Search of human proteins with 46592991

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
         (841 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]      1602   0.0  
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]      1082   0.0  
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        142   2e-33
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       134   3e-31
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       134   3e-31
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        134   3e-31
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        134   3e-31
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        134   3e-31
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        134   3e-31
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        134   3e-31
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        134   3e-31
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   126   7e-29
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...   125   2e-28
gi|21735548 centrosomal protein 2 [Homo sapiens]                      124   4e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    122   1e-27
gi|31982906 cingulin-like 1 [Homo sapiens]                            122   1e-27
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]                   120   5e-27
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   120   5e-27
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            120   7e-27
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    118   2e-26
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...   117   6e-26
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   117   6e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   115   1e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   115   2e-25
gi|148746195 trichohyalin [Homo sapiens]                              114   4e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    114   4e-25
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]   114   4e-25
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                 114   5e-25
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]   113   6e-25
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   113   6e-25

>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
          Length = 841

 Score = 1602 bits (4147), Expect = 0.0
 Identities = 841/841 (100%), Positives = 841/841 (100%)

Query: 1   MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
           MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS
Sbjct: 1   MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60

Query: 61  KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
           KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG
Sbjct: 61  KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120

Query: 121 AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
           AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA
Sbjct: 121 AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180

Query: 181 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
           PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE
Sbjct: 181 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240

Query: 241 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300
           SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ
Sbjct: 241 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300

Query: 301 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 360
           GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR
Sbjct: 301 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 360

Query: 361 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 420
           EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ
Sbjct: 361 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 420

Query: 421 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 480
           EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK
Sbjct: 421 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 480

Query: 481 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ 540
           KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ
Sbjct: 481 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ 540

Query: 541 QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600
           QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ
Sbjct: 541 QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600

Query: 601 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660
           RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ
Sbjct: 601 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660

Query: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQ 720
           TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQ
Sbjct: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQ 720

Query: 721 EKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDL 780
           EKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDL
Sbjct: 721 EKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDL 780

Query: 781 VKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGET 840
           VKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGET
Sbjct: 781 VKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGET 840

Query: 841 S 841
           S
Sbjct: 841 S 841


>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
          Length = 625

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 600/704 (85%), Positives = 606/704 (86%), Gaps = 82/704 (11%)

Query: 1   MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
           MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS
Sbjct: 1   MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60

Query: 61  KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
           KSKKAQEVEVLLSENEMLQAKLH                     SQ E    +N  L   
Sbjct: 61  KSKKAQEVEVLLSENEMLQAKLH---------------------SQEEDFRLQNSTL--- 96

Query: 121 AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
                                AE +         +ERYGKEAGKFSAVSEGQGDPPGGPA
Sbjct: 97  --------------------MAEFS---------KERYGKEAGKFSAVSEGQGDPPGGPA 127

Query: 181 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
           PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE
Sbjct: 128 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 187

Query: 241 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300
           SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ
Sbjct: 188 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 247

Query: 301 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 360
           GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR
Sbjct: 248 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 307

Query: 361 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 420
           EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ
Sbjct: 308 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 367

Query: 421 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 480
           EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK
Sbjct: 368 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 427

Query: 481 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ 540
           KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE       
Sbjct: 428 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE------- 480

Query: 541 QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600
                              GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ
Sbjct: 481 -------------------GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 521

Query: 601 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660
           RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ
Sbjct: 522 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 581

Query: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELS 704
           TGDSSSISSFSYREILREKESSAVPAR      + +P  PA L+
Sbjct: 582 TGDSSSISSFSYREILREKESSAVPARVRG---KEEPTAPASLN 622



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 50/232 (21%), Positives = 97/232 (41%), Gaps = 22/232 (9%)

Query: 605 KKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE-ELVLSE---MNSPSRTQ 660
           +K    L  L++++    K   K Q+ L      SKS+   E E++LSE   + +   +Q
Sbjct: 32  RKNGVELTSLRQKVAYLDKEFSKAQKAL------SKSKKAQEVEVLLSENEMLQAKLHSQ 85

Query: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP---RPAELSDEEVAELFQRLAE 717
             D    +S    E  +E+        S  S  Q  PP    P  L+   +AE+  +   
Sbjct: 86  EEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEM 145

Query: 718 TQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVL 777
            ++EK +L E+++ LE S  +    L  + A +   +   +   S     T++  L +  
Sbjct: 146 EKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL--KKKQESFCRLQTEKETLFNDS 203

Query: 778 RDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVG 829
           R+        + E+ ++ +   + QL +   L +++E  +Q +  L  +  G
Sbjct: 204 RN-------KIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQG 248


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  142 bits (357), Expect = 2e-33
 Identities = 221/884 (25%), Positives = 363/884 (41%), Gaps = 117/884 (13%)

Query: 9    EFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-QKALSKSKKAQ- 66
            E  +M  ++ +L   N  LS +LR+    L  L+  +  L +E SKA Q+ L K  + + 
Sbjct: 305  EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGV 126
            E+   L + + L+ K           N  L  + S+L   + QL Q+N   ++G     V
Sbjct: 365  ELSAALQDKKCLEEK-----------NEILQGKLSQLEEHLSQL-QDNPPQEKGEVLGDV 412

Query: 127  AQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAP 186
             Q   L   E   L A NT LQ  V  L+   G++  K  A   G  +       +++  
Sbjct: 413  LQLETLKQ-EAATLAANNTQLQARVEMLETERGQQEAKLLA-ERGHFEEEKQQLSSLITD 470

Query: 187  MPLAEVELKWEMEKEEKRL------LWEQLQGLESSKQAETSRLQE---ELAKLSEKLKK 237
            +  +   L    E+ E+        L  Q+  L S      + +Q+   ELA L ++ K+
Sbjct: 471  LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530

Query: 238  KQESFCRLQTEKETLFNDSRNKIEEL--------QQRKEADHKAQLARTQKLQQELEAAN 289
            KQ    +   ++E      R+++E+L        QQ KE   K +  R    QQ   AA 
Sbjct: 531  KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590

Query: 290  QSLAELRDQ----RQGERL--EHAAALRALQDQVSIQSA---DAQEQVEGLLAENNALRT 340
            +  A LR++    +Q E L  E AA L  LQ Q+ + +     AQ  V     E   L  
Sbjct: 591  EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650

Query: 341  SLAALEQIQTAKTQELNMLREQTTGLAAEL--QQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             +  L+       QE +  + Q   L  +L  +QQ+A  ++ + Q+ D   QLQE L+A 
Sbjct: 651  KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD---QLQEQLQA- 706

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
              L E L+     K  L +E + A  + E+++  + EL  ET     QHK E    R   
Sbjct: 707  --LKESLK---VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE----RKEL 757

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELET-LQQTVEELQAQVHS 517
            E+E  G R   E  L++L E  + + E LR ++ E  A     E+  +Q V+E+ A    
Sbjct: 758  EEERAG-RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA---- 812

Query: 518  MDGAKGWFERRLKEAEESLQ--QQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE-- 573
                  W ER     +E  Q     QEQ   LK+  E+   EL+  +E++  +    E  
Sbjct: 813  ------WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866

Query: 574  ---QAQEERDCHLKTISSLKQEVKDTVDGQRI------LEKKGSAALKDLKRQLHLERKR 624
               Q  E  + H     +L+Q  +  V  Q++      L++K +A  K++ R   L RK 
Sbjct: 867  ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK- 925

Query: 625  ADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAV 684
            A + QE     L    +R+G  +    E     R      +++ +          E   +
Sbjct: 926  AGEQQETASRELVKEPARAGDRQPEWLE-EQQGRQFCSTQAALQAMEREAEQMGNELERL 984

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAE-DL 743
             A  + S  Q Q  R  +  + EVA L Q     Q +          L +  A+ AE ++
Sbjct: 985  RAALMESQGQQQEERGQQ--EREVARLTQERGRAQAD----------LALEKAARAELEM 1032

Query: 744  CRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNM--LEE 801
              ++A+ E  V  + +  ++A   T++ G    L  L       ++E+ +  Q +  L+E
Sbjct: 1033 RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE 1092

Query: 802  QLTKNMHLHKD------------------MEVLSQEIVRLSKEC 827
            QL K    H                    +E L  E+ +L ++C
Sbjct: 1093 QLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136



 Score =  101 bits (251), Expect = 3e-21
 Identities = 177/776 (22%), Positives = 317/776 (40%), Gaps = 112/776 (14%)

Query: 1    MAQALSEE--EFQRMQAQLLELRTNNYQLSDELRK-NGVE------LTSLRQKVAYLDKE 51
            +  AL+E+  EF  +Q  L    T       EL K  G+E      L  LRQ V  L ++
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093

Query: 52   FSKAQKALSKSKKAQ------------EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAE 99
             +K +K  +    AQ            ++E L +E   L+ +   Q+E       +L AE
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153

Query: 100  FSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYG 159
             +    +   LE    QL+E A   G +Q+       L   Q E  A +  V    + + 
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSA------LASAQRELAAFRTKV----QDHS 1203

Query: 160  KEAGKFSA-VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQ 218
            K   ++ A V+ G+ +                +  L   +E+E   L  + L+     K+
Sbjct: 1204 KAEDEWKAQVARGRQEAE-------------RKNSLISSLEEEVSILNRQVLE-----KE 1245

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKI------EELQQRKEADHK 272
             E+  L+  +   SEK +K +E    LQ E  T  N +R         EE+Q  +E   K
Sbjct: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAE--TASNSARAAERSSALREEVQSLREEAEK 1303

Query: 273  AQLARTQKLQQELEAANQSLAELRDQR---QGERLEHAAALRALQDQVSIQSADAQEQVE 329
             ++A ++ L+QEL +  +   EL  +    Q +  +   AL  LQ    ++    Q  V 
Sbjct: 1304 QRVA-SENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ----LEHTSTQALVS 1358

Query: 330  GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNS 389
             LL   +  +   A     +    +EL   ++   GL AEL + Q E  +L+  +  +  
Sbjct: 1359 ELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAE 1418

Query: 390  QLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKE 449
            Q + + +  +      +++   K+      +E R   E+       L +E  Q + ++ +
Sbjct: 1419 QERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQ 1478

Query: 450  ELGAVRLRHEKEVLGVRARYERELREL------HEDKKRQEEELRGQIREEK----ARTR 499
            EL AVR   E  +  V+   +   REL      +E  K +  E R + +EE+    A+  
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1538

Query: 500  ELETLQ----QTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHA 555
            +LE  Q    + VEEL  ++   D A    +++LK  +    + QQE +    Q  E   
Sbjct: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ- 1597

Query: 556  AELKGKEEELQDVRDQLEQAQEERDC----------HLKTISSLKQEVKD-TVDGQRI-- 602
            A+L  KE+  +  + Q+E+A+   D            L+++  L++E K+   + +R+  
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGH 1657

Query: 603  -LEKKG-------------SAALKDLKRQL-HLERKRADKLQERLQDILTNSKSRSGLEE 647
             L++ G             +A ++ L+ Q+ H +++  D  + ++      S+      +
Sbjct: 1658 ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717

Query: 648  LVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAEL 703
            L LS  +     + G   SI+S   R    + + ++VP    S   Q  PP+   L
Sbjct: 1718 LDLSIDSLDLSCEEGTPLSITSKLPR---TQPDGTSVPGEPASPISQRLPPKVESL 1770



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 157/743 (21%), Positives = 292/743 (39%), Gaps = 118/743 (15%)

Query: 192 VELKWEMEKEEKRLLWEQLQG-LESSKQAET--SRLQEELAKLSEKLKKKQESFCRLQTE 248
           V LK+ ++ E+   L E L+  L+ +    T  S   EEL+  S + K++      L+ +
Sbjct: 129 VILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRF---LELQ 185

Query: 249 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
           K    +   N +        A     + +T + Q  +    + LA+ R  R    LE  A
Sbjct: 186 KVASSSSGNNFLSG----SPASPMGDILQTPQFQ--MRRLKKQLADERSNRDELELE-LA 238

Query: 309 ALRALQDQVSIQSADAQEQVEGLLAENNALRTS------LAALEQIQTAKTQELNMLREQ 362
             R L  +   Q A  Q++++ L   N     S      L  L     + T  L+   +Q
Sbjct: 239 ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ 298

Query: 363 TTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEA 422
              L  E  Q   +   L  +  DL+ +L+E      +L + L E+ +E  + TQE  E 
Sbjct: 299 CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358

Query: 423 RKSAEKR--KAMLDELAME--------TLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 472
           +   EK    A+ D+  +E         L +  +H  +L     + + EVLG   + E  
Sbjct: 359 QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418

Query: 473 LRE-----------------LHEDKKRQEEEL---RGQIREEKARTRELET--------L 504
            +E                 L  ++ +QE +L   RG   EEK +   L T        L
Sbjct: 419 KQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL 478

Query: 505 QQTVEELQ-------------------------AQVHSMDGAKGWFERRLKEAEESLQQQ 539
            Q  EEL+                         A +   D      +++ KE +  L Q 
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538

Query: 540 QQEQEEALKQCR---EQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQ----E 592
            Q+QE+A +  R   EQ ++ LK KE++L++V ++ E  +++    L T +  ++    E
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE 598

Query: 593 VKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQ-----------------ERLQDI 635
               +     LEK+ +A L+ L++QL +  +  D  Q                 E LQ  
Sbjct: 599 RDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC 658

Query: 636 LTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAV--PARSLSSSP 693
           +  ++      +  ++E+    R++   ++     +  +   +++  A+    +    S 
Sbjct: 659 VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718

Query: 694 QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAI---- 749
           + +  R A+  +E+   + +  AET+      + + K LE   A       R   +    
Sbjct: 719 EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAH 778

Query: 750 -IETYVMDSRIDVSVAAGHTDRSGLGSVLRDLV--KPGDENLREMNKKLQNMLEEQLTKN 806
             ET V+   +  ++AA HT  S    +++++   +   E+ ++   +   M +EQL   
Sbjct: 779 QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQL--- 835

Query: 807 MHLHKDMEVLSQEIVRLSKECVG 829
           M L ++ E   QE+    ++  G
Sbjct: 836 MTLKEECEKARQELQEAKEKVAG 858


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1664 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1711

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1770

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1951 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2057

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2058 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2158

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2215

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2216 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2271

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2272 KMKQVAEEAAR--------LSVAAQEAARL 2293



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 2009 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2122

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2180

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2181 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2344

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2345 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2450

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2451 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2611

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2612 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2655

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2699



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1882

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1883 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2291

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2292 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2408 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2576

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2175

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2176 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2230 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2286

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2340

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2401 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2447

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2505

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2506 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2554

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2555 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2600

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2601 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2654

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2655 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2707



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1643

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1758

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1819 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1873

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1926

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1927 ILALKASFEKAA 1938



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1081

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1182

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1183 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1234

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1282

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1510

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1568

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1687

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1515 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1570

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1686

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1918

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1919 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1949



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2440

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2441 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2544

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2654

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2655 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2700

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2701 LLLKATNEKLSVYAALQRQL 2720



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 551

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 552 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 668

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 669 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 717

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 718 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 776

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 777 YKGHLSGLAKRAK 789



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 624

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 625  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 683

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 684  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 739

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 740  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 859

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 860  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 917

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 918  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 977

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 978  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1034

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1206

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1207 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1668 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1715

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1774

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1955 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2008

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 2009 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2061

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2062 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2162

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2219

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2220 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2275

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2276 KMKQVAEEAAR--------LSVAAQEAARL 2297



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 2013 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2068

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2126

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2184

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2185 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2348

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2349 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2454

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2455 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2502

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2562

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2615

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2616 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2659

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2660 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2703



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1830

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1886

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1887 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1997

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2177

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2295

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2296 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2412 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2580

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLEEQ 2608



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2179

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2180 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2233

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2234 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2290

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2344

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2405 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2451

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2452 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2509

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2510 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2558

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2559 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2604

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2605 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2658

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2659 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2711



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1425

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1480

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1647

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1762

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1823 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1877

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1878 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1930

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1931 ILALKASFEKAA 1942



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1085

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1146 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1186

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1187 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1238

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1286

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1465

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1514

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1572

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1691

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1519 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1574

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1690

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1748

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1809 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1922

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1923 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1953



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2444

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2445 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2548

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2609 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2658

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2659 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2704

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2705 LLLKATNEKLSVYAALQRQL 2724



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 436 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 495

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 496 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 555

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 556 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 615

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 616 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 672

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 673 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 721

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 722 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 780

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 781 YKGHLSGLAKRAK 793



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 573  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 628

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 629  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 687

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 688  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 743

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 744  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 804  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 863

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 864  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 921

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 922  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 981

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 982  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1038

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1210

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1211 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1664 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1711

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1770

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1951 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2057

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2058 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2158

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2215

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2216 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2271

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2272 KMKQVAEEAAR--------LSVAAQEAARL 2293



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 2009 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2122

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2180

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2181 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2344

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2345 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2450

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2451 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2611

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2612 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2655

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2699



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1826

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1882

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1883 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2173

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2291

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2292 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2408 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2576

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2175

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2176 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2229

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2230 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2286

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2340

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2401 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2447

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2505

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2506 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2554

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2555 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2600

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2601 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2654

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2655 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2707



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1643

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1758

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1819 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1873

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1926

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1927 ILALKASFEKAA 1938



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1081

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1182

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1183 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1234

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1282

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1510

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1568

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1687

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1515 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1570

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1686

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1744

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1918

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1919 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1949



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2440

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2441 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2544

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2654

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2655 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2700

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2701 LLLKATNEKLSVYAALQRQL 2720



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 551

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 552 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 668

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 669 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 717

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 718 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 776

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 777 YKGHLSGLAKRAK 789



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 569  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 624

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 625  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 683

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 684  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 739

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 740  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 859

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 860  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 917

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 918  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 977

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 978  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1034

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1206

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1207 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1632 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1679

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1738

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1919 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1972

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2025

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2026 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2126

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2183

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2184 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2239

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2240 KMKQVAEEAAR--------LSVAAQEAARL 2261



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 1977 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2033 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2090

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2148

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2149 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2312

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2313 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2418

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2419 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2466

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2526

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2579

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2580 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2623

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2624 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2667



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1794

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1850

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1851 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1961

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2141

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2259

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2260 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2375

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2376 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2544

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQLLEEQ 2572



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2143

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2144 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2197

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2198 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2254

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2308

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2369 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2415

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2416 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2473

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2474 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2522

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2523 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2568

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2569 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2622

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2623 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2675



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1444

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1611

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1726

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1787 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1841

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1842 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1894

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1895 ILALKASFEKAA 1906



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 993  EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1049

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1110 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1150

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1151 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1202

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1250

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1429

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1478

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1536

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1655

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1483 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1538

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1654

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1712

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1833 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1886

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1887 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1917



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2408

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2409 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2512

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2573 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2622

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2623 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2668

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2669 LLLKATNEKLSVYAALQRQL 2688



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 400 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 459

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 460 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 519

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 520 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 579

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 580 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 636

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 637 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 685

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 686 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 744

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 745 YKGHLSGLAKRAK 757



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 537  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 592

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 593  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 651

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 652  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 707

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 708  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 768  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 827

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 828  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 885

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 886  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 945

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 946  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1002

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1174

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1175 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1801 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1848

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1907

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 2088 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2141

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 2142 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2194

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2195 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2295

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2352

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2353 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2408

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2409 KMKQVAEEAAR--------LSVAAQEAARL 2430



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 2146 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2201

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2202 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2259

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2317

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2318 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2481

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2482 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2587

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2588 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2635

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2695

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2748

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2749 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2792

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2793 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2836



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1963

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 2019

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 2020 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2310

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2428

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2429 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2545 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2713

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQLLEEQ 2741



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2312

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2313 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2366

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2367 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2423

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2477

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2538 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2584

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2642

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2643 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2691

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2692 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2737

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2738 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2791

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2792 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2844



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1558

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1613

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1780

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1895

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1956 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 2010

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 2011 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 2063

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 2064 ILALKASFEKAA 2075



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1218

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1279 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1319

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1320 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1371

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1419

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1598

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1647

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1705

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1824

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1652 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1707

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1823

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1881

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1942 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 2055

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 2056 QRRQVEEEILALK---ASFEKAAAGKAELELELG 2086



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2577

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2578 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2632

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2681

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2742 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2791

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2792 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2837

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2838 LLLKATNEKLSVYAALQRQL 2857



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 569 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 628

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 629 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 688

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 689 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 748

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 749 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 805

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 806 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 854

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 855 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 913

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 914 YKGHLSGLAKRAK 926



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 706  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 761

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 762  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 820

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 821  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 876

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 877  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 937  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 996

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 997  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 1054

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 1055 KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 1114

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 1115 EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1171

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1343

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1344 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1642 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1689

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1748

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1929 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1982

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2035

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2036 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2136

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2193

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2194 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2249

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2250 KMKQVAEEAAR--------LSVAAQEAARL 2271



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 1987 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2043 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2100

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2158

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2159 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2322

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2323 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2428

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2429 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2476

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2589

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2590 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2633

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2634 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2677



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1804

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1860

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1861 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1971

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2031

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2151

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2269

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2270 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2385

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2386 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2440

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2554

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQLLEEQ 2582



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2153

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2154 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2207

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2208 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2264

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2318

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2379 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2425

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2483

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2484 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2532

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2533 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2578

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2579 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2632

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2633 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2685



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1399

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1454

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1621

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1736

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1797 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1851

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1852 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1904

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1905 ILALKASFEKAA 1916



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1059

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1120 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1160

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1161 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1212

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1260

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1439

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1488

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1546

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1665

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1493 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1548

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1664

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1722

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1783 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1843 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1896

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1897 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1927



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2418

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2419 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2473

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2522

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2583 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2632

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2633 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2678

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2679 LLLKATNEKLSVYAALQRQL 2698



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 410 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 529

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 530 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 589

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 590 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 646

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 647 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 695

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 696 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 754

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 755 YKGHLSGLAKRAK 767



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 547  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 602

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 603  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 661

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 662  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 717

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 718  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 778  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 837

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 838  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 895

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 896  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 955

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 956  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1012

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1184

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1185 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1650 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1697

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1698 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1756

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1937 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1990

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 1991 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2043

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2044 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2144

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2201

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2202 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2257

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2258 KMKQVAEEAAR--------LSVAAQEAARL 2279



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 1995 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2050

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2051 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2108

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2166

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2167 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2330

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2331 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2436

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2437 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2484

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2544

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2597

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2598 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2641

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2642 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2685



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1812

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1868

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1869 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1919

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1920 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 1979

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2039

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2159

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2277

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2278 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2393

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2394 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2448

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2562

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQLLEEQ 2590



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2161

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2162 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2215

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2216 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2272

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2326

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2387 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2433

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2434 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2491

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2492 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2540

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2541 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2586

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2587 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2640

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2641 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2693



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1407

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1462

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1629

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1744

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1805 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1859

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1860 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1912

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1913 ILALKASFEKAA 1924



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1067

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1128 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1168

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1169 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1220

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1268

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1447

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1496

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1554

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1673

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1501 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1556

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1672

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1730

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1791 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1850

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1851 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1904

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1905 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1935



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2426

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2427 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2481

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2530

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2591 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2640

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2641 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2686

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2687 LLLKATNEKLSVYAALQRQL 2706



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 418 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 477

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 478 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 537

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 538 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 597

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 598 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 654

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 655 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 703

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 704 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 762

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 763 YKGHLSGLAKRAK 775



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 555  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 610

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 611  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 669

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 670  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 725

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 726  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 786  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 845

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 846  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 903

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 904  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 963

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 964  EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1020

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1192

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1193 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  134 bits (338), Expect = 3e-31
 Identities = 200/870 (22%), Positives = 375/870 (43%), Gaps = 113/870 (12%)

Query: 7    EEEFQRMQAQ--LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK- 63
            E E Q+ QAQ     LR      S   R+  VEL S  +  A   +E  +A +AL + + 
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570

Query: 64   KAQEVEVLLSENEM-----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ--- 115
            +A+E E  L + E+     +Q  L + +     +  +  A F++  +Q+E+  QE     
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630

Query: 116  -QLKEGAAG-----AGVAQAGPLVDGEL------------LRLQAENTALQKNVAALQER 157
             QL+E A       A   +A    + EL            LRLQAE  A QK++A  +  
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
              KE  +  A   G+ +         +    LAE EL      E++R L E       + 
Sbjct: 1691 KQKEEAEREARRRGKAEEQA------VRQRELAEQEL------EKQRQLAEGTAQQRLAA 1738

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 277
            + E  RL+ E  +  ++ +  +E   RLQ E        R ++E    +  A+ +  LA 
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAKVRAEMEVLLAS 1797

Query: 278  TQKLQQELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
              + ++E  + ++   +  +   G   E  E AA LRAL ++   Q   A+E      AE
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857

Query: 335  -NNALRTSLAALEQIQTAKTQELNMLREQTTG------LAAELQQQQAEYEDLMGQ-KDD 386
                L   LAA+ +    KT+    L+E+         LA +   Q+   E+   Q K D
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917

Query: 387  LNSQLQESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +  +L +  +A+   LE+    +++  +++ Q+ +E+   + S EK  A   EL +E  +
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ-EEELRGQIREEKARTREL 501
             +S  ++ L        KE   + A  +R+L    E ++R+ EE ++  +  E+   R+ 
Sbjct: 1978 IRSNAEDTL------RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2031

Query: 502  ETLQQTVEELQAQVHSM----DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
            +   + VE L+A+V       + A+    R+L+ A+E+ Q++ Q +E+A       HA  
Sbjct: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------HAFA 2084

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
            ++ KE+ELQ     L+Q Q   D       + ++  ++  + +   E++ + + + ++  
Sbjct: 2085 VQQKEQELQQT---LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141

Query: 618  LHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 677
              L++   ++ Q R Q      K R        +E  +  R Q   ++          LR
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKE------AEQEAARRAQAEQAA----------LR 2185

Query: 678  EKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            +K+++           +    + A++ ++E+  L  +L ET  +K +L+E+++ L+    
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQRLKAE-- 2242

Query: 738  SMAEDLCRKSAIIETYVMDSRI---DVSVAAGHTDRSGLGSVLRDLVKPGDEN-LREMNK 793
              A +  R+ + +E  +   R+   ++S      +      +LRD  K   +  L+E  +
Sbjct: 2243 --ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--KDNTQRFLQEEAE 2298

Query: 794  KLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
            K++ + EE           + V +QE  RL
Sbjct: 2299 KMKQVAEEAAR--------LSVAAQEAARL 2320



 Score =  122 bits (307), Expect = 1e-27
 Identities = 168/764 (21%), Positives = 332/764 (43%), Gaps = 104/764 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            EE +R++A++ E R    +L +   +       L Q+ A    +  +   A +  +K QE
Sbjct: 2036 EEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091

Query: 68   VEVLLSENEMLQAKLHSQEEDFR-----LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            ++  L + + +  +L  + E  R      + + + AE  +  +Q  +  +E ++LK+ A 
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRRQVEEAERLKQSAE 2149

Query: 123  GAGVAQAGPLVDGELLRLQAENTAL---QKNVAALQERYGKEAG-----KFSAVSEGQGD 174
                A+A      E LR +AE  A    Q   AAL+++   +A      KF+  +  Q  
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-- 2207

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQA-ETSRLQEELAKL 231
                          L  + L+ E    +K LL E+LQ L  E+++ A + S+++EEL  +
Sbjct: 2208 -------KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260

Query: 232  SEKLKKKQESFCRLQTEKETLF-----NDSRNKIEELQQRKEADHKA--------QLART 278
              ++++  +   R++ E   L      N  R   EE ++ K+   +A        + AR 
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
            ++L +E  A  ++LAE   + + + ++ A  L+A  + +  Q   AQEQ           
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--------- 2371

Query: 339  RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
                    ++Q  K Q    L E+T G    L+ ++    ++  + + L  ++ E  RA 
Sbjct: 2372 --------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423

Query: 399  SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            +R  E  Q   ++ E++ ++L     + +++  ++  L ++  +++S H  E    RLR 
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ--RQQSDHDAE----RLRE 2477

Query: 459  EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM 518
                    A  ERE     ++K +QE +L  Q++ E+ +T + E L Q  + LQ    S 
Sbjct: 2478 ------AIAELERE-----KEKLQQEAKLL-QLKSEEMQTVQQEQLLQETQALQQSFLSE 2525

Query: 519  DGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEE 578
              +    ER +++ +  L+Q  Q++    +Q RE+   + +  E+E Q +   +E+A+  
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2585

Query: 579  RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN 638
            +    + +   ++E++     +R  E+  +   + L+ QL L       L+E+ +  L +
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL-------LEEQHRAALAH 2638

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
            S      EE+  S++ +      G          R+ L    + A P  S     +    
Sbjct: 2639 S------EEVTASQVAATKTLPNG----------RDALDGPAAEAEPEHSFDGLRRKVSA 2682

Query: 699  RPAELSDEEVAELFQRLAE--TQQEKWMLEEKVKHLEVSSASMA 740
            +  + +    AE  QRLA+  T  ++    E V+H     +S+A
Sbjct: 2683 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA 2726



 Score =  118 bits (296), Expect = 2e-26
 Identities = 209/928 (22%), Positives = 381/928 (41%), Gaps = 148/928 (15%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
            +E+E  R++A+  +       L +EL +   E  +  QK   L+ E +K  A+  +  + 
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
            KA+  E   S +E  + +L ++   FR     L  E ++L +  E+ +++ Q  +E AA 
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1853

Query: 124  AGVAQAGPLVD-----GELLRLQAENTALQKNVAALQERYGK----EAGKFSAVSEGQGD 174
                    L +     GE  RL+ E     K   A  ER  +    EA +   + E    
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE---- 1909

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                      A    A++E +    ++      E+ +GL      +  +++EE+  L   
Sbjct: 1910 ---------QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1960

Query: 235  LKKKQESFCRLQTE--------KETLFNDSRNKIEELQQRKEADHKAQLAR------TQK 280
             +K       L+ E        ++TL +  + ++E  +QR+ A  + +  R       + 
Sbjct: 1961 FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS 2020

Query: 281  LQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSAD-AQEQVE-GLLAENNA 337
            L  E EAA Q  A L + +R   ++E A  LR   +Q S +    AQE  +  L AE  A
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2080

Query: 338  LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 397
               ++   EQ      Q+   + +Q  G A   ++   E E+   Q +   +Q +  +  
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEK---RKAMLDELAM---------------- 438
              RL +  +E  Q + Q     ++ RK AE+   R+A  ++ A+                
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF 2200

Query: 439  --ETLQEKSQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL--- 473
              +TL++K+Q ++EL  +RL+     H+K +L                 R++ E EL   
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260

Query: 474  ----RELHEDKKRQEEELRGQIREEKARTR-----ELETLQQTVEE-LQAQVHSMDGAKG 523
                 EL + K R E E R  I  +K  T+     E E ++Q  EE  +  V + + A  
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-- 2318

Query: 524  WFERRLKE-AEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQD----VRDQLEQAQ 576
                RL++ AEE L QQ+   E+ LK+  +  Q A  LK + E LQ      ++Q  + Q
Sbjct: 2319 ----RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2374

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK--------RQLHLE------R 622
            E+++   + ++   Q  + T++ +R  + + SA  + LK         Q   E      R
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2434

Query: 623  KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 682
            K+A+++ E+L     +    +  E++ L +     R Q+   +     +  E+ REKE  
Sbjct: 2435 KQAEEIGEKL-----HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2489

Query: 683  AVPARSLS-SSPQAQPPRPAELSDE----------EVAELFQRLAETQQEKWMLEEKVKH 731
               A+ L   S + Q  +  +L  E          E   L QR    +QEK  LE+  + 
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
                +  + E+  R+   +E         +  A      +  G      V+   E L+++
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG------VRRKQEELQQL 2603

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             ++ +   E    +N  L + +++L ++
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQLLEEQ 2631



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/656 (23%), Positives = 288/656 (43%), Gaps = 67/656 (10%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            + Q+  E+   R QAQ    +       +  R+   E  +LRQK A  D E  K +K   
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2202

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            ++ + Q+ +V   E E+   +L  +E D   Q + L  E  +L ++  +  ++  Q++E 
Sbjct: 2203 QTLR-QKAQV---EQELTTLRLQLEETDH--QKNLLDEELQRLKAEATEAARQRSQVEEE 2256

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTAL-QKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                 V      +     R++AEN AL  ++    Q    +EA K   V+E +       
Sbjct: 2257 LFSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE-EAARLSVA 2313

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
            A        LAE +L  +    EK +L E++Q ++     E +RL+ E   L ++ +  Q
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQKELAQ 2367

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAELRDQ 298
            E   RLQ +KE +      + +  Q+  EA+ + QL  + + ++ +L  A  S A+ R +
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427

Query: 299  RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 358
               +R    A    + +++       QE+V           T +  LE  +     +   
Sbjct: 2428 EDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDHDAER 2474

Query: 359  LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE 418
            LRE    L  E ++ Q E + L  + +++ +  QE L   ++ L+  Q    EK+ L Q 
Sbjct: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ--QSFLSEKDSLLQR 2532

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
                 +  E+ KA L++L  + + +  Q +EE    + + E+E        +R +  + E
Sbjct: 2533 ----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE-------RQRLVASMEE 2581

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
             ++RQ E   G +R ++   ++LE  ++  EEL A+ +          +RL+   E LQ 
Sbjct: 2582 ARRRQHEAEEG-VRRKQEELQQLEQQRRQQEELLAEEN----------QRLR---EQLQL 2627

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
             +++   AL    E  A+++    + L + RD L+    E +    +   L+++    V 
Sbjct: 2628 LEEQHRAALAHSEEVTASQV-AATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VS 2681

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             QR L++ G  + ++L+R L       D+L  R +D+    + RS +  L+L   N
Sbjct: 2682 AQR-LQEAGILSAEELQR-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2734



 Score =  100 bits (250), Expect = 4e-21
 Identities = 131/612 (21%), Positives = 248/612 (40%), Gaps = 70/612 (11%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 248
            LAEVE   E +++      +     E   +    R+QEE+ +  E     Q+    +Q E
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1448

Query: 249  KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 308
             + L   S  +I+   ++ EA  +++L    ++++E+      L     QR G   E   
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1503

Query: 309  ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 346
            ALRA  ++   Q   AQE+ E L                       AE  A R    AL+
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563

Query: 347  QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 395
             ++  + Q           E+   R+    L    +  +AE +       +  +QL+ SL
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623

Query: 396  RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455
            +     + QL+E  + + Q   E + AR+ AE+         +E  Q K+       A+R
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1670

Query: 456  LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEELQA 513
            LR + E +  +    +   E  +++  +E   RG+  E+  R REL  + L++  +  + 
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
                   A+    R   E E+  QQ+Q  +EE  +  RE  AA  K +E E      +L 
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA-----ELA 1785

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
            + + E +  L + +  ++E + T +  +   +  +   ++L  +    R  A++ + + Q
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
                ++  +    E VL+E         G+++ + +      L+EKE+     R L+   
Sbjct: 1846 LAEEDAARQRAEAERVLAE----KLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDE 1900

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
              Q  R  E + +  A++ +RLA+ ++      E+ K        + ED  R+   +E  
Sbjct: 1901 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK-------GLVEDTLRQRRQVEEE 1953

Query: 754  VMDSRIDVSVAA 765
            ++  +     AA
Sbjct: 1954 ILALKASFEKAA 1965



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 178/755 (23%), Positives = 305/755 (40%), Gaps = 105/755 (13%)

Query: 30   ELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLH---SQE 86
            E +K   E+  L + VA L  E   A+K L+  + +     L SE E+   KL    S  
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1108

Query: 87   EDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTA 146
              +  +  T+           E L    +QLKE  A              L +L+A+  A
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168

Query: 147  LQKNVAALQE--RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR 204
             Q    AL++  R  +E G+      G+ D                EVE +W   +E   
Sbjct: 1169 QQPTFDALRDELRGAQEVGERLQQRHGERD---------------VEVE-RW---RERVA 1209

Query: 205  LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
             L E+ Q +     A+T   Q EL +L  +L+  +ES   L         D+R + E++Q
Sbjct: 1210 QLLERWQAV----LAQTDVRQRELEQLGRQLRYYRESADPLGA----WLQDARRRQEQIQ 1261

Query: 265  QRKEADHKA---QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA-----LRALQD- 315
                AD +A   QL + Q L +E+E            R GE++E         + A++D 
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIE------------RHGEKVEECQRFAKQYINAIKDY 1309

Query: 316  QVSIQSADAQ-EQVEGLLAENNALRTSLAALEQIQTAKTQ--ELNMLREQTTGLAAELQQ 372
            ++ + +  AQ E V     +      S + +++    +T   EL  L  Q     +E  +
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369

Query: 373  QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI-GQEKEQLTQELQEARKSAEKRKA 431
            +  E E L  Q+     +    + A      QL E   Q K Q  +E +E ++  ++   
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 432  MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY----ERELRELHEDKKRQEEEL 487
              +E A++  Q+K   +EEL  +R   E E+   +AR     ER    + E+ +    +L
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEI-QAKARQAEAAERSRLRIEEEIRVVRLQL 1488

Query: 488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL 547
                R+      EL+ L+   EE +AQ           +R+ +E  E L++Q Q++ +  
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQ-----------KRQAQEEAERLRRQVQDESQRK 1537

Query: 548  KQCREQHAAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTV 597
            +Q   + A+ +K + E           L+++R Q E+A  ER      +   +Q      
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALE 1595

Query: 598  DGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE----RLQDILTNSKSRSGLE 646
              QR  E     K+ S A K   L+R L  E     +L+E    R Q      ++R   E
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655

Query: 647  -ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
             EL   ++ +      R Q  + +   S +  E  ++KE +   AR    + + Q  R  
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQR 1714

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
            EL+++E+ +  Q    T Q++   E+++  L   +
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 146/634 (23%), Positives = 263/634 (41%), Gaps = 36/634 (5%)

Query: 219  AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            +ET R  EE  +L+E+ + ++    RL  E E      R   E   Q K    +      
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421

Query: 279  QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 335
            Q++Q+E+    ++  + + Q++   E L+        + Q   + A+A E+    + E  
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481

Query: 336  NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 394
              +R  L A E+ +     EL  LR +     A+ +Q Q E E L  Q +D+   + Q  
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
            +   SR+  +  E  +EK++  Q L+E R  AE+ +  L +  +E  +   Q +  L   
Sbjct: 1542 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERAR---QVQVALETA 1597

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELR-GQIREE-KARTRELETLQQTVEELQ 512
            +   E E+   RA +  +  +L  ++  QEE +   Q+REE + R ++    ++  EE +
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCRE-QHAAELKGKEEELQDVRDQ 571
             ++           R   +AEE  QQ+   Q EA KQ  E +  A  +GK EE Q VR Q
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE-QAVR-Q 1713

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL------HLERKRA 625
             E A++E +   +      Q+       Q ++  +      + +RQL       L+R+ A
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQ--RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1771

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ-TGDSSSISSFSYREILREKESSAV 684
               Q+R +     +K R+ +E L+ S+  +   ++ T + S     +     RE    A 
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              R+L+   + Q     E +  + AE  + LAE               E++      +  
Sbjct: 1832 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1891

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R   + E      R     AA H  ++ +   L  L K  D  L    ++ + ++E+ L 
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSEL----ERQKGLVEDTLR 1945

Query: 805  KNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPG 838
            +   + +++  L        K   G  + +LE G
Sbjct: 1946 QRRQVEEEILALK---ASFEKAAAGKAELELELG 1976



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 107/500 (21%), Positives = 198/500 (39%), Gaps = 71/500 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   +EE ++M+    E    +    +  R   +    L Q+ A  +K   +  +A+ ++
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349

Query: 63   KKAQ-EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME-------QLEQEN 114
             + + E E+L  + E+ Q +    +ED       L  E       +E       ++  E 
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTA--LQKNVAALQERYGKEAGKFSAVSEGQ 172
            ++LK   A    AQA    D +  R QAE     L +   A QE+      +   +   Q
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQ 2467

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQEEL 228
             D         +A     E+E + E  ++E +LL  + + +++ +Q     ET  LQ+  
Sbjct: 2468 SDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 288
                + L +++    + + + E LF D   K ++L++ +           Q+ QQ++E  
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQMEQE 2571

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ- 347
             Q L    ++ +  + E    +R  Q+++       ++Q E L  EN  LR  L  LE+ 
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631

Query: 348  -------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
                          Q A T+ L   R+   G AAE + + +         D L  ++   
Sbjct: 2632 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS-- 2681

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEELGA 453
                    ++LQE G    +  Q L +   +       +DELA  E ++   Q +  +  
Sbjct: 2682 -------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSIAG 2727

