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Search of human proteins with 46249349
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46249349 homer 2 isoform 1 [Homo sapiens]
(343 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46249349 homer 2 isoform 1 [Homo sapiens] 674 0.0
gi|46249351 homer 2 isoform 2 [Homo sapiens] 665 0.0
gi|110349794 homer 2 isoform 3 [Homo sapiens] 451 e-127
gi|110349797 homer 2 isoform 4 [Homo sapiens] 442 e-124
gi|4759198 homer 1 [Homo sapiens] 346 2e-95
gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [... 293 2e-79
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [... 293 2e-79
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 289 2e-78
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [... 253 2e-67
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 70 3e-12
gi|56549694 enabled homolog isoform a [Homo sapiens] 68 1e-11
gi|39930375 enabled homolog isoform b [Homo sapiens] 68 1e-11
gi|16262452 cingulin [Homo sapiens] 66 5e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 2e-10
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 63 3e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 61 2e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 61 2e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 61 2e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 61 2e-09
gi|38044112 restin isoform b [Homo sapiens] 60 3e-09
gi|4506751 restin isoform a [Homo sapiens] 60 3e-09
gi|156104908 myosin heavy chain 6 [Homo sapiens] 59 5e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 59 5e-09
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 59 8e-09
gi|71061468 centromere protein E [Homo sapiens] 58 1e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 57 2e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 57 2e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 56 4e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 56 4e-08
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 674 bits (1738), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR 180
IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR
Sbjct: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR 180
Query: 181 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR 240
ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR
Sbjct: 181 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR 240
Query: 241 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 300
RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD
Sbjct: 241 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 300
Query: 301 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 301 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 665 bits (1716), Expect = 0.0
Identities = 343/354 (96%), Positives = 343/354 (96%), Gaps = 11/354 (3%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQ-----------ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
IETSSNHSQ ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 170 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 229
KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN
Sbjct: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
Query: 230 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 289
REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
Sbjct: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
Query: 290 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 451 bits (1159), Expect = e-127
Identities = 247/343 (72%), Positives = 266/343 (77%), Gaps = 55/343 (16%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR 180
IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVK EI +
Sbjct: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKN-EINRE--- 176
Query: 181 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR 240
+++N +L+ +I+ELE + +EK T+LK
Sbjct: 177 ---------------------------KEKNTQLKRRIEELEAEL------REKETELK- 202
Query: 241 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 300
+LR++ + L + E + + + E RDNQNLEDKVRSLKTD
Sbjct: 203 -------DLRKQSEIIPQLMSECEYVSEKLEAAE----------RDNQNLEDKVRSLKTD 245
Query: 301 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 246 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 442 bits (1137), Expect = e-124
Identities = 247/354 (69%), Positives = 266/354 (75%), Gaps = 66/354 (18%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHS-----------QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
IETSSNHS QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 170 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 229
K EI + +++N +L+ +I+ELE +
Sbjct: 181 KN-EINRE------------------------------KEKNTQLKRRIEELEAEL---- 205
Query: 230 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 289
+EK T+LK +LR++ + L + E + + + E RDNQN
Sbjct: 206 --REKETELK--------DLRKQSEIIPQLMSECEYVSEKLEAAE----------RDNQN 245
Query: 290 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 246 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 299
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 346 bits (888), Expect = 2e-95
Identities = 183/351 (52%), Positives = 248/351 (70%), Gaps = 13/351 (3%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIF+TRAHVFQIDPNTKKNW+P SK AVTVSYFYD TRN YRIIS+DG+K IINST
Sbjct: 1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTV+GLGFSSE L+KFAEKFQE KEAA++AK+K+QEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK 120
Query: 121 IETSSNHSQAS------------SVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAAN 168
+E +S SQ S S+NGTDDE+ N+ ++E + + + S+A
Sbjct: 121 MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDV-TQNSEPRAEPTQNALPFSHSSAI 179
Query: 169 VKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEI 228
K WE EL TL+ +NA+LT AL ES A+V+QWK+Q + ++E +RL ++ ELE S+
Sbjct: 180 SKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQA 239
Query: 229 NREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQ 288
N T+L + I+ELE L+ KE E++ L+++ + +L + + +++KL+ E N+
Sbjct: 240 NAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNK 299
Query: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
+LE ++ L+ +E+S+ Q + LK+ LE+LDGKI +L + R L+KL
Sbjct: 300 DLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKL 350
>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 293 bits (749), Expect = 2e-79
Identities = 161/351 (45%), Positives = 234/351 (66%), Gaps = 14/351 (3%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
+S +H S S NG +EK + A+ +E ++LK L++ + +W
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231
E E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDNQ 288
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
Query: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 293 bits (749), Expect = 2e-79
Identities = 161/351 (45%), Positives = 234/351 (66%), Gaps = 14/351 (3%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
+S +H S S NG +EK + A+ +E ++LK L++ + +W
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231
E E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDNQ 288
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
Query: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 289 bits (740), Expect = 2e-78
Identities = 160/349 (45%), Positives = 230/349 (65%), Gaps = 13/349 (3%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
+S +H S S NG +EK + A+ +E ++LK L++ + +W
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231
E E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNL 290
EK + +E+LEA ++ K+ E++ L+ Q+ P+ E E + + N L
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-GPREALEAAEREETQQKVQTRNAEL 304
Query: 291 EDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
E ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 305 EHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
[Homo sapiens]
Length = 325
Score = 253 bits (646), Expect = 2e-67
Identities = 143/341 (41%), Positives = 208/341 (60%), Gaps = 30/341 (8%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQVPP--------------------- 104
Query: 123 TSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRES 182
S S NG +EK + A+ +E ++LK L++ + +WE E L++S
Sbjct: 105 -----SPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDS 159
Query: 183 NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINREKEK-NTQLKR 240
N +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+ EK +
Sbjct: 160 NNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQ 219
Query: 241 RIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDNQNLEDKVRSLK 298
+E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N LE ++R+++
Sbjct: 220 SLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAME 279
Query: 299 TDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
+EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 280 RSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 320
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 70.1 bits (170), Expect = 3e-12
Identities = 72/262 (27%), Positives = 134/262 (51%), Gaps = 36/262 (13%)
Query: 93 EQQLTKFAEKFQEVKEAAK---IAKDKTQEKIETSSNHSQASS--VNGTDDEKASHAGPA 147
E+ L +F E Q+ + K + + K +E+I +N+ Q + ++E+ ++
Sbjct: 1158 ERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETN---- 1213
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
+ E +KLK L+ S+A + + +LQ E A L L ++ ++Q +++ S+
Sbjct: 1214 ----RQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVM 1269
Query: 208 RDENDRLRNKIDELEE---QCS-EINREKEKNTQLKRRI--EELEAELREKETELKDLRK 261
RDE+ LR KI+ELE+ QCS E++ ++ QLK ++ +++E +++ E KDL
Sbjct: 1270 RDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNV 1329
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLE---DKVRSLKTDIE---------ESKYRQR 309
+ +II + E E+ + +Q LE ++V L T++E E+K QR
Sbjct: 1330 KEKIIEDMRMTLE---EQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQR 1386
Query: 310 HLKVELKSFLEVLDGKIDDLHD 331
K E ++ +VL GK+ +L D
Sbjct: 1387 SNK-EHENNTDVL-GKLTNLQD 1406
Score = 47.8 bits (112), Expect = 1e-05
Identities = 57/234 (24%), Positives = 95/234 (40%), Gaps = 35/234 (14%)
Query: 103 FQEVKEAAKIAKDKTQ--EKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
++E KE K + K+ E++E QA V G DE N LK + K +
Sbjct: 1021 WEECKEIVKASSKKSHQIEELEQQIEKLQAE-VKGYKDE--------NNRLKEKEHKNQD 1071
Query: 161 ALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 220
L +K+ E +Q L+E L V + KR S + KI E
Sbjct: 1072 DL------LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKE 1125
Query: 221 LEE-------QCS-------EINREKEKNTQLKRRIEELEAELREKETELKDLR----KQ 262
LE +CS +I ++ +L+R ++E + L++ KDL K
Sbjct: 1126 LETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKL 1185
Query: 263 SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 316
E I QL + + + L+ E + + + LK ++ S R ++LK +L+
Sbjct: 1186 KEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ 1239
Score = 43.5 bits (101), Expect = 3e-04
Identities = 38/168 (22%), Positives = 79/168 (47%), Gaps = 14/168 (8%)
Query: 162 LTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDEL 221
L Q KK I + + + + + ++ + A +E + + ++ N+ LR + +
Sbjct: 799 LQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIR----VLQENNEGLRAFLLTI 854
Query: 222 EEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE 281
E +E+ EKE+ +L ++I + EL E + L K+ + Q+ S + +L
Sbjct: 855 E---NELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKE---VQQIQSNYDIAIAELH 908
Query: 282 AAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
+ NQ E+K+ L +IE + R + + S ++++ KID+L
Sbjct: 909 VQKSKNQEQEEKIMKLSNEIETA---TRSITNNV-SQIKLMHTKIDEL 952
Score = 39.3 bits (90), Expect = 0.005
Identities = 51/258 (19%), Positives = 115/258 (44%), Gaps = 32/258 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQE-KIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
+++LT ++ ++V++ + +D+ + +I+ + + + + D K L
Sbjct: 1249 KEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL 1308
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
N K++ A+ Q K ++ + + + R+T QE VEQ + +E
Sbjct: 1309 N--NQKVEEAIQQYERACKDLNVKEKIIEDM--RMTLEEQEQT-QVEQ-DQVLEAKLEEV 1362
Query: 212 DRLRNKIDELEEQCSEI--------NREKEKNTQLKRRIEELEAELREKETELKDLRKQS 263
+RL ++++ +E+C+++ N+E E NT + ++ L+ EL+E E + RK
Sbjct: 1363 ERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRK-- 1420
Query: 264 EIIPQLMSECEYVSEK--LEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
+++ EK L ++ +N+ +K + E ++Q++ E++
Sbjct: 1421 ----------KWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN---EMEILTAQ 1467
Query: 322 LDGKIDDLHDFRRGLSKL 339
L K DL +R +L
Sbjct: 1468 LTEKDSDLQKWREERDQL 1485
Score = 38.5 bits (88), Expect = 0.009
Identities = 31/131 (23%), Positives = 61/131 (46%), Gaps = 26/131 (19%)
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+ + + I+ + E+C EI + K + +IEELE ++ + + E+K
Sbjct: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSH---QIEELEQQIEKLQAEVKG---------- 1054
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 328
Y E E++++N +D ++ +T I++ LK EL+ LD +I
Sbjct: 1055 ------YKDENNRLKEKEHKNQDDLLKEKETLIQQ-------LKEELQEKNVTLDVQIQH 1101
Query: 329 LHDFRRGLSKL 339
+ + +R LS+L
Sbjct: 1102 VVEGKRALSEL 1112
Score = 32.3 bits (72), Expect = 0.63
Identities = 42/221 (19%), Positives = 93/221 (42%), Gaps = 26/221 (11%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDK-TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+LT ++ QE ++ + K +EK+ + +A ++ + +K + ++
Sbjct: 1400 KLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQN 1459
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
E + L LT+ ++++KW RE +L AL+ Q N +
Sbjct: 1460 EMEILTAQLTEKDSDLQKW-------REERDQLVAALE----------IQLKALISSNVQ 1502
Query: 214 LRNKIDELEEQCSEINREKEKNTQLK-RRIEELEAELREKE---TELKDLRKQSEIIPQL 269
N+I++L+ SE ++ + + +K +RI + + + E T + R + E +
Sbjct: 1503 KDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVV 1562
Query: 270 MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRH 310
+ CE +E ++ LE + T ++ +K +H
Sbjct: 1563 LDSCEVSTENDQSTRFPKPELEIQF----TPLQPNKMAVKH 1599
Score = 30.0 bits (66), Expect = 3.1
Identities = 33/140 (23%), Positives = 59/140 (42%), Gaps = 18/140 (12%)
Query: 188 TALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKE-----------KNT 236
T LQE E +R+ +I +D L K D EE +I K K
Sbjct: 623 TLLQEREILEENAERRLAIFKD----LVGKCDTREEAAKDICATKVETEEATACLELKFN 678
Query: 237 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 296
Q+K + + + EL + + ELK +S+ L+ E E ++K+ + + L + +
Sbjct: 679 QIKAELAKTKGELIKTKEELKKRENESD---SLIQELETSNKKIITQNQRIKELINIIDQ 735
Query: 297 LKTDIEESKYRQRHLKVELK 316
+ I E + + H++ K
Sbjct: 736 KEDTINEFQNLKSHMENTFK 755
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/275 (25%), Positives = 122/275 (44%), Gaps = 29/275 (10%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDK 116
IN I + + + +Q F QW D+R V+GL F S++ FA E + +
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEV--LNSQE 115
Query: 117 TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIE- 175
T + ++ A N GP+ L+ + +L+ Q ++ E E
Sbjct: 116 TGPTLPRQNSQLPAQVQN----------GPSQEELEIQRRQLQEQQRQKELERERLERER 165
Query: 176 -----LQTLRESNARL-TTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 229
L+ R RL L++ E+ +R+ + +RL + + LE Q ++
Sbjct: 166 MERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQ-ERLERQ-ERLD 223
Query: 230 REKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
RE+++ Q + R+E LE E +E+E + + R+Q E
Sbjct: 224 RERQER-QERERLERLERERQERERQEQLEREQLE 257
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/275 (25%), Positives = 122/275 (44%), Gaps = 29/275 (10%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDK 116
IN I + + + +Q F QW D+R V+GL F S++ FA E + +
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEV--LNSQE 115
Query: 117 TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIE- 175
T + ++ A N GP+ L+ + +L+ Q ++ E E
Sbjct: 116 TGPTLPRQNSQLPAQVQN----------GPSQEELEIQRRQLQEQQRQKELERERLERER 165
Query: 176 -----LQTLRESNARL-TTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 229
L+ R RL L++ E+ +R+ + +RL + + LE Q ++
Sbjct: 166 MERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQ-ERLERQ-ERLD 223
Query: 230 REKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
RE+++ Q + R+E LE E +E+E + + R+Q E
Sbjct: 224 RERQER-QERERLERLERERQERERQEQLEREQLE 257
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 65.9 bits (159), Expect = 5e-11
Identities = 68/266 (25%), Positives = 125/266 (46%), Gaps = 29/266 (10%)
Query: 88 LGFSSEQQLTKFAEKFQEVKEAAK--IAKDKTQEKIETSSNHSQASSVNGTDDE------ 139
+G S+Q L + + ++ KE A+ +A + Q K S + ++ DE
Sbjct: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
Query: 140 --KASHAGPANTHLKSENDKLKI-ALTQSAANVKKWEIE----LQTLRESNARLTTALQE 192
+AS A L E ++ L Q A N K+ + + L+ L E +RL T L E
Sbjct: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDE 980
Query: 193 SAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREK 252
+VE + + RD+ D+LR ++ ++E+ + + E +K L+R+ ++L+ L
Sbjct: 981 EKNTVELLTDRVNRGRDQVDQLRTEL--MQERSARQDLECDK-ISLERQNKDLKTRLASS 1037
Query: 253 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERD-------NQNLEDKVRSLKTDIEESK 305
E +K S + QL S+ + + E+L+A ER+ N+ LE KV+ L IE+ +
Sbjct: 1038 E----GFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDER 1093
Query: 306 YRQRHLKVELKSFLEVLDGKIDDLHD 331
K +L ++ L ++D+ +
Sbjct: 1094 QHVNDQKDQLSLRVKALKRQVDEAEE 1119
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/290 (21%), Positives = 117/290 (40%), Gaps = 31/290 (10%)
Query: 69 KTSQKFGQWA--------DSRANT--VFGLGFSSEQQLTKFAEKFQ----EVKEAAKIAK 114
+TS++ G W D RA + L E+ + EK + E+++A A
Sbjct: 563 ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAG 622
Query: 115 DKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEI 174
D Q ++ + E+ S A H E +K L A ++
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQSQE-VAGRHRDRELEKQLAVLRVEADRGRE--- 678
Query: 175 ELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK 234
L E N +L LQ+ E+ + + E L + +E + + +E+
Sbjct: 679 ----LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVE---TTLRETQEE 731
Query: 235 NTQLKRRIEELEAELREKET-----ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 289
N + +RRI LE +L+E E + R + ++ +L +E + + E L A++ + +
Sbjct: 732 NDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKL-QRLEAEKQQLEEALNASQEEEGS 790
Query: 290 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
L R+L+ +EE++ L E ++ L+ + RRG ++L
Sbjct: 791 LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840
Score = 38.9 bits (89), Expect = 0.007
Identities = 47/242 (19%), Positives = 104/242 (42%), Gaps = 31/242 (12%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
+++ L K + +E+ E K + +E++ + +++ G E+ + H+
Sbjct: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRER--ELTALKGALKEEVASRDQEVEHV 518
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQ----ESAASVEQWKRQFS-- 205
+ + + L +S + + L+ R+ + L LQ E++ W+ F
Sbjct: 519 RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKN 578
Query: 206 -----ICRDENDRLRNKIDELEEQCSE----INREKEK---NTQLKRRIEELEAELREKE 253
+ E +LR + +E+EE+ E + RE E+ + R++E L+ EL +
Sbjct: 579 KEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQ 638
Query: 254 TELKDL---RKQSEI--------IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE 302
ELK+L R+ E+ + + ++ +++ E N L+ ++ L+ D E
Sbjct: 639 EELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE 698
Query: 303 ES 304
E+
Sbjct: 699 EA 700
Score = 37.7 bits (86), Expect = 0.015
Identities = 46/229 (20%), Positives = 91/229 (39%), Gaps = 20/229 (8%)
Query: 100 AEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
+E V+ + +K Q + SS ++A + G K + KL+
