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Search of human proteins with 13259508
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
(1144 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 2196 0.0
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 2189 0.0
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 2180 0.0
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 2148 0.0
gi|156104908 myosin heavy chain 6 [Homo sapiens] 106 1e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 99 2e-20
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 2e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 97 7e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 96 1e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 96 1e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 96 1e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 96 1e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 95 4e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 4e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 4e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 6e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 94 7e-19
gi|16262452 cingulin [Homo sapiens] 94 1e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 92 4e-18
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 5e-18
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 91 5e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 91 5e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 91 5e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 91 5e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 91 5e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 91 5e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 91 5e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 91 5e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 91 5e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 91 6e-18
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 2196 bits (5690), Expect = 0.0
Identities = 1144/1144 (100%), Positives = 1144/1144 (100%)
Query: 1 MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP
Sbjct: 1 MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
Query: 61 IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ
Sbjct: 61 IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
Query: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
Query: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL
Sbjct: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
Query: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL
Sbjct: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
Query: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
Query: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD
Sbjct: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
Query: 421 FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR
Sbjct: 421 FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
Query: 481 LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL
Sbjct: 481 LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH
Sbjct: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
Query: 601 LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI
Sbjct: 601 LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
Query: 661 RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP
Sbjct: 661 RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
Query: 721 LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA
Sbjct: 721 LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS
Sbjct: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK
Sbjct: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
Query: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL
Sbjct: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
Query: 961 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ
Sbjct: 961 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
Query: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR
Sbjct: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
Query: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140
PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS
Sbjct: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140
Query: 1141 RLIS 1144
RLIS
Sbjct: 1141 RLIS 1144
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 2189 bits (5673), Expect = 0.0
Identities = 1140/1142 (99%), Positives = 1142/1142 (100%)
Query: 3 RQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 62
++APTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII
Sbjct: 137 KKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPII 196
Query: 63 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 122
PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE
Sbjct: 197 PTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE 256
Query: 123 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE
Sbjct: 257 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 316
Query: 183 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR
Sbjct: 317 RAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVR 376
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA
Sbjct: 377 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 436
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV
Sbjct: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK
Sbjct: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 556
Query: 423 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI
Sbjct: 557 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 616
Query: 483 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 542
CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ
Sbjct: 617 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQ 676
Query: 543 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 602
CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA
Sbjct: 677 CSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLA 736
Query: 603 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 662
EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ
Sbjct: 737 EQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQ 796
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 722
FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA
Sbjct: 797 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLA 856
Query: 723 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 782
ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER
Sbjct: 857 ENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAER 916
Query: 783 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL
Sbjct: 917 PPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 976
Query: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR
Sbjct: 977 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1036
Query: 903 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 962
LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ
Sbjct: 1037 LNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQ 1096
Query: 963 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1022
ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL
Sbjct: 1097 ISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLL 1156
Query: 1023 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1082
ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG
Sbjct: 1157 ETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPG 1216
Query: 1083 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1142
ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL
Sbjct: 1217 ATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRL 1276
Query: 1143 IS 1144
IS
Sbjct: 1277 IS 1278
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 2180 bits (5649), Expect = 0.0
Identities = 1139/1144 (99%), Positives = 1139/1144 (99%), Gaps = 5/1144 (0%)
Query: 1 MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP
Sbjct: 1 MMRQAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAP 60
Query: 61 IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ
Sbjct: 61 IIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQ 120
Query: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA 180
Query: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL
Sbjct: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
Query: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL
Sbjct: 241 VRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
Query: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
Query: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD
Sbjct: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
Query: 421 FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR
Sbjct: 421 FKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPR 480
Query: 481 LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL
Sbjct: 481 LICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH
Sbjct: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIH 600
Query: 601 LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI
Sbjct: 601 LAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
Query: 661 RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP
Sbjct: 661 RQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAP 720
Query: 721 LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA
Sbjct: 721 LAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS
Sbjct: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK
Sbjct: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
Query: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
QRLNSQSKRTIEGLRGPPPSGIATLVSGIAG GAIPGQAPGSVPGPGLVKDSPLLL
Sbjct: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLL 955
Query: 961 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ
Sbjct: 956 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1015
Query: 1021 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR
Sbjct: 1016 LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1075
Query: 1081 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1140
PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS
Sbjct: 1076 PGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHS 1135
Query: 1141 RLIS 1144
RLIS
Sbjct: 1136 RLIS 1139
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 2148 bits (5565), Expect = 0.0
Identities = 1125/1135 (99%), Positives = 1126/1135 (99%), Gaps = 6/1135 (0%)
Query: 11 TTTRRPK-PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 69
TT + K PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS
Sbjct: 124 TTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 183
Query: 70 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 129
PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS
Sbjct: 184 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 243
Query: 130 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ
Sbjct: 244 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303
Query: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS
Sbjct: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363
Query: 250 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML
Sbjct: 364 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423
Query: 310 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 369
TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV
Sbjct: 424 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 483
Query: 370 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 429
EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK
Sbjct: 484 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 543
Query: 430 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 489
AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR
Sbjct: 544 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 603
Query: 490 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549
KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK
Sbjct: 604 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 663
Query: 550 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT
Sbjct: 664 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 669
MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR
Sbjct: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 783
Query: 670 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 729
RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV
Sbjct: 784 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 843
Query: 730 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 789
AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP
Sbjct: 844 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 903
Query: 790 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849
VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA
Sbjct: 904 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 963
Query: 850 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR
Sbjct: 964 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023
Query: 910 TIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 969
TIEGLRGPPPSGIATLVSGIAG GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH
Sbjct: 1024 TIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 1078
Query: 970 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1029
ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS
Sbjct: 1079 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1138
Query: 1030 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1089
THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF
Sbjct: 1139 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1198
Query: 1090 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1144
ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
Sbjct: 1199 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 106 bits (265), Expect = 1e-22
Identities = 188/960 (19%), Positives = 389/960 (40%), Gaps = 154/960 (16%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 128
K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K
Sbjct: 912 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971
Query: 129 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
+ E+ A L + + KE K EA ++ ++++ D + + K E+
Sbjct: 972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031
Query: 183 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLKQLE----E 231
+ + L+ +E K+ R+D +L DL++ + I + +D +LK+ E +
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 232 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
QN++++D V L K+ ++++L E ELE R R ++++ S ++E
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEE----ELEAERTARAKVEKLRSDLSRELEE 1147
Query: 292 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
+ E+++ A GA + +EM R ++ R+L E EA L++ ++ E
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1204
Query: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
L EQ+D ++ +K + + D +++ + A+L+ V+R L +Q +
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Query: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 460
++ DF + A+ + + +L + E ++Q R T M D
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE 1324
Query: 461 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 501
+ HDC L+ + R++ KA Q + K+E +
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 502 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 557
E + ++L A V ++ S L+ T HR ++ + VDV ++ +
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1443
Query: 558 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 616
+ +R+ D L E K + ++ +A L+ + A + + +H+
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1497
Query: 617 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 675
+ + + E+ L L +GG+ ++ + + LE +++ ++ + +
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557
Query: 676 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 725
+ A L F + + + +++ VV LQ A + + +
Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617
Query: 726 GLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPS 785
+ L E+ + S ++ + ++ ++L T +L A++ + E
Sbjct: 1618 KKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 786 KPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL--- 842
VE R L+AE LE+ V+++ ++S K+ +EL E + R+ LL
Sbjct: 1676 ----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721
Query: 843 -------EKKLDS--------------AAKDADERIEKVQT----------RLEETQALL 871
+KK++S ++A+E+ +K T + ++T A L
Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781
Query: 872 RKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTIEGLRG 916
+ +K E+T+ LQ +D+ LEA EL+ L ++ KR E ++G
Sbjct: 1782 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKG 1841
Score = 77.8 bits (190), Expect = 5e-14
Identities = 163/845 (19%), Positives = 342/845 (40%), Gaps = 103/845 (12%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKSKMQEQQADL 138
KE ++ + ++E LE +R E + K+ L EK+ +QL+ E Q+ D
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-----QDNLNDA 903
Query: 139 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
+ R + K K LEAK + M E + + + K+ L+ E LK+ +
Sbjct: 904 EERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLEDECSELKKDI 956
Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
D DLE+ A++E++ A+ ++K L E+ A L + + ++ + EK +
Sbjct: 957 D----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TKEK------K 999
Query: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLE 317
L E Q L+ ++ + +++ LS+++ +++ + ++ +L E+ V M +R LE
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV-NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058
Query: 318 EKVRELRETVGDLEAMNEMNDELQ--ENARETELELREQ---LDMAGARVREAQKRVEAA 372
++ +E++ DLE ND+LQ E ++ E ++ +Q ++ + QK+++
Sbjct: 1059 GDLKLTQESIMDLE-----NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113
Query: 373 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 432
Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++ K
Sbjct: 1114 QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEMNKKRE 1170
Query: 433 KAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 490
+ R +E A Q + L DS G D + + K +L ++
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQKLEKE 1222
Query: 491 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 550
+++ K EL + S + A + L + + L + +L+ + K
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAK 1281
Query: 551 VGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTM 610
+ + E++ + LI L + +L T +E L + + E+
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL------------EEEGKAKN 1329
Query: 611 QLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR 670
LA ++ + D + Q +E A L R L + S++ Q+ K
Sbjct: 1330 ALAHALQSARHDCDLLRE---------QYEEETEAKAELQRVLSKANSEVAQWRTKYE-- 1378
Query: 671 MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA 730
TDA Q ++ L + +K L + +E A + L + + L
Sbjct: 1379 ---TDA----------IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425
Query: 731 ALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 790
+E+L +++ + R IL K + E E + S +
Sbjct: 1426 EIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Query: 791 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA 850
A + E + ++ + I +L + L G+ + E L + K+L+
Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE----LEKVRKQLEVEK 1539
Query: 851 KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRT 910
+ +E+ + LE + + + + EF + ++A+I++ AEK E ++ +R
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 911 IEGLR 915
++ L+
Sbjct: 1596 VDSLQ 1600
Score = 74.3 bits (181), Expect = 6e-13
Identities = 178/884 (20%), Positives = 366/884 (41%), Gaps = 134/884 (15%)
Query: 78 SPSKEEEGLRAQVRDLEEKLET-----LRLKRAEDKAK---------LKELEKHKIQLEQ 123
S SK + L QV DLE LE + L+RA+ K + + +LE K+QLE+
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 124 --------VQEWKSKMQEQQA---DLQRRLKEAR---KEAKEALEAKER----------- 158
+ + SK++++Q LQ++LKE + +E +E LEA+
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 159 YMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSD 218
E+ + ++ +E A + E + + E + ++ ++E T E A + +K +D
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 219 GAASSYQ----LKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE-VVRQ 273
A + L++++++ + K D +S ++ +K + +EK ++ LE +
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260
Query: 274 QRERLQE----------ELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVREL 323
R +L+E + ++ ++ EL Q++ E ++ LT L+ +++ +L
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK---EALISQLTRGKLSYTQQMEDL 1317
Query: 324 -RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQT 382
R+ + +A N + LQ + +L LREQ + E Q+ + A VA ++
Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKANSEVAQWRT- 1375
Query: 383 IKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
KY Q T L++ ++L + + + E E + K E H E+E
Sbjct: 1376 --KYETDAIQRTEELEEAKKKLAQRLQDAEEAV-----EAVNAKCSSLEKTKHRLQNEIE 1428
Query: 439 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFEL 498
++V ++N + L + + D +L AE +K + + EL
Sbjct: 1429 DLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWKQKYEESQSEL 1469
Query: 499 SENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEM 558
+ E R + E SL L+ T R L + D+ +++G E
Sbjct: 1470 ESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLTEQLG----EG 1521
Query: 559 SAHERSLDFLIELLHKDQLDETVNVEP------------LTKAIKYYQHLYSIH--LAEQ 604
+ L+ + + L ++L+ +E L +++ Q I LAE+
Sbjct: 1522 GKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581
Query: 605 PEDCTMQLADH---IKFTQSALDCMSV---EVGRLRAFLQGGQEATDIALLLRDLETSCS 658
E+ +H + Q++LD + EV R++ ++G + ++ + L +
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEIQLSHANRMAA 1639
Query: 659 DIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL- 717
+ ++ K ++ + T + A+ + + + + + A L+E+ A Q
Sbjct: 1640 EAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1698
Query: 718 -IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 776
LAE E L+ E + Q+ + ++S ++ + L +++ A+QE
Sbjct: 1699 RSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 777 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 836
E+ + A L+ E + L ++ E IK+L+ L + E+++
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-EAEQIALKG 1809
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 880
+ L +KL++ ++ + +E Q R E+ +RK E+ +E
Sbjct: 1810 GKKQL--QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Score = 63.9 bits (154), Expect = 8e-10
Identities = 65/310 (20%), Positives = 132/310 (42%), Gaps = 58/310 (18%)
Query: 98 ETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE 157
E LR+K+ + +L + +IQL ++ Q+Q LQ LK+ + + +A+ A +
Sbjct: 1612 EVLRVKKKMEG----DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 158 RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS 217
E +A + E R LQ E+E L+ V++ ++ + E+ E
Sbjct: 1668 DLKENIA--------------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE--- 1710
Query: 218 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER 277
