Guide to the Human Genome
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Search of human proteins with 13259508

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
         (1144 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                      2196   0.0  
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                      2189   0.0  
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                     2180   0.0  
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                     2148   0.0  
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      106   1e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    99   2e-20
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                99   2e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         97   7e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    96   1e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    96   1e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    96   1e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    96   1e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     95   4e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    95   4e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    95   4e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    94   6e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    94   7e-19
gi|16262452 cingulin [Homo sapiens]                                    94   1e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    92   4e-18
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    91   5e-18
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    91   5e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        91   5e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        91   5e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         91   5e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         91   5e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         91   5e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         91   5e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         91   5e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         91   5e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    91   6e-18

>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 2196 bits (5690), Expect = 0.0
 Identities = 1144/1144 (100%), Positives = 1144/1144 (100%)

Query: 1    MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
            MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP
Sbjct: 1    MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60

Query: 61   IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
            IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ
Sbjct: 61   IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120

Query: 121  LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
            LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA
Sbjct: 121  LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180

Query: 181  EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
            EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL
Sbjct: 181  EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240

Query: 241  VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
            VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL
Sbjct: 241  VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300

Query: 301  GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
            GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA
Sbjct: 301  GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360

Query: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
            RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD
Sbjct: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420

Query: 421  FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
            FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR
Sbjct: 421  FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480

Query: 481  LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
            LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL
Sbjct: 481  LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
            SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH
Sbjct: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600

Query: 601  LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
            LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI
Sbjct: 601  LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660

Query: 661  RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
            RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP
Sbjct: 661  RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720

Query: 721  LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA
Sbjct: 721  LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS
Sbjct: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
            LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK
Sbjct: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900

Query: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
            QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL
Sbjct: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960

Query: 961  QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
            QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ
Sbjct: 961  QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020

Query: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
            LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR
Sbjct: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080

Query: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140
            PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS
Sbjct: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140

Query: 1141 RLIS 1144
            RLIS
Sbjct: 1141 RLIS 1144


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 2189 bits (5673), Expect = 0.0
 Identities = 1140/1142 (99%), Positives = 1142/1142 (100%)

Query: 3    RQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 62
            ++APTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII
Sbjct: 137  KKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 196

Query: 63   PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 122
            PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE
Sbjct: 197  PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 256

Query: 123  QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
            QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE
Sbjct: 257  QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316

Query: 183  RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
            RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR
Sbjct: 317  RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 376

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA
Sbjct: 377  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
            EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV
Sbjct: 437  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
            REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK
Sbjct: 497  REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 556

Query: 423  IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
            IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI
Sbjct: 557  IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 616

Query: 483  CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 542
            CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ
Sbjct: 617  CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 676

Query: 543  CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 602
            CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA
Sbjct: 677  CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 736

Query: 603  EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 662
            EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ
Sbjct: 737  EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 796

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 722
            FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA
Sbjct: 797  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 856

Query: 723  ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 782
            ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER
Sbjct: 857  ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 916

Query: 783  PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
            PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL
Sbjct: 917  PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 976

Query: 843  EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
            EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR
Sbjct: 977  EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036

Query: 903  LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 962
            LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ
Sbjct: 1037 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 1096

Query: 963  ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1022
            ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL
Sbjct: 1097 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1156

Query: 1023 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1082
            ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG
Sbjct: 1157 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1216

Query: 1083 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1142
            ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL
Sbjct: 1217 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1276

Query: 1143 IS 1144
            IS
Sbjct: 1277 IS 1278


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 2180 bits (5649), Expect = 0.0
 Identities = 1139/1144 (99%), Positives = 1139/1144 (99%), Gaps = 5/1144 (0%)

Query: 1    MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
            MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP
Sbjct: 1    MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60

Query: 61   IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
            IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ
Sbjct: 61   IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120

Query: 121  LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
            LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA
Sbjct: 121  LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180

Query: 181  EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
            EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL
Sbjct: 181  EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240

Query: 241  VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
            VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL
Sbjct: 241  VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300

Query: 301  GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
            GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA
Sbjct: 301  GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360

Query: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
            RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD
Sbjct: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420

Query: 421  FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
            FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR
Sbjct: 421  FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480

Query: 481  LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
            LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL
Sbjct: 481  LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
            SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH
Sbjct: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600

Query: 601  LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
            LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI
Sbjct: 601  LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660

Query: 661  RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
            RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP
Sbjct: 661  RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720

Query: 721  LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA
Sbjct: 721  LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS
Sbjct: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
            LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK
Sbjct: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900

Query: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
            QRLNSQSKRTIEGLRGPPPSGIATLVSGIAG     GAIPGQAPGSVPGPGLVKDSPLLL
Sbjct: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLL 955

Query: 961  QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
            QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ
Sbjct: 956  QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1015

Query: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
            LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR
Sbjct: 1016 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1075

Query: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140
            PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS
Sbjct: 1076 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1135

Query: 1141 RLIS 1144
            RLIS
Sbjct: 1136 RLIS 1139


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 2148 bits (5565), Expect = 0.0
 Identities = 1125/1135 (99%), Positives = 1126/1135 (99%), Gaps = 6/1135 (0%)

Query: 11   TTTRRPK-PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 69
            TT +  K PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS
Sbjct: 124  TTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 183

Query: 70   PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 129
            PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS
Sbjct: 184  PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 243

Query: 130  KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
            KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ
Sbjct: 244  KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303

Query: 190  EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
            EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS
Sbjct: 304  EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363

Query: 250  EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
            EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML
Sbjct: 364  EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423

Query: 310  TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 369
            TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV
Sbjct: 424  TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 483

Query: 370  EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 429
            EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK
Sbjct: 484  EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 543

Query: 430  AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 489
            AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR
Sbjct: 544  AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 603

Query: 490  KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549
            KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK
Sbjct: 604  KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 663

Query: 550  KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
            KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT
Sbjct: 664  KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 669
            MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR
Sbjct: 724  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 783

Query: 670  RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 729
            RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV
Sbjct: 784  RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 843

Query: 730  AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 789
            AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP
Sbjct: 844  AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 903

Query: 790  VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849
            VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA
Sbjct: 904  VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 963

Query: 850  AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
            AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR
Sbjct: 964  AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023

Query: 910  TIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 969
            TIEGLRGPPPSGIATLVSGIAG     GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH
Sbjct: 1024 TIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 1078

Query: 970  ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1029
            ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS
Sbjct: 1079 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1138

Query: 1030 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1089
            THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF
Sbjct: 1139 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1198

Query: 1090 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1144
            ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
Sbjct: 1199 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  106 bits (265), Expect = 1e-22
 Identities = 188/960 (19%), Positives = 389/960 (40%), Gaps = 154/960 (16%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 128
            K +  L A+V+++ E+LE      AE  AK ++LE             ++ L +V++ K 
Sbjct: 912  KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971

Query: 129  ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
                    + E+ A L   + +  KE K   EA ++ ++++    D +   +  K   E+
Sbjct: 972  ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031

Query: 183  RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLKQLE----E 231
            + + L+  +E  K+ R+D      +L  DL++ +  I +  +D      +LK+ E    +
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091

Query: 232  QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
            QN++++D  V    L    K+   ++++L E    ELE  R  R ++++  S     ++E
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEE----ELEAERTARAKVEKLRSDLSRELEE 1147

Query: 292  LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
            + E+++ A GA  + +EM   R    ++  R+L E     EA       L++   ++  E
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1204

Query: 351  LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
            L EQ+D      ++ +K     +  + D    +++  +  A+L+ V+R L +Q      +
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264

Query: 411  QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 460
             ++      DF  + A+ +     +  +L + E  ++Q  R     T  M D        
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE 1324

Query: 461  -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 501
                   +       HDC L+             + R++ KA     Q + K+E    + 
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384

Query: 502  CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 557
              E    +    ++L  A   V ++    S L+ T HR ++ +    VDV ++  +    
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1443

Query: 558  MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 616
            +   +R+ D  L E   K +  ++       +A      L+ +  A +      +  +H+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1497

Query: 617  KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 675
            +  +     +  E+  L   L +GG+   ++  + + LE    +++   ++    +   +
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557

Query: 676  APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 725
               + A L F            +  + +   +++   VV  LQ    A  +    +   +
Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617

Query: 726  GLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPS 785
              +   L E+  + S       ++   + ++   ++L  T  +L  A++  +   E    
Sbjct: 1618 KKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675

Query: 786  KPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL--- 842
                VE R   L+AE          LE+   V+++ ++S K+  +EL E + R+ LL   
Sbjct: 1676 ----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721

Query: 843  -------EKKLDS--------------AAKDADERIEKVQT----------RLEETQALL 871
                   +KK++S                ++A+E+ +K  T          + ++T A L
Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781

Query: 872  RKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTIEGLRG 916
             + +K  E+T+  LQ  +D+               LEA   EL+  L ++ KR  E ++G
Sbjct: 1782 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKG 1841



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 163/845 (19%), Positives = 342/845 (40%), Gaps = 103/845 (12%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKSKMQEQQADL 138
            KE   ++ +   ++E LE    +R E + K+  L  EK+ +QL+   E     Q+   D 
Sbjct: 849  KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-----QDNLNDA 903

Query: 139  QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
            + R  +  K  K  LEAK + M E  +  + +      K+        L+ E   LK+ +
Sbjct: 904  EERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLEDECSELKKDI 956

Query: 199  DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
            D    DLE+  A++E++     A+  ++K L E+ A L + + ++    + EK      +
Sbjct: 957  D----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TKEK------K 999

Query: 259  KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLE 317
             L E   Q L+ ++ + +++   LS+++  +++  + ++ +L  E+ V M  +R    LE
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV-NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058

Query: 318  EKVRELRETVGDLEAMNEMNDELQ--ENARETELELREQ---LDMAGARVREAQKRVEAA 372
              ++  +E++ DLE     ND+LQ  E  ++ E ++ +Q   ++       + QK+++  
Sbjct: 1059 GDLKLTQESIMDLE-----NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113

Query: 373  QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 432
            Q  + + ++ ++  R   A ++ +  +L+ + E   ER ++    T    ++    K   
Sbjct: 1114 QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEMNKKRE 1170

Query: 433  KAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 490
               +   R +E A  Q     + L     DS    G   D +  +        K +L ++
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQKLEKE 1222

Query: 491  QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 550
            +++ K EL +  S    +  A       +  L    +  +  L   + +L+  +     K
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAK 1281

Query: 551  VGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTM 610
            + +   E++      + LI  L + +L  T  +E L + +            E+      
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL------------EEEGKAKN 1329

Query: 611  QLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR 670
             LA  ++  +   D +           Q  +E    A L R L  + S++ Q+  K    
Sbjct: 1330 ALAHALQSARHDCDLLRE---------QYEEETEAKAELQRVLSKANSEVAQWRTKYE-- 1378

Query: 671  MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA 730
               TDA           Q ++ L + +K L   +   +E   A     + L + +  L  
Sbjct: 1379 ---TDA----------IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425

Query: 731  ALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 790
             +E+L            +++  +  R    IL     K   +  E E   +   S    +
Sbjct: 1426 EIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483

Query: 791  ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA 850
                 A    +   E    + ++ +  I +L + L   G+ + E    L  + K+L+   
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE----LEKVRKQLEVEK 1539

Query: 851  KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRT 910
             +    +E+ +  LE  +  + + + EF +    ++A+I++  AEK E  ++     +R 
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHQRV 1595

Query: 911  IEGLR 915
            ++ L+
Sbjct: 1596 VDSLQ 1600



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 178/884 (20%), Positives = 366/884 (41%), Gaps = 134/884 (15%)

Query: 78   SPSKEEEGLRAQVRDLEEKLET-----LRLKRAEDKAK---------LKELEKHKIQLEQ 123
            S SK +  L  QV DLE  LE      + L+RA+ K +         + +LE  K+QLE+
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080

Query: 124  --------VQEWKSKMQEQQA---DLQRRLKEAR---KEAKEALEAKER----------- 158
                    + +  SK++++Q     LQ++LKE +   +E +E LEA+             
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140

Query: 159  YMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSD 218
               E+ + ++ +E A     +  E  +  + E + ++  ++E T   E   A + +K +D
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200

Query: 219  GAASSYQ----LKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE-VVRQ 273
              A   +    L++++++  + K       D  +S  ++ +K +  +EK ++ LE    +
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260

Query: 274  QRERLQE----------ELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVREL 323
             R +L+E          + ++ ++   EL  Q++     E ++  LT   L+  +++ +L
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK---EALISQLTRGKLSYTQQMEDL 1317

Query: 324  -RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQT 382
             R+   + +A N +   LQ    + +L LREQ +       E Q+ +  A   VA ++  
Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKANSEVAQWRT- 1375

Query: 383  IKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
              KY     Q T  L++  ++L  + + + E       E  + K    E   H    E+E
Sbjct: 1376 --KYETDAIQRTEELEEAKKKLAQRLQDAEEAV-----EAVNAKCSSLEKTKHRLQNEIE 1428

Query: 439  LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFEL 498
               ++V ++N   + L         +   + D +L           AE  +K  + + EL
Sbjct: 1429 DLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWKQKYEESQSEL 1469

Query: 499  SENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEM 558
              +  E    R  + E          SL  L+ T  R    L +   D+ +++G    E 
Sbjct: 1470 ESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLTEQLG----EG 1521

Query: 559  SAHERSLDFLIELLHKDQLDETVNVEP------------LTKAIKYYQHLYSIH--LAEQ 604
              +   L+ + + L  ++L+    +E             L   +++ Q    I   LAE+
Sbjct: 1522 GKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581

Query: 605  PEDCTMQLADH---IKFTQSALDCMSV---EVGRLRAFLQGGQEATDIALLLRDLETSCS 658
             E+      +H   +   Q++LD  +    EV R++  ++G  +  ++ + L       +
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEIQLSHANRMAA 1639

Query: 659  DIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL- 717
            + ++  K ++  +  T    +  A+     + + +    +    + A L+E+ A   Q  
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1698

Query: 718  -IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 776
                LAE E  L+   E +      Q+  + ++S     ++  + L    +++  A+QE 
Sbjct: 1699 RSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750

Query: 777  EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 836
                E+         + A  L+ E   +  L    ++ E  IK+L+  L  + E+++   
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-EAEQIALKG 1809

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 880
             +  L  +KL++  ++ +  +E  Q R  E+   +RK E+  +E
Sbjct: 1810 GKKQL--QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 65/310 (20%), Positives = 132/310 (42%), Gaps = 58/310 (18%)

Query: 98   ETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE 157
            E LR+K+  +     +L + +IQL       ++ Q+Q   LQ  LK+ + +  +A+ A +
Sbjct: 1612 EVLRVKKKMEG----DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667

Query: 158  RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS 217
               E +A              + E R   LQ E+E L+  V++     ++ + E+ E   
Sbjct: 1668 DLKENIA--------------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE--- 1710

Query: 218  DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER 277
                +S +++ L  QN            L + +K+    L +L  +  + ++  R   E+
Sbjct: 1711 ----TSERVQLLHSQNT----------SLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756

Query: 278  LQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE--------------- 322
             ++ ++ A    +ELK++ D +   E M + +     +L+ ++ E               
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816

Query: 323  ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
                +RE  G+LEA  + N E  +  R++E  ++E       +  E +K +   Q+ V  
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDKKNLLRLQDLVDK 1872

Query: 379  YQQTIKKYRQ 388
             Q  +K Y++
Sbjct: 1873 LQLKVKAYKR 1882



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 49/276 (17%)

Query: 93   LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 141
            L+ +LE LR  +++ E   KL E E      ++QL   Q       K KM+     LQ  
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            ++EA +E + A E  ++ + + A  A+ ++         E   ++++Q ++ L+ R+DE 
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1802

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
                     +I  KG          KQL++  AR+++    +     +E++ + +  K M
Sbjct: 1803 E--------QIALKGGK--------KQLQKLEARVRE----LEGELEAEQKRNAESVKGM 1842

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN------ 315
             K  + ++ +  Q E  ++ L + +  +D+L+ +V A     E  E   + NL+      
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902

Query: 316  ------------LEEKVRELRETVGDLEAMNEMNDE 339
                         E +V +LR    D+ A  +M+DE
Sbjct: 1903 HELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDE 1938



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 5/172 (2%)

Query: 734  ELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELR 793
            +L FK    +    +      +++    +  T+ K     +E E        +   ++L+
Sbjct: 833  KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892

Query: 794  AAALRAEITDAEGLGLKLEDR----ETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849
              A +  + DAE    +L       E  +KE+ + L+ + E  +E   +   LE +    
Sbjct: 893  VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952

Query: 850  AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
             KD D+ +E    ++E+ +     K K   E M  L   I +L  EK  L++
Sbjct: 953  KKDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 190/965 (19%), Positives = 388/965 (40%), Gaps = 164/965 (16%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 128
            K +  L A+V+++ E+LE      AE  AK ++LE             ++ L +V++ K 
Sbjct: 910  KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKH 969

Query: 129  ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
                    + E+ A L   + +  KE K   EA ++ ++++    D +   T  K   E+
Sbjct: 970  ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029

Query: 183  RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLK----QLEE 231
            + + L+  +E  K+ R+D      +L  DL++ +  I +  +D      +LK    +L  
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089

Query: 232  QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
             NAR++D     + L S  +++  +LQ  +E+  +ELE  R  R ++++  S     ++E
Sbjct: 1090 LNARIEDE----QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145

Query: 292  LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
            + E+++ A GA  + +EM   R    ++  R+L E     EA       L++   ++  E
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1202

Query: 351  LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
            L EQ+D      ++ +K     +  + D    +++  +  A+L+ + R L +Q      +
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262

Query: 411  QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 460
             ++      D   + A+ +     +  +L + E  ++Q  R     T  + D        
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322

Query: 461  -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 501
                   +       HDC L+             + R++ KA     Q + K+E    + 
Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382

Query: 502  CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 557
              E    +    ++L  A   V ++    S L+ T HR ++ +    VDV ++  +    
Sbjct: 1383 TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1441

Query: 558  MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 616
            +   +R+ D  L E   K +  ++       +A      L+ +  A +      +  +H+
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1495

Query: 617  KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 675
            +  +     +  E+  L   L   G+   ++  + + LE    +++   ++    +   +
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555

Query: 676  APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 725
               + A L F            +  + +   +++   VV  LQ    A  +     + NE
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR-----SRNE 1610

Query: 726  GLLVAA-----LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
             L V       L E+  + S       ++   + ++   ++L  T  +L  A++  +   
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E        VE R   L+AE          LE+   V+++ ++S K+  +EL E + R+ 
Sbjct: 1669 ENIAI----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQ 1714

Query: 841  LL----------EKKLDS--------------AAKDADERIEKVQT----------RLEE 866
            LL          +KK+D+                ++A+E+ +K  T          + ++
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774

Query: 867  TQALLRKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTI 911
            T A L + +K  E+T+  LQ  +D+               LEA   EL+  L ++ KR  
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834

Query: 912  EGLRG 916
            E ++G
Sbjct: 1835 ESVKG 1839



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 177/854 (20%), Positives = 346/854 (40%), Gaps = 105/854 (12%)

Query: 74   PPLPSPSKEEE--GLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKS 129
            P L S  +E+E   ++ +   L+E LE    +R E + K+  L  EK+ +QL+   E   
Sbjct: 838  PLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--- 894

Query: 130  KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
              Q+  AD + R  +  K  K  LEAK + M E  +  + +      K+        L+ 
Sbjct: 895  --QDNLADAEERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLED 945

Query: 190  EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
            E   LK  +D    DLE+  A++E++     A+  ++K L E+ A L + + ++    + 
Sbjct: 946  ECSELKRDID----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TK 994

Query: 250  EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
            EK      + L E   Q L+ ++ + +++   L++A+  +++  + ++ +L  E+ V M 
Sbjct: 995  EK------KALQEAHQQALDDLQAEEDKV-NTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047

Query: 310  TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARVREAQK 367
             +R    LE  ++  +E++ DLE   +  DE +   ++ EL  L  +++   A   + QK
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDE-RLKKKDFELNALNARIEDEQALGSQLQK 1106

Query: 368  RVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAE 427
            +++  Q  + + ++ ++  R   A ++ +  +L+ + E   ER ++    T    ++   
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEM 1163

Query: 428  TKAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKA 485
             K      +   R +E A  Q     + L     DS    G   D +  +        K 
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQ 1215

Query: 486  ELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSV 545
            +L +++++ K EL +  S    +  A          L       Q   HR +   +Q SV
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----QMNEHRSKAEETQRSV 1270

Query: 546  -DVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+  +   L  E     R LD           ++   +  LT+    Y         +Q
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLD-----------EKEALISQLTRGKLTY--------TQQ 1311

Query: 605  PEDCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR 661
             ED   QL + +K   +   AL     +   LR   Q  +E    A L R L  + S++ 
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE--QYEEETEAKAELQRVLSKANSEVA 1369

Query: 662  QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 721
            Q+  K       TDA           Q ++ L + +K L   +   +E   A     + L
Sbjct: 1370 QWRTKYE-----TDA----------IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414

Query: 722  AENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAE 781
             + +  L   +E+L            +++  +  R    IL     K   +  E E   +
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 782  RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL 841
               S    +     A    +   E    + ++ +  I +L + L   G+ + E    L  
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE----LEK 1528

Query: 842  LEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            + K+L++   +    +E+ +  LE  +  + + + EF +    ++A+I++  AEK E  +
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEME 1584

Query: 902  RLNSQSKRTIEGLR 915
            +      R ++ L+
Sbjct: 1585 QAKRNHLRVVDSLQ 1598



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 166/832 (19%), Positives = 334/832 (40%), Gaps = 101/832 (12%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E   L A++ D +     L+ K  E +A+++ELE+   +LE  +  ++K+++ ++DL R 
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEE---ELEAERTARAKVEKLRSDLSRE 1142

Query: 142  LKEARKEAKEA-------LEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEVEA 193
            L+E  +  +EA       +E  ++   E       +E ATL  E  A    +     V  
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            L E++D    +L+ +K ++E++ S+       +    EQ  + K  L +M      +  E
Sbjct: 1203 LGEQID----NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258

Query: 254  HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            H   +   E+  + +  +  QR +LQ E  +    +DE           E ++  LT   
Sbjct: 1259 H---RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE----------KEALISQLTRGK 1305

Query: 314  LNLEEKVREL-RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
            L   +++ +L R+   +++A N +   LQ    + +L LREQ +       E Q+ +  A
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKA 1364

Query: 373  QETVADYQQTIKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
               VA ++    KY     Q T  L++  ++L  + + + E       E  + K    E 
Sbjct: 1365 NSEVAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAV-----EAVNAKCSSLEK 1416

Query: 429  KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELI 488
              H    E+E   ++V ++N   + L         +   + D +L           AE  
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWK 1457

Query: 489  RKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY 548
            +K  + + EL  +  E    R  + E          SL  L+ T  R    L +   D+ 
Sbjct: 1458 QKYEESQSELESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLT 1513

Query: 549  KKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 598
            +++GS          +  ++ A +  L   +E        E   +  L   +++ Q    
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAE 1571

Query: 599  IH--LAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRAFLQGGQEATDIALLL 650
            I   LAE+ E+      +H++   S    +  E        R++  ++G  +  ++ + L
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG--DLNEMEIQL 1629

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
                   ++ ++  K ++  +  T    +  A+     + + +    +    + A L+E+
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688

Query: 711  AAAAAQL--IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNK 768
             A   Q      LAE E  L+   E +      Q+  + ++S     ++    L     +
Sbjct: 1689 RAVVEQTERSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMDADLSQLQTE 1740

Query: 769  LATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIK 828
            +  A+QE     E+         + A  L+ E   +  L    ++ E  IK+L+  L  +
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-E 1799

Query: 829  GEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 880
             E+++    +  L  +KL++  ++ +  +E  Q R  E+   +RK E+  +E
Sbjct: 1800 AEQIALKGGKKQL--QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 85/429 (19%), Positives = 188/429 (43%), Gaps = 71/429 (16%)

Query: 84   EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQRRL 142
            E  + + ++L+E++  L  +       + ELEK + QLE +  E +S ++E +A L+   
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555

Query: 143  KEARKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERV--- 198
             +  +   E  + K     ++A+  + +E A  +   + +    SL  E  +  E +   
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615

Query: 199  DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL--SSSEKQEHVK 256
             ++  DL  ++ ++       A +  Q+K L+   + LKD  +++ D   ++ + +E++ 
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLLKDTQIQLDDAVRANDDLKENIA 1672

Query: 257  L----QKLMEKKNQELEVVRQQRER--------------------------------LQE 280
            +      L++ + +EL  V +Q ER                                +  
Sbjct: 1673 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732

Query: 281  ELSQAESTIDELKEQ------------VDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 328
            +LSQ ++ ++E  ++             DAA+ AEE+ +   D + +LE   + + +T+ 
Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIK 1791

Query: 329  DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ----ETVADYQQTIK 384
            DL+      DE ++ A +     ++QL    ARVRE +  +EA Q    E+V   +++ +
Sbjct: 1792 DLQ---HRLDEAEQIALKGG---KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845

Query: 385  KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 444
            + ++LT   ++  + L   Q+  +  + Q   + +  + + AE +A+    +    Q E+
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQD--LVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903

Query: 445  AQANRHMSL 453
             +A     +
Sbjct: 1904 DEAEERADI 1912



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 61/266 (22%), Positives = 122/266 (45%), Gaps = 32/266 (12%)

Query: 93   LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 141
            L+ +LE LR  +++ E   KL E E      ++QL   Q       K KM    + LQ  
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            ++EA +E + A E  ++ + + A  A+ ++         E   ++++Q ++ L+ R+DE 
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
                     +I  KG          KQL++  AR+++    + +   +E++ + +  K M
Sbjct: 1801 E--------QIALKGGK--------KQLQKLEARVRE----LENELEAEQKRNAESVKGM 1840

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
             K  + ++ +  Q E  ++ L + +  +D+L+ +V A     E  E   + NL+   KV+
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1900

Query: 322  -ELRETVGDLEAMNEMNDELQENARE 346
             EL E     +      ++L+  +R+
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRD 1926



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 128/633 (20%), Positives = 250/633 (39%), Gaps = 76/633 (12%)

Query: 296  VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 355
            +D+  GAE+++  L   +   +    ++    G L  + EM DE     R + +  R Q 
Sbjct: 736  IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE-----RLSRIITRIQA 790

Query: 356  DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
               G   R   K++   ++++   Q  I+ +  +                 S ER+++  
Sbjct: 791  QSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMA 850

Query: 416  PETFDF-KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLV 474
                +F ++K A  K+ A+  E+E + + + Q    + L      D+      +  C  +
Sbjct: 851  SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQL 908

Query: 475  LLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLH 534
            +    +L  K + + ++ +++ E++   +E    +    ++ S     +  L L  A + 
Sbjct: 909  IKNKIQLEAKVKEMNERLEDEEEMN---AELTAKKRKLEDECSELKRDIDDLELTLAKVE 965

Query: 535  RYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFL------IELLHKDQLD----ETVNVE 584
            + +HA          KV +L  EM+  +  +  L      ++  H+  LD    E   V 
Sbjct: 966  KEKHATEN-------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018

Query: 585  PLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEAT 644
             LTKA         + L +Q +D    L    K        + +++ R +  L+G  + T
Sbjct: 1019 TLTKA--------KVKLEQQVDDLEGSLEQEKK--------VRMDLERAKRKLEGDLKLT 1062

Query: 645  DIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVV 704
              +++  DLE     + +  KK    +   +A  I    A G Q+   L    K L   +
Sbjct: 1063 QESIM--DLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKL----KELQARI 1115

Query: 705  AVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIS 764
              L+E   A     A + +    L   LEE++ +  E    T             ++ I 
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT-------------SVQIE 1162

Query: 765  TMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEG-LGLKLEDRETVIKELKK 823
               K     Q+   D E    +    E  AAALR +  D+   LG ++++ + V ++L+K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219

Query: 824  SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 883
                   E SE  + L  +   ++   K A   +EK+   LE+     R K +E + +++
Sbjct: 1220 -------EKSEFKLELDDVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271

Query: 884  ALQADIDQLEAEKAELKQRLNSQSKRTIEGLRG 916
             L +   +L+ E  EL ++L+ +     +  RG
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 34/133 (25%), Positives = 67/133 (50%), Gaps = 13/133 (9%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKM 131
            L    K+ + L A+VR+LE +LE  + + AE    +++ E+       Q E+ ++   ++
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864

Query: 132  QEQQADLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQE 190
            Q+    LQ ++K  +++A+EA        EE A+T          + + AEERA+  + +
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEA--------EEQANTNLSKFRKVQHELDEAEERADIAESQ 1916

