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Search of human proteins with 46909584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46909584 cAMP-dependent protein kinase catalytic subunit
alpha isoform 2 [Homo sapiens]
(343 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 702 0.0
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 691 0.0
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 644 0.0
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 642 0.0
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 598 e-171
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 461 e-130
gi|4826948 protein kinase, X-linked [Homo sapiens] 371 e-103
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 282 3e-76
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 278 7e-75
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 278 7e-75
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 268 5e-72
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 268 7e-72
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 268 7e-72
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 267 9e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 267 9e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 267 9e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 267 9e-72
gi|4502023 AKT2 kinase [Homo sapiens] 266 3e-71
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 265 6e-71
gi|62241015 AKT1 kinase [Homo sapiens] 264 8e-71
gi|62241013 AKT1 kinase [Homo sapiens] 264 8e-71
gi|62241011 AKT1 kinase [Homo sapiens] 264 8e-71
gi|5453974 protein kinase N2 [Homo sapiens] 251 9e-67
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 250 1e-66
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 250 1e-66
gi|28557781 protein kinase C, eta [Homo sapiens] 249 2e-66
gi|4885563 protein kinase C, epsilon [Homo sapiens] 241 5e-64
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 241 5e-64
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 239 2e-63
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 239 2e-63
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 702 bits (1811), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MASNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN 60
MASNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN
Sbjct: 1 MASNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGN 60
Query: 61 HYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGE 120
HYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGE
Sbjct: 61 HYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGE 120
Query: 121 MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF 180
MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF
Sbjct: 121 MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF 180
Query: 181 AKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 240
AKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY
Sbjct: 181 AKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 240
Query: 241 EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 300
EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ
Sbjct: 241 EKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQ 300
Query: 301 RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Sbjct: 301 RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 691 bits (1782), Expect = 0.0
Identities = 337/341 (98%), Positives = 337/341 (98%)
Query: 3 SNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 62
S VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY
Sbjct: 11 SEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 70
Query: 63 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 122
AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 130
Query: 123 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 182
SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 190
Query: 183 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 242
RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK
Sbjct: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
Query: 243 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 302
IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK
Sbjct: 251 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 310
Query: 303 VEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
VEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Sbjct: 311 VEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 644 bits (1661), Expect = 0.0
Identities = 314/341 (92%), Positives = 323/341 (94%)
Query: 3 SNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 62
S VKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +Y
Sbjct: 11 SEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY 70
Query: 63 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 122
AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMF
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 123 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 182
SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAK
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK 190
Query: 183 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 242
RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK
Sbjct: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
Query: 243 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRK 302
IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFATTDWIAIYQRK
Sbjct: 251 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRK 310
Query: 303 VEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
VEAPFIPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 311 VEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 642 bits (1656), Expect = 0.0
Identities = 312/336 (92%), Positives = 322/336 (95%)
Query: 8 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKIL 67
+KEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +YAMKIL
Sbjct: 63 MKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKIL 122
Query: 68 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR 127
DKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMFSHLRR
Sbjct: 123 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRR 182
Query: 128 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 187
IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAKRVKGR
Sbjct: 183 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGR 242
Query: 188 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 247
TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK
Sbjct: 243 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 302
Query: 248 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 307
VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGV+DIK HKWFATTDWIAIYQRKVEAPF
Sbjct: 303 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPF 362
Query: 308 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
IPKF+G GDTSNFDDYEEE+IRVSI EKC KEF EF
Sbjct: 363 IPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 598 bits (1541), Expect = e-171
Identities = 283/336 (84%), Positives = 313/336 (93%)
Query: 8 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKIL 67
V EFLAKA+ DFL +W +PAQNTA DQFER++TLG GSFGRVMLV+H+ETG HYAMKIL
Sbjct: 16 VNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKIL 75
Query: 68 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR 127
+KQKVVK+KQ+EH LNEKRILQA++FPFLVKL+FSFKDNS LY+VMEYVPGGEMFS L+R
Sbjct: 76 NKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQR 135
Query: 128 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 187
+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLIDQQGY+QVTDFGFAKRVKGR
Sbjct: 136 VGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGR 195
Query: 188 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 247
TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+ADQPIQIYEKIVSG+
Sbjct: 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR 255
Query: 248 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 307
VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIKNHKWFATT WIAIY++KVEAPF
Sbjct: 256 VRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPF 315
Query: 308 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
IPK+ GPGD SNFDDYEEEE+R+SINEKC KEFSEF
Sbjct: 316 IPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 461 bits (1186), Expect = e-130
Identities = 226/245 (92%), Positives = 232/245 (94%)
Query: 3 SNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 62
S VKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T +Y
Sbjct: 11 SEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY 70
Query: 63 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 122
AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMF
Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
Query: 123 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 182
SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAK
Sbjct: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK 190
Query: 183 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 242
RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK
Sbjct: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
Query: 243 IVSGK 247
IVSGK
Sbjct: 251 IVSGK 255
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 371 bits (953), Expect = e-103
Identities = 165/303 (54%), Positives = 228/303 (75%)
Query: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
SP L F+ + T+GTG+FGRV LVK K + +A+K++ V++LKQ +H NE
Sbjct: 38 SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
Query: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
K +L+ V+ PFL++L +++ D LYM+MEYVPGGE+FS+LR GRFS FY+A+I+
Sbjct: 98 KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
Query: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 204
EYLHS +++YRDLKPEN+L+D+ G+I++TDFGFAK++ RTWTLCGTPEYLAPE+I
Sbjct: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
Query: 205 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRN 264
SKG+ +AVDWWALG+LI+EM +G+PPFF D P IY+KI++GK+ FP H +KDL++
Sbjct: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
Query: 265 LLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE 324
LL VD T+R GN+KNG ND+K+H+WF + DW A+ QRK++ P +PK G GDTSNF+ Y
Sbjct: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
Query: 325 EEE 327
E +
Sbjct: 338 END 340
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 282 bits (722), Expect = 3e-76
Identities = 144/307 (46%), Positives = 200/307 (65%), Gaps = 10/307 (3%)
Query: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
SP QN E I TLG G FGRV LVK K +AMK + K+ +V KQ EH +E
Sbjct: 448 SPFQN------LEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSE 501
Query: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
KRIL+ + PF+VKL +FKDN +YM++E GGE++S LR G F EP ++F A +
Sbjct: 502 KRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVT 561
Query: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEI 202
F+YLH L +IYRDLKPENL++D +GY+++ DFGFAK++ +TWT CGTPEY+APE+
Sbjct: 562 EAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEV 621