+S +++ L QN L + +K+ L +L + + ++ R E+
Sbjct: 1711 ----TSERVQLLHSQNT----------SLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756
Query: 278 LQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE--------------- 322
++ ++ A +ELK++ D + E M + + +L+ ++ E
Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816
Query: 323 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
+RE G+LEA + N E + R++E ++E + E +K + Q+ V
Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDKKNLLRLQDLVDK 1872
Query: 379 YQQTIKKYRQ 388
Q +K Y++
Sbjct: 1873 LQLKVKAYKR 1882
Score = 57.8 bits (138), Expect = 6e-08
Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 49/276 (17%)
Query: 93 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 141
L+ +LE LR +++ E KL E E ++QL Q K KM+ LQ
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE
Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1802
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
+I KG KQL++ AR+++ + +E++ + + K M
Sbjct: 1803 E--------QIALKGGK--------KQLQKLEARVRE----LEGELEAEQKRNAESVKGM 1842
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN------ 315
K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902
Query: 316 ------------LEEKVRELRETVGDLEAMNEMNDE 339
E +V +LR D+ A +M+DE
Sbjct: 1903 HELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDE 1938
Score = 34.7 bits (78), Expect = 0.53
Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 5/172 (2%)
Query: 734 ELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELR 793
+L FK + + +++ + T+ K +E E + ++L+
Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892
Query: 794 AAALRAEITDAEGLGLKLEDR----ETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849
A + + DAE +L E +KE+ + L+ + E +E + LE +
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 850 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
KD D+ +E ++E+ + K K E M L I +L EK L++
Sbjct: 953 KKDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 99.4 bits (246), Expect = 2e-20
Identities = 190/965 (19%), Positives = 388/965 (40%), Gaps = 164/965 (16%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 128
K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKH 969
Query: 129 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
+ E+ A L + + KE K EA ++ ++++ D + T K E+
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 183 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLK----QLEE 231
+ + L+ +E K+ R+D +L DL++ + I + +D +LK +L
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 232 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
NAR++D + L S +++ +LQ +E+ +ELE R R ++++ S ++E
Sbjct: 1090 LNARIEDE----QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Query: 292 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 350
+ E+++ A GA + +EM R ++ R+L E EA L++ ++ E
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1202
Query: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
L EQ+D ++ +K + + D +++ + A+L+ + R L +Q +
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262
Query: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 460
++ D + A+ + + +L + E ++Q R T + D
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 461 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 501
+ HDC L+ + R++ KA Q + K+E +
Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382
Query: 502 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 557
E + ++L A V ++ S L+ T HR ++ + VDV ++ +
Sbjct: 1383 TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1441
Query: 558 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 616
+ +R+ D L E K + ++ +A L+ + A + + +H+
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1495
Query: 617 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 675
+ + + E+ L L G+ ++ + + LE +++ ++ + +
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 676 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 725
+ A L F + + + +++ VV LQ A + + NE
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR-----SRNE 1610
Query: 726 GLLVAA-----LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
L V L E+ + S ++ + ++ ++L T +L A++ +
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E VE R L+AE LE+ V+++ ++S K+ +EL E + R+
Sbjct: 1669 ENIAI----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQ 1714
Query: 841 LL----------EKKLDS--------------AAKDADERIEKVQT----------RLEE 866
LL +KK+D+ ++A+E+ +K T + ++
Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774
Query: 867 TQALLRKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTI 911
T A L + +K E+T+ LQ +D+ LEA EL+ L ++ KR
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 912 EGLRG 916
E ++G
Sbjct: 1835 ESVKG 1839
Score = 86.7 bits (213), Expect = 1e-16
Identities = 177/854 (20%), Positives = 346/854 (40%), Gaps = 105/854 (12%)
Query: 74 PPLPSPSKEEE--GLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKS 129
P L S +E+E ++ + L+E LE +R E + K+ L EK+ +QL+ E
Sbjct: 838 PLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--- 894
Query: 130 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
Q+ AD + R + K K LEAK + M E + + + K+ L+
Sbjct: 895 --QDNLADAEERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLED 945
Query: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
E LK +D DLE+ A++E++ A+ ++K L E+ A L + + ++ +
Sbjct: 946 ECSELKRDID----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TK 994
Query: 250 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ V M
Sbjct: 995 EK------KALQEAHQQALDDLQAEEDKV-NTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 310 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARVREAQK 367
+R LE ++ +E++ DLE + DE + ++ EL L +++ A + QK
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDE-RLKKKDFELNALNARIEDEQALGSQLQK 1106
Query: 368 RVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAE 427
+++ Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEM 1163
Query: 428 TKAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKA 485
K + R +E A Q + L DS G D + + K
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQ 1215
Query: 486 ELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSV 545
+L +++++ K EL + S + A L Q HR + +Q SV
Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----QMNEHRSKAEETQRSV 1270
Query: 546 -DVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ + L E R LD ++ + LT+ Y +Q
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLD-----------EKEALISQLTRGKLTY--------TQQ 1311
Query: 605 PEDCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR 661
ED QL + +K + AL + LR Q +E A L R L + S++
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE--QYEEETEAKAELQRVLSKANSEVA 1369
Query: 662 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 721
Q+ K TDA Q ++ L + +K L + +E A + L
Sbjct: 1370 QWRTKYE-----TDA----------IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Query: 722 AENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAE 781
+ + L +E+L +++ + R IL K + E E +
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 782 RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL 841
S + A + E + ++ + I +L + L G+ + E L
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE----LEK 1528
Query: 842 LEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
+ K+L++ + +E+ + LE + + + + EF + ++A+I++ AEK E +
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEME 1584
Query: 902 RLNSQSKRTIEGLR 915
+ R ++ L+
Sbjct: 1585 QAKRNHLRVVDSLQ 1598
Score = 80.5 bits (197), Expect = 8e-15
Identities = 166/832 (19%), Positives = 334/832 (40%), Gaps = 101/832 (12%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E L A++ D + L+ K E +A+++ELE+ +LE + ++K+++ ++DL R
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEE---ELEAERTARAKVEKLRSDLSRE 1142
Query: 142 LKEARKEAKEA-------LEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEVEA 193
L+E + +EA +E ++ E +E ATL E A + V
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
L E++D +L+ +K ++E++ S+ + EQ + K L +M + E
Sbjct: 1203 LGEQID----NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258
Query: 254 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
H + E+ + + + QR +LQ E + +DE E ++ LT
Sbjct: 1259 H---RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE----------KEALISQLTRGK 1305
Query: 314 LNLEEKVREL-RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
L +++ +L R+ +++A N + LQ + +L LREQ + E Q+ + A
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKA 1364
Query: 373 QETVADYQQTIKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
VA ++ KY Q T L++ ++L + + + E E + K E
Sbjct: 1365 NSEVAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAV-----EAVNAKCSSLEK 1416
Query: 429 KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELI 488
H E+E ++V ++N + L + + D +L AE
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWK 1457
Query: 489 RKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY 548
+K + + EL + E R + E SL L+ T R L + D+
Sbjct: 1458 QKYEESQSELESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLT 1513
Query: 549 KKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 598
+++GS + ++ A + L +E E + L +++ Q
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAE 1571
Query: 599 IH--LAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRAFLQGGQEATDIALLL 650
I LAE+ E+ +H++ S + E R++ ++G + ++ + L
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG--DLNEMEIQL 1629
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
++ ++ K ++ + T + A+ + + + + + A L+E+
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 711 AAAAAQL--IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNK 768
A Q LAE E L+ E + Q+ + ++S ++ L +
Sbjct: 1689 RAVVEQTERSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMDADLSQLQTE 1740
Query: 769 LATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIK 828
+ A+QE E+ + A L+ E + L ++ E IK+L+ L +
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-E 1799
Query: 829 GEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 880
E+++ + L +KL++ ++ + +E Q R E+ +RK E+ +E
Sbjct: 1800 AEQIALKGGKKQL--QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Score = 65.5 bits (158), Expect = 3e-10
Identities = 85/429 (19%), Positives = 188/429 (43%), Gaps = 71/429 (16%)
Query: 84 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQRRL 142
E + + ++L+E++ L + + ELEK + QLE + E +S ++E +A L+
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERV--- 198
+ + E + K ++A+ + +E A + + + SL E + E +
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL--SSSEKQEHVK 256
++ DL ++ ++ A + Q+K L+ + LKD +++ D ++ + +E++
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLLKDTQIQLDDAVRANDDLKENIA 1672
Query: 257 L----QKLMEKKNQELEVVRQQRER--------------------------------LQE 280
+ L++ + +EL V +Q ER +
Sbjct: 1673 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732
Query: 281 ELSQAESTIDELKEQ------------VDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 328
+LSQ ++ ++E ++ DAA+ AEE+ + D + +LE + + +T+
Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIK 1791
Query: 329 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ----ETVADYQQTIK 384
DL+ DE ++ A + ++QL ARVRE + +EA Q E+V +++ +
Sbjct: 1792 DLQ---HRLDEAEQIALKGG---KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 385 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 444
+ ++LT ++ + L Q+ + + Q + + + + AE +A+ + Q E+
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQD--LVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Query: 445 AQANRHMSL 453
+A +
Sbjct: 1904 DEAEERADI 1912
Score = 57.0 bits (136), Expect = 1e-07
Identities = 61/266 (22%), Positives = 122/266 (45%), Gaps = 32/266 (12%)
Query: 93 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 141
L+ +LE LR +++ E KL E E ++QL Q K KM + LQ
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
+I KG KQL++ AR+++ + + +E++ + + K M
Sbjct: 1801 E--------QIALKGGK--------KQLQKLEARVRE----LENELEAEQKRNAESVKGM 1840
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+ KV+
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1900
Query: 322 -ELRETVGDLEAMNEMNDELQENARE 346
EL E + ++L+ +R+
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRD 1926
Score = 50.4 bits (119), Expect = 9e-06
Identities = 128/633 (20%), Positives = 250/633 (39%), Gaps = 76/633 (12%)
Query: 296 VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 355
+D+ GAE+++ L + + ++ G L + EM DE R + + R Q
Sbjct: 736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE-----RLSRIITRIQA 790
Query: 356 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
G R K++ ++++ Q I+ + + S ER+++
Sbjct: 791 QSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMA 850
Query: 416 PETFDF-KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLV 474
+F ++K A K+ A+ E+E + + + Q + L D+ + C +
Sbjct: 851 SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQL 908
Query: 475 LLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLH 534
+ +L K + + ++ +++ E++ +E + ++ S + L L A +
Sbjct: 909 IKNKIQLEAKVKEMNERLEDEEEMN---AELTAKKRKLEDECSELKRDIDDLELTLAKVE 965
Query: 535 RYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFL------IELLHKDQLD----ETVNVE 584
+ +HA KV +L EM+ + + L ++ H+ LD E V
Sbjct: 966 KEKHATEN-------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018
Query: 585 PLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEAT 644
LTKA + L +Q +D L K + +++ R + L+G + T
Sbjct: 1019 TLTKA--------KVKLEQQVDDLEGSLEQEKK--------VRMDLERAKRKLEGDLKLT 1062
Query: 645 DIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVV 704
+++ DLE + + KK + +A I A G Q+ L K L +
Sbjct: 1063 QESIM--DLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKL----KELQARI 1115
Query: 705 AVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIS 764
L+E A A + + L LEE++ + E T ++ I
Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT-------------SVQIE 1162
Query: 765 TMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEG-LGLKLEDRETVIKELKK 823
K Q+ D E + E AAALR + D+ LG ++++ + V ++L+K
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219
Query: 824 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 883
E SE + L + ++ K A +EK+ LE+ R K +E + +++
Sbjct: 1220 -------EKSEFKLELDDVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 884 ALQADIDQLEAEKAELKQRLNSQSKRTIEGLRG 916
L + +L+ E EL ++L+ + + RG
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/133 (25%), Positives = 67/133 (50%), Gaps = 13/133 (9%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKM 131
L K+ + L A+VR+LE +LE + + AE +++ E+ Q E+ ++ ++
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 132 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQE 190
Q+ LQ ++K +++A+EA EE A+T + + AEERA+ + +
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEA--------EEQANTNLSKFRKVQHELDEAEERADIAESQ 1916
Query: 191 VEALKERVDELTT 203
V L+ + ++ T
Sbjct: 1917 VNKLRAKSRDIGT 1929
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 99.0 bits (245), Expect = 2e-20
Identities = 247/1088 (22%), Positives = 426/1088 (39%), Gaps = 149/1088 (13%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLK----RAEDKAKLKELEKHKIQLEQ----VQEW 127
L ++ E R+ +E+LE LRL+ R + L+ E+ + LEQ ++
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 128 KSKMQEQQADLQRRL-------KEARKEAKEALEAKERYMEEMADTAD-----AIEMATL 175
+S++QEQ A L R+L ++AR+EA+ +EA ER E A A+++
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888
Query: 176 DKE--MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQN 233
++E E A L+ E EAL+ + E+ L L+A E+ ++G A + L +
Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
Query: 234 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR-------ERLQEELSQAE 286
A L+ ++ ++ +S +K+ + QKL++ + + +R+QR +RLQ E A
Sbjct: 949 AGLRQQIIATQEKASLDKE--LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW 1006
Query: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 346
++ + Q+ + L E E+L LE + EL E + L+ + L E+ ++
Sbjct: 1007 RELEAERAQLQSQL-QREQEELLA----RLEAEKEELSEEIAALQQERDEGLLLAESEKQ 1061
Query: 347 TELELREQLDMA------GAR-------------VREAQKRVEAAQETVADYQQTIKKYR 387
L L+E A G R R+AQ R E + TV
Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV----------N 1111
Query: 388 QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQA 447
LT+ L+D+ + A + ++ + D + A+ + +LR +E A+
Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171
Query: 448 NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERP 506
LL A LR + E+ R++A E + L E ER
Sbjct: 1172 GLRRELLEA---QRKLRESQE---------------GREVQRQEAGELRRSLGEGAKERE 1213
Query: 507 GLRGAAGEQLSF---AAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHER 563
LR + E S A SL L + L + V K+ G L + ER
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 564 S-LDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPED----CTMQLADHIKF 618
S L+ EL + + ++ E + + + L E+ E T+ L +
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
Query: 619 TQSALDCM--SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDA 676
+++L+ M ++V + + Q G+ T LL LE + +Q R G +
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR----GLEL 1389
Query: 677 PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELA 736
+ AA A ++ L + A E+A Q A A+ GL A L
Sbjct: 1390 K-LEAARAEAAELGLRLSAAEGRAQGLEA---ELARVEVQRRAAEAQLGGLRSALRRGLG 1445
Query: 737 F-----KASEQIYGTPS-SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 790
A + G+P+ +P E + N ST+ + A P S
Sbjct: 1446 LGRAPSPAPRPVPGSPARDAPAEGSGEGLN-SPSTLECSPGSQPPSPGPATSPASPDLDP 1504
Query: 791 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---D 847
E ALR + + + ++ T L + L E A R L+K + +
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 848 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD-------ALQADIDQLEAEKAELK 900
A + D R+ VQ L + +R+ E+E T+D +LQA +L A + ++
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624
Query: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLL 960
+ +++K +EG + + S E QR ++ G+ S G + D
Sbjct: 1625 KMKANETK--LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG---LSDRE--- 1676
Query: 961 QQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQ 1020
Q A++ + LQ + + +++KA L V +L+ E GAL K
Sbjct: 1677 AQAQALQDRVDSLQRQ---VADSEVKAGTLQLT---VERLNGALAKVEESEGALRDKVRG 1730
Query: 1021 LLETLNQL-----STHTHVVDITRTSPAAKSPSAQLMEQV-----------AQLKSLSDT 1064
L E L Q ST + + + A + L E++ Q SL +
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790
Query: 1065 VEKLKDEV 1072
V+ L+ EV
Sbjct: 1791 VQTLRGEV 1798
Score = 92.4 bits (228), Expect = 2e-18
Identities = 209/947 (22%), Positives = 365/947 (38%), Gaps = 134/947 (14%)
Query: 14 RRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAV 73
R P P R +S G G S GPS + S + ST A A
Sbjct: 491 RTPSPPRRSSPG-RGRSPRRGPSPACS-------DSSTLALIHSA--------------- 527
Query: 74 PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
L + + +R + ++ L TLR + ++ +++ + LE+ QL+++++ +
Sbjct: 528 --LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEE---QLQRLRDKTDGAMQ 582
Query: 134 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
D QR ++ R A E E ++ A ++++A +++AE L+QE E
Sbjct: 583 AHEDAQREVQRLRS-------ANELLSREKSNLAHSLQVA-------QQQAEELRQEREK 628
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGA-------ASSYQLKQLEEQNARLKDALVRMRDL 246
L+ +EL + L+ E E+ DGA S QL+QLE + + L LV +R+
Sbjct: 629 LQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
S + LQ EK + + + R++ ELS + +E Q D+ +
Sbjct: 689 LSRATLQRDMLQ--AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ-DSLSKLSALN 745
Query: 307 EMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETE---LELREQLDMAGARVR 363
E L L+L V +L E L+ ++ ARE + ELR + ++A +
Sbjct: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLE 805
Query: 364 EAQKRVEAAQETVADYQQTIKKYR-QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFK 422
+ + E AQE + T++ R QL L ++R+L+ +++ + ++
Sbjct: 806 GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR---------- 855
Query: 423 IKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLI 482
E + +A+E R+ E A A H L + R G L + +
Sbjct: 856 ----EAQRQVEALERAAREKE-ALAKEHAGLAVQLVAAE--REGRTLSEEATRLRLEKEA 908
Query: 483 CKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFA--------AGLVYSLSLLQATLH 534
+ L Q Q L++ + R L A G+ L A AGL + Q
Sbjct: 909 LEGSLFEVQRQ----LAQLEARREQLE-AEGQALLLAKETLTGELAGLRQQIIATQEKAS 963
Query: 535 RYEHALSQCSVDVYKKV-GSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 593
+ ++Q V ++ SL + +AHE L L + L ++
Sbjct: 964 LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023
Query: 594 QHLYSIHLAEQPEDCTMQLADHIKFTQSALD--CMSVEVGRLRAFLQGGQEATDIALLLR 651
Q L + E +L++ I Q D + E + +A E T ++ L
Sbjct: 1024 QEELLARLEAEKE----ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 652 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
S + I ++ +R A + Q T+ L + A +E A
Sbjct: 1080 GTRHSLATISLEMERQKR-----------DAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
Query: 712 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLAT 771
AA AQ + L E L + +A E LR +L + L
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEE-------------LRTQLRLLEDARDGLRR 1175
Query: 772 AMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETVIKELKK---S 824
+ E + A LR + + E L E+ + +K+ + S
Sbjct: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
Query: 825 LKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA 884
LK+ E+ + +L+LLE+ + K+A E +Q +E ++ R++ +E M
Sbjct: 1236 LKLANEDKEQ---KLALLEEARTAVGKEAGELRTGLQ-EVERSRLEARRELQELRRQMKM 1291
Query: 885 LQADIDQLEAEKAELKQRL------NSQSKRTIEGLRGPPPSGIATL 925
L ++ +L E AEL+ RL +S+R GLR G A+L
Sbjct: 1292 LDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
Score = 78.6 bits (192), Expect = 3e-14
Identities = 191/926 (20%), Positives = 351/926 (37%), Gaps = 122/926 (13%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
+E E LR Q+R LE+ + LR + E + KL+E QE + +++ +L+R
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRES----------QEGREVQRQEAGELRR 1203
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES----LQQEVEALKE 196
L E KE EA R EE+ E + ++A E E L++ A+ +
Sbjct: 1204 SLGEGAKER----EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD-------LSSS 249
EL T L+ ++ E + Q+K L+ +N RL L ++
Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
Query: 250 EKQEHVKLQKLMEKKNQELEVVRQQ----RERLQEELSQAESTIDELKEQVDAALGAE-E 304
++E + L++ + K LEV+RQ+ + +LQE+ + + L ++ A G E +
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
++ L LE E E L A L+ E++ R G +R
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRS 1438
Query: 365 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP---PETFDF 421
A +R + + + A + L + QPP P T
Sbjct: 1439 ALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP- 1497
Query: 422 KIKFAETKAHAKAIEMELRQM--EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMP 479
A +A+ LR+ E+ A R L +
Sbjct: 1498 ----ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTS-----------------ALN 1536
Query: 480 RLICKAELIRKQAQEKF-ELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEH 538