Query: 454  VRLRHEKEVLGVRARYEREL 473
            + L+   E L V A  +R+L
Sbjct: 2728 LLLKATNEKLSVYAALQRQL 2747



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)

Query: 186 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
           P    EVE   +      RLL+  +Q L+  +  +  ++   + +L E+L   +  +   
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 518

Query: 243 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 278
                                 R + E  TL    D    +EE Q R + A+    L   
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 578

Query: 279 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 338
           +         +QS+ E R + +  R +      A +            Q   LL  + A 
Sbjct: 579 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 638

Query: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 398
             SL +L     A T+EL  L E+      E+    ++    M  K +  S L   L   
Sbjct: 639 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 695

Query: 399 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 458
            + +++LQ  G   ++L +E   AR + E  +A         LQ +     +L      H
Sbjct: 696 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 744

Query: 459 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 517
            KE      ++  ++RE     ++ +E LR +   +  A    LE L Q  ++ + Q++ 
Sbjct: 745 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 803

Query: 518 MDGAKGWFERRLK 530
             G      +R K
Sbjct: 804 YKGHLSGLAKRAK 816



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 151/714 (21%), Positives = 279/714 (39%), Gaps = 140/714 (19%)

Query: 218  QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276
            +A+  R + +  +LS   +   ++   RL  +   L N S+ ++  L    E+ H    A
Sbjct: 596  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 651

Query: 277  RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 332
             T++L    ++E E      ++       ++  ++A +R L+ +   +  + Q   + LL
Sbjct: 652  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 710

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 389
             E++  R ++   E  Q A   + + + +    + A L++  A ++   D+   +  L  
Sbjct: 711  REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 766

Query: 390  QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML------- 433
            +LQE+LR           +RL + LQ+   EKEQL +        A++ KA++       
Sbjct: 767  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826

Query: 434  --------------DELAMETLQEKSQHKEELGAVRLRH--------------------- 458
                          D   +E    K    + +G  +  H                     
Sbjct: 827  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 886

Query: 459  ------EKEVLGVRARYEREL---RELHEDKKR--QEEELRGQIREEKARTRELETLQQT 507
                  ++ V  + A+++  +    +LH D K     + LR  +  +  R+  L T +  
Sbjct: 887  PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDV--QLIRSWSLATFRTL 944

Query: 508  VEELQAQ-VHSMDGAKGWFERRLKEA-----EESLQQQQQ-----EQEEALKQCREQHAA 556
              E Q Q +HS++     F R  ++A     E+ L  +++        + L Q  EQ A 
Sbjct: 945  KPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ 1004

Query: 557  ELKGKE---EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-KKGSAALK 612
            E    +    EL+D+R QLE A E R  H   +   K+  ++    QRI E +K  A ++
Sbjct: 1005 EESRCQRCISELKDIRLQLE-ACETRTVHRLRLPLDKEPAREC--AQRIAEQQKAQAEVE 1061

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELV--LSEMNSPSRTQTGDSSSIS-- 668
             L + +      A+K+    +        RS LE  +  L ++ S S        +IS  
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121

Query: 669  ---SFSYREILRE-----KESSAVPA------------RSLSSSPQAQPPRPAELSDE-- 706
               +    E+LR      KE+ AVPA            + L +  +AQ P    L DE  
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181

Query: 707  ---EVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
               EV E  Q+     + + E+W  E   + LE   A +A+   R+  +        ++ 
Sbjct: 1182 GAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDVRQREL-------EQLG 1233

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDME 814
              +         LG+ L+D  +   E ++ M       + EQL +   L +++E
Sbjct: 1234 RQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  126 bits (317), Expect = 7e-29
 Identities = 205/926 (22%), Positives = 385/926 (41%), Gaps = 138/926 (14%)

Query: 4    ALSEEEFQRMQAQLLELRTNNYQLSDEL-----RKNGVELTSLRQKVAYLDKEFSKAQKA 58
            A  +EEFQ+ + +L +      +L ++L      KN ++L    +    LD E    Q  
Sbjct: 851  ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLI 910

Query: 59   LSKSK---KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ 115
             +K +   K +EV     + E + A+L +++     + S L  +   L   + ++E+E  
Sbjct: 911  KAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 970

Query: 116  QLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDP 175
              +          +G  +D  + +L  E  ALQ+      +    E  K +++++ +   
Sbjct: 971  ATENKVKNLTEELSG--LDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK- 1027

Query: 176  PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESS-KQAETS--RLQEELAKLS 232
                         + ++E   E EK+ +  L    + LE   K A+ S   L+ +  +L 
Sbjct: 1028 ---------LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078

Query: 233  EKLKKKQESFCRLQT---EKETLFNDSRNKIEELQQRKEA------DHKAQLARTQKLQ- 282
            E+LKKK   +C+LQ+   +++TL    + KI+ELQ R E         +A  A+T+K + 
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS 1138

Query: 283  ---QELEAANQSLAE----------LRDQRQGE-----------RLEHAAALRALQDQVS 318
               +ELE  ++ L E          L  +R+ E            L+H A + AL+ + +
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA 1198

Query: 319  IQSADAQEQVEGLLAENNALRT---------------------SLAALEQIQTAKTQELN 357
               A+  EQ++ L      L                       S A LE+I      +L+
Sbjct: 1199 DSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLS 1258

Query: 358  MLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 417
              R +   +   L +   +   L  +  +L+ QL+E     S+L    Q   Q+ E+L +
Sbjct: 1259 EARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318

Query: 418  ELQEARKSAEKRKAMLD------ELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE- 470
            +L+E  K+       L       +L  E  +E+ + K EL     +   EV   R +YE 
Sbjct: 1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1378

Query: 471  ---RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVH----------- 516
               +   EL E KK+  + L+    + +A   +  +L++T + LQ +V            
Sbjct: 1379 DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438

Query: 517  ---SMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
               ++D  +  F++ L E +   ++ Q E E +LK+ R   + EL   +   ++  DQLE
Sbjct: 1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL-STELFKLKNAYEEALDQLE 1497

Query: 574  QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
              + E         +L+QE+ D  + Q     K    L+  ++Q+ LE+       E  +
Sbjct: 1498 TVKREN-------KNLEQEIADLTE-QIAENGKTIHELEKSRKQIELEKADIQLALEEAE 1549

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKES--SAVPA--RSL 689
              L + +++    +L L+++ S    +  +         R   R  E+  SA+ A  RS 
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609

Query: 690  SSSPQAQPPRPAELSDEEV---------AELFQRLAETQQEKWMLEEKVKHLEVSSASMA 740
            + + + +     +L++ E+         AE  + L   Q +   L++   HL+  +    
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ---LKDTQLHLD-DALRGQ 1665

Query: 741  EDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLE 800
            EDL  + AI+E      R ++  A     R+ L    R   K  ++ L + N+++Q +L 
Sbjct: 1666 EDLKEQLAIVE-----RRANLLQAEVEELRATLEQTER-ARKLAEQELLDSNERVQ-LLH 1718

Query: 801  EQLTKNMHLHKDMEVLSQEIVRLSKE 826
             Q T  +H  K +E    ++++L  E
Sbjct: 1719 TQNTSLIHTKKKLET---DLMQLQSE 1741



 Score =  117 bits (292), Expect = 6e-26
 Identities = 161/799 (20%), Positives = 325/799 (40%), Gaps = 147/799 (18%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVA---YLDKEFSKAQKALSKSK 63
            E + +  Q  +L+L  +  QL + L+K   E   L+ KV     L  +F K  K L    
Sbjct: 1057 EGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA-- 1114

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDF---------RLQ------------NSTLMAEFSK 102
            + +E+E  +      +AK   Q  D+         RL+            N    AEF K
Sbjct: 1115 RIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLK 1174

Query: 103  LCSQMEQLEQENQQLKEGAA---GAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYG 159
            L   +E+   +++ +           VA+ G  +D     LQ     L+K  +  +    
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN----LQRVKQKLEKEKSEFKLEID 1230

Query: 160  KEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA 219
              +    +VS+ + +              L ++    E +  E R   E++Q   S    
Sbjct: 1231 DLSSSMESVSKSKAN--------------LEKICRTLEDQLSEARGKNEEIQRSLSELTT 1276

Query: 220  ETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEAD--------- 270
            + SRLQ E  +LS +L++K+    +L   K+     +     +L++  +A          
Sbjct: 1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQS 1336

Query: 271  --HKAQLARTQ---------KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSI 319
              H   L R Q         +LQ+ L  AN  +A+ R + + + ++    L   + +++ 
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396

Query: 320  QSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED 379
            +  D++EQVE +    NA   SL   +Q    + ++L +  E+   LAA L ++Q  ++ 
Sbjct: 1397 RLQDSEEQVEAV----NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452

Query: 380  LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 439
            ++ +      + Q  L A+ +          E   L+ EL + + + E+    LD+L  E
Sbjct: 1453 VLAEWKTKCEESQAELEASLK----------ESRSLSTELFKLKNAYEEA---LDQL--E 1497

Query: 440  TLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTR 499
            T++ ++++ E+          E+  +  +     + +HE +K      R QI  EKA  +
Sbjct: 1498 TVKRENKNLEQ----------EIADLTEQIAENGKTIHELEKS-----RKQIELEKADIQ 1542

Query: 500  -ELETLQQTVEELQAQVH----SMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQH 554
              LE  +  +E  +A++      +   K   +R++ E +E ++Q ++  +  ++  +   
Sbjct: 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602

Query: 555  AAELKGKEE----------ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 604
             AE++ + E          +L ++  QL  A  +    LK + S++ ++KDT    ++  
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT----QLHL 1658

Query: 605  KKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDS 664
                   +DLK QL +  +RA+ LQ  ++++    +      +L   E+           
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQEL----------- 1707

Query: 665  SSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWM 724
              + S    ++L  + +S +  +              +  + ++ +L   + +  ++   
Sbjct: 1708 --LDSNERVQLLHTQNTSLIHTK--------------KKLETDLMQLQSEVEDASRDARN 1751

Query: 725  LEEKVKHLEVSSASMAEDL 743
             EEK K     +A MAE+L
Sbjct: 1752 AEEKAKKAITDAAMMAEEL 1770



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 134/635 (21%), Positives = 268/635 (42%), Gaps = 121/635 (19%)

Query: 1    MAQAL--SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
            +AQ L  SEE+ + + A+   L     +L  E+    V++       A LDK+     K 
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453

Query: 59   LSKSK-----KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQE 113
            L++ K        E+E  L E+  L  +L      F+L+N+     + +   Q+E +++E
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTEL------FKLKNA-----YEEALDQLETVKRE 1502

Query: 114  NQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQG 173
            N+ L++  A             +L    AEN              GK   +         
Sbjct: 1503 NKNLEQEIA-------------DLTEQIAEN--------------GKTIHE--------- 1526

Query: 174  DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 233
                           L +   + E+EK + +L  E+ +     ++A+  R+Q EL ++  
Sbjct: 1527 ---------------LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571

Query: 234  KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ---LARTQKLQQELEAANQ 290
            ++ +K         E E L  + +  +E +Q   +A+ +++   +   +K++ +L     
Sbjct: 1572 EIDRK---IAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628

Query: 291  SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ--- 347
             L+    Q   E L+H   LR++Q Q+     D Q  ++  L     L+  LA +E+   
Sbjct: 1629 QLSHANRQA-AETLKH---LRSVQGQLK----DTQLHLDDALRGQEDLKEQLAIVERRAN 1680

Query: 348  IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQE 407
            +  A+ +EL    EQT     E  ++ AE E L     D N ++Q     N+ L+   ++
Sbjct: 1681 LLQAEVEELRATLEQT-----ERARKLAEQELL-----DSNERVQLLHTQNTSLIHTKKK 1730

Query: 408  IGQEKEQLTQELQEARKSA----EKRKAMLDELAM--ETLQEKSQHKEELGAVRLRHEKE 461
            +  +  QL  E+++A + A    EK K  + + AM  E L+++      L  ++   E+ 
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790

Query: 462  VLGVRARYE-----------RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 510
            V  ++ R +           +++++L    +  E EL G+ ++     + L   ++ V+E
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850

Query: 511  LQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRD 570
            L  Q  S +  K     RL++  + LQ + +  +   ++  EQ  A L     + +  + 
Sbjct: 1851 LTYQ--SEEDRKNVL--RLQDLVDKLQVKVKSYKRQAEEADEQANAHLT----KFRKAQH 1902

Query: 571  QLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEK 605
            +LE+A+E  D     ++ L+ + +D    + ++ +
Sbjct: 1903 ELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 163/769 (21%), Positives = 304/769 (39%), Gaps = 133/769 (17%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEF-------SKAQKAL 59
            EE   + +A +  LR  +     EL +    L  ++QK+     EF       S + +++
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239

Query: 60   SKSKKAQEVEVLLSENEMLQAKLHSQE-----EDFRLQNSTLMAEFSKLCSQMEQLEQEN 114
            SKSK   E      E+++ +A+  ++E      +   Q S L  E  +L  Q+E+ E   
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLR-LQAENTALQKNVAALQE-RYGKEAGKFSAVSEGQ 172
             QL          QA      EL R L+ EN A      ALQ  R+  +  +     E +
Sbjct: 1300 SQLSRSK------QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 1353

Query: 173  GDPPGGPAPTVLAPMPLAEVELKWEME--------KEEKRLLWEQLQGLESSKQAETS-- 222
            G      A +  A   +A+   K+E +        +E K+ L ++LQ  E   +A  +  
Sbjct: 1354 GKAELQRALSK-ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412

Query: 223  --------RLQEELA----------KLSEKLKKKQESFCRL-----------QTEKETLF 253
                    RLQ E+            L+  L KKQ +F ++           Q E E   
Sbjct: 1413 ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472

Query: 254  NDSRNKIEELQQRKEADHKA--QLARTQK----LQQELEAANQSLAE-------LRDQRQ 300
             +SR+   EL + K A  +A  QL   ++    L+QE+    + +AE       L   R+
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532

Query: 301  GERLEHAAALRALQD-------------QVSIQSADAQEQVEGLLAENN----------- 336
               LE A    AL++             ++ ++    + +++  +AE +           
Sbjct: 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592

Query: 337  -ALRTSLAAL--------EQIQTAKTQE--LNMLREQTTGLAAELQQQQAEYEDLMGQKD 385
              + T  +AL        E I+  K  E  LN +  Q +    +  +       + GQ  
Sbjct: 1593 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 1652

Query: 386  DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK--RKAMLDELAMETLQE 443
            D    L ++LR    L EQL  + +    L  E++E R + E+  R   L E  +    E
Sbjct: 1653 DTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNE 1712

Query: 444  KSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELET 503
            + Q         +  +K++     + + E+ +   D +  EE+ +  I +      EL+ 
Sbjct: 1713 RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK 1772

Query: 504  LQQTVEELQAQVHSMDGAKGWFERRLKEAE-----------ESLQQQQQEQEEALKQCRE 552
             Q T   L+    +++      + RL EAE           + L+ + +E E  L+  ++
Sbjct: 1773 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQK 1832

Query: 553  QHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALK 612
            ++   +KG  +  + V++   Q++E+R   L+        ++D VD  ++  K      +
Sbjct: 1833 KNTESVKGLRKYERRVKELTYQSEEDRKNVLR--------LQDLVDKLQVKVKSYKRQAE 1884

Query: 613  DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQT 661
            +   Q +    +  K Q  L++    ++ R+ + E  ++++ + +R  T
Sbjct: 1885 EADEQANAHLTKFRKAQHELEE----AEERADIAESQVNKLRAKTRDFT 1929



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 94/458 (20%), Positives = 200/458 (43%), Gaps = 52/458 (11%)

Query: 403  EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR---LRHE 459
            E  +E+   KE+  +   E  KS  KRK  L+E  +  +QEK+  + ++ A     L  E
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKE-LEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 460  K---EVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTR-ELETLQQTVEELQAQV 515
            +   +++  + + E +++E+ E +   EEE+  ++  +K +   E   L++ +++L+  +
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962

Query: 516  HSMDGAKGWFERRLKEAEESLQQQQQ------EQEEALKQCREQHAAELKGKEEE---LQ 566
              ++  K   E ++K   E L    +       +++AL++  +Q   +L+ +E++   L 
Sbjct: 963  AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022

Query: 567  DVRDQLEQAQEERDCHLKTISSLKQEV---KDTVDGQRILEKKGSAALKDLKRQLHLERK 623
              + +LEQ  E+ +  L+    L+ ++   K  ++G   L ++    L++ K+QL    K
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082

Query: 624  RAD----KLQERLQDILT-----NSKSR------SGLEELVLSEMNSPSRTQTGDSSSIS 668
            + D    +LQ +++D  T       K +        LEE + +E  + ++T+   S    
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS---- 1138

Query: 669  SFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEK 728
               Y   L E       A  ++S+         EL+ +  AE  +   + ++     E  
Sbjct: 1139 --DYARELEELSERLEEAGGVTST-------QIELNKKREAEFLKLRRDLEEATLQHEAM 1189

Query: 729  VKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENL 788
            V  L    A    +L  +  I     +  +++   +    +   L S +  + K    NL
Sbjct: 1190 VAALRKKHADSVAELGEQ--IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK-SKANL 1246

Query: 789  REMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
             ++ + L++ L E   KN  + + +  L+ +  RL  E
Sbjct: 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 84/415 (20%), Positives = 167/415 (40%), Gaps = 62/415 (14%)

Query: 467  ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHS--------- 517
            A  E+E+  + E+ ++ ++EL     + K    +L TL Q   +LQ QV +         
Sbjct: 844  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 518  -----MDGAKGWFERRLKEAEESLQQQQQEQEE--ALKQCREQHAAELKGKEEELQDVRD 570
                 +  AK   E ++KE  E  + +++   E  A K+  E   +ELK   ++L+    
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963

Query: 571  QLEQAQEERDCHLKT----ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ---LHLERK 623
            ++E+ +   +  +K     +S L + +      ++ L++    AL DL+ +   ++   K
Sbjct: 964  KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNK 1023

Query: 624  RADKLQERLQDILTN----SKSRSGLE--------ELVLSEMN----SPSRTQTGDSSSI 667
               KL+++++D+ ++     K R  LE        +L L++ +       + Q  +    
Sbjct: 1024 TKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083

Query: 668  SSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQ------E 721
              F Y ++  + E             +    R  EL +E  AE   R    +Q      E
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARE 1143

Query: 722  KWMLEEKVK--------HLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDR-SG 772
               L E+++         +E++    AE L  +  + E  +    +  ++   H D  + 
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203

Query: 773  LGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKEC 827
            LG  +        +NL+ + +KL+    E   +   L   ME +S+    L K C
Sbjct: 1204 LGEQI--------DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
          Length = 1478

 Score =  125 bits (313), Expect = 2e-28
 Identities = 176/756 (23%), Positives = 318/756 (42%), Gaps = 105/756 (13%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFS-KAQKALSKSKKAQ 66
            EE  R Q+  LE      QL ++ R +   L  L +++A L +E S K Q+A    ++ Q
Sbjct: 418  EEVNRQQSAQLEQLVKELQLKEDARAS---LERLVKEMAPLQEELSGKGQEADQLWRRLQ 474

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGV 126
            E+    S  E   A+L  +++  + +   L  E   L  Q++ LE +  Q+ +  +    
Sbjct: 475  ELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEE 534

Query: 127  AQAGPLVDGELLRLQA-------------------ENTALQKNVAALQERYGKEAGKFSA 167
             +   + D + L  Q                    +N AL    ++LQE +GK   +   
Sbjct: 535  QKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRG 594

Query: 168  VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKR--LLWEQLQGLESSKQA---ETS 222
            + E Q D       +    +  A  EL+ E++    R  LL  +LQ L++  QA     S
Sbjct: 595  LQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRES 654

Query: 223  RLQEELAKLSEK-----------------LKKKQESFCRLQTEKETLFNDS-------RN 258
             +Q  LA L  +                 ++K +E+      EKE +           R 
Sbjct: 655  AIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLRE 714

Query: 259  KIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVS 318
            ++E+ QQ  EA H+   A   + QQ+ +      AE   Q  G   ++ A       +++
Sbjct: 715  EVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEAR------ELA 768

Query: 319  IQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE 378
             Q A +Q Q+E    E   L+  +  L+    A   + + ++ Q +   A L++ +   +
Sbjct: 769  AQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQ 828

Query: 379  DLMGQKDDLN-SQLQESLRANSR---LLEQLQEIGQEKEQ----LTQELQEARKSAEKRK 430
             L  Q + LN + +QE L+ + R   L E+  +  Q++E+    L +EL +A+ S+E+ +
Sbjct: 829  QLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQ 888

Query: 431  AMLDELAMETLQEKSQHKEELG--AVRLRHEKEVLGVRARYERELRELHEDKKRQEEELR 488
                EL  E L   +    ELG     L  EKE   V       ++EL + K+    E  
Sbjct: 889  LEHAEL-QEQLHRANTDTAELGIQVCALTVEKE--RVEEALACAVQELQDAKEAASRERE 945

Query: 489  GQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALK 548
            G  R+     +E E+LQ+ ++  +A   S+ G     + +L +AE+  Q  Q+   + L 
Sbjct: 946  GLERQVAGLQQEKESLQEKLKAAKAAAGSLPG----LQAQLAQAEQRAQSLQEAAHQELN 1001

Query: 549  QCREQHAAE-------LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 601
              + Q +AE       LK   EE + +R QLE+   +     + +  LK    D   G++
Sbjct: 1002 TLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADM--GEK 1059

Query: 602  IL----------------EKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGL 645
            +                 +K+G+A  +DL+R      K   K+QE    +     +R   
Sbjct: 1060 LSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERN 1119

Query: 646  EELVLSEMNSPSRTQTGDSSSISSFSYREILREKES 681
            ++ +L++++  +RT+      +      E+LR+K++
Sbjct: 1120 DQKMLADLDDLNRTKKYLEERLI-----ELLRDKDA 1150



 Score =  102 bits (253), Expect = 2e-21
 Identities = 157/758 (20%), Positives = 320/758 (42%), Gaps = 92/758 (12%)

Query: 46  AYLDKEFSKAQKALSKSKKAQEVEVLLSE---NEMLQAKLHSQEEDFRLQNSTLMAEFSK 102
           AYL K  S++    S      + + ++S    N  L  +     ++ RL+   L     +
Sbjct: 189 AYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQ 248

Query: 103 LCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQA---ENTALQKNVAALQERYG 159
           L  +M+QL++ENQ+L+     A V+Q G  +  E  R +    +N  L   VA LQ+++ 
Sbjct: 249 LRERMQQLDRENQELR-----AAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWE 303

Query: 160 KEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA 219
                 + V E Q         T L  + L   E K E      R L   LQ L    +A
Sbjct: 304 VTQATQNTVKELQ---------TCLQGLELGAAE-KEEDYHTALRRLESMLQPLAQELEA 353

Query: 220 ETSRLQEELAKLSE------KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEA---- 269
               L ++   L+         ++K ++    +  +E + +D+  +++EL ++ +A    
Sbjct: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413

Query: 270 ------DHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD 323
                  ++ Q A+ ++L +EL+    + A L      ERL    A   LQ+++S +  +
Sbjct: 414 RTKVEEVNRQQSAQLEQLVKELQLKEDARASL------ERLVKEMA--PLQEELSGKGQE 465

Query: 324 AQE---QVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDL 380
           A +   +++ LLA  ++    LA L + +  + +E  +L ++   L  +LQ  + +   +
Sbjct: 466 ADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525

Query: 381 MGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMET 440
                DL  Q ++ ++    L +Q   +G  +        E   + EK +A++      +
Sbjct: 526 SQHVSDLEEQKKQLIQDKDHLSQQ---VGMLERLAGPPGPELPVAGEKNEALVP--VNSS 580

Query: 441 LQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRE 500
           LQE     EE    R   E ++   + +   +  EL +  +  E+EL+  +   +    +
Sbjct: 581 LQEAWGKPEE--EQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGK 638

Query: 501 LETLQQTVEELQAQVHSMDGAKGWFE------RRLKEAEESLQQQQQEQEEALKQCREQH 554
           L+ LQ   + LQ +  ++ G+    E      R L +  E+     ++ +EA+K    + 
Sbjct: 639 LQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEK 698

Query: 555 AAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRIL-EKKG------ 607
            A L+ KE E Q +R+++EQ Q+  +   + + +L+ + +       +L  +KG      
Sbjct: 699 EAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGP 758

Query: 608 ---------SAALKDLKRQLHLERKRADKLQERLQDILTNSK----------SRSGLEEL 648
                    +A L   + QL + +    +LQ ++ D+    +          S+  + E 
Sbjct: 759 PTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818

Query: 649 VLSEMNSPSRTQTGDSSSISSFSYREILR--EKESSAVPARSLSSSPQAQPPRPAELSDE 706
           VL E  +  +     + +++    +E+L+  E+E +    R+  +  + +  R  +   E
Sbjct: 819 VLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQ---E 875

Query: 707 EVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
           E+++      E Q E   L+E++      +A +   +C
Sbjct: 876 ELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVC 913



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 142/583 (24%), Positives = 239/583 (40%), Gaps = 61/583 (10%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
            L E + Q +QA    L+     +   L     E  S+R    +L  +   +  A+ K+K+
Sbjct: 634  LLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIR----HLGDQMEASLLAVRKAKE 689

Query: 65   AQEVEVLLSENEMLQAK---LHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGA 121
            A + ++   E  +LQ+K        E+         A   +L +   Q +Q+ Q ++   
Sbjct: 690  AMKAQMAEKE-AILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLT 748

Query: 122  AGAGVAQAGPLVDGELLRL-------QAENTALQKNVAALQERYGKEAGKFSAVSEGQGD 174
            A  G    GP  D E   L       QA+    Q  V  LQ +      K  A  + Q  
Sbjct: 749  AEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDK 808

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                    V + + +AE  L+     E K L+    Q L+   +A      +EL + SE+
Sbjct: 809  --------VQSQLSMAEAVLR-----EHKTLV----QQLKEQNEALNRAHVQELLQCSER 851

Query: 235  LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAE 294
                QE       ++E    + R   EEL Q K +  +AQL   + LQ++L  AN   AE
Sbjct: 852  EGALQEERADEAQQRE---EELRALQEELSQAKCSSEEAQLEHAE-LQEQLHRANTDTAE 907

Query: 295  LRDQR-----QGERLEHA--AALRALQDQVSIQSADAQ---EQVEGLLAENNALRTSLAA 344
            L  Q      + ER+E A   A++ LQD     S + +    QV GL  E  +L+  L A
Sbjct: 908  LGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKA 967

Query: 345  LEQIQTAKTQELNMLREQTTGLAAELQQ-QQAEYEDLMGQKDDLNSQLQESLRANSRLLE 403
             +    A    L  L+ Q        Q  Q+A +++L   K  L++++ +         E
Sbjct: 968  AK----AAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE 1023

Query: 404  QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL 463
            + + +  + E+  ++LQ A ++ EK KA   ++  E L   S H  E  A  LR +KE  
Sbjct: 1024 ECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMG-EKLSCTSNHLAECQAAMLRKDKEGA 1082

Query: 464  GVRARYERELRELHEDKKRQEE-------ELRGQIREEKARTRELETLQQTVEELQAQVH 516
             +R   ER  +EL +   + +E       E+  + R ++    +L+ L +T + L+ ++ 
Sbjct: 1083 ALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLI 1142

Query: 517  SMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELK 559
             +   K    ++    E   QQ+   +E  L      H  + K
Sbjct: 1143 ELLRDKDALWQKSDALE--FQQKLSAEERWLGDTEANHCLDCK 1183


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  124 bits (311), Expect = 4e-28
 Identities = 186/782 (23%), Positives = 332/782 (42%), Gaps = 96/782 (12%)

Query: 20   LRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KAQEVEVLLSENEML 78
            LR    +L + L     E + +  ++  L ++ S+ Q+  SK + K   +E  L E    
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321

Query: 79   QAKLHSQEEDFRLQN-------STLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGP 131
             A L S+     LQ          L A    L +Q+E L+    + +  A+ AG+ +   
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381

Query: 132  LVDGELLRLQAENTALQKNVA-ALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLA 190
                  L+L+ E    ++  A ALQE+   +  +  A+ E             L    LA
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN----------LALLTQTLA 1431

Query: 191  EVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKE 250
            E E       EE   L  Q+Q LE  ++ + + L+     LS  LKK+ +    LQ E+ 
Sbjct: 1432 ERE-------EEVETLRGQIQELEKQREMQKAALE----LLSLDLKKRNQEV-DLQQEQ- 1478

Query: 251  TLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGER--LEHAA 308
                     I+EL++ +       +A  Q+ +Q+L    + + EL   R+ +R  LEH  
Sbjct: 1479 ---------IQELEKCRSVLEHLPMA-VQEREQKLTVQREQIRELEKDRETQRNVLEHQL 1528

Query: 309  ALRALQDQVSI----QSADAQEQVEGL------LAENN-ALRTSLAALEQIQTAKTQELN 357
                 +DQ+      Q  D ++Q+  L      L EN+  +      +++++  +  +  
Sbjct: 1529 LELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV 1588

Query: 358  MLREQTTGL---AAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 414
             L   T  L   + ELQ Q ++  DL      L  +LQE  +      EQ++E+ ++KE 
Sbjct: 1589 ALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH 1648

Query: 415  LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL- 473
            LTQ+L+   +    +K  +  L  +  ++    +E+L  ++L   +   G     +R+L 
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER--GRELTTQRQLM 1706

Query: 474  RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRL---- 529
            +E  E+ K   +  RG +   K   R+ E   + VE  Q  +H +   K   E++L    
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKE---KEVECQQEHIHELQELKDQLEQQLQGLH 1763

Query: 530  -KEAEESLQQQQQEQEEALKQCREQHAAEL-KGKEEELQDVRDQLEQAQEERDCHLKTIS 587
             K  E SL   Q+EQE  + Q + Q A E  + KE+ LQ   D+ ++A  +RD  L+ + 
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ 1823

Query: 588  SLKQE-------VKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQER--------- 631
              +Q+       VK+  D  +   ++    LK+   +L   +++A +L+E          
Sbjct: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQ 1883

Query: 632  -LQDILTNSKSRSGLEELVLSEMNSPSRTQTGD------SSSISSFSYREILREK--ESS 682
             L+++L + ++ S  +E  L  +      Q  +      +   S    + +L+E+  E  
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE 1943

Query: 683  AVPARSLSSSPQAQPPRP-AELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAE 741
            A+ A S SS  Q +  R  AE   E + +    L   +Q      E  + LE S+A++  
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003

Query: 742  DL 743
             L
Sbjct: 2004 SL 2005



 Score =  117 bits (292), Expect = 6e-26
 Identities = 204/932 (21%), Positives = 396/932 (42%), Gaps = 179/932 (19%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q L +E  +R Q +L++L++       EL+    EL++L  +    ++++ K  KAL ++
Sbjct: 254  QELEKEAHERSQ-ELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRET 312

Query: 63   KKAQEVE-VLLSENEMLQAKLHSQEEDFRLQ----------------------------- 92
             +  E     L E+E   ++ ++QEE   LQ                             
Sbjct: 313  VEILETNHTELMEHEASLSR-NAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL 371

Query: 93   NSTLMAEF---------SKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAE 143
            +S++ ++F         + + S + +  Q  Q L++  AG   A         +  LQ +
Sbjct: 372  DSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEA---------VNLLQQQ 422

Query: 144  NTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPL---AEVELKWEMEK 200
            +   ++   AL++R  K  G+   ++ GQ     G   ++     L   A  EL+ ++E 
Sbjct: 423  HDQWEEEGKALRQRLQKLTGERDTLA-GQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481

Query: 201  EEK------------RLLWEQLQGLESSKQAETSRLQEELAKLSEKLK----KKQESFCR 244
             E+            +L  +  QG +  +Q E      E  +L E L     K+ ES   
Sbjct: 482  LEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541

Query: 245  LQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSL-AELRDQRQGER 303
            L T +E L  +S +   EL ++++ +  A LAR ++   EL ++  +L  E+ D R    
Sbjct: 542  LITLREAL--ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA-- 597

Query: 304  LEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQT 363
               A  L AL + +++      +Q+  L  EN ++ + + A EQ + A            
Sbjct: 598  ---AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA------------ 642

Query: 364  TGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEAR 423
              L  +L + +   E L  +   L +QLQ++  A + L   L++I +EKE++ ++L E+R
Sbjct: 643  --LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESR 700

Query: 424  KSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQ 483
               E     L     E L ++++ +EE+ A  ++ ++ ++  +A  E  L+ +  D++  
Sbjct: 701  HQQEAATTQL-----EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755

Query: 484  EEELRGQIREEKARTRELETLQQ-------TVEELQAQVHSMDGAKGWFE---------- 526
             E+L+G    ++     L   QQ       T  +L+ Q+ ++  AK   +          
Sbjct: 756  AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815

Query: 527  ---------------RRLKEAEE----SLQQQQQEQEEALKQCREQ-------HAAELKG 560
                           R+L +AE+    +L+QQ+   E+ + Q RE+       H  EL  
Sbjct: 816  DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875

Query: 561  KEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDG-----QRILEKKGSAALKDL- 614
              E L+  + +LE   +E+   ++ I + ++E +   +      Q   EK+  + L+ L 
Sbjct: 876  ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935

Query: 615  --KRQL-----HLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSI 667
              +++L      LER R D   ++L++  T    ++ L+E    E+   +R    D +++
Sbjct: 936  QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE-AQRELKEAARQHRDDLAAL 994

Query: 668  SSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEE 727
               S   +L++K         L S   AQ      L ++EV E   +L ETQ+   + +E
Sbjct: 995  QEES-SSLLQDKMDLQKQVEDLKSQLVAQDD-SQRLVEQEVQE---KLRETQEYNRIQKE 1049

Query: 728  KVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDEN 787
                LE   AS+   L  K         + R+ V   A    +  L ++ +D+ +   E 
Sbjct: 1050 ----LEREKASLTLSLMEK---------EQRLLVLQEADSIRQQELSALRQDMQEAQGEQ 1096

Query: 788  LREMNKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             +E++ +++ + +E         K+ + L+QE
Sbjct: 1097 -KELSAQMELLRQEV------KEKEADFLAQE 1121



 Score =  116 bits (290), Expect = 1e-25
 Identities = 215/924 (23%), Positives = 390/924 (42%), Gaps = 144/924 (15%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            EEE + ++ Q+ EL         E++K  +EL SL  K    ++E    Q+ + + +K +
Sbjct: 1434 EEEVETLRGQIQELEKQR-----EMQKAALELLSLDLKKR--NQEVDLQQEQIQELEKCR 1486

Query: 67   EV-EVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAG 125
             V E L    +  + KL  Q E  R        + + L  Q+ +LE+++Q ++       
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE------- 1539

Query: 126  VAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLA 185
             +Q G + D +   +  E  AL+     L+E + K   +   + E +G            
Sbjct: 1540 -SQRGQVQDLKKQLVTLECLALE-----LEENHHKMECQQKLIKELEGQRE-------TQ 1586

Query: 186  PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRL 245
             + L  + L  E   +E +    Q+  LES     ++ L  EL +  +++K ++E    L
Sbjct: 1587 RVALTHLTLDLEERSQELQAQSSQIHDLES----HSTVLARELQERDQEVKSQREQIEEL 1642

Query: 246  QTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK---LQQELEAANQSLAE----LRDQ 298
            Q +KE L  D   + +EL  +KE     +  RT++   L+++LE    SL E    L  Q
Sbjct: 1643 QRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ 1702

Query: 299  RQ--GERLEH----AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTA- 351
            RQ   ER E     + A R   + + +   D +++VE      + L+     LEQ     
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762

Query: 352  --KTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDD-LNSQLQESLRANSRLLEQLQEI 408
              K  E ++L  Q       LQQQ  E  +    K+  L SQL E+ RA ++  ++L+ +
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822

Query: 409  GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEK----SQHKEELGAVRLRHEKEVLG 464
             QE++Q   + +  ++ A+  +  L++  M TL+E+      HKE+  A RL  E  V G
Sbjct: 1823 QQEQQQAQGQEERVKEKADALQGALEQAHM-TLKERHGELQDHKEQ--ARRLEEELAVEG 1879

Query: 465  VRAR-YERELRELHEDKKRQEEELRGQIRE--EKARTRELET--LQQTVEELQAQVHSMD 519
             R +  E  L +L  + + QE+ L    ++  E+A+  E+ET  LQ +  + QA +   D
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939

Query: 520  GAKGWFERRLKEAEESLQQQQ--QEQEEALKQCREQHAAELKGKEEEL------------ 565
                  E    E++ S  Q++  + + EAL++   +  A L+GKE+ L            
Sbjct: 1940 QE---LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEA 1996

Query: 566  --------------------------------QDVR-----DQLEQAQEERDCHLK---- 584
                                            QD+R      QL+QA  +RD  L+    
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056

Query: 585  ----TISSLKQEVKDTV--DGQRILEKKGSAALKDLKRQLH-LERKRADKLQERLQDILT 637
                   SL Q V++ +  + Q + +++    ++ L + +  L+   A K QE L+  L 
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE--LR 2114

Query: 638  NSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREI------LREKESSAVPARSLSS 691
             ++ R+ LE L  S   SP   Q+    S+     RE+      LR+ E+  +  R  + 
Sbjct: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQ 2174

Query: 692  --SPQAQPPRPAELSDEEVAELFQ-RLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSA 748
              +      + +  S +EVA   Q  + E   E+  L+++   LE++  ++ ++      
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDE---LELTRRALEKERLHSPG 2231

Query: 749  IIETYVMDSRIDVSVAAGHTD----RSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
               T  + SR +  V  G             + +   +   E+L++   +L+        
Sbjct: 2232 ATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQR 2291

Query: 805  KNMHLHKDMEVLSQEIVRLSKECV 828
             N+ L   +E + +E  +L +E +
Sbjct: 2292 HNVQLRSTLEQVERERRKLKREAM 2315



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 211/963 (21%), Positives = 395/963 (41%), Gaps = 163/963 (16%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            +A  E+E  +++ +  + R+ + Q   EL K    L SL ++   L+    + Q  +   
Sbjct: 848  KAAHEKEVNQLREKWEKERSWHQQ---ELAK---ALESLEREKMELEMRLKEQQTEMEAI 901

Query: 63   KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMA--EFSKLCSQMEQLEQEN--QQLK 118
            +  +E E   +E+ + Q +L +++E   L  + L    E +    Q+E+L Q+   Q+LK
Sbjct: 902  QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961

Query: 119  EGA-----------AGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSA 167
            E             A   + +A      +L  LQ E+++L ++   LQ++      +  A
Sbjct: 962  EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021

Query: 168  VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL-LWEQLQGLESSKQAETSRLQE 226
              + Q          +        ++ + E EK    L L E+ Q L   ++A++ R Q+
Sbjct: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR-QQ 1080

Query: 227  ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK-----------IEELQ------QRKEA 269
            EL+ L + +++ Q     L  + E L  + + K           +EEL+      Q+  A
Sbjct: 1081 ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140

Query: 270  DHKAQLARTQKLQQELEAANQSLAELR-DQRQGERLEHAAALRALQDQVSIQSA------ 322
               AQ A+  +LQ  L +    L  L  +Q+ G + +  A L +L    ++Q A      
Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS--ALQQALGSVCE 1198

Query: 323  ---------DAQEQVEGLLAENNALRTS------LAALEQIQTAKT-----QELNMLREQ 362
                     D+   V GL  + N  R+       L AL     A       Q+L   ++ 
Sbjct: 1199 SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQT 1258

Query: 363  TTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEA 422
               L  ++Q+ +    D   +K  ++++LQ+  R  S+  E+  +   ++  L  EL E 
Sbjct: 1259 RDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMEL 1318

Query: 423  RKSAEKRKAMLDELAMETLQEKSQH------KEELGAVRLRHEKEVLGVRAR------YE 470
             ++    ++ L    ++ ++ + +       KE L A     +  V+  RA+       E
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE 1378

Query: 471  RELRELHEDKKRQEEEL-----RGQIREEKA-----------------------RTRELE 502
             +LR      K + EE+     R Q  +E+                        R  E+E
Sbjct: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE 1438

Query: 503  TLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCR---EQHAAELK 559
            TL+  ++EL+ Q      A       LK+  + +   QQEQ + L++CR   E     ++
Sbjct: 1439 TLRGQIQELEKQREMQKAALELLSLDLKKRNQEV-DLQQEQIQELEKCRSVLEHLPMAVQ 1497

Query: 560  GKEEELQDVRDQLEQAQEERDCHLKTISS--LKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
             +E++L   R+Q+ + +++R+     +    L+ E KD    Q I  ++G   ++DLK+Q
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKD----QMIESQRGQ--VQDLKKQ 1551

