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Search of human proteins with 13259510
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
(1278 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 2461 0.0
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 2393 0.0
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 2189 0.0
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 2174 0.0
gi|4506751 restin isoform a [Homo sapiens] 127 9e-29
gi|38044112 restin isoform b [Homo sapiens] 125 2e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens] 106 1e-22
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 103 8e-22
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 103 8e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 99 2e-20
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 3e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 99 3e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 96 2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 96 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 96 2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 96 2e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 95 5e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 5e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 5e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 6e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 94 8e-19
gi|16262452 cingulin [Homo sapiens] 94 1e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 92 4e-18
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 5e-18
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 91 5e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 91 5e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 91 5e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 91 5e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 91 5e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 91 5e-18
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 2461 bits (6377), Expect = 0.0
Identities = 1278/1278 (100%), Positives = 1278/1278 (100%)
Query: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
Sbjct: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60
Query: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
Sbjct: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120
Query: 121 GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS 180
GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
Sbjct: 121 GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS 180
Query: 181 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 240
SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
Sbjct: 181 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 240
Query: 241 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
Sbjct: 241 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300
Query: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
Sbjct: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360
Query: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
Sbjct: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420
Query: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
Sbjct: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480
Query: 481 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 540
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
Sbjct: 481 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 540
Query: 541 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 600
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
Sbjct: 541 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 600
Query: 601 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 660
GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
Sbjct: 601 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 660
Query: 661 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 720
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
Sbjct: 661 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 720
Query: 721 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 780
TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
Sbjct: 721 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 780
Query: 781 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 840
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
Sbjct: 781 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 840
Query: 841 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 900
LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
Sbjct: 841 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 900
Query: 901 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 960
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
Sbjct: 901 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 960
Query: 961 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1020
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
Sbjct: 961 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1020
Query: 1021 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS 1080
ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS
Sbjct: 1021 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS 1080
Query: 1081 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1140
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
Sbjct: 1081 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1140
Query: 1141 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1200
SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
Sbjct: 1141 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1200
Query: 1201 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1260
KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
Sbjct: 1201 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1260
Query: 1261 RLVLTQEQLHQLHSRLIS 1278
RLVLTQEQLHQLHSRLIS
Sbjct: 1261 RLVLTQEQLHQLHSRLIS 1278
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 2393 bits (6201), Expect = 0.0
Identities = 1253/1278 (98%), Positives = 1253/1278 (98%), Gaps = 25/1278 (1%)
Query: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
Sbjct: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60
Query: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
Sbjct: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120
Query: 121 GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS 180
GTDTTAKTSKL PTRPASTGVAGASSSLGPSGSASAGELSS
Sbjct: 121 GTDTTAKTSKL--------------------PTRPASTGVAGASSSLGPSGSASAGELSS 160
Query: 181 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 240
SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
Sbjct: 161 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 220
Query: 241 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
Sbjct: 221 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 280
Query: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
Sbjct: 281 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 340
Query: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
Sbjct: 341 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 400
Query: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
Sbjct: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 460
Query: 481 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 540
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
Sbjct: 461 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 520
Query: 541 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 600
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
Sbjct: 521 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 580
Query: 601 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 660
GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
Sbjct: 581 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 640
Query: 661 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 720
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
Sbjct: 641 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 700
Query: 721 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 780
TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
Sbjct: 701 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 760
Query: 781 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 840
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
Sbjct: 761 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 820
Query: 841 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 900
LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
Sbjct: 821 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 880
Query: 901 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 960
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
Sbjct: 881 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 940
Query: 961 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1020
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
Sbjct: 941 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1000
Query: 1021 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS 1080
ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAG GAIPGQAPGS
Sbjct: 1001 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGS 1055
Query: 1081 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1140
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
Sbjct: 1056 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1115
Query: 1141 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1200
SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
Sbjct: 1116 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1175
Query: 1201 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1260
KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
Sbjct: 1176 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1235
Query: 1261 RLVLTQEQLHQLHSRLIS 1278
RLVLTQEQLHQLHSRLIS
Sbjct: 1236 RLVLTQEQLHQLHSRLIS 1253
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 2189 bits (5673), Expect = 0.0
Identities = 1140/1142 (99%), Positives = 1142/1142 (100%)
Query: 137 KKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 196
++APTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII
Sbjct: 3 RQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 62
Query: 197 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 256
PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE
Sbjct: 63 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 122
Query: 257 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE
Sbjct: 123 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
Query: 317 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 376
RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR
Sbjct: 183 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA
Sbjct: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 556
REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
Query: 557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 616
IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI
Sbjct: 423 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
Query: 617 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 676
CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ
Sbjct: 483 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 542
Query: 677 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 736
CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA
Sbjct: 543 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 602
Query: 737 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 796
EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ
Sbjct: 603 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 662
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 856
FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA
Sbjct: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 722
Query: 857 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 916
ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER
Sbjct: 723 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 782
Query: 917 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 976
PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL
Sbjct: 783 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
Query: 977 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR
Sbjct: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
Query: 1037 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 1096
LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ
Sbjct: 903 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 962
Query: 1097 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1156
ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL
Sbjct: 963 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1022
Query: 1157 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1216
ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG
Sbjct: 1023 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1082
Query: 1217 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1276
ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL
Sbjct: 1083 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1142
Query: 1277 IS 1278
IS
Sbjct: 1143 IS 1144
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 2174 bits (5632), Expect = 0.0
Identities = 1135/1142 (99%), Positives = 1137/1142 (99%), Gaps = 5/1142 (0%)
Query: 137 KKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 196
++APTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII
Sbjct: 3 RQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 62
Query: 197 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 256
PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE
Sbjct: 63 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 122
Query: 257 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE
Sbjct: 123 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
Query: 317 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 376
RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR
Sbjct: 183 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA
Sbjct: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 556
REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
Query: 557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 616
IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI
Sbjct: 423 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
Query: 617 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 676
CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ
Sbjct: 483 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 542
Query: 677 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 736
CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA
Sbjct: 543 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 602
Query: 737 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 796
EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ
Sbjct: 603 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 662
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 856
FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA
Sbjct: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 722
Query: 857 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 916
ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER
Sbjct: 723 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 782
Query: 917 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 976
PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL
Sbjct: 783 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
Query: 977 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR
Sbjct: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
Query: 1037 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 1096
LNSQSKRTIEGLRGPPPSGIATLVSGIAG GAIPGQAPGSVPGPGLVKDSPLLLQQ
Sbjct: 903 LNSQSKRTIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLLQQ 957
Query: 1097 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1156
ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL
Sbjct: 958 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1017
Query: 1157 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1216
ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG
Sbjct: 1018 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1077
Query: 1217 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1276
ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL
Sbjct: 1078 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1137
Query: 1277 IS 1278
IS
Sbjct: 1138 IS 1139
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 127 bits (318), Expect = 9e-29
Identities = 223/1097 (20%), Positives = 454/1097 (41%), Gaps = 125/1097 (11%)
Query: 19 SAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKY 78
S + R L++G RV ++G G V ++G T FA G+W GV LDE GKNDG V G +Y
Sbjct: 204 SIKKGERELKIGDRV-LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 262
Query: 79 FTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKK 138
F C +G+F +V + G +T TP + + ++R T+A + P
Sbjct: 263 FQCQPKYGLFAPVH--KVTKIGFPST---TPAKAKANAVRRVMATTSASLKR----SPSA 313
Query: 139 APTARKTTTRRPKPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTPAQTPLAAPI 195
+ + ++ +RP+ TG+ +SS SG+ + E + Q +
Sbjct: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDL 373
Query: 196 IPTPVLTSPGAVPPLPSP-SKEEEGLRAQVRDLEEKLETLR-LKRAEDKAK---LKELEK 250
V + V + + +G V +LE K++ LR + A D+ K L +LE+
Sbjct: 374 ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEE 433
Query: 251 HKIQLEQVQEWKSKMQEQQADL--QRRLKEAR-KEAKEALEAKERYMEEMADTADAIEMA 307
K ++E +Q + + DL Q +L+ AR KE +++L ++ +++ + +A
Sbjct: 434 EKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493
Query: 308 TLDKE---MAEERAESLQ-QEVEALKERVD------------ELTTDLEILKAEIEEKGS 351
T+ ++ M E+ +L+ QEV L+ R++ L ++ L+ ++E +
Sbjct: 494 TVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 553
Query: 352 DGAASSYQLKQ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE-LEVVR 406
D LK+ EE + + AL + S E + L+ +E N+E +V+
Sbjct: 554 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENE---SLKSKLEHANKENSDVIA 610
Query: 407 QQRERLQEELSQAESTIDELKEQVDAALGAE-----EMVEMLTDRNLNLEEKVRELR--- 458
+ +L+ ++ + ++ELK LG E E+ + L+ + ++ L+
Sbjct: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
Query: 459 --ETVGDLEAMNEMNDELQENARETELEL---REQLDMAG----ARVREAQKRVEAAQET 509
E + M + +L + +E E L R +LD A + + +++ A+
Sbjct: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
V + + K + T + + +L +E ++ + + K + + + +A
Sbjct: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS-EGKSEMKKLRQQLEAA 789
Query: 570 EMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEK 629
E +++ +E+ + N S ++ + R L L + + + +++ +++
Sbjct: 790 EKQIKHLEI-EKNAESSKASSITRELQGRE-------LKLTNLQENLSEVSQVKETLEKE 841
Query: 630 FELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLY 689
++ L+ E A + S+ LH+ E + S D+ +K+
Sbjct: 842 LQI---------LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL-EKLRENL 891
Query: 690 PEMSAHERSLDFLIELL--HKDQLDETV---------NVEPLTKAIKYYQHLYSIHLAEQ 738
+M A R D E L K++L+ + N LTK + L E+
Sbjct: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND------ELRLKER 945
Query: 739 P-EDCTMQLA---DHIKFTQSALDCMSV--EVGRLRAFLQGGQEATDIALLLRDLETSCS 792
E+ ++L ++ F Q +++ M+V E + A + +E ++ L DLE
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 1005
Query: 793 DIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLD-------CRKHLTWVVAVLQEVA 845
C++++ R + + TLLD R+ + ++ L+E+
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 846 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS--------SPYECLRQSCNILI 897
A + A + + + +E++ + +E + + + + L+++ +
Sbjct: 1066 KQADKAKAAQTAEDAMQI--MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV 1123
Query: 898 STMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKK 957
+NK + E + ++ AA +++ + +KL + ++
Sbjct: 1124 EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1183
Query: 958 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 1017
S + EE S N +L ++K+ KDADE +Q + T ALL +K+ E E+
Sbjct: 1184 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK--- 1240
Query: 1018 ALQADIDQLEAEKAELK 1034
L+ ++ L E A K
Sbjct: 1241 -LRNEVTVLRGENASAK 1256
Score = 108 bits (271), Expect = 3e-23
Identities = 262/1325 (19%), Positives = 511/1325 (38%), Gaps = 177/1325 (13%)
Query: 10 SRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69
S TPS + E RVG RV V G G + ++G T FA G+W G++LDE GKN
Sbjct: 43 SSTPSSE--TQEEFVDDFRVGERVWVNGN-KPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTS--PETPDSSASKVLKREGTDTTAK 127
DG+V G +YF C+ GIF R S++ D + TP S A+ L +
Sbjct: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
Query: 128 TSKLRGLKPKK--APTARKTTTRRP--KPTRPASTGVAGASSS-----------LGPS-- 170
+ P+K P A++ + P T+ AS ++ S + +G
Sbjct: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
Query: 171 -GSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLP-SPSKEEEGLRAQVRDL- 227
G AG + + A+ + P+ + GAV + + GL A V +
Sbjct: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
Query: 228 ----------EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLK 277
+ K +R A A LK L + S + + + +
Sbjct: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKR-SPSASSLSSMSSVASSVSSRPSRTGLLTE 338
Query: 278 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE---------SLQQEVEAL 328
+ + A++ + E + + IE ++++ ERAE ++QE+
Sbjct: 339 TSSRYARK-ISGTTALQEALKEKQQHIEQLLAERDL--ERAEVAKATSHVGEIEQELALA 395
Query: 329 KERVDELTTDLEILKAEIEEKGSDGAASSYQ-LKQLEEQNARLKDALVRMR-------DL 380
++ D+ +LE ++ + L QLEE+ +++D R+ DL
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE-STIDE----LKEQVDAALG 435
+ K EH ++++L Q L + + ++LQ EL +T+ E ++ + D AL
Sbjct: 456 ETQTKLEHARIKEL----EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALR 511
Query: 436 AEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGAR 495
+E+ E+ R L + ++ ++ L+ ++ + ++L+ + + E+ + GAR
Sbjct: 512 VQEVAEL--RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 496 VREAQKRVEA---AQETVADYQQTIK-KYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551
QK ++A A E ++ +++K K DV ++ E ++ QQ E
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Query: 552 TFDFKIKFAETKAHAKAIEMELR-QMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL 610
K+ F++ A EL+ Q+E + + + R + +
Sbjct: 630 ---LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA 686
Query: 611 LMPRLICKAELIRKQAQEKFELSEN-------------------CSERPGLRGAAGEQLS 651
+ ++I + E + + K + +E+ E L+ EQ
Sbjct: 687 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
Query: 652 FAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFL-IELLHKDQ 710
L + L + AL + S + ++ L ++ A E+ + L IE +
Sbjct: 747 VIDNFTSQLKATEEKLLDLD-ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS 805
Query: 711 LDETVNVEPLTKAIK---YYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRL 767
++ E + +K ++L + ++ + +Q+ KF +++ + +SV+
Sbjct: 806 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE-KFAEASEEAVSVQRSMQ 864
Query: 768 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 827
+ Q+ +L DLE ++ K R + + + L
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK----------------DEREEQL 908
Query: 828 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 887
+ ++ L +A + +++ + + + + L +EEL K ++
Sbjct: 909 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------------ 956
Query: 888 CLRQSCNILISTMNKLATAMQEGEYD-AERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
++ + L ++ + ++ + + A++ + +E + + L ++ + +L+
Sbjct: 957 -ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELK 1015
Query: 947 DR------------ETVIKELKKSL-----KIKG--EELSEANVRLSLLEKKLDSA---- 983
R E +++ L+K+L K+KG EE S L L K+ D A
Sbjct: 1016 ARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1075
Query: 984 -AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLN-SQS 1041
A+DA + +E++ ET A L ++ ++T LQ ++D L+ + + LN S+
Sbjct: 1076 TAEDAMQIMEQMTKEKTETLASL----EDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1131
Query: 1042 KRTIEGLRGPP-PSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAM 1100
T+E + I TL A + QQ A+ + G +D Q++
Sbjct: 1132 LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1191
Query: 1101 RLHIS-----QLQHENSILKGA-QMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1154
R ++ + E+ +K A + KASL + A L+ + E R
Sbjct: 1192 RSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE-----KLRNEVT 1246
Query: 1155 LLETLNQLSTHTHVV------DITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLK 1208
+L N + H V D + K+ QL E QL S S + DE +
Sbjct: 1247 VLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDER 1306
Query: 1209 ETVSQ 1213
SQ
Sbjct: 1307 AQESQ 1311
Score = 80.5 bits (197), Expect = 1e-14
Identities = 93/390 (23%), Positives = 169/390 (43%), Gaps = 61/390 (15%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-KIQLEQVQEWKSKMQEQQADLQ 273
+E++ L ++ DLE+K+ET + E KA+ + K + E++ + +Q+ D +
Sbjct: 988 EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ---NLQKTLLDTE 1044
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMAT----LDKEMAEERAESL-------- 321
+LK AR+E L+ E + + AD A A + A + ++M +E+ E+L
Sbjct: 1045 DKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
Query: 322 -----QQEVEALKER----VDELTTDLEIL----------KAEIEEKGSDGAASSYQLKQ 362
Q E++ LKE V+EL E+L + EIE A S QL
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163
Query: 363 LEEQNARLKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVR---QQRERLQEE 415
L+E+N +L + L R RD +S E++ V +L+E K +E + ++ +++ LQ+
Sbjct: 1164 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
Query: 416 LS-------QAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMN 468
+S + ++ +++L+ +V G + L LE +L V +LE
Sbjct: 1224 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-- 1281
Query: 469 EMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ-----TIKKYRQL 523
+L+EN R+ A R + +++ + D Q+ +K
Sbjct: 1282 ----QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1337
Query: 524 TAHLQDVNRELTNQQEASVERQQQPPPETF 553
A L +L N E+Q + P F
Sbjct: 1338 EAALNGNGDDLNNYDSDDQEKQSKKKPRLF 1367
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 125 bits (315), Expect = 2e-28
Identities = 240/1158 (20%), Positives = 455/1158 (39%), Gaps = 182/1158 (15%)
Query: 19 SAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKY 78
S + R L++G RV ++G G V ++G T FA G+W GV LDE GKNDG V G +Y
Sbjct: 204 SIKKGERELKIGDRV-LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 262
Query: 79 FTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKK 138
F C +G+F +V + G +T TP + + ++R T+A + P
Sbjct: 263 FQCQPKYGLFAPVH--KVTKIGFPST---TPAKAKANAVRRVMATTSASLKR----SPSA 313
Query: 139 APTARKTTTRRPKPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTPAQTPLAAPI 195
+ + ++ +RP+ TG+ +SS SG+ + E + Q +
Sbjct: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDL 373
Query: 196 IPTPVLTSPGAVPPLPSP-SKEEEGLRAQVRDLEEKLETLR-LKRAEDKAK---LKELEK 250
V + V + + +G V +LE K++ LR + A D+ K L +LE+
Sbjct: 374 ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEE 433
Query: 251 HKIQLEQVQ------------------EWKSKMQEQQADLQRRLKEARKEAKEALEAKE- 291
K ++E +Q KS++ E + DL R++E E + LE+ +
Sbjct: 434 EKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV-AELRRRLESNKP 492
Query: 292 --------RYMEEMADTADAIEMATLD--------KEMAEERAESLQQEVEALKERVDEL 335
++E++ + +E+ D KE R E+ Q+E++AL ++L
Sbjct: 493 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 552
Query: 336 TTDLEILKAEIEEKGSDG-------------AASSYQLKQLEE--------------QNA 368
+ + E LK+++E + A +S+Q + +EE + A
Sbjct: 553 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ-QAMEELKVSFSKGLGTETAEFA 611
Query: 369 RLKDALVRMR-----------DLSSSEKQEH--------VKLQKLMEKKNQELEVVRQQR 409
LK + +MR + SE+ H KL K++++K LE +R +
Sbjct: 612 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671
Query: 410 ERLQEE-LSQAESTIDELKEQVDAALGAEEMVEMLTDRNL------NLEEKVRELRETVG 462
++ +++ L + E T+++L+E A + +E+ + N N +++ E +
Sbjct: 672 DKAEDQHLVEMEDTLNKLQE---AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL 728
Query: 463 DLEAMNEMNDELQENARETELELREQLDMAGARVR--EAQKRVEAAQETVADYQQTIKKY 520
DL+A+ + + E + + +LR+QL+ A +++ E +K E++ K
Sbjct: 729 DLDALRKASSEGKSEMK----KLRQQLEAAEKQIKHLEIEKNAESS------------KA 772
Query: 521 RQLTAHLQDVNRELTNQQEASVERQQQPPPETFD-----FKIKFAETKAHAKAIEMELRQ 575
+T LQ +LTN QE E Q ET + K KFAE A +++ +++
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQ--VKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 576 M--EVAQANRHMSLLTAFMP---------DSFLRPGGDHDCVLVLLLMPRLICKAELIRK 624
++ Q ++L++ + ++ R + + L+ AE+++
Sbjct: 831 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKM 890
Query: 625 QAQEKFELSE-NCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 683
+L++ N R R QL + S LQ ++ Q + K
Sbjct: 891 SGDNSSQLTKMNDELRLKERDVEELQLKLTKA-NENASFLQKSIEDMTVKAEQSQQEAAK 949
Query: 684 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
K E+ L+ +E H + E T K + + +
Sbjct: 950 KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE----EILQNLQKTL 1005
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRA---FLQGGQEATDIALLLRDLE-------TSCSD 793
+ D +K + + E+ LR + Q A D ++ + S D
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+Q K++ + + + L ++ LT ++E L
Sbjct: 1066 TKQTNAKLQNELDTLKENNLKNV--------EELNKSKELLTVENQKMEEFRKEIETLKQ 1117
Query: 854 PLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYD 913
A+ L A EE A E + ++ L + ++L + + ++ + D
Sbjct: 1118 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD 1177
Query: 914 A-ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIK---ELKKSLKIKGEELSEA 969
A E S + + +A L + + E KL + TV++ KSL + L
Sbjct: 1178 ADEEKASLQKSISITSALLTEKDAELE----KLRNEVTVLRGENASAKSLHSVVQTLESD 1233
Query: 970 NVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAE 1029
V+L L K L+ K E ++ + T + E+ E +D L + I L+ +
Sbjct: 1234 KVKLELKVKNLELQLK---ENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1290
Query: 1030 KAELKQRLNSQSKRTIEG 1047
+LK ++ S+ + G
Sbjct: 1291 NQDLKMKVEMMSEAALNG 1308
Score = 94.7 bits (234), Expect = 5e-19
Identities = 246/1205 (20%), Positives = 454/1205 (37%), Gaps = 206/1205 (17%)
Query: 10 SRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69
S TPS + E RVG RV V G G + ++G T FA G+W G++LDE GKN
Sbjct: 43 SSTPSSE--TQEEFVDDFRVGERVWVNGN-KPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTS--PETPDSSASKVLKREGTDTTAK 127
DG+V G +YF C+ GIF R S++ D + TP S A+ L +
Sbjct: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
Query: 128 TSKLRGLKPKK--APTARKTTTRRP--KPTRPASTGVAGASSS-----------LGPS-- 170
+ P+K P A++ + P T+ AS ++ S + +G
Sbjct: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
Query: 171 -GSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLP-SPSKEEEGLRAQVRDL- 227
G AG + + A+ + P+ + GAV + + GL A V +
Sbjct: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
Query: 228 ----------EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLK 277
+ K +R A A LK L + S + + + +
Sbjct: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKR-SPSASSLSSMSSVASSVSSRPSRTGLLTE 338
Query: 278 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE---------SLQQEVEAL 328
+ + A++ + E + + IE ++++ ERAE ++QE+
Sbjct: 339 TSSRYARK-ISGTTALQEALKEKQQHIEQLLAERDL--ERAEVAKATSHVGEIEQELALA 395
Query: 329 KERVDELTTDLEILKAEIEEKGSDGAASSYQ-LKQLEEQNARLKDALVRMRDLS------ 381
++ D+ +LE ++ + L QLEE+ +++D R+ + S
Sbjct: 396 RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL 455
Query: 382 ----SSEKQEHVKLQKLMEKKNQELEVVRQQRE-------------------RLQEEL-- 416
SEK ++L+K + + QE+ +R++ E LQE+L
Sbjct: 456 EVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 515
Query: 417 --SQAESTIDELKEQVDAALGAEE--------MVEMLTDRNLNLEEKVRELRETVGDLEA 466
+ + I LKE A + E L+ N +L+ K+ + D+ A
Sbjct: 516 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 575
Query: 467 MNEMNDEL-----QENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTI---- 517
+ + E Q+ E ++ + L A E + ++E + DYQ I
Sbjct: 576 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIENLQ 632
Query: 518 -----------KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 566
K+ L A L V +E N EA + + + ++ +T
Sbjct: 633 NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL---VEMEDTLNKL 689
Query: 567 KAIEMELRQMEVAQA--NRHMSLLTAFMPD-----------SFLRPGGDHDCVLVLLLMP 613
+ E++++++EV QA N ++ F LR + L
Sbjct: 690 QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749
Query: 614 RL-----------------ICKAELIRKQAQEK----FELSENCSERPGLRGAAGEQL-- 650
+L KA I ++ Q + L EN SE ++ ++L
Sbjct: 750 QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 809
Query: 651 ---SFAAGLVYSLSL---LQAT---LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
FA ++S+ +Q T LH+ E + S D+ +K+ +M A R D
Sbjct: 810 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL-EKLRENLADMEAKFREKDE 868
Query: 702 LIELL--HKDQLDETV---------NVEPLTKAIKYYQHLYSIHLAEQP-EDCTMQLA-- 747
E L K++L+ + N LTK + L E+ E+ ++L
Sbjct: 869 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND------ELRLKERDVEELQLKLTKA 922
Query: 748 -DHIKFTQSALDCMSV--EVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR 804
++ F Q +++ M+V E + A + +E ++ L DLE C++++ R
Sbjct: 923 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
Query: 805 MPGTDAPGIPAALAFGPQVSDTLLD-------CRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
+ + TLLD R+ + ++ L+E+ A + A
Sbjct: 983 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1042
Query: 858 NEGLLVAALEELAFKASEQIYGTPSS--------SPYECLRQSCNILISTMNKLATAMQE 909
+ + + +E++ + +E + + + + L+++ + +NK +
Sbjct: 1043 EDAMQI--MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV 1100
Query: 910 GEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEA 969
E + ++ AA +++ + +KL + ++ S + EE S
Sbjct: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
Query: 970 NVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAE 1029
N +L ++K+ KDADE +Q + T ALL +K+ E E+ L+ ++ L E
Sbjct: 1161 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK----LRNEVTVLRGE 1216
Query: 1030 KAELK 1034
A K
Sbjct: 1217 NASAK 1221
Score = 80.5 bits (197), Expect = 1e-14
Identities = 93/390 (23%), Positives = 169/390 (43%), Gaps = 61/390 (15%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-KIQLEQVQEWKSKMQEQQADLQ 273
+E++ L ++ DLE+K+ET + E KA+ + K + E++ + +Q+ D +
Sbjct: 953 EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ---NLQKTLLDTE 1009
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMAT----LDKEMAEERAESL-------- 321
+LK AR+E L+ E + + AD A A + A + ++M +E+ E+L
Sbjct: 1010 DKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1068
Query: 322 -----QQEVEALKER----VDELTTDLEIL----------KAEIEEKGSDGAASSYQLKQ 362
Q E++ LKE V+EL E+L + EIE A S QL
Sbjct: 1069 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1128
Query: 363 LEEQNARLKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVR---QQRERLQEE 415
L+E+N +L + L R RD +S E++ V +L+E K +E + ++ +++ LQ+
Sbjct: 1129 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
Query: 416 LS-------QAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMN 468
+S + ++ +++L+ +V G + L LE +L V +LE
Sbjct: 1189 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-- 1246
Query: 469 EMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ-----TIKKYRQL 523
+L+EN R+ A R + +++ + D Q+ +K
Sbjct: 1247 ----QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1302
Query: 524 TAHLQDVNRELTNQQEASVERQQQPPPETF 553
A L +L N E+Q + P F
Sbjct: 1303 EAALNGNGDDLNNYDSDDQEKQSKKKPRLF 1332
Score = 50.4 bits (119), Expect = 1e-05
Identities = 124/695 (17%), Positives = 266/695 (38%), Gaps = 81/695 (11%)
Query: 391 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 450
LQ+ +++K Q +E + +R+ + E+++A S + E+++++ A + L L
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ------HVLEL 406
Query: 451 EEKVRELRETV--GDLEAMNEMNDELQENARETELELREQL------DMAGARVREAQKR 502
E K+ +LR V D E + +N +E + +L+ R + D+ A V E +
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRI 466
Query: 503 VEAAQETVADYQQTIKKYRQLTAHLQ--DVNRELTNQQEASVERQQQPPPETFDFKIKFA 560
+E ++ Q+ + R+L ++ DV+ L+ QE S +++ T D + +
Sbjct: 467 MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT-DHQREIT 525
Query: 561 ETKAHAKAIEMELRQMEVAQ---ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLIC 617
K H A E E Q E+ A +S + ++ V+ L +
Sbjct: 526 SLKEHFGARE-ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIAL--WKSKLE 582
Query: 618 KAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQC 677
A +QA E+ ++S + +G E FA + H E+ +Q
Sbjct: 583 TAIASHQQAMEELKVSFS-------KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 635
Query: 678 SVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAE 737
E +AH + ++ L L K ++ ++E + + + HL E
Sbjct: 636 D-----------SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ---HLVE 681
Query: 738 QPEDCTMQLADHIKFTQ-SALDCMSVEVGRLRAFLQGGQEATDIALLLRD-LETSCSDIR 795
+ IK + L E ++ +AT+ LL D L + S+ +
Sbjct: 682 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741
Query: 796 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL---- 851
KK+R+++ + Q+ ++ + ++ +E+ +L
Sbjct: 742 SEMKKLRQQLEAAEK-----------QIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 790
Query: 852 -----IAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPYECLRQSCNILISTMN 901
++ + E + L+E +ASE+ S + + N+L S +
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKI 961
KL + + E + + L +I + + D + + ++ L++
Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS---GDNSSQLTKMNDELRL 907
Query: 962 KGEELSE-------ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 1014
K ++ E AN S L+K ++ A++ ++ + EE + L +K + E+
Sbjct: 908 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 967
Query: 1015 TMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
M+ +L+A ++ + ++ L+
Sbjct: 968 KMETSHNQCQELKARYERATSETKTKHEEILQNLQ 1002
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 106 bits (265), Expect = 1e-22
Identities = 188/960 (19%), Positives = 389/960 (40%), Gaps = 154/960 (16%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 262