Sbjct: 327 SESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLE 386
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
+ +++ E L+E R Q+S ++ KR D+ + LR+
Sbjct: 387 PSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLL----DQGEDLRHG-- 440
Query: 220 ELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEK 279
LE Q E L+ +++ ++ KE LKDL + E++ +++ + V E+
Sbjct: 441 -LETQVME----------LQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQ 489
Query: 280 LEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 328
L ER+ L+ +LK ++ H++ + + E L + D
Sbjct: 490 LRLRERELTALKG---ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
Score = 36.6 bits (83), Expect = 0.034
Identities = 50/237 (21%), Positives = 103/237 (43%), Gaps = 54/237 (22%)
Query: 79 DSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT---QEKIETSSNH--SQASSV 133
D RA + GL E+++++ + E K ++ D+ +++++ + S+
Sbjct: 958 DDRARQLKGL----EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR 1013
Query: 134 NGTDDEKASHAGPANTHLKSENDKLKIALTQS------AANVKKWEIELQTLRE---SNA 184
+ +K S L+ +N LK L S +A++ + E + Q L+E +
Sbjct: 1014 QDLECDKIS--------LERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065
Query: 185 RLTTALQESAASVEQWKRQFSI-CRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIE 243
R T LQ + +E+ ++ SI DE + ++ D+L + LKR+++
Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK----------ALKRQVD 1115
Query: 244 ELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 300
E E E+ L LRK+++ ++E N+ L+ +++SL+ D
Sbjct: 1116 EAEEEIE----RLDGLRKKAQ-------------REVEEQHEVNEQLQARIKSLEKD 1155
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.9 bits (154), Expect = 2e-10
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 10/176 (5%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWE---IELQTLRESNARLTTALQESAASVEQWKRQF 204
N L+SE ++LK L A+ KK E + Q L N RL L+ S ++Q + +
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
EN L+ ++EL+ + + +++N L++ +LE + ++ E E K LR+Q+E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 265 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 320
I + E + K+ E++N+ L ++ K ES R + L+ E K ++
Sbjct: 847 IKDTTLEE---NNVKIGNLEKENKTLSKEIGIYK----ESCVRLKELEKENKELVK 895
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/254 (19%), Positives = 118/254 (46%), Gaps = 44/254 (17%)
Query: 104 QEVKE-AAKIAKDKTQEK-IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
+ +KE ++K++K + +++ I+ H + + E H HL+ EN+ L+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH------HLEKENELLQKK 647
Query: 162 LTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDEL 221
+T +K E AL++ + +E+ R+ D L +++ L
Sbjct: 648 ITNLKITCEKIE---------------ALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 222 EEQCSEINREKEKNTQLKRRIE----------ELEAELREKETELKDLRKQSEIIPQLMS 271
E++ S+++ E+N +L+R +E +L+ E +E E+E + L+K E++
Sbjct: 693 EKENSQLD---EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 272 ECEYVSEKLEAAERDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 324
+ E + + + +NQ L+ K++ L++++++ + + L+ L+ L++
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSK 808
Query: 325 KIDDLHDFRRGLSK 338
+++ L + L +
Sbjct: 809 RLEQLEKENKSLEQ 822
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 25/173 (14%)
Query: 165 SAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELE-- 222
+++ + K E+E Q+L ++ L T + SVE + EN RL K++ LE
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVD----SVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 223 --------EQCSEINRE--KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 272
+ C ++++ KEK QL++ IE L E ++K L +++E + Q +S
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETLR---ENSERQIKILEQENEHLNQTVSS 569
Query: 273 CEYVSE-----KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 320
S+ +++ E++N+ L + ++ + + + ++ +R +K EL+ + E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Score = 43.9 bits (102), Expect = 2e-04
Identities = 42/232 (18%), Positives = 105/232 (45%), Gaps = 11/232 (4%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
+S +++ + + Q+++ + + +E +S Q N + +++ S
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTAL---QESAASVEQWKRQFS-I 206
L+ EN +L+ +++ +++ L + N L+ + +ES +++ +++ +
Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 207 CRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII 266
+ ++ + E+ SE + ++ N L++ ELE KE L D + +
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-- 951
Query: 267 PQLMSECEYVSEKLEAAERDNQNL-EDKVRSLKTDIEESKYRQRHLKVELKS 317
S + + KLE+ + + + E+K+ +L+ +EES + L+ ELK+
Sbjct: 952 ----SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Score = 42.0 bits (97), Expect = 8e-04
Identities = 50/222 (22%), Positives = 95/222 (42%), Gaps = 14/222 (6%)
Query: 115 DKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEI 174
D +QE IE + A + DE+ H+ L E D L S++
Sbjct: 180 DMSQEDIEPLLKN-MALHLKRLIDERDEHSETI-IELSEERDGLHFLPHASSSAQSPCGS 237
Query: 175 ELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK 234
ES L+ L ++ A + + +++ ++ ++L + ELE+ E+ R +++
Sbjct: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELE---EKTEQLLDCKQELEQMEIELKRLQQE 294
Query: 235 NTQL-------KRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN 287
N L + +EL+A LREK + L + + + + E+ ++E + DN
Sbjct: 295 NMNLLSDARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 288 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
Q L + L+ +E ++ R L K L+ L K+ D+
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 39.7 bits (91), Expect = 0.004
Identities = 40/173 (23%), Positives = 75/173 (43%), Gaps = 18/173 (10%)
Query: 162 LTQSAANVKKWEIELQTLRESNARL------TTALQESAASVEQWKRQFSICRDENDRLR 215
L A + + + EL LRE R+ + +E +E +K + +++N L
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 216 NKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII--------- 266
LE+Q +K +L++ +L+A+L + E E RK+ E +
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 267 --PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 317
Q M E ++ +LE R ++ E +SL ++ E R LK+E+++
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT-SSRLLKLEMEN 469
Score = 38.5 bits (88), Expect = 0.009
Identities = 44/250 (17%), Positives = 102/250 (40%), Gaps = 21/250 (8%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPAN 148
E+ +T + Q + E+ + + Q ++ + S VN + N
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 208
L ++L+ + N K + + + N RL+ ++ + Q K+ C+
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASK----ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQL----KRRIEELEAELREK-----ETELKDL 259
+ + L + +LE+ + E+ ++ + + + LR++ E +KD+
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 260 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
K+++I+ + + E S KL E + + ++ ++ K E ++ + L L+
Sbjct: 586 EKENKILHESIKE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKEN 641
Query: 320 EVLDGKIDDL 329
E+L KI +L
Sbjct: 642 ELLQKKITNL 651
Score = 38.5 bits (88), Expect = 0.009
Identities = 41/226 (18%), Positives = 93/226 (41%), Gaps = 39/226 (17%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQASSVN------GTDDEKASHAGPANTHLKSENDKL 158
++K + +D EK++T ++ + G + E+ H +++ +
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH-----DEQSTDDSRY 954
Query: 159 KIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKI 218
K+ ++ + +KK L+ E A L L+ES +Q +++ + + L+ +
Sbjct: 955 KLLESKLESTLKK---SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 219 DE----------------LEEQCSEINRE----KEKNTQLKRRIEELEAELREKETELKD 258
DE E + E RE K++ +++R L+AE + +T+LK
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
L Q+ + + + ++ + + QN + ++ K +E S
Sbjct: 1072 LETQNNNL-----QAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1112
Score = 35.0 bits (79), Expect = 0.098
Identities = 56/278 (20%), Positives = 108/278 (38%), Gaps = 61/278 (21%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+QL K + ++ E +++ KDK Q + E QA + T +E G K+
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 154 ENDKLKIALTQSAANVKKWEIE--------------LQTLRESNARLTTALQESAASVEQ 199
+ ++ I +S +K+ E E L TLRE Q+ +E+
Sbjct: 869 LSKEIGI-YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 200 WKRQFS--------ICRDENDR-------LRNKIDELEEQCSEINREKEKNTQLKRRIEE 244
+ + DE L +K++ ++ EI ++EK L+ R+EE
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI--KEEKIAALEARLEE 985
Query: 245 LEAELREKETELKDLRKQSEIIPQLMSECEY---------------------------VS 277
++ ELK ++K E + Q E V
Sbjct: 986 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1045
Query: 278 EKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
++L ER+N L+ + ++LKT +++ + + +L+ ++
Sbjct: 1046 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Score = 33.9 bits (76), Expect = 0.22
Identities = 39/172 (22%), Positives = 75/172 (43%), Gaps = 21/172 (12%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L END+L +Q E + L+ + L + L S + + +FS
Sbjct: 1243 LCGENDRLNHTYSQLLK-------ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS----- 1290
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEII 266
+L+ + +L+ +++N + E +QLK +EE L ++ L + L +Q+
Sbjct: 1291 --KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1348
Query: 267 PQL--MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 316
L + + +Y+ +KL R + LE+K+ + S R+R + LK
Sbjct: 1349 KDLFHVEQRQYI-DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK 1399
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 63.9 bits (154), Expect = 2e-10
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 10/176 (5%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWE---IELQTLRESNARLTTALQESAASVEQWKRQF 204
N L+SE ++LK L A+ KK E + Q L N RL L+ S ++Q + +
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
EN L+ ++EL+ + + +++N L++ +LE + ++ E E K LR+Q+E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 265 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 320
I + E + K+ E++N+ L ++ K ES R + L+ E K ++
Sbjct: 847 IKDTTLEE---NNVKIGNLEKENKTLSKEIGIYK----ESCVRLKELEKENKELVK 895
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/254 (19%), Positives = 118/254 (46%), Gaps = 44/254 (17%)
Query: 104 QEVKE-AAKIAKDKTQEK-IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
+ +KE ++K++K + +++ I+ H + + E H HL+ EN+ L+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH------HLEKENELLQKK 647
Query: 162 LTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDEL 221
+T +K E AL++ + +E+ R+ D L +++ L
Sbjct: 648 ITNLKITCEKIE---------------ALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 222 EEQCSEINREKEKNTQLKRRIE----------ELEAELREKETELKDLRKQSEIIPQLMS 271
E++ S+++ E+N +L+R +E +L+ E +E E+E + L+K E++
Sbjct: 693 EKENSQLD---EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 272 ECEYVSEKLEAAERDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 324
+ E + + + +NQ L+ K++ L++++++ + + L+ L+ L++
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSK 808
Query: 325 KIDDLHDFRRGLSK 338
+++ L + L +
Sbjct: 809 RLEQLEKENKSLEQ 822
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 25/173 (14%)
Query: 165 SAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELE-- 222
+++ + K E+E Q+L ++ L T + SVE + EN RL K++ LE
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVD----SVEGNASKILKMEKENQRLSKKVEILENE 513
Query: 223 --------EQCSEINRE--KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 272
+ C ++++ KEK QL++ IE L E ++K L +++E + Q +S
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEK-AQLEKTIETLR---ENSERQIKILEQENEHLNQTVSS 569
Query: 273 CEYVSE-----KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 320
S+ +++ E++N+ L + ++ + + + ++ +R +K EL+ + E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Score = 42.7 bits (99), Expect = 5e-04
Identities = 79/335 (23%), Positives = 135/335 (40%), Gaps = 82/335 (24%)
Query: 64 NMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVK---EAAKIAKDK-TQE 119
N + ++K + DS N F L S E++ ++ E+ E++ E+ K A K Q
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 120 KIETSSNHSQASSVN-GTDDEKASHAGPANTH-----LKSENDKLKIALTQSAANVKKWE 173
++E S+ + G + KAS L EN +L+ L S +++ E
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 174 IELQTLRESNARLTTALQE---SAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINR 230
ELQ L N L L+E S+ +EQ +++ E +L +LE++ + +
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Query: 231 EKE-KNTQLKR---RIEELEAE-----------------LREKETELKDLRKQSEI-IPQ 268
+ E K+T L+ +I LE E L+E E E K+L K++ I I
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 269 LMSECE-YVSEKLEAAERDN---------------------------------------- 287
L++ E VSEKL+ + +N
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963
Query: 288 -----QNLEDKVRSLKTDIEESKYRQRHLKVELKS 317
+ E+K+ +L+ +EES + L+ ELK+
Sbjct: 964 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Score = 42.0 bits (97), Expect = 8e-04
Identities = 50/222 (22%), Positives = 95/222 (42%), Gaps = 14/222 (6%)
Query: 115 DKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEI 174
D +QE IE + A + DE+ H+ L E D L S++
Sbjct: 180 DMSQEDIEPLLKN-MALHLKRLIDERDEHSETI-IELSEERDGLHFLPHASSSAQSPCGS 237
Query: 175 ELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK 234
ES L+ L ++ A + + +++ ++ ++L + ELE+ E+ R +++
Sbjct: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELE---EKTEQLLDCKQELEQMEIELKRLQQE 294
Query: 235 NTQL-------KRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN 287
N L + +EL+A LREK + L + + + + E+ ++E + DN
Sbjct: 295 NMNLLSDARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 288 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
Q L + L+ +E ++ R L K L+ L K+ D+
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 40.4 bits (93), Expect = 0.002
Identities = 43/226 (19%), Positives = 94/226 (41%), Gaps = 40/226 (17%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQASSVN------GTDDEKASHAGPANTHLKSENDKL 158
++K + +D EK++T ++ + G + E+ H +S +D+
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE------QSTDDRY 953
Query: 159 KIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKI 218
K+ ++ + +KK L+ E A L L+ES +Q +++ + + L+ +
Sbjct: 954 KLLESKLESTLKK---SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1010
Query: 219 DE----------------LEEQCSEINRE----KEKNTQLKRRIEELEAELREKETELKD 258
DE E + E RE K++ +++R L+AE + +T+LK
Sbjct: 1011 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1070
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
L Q+ + + + ++ + + QN + ++ K +E S
Sbjct: 1071 LETQNNNL-----QAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
Score = 39.7 bits (91), Expect = 0.004
Identities = 40/173 (23%), Positives = 75/173 (43%), Gaps = 18/173 (10%)
Query: 162 LTQSAANVKKWEIELQTLRESNARL------TTALQESAASVEQWKRQFSICRDENDRLR 215
L A + + + EL LRE R+ + +E +E +K + +++N L
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 216 NKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII--------- 266
LE+Q +K +L++ +L+A+L + E E RK+ E +
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 267 --PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKS 317
Q M E ++ +LE R ++ E +SL ++ E R LK+E+++
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT-SSRLLKLEMEN 469
Score = 38.5 bits (88), Expect = 0.009
Identities = 44/250 (17%), Positives = 102/250 (40%), Gaps = 21/250 (8%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPAN 148
E+ +T + Q + E+ + + Q ++ + S VN + N
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 208
L ++L+ + N K + + + N RL+ ++ + Q K+ C+
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASK----ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQL----KRRIEELEAELREK-----ETELKDL 259
+ + L + +LE+ + E+ ++ + + + LR++ E +KD+
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 260 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
K+++I+ + + E S KL E + + ++ ++ K E ++ + L L+
Sbjct: 586 EKENKILHESIKE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKEN 641
Query: 320 EVLDGKIDDL 329
E+L KI +L
Sbjct: 642 ELLQKKITNL 651
Score = 37.7 bits (86), Expect = 0.015
Identities = 57/277 (20%), Positives = 109/277 (39%), Gaps = 60/277 (21%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+QL K + ++ E +++ KDK Q + E QA + T +E G K+
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 154 ENDKLKIALTQSAANVKKWEIE--------------LQTLRESNA--------------R 185
+ ++ I +S +K+ E E L TLRE +
Sbjct: 869 LSKEIGI-YKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 186 LTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL 245
LT L++ + E+ D L +K++ ++ EI ++EK L+ R+EE
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI--KEEKIAALEARLEES 985
Query: 246 EAELREKETELKDLRKQSEIIPQLMSECEY---------------------------VSE 278
++ ELK ++K E + Q E V +
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1045
Query: 279 KLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
+L ER+N L+ + ++LKT +++ + + +L+ ++
Sbjct: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Score = 33.9 bits (76), Expect = 0.22
Identities = 39/172 (22%), Positives = 75/172 (43%), Gaps = 21/172 (12%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L END+L +Q E + L+ + L + L S + + +FS
Sbjct: 1242 LCGENDRLNHTYSQLLK-------ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS----- 1289
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEII 266
+L+ + +L+ +++N + E +QLK +EE L ++ L + L +Q+
Sbjct: 1290 --KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1347
Query: 267 PQL--MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 316
L + + +Y+ +KL R + LE+K+ + S R+R + LK
Sbjct: 1348 KDLFHVEQRQYI-DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK 1398
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 63.2 bits (152), Expect = 3e-10
Identities = 65/253 (25%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 104 QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 163
+E+ +I T+EK H QA +++K + A L+ + D L+ +L
Sbjct: 980 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE 1039
Query: 164 QSAANVKKWEIELQTLR---ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 220
Q KK ++L+ + E + +LT QES +E K+Q ++RL+ K E
Sbjct: 1040 QE----KKVRMDLERAKRKLEGDLKLT---QESIMDLENDKQQL------DERLKKKDFE 1086
Query: 221 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSECEYV 276
L + I E+ +QL+++++EL+A + E E EL+ R K ++ L E E +
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 277 SEKLEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK----SFLEVLDGK 325
SE+LE A N+ E + + ++ D+EE+ + L+ + L +
Sbjct: 1147 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206
Query: 326 IDDLHDFRRGLSK 338
ID+L ++ L K
Sbjct: 1207 IDNLQRVKQKLEK 1219
Score = 55.5 bits (132), Expect = 7e-08
Identities = 57/243 (23%), Positives = 113/243 (46%), Gaps = 35/243 (14%)
Query: 114 KDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWE 173
K + +E+++ + + A D + T K+E L+ L+++ + V +W
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE---LQRVLSKANSEVAQWR 1372
Query: 174 IELQT--------LRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQC 225
+ +T L E+ +L LQE+ +VE + S RL+N+I++L
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 226 SEINR------EKEKN-----TQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECE 274
N +K++N + K++ EE ++EL E+ K+ R S + +L + E
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL---ESSQKEARSLSTELFKLKNAYE 1489
Query: 275 YVSEKLEAAERDNQNLEDKVRSL--------KT--DIEESKYRQRHLKVELKSFLEVLDG 324
E LE +R+N+NL++++ L KT ++E+ + + K+EL+S LE +
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA 1549
Query: 325 KID 327
++
Sbjct: 1550 SLE 1552
Score = 48.1 bits (113), Expect = 1e-05
Identities = 52/257 (20%), Positives = 107/257 (41%), Gaps = 28/257 (10%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE---TSSNHSQASSVNGT--------DDEK 140