Query: 203 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKD 260
IL+KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G K+ FP + +D
Sbjct: 622 ILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPED 681
Query: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
L+R L + + T+R GNLKNG+NDIK H+W +W + R + +P + KGP D S F
Sbjct: 682 LIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYF 741
Query: 321 DDYEEEE 327
D Y E+
Sbjct: 742 DKYPPEK 748
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 278 bits (710), Expect = 7e-75
Identities = 142/312 (45%), Positives = 203/312 (65%), Gaps = 7/312 (2%)
Query: 22 KWESPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQI 78
K+E+ A A+L F I TLG G FGRV LV+ K E +AMKIL K+ +V +Q
Sbjct: 344 KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQ 403
Query: 79 EHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 138
EH +EK+I+Q + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RF
Sbjct: 404 EHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRF 463
Query: 139 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPE 196
Y A +V F YLHS +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPE
Sbjct: 464 YTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPE 523
Query: 197 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHF 254
Y+APEIIL+KG++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP
Sbjct: 524 YVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKI 583
Query: 255 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 314
+ + +L++ L + + ++R GNLKNGV DI+ HKWF +W + + + P IP P
Sbjct: 584 AKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASP 643
Query: 315 GDTSNFDDYEEE 326
DTSNFD + E+
Sbjct: 644 TDTSNFDSFPED 655
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 278 bits (710), Expect = 7e-75
Identities = 142/312 (45%), Positives = 203/312 (65%), Gaps = 7/312 (2%)
Query: 22 KWESPAQNTAHL--DQFERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQI 78
K+E+ A A+L F I TLG G FGRV LV+ K E +AMKIL K+ +V +Q
Sbjct: 359 KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQ 418
Query: 79 EHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF 138
EH +EK+I+Q + F+V+L +FKD+ LYM+ME GGE+++ LR G F + RF
Sbjct: 419 EHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRF 478
Query: 139 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPE 196
Y A +V F YLHS +IYRDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPE
Sbjct: 479 YTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPE 538
Query: 197 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHF 254
Y+APEIIL+KG++ + D+W+LG+L+YE+ G PPF P++ Y I+ G + FP
Sbjct: 539 YVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKI 598
Query: 255 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 314
+ + +L++ L + + ++R GNLKNGV DI+ HKWF +W + + + P IP P
Sbjct: 599 AKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASP 658
Query: 315 GDTSNFDDYEEE 326
DTSNFD + E+
Sbjct: 659 TDTSNFDSFPED 670
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 268 bits (685), Expect = 5e-72
Identities = 137/327 (41%), Positives = 196/327 (59%), Gaps = 8/327 (2%)
Query: 18 DFLKKWESPAQNTAH----LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVV 73
D + + E A T H ++ F+ +K LG G+FG+V+LV+ K +G +YAMKIL K+ ++
Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII 185
Query: 74 KLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 133
++ HTL E R+L+ PFL L++SF+ L VMEYV GGE+F HL R FSE
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 134 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWT 190
RFY A+IV +YLHS ++YRDLK ENL++D+ G+I++TDFG K T
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 191 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF 250
CGTPEYLAPE++ Y +AVDWW LGV++YEM G PF+ +++E I+ ++F
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 251 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 310
P SSD K LL LL D KR G + +I H +F+ +W +Y +K+ PF P+
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 311 FKGPGDTSNFD-DYEEEEIRVSINEKC 336
DT FD ++ + I ++ EKC
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPPEKC 452
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 268 bits (684), Expect = 7e-72
Identities = 134/311 (43%), Positives = 198/311 (63%), Gaps = 6/311 (1%)
Query: 27 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 86
A A F+ +K +G G++G+V+L K K G YA+K+L K+ ++K K+ H + E+
Sbjct: 26 ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 85
Query: 87 IL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 145
+L + V PFLV L +SF+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 86 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 145
Query: 146 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEI 202
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAPE+
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEV 205
Query: 203 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 262
+ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + DLL
Sbjct: 206 LRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLL 265
Query: 263 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD- 321
++LL D +R G+ K +IKNH +F+ +W +Y +++ PF P GP D +FD
Sbjct: 266 QSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
Query: 322 DYEEEEIRVSI 332
++ +E + SI
Sbjct: 325 EFTQEAVSKSI 335
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 268 bits (684), Expect = 7e-72
Identities = 134/311 (43%), Positives = 198/311 (63%), Gaps = 6/311 (1%)
Query: 27 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 86