K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K
Sbjct: 912 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971
Query: 263 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
+ E+ A L + + KE K EA ++ ++++ D + + K E+
Sbjct: 972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031
Query: 317 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLKQLE----E 365
+ + L+ +E K+ R+D +L DL++ + I + +D +LK+ E +
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 366 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 425
QN++++D V L K+ ++++L E ELE R R ++++ S ++E
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEE----ELEAERTARAKVEKLRSDLSRELEE 1147
Query: 426 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 484
+ E+++ A GA + +EM R ++ R+L E EA L++ ++ E
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1204
Query: 485 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 544
L EQ+D ++ +K + + D +++ + A+L+ V+R L +Q +
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Query: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 594
++ DF + A+ + + +L + E ++Q R T M D
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE 1324
Query: 595 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 635
+ HDC L+ + R++ KA Q + K+E +
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 636 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 691
E + ++L A V ++ S L+ T HR ++ + VDV ++ +
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1443
Query: 692 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 750
+ +R+ D L E K + ++ +A L+ + A + + +H+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1497
Query: 751 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 809
+ + + E+ L L +GG+ ++ + + LE +++ ++ + +
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557
Query: 810 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 859
+ A L F + + + +++ VV LQ A + + +
Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617
Query: 860 GLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPS 919
+ L E+ + S ++ + ++ ++L T +L A++ + E
Sbjct: 1618 KKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 920 KPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL--- 976
VE R L+AE LE+ V+++ ++S K+ +EL E + R+ LL
Sbjct: 1676 ----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721
Query: 977 -------EKKLDS--------------AAKDADERIEKVQT----------RLEETQALL 1005
+KK++S ++A+E+ +K T + ++T A L
Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781
Query: 1006 RKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTIEGLRG 1050
+ +K E+T+ LQ +D+ LEA EL+ L ++ KR E ++G
Sbjct: 1782 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKG 1841
Score = 77.8 bits (190), Expect = 6e-14
Identities = 163/845 (19%), Positives = 342/845 (40%), Gaps = 103/845 (12%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKSKMQEQQADL 272
KE ++ + ++E LE +R E + K+ L EK+ +QL+ E Q+ D
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-----QDNLNDA 903
Query: 273 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 332
+ R + K K LEAK + M E + + + K+ L+ E LK+ +
Sbjct: 904 EERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLEDECSELKKDI 956
Query: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 392
D DLE+ A++E++ A+ ++K L E+ A L + + ++ + EK +
Sbjct: 957 D----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TKEK------K 999
Query: 393 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLE 451
L E Q L+ ++ + +++ LS+++ +++ + ++ +L E+ V M +R LE
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV-NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058
Query: 452 EKVRELRETVGDLEAMNEMNDELQ--ENARETELELREQ---LDMAGARVREAQKRVEAA 506
++ +E++ DLE ND+LQ E ++ E ++ +Q ++ + QK+++
Sbjct: 1059 GDLKLTQESIMDLE-----NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113
Query: 507 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 566
Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++ K
Sbjct: 1114 QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEMNKKRE 1170
Query: 567 KAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 624
+ R +E A Q + L DS G D + + K +L ++
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQKLEKE 1222
Query: 625 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 684
+++ K EL + S + A + L + + L + +L+ + K
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAK 1281
Query: 685 VGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTM 744
+ + E++ + LI L + +L T +E L + + E+
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL------------EEEGKAKN 1329
Query: 745 QLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR 804
LA ++ + D + Q +E A L R L + S++ Q+ K
Sbjct: 1330 ALAHALQSARHDCDLLRE---------QYEEETEAKAELQRVLSKANSEVAQWRTKYE-- 1378
Query: 805 MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA 864
TDA Q ++ L + +K L + +E A + L + + L
Sbjct: 1379 ---TDA----------IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425
Query: 865 ALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 924
+E+L +++ + R IL K + E E + S +
Sbjct: 1426 EIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Query: 925 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA 984
A + E + ++ + I +L + L G+ + E L + K+L+
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE----LEKVRKQLEVEK 1539
Query: 985 KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRT 1044
+ +E+ + LE + + + + EF + ++A+I++ AEK E ++ +R
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 1045 IEGLR 1049
++ L+
Sbjct: 1596 VDSLQ 1600
Score = 74.3 bits (181), Expect = 7e-13
Identities = 178/884 (20%), Positives = 366/884 (41%), Gaps = 134/884 (15%)
Query: 212 SPSKEEEGLRAQVRDLEEKLET-----LRLKRAEDKAK---------LKELEKHKIQLEQ 257
S SK + L QV DLE LE + L+RA+ K + + +LE K+QLE+
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 258 --------VQEWKSKMQEQQA---DLQRRLKEAR---KEAKEALEAKER----------- 292
+ + SK++++Q LQ++LKE + +E +E LEA+
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 293 YMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSD 352
E+ + ++ +E A + E + + E + ++ ++E T E A + +K +D
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 353 GAASSYQ----LKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE-VVRQ 407
A + L++++++ + K D +S ++ +K + +EK ++ LE +
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260
Query: 408 QRERLQE----------ELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVREL 457
R +L+E + ++ ++ EL Q++ E ++ LT L+ +++ +L
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK---EALISQLTRGKLSYTQQMEDL 1317
Query: 458 -RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQT 516
R+ + +A N + LQ + +L LREQ + E Q+ + A VA ++
Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKANSEVAQWRT- 1375
Query: 517 IKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 572
KY Q T L++ ++L + + + E E + K E H E+E
Sbjct: 1376 --KYETDAIQRTEELEEAKKKLAQRLQDAEEAV-----EAVNAKCSSLEKTKHRLQNEIE 1428
Query: 573 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFEL 632
++V ++N + L + + D +L AE +K + + EL
Sbjct: 1429 DLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWKQKYEESQSEL 1469
Query: 633 SENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEM 692
+ E R + E SL L+ T R L + D+ +++G E
Sbjct: 1470 ESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLTEQLG----EG 1521
Query: 693 SAHERSLDFLIELLHKDQLDETVNVEP------------LTKAIKYYQHLYSIH--LAEQ 738
+ L+ + + L ++L+ +E L +++ Q I LAE+
Sbjct: 1522 GKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581
Query: 739 PEDCTMQLADH---IKFTQSALDCMSV---EVGRLRAFLQGGQEATDIALLLRDLETSCS 792
E+ +H + Q++LD + EV R++ ++G + ++ + L +
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEIQLSHANRMAA 1639
Query: 793 DIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL- 851
+ ++ K ++ + T + A+ + + + + + A L+E+ A Q
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1698
Query: 852 -IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 910
LAE E L+ E + Q+ + ++S ++ + L +++ A+QE
Sbjct: 1699 RSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 911 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 970
E+ + A L+ E + L ++ E IK+L+ L + E+++
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-EAEQIALKG 1809
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 1014
+ L +KL++ ++ + +E Q R E+ +RK E+ +E
Sbjct: 1810 GKKQL--QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Score = 63.9 bits (154), Expect = 9e-10
Identities = 65/310 (20%), Positives = 132/310 (42%), Gaps = 58/310 (18%)
Query: 232 ETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE 291
E LR+K+ + +L + +IQL ++ Q+Q LQ LK+ + + +A+ A +
Sbjct: 1612 EVLRVKKKMEG----DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 292 RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS 351
E +A + E R LQ E+E L+ V++ ++ + E+ E
Sbjct: 1668 DLKENIA--------------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE--- 1710
Query: 352 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER 411
+S +++ L QN L + +K+ L +L + + ++ R E+
Sbjct: 1711 ----TSERVQLLHSQNT----------SLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 412 LQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE--------------- 456
++ ++ A +ELK++ D + E M + + +L+ ++ E
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 457 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
+RE G+LEA + N E + R++E ++E + E +K + Q+ V
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDKKNLLRLQDLVDK 1872
Query: 513 YQQTIKKYRQ 522
Q +K Y++
Sbjct: 1873 LQLKVKAYKR 1882
Score = 57.8 bits (138), Expect = 7e-08
Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 49/276 (17%)
Query: 227 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 275
L+ +LE LR +++ E KL E E ++QL Q K KM+ LQ
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1802
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
+I KG KQL++ AR+++ + +E++ + + K M
Sbjct: 1803 E--------QIALKGGK--------KQLQKLEARVRE----LEGELEAEQKRNAESVKGM 1842
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN------ 449
K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902
Query: 450 ------------LEEKVRELRETVGDLEAMNEMNDE 473
E +V +LR D+ A +M+DE
Sbjct: 1903 HELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDE 1938
Score = 34.7 bits (78), Expect = 0.60
Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 5/172 (2%)
Query: 868 ELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELR 927
+L FK + + +++ + T+ K +E E + ++L+
Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892
Query: 928 AAALRAEITDAEGLGLKLEDR----ETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 983
A + + DAE +L E +KE+ + L+ + E +E + LE +
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 984 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
KD D+ +E ++E+ + K K E M L I +L EK L++
Sbjct: 953 KKDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 103 bits (258), Expect = 8e-22
Identities = 145/598 (24%), Positives = 251/598 (41%), Gaps = 70/598 (11%)
Query: 14 SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69
SGS +S S + LR+G RV ++G G V YVG T FA G+W GV LDE GKN
Sbjct: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260
Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129
DG V G +YF C G+F +V G +TSP + +K KR +A T
Sbjct: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP-----AKAKKTKRMAMGVSALTH 313
Query: 130 KLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTP 186
P + + ++ RP+ +G+ +SS SG+ + E +
Sbjct: 314 -----SPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHI 368
Query: 187 AQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQ----VRDLEEKLETLRLKRAEDK 242
Q + V A + KE L+AQ V + EEKL+ RL
Sbjct: 369 EQLLAERDLERAEVAK---ATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARL------ 419
Query: 243 AKLKELEKHKIQL-EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTA 301
++ + K K+ L Q++E + K++ DLQ R++E K LE + + E A
Sbjct: 420 -LVESVRKEKVDLSNQLEEERRKVE----DLQFRVEE-ESITKGDLETQTQL--EHARIG 471
Query: 302 DAIEMATLDKEMAEERAESLQQE---VEALKERVDELTTDLEILKAEIEE---------- 348
+ + L+K AE L A K RV +L +L + + EIEE
Sbjct: 472 ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
Query: 349 --KGSDGAASSYQLKQ--LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV 404
AA +L++ L +++ V + K ++ KL + +
Sbjct: 532 PPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQE 591
Query: 405 VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL 464
V ++++Q+ S+ +D K ++D+ A + + L D L ++ +G+L
Sbjct: 592 VAGLKDKVQQATSENMGLMDNWKSKLDSL--ASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
Query: 465 EAMNEMNDELQENARETELELREQLDMA-GARVREA-QKRVEAAQETVADYQQTIKKYRQ 522
+A+ E +++ L+ + L+ A + +EA +++++ AQE +A Q+ + +
Sbjct: 650 KAVME-GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLE 708
Query: 523 LTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 580
+ A + + Q E + + + E + A+AIE Q+ +A+
Sbjct: 709 VQASQHRLELQEAQDQRRDAELR------VHELEKLDVEYRGQAQAIEFLKEQISLAE 760
Score = 89.0 bits (219), Expect = 3e-17
Identities = 138/599 (23%), Positives = 233/599 (38%), Gaps = 100/599 (16%)
Query: 4 SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49
S H S PS S +A A +P VG RV V G G V Y+G
Sbjct: 42 SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100
Query: 50 TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107
T FA G+W GV+LD+ GKNDG V G +YF C GIF R S++ Q +G+ + +
Sbjct: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160
Query: 108 TPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSL 167
+A + GT T TS++ L+ ++ KT + S+L
Sbjct: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNE--------------SGSNL 206
Query: 168 GPSGSASAGE----LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQ 223
SGS GE L +T + + T L P + +G A
Sbjct: 207 SDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAG 266
Query: 224 VRDLE---------EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
R + + +R+ + AK K+ ++ + + + S
Sbjct: 267 TRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSV 326
Query: 274 RRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVE 326
R L E RY +++ T A++ A +K+ +AE E + EV
Sbjct: 327 ASSVGGRPSRSGLLTETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVA 383
Query: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLK---------------QLEEQNARLK 371
+ E+ ++ +LKA+ E+ ++ + + QLEE+ +++
Sbjct: 384 KATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVE 443
Query: 372 DALVRMR-------DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
D R+ DL + + EH ++ +L Q L + + Q ERL EL+ T
Sbjct: 444 DLQFRVEEESITKGDLETQTQLEHARIGEL----EQSLLLEKAQAERLLRELADNRLTTV 499
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET------VGDLEAMNEMNDELQENA 478
K +V ++ E LT R +EE + L + D + + + L +
Sbjct: 500 AEKSRV------LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSAS 553
Query: 479 RETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 537
+E + E +G + +K ++A Q V + +KY Q A L+D ++ T++
Sbjct: 554 KEHQRE-------SGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSE 605
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%)
Query: 218 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
E L+ Q+ E+K L+ RL+RAE + K +E+E + +L + ++ + +
Sbjct: 750 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 808
Query: 277 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
E+ ++E + KE +++ + T EM + +L+ + ++ +++VD
Sbjct: 809 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 868
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
L + L+AE+E +S QL + ++ R + +L +R L
Sbjct: 869 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 915
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
L+E R L E+ +AE I E K + D E++ + +++L+
Sbjct: 916 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 967
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
+ R ++ D + E+ LQ TE LR+ LD A ++ +K +E A + D
Sbjct: 968 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 1020
Query: 514 QQTI 517
QTI
Sbjct: 1021 AQTI 1024
>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
[Homo sapiens]
Length = 1011
Score = 103 bits (258), Expect = 8e-22
Identities = 148/599 (24%), Positives = 249/599 (41%), Gaps = 94/599 (15%)
Query: 14 SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69
SGS +S S + LR+G RV ++G G V YVG T FA G+W GV LDE GKN
Sbjct: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260
Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129
DG V G +YF C G+F +V G +TSP + +K KR +A T
Sbjct: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP-----AKAKKTKRMAMGVSALTH 313
Query: 130 KLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTP 186
P + + ++ RP+ +G+ +SS SG+ + E +
Sbjct: 314 -----SPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHI 368
Query: 187 AQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQ----VRDLEEKLETLRL------ 236
Q + V A + KE L+AQ V + EEKL+ RL
Sbjct: 369 EQLLAERDLERAEVAK---ATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
Query: 237 --------KRAEDKAKLKELE---------KHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
+ E++ K+++L+ K ++L V E KS++ + + +L R E
Sbjct: 426 KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAE-KSRVLQLEEELTLRRGEI 484
Query: 280 RK----------------EAKEALEAKER-------YMEEMADTADAIEMA--TLDKEMA 314
+ +A E L +ER + E D E A E+
Sbjct: 485 EELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 544
Query: 315 EERA--ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKD 372
+ RA E QEV LK++V + T++ L + K D AS +Q K LE+ A L
Sbjct: 545 KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK-LDSLASDHQ-KSLEDLKATLNS 602
Query: 373 A-------LVRMRDLSSSEKQEH-VKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
+ ++ + K EH ++L L K + E + +++E L+E+L +A+ +
Sbjct: 603 GPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELA 662
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 484
L+ A L + + L L+E + R+ + + +++ E + A+ E
Sbjct: 663 GLQRHWRAQLEVQ-----ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEF- 716
Query: 485 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 543
L+EQ+ +A ++ + ++ A + + + +K LQ V ++Q +E
Sbjct: 717 LKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIE 775
Score = 83.6 bits (205), Expect = 1e-15
Identities = 131/577 (22%), Positives = 228/577 (39%), Gaps = 91/577 (15%)
Query: 4 SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49
S H S PS S +A A +P VG RV V G G V Y+G
Sbjct: 42 SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100
Query: 50 TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107
T FA G+W GV+LD+ GKNDG V G +YF C GIF R S++ Q +G+ + +
Sbjct: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160
Query: 108 TPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSL 167
+A + GT T TS++ L+ ++ KT + S+L
Sbjct: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNE--------------SGSNL 206
Query: 168 GPSGSASAGE----LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQ 223
SGS GE L +T + + T L P + +G A
Sbjct: 207 SDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAG 266
Query: 224 VRDLE---------EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
R + + +R+ + AK K+ ++ + + + S
Sbjct: 267 TRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSV 326
Query: 274 RRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVE 326
R L E RY +++ T A++ A +K+ +AE E + EV
Sbjct: 327 ASSVGGRPSRSGLLTETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVA 383
Query: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386
+ E+ ++ +LKA Q E+ A ++ L R R L S ++
Sbjct: 384 KATSHICEVEKEIALLKA-----------------QHEQYVAEAEEKLQRARLLVESVRK 426
Query: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 446
E V L +E++ +++E ++ + E +E +++ + + + E+ ++ E LT R
Sbjct: 427 EKVDLSNQLEEERRKVEDLQFRVE--EESITKGDLELTTVAEKSRVL----QLEEELTLR 480
Query: 447 NLNLEEKVRELRET------VGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQ 500
+EE + L + D + + + L ++E + E +G + +
Sbjct: 481 RGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE-------SGVLRDKYE 533
Query: 501 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 537
K ++A Q V + +KY Q A L+D ++ T++
Sbjct: 534 KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSE 570
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%)
Query: 218 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
E L+ Q+ E+K L+ RL+RAE + K +E+E + +L + ++ + +
Sbjct: 715 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 773
Query: 277 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
E+ ++E + KE +++ + T EM + +L+ + ++ +++VD
Sbjct: 774 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 833
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
L + L+AE+E +S QL + ++ R + +L +R L
Sbjct: 834 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 880
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
L+E R L E+ +AE I E K + D E++ + +++L+
Sbjct: 881 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 932
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
+ R ++ D + E+ LQ TE LR+ LD A ++ +K +E A + D
Sbjct: 933 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 985
Query: 514 QQTI 517
QTI
Sbjct: 986 AQTI 989
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 99.4 bits (246), Expect = 2e-20
Identities = 190/965 (19%), Positives = 388/965 (40%), Gaps = 164/965 (16%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 262
K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKH 969
Query: 263 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
+ E+ A L + + KE K EA ++ ++++ D + T K E+
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 317 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLK----QLEE 365
+ + L+ +E K+ R+D +L DL++ + I + +D +LK +L
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 366 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 425
NAR++D + L S +++ +LQ +E+ +ELE R R ++++ S ++E
Sbjct: 1090 LNARIEDE----QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Query: 426 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 484
+ E+++ A GA + +EM R ++ R+L E EA L++ ++ E
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1202
Query: 485 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 544
L EQ+D ++ +K + + D +++ + A+L+ + R L +Q +
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262
Query: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 594
++ D + A+ + + +L + E ++Q R T + D
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 595 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 635
+ HDC L+ + R++ KA Q + K+E +
Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382
Query: 636 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 691
E + ++L A V ++ S L+ T HR ++ + VDV ++ +
Sbjct: 1383 TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1441
Query: 692 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 750
+ +R+ D L E K + ++ +A L+ + A + + +H+
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1495
Query: 751 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 809
+ + + E+ L L G+ ++ + + LE +++ ++ + +
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 810 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 859
+ A L F + + + +++ VV LQ A + + NE
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR-----SRNE 1610
Query: 860 GLLVAA-----LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
L V L E+ + S ++ + ++ ++L T +L A++ +
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E VE R L+AE LE+ V+++ ++S K+ +EL E + R+
Sbjct: 1669 ENIAI----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Query: 975 LL----------EKKLDS--------------AAKDADERIEKVQT----------RLEE 1000
LL +KK+D+ ++A+E+ +K T + ++
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774
Query: 1001 TQALLRKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTI 1045
T A L + +K E+T+ LQ +D+ LEA EL+ L ++ KR
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 1046 EGLRG 1050
E ++G
Sbjct: 1835 ESVKG 1839
Score = 86.7 bits (213), Expect = 1e-16
Identities = 177/854 (20%), Positives = 346/854 (40%), Gaps = 105/854 (12%)
Query: 208 PPLPSPSKEEE--GLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKS 263
P L S +E+E ++ + L+E LE +R E + K+ L EK+ +QL+ E
Sbjct: 838 PLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--- 894
Query: 264 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 323
Q+ AD + R + K K LEAK + M E + + + K+ L+
Sbjct: 895 --QDNLADAEERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLED 945
Query: 324 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 383
E LK +D DLE+ A++E++ A+ ++K L E+ A L + + ++ +
Sbjct: 946 ECSELKRDID----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TK 994
Query: 384 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 443
EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ V M
Sbjct: 995 EK------KALQEAHQQALDDLQAEEDKV-NTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 444 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARVREAQK 501
+R LE ++ +E++ DLE + DE + ++ EL L +++ A + QK
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDE-RLKKKDFELNALNARIEDEQALGSQLQK 1106
Query: 502 RVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAE 561
+++ Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEM 1163
Query: 562 TKAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKA 619
K + R +E A Q + L DS G D + + K
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQ 1215
Query: 620 ELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSV 679
+L +++++ K EL + S + A L Q HR + +Q SV
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----QMNEHRSKAEETQRSV 1270
Query: 680 -DVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ + L E R LD ++ + LT+ Y +Q
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLD-----------EKEALISQLTRGKLTY--------TQQ 1311
Query: 739 PEDCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR 795
ED QL + +K + AL + LR Q +E A L R L + S++
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE--QYEEETEAKAELQRVLSKANSEVA 1369
Query: 796 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 855
Q+ K TDA Q ++ L + +K L + +E A + L
Sbjct: 1370 QWRTKYE-----TDA----------IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Query: 856 AENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAE 915
+ + L +E+L +++ + R IL K + E E +
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 916 RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL 975
S + A + E + ++ + I +L + L G+ + E L
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE----LEK 1528
Query: 976 LEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
+ K+L++ + +E+ + LE + + + + EF + ++A+I++ AEK E +
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEME 1584
Query: 1036 RLNSQSKRTIEGLR 1049
+ R ++ L+
Sbjct: 1585 QAKRNHLRVVDSLQ 1598
Score = 80.5 bits (197), Expect = 1e-14
Identities = 166/832 (19%), Positives = 334/832 (40%), Gaps = 101/832 (12%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E L A++ D + L+ K E +A+++ELE+ +LE + ++K+++ ++DL R
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEE---ELEAERTARAKVEKLRSDLSRE 1142
Query: 276 LKEARKEAKEA-------LEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEVEA 327
L+E + +EA +E ++ E +E ATL E A + V
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
L E++D +L+ +K ++E++ S+ + EQ + K L +M + E
Sbjct: 1203 LGEQID----NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258
Query: 388 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
H + E+ + + + QR +LQ E + +DE E ++ LT
Sbjct: 1259 H---RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE----------KEALISQLTRGK 1305
Query: 448 LNLEEKVREL-RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 506
L +++ +L R+ +++A N + LQ + +L LREQ + E Q+ + A
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKA 1364
Query: 507 QETVADYQQTIKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 562
VA ++ KY Q T L++ ++L + + + E E + K E
Sbjct: 1365 NSEVAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAV-----EAVNAKCSSLEK 1416
Query: 563 KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELI 622
H E+E ++V ++N + L + + D +L AE
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWK 1457
Query: 623 RKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY 682
+K + + EL + E R + E SL L+ T R L + D+
Sbjct: 1458 QKYEESQSELESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLT 1513
Query: 683 KKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 732
+++GS + ++ A + L +E E + L +++ Q
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAE 1571
Query: 733 IH--LAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRAFLQGGQEATDIALLL 784
I LAE+ E+ +H++ S + E R++ ++G + ++ + L
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG--DLNEMEIQL 1629
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
++ ++ K ++ + T + A+ + + + + + A L+E+
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 845 AAAAAQL--IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNK 902
A Q LAE E L+ E + Q+ + ++S ++ L +
Sbjct: 1689 RAVVEQTERSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMDADLSQLQTE 1740
Query: 903 LATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIK 962
+ A+QE E+ + A L+ E + L ++ E IK+L+ L +
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-E 1799
Query: 963 GEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 1014
E+++ + L +KL++ ++ + +E Q R E+ +RK E+ +E
Sbjct: 1800 AEQIALKGGKKQL--QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Score = 65.5 bits (158), Expect = 3e-10
Identities = 85/429 (19%), Positives = 188/429 (43%), Gaps = 71/429 (16%)
Query: 218 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQRRL 276
E + + ++L+E++ L + + ELEK + QLE + E +S ++E +A L+
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERV--- 332
+ + E + K ++A+ + +E A + + + SL E + E +
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL--SSSEKQEHVK 390
++ DL ++ ++ A + Q+K L+ + LKD +++ D ++ + +E++
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLLKDTQIQLDDAVRANDDLKENIA 1672
Query: 391 L----QKLMEKKNQELEVVRQQRER--------------------------------LQE 414
+ L++ + +EL V +Q ER +
Sbjct: 1673 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732
Query: 415 ELSQAESTIDELKEQ------------VDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 462
+LSQ ++ ++E ++ DAA+ AEE+ + D + +LE + + +T+
Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIK 1791
Query: 463 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ----ETVADYQQTIK 518
DL+ DE ++ A + ++QL ARVRE + +EA Q E+V +++ +
Sbjct: 1792 DLQ---HRLDEAEQIALKGG---KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 519 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 578
+ ++LT ++ + L Q+ + + Q + + + + AE +A+ + Q E+
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQD--LVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Query: 579 AQANRHMSL 587
+A +
Sbjct: 1904 DEAEERADI 1912
Score = 57.0 bits (136), Expect = 1e-07
Identities = 61/266 (22%), Positives = 122/266 (45%), Gaps = 32/266 (12%)
Query: 227 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 275
L+ +LE LR +++ E KL E E ++QL Q K KM + LQ
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
+I KG KQL++ AR+++ + + +E++ + + K M
Sbjct: 1801 E--------QIALKGGK--------KQLQKLEARVRE----LENELEAEQKRNAESVKGM 1840
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+ KV+
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1900
Query: 456 -ELRETVGDLEAMNEMNDELQENARE 480
EL E + ++L+ +R+
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRD 1926
Score = 50.4 bits (119), Expect = 1e-05
Identities = 128/633 (20%), Positives = 250/633 (39%), Gaps = 76/633 (12%)
Query: 430 VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 489
+D+ GAE+++ L + + ++ G L + EM DE R + + R Q
Sbjct: 736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE-----RLSRIITRIQA 790
Query: 490 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 549
G R K++ ++++ Q I+ + + S ER+++
Sbjct: 791 QSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMA 850
Query: 550 PETFDF-KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLV 608
+F ++K A K+ A+ E+E + + + Q + L D+ + C +
Sbjct: 851 SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQL 908
Query: 609 LLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLH 668
+ +L K + + ++ +++ E++ +E + ++ S + L L A +
Sbjct: 909 IKNKIQLEAKVKEMNERLEDEEEMN---AELTAKKRKLEDECSELKRDIDDLELTLAKVE 965
Query: 669 RYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFL------IELLHKDQLD----ETVNVE 718
+ +HA KV +L EM+ + + L ++ H+ LD E V
Sbjct: 966 KEKHATEN-------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018
Query: 719 PLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEAT 778
LTKA + L +Q +D L K + +++ R + L+G + T
Sbjct: 1019 TLTKA--------KVKLEQQVDDLEGSLEQEKK--------VRMDLERAKRKLEGDLKLT 1062
Query: 779 DIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVV 838
+++ DLE + + KK + +A I A G Q+ L K L +
Sbjct: 1063 QESIM--DLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKL----KELQARI 1115
Query: 839 AVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIS 898
L+E A A + + L LEE++ + E T ++ I
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT-------------SVQIE 1162
Query: 899 TMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEG-LGLKLEDRETVIKELKK 957
K Q+ D E + E AAALR + D+ LG ++++ + V ++L+K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219
Query: 958 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 1017
E SE + L + ++ K A +EK+ LE+ R K +E + +++
Sbjct: 1220 -------EKSEFKLELDDVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 1018 ALQADIDQLEAEKAELKQRLNSQSKRTIEGLRG 1050
L + +L+ E EL ++L+ + + RG
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/133 (25%), Positives = 67/133 (50%), Gaps = 13/133 (9%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKM 265
L K+ + L A+VR+LE +LE + + AE +++ E+ Q E+ ++ ++
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 266 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQE 324
Q+ LQ ++K +++A+EA EE A+T + + AEERA+ + +
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEA--------EEQANTNLSKFRKVQHELDEAEERADIAESQ 1916
Query: 325 VEALKERVDELTT 337
V L+ + ++ T
Sbjct: 1917 VNKLRAKSRDIGT 1929
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 99.0 bits (245), Expect = 3e-20
Identities = 246/1088 (22%), Positives = 426/1088 (39%), Gaps = 149/1088 (13%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLK----RAEDKAKLKELEKHKIQLEQ----VQEW 261
L ++ E R+ +E+LE LRL+ R + L+ E+ + LEQ ++
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 262 KSKMQEQQADLQRRL-------KEARKEAKEALEAKERYMEEMADTAD-----AIEMATL 309
+S++QEQ A L R+L ++AR+EA+ +EA ER E A A+++
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888
Query: 310 DKE--MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQN 367
++E E A L+ E EAL+ + E+ L L+A E+ ++G A + L +
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
Query: 368 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR-------ERLQEELSQAE 420
A L+ ++ ++ +S +K+ + QKL++ + + +R+QR +RLQ E A
Sbjct: 949 AGLRQQIIATQEKASLDKE--LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW 1006
Query: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480
++ + Q+ + L E+ E+L LE + EL E + L+ + L E+ ++
Sbjct: 1007 RELEAERAQLQSQLQREQE-ELLA----RLEAEKEELSEEIAALQQERDEGLLLAESEKQ 1061
Query: 481 TELELREQLDMA------GAR-------------VREAQKRVEAAQETVADYQQTIKKYR 521
L L+E A G R R+AQ R E + TV
Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV----------N 1111
Query: 522 QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQA 581
LT+ L+D+ + A + ++ + D + A+ + +LR +E A+
Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171
Query: 582 NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERP 640
LL A + G E+ R++A E + L E ER
Sbjct: 1172 GLRRELLEAQRKLRESQEG------------------REVQRQEAGELRRSLGEGAKERE 1213
Query: 641 GLRGAAGEQLSF---AAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHER 697
LR + E S A SL L + L + V K+ G L + ER
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 698 S-LDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDC----TMQLADHIKF 752
S L+ EL + + ++ E + + + L E+ E T+ L +
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
Query: 753 TQSALDCM--SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDA 810
+++L+ M ++V + + Q G+ T LL LE + +Q R G +
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR----GLEL 1389
Query: 811 PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELA 870
+ AA A ++ L + A E+A Q A A+ GL A L
Sbjct: 1390 K-LEAARAEAAELGLRLSAAEGRAQGLEA---ELARVEVQRRAAEAQLGGLRSALRRGLG 1445
Query: 871 F-----KASEQIYGTPS-SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 924
A + G+P+ +P E + N ST+ + A P S
Sbjct: 1446 LGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP-STLECSPGSQPPSPGPATSPASPDLDP 1504
Query: 925 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---D 981
E ALR + + + ++ T L + L E A R L+K + +
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 982 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD-------ALQADIDQLEAEKAELK 1034
A + D R+ VQ L + +R+ E+E T+D +LQA +L A + ++
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624
Query: 1035 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 1094
+ +++K +EG + + S E QR ++ G+ S G + D
Sbjct: 1625 KMKANETK--LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG---LSDRE--- 1676
Query: 1095 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1154
Q A++ + LQ + + +++KA L V +L+ E GAL K
Sbjct: 1677 AQAQALQDRVDSLQRQ---VADSEVKAGTLQLT---VERLNGALAKVEESEGALRDKVRG 1730
Query: 1155 LLETLNQL-----STHTHVVDITRTSPAAKSPSAQLMEQV-----------AQLKSLSDT 1198
L E L Q ST + + + A + L E++ Q SL +
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790
Query: 1199 VEKLKDEV 1206
V+ L+ EV
Sbjct: 1791 VQTLRGEV 1798
Score = 97.1 bits (240), Expect = 1e-19