Query: 618  LHLERKRADKLQERLQDILTNSK-----------SRSGLEELVL-----SEMNSPSRTQT 661
            L      A +L+E    +    K            R  L  L L     S+      +Q 
Sbjct: 1552 LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611

Query: 662  GDSSSISSFSYREILREKESSAVPARSLSSSPQAQP---PRPAELSDEEVAELFQRL--- 715
             D  S S+   RE L+E++      R      Q Q     +  E  D+E+    +R+   
Sbjct: 1612 HDLESHSTVLARE-LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670

Query: 716  --AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGL 773
                T+Q K +LEE ++ +++S      +L  +  +++    + +       G  +   L
Sbjct: 1671 EDQRTRQTK-ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL 1729

Query: 774  GSVLRDLVKPGD---ENLREMNKKLQNMLEEQLTKNMHLHKDMEVLS-------QEIVRL 823
              +LRD  K  +   E++ E+ ++L++ LE+QL     LH+ +   S       QEIV L
Sbjct: 1730 --ILRDKEKEVECQQEHIHEL-QELKDQLEQQL---QGLHRKVGETSLLLSQREQEIVVL 1783

Query: 824  SKE 826
             ++
Sbjct: 1784 QQQ 1786



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 201/913 (22%), Positives = 374/913 (40%), Gaps = 146/913 (15%)

Query: 12   RMQAQLLELRTNNYQLSDE---LRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEV 68
            R +  + EL ++   L  E   LR   V+L++L + +A            L K    Q++
Sbjct: 572  RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA------------LDKVGLNQQL 619

Query: 69   EVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQ 128
              L  EN+ + +++ + E+      + L  + ++   + E L ++N  L+     A   +
Sbjct: 620  LQLEEENQSVCSRMEAAEQ----ARNALQVDLAEAEKRREALWEKNTHLEAQLQKA--EE 673

Query: 129  AGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMP 188
            AG  +  +L  +Q E   +QK ++  + +      +   + +         A  V     
Sbjct: 674  AGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733

Query: 189  L----AEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCR 244
            L    A +E++ +  + +++ L EQLQGL S+K+   S L E   + S     K +   +
Sbjct: 734  LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793

Query: 245  LQT---EKETLFNDSRN-KIEELQQRKEADHKA-----QLARTQK-----LQQELEAANQ 290
            +QT    KE +  + R  K+E   +R +A+ +      QLA+ ++     L+Q+  A  +
Sbjct: 794  IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853

Query: 291  SLAELRDQRQGERLEH----AAALRALQDQ---VSIQSADAQEQVEGLLAENNALRTSL- 342
             + +LR++ + ER  H    A AL +L+ +   + ++  + Q ++E + A+    RT   
Sbjct: 854  EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913

Query: 343  AALEQIQTAKTQE----LNMLREQTTGLAAELQQQQAEYEDLMGQK-------DDLNSQL 391
            +AL Q+Q    +E    L  L +    LA   QQ +   +D+  QK         L +QL
Sbjct: 914  SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQL 973

Query: 392  QESLRANSRLLEQ----LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 447
            QE+ R       Q    L  + +E   L Q+  + +K  E  K+ L        Q+ SQ 
Sbjct: 974  QEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL------VAQDDSQR 1027

Query: 448  K-EELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQ 506
              E+    +LR  +E   ++   ERE   L      +E+ L      +  R +EL  L+Q
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087

Query: 507  TVEELQAQVHSMDGAKGWFERRLKEAE-ESLQQQQQ--EQEEALKQCREQHAAELKGKEE 563
             ++E Q +   +        + +KE E + L Q+ Q  E+ EA     +Q  A L  +E 
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEA 1147

Query: 564  E-------LQDVRDQLEQA--------QEERDCHLKTISSLKQEVKDTV----------- 597
            +       L+    QLE          Q +    L ++ S  Q+   +V           
Sbjct: 1148 KAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG 1207

Query: 598  -------------DGQRILEKKG-----------SAALKDLKRQLHLERKRADKLQERLQ 633
                         +G R L K+G           ++AL  L + L   ++  D L++++Q
Sbjct: 1208 DSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQ 1267

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
             +          +  V +E+    R  + +    S +  ++     ES  +      +S 
Sbjct: 1268 KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQ--NSLESELMELHETMASL 1325

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
            Q++  R AEL         QR+ E Q E+ +L+   ++L     +  E L  ++A++E  
Sbjct: 1326 QSR-LRRAEL---------QRM-EAQGERELLQAAKENL----TAQVEHL--QAAVVEAR 1368

Query: 754  VMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDM 813
               S   +      T RS L      L     E+ RE  + LQ   E ++ +   L +++
Sbjct: 1369 AQASAAGILEEDLRTARSAL-----KLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423

Query: 814  EVLSQEIVRLSKE 826
             +L+Q +    +E
Sbjct: 1424 ALLTQTLAEREEE 1436



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 145/634 (22%), Positives = 259/634 (40%), Gaps = 76/634 (11%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            E+E   +Q QL E R        EL++              L  +  +AQ+AL++  + Q
Sbjct: 1777 EQEIVVLQQQLQEAREQG-----ELKEQS------------LQSQLDEAQRALAQ--RDQ 1817

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLK----EGAA 122
            E+E L  E +  Q +    +E        L      L  +  +L+   +Q +    E A 
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877

Query: 123  GAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPT 182
                 QA   V G+L   +AE+   +K + ALQ++  ++A +    +    D        
Sbjct: 1878 EGRRVQALEEVLGDL---RAESREQEKALLALQQQCAEQAQEHEVETRALQDS------W 1928

Query: 183  VLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE-- 240
            + A   L E + + E  + E +    Q    E + +A    LQE L K    L+ K++  
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQ----EEAARARAEALQEALGKAHAALQGKEQHL 1984

Query: 241  ------------SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK-LQQELEA 287
                        S   LQ   +     SR ++EE  + +E + + Q  R Q+ +QQ  +A
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSR-QLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043

Query: 288  ANQSLAELRDQRQGER-LEHAAALRA----LQDQVSIQSADAQEQVEGLLAENNALRTSL 342
              Q   ELR Q++ E+ LE + A R     +Q++ ++     +E++ GL      L+ +L
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103

Query: 343  AALEQ--IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSR 400
            A  EQ  ++  +TQ+ N L       A     + +  E+   + D L  +LQ  L     
Sbjct: 2104 AQKEQEILELRETQQRNNLE------ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157

Query: 401  LLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAM-------ETLQEKSQHKEELGA 453
             L Q +    E  +  Q+L  +    +   + L E+AM       E   E+ + ++EL  
Sbjct: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217

Query: 454  VRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQA 513
             R   EKE L               ++  Q  E+ G   E      E ++ +Q +E LQ 
Sbjct: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277

Query: 514  QVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQC-REQHAAELKGKEEELQDVRDQL 572
             V  ++  +   +R   +   +L+Q ++E+ +  ++  R   A  L+  +        Q 
Sbjct: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337

Query: 573  EQAQEERDCHLKTISSLKQEVKDTVDGQRILEKK 606
             + Q+  D   K ++ L++EV   +  Q  LE+K
Sbjct: 2338 GRGQKNSDA--KCVAELQKEVV-LLQAQLTLERK 2368



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 154/707 (21%), Positives = 266/707 (37%), Gaps = 124/707 (17%)

Query: 213 LESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKI-------EELQQ 265
           LE    A   ++ E  A    KLK  QE+    Q  + TL    + K+       +EL++
Sbjct: 20  LEEQVLALQQQMAENQAASWRKLKNSQEA----QQRQATLVRKLQAKVLQYRSWCQELEK 75

Query: 266 RKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA----LRALQDQVSIQS 321
           R EA       R + +++     ++ L  L +++Q  R E  A     LR   ++  + +
Sbjct: 76  RLEATGGPIPQRWENVEEP--NLDELLVRLEEEQQ--RCESLAEVNTQLRLHMEKADVVN 131

Query: 322 ADAQEQVEGLLAENNALRTSLAALEQIQTAKTQE-------------LNMLREQTTGLAA 368
              +E VE L  + +  R  L   E  Q    QE             L++ RE  T    
Sbjct: 132 KALREDVEKLTVDWSRARDELMRKES-QWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRH 190

Query: 369 ELQQQQAEYEDLMGQKDD--------LNSQLQESLRANSR------------------LL 402
            L+ + A   DLM  K +        L   L+ ++ A SR                  LL
Sbjct: 191 FLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL 250

Query: 403 EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME--TLQEKSQHKEELGAVRLRHEK 460
            + QE+ +E  + +QEL + +   +  KA L +   E   L  +SQ + E       +EK
Sbjct: 251 AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE------DYEK 304

Query: 461 EVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL--ETLQQTVEE----LQAQ 514
            +  +R   E  L   H +    E  L    +EEK   +++  +  Q  VEE     Q  
Sbjct: 305 MIKALRETVE-ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS 363

Query: 515 VH--SMDGAKGWFER------------------RLKEAEESLQQQQQEQEEALKQCREQH 554
            H  S++     F +                  R ++A + L+QQ    +EA+   ++QH
Sbjct: 364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH 423

Query: 555 AAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDL 614
                  EEE + +R +L++   ERD        L+ EV      + +L+K    A ++L
Sbjct: 424 ----DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK----AREEL 475

Query: 615 KRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYRE 674
           ++QL +  + A +L+    ++     S  G +E    E++   R +      +     ++
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQ 535

Query: 675 ILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEV 734
              E  S  +  R    S   +     EL  +E  E+   LA  +Q    L      L+ 
Sbjct: 536 --SESLSELITLREALESSHLE----GELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589

Query: 735 SSASMAEDLCRKSAIIETYVMD---------------SRIDVSVAAGHTDRSGLGSVLRD 779
             A +     + SA+ E   +D                 +   + A    R+ L   L +
Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649

Query: 780 LVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
             K   E L E N  L+  L++       L  D+  + +E   + K+
Sbjct: 650 AEK-RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 148/674 (21%), Positives = 269/674 (39%), Gaps = 106/674 (15%)

Query: 189 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF------ 242
           LAEV  +  +  E+  ++ + L+        + SR ++EL +   + + +QE F      
Sbjct: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172

Query: 243 -----CRLQTEKETL---FNDSRNKIEELQQRKEADH----------------------- 271
                  L  E  T    F + ++  +      +A+H                       
Sbjct: 173 EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232

Query: 272 ----------KAQL----ARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQV 317
                      AQL    A+TQ+L++E    +Q L +L+ Q   E+ E       LQD+V
Sbjct: 233 NGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAE-------LQDRV 285

Query: 318 SIQSA---DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQ 374
           +  SA    +Q+Q E       ALR ++  LE   T   +    L          LQQ  
Sbjct: 286 TELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVI 345

Query: 375 AEYEDLMGQKDD---LNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKA 431
            +   +M ++ D     S  + SL  +S +  Q      + +   + L   R    +R+ 
Sbjct: 346 KDITQVMVEEGDNIAQGSGHENSLELDSSIFSQF-----DYQDADKALTLVRSVLTRRRQ 400

Query: 432 MLDELAMETLQEKSQHKEELGAVRLRH---EKEVLGVRARYERELRELHEDKKRQEEELR 488
            + +L     Q+ +  +E +  ++ +H   E+E   +R R ++   E  +    Q  +L+
Sbjct: 401 AVQDLR----QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQTVDLQ 455

Query: 489 GQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERR----LKEAEESLQQQQQEQE 544
           G++    + ++E E LQ+  EEL+ Q+  ++  + W  RR    L+   +S Q Q++EQ+
Sbjct: 456 GEV---DSLSKERELLQKAREELRQQLEVLE-QEAWRLRRVNVELQLQGDSAQGQKEEQQ 511

Query: 545 EALKQC---REQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 601
           E L      RE+    L G E +  +   +L   +E  +        L+QE  +      
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571

Query: 602 ILEK---KGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSP-- 656
             E+   + S++   LK ++   R  A KL   L + L   K     + L L E N    
Sbjct: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKL-SALNEALALDKVGLNQQLLQLEEENQSVC 630

Query: 657 SRTQTGDSSS-------ISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSD--EE 707
           SR +  + +          +   RE L EK +       L  + +A     A+L D  EE
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHL--EAQLQKAEEAGAELQADLRDIQEE 688

Query: 708 VAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMD-SRIDVSVAAG 766
             E+ ++L+E++ ++     +++ L   +    E L R     E  V + + ++V + A 
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748

Query: 767 HTDRSGLGSVLRDL 780
             DR  L   L+ L
Sbjct: 749 ERDRQDLAEQLQGL 762



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 78/405 (19%), Positives = 151/405 (37%), Gaps = 55/405 (13%)

Query: 20   LRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA---LSKSKKAQEVEVLLSENE 76
            LR    ++ D+  +   ++  L+Q +A  D+E    Q+    L KS   +  E ++ E +
Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQ 2078

Query: 77   MLQAKLHSQEEDFR-LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDG 135
             L  +   +EE+ R L  S    + +    + E LE    Q +        +     ++ 
Sbjct: 2079 NLGQE--REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136

Query: 136  ELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEV--- 192
            + L+L +    LQ+ +  LQ    +   +     E   D     A T  +   L EV   
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196

Query: 193  -------------ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE------ 233
                          L+ E+E   + L  E+L    ++  AE     E+  +L E      
Sbjct: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256

Query: 234  --------------KLKKKQESFCRLQTEKETLFNDS---RNKIEELQQRKEADHKAQLA 276
                          +L+  Q++  RL+ ++  L   +   R+ +E++++ +    +  + 
Sbjct: 2257 EPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMR 2316

Query: 277  RTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD---AQEQVEGLLA 333
              Q    E+  A  S    +D R G++   A  +  LQ +V +  A     ++Q +  + 
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGR-GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYIT 2375

Query: 334  ENNALRTSLAALEQ------IQTAKTQELNMLREQTTGLAAELQQ 372
             +      LA L        +  A+  E  +L  +T  L   L Q
Sbjct: 2376 RSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  122 bits (306), Expect = 1e-27
 Identities = 176/860 (20%), Positives = 376/860 (43%), Gaps = 90/860 (10%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            E +   +Q  L   R +  +   + R  G EL +L+ ++   D   S A +   +SK+ Q
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE--DTLDSTAAQQELRSKREQ 1167

Query: 67   EVEVLLSENEMLQAKLH-SQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAG 125
            EV +L    E  +AK H +Q ++ R ++S  + E   L  Q+EQ ++    L E A    
Sbjct: 1168 EVNILKKTLEE-EAKTHEAQIQEMRQKHSQAVEE---LAEQLEQTKRVKANL-EKAKQTL 1222

Query: 126  VAQAGPLVDGELLRLQAENTALQKN---VAALQERYGKEAGKFSAVSEGQGDPPGGPAPT 182
              + G L +   + LQ +  +  K     A LQE   K        +EG+          
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK-------FNEGE---------- 1265

Query: 183  VLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF 242
                  LA+   K ++E +    L  Q     S    + S L+ +L    E L+++    
Sbjct: 1266 -RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

Query: 243  CRLQTEKETLFNDSRNKIEELQQRKEADHK---------AQLARTQKLQQE----LEAAN 289
              L T+ + + ++  +  E+L++ +EA H          AQ+A  +K  ++    LE A 
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384

Query: 290  QSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQ 349
            +   +L+   +G    H   + A  D++       Q++++ LL + +  R S   LE+ Q
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKV-AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443

Query: 350  TAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL-------RANSRLL 402
                Q L   +  +   A E  + +AE  +   +   L   L+E++       R N +  
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503

Query: 403  EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL--AMETLQEKSQHKEELGAVRLRHEK 460
             +++++   K+ + + + E  KS    +  ++E+   +E L+++ Q  E+    +LR E 
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED---AKLRLEV 1560

Query: 461  EVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRE-----------LETLQQTVE 509
             +  ++A++ER+L+   E  + ++++L  Q+RE +A   +            + L+  ++
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 510  ELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVR 569
            +L+A + S +  +    ++L++ +  ++   +E ++  +  RE+  A+ K  E++L+ + 
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT-RASREEILAQAKENEKKLKSME 1679

Query: 570  DQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQ 629
             ++ Q QEE     +     +QE  +  D       KG+ AL++ KR+L     R  +L+
Sbjct: 1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE-KRRL---EARIAQLE 1735

Query: 630  ERLQDILTNSK---SRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPA 686
            E L++   N++    R     L + ++N+    +   +   +  + +++ R+ +   V  
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQK-NENARQQLERQNKELKVKL 1794

Query: 687  RSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRK 746
            + +  + +++        + ++A+L ++L    +E+    ++V+  E           +K
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE-----------KK 1843

Query: 747  SAIIETYVMDSRIDVSVAAGHTDRSG--LGSVLRDLVKPGDENLR--EMNKKLQNMLEEQ 802
               +   V D R +        D++   L  + R L +  +E  R     +KLQ  LE+ 
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903

Query: 803  LTKNMHLHKDMEVLSQEIVR 822
                  +++++  L  ++ R
Sbjct: 1904 TETADAMNREVSSLKNKLRR 1923



 Score =  121 bits (304), Expect = 2e-27
 Identities = 203/920 (22%), Positives = 382/920 (41%), Gaps = 141/920 (15%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYL-------DKEFSKAQK 57
            L+ + F + Q QL  ++      +  L+    +   L  KV  L       ++  +K ++
Sbjct: 794  LARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEE 853

Query: 58   ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQ----E 113
             +   +K    E  L+E E LQ++L +++   + Q   L AE ++LC++ E+L      +
Sbjct: 854  LVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ---LQAE-TELCAEAEELRARLTAK 909

Query: 114  NQQLKEGAAG--AGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEG 171
             Q+L+E      A V +     +     LQAE   +Q+N+  L+E+  +E      +   
Sbjct: 910  KQELEEICHDLEARVEEE----EERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ-- 963

Query: 172  QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL 231
                           +     E K +  +EE+ +L +Q   L   K+    R+ E    L
Sbjct: 964  ---------------LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008

Query: 232  SEKLKKKQESFCRLQTEKETLFND----------SRNKIEELQQRKEADHKAQLARTQKL 281
            +E+ ++K +S  +L+ + E +  D           R ++E+ +++ E D      +  +L
Sbjct: 1009 TEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067

Query: 282  QQELEAANQSLAELRDQRQG--ERLEHAAA--------LRALQDQVSIQSAD-------- 323
            Q ++      LA+  ++ Q    R+E  AA        +R L+ Q+S    D        
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127

Query: 324  --AQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLM 381
              A++Q   L  E  AL+T L       TA  QEL   REQ   +  +  +++A+  +  
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLD-STAAQQELRSKREQEVNILKKTLEEEAKTHE-- 1184

Query: 382  GQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETL 441
                   +Q+QE  + +S+ +E+L E  ++ +++   L++A+++ E  +  L       L
Sbjct: 1185 -------AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237

Query: 442  QEK--SQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKAR-- 497
            Q K  S+HK +    +L+  +       R   EL +     + + + + G + +  ++  
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297

Query: 498  --TRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEE---SLQQQQQEQEEALKQCRE 552
              T++   L+  +++ Q  +   +  K     +LK+ E+   S ++Q +E+EEA     +
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357

Query: 553  QHA---AELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEK---K 606
            Q A   A++   +++++D    LE A+E +    K +  L Q  ++ V     LEK   +
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417

Query: 607  GSAALKDLKRQLHLERKRA---DKLQERLQDILTNSKSRS-------------------- 643
                L DL   L  +R+ A   +K Q++   +L   K+ S                    
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477

Query: 644  ------GLEELV-----LSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSS 692
                   LEE +     L  +N   RT+  D  S S     + + E E S    R+L   
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMS-SKDDVGKSVHELEKS---KRALEQQ 1533

Query: 693  PQAQPPRPAELSDEEVAELFQRL---AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAI 749
             +    +  EL DE  A    +L      Q  K   E  ++  +  S    + L R+   
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593

Query: 750  IETYVMDSRIDVSVAAGHTDRSGLGSVLRDL---VKPGDENLREMNKKLQNMLEEQLTKN 806
            +E  + D R   S+A     R  L   L+DL   +   ++N  E  K+L+  L+ Q+   
Sbjct: 1594 MEAELEDERKQRSMAV--AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQMKDC 1650

Query: 807  MHLHKDMEVLSQEIVRLSKE 826
            M    D     +EI+  +KE
Sbjct: 1651 MRELDDTRASREEILAQAKE 1670



 Score =  100 bits (250), Expect = 4e-21
 Identities = 150/688 (21%), Positives = 284/688 (41%), Gaps = 85/688 (12%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
            ++E  Q    Q L L T   Q+ DE      +L    +    L+K+ +     ++  KK 
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372

Query: 66   QEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGA 124
             E  V  L   E ++ KL    E    ++   +A + KL     +L+QE   L       
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL------- 1425

Query: 125  GVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVL 184
                   LVD +  R  A N  L+K      +   +E    +  +E +            
Sbjct: 1426 -------LVDLDHQRQSACN--LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476

Query: 185  APMPLAE-----VELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 239
              + LA      +E K E+E+  K+   E ++ L SSK        +++ K   +L+K +
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTE-MEDLMSSK--------DDVGKSVHELEKSK 1527

Query: 240  ESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQR 299
             +        E    + + ++EEL+   +A   A+L     LQ       + L    +Q 
Sbjct: 1528 RAL-------EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580

Query: 300  QGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNML 359
            + ++ +    +R ++ ++     D ++Q    +A    L   L  LE    A     N  
Sbjct: 1581 EEKKKQLVRQVREMEAELE----DERKQRSMAVAARKKLEMDLKDLE----AHIDSANKN 1632

Query: 360  REQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQEL 419
            R++      +L++ QA+ +D M + DD  +  +E L       ++L+ +  E  QL +EL
Sbjct: 1633 RDEA---IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689

Query: 420  QEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR----- 474
              A ++  + +   DELA E      +     GA+ L  ++ +    A+ E EL      
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGK-----GALALEEKRRLEARIAQLEEELEEEQGN 1744

Query: 475  -ELHEDKKR----QEEELRGQIREEKARTRELETLQQTVE----ELQAQVHSMDG-AKGW 524
             EL  D+ +    Q +++   +  E++  ++ E  +Q +E    EL+ ++  M+G  K  
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804

Query: 525  F-------ERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQE 577
            +       E ++ + EE L  + +E++ A KQ R     +LK    ++ D R   EQ ++
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE-KKLKDVLLQVDDERRNAEQYKD 1863

Query: 578  ERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILT 637
            + D     +  LK+++++  +      ++ +A+ + L+R+L    + AD +   +   L 
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEE----AQRANASRRKLQRELEDATETADAMNREVSS-LK 1918

Query: 638  NSKSRSGLEELVLSEMNSPSRTQTGDSS 665
            N   R  L  +V   M   +R   GD S
Sbjct: 1919 NKLRRGDLPFVVPRRM---ARKGAGDGS 1943


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score =  122 bits (306), Expect = 1e-27
 Identities = 160/674 (23%), Positives = 287/674 (42%), Gaps = 102/674 (15%)

Query: 199  EKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKE---TLFND 255
            E+E  R   E+L+   + K  E S LQ+ L +   +L+K  E   +++ E+E   T   D
Sbjct: 643  ERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRD 702

Query: 256  SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL-------RDQRQGERLEHAA 308
             ++++ E+    ++  +++      L +EL  A Q L +L        D  +    E  A
Sbjct: 703  LQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762

Query: 309  ALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAA 368
               AL+++VS    +  +  E   AE  ALR S+    +         N   +   G   
Sbjct: 763  LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822

Query: 369  ELQQQQAEYEDLMGQKDDLN---SQLQESL--------RANSRLLEQLQEIGQEKEQLTQ 417
             ++  Q E E L G+ ++L    +QLQ  +        +A   L +   EI Q +E L  
Sbjct: 823  RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882

Query: 418  ELQEARKSAEKRKAMLDELAM----------------ETLQEKSQHKEELGAVR--LRHE 459
              +E +++   R+A+ +EL                  E L+E+S+ KE+L  ++  + +E
Sbjct: 883  ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENE 942

Query: 460  KEVLGVRA-RYERELRELHEDKKRQEEELRGQIREEKARTR-ELETLQQTVEE--LQAQV 515
            +  LG    + ++E+ ++ E  +    EL+ Q+ E K + R EL  +Q+ ++E  L+A+ 
Sbjct: 943  RWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEK 1002

Query: 516  HSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQA 575
              +   K   E RL E  E L+  Q+ Q+EAL +                   R  LEQ 
Sbjct: 1003 SRLTAMKMQDEMRLME--EELRDYQRAQDEALTK-------------------RQLLEQT 1041

Query: 576  QEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDI 635
             ++ +  L+  S LK       D +  L K+    +  L+ +L  ER  +D L ER+   
Sbjct: 1042 LKDLEYELEAKSHLK-------DDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI--- 1091

Query: 636  LTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPAR--SLSSSP 693
               S+SR  +E+L    +   +  Q  +   IS         E+++  + +R   L  S 
Sbjct: 1092 ---SRSREQMEQLRNELLQERAARQDLECDKISL--------ERQNKDLKSRIIHLEGSY 1140

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETY 753
            ++         +  +AEL  RL   ++++  L+   + LE           RK   +   
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLE-----------RKVKELVMQ 1189

Query: 754  VMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDE--NLREMNKKLQNMLEEQLTKNMHLHK 811
            V D  + ++          L ++ R + +  +E   L    KKLQ  LEEQ+  N HL  
Sbjct: 1190 VDDEHLSLTDQKDQLSLR-LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248

Query: 812  DMEVLSQEIVRLSK 825
             +  + +++ RL K
Sbjct: 1249 QLNSMKKDL-RLKK 1261



 Score =  101 bits (252), Expect = 3e-21
 Identities = 148/675 (21%), Positives = 283/675 (41%), Gaps = 123/675 (18%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDE--------------LRKNGVELTSLRQK-------V 45
            +EE +RM+A L ELR+ + +  +E              LRKN  EL  ++ +       +
Sbjct: 641  KEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEI 700

Query: 46   AYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAK---------LHSQEEDFRLQNSTL 96
              L  + S+    L  +K++++ E      E+LQAK            QE+  R +   L
Sbjct: 701  RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760

Query: 97   MAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQE 156
             A    L  ++   +QE  +LKE              D EL  L+       KNV  L  
Sbjct: 761  TALKGALKEEVSSHDQEMDKLKE------------QYDAELQALRESVEEATKNVEVLAS 808

Query: 157  RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESS 216
            R        S  SE         A T +    L E   K +   EE      QLQ     
Sbjct: 809  R--------SNTSEQD------QAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIED 854

Query: 217  KQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSR---NKIEELQQRKEADHKA 273
             + + ++ +E L K   ++++ +E+    + E++   +  R   N++E  Q       + 
Sbjct: 855  LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE 914

Query: 274  QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLA 333
            Q   ++KL++E E   Q L  L+++ + ER      +  LQ ++    AD  E       
Sbjct: 915  QKQLSEKLKEESEQKEQ-LRRLKNEMENERWHLGKTIEKLQKEM----ADIVE------- 962

Query: 334  ENNALRTSLAALE-QIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDD---LNS 389
               A RTS   L+ Q+   K +    L E    L  +  + +      M  +D+   +  
Sbjct: 963  ---ASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019

Query: 390  QLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKE 449
            +L++  RA    L + Q + Q  + L  EL+      + R  ++ ++  +  Q + + +E
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079

Query: 450  ELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELE----TLQ 505
            E      R+  ++L  R    RE          Q E+LR ++ +E+A  ++LE    +L+
Sbjct: 1080 E------RNNSDLLSERISRSRE----------QMEQLRNELLQERAARQDLECDKISLE 1123

Query: 506  QTVEELQAQV--------HSMDGAKGWFERRLKEAEESLQQQQQEQ-------------- 543
            +  ++L++++         S +G     E R+ E E+ L+ +++++              
Sbjct: 1124 RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKV 1183

Query: 544  EEALKQCREQHAAELKGKEE---ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600
            +E + Q  ++H +    K++    L+ ++ Q+E+A+EE D    +   L++E+++ +D  
Sbjct: 1184 KELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMN 1243

Query: 601  RILEKKGSAALKDLK 615
              L+ + ++  KDL+
Sbjct: 1244 EHLQGQLNSMKKDLR 1258



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 146/729 (20%), Positives = 304/729 (41%), Gaps = 99/729 (13%)

Query: 155  QERYGKEA-GKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL 213
            QER GK++ G+  A  + QG   G        P P  + ++      +E  ++     G 
Sbjct: 432  QERRGKQSVGRTFA--KLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGA 489

Query: 214  ESSKQAE------TSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDS--RNKIEELQQ 265
            +S K+ E      T  LQ      S     K+ S     +   T       + + E  QQ
Sbjct: 490  QSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQ 549

Query: 266  RKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQ 325
              E   K  L    K   E    N    + +     E+++   +  A   Q + Q+ ++ 
Sbjct: 550  TNEETAKQILYNYLK---EGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNST 606

Query: 326  EQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 385
             +V+ LL + + L   +A L++    + +    ++E+   + A L++ ++++ + + +  
Sbjct: 607  SEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENS 666

Query: 386  DLNSQLQESLRANSRLLEQLQEIGQEKEQ--------------LTQELQEARKSAEKRK- 430
             L  +L+ES     + LE+L ++  E+EQ              +  EL  A++S ++ K 
Sbjct: 667  TLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKG 726

Query: 431  AMLDEL--AMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL----RELHEDKKRQE 484
            A+++EL  A + LQ+    KEE   +  + E+E+  ++   + E+    +E+ + K++ +
Sbjct: 727  ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD 786

Query: 485  EELRGQIREEKARTRELETL--------------QQTVEELQAQVHSMDGAKGWFERRLK 530
             EL+      +  T+ +E L              +  V+ LQ +   + G     ERR+ 
Sbjct: 787  AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVA 846

Query: 531  EAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLK 590
            + +  ++  + ++ +A K+  +++  E++  EE L   R + ++A   R      + + +
Sbjct: 847  QLQRQIEDLKGDEAKA-KETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905

Query: 591  QEVKDTVDGQRIL------EKKGSAALKDLKRQLHLER----KRADKLQERLQDILTNSK 640
              +  T   Q+ L      E +    L+ LK ++  ER    K  +KLQ+ + DI+  S+
Sbjct: 906  GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASR 965

Query: 641  SRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRP 700
            + +   +  L E    +R +  +         +  L+EK   A  +R  +   Q +    
Sbjct: 966  TSTLELQNQLDEYKEKNRRELAE--------MQRQLKEKTLEAEKSRLTAMKMQDE---- 1013

Query: 701  AELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRID 760
              L +EE+ +  +   E   ++ +LE+ +K LE                   Y ++++  
Sbjct: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE-------------------YELEAKSH 1054

Query: 761  VSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDM--EVLSQ 818
            +       DRS L   + D V   +  L E  +   ++L E+++++    + +  E+L +
Sbjct: 1055 LK-----DDRSRLVKQMEDKVSQLEMELEE-ERNNSDLLSERISRSREQMEQLRNELLQE 1108

Query: 819  EIVRLSKEC 827
               R   EC
Sbjct: 1109 RAARQDLEC 1117



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 105/509 (20%), Positives = 204/509 (40%), Gaps = 67/509 (13%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKN-GVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
            E E   ++  L E  +++ Q  D+L++    EL +LR+ V    K         + S++ 
Sbjct: 757  ERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD 816

Query: 66   Q-----EVEVLLSENEMLQAKLHSQEE---DFRLQNSTLMAEFSKLCSQMEQLEQENQQL 117
            Q      V++L  ENE LQ +    E      + Q   L  + +K    +++ E E +QL
Sbjct: 817  QAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQL 876

Query: 118  KEGAAGAG-----VAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQ 172
            +E    A         A   ++ EL   Q   +   +    L E+  +E+ +   +   +
Sbjct: 877  EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK 936

Query: 173  GDPPGG-------------PAPTVLAPMPLAEVELKWEM----EKEEKRLLWEQLQGLES 215
             +                     ++     + +EL+ ++    EK  + L   Q Q  E 
Sbjct: 937  NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK 996

Query: 216  SKQAETSRL-----QEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEA- 269
            + +AE SRL     Q+E+  + E+L+  Q +     T+++ L    ++   EL+ +    
Sbjct: 997  TLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLK 1056

Query: 270  DHKAQLAR-----TQKLQQELEAANQSL----------AELRDQRQGERLEHAAALRALQ 314
            D +++L +       +L+ ELE    +            E  +Q + E L+  AA + L+
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116

Query: 315  -DQVSI--QSADAQEQV-----------EGLLAENNALRTSLAALEQIQTAKTQELNMLR 360
             D++S+  Q+ D + ++           EGL+ +  A    L    + +      L +  
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSN 1176

Query: 361  EQTTGLAAELQQQ-QAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQEL 419
             +      EL  Q   E+  L  QKD L+ +L+   R      E++  +   K++L +EL
Sbjct: 1177 RRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQREL 1236

Query: 420  QEARKSAEKRKAMLDELAMETLQEKSQHK 448
            +E     E  +  L+ +  +   +K   K
Sbjct: 1237 EEQMDMNEHLQGQLNSMKKDLRLKKLPSK 1265


>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
          Length = 898

 Score =  120 bits (301), Expect = 5e-27
 Identities = 165/688 (23%), Positives = 309/688 (44%), Gaps = 103/688 (14%)

Query: 189 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCR---- 244
           + ++E + E   +E +   +QL   + + +    +L +E+A+  E+  KK E   +    
Sbjct: 251 IKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA 310

Query: 245 -----LQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQR 299
                ++ EKE+L  D R + E L+++    +K     T K++Q L      L +L + +
Sbjct: 311 MVMKYVRGEKESL--DLRKEKETLEKKLRDANKELEKNTNKIKQ-LSQEKGRLHQLYETK 367

Query: 300 QGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNML 359
           +GE       +  L++ ++      +     L AE ++ + +   L++  T  TQ     
Sbjct: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQA---- 423

Query: 360 REQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE-QLQEIGQEKEQLTQE 418
           +E+   +    Q     Y++    ++  +++L   LR     LE Q+QE   + E    +
Sbjct: 424 KEEADQIRKNCQDMIKTYQE---SEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK 480

Query: 419 LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
           ++E        K  +DEL   TL+ K +  E+    RLR E E+   +    R+  E+  
Sbjct: 481 IKELEDLKRTFKEGMDEL--RTLRTKVKCLED---ERLRTEDELSKYKEIINRQKAEIQN 535

Query: 479 --DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM----DGAKG------WFE 526
             DK +  ++L+ Q++  K   +E+E L++ VE L + ++ +    +G++        F 
Sbjct: 536 LLDKVKTADQLQEQLQRGK---QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFT 592

Query: 527 RRLKEAEESLQQ-----------------QQQEQEEALKQCREQHAAELKGKEEELQDVR 569
            RL      LQ                  Q Q Q E +KQ      + L  KEEEL+   
Sbjct: 593 ERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLL-KEEELRKEE 651

Query: 570 DQLEQAQEE-RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKL 628
            Q  QA+   R   +K +S+  +E+KD +  QR   +K ++++KDL +QL   R++ D++
Sbjct: 652 VQTLQAELACRQTEVKALSTQVEELKDELVTQR---RKHASSIKDLTKQLQQARRKLDQV 708

Query: 629 QERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARS 688
           +             SG  +  +S M S S + +G  ++ SS   R    E   S+V   +
Sbjct: 709 E-------------SGSYDKEVSSMGSRS-SSSGSLNARSSAEDRS--PENTGSSV---A 749

Query: 689 LSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSA 748
           + + PQ            + A L +R+   Q+      EK++ +E     + E++ +K+ 
Sbjct: 750 VDNFPQV-----------DKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTK 798

Query: 749 IIETYVM-DSRIDVSVAAGHTDRSGL---GSVLRDLVK--PGDENLR-----EMNKKLQN 797
           II++Y++ +    +S  A   ++  L   G ++  L    P D  L      E+N+KLQ 
Sbjct: 799 IIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQA 858

Query: 798 MLEEQLTKNMHLHKDMEVLSQEIVRLSK 825
           +LE+ L KN+ L ++++ L  EI RL K
Sbjct: 859 VLEDTLLKNITLKENLQTLGTEIERLIK 886



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 77/411 (18%), Positives = 162/411 (39%), Gaps = 66/411 (16%)

Query: 26  QLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQ 85
           QL ++L++   E+ +L+++V  L+   +  QK +  S+K +   +L +E      +L S+
Sbjct: 545 QLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTE------RLTSK 598

Query: 86  EEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG--AGVAQAGPLVDGELLRLQAE 143
               + ++++L ++F K+     QL+ + +Q+K+      + + +   L   E+  LQAE
Sbjct: 599 NAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAE 658

Query: 144 NTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEK 203
               Q  V AL                           T +  +    V  + +     K
Sbjct: 659 LACRQTEVKALS--------------------------TQVEELKDELVTQRRKHASSIK 692

Query: 204 RLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFN-DSRNKIEE 262
            L  +  Q      Q E+    +E++ +  +         R   E  +  N  S   ++ 
Sbjct: 693 DLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 752

Query: 263 LQQRKEADHKAQLARTQKL----QQELEAANQSLAELRDQ-RQGERLEHAAALRALQDQV 317
             Q  +A    ++ R QK      +++E     + +L ++ R+  ++  +  LR   ++ 
Sbjct: 753 FPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR---EES 809

Query: 318 SIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY 377
              S++A +  +  L+    +  SL          T EL++          E+ ++    
Sbjct: 810 GTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSL----------EINRK---- 855

Query: 378 EDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK 428
                    L + L+++L  N  L E LQ +G E E+L +   E  +  +K
Sbjct: 856 ---------LQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  120 bits (301), Expect = 5e-27
 Identities = 192/883 (21%), Positives = 383/883 (43%), Gaps = 113/883 (12%)

Query: 7    EEEFQRMQAQ-----------LLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA 55
            EEE  R++A+           +  L ++N  + +EL +  +E  +L +K   L  E    
Sbjct: 1693 EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD-- 1750

Query: 56   QKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ 115
                S S++ Q+++  +  N   QA L + E+     N T + E        E  EQ++ 
Sbjct: 1751 ----SLSEEVQDLKHQIEGNVSKQANLEATEKH---DNQTNVTEEGTQSIPGETEEQDSL 1803

Query: 116  QLKE----GAAGAGVAQAGPLVDGELLRLQAENTALQK------NVAALQERYGKEAGKF 165
             +        +      A P V  +       N  LQ+       +A L+E   K   +F
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK-EF 1862

Query: 166  SAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEK-RLLWEQLQG-----------L 213
            S   E + +       T+L+ +   + ELK   E+  K  LL +Q+Q             
Sbjct: 1863 SQTLENEKN-------TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915

Query: 214  ESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK---IEELQQRKEAD 270
            E  K     RL  +LA+L+  +    +     Q + E L ++ +N    + EL++ K+  
Sbjct: 1916 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ-- 1973

Query: 271  HKAQLARTQKLQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVSIQSADAQEQVE 329
               QL + +K + E E   + L +++  Q++     HA  L+ L  +   +    Q+   
Sbjct: 1974 ---QLVK-EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029

Query: 330  GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNS 389
                + +AL  ++ ALE +QT   ++L + +E         ++ QAE        DD  S
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089

Query: 390  QLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKE 449
            +    L  N +L ++LQ     KE +  ++++  +  E+R   L++   + L+EK   +E
Sbjct: 2090 EAARVLADNLKLKKELQ---SNKESVKSQMKQKDEDLERR---LEQAEEKHLKEKKNMQE 2143

Query: 450  ELGAVRLR--HEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 507
            +L A+R    H +E +G     +  L +  ++ ++ +E L   + +  A T+ + +LQ  
Sbjct: 2144 KLDALRREKVHLEETIG---EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200

Query: 508  VEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQD 567
             + +      +D AK W ER+  +A +S +++ + +E+     ++Q   ++    EEL+ 
Sbjct: 2201 RDRV------IDEAKKW-ERKFSDAIQSKEEEIRLKEDNCSVLKDQ-LRQMSIHMEELKI 2252

Query: 568  VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 627
               +LE  ++  +   +T   L+Q+V DT+ G+    K+  + L++ +   H  +    K
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGE---NKELLSQLEETRHLYHSSQNELAK 2309

Query: 628  LQERLQDI------LTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKES 681
            L+  L+ +      L+NS  +   ++     +    R Q  D  + S FSY ++  + ++
Sbjct: 2310 LESELKSLKDQLTDLSNSLEKCKEQK---GNLEGIIRQQEADIQN-SKFSYEQLETDLQA 2365

