbjct: 210 FKVPYQELGG--KTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEE 267
Query: 241 EDSGGNL 247
+ G++
Sbjct: 268 PEKLGDI 274
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 74.3 bits (181), Expect = 4e-13
Identities = 66/250 (26%), Positives = 118/250 (47%), Gaps = 19/250 (7%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
+++ L V V++ LPA D+ G+SDPY V + D + T ++L P + E +T
Sbjct: 152 QANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK 211
Query: 61 LP---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVD-PDAEV 116
+P L L + D D DIIG++ + + + I+ W +L + + E
Sbjct: 212 VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG-QPIEEWRDLQGGEKEEPEK 270
Query: 117 QGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGS-----QSLETST 171
G+IC S++ + G+ C +L A++L D+ G SDP+ ++ + +T+
Sbjct: 271 LGDICTSLRYVPTA-GKLTVC-ILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTV 328
Query: 172 IKKTRFPHWDEVLELREMPG---APSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPK 228
KKT P+++E E+P + V + D+D +GKN+ +G + F +
Sbjct: 329 KKKTLNPYFNESFSF-EIPFEQIQKVQVVVTVLDYDKLGKNEAIGKI-FVGSNATGTELR 386
Query: 229 GWFRLLPFPR 238
W +L PR
Sbjct: 387 HWSDMLANPR 396
Score = 44.7 bits (104), Expect = 3e-04
Identities = 36/127 (28%), Positives = 60/127 (47%), Gaps = 10/127 (7%)
Query: 129 DGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW---GSQSLETSTIKKTRFPHWDEVLE 185
D Q L VL A +L D+ GTSDP+ +VF + ET +KT P ++E
Sbjct: 150 DFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFT 209
Query: 186 LR----EMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLPFPRAE 240
+ E+ G L + ++D+D K+D +G V+ T+ +P + W L + E
Sbjct: 210 FKVPYQELGG--KTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEE 267
Query: 241 EDSGGNL 247
+ G++
Sbjct: 268 PEKLGDI 274
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 74.3 bits (181), Expect = 4e-13
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 16/226 (7%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
+S L V +++ L A D+ GSSDPY V + D T ++L P +GE +
Sbjct: 121 QSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFK 180
Query: 61 LP---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVD-PDAEV 116
+P L L V D D +D IG++ + ++ R + +W L + E
Sbjct: 181 VPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLG-RPVQAWRELQAAPREEQEK 239
Query: 117 QGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARV--FWGSQSL--ETSTI 172
G+IC S++ + G+ L VL A++L D+ G SDP+ +V G + + + +TI
Sbjct: 240 LGDICFSLRYVPTA-GK-LTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTI 297
Query: 173 KK-TRFPHWDEVLELREMPGAPSPLRVEL--WDWDMVGKNDFLGMV 215
KK T P+++E ++VEL D+D +GKN+ +G V
Sbjct: 298 KKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRV 343
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 10/127 (7%)
Query: 129 DGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW---GSQSLETSTIKKTRFPHWDEVLE 185
D Q L +L A LA D+ G+SDP+ RV+ + ET ++T PH+ E
Sbjct: 119 DFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFA 178
Query: 186 LR----EMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLPFPRAE 240
+ E+ G L + ++D+D +ND +G V ++ +P + W L PR E
Sbjct: 179 FKVPYVELGG--RVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREE 236
Query: 241 EDSGGNL 247
++ G++
Sbjct: 237 QEKLGDI 243
Score = 44.7 bits (104), Expect = 3e-04
Identities = 32/111 (28%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 4 SSSLNVRVVEGRALPAKDVSGSSDPYC---LVKVDDEVVARTATVWRS-LGPFWGEEYTV 59
+ L V V+E + L DV G SDPY L++ +V + T+ ++ L P++ E ++
Sbjct: 253 AGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSF 312
Query: 60 HLPLDFHQ---LAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINL 107
+P D Q + VLD D +G ++ IG++++ A A G+ W ++
Sbjct: 313 EVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGA---GLRHWADM 360
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 73.9 bits (180), Expect = 5e-13
Identities = 67/248 (27%), Positives = 111/248 (44%), Gaps = 15/248 (6%)
Query: 4 SSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVHL 61
S L VR+++ LPAKD +G SDPY + + D + +T ++L P + E + +
Sbjct: 313 SDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSV 372
Query: 62 P---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINLSRVDPDAEVQ 117
P L +L F V D D D+IG++ L A+ P W ++ +
Sbjct: 373 PLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADL 432
Query: 118 GEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQ-----SLETSTI 172
GE+ S+ L GR L ++ A +L D++G SDP+ + S+ +TS
Sbjct: 433 GELNFSLCYLPTA-GR-LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 173 KKTRFPHWDEVLELREMPGAPS--PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGW 230
K T P ++E L P + L + + D+D +G N+ +G+ P + W
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 231 FRLLPFPR 238
+L PR
Sbjct: 551 AEMLANPR 558
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 73.9 bits (180), Expect = 5e-13
Identities = 67/248 (27%), Positives = 111/248 (44%), Gaps = 15/248 (6%)
Query: 4 SSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVHL 61
S L VR+++ LPAKD +G SDPY + + D + +T ++L P + E + +
Sbjct: 313 SDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSV 372
Query: 62 P---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINLSRVDPDAEVQ 117
P L +L F V D D D+IG++ L A+ P W ++ +
Sbjct: 373 PLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADL 432
Query: 118 GEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQ-----SLETSTI 172
GE+ S+ L GR L ++ A +L D++G SDP+ + S+ +TS
Sbjct: 433 GELNFSLCYLPTA-GR-LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 173 KKTRFPHWDEVLELREMPGAPS--PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGW 230
K T P ++E L P + L + + D+D +G N+ +G+ P + W
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 231 FRLLPFPR 238
+L PR
Sbjct: 551 AEMLANPR 558
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 73.9 bits (180), Expect = 5e-13
Identities = 67/248 (27%), Positives = 111/248 (44%), Gaps = 15/248 (6%)
Query: 4 SSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVHL 61
S L VR+++ LPAKD +G SDPY + + D + +T ++L P + E + +
Sbjct: 313 SDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSV 372
Query: 62 P---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINLSRVDPDAEVQ 117
P L +L F V D D D+IG++ L A+ P W ++ +
Sbjct: 373 PLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADL 432
Query: 118 GEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQ-----SLETSTI 172
GE+ S+ L GR L ++ A +L D++G SDP+ + S+ +TS
Sbjct: 433 GELNFSLCYLPTA-GR-LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIK 490
Query: 173 KKTRFPHWDEVLELREMPGAPS--PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGW 230
K T P ++E L P + L + + D+D +G N+ +G+ P + W
Sbjct: 491 KNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHW 550
Query: 231 FRLLPFPR 238
+L PR
Sbjct: 551 AEMLANPR 558
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 73.2 bits (178), Expect = 9e-13
Identities = 46/158 (29%), Positives = 71/158 (44%), Gaps = 20/158 (12%)
Query: 115 EVQGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW-----GSQSLET 169
E +G I L ++ ++ L V A++L P D +G SDP+ ++ +T
Sbjct: 157 EKRGRIYLKAEVADEK----LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKT 212
Query: 170 STIKKTRFPHWDEVLELREMPGAPSP-LRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPK 228
TI+ T P W+E + P L VE+WDWD +NDF+G + F L + P
Sbjct: 213 KTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPAS 272
Query: 229 GWFRLL----------PFPRAEEDSGGNLGALRVKVRL 256
GW++LL P P +E+ L K +L
Sbjct: 273 GWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKL 310
Score = 39.7 bits (91), Expect = 0.011
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKV----DDEVVARTATVWRSLGPFWGEEYTVHL- 61
L+V V + + L D +G SDPY +K+ +E +T T+ +L P W E +T L
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232
Query: 62 PLD-FHQLAFYVLDEDTVGHDDIIGKIS 88
P D +L+ + D D +D +G +S
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLS 260
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 72.8 bits (177), Expect = 1e-12
Identities = 69/251 (27%), Positives = 115/251 (45%), Gaps = 20/251 (7%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
++ +L VR+++ LPAKD GSSDPY + + D + +T ++L P + E + H
Sbjct: 157 ETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENF--H 214
Query: 61 LPLDFHQLA-----FYVLDEDTVGHDDIIGKISLSREAITAD-PRGIDSWINLSRVDPDA 114
P+ + +LA V D D D+IG++ L +D R W ++ ++
Sbjct: 215 FPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSES 274