Identities = 221/1019 (21%), Positives = 393/1019 (38%), Gaps = 113/1019 (11%)
Query: 91 QSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAK----TSKLRGLKPKKAPTARKTT 146
Q Q+Q D AD ++ T A K L+++ + T KL L+ +
Sbjct: 383 QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
Query: 147 TRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVL-TSPG 205
T + + +A A S SG +G +++ S + L+ P+P +SPG
Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
Query: 206 ---AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 262
+ PSP+ + A + L ++ + + E + L +++
Sbjct: 503 RGRSPRRGPSPACSDSSTLALIHS------ALHKRQLQVQDMRGRYEASQDLLGTLRKQL 556
Query: 263 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDK-------EMAE 315
S + ++ L+ +L+ R + A++A E E+ A E+ + +K ++A+
Sbjct: 557 SDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQ 616
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGA-------ASSYQLKQLEEQNA 368
++AE L+QE E L+ +EL + L+ E E+ DGA S QL+QLE + +
Sbjct: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
Query: 369 RLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE 428
L LV +R+ S + LQ EK + + + R++ ELS + +E
Sbjct: 677 VLAKELVEVREALSRATLQRDMLQ--AEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
Query: 429 QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETE---LEL 485
Q D+ + E L L+L V +L E L+ ++ ARE + EL
Sbjct: 735 Q-DSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEEL 793
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR-QLTAHLQDVNRELTNQQEASVER 544
R + ++A + + + E AQE + T++ R QL L ++R+L+ +++ +
Sbjct: 794 RLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQA 853
Query: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 604
++ E + +A+E R+ E A A H L + R G
Sbjct: 854 RR--------------EAQRQVEALERAAREKE-ALAKEHAGLAVQLVAAE--REGRTLS 896
Query: 605 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFA--------AGL 656
L + + + L Q Q L++ + R L A G+ L A AGL
Sbjct: 897 EEATRLRLEKEALEGSLFEVQRQ----LAQLEARREQLE-AEGQALLLAKETLTGELAGL 951
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKV-GSLYPEMSAHERSLDFLIELLHKDQLDETV 715
+ Q + ++Q V ++ SL + +AHE L L +
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 716 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALD--CMSVEVGRLRAFLQG 773
L ++ Q L + E +L++ I Q D + E + +A
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKE----ELSEEIAALQQERDEGLLLAESEKQQALSLK 1067
Query: 774 GQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKH 833
E T ++ L S + I ++ +R A + Q T+
Sbjct: 1068 ESEKTALSEKLMGTRHSLATISLEMERQKR-----------DAQSRQEQDRSTVNALTSE 1116
Query: 834 LTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC 893
L + A +E AAA AQ + L E L + +A E LR
Sbjct: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEE-------------LRTQL 1163
Query: 894 NILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRE 949
+L + L + E + A LR + + E L E+
Sbjct: 1164 RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELR 1223
Query: 950 TVIKELKK---SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLR 1006
+ +K+ + SLK+ E+ + +L+LLE+ + K+A E +Q +E ++ R
Sbjct: 1224 SAVKKAESERISLKLANEDKEQ---KLALLEEARTAVGKEAGELRTGLQ-EVERSRLEAR 1279
Query: 1007 KKEKEFEETMDALQADIDQLEAEKAELKQRL------NSQSKRTIEGLRGPPPSGIATL 1059
++ +E M L ++ +L E AEL+ RL +S+R GLR G A+L
Sbjct: 1280 RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Score = 78.6 bits (192), Expect = 4e-14
Identities = 191/926 (20%), Positives = 351/926 (37%), Gaps = 122/926 (13%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
+E E LR Q+R LE+ + LR + E + KL+E QE + +++ +L+R
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRES----------QEGREVQRQEAGELRR 1203
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES----LQQEVEALKE 330
L E KE EA R EE+ E + ++A E E L++ A+ +
Sbjct: 1204 SLGEGAKER----EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
Query: 331 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD-------LSSS 383
EL T L+ ++ E + Q+K L+ +N RL L ++
Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
Query: 384 EKQEHVKLQKLMEKKNQELEVVRQQ----RERLQEELSQAESTIDELKEQVDAALGAE-E 438
++E + L++ + K LEV+RQ+ + +LQE+ + + L ++ A G E +
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
++ L LE E E L A L+ E++ R G +R
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRS 1438
Query: 499 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP---PETFDF 555
A +R + + + A + L + QPP P T
Sbjct: 1439 ALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP- 1497
Query: 556 KIKFAETKAHAKAIEMELRQ--MEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMP 613
A +A+ LR+ E+ A R L +
Sbjct: 1498 ----ASPDLDPEAVRGALREFLQELRSAQRERDELRT-----------------QTSALN 1536
Query: 614 RLICKAELIRKQAQEKF-ELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEH 672
R + + E R A + +L + +E R + +LS G+ L+L + ++ R E
Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEESVRRSER 1593
Query: 673 ALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 732
+ ++D +V +L + A E L E + K + +ET +E + +K
Sbjct: 1594 E-RRATLD---QVATLERSLQATESELRASQEKISKMKANET-KLEGDKRRLK------- 1641
Query: 733 IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLLRDLETSC 791
+ + E T++L + + L + + A Q Q+ D + + D E
Sbjct: 1642 -EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700
Query: 792 SDIRQFCKKIRRRMPGTD---------APGIPAALAFGPQVSDTLLDCRKHLTWVVA--- 839
++ +++ + + G+ ALA ++ D HL +
Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACE 1760
Query: 840 ----VLQEVAAAAAQLIAPLAENEGLL----------VAALEELAFKASEQIYGTPSSSP 885
VLQE AA Q ++ + L VA LE +A Q+
Sbjct: 1761 HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL-----QQL 1815
Query: 886 YECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKL 945
E LRQ + +N + E ER S ++ A L AE + E L+L
Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGS----LQRALAQLEAEKREVERSALRL 1871
Query: 946 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA-- 1003
E ++ ++ + E VRLS + +LD A+ + + Q ++++ +A
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931
Query: 1004 -LLRKKEKEFEETMDA------LQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI 1056
+L + + +DA LQ ++++L + +A+ ++ L ++ + + +RG +
Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-V 1990
Query: 1057 ATLVSGIAGEEQQRGAIPGQAPGSVP 1082
+TL G +E +R + P P P
Sbjct: 1991 STL-KGQLQQELRRSSAPFSPPSGPP 2015
Score = 70.1 bits (170), Expect = 1e-11
Identities = 109/526 (20%), Positives = 216/526 (41%), Gaps = 94/526 (17%)
Query: 132 RGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPST-PAQTP 190
RGL +AP+ RP P PA A S S S S PS PA +P
Sbjct: 1442 RGLGLGRAPSPAP----RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
Query: 191 LAAPIIPTPVLTSPGA-VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE 249
+ + P V + + L S +E + LR Q L +L + +R ++ ++L+
Sbjct: 1498 ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ 1557
Query: 250 KHKIQLEQ-----------------VQEWKSKMQEQQ--------ADLQRRLKEARKEAK 284
K + E+ +QE + E++ A L+R L+ E +
Sbjct: 1558 KAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELR 1617
Query: 285 EA-------------LEAKERYMEEMADTADA------IEMATLDKEMAEER-------- 317
+ LE +R ++E+ D +++ ++ +L+ E+ R
Sbjct: 1618 ASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1677
Query: 318 -AESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 376
A++LQ V++L+ +V + L+ +E A L ++ L +AL +
Sbjct: 1678 QAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQ 1737
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+S + +++ LQK + + +V++++ + ++ LS+A L EQV G
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGE 1797
Query: 437 EEMVEMLTDRNLNLEEKVRELRETV-----GDLEAMN---EMNDE----------LQENA 478
+E+ + + E ++++LRE + G+ A+N ++ DE LQ
Sbjct: 1798 VADLEL---QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRAL 1854
Query: 479 RETELELRE------QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNR 532
+ E E RE +L+ +R +VE +E + ++ T++ L+A ++R
Sbjct: 1855 AQLEAEKREVERSALRLEKDRVALRRTLDKVE--REKLRSHEDTVR----LSAEKGRLDR 1908
Query: 533 ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 578
LT + E Q+Q + + ++ E +E++ +Q ++
Sbjct: 1909 TLTGAELELAEAQRQ--IQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Score = 63.5 bits (153), Expect = 1e-09
Identities = 177/868 (20%), Positives = 343/868 (39%), Gaps = 115/868 (13%)
Query: 198 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ 257
+PVL + L S +E + L+ ++ +E+ L R +R E K + + +LEQ
Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQ 120
Query: 258 VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER 317
+ E Q E R ++++E + + EE A ++ ++ +
Sbjct: 121 ALRLEPGELETQ--------EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL 172
Query: 318 AESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM 377
+ LQ ++ K+R EL L E+E+ Q + E + L+ AL+R+
Sbjct: 173 VQRLQGKILQYKKRCSELEQQLLERSGELEQ----------QRLRDTEHSQDLESALIRL 222
Query: 378 RD---LSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQEELSQAESTIDELK 427
+ S+S Q + L++ +++ ++++ V R ++EL E+ +
Sbjct: 223 EEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282
Query: 428 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ---ENARETELE 484
E +A E R L L +V R V +++ E D LQ E AR +
Sbjct: 283 ESFNAYFSNEH------SRLLLLWRQVVGFRRLVSEVKMFTE-RDLLQLGGELARTSRAV 335
Query: 485 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 544
L ++ +R A+ R EAA ++K L A L++ R+ +++ ++
Sbjct: 336 QEAGLGLS-TGLRLAESRAEAA----------LEKQALLQAQLEEQLRDKVLREKDLAQQ 384
Query: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 604
Q Q + D + E K +E + +E Q N+ ++ + L+ +
Sbjct: 385 QMQSDLDKADLSARVTELGLAVKRLEKQ--NLEKDQVNKDLTEKLEALESLRLQEQAALE 442
Query: 605 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERP------GLRGAAGEQL-------- 650
L L A+ + ++ +LS SER LRG +G++
Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSG--SERTADASNGSLRGLSGQRTPSPPRRSS 500
Query: 651 -----------SFAAGLVYSLSLLQATLHRYEHALS------QCSVDVYKKVGSLYPEMS 693
S A +L+L+ + LH+ + + + S D+ + +
Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560
Query: 694 AHERSLDFLIELLHKDQLDETVNV-EPLTKAIKYYQHLYSIHLAEQPE-----DCTMQLA 747
+ R+L+ ++ L +D+ D + E + ++ + + E+ Q A
Sbjct: 561 SERRALEEQLQRL-RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619
Query: 748 DHIKFTQSALDCMSVEVGRLRAFLQGGQE--ATDIALLLRDLETSCSDIRQFCKKIRRRM 805
+ ++ + L E+ R R L+ QE D A + R+LE S + Q + +R +
Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL--EGKRSV 677
Query: 806 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 865
+ + AL+ D L A EVA A + A E E ++
Sbjct: 678 LAKELVEVREALSRATLQRDML----------QAEKAEVAEALTKAEAGRVELE---LSM 724
Query: 866 LEELAFKASEQIYGTPSSSPYECLRQ---SCNILISTMNKLATAMQEGEYDAERPPSKPP 922
+ A +AS Q + S+ E L Q N L++ + + +A+Q + AE+ +
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 923 PVELRAAALRAEITDA-EGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLD 981
+ R LR E A +GL L E + L++ L E S+ +L+ L ++L
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
Query: 982 SAAKDADERIEKVQTRLEETQALLRKKE 1009
++ ++ + Q ++E + R+KE
Sbjct: 845 GREQELEQARREAQRQVEALERAAREKE 872
Score = 50.8 bits (120), Expect = 8e-06
Identities = 214/1026 (20%), Positives = 391/1026 (38%), Gaps = 153/1026 (14%)
Query: 323 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 382
QEVE E V + T + +L +EKG GA Q Q+ A +++ + R +LS
Sbjct: 9 QEVELTLETVIQ-TLESSVL---CQEKGL-GARDLAQDAQITSLPALIREIVTR--NLSQ 61
Query: 383 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 442
E + ++ L ++++ + LQ+ELS+ E + + + + D V
Sbjct: 62 PESPVLLPATEMAS-----LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE 116
Query: 443 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 502
++ L LE E +E G + E+ +LQE +L+ + + R+AQ
Sbjct: 117 RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE---GQQRQAQ-L 172
Query: 503 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 562
V+ Q + Y+ K+ +L L + + EL Q+ E Q + + +
Sbjct: 173 VQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229
Query: 563 KAHAKAIEMELRQMEVA-QANRHMSLLTAFMPDSFLRP---------------------- 599
+ A+ M Q++ A AN+ +S + + + R
Sbjct: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289
Query: 600 GGDHDCVLVL----LLMPRLICKAELIRK----QAQEKFELSENCSERPGLRGAAGEQL- 650
+H +L+L + RL+ + ++ + Q + + + GL + G +L
Sbjct: 290 SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349
Query: 651 -SFAAGLVYSLSLLQA---------TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
S A + +LLQA L + A Q D+ K ++SA L
Sbjct: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK------ADLSARVTELG 403
Query: 701 FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCM 760
++ L K L++ + LT+ + + L S+ L EQ ++ D Q+ D
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKL---EALESLRLQEQ---AALETEDGEGLQQTLRDL- 456
Query: 761 SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFG 820
+A L + ++ R + S +R + P +PG + G
Sbjct: 457 ------AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510
Query: 821 PQV----SDTLLDCRKHLTWVVAVLQEVAA---AAAQLIAPL------AENEGLLVAALE 867
P S TL L +Q++ A+ L+ L +E+E ALE
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESER---RALE 567
Query: 868 ELAFKASEQIYGT-----PSSSPYECLRQSCNILISTMNKLATAMQEGEYDA-----ERP 917
E + ++ G + + LR + +L + LA ++Q + A ER
Sbjct: 568 EQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627
Query: 918 PSKPPPVELRAAALRAE------ITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANV 971
+ ELR R E + D + +LE +++L+ + +EL E
Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687
Query: 972 RLS--LLEKKLDSAAK----DADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQ 1025
LS L++ + A K +A + E + LE + LR +E ++++ L A +
Sbjct: 688 ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNES 747
Query: 1026 LEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPG 1085
L +K +L RL +Q + L+G A + +A EEQ+R + V G
Sbjct: 748 LAQDKLDL-NRLVAQLEEEKSALQGRQRQ--AEQEATVAREEQER-LEELRLEQEVARQG 803
Query: 1086 LVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPA 1145
L + Q A+ + L+HE S L+ +A+LS + G E
Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQE-------------QLAQLSRQLSGREQEL 850
Query: 1146 GALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDE 1205
R+ + +E L + + + A QL+ + ++LS+ +L+ E
Sbjct: 851 EQARREAQRQVEALERAAREKEALAKEHAGLA-----VQLVAAEREGRTLSEEATRLRLE 905
Query: 1206 VLKETVSQRPGATVPTDFATFPSSAFLRAKEEQ---QDDTVYMGKVTFSCAAGFGQRHRL 1262
KE A + F A L A+ EQ + + + K T + G R ++
Sbjct: 906 --KE-------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA-GLRQQI 955
Query: 1263 VLTQEQ 1268
+ TQE+
Sbjct: 956 IATQEK 961
Score = 40.8 bits (94), Expect = 0.008
Identities = 75/372 (20%), Positives = 147/372 (39%), Gaps = 72/372 (19%)
Query: 86 GIFVRQSQIQVFEDGADTTSPETPDSSA----------------SKVLKREG-------- 121
G+ R++Q Q +D D+ + DS +KV + EG
Sbjct: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRG 1730
Query: 122 -TDTTAKTS------KLRGLKPKKAPTA----RKTTTRRPKPTRPASTGVAGASSSLGPS 170
T+ A++S + + L +KA TA R+ R R A + SSSLG
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790
Query: 171 GSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEK 230
GE++ E + G L + K L+ + R L+E+
Sbjct: 1791 VQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK----LQDERRLLQER 1846
Query: 231 LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAK 290
L +L+ A+ +A+ +E+E+ ++LE + + L+R L + +E + E
Sbjct: 1847 LGSLQRALAQLEAEKREVERSALRLE----------KDRVALRRTLDKVEREKLRSHEDT 1896
Query: 291 ERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKG 350
R E + A L+ A+ + + L+ +V L++ +++ + ++E
Sbjct: 1897 VRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLE--- 1953
Query: 351 SDGAASSYQLKQLEEQNARLKDALVRM-RDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 409
L+++ RL+ A + R L + E+ +++ L E+ V +
Sbjct: 1954 ------------LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-------VSTLK 1994
Query: 410 ERLQEELSQAES 421
+LQ+EL ++ +
Sbjct: 1995 GQLQQELRRSSA 2006
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 99.0 bits (245), Expect = 3e-20
Identities = 221/1036 (21%), Positives = 394/1036 (38%), Gaps = 155/1036 (14%)
Query: 128 TSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPA 187
+S L+ + + A K R + +T +SL A+ +L + E A
Sbjct: 557 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER-DAALKQLEALEKEKAA 615
Query: 188 QTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKE 247
+ + + A + +E+ L +V +L+ +ET R ++ E +A++ E
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 248 LE-------KHKIQLEQVQEWKSKMQEQQADLQRRLK-------EARKEAKEALEAKERY 293
LE + + E+V + K ++QEQ L+ LK E ++ A +ALE ++R
Sbjct: 676 LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRC 735
Query: 294 MEEM-ADTADAIEMATLD-KEMAEERA-------------ESLQQEVEALKERVDELTTD 338
+ E+ A+T +E + KE+ EERA E+ Q E E L+ + E
Sbjct: 736 ISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA 795
Query: 339 LEILKAEIEEKGSDGAA--SSYQLKQLEE--QNARLKDALVRMRDLSSSEKQEHVKLQKL 394
++E E+ + AA Y+ Q EE A ++ L+ +++ +QE LQ+
Sbjct: 796 QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE---LQEA 852
Query: 395 MEK-----KNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
EK + EL++ RQ Q EL++ + + +QV E + L D
Sbjct: 853 KEKVAGIESHSELQISRQ-----QNELAELHANLARALQQVQE---KEVRAQKLADDLST 904
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE----------- 498
L+EK+ + V LE + E QE A EL ++ AG R E
Sbjct: 905 LQEKMAATSKEVARLETLVRKAGEQQETASR---ELVKEPARAGDRQPEWLEEQQGRQFC 961
Query: 499 -AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKI 557
Q ++A + +++ R Q +E QQE V R Q E +
Sbjct: 962 STQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQ---ERGRAQA 1018
Query: 558 KFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLIC 617
A KA +EM L+ Q +L A + G D + + L I
Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078
Query: 618 KAELIRKQAQE-KFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 676
+ E +R+ ++ K +L++ E GA E L L+A + + E Q
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE---QQ 1135
Query: 677 CSVDVYKKVGSLYPEMSAHERS---LDFLIELLHKDQLDETVN--------VEPLTKAIK 725
C ++ SL + A S D +E L + QL+E + + +
Sbjct: 1136 CQKQ-QEQADSLERSLEAERASRAERDSALETL-QGQLEEKAQELGHSQSALASAQRELA 1193
Query: 726 YYQHLYSIHLAEQPEDCTMQLA---DHIKFTQSALDCMSVEVGRL-RAFLQGGQEATDIA 781
++ H ++ ++ Q+A + S + + EV L R L+ E+ ++
Sbjct: 1194 AFRTKVQDH-SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
Query: 782 LLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVL 841
L+ + + + ++ A + A +V + K +
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR 1312
Query: 842 QEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM- 900
QE+ + A + AE G + A +E F+ + + S + S L+S +
Sbjct: 1313 QELTSQAER-----AEELGQELKAWQEKFFQKEQAL------STLQLEHTSTQALVSELL 1361
Query: 901 --NKLATAMQEGEYDAER------PPSKPPPVELRAAALRA--EITDAEGLGLKLEDRET 950
L +Q + AE+ SK LRA LRA E+ + L K+ ++E
Sbjct: 1362 PAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER 1421
Query: 951 VIKELKKSLKIKGEELS------------------EANVRLSLLEKKLDSAAK------- 985
++L+ E+LS AN+ LE +LD A +
Sbjct: 1422 TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELA 1481
Query: 986 ----DADERIEKVQTRLEETQALLR--------------KKEKEFEETMDALQADIDQLE 1027
DA+ R+ +VQ + T L ++ + F+E L A ++QLE
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541
Query: 1028 AEKAELKQRLNSQSKR 1043
+ E +++ SK+
Sbjct: 1542 VFQREQTKQVEELSKK 1557
Score = 92.8 bits (229), Expect = 2e-18
Identities = 226/1108 (20%), Positives = 419/1108 (37%), Gaps = 195/1108 (17%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ------------VQEWK 262
K+ + L+ + ++ K+ L + + KL+E H QL+ QEW
Sbjct: 297 KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 356
Query: 263 SKMQEQQADLQRRL--KEARKEAKEALEAK----ERYMEEMADT---------ADAIEMA 307
K + + +L L K+ +E E L+ K E ++ ++ D D +++
Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
Query: 308 TLDKEMA---------EERAESL-----QQEVEALKER---------VDELTTDLEI--- 341
TL +E A + R E L QQE + L ER + L TDL+
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476
Query: 342 ----LKAEIEEKG-SDGAASSYQLKQLEEQ----NARLKDALVRMRDLSSSEKQEHVKLQ 392
K E+E+ + GA + Q+ L + NA ++ + L K++ +L
Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536
Query: 393 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA---------ALGAEEMVEML 443
+ ++++ Q + +R Q E+L L Q E + E+ E+ +A A AEE L
Sbjct: 537 QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 444 TDRNLNL-------EEKVRELRETVGDLEAMNEMNDELQEN---ARETELELREQLDMAG 493
+R+ L +EK +L L+ NE D Q + A+ + EL +++
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 494 ARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE-------------A 540
A V A++ AQ VA+ + ++ +Q + V +E QE
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 541 SVERQQQPPPETFDFKIKF-----AETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 595
S+E +++ + + + + AET++ + + E +++E +A R +
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR------KGLEAR 770
Query: 596 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE--LSENCSERPGLRGAAGEQLSFA 653
+ G H +L R + +A + A+ + E + E + R + E+ +
Sbjct: 771 LQQLGEAHQAETEVL--RRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 654 AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDE 713
A L L+ + L + +KV + +H EL Q +E
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAK----EKVAGI----ESHS-------ELQISRQQNE 873
Query: 714 TVNVEP-LTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQ 772
+ L +A++ Q + E +LAD + Q + S EV RL ++
Sbjct: 874 LAELHANLARALQQVQ---------EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 773 --GGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDC 830
G Q+ T L+++ + ++ ++ + R + + A Q+ + L
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 831 RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA--ALEELAFKASEQIYGTPSSSPYEC 888
R L QE + +A L + G A ALE+ A E
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-------RLQNA 1037
Query: 889 LRQSCNILISTMNKLATAMQEGE-YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLED 947
L + + LA A+ E E D E + L AA ++ +LE+
Sbjct: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLR----GLEAAQIK-----------ELEE 1082
Query: 948 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRK 1007
+K+LK+ L K +E + + A +A R E +LE +A + K
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGS-----------GAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 1008 KEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEE 1067
E++ ++ + + LEAE+A +R + T++G + S +A +
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSALASAQ 1189
Query: 1068 QQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLP 1127
++ A + K Q++ R + + +NS++ + + S+
Sbjct: 1190 RELAAFRTKVQDHSKAEDEWK------AQVARGR---QEAERKNSLISSLEEEVSI---- 1236
Query: 1128 PLHVAKLSHEGPGSELP--AGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQL 1185
L+ L EG EL A K+ +L E L L T S A S+ L
Sbjct: 1237 -LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAET-----ASNSARAAERSSAL 1290
Query: 1186 MEQVAQLKSLSDTVEKLKDEVLKETVSQ 1213
E+V L+ ++ + + +E SQ
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQ 1318
Score = 87.8 bits (216), Expect = 6e-17
Identities = 209/1042 (20%), Positives = 418/1042 (40%), Gaps = 120/1042 (11%)
Query: 223 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQL--------EQVQEWKSKMQEQQADLQR 274
++ +L +K E+L ++ E + ++L+ K Q+ E+ + K++E + LQ+
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
+ +E +A + ++E+ A + A DK+ EE+ E LQ ++ L+E + +
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
L + K E+ QL+ L+++ A L+++ Q +++ L
Sbjct: 397 LQDNPPQEKGEV-------LGDVLQLETLKQEAA----------TLAANNTQLQARVEML 439
Query: 395 MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTD-RNLNLEEK 453
++ Q+ + +R +EE Q S I +L+ + A+E +E + L +
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 454 VRELRETVGDLEAMNEMNDE----LQENARETELELREQLDMAGARVREAQKRVEAAQET 509
V L + L A + D+ L++ A+E + +L + L + + +VE +
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q +K+ A Q+ R+ QQ A+ +++ D +K E KA
Sbjct: 560 LKQKEQQLKE----VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 570 EMELRQMEVAQANR-----HMSLLTAFMPDSFL-RPGGDHDCVLVLLLMPRLICKAELIR 623
++E+ Q ++ AN S+ A + L R + + + +A++
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 624 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 683
+ Q + E + +E+ + + L SL + + +L + + D +
Sbjct: 676 LELQLRSE-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR----AADALE 730
Query: 684 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ E+ A RSL + K+ +E + L + Q L H AE E
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEAHQAE-TEVLR 786
Query: 744 MQLADHI---KFTQSALDCMSVEVGRLRAFLQGGQ--EATDIALL---LRDLETSCSDIR 795
+LA+ + +S + + EV R + Q EA A+ L L+ C R
Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 796 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 855
Q ++ + ++ G ++ + L Q ++ L + +L + +QE A +L L
Sbjct: 847 QELQEAKEKVAGIES---HSELQISRQQNE-LAELHANLARALQQVQEKEVRAQKLADDL 902
Query: 856 AENEGLL------VAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE 909
+ + + VA LE L KA EQ ++ E +++ ++
Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQ----QETASRELVKEPAR----------AGDRQ 948
Query: 910 GEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEA 969
E+ E+ + + AAL+A +AE +G +LE + E S + EE +
Sbjct: 949 PEWLEEQQGRQFCSTQ---AALQAMEREAEQMGNELERLRAALME---SQGQQQEERGQQ 1002
Query: 970 NVRLSLLEKKLDSAAKDADERIEK-VQTRLE-ETQALLRKKEKEFEETMDALQADIDQLE 1027
++ L ++ A AD +EK + LE Q L ++ EF +AL + + E
Sbjct: 1003 EREVARLTQERGRA--QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 1028 AEKAELK--QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPG---QAPGSVP 1082
+ EL + L + + +E LR + L +A +E++ + G +A G
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELR----QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116
Query: 1083 GPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSE 1142
G ++ A+R +S+L E K + SL A + E
Sbjct: 1117 PTG---------PKLEALRAEVSKL--EQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 1143 LPAGALYRKTSQLLETLNQLST--------HTHVVDITRTSPAAKSPSAQLMEQVAQLKS 1194
G L K +L + + L++ T V D ++ K+ A+ ++ + S
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225
Query: 1195 LSDTVEKLKDEVLKETVSQRPG 1216
L ++E+ + +L V ++ G
Sbjct: 1226 LISSLEE-EVSILNRQVLEKEG 1246
Score = 85.9 bits (211), Expect = 2e-16
Identities = 192/926 (20%), Positives = 358/926 (38%), Gaps = 159/926 (17%)
Query: 205 GAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 264
G V L + +E L A L+ ++E L +R + +AKL H E+ Q+ S
Sbjct: 410 GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE--EEKQQLSSL 467
Query: 265 MQEQQADLQRRLKEARKEAKEALEAK-ERYMEEMADTADAIEMATLD------------- 310
+ + Q+ + L +A++E ++A +A R ++A E+ TL+
Sbjct: 468 ITDLQSSISN-LSQAKEELEQASQAHGARLTAQVASLTS--ELTTLNATIQQQDQELAGL 524
Query: 311 KEMAEER----AESLQQEVEA---LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ- 362
K+ A+E+ A++LQQ+ +A L+ +V++L++ L+ + +++E A+ Q
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584
Query: 363 ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 418
EE+ A L++ ++ L + EK++ KL+ L Q+L+V + R+ Q ++Q
Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKLEIL----QQQLQVANEARDSAQTSVTQ 640
Query: 419 AESTIDELKEQVD--------AALGAEEMVEMLTDRNLNL---EEKVRELRETVGDLEAM 467
A+ EL +V+ A E + + L L ++K E + + +
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700
Query: 468 NEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL 527
E L+E+ + T+ L E+ A + E Q+ + E A+ + ++++++ L
Sbjct: 701 QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI---SELKAETRSLVEQHKRERKEL 757
Query: 528 QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANRHM 585
++ + + + ET + + AE A E E Q+ EVA
Sbjct: 758 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER- 816
Query: 586 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 645
+ + +L+ E K QE E E + G+
Sbjct: 817 -----------YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESH 862
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK---KVGSLYPEMSAHERSLDFL 702
+ Q+S L+ L A L R + + V K + +L +M+A + + L
Sbjct: 863 SELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919
Query: 703 IELLHK-DQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDC-- 759
L+ K + ET + E + + + QPE Q TQ+AL
Sbjct: 920 ETLVRKAGEQQETASRELVKEPARAGD--------RQPEWLEEQQGRQFCSTQAALQAME 971
Query: 760 -----MSVEVGRLRAFL---------QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRM 805
M E+ RLRA L + GQ+ ++A L ++ + +D+
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL----------- 1020
Query: 806 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 865
A A ++ + L + R + L LA+ GL A
Sbjct: 1021 ----ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 866 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 925
++EL E LRQ+ L + K G + P
Sbjct: 1077 IKEL-----------------EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
Query: 926 LRAAALRAEIT-----------DAEGLGLKLE-------DRETVIKELKKSLKIKGEE-- 965
+ ALRAE++ A+ L LE +R++ ++ L+ L+ K +E
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG 1179
Query: 966 -----LSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE--KEFEETMDA 1018
L+ A L+ K+ +K DE +V +E + RK EE +
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE---RKNSLISSLEEEVSI 1236
Query: 1019 LQADIDQLEAEKAELKQRLNSQSKRT 1044
L + + E E ELK+ + ++S+++
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKS 1262
Score = 76.3 bits (186), Expect = 2e-13
Identities = 189/876 (21%), Positives = 334/876 (38%), Gaps = 114/876 (13%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS----KMQEQQAD 271
+E+ +RAQ L + L TL+ K A ++ LE + + QE S K + D
Sbjct: 889 QEKEVRAQ--KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946
Query: 272 LQRRLKEARK-----EAKEALEAKERYMEEMADTADAIEMATLDKE--MAEERAESLQQE 324
Q E ++ + AL+A ER E+M + + + A ++ + EER + ++E
Sbjct: 947 RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ-ERE 1005
Query: 325 VEALKERVDELTTDLEILKA---EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 381
V L + DL + KA E+E + + L + + A L++AL
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNA------LNEQRVEFATLQEALAHALTEK 1059
Query: 382 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE--- 438
+ QE KL+ L + +ELE +RQ ++L+E+L++ E A G E
Sbjct: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
Query: 439 -MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARV 496
+E L LE++ ++ +E LE E + R++ LE L+ QL+ +
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEA-ERASRAERDSALETLQGQLEEKAQEL 1178
Query: 497 REAQKRVEAAQETVADYQQTIKKYR--------QLTAHLQDVNRE----LTNQQEASVER 544
+Q + +AQ +A ++ ++ + Q+ Q+ R+ + ++E S+
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238
Query: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 604
+Q E ++K K+ ++E R + + QA + A S LR
Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEER-LRLLQAETASNSARAAERSSALRE----- 1292
Query: 605 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQ 664
+ + +R++A+++ SEN LR Q A L L Q
Sbjct: 1293 -------------EVQSLREEAEKQRVASEN------LRQELTSQAERAEELGQELKAWQ 1333
Query: 665 ATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAI 724
+ E ALS ++ H + + ELL L + + E
Sbjct: 1334 EKFFQKEQALSTLQLE--------------HTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 725 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 784
++ + L EQ + L + Q E+G L Q E A L
Sbjct: 1380 RHREEL------EQSKQAAGGLRAELLRAQR-------ELGELIPLRQKVAEQERTAQQL 1426
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHL---------- 834
R + S ++ KK + + G+ G Q + LD +
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLL-AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485
Query: 835 ---TWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQ 891
T + V +E + A +L A+ EG V LEE E+ T E ++
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545
Query: 892 SCNILISTMNK-LATAMQEGEYDAER---PPSKPPPVELRAAALRAEITDAEGLGLKLED 947
+ ++K LA + Q + ++ ++ + A L+A++ + + + E
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
Query: 948 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE-RIEKVQTRLEETQALLR 1006
K + K + + N L + L+ K+ E R E + E QA L
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL- 1664
Query: 1007 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 1042
K KE E+T L A + LEA+ A Q+L K
Sbjct: 1665 -KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/356 (22%), Positives = 151/356 (42%), Gaps = 55/356 (15%)
Query: 219 GLRAQV----RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
GLRA++ R+L E L LR K AE + ++L K + K A+ R
Sbjct: 1394 GLRAELLRAQRELGE-LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 275 RLKEARKEAKEALE-----AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
L E ++ LE A+E+Y++E+A + AE R +Q+E ++
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAV----------RADAETRLAEVQREAQSTA 1502
Query: 330 ERVDELTTDLEILKAEIEEKGS----DGAASSYQLKQLE----EQNARLKDALVRMRDLS 381
++ +T E K ++ E+ + + Q++QLE EQ ++++ ++ D
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562
Query: 382 SSEKQEHVKLQKLMEK---KNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
+ K + KL+ + + QE + ++ Q LQ +LSQ E + K Q++ A +
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA---KT 1619
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
+ +N L+E++R L E ++ ELR + + G +++
Sbjct: 1620 HYDAKKQQNQELQEQLRSL------------------EQLQKENKELRAEAERLGHELQQ 1661
Query: 499 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPPPE 551
A + + A++T ++ AH R+L Q +A R+ Q P+
Sbjct: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717
Score = 65.5 bits (158), Expect = 3e-10
Identities = 82/399 (20%), Positives = 178/399 (44%), Gaps = 37/399 (9%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI-QLEQVQEWKSKMQEQQADLQ 273
+E E + + LEE++ L + E + + KEL++ + + E+ Q+ + +++ QA+
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
A + + E + EE A E + ERAE L QE++A +E+
Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF 1337
Query: 334 ELTTDLEILKAE-----------------IEEKGSDGAASSYQLKQLEEQNARLKDALVR 376
+ L L+ E ++ ++ AA+ + ++ EQ+ + L
Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG- 435
+ E E + L++ + ++ + + +R ++ E+LS + L E+ + LG
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGE 1456
Query: 436 ----AEEMVEMLTDRNLNLEEKVRELRETVGDLEA-MNEMNDELQENARETELELREQLD 490
+ +E+ D+ E+ V+EL D E + E+ E Q ARE E+ +
Sbjct: 1457 RANLGRQFLEVELDQ--AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK--- 1511
Query: 491 MAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 547
GA+V+ E Q+ E Q+ A +Q R+ T +++++++L + +AS +QQ+
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571
Query: 548 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 586
+ + E++ A+ ++ +L +++ + + +
Sbjct: 1572 LKA----VQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Score = 56.2 bits (134), Expect = 2e-07
Identities = 73/328 (22%), Positives = 133/328 (40%), Gaps = 73/328 (22%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----------------------KIQLEQ 257
LR +V + E + LR ++A +L L+K +++L+Q
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471
Query: 258 VQE-WKSKMQEQQADLQRRLKEARKEAK------------------EALEAKERYMEEMA 298
+E + ++ +AD + RL E ++EA+ + LE ++R+ EE
Sbjct: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER- 1530
Query: 299 DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 358
+ T E E ++VE L +++ + ++ + +++ + G S
Sbjct: 1531 ------QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
Query: 359 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 418
+ ++L+ Q L+ L + + EH KLQ MEK + +QQ + LQE+L
Sbjct: 1585 EAQRLQAQLNELQAQLSQ-----KEQAAEHYKLQ--MEKAKTHYDAKKQQNQELQEQLRS 1637
Query: 419 AESTIDELKEQVDAA--LG------------AEEMVEMLTDRNLNLEEKVRELRETVGDL 464
E E KE A LG AE+ LT + +LE +V + + DL
Sbjct: 1638 LEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Query: 465 EAMNEMNDELQENARETELELREQLDMA 492
D L + E + + QLD++
Sbjct: 1698 GKFQVATDAL----KSREPQAKPQLDLS 1721
Score = 53.1 bits (126), Expect = 2e-06
Identities = 197/982 (20%), Positives = 370/982 (37%), Gaps = 134/982 (13%)
Query: 305 EMATLDKEMAEERAESLQQEVEALKER--VDELTTDLEILKAEIE------EKGSDGAAS 356
+M L K++A+ER+ + E+E + R + E + +++ I+ EK +
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 357 SYQLKQLEEQN----ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKN----------QEL 402
+L++L ++N RL + L + +DL + + Q K+ +L E+ L
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 403 EVVRQQRERLQEELSQAESTIDELKEQVDAALGA--------EEMVEMLTDRNLNLEEKV 454
+ ++ L EE S+A E + Q++ L A EE E+L + LEE +
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 455 RELRETVGDLEAMNEMNDELQ-ENARETELELREQLDMAGARVREAQ-KRVEAAQETVAD 512
+L++ E + D LQ E ++ L ARV + +R + + +A+
Sbjct: 395 SQLQDNPPQ-EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453
Query: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 572
++ +QL++ + D+ ++N +A E +Q + A + +
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 573 LRQMEVAQA-------NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
++Q + A + L G H V L L K + +++
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ---VEQLSSSLKQKEQQLKEV 570
Query: 626 AQEK--------FELSENCSERPGL---RGAAGEQL-SFAAGLVYSLSLLQATLHRYEHA 673
A+++ +L+ ER R AA +QL + L +LQ L A
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 674 LSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS- 732
V + E+S L +E ++Q + V L ++ Q +
Sbjct: 631 RDSAQTSV-TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
Query: 733 ----IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLE 788
+Q ++ L + +K T+ +L+ E R L+ Q + +L+
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLE---EEKRRAADALEEQQRC------ISELK 740
Query: 789 TSCSDIRQFCKKIRRRMPGTDA--PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAA 846
+ + K+ R+ + A G+ A L Q+ + H + +E+A
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEA------HQAETEVLRRELAE 791
Query: 847 AAAQLIAPLAENEGLL--VAALEELAFKASEQ---IYGTPSSSPYECLRQSC----NILI 897
A A +E E L+ VAA E ++ S+Q YG L++ C L