R + + E R A + +L + +E R + +LS G+ L+L + ++ R E
Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEESVRRSER 1593
Query: 539 ALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 598
+ ++D +V +L + A E L E + K + +ET +E + +K
Sbjct: 1594 E-RRATLD---QVATLERSLQATESELRASQEKISKMKANET-KLEGDKRRLK------- 1641
Query: 599 IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLLRDLETSC 657
+ + E T++L + + L + + A Q Q+ D + + D E
Sbjct: 1642 -EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700
Query: 658 SDIRQFCKKIRRRMPGTDAP---------GIPAALAFGPQVSDTLLDCRKHLTWVVA--- 705
++ +++ + + G+ ALA ++ D HL +
Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACE 1760
Query: 706 ----VLQEVAAAAAQLIAPLAENEGLL----------VAALEELAFKASEQIYGTPSSSP 751
VLQE AA Q ++ + L VA LE +A Q+
Sbjct: 1761 HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL-----QQL 1815
Query: 752 YECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKL 811
E LRQ + +N + E ER S ++ A L AE + E L+L
Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGS----LQRALAQLEAEKREVERSALRL 1871
Query: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA-- 869
E ++ ++ + E VRLS + +LD A+ + + Q ++++ +A
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931
Query: 870 -LLRKKEKEFEETMDA------LQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI 922
+L + + +DA LQ ++++L + +A+ ++ L ++ + + +RG +
Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-V 1990
Query: 923 ATLVSGIAGEEQQRGAIPGQAPGSVP 948
+TL G +E +R + P P P
Sbjct: 1991 STL-KGQLQQELRRSSAPFSPPSGPP 2015
Score = 70.1 bits (170), Expect = 1e-11
Identities = 98/439 (22%), Positives = 187/439 (42%), Gaps = 41/439 (9%)
Query: 21 PASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPS 80
PA V G+ + P+ + G + PST +P + P P P TSP SP
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEG---LNSPSTLECSPGSQPPSPGPA-TSPA------SPD 1501
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
+ E +R +R+ ++L + + +R E + + L + ++E ++ + Q
Sbjct: 1502 LDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVA 1561
Query: 141 RLKEARKEAKEAL---EAKERYMEEMADTADAIEMATLDKEMAEERA-ESLQQEVEALKE 196
+EAR+ L +A+ EE ++ ATLD+ ER+ ++ + E+ A +E
Sbjct: 1562 ESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQE 1621
Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR-DLSSSEKQEHV 255
++ ++ + L+ + AS + +LE Q L+ L R R LS E Q
Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681
Query: 256 ------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV----DAALGAEEM 305
LQ+ + + ++ ERL L++ E + L+++V +A +
Sbjct: 1682 LQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
Query: 306 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365
+ D+NL+L+ + L D + + E D AR+ E R+Q G
Sbjct: 1742 LNSTRDKNLHLQ---KALTACEHDRQVLQERLDA----ARQALSEARKQSSSLG------ 1788
Query: 366 QKRVEAAQETVADYQ-QTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIK 424
++V+ + VAD + Q ++ QL L++V R+ + A++ Q+ E + +
Sbjct: 1789 -EQVQTLRGEVADLELQRVEAEGQL-QQLREVLRQRQEGEAAALNTVQKLQDERRLLQER 1846
Query: 425 FAETKAHAKAIEMELRQME 443
+ +E E R++E
Sbjct: 1847 LGSLQRALAQLEAEKREVE 1865
Score = 68.6 bits (166), Expect = 3e-11
Identities = 104/509 (20%), Positives = 209/509 (41%), Gaps = 90/509 (17%)
Query: 15 RPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPST-PAQTPLAAPIIPTPVLTSPGA- 72
RP P PA A S S S S PS PA +P + + P V +
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF 1514
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ--------- 123
+ L S +E + LR Q L +L + +R ++ ++L+K + E+
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 124 --------VQEWKSKMQEQQ--------ADLQRRLKEARKEAKEA-------------LE 154
+QE + E++ A L+R L+ E + + LE
Sbjct: 1575 SGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLE 1634
Query: 155 AKERYMEEMADTADA------IEMATLDKEMAEER---------AESLQQEVEALKERVD 199
+R ++E+ D +++ ++ +L+ E+ R A++LQ V++L+ +V
Sbjct: 1635 GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
+ L+ +E A L ++ L +AL + +S + +++ LQK
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
+ + +V++++ + ++ LS+A L EQV G +E+ + + E +
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL---QRVEAEGQ 1811
Query: 320 VRELRETV-----GDLEAMN---EMNDE----------LQENARETELELRE------QL 355
+++LRE + G+ A+N ++ DE LQ + E E RE +L
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
Query: 356 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
+ +R +VE +E + ++ T++ L+A ++R LT + E Q+Q
Sbjct: 1872 EKDRVALRRTLDKVE--REKLRSHEDTVR----LSAEKGRLDRTLTGAELELAEAQRQ-- 1923
Query: 416 PETFDFKIKFAETKAHAKAIEMELRQMEV 444
+ + ++ E +E++ +Q ++
Sbjct: 1924 IQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Score = 63.5 bits (153), Expect = 1e-09
Identities = 177/868 (20%), Positives = 343/868 (39%), Gaps = 115/868 (13%)
Query: 64 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ 123
+PVL + L S +E + L+ ++ +E+ L R +R E K + + +LEQ
Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQ 120
Query: 124 VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER 183
+ E Q E R ++++E + + EE A ++ ++ +
Sbjct: 121 ALRLEPGELETQ--------EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL 172
Query: 184 AESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM 243
+ LQ ++ K+R EL L E+E+ Q + E + L+ AL+R+
Sbjct: 173 VQRLQGKILQYKKRCSELEQQLLERSGELEQ----------QRLRDTEHSQDLESALIRL 222
Query: 244 RD---LSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQEELSQAESTIDELK 293
+ S+S Q + L++ +++ ++++ V R ++EL E+ +
Sbjct: 223 EEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282
Query: 294 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ---ENARETELE 350
E +A E R L L +V R V +++ E D LQ E AR +
Sbjct: 283 ESFNAYFSNEH------SRLLLLWRQVVGFRRLVSEVKMFTE-RDLLQLGGELARTSRAV 335
Query: 351 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
L ++ +R A+ R EAA ++K L A L++ R+ +++ ++
Sbjct: 336 QEAGLGLS-TGLRLAESRAEAA----------LEKQALLQAQLEEQLRDKVLREKDLAQQ 384
Query: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 470
Q Q + D + E K +E + +E Q N+ ++ + L+ +
Sbjct: 385 QMQSDLDKADLSARVTELGLAVKRLEKQ--NLEKDQVNKDLTEKLEALESLRLQEQAALE 442
Query: 471 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERP------GLRGAAGEQL-------- 516
L L A+ + ++ +LS SER LRG +G++
Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSG--SERTADASNGSLRGLSGQRTPSPPRRSS 500
Query: 517 -----------SFAAGLVYSLSLLQATLHRYEHALS------QCSVDVYKKVGSLYPEMS 559
S A +L+L+ + LH+ + + + S D+ + +
Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560
Query: 560 AHERSLDFLIELLHKDQLDETVNV-EPLTKAIKYYQHLYSIHLAEQPE-----DCTMQLA 613
+ R+L+ ++ L +D+ D + E + ++ + + E+ Q A
Sbjct: 561 SERRALEEQLQRL-RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619
Query: 614 DHIKFTQSALDCMSVEVGRLRAFLQGGQE--ATDIALLLRDLETSCSDIRQFCKKIRRRM 671
+ ++ + L E+ R R L+ QE D A + R+LE S + Q + +R +
Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL--EGKRSV 677
Query: 672 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
+ + AL+ D L A EVA A + A E E ++
Sbjct: 678 LAKELVEVREALSRATLQRDML----------QAEKAEVAEALTKAEAGRVELE---LSM 724
Query: 732 LEELAFKASEQIYGTPSSSPYECLRQ---SCNILISTMNKLATAMQEGEYDAERPPSKPP 788
+ A +AS Q + S+ E L Q N L++ + + +A+Q + AE+ +
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 789 PVELRAAALRAEITDA-EGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLD 847
+ R LR E A +GL L E + L++ L E S+ +L+ L ++L
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
Query: 848 SAAKDADERIEKVQTRLEETQALLRKKE 875
++ ++ + Q ++E + R+KE
Sbjct: 845 GREQELEQARREAQRQVEALERAAREKE 872
Score = 50.8 bits (120), Expect = 7e-06
Identities = 214/1026 (20%), Positives = 391/1026 (38%), Gaps = 153/1026 (14%)
Query: 189 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
QEVE E V + T + +L +EKG GA Q Q+ A +++ + R +LS
Sbjct: 9 QEVELTLETVIQ-TLESSVL---CQEKGL-GARDLAQDAQITSLPALIREIVTR--NLSQ 61
Query: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
E + ++ L ++++ + LQ+ELS+ E + + + + D V
Sbjct: 62 PESPVLLPATEMAS-----LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE 116
Query: 309 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
++ L LE E +E G + E+ +LQE +L+ + + R+AQ
Sbjct: 117 RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE---GQQRQAQ-L 172
Query: 369 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
V+ Q + Y+ K+ +L L + + EL Q+ E Q + + +
Sbjct: 173 VQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229
Query: 429 KAHAKAIEMELRQMEVA-QANRHMSLLTAFMPDSFLRP---------------------- 465
+ A+ M Q++ A AN+ +S + + + R
Sbjct: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289
Query: 466 GGDHDCVLVL----LLMPRLICKAELIRK----QAQEKFELSENCSERPGLRGAAGEQL- 516
+H +L+L + RL+ + ++ + Q + + + GL + G +L
Sbjct: 290 SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349
Query: 517 -SFAAGLVYSLSLLQA---------TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
S A + +LLQA L + A Q D+ K ++SA L
Sbjct: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK------ADLSARVTELG 403
Query: 567 FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCM 626
++ L K L++ + LT+ + + L S+ L EQ ++ D Q+ D
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKL---EALESLRLQEQ---AALETEDGEGLQQTLRDL- 456
Query: 627 SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFG 686
+A L + ++ R + S +R + P +PG + G
Sbjct: 457 ------AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510
Query: 687 PQV----SDTLLDCRKHLTWVVAVLQEVAA---AAAQLIAPL------AENEGLLVAALE 733
P S TL L +Q++ A+ L+ L +E+E ALE
Sbjct: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESER---RALE 567
Query: 734 ELAFKASEQIYGT-----PSSSPYECLRQSCNILISTMNKLATAMQEGEYDA-----ERP 783
E + ++ G + + LR + +L + LA ++Q + A ER
Sbjct: 568 EQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627
Query: 784 PSKPPPVELRAAALRAE------ITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANV 837
+ ELR R E + D + +LE +++L+ + +EL E
Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687
Query: 838 RLS--LLEKKLDSAAK----DADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQ 891
LS L++ + A K +A + E + LE + LR +E ++++ L A +
Sbjct: 688 ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNES 747
Query: 892 LEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPG 951
L +K +L RL +Q + L+G A + +A EEQ+R + V G
Sbjct: 748 LAQDKLDL-NRLVAQLEEEKSALQGRQRQ--AEQEATVAREEQER-LEELRLEQEVARQG 803
Query: 952 LVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPA 1011
L + Q A+ + L+HE S L+ +A+LS + G E
Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQE-------------QLAQLSRQLSGREQEL 850
Query: 1012 GALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDE 1071
R+ + +E L + + + A QL+ + ++LS+ +L+ E
Sbjct: 851 EQARREAQRQVEALERAAREKEALAKEHAGLA-----VQLVAAEREGRTLSEEATRLRLE 905
Query: 1072 VLKETVSQRPGATVPTDFATFPSSAFLRAKEEQ---QDDTVYMGKVTFSCAAGFGQRHRL 1128
KE A + F A L A+ EQ + + + K T + G R ++
Sbjct: 906 --KE-------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA-GLRQQI 955
Query: 1129 VLTQEQ 1134
+ TQE+
Sbjct: 956 IATQEK 961
Score = 36.2 bits (82), Expect = 0.18
Identities = 55/280 (19%), Positives = 113/280 (40%), Gaps = 37/280 (13%)
Query: 9 RKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLT 68
R+ R R A + SSSLG GE++ E +
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
Query: 69 SPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 128
G L + K L+ + R L+E+L +L+ A+ +A+ +E+E+ ++LE
Sbjct: 1823 QEGEAAALNTVQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE------ 1872
Query: 129 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
+ + L+R L + +E + E R E + A L+ A+ + + L+
Sbjct: 1873 ----KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE 1928
Query: 189 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM-RDLS 247
+V L++ +++ + ++E L+++ RL+ A + R L
Sbjct: 1929 AQVVVLEQSHSPAQLEVDAQQQQLE---------------LQQEVERLRSAQAQTERTLE 1973
Query: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 287
+ E+ +++ L E+ V + +LQ+EL ++ +
Sbjct: 1974 ARERAHRQRVRGLEEQ-------VSTLKGQLQQELRRSSA 2006
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 97.4 bits (241), Expect = 7e-20
Identities = 208/949 (21%), Positives = 367/949 (38%), Gaps = 154/949 (16%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-------KHKIQLEQVQEWKSKMQE 133
+E+ L +V +L+ +ET R ++ E +A++ ELE + + E+V + K ++QE
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702
Query: 134 QQADLQRRLK-------EARKEAKEALEAKERYMEEM-ADTADAIEMATLD-KEMAEERA 184
Q L+ LK E ++ A +ALE ++R + E+ A+T +E + KE+ EERA
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 185 -------------ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQL 229
E+ Q E E L+ + E ++E E+ + AA Y+ Q
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 230 EE--QNARLKDALVRMRDLSSSEKQEHVKLQKLMEK-----KNQELEVVRQQRERLQEEL 282
EE A ++ L+ +++ +QE LQ+ EK + EL++ RQ Q EL
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQE---LQEAKEKVAGIESHSELQISRQ-----QNEL 874
Query: 283 SQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQE 342
++ + + +QV E + L D L+EK+ + V LE + E QE
Sbjct: 875 AELHANLARALQQVQE---KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931
Query: 343 NARETELELREQLDMAGARVRE------------AQKRVEAAQETVADYQQTIKKYRQLT 390
A EL ++ AG R E Q ++A + +++ R
Sbjct: 932 TASR---ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
Query: 391 AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRH 450
Q +E QQE V R Q E + A KA +EM L+ Q
Sbjct: 989 MESQGQQQEERGQQEREVARLTQ---ERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045
Query: 451 MSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERPGLR 509
+L A + G D + + L I + E +R+ ++ K +L++ E
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Query: 510 GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERS---LD 566
GA E L L+A + + E QC ++ SL + A S D
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLE---QQCQKQ-QEQADSLERSLEAERASRAERD 1161
Query: 567 FLIELLHKDQLDETVN--------VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLA---DH 615
+E L + QL+E + + + ++ H ++ ++ Q+A
Sbjct: 1162 SALETL-QGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH-SKAEDEWKAQVARGRQE 1219
Query: 616 IKFTQSALDCMSVEVGRL-RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
+ S + + EV L R L+ E+ ++ L+ + + + ++
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASN 1279
Query: 675 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
A + A +V + K + QE+ + A + AE G + A +E
Sbjct: 1280 SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER-----AEELGQELKAWQE 1334
Query: 735 LAFKASEQIYGTPSSSPYECLRQSCNILISTM---NKLATAMQEGEYDAER------PPS 785
F+ + + S + S L+S + L +Q + AE+ S
Sbjct: 1335 KFFQKEQAL------STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
Query: 786 KPPPVELRAAALRA--EITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---------- 833
K LRA LRA E+ + L K+ ++E ++L+ E+LS
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
Query: 834 --------EANVRLSLLEKKLDSAAK-----------DADERIEKVQTRLEETQALLR-- 872
AN+ LE +LD A + DA+ R+ +VQ + T L
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508
Query: 873 ------------KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
++ + F+E L A ++QLE + E +++ SK+
Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
Score = 92.8 bits (229), Expect = 2e-18
Identities = 226/1108 (20%), Positives = 419/1108 (37%), Gaps = 195/1108 (17%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ------------VQEWK 128
K+ + L+ + ++ K+ L + + KL+E H QL+ QEW
Sbjct: 297 KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 356
Query: 129 SKMQEQQADLQRRL--KEARKEAKEALEAK----ERYMEEMADT---------ADAIEMA 173
K + + +L L K+ +E E L+ K E ++ ++ D D +++
Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
Query: 174 TLDKEMA---------EERAESL-----QQEVEALKER---------VDELTTDLEI--- 207
TL +E A + R E L QQE + L ER + L TDL+
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476
Query: 208 ----LKAEIEEKG-SDGAASSYQLKQLEEQ----NARLKDALVRMRDLSSSEKQEHVKLQ 258
K E+E+ + GA + Q+ L + NA ++ + L K++ +L
Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536
Query: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA---------ALGAEEMVEML 309
+ ++++ Q + +R Q E+L L Q E + E+ E+ +A A AEE L
Sbjct: 537 QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 310 TDRNLNL-------EEKVRELRETVGDLEAMNEMNDELQEN---ARETELELREQLDMAG 359
+R+ L +EK +L L+ NE D Q + A+ + EL +++
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 360 ARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE-------------A 406
A V A++ AQ VA+ + ++ +Q + V +E QE
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 407 SVERQQQPPPETFDFKIKF-----AETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 461
S+E +++ + + + + AET++ + + E +++E +A R +
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR------KGLEAR 770
Query: 462 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE--LSENCSERPGLRGAAGEQLSFA 519
+ G H +L R + +A + A+ + E + E + R + E+ +
Sbjct: 771 LQQLGEAHQAETEVL--RRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 520 AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDE 579
A L L+ + L + +KV + +H EL Q +E
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAK----EKVAGI----ESHS-------ELQISRQQNE 873
Query: 580 TVNVEP-LTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQ 638
+ L +A++ Q + E +LAD + Q + S EV RL ++
Sbjct: 874 LAELHANLARALQQVQ---------EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 639 --GGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDC 696
G Q+ T L+++ + ++ ++ + R + + A Q+ + L
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 697 RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA--ALEELAFKASEQIYGTPSSSPYEC 754
R L QE + +A L + G A ALE+ A E
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-------RLQNA 1037
Query: 755 LRQSCNILISTMNKLATAMQEGE-YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLED 813
L + + LA A+ E E D E + L AA ++ +LE+
Sbjct: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLR----GLEAAQIK-----------ELEE 1082
Query: 814 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRK 873
+K+LK+ L K +E + + A +A R E +LE +A + K
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGS-----------GAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 874 KEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEE 933
E++ ++ + + LEAE+A +R + T++G + S +A +
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSALASAQ 1189
Query: 934 QQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLP 993
++ A + K Q++ R + + +NS++ + + S+
Sbjct: 1190 RELAAFRTKVQDHSKAEDEWK------AQVARGR---QEAERKNSLISSLEEEVSI---- 1236
Query: 994 PLHVAKLSHEGPGSELP--AGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQL 1051
L+ L EG EL A K+ +L E L L T S A S+ L
Sbjct: 1237 -LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAET-----ASNSARAAERSSAL 1290
Query: 1052 MEQVAQLKSLSDTVEKLKDEVLKETVSQ 1079
E+V L+ ++ + + +E SQ
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQ 1318
Score = 87.8 bits (216), Expect = 5e-17
Identities = 209/1042 (20%), Positives = 418/1042 (40%), Gaps = 120/1042 (11%)
Query: 89 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQL--------EQVQEWKSKMQEQQADLQR 140
++ +L +K E+L ++ E + ++L+ K Q+ E+ + K++E + LQ+
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
+ +E +A + ++E+ A + A DK+ EE+ E LQ ++ L+E + +
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
L + K E+ QL+ L+++ A L+++ Q +++ L
Sbjct: 397 LQDNPPQEKGEV-------LGDVLQLETLKQEAA----------TLAANNTQLQARVEML 439
Query: 261 MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTD-RNLNLEEK 319
++ Q+ + +R +EE Q S I +L+ + A+E +E + L +
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 320 VRELRETVGDLEAMNEMNDE----LQENARETELELREQLDMAGARVREAQKRVEAAQET 375
V L + L A + D+ L++ A+E + +L + L + + +VE +
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q +K+ A Q+ R+ QQ A+ +++ D +K E KA
Sbjct: 560 LKQKEQQLKE----VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 436 EMELRQMEVAQANR-----HMSLLTAFMPDSFL-RPGGDHDCVLVLLLMPRLICKAELIR 489
++E+ Q ++ AN S+ A + L R + + + +A++
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 490 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549
+ Q + E + +E+ + + L SL + + +L + + D +
Sbjct: 676 LELQLRSE-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR----AADALE 730
Query: 550 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ E+ A RSL + K+ +E + L + Q L H AE E
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEAHQAE-TEVLR 786
Query: 610 MQLADHI---KFTQSALDCMSVEVGRLRAFLQGGQ--EATDIALL---LRDLETSCSDIR 661
+LA+ + +S + + EV R + Q EA A+ L L+ C R
Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 662 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 721
Q ++ + ++ G ++ + L Q ++ L + +L + +QE A +L L
Sbjct: 847 QELQEAKEKVAGIES---HSELQISRQQNE-LAELHANLARALQQVQEKEVRAQKLADDL 902
Query: 722 AENEGLL------VAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE 775
+ + + VA LE L KA EQ ++ E +++ ++
Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQ----QETASRELVKEPAR----------AGDRQ 948
Query: 776 GEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEA 835
E+ E+ + + AAL+A +AE +G +LE + E S + EE +
Sbjct: 949 PEWLEEQQGRQFCSTQ---AALQAMEREAEQMGNELERLRAALME---SQGQQQEERGQQ 1002
Query: 836 NVRLSLLEKKLDSAAKDADERIEK-VQTRLE-ETQALLRKKEKEFEETMDALQADIDQLE 893
++ L ++ A AD +EK + LE Q L ++ EF +AL + + E
Sbjct: 1003 EREVARLTQERGRA--QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 894 AEKAELK--QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPG---QAPGSVP 948
+ EL + L + + +E LR + L +A +E++ + G +A G
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELR----QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116
Query: 949 GPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSE 1008
G ++ A+R +S+L E K + SL A + E
Sbjct: 1117 PTG---------PKLEALRAEVSKL--EQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 1009 LPAGALYRKTSQLLETLNQLST--------HTHVVDITRTSPAAKSPSAQLMEQVAQLKS 1060
G L K +L + + L++ T V D ++ K+ A+ ++ + S
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225
Query: 1061 LSDTVEKLKDEVLKETVSQRPG 1082
L ++E+ + +L V ++ G
Sbjct: 1226 LISSLEE-EVSILNRQVLEKEG 1246
Score = 85.9 bits (211), Expect = 2e-16
Identities = 192/926 (20%), Positives = 358/926 (38%), Gaps = 159/926 (17%)
Query: 71 GAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
G V L + +E L A L+ ++E L +R + +AKL H E+ Q+ S
Sbjct: 410 GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE--EEKQQLSSL 467
Query: 131 MQEQQADLQRRLKEARKEAKEALEAK-ERYMEEMADTADAIEMATLD------------- 176
+ + Q+ + L +A++E ++A +A R ++A E+ TL+
Sbjct: 468 ITDLQSSISN-LSQAKEELEQASQAHGARLTAQVASLTS--ELTTLNATIQQQDQELAGL 524
Query: 177 KEMAEER----AESLQQEVEA---LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ- 228
K+ A+E+ A++LQQ+ +A L+ +V++L++ L+ + +++E A+ Q
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584
Query: 229 ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284
EE+ A L++ ++ L + EK++ KL+ L Q+L+V + R+ Q ++Q
Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKLEIL----QQQLQVANEARDSAQTSVTQ 640