Query: 682  S-AVPAR--------------SLSSSPQAQPPRPAEL---SDEEVAELFQRLAETQQEKW 723
            S  + +R               LS   +A     AEL    D+E+ EL   L++ ++E  
Sbjct: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425

Query: 724  MLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKP 783
            +LEE+ K     +  + E L  K+   E     +++D  V +  + ++    ++ D  + 
Sbjct: 2426 VLEEENKKAVDKTNQLMETL--KTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483

Query: 784  GDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
             + +L  + +K Q +++E   +N  L +++  L   +  L+ E
Sbjct: 2484 EERHLSIILEKDQ-LIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 179/804 (22%), Positives = 317/804 (39%), Gaps = 113/804 (14%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQL---SDELRKNGVELTSLRQKVAYLDKEFSKAQKAL 59
            QA++EE    +Q +++EL      L   S EL +   E   L  ++  L+ +     +  
Sbjct: 463  QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ----NRTG 518

Query: 60   SKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKE 119
               ++  E+ ++   N+   +   S ++      S    E S L  +M++ ++E   LK 
Sbjct: 519  EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578

Query: 120  GAAGAGVAQAGPLV--DGELLRLQAENTALQKNVAALQER------YGKEAGKFSAVSEG 171
               G    +A   V    E+ +++ E  A  K    L++          E     AV + 
Sbjct: 579  QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638

Query: 172  QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL 231
            Q         +    +  A VELK   +  +K L    +  +    Q E  RL+ ++ +L
Sbjct: 639  QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSL--SAVPDIGQCHQDELERLKSQILEL 696

Query: 232  SEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQS 291
                 K QE + +   EK    ++    IEE   +K AD+ +             +A  +
Sbjct: 697  ELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF--KKNADNNS-------------SAFTA 741

Query: 292  LAELRDQ--RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQ 349
            L+E RDQ   Q + L     LRA   Q+ +  A+A+ Q                      
Sbjct: 742  LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-----------------RRLDY 784

Query: 350  TAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ--- 406
             ++T   N+L EQ   L+ E + +  + E L  + DD+  Q  E       L  QLQ   
Sbjct: 785  ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844

Query: 407  -EIGQEKEQL------TQELQEARKSAEKRKAMLDELAME----------TLQEKSQHKE 449
             E+ +  E++       +EL +A    E     +D+L +E          T++EK Q   
Sbjct: 845  SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904

Query: 450  ELG------AVRLRHEKEVLGVRARYERE----LRELHEDKKRQEEELRGQIREEKARTR 499
            E+        V+L  EK  LGV  +  +E    L    E KK Q EE        K    
Sbjct: 905  EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964

Query: 500  ELETLQQ-TVEELQAQVHSMDGAKGWFERRLKEA---EESLQQQQQEQEEALKQCREQHA 555
            E+    Q + EELQ +   +       +R+L+ A    + L Q+    EE L   +++  
Sbjct: 965  EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK 1024

Query: 556  AELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSA--ALKD 613
             E+   E E    R ++E+ +E ++   K ++S  QE++  +  Q I EK+       KD
Sbjct: 1025 KEIPLSETE----RGEVEEDKENKEYSEKCVTSKCQEIEIYLK-QTISEKEVELQHIRKD 1079

Query: 614  LKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNS------PSRTQTGDSSSI 667
            L+ +L  E ++   L +++   L +  ++  L +  +SE  +       S T   D  S+
Sbjct: 1080 LEEKLAAE-EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138

Query: 668  SSFSYREILREKESSAVPARSLSSSPQAQPPRPAEL--SDEEVAELFQRLAETQQEKWML 725
            +          KE+  +      SS   +P    ++   ++E  +L ++L E    +  +
Sbjct: 1139 ALV--------KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI 1190

Query: 726  ----EEKVKHLEVSSASMAEDLCR 745
                +EK +HL        +D  R
Sbjct: 1191 LKKAQEKERHLREELKQQKDDYNR 1214



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 162/879 (18%), Positives = 359/879 (40%), Gaps = 85/879 (9%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELT-SLRQKVAYLDKEFSKA-----QKALS 60
            ++++ R+Q Q  E    N  + D+LR+  +++  S+  K+   D++ S +     ++ L 
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
            K+ +    + +L  N       HS++    LQ  T +A+     +Q++++E E  +L+  
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDAS-ALQGGTSVAQIK---AQLKEIEAEKVELELK 1324

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVS-EGQGDPPGGP 179
             +             EL +   E   LQ+ +     + G E      VS E +       
Sbjct: 1325 VSST---------TSELTKKSEEVFQLQEQI----NKQGLEIESLKTVSHEAEVHAESLQ 1371

Query: 180  APTVLAPMPLAEVELKWEMEK---EEKRLLWEQ------LQGLESSKQAETSRLQEELAK 230
                 + + +A +E   E++    E ++L+ ++      L G  S K+A  +++Q E+ +
Sbjct: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431

Query: 231  LS------------------EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEA--- 269
                                E++K+ Q   C ++ + E +  +SR K +++Q++ +A   
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK-QQIQRKLQAALI 1490

Query: 270  DHKAQLARTQKLQQELEAAN-------QSLAELRDQRQGERLEHAAALRALQDQVSIQSA 322
              K  L   + LQ+EL  A        +SLA++  Q   +  E    L  L      +  
Sbjct: 1491 SRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDK 1550

Query: 323  DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMG 382
               E    LL EN +L +S  +L+      T++   L ++   L +    +  E+++   
Sbjct: 1551 LITEMDRSLL-ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHK 1609

Query: 383  QKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
            +       L +S    S   E++Q + +   Q  QEL    +S E  K   ++   E  Q
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669

Query: 443  EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELE 502
            E  + KE++       ++++L +    +R   E+H      +E +   +    +   ELE
Sbjct: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729

Query: 503  TLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKE 562
             ++   E L  +  S+   K      +++ +  ++    +Q  A  +  E+H  +    E
Sbjct: 1730 RVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ--ANLEATEKHDNQTNVTE 1787

Query: 563  EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSA--ALKDLKRQLHL 620
            E  Q +  + E   E+    + T  +  + V         + K  S+   + +  +Q+  
Sbjct: 1788 EGTQSIPGETE---EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844

Query: 621  ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKE 680
             ++R   L+E  Q     S++    +  +LS++++           ++  +      ++E
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEE 1904

Query: 681  SSAVPARSLSSSPQAQPPRPAELSDEEVAEL-------FQRLAETQQEKWMLEEKVKHLE 733
             S V    L  + + +     E    ++AEL        Q + + Q +  +LE ++K+L+
Sbjct: 1905 LSRV--TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK 1962

Query: 734  VSSASMAED---LCRKSAIIETYVMDSRID-VSVAAGHTDRSGLGSVLRDLVKPGDENLR 789
               + + E+   L ++   +E+ +    ++ +  A            L++L+K   + ++
Sbjct: 1963 KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022

Query: 790  EMNKKLQNMLEE--QLTKNMHLHKDMEVLSQEIVRLSKE 826
            ++ K      E+   L + +   + ++  SQ+ + ++KE
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 177/872 (20%), Positives = 364/872 (41%), Gaps = 119/872 (13%)

Query: 2    AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
            A  +S+EE Q    +   L+  N Q   +L+   +    L Q+V+ L++E +  +    +
Sbjct: 969  AGQISKEELQH---EFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK---DE 1022

Query: 62   SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAE-----FSKLCSQME-QLEQENQ 115
            SKK    E+ LSE E  + +   + +++  +  T   +       +  S+ E +L+   +
Sbjct: 1023 SKK----EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK 1078

Query: 116  QLKEGAAG-----AGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSE 170
             L+E  A      A V Q    +  +  ++      + +N A +Q+         S    
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLIT------SNTDA 1132

Query: 171  GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL--------LWEQLQGLESSKQAETS 222
              GD       TV+   P       W+ E EEK L        L ++LQ   +S++A   
Sbjct: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192

Query: 223  RLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQ-----RKEADHKAQLAR 277
            + QE+   L E+LK++++ + RLQ + +    ++ N  ++L+Q     R+  D K     
Sbjct: 1193 KAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252

Query: 278  TQKLQQELEAANQSLAELRDQRQGERL----------EHAAALRALQDQVSIQSADAQEQ 327
             Q+         + L +  +Q   + +           H+    ALQ   S+  A  + Q
Sbjct: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSV--AQIKAQ 1310

Query: 328  VEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDL 387
            ++ + AE   L   +++     T K++E+  L+EQ      E++  +    +     + L
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370

Query: 388  NSQLQESLRANSRLLEQLQEIGQEK-EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQ 446
              +L+ S         QLQ  G E   +L  +L E +K   K++  +  L+ + L EK  
Sbjct: 1371 QQKLESS---------QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ-LSEKEA 1420

Query: 447  HKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQ 506
               ++    +  E  +  +  + E + +E H+++ +Q   L+ ++ E K +  E+    +
Sbjct: 1421 ALTKIQTEIIEQEDLIKALHTQLEMQAKE-HDERIKQ---LQVELCEMKQKPEEIGEESR 1476

Query: 507  TVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQ 566
              +++Q ++          +  L   +E+L++ +  QEE L   R      ++   + L 
Sbjct: 1477 AKQQIQRKL----------QAALISRKEALKENKSLQEE-LSLAR----GTIERLTKSLA 1521

Query: 567  DVRDQLEQAQEERDCHLKTISSLKQEVKDTVD--GQRILEKKG-SAALKDLKRQLHLERK 623
            DV  Q+    +E+D  L  ++ L++E    +    + +LE +  S++ + LK  L LE  
Sbjct: 1522 DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK--LALEGL 1579

Query: 624  RADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSA 683
              DK                   E ++ E+ S   ++  +S+      ++E+ +E E   
Sbjct: 1580 TEDK-------------------EKLVKEIESLKSSKIAESTEWQE-KHKELQKEYEILL 1619

Query: 684  VPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDL 743
                ++S+  + +     E   +E  EL+ +L  T+  K   E++++  E     M E +
Sbjct: 1620 QSYENVSNEAE-RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1678

Query: 744  -----CRKSAIIETYVMDSRIDVSV-AAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQN 797
                  ++  I+E    + R+   V  AG T +  + ++L       + +++E  ++++ 
Sbjct: 1679 RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL-----SSNASMKEELERVKM 1733

Query: 798  MLEEQLTKNMHLHKDMEVLSQEIVRLSKECVG 829
              E    K   L  + + LS+E+  L  +  G
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG 1765



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 197/925 (21%), Positives = 358/925 (38%), Gaps = 145/925 (15%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
            L E E + ++  + EL     QL  E  K   E+     +  YL+K    AQK       
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI-----RKEYLEK-IQGAQKEPGNKSH 2006

Query: 65   AQEVEVLLSENEMLQAKLHS-----QEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKE 119
            A+E++ LL E +    +L       QE+   L+ +    EF +  SQ + LE   + L +
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD-LEITKENLAQ 2065

Query: 120  GA-----AGAGVAQAGPLVD---GELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEG 171
                   A A +A    L+D    E  R+ A+N  L+K + +      KE+ K     + 
Sbjct: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS-----NKESVKSQMKQKD 2120

Query: 172  QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWE---QLQGLESSKQAETSRLQEEL 228
            +                   ++ K +  + EK  L E   ++Q   + K  E  +LQE L
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRN---KIEELQQRKEADHKAQLARTQKLQQEL 285
                 +L    +S   LQ +++ + ++++    K  +  Q KE + + +      L+ +L
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240

Query: 286  EAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAAL 345
               +  + EL+      RLEH   +   + Q  +Q    Q+  + L  EN  L + L   
Sbjct: 2241 RQMSIHMEELKINIS--RLEHDKQIWESKAQTEVQLQ--QKVCDTLQGENKELLSQLEET 2296

Query: 346  EQI------QTAKTQ-ELNMLREQTTGLAAELQ--------------QQQAEYEDLMGQK 384
              +      + AK + EL  L++Q T L+  L+              QQ+A+ ++     
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356

Query: 385  DDLNSQLQESLRANSRLLEQLQ----------------------EIGQEKEQLTQELQEA 422
            + L + LQ S    SRL E++                       E+ Q+ ++  +EL+  
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENL 2416

Query: 423  RKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRAR---YERELRELHED 479
                E+   +L+E   + + + +Q  E L  ++    KE +  +A+   + + +  L  D
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIK----KENIQQKAQLDSFVKSMSSLQND 2472

Query: 480  KKR------QEEELRGQIREEKAR-----TRELETLQQTVEELQAQVHSMDGAKGWFERR 528
            + R      Q EE    I  EK +       E   L++ +  L++ +  ++      +  
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532

Query: 529  LKEAEESL--------QQQQQEQEEALKQCRE------QHAAELKGKEEELQDVRDQLEQ 574
            L +  E L         QQ+Q  E  L+Q +E      +   +LK  EE  +D+R     
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592

Query: 575  AQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQD 634
             QEE+    K I SLK  +         L+++G+  L       H + K  ++   RL  
Sbjct: 2593 LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL------YHAQLKVKEEEVHRLSA 2646

Query: 635  ILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQ 694
            + ++S+ R    E  L  +   +  + G+         ++ L+     A   R+      
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIED----KLKKELKHLHHDAGIMRN------ 2696

Query: 695  AQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDL-----CRKSAI 749
                   E ++E VAEL + L E +Q+  M+ ++ K L     S    +      R  A 
Sbjct: 2697 -----ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751

Query: 750  IETYVMDSRIDVSV---------AAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLE 800
             E   +  + D S+            + +R  L S     +   +EN     +KL   L 
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811

Query: 801  EQLTKNMHLHKDMEVLSQEIVRLSK 825
             +  + +HL   +E    ++   SK
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSK 2836



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 186/901 (20%), Positives = 365/901 (40%), Gaps = 137/901 (15%)

Query: 49   DKEFSKAQKALSKSK-KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQM 107
            DK  ++ +  + K K K QE E L+S    LQA+L   + +   Q+ST M EF  +  Q+
Sbjct: 136  DKSSTEEEMEIEKIKHKLQEKEELIST---LQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192

Query: 108  EQLEQENQQLKEGAAGAGVAQAGPLV---------------DGELLRLQAE---NTALQK 149
            ++ E+    L+   +     QA   V               + ELL+L  +    T +Q+
Sbjct: 193  QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252

Query: 150  NVAALQERYGKE----AGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKW-------EM 198
             +  LQ +  +      G+   V   Q +         +    L ++E +        E 
Sbjct: 253  KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312

Query: 199  EKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRN 258
            E+EE ++L E+++   + ++     LQEE+  L E+ ++  ++   L++    L    + 
Sbjct: 313  EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372

Query: 259  KIEELQQRKEADHKAQLART-QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQV 317
            ++EE     +  H   L +T Q+LQ   +A     ++L   +  + ++ A  ++ L+DQ+
Sbjct: 373  EMEE-----KTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQL 427

Query: 318  SIQSADAQEQVEGLLAENN--ALRTSLAAL--EQIQTAKTQELNMLREQTTGLAAE---L 370
              +S +  + +  L  + +  A +TS   +  E  Q    + +  L+++   L  E   L
Sbjct: 428  QQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGAL 487

Query: 371  QQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ------------EKEQLTQE 418
                 E E+L  + + L+SQ+   L A +R  E  +E+ +              E+  Q+
Sbjct: 488  LLSSIELEELKAENEKLSSQI-TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQD 546

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQH-KEELGAVRLRH-EKEVLGVRARYERE---- 472
            + E   S + ++  +  L M+  QE+    K +L   R    + EVL  +   + E    
Sbjct: 547  VLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606

Query: 473  ----LRELHEDKKR------QEEELRGQIREEKARTRELETLQQTVEELQAQVH----SM 518
                ++   ED  +       EE     + +E+A T       + +    A V       
Sbjct: 607  APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 666

Query: 519  DGAKGW-----FERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLE 573
            DG K         +  ++  E L+ Q  E E    + +E +   L  K +E+ ++   +E
Sbjct: 667  DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIE 726

Query: 574  Q--------------AQEERD------CHLKTISSLKQEVKD------TVDGQRILEKKG 607
            +                EERD        L  ++ L+ +VK         + QR L+ + 
Sbjct: 727  EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYES 786

Query: 608  SAALKD-LKRQLH---LERKRAD----KLQERLQDILTNSKSRSGLEELVLSEM-NSPSR 658
              A  + L  Q+H   +E K  D     LQ  L D+      +S L   + S++ N  S 
Sbjct: 787  QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846

Query: 659  TQTGD------SSSISSFSYREILREKESSAVPARSLSSSPQAQP-PRPAELSDEEVAE- 710
               G       SS +   S     +E E + +    L      +   +  E  D++V E 
Sbjct: 847  VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI 906

Query: 711  ---LFQRLAETQQEKWMLEEKVKHL--EVSSASMAEDLCRKSAIIETYVMDSRIDVSVAA 765
               + +++ +  +EK+ L  ++K L  +++  S AE+  +K  + E    D+ +   +  
Sbjct: 907  SFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE-AKKEQVEE----DNEVSSGLKQ 961

Query: 766  GHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSK 825
             + + S  G + ++ ++   + L++ N++ +  L+  L     L + +  L +E+  L  
Sbjct: 962  NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021

Query: 826  E 826
            E
Sbjct: 1022 E 1022



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 144/693 (20%), Positives = 272/693 (39%), Gaps = 97/693 (13%)

Query: 19   ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK------SKKAQEVEVLL 72
            E    N +L +E+R     +  L  + A LD E  + ++ L++      S++ Q +EV L
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2559

Query: 73   SENEMLQ---AKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLK----------- 118
             +N+ L+   AKL  + ++    N  L   F+ L  + + L +E + LK           
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619

Query: 119  ----EGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERY---GKEAGKFSAVSEG 171
                EG  G   AQ   + + E+ RL A  ++ QK +A L+E      KEA K     E 
Sbjct: 2620 ALQEEGTLGLYHAQL-KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678

Query: 172  Q----------------GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLE- 214
            +                 +              L E+E K  M  +E + L  Q+Q    
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGR 2738

Query: 215  --SSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKI-EELQQRKEADH 271
              SS Q       EEL +L  K     +   +L+  ++ L N  R+ +  E      +  
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKYDASLKELAQLK--EQGLLNRERDALLSETAFSMNSTE 2796

Query: 272  KAQLARTQKLQQELEAANQSLAELRDQ-----RQGERLEHA-AALRALQDQVSIQSADAQ 325
            +  L+  +KL Q+L + ++ L  L  Q      Q +    A A+L+  +D +  +    +
Sbjct: 2797 ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR 2856

Query: 326  EQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 385
            +  EG         TS A ++ ++ A +   N  R++       LQQQ  +    + +  
Sbjct: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND-RDRLLKELKNLQQQYLQINQEITELH 2915

Query: 386  DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEAR---KSAEKRKAMLDELAMETLQ 442
             L +QLQE            +E+ QE      EL + R    S E  +  + E  +  + 
Sbjct: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975

Query: 443  EKSQ---HKEELGAVRLRHEKEVLGVRARYERELR-------ELHEDKKRQEEELRGQIR 492
            +K Q   H + L         +   ++ +Y+R+         +  ++   + E LR Q+ 
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035

Query: 493  EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQC-- 550
            +     +E+   +  +++L +    +   K     +L +  +SL++ QQ   + L  C  
Sbjct: 3036 DS---LKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAV 3092

Query: 551  ----------------------REQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISS 588
                                  +E++    K   EEL++ +    +AQ++     + ++ 
Sbjct: 3093 LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNE 3152

Query: 589  LKQEVKDTVDGQRILEKKGSAALKDLKRQLHLE 621
            L++ +++  D +   E   S A + ++R  H E
Sbjct: 3153 LRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 132/599 (22%), Positives = 242/599 (40%), Gaps = 101/599 (16%)

Query: 267 KEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQE 326
           +E+D +      + +Q+ L  A Q + EL+D  +             Q  V +Q  D   
Sbjct: 36  QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIR-------------QKDVQLQQKDEAL 82

Query: 327 QVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDD 386
           Q E   A+N   +  L A      AK   LN   E+       +   + + E+ + + D 
Sbjct: 83  QEERKAADNKIKKLKLHA-----KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHD- 136

Query: 387 LNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ------EARKSAEKRKAMLDELAM-E 439
             S  +E +      +E+++   QEKE+L   LQ      +A + A+    M + + M +
Sbjct: 137 -KSSTEEEME-----IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 440 TLQEK-----------SQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELR 488
            LQEK           SQ + E  A ++  EK+     AR+E ++R LHED+  Q   L 
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD-----ARFETQVR-LHEDELLQ---LV 241

Query: 489 GQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALK 548
            Q   E    ++L  LQ+ +EE +  +          ++ L  AE    Q+ Q   + L+
Sbjct: 242 TQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE----QRNQILSQQLQ 297

Query: 549 QCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGS 608
           Q   +H       E E ++ +  LE+ + E      +  +L++E+   ++     E+ G 
Sbjct: 298 QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ---FEQAGQ 354

Query: 609 AALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEEL--VLSEMNSPSRTQTGD--- 663
           A  +   R   LE+K   +++E+   IL+  K+   L+     L + NS       +   
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414

Query: 664 ----------------SSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEE 707
                           S  IS F  R  L++ E++     S +S P         +++E 
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA-----SQTSFPDVYNEGTQAVTEEN 469

Query: 708 VAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGH 767
           +A L +R+ E + EK  L        + S+   E+L  ++  + + +  + ++     G 
Sbjct: 470 IASLQKRVVELENEKGAL--------LLSSIELEELKAENEKLSSQI--TLLEAQNRTGE 519

Query: 768 TDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
            DR      + D+      +  E     Q++LE   ++    HK++ VL  E+    +E
Sbjct: 520 ADREVSEISIVDIANKRSSSAEESG---QDVLENTFSQK---HKELSVLLLEMKEAQEE 572



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 92/394 (23%), Positives = 168/394 (42%), Gaps = 40/394 (10%)

Query: 357 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLN------SQLQESLRANSRLLEQLQEIGQ 410
           N++  + +G     Q  +A  +  + Q+ D+         +QE L    +L+ +L++I +
Sbjct: 10  NVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIR 69

Query: 411 EKE----QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVR 466
           +K+    Q  + LQE RK+A+ +   L   A   L   +++ EE+ A        VL   
Sbjct: 70  QKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKA----QGGTVLPTE 125

Query: 467 ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFE 526
            + E +L +   DK   EEE+  +I + K + +E E L  T++    Q  +   A+    
Sbjct: 126 PQSEEQLSK--HDKSSTEEEM--EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQS--- 178

Query: 527 RRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTI 586
               E EE +  +QQ QE      +E+  + L+ +  + Q      +Q   E+D   +T 
Sbjct: 179 --STEMEEFVMMKQQLQE------KEEFISTLQAQLSQTQ-AEQAAQQVVREKDARFETQ 229

Query: 587 SSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKR---ADKLQERLQDILTNSKSRS 643
             L ++    +  Q  +E +    L+ L+R+L    +      ++ + LQ  LT ++ R+
Sbjct: 230 VRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN 289

Query: 644 GLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLS----SSPQAQPPR 699
            +    L +M +   T      +    S  +IL EK    V  R LS             
Sbjct: 290 QILSQQLQQMEAEHNTLRNTVETEREES--KILLEKMELEVAERKLSFHNLQEEMHHLLE 347

Query: 700 PAELSDEEVAELFQRLAETQQE-KWMLEEKVKHL 732
             E + +  AEL  R +  +Q+ K  +EEK  H+
Sbjct: 348 QFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  120 bits (300), Expect = 7e-27
 Identities = 186/890 (20%), Positives = 374/890 (42%), Gaps = 125/890 (14%)

Query: 4    ALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQK--------------VAYLD 49
            A+  +E Q++++ + EL   N  L++ L K   + T L +K              +   D
Sbjct: 284  AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343

Query: 50   KEFSKAQKALSKSKKA-QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQME 108
             +  + Q  LS S+ +   + V LSE      KL  +  +   +   L AEF +L  Q E
Sbjct: 344  LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403

Query: 109  QLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAV 168
            + EQ   QL+                 E+ +L ++   L +    L E +G+   +    
Sbjct: 404  EKEQHGLQLQS----------------EINQLHSK---LLETERQLGEAHGRLKEQRQLS 444

Query: 169  SEGQGDPPGGPAPTVLAPMPLAE---------VELKWEMEKEEKRLLWEQLQGLESSKQA 219
            SE   D     A   L    L E          EL+ +++K +++   ++ Q L+ S  A
Sbjct: 445  SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ--HQEQQALQQSTTA 502

Query: 220  ETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADH------KA 273
            +    Q +L ++  ++  K +    L    E L   S+  I  L++ +E  +      + 
Sbjct: 503  KLREAQNDLEQVLRQIGDKDQKIQNL----EALLQKSKENISLLEKEREDLYAKIQAGEG 558

Query: 274  QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD---AQEQVEG 330
            + A   +LQ++     + + +L ++ + +   H  A   L DQV  Q A    AQ++V  
Sbjct: 559  ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618

Query: 331  LLAENNALRTSLAALEQIQTAKTQELNM-LREQTTGLAAELQQQQAEYEDLMGQKDDLNS 389
            L    N L + L   ++    K  +L++ ++ +T  L +    + A+  DL    D   +
Sbjct: 619  LETSVNELNSQLNESKE----KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674

Query: 390  QLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKE 449
             LQ+         ++L +I  + +Q+T +LQ+ ++   + ++ L E   + L  + + +E
Sbjct: 675  ALQDK-------QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727

Query: 450  ELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEE-ELRGQIREEKARTRELETLQQTV 508
              G ++ + E + L V+A  E+ L++L + ++   + ELR      K    E E +  T 
Sbjct: 728  LEGQIK-KLEADSLEVKASKEQALQDLQQQRQLNTDLELRA-TELSKQLEMEKEIVSSTR 785

Query: 509  EELQAQVHSMDGAKGWFERRLKEAEESLQQ---QQQEQEEALKQCREQHAAELKGKEEEL 565
             +LQ               +  EA ES++Q   +Q+E+++ LKQ  E  + E K + EEL
Sbjct: 786  LDLQ---------------KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830

Query: 566  ----QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE-------KKGSAAL--- 611
                Q    +L++ + E++  +  +S++K ++    D  +  +       +KG AA+   
Sbjct: 831  NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890

Query: 612  ----KDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSP------SRTQT 661
                K+LK QL ++ +   K Q+ L+  L   K  S   +L L+ M         +  Q 
Sbjct: 891  EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN 950

Query: 662  GDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSD---EEVAELFQRLAET 718
                     +  E+ +  E       +L    +    +  EL +   +++ +  Q LA  
Sbjct: 951  EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010

Query: 719  QQEKWMLEEKVKHLEVSSASMAEDLC-RKSAIIETYVMDSRIDVSVAAGHTD----RSGL 773
            +++  +L+   +  + +   +  D   R+S ++ T      ++  ++    D    R+ +
Sbjct: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI 1070

Query: 774  G--SVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIV 821
            G  + L   +K     L + + K +  L+E+      + K+  +  +E+V
Sbjct: 1071 GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV 1120



 Score =  110 bits (275), Expect = 5e-24
 Identities = 142/662 (21%), Positives = 282/662 (42%), Gaps = 77/662 (11%)

Query: 2    AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
            AQ    ++ Q  +A L   +     L   + +   +L   ++KV+ LD +     + L  
Sbjct: 594  AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653

Query: 62   SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAE--FSKLCSQMEQLEQENQQLKE 119
            ++ A+  +    +N +  A+   Q++   L   T   +   +KL  + E   Q    LKE
Sbjct: 654  AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713

Query: 120  GAAG-AGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGG 178
                   + Q    ++G++ +L+A++         L+ +  KE        + Q      
Sbjct: 714  YKEKYLSLEQKTEELEGQIKKLEADS---------LEVKASKEQALQDLQQQRQ------ 758

Query: 179  PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKK 238
                +   + L   EL  ++E E++         + SS + +  +  E L  + +KL K+
Sbjct: 759  ----LNTDLELRATELSKQLEMEKE---------IVSSTRLDLQKKSEALESIKQKLTKQ 805

Query: 239  QESFCRLQTEKETLFNDSRNKIEELQ----------QRKEADHKAQLARTQKLQQELEAA 288
            +E    L+ + ETL  +++ + EEL           Q+ + + +A +     ++ +L   
Sbjct: 806  EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865

Query: 289  NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQI 348
            + SL   + + + E  +  AA+  L+          Q Q+E  L E   L+ SL   ++ 
Sbjct: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925

Query: 349  QTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI 408
                  ELN ++EQ       L+Q + E + L G  ++L    ++  +    L  +L+  
Sbjct: 926  SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985

Query: 409  GQEKEQLTQELQEARKSAEKRKAMLDE--LAMETLQEKSQHK-EELGAVRLRHEKEVLGV 465
              +K +L  +LQ+    A +  A   E    ++   EKSQ   ++L +     E E+L  
Sbjct: 986  VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045

Query: 466  RARYERELRELHEDKKRQEEEL---RGQIREEKARTRELETLQQTVEELQAQVHSMDGAK 522
            R    ++L+ + E     +E+L   R QI  +    +EL+T + T+E+        D AK
Sbjct: 1046 R----QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ--------DSAK 1093

Query: 523  GWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVR----DQLEQAQEE 578
               E++L+E  ++LQ  Q+E     K  +E+     K K  E+++++     ++ +  EE
Sbjct: 1094 K--EQQLQERCKALQDIQKE-----KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146

Query: 579  RDCH----LKTISSLKQEVKDTVDGQRILEKKG---SAALKDLKRQLHLERKRADKLQER 631
               H    +K I++LK   +  +  +  L+ K     AA++  KR   + + +  K +E 
Sbjct: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206

Query: 632  LQ 633
            L+
Sbjct: 1207 LK 1208



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 139/677 (20%), Positives = 295/677 (43%), Gaps = 66/677 (9%)

Query: 198 MEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEK---ETLFN 254
           +++++  LL +++Q L++S       L+EE    SE+LKK+ E +  LQ ++   + L  
Sbjct: 80  LKRDDVTLLRQEVQDLQAS-------LKEE-KWYSEELKKELEKYQGLQQQEAKPDGLVT 131

Query: 255 DSRNKIEELQQRKEADHKAQLARTQK---LQQELEAANQSLAELRDQRQGERLEHAAA-- 309
           DS  +++ L+Q+ E          Q     +Q+       +A+++ +   ER    AA  
Sbjct: 132 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191

Query: 310 -LRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLRE---QTTG 365
            +  L ++++ ++   Q+    LL        ++   E +Q     + NM  E   ++  
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERESEK 250

Query: 366 LAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKS 425
           L  E ++ Q++Y         L S+L +  +  +  +++LQ++     +LTQ+ Q   ++
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310

Query: 426 AEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELH------ED 479
             K++    +L  E   E+S  K+ + A   + + +   +++R       LH       +
Sbjct: 311 LLKKEQDYTKLE-EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369

Query: 480 KKRQEEELRGQIREEKARTR----ELETLQQTVEE-------LQAQVHSMDGAKGWFERR 528
           K    ++L+ ++ E + + +    E + LQQ  EE       LQ++++ +       ER+
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429

Query: 529 LKEAEESLQQQQQEQEEALKQCREQHAAELKGK----EEELQ-------DVRDQL----E 573
           L EA   L++Q+Q   E L   +EQ  A+L+ K    EE+L+       +++ QL    +
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMD-KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488

Query: 574 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
           Q QE++     T + L++   D     R +  K    +++L+  L   ++    L++  +
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK-DQKIQNLEALLQKSKENISLLEKERE 547

Query: 634 DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
           D+    ++  G E  VL+++   + T     + ++     ++  + ES      +L    
Sbjct: 548 DLYAKIQAGEG-ETAVLNQLQEKNHTLQEQVTQLT----EKLKNQSESHKQAQENLHDQV 602

Query: 694 QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSA--IIE 751
           Q Q       + + V  L   + E   +    +EKV  L++   +  E L    A    +
Sbjct: 603 QEQKAH-LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661

Query: 752 TYVMDSRIDVSVAAGHTDRSGLGSVLR--DLVKPGDENLREMNKKLQNMLEEQLTKNMHL 809
              + + +D +  A    +  L  +    D V    ++ +E   +L++ L+E   K + L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721

Query: 810 HKDMEVLSQEIVRLSKE 826
            +  E L  +I +L  +
Sbjct: 722 EQKTEELEGQIKKLEAD 738



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 109/492 (22%), Positives = 212/492 (43%), Gaps = 70/492 (14%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            E+E Q+ +A +L+L     +L  +L+   +E T   QK         + +K+L K K+A 
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQ-MENTLKEQK---------ELKKSLEKEKEA- 925

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMA---EFSKLCSQMEQLEQENQQLK----- 118
                    +  L+ +L+S +E      +TL     E  +L   + +L+Q ++Q K     
Sbjct: 926  --------SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977

Query: 119  -EGAAGAGVAQAGPL---VDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGD 174
             +G     V Q   L   +  +L +   E  A ++ ++ LQ  Y K    F  +   Q D
Sbjct: 978  LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL---QSD 1034

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEE----KRLLWEQLQGLESSKQAETSRLQEELAK 230
              G  +  +     L  VE K  + +E+    +  +  Q + ++  K A+ + L+++ AK
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT-LEQDSAK 1093

Query: 231  LSEKLKKKQESFCRLQTEK----ETLFNDSRN--KIEELQ--QRKEADHKAQLARTQKLQ 282
              ++L+++ ++   +Q EK    + L N+     +IEE++  Q KE     +  ++ KL+
Sbjct: 1094 KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE 1153

Query: 283  Q-----ELEAANQSLAELRDQRQGERLEHAAAL-------RALQDQVSIQSADAQ----E 326
                   L+ A Q L + + + QG+     AA+       + L+DQV  +  + +    E
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE 1213

Query: 327  QVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQA-------EYED 379
            +   L +E       +   E+ +   T ++  L E    +  E Q  Q        + +D
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD 1273

Query: 380  LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 439
            L G+   L + +Q +      LLE+  +   E E+L  ++ E ++  +   A + EL  E
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333

Query: 440  TLQEKSQHKEEL 451
                + +H + L
Sbjct: 1334 NQSLQIKHTQAL 1345



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 63/284 (22%), Positives = 112/284 (39%), Gaps = 20/284 (7%)

Query: 19   ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KAQEVEVLLSENEM 77
            EL+T    L  +  K   +L    + +  + KE S  +K L   K K  E+E +    E 
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138

Query: 78   LQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGEL 137
               KL+ + +  +L++   + E + L    + L Q+  +L+  A     A     V+ E 
Sbjct: 1139 EITKLNEELKSHKLES---IKEITNLKDAKQLLIQQKLELQGKADSLKAA-----VEQEK 1190

Query: 138  LRLQAENTALQKNVAALQERY-GKEAGKFSAVSE---GQGDPPGGPAPTVLAPMPLAE-- 191
               Q     ++K    L++ +  KEA   S + E   G        A   +    L E  
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250

Query: 192  --VELKWEMEKEEKRLLWEQ---LQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQ 246
              V+ +W+  +     L +Q   L+G  +  +A     Q+E   L E+  K +    +LQ
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310

Query: 247  TEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ 290
            T+   L     N    +Q+    +   Q+  TQ L ++    N+
Sbjct: 1311 TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNE 1354


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  118 bits (296), Expect = 2e-26
 Identities = 195/878 (22%), Positives = 384/878 (43%), Gaps = 126/878 (14%)

Query: 1    MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGV--ELTSLRQKVAYLDKEFSKAQKA 58
            +AQ+ S EE  R+Q  L +      +LS   + N +  +   L+ ++  L+KE S     
Sbjct: 378  LAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKS----- 432

Query: 59   LSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLK 118
                       +L  E E LQ  L     ++ +  ST   + S L S++  L + N + K
Sbjct: 433  -----------LLSQEKEELQMSLLKLNNEYEVIKSTATRDIS-LDSELHDL-RLNLEAK 479

Query: 119  EGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGG 178
            E      +++   L+  E+  L  +N    K++  ++++  K+  +  ++          
Sbjct: 480  EQELNQSISEKETLI-AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND 538

Query: 179  PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQ--LQGLESSKQAETSRLQEELAKLSEKLK 236
                V   +   ++++  E++ ++++L+  +  L  L  +KQ    +L++++  L ++L 
Sbjct: 539  EKKRV-HQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQ----KLEDKVENLVDQLN 593

Query: 237  KKQESFCRLQTEKETLFNDSRNKIE-------ELQQRKEADHKAQLARTQKLQQELEAAN 289
            K QES   +Q E   L    R   E       EL Q    D  +    T   ++E E  N
Sbjct: 594  KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653

Query: 290  --QSLAELRDQRQGERLEHAA-ALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 346
              Q+L+EL  ++  E L+  A  ++   +++ +   D + Q+E  LA NN L  SL    
Sbjct: 654  LKQNLSEL--EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL--SLEKNT 709

Query: 347  QIQTAKTQELNMLRE---QTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ----ESLRANS 399
             ++T K ++  +  E       L  E  + +   E+L   ++   S LQ      ++ N 
Sbjct: 710  IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQ 769

Query: 400  RLLEQLQEIGQEKEQLTQELQEAR----KSAEKRKAMLD-----ELAMETLQEKSQH-KE 449
            +   ++ E+ +  EQ+  + +E +     S E++K +       E+ +E L+E+S   +E
Sbjct: 770  KKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQE 829

Query: 450  ELG--AVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL---ETL 504
            EL   +  LR  + +       +R L  + E+    +EEL  ++REE++RT  +   +TL
Sbjct: 830  ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE-RLREEQSRTAPVADPKTL 888

Query: 505  QQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEE 564
              +V EL ++V  ++  K   E  +K  ++ ++ Q Q + + L+  +EQ        ++E
Sbjct: 889  -DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ--------KKE 939

Query: 565  LQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKR 624
            + + R Q EQ       H +      +E+K        L+K     ++ +K QLH ER  
Sbjct: 940  MDEFRYQHEQMNA---THTQLFLEKDEEIKS-------LQK----TIEQIKTQLHEER-- 983

Query: 625  ADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAV 684
                    QDI T++      +E  +  +N  + ++  D S   +    + ++E+E   +
Sbjct: 984  --------QDIQTDNSDI--FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE---L 1030

Query: 685  PARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC 744
              + L+    +   +  +LS +EV +L Q + +       LE +  H  +SS S  +D+ 
Sbjct: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKD-----LEIQALHARISSTSHTQDVV 1085

Query: 745  RKSAIIETYVMDSRIDVSVAAGHT-DRSGLGS---VLRDLVKPGDE---NLREMNKKL-- 795
                 ++ Y M+     +V    T + S L +    + D+V   +     L++ NKKL  
Sbjct: 1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLST 1145

Query: 796  ------QNMLEEQLTKNMHLHKDMEVLSQEIVRLSKEC 827
                  Q+M  E +     + ++ ++   EI  LS++C
Sbjct: 1146 RFESSGQDMFRETIQNLSRIIREKDI---EIDALSQKC 1180



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 179/908 (19%), Positives = 363/908 (39%), Gaps = 145/908 (15%)

Query: 11  QRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEV 70
           ++ +A  ++++  +    ++L++  VE++ L+ +   L  +  K Q A         V  
Sbjct: 80  EKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPA 139

Query: 71  LLSENEMLQ------AKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGA 124
             + +          +  H  + DF    S+   E ++L +++ +LE E    +  A  +
Sbjct: 140 TTASSSFAYGISHHPSAFHDDDMDFGDIISS-QQEINRLSNEVSRLESEVGHWRHIAQTS 198

Query: 125 GVAQAGPLVDGELLRLQ----------------------AENTALQKNVAALQERYGKEA 162
                      E+ +LQ                          A Q+ +  +  R+ +E 
Sbjct: 199 KAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREEL 258

Query: 163 GKFSAVSEGQGD--PPGGPAPTVLAPMPLAEVELK--WEMEKEEKRLLWEQLQGLESSKQ 218
             +    E   +    GG          + E +L   +EM+K  + L   Q++ +ES+K+
Sbjct: 259 SDYEERIEELENLLQQGGSG--------VIETDLSKIYEMQKTIQVL---QIEKVESTKK 307

Query: 219 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 278
            E  +L++++  +++KL   +     L+ E+E L  + R  +EE +  K    K Q +  
Sbjct: 308 ME--QLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAV 365

Query: 279 Q----------------------KLQQELEAANQSLAELRDQRQG-----ERLEHAAALR 311
           +                      +LQQ L  A   +  L    Q      + L+    + 
Sbjct: 366 KQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIE 425

Query: 312 ALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQ 371
            L+ + S+ S + +E    LL  NN      +   +   +   EL+ LR        EL 
Sbjct: 426 VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATR-DISLDSELHDLRLNLEAKEQELN 484