Query: 115 EVQGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW-----GSQSLET 169
GEI S+ L GR L V+ R+L DI+G SDP+ +V + +T
Sbjct: 275 VDLGEIMFSLCYLPTA-GR-LTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKT 332
Query: 170 STIKKTRFPHWDEVLELREMPGAPS--PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPP 227
+ K T P ++E + P L + + D+D VG N+ +G+ T +
Sbjct: 333 TIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVG-ITAEGLGR 391
Query: 228 KGWFRLLPFPR 238
W +L +PR
Sbjct: 392 DHWNEMLAYPR 402
Score = 36.6 bits (83), Expect = 0.095
Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 9/94 (9%)
Query: 129 DGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW---GSQSLETSTIKKTRFPHWDE--- 182
D + L +L A DL +D G+SDP+ +++ L+T +KT P +DE
Sbjct: 155 DYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFH 214
Query: 183 -VLELREMPGAPSPLRVELWDWDMVGKNDFLGMV 215
+ E+ A L + ++D+D ++D +G V
Sbjct: 215 FPVPYEEL--ADRKLHLSVFDFDRFSRHDMIGEV 246
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/249 (24%), Positives = 116/249 (46%), Gaps = 17/249 (6%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
+ S+L V++++ + LPAKD SG+SDP+ + + D + T ++L P W E +
Sbjct: 148 QESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFE 207
Query: 61 -LPLD---FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEV 116
P + L VLD D +D IG++S+ + W +L +
Sbjct: 208 GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQ-TFWKDLKPCSDGSGS 266
Query: 117 QGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW-----GSQSLETST 171
+GE+ LS + + + +++ AR+L DI GTSDP+ +V+ + +T T
Sbjct: 267 RGELLLS--LCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVT 324
Query: 172 IKKTRFPHWDE--VLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKG 229
+K+ P ++E ++ + + + + D D + +ND +G + S K+ K
Sbjct: 325 MKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKS-GPGEVKH 383
Query: 230 WFRLLPFPR 238
W ++ PR
Sbjct: 384 WKDMIARPR 392
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 71.2 bits (173), Expect = 3e-12
Identities = 61/227 (26%), Positives = 108/227 (47%), Gaps = 18/227 (7%)
Query: 3 KSSSLNVRVVEGRALPAKDVSGSSDPYCLVKV--DDEVVARTATVWRSLGPFWGEEYTVH 60
+++ L V +++ LPA D+ G+SDPY V + D + T ++L P + E++T
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFK 214
Query: 61 LP---LDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVD-PDAEV 116
+P L L V D D DIIG+ + + + W +L + + E
Sbjct: 215 VPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFG-HVTEEWRDLQSAEKEEQEK 273
Query: 117 QGEICLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGS-----QSLETST 171
G+IC S++ + G+ L +L A++L D+ G SDP+ ++ + +T+
Sbjct: 274 LGDICFSLRYVPTA-GK-LTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTI 331
Query: 172 IKKTRFPHWDEVLELREMPG---APSPLRVELWDWDMVGKNDFLGMV 215
K T P+++E E+P + V + D+D +GKND +G V
Sbjct: 332 KKNTLNPYYNESFSF-EVPFEQIQKVQVVVTVLDYDKIGKNDAIGKV 377
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/103 (28%), Positives = 53/103 (51%), Gaps = 7/103 (6%)
Query: 4 SSSLNVRVVEGRALPAKDVSGSSDPYC---LVKVDDEVVARTATVWRS-LGPFWGEEYTV 59
+ L V ++E + L DV G SDPY L++ + + T+ ++ L P++ E ++
Sbjct: 287 AGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSF 346
Query: 60 HLPLDFHQ---LAFYVLDEDTVGHDDIIGKISLSREAITADPR 99
+P + Q + VLD D +G +D IGK+ + + A+ R
Sbjct: 347 EVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELR 389
Score = 38.5 bits (88), Expect = 0.025
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 129 DGQGRCLRCHVLHARDLAPRDISGTSDPFARVFW---GSQSLETSTIKKTRFPHWDEVLE 185
D Q L ++ A +L D+ GTSDP+ +VF + ET +KT P ++E
Sbjct: 153 DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 186 LR----EMPGAPSPLRVELWDWDMVGKNDFLG 213
+ E+ G L + ++D+D K+D +G
Sbjct: 213 FKVPYSELGG--KTLVMAVYDFDRFSKHDIIG 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,601,725
Number of Sequences: 37866
Number of extensions: 1451208
Number of successful extensions: 3775
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 3167
Number of HSP's gapped (non-prelim): 475
length of query: 804
length of database: 18,247,518
effective HSP length: 110
effective length of query: 694
effective length of database: 14,082,258
effective search space: 9773087052
effective search space used: 9773087052
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.