Search of human proteins with 46370071

Search of human proteins with 46370071

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
sapiens]
         (724 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa...  1491   0.0  
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa...  1415   0.0  
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa...   415   e-116
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap...   343   2e-94
gi|126091130 Gab3 protein isoform 1 [Homo sapiens]                    229   9e-60
gi|18079323 Gab3 protein isoform 2 [Homo sapiens]                     228   2e-59
gi|83716021 GRB2-associated binding protein family, member 4 [Ho...   169   1e-41
gi|50234893 pleckstrin homology domain containing, family A (pho...    56   1e-07
gi|31377720 pleckstrin homology domain containing, family A (pho...    56   1e-07
gi|55741447 pleckstrin homology domain containing, family H (wit...    54   7e-07
gi|154354979 myosin X [Homo sapiens]                                   53   1e-06
gi|197313732 pleckstrin homology-like domain, family B, member 2...    49   2e-05
gi|197313730 pleckstrin homology-like domain, family B, member 2...    49   2e-05
gi|197313728 pleckstrin homology-like domain, family B, member 2...    49   2e-05
gi|21955172 pleckstrin homology-like domain, family B, member 2 ...    49   2e-05
gi|156616273 pleckstrin [Homo sapiens]                                 48   3e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        48   4e-05
gi|5031805 insulin receptor substrate 1 [Homo sapiens]                 47   5e-05
gi|38683860 insulin receptor substrate 2 [Homo sapiens]                47   6e-05
gi|217416392 pleckstrin homology domain containing, family H (wi...    47   6e-05
gi|154146216 pleckstrin homology domain containing, family A (ph...    47   6e-05
gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]              47   8e-05
gi|83367077 mucin 16 [Homo sapiens]                                    46   1e-04
gi|116284392 mucin 2 precursor [Homo sapiens]                          45   2e-04
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    45   2e-04
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             45   2e-04
gi|221219026 pleckstrin homology-like domain, family B, member 1...    45   2e-04
gi|221219024 pleckstrin homology-like domain, family B, member 1...    44   7e-04
gi|38424073 pleckstrin homology-like domain, family B, member 1 ...    44   7e-04
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    44   7e-04

>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
           sapiens]
          Length = 724

 Score = 1491 bits (3859), Expect = 0.0
 Identities = 724/724 (100%), Positives = 724/724 (100%)

Query: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
           MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
Sbjct: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60

Query: 61  DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
           DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
Sbjct: 61  DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120

Query: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
           EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
Sbjct: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180

Query: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
           QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
Sbjct: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240

Query: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
           IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
Sbjct: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300

Query: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
           RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
Sbjct: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360

Query: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
           SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
Sbjct: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420

Query: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
           EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
Sbjct: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480

Query: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH 540
           DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
Sbjct: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH 540

Query: 541 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 600
           GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
Sbjct: 541 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 600

Query: 601 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 660
           DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
Sbjct: 601 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 660

Query: 661 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 720
           DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
Sbjct: 661 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 720

Query: 721 KSVK 724
           KSVK
Sbjct: 721 KSVK 724


>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
           sapiens]
          Length = 694

 Score = 1415 bits (3663), Expect = 0.0
 Identities = 694/724 (95%), Positives = 694/724 (95%), Gaps = 30/724 (4%)

Query: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
           MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
Sbjct: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60

Query: 61  DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120
           DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
Sbjct: 61  DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT 120

Query: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180
           EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
Sbjct: 121 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP 180

Query: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240
           QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
Sbjct: 181 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM 240

Query: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300
           IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
Sbjct: 241 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM 300

Query: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360
           RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
Sbjct: 301 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC 360

Query: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420
           SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
Sbjct: 361 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL 420

Query: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480
           EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
Sbjct: 421 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF 480

Query: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH 540
           DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD              
Sbjct: 481 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD-------------- 526

Query: 541 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 600
                           RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
Sbjct: 527 ----------------RKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP 570

Query: 601 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 660
           DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
Sbjct: 571 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL 630

Query: 661 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 720
           DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
Sbjct: 631 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA 690

Query: 721 KSVK 724
           KSVK
Sbjct: 691 KSVK 694


>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
           sapiens]
          Length = 676

 Score =  415 bits (1066), Expect = e-116
 Identities = 286/749 (38%), Positives = 391/749 (52%), Gaps = 107/749 (14%)

Query: 3   GGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDL 62
           GG+VVC+GWLRKSPPEKKL+RYAWK+RWF+LRSGR++GDPDVLEYYKNDH+KKP+RII+L
Sbjct: 4   GGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL 63

Query: 63  NLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEE 122
           N C+QVDAGLTFNKKE ++S++FDI T +R FYLVA++EE+MNKWV+ IC ICGFN  EE
Sbjct: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123

Query: 123 --DPVKPPGSSLQAPADLPLAIN-----------TAPPSTQADSSSATLPPPYQLINVPP 169
             D ++   S+   P   P  ++           ++ PS  +  +  T  PP     V  
Sbjct: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPP-----VSN 178

Query: 170 HLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSK 229
           H++       PQ+YL L  C S++ E  R+ + S  + +S    +D         +    
Sbjct: 179 HMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238

Query: 230 HGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGE-LYVFN 288
           +G++G  Q    Y  P     +     S Y+LPRS +     K S + +E D E +Y F 
Sbjct: 239 NGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFK 296

Query: 289 TPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD------IPP 342
           TPS T   E     V  + D+P TP + YQIPRTF   TL +     T+         PP
Sbjct: 297 TPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF---TLDKNHNAMTVATPGDSAIAPP 352

Query: 343 PRPPKPHPAHD---RSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399
           PRPPKP  A      SP +   I   +    ++  IP       R NT+  +D ++L + 
Sbjct: 353 PRPPKPSQAETPRWGSPQQRPPISENSRSVAAT--IP-------RRNTLPAMDNSRLHR- 402

Query: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNVLTVGSVSSEELDENYVPMNPNSPPR 457
           ASS + Y+ P+        S E   +     +   + VG   S   ++NYVPMNP S   
Sbjct: 403 ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTL 462

Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
                  +  Q   Y+PM+PG   F S          +G+ S+     R P   ++ +PP
Sbjct: 463 LAMERAGDNSQSV-YIPMSPGAHHFDS----------LGYPSTTLPVHRGPSRGSEIQPP 511

Query: 518 PVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQA 577
           PV+RNLKPD                              RK KP PL+++     +EL  
Sbjct: 512 PVNRNLKPD------------------------------RKAKPTPLDLRNNTVIDEL-- 539

Query: 578 PVRSPITRSFARDSSRFPMSP----RPDSVHSTTSSSDSHDSEENYVPM-NPNLSSEDPN 632
           P +SPIT+S++R +  F  S     RP S  S T S+DS DSEENYVPM NP  +S  P+
Sbjct: 540 PFKSPITKSWSRANHTFNSSSSQYCRPISTQSIT-STDSGDSEENYVPMQNPVSASPVPS 598

Query: 633 LFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVV 692
                   G +SP  K K    V+YL LD      +P RK  +S   S  +DE+VDYV V
Sbjct: 599 --------GTNSPAPK-KSTGSVDYLALDFQPSSPSPHRKPSTS---SVTSDEKVDYVQV 646

Query: 693 DQQKTLALKSTREAWTDGRQSTESETPAK 721
           D++KT AL++T + WTD RQS+E    AK
Sbjct: 647 DKEKTQALQNTMQEWTDVRQSSEPSKGAK 675