Query: 372 QQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKA 431
           Q  +E E L+ + ++L+ Q QE+ +    + +QL +   E + +  +L++     +KR  
Sbjct: 485 QSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVH 544

Query: 432 MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQI 491
            L++  M+  +E    KE+L                + E  L +LH  K++ E+++   +
Sbjct: 545 QLEDDKMDITKELDVQKEKL---------------IQSEVALNDLHLTKQKLEDKVENLV 589

Query: 492 RE-----------EKARTRELETLQQTVEELQ------AQVHSMDGAKGWFERRLKEAEE 534
            +           +K      E ++Q  EEL        Q  + D    + +  LKE E 
Sbjct: 590 DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649

Query: 535 SLQ--QQQQEQEEALKQCREQHAAELKGKEEEL----QDVRDQLE-------QAQEERDC 581
            ++  +Q   + E L +  ++ A ++K + E+L    +DVR QLE       Q   E++ 
Sbjct: 650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709

Query: 582 HLKTISSLKQEVKDTV--DGQRILEK--KGSAALKDLKRQLHLERKRADKLQERLQDILT 637
            ++T+   K E++  +    +R+LE+  K    +++L    +L         E L  I  
Sbjct: 710 IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL--IKL 767

Query: 638 NSKSRSGLEELVLS-EMNSPSRTQTGD---SSSISSFSYREILREKESSAVPARSLSSSP 693
           N K    + EL  + E       +T D   SS        +++ +KE      +  SS  
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827

Query: 694 QAQPPRPAE-LSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIET 752
           Q +  + ++ L   E+  L Q + E  +    ++E+  HL+     + E+  R + + + 
Sbjct: 828 QEELDKYSQALRKNEI--LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP 885

Query: 753 YVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKD 812
             +DS  +++     ++ S L ++         E+L E  K  Q ++E+Q    M L + 
Sbjct: 886 KTLDSVTELA-----SEVSQLNTI--------KEHLEEEIKHHQKIIEDQNQSKMQLLQS 932

Query: 813 MEVLSQEI 820
           ++   +E+
Sbjct: 933 LQEQKKEM 940



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 180/914 (19%), Positives = 355/914 (38%), Gaps = 152/914 (16%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            EEE +  Q  + +   +  QL   L++   E+   R    Y  ++ +     L   K  +
Sbjct: 909  EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFR----YQHEQMNATHTQLFLEKD-E 963

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGV 126
            E++ L    E ++ +LH + +D +  NS +  E     ++++ L  EN   K   + A  
Sbjct: 964  EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE-----TKVQSLNIENGSEKHDLSKAET 1018

Query: 127  AQAGPLVDG------ELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
             +   LV G      E+  L  +N +L K +  L +    E GK + + + Q D      
Sbjct: 1019 ER---LVKGIKERELEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQ-QKDLEIQAL 1071

Query: 181  PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
               ++     +  +  + + +   +  E++  + + K  E S L+ E  K+ + +  K+ 
Sbjct: 1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA 1131

Query: 241  SFCRLQTEKETL-----------FNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN 289
            +  +LQ E + L           F ++   +  + + K+ +  A   + Q L   L+ ++
Sbjct: 1132 ALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSS 1191

Query: 290  -------------QSLAELRDQ--RQGERLEH-AAALRALQDQVSIQSADAQEQVEGLLA 333
                         + L + RD+  +Q +++E     +      +  +SA  QE++  L A
Sbjct: 1192 TGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251

Query: 334  E-------NNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDD 386
            +       N+ L+     L Q       +L    ++   +   + Q     + L+G+ D 
Sbjct: 1252 QVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDI 1311

Query: 387  LNSQLQESLRANSRLLEQLQE-----IGQEKEQLTQELQEARKSAEKRKAML-------- 433
            ++ QL  +     +  E L+      + +  E L QEL+E RKS +++ A +        
Sbjct: 1312 ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNH 1371

Query: 434  ---DELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL------------RELHE 478
               D +A  +  E+ +H++    ++   EK+ +  +   E++L             E   
Sbjct: 1372 RLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFT 1431

Query: 479  DKKRQEEELR-----------------GQIREE--------KARTRELETLQQT------ 507
            +K  + E LR                 G+++ E        + +  E + LQ+T      
Sbjct: 1432 NKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM 1491

Query: 508  -VEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQ 566
             + E + + HSM      FE+ LKE E+    +  +   A+K  +E        K    Q
Sbjct: 1492 MLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQE--------KTVVFQ 1543

Query: 567  DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRAD 626
              RDQ+  A +++      + +  Q ++D        E + +  L+ L+   HL      
Sbjct: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRN--HLLESEDS 1594

Query: 627  KLQERLQDILTNSKSR---SGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSA 683
              +E L      +K R   + LEE ++S  N+        S  + S   +  +  K+   
Sbjct: 1595 YTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDE 1654

Query: 684  VPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLE---EKVKHLEVSSASMA 740
               +   S  Q +    +  + + V E FQ     Q+EK M     EK K L       A
Sbjct: 1655 TALQLSVSQEQVKQYALSLANLQMVLEHFQ-----QEEKAMYSAELEKQKQLIAEWKKNA 1709

Query: 741  EDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLE 800
            E+L  K   ++  + ++   +  A+  T++        D+ +   E L+  N+  Q ML+
Sbjct: 1710 ENLEGKVISLQECLDEANAALDSASRLTEQ-------LDVKEEQIEELKRQNELRQEMLD 1762

Query: 801  EQLTKNMHLHKDME 814
            +   K M L    E
Sbjct: 1763 DVQKKLMSLANSSE 1776



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 156/795 (19%), Positives = 336/795 (42%), Gaps = 111/795 (13%)

Query: 13   MQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL-----SKSKKAQE 67
            + ++L +LR N      EL ++  E  +L  ++  LD++  +A K +       SK+  E
Sbjct: 465  LDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524

Query: 68   VEVLLSENEM----LQAKLHSQEEDFRLQNSTLMAEFSKLCSQ---MEQLEQENQQLKEG 120
             + ++S+ +      + ++H  E+D       L  +  KL      +  L    Q+L++ 
Sbjct: 525  GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
                       LVD +L + Q  N ++QK    L+E   +   + S +           +
Sbjct: 585  VEN--------LVD-QLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDS 635

Query: 181  PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
             +      L E E        E R L + L  LE        +L E L K++  +K + E
Sbjct: 636  NSNFKDTLLKEREA-------EVRNLKQNLSELE--------QLNENLKKVAFDVKMENE 680

Query: 241  SFC------RLQTEKETLFNDS----RNKIEELQQRKEADHKAQLARTQK-LQQELEAAN 289
                     R Q E+    N+     +N I E  + ++ + +A+L   +K L +E     
Sbjct: 681  KLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE 740

Query: 290  QSLAELRDQRQ----GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAAL 345
            +++ EL + R       +LEH   ++ L  +  ++ A+ ++ +E +  ++   +  L++ 
Sbjct: 741  KTIEELSNARNLNTSALQLEHEHLIK-LNQKKDMEIAELKKNIEQMDTDHKETKDVLSSS 799

Query: 346  EQIQTAKTQELN---MLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLL 402
             + Q   TQ +N   +  E+    +++LQ++  +Y   + + + L   ++E  R+   + 
Sbjct: 800  LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMK 859

Query: 403  EQLQEIGQEKEQLTQELQEARKSAE-KRKAMLDELAMETLQEKS--QHKEELGAVRLRHE 459
            E+   + +E E+L +E       A+ K    + ELA E  Q  +  +H EE     ++H 
Sbjct: 860  EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEE----EIKHH 915

Query: 460  KEVLGVRARYERELRELHEDKKRQEEELRGQIREEKA--------RTRELETLQQTVEEL 511
            ++++  + + + +L +  +++K++ +E R Q  +  A        +  E+++LQ+T+E++
Sbjct: 916  QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI 975

Query: 512  QAQVH--------------------SMDGAKGWFERRLKEAE-ESLQQQQQEQEEALKQC 550
            + Q+H                    S++   G  +  L +AE E L +  +E+E  +K  
Sbjct: 976  KTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035

Query: 551  REQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA 610
             E++ +  K  ++  +D   +L Q  +++D  ++ + +       T D   + ++  + A
Sbjct: 1036 NEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYA 1095

Query: 611  LKDLKRQLHLERKRADKLQ-----ERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSS 665
            ++  K    L  K  +         ++ DI+         +E  L ++   ++  +    
Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIV-------AAKEAALIKLQDENKKLSTRFE 1148

Query: 666  SISSFSYRE-------ILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAET 718
            S     +RE       I+REK+   + A S          + +   +E       +  E 
Sbjct: 1149 SSGQDMFRETIQNLSRIIREKDIE-IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEEL 1207

Query: 719  QQEKWMLEEKVKHLE 733
             QE+  L+++VK +E
Sbjct: 1208 LQERDKLKQQVKKME 1222



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 145/701 (20%), Positives = 283/701 (40%), Gaps = 124/701 (17%)

Query: 14   QAQLLELRTNNYQLSDELRKNGVELTS---------LRQKVAYLDKEFSKAQKALSKSK- 63
            +A L++L+  N +LS     +G ++           +R+K   +D    K Q  L+  + 
Sbjct: 1130 EAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQT 1189

Query: 64   ----------KAQEVEVLLSENEMLQAKLHSQEE----------DFRLQNSTLMAEFSKL 103
                       + + E LL E + L+ ++   EE          + + +++ L  E  +L
Sbjct: 1190 SSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQL 1249

Query: 104  CSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAG 163
             +Q+      N +L+    G  + Q+    + +L     E   +Q ++  L        G
Sbjct: 1250 QAQVLVDSDNNSKLQVDYTG--LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLG 1307

Query: 164  KFSAVSEGQGDPPGGPAPTVLAPMPLAEVEL-KWEMEKEEKRLLWEQLQGLESSKQAETS 222
            K   +S      P   + ++L P     +   K E+  E   LL ++L+ L  S Q + +
Sbjct: 1308 KLDIIS------PQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDA 1361

Query: 223  ----------RLQEELAKLSE--------------KLKKKQESFCRLQTEKETLFN---- 254
                      RL + +A  SE              +LK+KQ+   +L  EK+ L      
Sbjct: 1362 TIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD 1421

Query: 255  -------DSRNKIEELQQRKEA--DHKAQLARTQKLQQELEAANQSLAELRDQRQGERLE 305
                   +  NK+ E +  ++A  + K ++   +    +L+  N+ + E     +G+  E
Sbjct: 1422 QLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY---RGKETE 1478

Query: 306  HAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTG 365
            + A L+    + S+   + + +   +  +  A    L   EQ    KT ELN L      
Sbjct: 1479 YQA-LQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ---GKTGELNQLLNAVKS 1534

Query: 366  LAAELQQQQAEYEDLM---GQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEA 422
            +  +    Q E + +M    QK   N+ LQ  ++   RL ++     QE E+L   L E+
Sbjct: 1535 MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQ---RLRDKEFRSNQELERLRNHLLES 1591

Query: 423  RKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKR 482
              S  +     + LA E  + K + K     V +  EK V    A     +         
Sbjct: 1592 EDSYTR-----EALAAEDREAKLRKK-----VTVLEEKLVSSSNA-----MENASHQASV 1636

Query: 483  QEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAK-GWFERRLKEAEESLQQQQQ 541
            Q E L+ Q+    ++ R+   LQ +V + Q + +++  A         ++ E+++   + 
Sbjct: 1637 QVESLQEQLNVV-SKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAEL 1695

Query: 542  EQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 601
            E+++ L    +++A  L+GK   LQ+  D+   A       L + S L +++ D  + Q 
Sbjct: 1696 EKQKQLIAEWKKNAENLEGKVISLQECLDEANAA-------LDSASRLTEQL-DVKEEQ- 1746

Query: 602  ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSR 642
                     +++LKRQ  L ++  D +Q++L  +  +S+ +
Sbjct: 1747 ---------IEELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score =  117 bits (292), Expect = 6e-26
 Identities = 187/884 (21%), Positives = 377/884 (42%), Gaps = 116/884 (13%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
            L+EE FQR+ A              E  +   EL  LR+ +  ++      ++ L  + +
Sbjct: 262  LTEENFQRLHA--------------EHERQAKELFLLRKTLEEMELRIETQKQTL--NAR 305

Query: 65   AQEVEVLLSENEMLQAK---LHSQEEDFRLQNSTLMAEF--SKLCSQMEQLEQENQQLKE 119
             + ++ LL   EMLQ+K     + EED         AE     L S +EQ E+EN  L+E
Sbjct: 306  DESIKKLL---EMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLRE 362

Query: 120  GAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGD----- 174
                              +  + EN        ALQ     +  K S++  G  D     
Sbjct: 363  E-----------------MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI 405

Query: 175  ---PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAE-------TSRL 224
                  G   T      + ++E+     K  K  + EQL+   SSK+A+        + L
Sbjct: 406  QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV-EQLKEELSSKEAQWEELKKKAAGL 464

Query: 225  QEELAKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-DHKAQLARTQ- 279
            Q E+ ++ ++L +K      LQT+ ETL   F+DS+  IE L++   A + +A + +T+ 
Sbjct: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 524

Query: 280  -----KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADA---QEQVEGL 331
                 +L+++    N+   +++D  + E+   A  +  L+D + ++       Q+++E L
Sbjct: 525  DALRLRLEEKETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583

Query: 332  LAENNALRTSLAAL-EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQ 390
              +       +++L E++++ +    N     TT L   L +++   E L  Q+D    +
Sbjct: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTT-LEEALAEKERTIERLKEQRDRDERE 642

Query: 391  LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 450
             QE +       + L+++ ++   L  +L E   S    K     LA   L++ S+ K  
Sbjct: 643  KQEEI---DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699

Query: 451  LGAVRLRHEKEVLGVRARYERELRELHED--KKRQEEELRGQIRE-EKARTR---ELETL 504
               + L  +KE      + E +L++ HE   + R   E+  +I+  E+  TR   E    
Sbjct: 700  --EIALEQKKEEC---LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754

Query: 505  QQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQE------QEEALKQCREQHAAEL 558
            Q  V+ L   +  ++  K   ++++ E E  ++ Q ++      +E+  K+   Q   E 
Sbjct: 755  QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814

Query: 559  KGKEEELQDVRDQLEQAQEERDCHLKTI-SSLKQEVKDTVDGQRILEKKGSAALKDLKR- 616
            + +E+ L D   QL+ +  ++D  ++ +  +L++ V+ T + + +L ++ SA     K+ 
Sbjct: 815  RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874

Query: 617  -QLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREI 675
             +L +  ++  +  E ++  L++++     +E  L+ + +  R    +   +   +    
Sbjct: 875  EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAA 934

Query: 676  LREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVK--HLE 733
            + EK+++ +    LSSS +      A L  E+   + Q   +TQ    ++ +  +  H +
Sbjct: 935  ISEKDAN-IALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFK 993

Query: 734  VSSASMAEDLCRKSAIIETYVM--DSRIDVSVAAGHT-----DRSGLGSVLRDLVKPGDE 786
             S ++          II+  +    +R  + +  GH      DR  L  +LR L  P   
Sbjct: 994  SSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPL--ILRGLTPPASY 1051

Query: 787  NL--------REMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVR 822
            NL         E+ K  +  L+++L K    + +++  +  I++
Sbjct: 1052 NLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQ 1095



 Score =  102 bits (255), Expect = 1e-21
 Identities = 169/793 (21%), Positives = 319/793 (40%), Gaps = 106/793 (13%)

Query: 13  MQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA------Q 66
           +Q QL E+   N  L  ++     +L+S    +        K ++AL K + +      +
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213

Query: 67  EVEVLLSENEMLQAKLHSQEEDFRLQNST---------------LMAEFSKLCSQMEQLE 111
           +  V+  EN+ +Q  + + +++ R+Q                   +AE ++   Q    E
Sbjct: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273

Query: 112 QENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEG 171
            E Q  +       + +    ++ +   L A + +++K +  LQ +     G  +  +E 
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEE 328

Query: 172 QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQAETSRLQEELA 229
             +     A    A M +  +E   E +++E  +L E++      +   A+T  LQ  + 
Sbjct: 329 DHERTRRLAE---AEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIE 385

Query: 230 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKE------ADHKAQLARTQKLQQ 283
               K+   +     L+ E + L ++     EE ++  +      +  K    + ++L++
Sbjct: 386 MKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKE 445

Query: 284 ELEAANQSLAELRDQRQGERLE-------------HAAALRALQDQVSIQSADAQEQVEG 330
           EL +      EL+ +  G + E                AL+   + ++ Q +D+++ +E 
Sbjct: 446 ELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV 505

Query: 331 LLAENNA-------LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ 383
           L     A       L+T + AL      K   LN   +Q   +A E   Q  E  DL   
Sbjct: 506 LKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL--- 562

Query: 384 KDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAM---ET 440
           KD L+ + +  +    + +E LQE  ++KE+    L+E  KS +      D       E 
Sbjct: 563 KDMLDVK-ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621

Query: 441 LQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRE 500
           L EK +  E L   R R E+E       Y+++L++L    K +   L+G + E++A   +
Sbjct: 622 LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDL----KEKVSLLQGDLSEKEASLLD 677

Query: 501 LETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKG 560
           L+          A   +  G K   + RLK  E +L+Q+++E  +   Q ++ H A L+ 
Sbjct: 678 LKE--------HASSLASSGLKK--DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727

Query: 561 K------------EEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGS 608
           +            E E+   +D+  +AQ E D  L+ +  ++ E  D        +KK  
Sbjct: 728 RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK-------DKK-- 778

Query: 609 AALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSIS 668
             + +L+RQ+  + K+   L+ + Q  +   KS   LEE    E N    +Q    S   
Sbjct: 779 --IAELERQVKDQNKKVANLKHKEQ--VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834

Query: 669 SFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEK 728
                E L E    +V   +      AQ       ++++V EL   + + +QE   LE  
Sbjct: 835 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQE---LESM 891

Query: 729 VKHLEVSSASMAE 741
              L  +  S+AE
Sbjct: 892 KAKLSSTQQSLAE 904



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 98/498 (19%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            +EE    +  L +L+     L  +L +    L  L++  + L      A   L K  + +
Sbjct: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL------ASSGLKKDSRLK 697

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFS-KLCSQMEQLEQENQQLKEGAAGAG 125
             +E+ L + +    K+ SQ +  +   + L A  S ++  +++ LE+E  + K+ ++ A 
Sbjct: 698  TLEIALEQKKEECLKMESQLK--KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755

Query: 126  VAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLA 185
             A+   L++  L  ++ E     K +A L ER  K+  K                     
Sbjct: 756  -AEVDRLLE-ILKEVENEKNDKDKKIAEL-ERQVKDQNK--------------------- 791

Query: 186  PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
               +A ++ K ++EK++   + E+ +  E +    + +LQ+ L K  +++++ +E+    
Sbjct: 792  --KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 849

Query: 243  CRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGE 302
             ++  E+E +        E  +   E   +  L   +K++QELE+    L+  + Q   E
Sbjct: 850  VQITAEREMVLAQE----ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ-QSLAE 904

Query: 303  RLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT--QELNMLR 360
            +  H   LRA + +   +  + ++  E LLA  +    ++A LE   + K   +E+  L+
Sbjct: 905  KETHLTNLRAERRKHLEEVLEMKQ--EALLAAISEKDANIALLELSSSKKKTQEEVAALK 962

Query: 361  EQTTGLAAELQQQQAEYEDLMGQK-DDLNSQLQESLRANSR-----LLEQLQEIGQEKEQ 414
             +   L  +L+QQ      LM    +D + +   S + N +     +++ L E+ Q + +
Sbjct: 963  REKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSK 1022

Query: 415  LTQ---------------------------------------------ELQEARKSAEKR 429
            L                                               +LQ+  +  E+ 
Sbjct: 1023 LKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERD 1082

Query: 430  KAMLDELAMETLQEKSQH 447
             A L E A   LQ+ + H
Sbjct: 1083 NAELQEFANAILQQIADH 1100



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 53/280 (18%), Positives = 122/280 (43%), Gaps = 35/280 (12%)

Query: 486 ELRGQIREEKARTRELETLQQTVEELQAQVHS-MDGAKGWF------ERRLKEAEESLQQ 538
           +L+ Q++E     RE + L++ VE  ++++ S M+  K ++      ER L++ E S   
Sbjct: 153 DLQTQLKEV---LRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKIT 209

Query: 539 QQQEQEEALKQCREQHAAELKGKEEELQDVRD--QLEQAQEERDCHLKTISSLKQEVKDT 596
             +EQ   +++  +     ++  ++EL+  RD  QL Q           ++ L +E    
Sbjct: 210 IWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269

Query: 597 VDGQRILEKKG----SAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSE 652
           +  +   + K        L++++ ++  +++  +   E ++ +L   +S+ GL      E
Sbjct: 270 LHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK-GLSAKATEE 328

Query: 653 MNSPSRTQTGDSSSISSFSYREILREKESSAVPA---RSLSSSPQAQPPRP----AELSD 705
            +  +R        +         +EKE+S +     R   ++P +   +      E+ D
Sbjct: 329 DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD 388

Query: 706 EEVAELFQRLAETQQEKWML-----------EEKVKHLEV 734
            +++ + + L + ++E  ML           EE++K +EV
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  117 bits (292), Expect = 6e-26
 Identities = 146/710 (20%), Positives = 307/710 (43%), Gaps = 99/710 (13%)

Query: 7   EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KA 65
           EE  +   A  LEL  N    ++EL+K   EL   ++K+   + E S+ Q  + + K K 
Sbjct: 200 EELTKERDALSLELYRNTIT-NEELKKKNAEL---QEKLPLAESEKSEIQLNVKELKRKL 255

Query: 66  QEVEVLLSE--NEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG 123
           +  + LL +     LQ ++  QEE+ R Q   +  +  K+  Q E+L ++  +++E    
Sbjct: 256 ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK 315

Query: 124 AGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTV 183
               +       + LR Q +    QK +   +E+  ++  K     E   +         
Sbjct: 316 MWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE------- 368

Query: 184 LAPMPLAEVELKWEMEKE------------------------------EKRLLWEQLQGL 213
                  + E  WE EK+                              E+  +WEQ++ +
Sbjct: 369 --EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426

Query: 214 ESSK----QAETSRLQEELAKLSEKL----KKKQESFCRLQTEKETLFNDSRNKIE---- 261
              K    Q + +R QEE  +  E++    KK +E    ++ ++E +     N  E    
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486

Query: 262 ELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQR----QGERLEHAAALRALQDQV 317
           E QQ++  + K +L   +K+Q++ E   +   ++RDQ     Q +++     +R  +DQ+
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546

Query: 318 SIQSADAQEQVEGLLAENNALRTSLAALEQI---QTAKTQELNMLREQTTGLAAELQQQQ 374
             Q    ++Q + +  +   +       E+    Q  K +E   +RE+   +  E +  +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606

Query: 375 AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQL---------TQELQEARKS 425
            + E +  Q++ +  Q ++      ++ EQ +++ +++E++          Q L E ++ 
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666

Query: 426 AEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEE 485
             + + M ++  M+  +EK   +E++       EK+        E E     E K R+EE
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726

Query: 486 ELRGQIREEKARTRELETLQQTVEELQAQVHSM--DGAKGWFERRLKEAEESL------Q 537
           E+  + +EEK + +E E +Q+  EE+  Q   M     K W ++RL E +E L      Q
Sbjct: 727 EMMRE-QEEKMQEQE-EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 784

Query: 538 QQQQ--EQEEALKQCREQHAAE----------LKGKEEELQDVRDQLEQAQEERDCHLKT 585
           +Q++  EQEE ++   E+   +          ++G+EE++    +++   +E+     + 
Sbjct: 785 EQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK 844

Query: 586 ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDI 635
           +   ++++++ + GQ   E+K     + ++ Q    R++ +K++ + + I
Sbjct: 845 MWGQEEKMEEKMQGQ---EEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891



 Score =  110 bits (276), Expect = 4e-24
 Identities = 126/572 (22%), Positives = 268/572 (46%), Gaps = 77/572 (13%)

Query: 187 MPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQ 246
           +PLAE E K E++   K L  +  +      Q +T+ LQEE+ +  E+L+++++   +++
Sbjct: 234 LPLAESE-KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK---KIR 289

Query: 247 TEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEH 306
            ++E ++       E+  + +E + K      +  +QE E   Q   ELR+Q++      
Sbjct: 290 KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE-KELREQKE------ 342

Query: 307 AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGL 366
              LR  ++Q+       QEQ E +  +   +R     + + +    ++   +REQ    
Sbjct: 343 ---LREQEEQM-------QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ---- 388

Query: 367 AAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE-------- 418
               +Q+  + E+ M ++D+   + +E +R   ++ EQ++++ +EK+   QE        
Sbjct: 389 ----EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE 444

Query: 419 -LQEARKSAEKRKAMLDEL-AMETLQEKSQHKEE---------LGAVRLRHEKEVLGVRA 467
            +QE  +  E+ K M +E   M   +EK Q +EE             RL  +KE L  + 
Sbjct: 445 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504

Query: 468 RYERELREL--HEDKKRQEEELRGQI----REEKARTRELETLQQTVEELQAQVHSMDGA 521
           + + +  ++   E+K R +EE+ GQ     R+EK R +E +  +Q  E+++ Q   M   
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE-EKMRDQEQKM--- 560

Query: 522 KGWF-ERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERD 580
             W  E R+++  +  +++  +QEE +++       E K +EEE + +R+Q E+ QE+ +
Sbjct: 561 --WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE-EMMREQEEKMQEQEE 617

Query: 581 CHLKTISSL-KQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERL--QDILT 637
              +    + +QE K     +++ E++     ++ K     E++R  + +E+L   + + 
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW---EQQRLPEQKEKLWEHEKMQ 674

Query: 638 NSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQP 697
             +     EE +  +     +TQ  +  +      +E +RE+ES     + +    +   
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD----QEKMREEESMREREKKMREEEEMMR 730

Query: 698 PRPAELSDEEVAELFQRLAETQQEKWMLEEKV 729
            +  ++ ++E     +++ E ++E W  EEK+
Sbjct: 731 EQEEKMQEQE-----EKMQEQEEEMWEQEEKM 757



 Score =  102 bits (255), Expect = 1e-21
 Identities = 122/628 (19%), Positives = 272/628 (43%), Gaps = 65/628 (10%)

Query: 7   EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL-SKSKKA 65
           EEE +  + ++ +     ++  + LR+   ++    +K+   +K   + +K L  + K+ 
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337

Query: 66  QEVEVLLSENEMLQA---KLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
           +E + L  + E +Q    K+  QEE  R Q   +  +  +L  Q +Q+ ++ Q++++   
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397

Query: 123 GAGVA-------------------QAGPLVDGELLRLQAENTALQKNVAALQERYGKEAG 163
                                   Q   + + + ++ Q + T  Q+     +ER  +   
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457

Query: 164 KFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK----QA 219
           K     E   +                E E + +   E+K  LWEQ +  E  +    Q 
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517

Query: 220 ETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQ 279
           E  R QEE+    +K+ ++++       E+E    +   K+ + +Q+     +    +TQ
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEK-----MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572

Query: 280 KLQQELEAANQSLAELRDQRQGERL--EHAAALRALQDQVSIQSADAQEQVEGLLAENNA 337
           + +++     + + E    R+ E+   E    +R  ++++  Q    QEQ E +  +   
Sbjct: 573 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEK 632

Query: 338 LRTSLAAL-EQIQTAKTQELNMLREQTTGLAAEL---------QQQQAEYEDLMGQKDDL 387
           ++     + EQ +    QE  M  +Q      E          Q++  E E+ + +++ +
Sbjct: 633 MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM 692

Query: 388 NSQLQES---------LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAM 438
             + QE          +R    + E+ +++ +E+E + ++ ++ ++  EK +   +E+  
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752

Query: 439 ETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR--ELHEDKKRQEEELRGQIREEKA 496
           +  +   Q ++     RL  +KE L    + + + +  E  E  + QEE++RGQ  EEK 
Sbjct: 753 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ--EEKM 810

Query: 497 RTRELETLQQTVEELQAQVHSMDG--AKGW-FERRLKEAEESLQQQQQEQEEALKQCREQ 553
           R +E E ++   E++  Q   M G   K W  E ++   EE ++++ Q QEE +++  E 
Sbjct: 811 RGQE-EKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE- 868

Query: 554 HAAELKGKEEELQDVRDQLEQAQEERDC 581
              +++G+EE++++  +++   +E+  C
Sbjct: 869 ---KMRGQEEKMREQEEKMRGQEEKIYC 893



 Score =  100 bits (249), Expect = 6e-21
 Identities = 131/633 (20%), Positives = 288/633 (45%), Gaps = 60/633 (9%)

Query: 51  EFSKAQKALS-KSKKAQE-VEVLLSENEMLQAKLHSQ---EEDFRLQNSTLMAEFSKLCS 105
           E  +A  A+S + KKA   +E L  E + L  +L+      E+ + +N+ L  +     S
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239

Query: 106 QMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKF 165
           +  +++   ++LK     A       L   +   LQ E    ++ +   +++  K+  K 
Sbjct: 240 EKSEIQLNVKELKRKLERAKFL----LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295

Query: 166 SAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA-ETSRL 224
               E   +  G           + E E K  M ++EKRL  ++ +  E  K+  E   L
Sbjct: 296 WRQEERLREQEG----------KMREQEEK--MWRQEKRLREQEKELREQEKELREQKEL 343

Query: 225 QEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQE 284
           +E+  ++ E+ +K  E   +++ ++E ++       E+ +Q +E + K +  + +++ ++
Sbjct: 344 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR-DQEERMWEQ 402

Query: 285 LEAANQSLAELRDQ-RQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLA 343
            E   +    +R+Q +  E++E     + +Q+Q        ++Q E +  E         
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQ----EKKTRDQEEKMQEEERIREREKK 458

Query: 344 ALEQIQTAKTQELNMLREQTTGLAAE----LQQQQAEYEDLMGQKDDLNSQLQESLRANS 399
             E+ +T + QE  M +++      E     QQ+  E ++ + +++ +  Q ++      
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518

Query: 400 RLLEQLQEIGQEK---------EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 450
           ++ +Q +  GQEK         EQ  Q  ++  K  ++ + M D+   E +++K+Q +E+
Sbjct: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ--EERMEKKTQEQEK 576

Query: 451 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 510
               +    +E   +R R E+++RE  E  + QEE+++ Q  EEK + +E E + +  E+
Sbjct: 577 KTWDQEEKMREEERMRER-EKKMREEEEMMREQEEKMQEQ--EEKMQEQE-EKMWEQEEK 632

Query: 511 LQAQVHSMDGAKGWF-ERRLKEAEESLQQQQQ--EQEEALKQCREQHAAELKGKEEELQD 567
           +Q Q   M     W  E ++ E EE + +QQ+  EQ+E L +  +    E   ++EE   
Sbjct: 633 MQEQEEKM-----WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687

Query: 568 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 627
            ++++E+  +E++        +++E     +  R  EKK     + ++ Q    +++ +K
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREE-----ESMREREKKMREEEEMMREQEEKMQEQEEK 742

Query: 628 LQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660
           +QE+ +++    +     EE +  +   P + +
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 151/671 (22%), Positives = 278/671 (41%), Gaps = 140/671 (20%)

Query: 104 CSQMEQLEQENQQLKEGAAGAGVAQAG-----PLVDGELLRLQAENTALQKNVAALQERY 158
           C   E  +Q   QLKE    +   Q          D  +  L  + T L+  +   Q+  
Sbjct: 66  CHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAA 125

Query: 159 GK-EAGKFS-------AVSEGQGDPPGGPAPTVLAPMPLAEVELK----WEMEKEEKRLL 206
            K E G          A+S+     P G   T L P    ++  +    W    E +R L
Sbjct: 126 RKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRAL 185

Query: 207 WEQLQGLESSKQAETSRLQEELAK--------------LSEKLKKKQESFCRLQTEKETL 252
                   S++  +  R  EEL K               +E+LKKK           E+ 
Sbjct: 186 -----SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESE 240

Query: 253 FNDSRNKIEELQQRKE-ADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALR 311
            ++ +  ++EL+++ E A       +T  LQ+E+    +   ELR+Q +  R +     R
Sbjct: 241 KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE---ELREQEKKIRKQEEKMWR 297

Query: 312 ALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQ 371
             ++++  Q    +EQ E +  +   LR     L + Q  + +E   LREQ        +
Sbjct: 298 Q-EERLREQEGKMREQEEKMWRQEKRLREQEKELRE-QEKELREQKELREQE-------E 348

Query: 372 QQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKA 431
           Q Q + E +  Q++ +  Q ++  R   RL EQ +++ +E+EQ  ++ +E     ++R  
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM-REQEQKMRDQEERMWEQDERLR 407

Query: 432 MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQI 491
             +E   E  QEK   + E    ++R EK++       E+E +   +++K QEEE R + 
Sbjct: 408 EKEERMRE--QEKMWEQVE----KMREEKKM------QEQEKKTRDQEEKMQEEE-RIRE 454

Query: 492 REEKARTRELETLQQTVEELQAQVHSM--DGAKGWFERRLKEAEESL--QQQQQEQEEAL 547
           RE+K R  E ET+++  E++Q Q  +M     K W ++RL E +E L  Q++ QEQEE +
Sbjct: 455 REKKMREEE-ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513

Query: 548 KQCREQ--HAAELKGKEEEL---QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRI 602
            +  E+     E+ G+E+++   + +R+Q +Q  E+ +        ++ + +   D +  
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE-------KMRDQEQKMWDQEER 566

Query: 603 LEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTG 662
           +EKK              E+K  D+ ++  ++     + +   EE               
Sbjct: 567 MEKKTQEQ----------EKKTWDQEEKMREEERMREREKKMREE--------------- 601

Query: 663 DSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEK 722
                      E++RE+E                         E++ E  +++ E +++ 
Sbjct: 602 ----------EEMMREQE-------------------------EKMQEQEEKMQEQEEKM 626

Query: 723 WMLEEKVKHLE 733
           W  EEK++  E
Sbjct: 627 WEQEEKMQEQE 637


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  115 bits (289), Expect = 1e-25
 Identities = 196/920 (21%), Positives = 375/920 (40%), Gaps = 153/920 (16%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDEL-----RKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
            +EEF++ + +L +      +L +++      KN ++L    +  +  D E    Q   +K
Sbjct: 857  KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916

Query: 62   SK---KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLK 118
             +   K +EV     + E + A+L +++     + S L  +   L   + ++E+E    +
Sbjct: 917  IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976

Query: 119  EGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGG 178
                      AG  +D  + +L  E  ALQ+      +    E  K + +++ +      
Sbjct: 977  NKVKNLTEEMAG--LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK------ 1028

Query: 179  PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESS---KQAETSRLQEELAKLSEKL 235
                +     + ++E   E EK+ +  L    + LE      Q  T  ++ +  +L EKL
Sbjct: 1029 ----IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084

Query: 236  KKKQESFCRLQT---EKETLFNDSRNKIEELQQRKE------ADHKAQLARTQK----LQ 282
            KKK+     LQ+   +++ L    + KI+ELQ R E         +A  A+ +K    L 
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144

Query: 283  QELEAANQSL----------AELRDQRQGE-----------RLEHAAALRALQDQVSIQS 321
            +ELE  ++ L           E+  +R+ E            L+H A    L+ + +   
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204

Query: 322  ADAQEQVEGL-----------------------------LAENNALRTSLAALEQIQTAK 352
            A+  EQ++ L                              A+ N  +   A  +Q+   K
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK 1264

Query: 353  TQELNMLR--EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE----QLQ 406
            T+E    R     T   A LQ +  EY   + +KD L SQL    +A ++ +E    QL+
Sbjct: 1265 TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324

Query: 407  EIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVR 466
            E  + K  L   LQ +R           +L  E  +E+ + K EL     +   EV   R
Sbjct: 1325 EEIKAKSALAHALQSSRHDC--------DLLREQYEEEQEAKAELQRAMSKANSEVAQWR 1376

Query: 467  ARYE----RELRELHEDKKRQEEELRG---QIREEKARTRELE----TLQQTVEELQAQV 515
             +YE    +   EL E KK+  + L+     +    A+   LE     LQ  VE+L   V
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436

Query: 516  HSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQA 575
               + A    +++ +  ++ L + +Q+ EE   +  E    E +    EL  +++  E++
Sbjct: 1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL-EASQKESRSLSTELFKIKNAYEES 1495

Query: 576  QEERDCHLKTISSLKQEVKDTVD-----GQRILEKKGSAALKDLKRQLHLERKRADKLQE 630
             ++ +   +   +L+QE+ D  +     G+RI E      L+ +K+Q+  E+       E
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE------LEKIKKQVEQEKSELQAALE 1549

Query: 631  RLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKES--SAVPA-- 686
              +  L + + +    +L L+++ S    +  +         R  +R  ES  S + A  
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI 1609

Query: 687  RSLSSSPQAQPPRPAELSDEEV---------AELFQRLAETQQEKWMLEEKVKHLEVSSA 737
            RS + + + +     +L++ E+         AE  +    TQ    +L++   HL+ +  
Sbjct: 1610 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQA---ILKDTQLHLDDALR 1666

Query: 738  SMAEDLCRKSAIIE--TYVMDSRI-DVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKK 794
            S  EDL  + A++E    ++ + I ++      T+RS          K  ++ L + +++
Sbjct: 1667 SQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSR---------KIAEQELLDASER 1716

Query: 795  LQNMLEEQLTKNMHLHKDME 814
            +Q +L  Q T  ++  K +E
Sbjct: 1717 VQ-LLHTQNTSLINTKKKLE 1735



 Score =  104 bits (259), Expect = 4e-22
 Identities = 153/694 (22%), Positives = 288/694 (41%), Gaps = 110/694 (15%)

Query: 215  SSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ 274
            ++ + E  + +EELAK   K K+ +E    L  EK  L         +LQ + EAD  A 
Sbjct: 854  ANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL---------QLQVQAEADSLAD 904

Query: 275  LA----RTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 330
                  +  K + +LEA  + + E  +  +    E  A  R L+D+ S    D  +    
Sbjct: 905  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD---- 960

Query: 331  LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAEL-----------QQQQAEYED 379
                   L  +LA +E+ + A   ++  L E+  GL   +           +  Q   +D
Sbjct: 961  -------LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013

Query: 380  LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 439
            L  ++D +N+  +  ++   ++ +    + QEK+ +  +L+ A++  E    +  E  M+
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK-IRMDLERAKRKLEGDLKLAQESTMD 1072

Query: 440  TLQEKSQHKEELGAVRLRHEKEVLGVRARYERE----------LRELHEDKKRQEEELRG 489
               +K Q  E+L     + E E+ G++++ E E          ++EL    +  EEE+  
Sbjct: 1073 IENDKQQLDEKLK----KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1128

Query: 490  QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQ 549
            +        ++   L + +EE+  ++    GA        K+ E   Q+ +++ EEA  Q
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 550  CREQHAAELKGKE-EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEK-KG 607
              E  AA L+ K  + + ++ +Q++  Q  +    K  S +K E+ D       + K KG
Sbjct: 1189 -HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247

Query: 608  S--AALKDLKRQLHLERKRADKLQERLQDILTNSKSR----SGLEELVLSE----MNSPS 657
            +     + L+ QL  E K  ++ Q+RL + LT  ++R    SG     L E    ++  S
Sbjct: 1248 NLEKMCRALEDQLS-EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306

Query: 658  RTQTGDSSSISSFSYREILREKESSAVPARSLSSS----------------PQAQPPRPA 701
            R +   +  I     R++  E ++ +  A +L SS                 +A+  R  
Sbjct: 1307 RGKQAFTQQIEELK-RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365

Query: 702  ELSDEEVA--------ELFQRLAETQQEKWML-------EEKVKHLEVSSASMAEDLCRK 746
              ++ EVA        +  QR  E ++ K  L       EE V+ +    AS+ +   R 
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425

Query: 747  SAIIETYVMD-SRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNK------------ 793
               +E  ++D  R + + AA    +     +L +  +  +E   E+              
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485

Query: 794  -KLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
             K++N  EE L +   L ++ + L QEI  L+++
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQ 1519



 Score =  104 bits (259), Expect = 4e-22
 Identities = 173/812 (21%), Positives = 338/812 (41%), Gaps = 129/812 (15%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KA 65
            E + +  Q   +++  +  QL ++L+K   E++ L+ K+        + QK + + + + 
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119

Query: 66   QEVEVLLSENEMLQAKLHSQEEDF---------RLQ------------NSTLMAEFSKLC 104
            +E+E  +      +AK   Q  D          RL+            N    AEF K+ 
Sbjct: 1120 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179

