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Search of human proteins with 4758104
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide
1 [Homo sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1... 1015 0.0
gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide... 349 3e-96
gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide... 275 7e-74
gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens] 242 5e-64
gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide... 174 2e-43
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 80 3e-15
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 79 1e-14
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 79 1e-14
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 76 8e-14
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 74 3e-13
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 74 4e-13
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 72 1e-12
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 71 3e-12
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 68 2e-11
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 68 2e-11
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 60 5e-09
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 60 6e-09
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 60 6e-09
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 59 8e-09
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 59 8e-09
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 58 2e-08
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 58 2e-08
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 58 2e-08
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 58 2e-08
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 58 2e-08
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 58 2e-08
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ... 58 2e-08
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 58 2e-08
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 57 3e-08
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 57 4e-08
>gi|4758104 cytochrome P450, family 7, subfamily B, polypeptide 1
[Homo sapiens]
Length = 506
Score = 1015 bits (2625), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL 60
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL
Sbjct: 1 MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL 60
Query: 61 NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLE 120
NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLE
Sbjct: 61 NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLE 120
Query: 121 KAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL 180
KAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL
Sbjct: 121 KAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL 180
Query: 181 YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKS 240
YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKS
Sbjct: 181 YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKS 240
Query: 241 IREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT 300
IREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT
Sbjct: 241 IREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT 300
Query: 301 MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL 360
MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL
Sbjct: 301 MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL 360
Query: 361 RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIE 420
RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIE
Sbjct: 361 RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIE 420
Query: 421 DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPI 480
DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPI
Sbjct: 421 DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPI 480
Query: 481 GLNYSRLLFGIQYPDSDVLFRYKVKS 506
GLNYSRLLFGIQYPDSDVLFRYKVKS
Sbjct: 481 GLNYSRLLFGIQYPDSDVLFRYKVKS 506
>gi|166295200 cytochrome P450, family 7, subfamily A, polypeptide 1
[Homo sapiens]
Length = 504
Score = 349 bits (896), Expect = 3e-96
Identities = 205/499 (41%), Positives = 299/499 (59%), Gaps = 19/499 (3%)
Query: 21 GLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDT 80
G+A+AA L L L +RR R+ GEPPL G +PYLG L +PL F++ Q++HG
Sbjct: 9 GIAIAACCCLW-LILGIRR-RQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHV 66
Query: 81 FTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAF---SISQLQKN--HDMN 135
FT L GKY+ FI +P Y V+ + K ++ F KAF SI + N ++N
Sbjct: 67 FTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENIN 126
Query: 136 DELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLL---KTTSWDTAELYPFCSSIIFEIT 192
D + LQG +L+ L ESMM+NL+++ P + KT +W T +Y FC ++FE
Sbjct: 127 DTF---IKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG 183
Query: 193 FTTIYGKVIVCDNNKFISELR--DDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFS 250
+ TI+G+ + + + L D+F +FD F LV+ +PI + + REK+ +
Sbjct: 184 YLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR 243
Query: 251 SEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLR 310
E L K + SE+ R + + +DLE HL LWAS ANTIP FW+++ ++R
Sbjct: 244 HENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR 303
Query: 311 HPEAMAAVRDEIDRLLQSTGQKKG-SGFPIHLTREQLDSLICLESSIFEALRLSSYSTTI 369
+PEAM A +E+ R L++ GQK G PI L++ +L+ L L+S I E+LRLSS S I
Sbjct: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363
Query: 370 RFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFI-EDGKKKTTF 428