Query: 191  VEALKERVDELTT 203
            V  L+ +  ++ T
Sbjct: 1917 VNKLRAKSRDIGT 1929


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 247/1088 (22%), Positives = 426/1088 (39%), Gaps = 149/1088 (13%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLK----RAEDKAKLKELEKHKIQLEQ----VQEW 127
            L    ++ E      R+ +E+LE LRL+    R   +  L+  E+ +  LEQ    ++  
Sbjct: 769  LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828

Query: 128  KSKMQEQQADLQRRL-------KEARKEAKEALEAKERYMEEMADTAD-----AIEMATL 175
            +S++QEQ A L R+L       ++AR+EA+  +EA ER   E    A      A+++   
Sbjct: 829  RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888

Query: 176  DKE--MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQN 233
            ++E     E A  L+ E EAL+  + E+   L  L+A  E+  ++G A     + L  + 
Sbjct: 889  EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948

Query: 234  ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR-------ERLQEELSQAE 286
            A L+  ++  ++ +S +K+  +  QKL++ + +    +R+QR       +RLQ E   A 
Sbjct: 949  AGLRQQIIATQEKASLDKE--LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW 1006

Query: 287  STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 346
              ++  + Q+ + L   E  E+L      LE +  EL E +  L+   +    L E+ ++
Sbjct: 1007 RELEAERAQLQSQL-QREQEELLA----RLEAEKEELSEEIAALQQERDEGLLLAESEKQ 1061

Query: 347  TELELREQLDMA------GAR-------------VREAQKRVEAAQETVADYQQTIKKYR 387
              L L+E    A      G R              R+AQ R E  + TV           
Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV----------N 1111

Query: 388  QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQA 447
             LT+ L+D+  +      A  +  ++   +  D   +       A+ +  +LR +E A+ 
Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171

Query: 448  NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERP 506
                 LL A      LR   +                 E+ R++A E +  L E   ER 
Sbjct: 1172 GLRRELLEA---QRKLRESQE---------------GREVQRQEAGELRRSLGEGAKERE 1213

Query: 507  GLRGAAGEQLSF---AAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHER 563
             LR +  E  S    A     SL L      +    L +    V K+ G L   +   ER
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273

Query: 564  S-LDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPED----CTMQLADHIKF 618
            S L+   EL    +  + ++ E      +  +    + L E+ E      T+ L   +  
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333

Query: 619  TQSALDCM--SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDA 676
             +++L+ M   ++V + +   Q G+  T    LL  LE +    +Q     R    G + 
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR----GLEL 1389

Query: 677  PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELA 736
              + AA A   ++   L         + A   E+A    Q  A  A+  GL  A    L 
Sbjct: 1390 K-LEAARAEAAELGLRLSAAEGRAQGLEA---ELARVEVQRRAAEAQLGGLRSALRRGLG 1445

Query: 737  F-----KASEQIYGTPS-SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 790
                   A   + G+P+  +P E   +  N   ST+     +       A  P S     
Sbjct: 1446 LGRAPSPAPRPVPGSPARDAPAEGSGEGLN-SPSTLECSPGSQPPSPGPATSPASPDLDP 1504

Query: 791  ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---D 847
            E    ALR  + +      + ++  T    L + L     E   A  R   L+K +   +
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564

Query: 848  SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD-------ALQADIDQLEAEKAELK 900
             A +  D R+  VQ  L   +  +R+ E+E   T+D       +LQA   +L A + ++ 
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624

Query: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
            +   +++K  +EG +      +    S     E QR ++ G+   S  G   + D     
Sbjct: 1625 KMKANETK--LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG---LSDRE--- 1676

Query: 961  QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
             Q  A++  +  LQ +   +  +++KA    L    V +L+      E   GAL  K   
Sbjct: 1677 AQAQALQDRVDSLQRQ---VADSEVKAGTLQLT---VERLNGALAKVEESEGALRDKVRG 1730

Query: 1021 LLETLNQL-----STHTHVVDITRTSPAAKSPSAQLMEQV-----------AQLKSLSDT 1064
            L E L Q      ST    + + +   A +     L E++            Q  SL + 
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790

Query: 1065 VEKLKDEV 1072
            V+ L+ EV
Sbjct: 1791 VQTLRGEV 1798



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 209/947 (22%), Positives = 365/947 (38%), Gaps = 134/947 (14%)

Query: 14   RRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAV 73
            R P P R +S G  G S   GPS + S       + ST A    A               
Sbjct: 491  RTPSPPRRSSPG-RGRSPRRGPSPACS-------DSSTLALIHSA--------------- 527

Query: 74   PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
              L     + + +R +    ++ L TLR + ++ +++ + LE+   QL+++++      +
Sbjct: 528  --LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEE---QLQRLRDKTDGAMQ 582

Query: 134  QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
               D QR ++  R        A E    E ++ A ++++A       +++AE L+QE E 
Sbjct: 583  AHEDAQREVQRLRS-------ANELLSREKSNLAHSLQVA-------QQQAEELRQEREK 628

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGA-------ASSYQLKQLEEQNARLKDALVRMRDL 246
            L+   +EL    + L+ E E+   DGA        S  QL+QLE + + L   LV +R+ 
Sbjct: 629  LQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
             S    +   LQ   EK      + + +  R++ ELS  +   +E   Q D+      + 
Sbjct: 689  LSRATLQRDMLQ--AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ-DSLSKLSALN 745

Query: 307  EMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETE---LELREQLDMAGARVR 363
            E L    L+L   V +L E    L+      ++    ARE +    ELR + ++A   + 
Sbjct: 746  ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLE 805

Query: 364  EAQKRVEAAQETVADYQQTIKKYR-QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
             + +  E AQE +     T++  R QL   L  ++R+L+ +++   + ++          
Sbjct: 806  GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR---------- 855

Query: 423  IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
                E +   +A+E   R+ E A A  H  L    +     R G         L + +  
Sbjct: 856  ----EAQRQVEALERAAREKE-ALAKEHAGLAVQLVAAE--REGRTLSEEATRLRLEKEA 908

Query: 483  CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFA--------AGLVYSLSLLQATLH 534
             +  L   Q Q    L++  + R  L  A G+ L  A        AGL   +   Q    
Sbjct: 909  LEGSLFEVQRQ----LAQLEARREQLE-AEGQALLLAKETLTGELAGLRQQIIATQEKAS 963

Query: 535  RYEHALSQCSVDVYKKV-GSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 593
              +  ++Q  V   ++   SL  + +AHE  L  L         +       L   ++  
Sbjct: 964  LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023

Query: 594  QHLYSIHLAEQPEDCTMQLADHIKFTQSALD--CMSVEVGRLRAFLQGGQEATDIALLLR 651
            Q      L  + E    +L++ I   Q   D   +  E  + +A      E T ++  L 
Sbjct: 1024 QEELLARLEAEKE----ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079

Query: 652  DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
                S + I    ++ +R            A +   Q   T+      L  + A  +E A
Sbjct: 1080 GTRHSLATISLEMERQKR-----------DAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128

Query: 712  AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLAT 771
            AA AQ +  L E    L    +    +A E             LR    +L    + L  
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEE-------------LRTQLRLLEDARDGLRR 1175

Query: 772  AMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETVIKELKK---S 824
             + E +                A  LR  +     + E L    E+  + +K+ +    S
Sbjct: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235

Query: 825  LKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA 884
            LK+  E+  +   +L+LLE+   +  K+A E    +Q  +E ++   R++ +E    M  
Sbjct: 1236 LKLANEDKEQ---KLALLEEARTAVGKEAGELRTGLQ-EVERSRLEARRELQELRRQMKM 1291

Query: 885  LQADIDQLEAEKAELKQRL------NSQSKRTIEGLRGPPPSGIATL 925
            L ++  +L  E AEL+ RL        +S+R   GLR     G A+L
Sbjct: 1292 LDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 191/926 (20%), Positives = 351/926 (37%), Gaps = 122/926 (13%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            +E E LR Q+R LE+  + LR +  E + KL+E           QE +   +++  +L+R
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRES----------QEGREVQRQEAGELRR 1203

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES----LQQEVEALKE 196
             L E  KE     EA  R  EE+       E   +  ++A E  E     L++   A+ +
Sbjct: 1204 SLGEGAKER----EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259

Query: 197  RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD-------LSSS 249
               EL T L+ ++    E   +      Q+K L+ +N RL   L  ++            
Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319

Query: 250  EKQEHVKLQKLMEKKNQELEVVRQQ----RERLQEELSQAESTIDELKEQVDAALGAE-E 304
             ++E + L++ + K    LEV+RQ+    + +LQE+  +  +    L   ++ A G E +
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379

Query: 305  MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
             ++      L LE    E  E    L A       L+      E++ R      G  +R 
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRS 1438

Query: 365  AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP---PETFDF 421
            A +R        +   + +       A  +     L +          QPP   P T   
Sbjct: 1439 ALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP- 1497

Query: 422  KIKFAETKAHAKAIEMELRQM--EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMP 479
                A      +A+   LR+   E+  A R    L                       + 
Sbjct: 1498 ----ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTS-----------------ALN 1536

Query: 480  RLICKAELIRKQAQEKF-ELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEH 538
            R + + E  R  A  +  +L +  +E    R +   +LS   G+   L+L + ++ R E 
Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEESVRRSER 1593

Query: 539  ALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 598
               + ++D   +V +L   + A E  L    E + K + +ET  +E   + +K       
Sbjct: 1594 E-RRATLD---QVATLERSLQATESELRASQEKISKMKANET-KLEGDKRRLK------- 1641

Query: 599  IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLLRDLETSC 657
              + +  E  T++L    +  +  L    + +    A  Q  Q+  D +   + D E   
Sbjct: 1642 -EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700

Query: 658  SDIRQFCKKIRRRMPGTDAP---------GIPAALAFGPQVSDTLLDCRKHLTWVVA--- 705
              ++   +++   +   +           G+  ALA      ++  D   HL   +    
Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACE 1760

Query: 706  ----VLQEVAAAAAQLIAPLAENEGLL----------VAALEELAFKASEQIYGTPSSSP 751
                VLQE   AA Q ++   +    L          VA LE    +A  Q+        
Sbjct: 1761 HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL-----QQL 1815

Query: 752  YECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKL 811
             E LRQ      + +N +     E     ER  S    ++   A L AE  + E   L+L
Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGS----LQRALAQLEAEKREVERSALRL 1871

Query: 812  EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA-- 869
            E     ++     ++ +     E  VRLS  + +LD     A+  + + Q ++++ +A  
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931

Query: 870  -LLRKKEKEFEETMDA------LQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI 922
             +L +     +  +DA      LQ ++++L + +A+ ++ L ++ +   + +RG     +
Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-V 1990

Query: 923  ATLVSGIAGEEQQRGAIPGQAPGSVP 948
            +TL  G   +E +R + P   P   P
Sbjct: 1991 STL-KGQLQQELRRSSAPFSPPSGPP 2015



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 98/439 (22%), Positives = 187/439 (42%), Gaps = 41/439 (9%)

Query: 21   PASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPS 80
            PA   V G+ +   P+  +  G    + PST   +P + P  P P  TSP       SP 
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEG---LNSPSTLECSPGSQPPSPGPA-TSPA------SPD 1501

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
             + E +R  +R+  ++L + + +R E + +   L +   ++E  ++  +    Q      
Sbjct: 1502 LDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVA 1561

Query: 141  RLKEARKEAKEAL---EAKERYMEEMADTADAIEMATLDKEMAEERA-ESLQQEVEALKE 196
              +EAR+     L   +A+    EE    ++    ATLD+    ER+ ++ + E+ A +E
Sbjct: 1562 ESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQE 1621

Query: 197  RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR-DLSSSEKQEHV 255
            ++ ++  +   L+ +         AS  +  +LE Q   L+  L R R  LS  E Q   
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681

Query: 256  ------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV----DAALGAEEM 305
                   LQ+ +     +   ++   ERL   L++ E +   L+++V    +A   +   
Sbjct: 1682 LQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741

Query: 306  VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365
            +    D+NL+L+   + L     D + + E  D     AR+   E R+Q    G      
Sbjct: 1742 LNSTRDKNLHLQ---KALTACEHDRQVLQERLDA----ARQALSEARKQSSSLG------ 1788

Query: 366  QKRVEAAQETVADYQ-QTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIK 424
             ++V+  +  VAD + Q ++   QL   L++V R+    + A++   Q+   E    + +
Sbjct: 1789 -EQVQTLRGEVADLELQRVEAEGQL-QQLREVLRQRQEGEAAALNTVQKLQDERRLLQER 1846

Query: 425  FAETKAHAKAIEMELRQME 443
                +     +E E R++E
Sbjct: 1847 LGSLQRALAQLEAEKREVE 1865



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 104/509 (20%), Positives = 209/509 (41%), Gaps = 90/509 (17%)

Query: 15   RPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPST-PAQTPLAAPIIPTPVLTSPGA- 72
            RP P  PA    A  S     S S       S  PS  PA +P +  + P  V  +    
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF 1514

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ--------- 123
            +  L S  +E + LR Q   L  +L  +  +R    ++ ++L+K   + E+         
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574

Query: 124  --------VQEWKSKMQEQQ--------ADLQRRLKEARKEAKEA-------------LE 154
                    +QE   +  E++        A L+R L+    E + +             LE
Sbjct: 1575 SGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLE 1634

Query: 155  AKERYMEEMADTADA------IEMATLDKEMAEER---------AESLQQEVEALKERVD 199
              +R ++E+ D +++      ++  +L+ E+   R         A++LQ  V++L+ +V 
Sbjct: 1635 GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694

Query: 200  ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
            +       L+  +E      A        L ++   L +AL +     +S + +++ LQK
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754

Query: 260  LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
             +     + +V++++ +  ++ LS+A      L EQV    G    +E+   + +  E +
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL---QRVEAEGQ 1811

Query: 320  VRELRETV-----GDLEAMN---EMNDE----------LQENARETELELRE------QL 355
            +++LRE +     G+  A+N   ++ DE          LQ    + E E RE      +L
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871

Query: 356  DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
            +     +R    +VE  +E +  ++ T++    L+A    ++R LT  +    E Q+Q  
Sbjct: 1872 EKDRVALRRTLDKVE--REKLRSHEDTVR----LSAEKGRLDRTLTGAELELAEAQRQ-- 1923

Query: 416  PETFDFKIKFAETKAHAKAIEMELRQMEV 444
             +  + ++   E       +E++ +Q ++
Sbjct: 1924 IQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 177/868 (20%), Positives = 343/868 (39%), Gaps = 115/868 (13%)

Query: 64  TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ 123
           +PVL     +  L S  +E + L+ ++  +E+ L   R +R E   K   + +   +LEQ
Sbjct: 64  SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQ 120

Query: 124 VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER 183
               +    E Q        E R   ++++E + +  EE A     ++     ++   + 
Sbjct: 121 ALRLEPGELETQ--------EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL 172

Query: 184 AESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM 243
            + LQ ++   K+R  EL   L     E+E+          Q  +  E +  L+ AL+R+
Sbjct: 173 VQRLQGKILQYKKRCSELEQQLLERSGELEQ----------QRLRDTEHSQDLESALIRL 222

Query: 244 RD---LSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQEELSQAESTIDELK 293
            +    S+S  Q +  L++ +++        ++++  V     R ++EL   E+     +
Sbjct: 223 EEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282

Query: 294 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ---ENARETELE 350
           E  +A    E        R L L  +V   R  V +++   E  D LQ   E AR +   
Sbjct: 283 ESFNAYFSNEH------SRLLLLWRQVVGFRRLVSEVKMFTE-RDLLQLGGELARTSRAV 335

Query: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
               L ++   +R A+ R EAA          ++K   L A L++  R+   +++   ++
Sbjct: 336 QEAGLGLS-TGLRLAESRAEAA----------LEKQALLQAQLEEQLRDKVLREKDLAQQ 384

Query: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 470
           Q Q   +  D   +  E     K +E +   +E  Q N+ ++     +    L+     +
Sbjct: 385 QMQSDLDKADLSARVTELGLAVKRLEKQ--NLEKDQVNKDLTEKLEALESLRLQEQAALE 442

Query: 471 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERP------GLRGAAGEQL-------- 516
                 L   L   A+ +   ++   +LS   SER        LRG +G++         
Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSG--SERTADASNGSLRGLSGQRTPSPPRRSS 500

Query: 517 -----------SFAAGLVYSLSLLQATLHRYEHALS------QCSVDVYKKVGSLYPEMS 559
                      S A     +L+L+ + LH+ +  +       + S D+   +     +  
Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560

Query: 560 AHERSLDFLIELLHKDQLDETVNV-EPLTKAIKYYQHLYSIHLAEQPE-----DCTMQLA 613
           +  R+L+  ++ L +D+ D  +   E   + ++  +    +   E+           Q A
Sbjct: 561 SERRALEEQLQRL-RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619

Query: 614 DHIKFTQSALDCMSVEVGRLRAFLQGGQE--ATDIALLLRDLETSCSDIRQFCKKIRRRM 671
           + ++  +  L     E+ R R  L+  QE    D A + R+LE S   + Q   + +R +
Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL--EGKRSV 677

Query: 672 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
              +   +  AL+      D L           A   EVA A  +  A   E E   ++ 
Sbjct: 678 LAKELVEVREALSRATLQRDML----------QAEKAEVAEALTKAEAGRVELE---LSM 724

Query: 732 LEELAFKASEQIYGTPSSSPYECLRQ---SCNILISTMNKLATAMQEGEYDAERPPSKPP 788
            +  A +AS Q   +  S+  E L Q     N L++ + +  +A+Q  +  AE+  +   
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784

Query: 789 PVELRAAALRAEITDA-EGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLD 847
             + R   LR E   A +GL   L   E   + L++ L     E S+   +L+ L ++L 
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844

Query: 848 SAAKDADERIEKVQTRLEETQALLRKKE 875
              ++ ++   + Q ++E  +   R+KE
Sbjct: 845 GREQELEQARREAQRQVEALERAAREKE 872



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 214/1026 (20%), Positives = 391/1026 (38%), Gaps = 153/1026 (14%)

Query: 189  QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
            QEVE   E V + T +  +L    +EKG  GA    Q  Q+    A +++ + R  +LS 
Sbjct: 9    QEVELTLETVIQ-TLESSVL---CQEKGL-GARDLAQDAQITSLPALIREIVTR--NLSQ 61

Query: 249  SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
             E    +   ++       L  ++++ + LQ+ELS+ E  + + + + D        V  
Sbjct: 62   PESPVLLPATEMAS-----LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE 116

Query: 309  LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
              ++ L LE    E +E  G +    E+  +LQE       +L+   +    + R+AQ  
Sbjct: 117  RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE---GQQRQAQ-L 172

Query: 369  VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
            V+  Q  +  Y+   K+  +L   L + + EL  Q+    E  Q         + +   +
Sbjct: 173  VQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229

Query: 429  KAHAKAIEMELRQMEVA-QANRHMSLLTAFMPDSFLRP---------------------- 465
             + A+   M   Q++ A  AN+ +S     + + + R                       
Sbjct: 230  ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289

Query: 466  GGDHDCVLVL----LLMPRLICKAELIRK----QAQEKFELSENCSERPGLRGAAGEQL- 516
              +H  +L+L    +   RL+ + ++  +    Q   +   +    +  GL  + G +L 
Sbjct: 290  SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349

Query: 517  -SFAAGLVYSLSLLQA---------TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
             S A   +   +LLQA          L   + A  Q   D+ K       ++SA    L 
Sbjct: 350  ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK------ADLSARVTELG 403

Query: 567  FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCM 626
              ++ L K  L++    + LT+ +   + L S+ L EQ     ++  D     Q+  D  
Sbjct: 404  LAVKRLEKQNLEKDQVNKDLTEKL---EALESLRLQEQ---AALETEDGEGLQQTLRDL- 456

Query: 627  SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFG 686
                   +A L   +    ++   R  + S   +R    +     P   +PG   +   G
Sbjct: 457  ------AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510

Query: 687  PQV----SDTLLDCRKHLTWVVAVLQEVAA---AAAQLIAPL------AENEGLLVAALE 733
            P      S TL      L      +Q++     A+  L+  L      +E+E     ALE
Sbjct: 511  PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESER---RALE 567

Query: 734  ELAFKASEQIYGT-----PSSSPYECLRQSCNILISTMNKLATAMQEGEYDA-----ERP 783
            E   +  ++  G       +    + LR +  +L    + LA ++Q  +  A     ER 
Sbjct: 568  EQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627

Query: 784  PSKPPPVELRAAALRAE------ITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANV 837
              +    ELR    R E      + D   +  +LE     +++L+    +  +EL E   
Sbjct: 628  KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687

Query: 838  RLS--LLEKKLDSAAK----DADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQ 891
             LS   L++ +  A K    +A  + E  +  LE +   LR +E   ++++  L A  + 
Sbjct: 688  ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNES 747

Query: 892  LEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPG 951
            L  +K +L  RL +Q +     L+G      A   + +A EEQ+R     +    V   G
Sbjct: 748  LAQDKLDL-NRLVAQLEEEKSALQGRQRQ--AEQEATVAREEQER-LEELRLEQEVARQG 803

Query: 952  LVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPA 1011
            L     +  Q   A+   +  L+HE S L+               +A+LS +  G E   
Sbjct: 804  LEGSLRVAEQAQEALEQQLPTLRHERSQLQE-------------QLAQLSRQLSGREQEL 850

Query: 1012 GALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDE 1071
                R+  + +E L + +     +       A      QL+    + ++LS+   +L+ E
Sbjct: 851  EQARREAQRQVEALERAAREKEALAKEHAGLA-----VQLVAAEREGRTLSEEATRLRLE 905

Query: 1072 VLKETVSQRPGATVPTDFATFPSSAFLRAKEEQ---QDDTVYMGKVTFSCAAGFGQRHRL 1128
              KE       A   + F      A L A+ EQ   +   + + K T +     G R ++
Sbjct: 906  --KE-------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA-GLRQQI 955

Query: 1129 VLTQEQ 1134
            + TQE+
Sbjct: 956  IATQEK 961



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 55/280 (19%), Positives = 113/280 (40%), Gaps = 37/280 (13%)

Query: 9    RKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLT 68
            R+    R    R A +     SSSLG       GE++  E            +       
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822

Query: 69   SPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 128
              G    L +  K    L+ + R L+E+L +L+   A+ +A+ +E+E+  ++LE      
Sbjct: 1823 QEGEAAALNTVQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE------ 1872

Query: 129  SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
                + +  L+R L +  +E   + E   R   E       +  A L+   A+ + + L+
Sbjct: 1873 ----KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE 1928

Query: 189  QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM-RDLS 247
             +V  L++       +++  + ++E               L+++  RL+ A  +  R L 
Sbjct: 1929 AQVVVLEQSHSPAQLEVDAQQQQLE---------------LQQEVERLRSAQAQTERTLE 1973

Query: 248  SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 287
            + E+    +++ L E+       V   + +LQ+EL ++ +
Sbjct: 1974 ARERAHRQRVRGLEEQ-------VSTLKGQLQQELRRSSA 2006


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 208/949 (21%), Positives = 367/949 (38%), Gaps = 154/949 (16%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-------KHKIQLEQVQEWKSKMQE 133
            +E+  L  +V +L+  +ET R ++ E +A++ ELE       +   + E+V + K ++QE
Sbjct: 643  REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702

Query: 134  QQADLQRRLK-------EARKEAKEALEAKERYMEEM-ADTADAIEMATLD-KEMAEERA 184
            Q   L+  LK       E ++ A +ALE ++R + E+ A+T   +E    + KE+ EERA
Sbjct: 703  QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762

Query: 185  -------------ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQL 229
                         E+ Q E E L+  + E        ++E E+   + AA    Y+  Q 
Sbjct: 763  GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822

Query: 230  EE--QNARLKDALVRMRDLSSSEKQEHVKLQKLMEK-----KNQELEVVRQQRERLQEEL 282
            EE    A  ++ L+ +++     +QE   LQ+  EK      + EL++ RQ     Q EL
Sbjct: 823  EEAQYGAMFQEQLMTLKEECEKARQE---LQEAKEKVAGIESHSELQISRQ-----QNEL 874

Query: 283  SQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQE 342
            ++  + +    +QV      E   + L D    L+EK+    + V  LE +     E QE
Sbjct: 875  AELHANLARALQQVQE---KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931

Query: 343  NARETELELREQLDMAGARVRE------------AQKRVEAAQETVADYQQTIKKYRQLT 390
             A     EL ++   AG R  E             Q  ++A +         +++ R   
Sbjct: 932  TASR---ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988

Query: 391  AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRH 450
               Q   +E   QQE  V R  Q   E    +   A  KA    +EM L+     Q    
Sbjct: 989  MESQGQQQEERGQQEREVARLTQ---ERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045

Query: 451  MSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERPGLR 509
             +L  A       + G D +   +  L    I + E +R+  ++ K +L++   E     
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105

Query: 510  GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERS---LD 566
            GA  E           L  L+A + + E    QC     ++  SL   + A   S    D
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLE---QQCQKQ-QEQADSLERSLEAERASRAERD 1161

Query: 567  FLIELLHKDQLDETVN--------VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLA---DH 615
              +E L + QL+E           +    + +  ++     H ++  ++   Q+A     
Sbjct: 1162 SALETL-QGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH-SKAEDEWKAQVARGRQE 1219

Query: 616  IKFTQSALDCMSVEVGRL-RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
             +   S +  +  EV  L R  L+   E+ ++  L+         + +  + ++      
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASN 1279

Query: 675  DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
             A     + A   +V     +  K       + QE+ + A +     AE  G  + A +E
Sbjct: 1280 SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER-----AEELGQELKAWQE 1334

Query: 735  LAFKASEQIYGTPSSSPYECLRQSCNILISTM---NKLATAMQEGEYDAER------PPS 785
              F+  + +      S  +    S   L+S +     L   +Q  +  AE+        S
Sbjct: 1335 KFFQKEQAL------STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388

Query: 786  KPPPVELRAAALRA--EITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---------- 833
            K     LRA  LRA  E+ +   L  K+ ++E   ++L+       E+LS          
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448

Query: 834  --------EANVRLSLLEKKLDSAAK-----------DADERIEKVQTRLEETQALLR-- 872
                     AN+    LE +LD A +           DA+ R+ +VQ   + T   L   
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508

Query: 873  ------------KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
                        ++ + F+E    L A ++QLE  + E  +++   SK+
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 226/1108 (20%), Positives = 419/1108 (37%), Gaps = 195/1108 (17%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ------------VQEWK 128
            K+ + L+ +   ++ K+  L  +  +   KL+E   H  QL+              QEW 
Sbjct: 297  KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 356

Query: 129  SKMQEQQADLQRRL--KEARKEAKEALEAK----ERYMEEMADT---------ADAIEMA 173
             K  + + +L   L  K+  +E  E L+ K    E ++ ++ D           D +++ 
Sbjct: 357  EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416

Query: 174  TLDKEMA---------EERAESL-----QQEVEALKER---------VDELTTDLEI--- 207
            TL +E A         + R E L     QQE + L ER         +  L TDL+    
Sbjct: 417  TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476

Query: 208  ----LKAEIEEKG-SDGAASSYQLKQLEEQ----NARLKDALVRMRDLSSSEKQEHVKLQ 258
                 K E+E+   + GA  + Q+  L  +    NA ++     +  L    K++  +L 
Sbjct: 477  NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536

Query: 259  KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA---------ALGAEEMVEML 309
            + ++++ Q  + +R Q E+L   L Q E  + E+ E+ +A         A  AEE    L
Sbjct: 537  QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596

Query: 310  TDRNLNL-------EEKVRELRETVGDLEAMNEMNDELQEN---ARETELELREQLDMAG 359
             +R+  L       +EK  +L      L+  NE  D  Q +   A+  + EL  +++   
Sbjct: 597  RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656

Query: 360  ARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE-------------A 406
            A V  A++    AQ  VA+ +  ++  +Q     + V +E    QE              
Sbjct: 657  ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716

Query: 407  SVERQQQPPPETFDFKIKF-----AETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 461
            S+E +++   +  + + +      AET++  +  + E +++E  +A R        +   
Sbjct: 717  SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR------KGLEAR 770

Query: 462  FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE--LSENCSERPGLRGAAGEQLSFA 519
              + G  H     +L   R + +A   +  A+ + E  + E  + R     +  E+  + 
Sbjct: 771  LQQLGEAHQAETEVL--RRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828

Query: 520  AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDE 579
            A     L  L+    +    L +      +KV  +     +H        EL    Q +E
Sbjct: 829  AMFQEQLMTLKEECEKARQELQEAK----EKVAGI----ESHS-------ELQISRQQNE 873