Query: 285 AESTIDELKEQVD--------AALGAEEMVEMLTDRNLNL---EEKVRELRETVGDLEAM 333
A+ EL +V+ A E + + L L ++K E + + +
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700
Query: 334 NEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL 393
E L+E+ + T+ L E+ A + E Q+ + E A+ + ++++++ L
Sbjct: 701 QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI---SELKAETRSLVEQHKRERKEL 757
Query: 394 QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANRHM 451
++ + + + ET + + AE A E E Q+ EVA
Sbjct: 758 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER- 816
Query: 452 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
+ + +L+ E K QE E E + G+
Sbjct: 817 -----------YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESH 862
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK---KVGSLYPEMSAHERSLDFL 568
+ Q+S L+ L A L R + + V K + +L +M+A + + L
Sbjct: 863 SELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919
Query: 569 IELLHK-DQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDC-- 625
L+ K + ET + E + + + QPE Q TQ+AL
Sbjct: 920 ETLVRKAGEQQETASRELVKEPARAGD--------RQPEWLEEQQGRQFCSTQAALQAME 971
Query: 626 -----MSVEVGRLRAFL---------QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRM 671
M E+ RLRA L + GQ+ ++A L ++ + +D+
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL----------- 1020
Query: 672 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
A A ++ + L + R + L LA+ GL A
Sbjct: 1021 ----ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 732 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 791
++EL E LRQ+ L + K G + P
Sbjct: 1077 IKEL-----------------EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
Query: 792 LRAAALRAEIT-----------DAEGLGLKLE-------DRETVIKELKKSLKIKGEE-- 831
+ ALRAE++ A+ L LE +R++ ++ L+ L+ K +E
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG 1179
Query: 832 -----LSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE--KEFEETMDA 884
L+ A L+ K+ +K DE +V +E + RK EE +
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE---RKNSLISSLEEEVSI 1236
Query: 885 LQADIDQLEAEKAELKQRLNSQSKRT 910
L + + E E ELK+ + ++S+++
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKS 1262
Score = 76.3 bits (186), Expect = 2e-13
Identities = 189/876 (21%), Positives = 334/876 (38%), Gaps = 114/876 (13%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS----KMQEQQAD 137
+E+ +RAQ L + L TL+ K A ++ LE + + QE S K + D
Sbjct: 889 QEKEVRAQ--KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946
Query: 138 LQRRLKEARK-----EAKEALEAKERYMEEMADTADAIEMATLDKE--MAEERAESLQQE 190
Q E ++ + AL+A ER E+M + + + A ++ + EER + ++E
Sbjct: 947 RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ-ERE 1005
Query: 191 VEALKERVDELTTDLEILKA---EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
V L + DL + KA E+E + + L + + A L++AL
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNA------LNEQRVEFATLQEALAHALTEK 1059
Query: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE--- 304
+ QE KL+ L + +ELE +RQ ++L+E+L++ E A G E
Sbjct: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119
Query: 305 -MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARV 362
+E L LE++ ++ +E LE E + R++ LE L+ QL+ +
Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEA-ERASRAERDSALETLQGQLEEKAQEL 1178
Query: 363 REAQKRVEAAQETVADYQQTIKKYR--------QLTAHLQDVNRE----LTNQQEASVER 410
+Q + +AQ +A ++ ++ + Q+ Q+ R+ + ++E S+
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238
Query: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 470
+Q E ++K K+ ++E R + + QA + A S LR
Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEER-LRLLQAETASNSARAAERSSALRE----- 1292
Query: 471 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQ 530
+ + +R++A+++ SEN LR Q A L L Q
Sbjct: 1293 -------------EVQSLREEAEKQRVASEN------LRQELTSQAERAEELGQELKAWQ 1333
Query: 531 ATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAI 590
+ E ALS ++ H + + ELL L + + E
Sbjct: 1334 EKFFQKEQALSTLQLE--------------HTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 591 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
++ + L EQ + L + Q E+G L Q E A L
Sbjct: 1380 RHREEL------EQSKQAAGGLRAELLRAQR-------ELGELIPLRQKVAEQERTAQQL 1426
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHL---------- 700
R + S ++ KK + + G+ G Q + LD +
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLL-AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485
Query: 701 ---TWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQ 757
T + V +E + A +L A+ EG V LEE E+ T E ++
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545
Query: 758 SCNILISTMNK-LATAMQEGEYDAER---PPSKPPPVELRAAALRAEITDAEGLGLKLED 813
+ ++K LA + Q + ++ ++ + A L+A++ + + + E
Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605
Query: 814 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE-RIEKVQTRLEETQALLR 872
K + K + + N L + L+ K+ E R E + E QA L
Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL- 1664
Query: 873 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
K KE E+T L A + LEA+ A Q+L K
Sbjct: 1665 -KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/356 (22%), Positives = 151/356 (42%), Gaps = 55/356 (15%)
Query: 85 GLRAQV----RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
GLRA++ R+L E L LR K AE + ++L K + K A+ R
Sbjct: 1394 GLRAELLRAQRELGE-LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 141 RLKEARKEAKEALE-----AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
L E ++ LE A+E+Y++E+A + AE R +Q+E ++
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAV----------RADAETRLAEVQREAQSTA 1502
Query: 196 ERVDELTTDLEILKAEIEEKGS----DGAASSYQLKQLE----EQNARLKDALVRMRDLS 247
++ +T E K ++ E+ + + Q++QLE EQ ++++ ++ D
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562
Query: 248 SSEKQEHVKLQKLMEK---KNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
+ K + KL+ + + QE + ++ Q LQ +LSQ E + K Q++ A +
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA---KT 1619
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
+ +N L+E++R L E ++ ELR + + G +++
Sbjct: 1620 HYDAKKQQNQELQEQLRSL------------------EQLQKENKELRAEAERLGHELQQ 1661
Query: 365 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPPPE 417
A + + A++T ++ AH R+L Q +A R+ Q P+
Sbjct: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717
Score = 65.5 bits (158), Expect = 3e-10
Identities = 82/399 (20%), Positives = 178/399 (44%), Gaps = 37/399 (9%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI-QLEQVQEWKSKMQEQQADLQ 139
+E E + + LEE++ L + E + + KEL++ + + E+ Q+ + +++ QA+
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277
Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
A + + E + EE A E + ERAE L QE++A +E+
Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF 1337
Query: 200 ELTTDLEILKAE-----------------IEEKGSDGAASSYQLKQLEEQNARLKDALVR 242
+ L L+ E ++ ++ AA+ + ++ EQ+ + L
Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG- 301
+ E E + L++ + ++ + + +R ++ E+LS + L E+ + LG
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGE 1456
Query: 302 ----AEEMVEMLTDRNLNLEEKVRELRETVGDLEA-MNEMNDELQENARETELELREQLD 356
+ +E+ D+ E+ V+EL D E + E+ E Q ARE E+ +
Sbjct: 1457 RANLGRQFLEVELDQ--AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK--- 1511
Query: 357 MAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
GA+V+ E Q+ E Q+ A +Q R+ T +++++++L + +AS +QQ+
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571
Query: 414 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
+ + E++ A+ ++ +L +++ + + +
Sbjct: 1572 LKA----VQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Score = 56.2 bits (134), Expect = 2e-07
Identities = 73/328 (22%), Positives = 133/328 (40%), Gaps = 73/328 (22%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----------------------KIQLEQ 123
LR +V + E + LR ++A +L L+K +++L+Q
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471
Query: 124 VQE-WKSKMQEQQADLQRRLKEARKEAK------------------EALEAKERYMEEMA 164
+E + ++ +AD + RL E ++EA+ + LE ++R+ EE
Sbjct: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER- 1530
Query: 165 DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 224
+ T E E ++VE L +++ + ++ + +++ + G S
Sbjct: 1531 ------QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
Query: 225 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284
+ ++L+ Q L+ L + + EH KLQ MEK + +QQ + LQE+L
Sbjct: 1585 EAQRLQAQLNELQAQLSQ-----KEQAAEHYKLQ--MEKAKTHYDAKKQQNQELQEQLRS 1637
Query: 285 AESTIDELKEQVDAA--LG------------AEEMVEMLTDRNLNLEEKVRELRETVGDL 330
E E KE A LG AE+ LT + +LE +V + + DL
Sbjct: 1638 LEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Query: 331 EAMNEMNDELQENARETELELREQLDMA 358
D L + E + + QLD++
Sbjct: 1698 GKFQVATDAL----KSREPQAKPQLDLS 1721
Score = 53.1 bits (126), Expect = 1e-06
Identities = 197/982 (20%), Positives = 370/982 (37%), Gaps = 134/982 (13%)
Query: 171 EMATLDKEMAEERAESLQQEVEALKER--VDELTTDLEILKAEIE------EKGSDGAAS 222
+M L K++A+ER+ + E+E + R + E + +++ I+ EK +
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 223 SYQLKQLEEQN----ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKN----------QEL 268
+L++L ++N RL + L + +DL + + Q K+ +L E+ L
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 269 EVVRQQRERLQEELSQAESTIDELKEQVDAALGA--------EEMVEMLTDRNLNLEEKV 320
+ ++ L EE S+A E + Q++ L A EE E+L + LEE +
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 321 RELRETVGDLEAMNEMNDELQ-ENARETELELREQLDMAGARVREAQ-KRVEAAQETVAD 378
+L++ E + D LQ E ++ L ARV + +R + + +A+
Sbjct: 395 SQLQDNPPQ-EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453
Query: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
++ +QL++ + D+ ++N +A E +Q + A + +
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 439 LRQMEVAQA-------NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
++Q + A + L G H V L L K + +++
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ---VEQLSSSLKQKEQQLKEV 570
Query: 492 AQEK--------FELSENCSERPGL---RGAAGEQL-SFAAGLVYSLSLLQATLHRYEHA 539
A+++ +L+ ER R AA +QL + L +LQ L A
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 540 LSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS- 598
V + E+S L +E ++Q + V L ++ Q +
Sbjct: 631 RDSAQTSV-TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
Query: 599 ----IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLE 654
+Q ++ L + +K T+ +L+ E R L+ Q + +L+
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLE---EEKRRAADALEEQQRC------ISELK 740
Query: 655 TSCSDIRQFCKKIRRRMPGTDA--PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAA 712
+ + K+ R+ + A G+ A L Q+ + H + +E+A
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEA------HQAETEVLRRELAE 791
Query: 713 AAAQLIAPLAENEGLL--VAALEELAFKASEQ---IYGTPSSSPYECLRQSC----NILI 763
A A +E E L+ VAA E ++ S+Q YG L++ C L
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRE-RYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850
Query: 764 STMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKK 823
K+A E R ++ + A ++ + E KL D + ++E
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE--- 907
Query: 824 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA--LLRKKEKEFEET 881
K S+ RL L +K + A + K R + Q L ++ ++F T
Sbjct: 908 ----KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963
Query: 882 MDALQA---DIDQLEAEKAELKQRL-NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 937
ALQA + +Q+ E L+ L SQ ++ E RG +A L Q+RG
Sbjct: 964 QAALQAMEREAEQMGNELERLRAALMESQGQQQEE--RGQQEREVARLT-------QERG 1014
Query: 938 AIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQH--ENSILKGAQMKASLASLPPL 995
QA ++ + L ++ R+ + LQ +++ + LA L L
Sbjct: 1015 R--AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 996 HVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTS-PAAKSPSAQLMEQ 1054
A++ ++ +L +T+ QL + S A+S +A E
Sbjct: 1073 EAAQI---------------KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117
Query: 1055 VA-QLKSLSDTVEKLKDEVLKE 1075
+L++L V KL+ + K+
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQ 1139
Score = 41.2 bits (95), Expect = 0.006
Identities = 197/985 (20%), Positives = 373/985 (37%), Gaps = 143/985 (14%)
Query: 216 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 275
GS + L+ + Q RLK L R + E + +KL+ +K+ ++ +++Q+
Sbjct: 199 GSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258
Query: 276 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA--- 332
+RL + ++E +Q + L +E+ E L D+N +L ++ E + DL+
Sbjct: 259 DRL--------ALLNE--KQAASPLEPKEL-EELRDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 333 --------MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 384
++E N +L RE L++ D E K + E A ++ +
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367
Query: 385 KYRQLTAHLQDVNR----ELTNQQEASVERQQQPPPETFD----------FKIKFAETKA 430
Q L++ N +L+ +E + Q PP E + K + A A
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427
Query: 431 HAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 490
+ ++ + +E + + LL R + + + L+ L I
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAE-------RGHFEEEKQQLSSLITDL---QSSISN 477
Query: 491 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 550
+Q K EL E S+ G R A A L L+ L AT+ + + L+ +K
Sbjct: 478 LSQAKEEL-EQASQAHGARLTAQ-----VASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 551 VGSLYPEMSAHERS---LDFLIELL------HKDQLDETVNVEPLTKAIKYYQHLYSIHL 601
L + E++ L +E L + QL E + T+ H +
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR----QDHAQQLAT 587
Query: 602 AEQPEDCTMQLADHIKFTQSALDC-MSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDI 660
A + + +++ D AL+ + ++ L+ LQ EA D A +TS +
Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA------QTSVTQA 641
Query: 661 RQFCKKIRRRMPGTDAPGIPA------ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAA 714
++ ++ R++ A A A A ++ L ++ T V QE
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 715 AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQ 774
QL A L E+ + +LEE +A++ + C+ + + T + + +
Sbjct: 702 EQLQA-LKESLKVTKGSLEEEKRRAADAL-----EEQQRCISE---LKAETRSLVEQHKR 752
Query: 775 E-GEYDAERPPSKPPPVELR---------AAALRAEITDAEGLGLKLEDR-ETVIKEL-- 821
E E + ER K L+ LR E+ +A E E ++KE+
Sbjct: 753 ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812
Query: 822 -----KKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEK 876
+ S + + + + +L L+++ + A ++ E EKV ++ + +++
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQN 872
Query: 877 EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGI--AGEEQ 934
E E L + Q++ EK Q+L + T++ +A L + + AGE+Q
Sbjct: 873 ELAELHANLARALQQVQ-EKEVRAQKL-ADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
Query: 935 Q---RGAIPGQAPGSVPGPGLVKDSP-----LLLQQISAMRLHISQLQHENSILKGAQMK 986
+ R + A P +++ + AM Q+ +E L+ A M+
Sbjct: 931 ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALME 990
Query: 987 A-----SLASLPPLHVAKLSHEGPGSE----LPAGALYRKTSQLLETLN----QLSTHTH 1033
+ VA+L+ E ++ L A +L LN + +T
Sbjct: 991 SQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE 1050
Query: 1034 VVDITRTSPAAKSPSAQLME-----QVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTD 1088
+ T K + Q+ +L+ L TV++LK+++ K+ G+ ++
Sbjct: 1051 ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 1089 FA-----TFPSSAFLRA---KEEQQ 1105
A T P LRA K EQQ
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQ 1135
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 96.3 bits (238), Expect = 1e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 81 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205
Query: 436 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 483 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 538 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 595 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473
Query: 711 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
A A A+ E + L +A E A +A E++ T E
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587
Query: 815 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 872 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 929 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 988 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
+ +LS+E A QL +L + H ++ T
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Score = 80.5 bits (197), Expect = 8e-15
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 96 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 155 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933
Query: 215 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 275 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052
Query: 323 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105
Query: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 437 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206
Query: 497 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
EL+E + + + A L L +L EH + V +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263
Query: 553 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 608 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
+Q K S L + E L+ L EA +D L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 652 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430
Query: 712 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539
Query: 831 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 890 DQLEAE-KAELKQR-LNSQSKRTIEG 913
+ E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624
Score = 79.3 bits (194), Expect = 2e-14
Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198
Query: 196 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 238 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 298 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 400 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491
Query: 452 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
L L K EL R K E+ + S + +
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580
Query: 572 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 632 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 690 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 750 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+
Sbjct: 1809 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1861
Query: 870 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 909
RK ++++E + A + QL+ E E QR+N+ ++
Sbjct: 1862 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737
Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793
Query: 265 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847
Query: 320 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1891
Query: 380 QQTIKKYRQLTAHLQDVNRELTNQQEAS 407
+ +++ A+ + + REL E++
Sbjct: 1892 -----ESQRINANRRKLQRELDEATESN 1914
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 185 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 245 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 305 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643
Query: 472 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 529 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 583 VEPLTKAIK 591
+E ++ ++
Sbjct: 1752 MEAMSDRVR 1760
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)
Query: 67 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 122
L + A+ K+ L+AQ++D + +LE R R E A KE EK LE
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 123 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 162
Q+QE ++ +QADL++ + A ++ K LEA+ +EE
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 163 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 193
M +D + AT L E+A ER+ ES +Q++E
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 194 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1863
Query: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
+ ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1919
Query: 313 NLN-LEEKVRELRET 326
+N L+ K+R ET
Sbjct: 1920 EVNALKSKLRRGNET 1934
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 96.3 bits (238), Expect = 1e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 81 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212
Query: 436 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 483 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 538 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 595 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480
Query: 711 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
A A A+ E + L +A E A +A E++ T E
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594
Query: 815 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 872 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 929 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 988 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
+ +LS+E A QL +L + H ++ T
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Score = 80.5 bits (197), Expect = 8e-15
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 96 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 155 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940
Query: 215 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 275 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059
Query: 323 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112
Query: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 437 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213
Query: 497 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
EL+E + + + A L L +L EH + V +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270
Query: 553 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 608 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
+Q K S L + E L+ L EA +D L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 652 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437
Query: 712 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546
Query: 831 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 890 DQLEAE-KAELKQR-LNSQSKRTIEG 913
+ E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631
Score = 79.3 bits (194), Expect = 2e-14
Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205
Query: 196 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 238 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 298 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 400 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498
Query: 452 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
L L K EL R K E+ + S + +
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587
Query: 572 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 632 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 690 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 750 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+
Sbjct: 1816 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1868
Query: 870 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 909
RK ++++E + A + QL+ E E QR+N+ ++
Sbjct: 1869 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744
Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800
Query: 265 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854
Query: 320 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1898
Query: 380 QQTIKKYRQLTAHLQDVNRELTNQQEAS 407
+ +++ A+ + + REL E++
Sbjct: 1899 -----ESQRINANRRKLQRELDEATESN 1921
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 185 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 245 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 305 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650
Query: 472 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 529 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 583 VEPLTKAIK 591
+E ++ ++
Sbjct: 1759 MEAMSDRVR 1767
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%)
Query: 67 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 122
L + A+ K+ L+AQ++D + +LE R R E A KE EK LE
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 123 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 162
Q+QE ++ +QADL++ + A ++ K LEA+ +EE
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 163 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 193
M +D + AT L E+A ER+ ES +Q++E
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 194 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1870
Query: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
+ ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1926
Query: 313 NLN-LEEKVRELRET 326
+N L+ K+R ET
Sbjct: 1927 EVNALKSKLRRGNET 1941
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 96.3 bits (238), Expect = 1e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 81 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212
Query: 436 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 483 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 538 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 595 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480
Query: 711 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
A A A+ E + L +A E A +A E++ T E
Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594
Query: 815 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 872 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 929 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 988 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
+ +LS+E A QL +L + H ++ T
Sbjct: 1770 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Score = 85.1 bits (209), Expect = 3e-16
Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205
Query: 196 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 238 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 298 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 400 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498
Query: 452 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
L L K EL R K E+ + S + +
Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587
Query: 572 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 632 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 690 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 750 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815
Query: 810 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 853
K + + T+ I +L++ ++ + E A L +KKL A+
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 854 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 910
E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ +
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1934
Query: 911 IEGLRGPPP 919
LRGPPP
Sbjct: 1935 ---LRGPPP 1940
Score = 81.3 bits (199), Expect = 5e-15
Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744
Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800
Query: 265 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854
Query: 320 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 380 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
+K ++ + N + + A + + PPP+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1941
Score = 80.5 bits (197), Expect = 8e-15
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 96 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 155 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940
Query: 215 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 275 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059
Query: 323 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112
Query: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 437 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213
Query: 497 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
EL+E + + + A L L +L EH + V +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270
Query: 553 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 608 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
+Q K S L + E L+ L EA +D L+
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 652 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437
Query: 712 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546
Query: 831 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 890 DQLEAE-KAELKQR-LNSQSKRTIEG 913
+ E E + E KQR L + +K+ +EG
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 185 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 245 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 305 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650
Query: 472 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 529 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 583 VEPLTKAIK 591
+E ++ ++
Sbjct: 1759 MEAMSDRVR 1767
Score = 33.5 bits (75), Expect = 1.2
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 72 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 131
A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1903
Query: 132 QEQQADLQRRLKEARKEAKEAL 153
+ LQR L EA E+ EA+
Sbjct: 1904 NANRRKLQRELDEA-TESNEAM 1924
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 96.3 bits (238), Expect = 1e-19
Identities = 214/1061 (20%), Positives = 423/1061 (39%), Gaps = 141/1061 (13%)
Query: 81 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 135
KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
++ ++L+ + ++L+ I + ++ A + K L + + + + + E++
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
+K+REL + DL+ + + A + + +L E+L+ + +E ++
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
A Q+ K Q L+ E T EA V+ +Q HA+A+
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205
Query: 436 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 482
E +L Q + A+AN + T ++ L + +H + + L
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 483 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 537
K E R + +K +N E L A G+ + A + S LQ T +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 538 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 594
Q ++V K+ L E ++ + LD E+ K L+ T+N++ K
Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 595 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 650
++ E+ + + L + +A D + RL+ QE D+ +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
DL+ + KK R+ D LL K+++ A ++
Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473
Query: 711 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 754
A A A+ E + L +A E A +A E++ T E
Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 814
L +S L + M ++ T ++E E + + +E+ AL+ + L + E
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587
Query: 815 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 871
E ++L++ L EL + + +L +KKL+ KD + + + EE L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 872 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 928
RK + K+F+ ++ +A D++ A E N + +++E +A
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKE-----NEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 929 IAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKA 987
+ ++ + + S+ G ++D L+ +I+ + + + Q + KA
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 988 SLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTS 1041
+ +LS+E A QL +L + H ++ T
Sbjct: 1763 T------QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 1042 PAAKSPSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1079
A ++ AQL EQV A+ K + K KD+ LKE + Q
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Score = 85.1 bits (209), Expect = 3e-16
Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 135
+K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+
Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198
Query: 196 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 237
++ V+ELT LE K +E++ +D A L Q +E + +L+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 238 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 297
+ ++ S ++ +L + K E+E V + + + + L Q+
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 298 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
+E+++ T + LN+ K+R+L E L+ + E ++N L QL
Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 399
+ ++++ VEA +E +Q+ I+ Q L L D+ +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 400 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 451
L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491
Query: 452 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 511
L L K EL R K E+ + S + +
Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
E L + ++ L E L Q + D L E++ F +L
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580
Query: 572 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
+D+ +E + ++ H Y L ++ + + A K D
Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 632 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 689
++ + ++ + ++D + D R +I + A + A L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 690 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
RK L E A++ L + + L A + +L + E+ +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 750 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
S + +R++ N+LAT A++ S +E + LR+++ + EG +
Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808
Query: 810 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 853
K + + T+ I +L++ ++ + E A L +KKL A+
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 854 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 910
E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ +
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1927
Query: 911 IEGLRGPPP 919
LRGPPP
Sbjct: 1928 ---LRGPPP 1933
Score = 81.3 bits (199), Expect = 5e-15
Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE
Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 204
K+AK + E++A A + A L+K E+AEE A SL AL++ L
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737
Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
+ L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793
Query: 265 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847
Query: 320 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 379
++L+E + +E +M + + +EQ + ARV++ ++++E A+E
Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 380 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
+K ++ + N + + A + + PPP+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1934
Score = 80.5 bits (197), Expect = 8e-15
Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%)
Query: 96 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 154
KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 155 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 214
K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE
Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933
Query: 215 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 274
+ G + K++ +Q L++ L + E V + ++K E+ V+ Q
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 275 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 322
+L +E E I + L E+ + A E M+ L R L EEK R+
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052
Query: 323 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
R+ GD +E +LQ E +++L + + E Q + + +A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105
Query: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 436
+KK R+L H+ D+ +L +++ A E+Q++ E + E + A +
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 437 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 496
ELR A+ + +++L + + H+ + E+ +K AQ
Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206
Query: 497 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 552
EL+E + + + A L L +L EH + V +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263
Query: 553 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 607
L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q
Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 608 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 651
+Q K S L + E L+ L EA +D L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 652 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 711
D ++ + + K+ ++ + A A+ D L + L QE+
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430
Query: 712 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 770
L +N+ LV+ LE+ K + + + SS Y R A
Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
++ +A + +E L+AE+ D L +D + EL+KS +
Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539
Query: 831 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 889
++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ +
Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 890 DQLEAE-KAELKQR-LNSQSKRTIEG 913
+ E E + E KQR L + +K+ +EG
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624
Score = 75.5 bits (184), Expect = 3e-13
Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 124
V L S + E RA++ D KL+ T L AE KA KL K++ QL+
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 184
QE + Q+ ++ +L++ +E + + ME + I + ++++
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 185 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
+ VEAL+E ++E L + EEK + +L+++ L L R
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 245 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 305 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 351
+E T++ L E + V EL ++ LE M EM +L+E E EL+
Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
E + V + + ++ A +Q +K RQL L + EL + ER+
Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
Q+ A A K +E +L+ +E+ DS ++ G +
Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643
Query: 472 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 528
+ +L + QAQ K EL + + R + A E A L L
Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 529 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 582
LQ L E A Q ++ + L +S +R L+ I L ++ +E N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 583 VEPLTKAIK 591
+E ++ ++
Sbjct: 1752 MEAMSDRVR 1760
Score = 33.5 bits (75), Expect = 1.2
Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 72 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 131
A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1896
Query: 132 QEQQADLQRRLKEARKEAKEAL 153
+ LQR L EA E+ EA+
Sbjct: 1897 NANRRKLQRELDEA-TESNEAM 1917
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 94.7 bits (234), Expect = 4e-19
Identities = 176/853 (20%), Positives = 340/853 (39%), Gaps = 153/853 (17%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQA 136
K+ L +Q+ +L+E LE+ R R + + + + ELE K +LE + + QE ++
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALK 195
++ + +K +E + E ++EM + A+E E + +L++ + L+
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 196 ERVDELTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDAL--------VRMR 244
EL ++++L K + E K A +L+ + R++ L V +
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 245 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 304
+++ Q K KL + + ++ +E LQEE Q S +LK+ D E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
+E + NLE+++ L V D++ E + E A E + +L++ L+ R
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR--- 1400
Query: 365 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS--VERQQ----QPPPET 418
+E VA Y + K +L L D+ +L +Q++++ +E++Q Q E
Sbjct: 1401 -------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 419 FDFKIKFAETK--AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL 476
K+AE + A A+A E E + + +A+A
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARA----------------------------- 1484
Query: 477 LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRY 536
L + KAEL R Q + E+ + S + + + E L +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE------------------LEKS 1526
Query: 537 EHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHL 596
+ AL Q ++ ++ L E+ A E D + +E +A+K
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATE---------------DAKLRLEVNLQAMKAQFER 1571
Query: 597 YSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS 656
EQ E+ QL ++ ++ L+ + + R+ ++ ++ L +DLE
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELE----DERKQRSMAVAARKKLEMDL--KDLEAH 1625
Query: 657 CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQ 716
+ + +++ A + DC + L A +E+ A A +
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQ---------------MKDCMRELDDTRASREEILAQAKE 1670
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 776
L E ++ EELA A+E+ E + N + K A A++E
Sbjct: 1671 NEKKLKSMEAEMIQLQEELA--AAERAKRQAQQERDELADEIAN----SSGKGALALEEK 1724
Query: 777 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 836
+E R A L E+ + +G + DR L +AN
Sbjct: 1725 R-----------RLEARIAQLEEELEEEQGNTELINDR-----------------LKKAN 1756
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA-LQADIDQLEAE 895
+++ + L+ A ++ E + +LE L+ K +E E T+ + +A I LEA+
Sbjct: 1757 LQIDQINTDLNLERSHA-QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 896 KAELKQRLNSQSK 908
A+L+++L++++K
Sbjct: 1816 IAQLEEQLDNETK 1828
Score = 91.3 bits (225), Expect = 5e-18
Identities = 245/1120 (21%), Positives = 459/1120 (40%), Gaps = 158/1120 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQ 132
V PL S++EE + A+ EE+L +R K+ + +L E+E + QL K+Q
Sbjct: 834 VKPLLQVSRQEEEMMAK----EEELVKVREKQLAAENRLTEMETLQSQL-----MAEKLQ 884
Query: 133 -EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191
++Q + L +E + L AK++ +EE+ +A E EER + LQ E
Sbjct: 885 LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA------RVEEEEERCQHLQAEK 938
Query: 192 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 241
+ +++ + EL LE ++ ++ + + +LK+LEE+ L+D
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 242 -RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300
R+ + +++ +E K + L + KN+ ++ ERL+ E Q +
Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE------------- 1045
Query: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
E+ L + +L +++ EL+ + +L+ +E + A E Q +MA
Sbjct: 1046 -LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 361 RVREAQKRVEAAQETV----ADYQQTIKKYRQLTAHLQDVNRELTN-------QQEASVE 409
++RE + ++ QE + A + K+ R L L+ + EL + QQE +
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 410 RQQQPP--PETFDFKIKFAET------KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 461
R+Q+ +T + + K E + H++A+E Q+E Q R + L
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE--QTKRVKANLEKAKQTL 1222
Query: 462 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAG 521
G + V VLL K + K+ + + +L E L+ E
Sbjct: 1223 ENERGELANEVKVLLQ-----GKGDSEHKRKKVEAQLQE-------LQVKFNEGERVRTE 1270
Query: 522 LVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETV 581
L ++ LQ L LSQ K L + SA E L ELL ++ + +
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSD----SKSSKLTKDFSALESQLQDTQELLQEEN-RQKL 1325
Query: 582 NVEPLTKAIKYYQHLYSIHLAEQPE----------DCTMQLADHIKFTQSALDCMSV--E 629
++ K ++ ++ + L E+ E Q+AD K + ++ C+ E
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 630 VGR-LRAFLQGGQEATDIALLLRD-LETSCSDIRQFCKKIRRRMPGTDAPGIPAA-LAFG 686
V R L+ L+G + + + D LE + + ++Q ++ + D A L
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442
Query: 687 PQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGL-LVAALEE-LAFKASEQIY 744
+ D LL K ++ A ++ A A A+ E + L L ALEE + KA +
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKAELERL 1498
Query: 745 GTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELRA---AALRA 799
+ E L S + + ++++L + + E E ++ + EL+A A LR
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 800 EIT----------DAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL---LEKKL 846
E+ D +G + E+++ K+L + ++ EL + + S+ KKL
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKK---KQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Query: 847 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETM---DALQADIDQLEAEKAELKQRL 903
+ KD + I+ +E LRK + + ++ M D +A +++ A+ E +++L
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675
Query: 904 NSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQI 963
S I+ +A +Q+R + + S G G L L++
Sbjct: 1676 KSMEAEMIQ-----LQEELAAAERAKRQAQQERDELADEIANS-SGKG-----ALALEEK 1724
Query: 964 SAMRLHISQLQHE------NSILKGAQMKASLASLPPLHV---AKLSHEGPGSELPAGAL 1014
+ I+QL+ E N+ L ++K + + ++ + SH +E L
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH-AQKNENARQQL 1783
Query: 1015 YRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQV--------AQLKSLSDTVE 1066
R+ +L L ++ T + A ++ AQL EQ+ A K + T +
Sbjct: 1784 ERQNKELKVKLQEME-GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 1067 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQD 1106
KLKD VL + +R A D A S+ + K + ++
Sbjct: 1843 KLKD-VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881
Score = 75.1 bits (183), Expect = 4e-13
Identities = 96/365 (26%), Positives = 170/365 (46%), Gaps = 51/365 (13%)
Query: 64 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE- 122
T L+ A+ E E L Q R ++E L + + + ELEK K LE
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 123 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
QV+E K++++E + +LQ A ++AK LE + M+ + ++ D++ E+
Sbjct: 1533 QVEEMKTQLEELEDELQ-----ATEDAKLRLEVNLQAMKAQFER----DLQGRDEQSEEK 1583
Query: 183 RAESLQQEVEALKERVDE-------------LTTDLEILKAEIE--EKGSDGAASSYQLK 227
+ + ++Q E E DE L DL+ L+A I+ K D A +K
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA-----IK 1638
Query: 228 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 287
QL + A++KD + + D +S ++E + K EKK + +E + +LQEEL+ AE
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRAS-REEILAQAKENEKKLKSMEA---EMIQLQEELAAAER 1694
Query: 288 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 347
+ +++ D A+E+ L LEEK R L + LE +EL+E T
Sbjct: 1695 AKRQAQQERDEL--ADEIANSSGKGALALEEK-RRLEARIAQLE------EELEEEQGNT 1745
Query: 348 ELELREQLDMAGARVREAQKRVEA----AQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 403
EL + ++L A ++ + + AQ+ QQ ++ ++L LQ++ + ++
Sbjct: 1746 EL-INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 404 QEASV 408
+AS+
Sbjct: 1805 YKASI 1809
Score = 75.1 bits (183), Expect = 4e-13