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRE-RYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850
Query: 898 STMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKK 957
K+A E R ++ + A ++ + E KL D + ++E
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE--- 907
Query: 958 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA--LLRKKEKEFEET 1015
K S+ RL L +K + A + K R + Q L ++ ++F T
Sbjct: 908 ----KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963
Query: 1016 MDALQA---DIDQLEAEKAELKQRL-NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 1071
ALQA + +Q+ E L+ L SQ ++ E RG +A L Q+RG
Sbjct: 964 QAALQAMEREAEQMGNELERLRAALMESQGQQQEE--RGQQEREVARLT-------QERG 1014
Query: 1072 AIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQH--ENSILKGAQMKASLASLPPL 1129
QA ++ + L ++ R+ + LQ +++ + LA L L
Sbjct: 1015 R--AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 1130 HVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTS-PAAKSPSAQLMEQ 1188
A++ ++ +L +T+ QL + S A+S +A E
Sbjct: 1073 EAAQI---------------KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117
Query: 1189 VA-QLKSLSDTVEKLKDEVLKE 1209
+L++L V KL+ + K+
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQ 1139
Score = 41.2 bits (95), Expect = 0.006
Identities = 197/985 (20%), Positives = 373/985 (37%), Gaps = 143/985 (14%)
Query: 350 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 409
GS + L+ + Q RLK L R + E + +KL+ +K+ ++ +++Q+
Sbjct: 199 GSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258
Query: 410 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA--- 466
+RL + ++E +Q + L +E+ E L D+N +L ++ E + DL+
Sbjct: 259 DRL--------ALLNE--KQAASPLEPKEL-EELRDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 467 --------MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 518
++E N +L RE L++ D E K + E A ++ +
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367
Query: 519 KYRQLTAHLQDVNR----ELTNQQEASVERQQQPPPETFD----------FKIKFAETKA 564
Q L++ N +L+ +E + Q PP E + K + A A
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427
Query: 565 HAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 624
+ ++ + +E + + LL R + + + L+ L I
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAE-------RGHFEEEKQQLSSLITDL---QSSISN 477
Query: 625 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 684
+Q K EL E S+ G R A A L L+ L AT+ + + L+ +K
Sbjct: 478 LSQAKEEL-EQASQAHGARLTAQ-----VASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 685 VGSLYPEMSAHERS---LDFLIELL------HKDQLDETVNVEPLTKAIKYYQHLYSIHL 735
L + E++ L +E L + QL E + T+ H +
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR----QDHAQQLAT 587
Query: 736 AEQPEDCTMQLADHIKFTQSALDC-MSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 794
A + + +++ D AL+ + ++ L+ LQ EA D A +TS +
Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA------QTSVTQA 641
Query: 795 RQFCKKIRRRMPGTDAPGIPA------ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAA 848
++ ++ R++ A A A A ++ L ++ T V QE
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 849 AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQ 908
QL A L E+ + +LEE +A++ + C+ + + T + + +
Sbjct: 702 EQLQA-LKESLKVTKGSLEEEKRRAADAL-----EEQQRCISE---LKAETRSLVEQHKR 752
Query: 909 E-GEYDAERPPSKPPPVELR---------AAALRAEITDAEGLGLKLEDR-ETVIKEL-- 955
E E + ER K L+ LR E+ +A E E ++KE+
Sbjct: 753 ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812
Query: 956 -----KKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEK 1010
+ S + + + + +L L+++ + A ++ E EKV ++ + +++
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQN 872
Query: 1011 EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGI--AGEEQ 1068
E E L + Q++ EK Q+L + T++ +A L + + AGE+Q
Sbjct: 873 ELAELHANLARALQQVQ-EKEVRAQKL-ADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
Query: 1069 Q---RGAIPGQAPGSVPGPGLVKDSP-----LLLQQISAMRLHISQLQHENSILKGAQMK 1120
+ R + A P +++ + AM Q+ +E L+ A M+
Sbjct: 931 ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALME 990
Query: 1121 A-----SLASLPPLHVAKLSHEGPGSE----LPAGALYRKTSQLLETLN----QLSTHTH 1167
+ VA+L+ E ++ L A +L LN + +T
Sbjct: 991 SQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE 1050
Query: 1168 VVDITRTSPAAKSPSAQLME-----QVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTD 1222
+ T K + Q+ +L+ L TV++LK+++ K+ G+ ++
Sbjct: 1051 ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 1223 FA-----TFPSSAFLRA---KEEQQ 1239
A T P LRA K EQQ
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQ 1135
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 96.3 bits (238), Expect = 2e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 215 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 269
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 330 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 389
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 390 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205
Query: 570 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 616
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 617 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 671
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 672 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 728
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 729 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 784
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473
Query: 845 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 888
A A A+ E + L +A E A +A E++ T E
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 948
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587
Query: 949 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 1005
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 1006 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1062
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 1063 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 1121
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 1122 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1175
+ +LS+E A QL +L + H ++ T
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 1176 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1213
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 230 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 288
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 289 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 348
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933
Query: 349 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 408
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 409 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 456
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052
Query: 457 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105
Query: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 570
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 571 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 630
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206
Query: 631 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
EL+E + + + A L L +L EH + V +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263
Query: 687 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 741
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 742 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 785
+Q K S L + E L+ L EA +D L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 786 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 845
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430
Query: 846 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 904
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539
Query: 965 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1023
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 1024 DQLEAE-KAELKQR-LNSQSKRTIEG 1047
+ E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624
Score = 79.3 bits (194), Expect = 2e-14
Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 269
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198
Query: 330 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 371
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 372 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 533
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 534 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 585
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491
Query: 586 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 645
L L K EL R K E+ + S + +
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 705
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580
Query: 706 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 765
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 766 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 823
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 824 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 883
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 884 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 943
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 1003
K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+
Sbjct: 1809 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1861
Query: 1004 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 1043
RK ++++E + A + QL+ E E QR+N+ ++
Sbjct: 1862 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 338
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737
Query: 339 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 398
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793
Query: 399 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1891
Query: 514 QQTIKKYRQLTAHLQDVNRELTNQQEAS 541
+ +++ A+ + + REL E++
Sbjct: 1892 -----ESQRINANRRKLQRELDEATESN 1914
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 258
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 318
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 319 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 378
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 379 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 439 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 485
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 605
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643
Query: 606 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 716
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 717 VEPLTKAIK 725
+E ++ ++
Sbjct: 1752 MEAMSDRVR 1760
Score = 64.3 bits (155), Expect = 7e-10
Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)
Query: 201 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 256
L + A+ K+ L+AQ++D + +LE R R E A KE EK LE
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 257 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 296
Q+QE ++ +QADL++ + A ++ K LEA+ +EE
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 297 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 327
M +D + AT L E+A ER+ ES +Q++E
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 328 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386
K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1863
Query: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 446
+ ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1919
Query: 447 NLN-LEEKVRELRET 460
+N L+ K+R ET
Sbjct: 1920 EVNALKSKLRRGNET 1934
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 96.3 bits (238), Expect = 2e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 215 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 269
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 330 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 389
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 390 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212
Query: 570 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 616
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 617 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 671
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 672 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 728
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 729 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 784
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480
Query: 845 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 888
A A A+ E + L +A E A +A E++ T E
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 948
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594
Query: 949 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 1005
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 1006 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1062
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 1063 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 1121
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 1122 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1175
+ +LS+E A QL +L + H ++ T
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 1176 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1213
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 230 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 288
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 289 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 348
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940
Query: 349 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 408
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 409 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 456
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059
Query: 457 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112
Query: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 570
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 571 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 630
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213
Query: 631 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
EL+E + + + A L L +L EH + V +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270
Query: 687 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 741
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 742 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 785
+Q K S L + E L+ L EA +D L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 786 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 845
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437
Query: 846 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 904
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546
Query: 965 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1023
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 1024 DQLEAE-KAELKQR-LNSQSKRTIEG 1047
+ E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631
Score = 79.3 bits (194), Expect = 2e-14
Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 269
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205
Query: 330 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 371
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 372 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 533
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 534 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 585
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498
Query: 586 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 645
L L K EL R K E+ + S + +
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 705
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587
Query: 706 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 765
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 766 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 823
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 824 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 883
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 884 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 943
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 1003
K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+
Sbjct: 1816 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1868
Query: 1004 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 1043
RK ++++E + A + QL+ E E QR+N+ ++
Sbjct: 1869 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 338
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744
Query: 339 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 398
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800
Query: 399 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1898
Query: 514 QQTIKKYRQLTAHLQDVNRELTNQQEAS 541
+ +++ A+ + + REL E++
Sbjct: 1899 -----ESQRINANRRKLQRELDEATESN 1921
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 258
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 318
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 319 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 378
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 379 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 439 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 485
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 605
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650
Query: 606 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 716
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 717 VEPLTKAIK 725
+E ++ ++
Sbjct: 1759 MEAMSDRVR 1767
Score = 64.3 bits (155), Expect = 7e-10
Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)
Query: 201 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 256
L + A+ K+ L+AQ++D + +LE R R E A KE EK LE
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 257 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 296
Q+QE ++ +QADL++ + A ++ K LEA+ +EE
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 297 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 327
M +D + AT L E+A ER+ ES +Q++E
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 328 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386
K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1870
Query: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 446
+ ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1926
Query: 447 NLN-LEEKVRELRET 460
+N L+ K+R ET
Sbjct: 1927 EVNALKSKLRRGNET 1941
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 96.3 bits (238), Expect = 2e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 215 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 269
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 330 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 389
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 390 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212
Query: 570 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 616
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 617 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 671
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 672 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 728
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 729 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 784
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480
Query: 845 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 888
A A A+ E + L +A E A +A E++ T E
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 948
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594
Query: 949 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 1005
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 1006 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1062
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 1063 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 1121
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 1122 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1175
+ +LS+E A QL +L + H ++ T
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 1176 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1213
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Score = 85.1 bits (209), Expect = 4e-16
Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 269
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205
Query: 330 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 371
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 372 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 533
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 534 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 585
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498
Query: 586 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 645
L L K EL R K E+ + S + +
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 705
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587
Query: 706 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 765
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 766 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 823
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 824 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 883
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 884 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 943
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815
Query: 944 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 987
K + + T+ I +L++ ++ + E A L +KKL A+
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 988 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 1044
E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ +
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1934
Query: 1045 IEGLRGPPP 1053
LRGPPP
Sbjct: 1935 ---LRGPPP 1940
Score = 81.3 bits (199), Expect = 6e-15
Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 338
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744
Query: 339 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 398
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800
Query: 399 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 514 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551
+K ++ + N + + A + + PPP+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1941
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 230 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 288
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 289 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 348
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940
Query: 349 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 408
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 409 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 456
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059
Query: 457 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112
Query: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 570
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 571 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 630
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213
Query: 631 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
EL+E + + + A L L +L EH + V +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270
Query: 687 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 741
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 742 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 785
+Q K S L + E L+ L EA +D L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 786 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 845
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437
Query: 846 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 904
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546
Query: 965 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1023
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 1024 DQLEAE-KAELKQR-LNSQSKRTIEG 1047
+ E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 258
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 318
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 319 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 378
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 379 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 439 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 485
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 605
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650
Query: 606 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 716
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 717 VEPLTKAIK 725
+E ++ ++
Sbjct: 1759 MEAMSDRVR 1767
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 206 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 265
A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1903
Query: 266 QEQQADLQRRLKEARKEAKEAL 287
+ LQR L EA E+ EA+
Sbjct: 1904 NANRRKLQRELDEA-TESNEAM 1924
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 96.3 bits (238), Expect = 2e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 215 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 269
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 330 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 389
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 390 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205
Query: 570 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 616
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 617 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 671
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 672 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 728
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 729 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 784
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473
Query: 845 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 888
A A A+ E + L +A E A +A E++ T E
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 948
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587
Query: 949 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 1005
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 1006 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1062
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 1063 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 1121
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 1122 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1175
+ +LS+E A QL +L + H ++ T
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 1176 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1213
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Score = 85.1 bits (209), Expect = 4e-16
Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 269
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198
Query: 330 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 371
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 372 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 431
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 432 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 533
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 534 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 585
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491
Query: 586 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 645
L L K EL R K E+ + S + +
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 705
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580
Query: 706 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 765
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 766 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 823
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 824 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 883
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 884 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 943
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808
Query: 944 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 987
K + + T+ I +L++ ++ + E A L +KKL A+
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 988 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 1044
E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ +
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1927
Query: 1045 IEGLRGPPP 1053
LRGPPP
Sbjct: 1928 ---LRGPPP 1933
Score = 81.3 bits (199), Expect = 6e-15
Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 338
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737
Query: 339 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 398
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793
Query: 399 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847
Query: 454 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 513
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 514 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551
+K ++ + N + + A + + PPP+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1934
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 230 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 288
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 289 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 348
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933
Query: 349 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 408
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 409 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 456
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052
Query: 457 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105
Query: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 570
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 571 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 630
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206
Query: 631 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 686
EL+E + + + A L L +L EH + V +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263
Query: 687 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 741
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 742 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 785
+Q K S L + E L+ L EA +D L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 786 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 845
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430
Query: 846 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 904
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539
Query: 965 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1023
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 1024 DQLEAE-KAELKQR-LNSQSKRTIEG 1047
+ E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 258
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 318
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 319 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 378
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 379 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 439 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 485
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 605
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643
Query: 606 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 662
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 663 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 716
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 717 VEPLTKAIK 725
+E ++ ++
Sbjct: 1752 MEAMSDRVR 1760
Score = 33.5 bits (75), Expect = 1.3
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 206 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 265
A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1896
Query: 266 QEQQADLQRRLKEARKEAKEAL 287
+ LQR L EA E+ EA+
Sbjct: 1897 NANRRKLQRELDEA-TESNEAM 1917
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 94.7 bits (234), Expect = 5e-19
Identities = 176/853 (20%), Positives = 340/853 (39%), Gaps = 153/853 (17%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQA 270
K+ L +Q+ +L+E LE+ R R + + + + ELE K +LE + + QE ++
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 271 DLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALK 329
++ + +K +E + E ++EM + A+E E + +L++ + L+
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 330 ERVDELTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDAL--------VRMR 378
EL ++++L K + E K A +L+ + R++ L V +
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 379 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 438
+++ Q K KL + + ++ +E LQEE Q S +LK+ D E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
+E + NLE+++ L V D++ E + E A E + +L++ L+ R
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR--- 1400
Query: 499 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS--VERQQ----QPPPET 552
+E VA Y + K +L L D+ +L +Q++++ +E++Q Q E
Sbjct: 1401 -------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 553 FDFKIKFAETK--AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL 610
K+AE + A A+A E E + + +A+A
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARA----------------------------- 1484
Query: 611 LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRY 670
L + KAEL R Q + E+ + S + + + E L +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE------------------LEKS 1526
Query: 671 EHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHL 730
+ AL Q ++ ++ L E+ A E D + +E +A+K
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATE---------------DAKLRLEVNLQAMKAQFER 1571
Query: 731 YSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS 790
EQ E+ QL ++ ++ L+ + + R+ ++ ++ L +DLE
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELE----DERKQRSMAVAARKKLEMDL--KDLEAH 1625
Query: 791 CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQ 850
+ + +++ A + DC + L A +E+ A A +
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQ---------------MKDCMRELDDTRASREEILAQAKE 1670
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 910
L E ++ EELA A+E+ E + N + K A A++E
Sbjct: 1671 NEKKLKSMEAEMIQLQEELA--AAERAKRQAQQERDELADEIAN----SSGKGALALEEK 1724
Query: 911 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 970
+E R A L E+ + +G + DR L +AN
Sbjct: 1725 R-----------RLEARIAQLEEELEEEQGNTELINDR-----------------LKKAN 1756
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA-LQADIDQLEAE 1029
+++ + L+ A ++ E + +LE L+ K +E E T+ + +A I LEA+
Sbjct: 1757 LQIDQINTDLNLERSHA-QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 1030 KAELKQRLNSQSK 1042
A+L+++L++++K
Sbjct: 1816 IAQLEEQLDNETK 1828
Score = 91.3 bits (225), Expect = 5e-18
Identities = 245/1120 (21%), Positives = 459/1120 (40%), Gaps = 158/1120 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQ 266
V PL S++EE + A+ EE+L +R K+ + +L E+E + QL K+Q
Sbjct: 834 VKPLLQVSRQEEEMMAK----EEELVKVREKQLAAENRLTEMETLQSQL-----MAEKLQ 884
Query: 267 -EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 325
++Q + L +E + L AK++ +EE+ +A E EER + LQ E
Sbjct: 885 LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA------RVEEEEERCQHLQAEK 938
Query: 326 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 375
+ +++ + EL LE ++ ++ + + +LK+LEE+ L+D
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 376 -RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 434
R+ + +++ +E K + L + KN+ ++ ERL+ E Q +
Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE------------- 1045
Query: 435 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 494
E+ L + +L +++ EL+ + +L+ +E + A E Q +MA
Sbjct: 1046 -LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 495 RVREAQKRVEAAQETV----ADYQQTIKKYRQLTAHLQDVNRELTN-------QQEASVE 543
++RE + ++ QE + A + K+ R L L+ + EL + QQE +
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 544 RQQQPP--PETFDFKIKFAET------KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 595
R+Q+ +T + + K E + H++A+E Q+E Q R + L
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE--QTKRVKANLEKAKQTL 1222
Query: 596 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAG 655
G + V VLL K + K+ + + +L E L+ E
Sbjct: 1223 ENERGELANEVKVLLQ-----GKGDSEHKRKKVEAQLQE-------LQVKFNEGERVRTE 1270
Query: 656 LVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETV 715
L ++ LQ L LSQ K L + SA E L ELL ++ + +
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSD----SKSSKLTKDFSALESQLQDTQELLQEEN-RQKL 1325
Query: 716 NVEPLTKAIKYYQHLYSIHLAEQPE----------DCTMQLADHIKFTQSALDCMSV--E 763
++ K ++ ++ + L E+ E Q+AD K + ++ C+ E
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 764 VGR-LRAFLQGGQEATDIALLLRD-LETSCSDIRQFCKKIRRRMPGTDAPGIPAA-LAFG 820
V R L+ L+G + + + D LE + + ++Q ++ + D A L
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442
Query: 821 PQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGL-LVAALEE-LAFKASEQIY 878
+ D LL K ++ A ++ A A A+ E + L L ALEE + KA +
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKAELERL 1498
Query: 879 GTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELRA---AALRA 933
+ E L S + + ++++L + + E E ++ + EL+A A LR
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 934 EIT----------DAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL---LEKKL 980
E+ D +G + E+++ K+L + ++ EL + + S+ KKL
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKK---KQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Query: 981 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETM---DALQADIDQLEAEKAELKQRL 1037
+ KD + I+ +E LRK + + ++ M D +A +++ A+ E +++L
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675
Query: 1038 NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQI 1097
S I+ +A +Q+R + + S G G L L++
Sbjct: 1676 KSMEAEMIQ-----LQEELAAAERAKRQAQQERDELADEIANS-SGKG-----ALALEEK 1724
Query: 1098 SAMRLHISQLQHE------NSILKGAQMKASLASLPPLHV---AKLSHEGPGSELPAGAL 1148
+ I+QL+ E N+ L ++K + + ++ + SH +E L