S +L + + Q VK+ K+ K+K++ K+E +SN Q +D+
Sbjct: 1199 SVAELGEQIDNLQRVKQ--KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 141 ASHAGPAN-------------THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLT 187
H A L++EN +L L + A + + T + L
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 188 TALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK-NTQLKRRIEELE 246
L+E + R + D LR + +E E +E+ R K N+++ + + E
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 247 AELREKETELKDLRKQ-SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
+ ++ EL++ +K+ ++ + + E V+ K + E+ L++++ L D+E S
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436
Query: 306 YRQRHLKVELKSFLEVL 322
L + ++F ++L
Sbjct: 1437 AAAAALDKKQRNFDKIL 1453
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/208 (25%), Positives = 103/208 (49%), Gaps = 32/208 (15%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARL---TTALQESAASVEQWKRQF--- 204
+K E +LK AL +S A K+ E ++ +L + L A Q++ A E+ Q
Sbjct: 852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911
Query: 205 -----SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAEL----REK--- 252
+ ++ N+RL ++ + E ++ + +++ ++LKR I++LE L +EK
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 253 ETELKDLRKQ----SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK---------- 298
E ++K+L ++ EII +L E + + E + A D Q EDKV +L
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 299 TDIEESKYRQRHLKVELKSFLEVLDGKI 326
D+E S +++ ++++L+ L+G +
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDL 1059
Score = 47.4 bits (111), Expect = 2e-05
Identities = 55/274 (20%), Positives = 118/274 (43%), Gaps = 50/274 (18%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
+ +L + ++ + + K+A+ QE IETS E+ NT L
Sbjct: 1682 QAELEELRAVVEQTERSRKLAE---QELIETS--------------ERVQLLHSQNTSLI 1724
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ K+ L+Q V++ +Q R + + A+ ++A E+ K++ +D +
Sbjct: 1725 NQKKKMDADLSQLQTEVEE---AVQECRNAEEKAKKAITDAAMMAEELKKE----QDTSA 1777
Query: 213 RLRNKIDELEEQCSEINREKEKNTQL-----KRRIEELEAELREKETELK-DLRKQSEII 266
L +E+ ++ ++ Q+ K+++++LEA +RE E EL+ + ++ +E +
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 267 PQLMSECEYVSEKLEAAERDNQNL----------EDKVRSLKTDIEE---------SKYR 307
+ + E E D +NL + KV++ K EE SK+R
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1897
Query: 308 Q-RHLKVELKSFLEVLDGKIDDLHDFRRGLSKLG 340
+ +H E + ++ + +++ L R + G
Sbjct: 1898 KVQHELDEAEERADIAESQVNKLRAKSRDIGTKG 1931
Score = 42.7 bits (99), Expect = 5e-04
Identities = 57/290 (19%), Positives = 116/290 (40%), Gaps = 36/290 (12%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNH 127
+K + + QW E+ K A++ QE +EA + K +E + +
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS-LEKTKHR 1420
Query: 128 SQASSVNGTDDEKASHAGPANTHLKSEN-DKL----KIALTQSAANVKKWEIELQTLRES 182
Q + D + S+A A K N DK+ K +S + ++ + E ++L
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 183 NARLTTALQESAASVEQWKRQFSICRDENDRLRNK-------IDELEEQCSEINREK--- 232
+L A +ES +E +KR+ ++E L + I ELE+ ++ EK
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 233 -------------EKNTQLKRRIE--ELEAE----LREKETELKDL-RKQSEIIPQLMSE 272
E+ L+ ++E +++AE L EK+ E++ R ++ L +
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 273 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 322
+ + A R + +E + ++ + + + ++KS +L
Sbjct: 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Score = 41.2 bits (95), Expect = 0.001
Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 28/256 (10%)
Query: 98 KFAEKFQEVKEAAK-----IAKDKTQEKIETSSNHSQA---SSVNGTDDE---KASHAG- 145
K AEK +E+++A + + +T ET S + + G +E + SHA
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANR 1634
Query: 146 ---PANTHLKSENDKLK---IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 199
A +KS LK I L + + + + N L L+E A VEQ
Sbjct: 1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1694
Query: 200 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKN----TQLKRRIEELEAELREKETE 255
+R + E ++ L Q + + +K+K +QL+ +EE E R E +
Sbjct: 1695 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
K + ++ + + + + S L ER +N+E ++ L+ ++E++ Q LK
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHL---ERMKKNMEQTIKDLQHRLDEAE--QIALKGGK 1809
Query: 316 KSFLEVLDGKIDDLHD 331
K L+ L+ ++ +L +
Sbjct: 1810 KQ-LQKLEARVRELEN 1824
Score = 30.4 bits (67), Expect = 2.4
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 6/113 (5%)
Query: 220 ELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEK 279
E+ E R KE + + R +ELE ++ E DL+ Q + +++ E E+
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE---ER 904
Query: 280 LEAAERDNQNLEDKVRSLKTDIEESKYRQRHL---KVELKSFLEVLDGKIDDL 329
+ ++ LE KV+ + +E+ + L K +L+ L IDDL
Sbjct: 905 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL 957
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/274 (20%), Positives = 119/274 (43%), Gaps = 22/274 (8%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKF----QEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
+ +V G+ +E + K A+ ++++ ++ +++T++K+ S+ Q
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 136 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNAR-------LTT 188
+ ++ A +L+ L I L+ S ++ + ++ L E R LT
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 189 ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL--- 245
+E AA+ ++ ++ + + E D L +D + S + +++ K QL + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 246 --------EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 297
EAE REKET+ L + E + E E ++ L+A D + +D V
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 298 KTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 331
++E+SK E+K+ LE L+ ++ D
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/232 (24%), Positives = 103/232 (44%), Gaps = 17/232 (7%)
Query: 93 EQQLTKFAEKFQEVKE-AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E++ KF + E K ++K A ++ + + E ++A S+ +E A A L
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE----ALEAKEEL 1502
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+ N LK + ++ + L +S L T ++E +E+ + + D
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
RL + L+ Q + +++ + KRR +L+ +L E ETEL+D RKQ +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQRQLHEYETELEDERKQRAL------ 1614
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
+KLE D ++LE + S EE+ + R L+ ++K F L+
Sbjct: 1615 -AAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Score = 52.0 bits (123), Expect = 8e-07
Identities = 54/246 (21%), Positives = 113/246 (45%), Gaps = 31/246 (12%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
Q+T+ E+ Q ++ + K++ Q E E HSQ + E+ A T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----AETE 901
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L +E +++++ L KK E+E + L E ARL E+ + + + E
Sbjct: 902 LYAEAEEMRVRLA-----AKKQELE-EILHEMEARL-----------EEEEDRGQQLQAE 944
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKR-----RIEELEAELREKETELKDLRKQSEI 265
++ ++ +LEEQ E ++K QL++ +I++LE E+ + + L K+ ++
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK 325
+ + +S+ + E ++ L++K S+ +++E ++ + EL+ L+G
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 326 IDDLHD 331
D H+
Sbjct: 1064 ASDFHE 1069
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
S E L + E + A K A + +E E + S S N DEK
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELA--SSLSGRNALQDEKRRLEARI-AQ 1740
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ E ++ + + + V+K + + L A + Q++ ++ +Q +RQ
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ------- 1793
Query: 211 NDRLRNKIDELEEQC-----SEINREKEKNTQLKRRIEELEAELREKETELKDLR----K 261
N LR+K+ E+E S I + K QL+ E++E E REK+ K L+ K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKK 1850
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
EI+ Q+ E + + E AE+ N +V+ LK +EE++ + + +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNA----RVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 322 LD 323
LD
Sbjct: 1907 LD 1908
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/196 (20%), Positives = 93/196 (47%), Gaps = 19/196 (9%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N L E L+ ++ N+ + E + + L + + + + E +++ ++
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS---- 1049
Query: 208 RDENDRLRNKID----ELEEQCSEINRE-KEKNTQLKRRIEELEA-------ELREKETE 255
R E ++L+ K++ + EQ +++ + E QL ++ EEL+A E+ +K
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE---ESKYRQRHLK 312
LK +R+ I L + + AE+ ++L +++ +LKT++E +S Q+ L+
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 313 VELKSFLEVLDGKIDD 328
+ + + VL +D+
Sbjct: 1170 AKREQEVTVLKKALDE 1185
Score = 45.1 bits (105), Expect = 9e-05
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 24/263 (9%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
++L QE ++ + A++K +++ +A +D S A K
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKR 1172
Query: 154 ENDK--LKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
E + LK AL + + E ++Q +R+ +A+ A++E +EQ+KR +
Sbjct: 1173 EQEVTVLKKALDEET---RSHEAQVQEMRQKHAQ---AVEELTEQLEQFKRAKANLDKNK 1226
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ-SEIIPQLM 270
L + +L + + + K++ K+++E EL+ K ++ + R + ++ + +L
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK--------------YRQRHLKVELK 316
+E E V+ L AE L V SL + +++++ + R L+ E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 317 SFLEVLDGKIDDLHDFRRGLSKL 339
S + LD +++ + R +S L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTL 1369
Score = 42.4 bits (98), Expect = 6e-04
Identities = 32/141 (22%), Positives = 68/141 (48%), Gaps = 4/141 (2%)
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 258
QW R F+ + R + +E++ + E+ + KE+ + + ++ELE + + E
Sbjct: 833 QWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 891
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSF 318
L++Q + +L +E E + +L A + Q LE+ + ++ +EE + R + L+ E K
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 319 LEVLDGKIDDLHDFRRGLSKL 339
+ + + L + KL
Sbjct: 949 AQQMLDLEEQLEEEEAARQKL 969
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/218 (21%), Positives = 96/218 (44%), Gaps = 27/218 (12%)
Query: 103 FQEVKEAAKIAKDK---TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
FQ E A+ ++D+ T ++ E + +A + +D A+ L+ E +
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
+A + S N + E + L A+L L+E ++E +DR+R
Sbjct: 1717 LASSLSGRNAL--QDEKRRLEARIAQLEEELEEEQGNMEAM----------SDRVRKATQ 1764
Query: 220 ELEEQCSEINREK---EKNTQLKRRIEELEAELREKETELKDLRK---QSEI------IP 267
+ E+ +E+ E+ +KN ++++E ELR K E++ K +S I I
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
QL + E + + +AA + + + K++ + +E+ +
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/171 (22%), Positives = 81/171 (47%), Gaps = 11/171 (6%)
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNA----RLTTALQESAASVEQWKRQFSICR 208
+E+ KL++ + A ++E +LQ E N +L L E +E ++Q ++
Sbjct: 1558 TEDAKLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+L + +LE Q + +E+ +++ +L+A++++ + EL+D R + I
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
E E ++ LEA D L++ + + + +++ + L EL S L
Sbjct: 1674 TAKENEKKAKSLEA---DLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Score = 38.1 bits (87), Expect = 0.012
Identities = 42/194 (21%), Positives = 77/194 (39%), Gaps = 27/194 (13%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E+Q + K E++ A K T +E ++ + + +++A A LK
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQLEEQVEQEAREKQAATKSLK 1845
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ KLK L Q K E + + NAR V+Q KRQ +E+
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR-----------VKQLKRQLEEAEEESQ 1894
Query: 213 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 272
R+ +L+ E++ E N + R + L+++LR ++ +P S
Sbjct: 1895 RINANRRKLQR---ELDEATESNEAMGREVNALKSKLRR--------GNETSFVPSRRSG 1943
Query: 273 CEYVSEKLEAAERD 286
V E + +E +
Sbjct: 1944 GRRVIENADGSEEE 1957
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/274 (20%), Positives = 119/274 (43%), Gaps = 22/274 (8%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKF----QEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
+ +V G+ +E + K A+ ++++ ++ +++T++K+ S+ Q
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 136 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNAR-------LTT 188
+ ++ A +L+ L I L+ S ++ + ++ L E R LT
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 189 ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL--- 245
+E AA+ ++ ++ + + E D L +D + S + +++ K QL + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 246 --------EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 297
EAE REKET+ L + E + E E ++ L+A D + +D V
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 298 KTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 331
++E+SK E+K+ LE L+ ++ D
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/232 (24%), Positives = 103/232 (44%), Gaps = 17/232 (7%)
Query: 93 EQQLTKFAEKFQEVKE-AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E++ KF + E K ++K A ++ + + E ++A S+ +E A A L
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE----ALEAKEEL 1509
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+ N LK + ++ + L +S L T ++E +E+ + + D
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
RL + L+ Q + +++ + KRR +L+ +L E ETEL+D RKQ +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQRQLHEYETELEDERKQRAL------ 1621
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
+KLE D ++LE + S EE+ + R L+ ++K F L+
Sbjct: 1622 -AAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Score = 52.0 bits (123), Expect = 8e-07
Identities = 54/246 (21%), Positives = 113/246 (45%), Gaps = 31/246 (12%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
Q+T+ E+ Q ++ + K++ Q E E HSQ + E+ A T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----AETE 908
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L +E +++++ L KK E+E + L E ARL E+ + + + E
Sbjct: 909 LYAEAEEMRVRLA-----AKKQELE-EILHEMEARL-----------EEEEDRGQQLQAE 951
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKR-----RIEELEAELREKETELKDLRKQSEI 265
++ ++ +LEEQ E ++K QL++ +I++LE E+ + + L K+ ++
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK 325
+ + +S+ + E ++ L++K S+ +++E ++ + EL+ L+G
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 326 IDDLHD 331
D H+
Sbjct: 1071 ASDFHE 1076
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
S E L + E + A K A + +E E + S S N DEK
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELA--SSLSGRNALQDEKRRLEARI-AQ 1747
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ E ++ + + + V+K + + L A + Q++ ++ +Q +RQ
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ------- 1800
Query: 211 NDRLRNKIDELEEQC-----SEINREKEKNTQLKRRIEELEAELREKETELKDLR----K 261
N LR+K+ E+E S I + K QL+ E++E E REK+ K L+ K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKK 1857
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
EI+ Q+ E + + E AE+ N +V+ LK +EE++ + + +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNA----RVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 322 LD 323
LD
Sbjct: 1914 LD 1915
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/196 (20%), Positives = 93/196 (47%), Gaps = 19/196 (9%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N L E L+ ++ N+ + E + + L + + + + E +++ ++
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS---- 1056
Query: 208 RDENDRLRNKID----ELEEQCSEINRE-KEKNTQLKRRIEELEA-------ELREKETE 255
R E ++L+ K++ + EQ +++ + E QL ++ EEL+A E+ +K
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE---ESKYRQRHLK 312
LK +R+ I L + + AE+ ++L +++ +LKT++E +S Q+ L+
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 313 VELKSFLEVLDGKIDD 328
+ + + VL +D+
Sbjct: 1177 AKREQEVTVLKKALDE 1192
Score = 45.1 bits (105), Expect = 9e-05
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 24/263 (9%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
++L QE ++ + A++K +++ +A +D S A K
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKR 1179
Query: 154 ENDK--LKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
E + LK AL + + E ++Q +R+ +A+ A++E +EQ+KR +
Sbjct: 1180 EQEVTVLKKALDEET---RSHEAQVQEMRQKHAQ---AVEELTEQLEQFKRAKANLDKNK 1233
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ-SEIIPQLM 270
L + +L + + + K++ K+++E EL+ K ++ + R + ++ + +L
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK--------------YRQRHLKVELK 316
+E E V+ L AE L V SL + +++++ + R L+ E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 317 SFLEVLDGKIDDLHDFRRGLSKL 339
S + LD +++ + R +S L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTL 1376
Score = 42.4 bits (98), Expect = 6e-04
Identities = 32/141 (22%), Positives = 68/141 (48%), Gaps = 4/141 (2%)
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 258
QW R F+ + R + +E++ + E+ + KE+ + + ++ELE + + E
Sbjct: 840 QWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 898
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSF 318
L++Q + +L +E E + +L A + Q LE+ + ++ +EE + R + L+ E K
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 319 LEVLDGKIDDLHDFRRGLSKL 339
+ + + L + KL
Sbjct: 956 AQQMLDLEEQLEEEEAARQKL 976
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/218 (21%), Positives = 96/218 (44%), Gaps = 27/218 (12%)
Query: 103 FQEVKEAAKIAKDK---TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
FQ E A+ ++D+ T ++ E + +A + +D A+ L+ E +
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
+A + S N + E + L A+L L+E ++E +DR+R
Sbjct: 1724 LASSLSGRNAL--QDEKRRLEARIAQLEEELEEEQGNMEAM----------SDRVRKATQ 1771
Query: 220 ELEEQCSEINREK---EKNTQLKRRIEELEAELREKETELKDLRK---QSEI------IP 267
+ E+ +E+ E+ +KN ++++E ELR K E++ K +S I I
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
QL + E + + +AA + + + K++ + +E+ +
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/171 (22%), Positives = 81/171 (47%), Gaps = 11/171 (6%)
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNA----RLTTALQESAASVEQWKRQFSICR 208
+E+ KL++ + A ++E +LQ E N +L L E +E ++Q ++
Sbjct: 1565 TEDAKLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+L + +LE Q + +E+ +++ +L+A++++ + EL+D R + I
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
E E ++ LEA D L++ + + + +++ + L EL S L
Sbjct: 1681 TAKENEKKAKSLEA---DLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Score = 38.1 bits (87), Expect = 0.012
Identities = 42/194 (21%), Positives = 77/194 (39%), Gaps = 27/194 (13%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E+Q + K E++ A K T +E ++ + + +++A A LK
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQLEEQVEQEAREKQAATKSLK 1852
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ KLK L Q K E + + NAR V+Q KRQ +E+
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR-----------VKQLKRQLEEAEEESQ 1901
Query: 213 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 272
R+ +L+ E++ E N + R + L+++LR ++ +P S
Sbjct: 1902 RINANRRKLQR---ELDEATESNEAMGREVNALKSKLRR--------GNETSFVPSRRSG 1950
Query: 273 CEYVSEKLEAAERD 286
V E + +E +
Sbjct: 1951 GRRVIENADGSEEE 1964
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/274 (20%), Positives = 119/274 (43%), Gaps = 22/274 (8%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKF----QEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
+ +V G+ +E + K A+ ++++ ++ +++T++K+ S+ Q
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 136 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNAR-------LTT 188
+ ++ A +L+ L I L+ S ++ + ++ L E R LT
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 189 ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL--- 245