R +ED TL E G Y +RK D++A++P ++H DPEI+ P F+YDR++ E+GK KTTF
Sbjct: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423
Query: 429 FKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDD--KPIGLNYSR 486
+ G KLK Y MPFG+G + CPGR FA+ EIKQ L+++L+YF+LE+I+ K L+ SR
Sbjct: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483
Query: 487 LLFGIQYPDSDVLFRYKVK 505
GI P +D+ F+YK K
Sbjct: 484 AGLGILPPLNDIEFKYKFK 502
>gi|166362724 cytochrome P450, family 8, subfamily B, polypeptide 1
[Homo sapiens]
Length = 501
Score = 275 bits (703), Expect = 7e-74
Identities = 181/502 (36%), Positives = 280/502 (55%), Gaps = 27/502 (5%)
Query: 21 GLALAAALLLLA--LCLL-VRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQH 77
G L A L+++A LCL + R RRP EPPL KG +P+LG + RK+ F+K ++ +H
Sbjct: 5 GPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKH 64
Query: 78 GDTFTVLLGGKYITFILDPFQYQLVIKN-HKQLSFRVFSNKLLEKAFSISQLQKNHDMND 136
GD FTV LGG+Y TF++DP + ++K+ ++L F ++ KL+ K F +Q +H+M
Sbjct: 65 GDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEM-- 122
Query: 137 ELH-LCYQFLQGKSLDILLESMMQNLKQVF---EPQLLKTTSWDTAELYPFCSSIIFEIT 192
+H + L+G L L E+M+ +L V + L + W L+ FC I+F
Sbjct: 123 -IHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTAG 181
Query: 193 FTTIYGKVIVCDNNKF-ISELRDDFLKFDDKFAYLVSNI--PIELL--GNVKSIREKIIK 247
+ +++G + + EL +F KFD F V ++ P E L G ++ + K++
Sbjct: 182 YLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKMLS 241
Query: 248 CFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYY 307
S++ + W + L + V ++ + LWAS NT PT FWA+ Y
Sbjct: 242 VSHSQEKEGISNW---LGNMLQFLREQGVPSAMQ-DKFNFMMLWASQGNTGPTSFWALLY 297
Query: 308 LLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYST 367
LL+HPEA+ AVR+E ++L + F L L L+S + E LRL + T
Sbjct: 298 LLKHPEAIRAVREEATQVLGEARLETKQSFAFKL--GALQHTPVLDSVVEETLRLRAAPT 355
Query: 368 TIRFVEEDLTLSSETG-DYCVRKGDLVAIFPPV-LHGDPEIFEAPEEFRYDRFIE-DGKK 424
+R V ED TL +G +Y R GD++A+FP + +H DP+I P F+YDRF+ +G +
Sbjct: 356 LLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSR 415
Query: 425 KTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIID-DKPI-GL 482
K FFK GKK+ Y MP+G+G S CPGRFFAL E+K +++++T+FDLE++D D P+ +
Sbjct: 416 KVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHV 475
Query: 483 NYSRLLFGIQYPDSDVLFRYKV 504
+ R FG P DV FRY++
Sbjct: 476 DPQRWGFGTMQPSHDVRFRYRL 497
>gi|13699859 prostaglandin I2 (prostacyclin) synthase [Homo sapiens]
Length = 500
Score = 242 bits (618), Expect = 5e-64
Identities = 170/499 (34%), Positives = 267/499 (53%), Gaps = 21/499 (4%)
Query: 22 LALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTF 81
L L AALLLL L L RRTRRPGEPPL G +P+LG L+ KD F+ ++++HGD F
Sbjct: 7 LGLLAALLLLLL-LSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIF 65
Query: 82 TVLLGGKYITFILDPFQYQLVI-KNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHL 140
T+L+GG+Y+T +LDP Y V+ + +L F ++ L+E+ F + ++ +DE
Sbjct: 66 TILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQ--LPHYSPSDEKAR 123
Query: 141 CYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTS-WDTAELYPFCSSIIFEITFTTIYGK 199
L + L L E+M NL V + S W L F S + + T+YG
Sbjct: 124 MKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGI 183
Query: 200 VIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVK--------SIREKIIKCFSS 251
+ ++ ++ R F L +P G++ S++ ++ K S
Sbjct: 184 EALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSP 243
Query: 252 EKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRH 311
+LA+ S+ +S LE+ V E+++ A L LWA+ N P FW + +LL++
Sbjct: 244 ARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQ-LWATQGNMGPAAFWLLLFLLKN 302
Query: 312 PEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRF 371
PEA+AAVR E++ +L Q L ++ LDS L+S + E+LRL++ R
Sbjct: 303 PEALAAVRGELESILWQAEQPVSQ--TTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE 360
Query: 372 VEEDLTLSSETG-DYCVRKGDLVAIFPPVL-HGDPEIFEAPEEFRYDRFIE-DGKKKTTF 428
V DL + G ++ +R+GD + +FP + DPEI+ PE F+Y+RF+ DG +K F
Sbjct: 361 VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF 420
Query: 429 FKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEII--DDKPIGLNYSR 486
+K GK+LK Y MP+G G + C GR +A+ IKQ + ++L + DLE+I D + + SR
Sbjct: 421 YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR 480
Query: 487 LLFGIQYPDSDVLFRYKVK 505
FG+ P+ DV RY+++
Sbjct: 481 YGFGLMQPEHDVPVRYRIR 499
>gi|32313587 cytochrome P450, family 39, subfamily A, polypeptide 1
[Homo sapiens]
Length = 469
Score = 174 bits (440), Expect = 2e-43
Identities = 130/481 (27%), Positives = 235/481 (48%), Gaps = 37/481 (7%)
Query: 31 LALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYI 90
LAL LL++R + PP IKGW+P++GV K PL F++ + ++G FTV G +
Sbjct: 15 LALFLLLQR-KNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRM 73
Query: 91 TFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELH-LCYQFLQGKS 149
TF+ + + +K+ K++ F + ++ + SI + ++ LH Y L+GK
Sbjct: 74 TFVTEEEGINVFLKS-KKVDFELAVQNIVYRTASIPK-----NVFLALHEKLYIMLKGKM 127
Query: 150 LDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFI 209
+ L L + QL + T +L +++ +T ++ K + N K I
Sbjct: 128 GTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKI 187
Query: 210 SELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSE-------KLAKMQGWSE 262
E F +D+ F Y S +P LL N ++ ++ F K AK +
Sbjct: 188 KEFHQYFQVYDEDFEY-GSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMT- 245
Query: 263 VFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEI 322
+ Q+ D++E E+ + L LWAS++N +P FW + Y+L HP+ A+ + I
