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Search of human proteins with 46370073
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
(694 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa... 1431 0.0
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa... 1415 0.0
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 431 e-120
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap... 359 4e-99
gi|126091130 Gab3 protein isoform 1 [Homo sapiens] 244 3e-64
gi|18079323 Gab3 protein isoform 2 [Homo sapiens] 243 4e-64
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 169 1e-41
gi|50234893 pleckstrin homology domain containing, family A (pho... 56 1e-07
gi|31377720 pleckstrin homology domain containing, family A (pho... 56 1e-07
gi|55741447 pleckstrin homology domain containing, family H (wit... 54 6e-07
gi|154354979 myosin X [Homo sapiens] 53 1e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 50 7e-06
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 49 2e-05
gi|197313732 pleckstrin homology-like domain, family B, member 2... 49 2e-05
gi|197313730 pleckstrin homology-like domain, family B, member 2... 49 2e-05
gi|197313728 pleckstrin homology-like domain, family B, member 2... 49 2e-05
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 49 2e-05
gi|156616273 pleckstrin [Homo sapiens] 48 3e-05
gi|5031805 insulin receptor substrate 1 [Homo sapiens] 47 5e-05
gi|38683860 insulin receptor substrate 2 [Homo sapiens] 47 6e-05
gi|217416392 pleckstrin homology domain containing, family H (wi... 47 6e-05
gi|154146216 pleckstrin homology domain containing, family A (ph... 47 6e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 46 1e-04
gi|116284392 mucin 2 precursor [Homo sapiens] 45 2e-04
gi|221219026 pleckstrin homology-like domain, family B, member 1... 45 2e-04
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens] 45 2e-04
gi|47132519 Ras association and pleckstrin homology domains 1 is... 44 4e-04
gi|221219024 pleckstrin homology-like domain, family B, member 1... 44 7e-04
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 44 7e-04
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 44 7e-04
>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
sapiens]
Length = 694
Score = 1431 bits (3704), Expect = 0.0
Identities = 694/694 (100%), Positives = 694/694 (100%)
Query: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
Sbjct: 61 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
Query: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
Sbjct: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
Query: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
Sbjct: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
Query: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
Sbjct: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
Query: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
Sbjct: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
Query: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
Sbjct: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
Query: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
Sbjct: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
Query: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLP 540
DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLP
Sbjct: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLP 540
Query: 541 EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSED 600
EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSED
Sbjct: 541 EWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSED 600
Query: 601 PNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYV 660
PNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYV
Sbjct: 601 PNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYV 660
Query: 661 VVDQQKTLALKSTREAWTDGRQSTESETPAKSVK 694
VVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
Sbjct: 661 VVDQQKTLALKSTREAWTDGRQSTESETPAKSVK 694
>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
Length = 724
Score = 1415 bits (3663), Expect = 0.0
Identities = 694/724 (95%), Positives = 694/724 (95%), Gaps = 30/724 (4%)
Query: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
Sbjct: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
Query: 61 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
Sbjct: 61 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
Query: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
Sbjct: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
Query: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
Sbjct: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
Query: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
Sbjct: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
Query: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
Sbjct: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
Query: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
Sbjct: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
Query: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
Sbjct: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
Query: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD-------------- 526
DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
Sbjct: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH 540
Query: 527 ----------------RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 570
RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
Sbjct: 541 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 600
Query: 571 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 630
DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
Sbjct: 601 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 660
Query: 631 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 690
DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
Sbjct: 661 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 720
Query: 691 KSVK 694
KSVK
Sbjct: 721 KSVK 724
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 431 bits (1107), Expect = e-120
Identities = 286/719 (39%), Positives = 391/719 (54%), Gaps = 77/719 (10%)
Query: 3 GGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDL 62
GG+VVC+GWLRKSPPEKKL+RYAWK+RWF+LRSGR++GDPDVLEYYKNDH+KKP+RII+L
Sbjct: 4 GGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL 63
Query: 63 NLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEE 122
N C+QVDAGLTFNKKE ++S++FDI T +R FYLVA++EE+MNKWV+ IC ICGFN EE