A A F+ +K +G G++G+V+L K K G YA+K+L K+ ++K K+ H + E+
Sbjct: 86 ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 145
Query: 87 IL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 145
+L + V PFLV L +SF+ LY V++YV GGE+F HL+R RF EP ARFYAA++
Sbjct: 146 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 205
Query: 146 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEI 202
YLHSL++IYRDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLAPE+
Sbjct: 206 AIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEV 265
Query: 203 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 262
+ + Y++AVDWW LG ++YEM G PPF++ Q+YE I+ ++ P + DLL
Sbjct: 266 LRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLL 325
Query: 263 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD- 321
++LL D +R G+ K +IKNH +F+ +W +Y +++ PF P GP D +FD
Sbjct: 326 QSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
Query: 322 DYEEEEIRVSI 332
++ +E + SI
Sbjct: 385 EFTQEAVSKSI 395
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 267 bits (683), Expect = 9e-72
Identities = 134/315 (42%), Positives = 200/315 (63%), Gaps = 7/315 (2%)
Query: 26 PAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
P+ N A F +K +G GSFG+V+L +HK YA+K+L K+ ++K K+ +H ++E
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 146
Query: 85 KRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 143
+ +L + V PFLV L FSF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 147 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 206
Query: 144 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 200
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 207 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 266
Query: 201 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 260
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 267 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 326
Query: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +F
Sbjct: 327 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
Query: 321 D-DYEEEEIRVSINE 334
D ++ EE + SI +
Sbjct: 386 DPEFTEEPVPNSIGK 400
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 267 bits (683), Expect = 9e-72
Identities = 134/315 (42%), Positives = 200/315 (63%), Gaps = 7/315 (2%)
Query: 26 PAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
P+ N A F +K +G GSFG+V+L +HK YA+K+L K+ ++K K+ +H ++E
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 160
Query: 85 KRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 143
+ +L + V PFLV L FSF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 161 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 220
Query: 144 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 200
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 221 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 280
Query: 201 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 260
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 281 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 340
Query: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +F
Sbjct: 341 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 321 D-DYEEEEIRVSINE 334
D ++ EE + SI +
Sbjct: 400 DPEFTEEPVPNSIGK 414
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 267 bits (683), Expect = 9e-72
Identities = 134/315 (42%), Positives = 200/315 (63%), Gaps = 7/315 (2%)
Query: 26 PAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
P+ N A F +K +G GSFG+V+L +HK YA+K+L K+ ++K K+ +H ++E
Sbjct: 115 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 174
Query: 85 KRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 143
+ +L + V PFLV L FSF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 175 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 234
Query: 144 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 200
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 235 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 294
Query: 201 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 260
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 295 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 354
Query: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +F
Sbjct: 355 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
Query: 321 D-DYEEEEIRVSINE 334
D ++ EE + SI +
Sbjct: 414 DPEFTEEPVPNSIGK 428
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 267 bits (683), Expect = 9e-72
Identities = 134/315 (42%), Positives = 200/315 (63%), Gaps = 7/315 (2%)
Query: 26 PAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
P+ N A F +K +G GSFG+V+L +HK YA+K+L K+ ++K K+ +H ++E
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 241
Query: 85 KRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 143
+ +L + V PFLV L FSF+ LY V++Y+ GGE+F HL+R F EP ARFYAA+I
Sbjct: 242 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 301
Query: 144 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 200
YLHSL+++YRDLKPEN+L+D QG+I +TDFG K T T CGTPEYLAP
Sbjct: 302 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 361
Query: 201 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKD 260
E++ + Y++ VDWW LG ++YEM G PPF++ ++Y+ I++ ++ + ++ +
Sbjct: 362 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 421
Query: 261 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 320
LL LLQ D TKR G K+ +IK+H +F+ +W + +K+ PF P GP D +F
Sbjct: 422 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 321 D-DYEEEEIRVSINE 334
D ++ EE + SI +