Query: 580  TVNVEP-LTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQ 638
               +   L +A++  Q         + E    +LAD +   Q  +   S EV RL   ++
Sbjct: 874  LAELHANLARALQQVQ---------EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924

Query: 639  --GGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDC 696
              G Q+ T    L+++   +     ++ ++ + R   +    + A      Q+ + L   
Sbjct: 925  KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984

Query: 697  RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA--ALEELAFKASEQIYGTPSSSPYEC 754
            R  L       QE      + +A L +  G   A  ALE+ A    E             
Sbjct: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-------RLQNA 1037

Query: 755  LRQSCNILISTMNKLATAMQEGE-YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLED 813
            L +      +    LA A+ E E  D E    +     L AA ++           +LE+
Sbjct: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLR----GLEAAQIK-----------ELEE 1082

Query: 814  RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRK 873
                +K+LK+ L  K +E +  +            A  +A  R E    +LE  +A + K
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGS-----------GAQSEAAGRTEPTGPKLEALRAEVSK 1131

Query: 874  KEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEE 933
             E++ ++  +   +    LEAE+A   +R    +  T++G        +    S +A  +
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSALASAQ 1189

Query: 934  QQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLP 993
            ++  A   +           K       Q++  R    + + +NS++   + + S+    
Sbjct: 1190 RELAAFRTKVQDHSKAEDEWK------AQVARGR---QEAERKNSLISSLEEEVSI---- 1236

Query: 994  PLHVAKLSHEGPGSELP--AGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQL 1051
             L+   L  EG   EL     A   K+ +L E L  L   T        S  A   S+ L
Sbjct: 1237 -LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAET-----ASNSARAAERSSAL 1290

Query: 1052 MEQVAQLKSLSDTVEKLKDEVLKETVSQ 1079
             E+V  L+  ++      + + +E  SQ
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQ 1318



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 209/1042 (20%), Positives = 418/1042 (40%), Gaps = 120/1042 (11%)

Query: 89   QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQL--------EQVQEWKSKMQEQQADLQR 140
            ++ +L +K E+L ++  E   + ++L+  K Q+        E+  +   K++E  + LQ+
Sbjct: 277  ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
                  +  +E  +A + ++E+ A     +  A  DK+  EE+ E LQ ++  L+E + +
Sbjct: 337  LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
            L  +    K E+            QL+ L+++ A           L+++  Q   +++ L
Sbjct: 397  LQDNPPQEKGEV-------LGDVLQLETLKQEAA----------TLAANNTQLQARVEML 439

Query: 261  MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTD-RNLNLEEK 319
              ++ Q+   +  +R   +EE  Q  S I +L+  +     A+E +E  +      L  +
Sbjct: 440  ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 320  VRELRETVGDLEAMNEMNDE----LQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            V  L   +  L A  +  D+    L++ A+E + +L + L       +  + +VE    +
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +   +Q +K+     A  Q+  R+   QQ A+   +++      D  +K  E     KA 
Sbjct: 560  LKQKEQQLKE----VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615

Query: 436  EMELRQMEVAQANR-----HMSLLTAFMPDSFL-RPGGDHDCVLVLLLMPRLICKAELIR 489
            ++E+ Q ++  AN        S+  A    + L R   +    +      +   +A++  
Sbjct: 616  KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675

Query: 490  KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549
             + Q + E  +  +E+  +     +       L  SL + + +L   +      + D  +
Sbjct: 676  LELQLRSE-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR----AADALE 730

Query: 550  KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
            +      E+ A  RSL    +   K+  +E    + L   +   Q L   H AE  E   
Sbjct: 731  EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEAHQAE-TEVLR 786

Query: 610  MQLADHI---KFTQSALDCMSVEVGRLRAFLQGGQ--EATDIALL---LRDLETSCSDIR 661
             +LA+ +      +S  + +  EV   R   +  Q  EA   A+    L  L+  C   R
Sbjct: 787  RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846

Query: 662  QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 721
            Q  ++ + ++ G ++    + L    Q ++ L +   +L   +  +QE    A +L   L
Sbjct: 847  QELQEAKEKVAGIES---HSELQISRQQNE-LAELHANLARALQQVQEKEVRAQKLADDL 902

Query: 722  AENEGLL------VAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE 775
            +  +  +      VA LE L  KA EQ      ++  E +++                ++
Sbjct: 903  STLQEKMAATSKEVARLETLVRKAGEQ----QETASRELVKEPAR----------AGDRQ 948

Query: 776  GEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEA 835
             E+  E+   +    +   AAL+A   +AE +G +LE     + E   S   + EE  + 
Sbjct: 949  PEWLEEQQGRQFCSTQ---AALQAMEREAEQMGNELERLRAALME---SQGQQQEERGQQ 1002

Query: 836  NVRLSLLEKKLDSAAKDADERIEK-VQTRLE-ETQALLRKKEKEFEETMDALQADIDQLE 893
               ++ L ++   A   AD  +EK  +  LE   Q  L ++  EF    +AL   + + E
Sbjct: 1003 EREVARLTQERGRA--QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060

Query: 894  AEKAELK--QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPG---QAPGSVP 948
             +  EL   + L +   + +E LR      +  L   +A +E++  +  G   +A G   
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELR----QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116

Query: 949  GPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSE 1008
              G          ++ A+R  +S+L  E    K  +   SL        A  +      E
Sbjct: 1117 PTG---------PKLEALRAEVSKL--EQQCQKQQEQADSLERSLEAERASRAERDSALE 1165

Query: 1009 LPAGALYRKTSQLLETLNQLST--------HTHVVDITRTSPAAKSPSAQLMEQVAQLKS 1060
               G L  K  +L  + + L++         T V D ++     K+  A+  ++  +  S
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225

Query: 1061 LSDTVEKLKDEVLKETVSQRPG 1082
            L  ++E+ +  +L   V ++ G
Sbjct: 1226 LISSLEE-EVSILNRQVLEKEG 1246



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 192/926 (20%), Positives = 358/926 (38%), Gaps = 159/926 (17%)

Query: 71   GAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
            G V  L +  +E   L A    L+ ++E L  +R + +AKL     H    E+ Q+  S 
Sbjct: 410  GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE--EEKQQLSSL 467

Query: 131  MQEQQADLQRRLKEARKEAKEALEAK-ERYMEEMADTADAIEMATLD------------- 176
            + + Q+ +   L +A++E ++A +A   R   ++A      E+ TL+             
Sbjct: 468  ITDLQSSISN-LSQAKEELEQASQAHGARLTAQVASLTS--ELTTLNATIQQQDQELAGL 524

Query: 177  KEMAEER----AESLQQEVEA---LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ- 228
            K+ A+E+    A++LQQ+ +A   L+ +V++L++ L+  + +++E      A+     Q 
Sbjct: 525  KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584

Query: 229  ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284
                 EE+ A L++    ++ L + EK++  KL+ L     Q+L+V  + R+  Q  ++Q
Sbjct: 585  LATAAEEREASLRERDAALKQLEALEKEKAAKLEIL----QQQLQVANEARDSAQTSVTQ 640

Query: 285  AESTIDELKEQVD--------AALGAEEMVEMLTDRNLNL---EEKVRELRETVGDLEAM 333
            A+    EL  +V+        A     E    + +  L L   ++K  E      + + +
Sbjct: 641  AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700

Query: 334  NEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL 393
             E    L+E+ + T+  L E+   A   + E Q+ +    E  A+ +  ++++++    L
Sbjct: 701  QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI---SELKAETRSLVEQHKRERKEL 757

Query: 394  QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANRHM 451
            ++        +    +  +    ET   + + AE  A     E E  Q+  EVA      
Sbjct: 758  EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER- 816

Query: 452  SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
                              +     +   +L+   E   K  QE  E  E  +   G+   
Sbjct: 817  -----------YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESH 862

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK---KVGSLYPEMSAHERSLDFL 568
            +  Q+S        L+ L A L R    + +  V   K    + +L  +M+A  + +  L
Sbjct: 863  SELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919

Query: 569  IELLHK-DQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDC-- 625
              L+ K  +  ET + E + +  +            QPE    Q       TQ+AL    
Sbjct: 920  ETLVRKAGEQQETASRELVKEPARAGD--------RQPEWLEEQQGRQFCSTQAALQAME 971

Query: 626  -----MSVEVGRLRAFL---------QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRM 671
                 M  E+ RLRA L         + GQ+  ++A L ++   + +D+           
Sbjct: 972  REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL----------- 1020

Query: 672  PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
                A    A      ++ + L + R     +   L             LA+  GL  A 
Sbjct: 1021 ----ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076

Query: 732  LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 791
            ++EL                 E LRQ+   L   + K       G         +  P  
Sbjct: 1077 IKEL-----------------EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119

Query: 792  LRAAALRAEIT-----------DAEGLGLKLE-------DRETVIKELKKSLKIKGEE-- 831
             +  ALRAE++            A+ L   LE       +R++ ++ L+  L+ K +E  
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG 1179

Query: 832  -----LSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE--KEFEETMDA 884
                 L+ A   L+    K+   +K  DE   +V    +E +   RK       EE +  
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE---RKNSLISSLEEEVSI 1236

Query: 885  LQADIDQLEAEKAELKQRLNSQSKRT 910
            L   + + E E  ELK+ + ++S+++
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKS 1262



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 189/876 (21%), Positives = 334/876 (38%), Gaps = 114/876 (13%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS----KMQEQQAD 137
            +E+ +RAQ   L + L TL+ K A    ++  LE    +  + QE  S    K   +  D
Sbjct: 889  QEKEVRAQ--KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946

Query: 138  LQRRLKEARK-----EAKEALEAKERYMEEMADTADAIEMATLDKE--MAEERAESLQQE 190
             Q    E ++       + AL+A ER  E+M +  + +  A ++ +    EER +  ++E
Sbjct: 947  RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ-ERE 1005

Query: 191  VEALKERVDELTTDLEILKA---EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
            V  L +       DL + KA   E+E +  +       L +   + A L++AL       
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNA------LNEQRVEFATLQEALAHALTEK 1059

Query: 248  SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE--- 304
              + QE  KL+ L   + +ELE +RQ  ++L+E+L++ E            A G  E   
Sbjct: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119

Query: 305  -MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARV 362
              +E L      LE++ ++ +E    LE   E  +      R++ LE L+ QL+     +
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEA-ERASRAERDSALETLQGQLEEKAQEL 1178

Query: 363  REAQKRVEAAQETVADYQQTIKKYR--------QLTAHLQDVNRE----LTNQQEASVER 410
              +Q  + +AQ  +A ++  ++ +         Q+    Q+  R+     + ++E S+  
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238

Query: 411  QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 470
            +Q    E    ++K        K+ ++E R + + QA    +   A    S LR      
Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEER-LRLLQAETASNSARAAERSSALRE----- 1292

Query: 471  CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQ 530
                         + + +R++A+++   SEN      LR     Q   A  L   L   Q
Sbjct: 1293 -------------EVQSLREEAEKQRVASEN------LRQELTSQAERAEELGQELKAWQ 1333

Query: 531  ATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAI 590
                + E ALS   ++              H  +   + ELL    L + +  E      
Sbjct: 1334 EKFFQKEQALSTLQLE--------------HTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379

Query: 591  KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
            ++ + L      EQ +     L   +   Q        E+G L    Q   E    A  L
Sbjct: 1380 RHREEL------EQSKQAAGGLRAELLRAQR-------ELGELIPLRQKVAEQERTAQQL 1426

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHL---------- 700
            R  + S ++     KK    +   +  G+      G Q  +  LD  +            
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLL-AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485

Query: 701  ---TWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQ 757
               T +  V +E  + A +L    A+ EG  V  LEE      E+   T      E  ++
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545

Query: 758  SCNILISTMNK-LATAMQEGEYDAER---PPSKPPPVELRAAALRAEITDAEGLGLKLED 813
                 +  ++K LA + Q  +   ++     ++    +  A  L+A++ + +    + E 
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605

Query: 814  RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE-RIEKVQTRLEETQALLR 872
                 K   +  K   +   + N  L    + L+   K+  E R E  +   E  QA L 
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL- 1664

Query: 873  KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
             K KE E+T   L A +  LEA+ A   Q+L    K
Sbjct: 1665 -KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 80/356 (22%), Positives = 151/356 (42%), Gaps = 55/356 (15%)

Query: 85   GLRAQV----RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            GLRA++    R+L E L  LR K AE +   ++L   K    +      K     A+  R
Sbjct: 1394 GLRAELLRAQRELGE-LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452

Query: 141  RLKEARKEAKEALE-----AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
             L E     ++ LE     A+E+Y++E+A            +  AE R   +Q+E ++  
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAV----------RADAETRLAEVQREAQSTA 1502

Query: 196  ERVDELTTDLEILKAEIEEKGS----DGAASSYQLKQLE----EQNARLKDALVRMRDLS 247
              ++ +T   E  K ++ E+      +    + Q++QLE    EQ  ++++   ++ D  
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562

Query: 248  SSEKQEHVKLQKLMEK---KNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
             + K +  KL+ +  +     QE + ++ Q   LQ +LSQ E   +  K Q++ A   + 
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA---KT 1619

Query: 305  MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
              +    +N  L+E++R L                  E  ++   ELR + +  G  +++
Sbjct: 1620 HYDAKKQQNQELQEQLRSL------------------EQLQKENKELRAEAERLGHELQQ 1661

Query: 365  AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPPPE 417
            A  + + A++T       ++      AH     R+L   Q   +A   R+ Q  P+
Sbjct: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 82/399 (20%), Positives = 178/399 (44%), Gaps = 37/399 (9%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI-QLEQVQEWKSKMQEQQADLQ 139
            +E E   + +  LEE++  L  +  E + + KEL++  + + E+ Q+ + +++  QA+  
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277

Query: 140  RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
                 A + +    E  +   EE      A E    +     ERAE L QE++A +E+  
Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF 1337

Query: 200  ELTTDLEILKAE-----------------IEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
            +    L  L+ E                  ++  ++ AA+  + ++  EQ+ +    L  
Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG- 301
                +  E  E + L++ + ++ +  + +R ++    E+LS  +     L E+ +  LG 
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGE 1456

Query: 302  ----AEEMVEMLTDRNLNLEEKVRELRETVGDLEA-MNEMNDELQENARETELELREQLD 356
                  + +E+  D+    E+ V+EL     D E  + E+  E Q  ARE E+   +   
Sbjct: 1457 RANLGRQFLEVELDQ--AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK--- 1511

Query: 357  MAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
              GA+V+   E Q+  E  Q+  A  +Q     R+ T  +++++++L +  +AS  +QQ+
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571

Query: 414  PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
                    + +  E++  A+ ++ +L +++   + +  +
Sbjct: 1572 LKA----VQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 73/328 (22%), Positives = 133/328 (40%), Gaps = 73/328 (22%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----------------------KIQLEQ 123
            LR +V + E   + LR ++A    +L  L+K                       +++L+Q
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471

Query: 124  VQE-WKSKMQEQQADLQRRLKEARKEAK------------------EALEAKERYMEEMA 164
             +E +  ++   +AD + RL E ++EA+                  + LE ++R+ EE  
Sbjct: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER- 1530

Query: 165  DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 224
                  +  T   E  E       ++VE L +++ +     ++ + +++   + G  S  
Sbjct: 1531 ------QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584

Query: 225  QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284
            + ++L+ Q   L+  L +       +  EH KLQ  MEK     +  +QQ + LQE+L  
Sbjct: 1585 EAQRLQAQLNELQAQLSQ-----KEQAAEHYKLQ--MEKAKTHYDAKKQQNQELQEQLRS 1637

Query: 285  AESTIDELKEQVDAA--LG------------AEEMVEMLTDRNLNLEEKVRELRETVGDL 330
             E    E KE    A  LG            AE+    LT +  +LE +V    + + DL
Sbjct: 1638 LEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697

Query: 331  EAMNEMNDELQENARETELELREQLDMA 358
                   D L    +  E + + QLD++
Sbjct: 1698 GKFQVATDAL----KSREPQAKPQLDLS 1721



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 197/982 (20%), Positives = 370/982 (37%), Gaps = 134/982 (13%)

Query: 171  EMATLDKEMAEERAESLQQEVEALKER--VDELTTDLEILKAEIE------EKGSDGAAS 222
            +M  L K++A+ER+   + E+E  + R  + E    + +++  I+      EK +     
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274

Query: 223  SYQLKQLEEQN----ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKN----------QEL 268
              +L++L ++N     RL + L + +DL + + Q   K+ +L E+              L
Sbjct: 275  PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334

Query: 269  EVVRQQRERLQEELSQAESTIDELKEQVDAALGA--------EEMVEMLTDRNLNLEEKV 320
            + ++     L EE S+A     E + Q++  L A        EE  E+L  +   LEE +
Sbjct: 335  QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394

Query: 321  RELRETVGDLEAMNEMNDELQ-ENARETELELREQLDMAGARVREAQ-KRVEAAQETVAD 378
             +L++     E    + D LQ E  ++    L        ARV   + +R +   + +A+
Sbjct: 395  SQLQDNPPQ-EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453

Query: 379  YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
                 ++ +QL++ + D+   ++N  +A  E +Q           + A   +    +   
Sbjct: 454  RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513

Query: 439  LRQMEVAQA-------NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            ++Q +   A        +   L            G  H    V  L   L  K + +++ 
Sbjct: 514  IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ---VEQLSSSLKQKEQQLKEV 570

Query: 492  AQEK--------FELSENCSERPGL---RGAAGEQL-SFAAGLVYSLSLLQATLHRYEHA 539
            A+++         +L+    ER      R AA +QL +        L +LQ  L     A
Sbjct: 571  AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630

Query: 540  LSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS- 598
                   V  +      E+S     L   +E   ++Q +    V  L   ++  Q   + 
Sbjct: 631  RDSAQTSV-TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689

Query: 599  ----IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLE 654
                    +Q ++    L + +K T+ +L+    E  R    L+  Q        + +L+
Sbjct: 690  KERVAQEKDQLQEQLQALKESLKVTKGSLE---EEKRRAADALEEQQRC------ISELK 740

Query: 655  TSCSDIRQFCKKIRRRMPGTDA--PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAA 712
                 + +  K+ R+ +    A   G+ A L    Q+ +       H      + +E+A 
Sbjct: 741  AETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEA------HQAETEVLRRELAE 791

Query: 713  AAAQLIAPLAENEGLL--VAALEELAFKASEQ---IYGTPSSSPYECLRQSC----NILI 763
            A A      +E E L+  VAA  E  ++ S+Q    YG         L++ C      L 
Sbjct: 792  AMAAQHTAESECEQLVKEVAAWRE-RYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850

Query: 764  STMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKK 823
                K+A      E    R  ++   +    A    ++ + E    KL D  + ++E   
Sbjct: 851  EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE--- 907

Query: 824  SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA--LLRKKEKEFEET 881
                K    S+   RL  L +K     + A   + K   R  + Q   L  ++ ++F  T
Sbjct: 908  ----KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963

Query: 882  MDALQA---DIDQLEAEKAELKQRL-NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 937
              ALQA   + +Q+  E   L+  L  SQ ++  E  RG     +A L        Q+RG
Sbjct: 964  QAALQAMEREAEQMGNELERLRAALMESQGQQQEE--RGQQEREVARLT-------QERG 1014

Query: 938  AIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQH--ENSILKGAQMKASLASLPPL 995
                QA  ++      +    L   ++  R+  + LQ    +++ +       LA L  L
Sbjct: 1015 R--AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072

Query: 996  HVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTS-PAAKSPSAQLMEQ 1054
              A++               ++  +L +T+ QL       +    S   A+S +A   E 
Sbjct: 1073 EAAQI---------------KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 1055 VA-QLKSLSDTVEKLKDEVLKE 1075
               +L++L   V KL+ +  K+
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQ 1139



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 197/985 (20%), Positives = 373/985 (37%), Gaps = 143/985 (14%)

Query: 216  GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 275
            GS  +     L+  + Q  RLK  L   R      + E  + +KL+ +K+ ++ +++Q+ 
Sbjct: 199  GSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258

Query: 276  ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA--- 332
            +RL        + ++E  +Q  + L  +E+ E L D+N +L  ++ E  +   DL+    
Sbjct: 259  DRL--------ALLNE--KQAASPLEPKEL-EELRDKNESLTMRLHETLKQCQDLKTEKS 307

Query: 333  --------MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 384
                    ++E N +L    RE    L++  D       E  K  +   E  A  ++ + 
Sbjct: 308  QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367

Query: 385  KYRQLTAHLQDVNR----ELTNQQEASVERQQQPPPETFD----------FKIKFAETKA 430
               Q    L++ N     +L+  +E   + Q  PP E  +           K + A   A
Sbjct: 368  AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427

Query: 431  HAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 490
            +   ++  +  +E  +  +   LL         R   + +   +  L+  L      I  
Sbjct: 428  NNTQLQARVEMLETERGQQEAKLLAE-------RGHFEEEKQQLSSLITDL---QSSISN 477

Query: 491  QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 550
             +Q K EL E  S+  G R  A       A L   L+ L AT+ + +  L+       +K
Sbjct: 478  LSQAKEEL-EQASQAHGARLTAQ-----VASLTSELTTLNATIQQQDQELAGLKQQAKEK 531

Query: 551  VGSLYPEMSAHERS---LDFLIELL------HKDQLDETVNVEPLTKAIKYYQHLYSIHL 601
               L   +   E++   L   +E L       + QL E    +  T+      H   +  
Sbjct: 532  QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR----QDHAQQLAT 587

Query: 602  AEQPEDCTMQLADHIKFTQSALDC-MSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
            A +  + +++  D       AL+   + ++  L+  LQ   EA D A      +TS +  
Sbjct: 588  AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA------QTSVTQA 641

Query: 661  RQFCKKIRRRMPGTDAPGIPA------ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAA 714
            ++   ++ R++    A    A      A A   ++   L   ++  T    V QE     
Sbjct: 642  QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701

Query: 715  AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQ 774
             QL A L E+  +   +LEE   +A++ +          C+ +   +   T + +    +
Sbjct: 702  EQLQA-LKESLKVTKGSLEEEKRRAADAL-----EEQQRCISE---LKAETRSLVEQHKR 752

Query: 775  E-GEYDAERPPSKPPPVELR---------AAALRAEITDAEGLGLKLEDR-ETVIKEL-- 821
            E  E + ER   K     L+            LR E+ +A       E   E ++KE+  
Sbjct: 753  ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812

Query: 822  -----KKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEK 876
                 + S + + +  +    +L  L+++ + A ++  E  EKV      ++  + +++ 
Sbjct: 813  WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQN 872

Query: 877  EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGI--AGEEQ 934
            E  E    L   + Q++ EK    Q+L +    T++         +A L + +  AGE+Q
Sbjct: 873  ELAELHANLARALQQVQ-EKEVRAQKL-ADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930

Query: 935  Q---RGAIPGQAPGSVPGPGLVKDSP-----LLLQQISAMRLHISQLQHENSILKGAQMK 986
            +   R  +   A      P  +++            + AM     Q+ +E   L+ A M+
Sbjct: 931  ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALME 990

Query: 987  A-----SLASLPPLHVAKLSHEGPGSE----LPAGALYRKTSQLLETLN----QLSTHTH 1033
            +              VA+L+ E   ++    L   A      +L   LN    + +T   
Sbjct: 991  SQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE 1050

Query: 1034 VVDITRTSPAAKSPSAQLME-----QVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTD 1088
             +    T    K      +      Q+ +L+ L  TV++LK+++ K+      G+   ++
Sbjct: 1051 ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110

Query: 1089 FA-----TFPSSAFLRA---KEEQQ 1105
             A     T P    LRA   K EQQ
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQ 1135


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)

Query: 81   KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
            KE E   +Q+ +    L+E+L+      AE +     L   K +LE++  E +++++E++
Sbjct: 876  KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
               Q+   E +K A++ L+ +E+  EE A    A +   L+K  AE + + L+ E+  + 
Sbjct: 936  DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 196  ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
            ++ ++L+ + ++L+  I +  ++ A    + K L +   + +  +  +      E++   
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051

Query: 256  KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +L+KL  K   +     +Q   LQ ++++ +  + + +E++ AAL    + + +  +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
              +K+REL   + DL+   +     +  A + + +L E+L+         +  +E   ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
             A  Q+   K  Q    L+    E T   EA V+  +Q                 HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205

Query: 436  E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
            E    +L Q + A+AN   +  T    ++ L          +   +H    +   +  L 
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 483  CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
             K    E  R +  +K    +N  E     L  A G+ +  A  +    S LQ T    +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325

Query: 538  HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
                Q  ++V  K+  L  E ++ +  LD   E+  K  L+    T+N++      K   
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 595  HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
               ++   E+ +    +    L    +   +A D +     RL+      QE  D+ +  
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
             DL+     +    KK R+                     D LL   K+++   A  ++ 
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473

Query: 711  AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
            A A A+      E + L +A   E A +A E++  T      E                 
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
            L +S   L + M ++ T ++E E + +        +E+   AL+ +      L  + E  
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587

Query: 815  ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
            E   ++L++ L     EL +   + +L    +KKL+   KD + + +      EE    L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647

Query: 872  RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
            RK +   K+F+  ++  +A  D++ A   E     N +  +++E         +A     
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 929  IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
                + ++  +  +   S+ G   ++D    L+ +I+ +   + + Q     +     KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 988  SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
            +          +LS+E       A        QL     +L +  H ++         T 
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
             A ++  AQL EQV   A+ K  +    K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)

Query: 96   KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
            KL   +  R   K K L ++ + + +++  ++   K +E+Q   +  LKE  ++  +  E
Sbjct: 828  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887

Query: 155  AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
             K    E++            + E+  E AE ++  + A K+ ++E+  ++E   A +EE
Sbjct: 888  EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933

Query: 215  KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
            +   G     + K++ +Q   L++ L          + E V  +  ++K   E+ V+  Q
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993

Query: 275  RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
              +L +E    E  I +    L E+ + A          E M+  L  R L  EEK R+ 
Sbjct: 994  NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052

Query: 323  ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
                 R+  GD    +E   +LQ    E +++L +       +  E Q  +    + +A 
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105

Query: 379  YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
                +KK R+L  H+ D+  +L +++ A    E+Q++   E  +      E    + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165

Query: 437  MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
             ELR    A+  + +++L   + +        H+  +            E+ +K AQ   
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206

Query: 497  ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
            EL+E   +    +    +         A L   L +L       EH   +    V +   
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263

Query: 553  SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
             L  + S  ER+   L + +HK Q +E  +V     E   KAIK  + + S+    Q   
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 608  CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
              +Q     K   S  L  +  E   L+  L    EA               +D    L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381

Query: 652  DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
            D  ++   + +  K+ ++ +          A A+     D L   +  L       QE+ 
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430

Query: 712  AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
                 L     +N+  LV+ LE+   K  + +    + SS Y   R             A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
             ++     +A     +   +E     L+AE+ D   L    +D    + EL+KS +    
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539

Query: 831  ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
            ++ E   +L  LE +L  A +DA  R+E  +Q    + +  L+ ++++ EE    LQ  +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598

Query: 890  DQLEAE-KAELKQR-LNSQSKRTIEG 913
             + E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
            +K+EE L+A +  L++++     ++     K++ELE H    +  L+  +  ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
             DL   L+  + E ++ L++     E  A     +   T+ K+  +E   S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198

Query: 196  ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
            ++    V+ELT  LE  K            +E++ +D A     L Q    +E +  +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258

Query: 238  DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
              +  ++   S  ++   +L   + K   E+E V       + +  +    +  L  Q+ 
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 298  AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
                 +E+++  T + LN+  K+R+L E    L+   +   E ++N       L  QL  
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
            +  ++++    VEA +E    +Q+ I+   Q                  L   L D+  +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 400  LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
            L NQ++  +++E++Q    Q   E  +   K+A+   +A A+A E E + + +A+A    
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491

Query: 452  SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
                                     L   L  K EL R     K E+ +  S +  +   
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
              E       L   +  ++  L   E  L Q + D       L  E++       F  +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580

Query: 572  LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
              +D+ +E        + ++   H Y   L ++ +   +  A   K      D       
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 632  RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
             ++   +  ++   +   ++D +    D R    +I       +  A  + A L    + 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 690  SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
                   RK        L E  A++      L + +  L A + +L  +  E+     + 
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755

Query: 750  SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
            S  + +R++        N+LAT        A++  S    +E +   LR+++ + EG  +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808

Query: 810  KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
            K + + T+      +L+ K  +L E   + +  ++    + K  D++++++  ++E+   
Sbjct: 1809 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1861