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH-AQKNENARQQL 1783
Query: 1149 YRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQV--------AQLKSLSDTVE 1200
R+ +L L ++ T + A ++ AQL EQ+ A K + T +
Sbjct: 1784 ERQNKELKVKLQEME-GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 1201 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQD 1240
KLKD VL + +R A D A S+ + K + ++
Sbjct: 1843 KLKD-VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881
Score = 75.1 bits (183), Expect = 4e-13
Identities = 96/365 (26%), Positives = 170/365 (46%), Gaps = 51/365 (13%)
Query: 198 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE- 256
T L+ A+ E E L Q R ++E L + + + ELEK K LE
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 257 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
QV+E K++++E + +LQ A ++AK LE + M+ + ++ D++ E+
Sbjct: 1533 QVEEMKTQLEELEDELQ-----ATEDAKLRLEVNLQAMKAQFER----DLQGRDEQSEEK 1583
Query: 317 RAESLQQEVEALKERVDE-------------LTTDLEILKAEIE--EKGSDGAASSYQLK 361
+ + ++Q E E DE L DL+ L+A I+ K D A +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA-----IK 1638
Query: 362 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 421
QL + A++KD + + D +S ++E + K EKK + +E + +LQEEL+ AE
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRAS-REEILAQAKENEKKLKSMEA---EMIQLQEELAAAER 1694
Query: 422 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 481
+ +++ D A+E+ L LEEK R L + LE +EL+E T
Sbjct: 1695 AKRQAQQERDEL--ADEIANSSGKGALALEEK-RRLEARIAQLE------EELEEEQGNT 1745
Query: 482 ELELREQLDMAGARVREAQKRVEA----AQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 537
EL + ++L A ++ + + AQ+ QQ ++ ++L LQ++ + ++
Sbjct: 1746 EL-INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 538 QEASV 542
+AS+
Sbjct: 1805 YKASI 1809
Score = 75.1 bits (183), Expect = 4e-13
Identities = 93/352 (26%), Positives = 171/352 (48%), Gaps = 47/352 (13%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKA-------KLKELEKH-----KIQLEQVQEWK 262
++++ L QVR++E +LE R +R+ A LK+LE H K + E +++ +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 263 SKMQEQQADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKEM-AEERAES 320
K+Q Q D R L + R +E L +AKE E+ + +A EM L +E+ A ERA+
Sbjct: 1642 -KLQAQMKDCMRELDDTRASREEILAQAKEN--EKKLKSMEA-EMIQLQEELAAAERAK- 1696
Query: 321 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQ-------NARLKDA 373
+Q + E DE+ +EEK A + ++LEE+ N RLK A
Sbjct: 1697 -RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 374 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 433
+++ +++ E QK E Q+LE +Q + L+ +L + E T+ + A
Sbjct: 1756 NLQIDQINTDLNLERSHAQK-NENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 434 LGAE--EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
L A+ ++ E L + + +++R T L+ + D+ + NA + ++Q D
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE----QYKDQADK 1867
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD-------VNRELTN 536
A R+++ ++++E A+E + Q+ R+L L+D +NRE+++
Sbjct: 1868 ASTRLKQLKRQLEEAEE---EAQRANASRRKLQRELEDATETADAMNREVSS 1916
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/299 (21%), Positives = 128/299 (42%), Gaps = 40/299 (13%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
K+ L+AQ++D +L+ R R E A+ KE EK M+ + LQ
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----------KSMEAEMIQLQE 1687
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA------- 327
L A + ++A + ++ +E+A+++ +A +K E R L++E+E
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
+ +R+ + ++ + ++ + S + +QLE QN LK L M S+ +
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 388 HV--------KLQKLMEKKNQELEV----VRQQRERLQEELSQAES---TIDELKEQVDA 432
+ +L++ ++ + +E + VR+ ++L++ L Q + ++ K+Q D
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Query: 433 ALGA--------EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 483
A EE E N + + REL + +AMN L+ R +L
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 24/123 (19%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQ 269
L + +KE + QVR E+KL K L +++ + EQ ++ K +
Sbjct: 1823 LDNETKERQAACKQVRRTEKKL----------KDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 270 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 329
L+R+L+EA +EA+ A ++ + E+ D A E A+++ +EV +LK
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELED--------------ATETADAMNREVSSLK 1918
Query: 330 ERV 332
++
Sbjct: 1919 NKL 1921
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.7 bits (234), Expect = 5e-19
Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 264
+KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K +
Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 265 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 319
M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108
Query: 320 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 361
LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 362 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 414
+++ A + RDL + Q L +K ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 415 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 470
E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282
Query: 471 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 529
LQ + E +L E+ + R Q + +E ++ IK L LQ
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 530 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 580
+ + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401
Query: 581 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 636
A H+ + A E +++ Q + E
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437
Query: 637 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 693
ER AA +Q +F L + T HA + S + +G+ L+ +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492
Query: 694 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 749
A+E SLD L E L ++ + + LT+ I K L I + E C +Q A
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549
Query: 750 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 808
+ A + E G+ LR L+ Q +++ + + + +++ +I M T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 809 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 868
+ A + L + L AA+ + +G+L
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 869 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 926
L A ++ E + + + N+L + + +L +++ E + +
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 927 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 978
R L + T KLE + E +++E + + + + +++A + L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 979 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 1032
+ D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827
Query: 1033 LKQRLNSQSKRTIEGLRG 1050
L+ + S+ KR E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845
Score = 89.4 bits (220), Expect = 2e-17
Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
+++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
L + +K EI++ S+ S LE+ L+D L +L S E+++ + L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279
Query: 395 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 444
++ ++ E ++E L +LS+ + I+ELK Q++ + A+ +
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 445 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 492
+ + L E+ E +E+ +L+ A+++ N E+ + +A + EL E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 493 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 552
R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458
Query: 553 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 605
++K K ET A +A + E R + ++ A + L ++ D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 606 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 663
+ + I + E I+KQ QEK EL E L G+ L L S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 664 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 717
+ + + Q + + V S+ + A RS + I L K ++++ +N
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638
Query: 718 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 767
+A++ Y++ I HL + ED QLA + + + E+ L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694
Query: 768 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 827
RA L+ + + IA E D + + + + + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729
Query: 828 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 887
++ +K L ++ +Q ++ E A+ + A A E +S+ E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 888 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 944
++++ T+ L + E E A + K +E R L E+ + +
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 945 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 1002
L E +KE L + EE + +RL L KL + K + E+ + +
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1003 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
A RK + E EE + +ADI + + K +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931
Score = 88.6 bits (218), Expect = 4e-17
Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 258
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 313
+ K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 314 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 360
++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 361 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 398
++LEE + RL++A + M RDL + Q L +K
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 399 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 451
++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 452 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 511
K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 512 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 561
++ IK L LQ + + +QE+ E Q+ + E ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382
Query: 562 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 614
T A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 615 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 665
C A +++ +K E + C E L + E S L Y SL Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 666 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 715
TL R L Q D+ +++ + ++ + L +E E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 716 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 769
+ + + + +AE+ E+ +HI+ +S + E+ RL+
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 828
++G L ++E + + + R T GI + D L
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669
Query: 829 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 886
D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
+ L LI+T KL T + + + + E + E +A + ITDA + +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776
Query: 947 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 995
+ L++ K + + + +RL E+ KL++ ++ + +E Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 996 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 1044
R E LRK E+ +E + D +D+L+A+ K++ +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Score = 82.0 bits (201), Expect = 3e-15
Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)
Query: 236 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 295
LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E
Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 296 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 341
+AD + I++ KE+ E E E + E+ A K +++ EL D++
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 342 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 401
L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012
Query: 402 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 460
L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 461 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 517
+ D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 518 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 577
+ R A + +L+ + E ER ++ T + K + R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185
Query: 578 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 635
A Q + L DS G D + + K +L +++++ K E+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237
Query: 636 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 695
S + A G L LS L++ + ++ D+ + G L E
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293
Query: 696 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 755
R LD ++ V L++ + + +Q E+ QL + IK +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334
Query: 756 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 812
AL + LR + QE+ A L R L + +++ Q+ K TDA
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385
Query: 813 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 872
Q ++ L + +K L + +E A A L + + L +E+L
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 873 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 932
E +C L + E + E ++ + A +L
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 933 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 992
E+ + + D+ +K K+L+ + +L+E +L+ K ++
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 993 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 1050 GPPPSGIATLVSGIAGEEQQRG 1071
+ I + I +++ G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626
Score = 82.0 bits (201), Expect = 3e-15
Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)
Query: 222 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 267
A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E
Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933
Query: 268 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 327
+ ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 388 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 438
+ L++ K +L++ + ++++L E+L + E I L+ ++ + ALG
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
+ L++K++EL+ + +LE E + A + +L +L+ R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 499 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 554
A ++E ++ A++Q+ + + T + L + SV +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 555 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 609
K K + K+ K ME+ + V++A ++ + + D
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262
Query: 610 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 665
+EL K+ +++ +++ ++R L+ +GE QL LV LS QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 666 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 723
+ E Q ++ K +L + + D L E ++Q + L+KA
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 724 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 779
+ ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430
Query: 780 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 839
+ L+ D+E + + KK R F +++ C + + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475
Query: 840 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 899
+E + +L + A EE S E L++ L
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514
Query: 900 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 959
++ L + EG VE L+A + +AE LE E I ++ L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571
Query: 960 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 1019
+ SE + +++ ++++D ++ +E +Q+ L + E DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618
Query: 1020 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
+ ++E + E++ +LN ++ E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)
Query: 221 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 273
R +R +E TL ++ D +LK +L + +IQL ++ + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
LK+ + +AL ++E E++A M E RA LQ E+E L+ ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
+ +I + E+ + +S +++ L QN L +++K+ + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 449
+ + L+ R E+ ++ ++ A +ELK++ D + E M + + D L
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 450 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 494
L+E + +RE G++E+ + N E + R+ E ++E
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858
Query: 495 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 547
+ E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Query: 548 PPPETFDFKIKFAETKAHAKAIEME 572
+ ++K E H K I E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941
Score = 54.7 bits (130), Expect = 6e-07
Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719
Query: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 324
+ + + K++ +++ +E + AEE+ AE L++E
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 325 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 379
+E +K+ +++ DL++ E E+ G KQ+++ AR+++ +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830
Query: 380 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 439
SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Query: 440 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 487
E ++ NL K R+L+ +LE E D + + ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 261
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 262 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 317 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 370
++++Q V+ L+ R+DE +I K E + +G S Q + E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 371 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 423
K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 424 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 454
EL+E + A AE V L ++ + KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 41.2 bits (95), Expect = 0.006
Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 262
L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 263 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 322
++Q+ LQ ++K +++A+EA E + + +E A EERA+ +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920
Query: 323 QEVEALKERVDELTT 337
+V L+ + E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.7 bits (234), Expect = 5e-19
Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 264
+KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K +
Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 265 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 319
M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108
Query: 320 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 361
LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 362 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 414
+++ A + RDL + Q L +K ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 415 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 470
E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282
Query: 471 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 529
LQ + E +L E+ + R Q + +E ++ IK L LQ
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 530 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 580
+ + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401
Query: 581 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 636
A H+ + A E +++ Q + E
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437
Query: 637 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 693
ER AA +Q +F L + T HA + S + +G+ L+ +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492
Query: 694 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 749
A+E SLD L E L ++ + + LT+ I K L I + E C +Q A
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549
Query: 750 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 808
+ A + E G+ LR L+ Q +++ + + + +++ +I M T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 809 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 868
+ A + L + L AA+ + +G+L
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 869 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 926
L A ++ E + + + N+L + + +L +++ E + +
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 927 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 978
R L + T KLE + E +++E + + + + +++A + L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 979 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 1032
+ D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827
Query: 1033 LKQRLNSQSKRTIEGLRG 1050
L+ + S+ KR E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845
Score = 89.4 bits (220), Expect = 2e-17
Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
+++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
L + +K EI++ S+ S LE+ L+D L +L S E+++ + L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279
Query: 395 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 444
++ ++ E ++E L +LS+ + I+ELK Q++ + A+ +
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 445 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 492
+ + L E+ E +E+ +L+ A+++ N E+ + +A + EL E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 493 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 552
R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458
Query: 553 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 605
++K K ET A +A + E R + ++ A + L ++ D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 606 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 663
+ + I + E I+KQ QEK EL E L G+ L L S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 664 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 717
+ + + Q + + V S+ + A RS + I L K ++++ +N
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638
Query: 718 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 767
+A++ Y++ I HL + ED QLA + + + E+ L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694
Query: 768 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 827
RA L+ + + IA E D + + + + + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729
Query: 828 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 887
++ +K L ++ +Q ++ E A+ + A A E +S+ E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 888 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 944
++++ T+ L + E E A + K +E R L E+ + +
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 945 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 1002
L E +KE L + EE + +RL L KL + K + E+ + +
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1003 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
A RK + E EE + +ADI + + K +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931
Score = 88.6 bits (218), Expect = 4e-17
Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 258
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 259 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 313
+ K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 314 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 360
++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 361 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 398
++LEE + RL++A + M RDL + Q L +K
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 399 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 451
++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 452 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 511
K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 512 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 561
++ IK L LQ + + +QE+ E Q+ + E ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382
Query: 562 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 614
T A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 615 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 665
C A +++ +K E + C E L + E S L Y SL Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 666 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 715
TL R L Q D+ +++ + ++ + L +E E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 716 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 769
+ + + + +AE+ E+ +HI+ +S + E+ RL+
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 828
++G L ++E + + + R T GI + D L
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669
Query: 829 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 886
D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
+ L LI+T KL T + + + + E + E +A + ITDA + +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776
Query: 947 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 995
+ L++ K + + + +RL E+ KL++ ++ + +E Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 996 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 1044
R E LRK E+ +E + D +D+L+A+ K++ +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Score = 82.0 bits (201), Expect = 3e-15
Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)
Query: 236 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 295
LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E
Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 296 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 341
+AD + I++ KE+ E E E + E+ A K +++ EL D++
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 342 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 401
L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012
Query: 402 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 460
L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 461 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 517
+ D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 518 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 577
+ R A + +L+ + E ER ++ T + K + R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185
Query: 578 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 635
A Q + L DS G D + + K +L +++++ K E+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237
Query: 636 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 695
S + A G L LS L++ + ++ D+ + G L E
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293
Query: 696 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 755
R LD ++ V L++ + + +Q E+ QL + IK +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334
Query: 756 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 812
AL + LR + QE+ A L R L + +++ Q+ K TDA
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385
Query: 813 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 872
Q ++ L + +K L + +E A A L + + L +E+L
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 873 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 932
E +C L + E + E ++ + A +L
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 933 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 992
E+ + + D+ +K K+L+ + +L+E +L+ K ++
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 993 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 1050 GPPPSGIATLVSGIAGEEQQRG 1071
+ I + I +++ G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626
Score = 82.0 bits (201), Expect = 3e-15
Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)
Query: 222 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 267
A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E
Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933
Query: 268 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 327
+ ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 388 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 438
+ L++ K +L++ + ++++L E+L + E I L+ ++ + ALG
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
+ L++K++EL+ + +LE E + A + +L +L+ R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 499 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 554
A ++E ++ A++Q+ + + T + L + SV +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 555 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 609
K K + K+ K ME+ + V++A ++ + + D
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262
Query: 610 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 665
+EL K+ +++ +++ ++R L+ +GE QL LV LS QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 666 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 723
+ E Q ++ K +L + + D L E ++Q + L+KA
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 724 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 779
+ ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430
Query: 780 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 839
+ L+ D+E + + KK R F +++ C + + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475
Query: 840 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 899
+E + +L + A EE S E L++ L
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514
Query: 900 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 959
++ L + EG VE L+A + +AE LE E I ++ L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571
Query: 960 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 1019
+ SE + +++ ++++D ++ +E +Q+ L + E DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618
Query: 1020 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
+ ++E + E++ +LN ++ E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)
Query: 221 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 273
R +R +E TL ++ D +LK +L + +IQL ++ + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
LK+ + +AL ++E E++A M E RA LQ E+E L+ ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
+ +I + E+ + +S +++ L QN L +++K+ + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 449
+ + L+ R E+ ++ ++ A +ELK++ D + E M + + D L
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 450 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 494
L+E + +RE G++E+ + N E + R+ E ++E
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858
Query: 495 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 547
+ E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Query: 548 PPPETFDFKIKFAETKAHAKAIEME 572
+ ++K E H K I E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941
Score = 54.7 bits (130), Expect = 6e-07
Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719
Query: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 324
+ + + K++ +++ +E + AEE+ AE L++E
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 325 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 379
+E +K+ +++ DL++ E E+ G KQ+++ AR+++ +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830
Query: 380 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 439
SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Query: 440 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 487
E ++ NL K R+L+ +LE E D + + ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 261
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 262 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 317 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 370
++++Q V+ L+ R+DE +I K E + +G S Q + E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 371 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 423
K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 424 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 454
EL+E + A AE V L ++ + KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 41.2 bits (95), Expect = 0.006
Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 262
L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 263 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 322
++Q+ LQ ++K +++A+EA E + + +E A EERA+ +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920
Query: 323 QEVEALKERVDELTT 337
+V L+ + E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.4 bits (233), Expect = 6e-19
Identities = 178/905 (19%), Positives = 370/905 (40%), Gaps = 131/905 (14%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLETL-----RLKRAEDKAKLKELEKHKIQLEQVQEW 261
+ PL ++ E+ + D E E L R K E+K EK+ +QL+ E
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899
Query: 262 KSKMQEQQA----------------DLQRRLKEARKEAKEALEAKERYMEEMADTA---- 301
++ M ++ +L RL+E +E L AK+R +E+ +
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEE-EEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 302 DAIEMATL----DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 357
D +E+ +K E + ++L +E+ AL+E + +LT + + L+ ++ D
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 358 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-------VRQQRE 410
++ L + NA+L+ + EK+ L++ K +L++ + ++
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 411 RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 470
+++E+L + E + +L+ ++D +E V +L ++K++EL+ + +LE E
Sbjct: 1079 QIEEKLKKKEFELSQLQAKID-----DEQV-----HSLQFQKKIKELQARIEELEEEIEA 1128
Query: 471 NDELQENARETELELREQLDMAGARVREA----QKRVEAAQETVADYQQTIKKYRQLTAH 526
L+ + +L +L+ R+ EA ++E ++ A++Q+ + + T
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 527 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 586
+ L +Q SV + K K + K+ K ME+ ++
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK--------MEIDDMASNIE 1240
Query: 587 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAA 646
L S + + C V + K E +Q Q +L+ + G
Sbjct: 1241 AL------SKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIHDLNMQKARLQTQNGEL 1291
Query: 647 GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELL 706
++ L+ L+ + L + L + + K ++ + + D L E
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351
Query: 707 HKDQLDETVNVEPLTKA---IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALD-- 758
++Q + L+KA + ++ Y +I E+ E+ +LA ++ + +
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 759 ---CMSVEVGRLRAFLQGGQEATDIALLLRDLE---TSCSDI----RQFCKKI---RRRM 805
C S+E + R LQG ++ L+RDLE T+C+ + R F K + ++++
Sbjct: 1412 NSKCASLEKTKQR--LQG-----EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 806 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 865
+ A + AA +S L R VV L+ + EN+
Sbjct: 1465 DESQAE-LEAAQKESRSLSTELFKMRNAYEEVVDQLETLR----------RENKN----- 1508
Query: 866 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 925
L+E +EQI T + + ++ ++ + L A++E E E SK V+
Sbjct: 1509 LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566
Query: 926 LRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---EANVR----LSLLEK 978
L + +++E L K+ +++ I++LK++ + E L +A +R L+K
Sbjct: 1567 LELSQVKSE------LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620
Query: 979 KLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLN 1038
K++ + + ++ ++ ETQ LR + + +++ Q +D +LK++L
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS----QLHLDDALRSNEDLKEQLA 1676
Query: 1039 SQSKR 1043
+R
Sbjct: 1677 IVERR 1681
Score = 93.6 bits (231), Expect = 1e-18
Identities = 193/967 (19%), Positives = 398/967 (41%), Gaps = 165/967 (17%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLR---LKRAEDKAKLKELEKHKIQLEQVQEWK---- 262
L KE+ +V++L E++ L K ++K L+E + + QV+E K
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 263 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-------------- 304
+K+++Q DL+ L++ +K + AK + ++ + ++I
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084
Query: 305 -----EMATLDKEMAEERAESLQ--QEVEALKERVDELTTDLEI---LKAEIEEKGSDGA 354
E++ L ++ +E+ SLQ ++++ L+ R++EL ++E L+A+IE++ SD A
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144
Query: 355 ASSYQLKQLEEQNARLKDALVRM------------RDLSSSEKQEHVKLQKLMEKKNQEL 402
++ + E+ + A + M RDL + Q L +K+ +
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204
Query: 403 EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 462
+ +Q + LQ + E ELK ++D +E L+ N+E R + +
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEID---DMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 463 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR- 521
+++A +E +L + + L+ Q RV E + + ++ Q +++ +
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321
Query: 522 ----------------QLTAHLQDVNRE-LTNQQEASVERQQ---QPPPETFDFKIKFAE 561
Q + H D+ RE +QEA E Q+ + E ++ K+ E
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY-E 1380
Query: 562 TKAHAKAIEMELRQMEVAQANRHMSLLT-------AFMPDSFLRPGGDHDCVLVLLLMPR 614
T A + E+E + ++AQ + T A + + R G+ + ++ L
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 615 LICKAELIRKQ-------AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATL 667
C A L +KQ A+ K +L E+ +E L A E S + L + + +
Sbjct: 1441 TAC-ATLDKKQRNFDKVLAEWKQKLDESQAE---LEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 668 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSL---DFLIELLHKDQLDETVNVEPLTKAI 724
+ E L + + ++ +++ L +++ ++L + +L+ +++ D V +E + ++
Sbjct: 1497 DQLE-TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 725 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALL 783
++ E+ + +QL + +S LD +E + + Q A +
Sbjct: 1556 EH----------EESKILRVQL--ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 784 LRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQE 843
+ D E R +++++M G D + L + + + +KHL V L++
Sbjct: 1604 VLDAEIRS---RNDALRLKKKMEG-DLNEMEIQLGHSNR---QMAETQKHLRTVQGQLKD 1656
Query: 844 VAAAA----------AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC 893
+ +A + GLL+ LEE+ A EQ T S E L S
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV-ALEQTERTRRLSEQELLDASD 1715
Query: 894 NI---------LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLK 944
+ LI+T KL + + + + E + E +A + ITDA + +
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKA---KKAITDAAMMAEE 1772
Query: 945 L---EDRETVIKELKKSLK-----------------IKG--EELSEANVRLSLLEKKLDS 982
L +D ++ +KK+L+ +KG +++ + R+ LE +LD
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 983 AAKDADERIE---KVQTRLEETQALLRKKEKEF---EETMDALQADIDQLEAEKAELKQR 1036
K E ++ K + +++E + K ++ +D LQA + + + E +++
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 1037 LNSQSKR 1043
N+Q R
Sbjct: 1893 ANTQLSR 1899
Score = 56.6 bits (135), Expect = 1e-07
Identities = 69/326 (21%), Positives = 138/326 (42%), Gaps = 38/326 (11%)
Query: 226 DLEEKLETLRLKRAEDKAKLKELE----KHKIQLEQVQEWKSKMQEQQADLQRRLKEA-- 279
++ + + LRLK+ + L E+E Q+ + Q+ +Q Q D Q L +A
Sbjct: 1608 EIRSRNDALRLKKKME-GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 280 -RKEAKEALEAKER----YMEEMADTADAIEMATLDKEMAE-------ERAESLQQEVEA 327
++ KE L ER +EE+ + A+E + ++E +R + L + +
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