Sbjct: 481 DPEFTEEPVPNSIGK 495
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 266 bits (679), Expect = 3e-71
Identities = 130/301 (43%), Positives = 190/301 (63%), Gaps = 3/301 (0%)
Query: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
S A+ ++ F+ +K LG G+FG+V+LV+ K TG +YAMKIL K+ ++ ++ HT+ E
Sbjct: 141 SKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE 200
Query: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
R+LQ PFL L+++F+ + L VMEY GGE+F HL R F+E ARFY A+IV
Sbjct: 201 SRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260
Query: 145 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPE 201
EYLHS D++YRD+K ENL++D+ G+I++TDFG K G T T CGTPEYLAPE
Sbjct: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE 320
Query: 202 IILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDL 261
++ Y +AVDWW LGV++YEM G PF+ +++E I+ ++RFP S + K L
Sbjct: 321 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSL 380
Query: 262 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 321
L LL+ D +R G + ++ H++F + +W + Q+K+ PF P+ DT FD
Sbjct: 381 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440
Query: 322 D 322
D
Sbjct: 441 D 441
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 265 bits (676), Expect = 6e-71
Identities = 136/326 (41%), Positives = 195/326 (59%), Gaps = 8/326 (2%)
Query: 18 DFLKKWESPAQNTAH----LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVV 73
D + + E A T H ++ F+ +K LG G+FG+V+LV+ K +G +YAMKIL K+ ++
Sbjct: 126 DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII 185
Query: 74 KLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 133
++ HTL E R+L+ PFL L++SF+ L VMEYV GGE+F HL R FSE
Sbjct: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
Query: 134 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWT 190
RFY A+IV +YLHS ++YRDLK ENL++D+ G+I++TDFG K T
Sbjct: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
Query: 191 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF 250
CGTPEYLAPE++ Y +AVDWW LGV++YEM G PF+ +++E I+ ++F
Sbjct: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
Query: 251 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 310
P SSD K LL LL D KR G + +I H +F+ +W +Y +K+ PF P+
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 311 FKGPGDTSNFD-DYEEEEIRVSINEK 335
DT FD ++ + I ++ EK
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPPEK 451
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (675), Expect = 8e-71
Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
+++FE +K LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+LQ
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206
Query: 93 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152
PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS
Sbjct: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266
Query: 153 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 208
+++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y
Sbjct: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326
Query: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
+AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+
Sbjct: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386
Query: 269 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 322
D +R G +I H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (675), Expect = 8e-71
Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
+++FE +K LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+LQ
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206
Query: 93 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152
PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS
Sbjct: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266
Query: 153 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 208
+++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y
Sbjct: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326
Query: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
+AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+
Sbjct: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386
Query: 269 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 322
D +R G +I H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 264 bits (675), Expect = 8e-71
Identities = 133/294 (45%), Positives = 186/294 (63%), Gaps = 4/294 (1%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
+++FE +K LG G+FG+V+LVK K TG +YAMKIL K+ +V ++ HTL E R+LQ
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 206
Query: 93 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152
PFL L++SF+ + L VMEY GGE+F HL R FSE ARFY A+IV +YLHS
Sbjct: 207 HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHS 266
Query: 153 -LDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGY 208
+++YRDLK ENL++D+ G+I++TDFG K G T T CGTPEYLAPE++ Y
Sbjct: 267 EKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY 326
Query: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
+AVDWW LGV++YEM G PF+ +++E I+ ++RFP + K LL LL+
Sbjct: 327 GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKK 386
Query: 269 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 322
D +R G +I H++FA W +Y++K+ PF P+ DT FD+
Sbjct: 387 DPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 251 bits (640), Expect = 9e-67
Identities = 125/297 (42%), Positives = 180/297 (60%), Gaps = 7/297 (2%)
Query: 32 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 91
+L F LG G FG+V+L ++K T +A+K L K +V +++ + EKRI + V
Sbjct: 653 NLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 712