Sbjct: 246 LLQATLDIVETETSKENSP--NYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGI 303
Query: 323 DRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSET 382
+ G+ K I ++ + L++L+ ++ + E +RL + R V + + E
Sbjct: 304 SSVFGKAGKDK-----IKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPV----EI 354
Query: 383 GDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPF 442
+Y + GDL+ + P LH +P+ F PE F+ +R+ + +K +F L C+ M F
Sbjct: 355 LNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSF------LDCF-MAF 407
Query: 443 GTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRY 502
G+G +CP R+FAL+E++ ++++L +D ++D P +Y L+ G+ P+ Y
Sbjct: 408 GSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLP-KQSYLHLV-GVPQPEGQCRIEY 465
Query: 503 K 503
K
Sbjct: 466 K 466
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 80.5 bits (197), Expect = 3e-15
Identities = 123/519 (23%), Positives = 212/519 (40%), Gaps = 78/519 (15%)
Query: 22 LALAAALLLLALCL-----LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQ 76
L LA +L+LL L L ++ PG PL P+LG +L+ K F K+
Sbjct: 13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPL-----PFLGNILSYHKGFCMFDMECHKK 67
Query: 77 HGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNK-------LLEKAFSISQLQ 129
+G + G + + I DP + V+ + VF+N+ ++ A SI++ +
Sbjct: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKE---CYSVFTNRRPFGPVGFMKSAISIAEDE 124
Query: 130 KNHDMNDELHLCYQFLQGKSLDILL----ESMMQNLKQVFEPQLLKTTSWDTAELYPFCS 185
+ + L + + K + ++ + +++NL++ E + L
Sbjct: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE-------TGKPVTLKDVFG 177
Query: 186 SIIFEITFTTIYGKVIVCDNNK---FISELRDDFLKFD--DKFAYLVSNIP-----IELL 235
+ ++ +T +G I NN F+ + L+FD D F ++ P +E+L
Sbjct: 178 AYSMDVITSTSFGVNIDSLNNPQDPFVENTKK-LLRFDFLDPFFLSITVFPFLIPILEVL 236
Query: 236 GNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVL------------EKYYVHEDLEIG 283
RE S K K + + R D L E + DLE+
Sbjct: 237 NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELV 296
Query: 284 AHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTR 343
A + F++A T + + MY L HP+ +++EID +L + K + L
Sbjct: 297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN---KAPPTYDTVLQM 353
Query: 344 EQLDSLICLESSIFE-ALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHG 402
E LD ++ +F A+RL R ++D+ E + KG +V I LH
Sbjct: 354 EYLDMVVNETLRLFPIAMRLE------RVCKKDV----EINGMFIPKGVVVMIPSYALHR 403
Query: 403 DPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQL 462
DP+ + PE+F +RF + K + PFG+G C G FALM +K
Sbjct: 404 DPKYWTEPEKFLPERFSKKNKDNIDPY--------IYTPFGSGPRNCIGMRFALMNMKLA 455
Query: 463 LVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFR 501
L+ +L F + + I L S L G+ P+ V+ +
Sbjct: 456 LIRVLQNFSFKPCKETQIPLKLS--LGGLLQPEKPVVLK 492
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 78.6 bits (192), Expect = 1e-14
Identities = 129/520 (24%), Positives = 208/520 (40%), Gaps = 81/520 (15%)
Query: 22 LALAAALLLLALCL-----LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQ 76
L LA +L+LL L L +R PG PL P LG VL+ R+ +F K+
Sbjct: 13 LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL-----PLLGNVLSYRQGLWKFDTECYKK 67
Query: 77 HGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNK-------LLEKAFSISQLQ 129
+G + G + I DP + V+ + VF+N+ ++ A S+++ +
Sbjct: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKE---CYSVFTNRRSLGPVGFMKSAISLAEDE 124
Query: 130 KNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIF 189
+ + L F GK L+ M + Q + L++ + + P IF
Sbjct: 125 EWKRIRSLLSPT--FTSGK-----LKEMFPIIAQ-YGDVLVRNLRREAEKGKPVTLKDIF 176
Query: 190 -----EITFTTIYGKVIVCDNNK---FISELRDDFLKFDDKFAYLVSNI------PIELL 235
++ T +G I NN F+ + FLKF +S I P+
Sbjct: 177 GAYSMDVITGTSFGVNIDSLNNPQDPFVESTKK-FLKFGFLDPLFLSIILFPFLTPVFEA 235
Query: 236 GNVKSIREKIIKCFS-SEKLAKMQGWSEVFQSRQDVL------------EKYYVHEDLEI 282
NV + I S S K ++ + R D L E + DLE+
Sbjct: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295
Query: 283 GAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLT 342
A + F++A T + + +Y L HP+ ++ EID +L + T
Sbjct: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP---------T 346
Query: 343 REQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHG 402
+ + + L+ + E LRL + IR +E E + KG +V I LH
Sbjct: 347 YDAVVQMEYLDMVVNETLRL--FPVAIR-LERTCKKDVEINGVFIPKGSMVVIPTYALHH 403
Query: 403 DPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYL-MPFGTGTSKCPGRFFALMEIKQ 461
DP+ + PEEFR +RF KKK + + Y+ PFGTG C G FALM +K
Sbjct: 404 DPKYWTEPEEFRPERF---SKKKDS-------IDPYIYTPFGTGPRNCIGMRFALMNMKL 453
Query: 462 LLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFR 501
L+ +L F + + I L G+ P+ ++ +
Sbjct: 454 ALIRVLQNFSFKPCKETQIPLKLDTQ--GLLQPEKPIVLK 491
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 78.6 bits (192), Expect = 1e-14
Identities = 107/510 (20%), Positives = 207/510 (40%), Gaps = 85/510 (16%)
Query: 36 LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILD 95
L ++ PG PL P+LG +L + F + +++G+ + + G + + I+D
Sbjct: 32 LFKKLGIPGPTPL-----PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMD 86
Query: 96 PFQYQLVIKNHKQLSFRVFSNKL-------LEKAFSISQLQKNHDMNDELHLCYQFLQGK 148
P + V+ + VF+N++ L+ A S ++ ++ + L + ++ K
Sbjct: 87 PDMIKTVLVKE---CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFK 143
Query: 149 SLDILL----ESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCD 204
+ ++ + ++++L+Q E + L F + ++ T++G +
Sbjct: 144 EMVPIISQCGDMLVRSLRQEAENS-------KSINLKDFFGAYTMDVITGTLFGVNLDSL 196
Query: 205 NNKFISELRDDFLK---------FDDKFAYLVSNIPIE-------------------LLG 236
NN +D FLK F D F L+S P L