L +L D+ +AE+E + + + K+ A + + L + +D S+ ++
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 388 HVKLQKLMEKKNQELEVVRQ--------QRERLQEELSQAESTID-ELKEQVDAALGAEE 438
L++ ++ L+ Q Q ++L+ + + E+ +D E K +A GA +
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846
Query: 439 MVEMLTDRNLNLEE---KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGAR 495
+ + EE + L++ V L+A +++ R+ E E EQ + +R
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQA------KVKSYKRQAE-EAEEQANTQLSR 1899
Query: 496 VREAQKRVEAAQETVADYQQTIKKYR 521
R Q +E A E + + K R
Sbjct: 1900 CRRVQHELEEAAERADIAESQVNKLR 1925
Score = 55.8 bits (133), Expect = 3e-07
Identities = 55/275 (20%), Positives = 123/275 (44%), Gaps = 44/275 (16%)
Query: 224 VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEA 283
+R E+ E L + + L+ELE+ K+ LEQ + + +++ D R++ +
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 284 KEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE------VE 326
+ K++ ++A +E + + AEE+ AE L++E +E
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL------------ 374
+K+ +++ DL+ E E+ G Q+++LE + L++ L
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKK--QIQKLENRVRELENELDVEQKRGAEALK 1842
Query: 375 ------VRMRDLSSSEKQEH---VKLQKLMEKKNQELEVVRQQRERLQE----ELSQAES 421
++++++ +++H ++LQ L++K +++ ++Q E +E +LS+
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902
Query: 422 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE 456
EL+E + A AE V L ++ ++ + E
Sbjct: 1903 VQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 36.6 bits (83), Expect = 0.16
Identities = 34/156 (21%), Positives = 71/156 (45%), Gaps = 49/156 (31%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLL----------EKKLDS----------- 982
+LE+ + +++ +++ ++ +EL +A+ R+ LL +KKL++
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 983 ---AAKDADERIEKVQT----------RLEETQALLRKKEKEFEETMDALQADIDQ---- 1025
+++A+E+ +K T + ++T A L + +K E+T+ LQ +D+
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 1026 -----------LEAEKAELKQRLNSQSKRTIEGLRG 1050
LE EL+ L+ + KR E L+G
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843
Score = 32.7 bits (73), Expect = 2.3
Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 3/103 (2%)
Query: 947 DRETVIKELKKSLKIKGEELSEANVRLS---LLEKKLDSAAKDADERIEKVQTRLEETQA 1003
D E +++++ LK K ELS+ ++ + + K+ RIE+++ +E
Sbjct: 1072 DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
Query: 1004 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1046
L K EK+ + L+ ++LE ++ KR E
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 94.0 bits (232), Expect = 8e-19
Identities = 99/400 (24%), Positives = 192/400 (48%), Gaps = 48/400 (12%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQ 268
L ++++ L +++R LEE+ +L+ ++ E++ K LEK + L+ Q+ + K K+ +
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 269 QADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMA--TLDKEMAE-----ERAESL 321
++ L+EA+K+ + EA + +EE A D +E L +E+ + + +
Sbjct: 1384 LGTIE-SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 322 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR-LKDALVRMRDL 380
+E +++ D+L + + + A E+ A + + + AR L++AL +
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502
Query: 381 SSSEKQEHVKLQKLMEKKN------QELEVVRQQRERLQEEL-SQAESTIDELKEQVDAA 433
KQ ++ LM K+ ELE ++ E+ EE+ +Q E DEL+ DA
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 434 LGAEEMVEM--------LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 485
L E ++ L R+ EEK R L + V +LEA E+ DE ++ A +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA--ELEDERKQRALAVASKK 1620
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
+ ++D+ ++ + ++EAA + + IK+ R+L A ++D REL +EA R
Sbjct: 1621 KMEIDL-----KDLEAQIEAANKA---RDEVIKQLRKLQAQMKDYQREL---EEARASRD 1669
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANR 583
+ + E++ K++E E+ Q+ E+A + R
Sbjct: 1670 --------EIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Score = 93.6 bits (231), Expect = 1e-18
Identities = 177/882 (20%), Positives = 353/882 (40%), Gaps = 148/882 (16%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
L+AQ+ +L+E E+ + R + + + + ELE K +LE + + QE + ++
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 276 LKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
+ E +K +E + E +++M A A+E + E A+ +L++ + L+ E
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 335 LTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 391
L ++++L KAE E K A +L + RL+ L ++ KL
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA----------EKASKL 1285
Query: 392 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 451
Q ++ + LE ++ + ++ + ES + + +E+++ T + LNL
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD----------TQELLQEETRQKLNLS 1335
Query: 452 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV----------REAQK 501
++R+L E L+ E +E ++N + L L+ QL +V EA+K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 502 RV--------EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE--ASVERQQ----Q 547
++ + +E Y + K +L L D+ +L +Q++ +++E++Q Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 548 PPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 605
E ++AE +A A+A E E + + +A+A
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARA------------------------ 1491
Query: 606 VLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQA 665
L L K E R+ Q + ++ + S + + E L + ++
Sbjct: 1492 -----LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 666 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIK 725
L E L Q + D L E++ F +L +D+ +E E IK
Sbjct: 1547 QLEELEDEL-QATED-----AKLRLEVNMQAMKAQFERDLQTRDEQNE----EKKRLLIK 1596
Query: 726 YYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLL 784
+ L L ++ + + +A K M +++ L A ++ +A D + L
Sbjct: 1597 QVREL-EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 785 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 844
R L+ D ++ ++ R A ++ + K L+ +
Sbjct: 1648 RKLQAQMKDYQRELEEAR---------------ASRDEIFAQSKESEKK-------LKSL 1685
Query: 845 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLA 904
A QL LA +E A +E A E T S+S L L + + +L
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEI---TNSASGKSALLDEKRRLEARIAQLE 1742
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
++E + + E + L+ L AE+ K ++ ++ K LK K +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 965 EL------------SEANVRLSLLEKKLDSAAKD---ADERIEKVQTRLEETQALL---R 1006
EL S ++ LE++L+ AK+ A++ + + + +L+E + R
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 1007 KKEKEFEETMDALQADIDQL--EAEKAELKQRLNSQSKRTIE 1046
+ +++E M+ A + QL + E+AE + + S+R ++
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Score = 90.9 bits (224), Expect = 7e-18
Identities = 215/1082 (19%), Positives = 426/1082 (39%), Gaps = 181/1082 (16%)
Query: 207 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-KHKIQLEQVQEWKSKM 265
V PL +++EE L+A+ +E+L ++ K+ + + +L+E+E KH+ LE+ +
Sbjct: 841 VKPLLQVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE-----KNI 891
Query: 266 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 325
+Q + L +E + L AK++ +EE+ ++ E EER + LQ E
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES------RVEEEEERNQILQNEK 945
Query: 326 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 375
+ ++ + +L L+ + ++ + + ++K++EE+ L+D
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 376 -RMRDLSSSEKQEHVKLQKLM--------------------EKKNQELEVVRQQRE---- 410
R+ + SS +E K + L EK QELE +++ +
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 411 RLQEELSQAESTIDELKEQV----DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 466
LQ+++++ ++ IDELK Q+ + GA + T N + VREL+ + +L+
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 467 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 526
E + A + + +L E+L+ + +E +T A Q+ K Q A
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELE-------ALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 527 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 586
L+ E T EA ++ +Q HA A+E Q+E QA R +
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQ----------------RHATALEELSEQLE--QAKRFKA 1220
Query: 587 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK-QAQEKFELSENCSERPGLRGA 645
L + G + D L C+ +++++ +A+ + + + ++ L
Sbjct: 1221 NLEK------NKQGLETD-------NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 646 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 705
E L S LQ L L + KK + ++ E L EL
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAE----KKGIKFAKDAASLESQLQDTQEL 1323
Query: 706 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 765
L +++ + +N+ + ++ ++ E+ E+ L + QS L +V
Sbjct: 1324 L-QEETRQKLNLSSRIRQLEEEKNSLQ-EQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 766 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFC------KKIRRRMPGTDAPGIPAALAF 819
++ +EA LL+D E + + +K + R+ + + L
Sbjct: 1382 DDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ-QELDDLTVDLDH 1438
Query: 820 GPQVSDTLLDCRKHLTWVVAVLQEVAAA------AAQLIAPLAENEGLLVAALEELAFKA 873
QV+ L +K ++A + ++A A+ A E + L +A E A +A
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 874 SEQIYGTPSSSPYEC----------------LRQSCNILISTMNKLATAMQEGEYDAERP 917
E+ + L +S L + ++ T ++E E + +
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 918 PSKPPPVELRAAALRAEI-TDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 976
+E+ A++A+ D + + E+++ ++ + + L+ + E+ +
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 977 EKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLEAEKAEL 1033
+KK++ KD + +IE +E LRK + K+++ ++ +A D++ A+ E
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 1034 KQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLL 1093
+++L S ++ +A+ EQ+R + + S G L
Sbjct: 1679 EKKLKSLEAEILQ-----LQEELASSERARRHAEQERDELADEITNSASG------KSAL 1727
Query: 1094 LQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTS 1153
L + + I+QL+ E L E EL +RKT+
Sbjct: 1728 LDEKRRLEARIAQLEEE-----------------------LEEEQSNMEL-LNDRFRKTT 1763
Query: 1154 QLLETLN-QLSTHTHVVDITRTSPAAKSPSA--QLMEQVAQLKSLSDTVEKLKDEVLKET 1210
++TLN +L+ S A KS +A QL Q +LK+ +E K T
Sbjct: 1764 LQVDTLNAELA--------AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815
Query: 1211 VS 1212
+S
Sbjct: 1816 IS 1817
Score = 85.9 bits (211), Expect = 2e-16
Identities = 185/977 (18%), Positives = 402/977 (41%), Gaps = 103/977 (10%)
Query: 216 EEEGLRAQVRDLEEKLET-------LRLKRAEDKAKLKELEKHKIQLEQVQ----EWKSK 264
E++ ++A ++DLEE+L+ L+L++ +AK+K++E+ + LE + K
Sbjct: 944 EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003
Query: 265 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 324
M+++ A+ +L E ++AK + + + ++D + ++ ++ E+ L E
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 325 VEALKERVDELTTDLEILKAEIEEKGSD--GAASSYQLKQLEEQNA-----RLKDALVRM 377
L++++ EL ++ LK ++ +K + GA + + L + NA L+ + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 378 RDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRE------RLQEEL-SQAESTIDELKEQV 430
++ SEK K +K ++ELE ++ + E Q+EL ++ E + ELK+ +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 431 DAAL-GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDE-LQENARETELELREQ 488
+ E ++ + R+ E++ E E +A E N + L+ + +E E++
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV- 1242
Query: 489 LDMAGARVREAQKRVEA-AQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 547
L A +K+++A QE A + + +L + EL N E +++
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302
Query: 548 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP-----DSFLRPGGD 602
IKFA+ A ++ + +++ + + ++L + +S +
Sbjct: 1303 G--------IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 603 HDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLS- 661
+ L L +++L A K ++ ++ L A + L A L L
Sbjct: 1355 EEEARKNLEKQVLALQSQL----ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 662 ------LLQATLHRYEHALSQCSVDV---------YKKVGSLYPEMSAHERSLDFLIELL 706
L+ T +R + L +VD+ +K + ++ A E+S I
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISAR 1466
Query: 707 HKDQLD--ETVNVEPLTKAIKYYQHLY-SIHLAEQPEDCTMQLADHIKFTQSALDCMSVE 763
+ ++ D E E TKA+ + L ++ E+ E QL ++ S+ D +
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 764 VGRLRAFLQG-GQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQ 822
V L + Q+ ++ L +LE D Q + + R+ + + A Q
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELE----DELQATEDAKLRLE-VNMQAMKAQFERDLQ 1581
Query: 823 VSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS 882
D + +K L ++++V A+L + L VA+ +++ +
Sbjct: 1582 TRDEQNEEKKRL-----LIKQVRELEAEL-EDERKQRALAVASKKKMEIDLKDL------ 1629
Query: 883 SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLG 942
+ E ++ + +I + KL M++ + + E + + ++ ++ E
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 943 LKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 1002
L+L++ + ++ + + +EL++ + + L + + RI +++ LEE Q
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 1003 ALLRKKEKEFEET---MDALQADI--DQLEAEKA----ELKQRLNSQSKRTIEGLRGPPP 1053
+ + F +T +D L A++ ++ A+K+ + +R N + K ++ L G
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Query: 1054 SGIATLVSGIAG-----EEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQL- 1107
S +S + EEQ +A + K + Q+ R H Q
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869
Query: 1108 -QHENSILKGAQMKASL 1123
Q E + + Q+K L
Sbjct: 1870 EQMEKANARMKQLKRQL 1886
Score = 78.2 bits (191), Expect = 5e-14
Identities = 85/345 (24%), Positives = 152/345 (44%), Gaps = 26/345 (7%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
K+ L+AQ++D + +LE R R E A+ KE EK +L+ ++ ++QE+ A +R
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK---KLKSLEAEILQLQEELASSER 1701
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA--EERAESLQQEVEALKERV 332
+ A +E E A E +A E L+ +A EE E Q +E L +R
Sbjct: 1702 ARRHAEQERDEL--ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK-L 391
+ T ++ L AE+ + S S +QLE QN LK L + S+ + + L
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 392 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV-DAALGAEEMVEMLTDRNLNL 450
+ + + ++LE ++R + + + E + E+ QV D A++ E + N +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 451 EEKVRELRETVGDLEAMNEMNDELQ---ENARETELELREQLDMAGARVREAQKRVEAAQ 507
++ R+L E + N +LQ ++A E L ++ R+R
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------ 1933
Query: 508 ETVADYQQTIKKYRQLTAHLQDVNRELTN---QQEASVERQQQPP 549
+ + RQL HL+ + EL++ + + S + QPP
Sbjct: 1934 ---ISFSSSRSGRRQL--HLEGASLELSDDDTESKTSDVNETQPP 1973
Score = 77.0 bits (188), Expect = 1e-13
Identities = 99/442 (22%), Positives = 191/442 (43%), Gaps = 87/442 (19%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQ 273
K L R LE+++E +R + E + +L+ E K++LE +Q K++ + DLQ
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQ 1581
Query: 274 RRLKEARKEAKEALEAKERYME-EMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 332
R E +E K L + R +E E+ D +A K+ E + L+ ++EA +
Sbjct: 1582 TR-DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 333 DELTTDLEILKAEI--------------EEKGSDGAASSYQLKQLEEQNARLKDALVRMR 378
DE+ L L+A++ +E + S +LK LE + +L++ L
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 379 DLSSSEKQEHVKL-----------QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 427
+QE +L L+++K + + Q E L+EE S E D +
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 428 E---QVD---AALGAEEMVEMLTD--------RNLNLEEKVREL--------RETVGDLE 465
+ QVD A L AE +D +N L+ K++EL + T+ LE
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 466 A-MNEMNDELQENARE----------TELEL-----------------REQLDMAGARVR 497
A + ++ ++L++ A+E TE +L +EQ++ A AR++
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 498 EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKI 557
+ ++++E A+E + +K ++ + N L+ + R ++ P I
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------I 1934
Query: 558 KFAETKAHAKAIEMELRQMEVA 579
F+ +++ + + +E +E++
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS 1956
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 93.6 bits (231), Expect = 1e-18
Identities = 184/884 (20%), Positives = 340/884 (38%), Gaps = 109/884 (12%)
Query: 211 PSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQA 270
PS E L + + E L ++ E + KEL+ K L+Q ++ + ++ Q
Sbjct: 387 PSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVM 446
Query: 271 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK- 329
+LQ +LK + AKE ++++ +T + +E K+ EE+ ++E+ ALK
Sbjct: 447 ELQNKLKHVQGPEP----AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKG 502
Query: 330 ---ERVDELTTDLEILKAEIEE------KGSDGAASSYQLKQLEEQNARLKDALVRMRDL 380
E V ++E ++ + + + A + + + E Q ALVR
Sbjct: 503 ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKM---SALVRGLQR 559
Query: 381 SSSEKQEHVKLQKLMEKKN--------QELEVVRQQRERLQEELSQAESTIDELKEQVDA 432
E E + M +KN QEL +R ++E ++EEL + + EQ A
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619
Query: 433 ALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELR-EQLDM 491
+ G VE+L L +E+++EL+ + E+ R+ ELE + L +
Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQ--------AERQSQEVAGRHRDRELEKQLAVLRV 671
Query: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551
R RE +++ Q+T+ +Q ++ + + + + Q+ A+VE + E
Sbjct: 672 EADRGRELEEQNLQLQKTLQQLRQDCEEASK-AKMVAEAEATVLGQRRAAVETTLRETQE 730
Query: 552 TFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLL 611
D E + +E +L++ L GG+ +
Sbjct: 731 END------EFRRRILGLEQQLKETR------------------GLVDGGE-------AV 759
Query: 612 MPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE----QLSFAAGLVYSLSLLQATL 667
RL K + + + Q+ E E G AA +L A + L Q TL
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 668 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 727
+R + + + L + +R++D L + L K D ++ L ++ Y
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 728 QHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDL 787
+ +A+ A + T L + E+ RLR LQ Q D A L ++L
Sbjct: 880 KEKARREVADAQRQ-AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938
Query: 788 ETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAA 847
+ +R+ G + + D K L V+ L+
Sbjct: 939 -------------LAQRLQGLEQEA-----ENKKRSQDDRARQLKGLEEKVSRLETELDE 980
Query: 848 AAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC---NILISTMNKLA 904
+ L + +++L +E + + EC + S N + T +
Sbjct: 981 EKNTVELLTDRVNRGRDQVDQL---RTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037
Query: 905 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 964
Q+ + S+ ++ R A E T + KLE + +KEL ++ + +
Sbjct: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK---VKELSIQIEDERQ 1094
Query: 965 ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADID 1024
+++ +LSL K L +A+E IE RL+ + +++ +E E + LQA I
Sbjct: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIE----RLDGLRKKAQREVEEQHEVNEQLQARIK 1150
Query: 1025 QLEAEKAELKQRLNSQSKRTIEGLRGP-------PPSGIATLVS 1061
LE + R ++S EGL PS IA+L++
Sbjct: 1151 SLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLT 1194
Score = 84.3 bits (207), Expect = 7e-16
Identities = 89/346 (25%), Positives = 159/346 (45%), Gaps = 44/346 (12%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK----HKIQLEQVQ----EW 261
L K+ E LR +LEE+ L R D+ KELEK K L+Q+Q ++
Sbjct: 823 LEEEGKQREVLRRGKAELEEQKRLL--DRTVDRLN-KELEKIGEDSKQALQQLQAQLEDY 879
Query: 262 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM-------ATLDKEMA 314
K K + + AD QR+ K+ EA++ R +E+ A++ A LDKE+
Sbjct: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939
Query: 315 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 374
+R + L+QE E K D+ L+ L+ ++ ++ ++ L ++ R +D +
Sbjct: 940 AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQV 999
Query: 375 VRMRDLSSSEK--QEHVKLQKL-MEKKNQELEVVRQQRERLQE---ELSQAESTIDELKE 428
++R E+ ++ ++ K+ +E++N++L+ E Q+ LSQ ES L+E
Sbjct: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059
Query: 429 QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQ 488
++ A E +L N LE KV+EL ++ DE Q + +Q
Sbjct: 1060 RLQAE---EREKTVLQSTNRKLERKVKELSI---------QIEDERQH--------VNDQ 1099
Query: 489 LDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL 534
D RV+ +++V+ A+E + KK ++ +VN +L
Sbjct: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
Score = 63.5 bits (153), Expect = 1e-09
Identities = 85/386 (22%), Positives = 169/386 (43%), Gaps = 65/386 (16%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLR-------LKRAEDKAKLKELEKHKIQLEQVQEWK 262
L +E + R ++ LE++L+ R A + KL+ LE K QLE+
Sbjct: 725 LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN-A 783
Query: 263 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 322
S+ +E +R EAR E EA R +E A+E +E+ L+
Sbjct: 784 SQEEEGSLAAAKRALEARLE--EAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841
Query: 323 QEVEALKERVDELTTDLE-----------ILKAEIEEK------------------GSDG 353
++ L VD L +LE L+A++E+ S+
Sbjct: 842 EQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEA 901
Query: 354 AASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK-LMEKKNQELEVVRQQRERL 412
+S L +L+++ RL+ AL +S +++ +L K L+ ++ Q LE + ++R
Sbjct: 902 EKTSGGLSRLQDEIQRLRQAL-----QASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956
Query: 413 QEELSQAESTIDELKEQVDAALGAEE-MVEMLTDRNLNLEEKVRELRETV-------GDL 464
Q++ ++ ++E +++ L E+ VE+LTDR ++V +LR + DL
Sbjct: 957 QDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL 1016
Query: 465 EAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETV--ADYQQTI----- 517
E ++++ E Q +T L E A + + + + + QE + + ++T+
Sbjct: 1017 EC-DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTN 1075
Query: 518 ----KKYRQLTAHLQDVNRELTNQQE 539
+K ++L+ ++D + + +Q++
Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKD 1101
Score = 40.4 bits (93), Expect = 0.011
Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 36/197 (18%)
Query: 896 LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKEL 955
L+ T +L E + + +E + A LR E G +LE++ +++
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR----GRELEEQNLQLQKT 689
Query: 956 KKSLKIKGEELSEANV-----------RLSLLEKKLDSAAKDADE---RIEKVQTRLEET 1001
+ L+ EE S+A + R + +E L ++ DE RI ++ +L+ET
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET 749
Query: 1002 QALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ---------SKRTIEGLRGPP 1052
+ L+ E D LQ +LEAEK +L++ LN+ +KR +E
Sbjct: 750 RGLVDGGEAVEARLRDKLQ----RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 1053 PSGIATLVSGIAGEEQQ 1069
G+A L G+EQQ
Sbjct: 806 QRGLARL-----GQEQQ 817
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 91.7 bits (226), Expect = 4e-18
Identities = 84/374 (22%), Positives = 180/374 (48%), Gaps = 16/374 (4%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 273
E + L +++ + KL+ +++ E +L + ++ K+ Q E++QEW+ K+QEQ+ +
Sbjct: 327 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 384
Query: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333
R +E +E +E + +E M E + E +KE R E + E E ++
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
E + E ++ E EEK + Q K+ +EQ A++ ++R+ +++ K+ +
Sbjct: 445 EKMHEQEKIR-EQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQEEKMWR 502
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE---QVDAALGAEEMVEMLTDRNLNL 450
EK +++ ++ +++ + QEE+ + E I E +E Q + EE + ++
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 451 EEKVRELRETVGDLE----AMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 506
EEK+ + E + + E E E +E RE E ++REQ +M + + ++ E
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622
Query: 507 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ---QQPPPETFDFKIKFAETK 563
E Q+ +K R+ +++ +++ Q+E E++ Q+ + ++ + K E +
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682
Query: 564 AHAKAIEMELRQME 577
+ E ++R+ E
Sbjct: 683 EKMQEQEEKMRRQE 696
Score = 89.0 bits (219), Expect = 3e-17
Identities = 70/367 (19%), Positives = 170/367 (46%), Gaps = 19/367 (5%)
Query: 223 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKE 282
++++ EEK++ K E + K++E E+ + E++ K + +Q ++ +E +
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428
Query: 283 AKEALEAKERYMEEMADTADAIEMATLDKEMAEE----RAESLQQEVEALKERVDELTTD 338
+E + KE + E+ + E +E +E R + +QE EA R +E +
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488
Query: 339 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 398
E E EEK ++ +++ E+ R ++ R +QE + QK EK
Sbjct: 489 QEEKIREQEEKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIREQEEIWRQK--EKI 545
Query: 399 NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELR 458
+++ E +R+Q E++ + + ++++EQ + EE + EEK+RE
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR-------EQEEKIREQE 598
Query: 459 ETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 518
E + + E M + +E E E E++ ++R ++++ ++ + + ++ I+
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 519 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 578
+ ++ +Q+ ++ Q+E E++++ + + K++ E K + + + ++ ++
Sbjct: 659 EQEEM---MQEQEEKMWEQEEKMCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKM 713
Query: 579 AQANRHM 585
+ H+
Sbjct: 714 QEHQEHL 720
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 46/381 (12%)
Query: 202 TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 261
TS G P + A R+LE ++ T+R+ + K +L+ + L Q
Sbjct: 161 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 213
Query: 262 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 307
+++ + DL RL ++ K E ++AL A +RY+EE+ DA+ +
Sbjct: 214 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273
Query: 308 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 351
T+ E +E+ LQ++++ ++ E+ +++ LK AE + G
Sbjct: 274 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 333
Query: 352 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 406
+ + S +L+ E+N L + L + ++ ++E + K+Q+ EK ++ E +R
Sbjct: 334 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 407 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 466
+Q E+++ + ++++ Q + EE + + EEK+REL E + + E
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 467 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 526
+ E ++ QE + E E R++ + A++ ++++ +E + + ++ + + +
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 527 LQDVNRELTNQQEASVERQQQ 547
+ + E Q++ + RQ++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEE 530
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/322 (23%), Positives = 163/322 (50%), Gaps = 29/322 (9%)
Query: 215 KEEEGLRAQVRDLEEKLETLRL--KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 272
++EE +R Q + EK E +R ++ ++ K++E E+ + + E+++E + K QEQ+A +
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKM 479
Query: 273 QRRLKEARKEAKEALEAKERY--MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 330
R+ ++ R++ ++ E +E+ EE + I ++E +E+ E +QE E ++E
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQE-EKIRE 534
Query: 331 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 390
+ +E+ E + E EEK +++ EE+ R ++ +M D +++ K
Sbjct: 535 Q-EEIWRQKEKIH-EQEEK----------IRKQEEKMWRQEE---KMHDQEEKIREQEEK 579
Query: 391 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 450
+ + EK ++ E +R+Q E+++E+ + +++ EQ + EE ++ ++
Sbjct: 580 VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 451 EEKVRE----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 506
EEK+RE +RE + EM E +E E E ++ EQ + + + +++ E
Sbjct: 640 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 699
Query: 507 QETVADYQQTIKKYRQLTAHLQ 528
E +Q +K ++ HL+
Sbjct: 700 WEQEVRLRQQEEKMQEHQEHLE 721
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/299 (22%), Positives = 150/299 (50%), Gaps = 29/299 (9%)
Query: 223 QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 270
++R+LEEK+ E +++ E+K K++E EK + Q E+++E + K++EQ+
Sbjct: 439 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 498
Query: 271 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 327
+ R+ ++ ++ K E K + EEM + I E KE E+ E ++++ E
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 328 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 387
+ + +++ E ++ + E+ Q +++ EQ ++++ ++ ++
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 388 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
K+ + EK ++ E +R+Q E+++E+ + ++++EQ EEM++ ++
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKM 671
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 506
EEK+ E E + + E E +E E E+ LR+Q + +++E Q+ +EAA
Sbjct: 672 WEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHLEAA 723
Score = 75.1 bits (183), Expect = 4e-13
Identities = 75/340 (22%), Positives = 158/340 (46%), Gaps = 22/340 (6%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRA---EDKAKLKELEKHKIQLEQ-VQEWKSKMQEQQA 270
++EE +R Q + EK E +R + E + K++ E+ + E+ ++E + KM EQ+
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE- 451
Query: 271 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 330
+ R +E +++ +E + +E+ E+ A E +E E+ E + ++ E + E
Sbjct: 452 --KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 331 ----RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386
R +E + E + + EEK + Q +++ EQ +++ +M
Sbjct: 510 QEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 446
+ K+++ EK ++ E +R+Q E+++E+ ++++EQ + EE + ++
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQ-------EEKIREQEEMTQEQEEKMGEQEEK 621
Query: 447 NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 506
EEK++E E + E E ++ RE E ++REQ +M + + ++ E
Sbjct: 622 MCEQEEKMQEQEE---KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678
Query: 507 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
E Q+ +K R+ + + L Q+E E Q+
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 68.2 bits (165), Expect = 5e-11
Identities = 48/225 (21%), Positives = 115/225 (51%), Gaps = 7/225 (3%)
Query: 215 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 272
++EE + Q +R+ E++ E + R E+K ++E E+ Q E++ E + K+++Q+ +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK--IREQEEIWRQKEKIHEQEEKIRKQEEKM 559
Query: 273 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 332
R+ ++ + ++ E +E+ + + E +E E+ E Q++ E + E+
Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619
Query: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 392
+++ E ++ + E+ Q K++ EQ ++++ M++ ++ K+
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 393 KLMEKKNQELEVVRQQRERLQEE---LSQAESTIDELKEQVDAAL 434
+ EK ++ E +R+Q E++ E+ L Q E + E +E ++AA+
Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 64.3 bits (155), Expect = 7e-10
Identities = 58/275 (21%), Positives = 132/275 (48%), Gaps = 25/275 (9%)
Query: 216 EEEGLRAQV--RDLEEKLETLRLKRAEDKAKL-KELEKHKIQLEQVQEWKSKM--QEQQA 270
E+E +R Q R EEK+ KR E +AK+ ++ EK + Q E+++E + KM QE++
Sbjct: 449 EQEKIREQEEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507
Query: 271 DLQRRLKEARK---------------EAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
Q +++E K E +E KE+ E+ E +E
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
++ E ++++ E + + +++ E ++ + E+ + Q +++ EQ ++ +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG 435
+M++ +++ K+++ +K ++ E +R+Q E +QE+ + +++ EQ +
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687
Query: 436 AEEMV----EMLTDRNLNLEEKVRELRETVGDLEA 466
EE + E + ++ + L ++ +++E LEA
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 48.1 bits (113), Expect = 5e-05
Identities = 56/311 (18%), Positives = 136/311 (43%), Gaps = 27/311 (8%)
Query: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA----EERAESLQQEVEALKERV 332
++ +K + + EA R +E T + + +MA + + L+ E L R+
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228
Query: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 392
+ L+ + + + +++L ++ L L R K+++ KLQ
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288
Query: 393 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA-ALGAEEMVEMLTDRNLNLE 451
+ ++ E ++ + L+ +L +A+ + + + Q +A LG E L+
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE------------LQ 336
Query: 452 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 511
+L+ V + E N +N + +E E +++E + +++E ++++ +E +
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEEKIR 392
Query: 512 DYQQTIKKYRQLTAHLQDVNR---ELTNQQEASVERQQQPPPETFDFKIKFAETKAH--A 566
+ ++ +++ ++ ++ R E+ ++E + RQ++ E + KI+ E K H
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQE 451
Query: 567 KAIEMELRQME 577
K E E ++ E
Sbjct: 452 KIREQEEKRQE 462
Score = 35.4 bits (80), Expect = 0.35
Identities = 17/106 (16%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 1000
K+ ++E I+E ++ ++ + E E ++ E+K+ + ++ +E++ + + ++ E
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645
Query: 1001 TQALLRKKEKEFEETMDALQADIDQL---EAEKAELKQRLNSQSKR 1043
+ +R++E++ E + +Q +++ E + E ++++ Q ++
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691
Score = 34.7 bits (78), Expect = 0.60
Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%)
Query: 946 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 1005
++R+ + EL ++ I EEL E N +L + ++S + +++++ +LE + LL
Sbjct: 261 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319
Query: 1006 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 1042
+++ + E + + ++ A + Q + E+ EL RLN Q +
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 360
Score = 34.7 bits (78), Expect = 0.60
Identities = 17/83 (20%), Positives = 49/83 (59%), Gaps = 3/83 (3%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 1000
K+ ++E I+E ++ ++ + E + E ++ E+K+ + ++ +E++ + + ++ E
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701
Query: 1001 TQALLRKKEKEFEETMDALQADI 1023
+ LR++E++ +E + L+A I
Sbjct: 702 QEVRLRQQEEKMQEHQEHLEAAI 724
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/99 (23%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 1003
K+ D+E I+E ++ + + E++ E ++ E+K+ + E+ EK+ + EE
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ-EEKMC 623
Query: 1004 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 1042
+K +E EE M + I + E + E ++++ Q +
Sbjct: 624 EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662
Score = 31.2 bits (69), Expect = 6.6
Identities = 18/109 (16%), Positives = 58/109 (53%), Gaps = 6/109 (5%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 1000
K+ ++E I++ ++ + + E++ + ++ E+K+ + ++ +E+I + + ++ E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 1001 TQALLRKKEK---EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1046
+ + +++E+ E EE M + + + E + ++++ Q K+ E
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 91.3 bits (225), Expect = 5e-18
Identities = 73/352 (20%), Positives = 180/352 (51%), Gaps = 28/352 (7%)
Query: 215 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 271
++EE LR Q +R+ EEK+ + E + +L+E EK + ++++E + +MQEQ+
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Query: 272 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 331
+ + ++ R++ ++ +ER E+ + + +E E+ E L+++ E ++E+
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 332 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 391
+++ +E ++ E + + + + K EE+ R ++ +R + + E++E ++
Sbjct: 417 -EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 392 QK----LMEKKNQELEVVRQQRERL--QEELSQAESTIDELKEQV---------DAALGA 436
Q+ E+K + + + +Q+E+L QE++ + E I E +E++ + +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDL-EAMNEMNDELQENARETELELREQLDMAGAR 495
+E + D+ EEK+R+ + + D E M + E ++ + E ++RE+ R
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-----ER 590
Query: 496 VREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 547
+RE +K++ +E + + ++ K ++ +Q+ ++ Q+E E++++
Sbjct: 591 MREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Score = 88.2 bits (217), Expect = 5e-17
Identities = 88/392 (22%), Positives = 184/392 (46%), Gaps = 47/392 (11%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKLETLRL--------------------KRAEDKAKLKELE 249
LP E+ ++ V++L+ KLE + R ++K K+ E
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 250 KHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATL 309
K Q E+++E + KM+EQ+ + R+ K R++ KE L +E+ + E + + E
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELREQKELREQEEQMQE 352
Query: 310 DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR 369
+E E+ E ++++ E + R +E + E E E+K D Q +++ EQ+ R
Sbjct: 353 QEEKMWEQEEKMREQEEKM-WRQEERLWEQEKQMREQEQKMRD------QEERMWEQDER 405
Query: 370 LKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 425
L++ RMR+ EK K + EKK ++ E Q+ ER++E + +
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
Query: 426 LKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 485
++EQ + EE + ++ ++++ E +E + + E M E +++ E E ++
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEKMQEQEEKIWEQ----EEKI 520
Query: 486 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 545
R+Q +M G Q++ QE + + + + + + ++D +++ +Q+E ++
Sbjct: 521 RDQEEMWG------QEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKMWDQEERMEKKT 571
Query: 546 QQPPPETFDFKIKFAETKAHAKAIEMELRQME 577
Q+ +T+D + K E + + E ++R+ E
Sbjct: 572 QEQEKKTWDQEEKMRE-EERMREREKKMREEE 602
Score = 85.1 bits (209), Expect = 4e-16
Identities = 86/402 (21%), Positives = 184/402 (45%), Gaps = 35/402 (8%)
Query: 215 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 272
++E+ LR Q +R+ EE+++ K E + K++E E+ K+ ++ + W+ + Q ++ +
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQ 390
Query: 273 QRRLKEARK-EAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA-----ESLQQEVE 326
+ R +E R E E L KE M E + +E +K+M E+ E QE E
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386
++ER ++ + E ++ E EEK + ++ ++ E Q RL + ++ + ++Q
Sbjct: 451 RIREREKKMREEEETMR-EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 387 EHV------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
E K++ E QE ++ RQ++ R QE+ Q +++++Q EE +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED--QMWEQEEKMRDQEQKMWDQEERM 567
Query: 441 EMLT-----------------DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 483
E T +R E+K+RE E + + E + +E + E
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627
Query: 484 ELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 543