Identities = 93/352 (26%), Positives = 171/352 (48%), Gaps = 47/352 (13%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKA-------KLKELEKH-----KIQLEQVQEWK 128
++++ L QVR++E +LE R +R+ A LK+LE H K + E +++ +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 129 SKMQEQQADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKEM-AEERAES 186
K+Q Q D R L + R +E L +AKE E+ + +A EM L +E+ A ERA+
Sbjct: 1642 -KLQAQMKDCMRELDDTRASREEILAQAKEN--EKKLKSMEA-EMIQLQEELAAAERAK- 1696
Query: 187 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQ-------NARLKDA 239
+Q + E DE+ +EEK A + ++LEE+ N RLK A
Sbjct: 1697 -RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 240 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
+++ +++ E QK E Q+LE +Q + L+ +L + E T+ + A
Sbjct: 1756 NLQIDQINTDLNLERSHAQK-NENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 300 LGAE--EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
L A+ ++ E L + + +++R T L+ + D+ + NA + ++Q D
Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE----QYKDQADK 1867
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD-------VNRELTN 402
A R+++ ++++E A+E + Q+ R+L L+D +NRE+++
Sbjct: 1868 ASTRLKQLKRQLEEAEE---EAQRANASRRKLQRELEDATETADAMNREVSS 1916
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/299 (21%), Positives = 128/299 (42%), Gaps = 40/299 (13%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
K+ L+AQ++D +L+ R R E A+ KE EK M+ + LQ
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----------KSMEAEMIQLQE 1687
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA------- 193
L A + ++A + ++ +E+A+++ +A +K E R L++E+E
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
+ +R+ + ++ + ++ + S + +QLE QN LK L M S+ +
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 254 HV--------KLQKLMEKKNQELEV----VRQQRERLQEELSQAES---TIDELKEQVDA 298
+ +L++ ++ + +E + VR+ ++L++ L Q + ++ K+Q D
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Query: 299 ALGA--------EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 349
A EE E N + + REL + +AMN L+ R +L
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
Score = 42.0 bits (97), Expect = 0.003
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 24/123 (19%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQ 135
L + +KE + QVR E+KL K L +++ + EQ ++ K +
Sbjct: 1823 LDNETKERQAACKQVRRTEKKL----------KDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 136 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 195
L+R+L+EA +EA+ A ++ + E+ D A E A+++ +EV +LK
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELED--------------ATETADAMNREVSSLK 1918
Query: 196 ERV 198
++
Sbjct: 1919 NKL 1921
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.7 bits (234), Expect = 4e-19
Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 130
+KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K +
Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 131 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 185
M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108
Query: 186 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 227
LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 228 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 280
+++ A + RDL + Q L +K ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 281 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282
Query: 337 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 395
LQ + E +L E+ + R Q + +E ++ IK L LQ
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 396 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
+ + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401
Query: 447 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 502
A H+ + A E +++ Q + E
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437
Query: 503 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 559
ER AA +Q +F L + T HA + S + +G+ L+ +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492
Query: 560 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 615
A+E SLD L E L ++ + + LT+ I K L I + E C +Q A
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549
Query: 616 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
+ A + E G+ LR L+ Q +++ + + + +++ +I M T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 675 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
+ A + L + L AA+ + +G+L
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 735 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 792
L A ++ E + + + N+L + + +L +++ E + +
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 793 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 844
R L + T KLE + E +++E + + + + +++A + L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 845 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 898
+ D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827
Query: 899 LKQRLNSQSKRTIEGLRG 916
L+ + S+ KR E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845
Score = 89.4 bits (220), Expect = 2e-17
Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
+++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
L + +K EI++ S+ S LE+ L+D L +L S E+++ + L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279
Query: 261 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 310
++ ++ E ++E L +LS+ + I+ELK Q++ + A+ +
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 311 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 358
+ + L E+ E +E+ +L+ A+++ N E+ + +A + EL E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 359 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 418
R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458
Query: 419 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 471
++K K ET A +A + E R + ++ A + L ++ D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 472 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 529
+ + I + E I+KQ QEK EL E L G+ L L S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 530 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 583
+ + + Q + + V S+ + A RS + I L K ++++ +N
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638
Query: 584 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 633
+A++ Y++ I HL + ED QLA + + + E+ L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694
Query: 634 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 693
RA L+ + + IA E D + + + + + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729
Query: 694 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 753
++ +K L ++ +Q ++ E A+ + A A E +S+ E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 754 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 810
++++ T+ L + E E A + K +E R L E+ + +
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 811 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
L E +KE L + EE + +RL L KL + K + E+ + +
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 869 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
A RK + E EE + +ADI + + K +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931
Score = 88.6 bits (218), Expect = 3e-17
Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 179
+ K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 180 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 226
++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 227 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 264
++LEE + RL++A + M RDL + Q L +K
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 265 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 317
++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 318 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 378 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 427
++ IK L LQ + + +QE+ E Q+ + E ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382
Query: 428 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 480
T A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 481 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 531
C A +++ +K E + C E L + E S L Y SL Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 532 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 581
TL R L Q D+ +++ + ++ + L +E E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 582 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 635
+ + + + +AE+ E+ +HI+ +S + E+ RL+
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 694
++G L ++E + + + R T GI + D L
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669
Query: 695 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 752
D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
+ L LI+T KL T + + + + E + E +A + ITDA + +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776
Query: 813 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 861
+ L++ K + + + +RL E+ KL++ ++ + +E Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 862 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 910
R E LRK E+ +E + D +D+L+A+ K++ +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Score = 82.0 bits (201), Expect = 3e-15
Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)
Query: 102 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 161
LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E
Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 162 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 207
+AD + I++ KE+ E E E + E+ A K +++ EL D++
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 208 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 267
L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012
Query: 268 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 326
L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 327 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 383
+ D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 384 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
+ R A + +L+ + E ER ++ T + K + R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185
Query: 444 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 501
A Q + L DS G D + + K +L +++++ K E+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237
Query: 502 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 561
S + A G L LS L++ + ++ D+ + G L E
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293
Query: 562 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 621
R LD ++ V L++ + + +Q E+ QL + IK +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334
Query: 622 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 678
AL + LR + QE+ A L R L + +++ Q+ K TDA
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385
Query: 679 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 738
Q ++ L + +K L + +E A A L + + L +E+L
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 739 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 798
E +C L + E + E ++ + A +L
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 799 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 858
E+ + + D+ +K K+L+ + +L+E +L+ K ++
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 859 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 916 GPPPSGIATLVSGIAGEEQQRG 937
+ I + I +++ G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626
Score = 82.0 bits (201), Expect = 3e-15
Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)
Query: 88 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E
Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933
Query: 134 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
+ ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 254 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 304
+ L++ K +L++ + ++++L E+L + E I L+ ++ + ALG
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
+ L++K++EL+ + +LE E + A + +L +L+ R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 365 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
A ++E ++ A++Q+ + + T + L + SV +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 421 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 475
K K + K+ K ME+ + V++A ++ + + D
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262
Query: 476 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 531
+EL K+ +++ +++ ++R L+ +GE QL LV LS QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 532 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 589
+ E Q ++ K +L + + D L E ++Q + L+KA
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 590 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 645
+ ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430
Query: 646 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 705
+ L+ D+E + + KK R F +++ C + + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475
Query: 706 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 765
+E + +L + A EE S E L++ L
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514
Query: 766 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 825
++ L + EG VE L+A + +AE LE E I ++ L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571
Query: 826 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 885
+ SE + +++ ++++D ++ +E +Q+ L + E DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618
Query: 886 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
+ ++E + E++ +LN ++ E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)
Query: 87 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 139
R +R +E TL ++ D +LK +L + +IQL ++ + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
LK+ + +AL ++E E++A M E RA LQ E+E L+ ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
+ +I + E+ + +S +++ L QN L +++K+ + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 315
+ + L+ R E+ ++ ++ A +ELK++ D + E M + + D L
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 316 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
L+E + +RE G++E+ + N E + R+ E ++E
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858
Query: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 413
+ E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Query: 414 PPPETFDFKIKFAETKAHAKAIEME 438
+ ++K E H K I E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941
Score = 54.7 bits (130), Expect = 5e-07
Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719
Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 190
+ + + K++ +++ +E + AEE+ AE L++E
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 191 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 245
+E +K+ +++ DL++ E E+ G KQ+++ AR+++ +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830
Query: 246 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 305
SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Query: 306 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353
E ++ NL K R+L+ +LE E D + + ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 128 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 183 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
++++Q V+ L+ R+DE +I K E + +G S Q + E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 237 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 289
K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 290 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 320
EL+E + A AE V L ++ + KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 41.2 bits (95), Expect = 0.006
Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 128
L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 129 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
++Q+ LQ ++K +++A+EA E + + +E A EERA+ +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920
Query: 189 QEVEALKERVDELTT 203
+V L+ + E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.7 bits (234), Expect = 4e-19
Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 130
+KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K +
Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 131 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 185
M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A
Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108
Query: 186 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 227
LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 228 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 280
+++ A + RDL + Q L +K ++++ +++ +++L++
Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 281 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282
Query: 337 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 395
LQ + E +L E+ + R Q + +E ++ IK L LQ
Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342
Query: 396 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
+ + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401
Query: 447 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 502
A H+ + A E +++ Q + E
Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437
Query: 503 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 559
ER AA +Q +F L + T HA + S + +G+ L+ +
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492
Query: 560 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 615
A+E SLD L E L ++ + + LT+ I K L I + E C +Q A
Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549
Query: 616 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 674
+ A + E G+ LR L+ Q +++ + + + +++ +I M T
Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 675 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 734
+ A + L + L AA+ + +G+L
Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 735 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 792
L A ++ E + + + N+L + + +L +++ E + +
Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717
Query: 793 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 844
R L + T KLE + E +++E + + + + +++A + L+K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 845 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 898
+ D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827
Query: 899 LKQRLNSQSKRTIEGLRG 916
L+ + S+ KR E ++G
Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845
Score = 89.4 bits (220), Expect = 2e-17
Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
+++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ +
Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
L + +K EI++ S+ S LE+ L+D L +L S E+++ + L
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279
Query: 261 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 310
++ ++ E ++E L +LS+ + I+ELK Q++ + A+ +
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 311 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 358
+ + L E+ E +E+ +L+ A+++ N E+ + +A + EL E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399
Query: 359 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 418
R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458
Query: 419 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 471
++K K ET A +A + E R + ++ A + L ++ D
Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518
Query: 472 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 529
+ + I + E I+KQ QEK EL E L G+ L L S +
Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 530 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 583
+ + + Q + + V S+ + A RS + I L K ++++ +N
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638
Query: 584 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 633
+A++ Y++ I HL + ED QLA + + + E+ L
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694
Query: 634 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 693
RA L+ + + IA E D + + + + + +L
Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729
Query: 694 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 753
++ +K L ++ +Q ++ E A+ + A A E +S+ E
Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786
Query: 754 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 810
++++ T+ L + E E A + K +E R L E+ + +
Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 811 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
L E +KE L + EE + +RL L KL + K + E+ + +
Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 869 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 902
A RK + E EE + +ADI + + K +K R
Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931
Score = 88.6 bits (218), Expect = 3e-17
Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 125 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 179
+ K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086
Query: 180 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 226
++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 227 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 264
++LEE + RL++A + M RDL + Q L +K
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 265 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 317
++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 318 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 378 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 427
++ IK L LQ + + +QE+ E Q+ + E ++ K+ E
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382
Query: 428 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 480
T A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 481 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 531
C A +++ +K E + C E L + E S L Y SL Q
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 532 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 581
TL R L Q D+ +++ + ++ + L +E E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 582 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 635
+ + + + +AE+ E+ +HI+ +S + E+ RL+
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 694
++G L ++E + + + R T GI + D L
Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669
Query: 695 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 752
D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
+ L LI+T KL T + + + + E + E +A + ITDA + +L+
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776
Query: 813 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 861
+ L++ K + + + +RL E+ KL++ ++ + +E Q
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 862 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 910
R E LRK E+ +E + D +D+L+A+ K++ +++
Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Score = 82.0 bits (201), Expect = 3e-15
Identities = 165/862 (19%), Positives = 351/862 (40%), Gaps = 107/862 (12%)
Query: 102 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 161
LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E
Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 162 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 207
+AD + I++ KE+ E E E + E+ A K +++ EL D++
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962
Query: 208 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 267
L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q
Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012