Sbjct: 197 NNP-----QDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251
Query: 237 NVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVAN 296
+++ ++E +K ++ Q + S++ K DLE+ A + ++A+
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKAL--SDLELVAQSIIIIFAAYDT 309
Query: 297 TIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSI 356
T T+ + MY L HP+ +++EID +L + +T + L + L+ +
Sbjct: 310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP---------VTYDALVQMEYLDMVV 360
Query: 357 FEALRL-SSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRY 415
E LRL S R ++D+ E + KG V + LH DP+ + PE+F
Sbjct: 361 NETLRLFPVVSRVTRVCKKDI----EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
Query: 416 DRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEII 475
+RF + K ++ +PFG G C G FAL IK ++ L F +
Sbjct: 417 ERFSKKNKDSIDLYR--------YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPC 468
Query: 476 DDKPIGLNYSRLLFGIQYPDSDVLFRYKVK 505
+ I L L I P+ ++ + ++
Sbjct: 469 KETQIPLKLDNL--PILQPEKPIVLKVHLR 496
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 75.9 bits (185), Expect = 8e-14
Identities = 112/502 (22%), Positives = 199/502 (39%), Gaps = 65/502 (12%)
Query: 28 LLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGG 87
L+ LA LV+ PP I +P+LG + K P+ F++ +++G F+ + G
Sbjct: 49 LIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG 108
Query: 88 KYITFILDPFQYQLVIKN----------HKQLSFRVFSNKLLEKAFSISQLQKNHDMNDE 137
K T++L L+ + + +L+ VF + + L++ +
Sbjct: 109 KTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSG 168
Query: 138 LHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTA---ELYPFCSSIIFEITFT 194
L++ + F Q S+ + + K+ FE SW + ++ S +I
Sbjct: 169 LNIAH-FKQHVSI------IEKETKEYFE-------SWGESGEKNVFEALSELIILTASH 214
Query: 195 TIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSN-IPIELLGNVKSIREKIIKCFSSEK 253
++GK I N+ +++L D A+L+ +P+ +I F
Sbjct: 215 CLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAI 274
Query: 254 LAKMQGWSEVFQSRQDVLEKYYVH----EDLEIGAHHLGFLWASVANTIPTMFWAMYYLL 309
+ Q ++ Q +L+ Y D E+ +G L A + T W ++L
Sbjct: 275 QKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLA 334
Query: 310 RHPEAMAAVRDEIDRLLQS---TGQKK--GSGFPIHLTREQLDSLICLESSIFEALRLSS 364
R D+ LQ QK G P LT +QL L L+ I E LRL
Sbjct: 335 R------------DKTLQKKCYLEQKTVCGENLP-PLTYDQLKDLNLLDRCIKETLRL-- 379
Query: 365 YSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKK 424
I + Y + G V + P V + + +F DR+++D
Sbjct: 380 -RPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPA 438
Query: 425 KTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNY 484
G+K +PFG G +C G FA ++IK + +L ++ ++ID +NY
Sbjct: 439 S------GEKFA--YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNY 490
Query: 485 SRLLFGIQYPDSDVLFRYKVKS 506
+ + I P++ V+ RYK +S
Sbjct: 491 TTM---IHTPENPVI-RYKRRS 508
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 73.9 bits (180), Expect = 3e-13
Identities = 107/511 (20%), Positives = 206/511 (40%), Gaps = 86/511 (16%)
Query: 36 LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILD 95
L ++ PG PL P+LG +L + F + +++G+ + + G + + I+D
Sbjct: 32 LFKKLGIPGPTPL-----PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMD 86
Query: 96 PFQYQLVIKNHKQLSFRVFSNKL-------LEKAFSISQLQKNHDMNDELHLCYQFLQGK 148
P + V+ + VF+N++ L+ A S ++ ++ + L + ++ K
Sbjct: 87 PDMIKTVLVKE---CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFK 143
Query: 149 SLDILL----ESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCD 204
+ ++ + ++++L+Q E + L F + ++ T++G +
Sbjct: 144 EMVPIISQCGDMLVRSLRQEAENS-------KSINLKDFFGAYTMDVITGTLFGVNLDSL 196
Query: 205 NNKFISELRDDFLK---------FDDKFAYLVSNIPIE-------------------LLG 236
NN +D FLK F D F L+S P L
Sbjct: 197 NNP-----QDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251
Query: 237 NVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVAN 296
+++ ++E +K ++ Q + S++ K DLE+ A + ++A+
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKAL--SDLELVAQSIIIIFAAYDT 309
Query: 297 TIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSI 356
T T+ + MY L HP+ +++EID +L + +T + L + L+ +
Sbjct: 310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP---------VTYDALVQMEYLDMVV 360
Query: 357 FEALRL-SSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEF-R 414
E LRL S R ++D+ E + KG V + LH DP+ + PE+F
Sbjct: 361 NETLRLFPVVSRVTRVCKKDI----EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
Query: 415 YDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEI 474
RF + K ++ +PFG G C G FAL IK ++ L F +
Sbjct: 417 ESRFSKKNKDSIDLYR--------YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 468
Query: 475 IDDKPIGLNYSRLLFGIQYPDSDVLFRYKVK 505
+ I L L I P+ ++ + ++
Sbjct: 469 CKETQIPLKLDNL--PILQPEKPIVLKVHLR 497
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 73.6 bits (179), Expect = 4e-13
Identities = 60/186 (32%), Positives = 82/186 (44%), Gaps = 21/186 (11%)
Query: 289 FLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDS 348
F++ T + W++Y L +PE V E+D + + + T E L
Sbjct: 326 FMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA--------TVEDLKK 377
Query: 349 LICLESSIFEALRL-SSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIF 407
L LE I E LRL S R V ED E Y V KG I P LH DP F
Sbjct: 378 LRYLECVIKETLRLFPSVPLFARSVSEDC----EVAGYRVLKGTEAVIIPYALHRDPRYF 433
Query: 408 EAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILL 467
PEEF+ +RF + +G+ Y +PF G C G+ FA+ME K +L +L
Sbjct: 434 PNPEEFQPERFFPEN-------AQGRHPYAY-VPFSAGPRNCIGQKFAVMEEKTILSCIL 485
Query: 468 TYFDLE 473