+E AA+ ++ ++ + + E D L +D + S + +++ K QL + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 246 --------EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 297
EAE REKET+ L + E + E E ++ L+A D + +D V
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 298 KTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 331
++E+SK E+K+ LE L+ ++ D
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/232 (24%), Positives = 103/232 (44%), Gaps = 17/232 (7%)
Query: 93 EQQLTKFAEKFQEVKE-AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E++ KF + E K ++K A ++ + + E ++A S+ +E A A L
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE----ALEAKEEL 1509
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+ N LK + ++ + L +S L T ++E +E+ + + D
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
RL + L+ Q + +++ + KRR +L+ +L E ETEL+D RKQ +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQRQLHEYETELEDERKQRAL------ 1621
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
+KLE D ++LE + S EE+ + R L+ ++K F L+
Sbjct: 1622 -AAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Score = 52.0 bits (123), Expect = 8e-07
Identities = 54/246 (21%), Positives = 113/246 (45%), Gaps = 31/246 (12%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
Q+T+ E+ Q ++ + K++ Q E E HSQ + E+ A T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----AETE 908
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L +E +++++ L KK E+E + L E ARL E+ + + + E
Sbjct: 909 LYAEAEEMRVRLA-----AKKQELE-EILHEMEARL-----------EEEEDRGQQLQAE 951
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKR-----RIEELEAELREKETELKDLRKQSEI 265
++ ++ +LEEQ E ++K QL++ +I++LE E+ + + L K+ ++
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK 325
+ + +S+ + E ++ L++K S+ +++E ++ + EL+ L+G
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 326 IDDLHD 331
D H+
Sbjct: 1071 ASDFHE 1076
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
S E L + E + A K A + +E E + S S N DEK
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELA--SSLSGRNALQDEKRRLEARI-AQ 1747
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ E ++ + + + V+K + + L A + Q++ ++ +Q +RQ
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ------- 1800
Query: 211 NDRLRNKIDELEEQC-----SEINREKEKNTQLKRRIEELEAELREKETELKDLR----K 261
N LR+K+ E+E S I + K QL+ E++E E REK+ K L+ K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKK 1857
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
EI+ Q+ E + + E AE+ N +V+ LK +EE++ + + +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNA----RVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 322 LD 323
LD
Sbjct: 1914 LD 1915
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/196 (20%), Positives = 93/196 (47%), Gaps = 19/196 (9%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N L E L+ ++ N+ + E + + L + + + + E +++ ++
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS---- 1056
Query: 208 RDENDRLRNKID----ELEEQCSEINRE-KEKNTQLKRRIEELEA-------ELREKETE 255
R E ++L+ K++ + EQ +++ + E QL ++ EEL+A E+ +K
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE---ESKYRQRHLK 312
LK +R+ I L + + AE+ ++L +++ +LKT++E +S Q+ L+
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 313 VELKSFLEVLDGKIDD 328
+ + + VL +D+
Sbjct: 1177 AKREQEVTVLKKALDE 1192
Score = 45.1 bits (105), Expect = 9e-05
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 24/263 (9%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
++L QE ++ + A++K +++ +A +D S A K
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKR 1179
Query: 154 ENDK--LKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
E + LK AL + + E ++Q +R+ +A+ A++E +EQ+KR +
Sbjct: 1180 EQEVTVLKKALDEET---RSHEAQVQEMRQKHAQ---AVEELTEQLEQFKRAKANLDKNK 1233
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ-SEIIPQLM 270
L + +L + + + K++ K+++E EL+ K ++ + R + ++ + +L
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK--------------YRQRHLKVELK 316
+E E V+ L AE L V SL + +++++ + R L+ E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 317 SFLEVLDGKIDDLHDFRRGLSKL 339
S + LD +++ + R +S L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTL 1376
Score = 42.4 bits (98), Expect = 6e-04
Identities = 32/141 (22%), Positives = 68/141 (48%), Gaps = 4/141 (2%)
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 258
QW R F+ + R + +E++ + E+ + KE+ + + ++ELE + + E
Sbjct: 840 QWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 898
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSF 318
L++Q + +L +E E + +L A + Q LE+ + ++ +EE + R + L+ E K
Sbjct: 899 LQEQLQAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 319 LEVLDGKIDDLHDFRRGLSKL 339
+ + + L + KL
Sbjct: 956 AQQMLDLEEQLEEEEAARQKL 976
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/218 (21%), Positives = 96/218 (44%), Gaps = 27/218 (12%)
Query: 103 FQEVKEAAKIAKDK---TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
FQ E A+ ++D+ T ++ E + +A + +D A+ L+ E +
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
+A + S N + E + L A+L L+E ++E +DR+R
Sbjct: 1724 LASSLSGRNAL--QDEKRRLEARIAQLEEELEEEQGNMEAM----------SDRVRKATQ 1771
Query: 220 ELEEQCSEINREK---EKNTQLKRRIEELEAELREKETELKDLRK---QSEI------IP 267
+ E+ +E+ E+ +KN ++++E ELR K E++ K +S I I
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
QL + E + + +AA + + + K++ + +E+ +
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/171 (22%), Positives = 81/171 (47%), Gaps = 11/171 (6%)
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNA----RLTTALQESAASVEQWKRQFSICR 208
+E+ KL++ + A ++E +LQ E N +L L E +E ++Q ++
Sbjct: 1565 TEDAKLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+L + +LE Q + +E+ +++ +L+A++++ + EL+D R + I
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
E E ++ LEA D L++ + + + +++ + L EL S L
Sbjct: 1681 TAKENEKKAKSLEA---DLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Score = 37.4 bits (85), Expect = 0.020
Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 19/158 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E+Q + K E++ A K T +E ++ + + +++A A LK
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQLEEQVEQEAREKQAATKSLK 1852
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ KLK L Q K E + + NAR V+Q KRQ +E+
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR-----------VKQLKRQLEEAEEESQ 1901
Query: 213 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELR 250
R+ +L+ E++ E N + R + L+++LR
Sbjct: 1902 RINANRRKLQR---ELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/274 (20%), Positives = 119/274 (43%), Gaps = 22/274 (8%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKF----QEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
+ +V G+ +E + K A+ ++++ ++ +++T++K+ S+ Q
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 136 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNAR-------LTT 188
+ ++ A +L+ L I L+ S ++ + ++ L E R LT
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 189 ALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL--- 245
+E AA+ ++ ++ + + E D L +D + S + +++ K QL + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 246 --------EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 297
EAE REKET+ L + E + E E ++ L+A D + +D V
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 298 KTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 331
++E+SK E+K+ LE L+ ++ D
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Score = 54.7 bits (130), Expect = 1e-07
Identities = 56/232 (24%), Positives = 103/232 (44%), Gaps = 17/232 (7%)
Query: 93 EQQLTKFAEKFQEVKE-AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E++ KF + E K ++K A ++ + + E ++A S+ +E A A L
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE----ALEAKEEL 1502
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+ N LK + ++ + L +S L T ++E +E+ + + D
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
RL + L+ Q + +++ + KRR +L+ +L E ETEL+D RKQ +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRR--QLQRQLHEYETELEDERKQRAL------ 1614
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
+KLE D ++LE + S EE+ + R L+ ++K F L+
Sbjct: 1615 -AAAAKKKLEG---DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Score = 52.0 bits (123), Expect = 8e-07
Identities = 54/246 (21%), Positives = 113/246 (45%), Gaps = 31/246 (12%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQ----EKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
Q+T+ E+ Q ++ + K++ Q E E HSQ + E+ A T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ----AETE 901
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L +E +++++ L KK E+E + L E ARL E+ + + + E
Sbjct: 902 LYAEAEEMRVRLA-----AKKQELE-EILHEMEARL-----------EEEEDRGQQLQAE 944
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKR-----RIEELEAELREKETELKDLRKQSEI 265
++ ++ +LEEQ E ++K QL++ +I++LE E+ + + L K+ ++
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQK-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK 325
+ + +S+ + E ++ L++K S+ +++E ++ + EL+ L+G
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 326 IDDLHD 331
D H+
Sbjct: 1064 ASDFHE 1069
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 26/242 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
S E L + E + A K A + +E E + S S N DEK
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELA--SSLSGRNALQDEKRRLEARI-AQ 1740
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ E ++ + + + V+K + + L A + Q++ ++ +Q +RQ
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ------- 1793
Query: 211 NDRLRNKIDELEEQC-----SEINREKEKNTQLKRRIEELEAELREKETELKDLR----K 261
N LR+K+ E+E S I + K QL+ E++E E REK+ K L+ K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE---EQVEQEAREKQAATKSLKQKDKK 1850
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
EI+ Q+ E + + E AE+ N +V+ LK +EE++ + + +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNA----RVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 322 LD 323
LD
Sbjct: 1907 LD 1908
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/196 (20%), Positives = 93/196 (47%), Gaps = 19/196 (9%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N L E L+ ++ N+ + E + + L + + + + E +++ ++
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS---- 1049
Query: 208 RDENDRLRNKID----ELEEQCSEINRE-KEKNTQLKRRIEELEA-------ELREKETE 255
R E ++L+ K++ + EQ +++ + E QL ++ EEL+A E+ +K
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE---ESKYRQRHLK 312
LK +R+ I L + + AE+ ++L +++ +LKT++E +S Q+ L+
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 313 VELKSFLEVLDGKIDD 328
+ + + VL +D+
Sbjct: 1170 AKREQEVTVLKKALDE 1185
Score = 45.1 bits (105), Expect = 9e-05
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 24/263 (9%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
++L QE ++ + A++K +++ +A +D S A K
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKR 1172
Query: 154 ENDK--LKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
E + LK AL + + E ++Q +R+ +A+ A++E +EQ+KR +
Sbjct: 1173 EQEVTVLKKALDEET---RSHEAQVQEMRQKHAQ---AVEELTEQLEQFKRAKANLDKNK 1226
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ-SEIIPQLM 270
L + +L + + + K++ K+++E EL+ K ++ + R + ++ + +L
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK--------------YRQRHLKVELK 316
+E E V+ L AE L V SL + +++++ + R L+ E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 317 SFLEVLDGKIDDLHDFRRGLSKL 339
S + LD +++ + R +S L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTL 1369
Score = 42.4 bits (98), Expect = 6e-04
Identities = 32/141 (22%), Positives = 68/141 (48%), Gaps = 4/141 (2%)
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 258
QW R F+ + R + +E++ + E+ + KE+ + + ++ELE + + E
Sbjct: 833 QWWRLFTKVKPLLQVTRQE-EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL 891
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSF 318
L++Q + +L +E E + +L A + Q LE+ + ++ +EE + R + L+ E K
Sbjct: 892 LQEQLQAETELYAEAEEMRVRLAAKK---QELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 319 LEVLDGKIDDLHDFRRGLSKL 339
+ + + L + KL
Sbjct: 949 AQQMLDLEEQLEEEEAARQKL 969
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/218 (21%), Positives = 96/218 (44%), Gaps = 27/218 (12%)
Query: 103 FQEVKEAAKIAKDK---TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
FQ E A+ ++D+ T ++ E + +A + +D A+ L+ E +
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
+A + S N + E + L A+L L+E ++E +DR+R
Sbjct: 1717 LASSLSGRNAL--QDEKRRLEARIAQLEEELEEEQGNMEAM----------SDRVRKATQ 1764
Query: 220 ELEEQCSEINREK---EKNTQLKRRIEELEAELREKETELKDLRK---QSEI------IP 267
+ E+ +E+ E+ +KN ++++E ELR K E++ K +S I I
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
QL + E + + +AA + + + K++ + +E+ +
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/171 (22%), Positives = 81/171 (47%), Gaps = 11/171 (6%)
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNA----RLTTALQESAASVEQWKRQFSICR 208
+E+ KL++ + A ++E +LQ E N +L L E +E ++Q ++
Sbjct: 1558 TEDAKLRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+L + +LE Q + +E+ +++ +L+A++++ + EL+D R + I
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
E E ++ LEA D L++ + + + +++ + L EL S L
Sbjct: 1674 TAKENEKKAKSLEA---DLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Score = 37.4 bits (85), Expect = 0.020
Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 19/158 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E+Q + K E++ A K T +E ++ + + +++A A LK
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALE-----AKIAQLEEQVEQEAREKQAATKSLK 1845
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ KLK L Q K E + + NAR V+Q KRQ +E+
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR-----------VKQLKRQLEEAEEESQ 1894
Query: 213 RLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELR 250
R+ +L+ E++ E N + R + L+++LR
Sbjct: 1895 RINANRRKLQR---ELDEATESNEAMGREVNALKSKLR 1929
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 60.1 bits (144), Expect = 3e-09
Identities = 52/226 (23%), Positives = 107/226 (47%), Gaps = 14/226 (6%)
Query: 94 QQLTKFAEKF---QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
++L K A+K Q ++A +I + T+EK ET ++ N + N
Sbjct: 1027 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1086
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNAR----LTTALQESAASVEQWKRQ--- 203
E +K K LT ++++ E++TL+++ A+ L+ +E+ E+ R
Sbjct: 1087 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE 1146
Query: 204 ---FSICRDENDRLRNKIDELEEQCSEINREK-EKNTQLKRRIEELEAELREKETELKDL 259
+E L N++ E++++ S+ ++ E+ L++ I A L EK+ EL+ L
Sbjct: 1147 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1206
Query: 260 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
R + ++ + + + ++ E D LE KV++L+ ++E+K
Sbjct: 1207 RNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENK 1252
Score = 50.8 bits (120), Expect = 2e-06
Identities = 57/239 (23%), Positives = 109/239 (45%), Gaps = 29/239 (12%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQ---ASSVNGTDDEKASHAGPAN 148
+EQ + A+K +E K+ + ++K+ETS N Q A T + K H
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999
Query: 149 THLKS---ENDKLKIALTQSAANVKKWEIELQTLRE--SNARLTTALQESAASVEQWKRQ 203
K+ DKLK A +++ ++ EL+ LR+ A+ +++ +EQ ++
Sbjct: 1000 NLQKTLLDTEDKLKGAREENSGLLQ----ELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055
Query: 204 -------FSICRDENDRLRNKIDELEE----QCSEINREKEKNTQLKRRIEELEAELREK 252
+ N +L+N++D L+E E+N+ KE T +++EE E+
Sbjct: 1056 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI--- 1112
Query: 253 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERD---NQNLEDKVRSLKTDIEESKYRQ 308
ET + ++S+ + L E ++E+L + + +Q LE++ L + E K R+
Sbjct: 1113 ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1171
Score = 48.9 bits (115), Expect = 7e-06
Identities = 44/217 (20%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTD-DEKASHAGPANTHL 151
E+Q + ++++E + K +EK E +A D E +G ++ L
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 898
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
ND+L++ +V++ +++L E+ + L ++++ EQ +++ + +E
Sbjct: 899 TKMNDELRL----KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 954
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
+ ELE + S++ ++ E + + +EL+A +E K K EI+ L
Sbjct: 955 KK------ELERKLSDLEKKMETS---HNQCQELKARYERATSETKT--KHEEILQNLQK 1003
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQ 308
+KL+ A +N L ++ L+ +++K Q
Sbjct: 1004 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1040
Score = 47.0 bits (110), Expect = 2e-05
Identities = 59/284 (20%), Positives = 124/284 (43%), Gaps = 39/284 (13%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT----QEKIET 123
T + FG ++ + L +++ ++L+K E + E A + K+ET
Sbjct: 525 TSLKEHFGAREETHQKEIKAL-YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 124 S-SNHSQA------SSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEI-- 174
+ ++H QA S G E A A LK++ +K+++ N++ +
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFA-----ELKTQIEKMRLDYQHEIENLQNQQDSE 638
Query: 175 ------ELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN----DRLRNKIDELEEQ 224
E++ LR A+L ++E S+E + + D++ + NK+ E E +
Sbjct: 639 RAAHAKEMEALR---AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695
Query: 225 CSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE 284
E+ + K + + I+ ++L+ E +L DL + + SE + + ++LEAAE
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755
Query: 285 RDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
+ ++LE K S+ +++ + + +L+ L +V
Sbjct: 756 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Score = 45.4 bits (106), Expect = 7e-05
Identities = 58/254 (22%), Positives = 108/254 (42%), Gaps = 23/254 (9%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDE--------KASHA 144
E L K E +VKE ++ + K E+ + N + S + T+++ KAS
Sbjct: 683 EDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFT--SQLKATEEKLLDLDALRKASSE 739
Query: 145 GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQF 204
G KSE KL+ L + +K EIE + +T LQ + +
Sbjct: 740 G------KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
S + L ++ L+E+ +E + E+ ++R ++E +L +KE + L E
Sbjct: 794 SEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 265 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 324
+ + +++ E ++ E ER+ Q ++ K L+ DI E +L + L
Sbjct: 851 KLRENLADME--AKFREKDEREEQLIKAK-EKLENDIAEIMKMSGDNSSQLTKMNDELRL 907
Query: 325 KIDDLHDFRRGLSK 338
K D+ + + L+K
Sbjct: 908 KERDVEELQLKLTK 921
Score = 45.4 bits (106), Expect = 7e-05
Identities = 53/243 (21%), Positives = 110/243 (45%), Gaps = 25/243 (10%)
Query: 101 EKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
+K ++ EAA+ K +IE ++ S+ASS+ + LK N L+
Sbjct: 745 KKLRQQLEAAE--KQIKHLEIEKNAESSKASSITRELQGR---------ELKLTN--LQE 791
Query: 161 ALTQSAANVKKWEIELQTLRESNARLTT-------ALQESAASVEQWKRQFSICRDENDR 213
L++ + + E ELQ L+E A + ++QE+ + Q + QF++ + ++
Sbjct: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 851
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE-LKDLRKQSEIIPQLMSE 272
LR + ++E + E + +E+ + K ++E AE+ + + L K ++ + +
Sbjct: 852 LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD 911
Query: 273 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKY----RQRHLKVELKSFLEVLDGKIDD 328
E + KL A + L+ + + E+S+ + K EL+ L L+ K++
Sbjct: 912 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971
Query: 329 LHD 331
H+
Sbjct: 972 SHN 974
Score = 39.7 bits (91), Expect = 0.004
Identities = 44/197 (22%), Positives = 83/197 (42%), Gaps = 26/197 (13%)
Query: 122 ETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRE 181
ETSS +++ S E L +E D + + ++ ++V + E EL R+
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD 397
Query: 182 SNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNT----- 236
+ + L+ A ++Q + E L N+++E + + ++ E+ +