>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
           sapiens]
          Length = 638

 Score =  343 bits (881), Expect = 2e-94
 Identities = 256/714 (35%), Positives = 356/714 (49%), Gaps = 107/714 (14%)

Query: 38  LTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLV 97
           ++GDPDVLEYYKNDH+KKP+RII+LN C+QVDAGLTFNKKE ++S++FDI T +R FYLV
Sbjct: 1   MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLV 60

Query: 98  ADSEEEMNKWVRCICDICGFNPTEE--DPVKPPGSSLQAPADLPLAIN-----------T 144
           A++EE+MNKWV+ IC ICGFN  EE  D ++   S+   P   P  ++           +
Sbjct: 61  AETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKS 120

Query: 145 APPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSA 204
           + PS  +  +  T  PP     V  H++       PQ+YL L  C S++ E  R+ + S 
Sbjct: 121 SAPSHSSQPTLFTFEPP-----VSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQ 175

Query: 205 KSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRS 264
            + +S    +D         +    +G++G  Q    Y  P     +     S Y+LPRS
Sbjct: 176 GTRASFLMRSDTAVQKLAQGNGHCVNGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRS 233

Query: 265 YSHDVLPKVSPSSTEADGE-LYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTF 323
            +     K S + +E D E +Y F TPS T   E     V  + D+P TP + YQIPRTF
Sbjct: 234 LASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF 292

Query: 324 PEGTLGQTSKLDTIPD------IPPPRPPKPHPAHD---RSPVETCSIPRTASDTDSSYC 374
              TL +     T+         PPPRPPKP  A      SP +   I   +    ++  
Sbjct: 293 ---TLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAAT-- 347

Query: 375 IPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNV 432
           IP       R NT+  +D ++L + ASS + Y+ P+        S E   +     +   
Sbjct: 348 IP-------RRNTLPAMDNSRLHR-ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGK 399

Query: 433 LTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPP 492
           + VG   S   ++NYVPMNP S          +  Q   Y+PM+PG   F S        
Sbjct: 400 MIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSV-YIPMSPGAHHFDS-------- 450

Query: 493 AHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGD 552
             +G+ S+     R P   ++ +PPPV+RNLKPD                          
Sbjct: 451 --LGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPD-------------------------- 482

Query: 553 FATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSP----RPDSVHSTTS 608
               RK KP PL+++     +EL  P +SPIT+S++R +  F  S     RP S  S T 
Sbjct: 483 ----RKAKPTPLDLRNNTVIDEL--PFKSPITKSWSRANHTFNSSSSQYCRPISTQSIT- 535

Query: 609 SSDSHDSEENYVPM-NPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKS 667
           S+DS DSEENYVPM NP  +S  P+        G +SP  K K    V+YL LD      
Sbjct: 536 STDSGDSEENYVPMQNPVSASPVPS--------GTNSPAPK-KSTGSVDYLALDFQPSSP 586

Query: 668 TPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAK 721
           +P RK  +S   S  +DE+VDYV VD++KT AL++T + WTD RQS+E    AK
Sbjct: 587 SPHRKPSTS---SVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAK 637


>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
          Length = 587

 Score =  229 bits (583), Expect = 9e-60
 Identities = 210/729 (28%), Positives = 316/729 (43%), Gaps = 160/729 (21%)

Query: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
           MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1   MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60

Query: 61  DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
           DL+ C      G +F +KEF+N+++F + T  R FYLVA +E+EM  WV  I  +C    
Sbjct: 61  DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120

Query: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQE- 178
            E+       S    P+   L  ++A     A ++S++LP      N     ET    E 
Sbjct: 121 LEDGAADSMESLSYTPSS--LQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESEL 178

Query: 179 -DPQDYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------PSHKNPASSQ 227
               DYL+L NC++ +      PTR  + S    S E    D+V      P   +     
Sbjct: 179 LFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHP 238

Query: 228 SKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVF 287
           S HG           + P SR  +A + S   N P                         
Sbjct: 239 SCHGSGA-------QEVPSSRPQAALIWSREINGP------------------------- 266

Query: 288 NTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTIPDIPPPRPP 346
                         H+S S  +  +  +T Q+ +   +G+L   +K LD + + PPPRPP
Sbjct: 267 -----------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIMSNTPPPRPP 313

Query: 347 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY 406
           KP    +R   E          T S    P   + P R +     ++   + D   Q   
Sbjct: 314 KPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLR 365

Query: 407 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP 466
              +    +        +              +S  ++++YVPM+P +     +S     
Sbjct: 366 HRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA----GASGLGPH 409

Query: 467 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD 526
               +Y+PM  G+                   SSP   P  P   A+ EPPPV+R+LKP 
Sbjct: 410 CSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPPPVNRDLKPQ 446

Query: 527 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS 586
           RK                               +P PL+++ L    E  +  R   TR+
Sbjct: 447 RKS------------------------------RPPPLDLRNLSIIREHASLTR---TRT 473

Query: 587 FARDSSRFPMSPRPDSVHSTT--SSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSS 644
                + F +SP  + ++S    ++  S + EE+Y+ M  + +        ++SL  G+ 
Sbjct: 474 VPCSRTSF-LSPERNGINSARFFANPVSREDEESYIEMEEHRT--------ASSLSSGAL 524

Query: 645 PMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTR 704
              K      ++YL LD +S  S  P +QK   S     ++RVDYV VD+QKT AL+ST+
Sbjct: 525 TWTK---KFSLDYLALDFNSA-SPAPMQQKLLLS----EEQRVDYVQVDEQKTQALQSTK 576

Query: 705 EAWTDGRQS 713
           + WTD RQS
Sbjct: 577 QEWTDERQS 585


>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
          Length = 586

 Score =  228 bits (581), Expect = 2e-59
 Identities = 209/738 (28%), Positives = 318/738 (43%), Gaps = 179/738 (24%)

Query: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII 60
           MS G+ VC+GWL KSPPE+KL+RYAW++RWFVLR GR++G+PDVLEYY+N H+ KPIR+I
Sbjct: 1   MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 60

Query: 61  DLNLCQ-QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNP 119
           DL+ C      G +F +KEF+N+++F + T  R FYLVA +E+EM  WV  I  +C    
Sbjct: 61  DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 120

Query: 120 TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVP---PHLETLGI 176
            E+             AD   +++  P S Q  S+S+ L       ++P   P+   +  
Sbjct: 121 LEDG------------ADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVAT 168

Query: 177 QEDPQ--------DYLLLINCQSKKPE----PTRTHADSAKSTSSETDCNDNV------P 218
           +E           DYL+L NC++ +      PTR  + S    S E    D+V      P
Sbjct: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQP 228

Query: 219 SHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSST 278
              +     S HG           + P SR  +A + S   N P                
Sbjct: 229 LPSSHLVHPSCHGSGA-------QEVPSSRPQAALIWSREINGP---------------- 265

Query: 279 EADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK-LDTI 337
                                  H+S S  +  +  +T Q+ +   +G+L   +K LD +
Sbjct: 266 --------------------PRDHLSSSPLLESSLSSTIQVDKN--QGSLPCGAKELDIM 303

Query: 338 PDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLR 397
            + PPPRPPKP    +R   E          T S    P   + P R +     ++   +
Sbjct: 304 SNTPPPRPPKPSHLSERRQEEW--------STHSGSKKPECTLVPRRISLSGLDNMRTWK 355