+F +E
Sbjct: 486 RHFWIE 491
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/215 (29%), Positives = 91/215 (42%), Gaps = 39/215 (18%)
Query: 278 EDLEIGAHHLGFLW------------------ASVANTIPTMFWAMYYLLRHPEAMAAVR 319
+DLE GAH FL+ A V T+ WA+Y L RHPE A+
Sbjct: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
Query: 320 DEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRL-SSYSTTIRFVEEDLTL 378
EI L S G S +P + L L L++ + E LRL R ++D+
Sbjct: 345 SEITAAL-SPG---SSAYP---SATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDI-- 395
Query: 379 SSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCY 438
GDY + K LV + DP F P FR R++ +G F
Sbjct: 396 --HVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFAS-------- 445
Query: 439 LMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLE 473
+PFG G C GR A +E++ L +LT+F+++
Sbjct: 446 -LPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 70.9 bits (172), Expect = 3e-12
Identities = 125/510 (24%), Positives = 208/510 (40%), Gaps = 82/510 (16%)
Query: 22 LALAAALLLLALCL-----LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQ 76
L LA +L+LL L L ++ PG PL P+LG L+ RK F K+
Sbjct: 13 LLLAVSLILLYLYGTRTHGLFKKLGIPGPTPL-----PFLGNALSFRKGYWTFDMECYKK 67
Query: 77 HGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNK-------LLEKAFSISQLQ 129
+ + + + + I DP + V+ + VF+N+ ++ A SI++ +
Sbjct: 68 YRKVWGIYDCQQPMLAITDPDMIKTVLVKE---CYSVFTNRRPFGPVGFMKNAISIAEDE 124
Query: 130 KNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIF 189
+ + L F GK L+ M+ + Q + L++ + P +F
Sbjct: 125 EWKRIRSLLSPT--FTSGK-----LKEMVPIIAQ-YGDVLVRNLRREAETGKPVTLKHVF 176
Query: 190 -----EITFTTIYGKVIVCDNNK---FISELRDDFLKFD--DKFAYLVSNIP-----IEL 234
++ +T +G I NN F+ + L+F+ D F + P +E
Sbjct: 177 GAYSMDVITSTSFGVSIDSLNNPQDPFVENTKK-LLRFNPLDPFVLSIKVFPFLTPILEA 235
Query: 235 LGNVKSIREKIIKCFS-SEKLAKMQGWSEVFQSRQDVL------------EKYYVHEDLE 281
L N+ K+I + S K K E + R D L E + DLE
Sbjct: 236 L-NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLE 294
Query: 282 IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL 341
+ A + F++A T + + +Y L HP+ V+ EID +L + P +
Sbjct: 295 LMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAP------PTYD 348
Query: 342 TREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFPPVL 400
T QL+ L+ + E LRL + + R ++D+ E + KG +V I VL
Sbjct: 349 TVLQLE---YLDMVVNETLRLFPVAMRLERVCKKDV----EINGMFIPKGVVVMIPSYVL 401
Query: 401 HGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIK 460
H DP+ + PE+F +RF + K + PFG+G C G FAL+ +K
Sbjct: 402 HHDPKYWTEPEKFLPERFSKKNKDNIDPY--------IYTPFGSGPRNCIGMRFALVNMK 453
Query: 461 QLLVILLTYFDLEIIDDK--PIGLNYSRLL 488
LV +L F + + P+ L + LL
Sbjct: 454 LALVRVLQNFSFKPCKETQIPLKLRFGGLL 483
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 68.2 bits (165), Expect = 2e-11
Identities = 46/197 (23%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 292 ASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLIC 351
A+V T ++ W +Y L R+P+ + EI +L + E L ++
Sbjct: 326 AAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRA---------EDLRNMPY 376
Query: 352 LESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPE 411
L++ + E++RL+ ++ F L ++ G+Y + KG ++ + VL + FE
Sbjct: 377 LKACLKESMRLTP---SVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 433
Query: 412 EFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFD 471
+FR +R++++ +K F +PFG G C GR A +++ L ++ +D
Sbjct: 434 QFRPERWLQEKEKINPFAH---------LPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 484
Query: 472 LEIIDDKPIGLNYSRLL 488
++ D++P+ + +S L
Sbjct: 485 IQATDNEPVEMLHSGTL 501
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 68.2 bits (165), Expect = 2e-11
Identities = 119/495 (24%), Positives = 201/495 (40%), Gaps = 74/495 (14%)
Query: 27 ALLLLALCLLVRRTRR-PGEP--------PLIKGWLPYLGVVLNLRKDPLRFMKTLQKQH 77
ALLLL L L RR PG PL+ G LP+L ++ + F K LQK++
Sbjct: 6 ALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLV-GSLPFLPRHGHMHNN---FFK-LQKKY 60
Query: 78 GDTFTVLLGGKYITFILDPFQY--QLVIKNHKQLSFR-------VFSNKLLEKAFSISQL 128
G ++V +G K T I+ Q +++IK K S R + SN K + +
Sbjct: 61 GPIYSVRMGTK-TTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN--RKGIAFADS 117
Query: 129 QKNHDMNDELHLCYQFLQGKSLDILLESMM-QNLKQVFEPQLLKTTSWDTAEL----YPF 183
+ ++ L + F K D LE ++ Q + + + +L T + + ++ +
Sbjct: 118 GAHWQLHRRLAMA-TFALFKDGDQKLEKIICQEISTLCD--MLATHNGQSIDISFPVFVA 174
Query: 184 CSSIIFEITFTTIYGK------VIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGN 237
+++I I F T Y VI N I L D L + + N +E L +
Sbjct: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKS 234
Query: 238 VKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLE----------IGAHHL 287
IR ++ K + S+ + D L + ++ D + +H+
Sbjct: 235 HVKIRNDLLNKILENYKEKFR--SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292
Query: 288 -----GFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLT 342
A V T + W + +LL +P+ + +EID+ + GF T
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV---------GFSRTPT 343
Query: 343 REQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHG 402
+ L+ LE++I E LRL + + + + S G++ V KG V I LH
Sbjct: 344 ISDRNRLLLLEATIREVLRLRPVAPML--IPHKANVDSSIGEFAVDKGTEVIINLWALHH 401
Query: 403 DPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQL 462
+ + + P++F +RF+ + +PFG G C G A E+ +
Sbjct: 402 NEKEWHQPDQFMPERFLNPAGTQLI------SPSVSYLPFGAGPRSCIGEILARQELFLI 455
Query: 463 LVILLTYFDLEIIDD 477
+ LL FDLE+ DD
Sbjct: 456 MAWLLQRFDLEVPDD 470
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 60.1 bits (144), Expect = 5e-09