Query: 870  LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 909
              RK  ++++E  +   A + QL+    E  E  QR+N+  ++
Sbjct: 1862 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            L   ++DLE + ++    R E    +K+L K + Q++  Q      +  + ++    KE 
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
             K+AK       +  E++A    A + A L+K E+AEE A SL     AL++    L   
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737

Query: 205  LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
            +  L+ E+EE+  +  A S ++++  +Q  +L + L   R  S+++K E  + Q  +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793

Query: 265  NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
            N+EL     E+    + + +  ++  E+ I +L+EQV+     ++          +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847

Query: 320  VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
             ++L+E +  +E   +M +           + +EQ +   ARV++ ++++E A+E     
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1891

Query: 380  QQTIKKYRQLTAHLQDVNRELTNQQEAS 407
                 + +++ A+ + + REL    E++
Sbjct: 1892 -----ESQRINANRRKLQRELDEATESN 1914



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
            V  L S   + E  RA++ D   KL+      T  L  AE KA KL K++     QL+  
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
            QE   +   Q+ ++  +L++  +E     +  +  ME   +    I    +    ++++ 
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 185  ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
            +     VEAL+E       ++E L  + EEK +          +L+++   L   L   R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440

Query: 245  DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
             L S+ +++  K  +L+ ++         +R+R + E  + E+    L   ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500

Query: 305  MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
             +E  T++ L  E            + V EL ++   LE  M EM  +L+E   E EL+ 
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557

Query: 352  REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
             E   +    V     + +  ++  A  +Q  +K RQL   L +   EL +      ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610

Query: 412  QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
            Q+            A   A  K +E +L+ +E+               DS ++  G  + 
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643

Query: 472  VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
            +             +L + QAQ K    EL +  + R  +   A E    A  L   L  
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691

Query: 529  LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
            LQ  L   E A  Q  ++  +    L   +S        +R L+  I  L ++  +E  N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 583  VEPLTKAIK 591
            +E ++  ++
Sbjct: 1752 MEAMSDRVR 1760



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)

Query: 67   LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 122
            L +  A+       K+   L+AQ++D + +LE  R  R E  A  KE EK    LE    
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 123  QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 162
            Q+QE    ++   +QADL++             + A ++ K  LEA+   +EE       
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750

Query: 163  -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 193
             M   +D +  AT     L  E+A ER+     ES +Q++E                   
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810

Query: 194  -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
              K  +  L   +  L+ ++E++  +  A++  LKQ   ++ +LK+ L+++ D    E++
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1863

Query: 253  EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
               + ++  EK N  ++ +++Q E  +EE  +  +   +L+ ++D A  + E +     R
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1919

Query: 313  NLN-LEEKVRELRET 326
             +N L+ K+R   ET
Sbjct: 1920 EVNALKSKLRRGNET 1934


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)

Query: 81   KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
            KE E   +Q+ +    L+E+L+      AE +     L   K +LE++  E +++++E++
Sbjct: 883  KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
               Q+   E +K A++ L+ +E+  EE A    A +   L+K  AE + + L+ E+  + 
Sbjct: 943  DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 196  ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
            ++ ++L+ + ++L+  I +  ++ A    + K L +   + +  +  +      E++   
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058

Query: 256  KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +L+KL  K   +     +Q   LQ ++++ +  + + +E++ AAL    + + +  +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
              +K+REL   + DL+   +     +  A + + +L E+L+         +  +E   ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
             A  Q+   K  Q    L+    E T   EA V+  +Q                 HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212

Query: 436  E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
            E    +L Q + A+AN   +  T    ++ L          +   +H    +   +  L 
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 483  CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
             K    E  R +  +K    +N  E     L  A G+ +  A  +    S LQ T    +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332

Query: 538  HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
                Q  ++V  K+  L  E ++ +  LD   E+  K  L+    T+N++      K   
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 595  HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
               ++   E+ +    +    L    +   +A D +     RL+      QE  D+ +  
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
             DL+     +    KK R+                     D LL   K+++   A  ++ 
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480

Query: 711  AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
            A A A+      E + L +A   E A +A E++  T      E                 
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
            L +S   L + M ++ T ++E E + +        +E+   AL+ +      L  + E  
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594

Query: 815  ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
            E   ++L++ L     EL +   + +L    +KKL+   KD + + +      EE    L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654

Query: 872  RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
            RK +   K+F+  ++  +A  D++ A   E     N +  +++E         +A     
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 929  IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
                + ++  +  +   S+ G   ++D    L+ +I+ +   + + Q     +     KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 988  SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
            +          +LS+E       A        QL     +L +  H ++         T 
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
             A ++  AQL EQV   A+ K  +    K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)

Query: 96   KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
            KL   +  R   K K L ++ + + +++  ++   K +E+Q   +  LKE  ++  +  E
Sbjct: 835  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894

Query: 155  AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
             K    E++            + E+  E AE ++  + A K+ ++E+  ++E   A +EE
Sbjct: 895  EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940

Query: 215  KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
            +   G     + K++ +Q   L++ L          + E V  +  ++K   E+ V+  Q
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000

Query: 275  RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
              +L +E    E  I +    L E+ + A          E M+  L  R L  EEK R+ 
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059

Query: 323  ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
                 R+  GD    +E   +LQ    E +++L +       +  E Q  +    + +A 
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112

Query: 379  YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
                +KK R+L  H+ D+  +L +++ A    E+Q++   E  +      E    + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 437  MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
             ELR    A+  + +++L   + +        H+  +            E+ +K AQ   
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213

Query: 497  ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
            EL+E   +    +    +         A L   L +L       EH   +    V +   
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270

Query: 553  SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
             L  + S  ER+   L + +HK Q +E  +V     E   KAIK  + + S+    Q   
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 608  CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
              +Q     K   S  L  +  E   L+  L    EA               +D    L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388

Query: 652  DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
            D  ++   + +  K+ ++ +          A A+     D L   +  L       QE+ 
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437

Query: 712  AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
                 L     +N+  LV+ LE+   K  + +    + SS Y   R             A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
             ++     +A     +   +E     L+AE+ D   L    +D    + EL+KS +    
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546

Query: 831  ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
            ++ E   +L  LE +L  A +DA  R+E  +Q    + +  L+ ++++ EE    LQ  +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605

Query: 890  DQLEAE-KAELKQR-LNSQSKRTIEG 913
             + E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
            +K+EE L+A +  L++++     ++     K++ELE H    +  L+  +  ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
             DL   L+  + E ++ L++     E  A     +   T+ K+  +E   S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205

Query: 196  ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
            ++    V+ELT  LE  K            +E++ +D A     L Q    +E +  +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265

Query: 238  DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
              +  ++   S  ++   +L   + K   E+E V       + +  +    +  L  Q+ 
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 298  AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
                 +E+++  T + LN+  K+R+L E    L+   +   E ++N       L  QL  
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
            +  ++++    VEA +E    +Q+ I+   Q                  L   L D+  +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 400  LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
            L NQ++  +++E++Q    Q   E  +   K+A+   +A A+A E E + + +A+A    
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498

Query: 452  SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
                                     L   L  K EL R     K E+ +  S +  +   
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
              E       L   +  ++  L   E  L Q + D       L  E++       F  +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587

Query: 572  LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
              +D+ +E        + ++   H Y   L ++ +   +  A   K      D       
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 632  RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
             ++   +  ++   +   ++D +    D R    +I       +  A  + A L    + 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 690  SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
                   RK        L E  A++      L + +  L A + +L  +  E+     + 
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762

Query: 750  SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
            S  + +R++        N+LAT        A++  S    +E +   LR+++ + EG  +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815

Query: 810  KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
            K + + T+      +L+ K  +L E   + +  ++    + K  D++++++  ++E+   
Sbjct: 1816 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1868

Query: 870  LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 909
              RK  ++++E  +   A + QL+    E  E  QR+N+  ++
Sbjct: 1869 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            L   ++DLE + ++    R E    +K+L K + Q++  Q      +  + ++    KE 
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
             K+AK       +  E++A    A + A L+K E+AEE A SL     AL++    L   
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744

Query: 205  LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
            +  L+ E+EE+  +  A S ++++  +Q  +L + L   R  S+++K E  + Q  +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800

Query: 265  NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
            N+EL     E+    + + +  ++  E+ I +L+EQV+     ++          +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854

Query: 320  VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
             ++L+E +  +E   +M +           + +EQ +   ARV++ ++++E A+E     
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1898

Query: 380  QQTIKKYRQLTAHLQDVNRELTNQQEAS 407
                 + +++ A+ + + REL    E++
Sbjct: 1899 -----ESQRINANRRKLQRELDEATESN 1921



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
            V  L S   + E  RA++ D   KL+      T  L  AE KA KL K++     QL+  
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
            QE   +   Q+ ++  +L++  +E     +  +  ME   +    I    +    ++++ 
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 185  ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
            +     VEAL+E       ++E L  + EEK +          +L+++   L   L   R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447

Query: 245  DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
             L S+ +++  K  +L+ ++         +R+R + E  + E+    L   ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507

Query: 305  MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
             +E  T++ L  E            + V EL ++   LE  M EM  +L+E   E EL+ 
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564

Query: 352  REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
             E   +    V     + +  ++  A  +Q  +K RQL   L +   EL +      ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617

Query: 412  QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
            Q+            A   A  K +E +L+ +E+               DS ++  G  + 
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650

Query: 472  VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
            +             +L + QAQ K    EL +  + R  +   A E    A  L   L  
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698

Query: 529  LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
            LQ  L   E A  Q  ++  +    L   +S        +R L+  I  L ++  +E  N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 583  VEPLTKAIK 591
            +E ++  ++
Sbjct: 1759 MEAMSDRVR 1767



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)

Query: 67   LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 122
            L +  A+       K+   L+AQ++D + +LE  R  R E  A  KE EK    LE    
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 123  QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 162
            Q+QE    ++   +QADL++             + A ++ K  LEA+   +EE       
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757

Query: 163  -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 193
             M   +D +  AT     L  E+A ER+     ES +Q++E                   
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817

Query: 194  -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
              K  +  L   +  L+ ++E++  +  A++  LKQ   ++ +LK+ L+++ D    E++
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1870

Query: 253  EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
               + ++  EK N  ++ +++Q E  +EE  +  +   +L+ ++D A  + E +     R
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1926

Query: 313  NLN-LEEKVRELRET 326
             +N L+ K+R   ET
Sbjct: 1927 EVNALKSKLRRGNET 1941


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)

Query: 81   KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
            KE E   +Q+ +    L+E+L+      AE +     L   K +LE++  E +++++E++
Sbjct: 883  KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
               Q+   E +K A++ L+ +E+  EE A    A +   L+K  AE + + L+ E+  + 
Sbjct: 943  DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 196  ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
            ++ ++L+ + ++L+  I +  ++ A    + K L +   + +  +  +      E++   
Sbjct: 999  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058

Query: 256  KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +L+KL  K   +     +Q   LQ ++++ +  + + +E++ AAL    + + +  +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
              +K+REL   + DL+   +     +  A + + +L E+L+         +  +E   ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
             A  Q+   K  Q    L+    E T   EA V+  +Q                 HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212

Query: 436  E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
            E    +L Q + A+AN   +  T    ++ L          +   +H    +   +  L 
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

Query: 483  CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
             K    E  R +  +K    +N  E     L  A G+ +  A  +    S LQ T    +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332

Query: 538  HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
                Q  ++V  K+  L  E ++ +  LD   E+  K  L+    T+N++      K   
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389

Query: 595  HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
               ++   E+ +    +    L    +   +A D +     RL+      QE  D+ +  
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
             DL+     +    KK R+                     D LL   K+++   A  ++ 
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480

Query: 711  AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
            A A A+      E + L +A   E A +A E++  T      E                 
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
            L +S   L + M ++ T ++E E + +        +E+   AL+ +      L  + E  
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594

Query: 815  ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
            E   ++L++ L     EL +   + +L    +KKL+   KD + + +      EE    L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654

Query: 872  RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
            RK +   K+F+  ++  +A  D++ A   E     N +  +++E         +A     
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 929  IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
                + ++  +  +   S+ G   ++D    L+ +I+ +   + + Q     +     KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769

Query: 988  SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
            +          +LS+E       A        QL     +L +  H ++         T 
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
             A ++  AQL EQV   A+ K  +    K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
            +K+EE L+A +  L++++     ++     K++ELE H    +  L+  +  ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
             DL   L+  + E ++ L++     E  A     +   T+ K+  +E   S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205

Query: 196  ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
            ++    V+ELT  LE  K            +E++ +D A     L Q    +E +  +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265

Query: 238  DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
              +  ++   S  ++   +L   + K   E+E V       + +  +    +  L  Q+ 
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 298  AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
                 +E+++  T + LN+  K+R+L E    L+   +   E ++N       L  QL  
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
            +  ++++    VEA +E    +Q+ I+   Q                  L   L D+  +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 400  LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
            L NQ++  +++E++Q    Q   E  +   K+A+   +A A+A E E + + +A+A    
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498

Query: 452  SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
                                     L   L  K EL R     K E+ +  S +  +   
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
              E       L   +  ++  L   E  L Q + D       L  E++       F  +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587

Query: 572  LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
              +D+ +E        + ++   H Y   L ++ +   +  A   K      D       
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 632  RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
             ++   +  ++   +   ++D +    D R    +I       +  A  + A L    + 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 690  SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
                   RK        L E  A++      L + +  L A + +L  +  E+     + 
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762

Query: 750  SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
            S  + +R++        N+LAT        A++  S    +E +   LR+++ + EG  +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815

Query: 810  KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 853
            K + + T+      I +L++ ++ +  E   A   L   +KKL             A+  
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875

Query: 854  DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 910
             E+ EK   R+++ +  L + E+E +        LQ ++D+       + + +N+   + 
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1934

Query: 911  IEGLRGPPP 919
               LRGPPP
Sbjct: 1935 ---LRGPPP 1940



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            L   ++DLE + ++    R E    +K+L K + Q++  Q      +  + ++    KE 
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
             K+AK       +  E++A    A + A L+K E+AEE A SL     AL++    L   
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744

Query: 205  LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
            +  L+ E+EE+  +  A S ++++  +Q  +L + L   R  S+++K E  + Q  +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800

Query: 265  NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
            N+EL     E+    + + +  ++  E+ I +L+EQV+     ++          +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854

Query: 320  VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
             ++L+E +  +E   +M +           + +EQ +   ARV++ ++++E A+E     
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903

Query: 380  QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
                +K ++      + N  +  +  A   + + PPP+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1941



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)

Query: 96   KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
            KL   +  R   K K L ++ + + +++  ++   K +E+Q   +  LKE  ++  +  E
Sbjct: 835  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894

Query: 155  AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
             K    E++            + E+  E AE ++  + A K+ ++E+  ++E   A +EE
Sbjct: 895  EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940

Query: 215  KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
            +   G     + K++ +Q   L++ L          + E V  +  ++K   E+ V+  Q
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000

Query: 275  RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
              +L +E    E  I +    L E+ + A          E M+  L  R L  EEK R+ 
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059

Query: 323  ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
                 R+  GD    +E   +LQ    E +++L +       +  E Q  +    + +A 
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112

Query: 379  YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
                +KK R+L  H+ D+  +L +++ A    E+Q++   E  +      E    + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172

Query: 437  MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
             ELR    A+  + +++L   + +        H+  +            E+ +K AQ   
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213

Query: 497  ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
            EL+E   +    +    +         A L   L +L       EH   +    V +   
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270

Query: 553  SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
             L  + S  ER+   L + +HK Q +E  +V     E   KAIK  + + S+    Q   
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 608  CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
              +Q     K   S  L  +  E   L+  L    EA               +D    L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388

Query: 652  DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
            D  ++   + +  K+ ++ +          A A+     D L   +  L       QE+ 
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437

Query: 712  AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
                 L     +N+  LV+ LE+   K  + +    + SS Y   R             A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
             ++     +A     +   +E     L+AE+ D   L    +D    + EL+KS +    
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546

Query: 831  ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
            ++ E   +L  LE +L  A +DA  R+E  +Q    + +  L+ ++++ EE    LQ  +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605

Query: 890  DQLEAE-KAELKQR-LNSQSKRTIEG 913
             + E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
            V  L S   + E  RA++ D   KL+      T  L  AE KA KL K++     QL+  
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
            QE   +   Q+ ++  +L++  +E     +  +  ME   +    I    +    ++++ 
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387

Query: 185  ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
            +     VEAL+E       ++E L  + EEK +          +L+++   L   L   R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447

Query: 245  DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
             L S+ +++  K  +L+ ++         +R+R + E  + E+    L   ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507

Query: 305  MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
             +E  T++ L  E            + V EL ++   LE  M EM  +L+E   E EL+ 
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564

Query: 352  REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
             E   +    V     + +  ++  A  +Q  +K RQL   L +   EL +      ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617

Query: 412  QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
            Q+            A   A  K +E +L+ +E+               DS ++  G  + 
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650

Query: 472  VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
            +             +L + QAQ K    EL +  + R  +   A E    A  L   L  
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698

Query: 529  LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
            LQ  L   E A  Q  ++  +    L   +S        +R L+  I  L ++  +E  N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 583  VEPLTKAIK 591
            +E ++  ++
Sbjct: 1759 MEAMSDRVR 1767



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)

Query: 72   AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 131
            A   L    K+ + +  QV D  +  E  + +  +  A++K+L++   QLE+ +E   ++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1903

Query: 132  QEQQADLQRRLKEARKEAKEAL 153
               +  LQR L EA  E+ EA+
Sbjct: 1904 NANRRKLQRELDEA-TESNEAM 1924


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)

Query: 81   KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
            KE E   +Q+ +    L+E+L+      AE +     L   K +LE++  E +++++E++
Sbjct: 876  KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
               Q+   E +K A++ L+ +E+  EE A    A +   L+K  AE + + L+ E+  + 
Sbjct: 936  DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 196  ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
            ++ ++L+ + ++L+  I +  ++ A    + K L +   + +  +  +      E++   
Sbjct: 992  DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051

Query: 256  KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +L+KL  K   +     +Q   LQ ++++ +  + + +E++ AAL    + + +  +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
              +K+REL   + DL+   +     +  A + + +L E+L+         +  +E   ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
             A  Q+   K  Q    L+    E T   EA V+  +Q                 HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205

Query: 436  E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
            E    +L Q + A+AN   +  T    ++ L          +   +H    +   +  L 
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265

Query: 483  CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
             K    E  R +  +K    +N  E     L  A G+ +  A  +    S LQ T    +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325

Query: 538  HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
                Q  ++V  K+  L  E ++ +  LD   E+  K  L+    T+N++      K   
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382

Query: 595  HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
               ++   E+ +    +    L    +   +A D +     RL+      QE  D+ +  
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
             DL+     +    KK R+                     D LL   K+++   A  ++ 
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473

Query: 711  AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
            A A A+      E + L +A   E A +A E++  T      E                 
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
            L +S   L + M ++ T ++E E + +        +E+   AL+ +      L  + E  
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587

Query: 815  ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
            E   ++L++ L     EL +   + +L    +KKL+   KD + + +      EE    L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647

Query: 872  RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
            RK +   K+F+  ++  +A  D++ A   E     N +  +++E         +A     
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 929  IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
                + ++  +  +   S+ G   ++D    L+ +I+ +   + + Q     +     KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762

Query: 988  SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
            +          +LS+E       A        QL     +L +  H ++         T 
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
             A ++  AQL EQV   A+ K  +    K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
            +K+EE L+A +  L++++     ++     K++ELE H    +  L+  +  ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
             DL   L+  + E ++ L++     E  A     +   T+ K+  +E   S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198

Query: 196  ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
            ++    V+ELT  LE  K            +E++ +D A     L Q    +E +  +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258

Query: 238  DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
              +  ++   S  ++   +L   + K   E+E V       + +  +    +  L  Q+ 
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 298  AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
                 +E+++  T + LN+  K+R+L E    L+   +   E ++N       L  QL  
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
            +  ++++    VEA +E    +Q+ I+   Q                  L   L D+  +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 400  LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
            L NQ++  +++E++Q    Q   E  +   K+A+   +A A+A E E + + +A+A    
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491

Query: 452  SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
                                     L   L  K EL R     K E+ +  S +  +   
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
              E       L   +  ++  L   E  L Q + D       L  E++       F  +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580

Query: 572  LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
              +D+ +E        + ++   H Y   L ++ +   +  A   K      D       
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 632  RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
             ++   +  ++   +   ++D +    D R    +I       +  A  + A L    + 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 690  SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
                   RK        L E  A++      L + +  L A + +L  +  E+     + 
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755

Query: 750  SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
            S  + +R++        N+LAT        A++  S    +E +   LR+++ + EG  +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808

Query: 810  KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 853
            K + + T+      I +L++ ++ +  E   A   L   +KKL             A+  
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868

Query: 854  DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 910
             E+ EK   R+++ +  L + E+E +        LQ ++D+       + + +N+   + 
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1927

Query: 911  IEGLRGPPP 919
               LRGPPP
Sbjct: 1928 ---LRGPPP 1933



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            L   ++DLE + ++    R E    +K+L K + Q++  Q      +  + ++    KE 
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
             K+AK       +  E++A    A + A L+K E+AEE A SL     AL++    L   
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737

Query: 205  LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
            +  L+ E+EE+  +  A S ++++  +Q  +L + L   R  S+++K E  + Q  +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793

Query: 265  NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
            N+EL     E+    + + +  ++  E+ I +L+EQV+     ++          +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847

Query: 320  VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
             ++L+E +  +E   +M +           + +EQ +   ARV++ ++++E A+E     
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896

Query: 380  QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
                +K ++      + N  +  +  A   + + PPP+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1934



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)

Query: 96   KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
            KL   +  R   K K L ++ + + +++  ++   K +E+Q   +  LKE  ++  +  E
Sbjct: 828  KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887

Query: 155  AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
             K    E++            + E+  E AE ++  + A K+ ++E+  ++E   A +EE
Sbjct: 888  EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933

Query: 215  KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
            +   G     + K++ +Q   L++ L          + E V  +  ++K   E+ V+  Q
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993

Query: 275  RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
              +L +E    E  I +    L E+ + A          E M+  L  R L  EEK R+ 
Sbjct: 994  NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052

Query: 323  ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
                 R+  GD    +E   +LQ    E +++L +       +  E Q  +    + +A 
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105

Query: 379  YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
                +KK R+L  H+ D+  +L +++ A    E+Q++   E  +      E    + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165

Query: 437  MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
             ELR    A+  + +++L   + +        H+  +            E+ +K AQ   
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206

Query: 497  ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
            EL+E   +    +    +         A L   L +L       EH   +    V +   
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263

Query: 553  SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
             L  + S  ER+   L + +HK Q +E  +V     E   KAIK  + + S+    Q   
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 608  CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
              +Q     K   S  L  +  E   L+  L    EA               +D    L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381

Query: 652  DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
            D  ++   + +  K+ ++ +          A A+     D L   +  L       QE+ 
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430

Query: 712  AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
                 L     +N+  LV+ LE+   K  + +    + SS Y   R             A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
             ++     +A     +   +E     L+AE+ D   L    +D    + EL+KS +    
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539

Query: 831  ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
            ++ E   +L  LE +L  A +DA  R+E  +Q    + +  L+ ++++ EE    LQ  +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598

Query: 890  DQLEAE-KAELKQR-LNSQSKRTIEG 913
             + E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
            V  L S   + E  RA++ D   KL+      T  L  AE KA KL K++     QL+  
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
            QE   +   Q+ ++  +L++  +E     +  +  ME   +    I    +    ++++ 
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380

Query: 185  ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
            +     VEAL+E       ++E L  + EEK +          +L+++   L   L   R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440

Query: 245  DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
             L S+ +++  K  +L+ ++         +R+R + E  + E+    L   ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500

Query: 305  MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
             +E  T++ L  E            + V EL ++   LE  M EM  +L+E   E EL+ 
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557

Query: 352  REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
             E   +    V     + +  ++  A  +Q  +K RQL   L +   EL +      ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610

Query: 412  QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
            Q+            A   A  K +E +L+ +E+               DS ++  G  + 
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643

Query: 472  VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
            +             +L + QAQ K    EL +  + R  +   A E    A  L   L  
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691

Query: 529  LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
            LQ  L   E A  Q  ++  +    L   +S        +R L+  I  L ++  +E  N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 583  VEPLTKAIK 591
            +E ++  ++
Sbjct: 1752 MEAMSDRVR 1760



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)

Query: 72   AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 131
            A   L    K+ + +  QV D  +  E  + +  +  A++K+L++   QLE+ +E   ++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1896

Query: 132  QEQQADLQRRLKEARKEAKEAL 153
               +  LQR L EA  E+ EA+
Sbjct: 1897 NANRRKLQRELDEA-TESNEAM 1917


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 176/853 (20%), Positives = 340/853 (39%), Gaps = 153/853 (17%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQA 136
            K+   L +Q+ +L+E LE+ R  R + + + +    ELE  K +LE   +  +  QE ++
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163

Query: 137  DLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALK 195
              ++ +   +K  +E  +  E  ++EM    + A+E      E  +    +L++  + L+
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223

Query: 196  ERVDELTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDAL--------VRMR 244
                EL  ++++L   K + E K     A   +L+    +  R++  L        V + 
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283

Query: 245  DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
            +++    Q   K  KL +  +     ++  +E LQEE  Q  S   +LK+  D      E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343

Query: 305  MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
             +E   +   NLE+++  L   V D++   E +    E A E + +L++ L+    R   
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR--- 1400

Query: 365  AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS--VERQQ----QPPPET 418
                    +E VA Y +  K   +L   L D+  +L +Q++++  +E++Q    Q   E 
Sbjct: 1401 -------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453

Query: 419  FDFKIKFAETK--AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL 476
                 K+AE +  A A+A E E + + +A+A                             
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARA----------------------------- 1484

Query: 477  LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRY 536
            L   +  KAEL R   Q + E+ +  S +  +  +  E                  L + 
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE------------------LEKS 1526

Query: 537  EHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHL 596
            + AL Q   ++  ++  L  E+ A E               D  + +E   +A+K     
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATE---------------DAKLRLEVNLQAMKAQFER 1571

Query: 597  YSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS 656
                  EQ E+   QL   ++  ++ L+    +  + R+     ++  ++ L  +DLE  
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELE----DERKQRSMAVAARKKLEMDL--KDLEAH 1625

Query: 657  CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQ 716
                 +   +  +++    A                + DC + L    A  +E+ A A +
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQ---------------MKDCMRELDDTRASREEILAQAKE 1670

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 776
                L   E  ++   EELA  A+E+          E   +  N    +  K A A++E 
Sbjct: 1671 NEKKLKSMEAEMIQLQEELA--AAERAKRQAQQERDELADEIAN----SSGKGALALEEK 1724

Query: 777  EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 836
                         +E R A L  E+ + +G    + DR                 L +AN
Sbjct: 1725 R-----------RLEARIAQLEEELEEEQGNTELINDR-----------------LKKAN 1756

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA-LQADIDQLEAE 895
            +++  +   L+     A ++ E  + +LE     L+ K +E E T+ +  +A I  LEA+
Sbjct: 1757 LQIDQINTDLNLERSHA-QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815

Query: 896  KAELKQRLNSQSK 908
             A+L+++L++++K
Sbjct: 1816 IAQLEEQLDNETK 1828



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 245/1120 (21%), Positives = 459/1120 (40%), Gaps = 158/1120 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQ 132
            V PL   S++EE + A+    EE+L  +R K+   + +L E+E  + QL        K+Q
Sbjct: 834  VKPLLQVSRQEEEMMAK----EEELVKVREKQLAAENRLTEMETLQSQL-----MAEKLQ 884

Query: 133  -EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191
             ++Q   +  L    +E +  L AK++ +EE+    +A        E  EER + LQ E 
Sbjct: 885  LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA------RVEEEEERCQHLQAEK 938

Query: 192  EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 241
            + +++ + EL   LE  ++  ++   +   +  +LK+LEE+   L+D             
Sbjct: 939  KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998

Query: 242  -RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
             R+ + +++  +E  K + L + KN+   ++    ERL+ E  Q +              
Sbjct: 999  DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE------------- 1045

Query: 301  GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
              E+    L   + +L +++ EL+  + +L+      +E  + A     E   Q +MA  
Sbjct: 1046 -LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104

Query: 361  RVREAQKRVEAAQETV----ADYQQTIKKYRQLTAHLQDVNRELTN-------QQEASVE 409
            ++RE + ++   QE +    A   +  K+ R L   L+ +  EL +       QQE   +
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164

Query: 410  RQQQPP--PETFDFKIKFAET------KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 461
            R+Q+     +T + + K  E       + H++A+E    Q+E  Q  R  + L       
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE--QTKRVKANLEKAKQTL 1222