Query: 268 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 326
L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+
Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 327 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 383
+ D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I
Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 384 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
+ R A + +L+ + E ER ++ T + K + R +E
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185
Query: 444 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 501
A Q + L DS G D + + K +L +++++ K E+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237
Query: 502 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 561
S + A G L LS L++ + ++ D+ + G L E
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293
Query: 562 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 621
R LD ++ V L++ + + +Q E+ QL + IK +
Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334
Query: 622 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 678
AL + LR + QE+ A L R L + +++ Q+ K TDA
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385
Query: 679 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 738
Q ++ L + +K L + +E A A L + + L +E+L
Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 739 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 798
E +C L + E + E ++ + A +L
Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 799 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 858
E+ + + D+ +K K+L+ + +L+E +L+ K ++
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 859 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 916 GPPPSGIATLVSGIAGEEQQRG 937
+ I + I +++ G
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEG 1626
Score = 82.0 bits (201), Expect = 3e-15
Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%)
Query: 88 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 133
A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E
Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933
Query: 134 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 193
+ ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 254 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 304
+ L++ K +L++ + ++++L E+L + E I L+ ++ + ALG
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
+ L++K++EL+ + +LE E + A + +L +L+ R+ E
Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 365 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 420
A ++E ++ A++Q+ + + T + L + SV +
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 421 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 475
K K + K+ K ME+ + V++A ++ + + D
Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262
Query: 476 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 531
+EL K+ +++ +++ ++R L+ +GE QL LV LS QA
Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 532 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 589
+ E Q ++ K +L + + D L E ++Q + L+KA
Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 590 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 645
+ ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430
Query: 646 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 705
+ L+ D+E + + KK R F +++ C + + A
Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475
Query: 706 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 765
+E + +L + A EE S E L++ L
Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514
Query: 766 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 825
++ L + EG VE L+A + +AE LE E I ++ L
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571
Query: 826 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 885
+ SE + +++ ++++D ++ +E +Q+ L + E DA+
Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618
Query: 886 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
+ ++E + E++ +LN ++ E LR
Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%)
Query: 87 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 139
R +R +E TL ++ D +LK +L + +IQL ++ + Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
LK+ + +AL ++E E++A M E RA LQ E+E L+ ++
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
+ +I + E+ + +S +++ L QN L +++K+ + +
Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 315
+ + L+ R E+ ++ ++ A +ELK++ D + E M + + D L
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 316 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 360
L+E + +RE G++E+ + N E + R+ E ++E
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858
Query: 361 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 413
+ E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918
Query: 414 PPPETFDFKIKFAETKAHAKAIEME 438
+ ++K E H K I E
Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941
Score = 54.7 bits (130), Expect = 5e-07
Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719
Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 190
+ + + K++ +++ +E + AEE+ AE L++E
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 191 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 245
+E +K+ +++ DL++ E E+ G KQ+++ AR+++ +
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830
Query: 246 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 305
SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Query: 306 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353
E ++ NL K R+L+ +LE E D + + ++ RE
Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 128 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 183 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
++++Q V+ L+ R+DE +I K E + +G S Q + E
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 237 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 289
K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++
Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906
Query: 290 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 320
EL+E + A AE V L ++ + KV
Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 41.2 bits (95), Expect = 0.006
Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 128
L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867
Query: 129 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
++Q+ LQ ++K +++A+EA E + + +E A EERA+ +
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920
Query: 189 QEVEALKERVDELTT 203
+V L+ + E+ T
Sbjct: 1921 SQVNKLRVKSREVHT 1935
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.4 bits (233), Expect = 6e-19
Identities = 178/905 (19%), Positives = 370/905 (40%), Gaps = 131/905 (14%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLETL-----RLKRAEDKAKLKELEKHKIQLEQVQEW 127
+ PL ++ E+ + D E E L R K E+K EK+ +QL+ E
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899
Query: 128 KSKMQEQQA----------------DLQRRLKEARKEAKEALEAKERYMEEMADTA---- 167
++ M ++ +L RL+E +E L AK+R +E+ +
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEE-EEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 168 DAIEMATL----DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 223
D +E+ +K E + ++L +E+ AL+E + +LT + + L+ ++ D
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 224 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-------VRQQRE 276
++ L + NA+L+ + EK+ L++ K +L++ + ++
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 277 RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 336
+++E+L + E + +L+ ++D +E V +L ++K++EL+ + +LE E
Sbjct: 1079 QIEEKLKKKEFELSQLQAKID-----DEQV-----HSLQFQKKIKELQARIEELEEEIEA 1128
Query: 337 NDELQENARETELELREQLDMAGARVREA----QKRVEAAQETVADYQQTIKKYRQLTAH 392
L+ + +L +L+ R+ EA ++E ++ A++Q+ + + T
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 393 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
+ L +Q SV + K K + K+ K ME+ ++
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK--------MEIDDMASNIE 1240
Query: 453 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAA 512
L S + + C V + K E +Q Q +L+ + G
Sbjct: 1241 AL------SKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIHDLNMQKARLQTQNGEL 1291
Query: 513 GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELL 572
++ L+ L+ + L + L + + K ++ + + D L E
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351
Query: 573 HKDQLDETVNVEPLTKA---IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALD-- 624
++Q + L+KA + ++ Y +I E+ E+ +LA ++ + +
Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 625 ---CMSVEVGRLRAFLQGGQEATDIALLLRDLE---TSCSDI----RQFCKKI---RRRM 671
C S+E + R LQG ++ L+RDLE T+C+ + R F K + ++++
Sbjct: 1412 NSKCASLEKTKQR--LQG-----EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 672 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 731
+ A + AA +S L R VV L+ + EN+
Sbjct: 1465 DESQAE-LEAAQKESRSLSTELFKMRNAYEEVVDQLETLR----------RENKN----- 1508
Query: 732 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 791
L+E +EQI T + + ++ ++ + L A++E E E SK V+
Sbjct: 1509 LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566
Query: 792 LRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---EANVR----LSLLEK 844
L + +++E L K+ +++ I++LK++ + E L +A +R L+K
Sbjct: 1567 LELSQVKSE------LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620
Query: 845 KLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLN 904
K++ + + ++ ++ ETQ LR + + +++ Q +D +LK++L
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS----QLHLDDALRSNEDLKEQLA 1676
Query: 905 SQSKR 909
+R
Sbjct: 1677 IVERR 1681
Score = 93.6 bits (231), Expect = 1e-18
Identities = 193/967 (19%), Positives = 398/967 (41%), Gaps = 165/967 (17%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLR---LKRAEDKAKLKELEKHKIQLEQVQEWK---- 128
L KE+ +V++L E++ L K ++K L+E + + QV+E K
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 129 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-------------- 170
+K+++Q DL+ L++ +K + AK + ++ + ++I
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084
Query: 171 -----EMATLDKEMAEERAESLQ--QEVEALKERVDELTTDLEI---LKAEIEEKGSDGA 220
E++ L ++ +E+ SLQ ++++ L+ R++EL ++E L+A+IE++ SD A
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144
Query: 221 ASSYQLKQLEEQNARLKDALVRM------------RDLSSSEKQEHVKLQKLMEKKNQEL 268
++ + E+ + A + M RDL + Q L +K+ +
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204
Query: 269 EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 328
+ +Q + LQ + E ELK ++D +E L+ N+E R + +
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEID---DMASNIEALSKSKSNIERTCRTVEDQFS 1261
Query: 329 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR- 387
+++A +E +L + + L+ Q RV E + + ++ Q +++ +
Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321
Query: 388 ----------------QLTAHLQDVNRE-LTNQQEASVERQQ---QPPPETFDFKIKFAE 427
Q + H D+ RE +QEA E Q+ + E ++ K+ E
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY-E 1380
Query: 428 TKAHAKAIEMELRQMEVAQANRHMSLLT-------AFMPDSFLRPGGDHDCVLVLLLMPR 480
T A + E+E + ++AQ + T A + + R G+ + ++ L
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
Query: 481 LICKAELIRKQ-------AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATL 533
C A L +KQ A+ K +L E+ +E L A E S + L + + +
Sbjct: 1441 TAC-ATLDKKQRNFDKVLAEWKQKLDESQAE---LEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 534 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSL---DFLIELLHKDQLDETVNVEPLTKAI 590
+ E L + + ++ +++ L +++ ++L + +L+ +++ D V +E + ++
Sbjct: 1497 DQLE-TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 591 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALL 649
++ E+ + +QL + +S LD +E + + Q A +
Sbjct: 1556 EH----------EESKILRVQL--ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 650 LRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQE 709
+ D E R +++++M G D + L + + + +KHL V L++
Sbjct: 1604 VLDAEIRS---RNDALRLKKKMEG-DLNEMEIQLGHSNR---QMAETQKHLRTVQGQLKD 1656
Query: 710 VAAAA----------AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC 759
+ +A + GLL+ LEE+ A EQ T S E L S
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV-ALEQTERTRRLSEQELLDASD 1715
Query: 760 NI---------LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLK 810
+ LI+T KL + + + + E + E +A + ITDA + +
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKA---KKAITDAAMMAEE 1772
Query: 811 L---EDRETVIKELKKSLK-----------------IKG--EELSEANVRLSLLEKKLDS 848
L +D ++ +KK+L+ +KG +++ + R+ LE +LD
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 849 AAKDADERIE---KVQTRLEETQALLRKKEKEF---EETMDALQADIDQLEAEKAELKQR 902
K E ++ K + +++E + K ++ +D LQA + + + E +++
Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 903 LNSQSKR 909
N+Q R
Sbjct: 1893 ANTQLSR 1899
Score = 56.6 bits (135), Expect = 1e-07
Identities = 69/326 (21%), Positives = 138/326 (42%), Gaps = 38/326 (11%)
Query: 92 DLEEKLETLRLKRAEDKAKLKELE----KHKIQLEQVQEWKSKMQEQQADLQRRLKEA-- 145
++ + + LRLK+ + L E+E Q+ + Q+ +Q Q D Q L +A
Sbjct: 1608 EIRSRNDALRLKKKME-GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 146 -RKEAKEALEAKER----YMEEMADTADAIEMATLDKEMAE-------ERAESLQQEVEA 193
++ KE L ER +EE+ + A+E + ++E +R + L + +
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
L +L D+ +AE+E + + + K+ A + + L + +D S+ ++
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 254 HVKLQKLMEKKNQELEVVRQ--------QRERLQEELSQAESTID-ELKEQVDAALGAEE 304
L++ ++ L+ Q Q ++L+ + + E+ +D E K +A GA +
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846
Query: 305 MVEMLTDRNLNLEE---KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGAR 361
+ + EE + L++ V L+A +++ R+ E E EQ + +R
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQA------KVKSYKRQAE-EAEEQANTQLSR 1899
Query: 362 VREAQKRVEAAQETVADYQQTIKKYR 387
R Q +E A E + + K R
Sbjct: 1900 CRRVQHELEEAAERADIAESQVNKLR 1925
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/275 (20%), Positives = 123/275 (44%), Gaps = 44/275 (16%)
Query: 90 VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEA 149
+R E+ E L + + L+ELE+ K+ LEQ + + +++ D R++ +
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 150 KEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE------VE 192
+ K++ ++A +E + + AEE+ AE L++E +E
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL------------ 240
+K+ +++ DL+ E E+ G Q+++LE + L++ L
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKK--QIQKLENRVRELENELDVEQKRGAEALK 1842
Query: 241 ------VRMRDLSSSEKQEH---VKLQKLMEKKNQELEVVRQQRERLQE----ELSQAES 287
++++++ +++H ++LQ L++K +++ ++Q E +E +LS+
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902
Query: 288 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE 322
EL+E + A AE V L ++ ++ + E
Sbjct: 1903 VQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 36.6 bits (83), Expect = 0.14
Identities = 34/156 (21%), Positives = 71/156 (45%), Gaps = 49/156 (31%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLL----------EKKLDS----------- 848
+LE+ + +++ +++ ++ +EL +A+ R+ LL +KKL++
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 849 ---AAKDADERIEKVQT----------RLEETQALLRKKEKEFEETMDALQADIDQ---- 891
+++A+E+ +K T + ++T A L + +K E+T+ LQ +D+
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 892 -----------LEAEKAELKQRLNSQSKRTIEGLRG 916
LE EL+ L+ + KR E L+G
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843
Score = 32.7 bits (73), Expect = 2.0
Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 3/103 (2%)
Query: 813 DRETVIKELKKSLKIKGEELSEANVRLS---LLEKKLDSAAKDADERIEKVQTRLEETQA 869
D E +++++ LK K ELS+ ++ + + K+ RIE+++ +E
Sbjct: 1072 DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
Query: 870 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
L K EK+ + L+ ++LE ++ KR E
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 94.0 bits (232), Expect = 7e-19
Identities = 99/400 (24%), Positives = 192/400 (48%), Gaps = 48/400 (12%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQ 134
L ++++ L +++R LEE+ +L+ ++ E++ K LEK + L+ Q+ + K K+ +
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 135 QADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMA--TLDKEMAE-----ERAESL 187
++ L+EA+K+ + EA + +EE A D +E L +E+ + + +
Sbjct: 1384 LGTIE-SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 188 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR-LKDALVRMRDL 246
+E +++ D+L + + + A E+ A + + + AR L++AL +
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502
Query: 247 SSSEKQEHVKLQKLMEKKN------QELEVVRQQRERLQEEL-SQAESTIDELKEQVDAA 299
KQ ++ LM K+ ELE ++ E+ EE+ +Q E DEL+ DA
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 300 LGAEEMVEM--------LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351
L E ++ L R+ EEK R L + V +LEA E+ DE ++ A +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA--ELEDERKQRALAVASKK 1620
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
+ ++D+ ++ + ++EAA + + IK+ R+L A ++D REL +EA R
Sbjct: 1621 KMEIDL-----KDLEAQIEAANKA---RDEVIKQLRKLQAQMKDYQREL---EEARASRD 1669
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANR 449
+ + E++ K++E E+ Q+ E+A + R
Sbjct: 1670 --------EIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Score = 93.6 bits (231), Expect = 1e-18
Identities = 177/882 (20%), Positives = 353/882 (40%), Gaps = 148/882 (16%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
L+AQ+ +L+E E+ + R + + + + ELE K +LE + + QE + ++
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 142 LKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
+ E +K +E + E +++M A A+E + E A+ +L++ + L+ E
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 201 LTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
L ++++L KAE E K A +L + RL+ L ++ KL
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA----------EKASKL 1285
Query: 258 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 317
Q ++ + LE ++ + ++ + ES + + +E+++ T + LNL
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD----------TQELLQEETRQKLNLS 1335
Query: 318 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV----------REAQK 367
++R+L E L+ E +E ++N + L L+ QL +V EA+K
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 368 RV--------EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE--ASVERQQ----Q 413
++ + +E Y + K +L L D+ +L +Q++ +++E++Q Q
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 414 PPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 471
E ++AE +A A+A E E + + +A+A
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARA------------------------ 1491
Query: 472 VLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQA 531
L L K E R+ Q + ++ + S + + E L + ++
Sbjct: 1492 -----LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 532 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIK 591
L E L Q + D L E++ F +L +D+ +E E IK
Sbjct: 1547 QLEELEDEL-QATED-----AKLRLEVNMQAMKAQFERDLQTRDEQNE----EKKRLLIK 1596
Query: 592 YYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLL 650
+ L L ++ + + +A K M +++ L A ++ +A D + L
Sbjct: 1597 QVREL-EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 651 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 710
R L+ D ++ ++ R A ++ + K L+ +
Sbjct: 1648 RKLQAQMKDYQRELEEAR---------------ASRDEIFAQSKESEKK-------LKSL 1685
Query: 711 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLA 770
A QL LA +E A +E A E T S+S L L + + +L
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEI---TNSASGKSALLDEKRRLEARIAQLE 1742
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
++E + + E + L+ L AE+ K ++ ++ K LK K +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 831 EL------------SEANVRLSLLEKKLDSAAKD---ADERIEKVQTRLEETQALL---R 872
EL S ++ LE++L+ AK+ A++ + + + +L+E + R
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862
Query: 873 KKEKEFEETMDALQADIDQL--EAEKAELKQRLNSQSKRTIE 912
+ +++E M+ A + QL + E+AE + + S+R ++
Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Score = 90.9 bits (224), Expect = 6e-18
Identities = 215/1082 (19%), Positives = 426/1082 (39%), Gaps = 181/1082 (16%)
Query: 73 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-KHKIQLEQVQEWKSKM 131
V PL +++EE L+A+ +E+L ++ K+ + + +L+E+E KH+ LE+ +
Sbjct: 841 VKPLLQVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE-----KNI 891
Query: 132 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191
+Q + L +E + L AK++ +EE+ ++ E EER + LQ E
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES------RVEEEEERNQILQNEK 945
Query: 192 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 241
+ ++ + +L L+ + ++ + + ++K++EE+ L+D
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 242 -RMRDLSSSEKQEHVKLQKLM--------------------EKKNQELEVVRQQRE---- 276
R+ + SS +E K + L EK QELE +++ +
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 277 RLQEELSQAESTIDELKEQV----DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
LQ+++++ ++ IDELK Q+ + GA + T N + VREL+ + +L+
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
E + A + + +L E+L+ + +E +T A Q+ K Q A
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELE-------ALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 393 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 452
L+ E T EA ++ +Q HA A+E Q+E QA R +
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQ----------------RHATALEELSEQLE--QAKRFKA 1220
Query: 453 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK-QAQEKFELSENCSERPGLRGA 511
L + G + D L C+ +++++ +A+ + + + ++ L
Sbjct: 1221 NLEK------NKQGLETD-------NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 512 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 571
E L S LQ L L + KK + ++ E L EL
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAE----KKGIKFAKDAASLESQLQDTQEL 1323
Query: 572 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 631
L +++ + +N+ + ++ ++ E+ E+ L + QS L +V
Sbjct: 1324 L-QEETRQKLNLSSRIRQLEEEKNSLQ-EQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 632 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFC------KKIRRRMPGTDAPGIPAALAF 685
++ +EA LL+D E + + +K + R+ + + L
Sbjct: 1382 DDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ-QELDDLTVDLDH 1438
Query: 686 GPQVSDTLLDCRKHLTWVVAVLQEVAAA------AAQLIAPLAENEGLLVAALEELAFKA 739
QV+ L +K ++A + ++A A+ A E + L +A E A +A
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 740 SEQIYGTPSSSPYEC----------------LRQSCNILISTMNKLATAMQEGEYDAERP 783
E+ + L +S L + ++ T ++E E + +
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 784 PSKPPPVELRAAALRAEI-TDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 842
+E+ A++A+ D + + E+++ ++ + + L+ + E+ +
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 843 EKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLEAEKAEL 899
+KK++ KD + +IE +E LRK + K+++ ++ +A D++ A+ E
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 900 KQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLL 959
+++L S ++ +A+ EQ+R + + S G L
Sbjct: 1679 EKKLKSLEAEILQ-----LQEELASSERARRHAEQERDELADEITNSASG------KSAL 1727
Query: 960 LQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTS 1019
L + + I+QL+ E L E EL +RKT+