Sbjct: 64 NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
Query: 123 --DPVKPPGSSLQAPADLPLAIN-----------TAPPSTQADSSSATLPPPYQLINVPP 169
D ++ S+ P P ++ ++ PS + + T PP V
Sbjct: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPP-----VSN 178
Query: 170 HLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSK 229
H++ PQ+YL L C S++ E R+ + S + +S +D +
Sbjct: 179 HMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
Query: 230 HGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGE-LYVFN 288
+G++G Q Y P + S Y+LPRS + K S + +E D E +Y F
Sbjct: 239 NGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFK 296
Query: 289 TPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD------IPP 342
TPS T E V + D+P TP + YQIPRTF TL + T+ PP
Sbjct: 297 TPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF---TLDKNHNAMTVATPGDSAIAPP 352
Query: 343 PRPPKPHPAHD---RSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399
PRPPKP A SP + I + ++ IP R NT+ +D ++L +
Sbjct: 353 PRPPKPSQAETPRWGSPQQRPPISENSRSVAAT--IP-------RRNTLPAMDNSRLHR- 402
Query: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNVLTVGSVSSEELDENYVPMNPNSPPR 457
ASS + Y+ P+ S E + + + VG S ++NYVPMNP S
Sbjct: 403 ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTL 462
Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
+ Q Y+PM+PG F S +G+ S+ R P ++ +PP
Sbjct: 463 LAMERAGDNSQSV-YIPMSPGAHHFDS----------LGYPSTTLPVHRGPSRGSEIQPP 511
Query: 518 PVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSP----RPDSV 573
PV+RNLKPDRK KP PL+++ +EL P +SPIT+S++R + F S RP S
Sbjct: 512 PVNRNLKPDRKAKPTPLDLRNNTVIDEL--PFKSPITKSWSRANHTFNSSSSQYCRPIST 569
Query: 574 HSTTSSSDSHDSEENYVPM-NPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDL 632
S T S+DS DSEENYVPM NP +S P+ G +SP K K V+YL LD
Sbjct: 570 QSIT-STDSGDSEENYVPMQNPVSASPVPS--------GTNSPAPK-KSTGSVDYLALDF 619
Query: 633 DSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAK 691
+P RK +S S +DE+VDYV VD++KT AL++T + WTD RQS+E AK
Sbjct: 620 QPSSPSPHRKPSTS---SVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAK 675
>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
sapiens]
Length = 638
Score = 359 bits (922), Expect = 4e-99
Identities = 256/684 (37%), Positives = 356/684 (52%), Gaps = 77/684 (11%)
Query: 38 LTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLV 97
++GDPDVLEYYKNDH+KKP+RII+LN C+QVDAGLTFNKKE ++S++FDI T +R FYLV
Sbjct: 1 MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLV 60
Query: 98 ADSEEEMNKWVRCICDICGFNPTEE--DPVKPPGSSLQAPADLPLAIN-----------T 144
A++EE+MNKWV+ IC ICGFN EE D ++ S+ P P ++ +
Sbjct: 61 AETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKS 120
Query: 145 APPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSA 204
+ PS + + T PP V H++ PQ+YL L C S++ E R+ + S
Sbjct: 121 SAPSHSSQPTLFTFEPP-----VSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQ 175
Query: 205 KSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRS 264
+ +S +D + +G++G Q Y P + S Y+LPRS
Sbjct: 176 GTRASFLMRSDTAVQKLAQGNGHCVNGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRS 233
Query: 265 YSHDVLPKVSPSSTEADGE-LYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTF 323
+ K S + +E D E +Y F TPS T E V + D+P TP + YQIPRTF
Sbjct: 234 LASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF 292
Query: 324 PEGTLGQTSKLDTIPD------IPPPRPPKPHPAHD---RSPVETCSIPRTASDTDSSYC 374
TL + T+ PPPRPPKP A SP + I + ++
Sbjct: 293 ---TLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAAT-- 347
Query: 375 IPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNV 432
IP R NT+ +D ++L + ASS + Y+ P+ S E + +
Sbjct: 348 IP-------RRNTLPAMDNSRLHR-ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGK 399
Query: 433 LTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPP 492
+ VG S ++NYVPMNP S + Q Y+PM+PG F S
Sbjct: 400 MIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSV-YIPMSPGAHHFDS-------- 450
Query: 493 AHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSP 552
+G+ S+ R P ++ +PPPV+RNLKPDRK KP PL+++ +EL P +SP
Sbjct: 451 --LGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDEL--PFKSP 506
Query: 553 ITRSFARDSSRFPMSP----RPDSVHSTTSSSDSHDSEENYVPM-NPNLSSEDPNLFGSN 607
IT+S++R + F S RP S S T S+DS DSEENYVPM NP +S P+
Sbjct: 507 ITKSWSRANHTFNSSSSQYCRPISTQSIT-STDSGDSEENYVPMQNPVSASPVPS----- 560
Query: 608 SLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKT 667
G +SP K K V+YL LD +P RK +S S +DE+VDYV VD++KT
Sbjct: 561 ---GTNSPAPK-KSTGSVDYLALDFQPSSPSPHRKPSTS---SVTSDEKVDYVQVDKEKT 613
Query: 668 LALKSTREAWTDGRQSTESETPAK 691
AL++T + WTD RQS+E AK
Sbjct: 614 QALQNTMQEWTDVRQSSEPSKGAK 637
>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
Length = 587
Score = 244 bits (622), Expect = 3e-64
Identities = 210/699 (30%), Positives = 316/699 (45%), Gaps = 130/699 (18%)
Query: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQE- 178
E+ S P+ L ++A A ++S++LP N ET E
Sbjct: 121 LEDGAADSMESLSYTPSS--LQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESEL 178
Query: 179 -DPQDYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------PSHKNPASSQ 227
DYL+L NC++ + PTR + S S E D+V P +
Sbjct: 179 LFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHP 238
Query: 228 SKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVF 287
S HG + P SR +A + S N P
Sbjct: 239 SCHGSGA-------QEVPSSRPQAALIWSREINGP------------------------- 266
Query: 288 NTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTIPDIPPPRPP 346
H+S S + + +T Q+ + +G+L +K LD + + PPPRPP
Sbjct: 267 -----------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIMSNTPPPRPP 313
Query: 347 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY 406
KP +R E T S P + P R + ++ + D Q
Sbjct: 314 KPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLR 365
Query: 407 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP 466
+ + + +S ++++YVPM+P + +S
Sbjct: 366 HRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA----GASGLGPH 409
Query: 467 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD 526
+Y+PM G+ SSP P P A+ EPPPV+R+LKP
Sbjct: 410 CSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPPPVNRDLKPQ 446
Query: 527 RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTT--SSSDSHD 584
RK +P PL+++ L E + R TR+ + F +SP + ++S ++ S +
Sbjct: 447 RKSRPPPLDLRNLSIIREHASLTR---TRTVPCSRTSF-LSPERNGINSARFFANPVSRE 502
Query: 585 SEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQK 644
EE+Y+ M + + ++SL G+ K ++YL LD +S S P +QK
Sbjct: 503 DEESYIEMEEHRT--------ASSLSSGALTWTK---KFSLDYLALDFNSA-SPAPMQQK 550