Query: 398 KDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPR 457
            D   Q      +    +        +              +S  ++++YVPM+P +   
Sbjct: 356 ADVEGQSLRHRDKRLSLNLPCRFSPMY------------PTASASIEDSYVPMSPQA--- 400

Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517
             +S         +Y+PM  G+                   SSP   P  P   A+ EPP
Sbjct: 401 -GASGLGPHCSPDDYIPMNSGSI------------------SSPL--PELP---ANLEPP 436

Query: 518 PVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQA 577
           PV+R+LKP RK                               +P PL+++ L    E  +
Sbjct: 437 PVNRDLKPQRKS------------------------------RPPPLDLRNLSIIREHAS 466

Query: 578 PVRSPITRSFARDSSRFPMSPRPDSVHSTT--SSSDSHDSEENYVPMNPNLSSEDPNLFG 635
             R   TR+     + F +SP  + ++S    ++  S + EE+Y+ M  + +        
Sbjct: 467 LTR---TRTVPCSRTSF-LSPERNGINSARFFANPVSREDEESYIEMEEHRT-------- 514

Query: 636 SNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQ 695
           ++SL  G+    K      ++YL LD +S  S  P +QK   S     ++RVDYV VD+Q
Sbjct: 515 ASSLSSGALTWTK---KFSLDYLALDFNSA-SPAPMQQKLLLS----EEQRVDYVQVDEQ 566

Query: 696 KTLALKSTREAWTDGRQS 713
           KT AL+ST++ WTD RQS
Sbjct: 567 KTQALQSTKQEWTDERQS 584


>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
           sapiens]
          Length = 574

 Score =  169 bits (427), Expect = 1e-41
 Identities = 75/120 (62%), Positives = 95/120 (79%), Gaps = 2/120 (1%)

Query: 4   GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
           G V+ SGWLRKSPPEKKL+ +AW++RWF+LR G+ + DPDVLEYYKND +KKP+R I+LN
Sbjct: 38  GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97

Query: 64  LCQQ--VDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTE 121
           LC+Q  VD  L FNKKE +  Y+FDI T +R FYLVA++ E+MN+WV+ IC ICGF   E
Sbjct: 98  LCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQEE 157



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 60/209 (28%), Positives = 91/209 (43%), Gaps = 57/209 (27%)

Query: 517 PPVDRNLKPDRKGQ-SPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEEL 575
           PPV+R+LKP++K   +P  LR         +++ I +           L  KP       
Sbjct: 418 PPVNRSLKPNQKANPTPPNLR---------NNRVINE-----------LSFKP------- 450

Query: 576 QAPVRSP---ITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPN 632
             PV  P    + +F   SS+ P+S +      + +++DS DS E Y  + PN +S  P 
Sbjct: 451 --PVTEPWSGTSHTFDSSSSQHPISTQ------SITNTDSEDSGERY--LFPNPASAFP- 499

Query: 633 LFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVV 692
                 + GG+S    P+    + Y  LD    K +          GS  + ++VDYV V
Sbjct: 500 ------VSGGTSSSAPPRSTGNIHYAALDFQPSKPS---------IGSVTSGKKVDYVQV 544

Query: 693 DQQKTLALKSTREAWTDGRQSTESETPAK 721
           D +KT AL+ T       RQS+E    AK
Sbjct: 545 DLEKTQALQKTMHEQMCLRQSSEPPRGAK 573


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 30/143 (20%)

Query: 26  WKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL------CQQVDAGLTFNKKEF 79
           WKRR+F L       D + + Y+K++  K+P+R+I L        C+Q D  +  N    
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256

Query: 80  ENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK------PPGSSLQ 133
               +F+I T  R FY+ ADS EEM+ W++    + G    +  P +      PPG S  
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKA---VSGAIVAQRGPGRSASSEHPPGPSES 309

Query: 134 APADLPLAINTAPPSTQADSSSA 156
             A  P    TA   + A  S++
Sbjct: 310 KHAFRPTNAATATSHSTASRSNS 332


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 43/143 (30%), Positives = 66/143 (46%), Gaps = 30/143 (20%)

Query: 26  WKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL------CQQVDAGLTFNKKEF 79
           WKRR+F L       D + + Y+K++  K+P+R+I L        C+Q D  +  N    
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256

Query: 80  ENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK------PPGSSLQ 133
               +F+I T  R FY+ ADS EEM+ W++    + G    +  P +      PPG S  
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKA---VSGAIVAQRGPGRSASSEHPPGPSES 309

Query: 134 APADLPLAINTAPPSTQADSSSA 156
             A  P    TA   + A  S++
Sbjct: 310 KHAFRPTNAATATSHSTASRSNS 332


>gi|55741447 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 21/113 (18%)

Query: 1   MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIR 58
           + G  +  SG+L K   + K     WKRRWFVLR G++        YYK  +D  +KP  
Sbjct: 574 LGGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQIM-------YYKSPSDVIRKPQG 622

Query: 59  IIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
            +DLN   Q+  G        E S  F + +  + +YL ADS   + +W+R +
Sbjct: 623 QVDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIRVL 667


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 32/111 (28%), Positives = 54/111 (48%), Gaps = 15/111 (13%)

Query: 5    EVVCSGWL-RKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
            E +  GWL +K      L R  WK+RWFVLR  +L        Y++ND  +K    +++ 
Sbjct: 1212 EALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLM-------YFENDSEEKLKGTVEVR 1264

Query: 64   LCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDI 114
              +++      +    EN    DI   DR F+L+A+S E+ ++W   +  +
Sbjct: 1265 TAKEI-----IDNTTKENG--IDIIMADRTFHLIAESPEDASQWFSVLSQV 1308


>gi|197313732 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 5    EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
            E  C G+L K   + K     WK+RWFV    + T       YY + H  K   +I    
Sbjct: 1143 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1193

Query: 65   CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
             ++V      N  +  N  + F + T DRI+Y+VA S E M  W+  I
Sbjct: 1194 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241


>gi|197313730 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 5    EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
            E  C G+L K   + K     WK+RWFV    + T       YY + H  K   +I    
Sbjct: 1143 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1193

Query: 65   CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
             ++V      N  +  N  + F + T DRI+Y+VA S E M  W+  I
Sbjct: 1194 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241


>gi|197313728 pleckstrin homology-like domain, family B, member 2
            isoform b [Homo sapiens]
          Length = 1237

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 5    EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
            E  C G+L K   + K     WK+RWFV    + T       YY + H  K   +I    
Sbjct: 1127 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1177

Query: 65   CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
             ++V      N  +  N  + F + T DRI+Y+VA S E M  W+  I
Sbjct: 1178 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225


>gi|21955172 pleckstrin homology-like domain, family B, member 2
            isoform c [Homo sapiens]
          Length = 1210

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 5    EVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNL 64
            E  C G+L K   + K     WK+RWFV    + T       YY + H  K   +I    
Sbjct: 1100 EKTCRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQA 1150

Query: 65   CQQVDAGLTFNKKEFENSYI-FDINTIDRIFYLVADSEEEMNKWVRCI 111
             ++V      N  +  N  + F + T DRI+Y+VA S E M  W+  I
Sbjct: 1151 IEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198


>gi|156616273 pleckstrin [Homo sapiens]
          Length = 350

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 10/109 (9%)

Query: 4   GEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLN 63
           G ++  G L K    +K     WK R F+LR      DP  L YY    A+ P+  I L 
Sbjct: 243 GVIIKQGCLLKQGHRRK----NWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLR 293