Sbjct: 398 GHDQHVLELE---AKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
Query: 237 ------QLKRRIEELEAELREKETELKDLRKQSE---------IIPQLMSECEYVSEKLE 281
K RI ELE +L + E+ +LR++ E + L+ E + EKLE
Sbjct: 455 LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE 514
Query: 282 AAERDNQNLEDKVRSLK 298
D+Q ++ SLK
Sbjct: 515 VTRTDHQR---EITSLK 528
Score = 37.0 bits (84), Expect = 0.026
Identities = 45/180 (25%), Positives = 74/180 (41%), Gaps = 28/180 (15%)
Query: 107 KEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSA 166
K +K KD +EK + S S++ D + T L+ EN
Sbjct: 1169 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGEN----------- 1217
Query: 167 ANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC-------RDENDRLR-NKI 218
A+ K +QTL +L ++ +++ KRQ S DE++R + ++I
Sbjct: 1218 ASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI 1277
Query: 219 DELEEQCSEINREKEKNTQLKRRIEEL-EAELREKETELK-----DLRKQSEIIPQLMSE 272
D L ++ R KN LK ++E + EA L +L D KQS+ P+L +
Sbjct: 1278 DFLNSVIVDLQR---KNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD 1334
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 60.1 bits (144), Expect = 3e-09
Identities = 52/226 (23%), Positives = 107/226 (47%), Gaps = 14/226 (6%)
Query: 94 QQLTKFAEKF---QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
++L K A+K Q ++A +I + T+EK ET ++ N + N
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNAR----LTTALQESAASVEQWKRQ--- 203
E +K K LT ++++ E++TL+++ A+ L+ +E+ E+ R
Sbjct: 1122 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE 1181
Query: 204 ---FSICRDENDRLRNKIDELEEQCSEINREK-EKNTQLKRRIEELEAELREKETELKDL 259
+E L N++ E++++ S+ ++ E+ L++ I A L EK+ EL+ L
Sbjct: 1182 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1241
Query: 260 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
R + ++ + + + ++ E D LE KV++L+ ++E+K
Sbjct: 1242 RNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENK 1287
Score = 50.8 bits (120), Expect = 2e-06
Identities = 57/239 (23%), Positives = 109/239 (45%), Gaps = 29/239 (12%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQ---ASSVNGTDDEKASHAGPAN 148
+EQ + A+K +E K+ + ++K+ETS N Q A T + K H
Sbjct: 975 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1034
Query: 149 THLKS---ENDKLKIALTQSAANVKKWEIELQTLRE--SNARLTTALQESAASVEQWKRQ 203
K+ DKLK A +++ ++ EL+ LR+ A+ +++ +EQ ++
Sbjct: 1035 NLQKTLLDTEDKLKGAREENSGLLQ----ELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090
Query: 204 -------FSICRDENDRLRNKIDELEE----QCSEINREKEKNTQLKRRIEELEAELREK 252
+ N +L+N++D L+E E+N+ KE T +++EE E+
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI--- 1147
Query: 253 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERD---NQNLEDKVRSLKTDIEESKYRQ 308
ET + ++S+ + L E ++E+L + + +Q LE++ L + E K R+
Sbjct: 1148 ETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1206
Score = 48.9 bits (115), Expect = 7e-06
Identities = 44/217 (20%), Positives = 97/217 (44%), Gaps = 16/217 (7%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTD-DEKASHAGPANTHL 151
E+Q + ++++E + K +EK E +A D E +G ++ L
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
ND+L++ +V++ +++L E+ + L ++++ EQ +++ + +E
Sbjct: 934 TKMNDELRL----KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 989
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
+ ELE + S++ ++ E + + +EL+A +E K K EI+ L
Sbjct: 990 KK------ELERKLSDLEKKMETS---HNQCQELKARYERATSETKT--KHEEILQNLQK 1038
Query: 272 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQ 308
+KL+ A +N L ++ L+ +++K Q
Sbjct: 1039 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1075
Score = 47.0 bits (110), Expect = 2e-05
Identities = 59/284 (20%), Positives = 124/284 (43%), Gaps = 39/284 (13%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT----QEKIET 123
T + FG ++ + L +++ ++L+K E + E A + K+ET
Sbjct: 560 TSLKEHFGAREETHQKEIKAL-YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 124 S-SNHSQA------SSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEI-- 174
+ ++H QA S G E A A LK++ +K+++ N++ +
Sbjct: 619 AIASHQQAMEELKVSFSKGLGTETAEFA-----ELKTQIEKMRLDYQHEIENLQNQQDSE 673
Query: 175 ------ELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN----DRLRNKIDELEEQ 224
E++ LR A+L ++E S+E + + D++ + NK+ E E +
Sbjct: 674 RAAHAKEMEALR---AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
Query: 225 CSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE 284
E+ + K + + I+ ++L+ E +L DL + + SE + + ++LEAAE
Sbjct: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 790
Query: 285 RDNQNLE-------DKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
+ ++LE K S+ +++ + + +L+ L +V
Sbjct: 791 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
Score = 45.4 bits (106), Expect = 7e-05
Identities = 58/254 (22%), Positives = 108/254 (42%), Gaps = 23/254 (9%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDE--------KASHA 144
E L K E +VKE ++ + K E+ + N + S + T+++ KAS
Sbjct: 718 EDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFT--SQLKATEEKLLDLDALRKASSE 774
Query: 145 GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQF 204
G KSE KL+ L + +K EIE + +T LQ + +
Sbjct: 775 G------KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 264
S + L ++ L+E+ +E + E+ ++R ++E +L +KE + L E
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 885
Query: 265 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 324
+ + +++ E ++ E ER+ Q ++ K L+ DI E +L + L
Sbjct: 886 KLRENLADME--AKFREKDEREEQLIKAK-EKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
Query: 325 KIDDLHDFRRGLSK 338
K D+ + + L+K
Sbjct: 943 KERDVEELQLKLTK 956
Score = 45.4 bits (106), Expect = 7e-05
Identities = 53/243 (21%), Positives = 110/243 (45%), Gaps = 25/243 (10%)
Query: 101 EKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
+K ++ EAA+ K +IE ++ S+ASS+ + LK N L+
Sbjct: 780 KKLRQQLEAAE--KQIKHLEIEKNAESSKASSITRELQGR---------ELKLTN--LQE 826
Query: 161 ALTQSAANVKKWEIELQTLRESNARLTT-------ALQESAASVEQWKRQFSICRDENDR 213
L++ + + E ELQ L+E A + ++QE+ + Q + QF++ + ++
Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE-LKDLRKQSEIIPQLMSE 272
LR + ++E + E + +E+ + K ++E AE+ + + L K ++ + +
Sbjct: 887 LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD 946
Query: 273 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKY----RQRHLKVELKSFLEVLDGKIDD 328
E + KL A + L+ + + E+S+ + K EL+ L L+ K++
Sbjct: 947 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 1006
Query: 329 LHD 331
H+
Sbjct: 1007 SHN 1009
Score = 41.2 bits (95), Expect = 0.001
Identities = 61/236 (25%), Positives = 105/236 (44%), Gaps = 30/236 (12%)
Query: 73 KFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASS 132
K+G +A + V +GF S A + V + ++ SS S ASS
Sbjct: 268 KYGLFAP--VHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASS 325
Query: 133 VNGTDDEKASHAGPANTHLKSENDKL---KIALT---QSAANVKKWEIELQTLRESNARL 186
V+ P+ T L +E KI+ T Q A K+ IE Q L E +
Sbjct: 326 VSSR---------PSRTGLLTETSSRYARKISGTTALQEALKEKQQHIE-QLLAERDLE- 374
Query: 187 TTALQESAASVEQWKRQFSICRDENDR----LRNKIDELEEQCSEINREK-EKNTQL--- 238
+ ++ + V + +++ ++ RD +D+ L K+D+L +REK E QL
Sbjct: 375 RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEE 434
Query: 239 KRRIEELEAELREKETELKDLRKQSEIIPQLMSECE--YVSEKLEAAERDNQNLED 292
KR++E+L+ + E+ DL Q+++ + E E + EK + A++ + LED
Sbjct: 435 KRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTK-ADKLQRELED 489
Score = 37.0 bits (84), Expect = 0.026
Identities = 45/180 (25%), Positives = 74/180 (41%), Gaps = 28/180 (15%)
Query: 107 KEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSA 166
K +K KD +EK + S S++ D + T L+ EN
Sbjct: 1204 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGEN----------- 1252
Query: 167 ANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC-------RDENDRLR-NKI 218
A+ K +QTL +L ++ +++ KRQ S DE++R + ++I
Sbjct: 1253 ASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI 1312
Query: 219 DELEEQCSEINREKEKNTQLKRRIEEL-EAELREKETELK-----DLRKQSEIIPQLMSE 272
D L ++ R KN LK ++E + EA L +L D KQS+ P+L +
Sbjct: 1313 DFLNSVIVDLQR---KNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD 1369
Score = 32.7 bits (73), Expect = 0.48
Identities = 50/231 (21%), Positives = 88/231 (38%), Gaps = 37/231 (16%)
Query: 97 TKFAEKFQEVKEAAKIAKDKTQ--EKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSE 154
+++A K + K+K Q E++ + +A T SH G L
Sbjct: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKAT-----SHVGEIEQELALA 395
Query: 155 NDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWK---RQFSICRDEN 211
D + + A + + ++ L L+E VE + + SI + +
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 212 DRLRN----KIDELEE-------QCSEINREKEKN----TQLKRRIEELEAELREKETEL 256
+ +I ELE+ + ++ RE E K RI ELE +L + E+
Sbjct: 456 ETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEV 515
Query: 257 KDLRKQSE---------IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK 298
+LR++ E + L+ E + EKLE D+Q ++ SLK
Sbjct: 516 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR---EITSLK 563
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 59.3 bits (142), Expect = 5e-09
Identities = 62/253 (24%), Positives = 116/253 (45%), Gaps = 31/253 (12%)
Query: 104 QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 163
+E+ +I T+EK H QA +++K + + L+ + D L+ +L
Sbjct: 982 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLE 1041
Query: 164 QSAANVKKWEIELQTLR---ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 220
Q KK ++L+ + E + +LT QES +E K Q ++L+ K +
Sbjct: 1042 QE----KKVRMDLERAKRKLEGDLKLT---QESIMDLENDKLQLE------EKLKKKEFD 1088
Query: 221 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSECEYV 276
+ +Q S+I E+ QL+++++E +A + E E EL+ R K ++ L E E +
Sbjct: 1089 INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1148
Query: 277 SEKLEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK----SFLEVLDGK 325
SE+LE A N+ E + + ++ D+EE+ + L+ + L +
Sbjct: 1149 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1208
Query: 326 IDDLHDFRRGLSK 338
ID+L ++ L K
Sbjct: 1209 IDNLQRVKQKLEK 1221
Score = 53.9 bits (128), Expect = 2e-07
Identities = 48/200 (24%), Positives = 93/200 (46%), Gaps = 32/200 (16%)
Query: 157 KLKIALTQSAANVKKWEIELQT--------LRESNARLTTALQESAASVEQWKRQFSICR 208
+L+ L+++ + V +W + +T L E+ +L LQ++ +VE + S
Sbjct: 1358 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLE 1417
Query: 209 DENDRLRNKIDELEEQCSEINR------EKEKN-----TQLKRRIEELEAELREKETELK 257
RL+N+I++L N +K++N + K++ EE ++EL E+ K
Sbjct: 1418 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL---ESSQK 1474
Query: 258 DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHL------ 311
+ R S + +L + E E LE +R+N+NL++++ L + E L
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQ 1534
Query: 312 ----KVELKSFLEVLDGKID 327
K+EL+S LE + ++
Sbjct: 1535 LEVEKLELQSALEEAEASLE 1554
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/229 (20%), Positives = 103/229 (44%), Gaps = 40/229 (17%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
+ +L + ++ + + K+A+ QE IETS E+ NT L
Sbjct: 1684 QAELEELRAVVEQTERSRKLAE---QELIETS--------------ERVQLLHSQNTSLI 1726
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEND 212
++ K++ LTQ + V++ +Q R + + A+ ++A E+ K++ +D +
Sbjct: 1727 NQKKKMESDLTQLQSEVEE---AVQECRNAEEKAKKAITDAAMMAEELKKE----QDTSA 1779
Query: 213 RLRNKIDELEEQCSEINREKEKNTQL-----KRRIEELEAELREKETELK-DLRKQSEII 266
L +E+ ++ ++ Q+ K+++++LEA +RE E EL+ + ++ +E +
Sbjct: 1780 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESV 1839
Query: 267 PQLMSECEYVSEKLEAAERDNQNL----------EDKVRSLKTDIEESK 305
+ + E E D +NL + KV++ K EE++
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1888
Score = 45.4 bits (106), Expect = 7e-05
Identities = 36/186 (19%), Positives = 86/186 (46%), Gaps = 16/186 (8%)
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 208
+ LK + D L++ L + E +++ L E A L E A + + K+
Sbjct: 950 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDEIIAKLTKEKKALQEAH 1005
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+ +D+L+ + ++N + +L++++++LE L +++ DL + +
Sbjct: 1006 QQ------ALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR---K 1056
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYR---QRHLKVELKSFLEVLDGK 325
L + + E + E D LE+K++ + DI + + ++ L ++L+ L+ +
Sbjct: 1057 LEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQAR 1116
Query: 326 IDDLHD 331
I++L +
Sbjct: 1117 IEELEE 1122
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/208 (24%), Positives = 98/208 (47%), Gaps = 32/208 (15%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
+K E ++K L +S A K+ E ++ +L + L +Q ++ + +
Sbjct: 854 MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKN 913
Query: 211 NDRLRNKIDELEEQCS---EINRE--------KEKNTQLKRRIEELEAEL----REK--- 252
+L K+ E+ E+ E+N E +++ ++LK+ I++LE L +EK
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 253 ETELKDLRKQ----SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK---------- 298
E ++K+L ++ EII +L E + + E + A D Q EDKV SL
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQV 1033
Query: 299 TDIEESKYRQRHLKVELKSFLEVLDGKI 326
D+E S +++ ++++L+ L+G +
Sbjct: 1034 DDLEGSLEQEKKVRMDLERAKRKLEGDL 1061
Score = 43.1 bits (100), Expect = 4e-04
Identities = 59/280 (21%), Positives = 113/280 (40%), Gaps = 55/280 (19%)
Query: 68 TKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNH 127
+K + + QW E+ K A++ Q+ +EA + K +E + +
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS-LEKTKHR 1422
Query: 128 SQASSVNGTDDEKASHAGPANTHLKSEN-DKL----KIALTQSAANVKKWEIELQTLRES 182
Q + D + S+A A K N DK+ K +S + ++ + E ++L
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1482
Query: 183 NARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE---------------------- 220
+L A +ES +E +KR+ ++E L ++ E
Sbjct: 1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 221 ---LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVS 277
LEE + + E+ K + + +++AE+ K E KD
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE-KD------------------- 1582
Query: 278 EKLEAAERDNQNLEDKVRSLKTDIE-ESKYRQRHLKVELK 316
E++E A+R++Q + D SL+T ++ E++ R L+V+ K
Sbjct: 1583 EEMEQAKRNHQRVVD---SLQTSLDAETRSRNEVLRVKKK 1619
Score = 42.7 bits (99), Expect = 5e-04
Identities = 61/255 (23%), Positives = 109/255 (42%), Gaps = 30/255 (11%)
Query: 98 KFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQAS---------SVNGTDDE---KASHAG 145
K AEK +E+ E AK + + ++TS + S + G +E + SHA
Sbjct: 1577 KLAEKDEEM-EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Query: 146 ----PANTHLKSENDKLK---IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE 198
A +KS LK I L + + + + N L L+E A VE
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1695
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKN----TQLKRRIEELEAELREKET 254
Q +R + E ++ L Q + + +K+K TQL+ +EE E R E
Sbjct: 1696 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 255 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 314
+ K + ++ + + + + S L ER +N+E ++ L+ ++E++ Q LK
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSAHL---ERMKKNMEQTIKDLQHRLDEAE--QIALKGG 1810
Query: 315 LKSFLEVLDGKIDDL 329
K L+ L+ ++ +L
Sbjct: 1811 KKQ-LQKLEARVREL 1824
Score = 41.2 bits (95), Expect = 0.001
Identities = 57/274 (20%), Positives = 106/274 (38%), Gaps = 62/274 (22%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE---TSSNHSQASSVNGTDDEKASHAGPAN 148
S +L + + Q VK+ K+ K+K++ K+E +SN Q + EK S
Sbjct: 1201 SVAELGEQIDNLQRVKQ--KLEKEKSEFKLELDDVTSNMEQIIKAKA-NLEKVSRT---- 1253
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQW-------- 200
L+ + ++ ++ L ++ ++ + + L+ N L L+E A + Q
Sbjct: 1254 --LEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYT 1311
Query: 201 ------KRQFS--------------ICRDENDRLRNKIDELEEQCSEINREKEK------ 234
KRQ R + D LR + +E E +E+ R K
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 235 ------NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQ 288
T +R EELE ++ L+D + E V+ K + E+
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE----------AVEAVNAKCSSLEKTKH 1421
Query: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 322
L++++ L D+E S L + ++F ++L
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1455
Score = 32.3 bits (72), Expect = 0.63
Identities = 47/246 (19%), Positives = 97/246 (39%), Gaps = 22/246 (8%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKAS--HAGPANTH 150
E+ + + + +E+ E + A T +IE + D E+A+ H A
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ-------WKRQ 203
K D + L + N+++ + Q L + + L + +++EQ ++
Sbjct: 1195 RKKHADSVA-ELGEQIDNLQRVK---QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKV 1250
Query: 204 FSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQS 263
D+ + R K++E + ++ ++ K L+ EL +L EKE + L +
Sbjct: 1251 SRTLEDQANEYRVKLEEAQRSLNDFTTQRAK---LQTENGELARQLEEKEALISQLTRGK 1307
Query: 264 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD---IEESKYRQRHLKVELKSFLE 320
Q M E + +LE + L ++S + D + E + K EL+ L
Sbjct: 1308 LSYTQQM---EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1364
Query: 321 VLDGKI 326
+ ++
Sbjct: 1365 KANSEV 1370
Score = 30.0 bits (66), Expect = 3.1
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 6/113 (5%)
Query: 220 ELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEK 279
E+ E R KE + + R +ELE ++ E DL+ Q + +++ E E+
Sbjct: 850 EMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE---ER 906
Query: 280 LEAAERDNQNLEDKVRSLKTDIEESKYRQRHL---KVELKSFLEVLDGKIDDL 329
+ ++ LE KV+ + +E+ + L K +L+ L IDDL
Sbjct: 907 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDL 959
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 59.3 bits (142), Expect = 5e-09
Identities = 66/263 (25%), Positives = 115/263 (43%), Gaps = 28/263 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
++E ++ E+ + E IAK T+EK H Q +++K + A T
Sbjct: 974 ATENKVKNLTEEMAGLDET--IAK-LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ + D L+ +L Q KK ++L+ + QES E K+Q
Sbjct: 1031 LEQQVDDLEGSLEQE----KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL------ 1080
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEII 266
N++L+ K E+ +I E+ QL+++I+EL+A + E E E++ R K +
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 267 PQLMSECEYVSEKLEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK--- 316
L E E +SE+LE A N+ E + + ++ D+EES + L+
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH 1200
Query: 317 -SFLEVLDGKIDDLHDFRRGLSK 338
+ L +ID L ++ L K
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLEK 1223
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/230 (20%), Positives = 110/230 (47%), Gaps = 10/230 (4%)
Query: 96 LTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASS-----VNGTDDEKASHAGPA--- 147
L K F +V K ++TQ ++E S S++ S V +E H
Sbjct: 1446 LDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N +L+ E L + + ++ + E + L + L T+L+E+ AS+E + +
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 208 RDENDRLRNKID-ELEEQCSEINREKEKNTQLKRRIEE-LEAELREKETELKDLRKQSEI 265
+ E ++++++ID ++ E+ E+++ K + ++ ++ L+AE+R + L+ +K
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
+ ++ + + + + A R+ +N + ++ + ++++ Q LK +L
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQL 1675
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/263 (21%), Positives = 123/263 (46%), Gaps = 40/263 (15%)
Query: 95 QLTKFAEKF-QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
QL++ + F Q+++E + +++T+ K ++ H+ S+ + D + + K+
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEETKAK--STLAHALQSARHDCDLLREQYE--EEQEAKA 1359
Query: 154 ENDKLKIALTQSAANVKKWEIELQT--------LRESNARLTTALQESAASVEQWKRQFS 205
E L+ ++++ + V +W + +T L E+ +L LQ++ VE + +
Sbjct: 1360 E---LQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCA 1416