Query: 645 SSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQS 683
S ++RVDYV VD+QKT AL+ST++ WTD RQS
Sbjct: 551 LLLS----EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 585
>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
Length = 586
Score = 243 bits (620), Expect = 4e-64
Identities = 209/708 (29%), Positives = 318/708 (44%), Gaps = 149/708 (21%)
Query: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60
Query: 61 DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
DL+ C G +F +KEF+N+++F + T R FYLVA +E+EM WV I +C
Sbjct: 61 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120
Query: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVP---PHLETLGI 176
E+ AD +++ P S Q S+S+ L ++P P+ +
Sbjct: 121 LEDG------------ADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 168
Query: 177 QEDPQ--------DYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------P 218
+E DYL+L NC++ + PTR + S S E D+V P
Sbjct: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQP 228
Query: 219 SHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSST 278
+ S HG + P SR +A + S N P
Sbjct: 229 LPSSHLVHPSCHGSGA-------QEVPSSRPQAALIWSREINGP---------------- 265
Query: 279 EADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTI 337
H+S S + + +T Q+ + +G+L +K LD +
Sbjct: 266 --------------------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIM 303
Query: 338 PDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLR 397
+ PPPRPPKP +R E T S P + P R + ++ +
Sbjct: 304 SNTPPPRPPKPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWK 355
Query: 398 KDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPR 457
D Q + + + +S ++++YVPM+P +
Sbjct: 356 ADVEGQSLRHRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA--- 400
Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
+S +Y+PM G+ SSP P P A+ EPP
Sbjct: 401 -GASGLGPHCSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPP 436
Query: 518 PVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTT 577
PV+R+LKP RK +P PL+++ L E + R TR+ + F +SP + ++S
Sbjct: 437 PVNRDLKPQRKSRPPPLDLRNLSIIREHASLTR---TRTVPCSRTSF-LSPERNGINSAR 492
Query: 578 --SSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSG 635
++ S + EE+Y+ M + + ++SL G+ K ++YL LD +S
Sbjct: 493 FFANPVSREDEESYIEMEEHRT--------ASSLSSGALTWTK---KFSLDYLALDFNSA 541
Query: 636 KSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQS 683
S P +QK S ++RVDYV VD+QKT AL+ST++ WTD RQS
Sbjct: 542 -SPAPMQQKLLLS----EEQRVDYVQVDEQKTQALQSTKQEWTDERQS 584
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 169 bits (427), Expect = 1e-41
Identities = 75/120 (62%), Positives = 95/120 (79%), Gaps = 2/120 (1%)
Query: 4 GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
G V+ SGWLRKSPPEKKL+ +AW++RWF+LR G+ + DPDVLEYYKND +KKP+R I+LN
Sbjct: 38 GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97
Query: 64 LCQQ--VDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTE 121
LC+Q VD L FNKKE + Y+FDI T +R FYLVA++ E+MN+WV+ IC ICGF E
Sbjct: 98 LCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQEE 157
Score = 70.5 bits (171), Expect = 5e-12
Identities = 58/177 (32%), Positives = 83/177 (46%), Gaps = 23/177 (12%)
Query: 517 PPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSP--RPDSVH 574
PPV+R+LKP++K P P ++ EL + P+T ++ S F S P S
Sbjct: 418 PPVNRSLKPNQKANPTPPNLRNNRVINELS--FKPPVTEPWSGTSHTFDSSSSQHPISTQ 475
Query: 575 STTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDS 634
S T++ DS DS E Y + PN +S P + GG+S P+ + Y LD
Sbjct: 476 SITNT-DSEDSGERY--LFPNPASAFP-------VSGGTSSSAPPRSTGNIHYAALDFQP 525
Query: 635 GKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAK 691
K + GS + ++VDYV VD +KT AL+ T RQS+E AK
Sbjct: 526 SKPS---------IGSVTSGKKVDYVQVDLEKTQALQKTMHEQMCLRQSSEPPRGAK 573
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 55.8 bits (133), Expect = 1e-07
Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 30/143 (20%)
Query: 26 WKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL------CQQVDAGLTFNKKEF 79
WKRR+F L D + + Y+K++ K+P+R+I L C+Q D + N
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256
Query: 80 ENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK------PPGSSLQ 133
+F+I T R FY+ ADS EEM+ W++ + G + P + PPG S
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKA---VSGAIVAQRGPGRSASSEHPPGPSES 309
Query: 134 APADLPLAINTAPPSTQADSSSA 156
A P TA + A S++
Sbjct: 310 KHAFRPTNAATATSHSTASRSNS 332
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 55.8 bits (133), Expect = 1e-07
Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 30/143 (20%)
Query: 26 WKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL------CQQVDAGLTFNKKEF 79
WKRR+F L D + + Y+K++ K+P+R+I L C+Q D + N
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256
Query: 80 ENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK------PPGSSLQ 133
+F+I T R FY+ ADS EEM+ W++ + G + P + PPG S
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKA---VSGAIVAQRGPGRSASSEHPPGPSES 309
Query: 134 APADLPLAINTAPPSTQADSSSA 156
A P TA + A S++
Sbjct: 310 KHAFRPTNAATATSHSTASRSNS 332
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 53.5 bits (127), Expect = 6e-07
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%)
Query: 1 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58
+ G + SG+L K + K WKRRWFVLR G++ YYK +D +KP
Sbjct: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622
Query: 59 IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
+DLN Q+ G E S F + + + +YL ADS + +W+R +
Sbjct: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/111 (28%), Positives = 54/111 (48%), Gaps = 15/111 (13%)
Query: 5 EVVCSGWL-RKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
E + GWL +K L R WK+RWFVLR +L Y++ND +K +++
Sbjct: 1212 EALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLM-------YFENDSEEKLKGTVEVR 1264
Query: 64 LCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDI 114
+++ + EN DI DR F+L+A+S E+ ++W + +
Sbjct: 1265 TAKEI-----IDNTTKENG--IDIIMADRTFHLIAESPEDASQWFSVLSQV 1308
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 50.1 bits (118), Expect = 7e-06
Identities = 99/462 (21%), Positives = 160/462 (34%), Gaps = 80/462 (17%)
Query: 120 TEEDPVKPP-GSSLQAPADLPLA------INTAPPSTQADSSSATLP-----PPYQL--- 164
T+ PV PP ++ PA LP + + APPS A S TLP PP Q
Sbjct: 312 TKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPS 371
Query: 165 -----INVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPS 219
+ PP L+T+ + P + S + P+ S ++T+ S
Sbjct: 372 MTTPPMQAPPSLQTIPPIQVPHS----LTSPSLQAPPSPLALSSLQATT----------S 417