Query: 64  LCQQVDAGLTFNKKEFENSYIFDINTIDRI-FYLVADSEEEMNKWVRCI 111
            C         N ++ E   +F+I T D + ++L A + +E  +W+R I
Sbjct: 294 GCVVTSVESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 128/647 (19%), Positives = 225/647 (34%), Gaps = 104/647 (16%)

Query: 114  ICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLET 173
            + G +P  +   + P    ++ +  P A +  PP     SSS   PPP Q    P     
Sbjct: 779  LSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSS---PPPKQKSKTPSRQSH 835

Query: 174  LGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMN 233
                  P+   +      ++   T   A+    T     C ++ P  +  + + S+H  +
Sbjct: 836  SSSSPHPK---VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCS 892

Query: 234  GFFQQQMIYDSPPSRAPSASVDS----SLYNLPRSYSHDVLPKVSPS------------- 276
            G    ++   +PP ++PS S            PR  SH      SPS             
Sbjct: 893  GSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRS 952

Query: 277  ---STEADGELYVFNTPSGTSSVETQMR---------------HVSISYDIPPTP---GN 315
                +  +  L    + SG+SS +T+++               +  +    PP P   G+
Sbjct: 953  VSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGS 1012

Query: 316  TYQIPRTFPEGTLGQT--SKLDTIPDIPPPRPP----------------KPHPAHDRSPV 357
                P+   + +L Q+    L     +    PP                +  P H RS  
Sbjct: 1013 KSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDH-RSDT 1071

Query: 358  ETCSIPRTASDTDS----SYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFP 413
             +  + ++ S++ S    S   P  G S S S        + +R+D        + ++  
Sbjct: 1072 SSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGM 1131

Query: 414  SDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYV 473
            S   S  +   + +   +  ++   S  E  E+   M   + P Q  ++ + P Q+    
Sbjct: 1132 SPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKM---ALPPQEDATASPPRQKDK-- 1186

Query: 474  PMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPK 533
                    FS F +Q  P + + F+ + +TPPR     A   P   ++N       Q  +
Sbjct: 1187 --------FSPFPVQDRPESSLVFKDTLRTPPRER-SGAGSSPETKEQNSALPTSSQDEE 1237

Query: 534  ILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSR 593
            ++ +     E    Q +   ++  K + +    +  PE EE  A        S   D S+
Sbjct: 1238 LMEVVEKS-EEPAGQILSHLSSELK-EMSTSNFESSPEVEERPAV-------SLTLDQSQ 1288

Query: 594  FPMSPRPDSVHSTTSS-SDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM------ 646
               S     V S  SS    H S E+    N  L     N FGS      S P+      
Sbjct: 1289 SQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRE---NSFGSPLEFRNSGPLGTEMNT 1345

Query: 647  ---IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYV 690
                + K D    +L+  L++  S   ++Q +  SG S ++   D V
Sbjct: 1346 GFSSEVKEDLNGPFLN-QLETDPSLDMKEQSTRSSGHSSSELSPDAV 1391



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 97/384 (25%), Positives = 135/384 (35%), Gaps = 61/384 (15%)

Query: 246  PSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSI 305
            PSR  S+S  S           D LP+ +PS     G        SGT S     RH S+
Sbjct: 1414 PSRERSSSASSPEMK-------DGLPR-TPSRRSRSGSSPGLRDGSGTPS-----RH-SL 1459

Query: 306  SYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRT 365
            S   P        IPRT   G     S+ D+ P+ P   P  P P   RSP        +
Sbjct: 1460 SGSSP----GMKDIPRTPSRGR----SECDSSPE-PKALPQTPRP-RSRSP--------S 1501

Query: 366  ASDTDSSYCIPTAGMSPSRSN----TISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLE 421
            + + ++    P    S S S+    T++   L +  +  SSQ+    P A P +RS S  
Sbjct: 1502 SPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDS 1561

Query: 422  GFHNHFKVKNVL--TVGSVSSEELDEN--------------YVPMNPNSPPRQHSSSFTE 465
               +  K +  L     S SS E+D                 V   P + PR  S S + 
Sbjct: 1562 SPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSS 1621

Query: 466  PIQEANYVPMTP--GTFDFSSFGMQVPPPAHMGFRSSPKTPP--RRPVPVADCEPPPVDR 521
            P  +A      P       SS G    P       SSP+ PP  R     +   P P  +
Sbjct: 1622 PEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTK 1681

Query: 522  NLKPDRKGQSPKILRL-KPHGLERTDSQTIGDFATRRKVKP----APLEIKPLPEWEELQ 576
            +  P R+  S     L +   L R          TR +  P    +P    P P  +   
Sbjct: 1682 SRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRS 1741

Query: 577  APVRSPITRSFARDSSRFPMSPRP 600
            +  R   +    + +SR   SP P
Sbjct: 1742 SRRRRSASSPRTKTTSRRGRSPSP 1765



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 69/274 (25%), Positives = 100/274 (36%), Gaps = 38/274 (13%)

Query: 436  GSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPG--TFDFSSFGMQ---VP 490
            G  S++ +    +   P +P R+ SSS + P +  + +P TP   +   SS G++     
Sbjct: 1395 GMSSNQSISSPVLDAVPRTPSRERSSSASSP-EMKDGLPRTPSRRSRSGSSPGLRDGSGT 1453

Query: 491  PPAHM------GFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGL-- 542
            P  H       G +  P+TP R      D  P P      P  + +SP    L    L  
Sbjct: 1454 PSRHSLSGSSPGMKDIPRTPSRGR-SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTP 1512

Query: 543  --ERTDSQTIGDFAT---------RRKVKPAPLEIKPLPEWEELQAPVRSP----ITRSF 587
              ER+ S++  D  T          R      L++KP    +E      SP     TR+ 
Sbjct: 1513 QRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTP 1572

Query: 588  ARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMI 647
             R  SR   SP  DS  S  S   S       V   P  +    +  GS+     SSP  
Sbjct: 1573 LRQRSRSGSSPEVDS-KSRLSPRRSRSGSSPEVKDKPRAAPRAQS--GSD-----SSPEP 1624

Query: 648  KPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSS 681
            K    + +        S K   P  + SS + SS
Sbjct: 1625 KAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS 1658



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 64/313 (20%), Positives = 108/313 (34%), Gaps = 30/313 (9%)

Query: 341 PPPRPPKPHPAHDRSPVETCSIPRT----ASDTDSSYCIPTAGMSPSRSNTISTVDLNKL 396
           P P+  K     DR      S PR     +S          +     RS T  +   +K 
Sbjct: 183 PTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKD 242

Query: 397 RKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPP 456
           +K   S+     P++  + RS+S +   +    ++     +  +          +P S  
Sbjct: 243 KKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGR 302

Query: 457 R-QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCE 515
           R +  + F+EP   +   P +P T        Q   P     +   +    RP P  +  
Sbjct: 303 RGEGDAPFSEPGTTSTQRPSSPETAT-----KQPSSPYEDKDKDKKEKSATRPSPSPERS 357

Query: 516 P----PPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPE 571
                PP    L  +R G SP+ L   P   E  +  +    A+  + +  P   + LP+
Sbjct: 358 STGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE---ASPTRDRSPPKSPEKLPQ 414

Query: 572 WEELQAPVRSPITRSFARDSSRFPMSPRP--------DSVHSTTSSSDSH-----DSEEN 618
               ++   SP     +R +S  P SP+P        +   S TS + SH     D   +
Sbjct: 415 SSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHS 474