Query: 462  FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAG 521
                G   + V VLL       K +   K+ + + +L E       L+    E       
Sbjct: 1223 ENERGELANEVKVLLQ-----GKGDSEHKRKKVEAQLQE-------LQVKFNEGERVRTE 1270

Query: 522  LVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETV 581
            L   ++ LQ  L      LSQ       K   L  + SA E  L    ELL ++   + +
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSD----SKSSKLTKDFSALESQLQDTQELLQEEN-RQKL 1325

Query: 582  NVEPLTKAIKYYQHLYSIHLAEQPE----------DCTMQLADHIKFTQSALDCMSV--E 629
            ++    K ++  ++ +   L E+ E              Q+AD  K  + ++ C+    E
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 630  VGR-LRAFLQGGQEATDIALLLRD-LETSCSDIRQFCKKIRRRMPGTDAPGIPAA-LAFG 686
            V R L+  L+G  +  +  +   D LE + + ++Q   ++   +   D     A  L   
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442

Query: 687  PQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGL-LVAALEE-LAFKASEQIY 744
             +  D LL   K ++   A  ++ A A A+      E + L L  ALEE +  KA  +  
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKAELERL 1498

Query: 745  GTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELRA---AALRA 799
                 +  E L  S + +  ++++L  + +  E   E   ++   +  EL+A   A LR 
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558

Query: 800  EIT----------DAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL---LEKKL 846
            E+           D +G   + E+++   K+L + ++    EL +   + S+     KKL
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKK---KQLVRQVREMEAELEDERKQRSMAVAARKKL 1615

Query: 847  DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETM---DALQADIDQLEAEKAELKQRL 903
            +   KD +  I+      +E    LRK + + ++ M   D  +A  +++ A+  E +++L
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675

Query: 904  NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQI 963
             S     I+         +A         +Q+R  +  +   S  G G      L L++ 
Sbjct: 1676 KSMEAEMIQ-----LQEELAAAERAKRQAQQERDELADEIANS-SGKG-----ALALEEK 1724

Query: 964  SAMRLHISQLQHE------NSILKGAQMKASLASLPPLHV---AKLSHEGPGSELPAGAL 1014
              +   I+QL+ E      N+ L   ++K +   +  ++     + SH    +E     L
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH-AQKNENARQQL 1783

Query: 1015 YRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQV--------AQLKSLSDTVE 1066
             R+  +L   L ++   T       +  A ++  AQL EQ+        A  K +  T +
Sbjct: 1784 ERQNKELKVKLQEME-GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842

Query: 1067 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQD 1106
            KLKD VL +   +R  A    D A   S+   + K + ++
Sbjct: 1843 KLKD-VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 96/365 (26%), Positives = 170/365 (46%), Gaps = 51/365 (13%)

Query: 64   TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE- 122
            T  L+   A+        E E L  Q R    ++E L   + +    + ELEK K  LE 
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQ 1532

Query: 123  QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
            QV+E K++++E + +LQ     A ++AK  LE   + M+   +     ++   D++  E+
Sbjct: 1533 QVEEMKTQLEELEDELQ-----ATEDAKLRLEVNLQAMKAQFER----DLQGRDEQSEEK 1583

Query: 183  RAESLQQEVEALKERVDE-------------LTTDLEILKAEIE--EKGSDGAASSYQLK 227
            + + ++Q  E   E  DE             L  DL+ L+A I+   K  D A     +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA-----IK 1638

Query: 228  QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 287
            QL +  A++KD +  + D  +S ++E +   K  EKK + +E    +  +LQEEL+ AE 
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRAS-REEILAQAKENEKKLKSMEA---EMIQLQEELAAAER 1694

Query: 288  TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 347
               + +++ D    A+E+        L LEEK R L   +  LE      +EL+E    T
Sbjct: 1695 AKRQAQQERDEL--ADEIANSSGKGALALEEK-RRLEARIAQLE------EELEEEQGNT 1745

Query: 348  ELELREQLDMAGARVREAQKRVEA----AQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 403
            EL + ++L  A  ++ +    +      AQ+     QQ  ++ ++L   LQ++   + ++
Sbjct: 1746 EL-INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804

Query: 404  QEASV 408
             +AS+
Sbjct: 1805 YKASI 1809



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 93/352 (26%), Positives = 171/352 (48%), Gaps = 47/352 (13%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKA-------KLKELEKH-----KIQLEQVQEWK 128
            ++++ L  QVR++E +LE  R +R+   A        LK+LE H     K + E +++ +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 129  SKMQEQQADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKEM-AEERAES 186
             K+Q Q  D  R L + R   +E L +AKE   E+   + +A EM  L +E+ A ERA+ 
Sbjct: 1642 -KLQAQMKDCMRELDDTRASREEILAQAKEN--EKKLKSMEA-EMIQLQEELAAAERAK- 1696

Query: 187  LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQ-------NARLKDA 239
             +Q  +   E  DE+          +EEK    A  +   ++LEE+       N RLK A
Sbjct: 1697 -RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755

Query: 240  LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
             +++  +++    E    QK  E   Q+LE   +Q + L+ +L + E T+    +    A
Sbjct: 1756 NLQIDQINTDLNLERSHAQK-NENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA 1811

Query: 300  LGAE--EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
            L A+  ++ E L +     +   +++R T   L+ +    D+ + NA     + ++Q D 
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE----QYKDQADK 1867

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD-------VNRELTN 402
            A  R+++ ++++E A+E   + Q+     R+L   L+D       +NRE+++
Sbjct: 1868 ASTRLKQLKRQLEEAEE---EAQRANASRRKLQRELEDATETADAMNREVSS 1916



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 65/299 (21%), Positives = 128/299 (42%), Gaps = 40/299 (13%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            K+   L+AQ++D   +L+  R  R E  A+ KE EK              M+ +   LQ 
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----------KSMEAEMIQLQE 1687

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA------- 193
             L  A +  ++A + ++   +E+A+++    +A  +K   E R   L++E+E        
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            + +R+ +    ++ +  ++  + S    +    +QLE QN  LK  L  M     S+ + 
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807

Query: 254  HV--------KLQKLMEKKNQELEV----VRQQRERLQEELSQAES---TIDELKEQVDA 298
             +        +L++ ++ + +E +     VR+  ++L++ L Q +      ++ K+Q D 
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867

Query: 299  ALGA--------EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 349
            A           EE  E     N +  +  REL +     +AMN     L+   R  +L
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 24/123 (19%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQ 135
            L + +KE +    QVR  E+KL          K  L +++  +   EQ ++   K   + 
Sbjct: 1823 LDNETKERQAACKQVRRTEKKL----------KDVLLQVDDERRNAEQYKDQADKASTRL 1872

Query: 136  ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
              L+R+L+EA +EA+ A  ++ +   E+ D              A E A+++ +EV +LK
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELED--------------ATETADAMNREVSSLK 1918

Query: 196  ERV 198
             ++
Sbjct: 1919 NKL 1921


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 130
            +KE++ L+      E   +TL   +AE+  K+  L K KI+LEQ          QE K +
Sbjct: 999  TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051

Query: 131  MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 185
            M  ++A  +R+L+   K A+E+   +E +++ ++E     +  E++ L  ++ +E+A   
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108

Query: 186  SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 227
             LQ++++ L+ R++EL  ++E     +A+ E++ SD               G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168

Query: 228  QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 280
              +++ A  +      RDL  +  Q       L +K         ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225

Query: 281  ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
            E S+ +  ID+L   V+    A    E+M   L D+   L+ K  E +  + DL A    
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282

Query: 337  NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 395
               LQ  + E   +L E+  +     R  Q   +  +E     ++ IK    L   LQ  
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342

Query: 396  ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
                  +  +   +QE+  E Q+   +   E   ++ K+ ET A  +  E+E  + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401

Query: 447  ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 502
                A  H+  + A                             E  +++ Q + E     
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437

Query: 503  SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 559
             ER     AA   +Q +F   L       + T     HA  + S    + +G+ L+   +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492

Query: 560  AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 615
            A+E SLD L E L ++  +    +  LT+ I    K    L  I    + E C +Q A  
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549

Query: 616  IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
                + A   +  E G+ LR  L+  Q  +++   + + +     +++   +I   M  T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 675  DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
                + A +                L  +   L      AA+ +      +G+L      
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662

Query: 735  L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 792
            L  A ++ E +           + +  N+L + + +L   +++ E   +    +      
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717

Query: 793  RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 844
            R   L  + T       KLE        + E +++E + + +   + +++A +    L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777

Query: 845  KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 898
            + D++A      K+ ++ ++ +Q RL+E + L  K  K+           I +LEA   E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827

Query: 899  LKQRLNSQSKRTIEGLRG 916
            L+  + S+ KR  E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            K+ + L+A++ +LEE++E  R  RA+ + +  +L +   +LE++ E   +++E       
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
            +++  +K  +EA   K R   E A        ATL K+ A+  AE L ++++ L+    +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
            L  +   +K EI++  S+    S     LE+    L+D L    +L S E+++   +  L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279

Query: 261  ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 310
                  ++ ++ E      ++E L  +LS+ +      I+ELK Q++  + A+  +    
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339

Query: 311  DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 358
              + +    L E+  E +E+  +L+ A+++ N E+ +       +A +   EL E     
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 359  GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 418
              R++ A++ VEA     A  ++T ++ +     L  ++ E TN   A+++++Q+   + 
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458

Query: 419  F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 471
              ++K K  ET A  +A + E R +     ++  A    +  L     ++        D 
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518

Query: 472  VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 529
               +    + I + E I+KQ  QEK EL     E    L    G+ L     L    S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578

Query: 530  QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 583
               +   +  + Q   +  + V S+   + A  RS +  I L  K     ++++  +N  
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638

Query: 584  -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 633
                 +A++ Y++   I      HL +     ED   QLA      +   + +  E+  L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694

Query: 634  RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 693
            RA L+  + +  IA      E    D  +  + +  +                   + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729

Query: 694  LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 753
            ++ +K L   ++ +Q        ++      E     A+ + A  A E      +S+  E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786

Query: 754  CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 810
             ++++      T+  L   + E E  A +   K    +E R   L  E+   +    +  
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843

Query: 811  --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
              L   E  +KE    L  + EE  +  +RL  L  KL +  K    + E+ + +     
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899

Query: 869  ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
            A  RK + E EE  +  +ADI + +  K  +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
            L    KE+     +V++L E++    ET+     E KA        L +L+  + ++  +
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 179
             + K K+++Q  DL+  L++ +K   +   AK +   ++    ++I     E   LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 180  AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 226
             ++  E  +LQ ++E        L++++ EL   +E L+ EIE + +  A +  Q     
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 227  KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 264
            ++LEE + RL++A       + M            RDL  +  Q       L +K     
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 265  ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 317
                ++++ +++ +++L++E S+ +  ID+L   V+    A    E+M   L D+   L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 318  EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
             K  E +  + DL A       LQ  + E   +L E+  +     R  Q   +  +E   
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323

Query: 378  DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 427
              ++ IK    L   LQ        +  +   +QE+  E Q+   +   E   ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382

Query: 428  TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 480
            T A  +  E+E  + ++AQ    A  H+  + A    +  +  R   + + +++ +    
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442

Query: 481  LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 531
              C A   +++  +K   E  + C E    L  +  E  S    L      Y  SL Q  
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502

Query: 532  TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 581
            TL R    L Q   D+ +++            +  ++   +  L   +E        E  
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562

Query: 582  NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 635
             +  +   +   +      +AE+ E+      +HI+  +S    +  E+       RL+ 
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 694
             ++G          L ++E   +   +   +  R    T   GI         + D L  
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669

Query: 695  --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 752
              D ++ L  V      + A   +L A L + E     A +EL   ASE++         
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            + L      LI+T  KL T + + + + E    +    E +A   +  ITDA  +  +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776

Query: 813  DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 861
              +     L++  K   + + +  +RL   E+           KL++  ++ +  +E  Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836

Query: 862  TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 910
             R  E    LRK E+  +E     + D          +D+L+A+    K++     +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)

Query: 102  LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 161
            LK AE +   KE+   K + +++++  +K + ++ +L+ ++    KE  +     +   E
Sbjct: 846  LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902

Query: 162  EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 207
             +AD  +         I++    KE+ E  E  E +  E+ A K +++    EL  D++ 
Sbjct: 903  GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962

Query: 208  LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 267
            L+  + +   +  A+  ++K L E+ A L + + ++    + EK      + L E   Q 
Sbjct: 963  LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012

Query: 268  LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 326
            L+ ++ + +++   L++A+  +++  + ++ +L  E+ + M  +R    LE  ++  +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 327  VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 383
            + D+E  NE   +L E  ++ E E   L+ +++   A   + QK+++  Q  + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 384  KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
            +  R   A  +    +L+ + E   ER ++    T     +    K      +   R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185

Query: 444  VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 501
             A  Q     + L     DS    G   D +  +        K +L +++++ K E+ + 
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237

Query: 502  CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 561
             S    +  A G        L   LS L++     +  ++    D+  + G L  E    
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293

Query: 562  ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 621
             R LD           ++   V  L++  + +         +Q E+   QL + IK   +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334

Query: 622  ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 678
               AL     +   LR   +  QE+   A L R L  + +++ Q+  K       TDA  
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385

Query: 679  IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 738
                     Q ++ L + +K L   +   +E   A     A L + +  L   +E+L   
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437

Query: 739  ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 798
                          E    +C  L          + E +   E   ++    +  A +L 
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 799  AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 858
             E+   +    +  D+   +K   K+L+ +  +L+E          +L+   K  ++   
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 859  KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
            ++Q  LEE +A L  +E +    +  ++ +++++D+  AEK E   +L     R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 916  GPPPSGIATLVSGIAGEEQQRG 937
                + I +    I  +++  G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)

Query: 88   AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
            A+ ++LEEK+ TL  ++              A+ + +  +L K KIQLE   +  ++  E
Sbjct: 874  AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933

Query: 134  QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
             + ++   L   +++ ++     ++ ++++  T   +E    +K   E + ++L +E+  
Sbjct: 934  DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            L E + +LT + + L+   ++   D  A   ++  L +   +L+  +  +      EK+ 
Sbjct: 991  LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050

Query: 254  HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 304
             + L++   K   +L++       +  ++++L E+L + E  I  L+ ++  + ALG   
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107

Query: 305  MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
                     + L++K++EL+  + +LE   E     +  A +   +L  +L+    R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 365  A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
            A      ++E  ++  A++Q+  +   + T   +     L  +   SV    +       
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 421  FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 475
             K K  + K+  K   ME+  +      V++A  ++  +   + D               
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262

Query: 476  LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 531
                     +EL  K+ +++  +++  ++R  L+  +GE   QL     LV  LS   QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313

Query: 532  TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 589
               + E    Q   ++ K   +L   + +     D L E   ++Q  +      L+KA  
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 590  -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 645
             +  ++  Y   +I   E+ E+   +LA  ++  +  ++ ++ +   L    Q  Q   +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430

Query: 646  IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 705
            +  L+ D+E + +      KK R                F   +++    C +    + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475

Query: 706  VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 765
              +E  +   +L          +  A EE             S    E L++    L   
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514

Query: 766  MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 825
            ++ L   + EG             VE     L+A + +AE     LE  E  I  ++  L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571

Query: 826  KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 885
                +  SE + +++  ++++D   ++    +E +Q+ L          + E     DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618

Query: 886  QADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
            +    ++E +  E++ +LN  ++   E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)

Query: 87   RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            R  +R +E    TL   ++   D  +LK     +L + +IQL       ++      + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653

Query: 140  RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
              LK+ +    +AL ++E   E++A              M E RA  LQ E+E L+  ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699

Query: 200  ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
            +     +I + E+ +       +S +++ L  QN            L +++K+    + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742

Query: 260  LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 315
            +  +    L+  R   E+ ++ ++ A    +ELK++ D +   E     M + + D  L 
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802

Query: 316  LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
            L+E  +                +RE  G++E+  + N E  +  R+ E  ++E       
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858

Query: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 413
            +  E +K +   Q+ V   Q  +K Y++     ++ +       R+L ++ E + ER   
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918

Query: 414  PPPETFDFKIKFAETKAHAKAIEME 438
               +    ++K  E   H K I  E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
            ++ LR+Q  DL+E+L  +  +    +A+++EL   +  LEQ +  +   +++  D   R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719

Query: 143  KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 190
            +    +    +  K++   +++     +E    +   AEE+           AE L++E 
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 191  -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 245
                 +E +K+ +++   DL++   E E+    G       KQ+++  AR+++    +  
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830

Query: 246  LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 305
               SE++ + +  K + K  + ++ +  Q E  ++ + + +  +D+L+ +V +     E 
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890

Query: 306  VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353
             E  ++ NL    K R+L+    +LE   E  D  +    +  ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
            + +E L+ Q+  +E +   L+ +  E +A L++ E+              ++QL   Q  
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727

Query: 128  -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
                 K K++   + +Q  +++  +EA+ A E  ++ + + A  A+ ++         E 
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787

Query: 183  RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
              ++++Q V+ L+ R+DE           +I K E   +  +G   S Q +  E      
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 237  KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 289
            K    R+++L+     +++  ++LQ L++K   +++  ++Q E  +E+    L++     
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906

Query: 290  DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 320
             EL+E  + A  AE  V  L  ++  +  KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 128
            L    K+ + L A+VR+LE ++E+ + + AE    +K L KH+        Q E+ ++  
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867

Query: 129  SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
             ++Q+    LQ ++K  +++A+EA E     + +       +E A       EERA+  +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920

Query: 189  QEVEALKERVDELTT 203
             +V  L+ +  E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 130
            +KE++ L+      E   +TL   +AE+  K+  L K KI+LEQ          QE K +
Sbjct: 999  TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051

Query: 131  MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 185
            M  ++A  +R+L+   K A+E+   +E +++ ++E     +  E++ L  ++ +E+A   
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108

Query: 186  SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 227
             LQ++++ L+ R++EL  ++E     +A+ E++ SD               G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168

Query: 228  QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 280
              +++ A  +      RDL  +  Q       L +K         ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225

Query: 281  ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
            E S+ +  ID+L   V+    A    E+M   L D+   L+ K  E +  + DL A    
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282

Query: 337  NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 395
               LQ  + E   +L E+  +     R  Q   +  +E     ++ IK    L   LQ  
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342

Query: 396  ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
                  +  +   +QE+  E Q+   +   E   ++ K+ ET A  +  E+E  + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401

Query: 447  ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 502
                A  H+  + A                             E  +++ Q + E     
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437

Query: 503  SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 559
             ER     AA   +Q +F   L       + T     HA  + S    + +G+ L+   +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492

Query: 560  AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 615
            A+E SLD L E L ++  +    +  LT+ I    K    L  I    + E C +Q A  
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549

Query: 616  IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
                + A   +  E G+ LR  L+  Q  +++   + + +     +++   +I   M  T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606

Query: 675  DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
                + A +                L  +   L      AA+ +      +G+L      
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662

Query: 735  L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 792
            L  A ++ E +           + +  N+L + + +L   +++ E   +    +      
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717

Query: 793  RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 844
            R   L  + T       KLE        + E +++E + + +   + +++A +    L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777

Query: 845  KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 898
            + D++A      K+ ++ ++ +Q RL+E + L  K  K+           I +LEA   E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827

Query: 899  LKQRLNSQSKRTIEGLRG 916
            L+  + S+ KR  E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            K+ + L+A++ +LEE++E  R  RA+ + +  +L +   +LE++ E   +++E       
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
            +++  +K  +EA   K R   E A        ATL K+ A+  AE L ++++ L+    +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
            L  +   +K EI++  S+    S     LE+    L+D L    +L S E+++   +  L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279

Query: 261  ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 310
                  ++ ++ E      ++E L  +LS+ +      I+ELK Q++  + A+  +    
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339

Query: 311  DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 358
              + +    L E+  E +E+  +L+ A+++ N E+ +       +A +   EL E     
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 359  GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 418
              R++ A++ VEA     A  ++T ++ +     L  ++ E TN   A+++++Q+   + 
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458

Query: 419  F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 471
              ++K K  ET A  +A + E R +     ++  A    +  L     ++        D 
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518

Query: 472  VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 529
               +    + I + E I+KQ  QEK EL     E    L    G+ L     L    S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578

Query: 530  QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 583
               +   +  + Q   +  + V S+   + A  RS +  I L  K     ++++  +N  
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638

Query: 584  -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 633
                 +A++ Y++   I      HL +     ED   QLA      +   + +  E+  L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694

Query: 634  RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 693
            RA L+  + +  IA      E    D  +  + +  +                   + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729

Query: 694  LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 753
            ++ +K L   ++ +Q        ++      E     A+ + A  A E      +S+  E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786

Query: 754  CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 810
             ++++      T+  L   + E E  A +   K    +E R   L  E+   +    +  
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843

Query: 811  --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
              L   E  +KE    L  + EE  +  +RL  L  KL +  K    + E+ + +     
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899

Query: 869  ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
            A  RK + E EE  +  +ADI + +  K  +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
            L    KE+     +V++L E++    ET+     E KA        L +L+  + ++  +
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026

Query: 125  QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 179
             + K K+++Q  DL+  L++ +K   +   AK +   ++    ++I     E   LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 180  AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 226
             ++  E  +LQ ++E        L++++ EL   +E L+ EIE + +  A +  Q     
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146

Query: 227  KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 264
            ++LEE + RL++A       + M            RDL  +  Q       L +K     
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206

Query: 265  ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 317
                ++++ +++ +++L++E S+ +  ID+L   V+    A    E+M   L D+   L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266

Query: 318  EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
             K  E +  + DL A       LQ  + E   +L E+  +     R  Q   +  +E   
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323

Query: 378  DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 427
              ++ IK    L   LQ        +  +   +QE+  E Q+   +   E   ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382

Query: 428  TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 480
            T A  +  E+E  + ++AQ    A  H+  + A    +  +  R   + + +++ +    
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442

Query: 481  LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 531
              C A   +++  +K   E  + C E    L  +  E  S    L      Y  SL Q  
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502

Query: 532  TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 581
            TL R    L Q   D+ +++            +  ++   +  L   +E        E  
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562

Query: 582  NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 635
             +  +   +   +      +AE+ E+      +HI+  +S    +  E+       RL+ 
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 694
             ++G          L ++E   +   +   +  R    T   GI         + D L  
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669

Query: 695  --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 752
              D ++ L  V      + A   +L A L + E     A +EL   ASE++         
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            + L      LI+T  KL T + + + + E    +    E +A   +  ITDA  +  +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776

Query: 813  DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 861
              +     L++  K   + + +  +RL   E+           KL++  ++ +  +E  Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836

Query: 862  TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 910
             R  E    LRK E+  +E     + D          +D+L+A+    K++     +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)

Query: 102  LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 161
            LK AE +   KE+   K + +++++  +K + ++ +L+ ++    KE  +     +   E
Sbjct: 846  LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902

Query: 162  EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 207
             +AD  +         I++    KE+ E  E  E +  E+ A K +++    EL  D++ 
Sbjct: 903  GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962

Query: 208  LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 267
            L+  + +   +  A+  ++K L E+ A L + + ++    + EK      + L E   Q 
Sbjct: 963  LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012

Query: 268  LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 326
            L+ ++ + +++   L++A+  +++  + ++ +L  E+ + M  +R    LE  ++  +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 327  VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 383
            + D+E  NE   +L E  ++ E E   L+ +++   A   + QK+++  Q  + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128

Query: 384  KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
            +  R   A  +    +L+ + E   ER ++    T     +    K      +   R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185

Query: 444  VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 501
             A  Q     + L     DS    G   D +  +        K +L +++++ K E+ + 
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237

Query: 502  CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 561
             S    +  A G        L   LS L++     +  ++    D+  + G L  E    
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293

Query: 562  ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 621
             R LD           ++   V  L++  + +         +Q E+   QL + IK   +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334

Query: 622  ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 678
               AL     +   LR   +  QE+   A L R L  + +++ Q+  K       TDA  
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385

Query: 679  IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 738
                     Q ++ L + +K L   +   +E   A     A L + +  L   +E+L   
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437

Query: 739  ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 798
                          E    +C  L          + E +   E   ++    +  A +L 
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 799  AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 858
             E+   +    +  D+   +K   K+L+ +  +L+E          +L+   K  ++   
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 859  KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
            ++Q  LEE +A L  +E +    +  ++ +++++D+  AEK E   +L     R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 916  GPPPSGIATLVSGIAGEEQQRG 937
                + I +    I  +++  G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)

Query: 88   AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
            A+ ++LEEK+ TL  ++              A+ + +  +L K KIQLE   +  ++  E
Sbjct: 874  AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933

Query: 134  QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
             + ++   L   +++ ++     ++ ++++  T   +E    +K   E + ++L +E+  
Sbjct: 934  DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            L E + +LT + + L+   ++   D  A   ++  L +   +L+  +  +      EK+ 
Sbjct: 991  LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050

Query: 254  HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 304
             + L++   K   +L++       +  ++++L E+L + E  I  L+ ++  + ALG   
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107

Query: 305  MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
                     + L++K++EL+  + +LE   E     +  A +   +L  +L+    R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

Query: 365  A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
            A      ++E  ++  A++Q+  +   + T   +     L  +   SV    +       
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218

Query: 421  FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 475
             K K  + K+  K   ME+  +      V++A  ++  +   + D               
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262

Query: 476  LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 531
                     +EL  K+ +++  +++  ++R  L+  +GE   QL     LV  LS   QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313

Query: 532  TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 589
               + E    Q   ++ K   +L   + +     D L E   ++Q  +      L+KA  
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372

Query: 590  -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 645
             +  ++  Y   +I   E+ E+   +LA  ++  +  ++ ++ +   L    Q  Q   +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430

Query: 646  IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 705
            +  L+ D+E + +      KK R                F   +++    C +    + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475

Query: 706  VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 765
              +E  +   +L          +  A EE             S    E L++    L   
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514

Query: 766  MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 825
            ++ L   + EG             VE     L+A + +AE     LE  E  I  ++  L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571

Query: 826  KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 885
                +  SE + +++  ++++D   ++    +E +Q+ L          + E     DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618

Query: 886  QADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
            +    ++E +  E++ +LN  ++   E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)

Query: 87   RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            R  +R +E    TL   ++   D  +LK     +L + +IQL       ++      + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653

Query: 140  RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
              LK+ +    +AL ++E   E++A              M E RA  LQ E+E L+  ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699

Query: 200  ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
            +     +I + E+ +       +S +++ L  QN            L +++K+    + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742

Query: 260  LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 315
            +  +    L+  R   E+ ++ ++ A    +ELK++ D +   E     M + + D  L 
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802

Query: 316  LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
            L+E  +                +RE  G++E+  + N E  +  R+ E  ++E       
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858

Query: 361  RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 413
            +  E +K +   Q+ V   Q  +K Y++     ++ +       R+L ++ E + ER   
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918

Query: 414  PPPETFDFKIKFAETKAHAKAIEME 438
               +    ++K  E   H K I  E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
            ++ LR+Q  DL+E+L  +  +    +A+++EL   +  LEQ +  +   +++  D   R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719

Query: 143  KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 190
            +    +    +  K++   +++     +E    +   AEE+           AE L++E 
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779

Query: 191  -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 245
                 +E +K+ +++   DL++   E E+    G       KQ+++  AR+++    +  
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830

Query: 246  LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 305
               SE++ + +  K + K  + ++ +  Q E  ++ + + +  +D+L+ +V +     E 
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890

Query: 306  VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353
             E  ++ NL    K R+L+    +LE   E  D  +    +  ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
            + +E L+ Q+  +E +   L+ +  E +A L++ E+              ++QL   Q  
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727

Query: 128  -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
                 K K++   + +Q  +++  +EA+ A E  ++ + + A  A+ ++         E 
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787

Query: 183  RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
              ++++Q V+ L+ R+DE           +I K E   +  +G   S Q +  E      
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 237  KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 289
            K    R+++L+     +++  ++LQ L++K   +++  ++Q E  +E+    L++     
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906

Query: 290  DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 320
             EL+E  + A  AE  V  L  ++  +  KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 128
            L    K+ + L A+VR+LE ++E+ + + AE    +K L KH+        Q E+ ++  
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867

Query: 129  SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
             ++Q+    LQ ++K  +++A+EA E     + +       +E A       EERA+  +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920

Query: 189  QEVEALKERVDELTT 203
             +V  L+ +  E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 178/905 (19%), Positives = 370/905 (40%), Gaps = 131/905 (14%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLETL-----RLKRAEDKAKLKELEKHKIQLEQVQEW 127
            + PL   ++ E+ +     D E   E L     R K  E+K      EK+ +QL+   E 
Sbjct: 840  IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899