Query: 105  SQMEQLEQENQQ----LKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGK 160
              +E+   +++     L++  A + VA+ G  +D     LQ     L+K  + ++     
Sbjct: 1180 RDLEEATLQHEATAATLRKKHADS-VAELGEQIDN----LQRVKQKLEKEKSEMKMEIDD 1234

Query: 161  EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAE 220
             A     VS+ +G+         L  M  A  +   E++ +E     E+ Q L +   A+
Sbjct: 1235 LASNMETVSKAKGN---------LEKMCRALEDQLSEIKTKE-----EEQQRLINDLTAQ 1280

Query: 221  TSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ------ 274
             +RLQ E  + S +L +K     +L   K+        +IEEL+++ E + KA+      
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAF----TQQIEELKRQLEEEIKAKSALAHA 1336

Query: 275  ---------LARTQ---------KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQ 316
                     L R Q         +LQ+ +  AN  +A+ R + + + ++    L   + +
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396

Query: 317  VSIQSADAQEQVEGLLAENNALR---------------------TSLAALEQIQTAKTQE 355
            ++ +  DA+E VE + A+  +L                       + AAL++ Q    + 
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456

Query: 356  LNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQL 415
            L   +++     AEL+  Q E   L  +   + +  +ESL     L  + + + QE   L
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516

Query: 416  TQELQEARKSAEKRKAMLDELAMETLQEKSQHKEEL--GAVRLRHEKEVLGVRARYEREL 473
            T+++ E  K   +    L+++  +  QEKS+ +  L      L HE+   G   R + EL
Sbjct: 1517 TEQIAEGGKRIHE----LEKIKKQVEQEKSELQAALEEAEASLEHEE---GKILRIQLEL 1569

Query: 474  RELHEDKKRQEEELRGQIREEKA-RTRELETLQQTVEELQAQVHSMDGA---KGWFERRL 529
             ++  +  R+  E   +I + K    R +E++Q T   L A++ S + A   K   E  L
Sbjct: 1570 NQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDL 1626

Query: 530  KEAEESLQQQQQEQEEALKQCREQHAAELKGKEEEL-------QDVRDQLEQAQEERDCH 582
             E E  L    +   EAL+  R   A  LK  +  L       +D+++QL   +   +  
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAI-LKDTQLHLDDALRSQEDLKEQLAMVERRANLL 1685

Query: 583  LKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN-SKS 641
               I  L+  ++ T   ++I E++    L D   ++ L   +   L    + + T+ S+ 
Sbjct: 1686 QAEIEELRATLEQTERSRKIAEQE----LLDASERVQLLHTQNTSLINTKKKLETDISQI 1741

Query: 642  RSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPA 701
            +  +E+++    N+  + +   +   ++    E+ +E+++SA   R   +  Q       
Sbjct: 1742 QGEMEDIIQEARNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799

Query: 702  ELSDEEVAELFQRLAETQQEKWMLEEKVKHLE 733
             L  +E  +L  +  + Q +K  LE +V+ LE
Sbjct: 1800 RL--DEAEQLALKGGKKQIQK--LEARVRELE 1827



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 141/619 (22%), Positives = 270/619 (43%), Gaps = 110/619 (17%)

Query: 1    MAQAL--SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
            +AQ L  +EE  + + A+   L     +L +E+    +++       A LDK+     K 
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456

Query: 59   LSKSKKAQEVEVLLSENEMLQAKLHS-QEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQL 117
            L++ K  Q+ E   +E E  Q +  S   E F+++N+     + +   Q+E L++EN+ L
Sbjct: 1457 LAEWK--QKCEETHAELEASQKESRSLSTELFKIKNA-----YEESLDQLETLKRENKNL 1509

Query: 118  KEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPG 177
            ++  +             +L    AE       +  ++++  +E  +  A  E       
Sbjct: 1510 QQEIS-------------DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE------- 1549

Query: 178  GPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 237
                           E +  +E EE ++L  QL+ L   K    S +  ++A+  E++ +
Sbjct: 1550 ---------------EAEASLEHEEGKILRIQLE-LNQVK----SEVDRKIAEKDEEIDQ 1589

Query: 238  KQESFCRLQTEKETLFND---SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAE 294
             + +  R+    ++  +    SRN    L+++ E D         +++ +L  AN+  AE
Sbjct: 1590 MKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD-------LNEMEIQLNHANRMAAE 1642

Query: 295  -LRDQRQGE------RLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ 347
             LR+ R  +      +L    ALR+ Q+ +  Q A  + +   L AE   LR +L   E+
Sbjct: 1643 ALRNYRNTQAILKDTQLHLDDALRS-QEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701

Query: 348  IQTAKTQEL-------NMLREQTTGLA-------AELQQQQAEYEDLMGQKDDLNSQLQE 393
             +    QEL        +L  Q T L         ++ Q Q E ED++ +  +   + ++
Sbjct: 1702 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKK 1761

Query: 394  SLRANSRLLEQL---QEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 450
            ++   + + E+L   Q+     E++ + L++  K  + R    ++LA++  +++ Q  E 
Sbjct: 1762 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE- 1820

Query: 451  LGAVRLRH-EKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVE 509
                R+R  E EV   + R    ++ L +  +R+ +EL  Q  E++   + +  LQ  V+
Sbjct: 1821 ---ARVRELEGEVESEQKRNVEAVKGLRK-HERKVKELTYQTEEDR---KNILRLQDLVD 1873

Query: 510  ELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVR 569
            +LQA+V S       ++R+ +EAEE      Q      K  R QH  EL+  EE      
Sbjct: 1874 KLQAKVKS-------YKRQAEEAEE------QSNVNLSKFRRIQH--ELEEAEERADIAE 1918

Query: 570  DQLEQAQ-EERDCHLKTIS 587
             Q+ + + + R+ H K IS
Sbjct: 1919 SQVNKLRVKSREVHTKIIS 1937



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 93/410 (22%), Positives = 195/410 (47%), Gaps = 26/410 (6%)

Query: 343  AALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLL 402
            A  E+      +E    +E+     A+ ++ + +   LM +K+DL  Q+Q    + +   
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906

Query: 403  EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ---EKSQHKEELGAVRLRHE 459
            E+  ++ + K QL  +++E  + AE  + +  EL  +  +   E S+ K+++  + L   
Sbjct: 907  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 966

Query: 460  KEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQ---VH 516
            K V   +   E +++ L E+    +E +    +E+KA     E  QQT+++LQA+   V+
Sbjct: 967  K-VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ---EAHQQTLDDLQAEEDKVN 1022

Query: 517  SMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQ 576
            ++  AK   E+++ + E SL+Q+++ + + L++ + +   +LK  +E   D+ +  +Q  
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMD-LERAKRKLEGDLKLAQESTMDIENDKQQLD 1081

Query: 577  EERDCHLKTISSLKQEVKDTVDGQRILEKK---GSAALKDLKRQLHLERKRADKLQERLQ 633
            E+       +S L+ +++D       L+KK     A +++L+ ++  ER    K +++  
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS 1141

Query: 634  DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSP 693
            D+     SR  LEE  +SE    +   T  S+ I     RE   +K    +   +L    
Sbjct: 1142 DL-----SRE-LEE--ISERLEEAGGAT--SAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

Query: 694  QAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDL 743
             A   R      + VAEL +++   Q+ K  LE++   +++    +A ++
Sbjct: 1192 TAATLRKKHA--DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1239


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  115 bits (287), Expect = 2e-25
 Identities = 171/852 (20%), Positives = 362/852 (42%), Gaps = 123/852 (14%)

Query: 4    ALSEEEFQRMQAQLLELRTNNYQLSDEL-----RKNGVELTSLRQKVAYLDKEFSKAQKA 58
            A  +E+F+R + +L        +L +++      KN ++L    +    +D E  +  + 
Sbjct: 854  ATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE--ERCEG 911

Query: 59   LSKSK-----KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQE 113
            L KSK     K +E+   L E E + ++L +++ +   + S+L  +   L   + ++E+E
Sbjct: 912  LIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKE 971

Query: 114  NQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAAL-QERYGKEAGKFSAVSEGQ 172
                                + ++  L  E TAL++N++ L +E+   +      + + Q
Sbjct: 972  KHA----------------TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015

Query: 173  --GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAK 230
               D   G          L ++  K E + ++       L+G    ++   + L+    K
Sbjct: 1016 VEEDKVNG----------LIKINAKLEQQTDD-------LEGSLEQEKKLRADLERAKRK 1058

Query: 231  LSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRK-----EADHKAQL--------AR 277
            L   LK  QES   L+ +K+ +    + K  EL Q +     E  H  Q         AR
Sbjct: 1059 LEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQAR 1118

Query: 278  TQKLQQELEAANQSLAELRDQRQ---------GERLEHAAALRALQDQVS-IQSADAQEQ 327
             ++L++E+EA +   A++  QR           ERLE A+   + Q +++  + A+ Q+ 
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178

Query: 328  VEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDL 387
               L         + A L + Q     EL    EQ   L    Q+ + E  +L  + DD+
Sbjct: 1179 RRDLEEATLQHEATAATLRKKQADSVAELG---EQIDNLQRVKQKLEKEKSELKMEIDDM 1235

Query: 388  NSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 447
             S ++   ++ S +    + +         +  E +   E++  ++ +L M+  + ++Q+
Sbjct: 1236 ASNIEALSKSKSNIERTCRTV-------EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQN 1288

Query: 448  KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 507
             E   + R+  ++ ++    + ++ L +  E+ KRQ EE      E KA+          
Sbjct: 1289 GEL--SHRVEEKESLISQLTKSKQALTQQLEELKRQMEE------ETKAK-------NAM 1333

Query: 508  VEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQD 567
               LQ+  H  D  +  +E   +EA+  LQ+   +    + Q R ++  +   + EEL++
Sbjct: 1334 AHALQSSRHDCDLLREQYEEE-QEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392

Query: 568  VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 627
             + +L Q  +E + + +T +S    ++ T   ++ L+ +    ++DL+R  H      DK
Sbjct: 1393 AKKKLAQRLQEAEENTETANSKCASLEKT---KQRLQGEVEDLMRDLERS-HTACATLDK 1448

Query: 628  LQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPAR 687
             Q     +L   K +    +  L      SR+ + +   + + +Y E++ + E+     +
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN-AYEEVVDQLETLRRENK 1507

Query: 688  SLSSSPQAQPPRPAELSD--EEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCR 745
            +L            E+SD  E++AE  + L E ++ K ++E++   L+V+   +   L  
Sbjct: 1508 NLQE----------EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557

Query: 746  KSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTK 805
            +    E+ ++  ++++S      DR  +     + ++    N +   + LQ++L+ ++  
Sbjct: 1558 E----ESKILRVQLELSQVKSELDRKVIEK--DEEIEQLKRNSQRAAEALQSVLDAEIRS 1611

Query: 806  N---MHLHKDME 814
                + L K ME
Sbjct: 1612 RNDALRLKKKME 1623



 Score =  102 bits (254), Expect = 1e-21
 Identities = 164/783 (20%), Positives = 325/783 (41%), Gaps = 115/783 (14%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KA 65
            E + +  Q  +++L  +  Q+ ++L+K   EL+ L+ K+        + QK + + + + 
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARI 1119

Query: 66   QEVEVLLSENEMLQAKLHSQEEDF---------RLQ------------NSTLMAEFSKLC 104
            +E+E  +     L+AK+  Q  D          RL+            N    AEF K+ 
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179

Query: 105  SQMEQLEQENQQ----LKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGK 160
              +E+   +++     L++  A + VA+ G  +D     LQ     L+K  + L+     
Sbjct: 1180 RDLEEATLQHEATAATLRKKQADS-VAELGEQIDN----LQRVKQKLEKEKSELKMEIDD 1234

Query: 161  EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAE 220
             A    A+S+ + +              +       E +  E +   EQ   L      +
Sbjct: 1235 MASNIEALSKSKSN--------------IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280

Query: 221  TSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK 280
             +RLQ +  +LS ++++K+    +L   K+ L      ++EEL+++ E + KA+ A    
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQAL----TQQLEELKRQMEEETKAKNAMAHA 1336

Query: 281  LQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRT 340
            LQ    ++      LR+Q + E+   A   RAL       S  AQ + +    E +A++ 
Sbjct: 1337 LQ----SSRHDCDLLREQYEEEQEAKAELQRALS---KANSEVAQWRTK---YETDAIQR 1386

Query: 341  SLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSR 400
            +   LE+ +    Q L    E T    ++    +   + L G+ +DL   L+ S  A + 
Sbjct: 1387 T-EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445

Query: 401  LLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR-LRHE 459
            L ++ +   +   +  Q+L E++   E  +     L+ E  + ++ ++E +  +  LR E
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE 1505

Query: 460  KEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVH--- 516
             + L      + E+ +L E      + L+   + +K   +E   LQ  +EE++  +    
Sbjct: 1506 NKNL------QEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559

Query: 517  --------SMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDV 568
                     +   K   +R++ E +E ++Q ++  + A +  +    AE++ + + L+ +
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR-L 1618

Query: 569  RDQLEQAQEERDCHLKTISSLKQEVKD---TVDGQRILEKKGSAALKDLKRQLHLERKRA 625
            + ++E    E +  L   +    E +    TV GQ          LKD   QLHL+   A
Sbjct: 1619 KKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ----------LKD--SQLHLDD--A 1664

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMN----SPSRTQTGDSSSISSFSYR-EILREKE 680
             +  E L++ L   + R+GL    L EM        RT+      +   S R ++L  + 
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724

Query: 681  SSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMA 740
            +S +  +              +  + ++A+    +  + QE    EEK K     +A MA
Sbjct: 1725 TSLINTK--------------KKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770

Query: 741  EDL 743
            E+L
Sbjct: 1771 EEL 1773



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 158/772 (20%), Positives = 316/772 (40%), Gaps = 134/772 (17%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKN--------GVELTSLRQKVAYLDKEFSKAQ-- 56
            E EFQ+M+  L E    +   +  LRK         G ++ +L++    L+KE S+ +  
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231

Query: 57   --------KALSKSK-------------------KAQEVEVLLSENEMLQAKLHSQEEDF 89
                    +ALSKSK                   K ++   L+ +  M +A+L +Q  + 
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291

Query: 90   RL---QNSTLMAEFSK----LCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQA 142
                 +  +L+++ +K    L  Q+E+L+++ ++  +       A      D +LLR Q 
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351

Query: 143  ENT---------ALQK---NVAALQERYG----------KEAGKFSAVSEGQGDPPGGPA 180
            E           AL K    VA  + +Y           +EA K  A    + +     A
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411

Query: 181  PTVLAPMPLAEVELKWEME-----------------KEEK---RLLWEQLQGLESSKQAE 220
             +  A +   +  L+ E+E                 K+++   ++L E  Q L+ S QAE
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES-QAE 1470

Query: 221  TSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKE--ADHKAQLART 278
                Q+E   LS +L K + ++  +  + ETL  +++N  EE+    E  A+    L   
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA 1530

Query: 279  QKLQQELEAANQSLAELRDQRQGERLEHAAA--------LRALQDQVSIQSADAQEQVEG 330
            +K ++ +E     L    ++ +G  LEH  +        L  ++ ++  +  +  E++E 
Sbjct: 1531 EKTKKLVEQEKSDLQVALEEVEGS-LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589

Query: 331  LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQ-----------QAEYED 379
            L   +     +L ++   +     +   L+++  G   E++ Q           Q     
Sbjct: 1590 LKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT 1649

Query: 380  LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAE--KRKAMLDELA 437
            + GQ  D    L ++LR+N  L EQL  + +    L +EL+E + + E  +R   L E  
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQE 1709

Query: 438  METLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKAR 497
            +    ++ Q         +  +K++    A+ + E+    ++ +  EE+ +  I +    
Sbjct: 1710 LLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMM 1769

Query: 498  TRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE-----------ESLQQQQQEQEEA 546
              EL+  Q T   L+    +++      + RL EAE           + L+ + +E E  
Sbjct: 1770 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENE 1829

Query: 547  LKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKK 606
            L   +++ A  LKG  +  + V++   QA+E+    L+        ++D VD  +   K 
Sbjct: 1830 LDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILR--------LQDLVDKLQAKVKS 1881

Query: 607  GSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSR 658
                 ++ + Q + +  R  ++Q  L++    +  R+ + E  ++++ + SR
Sbjct: 1882 YKRQAEEAEEQANTQLSRCRRVQHELEE----AAERADIAESQVNKLRAKSR 1929



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 149/697 (21%), Positives = 289/697 (41%), Gaps = 101/697 (14%)

Query: 210  LQGLESSKQAET-----SRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ 264
            L+  E+ K+  T      R +EELA+   + K+ +E    L  EK  L    +++ E L 
Sbjct: 844  LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903

Query: 265  QRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADA 324
               +A+ + +     K+   LEA  + L E  ++ +    E  A  R L+D+ S    D 
Sbjct: 904  ---DAEERCEGLIKSKIL--LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958

Query: 325  QE---QVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLM 381
             +    +  +  E +A    +  L +  TA  + ++ L ++   L    QQ     +DL 
Sbjct: 959  DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT---LDDLQ 1015

Query: 382  GQKDDLNSQLQESLRANSRLLEQLQEIG---QEKEQLTQELQEARKSAEKRKAMLDELAM 438
             ++D +N  +    + N++L +Q  ++    +++++L  +L+ A++  E    M  E  M
Sbjct: 1016 VEEDKVNGLI----KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIM 1071

Query: 439  ETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE-LRELHEDKKRQE-----EELRGQIR 492
            +   +K Q +E+L     + E E+  ++A+ + E +  L   KK +E     EEL  +I 
Sbjct: 1072 DLENDKQQIEEKLK----KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127

Query: 493  EEKARTRELET----LQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALK 548
             E     ++E     L + +EE+  ++    GA        K+ E   Q+ +++ EEA  
Sbjct: 1128 AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL 1187

Query: 549  QCREQHAAELKGKE-EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKG 607
            Q  E  AA L+ K+ + + ++ +Q++  Q  +    K  S LK E+ D       L K  
Sbjct: 1188 Q-HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSK 1246

Query: 608  SAALKDLK--RQLHLERKRADKLQERLQDILTNSKSRSGLE-----------ELVLSEMN 654
            S   +  +       E K  D+ Q +L   L   K+R   +           E ++S++ 
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT 1306

Query: 655  SPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSS----------------PQAQPP 698
               +  T     +     R++  E ++    A +L SS                 +A+  
Sbjct: 1307 KSKQALTQQLEELK----RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362

Query: 699  RPAELSDEEVA--------ELFQRLAETQQEKWMLEEKVKHLEVSS-------ASMAEDL 743
            R    ++ EVA        +  QR  E ++ K  L ++++  E ++       AS+ +  
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422

Query: 744  CRKSAIIETYVMD-SRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNK--------- 793
             R    +E  + D  R   + A     +     VL +  +  DE+  E+           
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482

Query: 794  ----KLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
                K++N  EE + +   L ++ + L +EI  L+++
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  114 bits (285), Expect = 4e-25
 Identities = 176/793 (22%), Positives = 341/793 (43%), Gaps = 100/793 (12%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q L  E+ +R    L        Q     ++  +E    R++V  L++E  + Q+   + 
Sbjct: 565  QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624

Query: 63   KKAQEVEVLLS---ENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKE 119
             + +  + LL    + E  Q +L  ++++ R Q      E  +L  ++++ E E ++ ++
Sbjct: 625  PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR-EHEEERREQ 683

Query: 120  GAAGAGVAQAGPLVDGELLR----LQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDP 175
              A     QA   +   + +    L++E  A Q  V +   R  K+ G+     + +   
Sbjct: 684  ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS---RPRKQEGQRRRQEQEE--- 737

Query: 176  PGGPAPTVLAPMPLAEVELKWE---------MEKEEKRLLWEQLQGLESSKQAETS---- 222
                           E EL+W+          E+E++R    Q Q  E S++        
Sbjct: 738  ----------KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787

Query: 223  ---RLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQ 279
               R Q E    +E+ +++++ F   + EKE      R + +ELQ  +E +   +  R Q
Sbjct: 788  PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847

Query: 280  KLQQELEAANQ------SLAELRDQRQGERLEHAAALR--------ALQDQVSIQSADAQ 325
            +LQ+E +   +      S  + RDQ+   +LE     R        ALQ+Q+  +    Q
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907

Query: 326  EQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 385
            E+ E L  E    R       Q +    +E  + +E+   L  E ++++ +  +   +KD
Sbjct: 908  EEEEELQREEREKRRRQEQERQYR----EEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 386  DLNSQLQESL---RANSRLLEQLQEIGQEKEQLTQELQEA-RKSAEKRKAMLDELAMETL 441
                Q +E L       R  ++ ++  +E+E+L QE ++  R+  EKR+    E      
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 442  QEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL 501
             E  Q +E+L    LR E+E   ++ R ER+ RE  E+ +++EE+L G+ RE + R +EL
Sbjct: 1024 DELQQEEEQL----LREEREKRRLQER-ERQYRE-EEELQQEEEQLLGEERETRRR-QEL 1076

Query: 502  ETLQQTVEELQAQVHSMDGAKGWFERRLKEA-----EESLQQQQQE--QEEALKQCREQH 554
            E   +  EELQ +   +   +    RR +       EE LQQ++++  +EE  K+ R++ 
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 555  AAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDL 614
              + + +EEE+Q   +QL + + E+    +     ++E +   + +++L ++     ++ 
Sbjct: 1137 ERQYR-EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195

Query: 615  KRQLHLERK-RADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYR 673
            +RQ   E + +  K ++R +D       RS L+     E  +  R          +  +R
Sbjct: 1196 ERQYREEEELQRQKRKQRYRD----EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251

Query: 674  EI----LREKESSAVPARSLSSSPQAQP--------------PRPAELSDEEVAELFQRL 715
            ++    LR+++S       L    +                 P   +L  EE  E  +R 
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311

Query: 716  AETQQEKWMLEEK 728
             ++Q+EK +L E+
Sbjct: 1312 RKSQEEKQLLREE 1324



 Score =  108 bits (269), Expect = 3e-23
 Identities = 126/549 (22%), Positives = 247/549 (44%), Gaps = 61/549 (11%)

Query: 197 EMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDS 256
           E +   + LL  + +G E  +Q    R      +  EK  +K+E+   L+ E+E L  + 
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV--LRKEEEKLQEEE 264

Query: 257 RNKIEELQQRKEADHKAQLARTQKLQQELEAANQSL---AELRDQRQGERLEHAAALRAL 313
             +  ELQ+ +E   K +    ++ +QE E   Q L    +LR +++ ER E     R  
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 314 QDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQ 373
           Q++   Q    ++Q   L  E    R      EQ +  + Q+L   +E+        ++Q
Sbjct: 325 QERREQQEERREQQ---LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381

Query: 374 QAEYEDLMGQKDDLNSQLQ----ESLRANSRL-----LEQLQEIGQEKEQLTQELQEARK 424
           Q   E  + ++  L  + Q    + LR   +L     L + Q++ +E+E+   E +  ++
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 425 SAEKRKAMLDELAMETL---QEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKK 481
             E+R     E   + L   +E  +H++E    +L+ ++E      R ER L+   E+++
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE----EERRERWLKLEEEERR 497

Query: 482 RQEEELRGQIREEKARTRELETLQQTVEE-LQAQVHSMDGAKGWFERRLKEAEESLQQQQ 540
            Q+E    Q+R E+   RE    +Q  EE LQ ++ S        E++L+  +E  ++Q 
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS--------EQQLRREQEERREQL 549

Query: 541 QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600
            ++EE  +  +E+    LK ++EE    RDQL + +EER         LK+E ++ ++ Q
Sbjct: 550 LKREEEKRLEQERREQRLKREQEER---RDQLLKREEER-----RQQRLKREQEERLE-Q 600

Query: 601 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660
           R+  ++     ++ +R+  L+R+  +  +ER Q +L + +     ++ +  E        
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPE--EERRQQLLKSEEQEERRQQQLRREQQERRE-- 656

Query: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRL-AETQ 719
                       + + RE+E   +  R      + +  R  EL++EE  +  +R+ +   
Sbjct: 657 ------------QRLKREEEEERLEQRLKREHEEER--REQELAEEEQEQARERIKSRIP 702

Query: 720 QEKWMLEEK 728
           + +W LE +
Sbjct: 703 KWQWQLESE 711



 Score =  103 bits (258), Expect = 5e-22
 Identities = 176/863 (20%), Positives = 353/863 (40%), Gaps = 103/863 (11%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q   EE+ Q+ + QLL       +  +  R+   +   L+QK   L  E  + ++   + 
Sbjct: 929  QYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQKEEQLLGEEPEKRRRQERE 987

Query: 63   KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAA 122
            KK +E E L  E E L   L  + E  R Q      E+ +   + ++L+QE +QL     
Sbjct: 988  KKYREEEELQQEEEQL---LREEREKRRRQ------EWERQYRKKDELQQEEEQL----- 1033

Query: 123  GAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPT 182
                           LR + E   LQ+     + +Y +E      + + +    G    T
Sbjct: 1034 ---------------LREEREKRRLQER----ERQYREE----EELQQEEEQLLGEERET 1070

Query: 183  VLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL------- 235
                    +   + E+++EE++LL E+ +     ++    R +EEL +  E+L       
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130

Query: 236  KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 295
            +++QE   + + E+E    + +   EE ++R+  + + Q    ++LQQE E   Q L E 
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE---QLLREE 1187

Query: 296  RDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL-----AENNALRTSLAALEQIQT 350
            +++R+ ER         LQ Q   Q    ++Q   L       + NA+R +    +  + 
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 351  AKTQEL--NMLREQTTG-----LAAELQQQQAEYEDLMGQKDDLNSQLQESL-RANSRLL 402
             + ++L  + LR++ +      L  E Q++  E E    Q+ D +   +E L R   +  
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307

Query: 403  EQLQEIGQEKEQLTQELQEARKSAEK--RKAMLDELAMETLQEKSQHKEE----LGAVRL 456
            ++     QE++QL +E +E ++  ++  RK   +E  ++  +E+   ++E         L
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367

Query: 457  RHEKEVLGVRARYERELRELHEDK-KRQEEELRGQIREEKARTRELETLQQTVEELQAQV 515
            RH+++        +R  R+  E K  ++E++LR Q RE++ R       ++  ++L  Q 
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427

Query: 516  HS-------MDGAKGWFERRLKEAEESLQQQQQE---QEEALKQCREQHAAELKGKEEEL 565
                         +   ER+  E E+ L+Q++     +EE L Q RE+     + ++ + 
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487

Query: 566  QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRA 625
             +   QL + + +R    + + S + E K   + Q++  ++        ++QL  + +  
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVP 685
             + Q+R +      + R   EE  LS      + +  +         R+ + +++     
Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ---- 1603

Query: 686  ARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQ------QEKWMLEEKVKHLEVSSASM 739
             R      Q +  R  +  ++E  +L Q   E Q        K++ EE     +     +
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDE--QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 740  AEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNML 799
              D  RK    E  + +   +  +     DR           +  ++ LR   ++ + + 
Sbjct: 1662 RHDRDRKFREEEQLLQEGE-EQQLRRQERDRK---------FREEEQQLRRQERERKFLQ 1711

Query: 800  EEQLTKNMHLH---KDMEVLSQE 819
            EEQ  +   L    ++ E L QE
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQE 1734



 Score =  103 bits (256), Expect = 9e-22
 Identities = 139/670 (20%), Positives = 287/670 (42%), Gaps = 70/670 (10%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK----- 61
            +E  +  + +  + R  ++   ++L +   +    R + +  +K+  + ++   +     
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334

Query: 62   SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGA 121
             +K +E E LL E E    +   ++  FR +      +  K   + ++L ++ ++ K   
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF-- 1392

Query: 122  AGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAP 181
                      L + + LR Q     L+      Q+R  K   +   +S  + D       
Sbjct: 1393 ----------LKEEQQLRCQEREQQLR------QDRDRKFREEEQQLSRQERDRKFREEE 1436

Query: 182  TVLAPMPLAEVELKWEME---------KEEKRLLWEQLQGLESSKQAETSRLQEELA-KL 231
              +         L+ E +         +EE++LL E+ +     ++ +   L+EE   + 
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496

Query: 232  SEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQS 291
             E+ +K +E   R Q  +     + +    + +QRK    + QL R ++ QQ  +  ++ 
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556

Query: 292  LAE---LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAA--LE 346
              E   LR +R+ ++L      R  +  +  Q    QEQ    + +   LR       L 
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFR--LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614

Query: 347  QIQTAKTQELNMLREQTTGLAAELQQQQAEY--EDLMGQKDDLNSQLQESLRANSRLLEQ 404
            Q +  K +E   L ++        Q++  ++  E+   ++ +   QL+       R  EQ
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674

Query: 405  LQEIGQEKE--------QLTQELQEARKSAEKRKAMLDE--LAMETLQEKSQHKEELGAV 454
            L + G+E++        +  +E Q+ R+   +RK + +E  L  + L+ K + +E+L   
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL--- 1731

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQ 514
            R   E+E L  + RY + L E     +R+E++LR Q R+ K R  E E L+Q  EE Q +
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR--EEEQLRQEREEQQLR 1789

Query: 515  VHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQ 574
                D       R+ +E EE L+Q+++EQ+       +Q   + + +EE+LQ + +Q ++
Sbjct: 1790 SQESD-------RKFRE-EEQLRQEREEQQLR----PQQRDGKYRWEEEQLQ-LEEQEQR 1836

Query: 575  AQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQD 634
             ++ERD   +       + K   + Q + +++     ++ +R+L  E  R  + +E+   
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHR 1896

Query: 635  ILTNSKSRSG 644
             +   KS+ G
Sbjct: 1897 QVGEIKSQEG 1906



 Score =  100 bits (250), Expect = 4e-21
 Identities = 137/589 (23%), Positives = 253/589 (42%), Gaps = 69/589 (11%)

Query: 191 EVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL--------------SEKLK 236
           E E +W   +   R   E+LQ  E  +Q E    +E+L KL               ++  
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300

Query: 237 KKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELR 296
           ++++   R Q E+     + R + +E ++++E   + QL R Q+ ++E +   +   E R
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360

Query: 297 DQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQEL 356
           +Q+     E     + L+ +  ++      + + L  E    R      EQ Q  + Q+L
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQL 419

Query: 357 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQE--KEQ 414
              REQ   L  E ++++ E +    +++    + QE  R   +  E+ +   QE  K+Q
Sbjct: 420 R--REQQ--LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475

Query: 415 LTQELQEARK------SAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRAR 468
           L ++ +E R+        E+R+   +    +  +E+ + +E+   ++ + E+E L  R R
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ--RLKRQEEEERLQQRLR 533

Query: 469 YERELRELHEDK-----KRQEEELRGQIREEKARTRELETLQQTV---EELQAQVHSMDG 520
            E++LR   E++     KR+EE+   Q R E+   RE E  +  +   EE + Q      
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593

Query: 521 AKGWFERRLKEAEESLQQQQQEQEEALK--QCREQHAAELKGKEEELQDVRDQLEQAQEE 578
            +   E+RLK  E    +Q++ +E+ LK  +  E+   +L   EE+ +  + QL + Q+E
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653

Query: 579 -RDCHLKTISS-------LKQEVKDTVDGQRILEKKGSAALKDLKR-----QLHLE---- 621
            R+  LK           LK+E ++    Q + E++   A + +K      Q  LE    
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713

Query: 622 --------RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYR 673
                   R R  + Q R Q+     K R    EL   E     R Q  +      F+++
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQE--QEEKRRRRESELQWQEEERAHRQQQ-EEEQRRDFTWQ 770

Query: 674 EILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEK 722
              + +E S    + LS+ P  +  R  +L  EE  +  QR    ++EK
Sbjct: 771 --WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 174/748 (23%), Positives = 317/748 (42%), Gaps = 119/748 (15%)

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQ-----ENQ 115
            + ++ +E ++   + E  + +L  QEE+ RLQ   L +E      Q E+ EQ     E +
Sbjct: 498  EQQERREQQLRREQEERREQRLKRQEEEERLQ-QRLRSEQQLRREQEERREQLLKREEEK 556

Query: 116  QLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDP 175
            +L++      + +       +LL+ + E    Q+ +   QE   ++  K   V   + + 
Sbjct: 557  RLEQERREQRLKREQEERRDQLLKREEERR--QQRLKREQEERLEQRLKREEVERLEQEE 614

Query: 176  PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 235
                      P      +L    E+EE+R   +QL+  +  ++ +  + +EE  +L ++L
Sbjct: 615  RREQRLKREEPEEERRQQLLKSEEQEERR--QQQLRREQQERREQRLKREEEEERLEQRL 672

Query: 236  KKKQESFCRLQTEKETLFNDSRNKI----------------------------EELQQRK 267
            K++ E   R Q   E     +R +I                            +E Q+R+
Sbjct: 673  KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732

Query: 268  EADHKAQLARTQKLQ-QELEAAN--------------QSLAELRDQRQGERLEHAAALRA 312
            +   + +  R  +LQ QE E A+              Q  AE + +R  +RL     LR 
Sbjct: 733  QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 313  LQDQVSIQSADAQEQVEGLLAE----------NNALRTSLAAL-EQIQTAKTQELNMLRE 361
             Q +  +++ + Q++ +  L E                 L  L E+ Q  + +    L+E
Sbjct: 793  -QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 362  QTTGLAAELQ----QQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 417
            +  GL  + +    Q+Q   +    Q ++   + + +L A   L EQL++  Q  ++  +
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911

Query: 418  ELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELH 477
            ELQ  R+  EKR+    E      ++  Q +E+L    LR E+E    R R ERE R+  
Sbjct: 912  ELQ--REEREKRRRQEQERQYREEEQLQQEEEQL----LREERE---KRRRQERE-RQYR 961

Query: 478  EDKKRQ--EEELRGQIREEKART------RELETLQQTVEELQAQVHSMDGAKGWFERRL 529
            +DKK Q  EE+L G+  E++ R       RE E LQQ  E+L  +       + W ER+ 
Sbjct: 962  KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW-ERQY 1020

Query: 530  KEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSL 589
            ++ +E  Q+++Q   E  ++ R Q       +EEELQ   +QL    EER+      +  
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL--LGEERE------TRR 1072

Query: 590  KQEVKDTVDGQRILEKKGSAALK-DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEEL 648
            +QE++     +  L+++    L+ + +++   ER+R  + +E LQ            EE 
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ----------EEEQ 1122

Query: 649  VLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAE---LSD 705
            +L E     R Q  +        YRE   E+E      + L   P+ +  +  E     +
Sbjct: 1123 LLREEREKRRRQELER------QYRE---EEEVQQEEEQLLREEPEKRRRQELERQYREE 1173

Query: 706  EEVAELFQRLAETQQEKWMLEEKVKHLE 733
            EE+ +  ++L   +QEK   E + ++ E
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYRE 1201



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 133/556 (23%), Positives = 257/556 (46%), Gaps = 68/556 (12%)

Query: 208 EQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ--- 264
           EQ +  E  +Q +  R  EEL +  ++ ++++E     + E+E L +   ++ EE     
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREER----RAEEEQLQSCKGHETEEFPDEE 208

Query: 265 --QRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSA 322
             +R+E     +  R +K QQ  E  ++   E   + + E  +    LR  +++  +Q  
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQE---EEEKEWRKRETVLR--KEEEKLQEE 263

Query: 323 DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLRE----QTTGLAAELQQQQAEYE 378
           + Q Q E  L E           EQ++  + QEL   R+    Q   L  E Q ++ + E
Sbjct: 264 EPQRQRE--LQEEE---------EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 379 DLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK--EQLTQELQEARKSAEKRKAMLDEL 436
           +   Q+++   Q +   +   R  +QL+   +E+  +QL +E +E R+  + R+   +E 
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372

Query: 437 AMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKA 496
             + L+ + Q + E    +LR E+++     R E++LR   E + R+E++LR   RE++ 
Sbjct: 373 REQQLRREQQLRREQ---QLRREQQL-----RREQQLRR--EQQLRREQQLR---REQQL 419

Query: 497 RTRELETLQQTVEELQAQVHSMDGAKGWFERR-------LKEAEESLQQQQQEQEEALKQ 549
           R RE +  ++  EE   Q H  +  +   +R        LK  EE+ + +Q+ +++ LK+
Sbjct: 420 R-REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 550 CREQHAAE--LKGKEEELQDVRDQLEQ-----AQEERDCHLKTISS---LKQEVKDTVDG 599
            +E+   E  LK +EEE ++ +++ EQ      +E R+  LK       L+Q ++     
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 600 QRILEKKGSAALK-DLKRQLHLERK--RADKLQERLQDILTNSKSRSGLEELVL-SEMNS 655
           +R  E++    LK + +++L  ER+  R  + QE  +D L   +     + L    E   
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598

Query: 656 PSRTQTGDSSSISSFSYRE-ILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQR 714
             R +  +   +     RE  L+ +E      + L  S + +  R  +L  E+     QR
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658

Query: 715 LAETQQEKWMLEEKVK 730
           L   ++E+  LE+++K
Sbjct: 659 LKREEEEE-RLEQRLK 673



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 181/837 (21%), Positives = 331/837 (39%), Gaps = 110/837 (13%)

Query: 2    AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
            A+  SE   QR+ A+         QL  E R+        +++  +L +E  K Q+   +
Sbjct: 773  AEEKSERGRQRLSARPPLREQRERQLRAEERQ--------QREQRFLPEEEEKEQRRRQR 824

Query: 62   SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQE-NQQLKEG 120
             ++ +E++  L E E LQ +  +Q+   + +   L  +  +  SQ ++ +Q+   QL+E 
Sbjct: 825  REREKELQ-FLEEEEQLQRRERAQQ--LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
                              R +  +T   K   ALQE+  KE                   
Sbjct: 882  ------------------RKRRRHTLYAK--PALQEQLRKEQ------------------ 903

Query: 181  PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
                    L E E + + E+ EKR   EQ +     +Q +    +E+L +   + +++QE
Sbjct: 904  ------QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE--EEQLLREEREKRRRQE 955

Query: 241  SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300
               + + +K+    + +   EE ++R+  + + +    ++LQQE E   Q L E R++R+
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE---QLLREEREKRR 1012

Query: 301  GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 360
             +  E     +    Q   Q    + +   L       R      E++Q  + Q L   R
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE----EELQQEEEQLLGEER 1068

Query: 361  EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE--QLQEIGQEKEQLTQE 418
            E  T    EL++Q  + E+L  +++ L  +  E  R   R  +  + +E+ QE+EQL +E
Sbjct: 1069 E--TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126

Query: 419  LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
             +E R+  E  +   +E   E  QE+ Q   E    R R E E    + R E EL++  E
Sbjct: 1127 EREKRRRQELERQYREE--EEVQQEEEQLLREEPEKRRRQELE---RQYREEEELQQEEE 1181

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK-------- 530
               R+E+E R Q RE + R  E    Q+  +  + +    D    W   +          
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 531  -EAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSL 589
             +  E+ Q +Q E  +   +  +Q    L G+++E    R+Q  +  ++RD H      L
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD--REQERRRWQQRDRHFPEEEQL 1299

Query: 590  KQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK-----------LQERLQDILTN 638
            ++E  +  + +R    + S   K L R+   E++R  +           LQER +  L  
Sbjct: 1300 ERE--EQKEAKR--RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355

Query: 639  SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP 698
             +      E  L       +    +         R+ L+E++      R      Q +  
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ----LRCQEREQQLRQD 1411

Query: 699  RPAELSDEEV----AELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYV 754
            R  +  +EE      E  ++  E +Q+    E + K LE     + ++  RK    E  +
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE-EEQQLRQERHRKFR-EEEQL 1469

Query: 755  MDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHK 811
            +  R +  +     DR  L    +   +  D   RE   + Q    + L +   LH+
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 99/397 (24%), Positives = 183/397 (46%), Gaps = 37/397 (9%)

Query: 249 KETLFNDSRNKIEELQQRKEA-DHKAQLARTQKLQQELEAANQSLAELRDQRQG-ERLEH 306
           KE+L  D R   EE Q+R E  D + +    Q+ +Q+ +   + LAE  +Q +  ERLE 
Sbjct: 106 KESLLQDRRQ--EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163

Query: 307 AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGL 366
               R   +++  Q  + QE+ E    E           E+    +      L E     
Sbjct: 164 RDRQRR-DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 367 AAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE-QLTQELQEARKS 425
             E QQQ+ E +D + Q+++     ++  R    +L + +E  QE+E Q  +ELQE  + 
Sbjct: 223 REEKQQQRRERQDRVFQEEE-----EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE- 276