E E++ ++ E ++++ +E + + Q+ ++ +L H + +E +QE +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 544 RQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 585
Q++ +T + + K + + + M R+ ++ + M
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Score = 81.6 bits (200), Expect = 4e-15
Identities = 75/388 (19%), Positives = 179/388 (46%), Gaps = 25/388 (6%)
Query: 215 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 271
+EE+ ++ Q RD EEK++ R +K +E E + Q E++Q+ + M EQ+
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 272 --LQRRLKEARK---EAKEALEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEV 325
Q+RL E ++ E ++ E +E+ E+ D EM +K+M +E+ + ++
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 326 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEK 385
+E++ + + + +E+K + ++ ++ + R+++ +MR+ +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 386 QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE---- 441
++ K+Q+ EK ++ E + +Q E++QE+ + +++ EQ + + + E
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 442 MLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ------------ENARETELELREQL 489
+ + +EK++E E + + E M + E + E+ RE E ++RE+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 490 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 549
+M + + Q++ E QE + + +K + + + R +++ + Q
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 550 PETFDFKIKFAETKAHAKAIEMELRQME 577
+ ++ + K + + + E ++R E
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/320 (21%), Positives = 155/320 (48%), Gaps = 20/320 (6%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAE--DKAKLKELEKHKIQLEQVQEWKSKMQEQQA--- 270
E+E ++ Q + E+ E +R + + K+ EK + Q +Q+ E + KM++Q+
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 271 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 330
D + R+++ +E ++ +E M E + + ++EM E+ E +Q++ E ++E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 331 RVDELTTDLEILKA------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 384
+ +++ E ++ E EEK + ++ ++L EQ +L + E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 385 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE------STIDELKEQVDAALGAEE 438
++E + Q+ MEKK QE E +E+++EE S E + ++EQ + EE
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 439 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 498
++ + EEK+ E E + + + + E ++L E+ + E +E++ ++R+
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE---QEKIWEQEEKMRD 798
Query: 499 AQKRVEAAQETVADYQQTIK 518
++++ +E + ++ ++
Sbjct: 799 QEEKMRGQEEKMRGQEEKMR 818
Score = 75.9 bits (185), Expect = 2e-13
Identities = 76/337 (22%), Positives = 154/337 (45%), Gaps = 36/337 (10%)
Query: 226 DLEEKLETLRLKRAEDKAKLKELEKHK----IQLEQVQEWKSKMQEQQADLQRRLKEARK 281
+L+ L + + + ++EL K + ++L + +++++ A+LQ +L A
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 282 EAKEA-LEAKE--RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE-----RVD 333
E E L KE R +E ++ TL +EM + E +QE + K+ R +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 334 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 393
E + E E EEK Q K+L EQ L++ +R+ +QE ++Q+
Sbjct: 300 ERLREQEGKMREQEEK------MWRQEKRLREQEKELREQEKELREQKELREQEE-QMQE 352
Query: 394 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 453
EK ++ E +R+Q E++ + + +++EQ EE + +R EE+
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 454 VRELRETVGDLEAMNEMN--DELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 511
+RE + +E M E E ++ R+ E +++E+ R+RE +K++ +ET+
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-----ERIREREKKMREEEETMR 467
Query: 512 DYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQP 548
+ ++ ++K + + Q+E ++Q+ P
Sbjct: 468 EQEEKMQKQEE----------NMWEQEEKEWQQQRLP 494
Score = 64.7 bits (156), Expect = 5e-10
Identities = 64/281 (22%), Positives = 139/281 (49%), Gaps = 28/281 (9%)
Query: 215 KEEEGLRAQVRDLEEKLETL--RLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 272
++EE ++ Q + E+ E + + ++ ++ +L E ++ + E++QE + KMQEQ+ +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE-QEKMQEQEEKI 686
Query: 273 --QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 330
Q ++++ +E ++ +E+ EE + +M ++EM E+ E +Q++ E ++E
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE-EEEMMREQEEKMQEQEEKMQE 745
Query: 331 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 390
+ +E+ E EEK + ++ ++L EQ +L + + QE K
Sbjct: 746 QEEEMW--------EQEEKMWEQEEKMWEQQRLPEQKEKLWE---------HEKMQEQEK 788
Query: 391 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 450
+ + EK + E +R Q E+++ + + +++ Q + G EE + ++
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 451 EEKVRELRETVGDLEAMNEMNDEL---QENARETELELREQ 488
EEK+ E + G E M E +++ +E RE E ++R Q
Sbjct: 849 EEKMEEKMQ--GQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 33.1 bits (74), Expect = 1.7
Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 5/102 (4%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 1003
K+ ++E ++E ++ + + E L E ++ E+K+ +D +ER+ + RL E +
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM----RDQEERMWEQDERLREKEE 411
Query: 1004 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTI 1045
+R++EK +E+ ++ ++ + E EK Q Q + I
Sbjct: 412 RMREQEKMWEQ-VEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Score = 32.0 bits (71), Expect = 3.9
Identities = 22/103 (21%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV---QTRLEE 1000
K+ + E++ +E +K ++ + E + E ++ E+K+ ++ E+ EK+ + ++ E
Sbjct: 708 KMREEESM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 1001 TQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1043
Q L +KEK +E Q I + E + + ++++ Q ++
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809
Score = 31.6 bits (70), Expect = 5.1
Identities = 23/114 (20%), Positives = 56/114 (49%), Gaps = 13/114 (11%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV--------- 994
++ +RE ++E ++ ++ + E++ E ++ E+K+ + E+ EK+
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 995 -QTRLEETQALLRKKEKEFEETMDALQADIDQLEA---EKAELKQRLNSQSKRT 1044
+ ++ E Q L +KEK +E Q + + E E+ +++++ Q K+T
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
Score = 30.8 bits (68), Expect = 8.7
Identities = 23/112 (20%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 1003
K+ D+E + E + L+ K E + E +EK + E+ + Q + +
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 1004 LLRKKEKEFEETMDALQADIDQL---------EAEKAELKQRLNSQSKRTIE 1046
+R++EK+ E + ++ +++ + EK +QRL Q ++ E
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 91.3 bits (225), Expect = 5e-18
Identities = 199/973 (20%), Positives = 384/973 (39%), Gaps = 169/973 (17%)
Query: 210 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 258
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
Query: 259 QEWKSKMQEQQADLQRRLKEARK------EAKEALE-----AKERYMEEMADTADA---- 303
+ K K+++Q DL+ L++ +K AK LE A+E M+ D
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 304 ----IEMATLDKEMAEERA--ESLQQEVEALKERVDELTTDLEI---LKAEIEEKGSD-- 352
EM+ L ++ +E+A LQ++++ L+ R++EL ++E +A+ E++ SD
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 353 -------------GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK- 398
G A+S Q++ +++ A + RDL + Q L +K
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKHA 1201
Query: 399 ------NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNL 448
++++ +++ +++L++E S+ + ID+L ++ A E+M L D+
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261
Query: 449 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 508
++ K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRA---RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 509 TVADYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIK 558
++ IK L LQ + + +QEA E Q+ + E ++ K
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 559 FAETKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLL 611
+ ET A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1379 Y-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 612 MPRLICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLL 663
C A +++ +K E + C E L + E S + L Y SL
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497
Query: 664 QA-TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLD 712
Q TL R L Q D+ +++ + ++ + L +E
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 713 ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------R 766
E + + + + +AE+ E+ +HI+ +S + E+ R
Sbjct: 1558 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617
Query: 767 LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDT 826
L+ ++G L ++E + + + R T A L + D
Sbjct: 1618 LKKKMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL----HLDDA 1664
Query: 827 LL---DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 883
L D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV------ 1717
Query: 884 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 943
+ L LI+T KL T + + + + E + E +A + ITDA +
Sbjct: 1718 ---QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAAMMAE 1771
Query: 944 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIE 992
+L+ + L++ K + + + RL E+ KL++ ++ + +E
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831
Query: 993 KVQTRLEETQALLRKKEKEFEE-----------------TMDALQADID--QLEAEKAEL 1033
Q R E LRK E++ +E +D LQA + + +AE+AE
Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 1034 KQRLNSQSKRTIE 1046
+ +N R I+
Sbjct: 1892 QSNVNLSKFRRIQ 1904
Score = 89.4 bits (220), Expect = 2e-17
Identities = 174/877 (19%), Positives = 353/877 (40%), Gaps = 107/877 (12%)
Query: 208 PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ----VQEWKS 263
P L S E+E + +++E+ E + + A+ +AK KELE+ + L Q +Q
Sbjct: 842 PLLKSAETEKE-----MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896
Query: 264 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 323
+ AD + R + K K LEAK + + E A+ + I K+ L+
Sbjct: 897 AEADSLADAEERCDQLIK-TKIQLEAKIKEVTERAEDEEEINAELTAKK------RKLED 949
Query: 324 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 383
E LK+ +D DLE+ A++E+ + A+ ++K L E+ A L + + ++ +
Sbjct: 950 ECSELKKDID----DLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TK 998
Query: 384 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 443
EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ + M
Sbjct: 999 EK------KALQEAHQQTLDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKIRMD 1051
Query: 444 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 502
+R LE ++ +E+ D+E + DE + L+ +++ A + QK+
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKK 1111
Query: 503 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 562
++ Q + + ++ I+ R A + +L+ + E ER ++ T +
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMN 1168
Query: 563 KAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 620
K + R +E A Q + L DS G D + + K +
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQK 1220
Query: 621 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 680
L +++++ K E+ + S + A G L LS ++ + ++ D
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN----D 1276
Query: 681 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 740
+ + L E + R LD KD L V L++ + + +Q E
Sbjct: 1277 LTAQRARLQTESGEYSRQLD------EKDTL-----VSQLSRGKQAF--------TQQIE 1317
Query: 741 DCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF 797
+ QL + IK + AL + LR + QEA A L R + + S++ Q+
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK--AELQRAMSKANSEVAQW 1375
Query: 798 CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
K TDA Q ++ L + +K L + +E A A L +
Sbjct: 1376 RTKYE-----TDA----------IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERP 917
+ L +E+L E +C L + E + E
Sbjct: 1421 TKQRLQNEVEDLMIDV-------------ERTNAACAALDKKQRNFDKILAEWKQKCEET 1467
Query: 918 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE 977
++ + + +L E+ + + D+ +K K+L+ + +L+E
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527
Query: 978 KKLDSAAKDADERIEKVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELK 1034
+L+ K ++ ++Q LEE +A L +E + + ++ +++++D+ AEK E
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1587
Query: 1035 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 1071
++ R +E ++ + I + I +++ G
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624
Score = 55.1 bits (131), Expect = 4e-07
Identities = 52/278 (18%), Positives = 129/278 (46%), Gaps = 13/278 (4%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1662 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1717
Query: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV---D 333
+ + + K++ +++ +E + AEE+A+ + + E +
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 334 ELTTDLEILKAEIEEKGSD-----GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEH 388
+ + LE +K +E+ D A LK ++Q +L+ + + SE++ +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837
Query: 389 VKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNL 448
V+ K + K ++++ + Q E ++ + + + +D+L+ +V + E E ++ NL
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897
Query: 449 NLEEKVR-ELRETVGDLEAMNEMNDELQENARETELEL 485
+ +++ EL E + ++L+ +RE ++
Sbjct: 1898 SKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/257 (21%), Positives = 115/257 (44%), Gaps = 40/257 (15%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 261
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 262 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 317 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEE-QNAR 369
++L+Q V+ L+ R+DE +I K E + +G S Q + +E + R
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 370 LKDALVRMRDLSSSEKQEHV-KLQKLMEKKNQELEVVRQQRE--------------RLQE 414
+ V+ + E ++++ +LQ L++K +++ ++Q E R+Q
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 415 ELSQAESTIDELKEQVD 431
EL +AE D + QV+
Sbjct: 1906 ELEEAEERADIAESQVN 1922
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 330
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 331 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 376
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 555
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048
Query: 556 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 615
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089
Query: 616 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 674
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 675 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 733
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 734 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 793
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+++ +K++ QV++ A VAA A +
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294
Query: 854 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 911
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348
Query: 912 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 970
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1027
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1028 AEKAELKQ-----RLNSQSKRTIE 1046
EK +L+Q +L S+ +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 215 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663
Query: 274 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 305
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 306 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 354
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 355 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 394
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 395 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 435
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 436 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 481
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962
Query: 482 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 531
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021
Query: 532 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 591
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079
Query: 592 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 650
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 651 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 710
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183
Query: 711 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 769
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 828
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299
Query: 829 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 888
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 942
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 943 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 992
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 993 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 270
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 271 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 328
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 329 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 380
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253
Query: 441 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 497
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 498 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 543
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 544 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 593
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 650
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 651 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519
Query: 456 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 515
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575
Query: 516 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
++ RQ L + N+ L Q + E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 84.0 bits (206), Expect = 9e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 275
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623
Query: 395 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 445 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 499
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 559
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799
Query: 560 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 618
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842
Query: 619 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 678
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888
Query: 679 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 739 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
+ +E+GR+R+ A D E + RQ
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976
Query: 799 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030
Query: 859 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 975 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1034
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 1035 QRLNSQSKRTIEGLR 1049
+ L E R
Sbjct: 2207 EELQRLKAEATEAAR 2221
Score = 82.4 bits (202), Expect = 3e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 221 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 339
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 340 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 391
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525
Query: 392 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680
Query: 570 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719
Query: 626 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 685
A E + +R L AA L+A L + ++ V + K
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772
Query: 686 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 800
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 801 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 915
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 916 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 970
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1030
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095
Query: 1031 AELK-QRLNSQSKRTIE 1046
A ++ +R +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112
Score = 70.9 bits (172), Expect = 8e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 210 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 255
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 256 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 428
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 429 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 475
+ G+E +++ D + E + + + +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 476 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 535
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402
Query: 536 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 593
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 643
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 644 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576
Query: 702 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 758
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 759 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 796
++ LR LQ + A +L + E + Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 850
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 901
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 956
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870
Query: 957 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 1015
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926
Query: 1016 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 1070
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 391
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562
Query: 392 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 507
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676
Query: 508 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 549
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 267 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 321
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027
Query: 322 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 369
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 370 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 480
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 481 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 536
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 537 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 596
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318
Query: 597 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 656
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 716
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430
Query: 717 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 776
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472
Query: 777 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 831
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 832 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 886
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647
Query: 947 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 996
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 997 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1054
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762
Query: 1055 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 1110
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1111 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1168
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874
Query: 1169 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1214
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1781
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 330
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 331 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 376
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1902 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1945
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2002
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 555
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 2003 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2052
Query: 556 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 615
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2053 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2093
Query: 616 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 674
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153
Query: 675 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 733
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 734 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 793
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2212 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2269
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+++ +K++ QV++ A VAA A +
Sbjct: 2270 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2298
Query: 854 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 911
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2352
Query: 912 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 970
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2353 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1027
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 1028 AEKAELKQ-----RLNSQSKRTIE 1046
EK +L+Q +L S+ +T++
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ 2484
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 215 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1667
Query: 274 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 305
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 306 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 354
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 355 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 394
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 395 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 435
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 436 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 481
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1966
Query: 482 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 531
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2025
Query: 532 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 591
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2083
Query: 592 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 650
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2084 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 651 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 710
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2187
Query: 711 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 769
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2245
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 828
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2303
Query: 829 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 888
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2360
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 942
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2361 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 943 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 992
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 993 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2479 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2522
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 270
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079
Query: 271 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 328
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 329 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 380
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2257
Query: 441 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 497
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 498 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 543
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 544 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 593
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 650
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 651 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2498 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2302 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2417
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2473
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2474 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2523
Query: 456 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 515
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2524 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2579
Query: 516 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
++ RQ L + N+ L Q + E+ +
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Score = 84.0 bits (206), Expect = 9e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 275
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1571
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1627
Query: 395 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 445 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 499
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 559
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1803
Query: 560 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 618
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1846
Query: 619 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 678
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1892
Query: 679 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1947
Query: 739 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
+ +E+GR+R+ A D E + RQ
Sbjct: 1948 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1980
Query: 799 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1981 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2034
Query: 859 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154
Query: 975 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1034
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 1035 QRLNSQSKRTIEGLR 1049
+ L E R
Sbjct: 2211 EELQRLKAEATEAAR 2225
Score = 82.4 bits (202), Expect = 3e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 221 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 339
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 340 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 391
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1480 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1529
Query: 392 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1581
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1582 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1684
Query: 570 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1723
Query: 626 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 685
A E + +R L AA L+A L + ++ V + K
Sbjct: 1724 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1776
Query: 686 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 800
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1837 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 801 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1937
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 915
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1938 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991
Query: 916 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 970
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2048
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1030
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2049 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2099
Query: 1031 AELK-QRLNSQSKRTIE 1046
A ++ +R +QS+R +E
Sbjct: 2100 ARVQAEREAAQSRRQVE 2116
Score = 70.9 bits (172), Expect = 8e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 210 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 255
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1057 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1116
Query: 256 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1117 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1232
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 428
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292
Query: 429 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 475
+ G+E +++ D + E + + + +E +
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352
Query: 476 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 535
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1406
Query: 536 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 593
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 643
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1467 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 644 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1580
Query: 702 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 758
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 759 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 796
++ LR LQ + A +L + E + Q
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 850
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 901
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1757 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 956
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1874
Query: 957 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 1015
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1930
Query: 1016 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 1070
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2461
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2462 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 391
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2566
Query: 392 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2623
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 507
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2680
Query: 508 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 549
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2727
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 267 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 321
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 977 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1031
Query: 322 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 369
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091
Query: 370 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 480
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1152 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 481 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 536
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 537 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 596
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1269 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1322
Query: 597 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 656
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1323 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 716
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1434
Query: 717 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 776
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1435 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1476
Query: 777 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 831
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 832 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 886
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1651
Query: 947 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 996
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 997 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1054
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1766
Query: 1055 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 1110
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 1111 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1168
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1827 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1878
Query: 1169 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1214
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 330
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 331 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 376
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 555
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048
Query: 556 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 615
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089
Query: 616 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 674
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 675 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 733
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 734 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 793
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+++ +K++ QV++ A VAA A +
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294
Query: 854 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 911
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348
Query: 912 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 970
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1027
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1028 AEKAELKQ-----RLNSQSKRTIE 1046