Query: 206 ICRDENDRLRNKIDELEEQCSEINR------EKEKN-----TQLKRRIEELEAELREKET 254
RL+N++++L N +K++N + K++ EE +AEL E
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAEL---EA 1473
Query: 255 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKT----------DIEES 304
K+ R S + ++ + E + LE +R+N+NL+ ++ L ++E+
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533
Query: 305 KYRQRHLKVELKSFLEVLDGKID 327
K + H K EL++ LE + ++
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLE 1556
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/188 (20%), Positives = 88/188 (46%), Gaps = 20/188 (10%)
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 208
+ LK + D L++ L + E +++ L E A L E+ A + + K+
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA----GLDETIAKLTKEKKALQEAH 1007
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
+ +D+L+ + ++N + T+L++++++LE L +++ DL + +
Sbjct: 1008 QQT------LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR---K 1058
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYR-----QRHLKVELKSFLEVLD 323
L + + E E D Q L +K++ K + E S + ++ L ++L+ ++ L
Sbjct: 1059 LEGDLKLAQESTMDTENDKQQLNEKLK--KKEFEMSNLQGKIEDEQALAIQLQKKIKELQ 1116
Query: 324 GKIDDLHD 331
+I++L +
Sbjct: 1117 ARIEELEE 1124
Score = 45.1 bits (105), Expect = 9e-05
Identities = 47/208 (22%), Positives = 94/208 (45%), Gaps = 33/208 (15%)
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
NT L + KL+ ++Q + E +Q R + + A+ ++A E+ K++
Sbjct: 1724 NTSLINTKKKLETDISQIQGEM---EDIVQEARNAEEKAKKAITDAAMMAEELKKE---- 1776
Query: 208 RDENDRLRNKIDELEEQCSEINREKEKNTQL-----KRRIEELEAELREKETELKDLRKQ 262
+D + L +E+ ++ ++ QL K++I++LEA +RE E+E++ +K
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKH 1836
Query: 263 S-EIIPQLMSECEYVSEKLEAAERDNQN----------LEDKVRSLKTDIEE-------- 303
+ E + L V E E D +N L+ KV++ K EE
Sbjct: 1837 NVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVN 1896
Query: 304 -SKYRQ-RHLKVELKSFLEVLDGKIDDL 329
+K+R+ +H E K ++ + +++ L
Sbjct: 1897 LAKFRKLQHELEEAKERADIAESQVNKL 1924
Score = 43.5 bits (101), Expect = 3e-04
Identities = 47/217 (21%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
+E+++ E+F++ KE ++AK + + K + + +D + A+
Sbjct: 849 TEKEMANMKEEFEKTKE--ELAKTEAKRK---ELEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 152 KSEN--DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRD 209
+E D+L Q A +K+ + E NA LT KR+ D
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK-----------KRKLE---D 949
Query: 210 ENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL-KDLRKQSEIIPQ 268
E L+ ID+LE +++ +EK + + E A L E +L K+ + E Q
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
+ + + +K+ + LE +V L+ +E+ K
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEK 1046
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/190 (22%), Positives = 78/190 (41%), Gaps = 20/190 (10%)
Query: 140 KASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQ 199
K++ ++K E +K K L ++ A K+ E ++ TL + L +Q A ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 200 WKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDL 259
+ + +L KI E+ E+ + E+E N +L + +LE E E + ++ DL
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAED---EEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 260 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFL 319
L E++ E+KV++L ++ L E K+
Sbjct: 962 ELT-----------------LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 320 EVLDGKIDDL 329
E +DDL
Sbjct: 1005 EAHQQTLDDL 1014
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/166 (21%), Positives = 78/166 (46%), Gaps = 20/166 (12%)
Query: 180 RESNARLTTALQESAASVEQWKRQF---SICRDEN-----DRLRNKIDELEEQCSEINRE 231
+E+ A L + ++ + V QW+ ++ +I R E +L ++ + EE +N +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 232 ----KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC----EYVSEKLEAA 283
++ +L+ +E+L ++ L K+ ++++E E +LEA+
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 284 ERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
++++++L ++ +K EES LK E K+ L +I DL
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKN----LQQEISDL 1516
Score = 40.0 bits (92), Expect = 0.003
Identities = 47/234 (20%), Positives = 94/234 (40%), Gaps = 16/234 (6%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKAS--HAGPANT 149
+E+Q + + + +E+ E + A T +IE + D E+++ H A
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195
Query: 150 HLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVE---QWKRQFS- 205
K D ++ + + + Q L + + L + + A+++E + K F
Sbjct: 1196 LRKKHAD----SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK 1251
Query: 206 ICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEI 265
+CR D+L + EEQ IN + +L E +L EK+ + L + +
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQA 1311
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD---IEESKYRQRHLKVELK 316
Q + E + +LE + L ++S + D + E ++ K EL+
Sbjct: 1312 FTQ---QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQ 1362
Score = 39.3 bits (90), Expect = 0.005
Identities = 60/295 (20%), Positives = 122/295 (41%), Gaps = 36/295 (12%)
Query: 76 QWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
Q + + NT+ EQQ+ ++ K+ + ++ + K+E +Q S+++
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC-MDLERAKRKLEGDLKLAQESTMDT 1073
Query: 136 TDDE-------KASHAGPANTHLKSENDK-----LKIALTQSAANVKKWEIELQTLRESN 183
+D+ K +N K E+++ L+ + + A +++ E E++ R S
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 184 AR-------LTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNT 236
A+ L+ L+E + +E+ S + N + + ++ E + E
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 237 Q-LKRRIEELEAELREKETELKDLRKQSEI--------IPQLMSECEYVSEKLEAAERDN 287
L+++ + AEL E+ L+ ++++ E I L S E VS+ E+
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMC 1253
Query: 288 QNLEDKVRSLKTDIEESK-------YRQRHLKVELKSFLEVLDGKIDDLHDFRRG 335
+ LED++ +KT EE + ++ L E F LD K + RG
Sbjct: 1254 RTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG 1308
Score = 38.5 bits (88), Expect = 0.009
Identities = 55/241 (22%), Positives = 101/241 (41%), Gaps = 39/241 (16%)
Query: 93 EQQLTKFAEKFQEVK-EAAKIAKDKTQEKIETSSNHSQA-SSVNGTDDEKASHAGPANTH 150
E ++ + + +VK E + +K +E + NH + S+ T D +
Sbjct: 1559 EGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAE---------- 1608
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
++S ND L+I KK E +L E +L A +++A ++ + I +D
Sbjct: 1609 IRSRNDALRIK--------KKMEGDLN---EMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 211 NDRLRNKI---DELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP 267
L + I D+L+EQ + + R + ++ +EEL A L E RK +E
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVER---RANLMQAEVEELRASLERTERG----RKMAE--- 1707
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKID 327
E SE+++ N +L + + L+TDI + + + E ++ E I
Sbjct: 1708 ---QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAIT 1764
Query: 328 D 328
D
Sbjct: 1765 D 1765
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 58.5 bits (140), Expect = 8e-09
Identities = 71/298 (23%), Positives = 128/298 (42%), Gaps = 53/298 (17%)
Query: 79 DSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQE------KIETSSNHSQASS 132
D R + LG S Q++ +K +E +E K K++E K+E H +AS
Sbjct: 252 DERQMHIEQLGLQS-QKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEH-KASR 309
Query: 133 VNGTDDEKASHAGPANTHLKSENDKLKIALTQ-------SAANVKKWEIELQTLRESNAR 185
+ +E + +H + KL + LTQ + N++K E ELQ LR+ A+
Sbjct: 310 FSQEHEEMNAKLANQESHNRQLRLKL-VGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
Query: 186 LTTALQESAASVEQWKRQF--------------SICRD----------ENDRLRNKIDEL 221
A VE +++ S CR+ + LR ++++L
Sbjct: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKL 428
Query: 222 EEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE 281
+++ SE+ + +E ++ K +L L +++ KDL + E++ + E E +LE
Sbjct: 429 QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLE 488
Query: 282 AAERDNQNLEDKVRSLKTD----IEESKYRQRHLKVE------LKSFLEVLDGKIDDL 329
AE +L+D + LK+ ++E K +K E L +V GK+ D+
Sbjct: 489 KAE---LSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDV 543
Score = 49.3 bits (116), Expect = 5e-06
Identities = 59/250 (23%), Positives = 111/250 (44%), Gaps = 38/250 (15%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E+Q + +++ A K + +T ++E + H +N +DD L+
Sbjct: 156 EKQKETYRRMLEQLLLAEKCHR-RTVYELE-NEKHKHTDYMNKSDD--------FTNLLE 205
Query: 153 SENDKLKIALTQSAANVKKWEIE----LQTLRESNARLTT----ALQESAASVEQWKRQF 204
E ++LK L Q A + E E L LR+ +L + + E +EQ Q
Sbjct: 206 QERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQS 265
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLK-----------RRIEELEAELREKE 253
+D +LR + ++L+ S+ +++K +L+ + EE+ A+L +E
Sbjct: 266 QKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQE 325
Query: 254 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKV-------RSLKTDIEESKY 306
+ + LR + + Q + E E ++ L+ AE + Q L DK+ SL ++E
Sbjct: 326 SHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVE--NL 383
Query: 307 RQRHLKVELK 316
R+R L++E K
Sbjct: 384 RKRVLEMEGK 393
Score = 38.5 bits (88), Expect = 0.009
Identities = 58/280 (20%), Positives = 115/280 (41%), Gaps = 48/280 (17%)
Query: 84 TVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASH 143
T L E+ LTK ++ ++ K + +E +E S + + + ++ DD
Sbjct: 450 TQLHLNLEKEKNLTK------DLLNELEVVKSRVKE-LECSESRLEKAELSLKDDL---- 498
Query: 144 AGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRES-NARLTTALQESAASVEQWKR 202
T LKS L +K+ E ++ L ++ + + +E+ K+
Sbjct: 499 -----TKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
Query: 203 QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL-------KRR---IEELEAELRE- 251
+ + +++ N E +E ++ E+EK+++L K+R IEE+E E+
Sbjct: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
Query: 252 -----------KETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS---- 296
++ ++K+L + E + + + + E V L E + LE K R+
Sbjct: 614 RSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDK 673
Query: 297 ---LKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFR 333
L +EE K++ K K EV+ + + H FR
Sbjct: 674 ANFLSQQLEEIKHQIAKNKAIEKG--EVVSQEAELRHRFR 711
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 57.8 bits (138), Expect = 1e-08
Identities = 60/247 (24%), Positives = 105/247 (42%), Gaps = 10/247 (4%)
Query: 81 RANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEK 140
R N F + LTK + + +KEA ++ D+ +E I + Q S
Sbjct: 1332 RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN 1391
Query: 141 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQW 200
T + SE ++ K + + + EIE+ L + ++ A +
Sbjct: 1392 MKEKDNETTKIVSEMEQFK----PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 201 KRQFSICRDENDRLRNKIDELEEQCSEINRE-KEKNTQLKRR---IEELEAELREKETEL 256
+R + + E+D+L+ I E+ + E E K + LK + I EL L EKETE+
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 257 KDLRKQSEII-PQLMSECEYVSEKLEAAE-RDNQNLEDKVRSLKTDIEESKYRQRHLKVE 314
++KQ E I +L ++ + + EK E + +++KV LK E K + L+
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567
Query: 315 LKSFLEV 321
LE+
Sbjct: 1568 ESKMLEL 1574
Score = 48.9 bits (115), Expect = 7e-06
Identities = 46/217 (21%), Positives = 101/217 (46%), Gaps = 22/217 (10%)
Query: 114 KDKTQEKI-------ETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSA 166
KD+ Q+K+ + + ++Q + + D+E + ++ +N+ L Q
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE-----LQQML 1059
Query: 167 ANVKKWEIELQTLRESNARLTTALQESAASV-EQWKRQFSICRDENDRLRNKIDELEEQC 225
+V + +L+T + N +T QE + ++ K+Q I E + K EL C
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 226 SEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECE--------YVS 277
+ +EK + ++++E + +L + E+ +++K+ I L +E + +
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 278 EKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 314
E+LE A++ N+N E+ V+S+ + + K Q+ + E
Sbjct: 1180 ERLELAQKLNENYEE-VKSITKERKVLKELQKSFETE 1215
Score = 48.1 bits (113), Expect = 1e-05
Identities = 55/259 (21%), Positives = 108/259 (41%), Gaps = 42/259 (16%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKD-----------KTQEKIETSSNHSQASSVNGTDDEKAS 142
Q + K E+ + V+EA +I +D K +E E + ++VN T ++
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 143 HAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR 202
HLK + + K+ L+ + N RLT L E+ + +
Sbjct: 1646 IE-----HLKEQFETQKL--------------NLENIETENIRLTQILHENLEEMRSVTK 1686
Query: 203 QFSICRDENDRLRNKIDELEEQCSE-INREKEKNTQLK----------RRIEELEAELRE 251
+ R + L+ + D+L+E E I R+ EK +LK I++L + E
Sbjct: 1687 ERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 252 KETELKDLRKQSE-IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRH 310
K E+ +++K E L ++ + E+L A + ++ + L+ + E + +
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN 1806
Query: 311 LKVELKSFLEVLDGKIDDL 329
++ +L++ L KI +L
Sbjct: 1807 MQKDLENSNAKLQEKIQEL 1825
Score = 48.1 bits (113), Expect = 1e-05
Identities = 51/256 (19%), Positives = 113/256 (44%), Gaps = 41/256 (16%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+ +TK + + V+E K+ +D+ +E + + D EK + HLK
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITR---------DLEKQEELKIVHMHLKE 1732
Query: 154 EN---DKLKIALTQSAANVKKWEIELQ----TLRESNARLTTALQESAASVEQWKRQFS- 205
DKL+ +++ + + +L+ L+ + ++ L+ + +++ +
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
Query: 206 ---ICRDENDRL-------RNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETE 255
I ++ D+L N +L+E+ E+ + + LK+ + E + ++ E E
Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852
Query: 256 LKDLRKQSEIIPQLMSECEYVSEKLE---------AAERDN-QNLEDKVR----SLKTDI 301
K ++ QS + +L E +++KL ERDN + +E+ ++ LK +
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 302 EESKYRQRHLKVELKS 317
+E+K R ++ ELK+
Sbjct: 1913 QETKARDLEIQQELKT 1928
Score = 46.2 bits (108), Expect = 4e-05
Identities = 45/230 (19%), Positives = 97/230 (42%), Gaps = 17/230 (7%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+Q K QE E ++ + EK + ++ + + + E+ G
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG-------D 1092
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
E K + + Q + K E EL + A + L+E + +++ ++Q ++E
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 273
++ KI+E+E +E+ ++ ++ EL +L E E+K + K+ +++ +L
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 274 EYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
E ERD +L +R ++ ++K + + LK E +D
Sbjct: 1213 E--------TERD--HLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Score = 45.1 bits (105), Expect = 9e-05
Identities = 56/242 (23%), Positives = 103/242 (42%), Gaps = 30/242 (12%)
Query: 105 EVKEAAKIAKDKTQE-KIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 163
EV+ K +DK++E I TS S V H L E K K L
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEV--------VHKESRVQGLLEEIGKTKDDLA 806
Query: 164 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEE 223
+ +N K + E Q + + +++++ + +EN+R+ +I L +
Sbjct: 807 TTQSNYKSTDQEFQNFKTLHM--------------DFEQKYKMVLEENERMNQEIVNLSK 852
Query: 224 QCSEINREKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVS-EKLE 281
+ + + T+L + +EL+ + RE + L ++ + E + S + V EK
Sbjct: 853 EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 282 AAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE---LKSFL-EVLDGKIDDLHDFRRGLS 337
E+ Q LE+ V++L + ++ K Q L++E LKS + + ++ ID R L
Sbjct: 913 ITEKLQQTLEE-VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 338 KL 339
L
Sbjct: 972 SL 973
Score = 44.3 bits (103), Expect = 2e-04
Identities = 38/159 (23%), Positives = 77/159 (48%), Gaps = 16/159 (10%)
Query: 164 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEE 223
+SA K+WE +L++L+E N +L Q S+ + +D NK +
Sbjct: 2320 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD------NKNPHVTS 2373
Query: 224 QCSEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEIIPQLMSECEYVSEK 279
+ +++ EK + +L+ + E + KE+++ K+L ++II +L ++ ++
Sbjct: 2374 RATQLTTEKIR--ELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC 2431
Query: 280 LEAAERDNQNLEDKV----RSLKTDIEESKYRQRHLKVE 314
LE + Q L+DKV + K +IE+ K + + +E
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLE 2470
Score = 42.0 bits (97), Expect = 8e-04
Identities = 38/168 (22%), Positives = 83/168 (49%), Gaps = 17/168 (10%)
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
EN+++ + + +K++ L L+ + T LQE V++ +E ++
Sbjct: 839 ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL-------NEMEQ 891
Query: 214 LRNKIDELEEQCSEINREKEKNTQ-LKRRIEELEAELREKETELKDLRKQSEI-IPQLMS 271
L+ +++ + + REK T+ L++ +EE++ +EK+ +LK L++ +I QL S
Sbjct: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD-DLKQLQESLQIERDQLKS 950
Query: 272 EC-EYVSEKLEAAERDNQNLE------DKVRSLKTDIEESKYRQRHLK 312
+ + V+ ++ E+ LE + + +LK+ I E R H++
Sbjct: 951 DIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHME 998
Score = 42.0 bits (97), Expect = 8e-04
Identities = 51/262 (19%), Positives = 108/262 (41%), Gaps = 39/262 (14%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
++ + + K E +E K+A +E+ ET + + EK + L+
Sbjct: 1462 KENIKEIVAKHLETEEELKVAHCCLKEQEET------INELRVNLSEKETEISTIQKQLE 1515
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQ-------FS 205
+ NDKL+ + + +++ N + + +QE ++Q+K
Sbjct: 1516 AINDKLQNKIQEIYEKEEQF----------NIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 206 ICRDENDRLRNKIDELEEQCSEINREKE-----------KNTQLKRRIEELEAELREKET 254
+ L N++ E +E+ + +EKE + QLK +E+ A+++E +
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 255 ELKDLRKQSEI--IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK 312
+ K + + + M E E++ E+ E + + +N+E + L + E+ R +
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVT 1685
Query: 313 VE---LKSFLEVLDGKIDDLHD 331
E L+S E L + D L +
Sbjct: 1686 KERDDLRSVEETLKVERDQLKE 1707
Score = 40.8 bits (94), Expect = 0.002
Identities = 46/252 (18%), Positives = 108/252 (42%), Gaps = 16/252 (6%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+ + K + + V+E K+ +D+ +E ++ ++A + + K + + K
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQ----ETKARDLEIQQELKTARM--LSKEHKE 1938
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
DKL+ +++ + + +L ++ + LQ+ + + K ++ + +
Sbjct: 1939 TVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE 1998
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 273
+ + E Q + + N QL +++ E E+R E +LR+ E + M
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK--MERD 2056
Query: 274 EYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK---SFLEVLDGKIDDLH 330
++++ E RD QN +V+ K + + Q+HL L+ S ++ L + ++
Sbjct: 2057 QFIATLREMIARDRQN--HQVKPEKRLLSDG---QQHLTESLREKCSRIKELLKRYSEMD 2111
Query: 331 DFRRGLSKLGTD 342
D L++L D
Sbjct: 2112 DHYECLNRLSLD 2123
Score = 38.5 bits (88), Expect = 0.009
Identities = 66/280 (23%), Positives = 123/280 (43%), Gaps = 45/280 (16%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASS-----VNGTDDEKASHAGPA 147
E +L++ ++ EV+E K + QEK + N + S +N ++ K
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171
Query: 148 NT--HLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFS 205
T H+++E +L L ++ VK E + L+E LQ+S + R +
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKE--------LQKSFETERDHLRGY- 1222
Query: 206 ICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEA------ELREKETELKD- 258
I E L+ K +EL+ + +E +L+R + E A +L + T+L++
Sbjct: 1223 IREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 259 ---LRKQSEIIP---------QLMSECEYVSEKLEAAERDNQNL---EDKVRSLKTDIEE 303
L ++ E++P + M+E E ++E ++ +D+ L E + L +E
Sbjct: 1282 IPVLHEEQELLPNVKEVSETQETMNELELLTE--QSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 304 SKYRQRHLKVE---LKSFLEVLDGKIDDLHD-FRRGLSKL 339
S+ + L E LK+ E L+ K D L + R L+K+
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379