Query: 128  KSKMQEQQA----------------DLQRRLKEARKEAKEALEAKERYMEEMADTA---- 167
            ++ M  ++                 +L  RL+E  +E    L AK+R +E+   +     
Sbjct: 900  ENLMDAEERCEGLIKSKILLEAKVKELTERLEE-EEEMNSELVAKKRNLEDKCSSLKRDI 958

Query: 168  DAIEMATL----DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 223
            D +E+       +K   E + ++L +E+ AL+E + +LT + + L+   ++   D     
Sbjct: 959  DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018

Query: 224  YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-------VRQQRE 276
             ++  L + NA+L+     +      EK+    L++   K   +L++       +   ++
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078

Query: 277  RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
            +++E+L + E  + +L+ ++D     +E V      +L  ++K++EL+  + +LE   E 
Sbjct: 1079 QIEEKLKKKEFELSQLQAKID-----DEQV-----HSLQFQKKIKELQARIEELEEEIEA 1128

Query: 337  NDELQENARETELELREQLDMAGARVREA----QKRVEAAQETVADYQQTIKKYRQLTAH 392
               L+    +   +L  +L+    R+ EA      ++E  ++  A++Q+  +   + T  
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 393  LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
             +     L  +Q  SV    +        K K  + K+  K        ME+     ++ 
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK--------MEIDDMASNIE 1240

Query: 453  LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAA 512
             L      S  +   +  C  V      +  K E   +Q Q   +L+   +      G  
Sbjct: 1241 AL------SKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIHDLNMQKARLQTQNGEL 1291

Query: 513  GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELL 572
              ++     L+  L+  +  L +    L +   +  K   ++   + +     D L E  
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351

Query: 573  HKDQLDETVNVEPLTKA---IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALD-- 624
             ++Q  +      L+KA   +  ++  Y   +I   E+ E+   +LA  ++  +   +  
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411

Query: 625  ---CMSVEVGRLRAFLQGGQEATDIALLLRDLE---TSCSDI----RQFCKKI---RRRM 671
               C S+E  + R  LQG     ++  L+RDLE   T+C+ +    R F K +   ++++
Sbjct: 1412 NSKCASLEKTKQR--LQG-----EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464

Query: 672  PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
              + A  + AA      +S  L   R     VV  L+ +            EN+      
Sbjct: 1465 DESQAE-LEAAQKESRSLSTELFKMRNAYEEVVDQLETLR----------RENKN----- 1508

Query: 732  LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 791
            L+E     +EQI  T  +   +   ++  ++    + L  A++E E   E   SK   V+
Sbjct: 1509 LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566

Query: 792  LRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---EANVR----LSLLEK 844
            L  + +++E      L  K+ +++  I++LK++ +   E L    +A +R       L+K
Sbjct: 1567 LELSQVKSE------LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620

Query: 845  KLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLN 904
            K++    + + ++     ++ ETQ  LR  + + +++    Q  +D       +LK++L 
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS----QLHLDDALRSNEDLKEQLA 1676

Query: 905  SQSKR 909
               +R
Sbjct: 1677 IVERR 1681



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 193/967 (19%), Positives = 398/967 (41%), Gaps = 165/967 (17%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLR---LKRAEDKAKLKELEKHKIQLEQVQEWK---- 128
            L    KE+     +V++L E++  L     K  ++K  L+E  +  +   QV+E K    
Sbjct: 965  LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024

Query: 129  ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-------------- 170
                +K+++Q  DL+  L++ +K   +   AK +   ++  + ++I              
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084

Query: 171  -----EMATLDKEMAEERAESLQ--QEVEALKERVDELTTDLEI---LKAEIEEKGSDGA 220
                 E++ L  ++ +E+  SLQ  ++++ L+ R++EL  ++E    L+A+IE++ SD A
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144

Query: 221  ASSYQLKQLEEQNARLKDALVRM------------RDLSSSEKQEHVKLQKLMEKKNQEL 268
                ++ +  E+ +    A + M            RDL  +  Q       L +K+   +
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204

Query: 269  EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 328
              + +Q + LQ    + E    ELK ++D        +E L+    N+E   R + +   
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEID---DMASNIEALSKSKSNIERTCRTVEDQFS 1261

Query: 329  DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR- 387
            +++A +E   +L  +    +  L+ Q      RV E +  +    ++     Q +++ + 
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321

Query: 388  ----------------QLTAHLQDVNRE-LTNQQEASVERQQ---QPPPETFDFKIKFAE 427
                            Q + H  D+ RE    +QEA  E Q+   +   E   ++ K+ E
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY-E 1380

Query: 428  TKAHAKAIEMELRQMEVAQANRHMSLLT-------AFMPDSFLRPGGDHDCVLVLLLMPR 480
            T A  +  E+E  + ++AQ  +     T       A +  +  R  G+ + ++  L    
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440

Query: 481  LICKAELIRKQ-------AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATL 533
              C A L +KQ       A+ K +L E+ +E   L  A  E  S +  L    +  +  +
Sbjct: 1441 TAC-ATLDKKQRNFDKVLAEWKQKLDESQAE---LEAAQKESRSLSTELFKMRNAYEEVV 1496

Query: 534  HRYEHALSQCSVDVYKKVGSLYPEMSAHERSL---DFLIELLHKDQLDETVNVEPLTKAI 590
             + E  L + + ++ +++  L  +++   ++L   +   +L+ +++ D  V +E +  ++
Sbjct: 1497 DQLE-TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555

Query: 591  KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALL 649
            ++          E+ +   +QL   +   +S LD   +E    +    +  Q A +    
Sbjct: 1556 EH----------EESKILRVQL--ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603

Query: 650  LRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQE 709
            + D E      R    +++++M G D   +   L    +    + + +KHL  V   L++
Sbjct: 1604 VLDAEIRS---RNDALRLKKKMEG-DLNEMEIQLGHSNR---QMAETQKHLRTVQGQLKD 1656

Query: 710  VAAAA----------AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC 759
                            + +A +    GLL+  LEE+   A EQ   T   S  E L  S 
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV-ALEQTERTRRLSEQELLDASD 1715

Query: 760  NI---------LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLK 810
             +         LI+T  KL   + + + + E    +    E +A   +  ITDA  +  +
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKA---KKAITDAAMMAEE 1772

Query: 811  L---EDRETVIKELKKSLK-----------------IKG--EELSEANVRLSLLEKKLDS 848
            L   +D    ++ +KK+L+                 +KG  +++ +   R+  LE +LD 
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832

Query: 849  AAKDADERIE---KVQTRLEETQALLRKKEKEF---EETMDALQADIDQLEAEKAELKQR 902
              K   E ++   K + +++E      +  K     ++ +D LQA +   + +  E +++
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892

Query: 903  LNSQSKR 909
             N+Q  R
Sbjct: 1893 ANTQLSR 1899



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 69/326 (21%), Positives = 138/326 (42%), Gaps = 38/326 (11%)

Query: 92   DLEEKLETLRLKRAEDKAKLKELE----KHKIQLEQVQEWKSKMQEQQADLQRRLKEA-- 145
            ++  + + LRLK+  +   L E+E        Q+ + Q+    +Q Q  D Q  L +A  
Sbjct: 1608 EIRSRNDALRLKKKME-GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666

Query: 146  -RKEAKEALEAKER----YMEEMADTADAIEMATLDKEMAE-------ERAESLQQEVEA 193
              ++ KE L   ER     +EE+ +   A+E     + ++E       +R + L  +  +
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726

Query: 194  LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            L     +L  D+   +AE+E    +   +  + K+     A + + L + +D S+  ++ 
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786

Query: 254  HVKLQKLMEKKNQELEVVRQ--------QRERLQEELSQAESTID-ELKEQVDAALGAEE 304
               L++ ++     L+   Q        Q ++L+  + + E+ +D E K   +A  GA +
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846

Query: 305  MVEMLTDRNLNLEE---KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGAR 361
                + +     EE    +  L++ V  L+A      +++   R+ E E  EQ +   +R
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQA------KVKSYKRQAE-EAEEQANTQLSR 1899

Query: 362  VREAQKRVEAAQETVADYQQTIKKYR 387
             R  Q  +E A E     +  + K R
Sbjct: 1900 CRRVQHELEEAAERADIAESQVNKLR 1925



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/275 (20%), Positives = 123/275 (44%), Gaps = 44/275 (16%)

Query: 90   VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEA 149
            +R  E+  E L +    +   L+ELE+ K+ LEQ +  +   +++  D   R++    + 
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724

Query: 150  KEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE------VE 192
               +  K++   ++A     +E +  +   AEE+           AE L++E      +E
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784

Query: 193  ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL------------ 240
             +K+ +++   DL+    E E+    G     Q+++LE +   L++ L            
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKK--QIQKLENRVRELENELDVEQKRGAEALK 1842

Query: 241  ------VRMRDLSSSEKQEH---VKLQKLMEKKNQELEVVRQQRERLQE----ELSQAES 287
                   ++++++   +++H   ++LQ L++K   +++  ++Q E  +E    +LS+   
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902

Query: 288  TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE 322
               EL+E  + A  AE  V  L  ++ ++  +  E
Sbjct: 1903 VQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 34/156 (21%), Positives = 71/156 (45%), Gaps = 49/156 (31%)

Query: 810  KLEDRETVIKELKKSLKIKGEELSEANVRLSLL----------EKKLDS----------- 848
            +LE+ +  +++ +++ ++  +EL +A+ R+ LL          +KKL++           
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747

Query: 849  ---AAKDADERIEKVQT----------RLEETQALLRKKEKEFEETMDALQADIDQ---- 891
                +++A+E+ +K  T          + ++T A L + +K  E+T+  LQ  +D+    
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807

Query: 892  -----------LEAEKAELKQRLNSQSKRTIEGLRG 916
                       LE    EL+  L+ + KR  E L+G
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 3/103 (2%)

Query: 813  DRETVIKELKKSLKIKGEELSEANVRLS---LLEKKLDSAAKDADERIEKVQTRLEETQA 869
            D E   +++++ LK K  ELS+   ++    +   +     K+   RIE+++  +E    
Sbjct: 1072 DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131

Query: 870  LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
            L  K EK+  +    L+   ++LE        ++    KR  E
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 99/400 (24%), Positives = 192/400 (48%), Gaps = 48/400 (12%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQ 134
            L   ++++  L +++R LEE+  +L+ ++ E++   K LEK  + L+ Q+ + K K+ + 
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383

Query: 135  QADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMA--TLDKEMAE-----ERAESL 187
               ++  L+EA+K+  +  EA  + +EE A   D +E     L +E+ +     +    +
Sbjct: 1384 LGTIE-SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442

Query: 188  QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR-LKDALVRMRDL 246
               +E  +++ D+L  + + + A   E+     A + + +      AR L++AL    + 
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502

Query: 247  SSSEKQEHVKLQKLMEKKN------QELEVVRQQRERLQEEL-SQAESTIDELKEQVDAA 299
                KQ    ++ LM  K+       ELE  ++  E+  EE+ +Q E   DEL+   DA 
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562

Query: 300  LGAEEMVEM--------LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351
            L  E  ++         L  R+   EEK R L + V +LEA  E+ DE ++ A     + 
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA--ELEDERKQRALAVASKK 1620

Query: 352  REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
            + ++D+     ++ + ++EAA +      + IK+ R+L A ++D  REL   +EA   R 
Sbjct: 1621 KMEIDL-----KDLEAQIEAANKA---RDEVIKQLRKLQAQMKDYQREL---EEARASRD 1669

Query: 412  QQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANR 449
                    +   +  E++   K++E E+ Q+  E+A + R
Sbjct: 1670 --------EIFAQSKESEKKLKSLEAEILQLQEELASSER 1701



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 177/882 (20%), Positives = 353/882 (40%), Gaps = 148/882 (16%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            L+AQ+ +L+E  E+ +  R + + + +    ELE  K +LE   +  +  QE +   ++ 
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 142  LKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
            + E +K  +E  +  E  +++M    A A+E  +   E A+    +L++  + L+    E
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 201  LTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
            L  ++++L   KAE E K     A   +L     +  RL+  L           ++  KL
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA----------EKASKL 1285

Query: 258  QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 317
            Q  ++  +  LE   ++  +  ++ +  ES + +           +E+++  T + LNL 
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD----------TQELLQEETRQKLNLS 1335

Query: 318  EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV----------REAQK 367
             ++R+L E    L+   E  +E ++N  +  L L+ QL     +V           EA+K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 368  RV--------EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE--ASVERQQ----Q 413
            ++        +  +E    Y +  K   +L   L D+  +L +Q++  +++E++Q    Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 414  PPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
               E      ++AE   +A A+A E E + + +A+A                        
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARA------------------------ 1491

Query: 472  VLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQA 531
                 L   L  K E  R+  Q + ++ +  S +  +     E       L   +  ++ 
Sbjct: 1492 -----LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546

Query: 532  TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIK 591
             L   E  L Q + D       L  E++       F  +L  +D+ +E    E     IK
Sbjct: 1547 QLEELEDEL-QATED-----AKLRLEVNMQAMKAQFERDLQTRDEQNE----EKKRLLIK 1596

Query: 592  YYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLL 650
              + L    L ++ +   + +A   K        M +++  L A ++   +A D +   L
Sbjct: 1597 QVREL-EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQL 1647

Query: 651  RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
            R L+    D ++  ++ R               A   ++     +  K        L+ +
Sbjct: 1648 RKLQAQMKDYQRELEEAR---------------ASRDEIFAQSKESEKK-------LKSL 1685

Query: 711  AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLA 770
             A   QL   LA +E     A +E    A E    T S+S    L      L + + +L 
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEI---TNSASGKSALLDEKRRLEARIAQLE 1742

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
              ++E + + E    +     L+   L AE+        K ++    ++   K LK K +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 831  EL------------SEANVRLSLLEKKLDSAAKD---ADERIEKVQTRLEETQALL---R 872
            EL            S    ++  LE++L+  AK+   A++ + + + +L+E    +   R
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862

Query: 873  KKEKEFEETMDALQADIDQL--EAEKAELKQRLNSQSKRTIE 912
            +   +++E M+   A + QL  + E+AE +    + S+R ++
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 215/1082 (19%), Positives = 426/1082 (39%), Gaps = 181/1082 (16%)

Query: 73   VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-KHKIQLEQVQEWKSKM 131
            V PL   +++EE L+A+    +E+L  ++ K+ + + +L+E+E KH+  LE+       +
Sbjct: 841  VKPLLQVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE-----KNI 891

Query: 132  QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191
              +Q   +  L    +E +  L AK++ +EE+    ++        E  EER + LQ E 
Sbjct: 892  LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES------RVEEEEERNQILQNEK 945

Query: 192  EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 241
            + ++  + +L   L+  +   ++   +   +  ++K++EE+   L+D             
Sbjct: 946  KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005

Query: 242  -RMRDLSSSEKQEHVKLQKLM--------------------EKKNQELEVVRQQRE---- 276
             R+ + SS   +E  K + L                     EK  QELE  +++ +    
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065

Query: 277  RLQEELSQAESTIDELKEQV----DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
             LQ+++++ ++ IDELK Q+    +   GA    +  T    N  + VREL+  + +L+ 
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 333  MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
              E     +  A + + +L E+L+         +  +E   +T A  Q+   K  Q  A 
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELE-------ALKTELEDTLDTTAAQQELRTKREQEVAE 1178

Query: 393  LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
            L+    E T   EA ++  +Q                 HA A+E    Q+E  QA R  +
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQ----------------RHATALEELSEQLE--QAKRFKA 1220

Query: 453  LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK-QAQEKFELSENCSERPGLRGA 511
             L         + G + D          L C+ +++++ +A+ + +  +  ++   L   
Sbjct: 1221 NLEK------NKQGLETD-------NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267

Query: 512  AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
              E       L    S LQ  L      L +      KK      + ++ E  L    EL
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAE----KKGIKFAKDAASLESQLQDTQEL 1323

Query: 572  LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
            L +++  + +N+    + ++  ++       E+ E+    L   +   QS L     +V 
Sbjct: 1324 L-QEETRQKLNLSSRIRQLEEEKNSLQ-EQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381

Query: 632  RLRAFLQGGQEATDIALLLRDLETSCSDIRQFC------KKIRRRMPGTDAPGIPAALAF 685
                 ++  +EA     LL+D E     + +        +K + R+   +   +   L  
Sbjct: 1382 DDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ-QELDDLTVDLDH 1438

Query: 686  GPQVSDTLLDCRKHLTWVVAVLQEVAAA------AAQLIAPLAENEGLLVAALEELAFKA 739
              QV+  L   +K    ++A  + ++A        A+  A   E + L +A   E A +A
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498

Query: 740  SEQIYGTPSSSPYEC----------------LRQSCNILISTMNKLATAMQEGEYDAERP 783
             E+          +                 L +S   L   + ++ T ++E E + +  
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558

Query: 784  PSKPPPVELRAAALRAEI-TDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
                  +E+   A++A+   D +    + E+++ ++ +  + L+ + E+  +        
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618

Query: 843  EKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLEAEKAEL 899
            +KK++   KD + +IE      +E    LRK +   K+++  ++  +A  D++ A+  E 
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678

Query: 900  KQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLL 959
            +++L S     ++         +A+        EQ+R  +  +   S  G         L
Sbjct: 1679 EKKLKSLEAEILQ-----LQEELASSERARRHAEQERDELADEITNSASG------KSAL 1727

Query: 960  LQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTS 1019
            L +   +   I+QL+ E                       L  E    EL     +RKT+
Sbjct: 1728 LDEKRRLEARIAQLEEE-----------------------LEEEQSNMEL-LNDRFRKTT 1763

Query: 1020 QLLETLN-QLSTHTHVVDITRTSPAAKSPSA--QLMEQVAQLKSLSDTVEKLKDEVLKET 1076
              ++TLN +L+           S A KS +A  QL  Q  +LK+    +E       K T
Sbjct: 1764 LQVDTLNAELA--------AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815

Query: 1077 VS 1078
            +S
Sbjct: 1816 IS 1817



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 185/977 (18%), Positives = 402/977 (41%), Gaps = 103/977 (10%)

Query: 82   EEEGLRAQVRDLEEKLET-------LRLKRAEDKAKLKELEKHKIQLEQVQ----EWKSK 130
            E++ ++A ++DLEE+L+        L+L++   +AK+K++E+  + LE       + K  
Sbjct: 944  EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003

Query: 131  MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
            M+++ A+   +L E  ++AK   + + +    ++D  + ++     ++  E+    L  E
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063

Query: 191  VEALKERVDELTTDLEILKAEIEEKGSD--GAASSYQLKQLEEQNA-----RLKDALVRM 243
               L++++ EL   ++ LK ++ +K  +  GA +    + L + NA      L+  +  +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123

Query: 244  RDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRE------RLQEEL-SQAESTIDELKEQV 296
            ++   SEK    K +K     ++ELE ++ + E        Q+EL ++ E  + ELK+ +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183

Query: 297  DAAL-GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDE-LQENARETELELREQ 354
            +      E  ++ +  R+    E++ E  E     +A  E N + L+ + +E   E++  
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV- 1242

Query: 355  LDMAGARVREAQKRVEA-AQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
            L    A     +K+++A  QE  A   +  +   +L      +  EL N      E +++
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302

Query: 414  PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP-----DSFLRPGGD 468
                     IKFA+  A  ++   + +++   +  + ++L +         +S      +
Sbjct: 1303 G--------IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 469  HDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLS- 527
             +     L    L  +++L    A  K ++ ++      L  A  + L  A  L   L  
Sbjct: 1355 EEEARKNLEKQVLALQSQL----ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410

Query: 528  ------LLQATLHRYEHALSQCSVDV---------YKKVGSLYPEMSAHERSLDFLIELL 572
                   L+ T +R +  L   +VD+          +K    + ++ A E+S    I   
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISAR 1466

Query: 573  HKDQLD--ETVNVEPLTKAIKYYQHLY-SIHLAEQPEDCTMQLADHIKFTQSALDCMSVE 629
            + ++ D  E    E  TKA+   + L  ++   E+ E    QL   ++   S+ D +   
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526

Query: 630  VGRLRAFLQG-GQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQ 688
            V  L    +   Q+  ++   L +LE    D  Q  +  + R+   +   + A      Q
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELE----DELQATEDAKLRLE-VNMQAMKAQFERDLQ 1581

Query: 689  VSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS 748
              D   + +K L     ++++V    A+L     +   L VA+ +++     +       
Sbjct: 1582 TRDEQNEEKKRL-----LIKQVRELEAEL-EDERKQRALAVASKKKMEIDLKDL------ 1629

Query: 749  SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLG 808
             +  E   ++ + +I  + KL   M++ + + E   +    +  ++     ++   E   
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689

Query: 809  LKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
            L+L++     +  ++  + + +EL++     +  +  L    +  + RI +++  LEE Q
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 869  ALLRKKEKEFEET---MDALQADI--DQLEAEKA----ELKQRLNSQSKRTIEGLRGPPP 919
            + +      F +T   +D L A++  ++  A+K+    +  +R N + K  ++ L G   
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809

Query: 920  SGIATLVSGIAG-----EEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQL- 973
            S     +S +       EEQ       +A  +       K    +  Q+   R H  Q  
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869

Query: 974  -QHENSILKGAQMKASL 989
             Q E +  +  Q+K  L
Sbjct: 1870 EQMEKANARMKQLKRQL 1886



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 85/345 (24%), Positives = 152/345 (44%), Gaps = 26/345 (7%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            K+   L+AQ++D + +LE  R  R E  A+ KE EK   +L+ ++    ++QE+ A  +R
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK---KLKSLEAEILQLQEELASSER 1701

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA--EERAESLQQEVEALKERV 198
              + A +E  E   A E        +A   E   L+  +A  EE  E  Q  +E L +R 
Sbjct: 1702 ARRHAEQERDEL--ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759

Query: 199  DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK-L 257
             + T  ++ L AE+  + S    S    +QLE QN  LK  L  +     S+ +  +  L
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819

Query: 258  QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV-DAALGAEEMVEMLTDRNLNL 316
            +  + +  ++LE   ++R    + + + E  + E+  QV D    A++  E +   N  +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879

Query: 317  EEKVRELRETVGDLEAMNEMNDELQ---ENARETELELREQLDMAGARVREAQKRVEAAQ 373
            ++  R+L E   +    N    +LQ   ++A E    L  ++     R+R          
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------ 1933

Query: 374  ETVADYQQTIKKYRQLTAHLQDVNRELTN---QQEASVERQQQPP 415
                 +  +    RQL  HL+  + EL++   + + S   + QPP
Sbjct: 1934 ---ISFSSSRSGRRQL--HLEGASLELSDDDTESKTSDVNETQPP 1973



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 99/442 (22%), Positives = 191/442 (43%), Gaps = 87/442 (19%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQ 139
            K    L    R LE+++E +R +  E + +L+  E  K++LE  +Q  K++ +    DLQ
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQ 1581

Query: 140  RRLKEARKEAKEALEAKERYME-EMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
             R  E  +E K  L  + R +E E+ D      +A   K+  E   + L+ ++EA  +  
Sbjct: 1582 TR-DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640

Query: 199  DELTTDLEILKAEI--------------EEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
            DE+   L  L+A++              +E  +    S  +LK LE +  +L++ L    
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700

Query: 245  DLSSSEKQEHVKL-----------QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 293
                  +QE  +L             L+++K +    + Q  E L+EE S  E   D  +
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760

Query: 294  E---QVD---AALGAEEMVEMLTD--------RNLNLEEKVREL--------RETVGDLE 331
            +   QVD   A L AE      +D        +N  L+ K++EL        + T+  LE
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820

Query: 332  A-MNEMNDELQENARE----------TELEL-----------------REQLDMAGARVR 363
            A + ++ ++L++ A+E          TE +L                 +EQ++ A AR++
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880

Query: 364  EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKI 423
            + ++++E A+E       + +K ++      + N  L+ +      R ++  P      I
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------I 1934

Query: 424  KFAETKAHAKAIEMELRQMEVA 445
             F+ +++  + + +E   +E++
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS 1956


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 184/884 (20%), Positives = 340/884 (38%), Gaps = 109/884 (12%)

Query: 77   PSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQA 136
            PS    E  L  +  +     E L  ++ E +   KEL+  K  L+Q ++ +  ++ Q  
Sbjct: 387  PSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVM 446

Query: 137  DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK- 195
            +LQ +LK  +        AKE  ++++ +T + +E     K+  EE+    ++E+ ALK 
Sbjct: 447  ELQNKLKHVQGPEP----AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKG 502

Query: 196  ---ERVDELTTDLEILKAEIEE------KGSDGAASSYQLKQLEEQNARLKDALVRMRDL 246
               E V     ++E ++ + +       +    A   + + + E Q      ALVR    
Sbjct: 503  ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKM---SALVRGLQR 559

Query: 247  SSSEKQEHVKLQKLMEKKN--------QELEVVRQQRERLQEELSQAESTIDELKEQVDA 298
               E  E     + M +KN        QEL  +R ++E ++EEL +    +    EQ  A
Sbjct: 560  ELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619

Query: 299  ALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELR-EQLDM 357
            + G    VE+L    L  +E+++EL+            + E+    R+ ELE +   L +
Sbjct: 620  SAGDTRQVEVLKKELLRTQEELKELQ--------AERQSQEVAGRHRDRELEKQLAVLRV 671

Query: 358  AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
               R RE +++    Q+T+   +Q  ++  +    + +    +  Q+ A+VE   +   E
Sbjct: 672  EADRGRELEEQNLQLQKTLQQLRQDCEEASK-AKMVAEAEATVLGQRRAAVETTLRETQE 730

Query: 418  TFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLL 477
              D      E +     +E +L++                     L  GG+        +
Sbjct: 731  END------EFRRRILGLEQQLKETR------------------GLVDGGE-------AV 759

Query: 478  MPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE----QLSFAAGLVYSLSLLQATL 533
              RL  K + +  + Q+  E      E  G   AA      +L  A   +  L   Q TL
Sbjct: 760  EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819

Query: 534  HRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 593
            +R      +    + +    L  +    +R++D L + L K   D    ++ L   ++ Y
Sbjct: 820  NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879

Query: 594  QHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDL 653
            +      +A+         A   + T   L  +  E+ RLR  LQ  Q   D A L ++L
Sbjct: 880  KEKARREVADAQRQ-AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938

Query: 654  ETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAA 713
                         + +R+ G +            +  D      K L   V+ L+     
Sbjct: 939  -------------LAQRLQGLEQEA-----ENKKRSQDDRARQLKGLEEKVSRLETELDE 980

Query: 714  AAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC---NILISTMNKLA 770
                +  L +        +++L    +E +    +    EC + S    N  + T    +
Sbjct: 981  EKNTVELLTDRVNRGRDQVDQL---RTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037

Query: 771  TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
               Q+      +  S+   ++ R  A   E T  +    KLE +   +KEL   ++ + +
Sbjct: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK---VKELSIQIEDERQ 1094

Query: 831  ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADID 890
             +++   +LSL  K L     +A+E IE    RL+  +   +++ +E  E  + LQA I 
Sbjct: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIE----RLDGLRKKAQREVEEQHEVNEQLQARIK 1150

Query: 891  QLEAEKAELKQRLNSQSKRTIEGLRGP-------PPSGIATLVS 927
             LE +      R  ++S    EGL           PS IA+L++
Sbjct: 1151 SLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLT 1194



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 89/346 (25%), Positives = 159/346 (45%), Gaps = 44/346 (12%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK----HKIQLEQVQ----EW 127
            L    K+ E LR    +LEE+   L   R  D+   KELEK     K  L+Q+Q    ++
Sbjct: 823  LEEEGKQREVLRRGKAELEEQKRLL--DRTVDRLN-KELEKIGEDSKQALQQLQAQLEDY 879

Query: 128  KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM-------ATLDKEMA 180
            K K + + AD QR+ K+   EA++      R  +E+     A++        A LDKE+ 
Sbjct: 880  KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939

Query: 181  EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
             +R + L+QE E  K   D+    L+ L+ ++    ++       ++ L ++  R +D +
Sbjct: 940  AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQV 999

Query: 241  VRMRDLSSSEK--QEHVKLQKL-MEKKNQELEVVRQQRERLQE---ELSQAESTIDELKE 294
             ++R     E+  ++ ++  K+ +E++N++L+      E  Q+    LSQ ES    L+E
Sbjct: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059

Query: 295  QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQ 354
            ++ A    E    +L   N  LE KV+EL           ++ DE Q         + +Q
Sbjct: 1060 RLQAE---EREKTVLQSTNRKLERKVKELSI---------QIEDERQH--------VNDQ 1099