Query: 220 HKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTE 279
+P + + +Q + PSR S DS P S LP P T
Sbjct: 418 LGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLS-----LPASPPLQTS 472
Query: 280 ADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD 339
+ ++P ++ S++ P P ++ +P + +L S L T P
Sbjct: 473 LSPAVSPLSSP---LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPS-LQTPPA 528
Query: 340 IPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399
P + P+ P++T S P T ++ C + S L +
Sbjct: 529 SLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPS------PLTTPPPE 582
Query: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNP--NSPPR 457
S P+A P+ S L+G + P++P PP+
Sbjct: 583 TPSSIATPPPQAPPALASPPLQGLPS----------------------PPLSPLATPPPQ 620
Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEP- 516
P+Q P +P ++ Q P + +P +PP P A P
Sbjct: 621 APPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 680
Query: 517 --PPVDRNLKPDRKVKPA----PLEIKPLPEWEELQAPVRSP 552
PPV + P + P+ PL++ P P +P +P
Sbjct: 681 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 722
Score = 43.9 bits (102), Expect = 5e-04
Identities = 103/454 (22%), Positives = 157/454 (34%), Gaps = 80/454 (17%)
Query: 124 PVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDY 183
P PP QAP + APPS Q T+PP I VP L + +Q P
Sbjct: 361 PATPPS---QAPPSMTTPPMQAPPSLQ------TIPP----IQVPHSLTSPSLQAPPSPL 407
Query: 184 LLL-INCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIY 242
L + + PT A + T S ++ S PAS+
Sbjct: 408 ALSSLQATTSLGSPT-LQATHSFLTMSPRQTQASLTSPSRPASTPP-------------- 452
Query: 243 DSPPSRAPSASVDSSLYNLPRS--YSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
DSPP +AP +LP S + P VSP S+ ++ S +S Q
Sbjct: 453 DSPPLQAP--------LSLPASPPLQTSLSPAVSPLSSPLT--IHPLQALSSLASHSPQA 502
Query: 301 RHVSISYDIPPTPGNTYQIPRTF--PEGTLGQTSKLDTIPDIPPP--------------- 343
S+ +PP + P + P +L T L+ +P + PP
Sbjct: 503 PLSSLI--MPPLETQSSLAPPSLQTPPASL-TTPPLENLPSLAPPPLQTASAPLTTPHLE 559
Query: 344 RPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQ 403
PP P P ++P + P +T SS P P+ +++ L L S
Sbjct: 560 TPPCPAPCPLQAPPSPLTTP--PPETPSSIATPPPQAPPA----LASPPLQGLPSPPLSP 613
Query: 404 DCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPM--NPNSPPRQHSS 461
P+A P L+ + + + + S + + V + P SPP
Sbjct: 614 LATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP---- 669
Query: 462 SFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDR 521
+ P+Q P +P ++ Q PP P +PP P PPP
Sbjct: 670 --SPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP--- 724
Query: 522 NLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITR 555
+ + PL++ P P +P +P R
Sbjct: 725 --QAPPPLAAPPLQVPPSPPASPPMSPSATPPPR 756
Score = 43.1 bits (100), Expect = 9e-04
Identities = 69/266 (25%), Positives = 95/266 (35%), Gaps = 40/266 (15%)
Query: 117 FNPTEEDPVKPPGSS-LQAPADL---PLAINTAPPSTQADSSSATLPPPYQLINVPPHLE 172
F+P PV P + QAP L PL + +PP++ S SAT PP PP L
Sbjct: 677 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP-----QAPPPLA 731
Query: 173 TLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGM 232
+Q P S P P +A P + P S + M
Sbjct: 732 APPLQVPPSPPASPPMSPSATPPPRVPPLLAA-------------PPLQVPPSPPASLPM 778
Query: 233 NGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSG 292
+ + PP +AP A L LP + P +P S A + +P
Sbjct: 779 SPLAK-------PPPQAPPALATPPLQALPSPPAS--FPGQAPFSPSASLPM----SPLA 825
Query: 293 TSSVETQMRHVSISYDIPPTP--GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHP 350
T + + +PP+P T Q PR P T G + + P + P P P
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP--TPGPDTSVSG-PRLTLALAPGPPP 882
Query: 351 AHDRSPVETCSIPRTASDTDSSYCIP 376
RSP T S P A + S+ P
Sbjct: 883 PPSRSPSSTLSGPDLAGHSSSATSTP 908
Score = 33.9 bits (76), Expect = 0.52
Identities = 102/497 (20%), Positives = 159/497 (31%), Gaps = 73/497 (14%)
Query: 129 GSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLIN 188
G LQ PA L+ + P S+ A S + P P H Q P+ L
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTP----RAPAHPS----QPKPKGLQAL-- 280
Query: 189 CQSKKPEPTRTHADSA------KSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIY 242
+ P+ T D+A S+ T + P + +
Sbjct: 281 ---RPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPL 337
Query: 243 DSP-PSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVET-QM 300
+P P PS S SL LP P PS P ++ Q+
Sbjct: 338 ATPLPLAPPSPSAPPSLQTLPSP------PATPPSQAPPSMTTPPMQAPPSLQTIPPIQV 391
Query: 301 RH--VSISYDIPPTPGNTYQIPRTFPEG--TLGQTSKLDTIPDIPPPRPPKPHPAHDRSP 356
H S S PP+P + T G TL T T+ P+ A SP
Sbjct: 392 PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS-------PRQTQASLTSP 444
Query: 357 VETCSIPRTASDTDSSYCIPTA-----GMSPSRSNTISTVDLNKLRKDASSQDCYDIPRA 411
S P + + +P + +SP+ S S + ++ L+ A
Sbjct: 445 SRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQ-------------A 491
Query: 412 FPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEAN 471
S S S + + + + T S++ L P + +PP ++ S P +
Sbjct: 492 LSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP--PASLTTPPLENLPSLAPPPLQTA 549
Query: 472 YVPMT-----------PGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVD 520
P+T P + PPP ++P PP+ P +A PP
Sbjct: 550 SAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATP--PPQAPPALAS--PPLQG 605
Query: 521 RNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSS 580
P + P + P LQAP P + + ++ P +P +VH +
Sbjct: 606 LPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF 665
Query: 581 DSHDSEENYVPMNPNLS 597
S P +P S
Sbjct: 666 SPPPSPPVQAPFSPPAS 682
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 48.9 bits (115), Expect = 2e-05
Identities = 106/484 (21%), Positives = 164/484 (33%), Gaps = 79/484 (16%)
Query: 194 PEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSAS 253
P+P H S+ T S + +D + S + SS K G G + S++
Sbjct: 402 PQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSS--KGGSEG-------------QPESST 446
Query: 254 VDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISY--DIPP 311
+S+ P+ S P ++ +D T S SS + R VS+ PP
Sbjct: 447 ASNSVVPPPQGGSGRGSPSGGSTAEASD-------TLSIRSSGQLSGRSVSLRKLKRPPP 499
Query: 312 TPGNTYQIPR---TFPEGTLGQTSKLDTIPDIPPPRPPK-------------PHPAHD-- 353
P T+ + + P+G LG K + PRPP P+PA+
Sbjct: 500 PPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWV 559
Query: 354 ------------RSPVETCSIPRTASDTDSSYCIPTAGM-----SPSRSNTISTVDLNKL 396
RSP T S S + +P G+ SP ++ + L
Sbjct: 560 PGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSL 619
Query: 397 RKDASSQD------CYDIPRAFPSDRSSS--LEGFHNHFKVKNVLTVGSVSSEELDENYV 448
R +S C PSDRS L + F + V + S +