Score = 34.7 bits (78), Expect = 0.13
Identities = 41/183 (22%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 147 ANTHLKSENDKLKIALTQSAANVKK-----WEIELQTLRESNARLTTALQ---------- 191
A T+ + END I L QS KK E ELQ+ +LT+ +
Sbjct: 659 ATTYKQMEND---IQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCN 715
Query: 192 -ESAASVEQWKRQFSICRDENDRLRNKI---DELEEQCSEINREKEKNTQLKRRIEELEA 247
E + +++ + +EN+ LR ++ EL+ SE+ R ++ +++ + EEL
Sbjct: 716 LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRK---EIQDKSEELHI 772
Query: 248 ELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKT---DIEES 304
EK+ ++ + + L+ E + L + + ++ + + ++ KT D E+
Sbjct: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ- 831
Query: 305 KYR 307
KY+
Sbjct: 832 KYK 834
Score = 33.9 bits (76), Expect = 0.22
Identities = 52/243 (21%), Positives = 105/243 (43%), Gaps = 23/243 (9%)
Query: 90 FSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANT 149
F + ++ TK ++ Q + E + + ++ ++ SS EK
Sbjct: 537 FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQE 596
Query: 150 HLKSEN-DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICR 208
++ S+ + +K+ L+ S +++ + QTL ++ T AL KR+ + R
Sbjct: 597 YIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAE---TVALDA--------KRESAFLR 645
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 268
EN L+ K+ EL + ++ E + QL + +LEA+ + + K+L+ I +
Sbjct: 646 SENLELKEKMKEL----ATTYKQMENDIQLYQ--SQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE--LKSFLEVLDGKI 326
L S + K+ N LE K+ L+ ++ + L+ E L S L+ L ++
Sbjct: 700 LTS---LIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756
Query: 327 DDL 329
+ L
Sbjct: 757 ERL 759
Score = 30.4 bits (67), Expect = 2.4
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 29/156 (18%)
Query: 168 NVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSE 227
N + E EL +LR L ++ E+ + + + +N +DE E E
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL--------KEKNDLDEFE--ALE 541
Query: 228 INREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN 287
+K++ QL I L+ ++ E +DL +L S+ E + EK
Sbjct: 542 RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN------ELSSKVELLREK-------- 587
Query: 288 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
ED+++ L+ I+ K ++K++L LE ++
Sbjct: 588 ---EDQIKKLQEYIDSQKL--ENIKMDLSYSLESIE 618
Score = 29.3 bits (64), Expect = 5.4
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 10/104 (9%)
Query: 234 KNTQLKRRIEELEAELREKETELKDLRKQSEII-----PQLMSE---CEYVSEKLEAAER 285
KNT + EA L+ E+ DL+KQ E + Q M + + + EK +
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKV 389
Query: 286 DNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
N+ +E+ R L T S Q+ LK + K + GKI+ +
Sbjct: 390 QNEKIENLTRMLVT--SSSLTLQQELKAKRKRRVTWCLGKINKM 431
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 57.4 bits (137), Expect = 2e-08
Identities = 54/238 (22%), Positives = 116/238 (48%), Gaps = 37/238 (15%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
Q++ + QE++++ ++K Q +T + H + E + N L+
Sbjct: 1226 QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT----ETMNVVMETNKMLRE 1281
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
E ++L+ L Q A V+K E+++ L+E+NA L+ E + ++ K+ + ++ R
Sbjct: 1282 EKERLEQDLQQMQAKVRKLELDILPLQEANAELS----EKSGMLQAEKK---LLEEDVKR 1334
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 273
+ + L ++++K+ +T+ R++ L EKE K +++ +E I +L +E
Sbjct: 1335 WKARNQHL------VSQQKDPDTEEYRKL------LSEKEVHTKRIQQLTEEIGRLKAEI 1382
Query: 274 EYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 331
+ A+ +NQNL ++SLK D+ + ++ E ++ + LD KI D+ +
Sbjct: 1383 ----ARSNASLTNNQNL---IQSLKEDLNK-------VRTEKETIQKDLDAKIIDIQE 1426
Score = 56.6 bits (135), Expect = 3e-08
Identities = 65/256 (25%), Positives = 118/256 (46%), Gaps = 37/256 (14%)
Query: 91 SSEQQLTKF-AEKFQEVK------EAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASH 143
S + +L KF A++ E+ E K+ ++ +IE +HSQ VN T + ++
Sbjct: 20 SVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLR 79
Query: 144 AG--PANTHLKS---ENDKLKIALTQSAA-------NVKKWEIELQTLRESNARLTTALQ 191
N LK+ +N +L+IA ++ A ++ E E + L +N RL+ L+
Sbjct: 80 LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE 139
Query: 192 ESAASVEQWKRQFSICRDENDRLRNKIDELEE-----QCSEINREKEK----------NT 236
V++ + L+ K+DEL+ + E E+EK NT
Sbjct: 140 YLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNT 199
Query: 237 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 296
+LK + +EL A REK E+ +L+ E + +S E E++ + N++L+ V
Sbjct: 200 ELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE---EQMNGLKTSNEHLQKHVED 256
Query: 297 LKTDIEESKYRQRHLK 312
L T ++E+K +Q ++
Sbjct: 257 LLTKLKEAKEQQASME 272
Score = 45.4 bits (106), Expect = 7e-05
Identities = 41/168 (24%), Positives = 76/168 (45%), Gaps = 24/168 (14%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
LK ++K K+ Q ++K L S RL +E + R E
Sbjct: 39 LKGRHEKFKVESEQQYFEIEK------RLSHSQERLVNETRECQS-----------LRLE 81
Query: 211 NDRLRNKIDELEEQCSEINREKEKN----TQLKRRIEELEAELREKETELKDLRKQSEII 266
++L N++ L E+ E+ +++N +Q R EELEAE R+ ++ + S+ +
Sbjct: 82 LEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL---IRTNERLSQEL 138
Query: 267 PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 314
L + + ++EKL+ + L+ K+ L+ KYR++ L+ E
Sbjct: 139 EYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
Score = 45.4 bits (106), Expect = 7e-05
Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 25/204 (12%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTA--------------LQESAAS 196
L E +LK + +S A++ + +Q+L+E ++ T +QE +
Sbjct: 1371 LTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKT 1430
Query: 197 VEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL 256
+ Q K+ + + + L+ + D++ E ++ + + ++ + ++EL+ L + ET+
Sbjct: 1431 ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS 1490
Query: 257 KDLRKQSEIIPQLMSECEYVSEKLE--------AAERDNQNLEDKV---RSLKTDIEESK 305
K L Q E + + +SE E + L+ R Q+L+D+ L+ I E +
Sbjct: 1491 KSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550
Query: 306 YRQRHLKVELKSFLEVLDGKIDDL 329
+ R V KS + L G D L
Sbjct: 1551 EKTRKAIVAAKSKIAHLAGVKDQL 1574
Score = 43.5 bits (101), Expect = 3e-04
Identities = 54/227 (23%), Positives = 100/227 (44%), Gaps = 26/227 (11%)
Query: 110 AKIAKDKTQEKIETSSNHSQASSVNGT-DDEKASHAGPANTHLKSENDKLKIALTQSAA- 167
AK A + QE E N+ + + N +E+ T L+S+N K+ L ++
Sbjct: 668 AKAALKQLQEIFE---NYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
Query: 168 ------NVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDEL 221
NV+ + E+ +L E N +LT Q+ + + R N+ K+
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDL---RGANE----KLAVA 777
Query: 222 EEQCSEINREKE----KNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC-EYV 276
E + + +EKE +L ++ E L AE R + L +L+ I+ + +E + +
Sbjct: 778 EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 277 SEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 323
S ++E E + +L+ K L+ ++E+ R+L V+L LD
Sbjct: 838 SSQIEKLEHEISHLKKK---LENEVEQRHTLTRNLDVQLLDTKRQLD 881
Score = 37.4 bits (85), Expect = 0.020
Identities = 61/334 (18%), Positives = 133/334 (39%), Gaps = 38/334 (11%)
Query: 30 QAVTVSYFYDVTRNSYRII--SVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFG 87
Q +S D Y ++ +V+G + I S N T T+QK Q ++ + G
Sbjct: 710 QNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRG 769
Query: 88 LG------------FSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
E+++ K +E + + +A+ + Q + T+ Q
Sbjct: 770 ANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERS 829
Query: 136 TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAA 195
+ K L S+ +KL+ ++ KK E E++ L L ++
Sbjct: 830 ETETKQ--------RLSSQIEKLEHEISHLK---KKLENEVEQRHTLTRNLDVQLLDTKR 878
Query: 196 SVE-------QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL--KRRIEELE 246
++ K + E L+ + +E Q + + ++ Q K +++L
Sbjct: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
Query: 247 AELREKETELKDLRKQSEIIPQLMSECEYVSEKL-EAAERDNQNLEDKVRSLKTDIEESK 305
++LR+ E ++ DL+++ + + + + + L E+ ++ Q E+ ++++ ++ES
Sbjct: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 306 YRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
Q L+ K +EV K + D RR + +
Sbjct: 999 EFQTQLE---KKLMEVEKEKQELQDDKRRAIESM 1029
Score = 37.0 bits (84), Expect = 0.026
Identities = 45/217 (20%), Positives = 94/217 (43%), Gaps = 14/217 (6%)
Query: 116 KTQEKIETSSNHSQASSVNG---TDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
+ ++++E +++ A+ G +++E A+ + A K +K+ +A +
Sbjct: 348 RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID----ELEEQCSEI 228
++ L+ L N R+ L E VE R+E +R + + +LE+ EI
Sbjct: 408 QLLLEKLE--NKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
Query: 229 NREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC--EYVSEKLEAAERD 286
R +E + ++ LE + R E ++KDL +Q ++ + E +V E + D
Sbjct: 466 QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
Query: 287 NQNLEDKVRS---LKTDIEESKYRQRHLKVELKSFLE 320
+ + + +IEE + + + L V L+ E
Sbjct: 526 ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE 562
Score = 36.2 bits (82), Expect = 0.044
Identities = 47/220 (21%), Positives = 92/220 (41%), Gaps = 13/220 (5%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTD----DEKASHAGPANTHLKSENDK 157
+F KE + K ++ I T+ SQ D +EK + L+ + D+
Sbjct: 112 QFTRTKEELEAEK---RDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168
Query: 158 LKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQF-SICRDENDRLRN 216
L+ + K+ E E + L N L T L+ + R+ + + L N
Sbjct: 169 LQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLEN 228
Query: 217 KIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQ--SEIIPQLMSECE 274
K +E+ ++N K N L++ +E+L +L+E + + + ++ +E+ +
Sbjct: 229 KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNL 288
Query: 275 YVSEKLEAAERDNQ---NLEDKVRSLKTDIEESKYRQRHL 311
Y S ++ + N+ +E+ + LK E +K Q HL
Sbjct: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
Score = 34.7 bits (78), Expect = 0.13
Identities = 33/140 (23%), Positives = 64/140 (45%), Gaps = 13/140 (9%)
Query: 139 EKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNA----RLTTALQESA 194
E A ++ L+ +N +++I + + ++ +EL+ R ++ +++A S+
Sbjct: 470 EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
Query: 195 ASVEQWK----RQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELR 250
+ V R + +N RL + EL E RE+E+ +I EL+ +L
Sbjct: 530 SEVISQHLVSYRNIEELQQQNQRLLVALRELGE-----TREREEQETTSSKITELQLKLE 584
Query: 251 EKETELKDLRKQSEIIPQLM 270
TEL+ LRK + QL+
Sbjct: 585 SALTELEQLRKSRQHQMQLV 604
Score = 30.0 bits (66), Expect = 3.1
Identities = 54/281 (19%), Positives = 120/281 (42%), Gaps = 57/281 (20%)
Query: 81 RANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEK 140
R N L S+E Q T+ +K EV++ + +D + IE S Q S + T
Sbjct: 987 RKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIE--SMEQQLSELKKT---- 1039
Query: 141 ASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQW 200
L S ++++ AL +++ + E Q R+ + A++ ++
Sbjct: 1040 ----------LSSVQNEVQEALQRASTALSN---EQQARRDCQEQAKIAVEAQ----NKY 1082
Query: 201 KRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELK--- 257
+R+ + + + L+ +++ + S +E + + ++ E +A E+E LK
Sbjct: 1083 ERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
Query: 258 --------DLRKQSEIIPQLMSECEYVSEKLEAAERD------NQNLEDKVRSLKTDIEE 303
DL KQ+ + L + E +S+K+ A+ ++ N +L ++ +S + +E
Sbjct: 1143 SKCVCRCEDLEKQNRL---LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 304 SKYRQRHLKVELKSF-------------LEVLDGKIDDLHD 331
++ +R ++ F +E+L+ ++ +L D
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 57.4 bits (137), Expect = 2e-08
Identities = 61/271 (22%), Positives = 108/271 (39%), Gaps = 56/271 (20%)
Query: 93 EQQLTKF----AEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPAN 148
+Q+L K A + +E++E + K ++ + H+ S + GP
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 149 THLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTAL------------------ 190
L++E KL+ + E L+ R S A +AL
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Query: 191 -----------------QESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINR--- 230
Q+ + + ++WK Q + R E +R + I LEE+ S +NR
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242
Query: 231 EKEKNTQLKRRIEELEAELREK-ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 289
EKE ++ +R+ E+E +K E L+ + + E S AAER +
Sbjct: 1243 EKEGESKELKRLVMAESEKSQKLEERLR------------LLQAETASNSARAAERSSA- 1289
Query: 290 LEDKVRSLKTDIEESKYRQRHLKVELKSFLE 320
L ++V+SL+ + E+ + +L+ EL S E
Sbjct: 1290 LREEVQSLREEAEKQRVASENLRQELTSQAE 1320
Score = 52.4 bits (124), Expect = 6e-07
Identities = 53/254 (20%), Positives = 112/254 (44%), Gaps = 31/254 (12%)
Query: 104 QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALT 163
QE+ + AK+K + +T QAS E+ S + LK + +LK
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS------LKQKEQQLKEVAE 572
Query: 164 QSAANVKKWEIELQT--------LRESNA---RLTTALQESAASVEQWKRQFSICRDEND 212
+ A + +L T LRE +A +L +E AA +E ++Q + + D
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 213 RLRNKIDELEEQCSEINRE-----------KEKNTQLKRRIEELEAELREKETELKDLRK 261
+ + + + + +E++R+ +++ + + ++ ELE +LR ++ + + +
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 321
++ QL + + + E L+ + +LE++ R +EE + LK E +S +E
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTK---GSLEEEKRRAADALEEQQRCISELKAETRSLVEQ 749
Query: 322 LDGKIDDLHDFRRG 335
+ +L + R G
Sbjct: 750 HKRERKELEEERAG 763
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/164 (21%), Positives = 83/164 (50%), Gaps = 13/164 (7%)
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+S D+L++ L ++ + + + ++ +++ RL ++ AAS + K + RD+N
Sbjct: 227 RSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK-ELEELRDKN 285
Query: 212 DRLRNKIDELEEQCSEINREK-----------EKNTQLKRRIEELEAELREKETELKDLR 260
+ L ++ E +QC ++ EK E+N L ++ E + L++ + L +L
Sbjct: 286 ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345
Query: 261 KQ-SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEE 303
++ S+ + + + + ++L AA +D + LE+K L+ + +
Sbjct: 346 EEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ 389
Score = 47.4 bits (111), Expect = 2e-05
Identities = 58/242 (23%), Positives = 102/242 (42%), Gaps = 48/242 (19%)
Query: 107 KEAAKIAKDKTQEKIETSSN------HSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
K+AA + K E++ + H EK+ N L EN L
Sbjct: 267 KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKIN-QLSEENGDLSF 325
Query: 161 ALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR---QFSICRDE-NDRLRN 216
L + A+++++ + L L E +++ T E A +E+ Q C +E N+ L+
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQG 385
Query: 217 KIDELEEQCSEI--NREKEK-----------------------NTQLKRRIEELEAELRE 251
K+ +LEE S++ N +EK NTQL+ R+E LE E +
Sbjct: 386 KLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQ 445
Query: 252 KETEL--------KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQ----NLEDKVRSLKT 299
+E +L ++ ++ S +I L S +S+ E E+ +Q L +V SL +
Sbjct: 446 QEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 505
Query: 300 DI 301
++
Sbjct: 506 EL 507
Score = 46.6 bits (109), Expect = 3e-05
Identities = 47/219 (21%), Positives = 102/219 (46%), Gaps = 29/219 (13%)
Query: 107 KEAAKIAKDKTQ-----EKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
+EAA +A + TQ E +ET +A + H + E +L
Sbjct: 420 QEAATLAANNTQLQARVEMLETERGQQEAKLL------------AERGHFEEEKQQLSSL 467
Query: 162 LTQ---SAANVKKWEIELQTLRESN-ARLTTALQESAASVEQWKRQFSICRDENDRLRNK 217
+T S +N+ + + EL+ +++ ARLT + + + E L+ +
Sbjct: 468 ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527
Query: 218 IDELEEQCSEINREKEKNTQ-LKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYV 276
E + Q ++ +++E+ +Q L+ ++E+L + L++KE +LK++ ++ E Q ++
Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ-----DHA 582
Query: 277 SEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
+ AAE +L ++ +LK E+ +++ K+E+
Sbjct: 583 QQLATAAEEREASLRERDAALKQ--LEALEKEKAAKLEI 619
Score = 41.2 bits (95), Expect = 0.001
Identities = 49/243 (20%), Positives = 101/243 (41%), Gaps = 30/243 (12%)
Query: 100 AEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLK 159
AE ++V+E + QE+ E + ++ ++ +KA+ + E D+L+
Sbjct: 646 AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE----KERVAQEKDQLQ 701
Query: 160 IALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKID 219
L ++K + +L E R AL+E + + K + +++ R R +++
Sbjct: 702 EQLQALKESLK---VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 220 E-------LEEQCSEINREKEKNTQ-LKRRIEELEAELREKETELKDLRKQ-----SEII 266
E LE + ++ + T+ L+R + E A E+E + L K+
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
Query: 267 PQLMSECEY----------VSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 316
E +Y + E+ E A ++ Q ++KV +++ E RQ++ EL
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
Query: 317 SFL 319
+ L
Sbjct: 879 ANL 881
Score = 41.2 bits (95), Expect = 0.001
Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 29/240 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E +L + EK+ V+E A + D E S+ + A + G A +
Sbjct: 1466 EVELDQAREKY--VQELAAVRADAETRLAEVQ--REAQSTARELEVMTAKYEG-AKVKVL 1520
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQES--AASVEQWK-----RQFS 205
E + + + A V++ E+ + + L+ L +S A+ V+Q K Q
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGG 1580
Query: 206 ICRDENDRLRNKIDELEEQCSE---------INREKEKN--TQLKRRIEELEAELREKE- 253
+ E RL+ +++EL+ Q S+ + EK K K++ +EL+ +LR E
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
Query: 254 --TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHL 311
E K+LR ++E +L E + K + AE+ ++L +VRSL+ + + + R L
Sbjct: 1641 LQKENKELRAEAE---RLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 40.4 bits (93), Expect = 0.002
Identities = 35/172 (20%), Positives = 80/172 (46%), Gaps = 14/172 (8%)
Query: 94 QQLTKFA-EKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
+QL F E+ ++V+E +K D Q + G ++A L+
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR-------LQ 1590
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLR---ESNARLTTALQESAASVEQWKRQFSICRD 209
++ ++L+ L+Q + ++++++ + ++ + LQE S+EQ +++ R
Sbjct: 1591 AQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650
Query: 210 ENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRK 261
E +RL + EL++ + ++ L ++ LEA++ + +L+DL K
Sbjct: 1651 EAERLGH---ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/259 (19%), Positives = 111/259 (42%), Gaps = 22/259 (8%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
++++L + Q+V E + A+ EK + S +G E+ G
Sbjct: 1402 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE---RA 1458
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
L++ L Q+ +K+ EL +R A T L E + R+ + +
Sbjct: 1459 NLGRQFLEVELDQAR---EKYVQELAAVR---ADAETRLAEVQREAQSTARELEVMTAKY 1512
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
+ + K+ LEE+ R +E+ +L ++E+LE RE+ ++++L K+ Q
Sbjct: 1513 EGAKVKV--LEER----QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 272 ECEYVSEKLEA----AERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK-- 325
+ + ++A ++++ Q L+ ++ L+ + + + H K++++ D K
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 326 -IDDLHDFRRGLSKLGTDN 343
+L + R L +L +N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645
Score = 33.5 bits (75), Expect = 0.28
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 7/122 (5%)
Query: 219 DELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSE 278
D L+ ++ R K++ + +ELE EL E L + Q ++ Q + ++E
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 279 KLEAAERDNQNLE---DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRG 335
K A+ + + LE DK SL + E+ + + LK E +D KI+ L +
Sbjct: 267 KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ----MDRKINQLSEENGD 322