Query: 355  LDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL 400
             D    RV+  +++V+ A+E +       KK ++      +VN +L
Sbjct: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 85/386 (22%), Positives = 169/386 (43%), Gaps = 65/386 (16%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKLETLR-------LKRAEDKAKLKELEKHKIQLEQVQEWK 128
            L    +E +  R ++  LE++L+  R          A  + KL+ LE  K QLE+     
Sbjct: 725  LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN-A 783

Query: 129  SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
            S+ +E      +R  EAR E  EA     R  +E      A+E     +E+       L+
Sbjct: 784  SQEEEGSLAAAKRALEARLE--EAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841

Query: 189  QEVEALKERVDELTTDLE-----------ILKAEIEEK------------------GSDG 219
            ++   L   VD L  +LE            L+A++E+                    S+ 
Sbjct: 842  EQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEA 901

Query: 220  AASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK-LMEKKNQELEVVRQQRERL 278
              +S  L +L+++  RL+ AL      +S  +++  +L K L+ ++ Q LE   + ++R 
Sbjct: 902  EKTSGGLSRLQDEIQRLRQAL-----QASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956

Query: 279  QEELSQAESTIDELKEQVDAALGAEE-MVEMLTDRNLNLEEKVRELRETV-------GDL 330
            Q++ ++    ++E   +++  L  E+  VE+LTDR     ++V +LR  +        DL
Sbjct: 957  QDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL 1016

Query: 331  EAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETV--ADYQQTI----- 383
            E  ++++ E Q    +T L   E      A + + + + +  QE +   + ++T+     
Sbjct: 1017 EC-DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTN 1075

Query: 384  ----KKYRQLTAHLQDVNRELTNQQE 405
                +K ++L+  ++D  + + +Q++
Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKD 1101



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 36/197 (18%)

Query: 762 LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKEL 821
           L+ T  +L     E +        +   +E + A LR E       G +LE++   +++ 
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR----GRELEEQNLQLQKT 689

Query: 822 KKSLKIKGEELSEANV-----------RLSLLEKKLDSAAKDADE---RIEKVQTRLEET 867
            + L+   EE S+A +           R + +E  L    ++ DE   RI  ++ +L+ET
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET 749

Query: 868 QALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ---------SKRTIEGLRGPP 918
           + L+   E       D LQ    +LEAEK +L++ LN+          +KR +E      
Sbjct: 750 RGLVDGGEAVEARLRDKLQ----RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805

Query: 919 PSGIATLVSGIAGEEQQ 935
             G+A L     G+EQQ
Sbjct: 806 QRGLARL-----GQEQQ 817


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 84/374 (22%), Positives = 180/374 (48%), Gaps = 16/374 (4%)

Query: 82  EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 139
           E + L  +++ +  KL+  +++  E   +L + ++ K+  Q E++QEW+ K+QEQ+  + 
Sbjct: 327 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 384

Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
           R  +E  +E +E +  +E  M E  +     E    +KE    R E +  E E     ++
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444

Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
           E   + E ++ E EEK  +      Q K+ +EQ A++     ++R+     +++  K+ +
Sbjct: 445 EKMHEQEKIR-EQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQEEKMWR 502

Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE---QVDAALGAEEMVEMLTDRNLNL 316
             EK +++ ++  +++ + QEE+ + E  I E +E   Q +     EE +    ++    
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562

Query: 317 EEKVRELRETVGDLE----AMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
           EEK+ +  E + + E       E   E +E  RE E ++REQ +M   +  +  ++ E  
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622

Query: 373 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ---QQPPPETFDFKIKFAETK 429
            E     Q+  +K R+    +++  +++  Q+E   E++   Q+   + ++ + K  E +
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682

Query: 430 AHAKAIEMELRQME 443
              +  E ++R+ E
Sbjct: 683 EKMQEQEEKMRRQE 696



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 70/367 (19%), Positives = 170/367 (46%), Gaps = 19/367 (5%)

Query: 89  QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKE 148
           ++++ EEK++    K  E + K++E E+   + E++   K +   +Q ++    +E  + 
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428

Query: 149 AKEALEAKERYMEEMADTADAIEMATLDKEMAEE----RAESLQQEVEALKERVDELTTD 204
            +E +  KE  + E+ +     E     +E  +E    R +  +QE EA   R +E   +
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488

Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
            E    E EEK        ++ +++ E+  R ++     R      +QE +  QK  EK 
Sbjct: 489 QEEKIREQEEKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIREQEEIWRQK--EKI 545

Query: 265 NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELR 324
           +++ E +R+Q E++  +  +     ++++EQ +     EE +          EEK+RE  
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR-------EQEEKIREQE 598

Query: 325 ETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 384
           E + + E M +  +E      E   E  E++     ++R  ++++   ++ + + ++ I+
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658

Query: 385 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 444
           +  ++   +Q+   ++  Q+E   E++++   +  + K++  E K   + + +  ++ ++
Sbjct: 659 EQEEM---MQEQEEKMWEQEEKMCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKM 713

Query: 445 AQANRHM 451
            +   H+
Sbjct: 714 QEHQEHL 720



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 46/381 (12%)

Query: 68  TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 127
           TS G   P        +   A  R+LE ++ T+R+   + K +L+      + L   Q  
Sbjct: 161 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 213

Query: 128 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 173
             +++ +  DL  RL ++ K   E ++AL A        +RY+EE+    DA+ +     
Sbjct: 214 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273

Query: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 217
           T+  E  +E+   LQ++++ ++    E+  +++ LK                AE +  G 
Sbjct: 274 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 333

Query: 218 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 272
           +  + S +L+   E+N  L + L + ++     ++E +     K+Q+  EK  ++ E +R
Sbjct: 334 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392

Query: 273 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
           +Q E+++ +        ++++ Q +     EE +    +     EEK+REL E + + E 
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452

Query: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
           + E  ++ QE  +  E E R++ +   A++   ++++   +E + + ++ + +  +    
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509

Query: 393 LQDVNRELTNQQEASVERQQQ 413
            + +  E   Q++  + RQ++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEE 530



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 76/322 (23%), Positives = 163/322 (50%), Gaps = 29/322 (9%)

Query: 81  KEEEGLRAQVRDLEEKLETLRL--KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
           ++EE +R Q   + EK E +R   ++  ++ K++E E+ + + E+++E + K QEQ+A +
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKM 479

Query: 139 QRRLKEARKEAKEALEAKERY--MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
            R+ ++ R++ ++  E +E+    EE     + I     ++E  +E+ E  +QE E ++E
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQE-EKIRE 534

Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 256
           + +E+    E +  E EEK          +++ EE+  R ++   +M D     +++  K
Sbjct: 535 Q-EEIWRQKEKIH-EQEEK----------IRKQEEKMWRQEE---KMHDQEEKIREQEEK 579

Query: 257 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 316
           + +  EK  ++ E +R+Q E+++E+    +   +++ EQ +     EE ++   ++    
Sbjct: 580 VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639

Query: 317 EEKVRE----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
           EEK+RE    +RE    +    EM  E +E   E E ++ EQ +    +  + +++ E  
Sbjct: 640 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 699

Query: 373 QETVADYQQTIKKYRQLTAHLQ 394
            E     +Q  +K ++   HL+
Sbjct: 700 WEQEVRLRQQEEKMQEHQEHLE 721



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 68/299 (22%), Positives = 150/299 (50%), Gaps = 29/299 (9%)

Query: 89  QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 136
           ++R+LEEK+ E  +++  E+K     K++E EK + Q        E+++E + K++EQ+ 
Sbjct: 439 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 498

Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 193
            + R+ ++  ++ K   E K +  EEM    + I   E     KE   E+ E ++++ E 
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558

Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
           +  + +++    E ++ + E+          Q +++ EQ  ++++     ++      ++
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618

Query: 254 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
             K+ +  EK  ++ E +R+Q E+++E+  +     ++++EQ       EEM++   ++ 
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKM 671

Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
              EEK+ E  E + + E   E     +E   E E+ LR+Q +    +++E Q+ +EAA
Sbjct: 672 WEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHLEAA 723



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 75/340 (22%), Positives = 158/340 (46%), Gaps = 22/340 (6%)

Query: 81  KEEEGLRAQVRDLEEKLETLRLKRA---EDKAKLKELEKHKIQLEQ-VQEWKSKMQEQQA 136
           ++EE +R Q   + EK E +R +     E + K++  E+   + E+ ++E + KM EQ+ 
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE- 451

Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
             + R +E +++ +E +  +E+  E+ A      E     +E   E+ E + ++ E + E
Sbjct: 452 --KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509

Query: 197 ----RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
               R +E   + E +  + EEK  +      Q +++ EQ  +++    +M         
Sbjct: 510 QEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568

Query: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
           +  K+++  EK  ++ E +R+Q E+++E+        ++++EQ +     EE +    ++
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQ-------EEKIREQEEMTQEQEEKMGEQEEK 621

Query: 313 NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
               EEK++E  E    +    E   E ++  RE E ++REQ +M   +  +  ++ E  
Sbjct: 622 MCEQEEKMQEQEE---KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678

Query: 373 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
            E     Q+  +K R+    + +    L  Q+E   E Q+
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 48/225 (21%), Positives = 115/225 (51%), Gaps = 7/225 (3%)

Query: 81  KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
           ++EE +  Q  +R+ E++ E   + R E+K  ++E E+   Q E++ E + K+++Q+  +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK--IREQEEIWRQKEKIHEQEEKIRKQEEKM 559

Query: 139 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
            R+ ++   + ++  E +E+   +     +  E     +E   E+ E  Q++ E + E+ 
Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619

Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
           +++    E ++ + E+          Q K++ EQ  ++++    M++      ++  K+ 
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679

Query: 259 KLMEKKNQELEVVRQQRERLQEE---LSQAESTIDELKEQVDAAL 300
           +  EK  ++ E +R+Q E++ E+   L Q E  + E +E ++AA+
Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 58/275 (21%), Positives = 132/275 (48%), Gaps = 25/275 (9%)

Query: 82  EEEGLRAQV--RDLEEKLETLRLKRAEDKAKL-KELEKHKIQLEQVQEWKSKM--QEQQA 136
           E+E +R Q   R  EEK+     KR E +AK+ ++ EK + Q E+++E + KM  QE++ 
Sbjct: 449 EQEKIREQEEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507

Query: 137 DLQRRLKEARK---------------EAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
             Q +++E  K               E +E    KE+  E+        E     +E   
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567

Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
           ++ E ++++ E +  + +++    E ++ + E+       +  Q +++ EQ  ++ +   
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627

Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG 301
           +M++     +++  K+++  +K  ++ E +R+Q E +QE+  +     +++ EQ +    
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687

Query: 302 AEEMV----EMLTDRNLNLEEKVRELRETVGDLEA 332
            EE +    E + ++ + L ++  +++E    LEA
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 56/311 (18%), Positives = 136/311 (43%), Gaps = 27/311 (8%)

Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA----EERAESLQQEVEALKERV 198
           ++ +K + +  EA  R +E    T   +     + +MA    +   + L+ E   L  R+
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228

Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
            +       L+  +    +    +   +++L ++   L   L R        K+++ KLQ
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288

Query: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA-ALGAEEMVEMLTDRNLNLE 317
           + ++    E   ++   + L+ +L +A+  + + + Q +A  LG E            L+
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE------------LQ 336

Query: 318 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
               +L+  V + E  N +N + +E     E +++E  +    +++E ++++   +E + 
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEEKIR 392

Query: 378 DYQQTIKKYRQLTAHLQDVNR---ELTNQQEASVERQQQPPPETFDFKIKFAETKAH--A 432
           + ++ +++  ++    ++  R   E+  ++E  + RQ++   E  + KI+  E K H   
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQE 451

Query: 433 KAIEMELRQME 443
           K  E E ++ E
Sbjct: 452 KIREQEEKRQE 462



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 17/106 (16%), Positives = 58/106 (54%), Gaps = 6/106 (5%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
           K+ ++E  I+E ++ ++ + E   E   ++   E+K+   +   ++ +E++ + + ++ E
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645

Query: 867 TQALLRKKEKEFEETMDALQADIDQL---EAEKAELKQRLNSQSKR 909
            +  +R++E++  E  + +Q   +++   E +  E ++++  Q ++
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%)

Query: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 871
           ++R+ +  EL ++  I  EEL E N +L    + ++S   +    +++++ +LE  + LL
Sbjct: 261 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319

Query: 872 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 908
            +++ + E     + + ++ A + Q + E+ EL  RLN Q +
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 360



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 17/83 (20%), Positives = 49/83 (59%), Gaps = 3/83 (3%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
           K+ ++E  I+E ++ ++ + E + E   ++   E+K+   +   ++ +E++ + + ++ E
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701

Query: 867 TQALLRKKEKEFEETMDALQADI 889
            +  LR++E++ +E  + L+A I
Sbjct: 702 QEVRLRQQEEKMQEHQEHLEAAI 724



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 23/99 (23%), Positives = 50/99 (50%), Gaps = 1/99 (1%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
           K+ D+E  I+E ++ +  + E++ E   ++   E+K+    +   E+ EK+  + EE   
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ-EEKMC 623

Query: 870 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
              +K +E EE M   +  I + E +  E ++++  Q +
Sbjct: 624 EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662



 Score = 31.2 bits (69), Expect = 5.9
 Identities = 18/109 (16%), Positives = 58/109 (53%), Gaps = 6/109 (5%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
           K+ ++E  I++ ++ +  + E++ +   ++   E+K+   +   ++ +E+I + + ++ E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603

Query: 867 TQALLRKKEK---EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
            + + +++E+   E EE M   +  + + E +    ++++  Q K+  E
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 73/352 (20%), Positives = 180/352 (51%), Gaps = 28/352 (7%)

Query: 81  KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
           ++EE LR Q   +R+ EEK+     +  E + +L+E EK   + ++++E + +MQEQ+  
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356

Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
           +  + ++ R++ ++    +ER  E+     +  +     +E   E+ E L+++ E ++E+
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416

Query: 198 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
            +++   +E ++ E + +  +      + K  EE+  R ++  +R  + +  E++E ++ 
Sbjct: 417 -EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475

Query: 258 QK----LMEKKNQELEVVRQQRERL--QEELSQAESTIDELKEQV---------DAALGA 302
           Q+      E+K  + + + +Q+E+L  QE++ + E  I E +E++         +  +  
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535

Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDL-EAMNEMNDELQENARETELELREQLDMAGAR 361
           +E +    D+    EEK+R+  + + D  E M +   E ++   + E ++RE+      R
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-----ER 590

Query: 362 VREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
           +RE +K++   +E + + ++   K ++    +Q+   ++  Q+E   E++++
Sbjct: 591 MREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 88/392 (22%), Positives = 184/392 (46%), Gaps = 47/392 (11%)

Query: 76  LPSPSKEEEGLRAQVRDLEEKLETLRL--------------------KRAEDKAKLKELE 115
           LP    E+  ++  V++L+ KLE  +                      R ++K   K+ E
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293

Query: 116 KHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATL 175
           K   Q E+++E + KM+EQ+  + R+ K  R++ KE L  +E+ + E  +  +  E    
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELREQKELREQEEQMQE 352

Query: 176 DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR 235
            +E   E+ E ++++ E +  R +E   + E    E E+K  D      Q +++ EQ+ R
Sbjct: 353 QEEKMWEQEEKMREQEEKM-WRQEERLWEQEKQMREQEQKMRD------QEERMWEQDER 405

Query: 236 LKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
           L++   RMR+        EK    K  +  EKK ++ E   Q+ ER++E   +     + 
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465

Query: 292 LKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351
           ++EQ +     EE +    ++    ++++ E +E + + E M E  +++ E     E ++
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEKMQEQEEKIWEQ----EEKI 520

Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
           R+Q +M G      Q++    QE + + +  + +  +    ++D  +++ +Q+E   ++ 
Sbjct: 521 RDQEEMWG------QEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKMWDQEERMEKKT 571

Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
           Q+   +T+D + K  E +   +  E ++R+ E
Sbjct: 572 QEQEKKTWDQEEKMRE-EERMREREKKMREEE 602



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 86/402 (21%), Positives = 184/402 (45%), Gaps = 35/402 (8%)

Query: 81  KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
           ++E+ LR Q  +R+ EE+++    K  E + K++E E+ K+  ++ + W+ + Q ++ + 
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQ 390

Query: 139 QRRLKEARK-EAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA-----ESLQQEVE 192
           + R +E R  E  E L  KE  M E     + +E    +K+M E+       E   QE E
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450

Query: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
            ++ER  ++  + E ++ E EEK      + ++ ++ E Q  RL +   ++ +    ++Q
Sbjct: 451 RIREREKKMREEEETMR-EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509

Query: 253 EHV------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
           E        K++   E   QE ++ RQ++ R QE+  Q     +++++Q       EE +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED--QMWEQEEKMRDQEQKMWDQEERM 567

Query: 307 EMLT-----------------DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 349
           E  T                 +R    E+K+RE  E + + E   +  +E  +   E   
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627

Query: 350 ELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 409
           E  E++     ++ E ++++   +E + + Q+  ++  +L  H +   +E   +QE  + 
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687

Query: 410 RQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 451
            Q++   +T + + K  + +   +   M  R+ ++ +    M
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 75/388 (19%), Positives = 179/388 (46%), Gaps = 25/388 (6%)

Query: 81  KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
           +EE+ ++ Q    RD EEK++     R  +K   +E E  + Q E++Q+ +  M EQ+  
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486

Query: 138 --LQRRLKEARK---EAKEALEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEV 191
              Q+RL E ++   E ++  E +E+  E+     D  EM   +K+M  +E+    + ++
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546

Query: 192 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEK 251
              +E++ +    +   +  +E+K  +    ++  ++   +  R+++   +MR+     +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606

Query: 252 QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE---- 307
           ++  K+Q+  EK  ++ E + +Q E++QE+  +     +++ EQ +     + + E    
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666

Query: 308 MLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ------------ENARETELELREQL 355
           +     +  +EK++E  E + + E M +   E +            E+ RE E ++RE+ 
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726

Query: 356 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
           +M   +  + Q++ E  QE   +  +  +K  +    + +  R    +++     + Q  
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786

Query: 416 PETFDFKIKFAETKAHAKAIEMELRQME 443
            + ++ + K  + +   +  E ++R  E
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQE 814



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 68/320 (21%), Positives = 155/320 (48%), Gaps = 20/320 (6%)

Query: 82  EEEGLRAQVRDLEEKLETLRLKRAE--DKAKLKELEKHKIQLEQVQEWKSKMQEQQA--- 136
           E+E ++ Q   + E+ E +R +      + K+   EK + Q +Q+ E + KM++Q+    
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561

Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
           D + R+++  +E ++    +E  M E     +  +    ++EM  E+ E +Q++ E ++E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621

Query: 197 RVDELTTDLEILKA------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250
           + +++    E ++       E EEK  +     ++ ++L EQ  +L +           E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681

Query: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE------STIDELKEQVDAALGAEE 304
           ++E +  Q+ MEKK QE E     +E+++EE S  E         + ++EQ +     EE
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741

Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
            ++   +     EEK+ E  E + + + + E  ++L E+ +  E   +E++     ++R+
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE---QEKIWEQEEKMRD 798

Query: 365 AQKRVEAAQETVADYQQTIK 384
            ++++   +E +   ++ ++
Sbjct: 799 QEEKMRGQEEKMRGQEEKMR 818



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 76/337 (22%), Positives = 154/337 (45%), Gaps = 36/337 (10%)

Query: 92  DLEEKLETLRLKRAEDKAKLKELEKHK----IQLEQVQEWKSKMQEQQADLQRRLKEARK 147
           +L+  L  +  +  +    ++EL K +    ++L +      +++++ A+LQ +L  A  
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239

Query: 148 EAKEA-LEAKE--RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE-----RVD 199
           E  E  L  KE  R +E        ++  TL +EM  +  E  +QE +  K+     R +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299

Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
           E   + E    E EEK         Q K+L EQ   L++    +R+     +QE  ++Q+
Sbjct: 300 ERLREQEGKMREQEEK------MWRQEKRLREQEKELREQEKELREQKELREQEE-QMQE 352

Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
             EK  ++ E +R+Q E++  +  +      +++EQ       EE +    +R    EE+
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412

Query: 320 VRELRETVGDLEAMNEMN--DELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
           +RE  +    +E M E     E ++  R+ E +++E+      R+RE +K++   +ET+ 
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-----ERIREREKKMREEEETMR 467

Query: 378 DYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQP 414
           + ++ ++K  +           +  Q+E   ++Q+ P
Sbjct: 468 EQEEKMQKQEE----------NMWEQEEKEWQQQRLP 494



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 64/281 (22%), Positives = 139/281 (49%), Gaps = 28/281 (9%)

Query: 81  KEEEGLRAQVRDLEEKLETL--RLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
           ++EE ++ Q   + E+ E +  + ++  ++ +L E ++   + E++QE + KMQEQ+  +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE-QEKMQEQEEKI 686

Query: 139 --QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
             Q ++++  +E ++    +E+  EE +      +M   ++EM  E+ E +Q++ E ++E
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE-EEEMMREQEEKMQEQEEKMQE 745

Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 256
           + +E+         E EEK  +     ++ ++L EQ  +L +           + QE  K
Sbjct: 746 QEEEMW--------EQEEKMWEQEEKMWEQQRLPEQKEKLWE---------HEKMQEQEK 788

Query: 257 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 316
           + +  EK   + E +R Q E+++ +  +     +++  Q +   G EE +    ++    
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848

Query: 317 EEKVRELRETVGDLEAMNEMNDEL---QENARETELELREQ 354
           EEK+ E  +  G  E M E  +++   +E  RE E ++R Q
Sbjct: 849 EEKMEEKMQ--GQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 5/102 (4%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
           K+ ++E  ++E ++ +  + E L E   ++   E+K+    +D +ER+ +   RL E + 
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM----RDQEERMWEQDERLREKEE 411

Query: 870 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTI 911
            +R++EK +E+ ++ ++ +    E EK    Q    Q +  I
Sbjct: 412 RMREQEKMWEQ-VEKMREEKKMQEQEKKTRDQEEKMQEEERI 452



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 22/103 (21%), Positives = 54/103 (52%), Gaps = 4/103 (3%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV---QTRLEE 866
           K+ + E++ +E +K ++ + E + E   ++   E+K+    ++  E+ EK+   + ++ E
Sbjct: 708 KMREEESM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766

Query: 867 TQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
            Q L  +KEK +E      Q  I + E +  + ++++  Q ++
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809



 Score = 31.6 bits (70), Expect = 4.5
 Identities = 23/114 (20%), Positives = 56/114 (49%), Gaps = 13/114 (11%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV--------- 860
           ++ +RE  ++E ++ ++ + E++ E   ++   E+K+    +   E+ EK+         
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649

Query: 861 -QTRLEETQALLRKKEKEFEETMDALQADIDQLEA---EKAELKQRLNSQSKRT 910
            + ++ E Q L  +KEK +E      Q  + + E    E+ +++++   Q K+T
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703



 Score = 30.8 bits (68), Expect = 7.7
 Identities = 23/112 (20%), Positives = 49/112 (43%), Gaps = 9/112 (8%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
           K+ D+E  + E  + L+ K E + E       +EK  +       E+  + Q    + + 
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450

Query: 870 LLRKKEKEFEETMDALQADIDQL---------EAEKAELKQRLNSQSKRTIE 912
            +R++EK+  E  + ++   +++         + EK   +QRL  Q ++  E
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 199/973 (20%), Positives = 384/973 (39%), Gaps = 169/973 (17%)

Query: 76   LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
            L    KE+     +V++L E++    ET+     E KA        L +L+  + ++  +
Sbjct: 965  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024

Query: 125  QEWKSKMQEQQADLQRRLKEARK------EAKEALE-----AKERYMEEMADTADA---- 169
             + K K+++Q  DL+  L++ +K       AK  LE     A+E  M+   D        
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084

Query: 170  ----IEMATLDKEMAEERA--ESLQQEVEALKERVDELTTDLEI---LKAEIEEKGSD-- 218
                 EM+ L  ++ +E+A    LQ++++ L+ R++EL  ++E     +A+ E++ SD  
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144

Query: 219  -------------GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK- 264
                         G A+S Q++  +++ A  +      RDL  +  Q       L +K  
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKHA 1201

Query: 265  ------NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNL 314
                   ++++ +++ +++L++E S+ +  ID+L   ++    A    E+M   L D+  
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261

Query: 315  NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 374
             ++ K  E +  + DL A       LQ  + E   +L E+  +     R  Q   +  +E
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRA---RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318

Query: 375  TVADYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIK 424
                 ++ IK    L   LQ        +  +   +QEA  E Q+   +   E   ++ K
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378

Query: 425  FAETKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLL 477
            + ET A  +  E+E  + ++AQ    A  H+  + A    +  +  R   + + +++ + 
Sbjct: 1379 Y-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437

Query: 478  MPRLICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLL 529
                 C A   +++  +K   E  + C E    L  +  E  S +  L      Y  SL 
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497

Query: 530  QA-TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLD 578
            Q  TL R    L Q   D+ +++            +  ++   +  L   +E        
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557

Query: 579  ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------R 632
            E   +  +   +   +      +AE+ E+      +HI+  +S    +  E+       R
Sbjct: 1558 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617

Query: 633  LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDT 692
            L+  ++G          L ++E   +   +   +  R    T A      L     + D 
Sbjct: 1618 LKKKMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL----HLDDA 1664

Query: 693  LL---DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
            L    D ++ L  V      + A   +L A L + E     A +EL   ASE++      
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV------ 1717

Query: 750  SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
               + L      LI+T  KL T + + + + E    +    E +A   +  ITDA  +  
Sbjct: 1718 ---QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAAMMAE 1771

Query: 810  KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIE 858
            +L+  +     L++  K   + + +   RL   E+           KL++  ++ +  +E
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831

Query: 859  KVQTRLEETQALLRKKEKEFEE-----------------TMDALQADID--QLEAEKAEL 899
              Q R  E    LRK E++ +E                  +D LQA +   + +AE+AE 
Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891

Query: 900  KQRLNSQSKRTIE 912
            +  +N    R I+
Sbjct: 1892 QSNVNLSKFRRIQ 1904



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 174/877 (19%), Positives = 353/877 (40%), Gaps = 107/877 (12%)

Query: 74   PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ----VQEWKS 129
            P L S   E+E     + +++E+ E  + + A+ +AK KELE+  + L Q    +Q    
Sbjct: 842  PLLKSAETEKE-----MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896

Query: 130  KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
               +  AD + R  +  K  K  LEAK + + E A+  + I      K+        L+ 
Sbjct: 897  AEADSLADAEERCDQLIK-TKIQLEAKIKEVTERAEDEEEINAELTAKK------RKLED 949

Query: 190  EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
            E   LK+ +D    DLE+  A++E+   +  A+  ++K L E+ A L + + ++    + 
Sbjct: 950  ECSELKKDID----DLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TK 998

Query: 250  EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
            EK      + L E   Q L+ ++ + +++   L++A+  +++  + ++ +L  E+ + M 
Sbjct: 999  EK------KALQEAHQQTLDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKIRMD 1051

Query: 310  TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
             +R    LE  ++  +E+  D+E   +  DE  +        L+ +++   A   + QK+
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKK 1111

Query: 369  VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
            ++  Q  + + ++ I+  R   A  +    +L+ + E   ER ++    T     +    
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMN 1168

Query: 429  KAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 486
            K      +   R +E A  Q     + L     DS    G   D +  +        K +
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQK 1220

Query: 487  LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 546
            L +++++ K E+ +  S    +  A G        L   LS ++      +  ++    D
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN----D 1276

Query: 547  VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 606
            +  +   L  E   + R LD       KD L     V  L++  + +         +Q E
Sbjct: 1277 LTAQRARLQTESGEYSRQLD------EKDTL-----VSQLSRGKQAF--------TQQIE 1317

Query: 607  DCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF 663
            +   QL + IK   +   AL     +   LR   +  QEA   A L R +  + S++ Q+
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK--AELQRAMSKANSEVAQW 1375

Query: 664  CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
              K       TDA           Q ++ L + +K L   +   +E   A     A L +
Sbjct: 1376 RTKYE-----TDA----------IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERP 783
             +  L   +E+L                 E    +C  L          + E +   E  
Sbjct: 1421 TKQRLQNEVEDLMIDV-------------ERTNAACAALDKKQRNFDKILAEWKQKCEET 1467

Query: 784  PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE 843
             ++    +  + +L  E+   +    +  D+   +K   K+L+ +  +L+E         
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527

Query: 844  KKLDSAAKDADERIEKVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELK 900
             +L+   K  ++   ++Q  LEE +A L  +E +    +  ++ +++++D+  AEK E  
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1587