Query: 619 YVPMNPNLSSEDP 631
           + P      S  P
Sbjct: 475 HTPSRRMGRSRSP 487



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 87/378 (23%), Positives = 130/378 (34%), Gaps = 65/378 (17%)

Query: 345  PPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQD 404
            PP    A  R+P    S  R  S+            +PS S+ +       L   A  Q 
Sbjct: 2399 PPLLDRARSRTPPSAPSQSRMTSER-----------APSPSSRMGQAPSQSLLPPAQDQP 2447

Query: 405  CYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVS---SEELDENYVPMNPNSPPRQHSS 461
               +P AF SD+S  L            L+ G+V+   S   D N +   P   P    S
Sbjct: 2448 RSPVPSAF-SDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVP--APGVPHS 2504

Query: 462  SFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDR 521
               EP       P + G    S+     P        SS  +        +         
Sbjct: 2505 DVGEP-------PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSG 2557

Query: 522  NLKPDRKGQSPKILRLKPH-GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVR 580
            +   D +G S   L ++P   L+R  S T       R+ +P        PE      P  
Sbjct: 2558 SSSSDSEGSS---LPVQPEVALKRVPSPTPAPKEAVREGRP--------PE------PTP 2600

Query: 581  SPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLD 640
            +   R  +  SS    S    S  S++SSS S  S  +    + + SS  P   G  +L 
Sbjct: 2601 AKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALP 2660

Query: 641  GGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADER-VDYVVVDQQKTLA 699
              +SP   P G++            +S  PRK        S+ D R + Y  V++++   
Sbjct: 2661 KPASPKKPPPGER------------RSRSPRKPI-----DSLRDSRSLSYSPVERRRPSP 2703

Query: 700  LKSTREAWTDGRQSTESE 717
              S R+     +QS+ SE
Sbjct: 2704 QPSPRD-----QQSSSSE 2716


>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
          Length = 1242

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 18/110 (16%)

Query: 10  GWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKND-----HAKKPIRIIDLNL 64
           G+LRK  P+   KR+      FVLR+    G P  LEYY+N+      +  P R I L  
Sbjct: 17  GYLRK--PKSMHKRF------FVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLES 68

Query: 65  CQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDI 114
           C  ++      + + +N ++  + T D  F + ADSE E + W + +  +
Sbjct: 69  CFNIN-----KRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQL 113


>gi|38683860 insulin receptor substrate 2 [Homo sapiens]
          Length = 1338

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 39/151 (25%), Positives = 65/151 (43%), Gaps = 24/151 (15%)

Query: 28  RRWFVLRSGRLTGD-----------PDVLEYYKNDH-----AKKPIRIIDLNLCQQVDAG 71
           +R+FVLR     GD           P  LEYY+++      A  P R+I L+ C      
Sbjct: 45  KRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCC------ 98

Query: 72  LTFNKK-EFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGS 130
           L  NK+ + ++ Y+  + T D  F + A++E+E   W R + D+            P  +
Sbjct: 99  LNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAA 158

Query: 131 -SLQAPADLPLAINTAPPSTQADSSSATLPP 160
            +    A LP A+  +  +  A+ S   + P
Sbjct: 159 PAASCSASLPGALGGSAGAAGAEDSYGLVAP 189



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 46/195 (23%), Positives = 65/195 (33%), Gaps = 32/195 (16%)

Query: 310  PPTPGNTYQIPRTFPEGTL---GQTSKLDT-----------------IPDIPPPRPPKPH 349
            PP PG  Y++P      T    G  S L +                  P  P   PPKP 
Sbjct: 1035 PPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPE 1094

Query: 350  PAHDRSP---VETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY 406
             A   SP   V+  S+    S  + ++   +    P R   +   D    R+  SS+   
Sbjct: 1095 AARVASPTSGVKRLSLMEQVSGVE-AFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFS 1153

Query: 407  DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNP---NSPPRQHSSSF 463
                  P   S     F ++ K  N  +V +VS  +  E  V + P   + PP       
Sbjct: 1154 STTTVTPVSPS-----FAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQ 1208

Query: 464  TEPIQEANYVPMTPG 478
              P       P TPG
Sbjct: 1209 PAPPLAPQGRPWTPG 1223


>gi|217416392 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 2 [Homo sapiens]
          Length = 1493

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 21/123 (17%)

Query: 9   SGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYK--NDHAKKPIRIIDLNLCQ 66
           SG+L K   + K    +WKRRWFVL+ G L        YYK  +D  +KP   I+L+   
Sbjct: 707 SGYLLKMSGKVK----SWKRRWFVLKGGELL-------YYKSPSDVIRKPQGHIELSASC 755

Query: 67  QVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVK 126
            +  G        +N     + T    +YL ADS   + +W++ + ++          ++
Sbjct: 756 SILRG--------DNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQ 807

Query: 127 PPG 129
           P G
Sbjct: 808 PEG 810


>gi|154146216 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 2 [Homo
           sapiens]
          Length = 425

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 11/108 (10%)

Query: 2   SGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
           +G  ++ SG+  K    +K    +WKRR+F L       D   + Y+K +  ++P+R I 
Sbjct: 195 TGPPLIKSGYCVKQGNVRK----SWKRRFFAL-------DDFTICYFKCEQDREPLRTIF 243

Query: 62  LNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVR 109
           L    +    L  +        +F+I T  R FY+ ADS E+M+ W++
Sbjct: 244 LKDVLKTHECLVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIK 291


>gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]
          Length = 1834

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 52/211 (24%), Positives = 80/211 (37%), Gaps = 37/211 (17%)

Query: 361  SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYD-IPRAFPSDRSSS 419
            S P  AS TD+S+ +P   ++    +  S   ++ LR   + Q      PRA        
Sbjct: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRA-------- 1294

Query: 420  LEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGT 479
                          +VG+    E+ + +  + P +PP Q  SS   P+        +PGT
Sbjct: 1295 --------------SVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPV--------SPGT 1332

Query: 480  FDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKP 539
             D    G + P   H G    P + P  P P++        R LK    G  P  L   P
Sbjct: 1333 SDGRRQGHRSPSRPHPG--GHPHSSPLAPHPISGDRAHFSRRFLKHSPPG--PSFLNQTP 1388

Query: 540  HG--LERTDSQTIGDFATRRKVKPAPLEIKP 568
             G  +E  DS    + A+ +  +  PL+  P
Sbjct: 1389 AGEVVEVGDSDDEQEVASHQANRSPPLDSDP 1419


>gi|83367077 mucin 16 [Homo sapiens]
          Length = 14507

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 95/416 (22%), Positives = 148/416 (35%), Gaps = 38/416 (9%)

Query: 207   TSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYS 266
             +SSE D   +   H              FF  ++   S  + +  A V S++   P + S
Sbjct: 10589 SSSEPDTTASWVIHPAETIPTVSKTTPNFFHSELDTVSSTATSHGADVSSAI---PTNIS 10645

Query: 267   HDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEG 326
                L  ++P  T +  +          S  ET+ R   +++  P    +T  IPRT P  
Sbjct: 10646 PSELDALTPLVTISGTDTSTTFPTLTKSPHETETRTTWLTH--PAETSST--IPRTIPNF 10701

Query: 327   TLGQTSKLDTIPDIPPPRPPKPHPAHDRSP--VETCSIPRTASDTDSSYCIPTAGMSPSR 384
             +  ++    +I   P        P    SP   +  +   T+S TD +  IPT  +SP  
Sbjct: 10702 SHHESDATPSIATSPGAETSSAIPIMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGE 10761