Identities = 52/200 (26%), Positives = 84/200 (42%), Gaps = 24/200 (12%)
Query: 287 LGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQL 346
L +A T T+ WA+ Y+ +PE V+ EIDR++ GQ+ P RE
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVI-GQGQQ-----PSTAARE-- 357
Query: 347 DSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEI 406
S+ + I E R+ + V ++T+ + Y + KG ++ LH DP
Sbjct: 358 -SMPYTNAVIHEVQRMGNIIPLN--VPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTE 414
Query: 407 FEAPEEFRYDRFIEDG--KKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLV 464
+ P+ F D F+E+G KK+ F MPF G C G A E+
Sbjct: 415 WATPDTFNPDHFLENGQFKKREAF-----------MPFSIGKRACLGEQLARTELFIFFT 463
Query: 465 ILLTYFDLEIIDDKPIGLNY 484
L+ F +++ + L +
Sbjct: 464 SLMQKFTFRPPNNEKLSLKF 483
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 59.7 bits (143), Expect = 6e-09
Identities = 60/223 (26%), Positives = 95/223 (42%), Gaps = 27/223 (12%)
Query: 281 EIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIH 340
+I A+ L V T T+ W +Y + R+ + +R E+ L + Q +G
Sbjct: 157 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD----- 208
Query: 341 LTREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFPPV 399
L + L++SI E LRL S T+ R++ DL L DY + LV +
Sbjct: 209 -MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR----DYMIPAKTLVQVAIYA 263
Query: 400 LHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEI 459
L +P F PE F R++ K T F G FG G +C GR A +E+
Sbjct: 264 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLG---------FGWGVRQCLGRRIAELEM 314
Query: 460 KQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRY 502
L+ +L F +EI +G ++ +L P+ + F +
Sbjct: 315 TIFLINMLENFRVEIQHLSDVGTTFNLILM----PEKPISFTF 353
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 59.7 bits (143), Expect = 6e-09
Identities = 60/223 (26%), Positives = 95/223 (42%), Gaps = 27/223 (12%)
Query: 281 EIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIH 340
+I A+ L V T T+ W +Y + R+ + +R E+ L + Q +G
Sbjct: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQGD----- 366
Query: 341 LTREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFPPV 399
L + L++SI E LRL S T+ R++ DL L DY + LV +
Sbjct: 367 -MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR----DYMIPAKTLVQVAIYA 421
Query: 400 LHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEI 459
L +P F PE F R++ K T F G FG G +C GR A +E+
Sbjct: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLG---------FGWGVRQCLGRRIAELEM 472
Query: 460 KQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRY 502
L+ +L F +EI +G ++ +L P+ + F +
Sbjct: 473 TIFLINMLENFRVEIQHLSDVGTTFNLILM----PEKPISFTF 511
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 59.3 bits (142), Expect = 8e-09
Identities = 54/187 (28%), Positives = 84/187 (44%), Gaps = 21/187 (11%)
Query: 292 ASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLIC 351
A T T+ + + LL+HPE A V++EID ++ G+ + P R +
Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVI---GRHRS---PCMQDRSHMPYT-- 348
Query: 352 LESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGD-LVAIFPPVLHGDPEIFEAP 410
++ + E R S T V +T ++ +Y + KG ++A+ VLH D E F P
Sbjct: 349 -DAVVHEIQRYSDLVPT--GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE-FPNP 404
Query: 411 EEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYF 470
F F++ K FK+ Y MPF G C G A ME+ L +L F
Sbjct: 405 NIFDPGHFLD----KNGNFKKSD----YFMPFSAGKRICAGEGLARMELFLFLTTILQNF 456
Query: 471 DLEIIDD 477
+L+ +DD
Sbjct: 457 NLKSVDD 463
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 59.3 bits (142), Expect = 8e-09
Identities = 88/362 (24%), Positives = 148/362 (40%), Gaps = 73/362 (20%)
Query: 162 KQVFEPQLLKTTSWDTAELY-----PFC-----SSIIFEITFTTIYGKVIVCDNNKFISE 211
K EP++++ + AE+ PFC S+ + I + +G+ N++F
Sbjct: 192 KLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEF--- 248
Query: 212 LRDDFLKFDDKFAYLVSNIPIELL-----------GNVKSIR--EKIIKCFSSEKLAKMQ 258
L F + + N + L+ G K +R EK I F +K+ K
Sbjct: 249 --KKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFL-KKIIKDH 305
Query: 259 GWSEVFQSRQDVLEKYYVHE------------DLEIGAHHLGFLW-ASVANTIPTMFWAM 305
S ++ QD ++ Y +H D E + +G L+ A T ++ W +
Sbjct: 306 QESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCL 365
Query: 306 YYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSY 365
Y+ +P+ V +EI+R++ G+ LT + + E++I E RL+
Sbjct: 366 LYMSLNPDVQEKVHEEIERVI-------GANRAPSLTDKA--QMPYTEATIMEVQRLTVV 416
Query: 366 STTI--RFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGK 423
E+ L Y + KG L+ +H DP I+E PE+F +RF++D
Sbjct: 417 VPLAIPHMTSENTVLQG----YTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQG 472
Query: 424 ---KKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDD--K 478
KK TF +PFG G C G A ME+ + V L+ F + +D K
Sbjct: 473 QLIKKETF-----------IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKK 521
Query: 479 PI 480
P+
Sbjct: 522 PL 523
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 58.2 bits (139), Expect = 2e-08
Identities = 72/285 (25%), Positives = 123/285 (43%), Gaps = 36/285 (12%)
Query: 206 NKFISELRDDFLKFDDKFAYLVSNIP---IELLGNVKSIR----EKIIKCFSSEKLAKMQ 258
N+ I L +++ + F+ ++ P +LL NV ++ EK+ + S + Q
Sbjct: 202 NENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261
Query: 259 GWSEVFQSRQDVLEKY-----YVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPE 313
+ + F + + EK+ + E LE A L A T T+ +A+ LL+HPE
Sbjct: 262 DFIDCFLMKMEK-EKHNQPSEFTIESLENTAVDL--FGAGTETTSTTLRYALLLLLKHPE 318