Query: 426 AEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEE 485
            + RK    EL  E  +E+ Q +      RLR E+++   R + E E R      ++QEE
Sbjct: 277 -QLRKLERQELRRERQEEEQQQQ------RLRREQQL---RRKQEEERR------EQQEE 320

Query: 486 ELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRL-KEAEESLQQQQQEQE 544
               Q R E+   R  + L++  EE + Q    +  +   E++L +E EE  ++QQ  +E
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380

Query: 545 EALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 604
           + L++ ++    +   +E++L+  +    + Q  R+  L+    L++E ++    Q+  +
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440

Query: 605 KKGSAALKD--------LKRQLHLERKRADKLQERLQ 633
           ++    LK         LKR+   ER   ++ +++L+
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 100/451 (22%), Positives = 184/451 (40%), Gaps = 58/451 (12%)

Query: 419 LQEARKSAEKRKAMLD---ELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL-- 473
           L +A    E+++A  D    L  +  QE+ Q + E    R R  +E  G R R +R+   
Sbjct: 89  LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFE---PRDRQLEEEPGQRRRQKRQEQE 145

Query: 474 RELHEDKKRQEEELRGQIREEKARTRELETLQQTV---EELQAQVHSMDGAKGW------ 524
           REL E +++ E++ R + R+ + R  EL   +Q     EE +A+   +   KG       
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205

Query: 525 ----------FERRLKEAEESLQQQQ-------QEQEEALKQCREQHAAELKGKEEELQD 567
                      E R K  EE  QQ++       QE+EE   + RE     L+ +EE+LQ+
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE---TVLRKEEEKLQE 262

Query: 568 VRDQLEQAQEERDCHLKTI--SSLKQEVKDTVDGQRILEKKGSAALK--DLKRQLHLERK 623
              Q ++  +E +  L+ +    L++E ++    Q+ L ++     K  + +R+   ER+
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322

Query: 624 ----RADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREK 679
               R ++ +ER +  L   +     E+ +  E     R Q            +++ RE+
Sbjct: 323 EQQERREQQEERREQQLRREQEER-REQQLRREQEEERREQQLRREQEEERREQQLRREQ 381

Query: 680 E--SSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSA 737
           +        R      + Q  R  +L  E+     Q+L   QQ +   EE+ +H +    
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE-RHEQKHEQ 440

Query: 738 SMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKL-- 795
              E   ++         + R D       T+R       + L +  +E  RE   KL  
Sbjct: 441 ERREQRLKRE-------QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493

Query: 796 QNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
           +   E+Q  +   L ++ E   ++ ++  +E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEE 524


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  114 bits (285), Expect = 4e-25
 Identities = 166/842 (19%), Positives = 366/842 (43%), Gaps = 99/842 (11%)

Query: 38   LTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLM 97
            L +L+Q+V   +    + ++ +   K  ++  +L SE E LQ +L  + ++        M
Sbjct: 281  LETLQQRVKRQENLLKRCKETIQSHK--EQCTLLTSEKEALQEQLDERLQELEKIKDLHM 338

Query: 98   AEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQER 157
            AE +KL +Q+   +   +QL++   G  +A+    +  E L ++ E  A  ++       
Sbjct: 339  AEKTKLITQLRDAKNLIEQLEQD-KGMVIAETKRQMH-ETLEMKEEEIAQLRSRIKQMTT 396

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
             G+E  +    SE         A +       A  +LK EM+        EQ++ +E + 
Sbjct: 397  QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD--------EQIKTIEKTS 448

Query: 218  QAETSRLQEELAKLSEKL-----KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHK 272
            + E   LQ+EL+++ +++     K  +E   +LQ   E          +EL ++++   K
Sbjct: 449  EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE----------KELARKEQELTK 498

Query: 273  AQLARTQKLQQELEAA-NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGL 331
                R ++ Q++++ A  +S +E     Q +  + + AL  L+ Q      +++ ++  L
Sbjct: 499  KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558

Query: 332  LAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQL 391
              E    RT +  LE       QE    + Q+  LA  L+ ++ ++   +    + +   
Sbjct: 559  QQEAETYRTRILELESSLEKSLQE---NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615

Query: 392  QESLRANSRLL--EQLQEIGQ----EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKS 445
             ESL+     L  E+LQ + Q    E E+L ++ ++ +++  K K ++ +  +E + EK+
Sbjct: 616  LESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT 675

Query: 446  QHKEELGAVRLR----HEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL 501
              K ++    L        EVL  R + E EL  L +   + ++EL  ++ E+K   ++ 
Sbjct: 676  LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQ 735

Query: 502  ---------ETLQQTVEELQAQVHSMDGAKGWFERRLKEAE---ESLQQQQQEQEEALKQ 549
                      ++Q+T + L+ Q++ ++      ++ LKE +   E+L+   +  E  L+Q
Sbjct: 736  VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQ 795

Query: 550  C----------REQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT--- 596
                       +     + K  EE+L  ++ +L   + ER    K ++ ++ + KD    
Sbjct: 796  ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855

Query: 597  VDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN-----SKSRSGLEELVLS 651
            +D  +I        ++DL +QL  +    ++  + L  +  +     +K +   +++++ 
Sbjct: 856  LDAHKI-------QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908

Query: 652  EMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAEL 711
            + N   + + G    I      EIL +K S+   +  + +       +  E   E+V + 
Sbjct: 909  KENMILQMREGQKKEI------EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962

Query: 712  FQRLAETQQEKWMLEEK--VKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTD 769
             + + ET ++K + +E    K LE ++  +++   + +A +      +   +S A    +
Sbjct: 963  AKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022

Query: 770  RSGLGSV----------LRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQE 819
             +    +          L D++   ++ L +  ++LQ + E QL +     +++  L Q+
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK---EQEVAELKQK 1079

Query: 820  IV 821
            I+
Sbjct: 1080 IL 1081



 Score =  110 bits (276), Expect = 4e-24
 Identities = 195/934 (20%), Positives = 384/934 (41%), Gaps = 150/934 (16%)

Query: 3    QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
            Q + E + Q  + ++ EL+        E  +   E+T L+++    D   ++ Q+ L   
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--K 1116

Query: 63   KKAQEVEVLLSENEMLQAKLHSQEEDFR--LQNSTLMAE---------------FSKLCS 105
            +K+  V  L  +   L+A L   E D    L+ +T + E                S+L S
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176

Query: 106  QMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQ-----KNVAALQERYGK 160
            +++  ++E Q LK     +  +     ++ + L   +E  A+Q     K   AL E    
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL---SEELAIQLDICCKKTEALLEAKTN 1233

Query: 161  EAGKFSA---------VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQ 211
            E    S+         +S  Q          ++    ++E+E        + R L E+  
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELE-------AQLRQLTEEQN 1286

Query: 212  GLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK----------IE 261
             L  S Q  T +L+E+      ++K  +     L TEKE L  +  N+          I 
Sbjct: 1287 TLNISFQQATHQLEEK----ENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342

Query: 262  ELQQRKEADHKAQLARTQKLQQ---ELEAANQSLAELRDQRQG--ERLEHAAALRALQDQ 316
            +L++    +  A     ++L++   E+ + ++ L +L  Q Q      E  AA+ +L+ Q
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402

Query: 317  VSIQSADAQEQVEGLLAENNAL-RTSLAALEQI--------------QTAKTQELNMLR- 360
               +  +  +QV+ L  + + L +  ++ALEQ+              Q+  TQ  N ++ 
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE 1462

Query: 361  ----------------EQTTGLAAELQQQQAEYEDLMGQKDD-------LNSQLQESLRA 397
                            EQ   L  EL QQ   ++ L G+ +D         S L+  L++
Sbjct: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522

Query: 398  NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLR 457
             +  + +L++   +K    + L E  K+  ++K    ++  + L +K QH +ELG  +  
Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYNQQK----DIEHKELVQKLQHFQELGEEKDN 1578

Query: 458  HEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHS 517
              KE        E ++  +  + + +++EL       K++  EL+ L+  +E   A    
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA--K 1636

Query: 518  MDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGK----EEELQDVRDQLE 573
            +   K   E+++   ++ L  Q +E+EE  K+  E H +EL  K    E E+  + ++L+
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696

Query: 574  QAQEERDCHLKTISSLKQEV----KDTVDGQRILEKKGSAALKDLKRQLHLERKRADKL- 628
              +  +   L    S K       ++  D Q  ++K     +  L+R L  + K   ++ 
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756

Query: 629  QERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARS 688
            QE+ + + ++ + R   +E ++ ++      Q  D S I         + K+ S + A+ 
Sbjct: 1757 QEKEETVSSHFEMRCQYQERLI-KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH 1815

Query: 689  LSSSPQAQPPRPAELSDEEVAELFQRLAETQQEK----WMLEEKVKHLEVSSASMAEDLC 744
            +    + +  +    + + +  +F  + +T QEK     +LE+K+K L+ S     +++ 
Sbjct: 1816 V----EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD-SCLVRQKEVH 1870

Query: 745  RKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLT 804
            R    +E   + S+ +   A    D     + L       +EN  E +K   ++++ +L 
Sbjct: 1871 R----VEMEELTSKYEKLQALQQMDGRNKPTELL------EENTEEKSK--SHLVQPKLL 1918

Query: 805  KNMHL-HKDMEV-----------LSQEIVRLSKE 826
             NM   H D+E            L +EIVRL K+
Sbjct: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 161/790 (20%), Positives = 333/790 (42%), Gaps = 95/790 (12%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKV-AYLDKEFSKAQKALSKSK 63
            + + E + + ++L E+    ++L +EL     +   ++Q++ A +D++ +  Q+ +    
Sbjct: 681  VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740

Query: 64   KAQEVEVLLSE----NEMLQAKLHSQEEDFRLQN-----STLMAEFSKLCSQMEQLE--- 111
            K  EV +  +E    +++ Q +L  +E D  L+        L A+  +   +++Q     
Sbjct: 741  KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800

Query: 112  ---QENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAV 168
               Q  Q        A   Q   L   +LL L+ E   L K VA +      EA K    
Sbjct: 801  DVFQSYQSATHEQTKAYEEQLAQLQQ-KLLDLETERILLTKQVAEV------EAQKKDVC 853

Query: 169  SEGQGDPPGGPAPTVLAPMPLAEVELK-------WEMEKEEKRLLWEQLQGLESSKQAET 221
            +E                   +E+E K       +E + E+     EQ + +   K+   
Sbjct: 854  TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913

Query: 222  SRLQE----ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQR----KEADHKA 273
             +++E    E+  L++KL  K++S   L  E ET F +   K+E+++Q+    +E   K 
Sbjct: 914  LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973

Query: 274  QLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRA-LQDQVSIQSADAQEQVEGLL 332
             L +  KL++ELE     L++   Q   + LE A A  A + D VS    + +EQ+E   
Sbjct: 974  LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE--- 1030

Query: 333  AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 392
                       +L ++   +  ++  + E+      +L QQ  E +++         QLQ
Sbjct: 1031 -----------SLTEVHRRELNDVISIWEK------KLNQQAEELQEIH------EIQLQ 1067

Query: 393  ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELG 452
            E  +  + L +++   G EKE++ +E+   ++   K+   L+EL  E L++KS H   L 
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL-QEQLKQKSAHVNSLA 1126

Query: 453  AVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQ 512
                + +  +  +     + L+E +   + Q  EL+    E+K +  EL +  +T +E  
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKE-NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE-- 1183

Query: 513  AQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQL 572
             +  S+  +     + L++     ++  +E    L  C ++  A L+ K  EL ++    
Sbjct: 1184 -EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSK 1242

Query: 573  EQAQEERDCHLK---------------TISSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
              A   R  H +               T+S L+ +++   + Q  L    + + +    Q
Sbjct: 1243 TNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL----NISFQQATHQ 1298

Query: 618  LHLERKRADKLQERLQDILTNSKS---RSGLEELVLSEMNS-PSRTQTGDSSSISSFS-Y 672
            L  +  +   ++  ++ ++T  ++     G ++   SE  S  ++ +   S +I++ +  
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358

Query: 673  REILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHL 732
            +E L+EK+          +    Q      LS++E A +     +  +EK  L ++V+ L
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAA-ISSLRKQYDEEKCELLDQVQDL 1417

Query: 733  EVSSASMAED 742
                 +++++
Sbjct: 1418 SFKVDTLSKE 1427



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 169/831 (20%), Positives = 347/831 (41%), Gaps = 134/831 (16%)

Query: 3    QALSEEE--FQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
            QA SE+E    +++ +L E       + +EL++  VE++SL +++  L+ +    Q ++S
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL---QNSIS 1388

Query: 61   KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
             S+K   +  L  + +  + +L  Q +D   +  TL  E      Q++    +  + K+ 
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKK 1448

Query: 121  AAGAGVAQAGPLVDGELLRLQAENTALQKN--VAALQERYGKEAGKFSAVSEGQGDPPGG 178
            A          + + ++        A +K+  +  L+E   ++  +F  +     D    
Sbjct: 1449 AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK-- 1506

Query: 179  PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK---- 234
                  + M   E  L+ E++ +  R++  +L+   + K  E   L E L   +++    
Sbjct: 1507 ------SKMEKKESNLETELKSQTARIM--ELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558

Query: 235  ---LKKKQESFCRLQTEKETLFNDSRNKIEELQQR---KEADHKAQLARTQKLQQELEAA 288
               L +K + F  L  EK+    ++  KI  L+ +    +A+ + +    + +   +++ 
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618

Query: 289  NQSLAELRDQRQGERLEHAAALR--------ALQDQVSIQSADAQEQVE-GLLAENNALR 339
             + L  L D+ + E     A L+        A++ Q+  Q  + +EQ + G  +  + L 
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678

Query: 340  TSLAA-----------LEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK-DDL 387
            T L             L+ +++++++ L + R     +AA  +Q++A+ +  + +  ++ 
Sbjct: 1679 TKLQEREREVHILEEKLKSVESSQSETLIVPRS-AKNVAAYTEQEEADSQGCVQKTYEEK 1737

Query: 388  NSQLQESLRANSRLLEQLQEIGQEKEQLTQ--------------ELQEARKSAEKRKAML 433
             S LQ +L    +LL   Q +GQEKE+                 +L+ A     + ++M+
Sbjct: 1738 ISVLQRNLTEKEKLL---QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794

Query: 434  DELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY-----------------------E 470
              L  E L+EK++    + A  +  E     ++A+                        E
Sbjct: 1795 GHL-QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853

Query: 471  RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 530
            ++++EL     RQ+E  R ++ E  ++  +L+ LQQ           MDG     E  L+
Sbjct: 1854 QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ-----------MDGRNKPTE-LLE 1901

Query: 531  EAEESLQQQQQEQEEALKQCREQH---AAELKGKEEELQDVRDQLEQAQEE----RDCHL 583
            E  E   +    Q + L     QH     +L G E E Q +  ++ + Q++    R  H 
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961

Query: 584  KTISSLKQEV-----KDTVDGQRILEKKGSAALKDLKRQLHLE-RKRADKLQERLQDILT 637
            + +  LK+E      +     Q  LE K ++ LK L R+ + +  ++  +L+  +++  T
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE--T 2019

Query: 638  NSKSRSGLEELVLSEMNSPSR-----TQTGDSSSISSFSYREIL--REKESSAVPARSLS 690
             +K++    EL+ S     ++      +  D    ++  Y EIL  RE+E +A      +
Sbjct: 2020 INKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT 2079

Query: 691  SSPQAQPPRPAELSDEE--------VAELFQRLAETQQEKWMLEEKVKHLE 733
               + Q     +L  EE        + EL  +LA  Q+   + + K+K  E
Sbjct: 2080 QLEELQKKYQQKLEQEENPGNDNVTIMELQTQLA--QKTTLISDSKLKEQE 2128



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 141/676 (20%), Positives = 288/676 (42%), Gaps = 105/676 (15%)

Query: 190 AEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEK 249
           +E+   ++M + EK+    +LQG+ S  Q ++ R    +A+L E+L+  Q++   LQ E 
Sbjct: 158 SELVTAYQMLQREKK----KLQGILSQSQDKSLR---RIAELREELQMDQQAKKHLQEEF 210

Query: 250 ETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA 309
           +    +    I  LQ            +   L+Q L     ++  L+             
Sbjct: 211 DASLEEKDQYISVLQ-----------TQVSLLKQRLRNGPMNVDVLK------------P 247

Query: 310 LRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAE 369
           L  L+ Q  + + +   + +G     +   TS+  LE +Q    ++ N+L+         
Sbjct: 248 LPQLEPQAEVFTKEENPESDGEPVVEDG--TSVKTLETLQQRVKRQENLLKR----CKET 301

Query: 370 LQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ-EKEQLTQELQEARKSAEK 428
           +Q  + +   L  +K+ L  QL E L+     LE+++++   EK +L  +L++A      
Sbjct: 302 IQSHKEQCTLLTSEKEALQEQLDERLQE----LEKIKDLHMAEKTKLITQLRDA------ 351

Query: 429 RKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELR 488
            K ++++L  +     ++ K ++       E+E+  +R+R ++   +  E ++++E+  R
Sbjct: 352 -KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 489 GQIRE-EKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQ-------- 539
               E EKA    L T Q+T E  +     MD      E+  +E   SLQQ+        
Sbjct: 411 AAFEELEKA----LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466

Query: 540 ----QQEQEEALKQCREQHAAELKGKEEEL--------QDVRDQLEQAQEERDCHLKTIS 587
               ++  EE + + ++ H  EL  KE+EL        ++ ++Q++ A E+       IS
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526

Query: 588 SLKQEVKDTVDGQRILEKK-----GSAALKDLKRQLHLERKRADKLQERLQDILTNSKSR 642
             K++ +     +  L+KK         L+DL+++    R R  +L+  L+  L  +K++
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586

Query: 643 S-GLEELVLSEMNSPSRTQT----GDSSSISSFSYREILREKESSAVPARSLSSS----- 692
           S  L   + +E N  ++  T       + + S  +++     E   V  +   +      
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646

Query: 693 PQAQPPRPAELSDEEVAELFQRLAETQQEKWM--LEEKVKHLEVSSASMAEDLCRKSAII 750
            + +  +   L D+E+  +FQ   E   EK +  L+ K   LE  S+ ++E L  +  + 
Sbjct: 647 EKCEQEKETLLKDKEI--IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLE 704

Query: 751 ETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLH 810
           E        ++SV    TD+     + ++L    DE      +++ ++++E         
Sbjct: 705 E--------ELSVLKDQTDK-----MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751

Query: 811 KDMEVLSQEIVRLSKE 826
           K ++    ++  L KE
Sbjct: 752 KALKDQINQLELLLKE 767



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 140/615 (22%), Positives = 251/615 (40%), Gaps = 86/615 (13%)

Query: 252 LFNDSRNKI-EELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAAL 310
           +F   + KI EE QQ ++A   AQ +        + +   S  E  D+    R       
Sbjct: 1   MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60

Query: 311 RALQDQVSIQSADAQEQVEGLLAE--NNALRTSLAALEQIQTAKTQELNMLR-EQTTGLA 367
            A + Q+ + S      VE L       +L  S +    ++T+  + LN L  + +T   
Sbjct: 61  FAQKLQLRVPS------VESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASF 114

Query: 368 AELQQQQAEYEDLMGQKDDLNS-QLQESLRANSR-----------LLEQLQEIGQEKEQL 415
                  +E EDL+G  D LN  QL + LR   R           L+   Q + +EK++L
Sbjct: 115 DPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL 174

Query: 416 TQELQEARKSAEKRKAML-DELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 474
              L +++  + +R A L +EL M+  Q+  +H +E     L  + + + V         
Sbjct: 175 QGILSQSQDKSLRRIAELREELQMD--QQAKKHLQEEFDASLEEKDQYISVL-------- 224

Query: 475 ELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM------DGAKGWFERR 528
                 + Q   L+ ++R        L+ L Q   E QA+V +       DG     +  
Sbjct: 225 ------QTQVSLLKQRLRNGPMNVDVLKPLPQL--EPQAEVFTKEENPESDGEPVVEDGT 276

Query: 529 LKEAEESLQQQQQEQEEALKQCRE------QHAAELKGKEEELQDVRDQ-LEQAQEERDC 581
             +  E+LQQ+ + QE  LK+C+E      +    L  ++E LQ+  D+ L++ ++ +D 
Sbjct: 277 SVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL 336

Query: 582 HLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH--LERKRAD--KLQERLQDILT 637
           H+   + L  +++D  +    LE+     + + KRQ+H  LE K  +  +L+ R++ + T
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396

Query: 638 NSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQP 697
                   EEL         R Q   S   +     + L   + +    R L +    Q 
Sbjct: 397 QG------EEL---------REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI 441

Query: 698 PRPAELSDEEVAELFQRLAETQQE-----KWMLEEKVKHL----EVSSASMAEDLCRKSA 748
               + S+EE   L Q L+  +QE     K   EE++  L    E   A   ++L +K  
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK-- 499

Query: 749 IIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMH 808
            ++T   + +  + VA   +    L  + ++  +     L E+  + + +L E   K   
Sbjct: 500 -LQTREREFQEQMKVALEKSQSEYL-KISQEKEQQESLALEELELQKKAILTESENKLRD 557

Query: 809 LHKDMEVLSQEIVRL 823
           L ++ E     I+ L
Sbjct: 558 LQQEAETYRTRILEL 572



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 119/535 (22%), Positives = 216/535 (40%), Gaps = 72/535 (13%)

Query: 6    SEEEFQRMQAQLLELRTNNYQLSDELRKNGVE--LTSLRQKVAYLDKEFSKAQKALSKSK 63
            +E++   ++ QLL    +  +  +E  K G E  L+ L  K+   ++E    ++ L KS 
Sbjct: 1644 AEQKIAAIKKQLL----SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL-KSV 1698

Query: 64   KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLC------SQMEQLEQENQQL 117
            ++ + E L+          ++++E+   Q         K+       ++ E+L Q   Q 
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758

Query: 118  KEGAAGAGVAQAGPLVDG--ELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDP 175
            KE    +         +   +L   +A+    Q  +  LQE   ++  K+S +     + 
Sbjct: 1759 KEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818

Query: 176  PGGPAPTVLAPMPLAEVELKWEMEKEEKRL----LWEQLQGLESS--KQAETSRLQ-EEL 228
             GG    + A   L  V    +   +EK L    L ++++ L+S   +Q E  R++ EEL
Sbjct: 1819 EGGKN-NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877

Query: 229  AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEEL-QQRKEADHKAQLARTQKLQQELEA 287
                EKL+  Q+              D RNK  EL ++  E   K+ L +  KL   +EA
Sbjct: 1878 TSKYEKLQALQQM-------------DGRNKPTELLEENTEEKSKSHLVQP-KLLSNMEA 1923

Query: 288  ANQSL------AELRDQRQGE------------RLEHAAALRALQDQVSIQSADA--QEQ 327
             +  L      AE   Q+ G+            R EH   L  L+ +   +  +   QEQ
Sbjct: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983

Query: 328  VEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDL 387
             +  L  N+ L+  +         K QEL M  ++T   A     Q+ E E L   +++ 
Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKA-----QEVEAELLESHQEET 2038

Query: 388  NSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 447
            N  L++    +  L        +   +  +E+ +AR+     K    +  +E LQ+K Q 
Sbjct: 2039 NQLLKKIAEKDDDL--------KRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090

Query: 448  KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELE 502
            K E           ++ ++ +  ++   L  D K +E+E R QI   + R ++ E
Sbjct: 2091 KLEQEENPGNDNVTIMELQTQLAQK-TTLISDSKLKEQEFREQIHNLEDRLKKYE 2144


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score =  114 bits (285), Expect = 4e-25
 Identities = 194/921 (21%), Positives = 391/921 (42%), Gaps = 146/921 (15%)

Query: 2    AQALSEEEFQRMQAQLLELRTN-----NYQLSDELRKNGV--ELTSLRQKVAYLDKEFSK 54
            +QAL E+    +QAQL  L T          S + R++ +  E+ +L+Q    L++  + 
Sbjct: 429  SQALKEKA--ELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTD 486

Query: 55   AQKAL-----SKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNST---LMAEFSKLCSQ 106
             Q  L     S +    +++V   + + L AK+   +     +++T   L  + + L SQ
Sbjct: 487  LQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQ 546

Query: 107  MEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFS 166
            ++Q++ E   L      +           E+  LQ+     Q+ +A  QE   +  G+ +
Sbjct: 547  LQQVQLERTTLTSKLKAS---------QAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597

Query: 167  AVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQE 226
             +  GQ    G     +L  + L  V L  ++ + + R + E+             R+  
Sbjct: 598  HIQVGQMTQAG-----LLEHLKLENVSLSQQLTETQHRSMKEK------------GRIAA 640

Query: 227  ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ-QRKEADHKAQLARTQKLQQEL 285
            +L  +   +  ++ +F ++Q  K  +  D + ++EE + +R+     A  A +  L+Q+L
Sbjct: 641  QLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAAS--LEQQL 698

Query: 286  EAANQSLAELRDQRQGERLEHAAALRALQ-DQVSIQSADAQEQVEGLLAENNALRTSLAA 344
            E    +L +   Q +  + EH   ++ L   Q ++QS +  + ++ L    + L+  L  
Sbjct: 699  EQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSRE--QSLDALQTHYDELQARLGE 756

Query: 345  LEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQ 404
            L+    ++   + +L+ +   L A LQ  ++  E+L    D    +L+E     S  LE+
Sbjct: 757  LQGEAASREDTICLLQNEKIILEAALQAAKSGKEEL----DRGARRLEEGTEETSETLEK 812

Query: 405  LQE-----------IGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGA 453
            L+E           + QE   L +++Q+ ++   ++K M++    +    K Q   EL A
Sbjct: 813  LREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATS-KDQLISELKA 871

Query: 454  VRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRE--------LETLQ 505
             R R + E+  +R    +EL ++H +K+  E EL  ++  E A+ R+        L++ Q
Sbjct: 872  TRKRLDSELKELR----QELMQVHGEKRTAEAEL-SRLHREVAQVRQHMADLEGHLQSAQ 926

Query: 506  QTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQE-QEEALKQCREQH------AAEL 558
            +  +E++  + S+   K      + EA E+L++Q +E Q+EA K   EQ        ++L
Sbjct: 927  KERDEMETHLQSLQFDKEQMVA-VTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDL 985

Query: 559  KGKEEELQDVRDQLEQA--------------QEERDCHL-----------------KTIS 587
               ++E++      E A              +E  D  L                 + I 
Sbjct: 986  TSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQ 1045

Query: 588  SLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEE 647
            +L+ E++     + +LEK+    +    ++L   R++  +L++ LQ+     K    LEE
Sbjct: 1046 ALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEE 1105

Query: 648  ---LVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP-RPAEL 703
                +  E+       TG   S ++      + E   +   A  +  + Q Q   +  E 
Sbjct: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE 1165

Query: 704  SDEEVAELFQRL-AETQQEKW---MLEEKV-----------KHLEVSSASMAE---DLCR 745
             D ++  L Q L A  ++EK     L+E+V           +H + +S  ++E   +L  
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225

Query: 746  KSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTK 805
            K  +++    ++  D+ +  G   +  +     +L +      R   + LQ  L+EQL+K
Sbjct: 1226 KEHLVQKLQAEAD-DLQIREGKHSQE-IAQFQAELAE-----ARAQLQLLQKQLDEQLSK 1278

Query: 806  NMHLHKDMEVLSQEIVRLSKE 826
                +++ME L  E+ +  +E
Sbjct: 1279 QPVGNQEMENLKWEVDQKERE 1299



 Score =  111 bits (277), Expect = 3e-24
 Identities = 198/854 (23%), Positives = 366/854 (42%), Gaps = 137/854 (16%)

Query: 8    EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
            E  QRM      L     Q+   L +   +L +L+Q+   L K+ +  Q+AL    + Q 
Sbjct: 682  ERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS--REQS 739

Query: 68   VEVLLSENEMLQAKLH-------SQEEDF-RLQNSTLMAEFSKLCSQM--EQLEQENQQL 117
            ++ L +  + LQA+L        S+E+    LQN  ++ E +   ++   E+L++  ++L
Sbjct: 740  LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRL 799

Query: 118  KEGAAGAG-----VAQAGPLVDGELLRLQAENTALQKNVAALQERYGK-----EAGKFSA 167
            +EG          + +   +  G++  LQ E  AL+K +  ++E++ +     EA +  A
Sbjct: 800  EEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDA 859

Query: 168  VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 227
             S+ Q          +++ +      L  E+++  + L+  Q+ G + + +AE SRL  E
Sbjct: 860  TSKDQ----------LISELKATRKRLDSELKELRQELM--QVHGEKRTAEAELSRLHRE 907

Query: 228  LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEA 287
            +A++ + +   +      Q E++ +       ++ LQ  KE    A     + L++++E 
Sbjct: 908  VAQVRQHMADLEGHLQSAQKERDEM----ETHLQSLQFDKE-QMVAVTEANEALKKQIEE 962

Query: 288  ANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ 347
              Q   +   +++ +     + L + Q ++  +   A E   G+L+    L+ +LAA E 
Sbjct: 963  LQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHK-AYENAVGILSRR--LQEALAAKE- 1018

Query: 348  IQTAKTQELNMLREQ------TTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRL 401
               A   EL  LR Q      +  L   +Q  +AE + +   K  L  +LQE +   S+ 
Sbjct: 1019 ---AADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQE 1075

Query: 402  LEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKE 461
            LE+ +E   +  +L  ELQE+R   +K K +          E+S  K    A+ L HEK 
Sbjct: 1076 LEESRE---KVLELEDELQESRGFRKKIKRL----------EESNKKL---ALELEHEKG 1119

Query: 462  VLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 521
             L    +    LRE               I E     RE + +Q     L  QV ++   
Sbjct: 1120 KLTGLGQSNAALRE------------HNSILETALAKREADLVQ-----LNLQVQAVLQR 1162

Query: 522  KGWFERRLKEAEESLQQQQQEQEEALKQCREQHAA----------ELKGKEEELQDVRDQ 571
            K   +R++K   ++LQ   ++++E +   +EQ AA            K    EL +V+ +
Sbjct: 1163 KEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKE 1222

Query: 572  LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQER 631
            L QA+E           L Q+++   D  +I E K S  +   + +L   R +   LQ++
Sbjct: 1223 L-QAKEH----------LVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQ 1271

Query: 632  LQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSS 691
            L + L+     +   E +  E++   R        I S   +  L E++      + L  
Sbjct: 1272 LDEQLSKQPVGNQEMENLKWEVDQKER-------EIQSLKQQLDLTEQQGR----KELEG 1320

Query: 692  SPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAE-------DLC 744
              Q      +EL   E+A+  + L+ TQ++K+ML+ KV  L+ +  ++ +       DL 
Sbjct: 1321 LQQLLQNVKSEL---EMAQ--EDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLR 1375

Query: 745  RKSAII--ETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKP----GDENLREMNKKLQNM 798
            R +A    E     S  + +      D     S+L +L++P      E L+ +N  LQ +
Sbjct: 1376 RGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQL 1435

Query: 799  LEE--QLTKNMHLH 810
             +E   L + M  H
Sbjct: 1436 KQEMDSLQRQMEEH 1449



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 152/693 (21%), Positives = 270/693 (38%), Gaps = 110/693 (15%)

Query: 190  AEVELKWEMEKEEKRLLWEQLQGLE---SSKQAETSRLQEELAKLSEKLKKKQESFCRLQ 246
            AE + +     +EK  L  QL+ L    S    E + LQ +LA LS KL+ + E     Q
Sbjct: 401  AETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQ 460

Query: 247  TEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEH 306
              +++L +       E+   K++    + A T  LQ  LEA N SLA   +  Q      
Sbjct: 461  QRQDSLSS-------EVDTLKQSCWDLERAMTD-LQNMLEAKNASLASSNNDLQV----- 507

Query: 307  AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGL 366
                             A+EQ + L+A+   ++ S+ +       K   ++ LR+Q T L
Sbjct: 508  -----------------AEEQYQRLMAKVEDMQRSMLS-------KDNTVHDLRQQMTAL 543

Query: 367  AAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSA 426
             ++LQQ Q E            + L   L+A+   +  LQ + Q  +Q     QEAR   
Sbjct: 544  QSQLQQVQLE-----------RTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRL 592

Query: 427  EKRKA-----------MLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRE 475
            +   A           +L+ L +E +    Q    L   + R  KE    + R   +L+ 
Sbjct: 593  QGEMAHIQVGQMTQAGLLEHLKLENVSLSQQ----LTETQHRSMKE----KGRIAAQLQG 644

Query: 476  LHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQ---VHSMDGAKGWFERRLKEA 532
            +  D   QE     QI+E  A+T   E LQ+ +EE + +   +  M  +    E++L++ 
Sbjct: 645  IEADMLDQEAAFM-QIQE--AKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQV 701

Query: 533  EESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQE 592
            + +L Q+ Q Q EAL+Q       +L   +E LQ     L+  Q   D     +  L+ E
Sbjct: 702  KLTLLQRDQ-QLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGE 760

Query: 593  V---KDTV---DGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 646
                +DT+     ++I+ +    A K  K +L    +R ++  E   + L   +    ++
Sbjct: 761  AASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIK 820

Query: 647  ELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQ--AQPPRPAELS 704
               +  +   +         I      + L++K       R  +S  Q  ++     +  
Sbjct: 821  SGQVEHLQQETAALKKQMQKIK----EQFLQQKVMVEAYRRDATSKDQLISELKATRKRL 876

Query: 705  DEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLC----------RKSAIIETYV 754
            D E+ EL Q L +   EK   E ++  L    A + + +           ++   +ET++
Sbjct: 877  DSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHL 936

Query: 755  MDSRIDVSVAAGHTDRS--------GLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKN 806
               + D       T+ +         L    R  +    + +R +   L +  +E  TK+
Sbjct: 937  QSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKH 996

Query: 807  MHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGE 839
                  + +LS+   RL +        D E G+
Sbjct: 997  KAYENAVGILSR---RLQEALAAKEAADAELGQ 1026



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 24/121 (19%), Positives = 53/121 (43%), Gaps = 4/121 (3%)

Query: 705 DEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVA 764
           +   AE  + + +  +EK  LE +++ L + ++   ++     A  +   + +++   V 
Sbjct: 397 ESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQA--QLAALSTKLQAQVE 454

Query: 765 AGHTDRSGLGSVLR--DLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVR 822
             H+ +    S+    D +K    +L      LQNMLE +       + D++V  ++  R
Sbjct: 455 CSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQR 514

Query: 823 L 823
           L
Sbjct: 515 L 515


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score =  114 bits (284), Expect = 5e-25
 Identities = 205/895 (22%), Positives = 382/895 (42%), Gaps = 189/895 (21%)

Query: 29   DELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQE-- 86
            +ELR++ + L   +   A L+++ + A+   ++  K  E+E    EN  L++KLH  E  
Sbjct: 350  EELREDNIILIETK---AMLEEQLTAAR---ARGDKVHELE---KENLQLKSKLHDLELD 400

Query: 87   --------EDFRLQNSTL-------MAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGP 131
                    E+   +N  L       M E + L  ++EQL  +N  L + +  + V +   
Sbjct: 401  RDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQL-SKNADLSDASRKSFVFELNE 459

Query: 132  LVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAE 191
                 +L+L+ EN +LQ  +  L++                            A + L E
Sbjct: 460  CASSRILKLEKENQSLQSTIQGLRD----------------------------ASLVLEE 491

Query: 192  VELK-WEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKE 250
              LK  E+EKE  +L  ++++ L++  + E  +  ++L  LSE+L +++E   +LQ++ E
Sbjct: 492  SGLKCGELEKENHQLS-KKIEKLQTQLERE-KQSNQDLETLSEELIREKE---QLQSDME 546

Query: 251  TLFNDSRNKIEELQQRKEADHKAQL-----------ARTQKLQQELEAANQSLAEL---- 295
            TL  D   +I++L+Q K+  ++A             AR + +++E +A +Q++ E     
Sbjct: 547  TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKL 606

Query: 296  -----------RDQRQ----GERLEH-AAALRALQDQ--------VSIQSAD-----AQE 326
                       RD  Q    GER E     L+ LQ++         S+++A       + 
Sbjct: 607  SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEH 666

Query: 327  QVEGLLAENNALRTSLAALEQIQ-------------TAKTQELNMLREQTTGLAAELQQQ 373
            + +GL  EN  LR SL  L+ +               A+  EL  L E     + +L Q 
Sbjct: 667  ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQM 726

Query: 374  QAEYEDLMGQKDDL--NSQLQESLRANSRLLE-QLQEIGQEKEQLTQELQEARKSAEKRK 430
            + E + L  +K++L  N  L ++L   S  LE   Q +  E  +L Q L+ +    +  +
Sbjct: 727  ERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLE 786

Query: 431  AMLDELAMETLQEKSQHKEELGAVRLRH------EKEVLGVRARYERELRELHEDKKRQE 484
            + L EL      E+   + +L A+RL +      EK+    R   E+E+ +L +DKK  E
Sbjct: 787  SELGELE----AERQALRRDLEALRLANAQLEGAEKD----RKALEQEVAQLEKDKKLLE 838

Query: 485  EELRGQIREEKAR-------TRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEE--- 534
            +E +   ++ + +       T +L  +++    L  ++     A G    +LKE E+   
Sbjct: 839  KEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAG----KLKELEKDNR 894

Query: 535  SLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVK 594
             L +Q       L   RE    E K K ++L    D+L Q  E+   + + +  L+++  
Sbjct: 895  DLTKQVTVHARTLTTLREDLVLE-KLKSQQLSSELDKLSQELEKVGLNRELL--LQEDDS 951

Query: 595  DTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 654
             +    +ILE +  +A   LK  L ++ ++   L+ ++++  + ++      +++  E  
Sbjct: 952  GSDTKYKILEGRNESA---LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECE 1008

Query: 655  SPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQ---AQPPRPAELSDE----- 706
            +  + Q       +SF +            PA   ++S Q   A  P   E + E     
Sbjct: 1009 TLRQNQGEGQHLQNSFKH------------PAGKTAASHQGKEAWGPGHKEATMELLRVK 1056

Query: 707  -EVAELFQRLAETQQEKWMLEEKVKHLE---VSSASMAEDLCRKSAIIETYVMDSRIDVS 762
                EL +  A  Q EK +L+E+++HLE   V+ +S    L ++SA ++ +  ++ +   
Sbjct: 1057 DRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEH--NTTLQTQ 1114

Query: 763  VAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLS 817
             A    + S L S            L      LQN    + T+N  L +  E L+
Sbjct: 1115 TAKLQVENSTLSS--------QSAALTAQYTLLQNHHTAKETENESLQRQQEQLT 1161



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 154/699 (22%), Positives = 293/699 (41%), Gaps = 106/699 (15%)

Query: 183 VLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL------- 235
           VL    + +  ++   +    R   ++L  L   K     RL+ EL +  EKL       
Sbjct: 288 VLELQKVKQENIQLAADARSARAYRDELDSLRE-KANRVERLELELTRCKEKLHDVDFYK 346

Query: 236 ----KKKQESFCRLQT-----EKETLFNDSRNKIEELQ----QRKEADHKAQLART--QK 280
               + ++++   ++T     E+ T      +K+ EL+    Q K   H  +L R   +K
Sbjct: 347 ARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKK 406

Query: 281 LQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD-----------AQEQVE 329
             +EL   N  L   + Q   E       L  L     +  A            A  ++ 
Sbjct: 407 RIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRIL 466

Query: 330 GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNS 389
            L  EN +L++++  L        ++ +++ E++     EL++   E   L  + + L +
Sbjct: 467 KLEKENQSLQSTIQGL--------RDASLVLEESGLKCGELEK---ENHQLSKKIEKLQT 515

Query: 390 QLQESLRANSRLLEQLQEIGQEKEQLTQELQEAR-------KSAEKRKAMLDELAMETLQ 442
           QL+   ++N  L    +E+ +EKEQL  +++  +       K  E+ K  L+  AM +L+
Sbjct: 516 QLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNR-AMWSLR 574

Query: 443 EKSQHKEELGAVRLRHEKEVL--------GVRARYERELRELHEDKKRQEEELRGQIREE 494
           E+SQ   E     +  E + L        G  ++ E E R+LH D ++ +E  +G+ R E
Sbjct: 575 ERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKE--KGE-RAE 631

Query: 495 KARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQH 554
           K   REL+ LQ+    L  +V S++ A    E  L+   + LQ + +   ++L       
Sbjct: 632 KLE-RELQRLQEENGRLARKVTSLETATEKVE-ALEHESQGLQLENRTLRKSL------- 682