Query: 385   SNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELD 444
               TI+++  +   + +S+     IP +  S   S L        V +++T  S++++   
Sbjct: 10762 PKTIASLVTHPEAQTSSA-----IPTSTISPAVSRL--------VTSMVT--SLAAKTST 10806

Query: 445   ENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTP 504
              N    N    P    S  T P Q +  VP T   F  S            G  SS    
Sbjct: 10807 TNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDTTPSMTTSHGAESSSAV- 10865

Query: 505   PRRPVPVADCEPPPVDRNLKPDRK---GQSPKILRLKPHGLERTDSQTIGDFATRRKVKP 561
                P P    E P V   L    +     +  IL L P   E T S             P
Sbjct: 10866 ---PTPTVSTEVPGVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHGEEASSAIP 10922

Query: 562   APLEIKPLPEWEELQAPVRSPITRSFARDSSRFP-MSPRPDSVHSTTSSSDSHDSE 616
              P     +P        V S +T S A  S+  P ++       +T S + SH +E
Sbjct: 10923 TPTVSPGVP------GVVTSLVTSSRAVTSTTIPILTFSLGEPETTPSMATSHGTE 10972



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 26/92 (28%), Positives = 35/92 (38%), Gaps = 20/92 (21%)

Query: 284  LYVFNTPSGTSSVETQMRHVSISYDIPP----------TPGNTYQIPRTFPEGTLGQTSK 333
            L +  T S  +S++  M   S+S  + P          TPG T Q   TF +     TS+
Sbjct: 1057 LPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSR 1116

Query: 334  LDTI----------PDIPPPRPPKPHPAHDRS 355
              TI          P +    PP P P   RS
Sbjct: 1117 EITIPRDGTSSALTPQMTATHPPSPDPGSARS 1148



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 67/298 (22%), Positives = 116/298 (38%), Gaps = 35/298 (11%)

Query: 116  GFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQL----------I 165
            G + T  + V P  ++  +  ++P + + +P S  ADS ++    P  +          I
Sbjct: 7166 GKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAI 7225

Query: 166  NVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHAD--SAKSTS---SETDCNDNVPSH 220
            + P  LET  IQ++       I+  S K   T +  +  SA  TS   SE          
Sbjct: 7226 STPHFLETSRIQKES------ISSLSPKLRETGSSVETSSAIETSAVLSEVSIGATTEIS 7279

Query: 221  KNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSP--SST 278
            +   +S S+  ++G  +  M+ +   +R       S +  L  S    +  + SP  S++
Sbjct: 7280 RTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPI--LAESSEMTIKTQTSPPGSTS 7337

Query: 279  EADGELYVFNTPS---GTSSVETQMRHVSISYDIPPTPGNTYQIPRTFP-EGTLGQTSKL 334
            E+   L    TPS     S++  ++ H  I+  +    G+  + P + P E T   +S+L
Sbjct: 7338 ESTFTLDTSTTPSLVITHSTMTQRLPHSEITTLVSRGAGDVPR-PSSLPVEETSPPSSQL 7396

Query: 335  DTIPDIPPPRPPKPHPAHDRS---PVETCSIPRTASDTD--SSYCIPTAGMSPSRSNT 387
                 I P       PA   S    V +   P     T+   +   P     PS S+T
Sbjct: 7397 SLSAMISPSPVSSTLPASSHSSSASVTSLLTPGQVKTTEVLDASAEPETSSPPSLSST 7454


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 66/285 (23%), Positives = 92/285 (32%), Gaps = 40/285 (14%)

Query: 118  NPTEEDPVKPPGSSLQAPADL----PLAINTAPPSTQADSSSATLP--PPYQLINVPPHL 171
            +P    P+ PP S+   P       P    T PP T   S   T P  PP     +PP  
Sbjct: 1501 SPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP-- 1558

Query: 172  ETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHG 231
             T      P          +  P PT T +    +T S        P    P ++ S   
Sbjct: 1559 -TTTPSPPPTT--------TTTPPPTTTPSPPTTTTPSPPTITTTTPP---PTTTPSPPT 1606

Query: 232  MNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVS-----------PSSTEA 280
                        SPP+  P  +  +S   LP + +    P  +           P++T  
Sbjct: 1607 TTTTTPPPTTTPSPPTTTP-ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTP 1665

Query: 281  DGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEG--TLGQTSKLDTIP 338
               +    TP  T++  + +     +   PPT   T   P T P    T   T    T P
Sbjct: 1666 SPPITTTTTPPPTTTPSSPIT----TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTP 1721

Query: 339  DIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPS 383
              PP     P P    SP  T     T   T +S  + T  + PS
Sbjct: 1722 SPPPTTMTTPSPTTTPSPPTTTM--TTLPPTTTSSPLTTTPLPPS 1764



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 59/279 (21%), Positives = 88/279 (31%), Gaps = 22/279 (7%)

Query: 125  VKPPGSSLQAPADLPLAINTAPPST--QADSSSATLPPPYQLINVPPHLETL---GIQED 179
            +  P      P+  P +  T PP+T     +++ T PPP    + P    T         
Sbjct: 1396 ITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPS 1455

Query: 180  PQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQ 239
            P          +  P P  T      +T S        P    P ++ S           
Sbjct: 1456 PPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPP---PTTTPSPPTTTPITPPA 1512

Query: 240  MIYDSPPSRAPSASVDSSLYNLPRSYSH--DVLPKVSPSSTEADGELYVFNTPSGTSSV- 296
                 PP+  PS    ++    P +        P   P+ST         + P  T++  
Sbjct: 1513 STTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP 1572

Query: 297  --ETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDR 354
               T     + +   PPT   T   P T P      T+   T P    P PP   P    
Sbjct: 1573 PPTTTPSPPTTTTPSPPTITTTTPPPTTTPS---PPTTTTTTPPPTTTPSPPTTTPI--T 1627

Query: 355  SPVETCSIPRTAS----DTDSSYCIPTAGMSPSRSNTIS 389
             P  T ++P T +     T ++   PT   SP  + T S
Sbjct: 1628 PPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS 1666



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 54/276 (19%), Positives = 84/276 (30%), Gaps = 29/276 (10%)

Query: 120  TEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQED 179
            T   P   P   +      P     +PP+T     + T  PP      PP   T      
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTT---PSP 1502

Query: 180  PQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQ 239
            P    +     +    PT T +    +T++        P    P +  +           
Sbjct: 1503 PTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS---------- 1552

Query: 240  MIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQ 299
                 PP+  PS    ++    P +          P++T          TP  T++    
Sbjct: 1553 -TTTLPPTTTPSPPPTTTTTPPPTT------TPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605

Query: 300  MRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKL--DTIPDIPPPRPPKPHPAHDRSP- 356
                +      P P  T   P T P      T+ L   T P  PP     P P    SP 
Sbjct: 1606 TTTTT-----TPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPP 1660

Query: 357  -VETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTV 391
               T S P T + T      P++ ++ + S   +T+
Sbjct: 1661 TTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTM 1696


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 110/503 (21%), Positives = 171/503 (33%), Gaps = 83/503 (16%)

Query: 120 TEEDPVKPP-GSSLQAPADLPLA------INTAPPSTQADSSSATLP-----PPYQL--- 164
           T+  PV PP  ++   PA LP +      +  APPS  A  S  TLP     PP Q    
Sbjct: 312 TKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPS 371