Query: 314 AMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVE 373
A V++EI+R++ G+ + D+++ + L S +
Sbjct: 319 VTAKVQEEIERVI---GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--------LP 367
Query: 374 EDLTLSSETGDYCVRKGDLVAI-FPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRG 432
+T + +Y + KG + I VLH + E F PE F F+++G FK+
Sbjct: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE-FPNPEMFDPHHFLDEGGN----FKKS 422
Query: 433 KKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDD 477
K Y MPF G C G A ME+ L +L F+L+ + D
Sbjct: 423 K----YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 19/193 (9%)
Query: 279 DLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFP 338
D +I A F++ T + W +Y+L +HPE R E+ LL+ P
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDRE-------P 367
Query: 339 IHLTREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFP 397
I + + L L L I E+LRL I R +D L + KG + I
Sbjct: 368 IEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPD---GRVIPKGIVCLINI 424
Query: 398 PVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALM 457
+H +P ++ PE + RF ++ K ++ +PF G C G+ FA+
Sbjct: 425 IGIHYNPTVWPDPEVYDPFRFDQENIK--------ERSPLAFIPFSAGPRNCIGQAFAMA 476
Query: 458 EIKQLLVILLTYF 470
E+K +L + L +F
Sbjct: 477 EMKVVLALTLLHF 489
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 19/193 (9%)
Query: 279 DLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFP 338
D +I A F++ T + W +Y+L +HPE R E+ LL+ P
Sbjct: 315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDRE-------P 367
Query: 339 IHLTREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFP 397
I + + L L L I E+LRL I R +D L + KG + I
Sbjct: 368 IEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPD---GRVIPKGIVCLINI 424
Query: 398 PVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALM 457
+H +P ++ PE + RF ++ K ++ +PF G C G+ FA+
Sbjct: 425 IGIHYNPTVWPDPEVYDPFRFDQENIK--------ERSPLAFIPFSAGPRNCIGQAFAMA 476
Query: 458 EIKQLLVILLTYF 470
E+K +L + L +F
Sbjct: 477 EMKVVLALTLLHF 489
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 57.8 bits (138), Expect = 2e-08
Identities = 99/443 (22%), Positives = 173/443 (39%), Gaps = 56/443 (12%)
Query: 78 GDTFTVLLGGKYITFILDPFQYQLVIKN-HKQLSFRVFSNKLLEKAFSISQLQKNHDMND 136
G TFT LLG + + L ++ + +L+ VF + + L++ +
Sbjct: 3 GKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKS 62
Query: 137 ELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTA---ELYPFCSSIIFEITF 193
L++ + F Q S+ + + K+ FE SW + ++ S +I
Sbjct: 63 GLNIAH-FKQHVSI------IEKETKEYFE-------SWGESGEKNVFEALSELIILTAS 108
Query: 194 TTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSN-IPIELLGNVKSIREKIIKCFSSE 252
++GK I N+ +++L D A+L+ +P+ +I F
Sbjct: 109 HCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKA 168
Query: 253 KLAKMQGWSEVFQSRQDVLEKYYVH----EDLEIGAHHLGFLWASVANTIPTMFWAMYYL 308
+ Q ++ Q +L+ Y D E+ +G L A + T W ++L
Sbjct: 169 IQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFL 228
Query: 309 LRHPEAMAAVRDEIDRLLQST---GQKK--GSGFPIHLTREQLDSLICLESSIFEALRLS 363
R D+ LQ QK G P LT +QL L L+ I E LRL
Sbjct: 229 AR------------DKTLQKKCYLEQKTVCGENLP-PLTYDQLKDLNLLDRCIKETLRLR 275
Query: 364 SYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGK 423
I + Y + G V + P V + + +F DR+++D
Sbjct: 276 P---PIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNP 332
Query: 424 KKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLN 483
G+K +PFG G +C G FA ++IK + +L ++ ++ID +N
Sbjct: 333 AS------GEKFA--YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVN 384
Query: 484 YSRLLFGIQYPDSDVLFRYKVKS 506
Y+ + I P++ V+ RYK +S
Sbjct: 385 YTTM---IHTPENPVI-RYKRRS 403
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 57.8 bits (138), Expect = 2e-08
Identities = 57/234 (24%), Positives = 100/234 (42%), Gaps = 28/234 (11%)
Query: 272 EKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQ 331
E+ Y + + + L F A T T+ + + L+++PE + +EIDR++
Sbjct: 281 ERLYTMDGITVTVADLFF--AGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP--- 335
Query: 332 KKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGD 391
S P R+++ + + I + L + + + T + Y + KG
Sbjct: 336 ---SRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN-----LPHEATRDTIFRGYLIPKGT 387
Query: 392 LVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPG 451
+V + D + F PE+F+ + F+ + K K Y PF TG C G
Sbjct: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF--------KYSDYFKPFSTGKRVCAG 439
Query: 452 RFFALMEIKQLLVILLTYFDLE-IIDDKPIGLNYSRLLFGIQYPDSDVLFRYKV 504
A ME+ LL +L +F+L+ ++D K I L+ + FG P RYK+
Sbjct: 440 EGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPP------RYKL 487
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 57.8 bits (138), Expect = 2e-08
Identities = 57/214 (26%), Positives = 90/214 (42%), Gaps = 23/214 (10%)
Query: 282 IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL 341
I A+ + SV T+ + ++ L R+P A+R E S + P
Sbjct: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH-----PQKA 358
Query: 342 TREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSSETGDYCVRKGDLVAIFPPVL 400
T E L L +++ E LRL + R DL L + Y + G LV +F L
Sbjct: 359 TTE----LPLLRAALKETLRLYPVGLFLERVASSDLVLQN----YHIPAGTLVRVFLYSL 410
Query: 401 HGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIK 460
+P +F PE + R+++ RG Y +PFG G +C GR A E+
Sbjct: 411 GRNPALFPRPERYNPQRWLDI---------RGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461
Query: 461 QLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYP 494
LL +L + +E + + I + YS +L +P
Sbjct: 462 LLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFP 495