Query: 92 N---FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 148
N PFLV L F+ ++ VMEY GG++ H+ FSEP A FYAA +VL +
Sbjct: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQ 771
Query: 149 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILS 205
YLH ++YRDLK +NLL+D +G++++ DFG K G RT T CGTPE+LAPE++
Sbjct: 772 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 831
Query: 206 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 265
Y +AVDWW LGVLIYEM G PF D ++++ IV+ +VR+P S++ ++R L
Sbjct: 832 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 891
Query: 266 LQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD 322
L+ + +R G + D+K H +F DW A+ +KV+ PFIP +G D SNFDD
Sbjct: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 948
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 250 bits (638), Expect = 1e-66
Identities = 126/302 (41%), Positives = 181/302 (59%), Gaps = 6/302 (1%)
Query: 36 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNFP 94
F+ +K +G GSFG+V+L K K G YA+K+L K+ V+ K+ +H + E+ +L + V P
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 95 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 154
FLV L +SF+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 155 LIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKA 211
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 212 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 271
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQ 401
Query: 272 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD-YEEEEIRV 330
R G K +I+NH +F + W + Q+K+ PF P GP D NFD + EE +
Sbjct: 402 NRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPY 460
Query: 331 SI 332
S+
Sbjct: 461 SV 462
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 250 bits (638), Expect = 1e-66
Identities = 126/302 (41%), Positives = 181/302 (59%), Gaps = 6/302 (1%)
Query: 36 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNFP 94
F+ +K +G GSFG+V+L K K G YA+K+L K+ V+ K+ +H + E+ +L + V P
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 95 FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLD 154
FLV L +SF+ LY V+++V GGE+F HL+R F E ARFYAA+I YLHS+
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 155 LIYRDLKPENLLIDQQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKA 211
++YRDLKPEN+L+D G++ +TDFG K + T T CGTPEYLAPE+I + Y+
Sbjct: 282 IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 212 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLT 271
VDWW LG ++YEM G PPF+ ++Y+ I+ + S +L LL+ D
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQ 401
Query: 272 KRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD-YEEEEIRV 330
R G K +I+NH +F + W + Q+K+ PF P GP D NFD + EE +
Sbjct: 402 NRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPY 460
Query: 331 SI 332
S+
Sbjct: 461 SV 462
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 249 bits (637), Expect = 2e-66
Identities = 130/307 (42%), Positives = 192/307 (62%), Gaps = 6/307 (1%)
Query: 27 AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 86
+ N +D FE I+ LG GSFG+VML + KETG+ YA+K+L K +++ +E T+ EKR
Sbjct: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405
Query: 87 ILQ-AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 145
IL A N PFL +L F+ L+ VME+V GG++ H+++ RF E ARFYAA+I+
Sbjct: 406 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 465
Query: 146 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEI 202
+LH +IYRDLK +N+L+D +G+ ++ DFG K G T T CGTP+Y+APEI
Sbjct: 466 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525
Query: 203 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLL 262
+ Y AVDWWA+GVL+YEM G+ PF A+ ++E I++ +V +P+ D +L
Sbjct: 526 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 585
Query: 263 RNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 321
++ + + T R G+L + G + I H +F DW + R++E PF P+ K D SNFD
Sbjct: 586 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFD 645
Query: 322 -DYEEEE 327
D+ +EE
Sbjct: 646 PDFIKEE 652
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 241 bits (616), Expect = 5e-64
Identities = 133/327 (40%), Positives = 194/327 (59%), Gaps = 16/327 (4%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQ-AV 91
LD+F IK LG GSFG+VML + K YA+K+L K +++ ++ T+ EKRIL A
Sbjct: 405 LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALAR 464
Query: 92 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 151
P+L +L F+ L+ VMEYV GG++ ++R +F EP +RFYAA++ +LH
Sbjct: 465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLH 524
Query: 152 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKGY 208
+IYRDLK +N+L+D +G+ ++ DFG K + G T T CGTP+Y+APEI+ Y
Sbjct: 525 QHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEY 584
Query: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
+VDWWALGVL+YEM AG PPF AD ++E I+ V +P S + +L+ +
Sbjct: 585 GPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTK 644
Query: 269 DLTKRFGNL--KNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD-DYEE 325
+ KR G + +NG + IK H +F DW+ + Q+K++ PF P+ K D +NFD D+
Sbjct: 645 NPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTR 704
Query: 326 EE---------IRVSINEKCGKEFSEF 343
EE I IN++ K FS F
Sbjct: 705 EEPVLTLVDEAIVKQINQEEFKGFSYF 731
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 241 bits (616), Expect = 5e-64
Identities = 124/308 (40%), Positives = 185/308 (60%), Gaps = 5/308 (1%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
L F + LG GSFG+VML + K T YA+KIL K V++ +E T+ EKR+L