Query: 165 -----INVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPS 219
                +  PP L+T+   + P      +   S +  P+     S ++T+          S
Sbjct: 372 MTTPPMQAPPSLQTIPPIQVPHS----LTSPSLQAPPSPLALSSLQATT----------S 417

Query: 220 HKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTE 279
             +P    +   +    +Q     + PSR  S   DS     P S     LP   P  T 
Sbjct: 418 LGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLS-----LPASPPLQTS 472

Query: 280 ADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD 339
               +   ++P    ++       S++   P  P ++  +P    + +L   S L T P 
Sbjct: 473 LSPAVSPLSSP---LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPS-LQTPPA 528

Query: 340 IPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399
                P +  P+    P++T S P T    ++  C     +    S       L     +
Sbjct: 529 SLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPS------PLTTPPPE 582

Query: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNP--NSPPR 457
             S      P+A P+  S  L+G  +                       P++P    PP+
Sbjct: 583 TPSSIATPPPQAPPALASPPLQGLPS----------------------PPLSPLATPPPQ 620

Query: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEP- 516
                   P+Q     P +P     ++   Q P    +    +P +PP  P   A   P 
Sbjct: 621 APPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP 680

Query: 517 --PPVDRNLKPDRKGQSPKILRLKPHGLERTD--SQTIGDFATRRKVKPAPLEIKPLPEW 572
             PPV  +  P    Q+P  L   P  +  +   S  +   AT     P PL   PL   
Sbjct: 681 ASPPVSPSATP--PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL--- 735

Query: 573 EELQAPVRSPITRSFARDSSRFP 595
           +   +P  SP     A    R P
Sbjct: 736 QVPPSPPASPPMSPSATPPPRVP 758



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 69/266 (25%), Positives = 95/266 (35%), Gaps = 40/266 (15%)

Query: 117 FNPTEEDPVKPPGSS-LQAPADL---PLAINTAPPSTQADSSSATLPPPYQLINVPPHLE 172
           F+P    PV P  +   QAP  L   PL +  +PP++   S SAT PP       PP L 
Sbjct: 677 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP-----QAPPPLA 731

Query: 173 TLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGM 232
              +Q  P          S  P P      +A             P  + P S  +   M
Sbjct: 732 APPLQVPPSPPASPPMSPSATPPPRVPPLLAA-------------PPLQVPPSPPASLPM 778

Query: 233 NGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSG 292
           +   +       PP +AP A     L  LP   +    P  +P S  A   +    +P  
Sbjct: 779 SPLAK-------PPPQAPPALATPPLQALPSPPAS--FPGQAPFSPSASLPM----SPLA 825

Query: 293 TSSVETQMRHVSISYDIPPTP--GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHP 350
           T   +      +    +PP+P    T Q PR  P  T G  + +   P +     P P P
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP--TPGPDTSVSG-PRLTLALAPGPPP 882

Query: 351 AHDRSPVETCSIPRTASDTDSSYCIP 376
              RSP  T S P  A  + S+   P
Sbjct: 883 PPSRSPSSTLSGPDLAGHSSSATSTP 908



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 109/516 (21%), Positives = 166/516 (32%), Gaps = 81/516 (15%)

Query: 129 GSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLIN 188
           G  LQ PA   L+ +  P S+ A S  +    P      P H      Q  P+    L  
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTP----RAPAHPS----QPKPKGLQAL-- 280

Query: 189 CQSKKPEPTRTHADSA------KSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIY 242
              + P+ T    D+A       S+   T       +   P    +   +          
Sbjct: 281 ---RPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPL 337

Query: 243 DSP-PSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVET-QM 300
            +P P   PS S   SL  LP        P   PS             P    ++   Q+
Sbjct: 338 ATPLPLAPPSPSAPPSLQTLPSP------PATPPSQAPPSMTTPPMQAPPSLQTIPPIQV 391

Query: 301 RH--VSISYDIPPTPGNTYQIPRTFPEG--TLGQTSKLDTIPDIPPPRPPKPHPAHDRSP 356
            H   S S   PP+P     +  T   G  TL  T    T+        P+   A   SP
Sbjct: 392 PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS-------PRQTQASLTSP 444

Query: 357 VETCSIPRTASDTDSSYCIPTA-----GMSPSRSNTISTVDLNKLRKDASSQDCYDIPRA 411
               S P  +    +   +P +      +SP+ S   S + ++ L+             A
Sbjct: 445 SRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQ-------------A 491

Query: 412 FPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEAN 471
             S  S S +   +   +  + T  S++   L     P +  +PP ++  S   P  +  
Sbjct: 492 LSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP--PASLTTPPLENLPSLAPPPLQTA 549

Query: 472 YVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQS 531
             P+T    +        P P  +    SP T P    P +   PPP           Q+
Sbjct: 550 SAPLTTPHLETPP----CPAPCPLQAPPSPLTTPPPETPSSIATPPP-----------QA 594

Query: 532 PKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDS 591
           P  L   P  L+   S  +   AT     P  L + PL      QAP   P +   +  +
Sbjct: 595 PPALASPP--LQGLPSPPLSPLATPPPQAPPXLALPPL------QAPPSPPASPPLSPLA 646

Query: 592 SRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLS 627
           +  P +P   +VH   +      S     P +P  S
Sbjct: 647 TPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 682


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 93/413 (22%), Positives = 132/413 (31%), Gaps = 26/413 (6%)

Query: 249  APSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYD 308
            +PSA+ D+S ++    YS    P      +      Y+   PS   ++       S +Y+
Sbjct: 1547 SPSAASDASGFS--PGYSPAWSPTPGSPGSPGPSSPYI---PSPGGAMSPSYSPTSPAYE 1601

Query: 309  IPPTPGNTYQIPR---TFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRT 365
                 G T Q P    T P  +    S   T P+  P  P     +   SP      P +
Sbjct: 1602 PRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTS 1661

Query: 366  AS--DTDSSYCIPTAGM----SPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSS 419
             S   T  SY  PT+      SPS S T  +          +S        ++     S 
Sbjct: 1662 PSYSPTSPSYS-PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSY 1720

Query: 420  LEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPI---QEANYVPMT 476
                 ++       +  S S      NY P +PN  P   S S T P       NY P +
Sbjct: 1721 SPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTS 1780

Query: 477  PGTFDFS-SFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKIL 535
            P     S S+    P  +      SP +P   P         P      P     SPK  
Sbjct: 1781 PNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYT 1840

Query: 536  RLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF- 594
               P     +   T     T  K  P   +  P        +P  SP T  ++  S  + 
Sbjct: 1841 PTSPSYSPSSPEYT----PTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYS 1896

Query: 595  PMSP--RPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSP 645
            P SP   P S   + +S     +   Y P +P  S   P     +    G SP
Sbjct: 1897 PTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSP 1949



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 48/211 (22%), Positives = 72/211 (34%), Gaps = 17/211 (8%)

Query: 446  NYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPP 505
            +Y P +P+  P   S S T P    NY P +P      S+    P  +      SP +P 
Sbjct: 1614 SYSPTSPSYSPTSPSYSPTSP----NYSPTSP------SYSPTSPSYSPTSPSYSPTSPS 1663

Query: 506  RRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLE 565
              P   +     P      P     SP      P     + S +     T     P    
Sbjct: 1664 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS----PTSPSYSPTSPS 1719

Query: 566  IKPLPEWEELQAPVRSPITRSFARDSSRF-PMSPR--PDSVHSTTSSSDSHDSEENYVPM 622
              P        +P  SP + S++  S  + P SP   P S   + +S     +  NY P 
Sbjct: 1720 YSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPT 1779