>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
[Homo sapiens]
Length = 491
Score = 57.8 bits (138), Expect = 2e-08
Identities = 117/506 (23%), Positives = 205/506 (40%), Gaps = 97/506 (19%)
Query: 19 LPGLALAAALLLLAL-CLLVRRTRRP-GEPPLIKGWLPYLGVVLNL-RKDPLRFMKTLQK 75
+ ++ A LLLLAL CLL+ + R G+ P L LG +L L +D L + L K
Sbjct: 1 MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60
Query: 76 QHGDTFTVLLGGKYITFILDPFQY--QLVIKNHKQLSFR----VFSNKLLEKAFSISQLQ 129
++G +TV LG + + +L +Q + ++ ++ S R F N + S
Sbjct: 61 EYGSMYTVHLGPRRVV-VLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSS-- 117
Query: 130 KNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELY-----PF- 183
D + QF S+ IL M K+ E ++L+ S+ AEL PF
Sbjct: 118 -----GDRWKVLRQF----SIQILRNFGMG--KRSIEERILEEGSFLLAELRKTEGEPFD 166
Query: 184 ----CSSIIFEITFTTIYGKVIVCDNNKFISELR---DDFL-------KFDDKFAYLVSN 229
S + I + ++G D+ + ++ +R D+F + D F L+
Sbjct: 167 PTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDW 226
Query: 230 IP---IELLGNVKSIREKI-------------------IKCFSSEKLAKMQGWSEVFQSR 267
+P + N K +R+ I I+CF L KM + +
Sbjct: 227 VPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCF----LTKMA------EEK 276
Query: 268 QDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQ 327
+D L +++ + L + H+L F +T T+ A L+++P+ A V++EID ++
Sbjct: 277 EDPLSHFHM-DTLLMTTHNLLFGGTKTVST--TLHHAFLALMKYPKVQARVQEEIDLVV- 332
Query: 328 STGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCV 387
G+ + D++I + + ++ + +T + + +
Sbjct: 333 --GRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN--------LPHRVTRDTAFRGFLI 382
Query: 388 RKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTS 447
KG V +H DP F P+EF + F++ + FK+ MPF G
Sbjct: 383 PKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQS----FKKSPAF----MPFSAGRR 434
Query: 448 KCPGRFFALMEIKQLLVILLTYFDLE 473
C G A ME+ L +L F L+
Sbjct: 435 LCLGESLARMELFLYLTAILQSFSLQ 460
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 29/198 (14%)
Query: 279 DLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFP 338
D +I A F++ T + W +Y L RHPE R E+ LL+ K+
Sbjct: 315 DEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKE----- 369
Query: 339 IHLTREQLDSLICLESSIFEALRLSSYSTTI-RFVEEDLTLSS----ETGDYCVRKGDLV 393
+ + L L L + E+LRL + I R +D+ L G C+ D++
Sbjct: 370 --IEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLI--DII 425
Query: 394 AI-FPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGR 452
+ P + DPE++ + FR+D G+ F +PF G C G+
Sbjct: 426 GVHHNPTVWPDPEVY---DPFRFDPENSKGRSPLAF-----------IPFSAGPRNCIGQ 471
Query: 453 FFALMEIKQLLVILLTYF 470
FA+ E+K +L ++L +F
Sbjct: 472 AFAMAEMKVVLALMLLHF 489
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 57.4 bits (137), Expect = 3e-08
Identities = 87/422 (20%), Positives = 173/422 (40%), Gaps = 75/422 (17%)
Query: 36 LVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILD 95
L ++ PG PL P+LG +L + F + +++G+ + + G + + I+D
Sbjct: 32 LFKKLGIPGPTPL-----PFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMD 86
Query: 96 PFQYQLVIKNHKQLSFRVFSNKL-------LEKAFSISQLQKNHDMNDELHLCYQFLQGK 148
P + V+ + VF+N++ L+ A S ++ ++ + L + ++ K
Sbjct: 87 PDMIKTVLVKE---CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFK 143
Query: 149 SLDILL----ESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCD 204
+ ++ + ++++L+Q E + L F + ++ T++G +
Sbjct: 144 EMVPIISQCGDMLVRSLRQEAENS-------KSINLKDFFGAYTMDVITGTLFGVNLDSL 196
Query: 205 NNKFISELRDDFLK---------FDDKFAYLVSNIPIE-------------------LLG 236
NN +D FLK F D F L+S P L
Sbjct: 197 NNP-----QDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKN 251
Query: 237 NVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVAN 296
+++ ++E +K ++ Q + S++ K DLE+ A + ++A+
Sbjct: 252 SIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKAL--SDLELVAQSIIIIFAAYDT 309
Query: 297 TIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSI 356
T T+ + MY L HP+ +++EID +L + +T + L + L+ +
Sbjct: 310 TSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP---------VTYDALVQMEYLDMVV 360
Query: 357 FEALRL-SSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRY 415
E LRL S R ++D+ E + KG V + LH DP+ + PE+F
Sbjct: 361 NETLRLFPVVSRVTRVCKKDI----EINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
Query: 416 DR 417
+R
Sbjct: 417 ER 418
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 57.0 bits (136), Expect = 4e-08
Identities = 50/193 (25%), Positives = 81/193 (41%), Gaps = 19/193 (9%)
Query: 279 DLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFP 338
D +I A F++ T + W +Y L RHPE R E+ LL+ K+
Sbjct: 315 DEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKE----- 369
Query: 339 IHLTREQLDSLICLESSIFEALRL-SSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFP 397
+ + L L L + E+LRL T R +D+ L + KG++ I
Sbjct: 370 --IEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR---VIPKGNVCNINI 424
Query: 398 PVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALM 457
+H +P ++ PE + RF + + K+ +PF G C G+ FA+
Sbjct: 425 FAIHHNPSVWPDPEVYDPFRFDPENAQ--------KRSPMAFIPFSAGPRNCIGQKFAMA 476
Query: 458 EIKQLLVILLTYF 470
E+K +L + L F
Sbjct: 477 EMKVVLALTLLRF 489
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.141 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,283,089
Number of Sequences: 37866
Number of extensions: 788294
Number of successful extensions: 2447
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 2286
Number of HSP's gapped (non-prelim): 92
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.