Sbjct: 620 RSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRS 679
Query: 449 PMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRP 508
P NP +P + P+ + P +P T + +Q P P PP
Sbjct: 680 P-NPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYH 738
Query: 509 VPVADCEPPPVDRNLKPDRKVKPAPLE-------IKPLPEWEELQAPVRSPITRSFARDS 561
P + P V + PL+ P PE ++L P +F +
Sbjct: 739 PPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVA 798
Query: 562 SRFPMSP--RPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDG--GSSPMI 617
S P P P+ V S +SS S + + P +P+ P ++S G P
Sbjct: 799 SPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQK 858
Query: 618 KPKG 621
+P G
Sbjct: 859 EPVG 862
Score = 36.2 bits (82), Expect = 0.11
Identities = 95/425 (22%), Positives = 135/425 (31%), Gaps = 103/425 (24%)
Query: 119 PTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINV------PPHLE 172
P++ P +L APA +P ++T S Q+ + T P Q V PP
Sbjct: 674 PSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSP 733
Query: 173 TLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGM 232
P +KKPE A SA T+ E + N P PA +
Sbjct: 734 PPSYHPPPP--------PTKKPEVV-VEAPSASETAEEPLQDPNWPPPPPPAPEE----- 779
Query: 233 NGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSG 292
Q + D PP SV SP G + ++P+
Sbjct: 780 ----QDLSMADFPPPEEAFFSV------------------ASPEPAGPSGSPELVSSPAA 817
Query: 293 TSSVETQMR-HVSISYDIPPTPGNTYQIPRTFPEGTL-GQTSKLDTIPDIPPPRPPKPHP 350
+SS T ++ S D PP P P P + G +KL + + P
Sbjct: 818 SSSSATALQIQPPGSPDPPPAP------PAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871
Query: 351 AHDRSPVETCSIPRTA--SDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDI 408
+P+ T S+ + + PT + PS LR+ S
Sbjct: 872 EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQ-------KPLRRALSG------ 918
Query: 409 PRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQ 468
RA P SS G H ++K S E PN PP P
Sbjct: 919 -RASPVPAPSS--GLHAAVRLK-------ACSLAASEGLSSAQPNGPPEAEPRPPQSPAS 968
Query: 469 EANYV------------PMTPGT---------FDFSSFGMQVPPPAHMGFRSSPKTPPRR 507
A+++ P++P T + S Q PP A PK P+
Sbjct: 969 TASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQA-------PKKSPKA 1021
Query: 508 PVPVA 512
P PVA
Sbjct: 1022 PPPVA 1026
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 5 EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
E C G+L K + K WK+RWFV + T YY + H K +I
Sbjct: 1143 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1193
Query: 65 CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
++V N + N + F + T DRI+Y+VA S E M W+ I
Sbjct: 1194 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 5 EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
E C G+L K + K WK+RWFV + T YY + H K +I
Sbjct: 1143 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1193
Query: 65 CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
++V N + N + F + T DRI+Y+VA S E M W+ I
Sbjct: 1194 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 5 EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
E C G+L K + K WK+RWFV + T YY + H K +I
Sbjct: 1127 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1177
Query: 65 CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
++V N + N + F + T DRI+Y+VA S E M W+ I
Sbjct: 1178 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 5 EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
E C G+L K + K WK+RWFV + T YY + H K +I
Sbjct: 1100 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1150
Query: 65 CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
++V N + N + F + T DRI+Y+VA S E M W+ I
Sbjct: 1151 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198
>gi|156616273 pleckstrin [Homo sapiens]
Length = 350
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 4 GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
G ++ G L K +K WK R F+LR DP L YY A+ P+ I L
Sbjct: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293
Query: 64 LCQQVDAGLTFNKKEFENSYIFDINTIDRI-FYLVADSEEEMNKWVRCI 111
C N ++ E +F+I T D + ++L A + +E +W+R I
Sbjct: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342
>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
Length = 1242
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 10 GWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKND-----HAKKPIRIIDLNL 64
G+LRK P+ KR+ FVLR+ G P LEYY+N+ + P R I L
Sbjct: 17 GYLRK--PKSMHKRF------FVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLES 68
Query: 65 CQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDI 114
C ++ + + +N ++ + T D F + ADSE E + W + + +
Sbjct: 69 CFNIN-----KRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQL 113
>gi|38683860 insulin receptor substrate 2 [Homo sapiens]
Length = 1338
Score = 47.0 bits (110), Expect = 6e-05
Identities = 39/151 (25%), Positives = 65/151 (43%), Gaps = 24/151 (15%)
Query: 28 RRWFVLRSGRLTGD-----------PDVLEYYKNDH-----AKKPIRIIDLNLCQQVDAG 71
+R+FVLR GD P LEYY+++ A P R+I L+ C
Sbjct: 45 KRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCC------ 98
Query: 72 LTFNKK-EFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGS 130
L NK+ + ++ Y+ + T D F + A++E+E W R + D+ P +
Sbjct: 99 LNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAA 158
Query: 131 -SLQAPADLPLAINTAPPSTQADSSSATLPP 160
+ A LP A+ + + A+ S + P
Sbjct: 159 PAASCSASLPGALGGSAGAAGAEDSYGLVAP 189
Score = 30.0 bits (66), Expect = 7.5
Identities = 87/428 (20%), Positives = 140/428 (32%), Gaps = 96/428 (22%)
Query: 246 PSRAPSASVDSSLYN-LPRSYSHDVLPKVSPSSTEADGELYVF-NTPSGTSSVETQMR-- 301
P P V Y+ LPRSY +P + D + YV ++P G E ++
Sbjct: 790 PGGEPLRGVPGCCYSSLPRSYK-------APYTCGGDSDQYVLMSSPVGRILEEERLEPQ 842
Query: 302 ------HVSISYDIPPTPGNTYQIPRTF------PEGTLGQTSK--------LDTIPDIP 341
+ ++ PT +P PEG LGQ + L+ +P +P
Sbjct: 843 ATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLP 902
Query: 342 P----PRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLR 397
P PP+P +SP E +I + P A +SP +++ +
Sbjct: 903 SMHEYPLPPEP-----KSPGEYINI---------DFGEPGARLSPPAPPLLASAASSSSL 948
Query: 398 KDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPR 457
ASS S S G + + ++ L+ ++ P P+ P
Sbjct: 949 LSASSP---------ASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPV 999
Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRP--VPVADCE 515
P + Y P+ P S +Q PPP +P R P VA +
Sbjct: 1000 GSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPP-----PAPGELYRLPPASAVATAQ 1054
Query: 516 PPPVDRNLKPD--------------RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDS 561
P +L D P P+ P PE + +P S