Query: 623  NPNLSSEDPNLFGSNSLDGGSSPMIKPKGDK 653
            +PN S   P+   ++     +SP   P   +
Sbjct: 1780 SPNYSPTSPSYSPTSPSYSPTSPSYSPSSPR 1810



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 51/221 (23%), Positives = 75/221 (33%), Gaps = 12/221 (5%)

Query: 437  SVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFS-SFGMQVPPPAHM 495
            S S      +Y P +P+  P   S S T P    +Y P +P     S S+    P  +  
Sbjct: 1661 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSP----SYSPTSPSYSPTSPSYSPTSPSYSPT 1716

Query: 496  GFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFAT 555
                SP +P   P   +     P      P+    SP      P     + S +     T
Sbjct: 1717 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYS----PT 1772

Query: 556  RRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF-PMSPR--PDSVHSTTSSSDS 612
                 P      P        +P  SP + S++  S R+ P SP   P S   + SS   
Sbjct: 1773 SPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSY 1832

Query: 613  HDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDK 653
              +   Y P +P+ S   P    ++     +SP   P   K
Sbjct: 1833 SPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPK 1873



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 53/221 (23%), Positives = 76/221 (34%), Gaps = 12/221 (5%)

Query: 437  SVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFS-SFGMQVPPPAHM 495
            S S      +Y P +P+  P   S S T P    +Y P +P     S S+    P  +  
Sbjct: 1654 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSP----SYSPTSPSYSPTSPSYSPTSPSYSPT 1709

Query: 496  GFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFAT 555
                SP +P   P   +     P      P     SP      P+    + S +     T
Sbjct: 1710 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYS----PT 1765

Query: 556  RRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF-PMSPR--PDSVHSTTSSSDS 612
                 P      P        +P  SP + S++  S  + P SPR  P S   T SS   
Sbjct: 1766 SPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSY 1825

Query: 613  HDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDK 653
              S  +Y P +P  +   P+   S+     +SP   P   K
Sbjct: 1826 SPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPK 1866



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 47/206 (22%), Positives = 73/206 (35%), Gaps = 17/206 (8%)

Query: 447  YVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPR 506
            Y P +P+  P   S S T P    +Y P +P  +  +S       P++     SP +P  
Sbjct: 1608 YTPQSPSYSPTSPSYSPTSP----SYSPTSPN-YSPTSPSYSPTSPSY-----SPTSPSY 1657

Query: 507  RPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEI 566
             P   +     P      P     SP      P     + S +     T     P     
Sbjct: 1658 SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS----PTSPSYSPTSPSY 1713

Query: 567  KPLPEWEELQAPVRSPITRSFARDSSRF-PMSPR--PDSVHSTTSSSDSHDSEENYVPMN 623
             P        +P  SP + S++  S  + P SP   P S + T +S     +  +Y P +
Sbjct: 1714 SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTS 1773

Query: 624  PNLSSEDPNLFGSNSLDGGSSPMIKP 649
            PN +   PN   ++     +SP   P
Sbjct: 1774 PNYTPTSPNYSPTSPSYSPTSPSYSP 1799



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 52/221 (23%), Positives = 74/221 (33%), Gaps = 12/221 (5%)

Query: 437  SVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFS-SFGMQVPPPAHM 495
            S S      +Y P +P+  P   S S T P    +Y P +P     S S+    P  +  
Sbjct: 1647 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSP----SYSPTSPSYSPTSPSYSPTSPSYSPT 1702

Query: 496  GFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFAT 555
                SP +P   P   +     P      P     SP      P+    + + T     T
Sbjct: 1703 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYT----PT 1758

Query: 556  RRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF-PMSPR--PDSVHSTTSSSDS 612
                 P      P        +P  SP + S++  S  + P SP   P S   T  S   
Sbjct: 1759 SPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTY 1818

Query: 613  HDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDK 653
              S  +Y P +P+ S   P    ++     SSP   P   K
Sbjct: 1819 TPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPK 1859



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 52/219 (23%), Positives = 76/219 (34%), Gaps = 15/219 (6%)

Query: 437  SVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFS-SFGMQVPPPAHM 495
            S S      +Y P +P+  P   S S T P    +Y P +P     S S+    P  +  
Sbjct: 1682 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSP----SYSPTSPSYSPTSPSYSPTSPSYSPT 1737

Query: 496  GFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFAT 555
                SP +P   P         P      P     SP      P+    + S +     T
Sbjct: 1738 SPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYS----PT 1793

Query: 556  RRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRF-PMSPRPDSVHSTTSSSDSHD 614
                 P      P       Q+P  +P + S++  S  + P SP+    ++ TS S S  
Sbjct: 1794 SPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPK----YTPTSPSYSPS 1849

Query: 615  SEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDK 653
            S E Y P +P  S   P    ++     +SP   P   K
Sbjct: 1850 SPE-YTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPK 1887


>gi|221219026 pleckstrin homology-like domain, family B, member 1
            isoform b [Homo sapiens]
          Length = 1319

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 10/106 (9%)

Query: 7    VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
            VC G+L K   + K    +WK+RWFV    + T     L YY + H  K   +I     +
Sbjct: 1211 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1261

Query: 67   QVDAG-LTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
            +V    L    K    +  F + T DR++Y+VA S E M  W+  I
Sbjct: 1262 EVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307


>gi|221219024 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 21/117 (17%)

Query: 7    VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
            VC G+L K   + K    +WK+RWFV    + T     L YY + H  K   +I     +
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308

Query: 67   QV--DAGLTFNKKEF----------ENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
            +V  D   +  KK F            +  F + T DR++Y+VA S E M  W+  I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365


>gi|38424073 pleckstrin homology-like domain, family B, member 1
            isoform a [Homo sapiens]
          Length = 1377

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 21/117 (17%)

Query: 7    VCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQ 66
            VC G+L K   + K    +WK+RWFV    + T     L YY + H  K   +I     +
Sbjct: 1258 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1308

Query: 67   QV--DAGLTFNKKEF----------ENSYIFDINTIDRIFYLVADSEEEMNKWVRCI 111
            +V  D   +  KK F            +  F + T DR++Y+VA S E M  W+  I
Sbjct: 1309 EVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1365


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 39/178 (21%)

Query: 4   GEVVCSGWL--RKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIID 61
           G   C GWL  RK+P      R  W+RRWFVL+          L +Y+    +K   +I+
Sbjct: 395 GRPDCDGWLLLRKAPGGFMGPR--WRRRWFVLKG-------HTLYWYRQPQDEKAEGLIN 445

Query: 62  LNLCQQVDAGLTFNKKEFENSYIFDI-NTIDRIFYLVADSEEEMNKWVR----CIC---- 112
           ++    +++G    KK     Y+F + + + + F   AD+  +++ WVR    CI     
Sbjct: 446 VS-NYSLESGHDQKKK-----YVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQS 499

Query: 113 ---------DICGFNPTEEDPVKPPGSSLQAP----ADLPLAINTAPPSTQADSSSAT 157
                    + C      EDP    GS   +P    A  PL  +T+P +T    S  T
Sbjct: 500 PGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRT 557


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,722,688
Number of Sequences: 37866
Number of extensions: 2097511
Number of successful extensions: 11134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 9413
Number of HSP's gapped (non-prelim): 1949
length of query: 724
length of database: 18,247,518
effective HSP length: 110
effective length of query: 614
effective length of database: 14,082,258
effective search space: 8646506412
effective search space used: 8646506412
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.