EK +L+Q +L S+ +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 215 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663
Query: 274 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 305
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 306 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 354
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 355 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 394
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 395 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 435
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 436 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 481
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962
Query: 482 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 531
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021
Query: 532 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 591
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079
Query: 592 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 650
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 651 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 710
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183
Query: 711 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 769
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 828
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299
Query: 829 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 888
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 942
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 943 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 992
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 993 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 270
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 271 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 328
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 329 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 380
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253
Query: 441 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 497
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 498 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 543
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 544 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 593
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 650
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 651 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519
Query: 456 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 515
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575
Query: 516 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
++ RQ L + N+ L Q + E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 84.0 bits (206), Expect = 9e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 275
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623
Query: 395 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 445 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 499
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 559
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799
Query: 560 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 618
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842
Query: 619 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 678
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888
Query: 679 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 739 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
+ +E+GR+R+ A D E + RQ
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976
Query: 799 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030
Query: 859 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 975 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1034
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 1035 QRLNSQSKRTIEGLR 1049
+ L E R
Sbjct: 2207 EELQRLKAEATEAAR 2221
Score = 82.4 bits (202), Expect = 3e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 221 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 339
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 340 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 391
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525
Query: 392 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680
Query: 570 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719
Query: 626 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 685
A E + +R L AA L+A L + ++ V + K
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772
Query: 686 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 800
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 801 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 915
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 916 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 970
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1030
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095
Query: 1031 AELK-QRLNSQSKRTIE 1046
A ++ +R +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112
Score = 70.9 bits (172), Expect = 8e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 210 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 255
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 256 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 428
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 429 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 475
+ G+E +++ D + E + + + +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 476 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 535
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402
Query: 536 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 593
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 643
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 644 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576
Query: 702 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 758
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 759 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 796
++ LR LQ + A +L + E + Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 850
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 901
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 956
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870
Query: 957 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 1015
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926
Query: 1016 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 1070
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 391
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562
Query: 392 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 507
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676
Query: 508 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 549
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 267 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 321
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027
Query: 322 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 369
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 370 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 480
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 481 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 536
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 537 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 596
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318
Query: 597 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 656
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 716
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430
Query: 717 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 776
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472
Query: 777 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 831
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 832 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 886
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647
Query: 947 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 996
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 997 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1054
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762
Query: 1055 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 1110
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 1111 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1168
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874
Query: 1169 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1214
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1745
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 330
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 331 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 376
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1866 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1909
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1966
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 555
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1967 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2016
Query: 556 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 615
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2017 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2057
Query: 616 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 674
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117
Query: 675 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 733
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 734 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 793
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2176 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2233
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+++ +K++ QV++ A VAA A +
Sbjct: 2234 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2262
Query: 854 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 911
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2316
Query: 912 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 970
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2317 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1027
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 1028 AEKAELKQ-----RLNSQSKRTIE 1046
EK +L+Q +L S+ +T++
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ 2448
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 215 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1631
Query: 274 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 305
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 306 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 354
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 355 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 394
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 395 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 435
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 436 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 481
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1930
Query: 482 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 531
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1989
Query: 532 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 591
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2047
Query: 592 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 650
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2048 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 651 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 710
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2151
Query: 711 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 769
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2209
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 828
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2267
Query: 829 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 888
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2324
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 942
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2325 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 943 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 992
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 993 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2443 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2486
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 270
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043
Query: 271 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 328
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 329 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 380
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2221
Query: 441 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 497
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 498 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 543
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 544 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 593
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 650
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 651 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2462 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2266 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2381
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2437
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2438 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2487
Query: 456 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 515
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2488 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2543
Query: 516 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
++ RQ L + N+ L Q + E+ +
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Score = 84.0 bits (206), Expect = 9e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 275
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1535
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1591
Query: 395 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 445 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 499
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 559
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1767
Query: 560 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 618
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1810
Query: 619 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 678
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1856
Query: 679 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1911
Query: 739 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
+ +E+GR+R+ A D E + RQ
Sbjct: 1912 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1944
Query: 799 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1945 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 1998
Query: 859 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118
Query: 975 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1034
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 1035 QRLNSQSKRTIEGLR 1049
+ L E R
Sbjct: 2175 EELQRLKAEATEAAR 2189
Score = 82.4 bits (202), Expect = 3e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 221 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 339
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 340 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 391
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1444 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1493
Query: 392 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1545
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1546 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1648
Query: 570 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1687
Query: 626 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 685
A E + +R L AA L+A L + ++ V + K
Sbjct: 1688 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1740
Query: 686 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 800
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1801 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 801 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1901
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 915
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1902 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955
Query: 916 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 970
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2012
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1030
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2013 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2063
Query: 1031 AELK-QRLNSQSKRTIE 1046
A ++ +R +QS+R +E
Sbjct: 2064 ARVQAEREAAQSRRQVE 2080
Score = 70.9 bits (172), Expect = 8e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 210 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 255
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1021 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1080
Query: 256 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1081 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1196
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 428
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256
Query: 429 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 475
+ G+E +++ D + E + + + +E +
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316
Query: 476 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 535
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1370
Query: 536 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 593
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 643
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1431 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487
Query: 644 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1544
Query: 702 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 758
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 759 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 796
++ LR LQ + A +L + E + Q
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 850
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 901
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1721 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 956
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1838
Query: 957 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 1015
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1894
Query: 1016 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 1070
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2425
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2426 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 391
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2530
Query: 392 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2587
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 507
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2644
Query: 508 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 549
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2691
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 267 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 321
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 941 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 995
Query: 322 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 369
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 996 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055
Query: 370 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 480
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1116 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 481 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 536
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 537 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 596
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1233 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1286
Query: 597 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 656
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1287 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 716
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1398
Query: 717 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 776
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1399 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1440
Query: 777 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 831
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 832 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 886
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1615
Query: 947 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 996
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 997 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1054
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1730
Query: 1055 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 1110
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 1111 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1168
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1791 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1842
Query: 1169 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1214
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 216 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1914
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 330
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974
Query: 331 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 376
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034
Query: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 2035 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 2078
Query: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2135
Query: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 555
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 2136 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2185
Query: 556 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 615
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2186 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2226
Query: 616 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 674
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286
Query: 675 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 733
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 734 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 793
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2345 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2402
Query: 794 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 853
+++ +K++ QV++ A VAA A +
Sbjct: 2403 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2431
Query: 854 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 911
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2485
Query: 912 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 970
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2486 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1027
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 1028 AEKAELKQ-----RLNSQSKRTIE 1046
EK +L+Q +L S+ +T++
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ 2617
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 215 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1800
Query: 274 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 305
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 306 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 354
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 355 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 394
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 395 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 435
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 436 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 481
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 2099
Query: 482 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 531
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2158
Query: 532 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 591
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2216
Query: 592 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 650
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2217 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 651 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 710
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2320
Query: 711 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 769
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2378
Query: 770 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 828
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2436
Query: 829 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 888
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2493
Query: 889 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 942
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2494 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 943 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 992
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 993 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1035
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2612 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2655
Score = 85.1 bits (209), Expect = 4e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 270
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212
Query: 271 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 328
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 329 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 380
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 381 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 440
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2390
Query: 441 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 497
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 498 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 543
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 544 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 593
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 650
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 651 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 700
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2631 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 275
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2435 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2550
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 395
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2606
Query: 396 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 455
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2607 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2656
Query: 456 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 515
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2657 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2712
Query: 516 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 546
++ RQ L + N+ L Q + E+ +
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Score = 84.0 bits (206), Expect = 9e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 220 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 275
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 276 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 335
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1704
Query: 336 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 394
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1760
Query: 395 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 444
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 445 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 499
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 559
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1936
Query: 560 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 618
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1979
Query: 619 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 678
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 2025
Query: 679 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 738
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 2080
Query: 739 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 798
+ +E+GR+R+ A D E + RQ
Sbjct: 2081 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2113
Query: 799 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 2114 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2167
Query: 859 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 914
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 915 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 974
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287
Query: 975 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1034
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 1035 QRLNSQSKRTIEGLR 1049
+ L E R
Sbjct: 2344 EELQRLKAEATEAAR 2358
Score = 82.4 bits (202), Expect = 3e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 221 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 279
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 280 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 339
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 340 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 391
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1613 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1662
Query: 392 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 449
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1714
Query: 450 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 509
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1715 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 510 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 569
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1817
Query: 570 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 625
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1856
Query: 626 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 685
A E + +R L AA L+A L + ++ V + K
Sbjct: 1857 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1909
Query: 686 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 743
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Query: 744 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 800
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1970 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 801 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 857
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 2070
Query: 858 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 915
E E E G S+ + LR + + + +LA + +AE
Sbjct: 2071 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124
Query: 916 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 970
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2181
Query: 971 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1030
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2182 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2232
Query: 1031 AELK-QRLNSQSKRTIE 1046
A ++ +R +QS+R +E
Sbjct: 2233 ARVQAEREAAQSRRQVE 2249
Score = 70.9 bits (172), Expect = 8e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 210 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 255
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1190 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249
Query: 256 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 315
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1250 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308
Query: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 375
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1365
Query: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 428
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425
Query: 429 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 475
+ G+E +++ D + E + + + +E +
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485
Query: 476 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 535
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1539
Query: 536 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 593
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 594 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 643
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1600 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656
Query: 644 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 701
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1713
Query: 702 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 758
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 759 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 796
++ LR LQ + A +L + E + Q
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 850
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 851 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 901
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1890 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 902 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 956
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 2007
Query: 957 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 1015
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 2063
Query: 1016 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 1070
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 215 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 274
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2594
Query: 275 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 334
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2595 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 391
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2699
Query: 392 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 447
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2756
Query: 448 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 507
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2813
Query: 508 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 549
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2860
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 267 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 321
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 1110 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1164
Query: 322 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 369
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224
Query: 370 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 425 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 480
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1285 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 481 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 536
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 537 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 596
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1402 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1455
Query: 597 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 656
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1456 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 657 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 716
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1567
Query: 717 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 776
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1568 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1609
Query: 777 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 831
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 832 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 886
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 887 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1784
Query: 947 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 996
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 997 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1054
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1899
Query: 1055 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 1110
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 1111 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1168
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1960 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 2011
Query: 1169 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1214
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,681,287
Number of Sequences: 37866
Number of extensions: 2361866
Number of successful extensions: 39204
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 688
Number of HSP's successfully gapped in prelim test: 1834
Number of HSP's that attempted gapping in prelim test: 14868
Number of HSP's gapped (non-prelim): 13862
length of query: 1278
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1164
effective length of database: 13,930,794
effective search space: 16215444216
effective search space used: 16215444216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.