Sbjct: 1055 GPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQV 1114
Query: 562 S---RFPMSPRPDSVHSTTS-------------SSDSHDSEENYVPMNPNLSSEDPNLFG 605
S F + +P H SS++ S P++P+ + +P
Sbjct: 1115 SGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSF-AHNPKRHN 1173
Query: 606 SNSLDGGS 613
S S++ S
Sbjct: 1174 SASVENVS 1181
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 21/123 (17%)
Query: 9 SGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIRIIDLNLCQ 66
SG+L K + K +WKRRWFVL+ G L YYK +D +KP I+L+
Sbjct: 707 SGYLLKMSGKVK----SWKRRWFVLKGGELL-------YYKSPSDVIRKPQGHIELSASC 755
Query: 67 QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK 126
+ G +N + T +YL ADS + +W++ + ++ ++
Sbjct: 756 SILRG--------DNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQ 807
Query: 127 PPG 129
P G
Sbjct: 808 PEG 810
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 47.0 bits (110), Expect = 6e-05
Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%)
Query: 2 SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
+G ++ SG+ K +K +WKRR+F L D + Y+K + ++P+R I
Sbjct: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243
Query: 62 LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109
L + L + +F+I T R FY+ ADS E+M+ W++
Sbjct: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 46.2 bits (108), Expect = 1e-04
Identities = 110/437 (25%), Positives = 153/437 (35%), Gaps = 75/437 (17%)
Query: 246 PSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSI 305
PSR S+S S D LP+ +PS G SGT S RH S+
Sbjct: 1414 PSRERSSSASSPEMK-------DGLPR-TPSRRSRSGSSPGLRDGSGTPS-----RH-SL 1459
Query: 306 SYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRT 365
S P IPRT G S+ D+ P+ P P P P RSP +
Sbjct: 1460 SGSSP----GMKDIPRTPSRGR----SECDSSPE-PKALPQTPRP-RSRSP--------S 1501
Query: 366 ASDTDSSYCIPTAGMSPSRSN----TISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLE 421
+ + ++ P S S S+ T++ L + + SSQ+ P A P +RS S
Sbjct: 1502 SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDS 1561
Query: 422 GFHNHFKVKNVL--TVGSVSSEELDEN--------------YVPMNPNSPPRQHSSSFTE 465
+ K + L S SS E+D V P + PR S S +
Sbjct: 1562 SPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSS 1621
Query: 466 PIQEANYVPMTP--GTFDFSSFGMQVPPPAHMGFRSSPKTPPR----RPVPVADCEPPPV 519
P +A P SS G P SSP+ PP+ R + EP
Sbjct: 1622 PEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTK 1681
Query: 520 DRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSS 579
R R + +P + ++ SP TRS R R SP SV S +
Sbjct: 1682 SRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRS--RTPPRHRRSP---SVSSPEPA 1736
Query: 580 SDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTP 639
S S +P + G SP KP+G ++ K+
Sbjct: 1737 EKSRSSRRRRSASSPRTKTTSRR---------GRSPSPKPRGLQRSRSRS---RREKTRT 1784
Query: 640 PRKQKSSGSGSSVADER 656
R++ SGS S + R
Sbjct: 1785 TRRRDRSGSSQSTSRRR 1801
Score = 45.8 bits (107), Expect = 1e-04
Identities = 110/515 (21%), Positives = 177/515 (34%), Gaps = 47/515 (9%)
Query: 114 ICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLET 173
+ G +P + + P ++ + P A + PP SSS PPP Q P
Sbjct: 779 LSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSS---PPPKQKSKTPSRQSH 835
Query: 174 LGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMN 233
P+ + ++ T A+ T C ++ P + + + S+H +
Sbjct: 836 SSSSPHPK---VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCS 892
Query: 234 GFFQQQMIYDSPPSRAPSASVDS----SLYNLPRSYSHDVLPKVSPSSTEADGELYVFNT 289
G ++ +PP ++PS S PR SH SPS + +
Sbjct: 893 GSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRS 952
Query: 290 PSGTSSVETQM--RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTI----PDIPPP 343
S S+VE+++ R+ P T PR G++ K+ P +
Sbjct: 953 VSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGS 1012
Query: 344 RPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQ 403
+ P P S V++C S C +P + L + +S
Sbjct: 1013 KSPCPQEKSKDSLVQSC-------PGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSP 1065
Query: 404 DCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVG-SVSSEELDENYVPMNPNSPPRQHSSS 462
D + + P R S E K + G S SS + E + SP RQ
Sbjct: 1066 D-HRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTE----LASRSPIRQDRGE 1120
Query: 463 FT-EPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDR 521
F+ P+ ++ P SS V + +G + + + PP D
Sbjct: 1121 FSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMAL----PPQEDA 1176
Query: 522 NLKPDR-KVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHST--TS 578
P R K K +P ++ PE + V R+ R+ S SP +S TS
Sbjct: 1177 TASPPRQKDKFSPFPVQDRPE----SSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTS 1232
Query: 579 SSDS------HDSEENYVPMNPNLSSEDPNLFGSN 607
S D SEE + +LSSE + SN
Sbjct: 1233 SQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSN 1267
Score = 33.1 bits (74), Expect = 0.89
Identities = 82/354 (23%), Positives = 123/354 (34%), Gaps = 47/354 (13%)
Query: 345 PPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQD 404
PP A R+P S R S+ +PS S+ + L A Q
Sbjct: 2399 PPLLDRARSRTPPSAPSQSRMTSER-----------APSPSSRMGQAPSQSLLPPAQDQP 2447
Query: 405 CYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVS---SEELDENYVPMNPNSPPRQHSS 461
+P AF SD+S L L+ G+V+ S D N + P +P HS
Sbjct: 2448 RSPVPSAF-SDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVP-APGVPHSD 2505
Query: 462 SFTEPIQEANYVP-----MTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEP 516
P P + P SS + SS + +D E
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565
Query: 517 P--PVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVH 574
PV + R P P + + E + P + R + SS S S
Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVREGRPPE-PTPAKRKRRSSSSSSSSSSSSSSSSSS 2624
Query: 575 STTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDS 634
S++SSS S S + + + SS P G +L +SP P G++
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGER----------- 2673
Query: 635 GKSTPPRKQKSSGSGSSVADER-VDYVVVDQQKTLALKSTREAWTDGRQSTESE 687
+S PRK S+ D R + Y V++++ S R+ +QS+ SE
Sbjct: 2674 -RSRSPRKPI-----DSLRDSRSLSYSPVERRRPSPQPSPRD-----QQSSSSE 2716
Score = 31.6 bits (70), Expect = 2.6
Identities = 46/225 (20%), Positives = 80/225 (35%), Gaps = 17/225 (7%)
Query: 436 GSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHM 495
G S++ + + P +P R+ SSS + P + + +P TP S +
Sbjct: 1395 GMSSNQSISSPVLDAVPRTPSRERSSSASSP-EMKDGLPRTPSRRSRSG--------SSP 1445
Query: 496 GFRSSPKTPPRRPVP-----VADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVR 550
G R TP R + + D P + D +P L P P +P
Sbjct: 1446 GLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPEL 1505