Query: 901  QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 937
             ++     R +E ++    + I +    I  +++  G
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 52/278 (18%), Positives = 129/278 (46%), Gaps = 13/278 (4%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
            ++ LR+Q  DL+E+L  +  +    +A+++EL   +  LEQ +  +   +++  D   R+
Sbjct: 1662 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1717

Query: 143  KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV---D 199
            +    +    +  K++   +++     +E    +   AEE+A+    +   + E +    
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777

Query: 200  ELTTDLEILKAEIEEKGSD-----GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEH 254
            + +  LE +K  +E+   D       A    LK  ++Q  +L+  +  +     SE++ +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837

Query: 255  VKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNL 314
            V+  K + K  ++++ +  Q E  ++ + + +  +D+L+ +V +     E  E  ++ NL
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897

Query: 315  NLEEKVR-ELRETVGDLEAMNEMNDELQENARETELEL 351
            +   +++ EL E     +      ++L+  +RE   ++
Sbjct: 1898 SKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 54/257 (21%), Positives = 115/257 (44%), Gaps = 40/257 (15%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
            + +E L+ Q+  +E +   L+ +  E +A L++ E+              ++QL   Q  
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725

Query: 128  -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
                 K K++   + +Q  +++  +EA+ A E  ++ + + A  A+ ++         E 
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785

Query: 183  RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEE-QNAR 235
              ++L+Q V+ L+ R+DE           +I K E   +  +G   S Q + +E  +  R
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845

Query: 236  LKDALVRMRDLSSSEKQEHV-KLQKLMEKKNQELEVVRQQRE--------------RLQE 280
              +  V+     + E ++++ +LQ L++K   +++  ++Q E              R+Q 
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905

Query: 281  ELSQAESTIDELKEQVD 297
            EL +AE   D  + QV+
Sbjct: 1906 ELEEAEERADIAESQVN 1922


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2207 EELQRLKAEATEAAR 2221



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 973  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1781

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1902 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1945

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2002

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 2003 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2052

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2053 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2093

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2211

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2212 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2269

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2270 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2298

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2352

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2353 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ 2484



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1667

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1966

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2025

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2083

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2084 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2187

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2245

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2303

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2360

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2361 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2479 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2522



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2257

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2498 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2302 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2417

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2473

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2474 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2523

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2524 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2579

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1571

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1627

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1803

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1846

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1892

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1947

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1948 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1980

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1981 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2034

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2210

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2211 EELQRLKAEATEAAR 2225



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1479

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1480 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1529

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1581

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1582 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1634

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1684

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1723

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1724 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1776

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1837 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1937

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1938 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2048

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2049 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2099

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2100 ARVQAEREAAQSRRQVE 2116



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1057 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1116

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1117 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1232

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1406

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1467 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1580

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1757 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1874

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1930

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2461

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2462 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2566

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2623

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2680

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2727



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 977  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1031

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1152 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1269 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1322

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1323 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1434

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1435 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1476

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1651

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1766

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1827 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1878

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2207 EELQRLKAEATEAAR 2221



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 973  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1745

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1866 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1909

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1966

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 1967 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2016

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2017 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2057

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2175

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2176 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2233

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2234 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2262

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2316

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2317 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ 2448



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1631

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1930

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1989

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2047

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2048 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2151

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2209

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2267

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2324

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2325 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2443 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2486



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2221

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2462 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2266 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2381

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2437

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2438 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2487

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2488 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2543

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1535

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1591

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1767

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1810

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1856

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1911

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1912 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1944

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1945 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 1998

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2174

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2175 EELQRLKAEATEAAR 2189



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1443

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1444 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1493

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1545

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1546 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1598

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1648

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1687

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1688 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1740

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1801 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1901

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1902 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2012

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2013 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2063

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2064 ARVQAEREAAQSRRQVE 2080



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1021 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1080

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1081 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1196

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1370

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1431 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1544

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1721 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1838

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1894

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2425

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2426 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2530

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2587

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2644

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2691



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 941  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 995

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 996  KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1116 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1233 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1286

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1287 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1398

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1399 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1440

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1615

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1730

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1791 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1842

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1914

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 2035 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 2078

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2135

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 2136 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2185

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2186 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2226

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2344

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2345 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2402

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2403 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2431

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2485

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2486 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ 2617



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1800

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 2099

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2158

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2216

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2217 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2320

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2378

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2436

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2493

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2494 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2612 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2655



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2390

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2631 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2435 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2550

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2606

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2607 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2656

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2657 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2712

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1704

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1760

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1936

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1979

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 2025

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 2080

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 2081 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2113

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 2114 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2167

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2343

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2344 EELQRLKAEATEAAR 2358



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1612

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1613 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1662

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1714

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1715 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1767

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1817

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1856

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1857 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1909

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1970 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 2070

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 2071 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2181

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2182 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2232

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2233 ARVQAEREAAQSRRQVE 2249



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1190 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1250 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1365

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1539

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1600 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1713

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1890 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 2007

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 2063

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2594

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2595 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2699

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2756

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2813

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2860



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 1110 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1164

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1285 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1402 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1455

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1456 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1567

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1568 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1609

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1784

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1899

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1960 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 2011

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1755

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1876 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1919

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1976

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 1977 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2026

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2027 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2067

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2185

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2186 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2243

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2244 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2272

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2326

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2327 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQ 2458



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1641

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1940

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1999

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2057

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2058 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2161

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2219

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2277

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2334

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2335 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2453 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2496



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2053

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2231

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2472 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2276 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2334

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2391

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2447

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2448 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2497

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2498 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2553

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1545

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1601

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1777

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1820

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1866

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1921

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1922 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1954

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1955 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2008

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2128

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2184

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2185 EELQRLKAEATEAAR 2199



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1453

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1454 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1503

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1555

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1556 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1608

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1658

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1697

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1698 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1750

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1811 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1911

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1912 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1965

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2022

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2023 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2073

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2074 ARVQAEREAAQSRRQVE 2090



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1031 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1090

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1091 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1206

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1380

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1441 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1497

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1498 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1554

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1731 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1848

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1904

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2435

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2436 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2540

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2597

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2654

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2701



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 951  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1005

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1006 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1065

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1126 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1243 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1296

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1297 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1408

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1409 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1450

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1625

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1740

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1801 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1852

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1763

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1884 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1927

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1984

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 1985 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2034

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2035 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2075

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2193

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2194 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2251

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2252 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2280

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2334

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2335 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQ 2466



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1649

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1948

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2007

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2065

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2066 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2169

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2227

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2285

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2342

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2343 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2461 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2504



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2061

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2239

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2240 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2299

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2480 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2284 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2342

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2399

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2455

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2456 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2505

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2506 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2561

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1553

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1609

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1785

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1828

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1874

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1875 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1929

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1930 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1962

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 1963 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2016

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2136

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2192

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2193 EELQRLKAEATEAAR 2207



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1461

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1462 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1511

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1563

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1564 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1616

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1617 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1666

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1705

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1706 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1758

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1819 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1919

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1920 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1973

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2030

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2031 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2081

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2082 ARVQAEREAAQSRRQVE 2098



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1039 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1098

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1099 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1157

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1214

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1388

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1449 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1505

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1506 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1562

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1739 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1856

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1912

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2443

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2444 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2548

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2605

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2662

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2663 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2709



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 959  EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1013

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1014 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1073

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1134 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1251 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1304

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1305 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1416

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1417 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1458

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1633

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1748

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1809 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1860

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)

Query: 82   EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            E E    Q + LEE+L  L+ + A    K +ELE    +L +V+     +   +A  +  
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1804

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
             +   +++K+ LEA+     E+A+ A  +    E A   +++AEE A   + E E  L E
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864

Query: 197  RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
            ++        L T+ EI     +AE E         ++Q ++LEEQ A+    +++ L +
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924

Query: 243  MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
            +R  S SE          +E++   +E   +QR +++EE+   +++ ++      AA G 
Sbjct: 1925 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1968

Query: 303  EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
             E+   L     N E+ +R   +   +LEA  +     +E  R  E E R Q  +A    
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2025

Query: 363  REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
             EA ++ +AA E V   +  +++ R+L     Q+  R+L   QEA+ +R Q         
Sbjct: 2026 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2075

Query: 422  KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
                AE KAHA A++ + ++++     +  S+L            G+ +         R 
Sbjct: 2076 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2116

Query: 482  ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
              +AE  R QA+ E  +      E   L+ +A EQ    A    +   L+    +     
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176

Query: 541  SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
            +Q      ++  +   EM  H++  +  +    K Q+++ +    L  +   + ++L   
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2234

Query: 600  HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
             L     + T + A      +  L  + V++  L   L+   EA + AL+LRD + +   
Sbjct: 2235 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2292

Query: 660  IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
            +++  +K++                   QV++             A    VAA  A  + 
Sbjct: 2293 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2321

Query: 720  PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
             LAE +     AL E   K   Q     T   +  E L+Q   +      + A  +QE  
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2375

Query: 778  YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
             D E+            A   AE T      L+ E  R+  +    + LK++  E+S A 
Sbjct: 2376 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
             R     ++    A++  E++ + +   +E   L++  E   ++ +   + L+  I +LE
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483

Query: 894  AEKAELKQ-----RLNSQSKRTIE 912
             EK +L+Q     +L S+  +T++
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQ 2507



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)

Query: 81   KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
            +EE   RAQ + + E   E    +    + K  E  + ++Q E+V + KS  Q   A+ +
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1690

Query: 140  RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
            ++ +EA +EA+   +A+E+ +                            +E+       E
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750

Query: 172  MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
                 +++ EE    LQ+E  A  ++  EL  +L  ++AE+           EE  S   
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810

Query: 221  ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
             S  +L       ++L E+ ARL+   +   R R L+  +      + E V  +KL    
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870

Query: 261  ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
                        +++K  E E +R+       QR RL+E+ +Q ++ I+E   Q+  A  
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 302  AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
            +E      +VE    +   +EE++  L+ +      G  E   E+   ++ NA +T    
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1989

Query: 348  ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
               ELE   Q  +A     R REA++RV+    A +E     +  +++  +L A +++  
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2048

Query: 398  RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
            R L  + E    RQ Q   E    +++ AE KAHA A++ + ++++     +  S+L   
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2106

Query: 458  MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
                     G+ +         R   +AE  R QA+ E  +      E   L+ +A EQ 
Sbjct: 2107 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152

Query: 517  SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
               A    +   L+    +     +Q      ++  +   EM  H++  +    L  K Q
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2210

Query: 577  LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
            +++ +    L  +   + ++L    L     + T + A      +  L  + V++  L +
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2268

Query: 636  FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
             L+   EA + AL+LRD + +   +++  +K+++     +A  +  A     ++      
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2326

Query: 695  DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
            D  +       +L+E   A  +     AE E  L+   +ELA + + ++         + 
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2383

Query: 755  LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
            L +       T+   A   ++ E  AE    K    E+  A  RAE         AE +G
Sbjct: 2384 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441

Query: 809  LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
             KL   E   +E   L ++L+I+        E L EA   L   ++KL   AK    + E
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501

Query: 859  KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
            ++QT      L+ETQAL    ++ F    D+L      +E EKA+L+Q
Sbjct: 2502 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2545



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)

Query: 80   SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
            +K EE  R + R  +E    L+L +   + +L+  EK H   ++Q  QE +  +Q++Q+ 
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102

Query: 137  --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
               L+   + AR+ A+EA EA+ +   E A +   +E A   K+ AEE+A++  Q   A 
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162

Query: 195  ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
                KE   E     +  +A + +K +  A      K  E+   Q A+++  L  +R  L
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222

Query: 247  SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
              ++ Q+++  ++L   K +  E  R QR +++EEL      ++EL  ++ A + AE   
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2280

Query: 307  EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
             +L D++     L+E+  ++++   +   ++    E     +  E +L +Q  +A   ++
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340

Query: 364  EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
            E  + V+ A    A+    QQ  +  ++    LQ+   ++  Q            EA  +
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 410  RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
            RQ +   E    K++ AE ++A A+A E   R   Q E      H + L      T    
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
                R   DHD   +   +  L  + E ++++A   Q K E  +   +   L+     Q 
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520

Query: 517  SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
            SF   L    SLLQ    + + +  L Q   D   K   L  E    ++ ++
Sbjct: 2521 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)

Query: 83   EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
            EE L AQ R L EK+   +++  ++  +LK E E  + Q E  QE   ++QE +  + ++
Sbjct: 2325 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
            L E  +  +  LEA+ +   EM+  A+ +++   +   A+ RAE   ++ +  +++ +E+
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2440

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
               L   +   +EK +       Q +Q +    RL++A+  +      EK++  +  KL+
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2496

Query: 262  EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
            + K++E++ V QQ + LQE  +  +S + E     D+ L  E  +E        LE+   
Sbjct: 2497 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2546

Query: 322  ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
              ++ V   + + E     Q+   +    L   ++ A  R  EA++ V   QE   + QQ
Sbjct: 2547 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2602

Query: 382  TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
              ++ RQ    L + N+ L  Q +   E+ +
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)

Query: 86   LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
            +  ++R +  +LE    +R   + +L+ L    E+ + Q  Q QE   +++ Q  D  +R
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 142  LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
             ++A  E    ++A+     E      A+E   L  E AE R    Q EVE  ++    L
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1594

Query: 202  TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
             T     +AE++ K +  A  + QL++ L+E++     A+ ++R+ +    Q+  + ++ 
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1650

Query: 261  MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
             E+  +ELE           +R Q E + ++ S A++  ++ KE+ +         E   
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710

Query: 311  DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
             R   L E+  E +  + +  A   +    EL     ETE   + R+ L+   AR+ REA
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770

Query: 366  QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
                +  QE  A+  +   +   L A       E  +  E S +R +    E   F+ + 
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1826

Query: 426  AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
            AE  A  +A+  E  RQ ++A+             +   R   + + VL      +L   
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1869

Query: 485  AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
             E  R + + +  L E  +E   LR  A ++                   R E   +Q  
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1915

Query: 545  VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
             D+ +++  L     +       L+E    D L +   VE    A+K      +   AE 
Sbjct: 1916 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1970

Query: 605  PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
                                 + +E+GR+R+       A D        E   +  RQ  
Sbjct: 1971 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2003

Query: 665  KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
             +  RR    +   +  +LA   + +       + +  + A ++E     A+ +   AE 
Sbjct: 2004 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2057

Query: 725  EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
            E      L + A     +A E+ +        + L+Q+     S +++L    +     A
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117

Query: 781  ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
            E         E  AA  R ++ +AE L    E++     + + + +   +E  +   R +
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2177

Query: 841  LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
              E+      + AD  +EK +   E+T   LR+K  + E+ +  L+  +++ + +K  L 
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2233

Query: 901  QRLNSQSKRTIEGLR 915
            + L        E  R
Sbjct: 2234 EELQRLKAEATEAAR 2248



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)

Query: 87   RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
            R ++ ++E  LE  R L  A  +AK +   + K   +++QE   + +E   D Q++ +  
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445

Query: 146  RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
            ++E ++  ++ E  ++  A  A+A E + L     EE    ++ ++EA + +      +L
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1502

Query: 206  EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
            + L+A  EE       +  Q +Q +E+  RL+    +++D S  ++Q  V+L        
Sbjct: 1503 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1552

Query: 258  QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
            +   EK+   Q LE +R Q E  +  L QAE    E   QV  AL   +           
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1604

Query: 316  LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            L+ K     E    LE        LQE       +LRE+ +    +  EA++  E A+  
Sbjct: 1605 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1657

Query: 376  VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
            +  +Q    +  +L    ++V ++ +  Q A  E+Q++             E +   KA 
Sbjct: 1658 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1707

Query: 436  EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
            E  +RQ E+A    +  R ++  TA                       RL  + ELIR +
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1746

Query: 492  AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
            A    E  +   +R  L          AA        L+A L +     ++  V +  K 
Sbjct: 1747 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1799

Query: 552  GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
             +     S  E+S   L       ++  +E   +  L +  K  + L     A Q  +  
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859

Query: 610  MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
              LA+                 +L A  +  +  T+  + L++ E     +R+  +    
Sbjct: 1860 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902

Query: 667  IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
             RRR+    A     I   LA   + SD+ L+ +K L  V   L++      +++A  A 
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1960

Query: 724  NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
             E       E       E   G   S+  + LR  +   +  +   +LA   +    +AE
Sbjct: 1961 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2014

Query: 782  RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
                K    E  AA  R A + + E L  K+E+    RE   +E  + L++  E    A 
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2071

Query: 837  VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
             RL   EK   + A    ++ +++Q  L++ Q++L +   E E    A +      EAE+
Sbjct: 2072 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2122

Query: 897  AELK-QRLNSQSKRTIE 912
            A ++ +R  +QS+R +E
Sbjct: 2123 ARVQAEREAAQSRRQVE 2139



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)

Query: 76   LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
            LP PS     LR+          QVR L     EKL+T+ L     +   + L  H+ QL
Sbjct: 1080 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1139

Query: 122  EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
            ++ Q   + + E +A  +  LK+ R +A+      +   +E+    +  E         +
Sbjct: 1140 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198

Query: 182  ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
               E  ++ V  L ER   +    ++ + E+E+ G       Y  +  +   A L+DA  
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1255

Query: 242  RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
            R   + +    +   +++ + ++   LE + +  E+++E    A+  I+ +K+       
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315

Query: 295  -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
                         +     G+E +++   D   +  E      + +  +       +E +
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375

Query: 342  ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
              A +   E RE+L    A + + ++  EA  +  A  ++  K+ +      Q +  E+ 
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1429

Query: 402  NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
             ++EA+V+ QQQ     E      + +E +  AKA + E  +    +    + ++   + 
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489

Query: 460  DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
             +  + GG    +  L        +AE  ++QAQE+ E      +    R          
Sbjct: 1490 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1546

Query: 510  --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
               A  E        + +L  L+      E  L Q  V+  ++V      +   +RS + 
Sbjct: 1547 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1603

Query: 568  LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
             ++       ++T  +E   +     +H+    L E+ E    Q A+  +  + A   L+
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 625  CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
               ++    LR  LQ  + A   +L   + E    +                       Q
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 663  FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
              +K R+   GT    + A        ++T      R+ L   +A LQ  AAAA Q    
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779

Query: 717  LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
            L A LA+    +   L   A +A E+   T   S          +  L +    L +   
Sbjct: 1780 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838

Query: 768  KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
            +     Q  E DA R  ++   V     A   E     T+AE + LK ++ E   ++ L 
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1897

Query: 823  KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
            +    +   L E A    + +E++L    K +D  +E+ +  +E+T     ++ ++ EE 
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1953

Query: 882  MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
            + AL+A  ++  A KAEL+  L        + LR    + + A     +A EE++R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)

Query: 81   KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
            ++ +  R Q  ++ EKL    L   E    ++ LE   IQ +Q      +++E  A+L+R
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2484

Query: 141  RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
              ++ ++EAK  L+ K              EM T+ +E   +  ++LQQ   + K+ + +
Sbjct: 2485 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531

Query: 201  LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
                +E  KA++E+   D  A + QL++ E+Q  + +    R R ++S E   +++H + 
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2589

Query: 258  QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
            ++ + +K +EL+ + QQR    E L EE  +    +  L+EQ  AAL   E V   T   
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2646

Query: 314  LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
            +   + +   R+ +    A  E         R+      ++L  AG    E  +R+    
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2703

Query: 374  ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
             TV +   ++ ++ Y Q  + +  +  + TN++    A+++RQ   P
Sbjct: 2704 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2750



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)

Query: 133  EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
            EQ A  + R +    E K+      R   E  +T     +   LDKE A E A+ +    
Sbjct: 1000 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1054

Query: 188  --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
              Q EVE L + V  L+ + E + A  E   +     S       +L+Q+   +A    +
Sbjct: 1055 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1114

Query: 236  LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
            LK   + +R    +E+     +E +K  + +     ELE  +   ++L+ +    + T D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174

Query: 291  ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
             L++++    GA+E+ E L  R+   + +V   RE V  L    +A+    D  Q    +
Sbjct: 1175 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 347  TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
               +L   RE  D  GA +++A++R E  Q   +AD Q   ++ RQ  A L+++ R    
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291

Query: 403  QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
             +E      +Q      D++++    KA  + +    ++ +V   +   S++  ++    
Sbjct: 1292 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1345

Query: 463  LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
            LR    H   L  L    +   +E +R+  +E+    +  +E           L     L
Sbjct: 1346 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402

Query: 523  VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
              + +  +A   R    L Q   +   +      +    +RS+   ++     QL ++  
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1457

Query: 583  VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
             E   KA            AE  E   +++ + I+  +  L+    +        +GG E
Sbjct: 1458 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1499

Query: 643  ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
                AL  R  + E      ++  +++RR++         A +    +V   ++   + +
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559

Query: 698  KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
            + L  +  +  +   A  +L     E    +  ALE     A  ++    +S     +  
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619

Query: 753  ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
            E   Q  ++ ++ + + A    + + +AER   +    EL    L+A     E L L+L+
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1674

Query: 813  DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
              E    K L ++   K +E +E    R    E++     + A++ +EK         Q 
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734

Query: 863  RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
            RL   Q L  LR + ++ E+    L+ ++ +L+ E A       +Q ++ +E       +
Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1789

Query: 921  GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
             +  L++  A  E++  +   ++   +         + +    L+ ++       QL  E
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849

Query: 977  NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
            ++  + A+ +  LA        KL+  G  + L   A    ++     E L +L+     
Sbjct: 1850 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1901

Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
                R    A    A + E++AQL+  SD+  + +  ++++T+ QR
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 81/405 (20%), Positives = 188/405 (46%), Gaps = 41/405 (10%)

Query: 82  EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 139
           E + L  +++ +  KL+  +++  E   +L + ++ K+  Q E++QEW+ K+QEQ+  + 
Sbjct: 266 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 323

Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
           R  +E  +E +E +  +E  M E  +     E    +KE    R E +  E E     ++
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383

Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
           E   + E ++ + E++  +      + +Q  EQ A++     ++R+     +++  K+ +
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQ--EQEAKMWRQEEKIREQEEKIREQEKKMWR 441

Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE-----------------------QV 296
             EK +++ ++  +++ + QEE+ + E  I E +E                       Q 
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE 501

Query: 297 DAALGAEEMVEMLTDRNLNLEEKVRE----LRETVGDLEAMNEMNDELQENARETELELR 352
           +     EE +    ++    EEK+RE    +RE    +    EM  E +E   E E +++
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561

Query: 353 EQLDM--AGARVREAQKRVEAAQETVADYQQTI----KKYRQLTAHLQDVNRELTNQQEA 406
           EQ  M     ++RE ++++   +E + + ++ I    +K R+    +Q+   ++  Q+E 
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621

Query: 407 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 451
             E++++   +  + K++  E K   + + +  ++ ++ +   H+
Sbjct: 622 MCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 88/414 (21%), Positives = 187/414 (45%), Gaps = 49/414 (11%)

Query: 68  TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 127
           TS G   P        +   A  R+LE ++ T+R+   + K +L+      + L   Q  
Sbjct: 100 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 152

Query: 128 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 173
             +++ +  DL  RL ++ K   E ++AL A        +RY+EE+    DA+ +     
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212

Query: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 217
           T+  E  +E+   LQ++++ ++    E+  +++ LK                AE +  G 
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 272

Query: 218 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 272
           +  + S +L+   E+N  L + L + ++     ++E +     K+Q+  EK  ++ E +R
Sbjct: 273 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331

Query: 273 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
           +Q E+++ +        ++++ Q +     EE +  L +     EEK+REL E + + E 
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK 391

Query: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
           + E  ++ QE  +  E E R++ +   A++   ++++   +E + + ++ + +  +    
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448

Query: 393 LQDVNRELTNQQEASVERQQQ---PPPETFDFKIKFAETKAHAKAIEMELRQME 443
            + +  E   Q++  + RQ++      E +  K K  E +   K  E   RQ E
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 76/303 (25%), Positives = 154/303 (50%), Gaps = 32/303 (10%)

Query: 89  QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 136
           ++R+LEEK+ E  +++  E+K     K++E EK + Q        E+++E + K++EQ+ 
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437

Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 193
            + R+ ++  ++ K   E K +  EEM    + I   E     KE   E+ +  +QE + 
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497

Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
            ++  +E   D E    E EEK         Q +++ EQ  ++++   ++R+     +++
Sbjct: 498 WRQ--EEKMHDQEEKIREQEEK------MWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549

Query: 254 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
             K+ +  E+K QE E +R+Q E+++E+  +     ++++EQ +     EE +    +  
Sbjct: 550 EEKMGE-QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608

Query: 314 LNLEEKVRELRETVGDL-EAMNEMNDEL---QENARETELELREQLDMAGARVREAQKRV 369
              EEK+ E  E + +  E M E  +++   +E   E E+ LR+Q +    +++E Q+ +
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHL 664

Query: 370 EAA 372
           EAA
Sbjct: 665 EAA 667



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 71/337 (21%), Positives = 153/337 (45%), Gaps = 25/337 (7%)

Query: 81  KEEEGLRAQVR---DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
           ++EE +R Q     + EEK+  L     E + K++ELE+   + E+++E + K QE++  
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405

Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDK--EMAEERAESLQQEVEALK 195
            ++  ++ ++      E K R  EE     +       +K  E  + R E  +QE E + 
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 465

Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
            + +++    EI + +            ++ +++ +Q  ++     +M D     +++  
Sbjct: 466 RQEEKIREQEEIWRQK---------EKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516

Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
           K+ +  EK  ++ E +R+Q E+++E+        +E+ ++ +  +G +E      ++   
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQ--------EEMMQEQEEKMGEQEEKMQEQEKMRR 568

Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
            EEK+RE  E + +     E   E +E   E E ++REQ +M   +  +  ++ E   E 
Sbjct: 569 QEEKIREQEEKIRE---QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625

Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
               Q+  +K R+    + +    L  Q+E   E Q+
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 47/212 (22%), Positives = 110/212 (51%), Gaps = 12/212 (5%)

Query: 81  KEEEGLRAQV---RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
           ++EE +R Q    R  E+  E  ++++ E+K   +E + H  Q E+++E + KM  Q+  
Sbjct: 466 RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD-QEEKIREQEEKMWRQEEK 524

Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
           + R  +E  +E +E +  +E  M+E  +     +M   +++M E+  E ++++ E ++E+
Sbjct: 525 I-REQEEKIREQEEKIREQEEMMQEQEE-----KMGEQEEKMQEQ--EKMRRQEEKIREQ 576

Query: 198 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
            +++    E ++ + E+          Q + ++EQ  ++ +   +M +     +++  K+
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 636

Query: 258 QKLMEKKNQELEVVRQQRERLQEELSQAESTI 289
           ++  EK  ++   +RQQ E++QE     E+ I
Sbjct: 637 RRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%)

Query: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 871
           ++R+ +  EL ++  I  EEL E N +L    + ++S   +    +++++ +LE  + LL
Sbjct: 200 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 258

Query: 872 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 908
            +++ + E     + + ++ A + Q + E+ EL  RLN Q +
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 299



 Score = 33.9 bits (76), Expect = 0.91
 Identities = 21/104 (20%), Positives = 58/104 (55%), Gaps = 5/104 (4%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
           K+ D+E  I+E ++ +  + E++ E   ++   E+K+   +   ++ +E++ + + +++E
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562

Query: 867 TQALLRKKEK--EFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
            + + R++EK  E EE +   +  I + E +  E ++++  Q +
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE 606



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 17/83 (20%), Positives = 48/83 (57%), Gaps = 3/83 (3%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
           K+ ++E  I E ++ ++ + E + E   ++   E+K+   +   ++ +E++ + + ++ E
Sbjct: 586 KIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645

Query: 867 TQALLRKKEKEFEETMDALQADI 889
            +  LR++E++ +E  + L+A I
Sbjct: 646 QEVRLRQQEEKMQEHQEHLEAAI 668



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 20/113 (17%), Positives = 55/113 (48%), Gaps = 10/113 (8%)

Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLE----------KKLDSAAKDADERIEK 859
           K+ ++E  I+E ++ ++ + E + E   ++   E          ++L+    + +E+I +
Sbjct: 322 KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE 381

Query: 860 VQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
           ++ ++ E + +  ++EK  EE     Q    + EA+    ++++  Q ++  E
Sbjct: 382 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,662,005
Number of Sequences: 37866
Number of extensions: 2109321
Number of successful extensions: 37511
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 1652
Number of HSP's that attempted gapping in prelim test: 14427
Number of HSP's gapped (non-prelim): 13031
length of query: 1144
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1031
effective length of database: 13,968,660
effective search space: 14401688460
effective search space used: 14401688460
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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