Query: 555 AAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDL 614
                   + LQ+V  QLE  + +     K + +   E++  V+  R    K        
Sbjct: 683 --------DTLQNVSLQLEGLERDN----KQLDAENLELRRLVETMRFTSTK-------- 722

Query: 615 KRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYRE 674
             Q+  E ++ ++ +E L+  +   K+     E +     S S        S+ S S++ 
Sbjct: 723 LAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKT 782

Query: 675 ILREKESSAVPARSLSSSPQAQPPRPA----ELSDEEVAELFQRLAETQQEKWMLEEKVK 730
              E E   + A   +     +  R A    E ++++   L Q +A+ +++K +LE++ K
Sbjct: 783 QTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAK 842

Query: 731 HL----EVSSASMAEDLCRKSAI-IETYVMDSRI-DVSVAAGHTDRSGLGSVLRDLVKPG 784
            L    E+  A + +   + SA+  E+  +D  +     AAG      L    RDL K  
Sbjct: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKE--LEKDNRDLTKQV 900

Query: 785 DENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
             + R +    ++++ E+L K+  L  +++ LSQE+ ++
Sbjct: 901 TVHARTLTTLREDLVLEKL-KSQQLSSELDKLSQELEKV 938



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 146/620 (23%), Positives = 251/620 (40%), Gaps = 83/620 (13%)

Query: 16   QLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK-SKKAQEVE-VLLS 73
            +L EL  +N  L+ ++  +   LT+LR+ +     E  K+Q+  S+  K +QE+E V L+
Sbjct: 885  KLKELEKDNRDLTKQVTVHARTLTTLREDLVL---EKLKSQQLSSELDKLSQELEKVGLN 941

Query: 74   ENEMLQAKLHSQEEDFR-LQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVAQAGPL 132
               +LQ      +  ++ L+     A  + L  + E++     Q++E A+          
Sbjct: 942  RELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKAS------LNRQ 995

Query: 133  VDGELLRLQAENTALQKNVAA---LQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPL 189
            ++ EL  L+ E   L++N      LQ  +   AGK +A    QG    GP         L
Sbjct: 996  LESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAA--SHQGKEAWGPGHKEATMELL 1053

Query: 190  AEVELKWEMEKE------EKRLLWEQLQGLESSKQAETSR---LQEELAKLSEKLKKKQE 240
               +   E+E+       EK+LL EQLQ LE+     +S+   LQ++ A L E     Q 
Sbjct: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113

Query: 241  SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300
               +LQ E  TL + S            A   AQ    Q      E  N+SL     QRQ
Sbjct: 1114 QTAKLQVENSTLSSQS------------AALTAQYTLLQNHHTAKETENESL-----QRQ 1156

Query: 301  GERLEHAAALRALQDQVSIQSADAQE--QVEGLLAENNALRTSLAALEQIQTA------- 351
             E+L  AA    LQD   + +   ++  + E L+ +++ L+T    LE            
Sbjct: 1157 QEQLT-AAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGD 1215

Query: 352  ---KTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI 408
               +  EL    +  T     LQQ+Q      MG+   L  +L      + +L  + +E+
Sbjct: 1216 MLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEEL 1275

Query: 409  GQEKEQLTQELQEARKSAEKRKAMLDELAME------TLQEKSQHKEELGAVRLRHEKE- 461
                ++L   L  A+    + +A  DEL  +      +L +   H E L  ++   E+E 
Sbjct: 1276 HAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEEN 1335

Query: 462  ------VLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 515
                  +  +  + +  L +  E+K++  EE +  I +  A  R  E L++ + + Q + 
Sbjct: 1336 HHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD-QYKF 1394

Query: 516  HSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKE----EELQDVRDQ 571
            +     K       K   + ++ +++   E LK   +    +L+  +       Q +R Q
Sbjct: 1395 YDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQ 1454

Query: 572  LE---------QAQEERDCH 582
             E            EERD H
Sbjct: 1455 AENPDTPALGSNCAEERDAH 1474



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 142/631 (22%), Positives = 244/631 (38%), Gaps = 59/631 (9%)

Query: 8    EEFQRMQAQLLELRTNNYQLS---DELRKNGVELTSLRQKVAYLDKEFSKA--------Q 56
            E  +    +L ++   N QL    +ELRKN   L +L +K   L+  +           Q
Sbjct: 714  ETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQ 773

Query: 57   KALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMA---EFSKLCSQMEQLEQE 113
               S S K Q +E  L E E  +  L    E  RL N+ L     +   L  ++ QLE++
Sbjct: 774  SLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKD 833

Query: 114  NQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQG 173
             + L++ A    + Q   L D  L    A+ +A++K   AL +   +       + E + 
Sbjct: 834  KKLLEKEAKR--LWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEK 891

Query: 174  DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 233
            D         +    L  +     +EK + + L  +L  L  S++ E   L  EL  L E
Sbjct: 892  DNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKL--SQELEKVGLNRELL-LQE 948

Query: 234  KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 293
                    +  L+   E+    +    EE     EA  + + +  ++L+ EL+   +   
Sbjct: 949  DDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECE 1008

Query: 294  ELR-DQRQGERLEHAAALRALQDQVSIQSADA------QEQVEGLLAENNALRTSLAALE 346
             LR +Q +G+ L+++    A +   S Q  +A      +  +E L  ++ A+      LE
Sbjct: 1009 TLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIE-----LE 1063

Query: 347  QIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ 406
            +   A   E  +L+EQ          Q  E +++      L  Q Q +         Q Q
Sbjct: 1064 RNNAALQAEKQLLKEQL---------QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQ 1114

Query: 407  EIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVR 466
                + E  T   Q A  +A+         A ET  E  Q ++E    +L    E L   
Sbjct: 1115 TAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQE----QLTAAYEAL--- 1167

Query: 467  ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFE 526
             +    L  LHE +  + E L  Q    K   R LE   + + E    +          E
Sbjct: 1168 LQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEERE 1227

Query: 527  RRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTI 586
            + L    E+LQQ+Q+    A+ + +      L+G+ + +  +  QL+   EE   H K  
Sbjct: 1228 KVLTTEREALQQEQRTNALAMGENQR-----LRGELDRVNFLHHQLKGEYEELHAHTK-- 1280

Query: 587  SSLKQEVKDTVDGQRILEKKGSAALKDLKRQ 617
                 E+K +++  ++   +  A   +LK Q
Sbjct: 1281 -----ELKTSLNNAQLELNRWQARFDELKEQ 1306



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 126/550 (22%), Positives = 211/550 (38%), Gaps = 83/550 (15%)

Query: 4    ALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVA---YLDKEFSKAQKALS 60
            A+ EE+   ++AQ+ E  + N QL  EL+    E  +LRQ      +L   F       +
Sbjct: 973  AMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTA 1032

Query: 61   KSKKAQEV-EVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQEN----- 114
             S + +E       E  M   ++  +  +    N+ L AE   L  Q++ LE +N     
Sbjct: 1033 ASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSS 1092

Query: 115  QQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGD 174
            Q L      A + +    +  +  +LQ EN+ L    AAL  +Y                
Sbjct: 1093 QILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQY---------------- 1136

Query: 175  PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 234
                   T+L     A+     E E E  +   EQL     +   +     E L  L E+
Sbjct: 1137 -------TLLQNHHTAK-----ETENESLQRQQEQLTAAYEALLQD----HEHLGTLHER 1180

Query: 235  LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAE 294
               + E+  R  +  +TL  +   + +EL +R    H   L R    + ELE   + L  
Sbjct: 1181 QSAEYEALIRQHSCLKTLHRNLELEHKELGER----HGDMLKR----KAELEEREKVLTT 1232

Query: 295  LRDQRQGERLEHAAA------LRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQI 348
             R+  Q E+  +A A      LR   D+V+      + + E L A    L+TSL   +  
Sbjct: 1233 EREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLE 1292

Query: 349  QTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEI 408
                    + L+EQ   +   L +     E L   K +L  +       N  LL Q+Q +
Sbjct: 1293 LNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE-------NHHLLSQIQLL 1345

Query: 409  GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRAR 468
             Q+ + L ++  E ++                 +E+ Q+ ++L A  LR  KE L  +  
Sbjct: 1346 SQQNQMLLEQNMENKEQYH--------------EEQKQYIDKLNA--LRRHKEKLEEKIM 1389

Query: 469  YERELRELHEDKKRQ---EEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWF 525
             + +  +    KK      + L   I+ +K  +R  E L+ TV+    Q+ S D A    
Sbjct: 1390 DQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSR--ERLKSTVDSPPWQLESSDPASPAA 1447

Query: 526  ERRLKEAEES 535
             + L+   E+
Sbjct: 1448 SQPLRSQAEN 1457



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 108/508 (21%), Positives = 201/508 (39%), Gaps = 74/508 (14%)

Query: 268 EADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAA---LRALQDQVSIQSADA 324
           EA  ++ +   ++L  + +   + + +L  +R   + +H  +     +     S  S+ +
Sbjct: 186 EALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLS 245

Query: 325 QEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK 384
            E  + L  E    +  L  + Q    KT++L   R +   L  ELQ+ + E   L    
Sbjct: 246 SEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAAD- 304

Query: 385 DDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQEL---QEARKSAEKRKAMLDELAMET- 440
                    S RA    L+ L+E     E+L  EL   +E     +  KA ++EL  +  
Sbjct: 305 -------ARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNI 357

Query: 441 --LQEKSQHKEELGAVRLRH------EKEVLGVRARYERELRELHEDKKRQEEELRGQIR 492
             ++ K+  +E+L A R R       EKE L ++++      +   DKKR EE L   + 
Sbjct: 358 ILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMV 417

Query: 493 EEKARTRELET---LQQTVEELQAQVHSMDGAKGWFERRLKEAEES----LQQQQQEQEE 545
            E A+ + +     L   +E+L       D ++  F   L E   S    L+++ Q  + 
Sbjct: 418 LEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQS 477

Query: 546 ALKQCR----------------EQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTIS-S 588
            ++  R                E+   +L  K E+LQ   ++ +Q+ ++    L+T+S  
Sbjct: 478 TIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQD----LETLSEE 533

Query: 589 LKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEEL 648
           L +E +        L+   +  +KDL+++     +    L+ER Q    +S++R    E 
Sbjct: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ---VSSEARMKDVEK 590

Query: 649 VLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEV 708
               ++       G  S +  F  R++ R+ E                    A+   E  
Sbjct: 591 ENKALHQTVTEANGKLSQL-EFEKRQLHRDLEQ-------------------AKEKGERA 630

Query: 709 AELFQRLAETQQEKWMLEEKVKHLEVSS 736
            +L + L   Q+E   L  KV  LE ++
Sbjct: 631 EKLERELQRLQEENGRLARKVTSLETAT 658



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 65/289 (22%), Positives = 120/289 (41%), Gaps = 35/289 (12%)

Query: 556 AELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 615
           A L+   +EL+D  +QL   + E D  +  +  +KQE     + Q   + + + A +D  
Sbjct: 261 ARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQE-----NIQLAADARSARAYRDEL 315

Query: 616 RQLHLERKRADKLQ-------ERLQDILTNSKSRSGLEE--LVLSEMNSPSRTQTGDSSS 666
             L  +  R ++L+       E+L D+         L E  ++L E  +    Q   ++ 
Sbjct: 316 DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQL-TAAR 374

Query: 667 ISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEE-VAELFQR--LAETQQEKW 723
                  E+ +E          L         R  EL +E  V E+ Q+  + E+    W
Sbjct: 375 ARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGW 434

Query: 724 MLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRD---- 779
            LE+  K+ ++S AS      RKS + E     S   + +   +         LRD    
Sbjct: 435 ELEQLSKNADLSDAS------RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488

Query: 780 LVKPG------DENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVR 822
           L + G      ++   +++KK++  L+ QL +    ++D+E LS+E++R
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEK-LQTQLEREKQSNQDLETLSEELIR 536


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score =  113 bits (283), Expect = 6e-25
 Identities = 182/874 (20%), Positives = 372/874 (42%), Gaps = 124/874 (14%)

Query: 5    LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
            L+EE FQR+ A              E  +   EL  LR+ +  ++      ++ L  + +
Sbjct: 262  LTEENFQRLHA--------------EHERQAKELFLLRKTLEEMELRIETQKQTL--NAR 305

Query: 65   AQEVEVLLSENEMLQAK---LHSQEEDFRLQNSTLMAEF--SKLCSQMEQLEQENQQLKE 119
             + ++ LL   EMLQ+K     + EED         AE     L S +EQ E+EN  L+E
Sbjct: 306  DESIKKLL---EMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLRE 362

Query: 120  GAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                              +  + EN        ALQ     +  K S++  G        
Sbjct: 363  E-----------------MHRRFENAPDSAKTKALQTVIEMKDSKISSMERG-------- 397

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSR-----LQEELAKLSEK 234
                     L ++E + +M K    L  E+ +  E  KQ E  R     ++ ++ ++ ++
Sbjct: 398  ---------LRDLEEEIQMLKSNGALSTEERE--EEMKQMEVYRSHSKFMKNKIGQVKQE 446

Query: 235  LKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-DHKAQLARTQ------KLQQE 284
            L +K      LQT+ ETL   F+DS+  IE L++   A + +A + +T+      +L+++
Sbjct: 447  LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 506

Query: 285  LEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADA---QEQVEGLLAENNALRTS 341
                N+   +++D  + E+   A  +  L+D + ++       Q+++E L  +       
Sbjct: 507  ETMLNKKTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQ 565

Query: 342  LAAL-EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSR 400
            +++L E++++ +    N     TT L   L +++   E L  Q+D    + QE +     
Sbjct: 566  MSSLKERVKSLQADTTNTDTALTT-LEEALAEKERTIERLKEQRDRDEREKQEEI---DN 621

Query: 401  LLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEK 460
              + L+++ ++   L  +L E   S    K     LA   L++ S+ K     + L  +K
Sbjct: 622  YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL--EIALEQKK 679

Query: 461  EVLGVRARYERELRELHED--KKRQEEELRGQIRE-EKARTR---ELETLQQTVEELQAQ 514
            E      + E +L++ HE   + R   E+  +I+  E+  TR   E    Q  V+ L   
Sbjct: 680  EEC---LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEI 736

Query: 515  VHSMDGAKGWFERRLKEAEESLQQQQQE------QEEALKQCREQHAAELKGKEEELQDV 568
            +  ++  K   ++++ E E  ++ Q ++      +E+  K+   Q   E + +E+ L D 
Sbjct: 737  LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 796

Query: 569  RDQLEQAQEERDCHLKTI-SSLKQEVKDTVDGQRILEKKGSAALKDLKR--QLHLERKRA 625
              QL+ +  ++D  ++ +  +L++ V+ T + + +L ++ SA     K+  +L +  ++ 
Sbjct: 797  SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 856

Query: 626  DKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVP 685
             +  E ++  L++++     +E  L+ + +  R    +   +   +    + EK+++ + 
Sbjct: 857  KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDAN-IA 915

Query: 686  ARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVK--HLEVSSASMAEDL 743
               LSSS +      A L  E+   + Q   +TQ    ++ +  +  H + S ++     
Sbjct: 916  LLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK 975

Query: 744  CRKSAIIETYVM--DSRIDVSVAAGHT-----DRSGLGSVLRDLVKPGDENL-------- 788
                 II+  +    +R  + +  GH      DR  L  +LR L  P   NL        
Sbjct: 976  PSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPL--ILRGLTPPASYNLDDDQAAWE 1033

Query: 789  REMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVR 822
             E+ K  +  L+++L K    + +++  +  I++
Sbjct: 1034 NELQKMTRGQLQDELEKGERDNAELQEFANAILQ 1067



 Score =  100 bits (250), Expect = 4e-21
 Identities = 167/774 (21%), Positives = 317/774 (40%), Gaps = 96/774 (12%)

Query: 13  MQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA------Q 66
           +Q QL E+   N  L  ++     +L+S    +        K ++AL K + +      +
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213

Query: 67  EVEVLLSENEMLQAKLHSQEEDFRLQNST---------------LMAEFSKLCSQMEQLE 111
           +  V+  EN+ +Q  + + +++ R+Q                   +AE ++   Q    E
Sbjct: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273

Query: 112 QENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEG 171
            E Q  +       + +    ++ +   L A + +++K +  LQ +     G  +  +E 
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK-----GLSAKATEE 328

Query: 172 QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGL--ESSKQAETSRLQEELA 229
             +     A    A M +  +E   E +++E  +L E++      +   A+T  LQ  + 
Sbjct: 329 DHERTRRLAE---AEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIE 385

Query: 230 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKE------ADHKAQLARTQKLQQ 283
               K+   +     L+ E + L ++     EE ++  +      +  K    +  +++Q
Sbjct: 386 MKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQ 445

Query: 284 ELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL-AENNALRTSL 342
           EL   +  L  L  Q + E L +  +      +V  +S  A+EQ   +L  E +ALR  L
Sbjct: 446 ELSRKDTELLAL--QTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 503

Query: 343 AALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLL 402
              E +   KT+++  + E+    A E+     + +D++  K+   + LQ+ +       
Sbjct: 504 EEKETMLNKKTKQIQDMAEEKGTQAGEIH----DLKDMLDVKERKVNVLQKKI------- 552

Query: 403 EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAM---ETLQEKSQHKEELGAVRLRHE 459
           E LQE  ++KE+    L+E  KS +      D       E L EK +  E L   R R E
Sbjct: 553 ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 612

Query: 460 KEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMD 519
           +E       Y+++L++L    K +   L+G + E++A   +L+          A   +  
Sbjct: 613 REKQEEIDNYKKDLKDL----KEKVSLLQGDLSEKEASLLDLKE--------HASSLASS 660

Query: 520 GAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGK------------EEELQD 567
           G K   + RLK  E +L+Q+++E  +   Q ++ H A L+ +            E E+  
Sbjct: 661 GLKK--DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITR 718

Query: 568 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 627
            +D+  +AQ E D  L+ +  ++ E  D        +KK    + +L+RQ+  + K+   
Sbjct: 719 YKDESSKAQAEVDRLLEILKEVENEKNDK-------DKK----IAELERQVKDQNKKVAN 767

Query: 628 LQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPAR 687
           L+ + Q  +   KS   LEE    E N    +Q    S        E L E    +V   
Sbjct: 768 LKHKEQ--VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQIT 825

Query: 688 SLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAE 741
           +      AQ       ++++V EL   + + +QE   LE     L  +  S+AE
Sbjct: 826 AEREMVLAQEESARTNAEKQVEELLMAMEKVKQE---LESMKAKLSSTQQSLAE 876



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 144/585 (24%), Positives = 253/585 (43%), Gaps = 98/585 (16%)

Query: 4   ALSEEEFQRMQAQLLELRTNNY-------QLSDELRKNGVELTSLRQKVAYLDKEFSKAQ 56
           ALS EE +    Q+   R+++        Q+  EL +   EL +L+ K+  L  +FS ++
Sbjct: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 472

Query: 57  KALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQ 116
           + +   K++      L+  E   A L ++ +  RL          +L  +   L ++ +Q
Sbjct: 473 QHIEVLKES------LTAKEQRAAILQTEVDALRL----------RLEEKETMLNKKTKQ 516

Query: 117 LKEGAAGAGVAQAGPLVD-GELLRLQAENT-ALQKNVAALQERYGKEAGKFSAVSEG--- 171
           +++ A   G  QAG + D  ++L ++      LQK +  LQE+   +  + S++ E    
Sbjct: 517 IQDMAEEKGT-QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575

Query: 172 -QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAK 230
            Q D              LAE E   E  KE++     + Q    + + +   L+E+++ 
Sbjct: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635

Query: 231 LSEKLKKKQESFCRLQTEKETLFN-----DSRNKIEE--LQQRKEADHKAQLARTQKLQQ 283
           L   L +K+ S   L+    +L +     DSR K  E  L+Q+KE           K++ 
Sbjct: 636 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKE--------ECLKMES 687

Query: 284 ELEAANQSLAELR-DQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLA-------EN 335
           +L+ A+++  E R      +R++H   L     +   +S+ AQ +V+ LL        E 
Sbjct: 688 QLKKAHEAALEARASPEMSDRIQH---LEREITRYKDESSKAQAEVDRLLEILKEVENEK 744

Query: 336 NALRTSLAALEQI---QTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 392
           N     +A LE+    Q  K   L    +     +A++ ++    ED +   +D + QLQ
Sbjct: 745 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL---NDSSQQLQ 801

Query: 393 ESLRANSRLLEQLQEIGQEKEQLTQEL-------QEARKSAEKR---------------- 429
           +SLR     +E+L+E  +E  Q+T E        + AR +AEK+                
Sbjct: 802 DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 861

Query: 430 --KAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVR------ARYERE----LRELH 477
             KA L     ++L EK  H   L A R +H +EVL ++      A  E++    L EL 
Sbjct: 862 SMKAKLSS-TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELS 920

Query: 478 EDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAK 522
             KK+ +EE+    RE+    ++L+   Q   +L A  +  D  K
Sbjct: 921 SSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFK 965



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 98/498 (19%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
            +EE    +  L +L+     L  +L +    L  L++  + L      A   L K  + +
Sbjct: 616  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL------ASSGLKKDSRLK 669

Query: 67   EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFS-KLCSQMEQLEQENQQLKEGAAGAG 125
             +E+ L + +    K+ SQ +  +   + L A  S ++  +++ LE+E  + K+ ++ A 
Sbjct: 670  TLEIALEQKKEECLKMESQLK--KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 727

Query: 126  VAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLA 185
             A+   L++  L  ++ E     K +A L ER  K+  K                     
Sbjct: 728  -AEVDRLLE-ILKEVENEKNDKDKKIAEL-ERQVKDQNK--------------------- 763

Query: 186  PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 242
               +A ++ K ++EK++   + E+ +  E +    + +LQ+ L K  +++++ +E+    
Sbjct: 764  --KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 821

Query: 243  CRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGE 302
             ++  E+E +        E  +   E   +  L   +K++QELE+    L+  + Q   E
Sbjct: 822  VQITAEREMVLAQE----ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ-QSLAE 876

Query: 303  RLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT--QELNMLR 360
            +  H   LRA + +   +  + ++  E LLA  +    ++A LE   + K   +E+  L+
Sbjct: 877  KETHLTNLRAERRKHLEEVLEMKQ--EALLAAISEKDANIALLELSSSKKKTQEEVAALK 934

Query: 361  EQTTGLAAELQQQQAEYEDLMGQK-DDLNSQLQESLRANSR-----LLEQLQEIGQEKEQ 414
             +   L  +L+QQ      LM    +D + +   S + N +     +++ L E+ Q + +
Sbjct: 935  REKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSK 994

Query: 415  LTQ---------------------------------------------ELQEARKSAEKR 429
            L                                               +LQ+  +  E+ 
Sbjct: 995  LKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERD 1054

Query: 430  KAMLDELAMETLQEKSQH 447
             A L E A   LQ+ + H
Sbjct: 1055 NAELQEFANAILQQIADH 1072


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  113 bits (283), Expect = 6e-25
 Identities = 210/917 (22%), Positives = 393/917 (42%), Gaps = 156/917 (17%)

Query: 7    EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQK-------AL 59
            EE    +++++ E    N  L +E +K    +  L ++   LD+E    QK       A 
Sbjct: 921  EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ---LDEEEGARQKLQLEKVTAE 977

Query: 60   SKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQL-- 117
            +K KK +E  +LL +      K     ED   + S+ +AE  +    + ++  + + +  
Sbjct: 978  AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037

Query: 118  -------KEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFS-AVS 169
                   KE      + +A   +DGE   LQ +   LQ  +  L+ +  K+  +   A++
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097

Query: 170  EGQGDP-PGGPAPTVLAPMP--LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQE 226
             G  +      A  V+  +   +AE++  +E EK  +    +Q + L    +A  + L++
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157

Query: 227  EL---AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ 283
             L   A   E   K+++    L+   E    +   +I++++QR    H   L   ++L +
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR----HATAL---EELSE 1210

Query: 284  ELEAANQSLAELRDQRQG---ERLEHAAALRALQDQVSIQSA------DAQ-EQVEGLLA 333
            +LE A +  A L   +QG   +  E A  ++ LQ QV  +S       DAQ +++   ++
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ-QVKAESEHKRKKLDAQVQELHAKVS 1269

Query: 334  ENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQE 393
            E + LR  LA        +   ++ L E+      +  +  A  E    Q  D    LQE
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES---QLQDTQELLQE 1326

Query: 394  SLRANSRLLEQLQEIGQEKEQLT---QELQEARKSAEK------------RKAMLDEL-A 437
              R    L  +++++ +EK  L    +E +EARK+ EK            +K + D+L  
Sbjct: 1327 ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT 1386

Query: 438  METLQEK-----------SQHKEELGAV---------RLRHEKEVLGVRARYERELRELH 477
            +E+L+E            SQ  EE             RL+ E + L V   ++R++    
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446

Query: 478  EDKKR-------QEEELRGQIREEK----ARTRELET--------LQQTVE--------- 509
            E K++       +E+ +  +  EE+    A  RE ET        L++ +E         
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506

Query: 510  -ELQAQVHSMDGAKGWFERRLKEAEES---LQQQQQEQEEALKQCREQHAAELKGK---E 562
             +L+A +  +  +K    + + E E+S   L+QQ +E    L++  ++  A    K   E
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566

Query: 563  EELQ--------DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRIL----EKKGSAA 610
              +Q        D++ + EQ +E++   +K +  L+ E++D    QR L    +KK    
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE-RKQRALAVASKKKMEID 1625

Query: 611  LKDLKRQLHLERKRADKLQERLQDILTNSKS-RSGLEELVLS--EMNSPSRTQTGDSSSI 667
            LKDL+ Q+    K  D++ ++L+ +    K  +  LEE   S  E+ + S+       S+
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685

Query: 668  SSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEE 727
             +    EIL+ +E        L+SS +A+  R AE   +E+A+    +  +   K  L +
Sbjct: 1686 EA----EILQLQE-------ELASSERAR--RHAEQERDELAD---EITNSASGKSALLD 1729

Query: 728  KVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGD-- 785
            + + LE   A + E+L  + + +E  +++ R   +     T  + L +  R   +  D  
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNME--LLNDRFRKTTLQVDTLNAELAAE-RSAAQKSDNA 1786

Query: 786  -ENLREMNKKLQNMLEE 801
             + L   NK+L+  L+E
Sbjct: 1787 RQQLERQNKELKAKLQE 1803



 Score =  108 bits (271), Expect = 2e-23
 Identities = 155/692 (22%), Positives = 303/692 (43%), Gaps = 85/692 (12%)

Query: 189  LAEVELKWEMEKEEKRLLWEQLQG----------LESSKQAETSRLQEELAKLSEKLKKK 238
            L E+E K +   EEK +L EQLQ           + +   A+   L+E L  L  +++++
Sbjct: 875  LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE 934

Query: 239  QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQ 298
            +E    LQ EK+ +    ++  E+L + + A  K QL +    + +++   + +  L DQ
Sbjct: 935  EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV-TAEAKIKKMEEEILLLEDQ 993

Query: 299  RQGERLEHAAALRALQDQV---SIQSADAQEQVEGLLAENNALRTSLAALEQ---IQTAK 352
                  +     + ++D++   S Q A+ +E+ + L    N     ++ LE+    +   
Sbjct: 994  NS----KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049

Query: 353  TQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQL---------------QESLRA 397
             QEL   + +  G   +LQ Q AE   L  Q D+L  QL                E+L  
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAE---LQAQIDELKLQLAKKEEELQGALARGDDETLHK 1106

Query: 398  NS--RLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGA-- 453
            N+  +++ +LQ    E ++  +  + +R  AEK+K  L E  +E L+ + +   +  A  
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE-ELEALKTELEDTLDTTAAQ 1165

Query: 454  --VRLRHEKEVLGVR-------ARYERELRELHEDKKRQEEELRGQIREEKARTRELETL 504
              +R + E+EV  ++         +E +++++ +      EEL  Q+ + K     LE  
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225

Query: 505  QQTVE----ELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKG 560
            +Q +E    EL  +V  +   K   E + K+ +  +Q+   +  E   + R + A +   
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEG-DRLRVELAEKASK 1284

Query: 561  KEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHL 620
             + EL +V   LE+A+++     K  +SL+ +++DT   Q +L+++    L    R   L
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIRQL 1341

Query: 621  ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKE 680
            E ++ + LQE+ ++     ++R  LE+ VL+  +  + T+      + +    E  ++K 
Sbjct: 1342 EEEK-NSLQEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 681  SSAVPARSLSSSPQAQPPRPAELS----DEEVAELFQRLAETQQEKWMLEEKVKHLEVSS 736
                 A S     +A      E +     +E+ +L   L   +Q    LE+K K  +   
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD--- 1454

Query: 737  ASMAEDLCRKSAIIETYVMD-SRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKL 795
                + L  + +I   Y  +  R +       T    L   L + ++  +E  R+ NK+L
Sbjct: 1455 ----QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ-NKQL 1509

Query: 796  QNMLEEQLT------KNMH-LHKDMEVLSQEI 820
            +  +E+ ++      KN+H L K    L Q++
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541



 Score =  102 bits (253), Expect = 2e-21
 Identities = 156/691 (22%), Positives = 302/691 (43%), Gaps = 124/691 (17%)

Query: 3    QALSEEEFQRMQAQLLELR---TNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL 59
            +A SE + +++ AQ+ EL    +   +L  EL +   +L +    V+ L +E  K  K +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGI 1304

Query: 60   SKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKE 119
              +K A  +E  L + + L      QEE  +  N         L S++ QLE+E   L+E
Sbjct: 1305 KFAKDAASLESQLQDTQELL-----QEETRQKLN---------LSSRIRQLEEEKNSLQE 1350

Query: 120  GAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGP 179
                   A+           L+ +  ALQ  +A  +++   + G   ++ E         
Sbjct: 1351 QQEEEEEARKN---------LEKQVLALQSQLADTKKKVDDDLGTIESLEE--------- 1392

Query: 180  APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL---AKLSEKLK 236
                 A   L +         EEK L +++L+  ++  Q E   L  +L    +++  L+
Sbjct: 1393 -----AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447

Query: 237  KKQESFCRLQTEKETL---FNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQ 290
            KKQ+ F +L  E++++   + + R++ E   + KE    +    L    + ++E E  N+
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507

Query: 291  SL-AELRDQRQ-----GERL-EHAAALRALQDQVSIQSADAQEQVEGLLAENNA---LRT 340
             L A++ D        G+ + E   + RAL+ QV       +E  + L A  +A   L  
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 341  SLAALE-----QIQTAKTQ---ELNMLREQTTGLAAELQQQQAEYEDLMGQKD------- 385
            ++ A++      +QT   Q   +  +L +Q   L AEL+ ++ +    +  K        
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627

Query: 386  DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK--RKAMLDELAMETLQ- 442
            DL +Q++ + +A   +++QL+++  + +   +EL+EAR S ++   ++   E  +++L+ 
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687

Query: 443  EKSQHKEELGA---VRLRHEKE-----------------VLGVRARYERELRELHEDKKR 482
            E  Q +EEL +    R   E+E                 +L  + R E  + +L E+ + 
Sbjct: 1688 EILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747

Query: 483  QEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQE 542
            ++  +       +  T +++TL   +   ++     D A+   ER+ KE +  LQ    E
Sbjct: 1748 EQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ----E 1803

Query: 543  QEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRI 602
             E A+K    +  A +   E ++  + +QLEQ  +ER    K +              R 
Sbjct: 1804 LEGAVKS---KFKATISALEAKIGQLEEQLEQEAKERAAANKLV--------------RR 1846

Query: 603  LEKKGSAALKDLKRQLHLERKRADKLQERLQ 633
             EKK    LK++  Q+  ER+ AD+ +E+++
Sbjct: 1847 TEKK----LKEIFMQVEDERRHADQYKEQME 1873



 Score =  100 bits (249), Expect = 6e-21
 Identities = 130/646 (20%), Positives = 287/646 (44%), Gaps = 72/646 (11%)

Query: 196  WEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFND 255
            W +  + K LL  Q+   E   QA+     EEL K+ EK  K +     ++ + + L  +
Sbjct: 835  WRVFTKVKPLL--QVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE 888

Query: 256  SRNKIEELQQRKE--ADHKAQLARTQKLQQELEAA---NQSLAELRDQR----QGERLEH 306
                 E+LQ   E  A+ +   AR    +QELE      +S  E  ++R    Q E+ + 
Sbjct: 889  KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948

Query: 307  AAALRALQDQVSIQSADAQE-QVEGLLAEN--NALRTSLAALEQIQTAKTQELNMLREQT 363
             A ++ L++Q+  +    Q+ Q+E + AE     +   +  LE   +   +E  ++ ++ 
Sbjct: 949  QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008

Query: 364  TGLAAELQQQQAEYEDL---MGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 420
               +++L +++ + ++L     +++ + S L+E L+   +  ++L++  ++ +  T +LQ
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 421  EARKSAEKRKAMLDELAMETLQEKSQHKEEL--GAVRLRHEKEVLGVRARYERELRELHE 478
            +      + +A +DEL ++  +++ + +  L  G     H+   L V    + ++ EL E
Sbjct: 1069 D---QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 479  DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQ 538
            D + ++       ++++  + ELE L+  +E+      +    +   E+ + E +++L++
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185

Query: 539  QQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 598
            + +  E  ++  R++HA         L+++ +QLEQA+  +    K    L+ + K+   
Sbjct: 1186 ETKNHEAQIQDMRQRHAT-------ALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238

Query: 599  GQRILEKKGSAALKDLKRQLHLERKRAD-KLQERLQDILTNSKSRSGLEELVLSEMNSPS 657
              ++L++        +K +   +RK+ D ++QE    +    + R  L E      N   
Sbjct: 1239 EVKVLQQ--------VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290

Query: 658  RTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAE---LFQR 714
               T             +L E E   +     ++S ++Q     EL  EE  +   L  R
Sbjct: 1291 NVST-------------LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337

Query: 715  LAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLG 774
            + + ++EK  L+E+ +  E       ++L ++   +++ + D++  V           LG
Sbjct: 1338 IRQLEEEKNSLQEQQEEEE----EARKNLEKQVLALQSQLADTKKKVD--------DDLG 1385

Query: 775  SVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEI 820
            ++  + ++   + L +  + L   LEE+      L K    L QE+
Sbjct: 1386 TI--ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 140/647 (21%), Positives = 280/647 (43%), Gaps = 125/647 (19%)

Query: 2    AQALSEEEFQRMQAQLL---ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
            A+ALS    QR++ + L   +L     +L  EL    V+L   RQ  + L+K+  K  + 
Sbjct: 1401 AEALS----QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456

Query: 59   LSKSK---------------KAQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSK 102
            L++ K               +A+E E   LS    L+  L ++EE F  QN  L A+   
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE-FERQNKQLRADMED 1515

Query: 103  LCSQMEQLEQENQQLKEG--AAGAGVAQAGPLVDGELLRLQAENTA---LQKNVAALQER 157
            L S  + + +   +L++   A    V +    ++     LQA   A   L+ N+ A++ +
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575

Query: 158  YGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK 217
            + ++                              ++ + E  +E+KRLL +Q++ LE+  
Sbjct: 1576 FERD------------------------------LQTRDEQNEEKKRLLIKQVRELEA-- 1603

Query: 218  QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--- 274
            + E  R Q  LA  S   KKK E                   +++L+ + EA +KA+   
Sbjct: 1604 ELEDERKQRALAVAS---KKKMEI-----------------DLKDLEAQIEAANKARDEV 1643

Query: 275  LARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAE 334
            + + +KLQ +++   + L E R  R               D++  QS +++++++ L AE
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASR---------------DEIFAQSKESEKKLKSLEAE 1688

Query: 335  NNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 394
               L+  LA+ E+ +    QE + L ++ T  A+       E   L  +   L  +L+E 
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748

Query: 395  LRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 454
                  L ++ ++   + + L  EL   R +A+K      +L  +  + K++ +E  GAV
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 455  RLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQ 514
            + + +  +  + A+             + EE+L  + +E  A  + +   ++ ++E+  Q
Sbjct: 1809 KSKFKATISALEAKI-----------GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857

Query: 515  VHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQ 574
            V         ++ ++++A   ++Q +++ EEA ++    +A+  K        ++ +L+ 
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK--------LQRELDD 1909

Query: 575  AQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLE 621
            A E  +   + +S+LK  ++    G  I      ++ +  +RQLHLE
Sbjct: 1910 ATEANEGLSREVSTLKNRLR---RGGPI----SFSSSRSGRRQLHLE 1949



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 123/575 (21%), Positives = 255/575 (44%), Gaps = 62/575 (10%)

Query: 275  LARTQKLQQELEAANQSLAELRDQR---QGERLEHAAALRALQDQVSIQSADAQEQVEGL 331
            L +  + ++EL+A ++ L ++++++   +GE  E     + L ++ +I +   Q + E L
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE-L 902

Query: 332  LAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQL 391
             AE   +R  LAA +Q                     EL++   + E  + ++++ N  L
Sbjct: 903  FAEAEEMRARLAAKKQ---------------------ELEEILHDLESRVEEEEERNQIL 941

Query: 392  QESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAE-KRKAMLDELAM------ETLQEK 444
            Q   +     ++ L+E   E+E   Q+LQ  + +AE K K M +E+ +      + ++EK
Sbjct: 942  QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001

Query: 445  SQHKEELG--AVRLRHEKE----VLGVRARYERELRELHEDKKRQEEELRGQIREEKAR- 497
               ++ +   + +L  E+E    +  +R + E  + +L E++ ++EE+ R ++ + K + 
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL-EERLKKEEKTRQELEKAKRKL 1060

Query: 498  TRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAE 557
              E   LQ  + ELQAQ+  +       E  L+ A      +   +  ALK  RE   A+
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ-AQ 1119

Query: 558  LKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD---GQRILEKKGSAALKDL 614
            +   +E+ +  +    +A++++    + + +LK E++DT+D    Q+ L  K    + +L
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179

Query: 615  KRQLHLERKRAD-KLQERLQDILTNSKSRS-GLEELVLSEMNSPSRTQTGDSSSISSFSY 672
            K+ L  E K  + ++Q+  Q   T  +  S  LE+    + N     Q  ++ +      
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239

Query: 673  REILRE-KESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKH 731
             ++L++ K  S    + L +  Q    + +E  D    EL ++ ++ Q E   +   ++ 
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSE-GDRLRVELAEKASKLQNELDNVSTLLEE 1298

Query: 732  LEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREM 791
             E      A+D    +A +E+ + D++    +      +  L S +R         L E 
Sbjct: 1299 AEKKGIKFAKD----AASLESQLQDTQ--ELLQEETRQKLNLSSRIR--------QLEEE 1344

Query: 792  NKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKE 826
               LQ   EE+     +L K +  L  ++    K+
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 97/449 (21%), Positives = 183/449 (40%), Gaps = 45/449 (10%)

Query: 1    MAQALSE-----EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA 55
            +A+AL E     EEF+R   QL     +     D++ KN  EL   ++ +    +E    
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 56   QKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQ 115
             + L    +A E   L  E  M QA     E D + ++     +   L  Q+ +LE E +
Sbjct: 1548 LEELEDELQATEDAKLRLEVNM-QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606

Query: 116  QLKEGAAGAGVAQAGPLVD-------------------GELLRLQAENTALQKNVAALQE 156
              ++  A A  ++    +D                    +L +LQA+    Q+    L+E
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE---LEE 1663

Query: 157  RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESS 216
                    F+   E +       A  +     LA  E      ++E+  L +++    S 
Sbjct: 1664 ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG 1723

Query: 217  KQA---ETSRLQEELAKLSEKLKKKQESFCRL--QTEKETLFNDSRNKIEELQQRKEADH 271
            K A   E  RL+  +A+L E+L+++Q +   L  +  K TL  D+ N   EL   + A  
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN--AELAAERSAAQ 1781

Query: 272  KAQLARTQKLQQELEAANQSL-AELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 330
            K+  AR     Q+LE  N+ L A+L++     + +  A + AL+ ++       +++ + 
Sbjct: 1782 KSDNAR-----QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836

Query: 331  LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQ 390
              A N  +R +   L++I      E    R        ++++  A  + L  Q ++   +
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDE----RRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892

Query: 391  LQESLRANSRLLEQLQEIGQEKEQLTQEL 419
               +  +  +L  +L +  +  E L++E+
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREV 1921


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.123    0.316 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,840,804
Number of Sequences: 37866
Number of extensions: 1473580
Number of successful extensions: 39848
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 721
Number of HSP's successfully gapped in prelim test: 1508
Number of HSP's that attempted gapping in prelim test: 10674
Number of HSP's gapped (non-prelim): 10555
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.