Query: 551 SPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLD 610
+ + R+ S S +V T S + + P+ S ++ + S+S
Sbjct: 1506 NNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERS--ESDSSP 1563
Query: 611 GGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADE 655
+ P + ++DS PR+ + SGS V D+
Sbjct: 1564 DSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-SGSSPEVKDK 1607
Score = 30.4 bits (67), Expect = 5.8
Identities = 40/171 (23%), Positives = 67/171 (39%), Gaps = 22/171 (12%)
Query: 449 PMNPNSPPRQHSSSFTEPIQEANYVPMT--PGTFDFSSFGMQVPPPAHM-GFRSSPKTPP 505
P +P + +Q SS + + ++ T + + SS G + P P + R P
Sbjct: 321 PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQP 380
Query: 506 RRPVPVADCEP--PPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSR 563
P++ EP PP + + DR +P + LP+ ++ SP +R +S
Sbjct: 381 LATTPLSQ-EPVNPPSEASPTRDRSPPKSP---EKLPQSSSSESSPPSPQPTKVSRHASS 436
Query: 564 FPMSPRP--------DSVHSTTSSSDSH-----DSEENYVPMNPNLSSEDP 601
P SP+P + S TS + SH D ++ P S P
Sbjct: 437 SPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSP 487
>gi|116284392 mucin 2 precursor [Homo sapiens]
Length = 5179
Score = 45.4 bits (106), Expect = 2e-04
Identities = 66/285 (23%), Positives = 92/285 (32%), Gaps = 40/285 (14%)
Query: 118 NPTEEDPVKPPGSSLQAPADL----PLAINTAPPSTQADSSSATLP--PPYQLINVPPHL 171
+P P+ PP S+ P P T PP T S T P PP +PP
Sbjct: 1501 SPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP-- 1558
Query: 172 ETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHG 231
T P + P PT T + +T S P P ++ S
Sbjct: 1559 -TTTPSPPPTT--------TTTPPPTTTPSPPTTTTPSPPTITTTTPP---PTTTPSPPT 1606
Query: 232 MNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVS-----------PSSTEA 280
SPP+ P + +S LP + + P + P++T
Sbjct: 1607 TTTTTPPPTTTPSPPTTTP-ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTP 1665
Query: 281 DGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEG--TLGQTSKLDTIP 338
+ TP T++ + + + PPT T P T P T T T P
Sbjct: 1666 SPPITTTTTPPPTTTPSSPIT----TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTP 1721
Query: 339 DIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPS 383
PP P P SP T T T +S + T + PS
Sbjct: 1722 SPPPTTMTTPSPTTTPSPPTTTM--TTLPPTTTSSPLTTTPLPPS 1764
Score = 36.6 bits (83), Expect = 0.080
Identities = 98/503 (19%), Positives = 143/503 (28%), Gaps = 92/503 (18%)
Query: 125 VKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYL 184
+ P P+ P + T PP+T + T P P + T
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITT----------- 1444
Query: 185 LLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDS 244
+ P PT T + +T++ P P S
Sbjct: 1445 ------TTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTP--------------------S 1478
Query: 245 PPSRAPSASVDSSLYNLPRSYSH--DVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRH 302
PP+ PS ++ P + P P+ST L TPS ++ T
Sbjct: 1479 PPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTT---LPPTTTPSPPTTTTT---- 1531
Query: 303 VSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSI 362
P P T P T P T+ L PP P P P +P T +
Sbjct: 1532 -------TPPPTTTPSPPTTTPITPPTSTTTL------PPTTTPSPPPTTTTTPPPTTTP 1578
Query: 363 PRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEG 422
+ T S I T P+ + + T + P P+ ++
Sbjct: 1579 SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTT---- 1634
Query: 423 FHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDF 482
L + S P +P +++ + PI P P T
Sbjct: 1635 ----------LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPP--PTTTPS 1682
Query: 483 SSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEW 542
S PP SP T P P+ + P P+P P P
Sbjct: 1683 SPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSP-TTTPSP-- 1739
Query: 543 EELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPN 602
P + T SS +P P S+ T S S P P + P
Sbjct: 1740 -----PTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPFS-----TTTPTTPCV----PL 1785
Query: 603 LFGSNSLDGGSSPMIKPKGDKQV 625
+ LD G KP GD ++
Sbjct: 1786 CNWTGWLDSGKPNFHKPGGDTEL 1808
Score = 32.3 bits (72), Expect = 1.5
Identities = 54/276 (19%), Positives = 84/276 (30%), Gaps = 29/276 (10%)
Query: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQED 179
T P P + P +PP+T + T PP PP T
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTT---PSP 1502
Query: 180 PQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQ 239
P + + PT T + +T++ P P + +
Sbjct: 1503 PTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS---------- 1552
Query: 240 MIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQ 299
PP+ PS ++ P + P++T TP T++
Sbjct: 1553 -TTTLPPTTTPSPPPTTTTTPPPTT------TPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605
Query: 300 MRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKL--DTIPDIPPPRPPKPHPAHDRSP- 356
+ P P T P T P T+ L T P PP P P SP
Sbjct: 1606 TTTTT-----TPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPP 1660
Query: 357 -VETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTV 391
T S P T + T P++ ++ + S +T+
Sbjct: 1661 TTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTM 1696
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 10/106 (9%)
Query: 7 VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
VC G+L K + K +WK+RWFV + T L YY + H K +I +
Sbjct: 1211 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1261
Query: 67 QVDAG-LTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
+V L K + F + T DR++Y+VA S E M W+ I
Sbjct: 1262 EVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307
>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
Length = 1970
Score = 45.1 bits (105), Expect = 2e-04
Identities = 91/428 (21%), Positives = 139/428 (32%), Gaps = 27/428 (6%)
Query: 249 APSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYD 308
+PSA+ D+S ++ YS P + Y+ PS ++ S +Y+
Sbjct: 1547 SPSAASDASGFS--PGYSPAWSPTPGSPGSPGPSSPYI---PSPGGAMSPSYSPTSPAYE 1601
Query: 309 IPPTPGNTYQIPR---TFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRT 365
G T Q P T P + S T P+ P P + SP P +
Sbjct: 1602 PRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTS 1661
Query: 366 AS--DTDSSYCIPTAGM----SPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSS 419
S T SY PT+ SPS S T + +S ++ S
Sbjct: 1662 PSYSPTSPSYS-PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSY 1720
Query: 420 LEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPI---QEANYVPMT 476
++ + S S NY P +PN P S S T P NY P +
Sbjct: 1721 SPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTS 1780
Query: 477 PG----TFDFSSFGMQVPPPAHMGFRSSPKTPPRRP--VPVADCEPPPVDRNLKPDRKVK 530