Query: 336 LS 337
LS
Sbjct: 323 LS 324
Score = 33.1 bits (74), Expect = 0.37
Identities = 47/221 (21%), Positives = 89/221 (40%), Gaps = 26/221 (11%)
Query: 104 QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPA-------NTHLKSEND 156
Q+ E ++A++K Q + + + G+ +E+ A A + LK+E
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 157 KL-------KIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRD 209
L + L + A K E LQ L E++ T L+ A E Q +
Sbjct: 745 SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA--EAMAAQHT-AES 801
Query: 210 ENDRLRNKIDELEEQCSEINRE--------KEKNTQLKRRIEELEAELREKETELKDLRK 261
E ++L ++ E+ + +E +E+ LK E+ EL+E + ++ +
Sbjct: 802 ECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIES 861
Query: 262 QSEI-IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 301
SE+ I + +E + L A + Q E + + L D+
Sbjct: 862 HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 56.2 bits (134), Expect = 4e-08
Identities = 55/232 (23%), Positives = 102/232 (43%), Gaps = 35/232 (15%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
S+Q T+ E+ + E AK+ ++ SS H ++E+ A
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALAHALQ-SSRHDCDLLREQYEEEQEGKA------- 1356
Query: 152 KSENDKLKIALTQSAANVKKWEIELQT--------LRESNARLTTALQESAASVEQWKRQ 203
+L+ AL+++ + V +W + +T L E+ +L LQ+S VE +
Sbjct: 1357 -----ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAK 1411
Query: 204 FSICRDENDRLRNKIDELEEQCSEINR------EKEKN-----TQLKRRIEELEAELREK 252
+ RL+ ++++L N +K++N + K + EE +AEL
Sbjct: 1412 CASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL--- 1468
Query: 253 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
E LK+ R S + +L + E ++LE +R+N+NLE ++ L I E+
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520
Score = 54.7 bits (130), Expect = 1e-07
Identities = 62/263 (23%), Positives = 116/263 (44%), Gaps = 28/263 (10%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH 150
++E ++ E+ + E IAK T+EK H QA +++K + +
Sbjct: 971 ATENKVKNLTEELSGLDET--IAK-LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK 1027
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
L+ + + L+ +L Q KK ++L+ + QES +E K+Q
Sbjct: 1028 LEQQVEDLESSLEQE----KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL------ 1077
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEII 266
++RL+ K E + S++ E+ Q +++I+EL+A + E E E++ R K +
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137
Query: 267 PQLMSECEYVSEKLEAAE-------RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK--- 316
E E +SE+LE A N+ E + L+ D+EE+ + + L+
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKH 1197
Query: 317 -SFLEVLDGKIDDLHDFRRGLSK 338
+ L +ID+L ++ L K
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEK 1220
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/259 (19%), Positives = 116/259 (44%), Gaps = 35/259 (13%)
Query: 108 EAAKIAKD-KTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN---DKLKIALT 163
EA ++++ + +E I + + S+ + T++ K L+ EN + L AL
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ--------LEEENKAKNALAHALQ 1335
Query: 164 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQF---SICRDEN-----DRLR 215
S + + + +E A L AL ++ + V QW+ ++ +I R E +L
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395
Query: 216 NKIDELEEQCSEINRE----KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMS 271
++ + EEQ +N + ++ +L+ +E+L ++ + L K+ ++++
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 272 E----CEYVSEKLEAAERDNQNLEDKVRSLKTDIEES-------KYRQRHLKVELKSFLE 320
E CE +LEA+ +++++L ++ LK EE+ K ++L+ E+ E
Sbjct: 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515
Query: 321 VLDGKIDDLHDFRRGLSKL 339
+ +H+ + ++
Sbjct: 1516 QIAENGKTIHELEKSRKQI 1534
Score = 46.2 bits (108), Expect = 4e-05
Identities = 54/244 (22%), Positives = 103/244 (42%), Gaps = 16/244 (6%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKAS--HAGPANT 149
+E+Q + +A + +E+ E + A T +IE + D E+A+ H
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192
Query: 150 HLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFS-ICR 208
K D + L + N+++ + +L+ + L S SV + K ICR
Sbjct: 1193 LRKKHADSVA-ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 209 DENDRL---RNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEI 265
D+L R K +E++ SE+ +K + L+ EL +L EKE+ + L + +
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSR---LQTEAGELSRQLEEKESIVSQLSRSKQA 1308
Query: 266 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD---IEESKYRQRHLKVELKSFLEVL 322
Q + E + +LE + L ++S + D + E ++ K EL+ L
Sbjct: 1309 FTQ---QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA 1365
Query: 323 DGKI 326
+ ++
Sbjct: 1366 NSEV 1369
Score = 43.5 bits (101), Expect = 3e-04
Identities = 55/227 (24%), Positives = 95/227 (41%), Gaps = 16/227 (7%)
Query: 111 KIA-KDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
KIA KD+ E+++ + + + + D E S K E D +I + S AN
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 1635
Query: 170 KKWEIELQTLRESNARLTTA---LQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCS 226
+ E L+ LR +L L ++ E K Q +I + L+ +++EL
Sbjct: 1636 QAAET-LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Query: 227 EINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEI-IPQLMSECEYVSEKLEAAER 285
+ R ++ Q E L + T L +K+ E + QL SE +E A R
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSE-------VEDASR 1747
Query: 286 DNQNLEDKVRSLKTD---IEESKYRQRHLKVELKSFLEVLDGKIDDL 329
D +N E+K + TD + E +++ L+ + L+ + DL
Sbjct: 1748 DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1794
Score = 42.0 bits (97), Expect = 8e-04
Identities = 42/189 (22%), Positives = 83/189 (43%), Gaps = 13/189 (6%)
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDE 210
+K E K K L +S A K+ E +L TL + L +Q + ++ +
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD-------AEER 905
Query: 211 NDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM 270
D+L +LE + E+ E ++ EL A+ R+ E E +L+K + + +
Sbjct: 906 CDQLIKAKFQLEAKIKEVTERAEDEEEIN---AELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLH 330
++ V ++ A E +NL +++ L I + ++ L+ + L+ L + D ++
Sbjct: 963 AK---VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVN 1019
Query: 331 DFRRGLSKL 339
+ SKL
Sbjct: 1020 SLNKTKSKL 1028
Score = 40.0 bits (92), Expect = 0.003
Identities = 46/215 (21%), Positives = 91/215 (42%), Gaps = 18/215 (8%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
Q TK+ + E + AK K ++++ S +A + EK L+
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ------RLQG 1424
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
E + L + + ++ + + + + + A T +ES A +E ++ E +
Sbjct: 1425 EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK 1484
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKET---ELKDLRKQSEIIPQLM 270
L+N +E +Q + RE N L++ I +L ++ E EL+ RKQ E+
Sbjct: 1485 LKNAYEEALDQLETVKRE---NKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL----- 1536
Query: 271 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 305
E + LE AE ++ E K+ ++ ++ + K
Sbjct: 1537 -EKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Score = 39.3 bits (90), Expect = 0.005
Identities = 37/232 (15%), Positives = 106/232 (45%), Gaps = 14/232 (6%)
Query: 96 LTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSV------NGTDD--EKASHAGPA 147
L K F +V K +++Q ++E S S++ S N ++ ++
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Query: 148 NTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSIC 207
N +L+ E L + ++ + + E + + A + AL+E+ A++E + +
Sbjct: 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Query: 208 RDENDRLRNKID----ELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQS 263
+ E +++++ID E +E+ ++ R ++ + + L+AE+R + ++ +K
Sbjct: 1563 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ--SALDAEVRSRNEAIRLKKKME 1620
Query: 264 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL 315
+ ++ + + + + + ++++ +++ + ++++ Q LK +L
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672
Score = 37.7 bits (86), Expect = 0.015
Identities = 46/224 (20%), Positives = 99/224 (44%), Gaps = 32/224 (14%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIE-TSSNHSQASSVNGTDD-------EKASHA 144
+ ++ + ++ + A K+A+ + + E H+Q +S+ T + S
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742
Query: 145 GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQF 204
A+ ++ +K K A+T +A ++ + E Q+++A +E+ K+
Sbjct: 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKE---------------QDTSAHLERMKKNL 1787
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAEL----REKETELKDLR 260
+ L++++DE E+ + K++ +L+ RI ELE EL ++ +K LR
Sbjct: 1788 EQTVKD---LQHRLDEAEQLA--LKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLR 1842
Query: 261 KQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
K + +L + E + + + L+ KV+S K EE+
Sbjct: 1843 KYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEA 1886
Score = 34.3 bits (77), Expect = 0.17
Identities = 37/142 (26%), Positives = 62/142 (43%), Gaps = 9/142 (6%)
Query: 164 QSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEE 223
+S NVK W ++ + L +A E+ + K +F +DE + K ELEE
Sbjct: 820 RSFMNVKHWPW-MKLFFKIKPLLKSA--ETEKEMATMKEEFQKTKDELAKSEAKRKELEE 876
Query: 224 QCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAA 283
+ + +EK L+ +++ L + E L K QL ++ + V+E+ E
Sbjct: 877 KLVTLVQEK---NDLQLQVQAESENLLDAEERCDQLIKAKF---QLEAKIKEVTERAEDE 930
Query: 284 ERDNQNLEDKVRSLKTDIEESK 305
E N L K R L+ + E K
Sbjct: 931 EEINAELTAKKRKLEDECSELK 952
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.2 bits (134), Expect = 4e-08
Identities = 61/267 (22%), Positives = 121/267 (45%), Gaps = 32/267 (11%)
Query: 92 SEQQLTKFAEKF----QEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPA 147
+E++ KFA+ ++++ ++ +++T++K+ SS Q + E+ A
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 148 NTHLKSENDKLKIALTQSAANVKKW------------EIELQTLRESNARLTTALQESAA 195
+L +K +AL A+ KK E + + L+++ A L+ L+E A
Sbjct: 1359 RKNL----EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKAL 1413
Query: 196 SVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQL--------KRRIEE--- 244
+ ++ ++ + + E D L +D + S + ++++K QL R EE
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Query: 245 LEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
EAE REKET+ L + E + E E +++L A D + +D V ++E+S
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533
Query: 305 KYRQRHLKVELKSFLEVLDGKIDDLHD 331
K E+++ LE L+ ++ D
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATED 1560
Score = 54.3 bits (129), Expect = 2e-07
Identities = 59/246 (23%), Positives = 111/246 (45%), Gaps = 30/246 (12%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
++++L K AE + E +A DK +E + N Q + T D H ++L
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDK----LEKTKNRLQQELDDLTVD--LDHQRQVASNL 1446
Query: 152 KSENDKLKIALTQSAANVKKW-------EIELQTLRESNARLTTALQESAASVEQWKRQF 204
+ + K L + + ++ E E + L AL+E+ + E+++RQ
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 205 SICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETEL---KDLRK 261
R + + L + D++ + E+ + K L++++EE+ +L E E EL +D +
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKR---ALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDK------VRSLKTDIEESKYRQRHLKVEL 315
+ E+ Q M + + RD QN E K VR L+ ++E+ + +QR L V
Sbjct: 1564 RLEVNMQAMK----AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER-KQRALAVAS 1618
Query: 316 KSFLEV 321
K +E+
Sbjct: 1619 KKKMEI 1624
Score = 53.5 bits (127), Expect = 3e-07
Identities = 53/243 (21%), Positives = 109/243 (44%), Gaps = 25/243 (10%)
Query: 95 QLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKA-SHAGPANTHLKS 153
Q+T+ E+ Q E K+K Q K+E + +++ + A T L +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 154 ENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDR 213
E ++++ L KK E+E L + + VE+ + + I ++E +
Sbjct: 905 EAEEMRARLA-----AKKQELE------------EILHDLESRVEEEEERNQILQNEKKK 947
Query: 214 LRNKIDELEEQCSEINREKEKNTQLKR-----RIEELEAELREKETELKDLRKQSEIIPQ 268
++ I +LEEQ E ++K QL++ +I+++E E+ E + K+ +++
Sbjct: 948 MQAHIQDLEEQLDEEEGARQK-LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 269 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 328
++EC + E ++ + +K + +D+EE ++ + EL+ LDG+ D
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 329 LHD 331
L D
Sbjct: 1067 LQD 1069
Score = 50.1 bits (118), Expect = 3e-06
Identities = 63/267 (23%), Positives = 113/267 (42%), Gaps = 35/267 (13%)
Query: 103 FQEVKEAAKIAKDK--TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
+Q E A+ ++D+ Q K S + + +E AS + A H + E D+L
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS-SERARRHAEQERDELAD 1715
Query: 161 ALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDE 220
+T SA+ E + L A+L L+E +++E +F + D L E
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN---AE 1772
Query: 221 LEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQS-----EIIPQLMSECEY 275
L + S + QL+R+ +EL+A+L+E E +K K + I QL + E
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 276 VSEKLEAAERDNQNLEDKVRSL--------------KTDIEESKYRQRHLKVELKSFLE- 320
+++ AA + + E K++ + K +E++ R + LK +L+ E
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 321 ---------VLDGKIDDLHDFRRGLSK 338
L ++DD + GLS+
Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSR 1919
Score = 48.1 bits (113), Expect = 1e-05
Identities = 36/141 (25%), Positives = 77/141 (54%), Gaps = 7/141 (4%)
Query: 199 QWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKD 258
QW R F+ + R + +EL+ + E+ + KEK T+++ +EE+E + ++ E
Sbjct: 833 QWWRVFTKVKPLLQVTRQE-EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 259 LRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHL---KVEL 315
L +Q + +L +E E + +L A + Q LE+ + L++ +EE + R + L K ++
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKK---QELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 316 KSFLEVLDGKIDDLHDFRRGL 336
++ ++ L+ ++D+ R+ L
Sbjct: 949 QAHIQDLEEQLDEEEGARQKL 969
Score = 46.6 bits (109), Expect = 3e-05
Identities = 53/259 (20%), Positives = 105/259 (40%), Gaps = 52/259 (20%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
+E+ + A K QE++E + + +E+ E + + + +H L
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQ------ILQNEKKKMQAHIQDLEEQL 959
Query: 152 KSEN---DKLKIALTQSAANVKKWEIELQTLRESNA-----------RLTTALQESAASV 197
E KL++ + A +KK E E+ L + N+ R+ + A
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 198 EQWKRQFSI--------------------CRDENDRLRNKID----ELEEQCSEINRE-K 232
E+ K I R E ++ + K+D +L++Q +E+ +
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 233 EKNTQLKRRIEELEAELREKETE-------LKDLRKQSEIIPQLMSECEYVSEKLEAAER 285
E QL ++ EEL+ L + E LK +R+ I +L + E AE+
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 286 DNQNLEDKVRSLKTDIEES 304
++L +++ +LKT++E++
Sbjct: 1140 QKRDLSEELEALKTELEDT 1158
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/167 (22%), Positives = 84/167 (50%), Gaps = 19/167 (11%)
Query: 153 SENDKLKIALTQSAANVKKWEIELQTLRESNAR----LTTALQESAASVEQWKRQFSICR 208
+E+ KL++ + A + +E +LQT E N L ++E A +E ++Q ++
Sbjct: 1558 TEDAKLRLEVNMQAMKAQ-FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 209 DENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLR-------- 260
++ + +LE Q N+ ++ ++ +++ +L+A++++ + EL++ R
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARD---EVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 261 --KQSEI-IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 304
K+SE + L +E + E+L ++ER ++ E + L +I S
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Score = 42.7 bits (99), Expect = 5e-04
Identities = 57/266 (21%), Positives = 106/266 (39%), Gaps = 24/266 (9%)
Query: 69 KTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHS 128
+T Q D R L SEQ + A++F+ E K + +++
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQ--LEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 129 QASSVNGTDDEKASHAGPANTHLK-SENDKLKIALTQSAANVKKWEIELQTLRESNARLT 187
Q K A H K SE D+L++ L + A+ ++ + TL E +
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 188 TALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEA 247
+ AAS+E +++ + +E E R+K + R++EE +
Sbjct: 1304 IKFAKDAASLE-----------------SQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 248 ELREKETELKDLRKQSE-IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKY 306
L+E++ E ++ RK E + L S+ +K++ ++LE+ + L D E
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 307 RQRHLKV---ELKSFLEVLDGKIDDL 329
R + +L+ L ++DDL
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDL 1432
Score = 42.4 bits (98), Expect = 6e-04
Identities = 62/251 (24%), Positives = 101/251 (40%), Gaps = 39/251 (15%)
Query: 98 KFAEKFQEVKEAAKIAKDKTQEKIETSS--NHSQASSVNGTDD---EKASH--AGPANTH 150
+ A+K +E++ A D+T K QA +D EKAS A
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 151 LKSENDKLKIALTQSAANVKKWEIELQTLRESN-ARLTTALQESAASVEQWKRQFSICRD 209
L E + LK L + + + EL+T RE A L AL+E + E + +D
Sbjct: 1144 LSEELEALKTEL-EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE------AQIQD 1196
Query: 210 ENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQL 269
R ++EL EQ + R K LE + ET+ K+L + +++ Q+
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKAN----------LEKNKQGLETDNKELACEVKVLQQV 1246
Query: 270 MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 329
+E E+ +KL+A +V+ L + E L+VEL L ++D++
Sbjct: 1247 KAESEHKRKKLDA----------QVQELHAKVSEGD----RLRVELAEKASKLQNELDNV 1292
Query: 330 HDFRRGLSKLG 340
K G
Sbjct: 1293 STLLEEAEKKG 1303
Score = 42.0 bits (97), Expect = 8e-04
Identities = 52/247 (21%), Positives = 100/247 (40%), Gaps = 42/247 (17%)
Query: 93 EQQLTKFAEKFQEVKE-AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E++ KF + E K +A+ A+++ + + E ++A S+ +E A A
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE----ALEAKEEF 1502
Query: 152 KSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+ +N +L+ + ++ + L +S L ++E +E+ + + D
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 212 DRLRNKIDELEEQCS-EINREKEKNTQLKR----RIEELEAELREK-------------- 252
RL + ++ Q ++ E+N + KR ++ ELEAEL ++
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 253 ETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN------------------LEDKV 294
E +LKDL Q E + E KL+A +D Q E K+
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 295 RSLKTDI 301
+SL+ +I
Sbjct: 1683 KSLEAEI 1689
Score = 37.0 bits (84), Expect = 0.026
Identities = 41/228 (17%), Positives = 96/228 (42%), Gaps = 21/228 (9%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E ++ + E+ +E + ++ D+ ++ T+ ++ + A + A L+
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRK---TTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 153 SENDKLKIALTQSAANVK-KWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDEN 211
+N +LK L + VK K++ + L +L L++ A N
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA----------AN 1841
Query: 212 DRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII----P 267
+R +L+E ++ E+ Q K ++E+ A +++ + +L++ +++
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRR 1901
Query: 268 QLMSECEYVSEKLEAAERDNQNLEDKVR---SLKTDIEESKYRQRHLK 312
+L E + +E E R+ L++++R + S RQ HL+
Sbjct: 1902 KLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLE 1949
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,165,760
Number of Sequences: 37866
Number of extensions: 460067
Number of successful extensions: 10614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 471
Number of HSP's successfully gapped in prelim test: 888
Number of HSP's that attempted gapping in prelim test: 3702
Number of HSP's gapped (non-prelim): 4352
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.