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 93 FP-FLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 151
P FL +L F+ LY VMEYV GG++ H++++GRF EPHA FYAA+I + +L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 152 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGY 208
S +IYRDLK +N+++D +G+I++ DFG K T T CGTP+Y+APEII + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
K+VDWWA GVL+YEM AG PF + ++++ I+ V +P S + + + L+
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 269 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD-DYEEEE 327
KR G G DIK H +F DW + +++++ P+ PK + DTSNFD ++ +
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 638
Query: 328 IRVSINEK 335
+ ++ +K
Sbjct: 639 VELTPTDK 646
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 239 bits (611), Expect = 2e-63
Identities = 127/302 (42%), Positives = 187/302 (61%), Gaps = 14/302 (4%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHK---ETGNHYAMKILDKQKVV-KLKQIEHTLNEKRIL 88
++ FE +K LGTG++G+V LV+ + G YAMK+L K +V + K EHT E+ +L
Sbjct: 30 VENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 89 QAVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 147
+ V PFLV L ++F+ ++ L+++++YV GGEMF+HL + F E R Y +IVL
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLAL 149
Query: 148 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTLCGTPEYLAPEII 203
E+LH L +IYRDLK EN+L+D +G+I +TDFG +K K RT++ CGT EY+APEII
Sbjct: 150 EHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEII 209
Query: 204 LSK-GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSHFSSDL 258
SK G+ KAVDWW+LG+L++E+ G PF + ++ +I+ FP
Sbjct: 210 RSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVA 269
Query: 259 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTS 318
+DLL+ LL D KR G G +++NH +F DW+A+ RK+ APF P+ + D
Sbjct: 270 QDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVG 329
Query: 319 NF 320
NF
Sbjct: 330 NF 331
Score = 116 bits (290), Expect = 3e-26
Identities = 85/267 (31%), Positives = 138/267 (51%), Gaps = 29/267 (10%)
Query: 30 TAHLDQFE---RIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKR 86
+A + Q+E R LG GSF + +++G +A+KIL ++ ++ L R
Sbjct: 396 SAMMQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL---R 452
Query: 87 ILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 146
+ Q+ P +V L D + Y+V+E + GGE+ H+R+ FSE A +V
Sbjct: 453 LCQS--HPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSA 510
Query: 147 FEYLHS-LDLIYRDLKPENLLI--DQQGY-IQVTDFGFAKRVKGRT-----WTLCGTPEY 197
++H +++RDLKPEN+L D G +++ DFGFA R++ ++ T C T +Y
Sbjct: 511 VSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQY 569
Query: 198 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA-------DQPIQIYEKIVSGKVRF 250
APE++ +GY+++ D W+LGV++Y M +G PF Q +I KI G+
Sbjct: 570 AAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSL 629
Query: 251 PSH----FSSDLKDLLRNLLQVDLTKR 273
S + K+L+R LL VD KR
Sbjct: 630 DGEAWQGVSEEAKELVRGLLTVDPAKR 656
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 239 bits (611), Expect = 2e-63
Identities = 127/302 (42%), Positives = 187/302 (61%), Gaps = 14/302 (4%)
Query: 33 LDQFERIKTLGTGSFGRVMLVKHK---ETGNHYAMKILDKQKVV-KLKQIEHTLNEKRIL 88
++ FE +K LGTG++G+V LV+ + G YAMK+L K +V + K EHT E+ +L
Sbjct: 30 VENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 89 QAVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 147
+ V PFLV L ++F+ ++ L+++++YV GGEMF+HL + F E R Y +IVL
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLAL 149
Query: 148 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----KGRTWTLCGTPEYLAPEII 203
E+LH L +IYRDLK EN+L+D +G+I +TDFG +K K RT++ CGT EY+APEII
Sbjct: 150 EHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEII 209
Query: 204 LSK-GYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSHFSSDL 258
SK G+ KAVDWW+LG+L++E+ G PF + ++ +I+ FP
Sbjct: 210 RSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVA 269
Query: 259 KDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTS 318
+DLL+ LL D KR G G +++NH +F DW+A+ RK+ APF P+ + D
Sbjct: 270 QDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVG 329
Query: 319 NF 320
NF
Sbjct: 330 NF 331
Score = 116 bits (290), Expect = 3e-26
Identities = 85/269 (31%), Positives = 138/269 (51%), Gaps = 29/269 (10%)
Query: 28 QNTAHLDQFE---RIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 84
Q++ Q+E R LG GSF + +++G +A+KIL ++ ++ L
Sbjct: 400 QDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL-- 457
Query: 85 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 144
R+ Q+ P +V L D + Y+V+E + GGE+ H+R+ FSE A +V
Sbjct: 458 -RLCQS--HPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLV 514
Query: 145 LTFEYLHS-LDLIYRDLKPENLLI--DQQGY-IQVTDFGFAKRVKGRT-----WTLCGTP 195
++H +++RDLKPEN+L D G +++ DFGFA R++ ++ T C T
Sbjct: 515 SAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTL 573
Query: 196 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFA-------DQPIQIYEKIVSGKV 248
+Y APE++ +GY+++ D W+LGV++Y M +G PF Q +I KI G+
Sbjct: 574 QYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRF 633
Query: 249 RFPSH----FSSDLKDLLRNLLQVDLTKR 273
S + K+L+R LL VD KR
Sbjct: 634 SLDGEAWQGVSEEAKELVRGLLTVDPAKR 662
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,061,116
Number of Sequences: 37866
Number of extensions: 569796
Number of successful extensions: 3419
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 718
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 1086
Number of HSP's gapped (non-prelim): 897
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.