P + +S P + SSP+ P+ P P + P K
Sbjct: 1781 PNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYT 1840
Query: 531 PAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF-PMSP--RPDSVHSTTSSSDSHDSEE 587
P P +P SP + ++ S ++ P SP P + + +S +
Sbjct: 1841 PTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSP 1900
Query: 588 NYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSG 647
Y P +P S P ++ +SP P K Y ++P S
Sbjct: 1901 VYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPA 1960
Query: 648 SGSSVADE 655
+DE
Sbjct: 1961 ISPDDSDE 1968
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/220 (25%), Positives = 77/220 (35%), Gaps = 51/220 (23%)
Query: 452 PNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPA---HMGFRSSPKTPPRRP 508
P PP + +F A+Y+P +P T + VPPP F + P P P
Sbjct: 808 PPVPPAKKQPAFP-----ASYIPPSPPTPP-----VPVPPPTLPKQQSFCAKPPPSPLSP 857
Query: 509 VP-----VADCEPPPVDRNLKPDRKVKPAPLEIKP--------LPEWEELQAPVRSPITR 555
VP +A PPP + +KP P + P P+W+ PV SP
Sbjct: 858 VPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFP 917
Query: 556 SFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGS-------NS 608
+SS P P V + P P +S P+ GS S
Sbjct: 918 PPPPESSLVFPPPPPSPVPAPP-------------PPPPPTASPTPDKSGSPGKKTSKTS 964
Query: 609 LDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGS 648
GG P P+ + ++ SG P K+ S S
Sbjct: 965 SPGGKKPPPTPQRNSSIK-----SSSGAEHPEPKRPSVDS 999
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/233 (21%), Positives = 78/233 (33%), Gaps = 20/233 (8%)
Query: 119 PTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQE 178
P ++ P P +P P+ + PP+ S PPP L VP ++ + Q
Sbjct: 812 PAKKQPAFPASYIPPSPPTPPVPV--PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQF 869
Query: 179 DPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDN---VPSHKNPASSQSKHGMNGF 235
P + Q KP P S + ++ + VPS P
Sbjct: 870 PPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPP-------- 921
Query: 236 FQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSS 295
+ +++ PP A + P S T + G TP SS
Sbjct: 922 -ESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSS 980
Query: 296 VETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKP 348
+++ + P P + + P G SK +T+P PP PPKP
Sbjct: 981 IKSSS---GAEHPEPKRPSVDSLVSKFTPPAESGSPSK-ETLP--PPAAPPKP 1027
Score = 35.4 bits (80), Expect = 0.18
Identities = 103/465 (22%), Positives = 145/465 (31%), Gaps = 89/465 (19%)
Query: 124 PVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDY 183
P P AP PL I+ TQ + T PPP PP L Q P+
Sbjct: 732 PCAPSLPQFSAPPP-PLKIHQVQHITQV--APPTPPPP------PPIPAPLPPQAPPKPL 782
Query: 184 LLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYD 243
+ + P T+T A + T P+ K PA F I
Sbjct: 783 VTI-----PAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPA-----------FPASYIPP 826
Query: 244 SPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFN------TPSGTSSVE 297
SPP+ P V LP+ S P SP S + + TP S
Sbjct: 827 SPPT--PPVPVPPP--TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP 882
Query: 298 TQMRHVSISYDIPPT------------PGNTYQIPRTFPEGTLG-QTSKLDTIPDIPPPR 344
+ +++ PP P + P PE +L +P PPP
Sbjct: 883 LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPP 942
Query: 345 PPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQD 404
PP P D+S +T+ SP T N K +S +
Sbjct: 943 PPTASPTPDKSGSPGKKTSKTS--------------SPGGKKPPPTPQRNSSIKSSSGAE 988
Query: 405 CYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFT 464
P + S++ + F GS S E L P P P + + S
Sbjct: 989 -------HPEPKRPSVDSLVSKFTPP--AESGSPSKETLPP---PAAPPKPGKLNLSGVN 1036
Query: 465 EP--IQE---ANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPV 519
P +Q+ + P+ G S PP S PP P P + PP+
Sbjct: 1037 LPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPP-------SDSDFPP--PPPETELPLPPI 1087
Query: 520 DRNLKPDRKVKPAPLEIKPLP-EWEELQAPVRSPITRSFARDSSR 563
+ P + P P +W ++ P TR DS+R
Sbjct: 1088 EIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTR 1132
Score = 30.0 bits (66), Expect = 7.5
Identities = 30/129 (23%), Positives = 47/129 (36%), Gaps = 22/129 (17%)
Query: 449 PMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSS--PKTPPR 506
P+ P +PP+ + P P+ + P F +S P +PP
Sbjct: 772 PLPPQAPPKP-LVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPT 830
Query: 507 RPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPM 566
PVPV PP + + K P+PL SP+ + +S+FP
Sbjct: 831 PPVPVP---PPTLPKQQSFCAKPPPSPL----------------SPVPSVVKQIASQFPP 871
Query: 567 SPRPDSVHS 575
P P ++ S
Sbjct: 872 PPTPPAMES 880
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 43.5 bits (101), Expect = 7e-04
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 21/117 (17%)
Query: 7 VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
VC G+L K + K +WK+RWFV + T L YY + H K +I +
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 67 QV--DAGLTFNKKEF----------ENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
+V D + KK F + F + T DR++Y+VA S E M W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 43.5 bits (101), Expect = 7e-04
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 21/117 (17%)
Query: 7 VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
VC G+L K + K +WK+RWFV + T L YY + H K +I +
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308
Query: 67 QV--DAGLTFNKKEF----------ENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
+V D + KK F + F + T DR++Y+VA S E M W+ I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 43.5 bits (101), Expect = 7e-04
Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 39/178 (21%)
Query: 4 GEVVCSGWL--RKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
G C GWL RK+P R W+RRWFVL+ L +Y+ +K +I+
Sbjct: 395 GRPDCDGWLLLRKAPGGFMGPR--WRRRWFVLKG-------HTLYWYRQPQDEKAEGLIN 445
Query: 62 LNLCQQVDAGLTFNKKEFENSYIFDI-NTIDRIFYLVADSEEEMNKWVR----CIC---- 112
++ +++G KK Y+F + + + + F AD+ +++ WVR CI
Sbjct: 446 VS-NYSLESGHDQKKK-----YVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQS 499
Query: 113 ---------DICGFNPTEEDPVKPPGSSLQAP----ADLPLAINTAPPSTQADSSSAT 157
+ C EDP GS +P A PL +T+P +T S T
Sbjct: 500 PGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRT 557
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,545,444
Number of Sequences: 37866
Number of extensions: 2050361
Number of successful extensions: 11410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 488
Number of HSP's that attempted gapping in prelim test: 9022
Number of HSP's gapped (non-prelim): 2561
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.