Sbjct: 1728 LDEKRRLEARIAQLEEE-----------------------LEEEQSNMEL-LNDRFRKTT 1763
Query: 1020 QLLETLN-QLSTHTHVVDITRTSPAAKSPSA--QLMEQVAQLKSLSDTVEKLKDEVLKET 1076
++TLN +L+ S A KS +A QL Q +LK+ +E K T
Sbjct: 1764 LQVDTLNAELA--------AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815
Query: 1077 VS 1078
+S
Sbjct: 1816 IS 1817
Score = 85.9 bits (211), Expect = 2e-16
Identities = 185/977 (18%), Positives = 402/977 (41%), Gaps = 103/977 (10%)
Query: 82 EEEGLRAQVRDLEEKLET-------LRLKRAEDKAKLKELEKHKIQLEQVQ----EWKSK 130
E++ ++A ++DLEE+L+ L+L++ +AK+K++E+ + LE + K
Sbjct: 944 EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003
Query: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
M+++ A+ +L E ++AK + + + ++D + ++ ++ E+ L E
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 191 VEALKERVDELTTDLEILKAEIEEKGSD--GAASSYQLKQLEEQNA-----RLKDALVRM 243
L++++ EL ++ LK ++ +K + GA + + L + NA L+ + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 244 RDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRE------RLQEEL-SQAESTIDELKEQV 296
++ SEK K +K ++ELE ++ + E Q+EL ++ E + ELK+ +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 297 DAAL-GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDE-LQENARETELELREQ 354
+ E ++ + R+ E++ E E +A E N + L+ + +E E++
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV- 1242
Query: 355 LDMAGARVREAQKRVEA-AQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
L A +K+++A QE A + + +L + EL N E +++
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302
Query: 414 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP-----DSFLRPGGD 468
IKFA+ A ++ + +++ + + ++L + +S +
Sbjct: 1303 G--------IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 469 HDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLS- 527
+ L L +++L A K ++ ++ L A + L A L L
Sbjct: 1355 EEEARKNLEKQVLALQSQL----ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 528 ------LLQATLHRYEHALSQCSVDV---------YKKVGSLYPEMSAHERSLDFLIELL 572
L+ T +R + L +VD+ +K + ++ A E+S I
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISAR 1466
Query: 573 HKDQLD--ETVNVEPLTKAIKYYQHLY-SIHLAEQPEDCTMQLADHIKFTQSALDCMSVE 629
+ ++ D E E TKA+ + L ++ E+ E QL ++ S+ D +
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 630 VGRLRAFLQG-GQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQ 688
V L + Q+ ++ L +LE D Q + + R+ + + A Q
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELE----DELQATEDAKLRLE-VNMQAMKAQFERDLQ 1581
Query: 689 VSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS 748
D + +K L ++++V A+L + L VA+ +++ +
Sbjct: 1582 TRDEQNEEKKRL-----LIKQVRELEAEL-EDERKQRALAVASKKKMEIDLKDL------ 1629
Query: 749 SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLG 808
+ E ++ + +I + KL M++ + + E + + ++ ++ E
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 809 LKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 868
L+L++ + ++ + + +EL++ + + L + + RI +++ LEE Q
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 869 ALLRKKEKEFEET---MDALQADI--DQLEAEKA----ELKQRLNSQSKRTIEGLRGPPP 919
+ + F +T +D L A++ ++ A+K+ + +R N + K ++ L G
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809
Query: 920 SGIATLVSGIAG-----EEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQL- 973
S +S + EEQ +A + K + Q+ R H Q
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK 1869
Query: 974 -QHENSILKGAQMKASL 989
Q E + + Q+K L
Sbjct: 1870 EQMEKANARMKQLKRQL 1886
Score = 78.2 bits (191), Expect = 4e-14
Identities = 85/345 (24%), Positives = 152/345 (44%), Gaps = 26/345 (7%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
K+ L+AQ++D + +LE R R E A+ KE EK +L+ ++ ++QE+ A +R
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK---KLKSLEAEILQLQEELASSER 1701
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA--EERAESLQQEVEALKERV 198
+ A +E E A E +A E L+ +A EE E Q +E L +R
Sbjct: 1702 ARRHAEQERDEL--ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK-L 257
+ T ++ L AE+ + S S +QLE QN LK L + S+ + + L
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 258 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV-DAALGAEEMVEMLTDRNLNL 316
+ + + ++LE ++R + + + E + E+ QV D A++ E + N +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 317 EEKVRELRETVGDLEAMNEMNDELQ---ENARETELELREQLDMAGARVREAQKRVEAAQ 373
++ R+L E + N +LQ ++A E L ++ R+R
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------ 1933
Query: 374 ETVADYQQTIKKYRQLTAHLQDVNRELTN---QQEASVERQQQPP 415
+ + RQL HL+ + EL++ + + S + QPP
Sbjct: 1934 ---ISFSSSRSGRRQL--HLEGASLELSDDDTESKTSDVNETQPP 1973
Score = 77.0 bits (188), Expect = 9e-14
Identities = 99/442 (22%), Positives = 191/442 (43%), Gaps = 87/442 (19%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQ 139
K L R LE+++E +R + E + +L+ E K++LE +Q K++ + DLQ
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQ 1581
Query: 140 RRLKEARKEAKEALEAKERYME-EMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
R E +E K L + R +E E+ D +A K+ E + L+ ++EA +
Sbjct: 1582 TR-DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 199 DELTTDLEILKAEI--------------EEKGSDGAASSYQLKQLEEQNARLKDALVRMR 244
DE+ L L+A++ +E + S +LK LE + +L++ L
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 245 DLSSSEKQEHVKL-----------QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 293
+QE +L L+++K + + Q E L+EE S E D +
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 294 E---QVD---AALGAEEMVEMLTD--------RNLNLEEKVREL--------RETVGDLE 331
+ QVD A L AE +D +N L+ K++EL + T+ LE
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 332 A-MNEMNDELQENARE----------TELEL-----------------REQLDMAGARVR 363
A + ++ ++L++ A+E TE +L +EQ++ A AR++
Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 364 EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKI 423
+ ++++E A+E + +K ++ + N L+ + R ++ P I
Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------I 1934
Query: 424 KFAETKAHAKAIEMELRQMEVA 445
F+ +++ + + +E +E++
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS 1956
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 93.6 bits (231), Expect = 1e-18
Identities = 184/884 (20%), Positives = 340/884 (38%), Gaps = 109/884 (12%)
Query: 77 PSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQA 136
PS E L + + E L ++ E + KEL+ K L+Q ++ + ++ Q
Sbjct: 387 PSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVM 446
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK- 195
+LQ +LK + AKE ++++ +T + +E K+ EE+ ++E+ ALK
Sbjct: 447 ELQNKLKHVQGPEP----AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKG 502
Query: 196 ---ERVDELTTDLEILKAEIEE------KGSDGAASSYQLKQLEEQNARLKDALVRMRDL 246
E V ++E ++ + + + A + + + E Q ALVR
Sbjct: 503 ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKM---SALVRGLQR 559
Query: 247 SSSEKQEHVKLQKLMEKKN--------QELEVVRQQRERLQEELSQAESTIDELKEQVDA 298
E E + M +KN QEL +R ++E ++EEL + + EQ A
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619
Query: 299 ALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELR-EQLDM 357
+ G VE+L L +E+++EL+ + E+ R+ ELE + L +
Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQ--------AERQSQEVAGRHRDRELEKQLAVLRV 671
Query: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
R RE +++ Q+T+ +Q ++ + + + + Q+ A+VE + E
Sbjct: 672 EADRGRELEEQNLQLQKTLQQLRQDCEEASK-AKMVAEAEATVLGQRRAAVETTLRETQE 730
Query: 418 TFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLL 477
D E + +E +L++ L GG+ +
Sbjct: 731 END------EFRRRILGLEQQLKETR------------------GLVDGGE-------AV 759
Query: 478 MPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE----QLSFAAGLVYSLSLLQATL 533
RL K + + + Q+ E E G AA +L A + L Q TL
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 534 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 593
+R + + + L + +R++D L + L K D ++ L ++ Y
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 594 QHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDL 653
+ +A+ A + T L + E+ RLR LQ Q D A L ++L
Sbjct: 880 KEKARREVADAQRQ-AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938
Query: 654 ETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAA 713
+ +R+ G + + D K L V+ L+
Sbjct: 939 -------------LAQRLQGLEQEA-----ENKKRSQDDRARQLKGLEEKVSRLETELDE 980
Query: 714 AAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC---NILISTMNKLA 770
+ L + +++L +E + + EC + S N + T +
Sbjct: 981 EKNTVELLTDRVNRGRDQVDQL---RTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037
Query: 771 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 830
Q+ + S+ ++ R A E T + KLE + +KEL ++ + +
Sbjct: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK---VKELSIQIEDERQ 1094
Query: 831 ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADID 890
+++ +LSL K L +A+E IE RL+ + +++ +E E + LQA I
Sbjct: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIE----RLDGLRKKAQREVEEQHEVNEQLQARIK 1150
Query: 891 QLEAEKAELKQRLNSQSKRTIEGLRGP-------PPSGIATLVS 927
LE + R ++S EGL PS IA+L++
Sbjct: 1151 SLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLT 1194
Score = 84.3 bits (207), Expect = 6e-16
Identities = 89/346 (25%), Positives = 159/346 (45%), Gaps = 44/346 (12%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK----HKIQLEQVQ----EW 127
L K+ E LR +LEE+ L R D+ KELEK K L+Q+Q ++
Sbjct: 823 LEEEGKQREVLRRGKAELEEQKRLL--DRTVDRLN-KELEKIGEDSKQALQQLQAQLEDY 879
Query: 128 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM-------ATLDKEMA 180
K K + + AD QR+ K+ EA++ R +E+ A++ A LDKE+
Sbjct: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939
Query: 181 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 240
+R + L+QE E K D+ L+ L+ ++ ++ ++ L ++ R +D +
Sbjct: 940 AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQV 999
Query: 241 VRMRDLSSSEK--QEHVKLQKL-MEKKNQELEVVRQQRERLQE---ELSQAESTIDELKE 294
++R E+ ++ ++ K+ +E++N++L+ E Q+ LSQ ES L+E
Sbjct: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059
Query: 295 QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQ 354
++ A E +L N LE KV+EL ++ DE Q + +Q
Sbjct: 1060 RLQAE---EREKTVLQSTNRKLERKVKELSI---------QIEDERQH--------VNDQ 1099
Query: 355 LDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL 400
D RV+ +++V+ A+E + KK ++ +VN +L
Sbjct: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
Score = 63.5 bits (153), Expect = 1e-09
Identities = 85/386 (22%), Positives = 169/386 (43%), Gaps = 65/386 (16%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLR-------LKRAEDKAKLKELEKHKIQLEQVQEWK 128
L +E + R ++ LE++L+ R A + KL+ LE K QLE+
Sbjct: 725 LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN-A 783
Query: 129 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 188
S+ +E +R EAR E EA R +E A+E +E+ L+
Sbjct: 784 SQEEEGSLAAAKRALEARLE--EAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841
Query: 189 QEVEALKERVDELTTDLE-----------ILKAEIEEK------------------GSDG 219
++ L VD L +LE L+A++E+ S+
Sbjct: 842 EQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEA 901
Query: 220 AASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK-LMEKKNQELEVVRQQRERL 278
+S L +L+++ RL+ AL +S +++ +L K L+ ++ Q LE + ++R
Sbjct: 902 EKTSGGLSRLQDEIQRLRQAL-----QASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956
Query: 279 QEELSQAESTIDELKEQVDAALGAEE-MVEMLTDRNLNLEEKVRELRETV-------GDL 330
Q++ ++ ++E +++ L E+ VE+LTDR ++V +LR + DL
Sbjct: 957 QDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL 1016
Query: 331 EAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETV--ADYQQTI----- 383
E ++++ E Q +T L E A + + + + + QE + + ++T+
Sbjct: 1017 EC-DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTN 1075
Query: 384 ----KKYRQLTAHLQDVNRELTNQQE 405
+K ++L+ ++D + + +Q++
Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKD 1101
Score = 40.4 bits (93), Expect = 0.010
Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 36/197 (18%)
Query: 762 LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKEL 821
L+ T +L E + + +E + A LR E G +LE++ +++
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR----GRELEEQNLQLQKT 689
Query: 822 KKSLKIKGEELSEANV-----------RLSLLEKKLDSAAKDADE---RIEKVQTRLEET 867
+ L+ EE S+A + R + +E L ++ DE RI ++ +L+ET
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET 749
Query: 868 QALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ---------SKRTIEGLRGPP 918
+ L+ E D LQ +LEAEK +L++ LN+ +KR +E
Sbjct: 750 RGLVDGGEAVEARLRDKLQ----RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
Query: 919 PSGIATLVSGIAGEEQQ 935
G+A L G+EQQ
Sbjct: 806 QRGLARL-----GQEQQ 817
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 91.7 bits (226), Expect = 4e-18
Identities = 84/374 (22%), Positives = 180/374 (48%), Gaps = 16/374 (4%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 139
E + L +++ + KL+ +++ E +L + ++ K+ Q E++QEW+ K+QEQ+ +
Sbjct: 327 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 384
Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
R +E +E +E + +E M E + E +KE R E + E E ++
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
E + E ++ E EEK + Q K+ +EQ A++ ++R+ +++ K+ +
Sbjct: 445 EKMHEQEKIR-EQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQEEKMWR 502
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE---QVDAALGAEEMVEMLTDRNLNL 316
EK +++ ++ +++ + QEE+ + E I E +E Q + EE + ++
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 317 EEKVRELRETVGDLE----AMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
EEK+ + E + + E E E +E RE E ++REQ +M + + ++ E
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622
Query: 373 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ---QQPPPETFDFKIKFAETK 429
E Q+ +K R+ +++ +++ Q+E E++ Q+ + ++ + K E +
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682
Query: 430 AHAKAIEMELRQME 443
+ E ++R+ E
Sbjct: 683 EKMQEQEEKMRRQE 696
Score = 89.0 bits (219), Expect = 2e-17
Identities = 70/367 (19%), Positives = 170/367 (46%), Gaps = 19/367 (5%)
Query: 89 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKE 148
++++ EEK++ K E + K++E E+ + E++ K + +Q ++ +E +
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428
Query: 149 AKEALEAKERYMEEMADTADAIEMATLDKEMAEE----RAESLQQEVEALKERVDELTTD 204
+E + KE + E+ + E +E +E R + +QE EA R +E +
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488
Query: 205 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 264
E E EEK ++ +++ E+ R ++ R +QE + QK EK
Sbjct: 489 QEEKIREQEEKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIREQEEIWRQK--EKI 545
Query: 265 NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELR 324
+++ E +R+Q E++ + + ++++EQ + EE + EEK+RE
Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR-------EQEEKIREQE 598
Query: 325 ETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 384
E + + E M + +E E E E++ ++R ++++ ++ + + ++ I+
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 385 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 444
+ ++ +Q+ ++ Q+E E++++ + + K++ E K + + + ++ ++
Sbjct: 659 EQEEM---MQEQEEKMWEQEEKMCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKM 713
Query: 445 AQANRHM 451
+ H+
Sbjct: 714 QEHQEHL 720
Score = 83.2 bits (204), Expect = 1e-15
Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 46/381 (12%)
Query: 68 TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 127
TS G P + A R+LE ++ T+R+ + K +L+ + L Q
Sbjct: 161 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 213
Query: 128 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 173
+++ + DL RL ++ K E ++AL A +RY+EE+ DA+ +
Sbjct: 214 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273
Query: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 217
T+ E +E+ LQ++++ ++ E+ +++ LK AE + G
Sbjct: 274 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 333
Query: 218 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 272
+ + S +L+ E+N L + L + ++ ++E + K+Q+ EK ++ E +R
Sbjct: 334 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 273 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
+Q E+++ + ++++ Q + EE + + EEK+REL E + + E
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
+ E ++ QE + E E R++ + A++ ++++ +E + + ++ + + +
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 393 LQDVNRELTNQQEASVERQQQ 413
+ + E Q++ + RQ++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEE 530
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/322 (23%), Positives = 163/322 (50%), Gaps = 29/322 (9%)
Query: 81 KEEEGLRAQVRDLEEKLETLRL--KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
++EE +R Q + EK E +R ++ ++ K++E E+ + + E+++E + K QEQ+A +
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKM 479
Query: 139 QRRLKEARKEAKEALEAKERY--MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
R+ ++ R++ ++ E +E+ EE + I ++E +E+ E +QE E ++E
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQE-EKIRE 534
Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 256
+ +E+ E + E EEK +++ EE+ R ++ +M D +++ K
Sbjct: 535 Q-EEIWRQKEKIH-EQEEK----------IRKQEEKMWRQEE---KMHDQEEKIREQEEK 579
Query: 257 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 316
+ + EK ++ E +R+Q E+++E+ + +++ EQ + EE ++ ++
Sbjct: 580 VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 317 EEKVRE----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
EEK+RE +RE + EM E +E E E ++ EQ + + + +++ E
Sbjct: 640 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 699
Query: 373 QETVADYQQTIKKYRQLTAHLQ 394
E +Q +K ++ HL+
Sbjct: 700 WEQEVRLRQQEEKMQEHQEHLE 721
Score = 79.0 bits (193), Expect = 2e-14
Identities = 68/299 (22%), Positives = 150/299 (50%), Gaps = 29/299 (9%)
Query: 89 QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 136
++R+LEEK+ E +++ E+K K++E EK + Q E+++E + K++EQ+
Sbjct: 439 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 498
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 193
+ R+ ++ ++ K E K + EEM + I E KE E+ E ++++ E
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
+ + +++ E ++ + E+ Q +++ EQ ++++ ++ ++
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 254 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
K+ + EK ++ E +R+Q E+++E+ + ++++EQ EEM++ ++
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKM 671
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
EEK+ E E + + E E +E E E+ LR+Q + +++E Q+ +EAA
Sbjct: 672 WEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHLEAA 723
Score = 75.1 bits (183), Expect = 4e-13
Identities = 75/340 (22%), Positives = 158/340 (46%), Gaps = 22/340 (6%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRA---EDKAKLKELEKHKIQLEQ-VQEWKSKMQEQQA 136
++EE +R Q + EK E +R + E + K++ E+ + E+ ++E + KM EQ+
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE- 451
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
+ R +E +++ +E + +E+ E+ A E +E E+ E + ++ E + E
Sbjct: 452 --KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 197 ----RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
R +E + E + + EEK + Q +++ EQ +++ +M
Sbjct: 510 QEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 312
+ K+++ EK ++ E +R+Q E+++E+ ++++EQ + EE + ++
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQ-------EEKIREQEEMTQEQEEKMGEQEEK 621
Query: 313 NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 372
EEK++E E + E E ++ RE E ++REQ +M + + ++ E
Sbjct: 622 MCEQEEKMQEQEE---KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678
Query: 373 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
E Q+ +K R+ + + L Q+E E Q+
Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 68.2 bits (165), Expect = 4e-11
Identities = 48/225 (21%), Positives = 115/225 (51%), Gaps = 7/225 (3%)
Query: 81 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
++EE + Q +R+ E++ E + R E+K ++E E+ Q E++ E + K+++Q+ +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK--IREQEEIWRQKEKIHEQEEKIRKQEEKM 559
Query: 139 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
R+ ++ + ++ E +E+ + + E +E E+ E Q++ E + E+
Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619
Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
+++ E ++ + E+ Q K++ EQ ++++ M++ ++ K+
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 259 KLMEKKNQELEVVRQQRERLQEE---LSQAESTIDELKEQVDAAL 300
+ EK ++ E +R+Q E++ E+ L Q E + E +E ++AA+
Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 64.3 bits (155), Expect = 6e-10
Identities = 58/275 (21%), Positives = 132/275 (48%), Gaps = 25/275 (9%)
Query: 82 EEEGLRAQV--RDLEEKLETLRLKRAEDKAKL-KELEKHKIQLEQVQEWKSKM--QEQQA 136
E+E +R Q R EEK+ KR E +AK+ ++ EK + Q E+++E + KM QE++
Sbjct: 449 EQEKIREQEEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507
Query: 137 DLQRRLKEARK---------------EAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
Q +++E K E +E KE+ E+ E +E
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
++ E ++++ E + + +++ E ++ + E+ + Q +++ EQ ++ +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG 301
+M++ +++ K+++ +K ++ E +R+Q E +QE+ + +++ EQ +
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687
Query: 302 AEEMV----EMLTDRNLNLEEKVRELRETVGDLEA 332
EE + E + ++ + L ++ +++E LEA
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 48.1 bits (113), Expect = 5e-05
Identities = 56/311 (18%), Positives = 136/311 (43%), Gaps = 27/311 (8%)
Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA----EERAESLQQEVEALKERV 198
++ +K + + EA R +E T + + +MA + + L+ E L R+
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228
Query: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 258
+ L+ + + + +++L ++ L L R K+++ KLQ
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288
Query: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA-ALGAEEMVEMLTDRNLNLE 317
+ ++ E ++ + L+ +L +A+ + + + Q +A LG E L+
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE------------LQ 336
Query: 318 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
+L+ V + E N +N + +E E +++E + +++E ++++ +E +
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEEKIR 392
Query: 378 DYQQTIKKYRQLTAHLQDVNR---ELTNQQEASVERQQQPPPETFDFKIKFAETKAH--A 432
+ ++ +++ ++ ++ R E+ ++E + RQ++ E + KI+ E K H
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQE 451
Query: 433 KAIEMELRQME 443
K E E ++ E
Sbjct: 452 KIREQEEKRQE 462
Score = 35.4 bits (80), Expect = 0.31
Identities = 17/106 (16%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
K+ ++E I+E ++ ++ + E E ++ E+K+ + ++ +E++ + + ++ E
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645
Query: 867 TQALLRKKEKEFEETMDALQADIDQL---EAEKAELKQRLNSQSKR 909
+ +R++E++ E + +Q +++ E + E ++++ Q ++
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691
Score = 34.7 bits (78), Expect = 0.53
Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%)
Query: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 871
++R+ + EL ++ I EEL E N +L + ++S + +++++ +LE + LL
Sbjct: 261 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319
Query: 872 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 908
+++ + E + + ++ A + Q + E+ EL RLN Q +
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 360
Score = 34.7 bits (78), Expect = 0.53
Identities = 17/83 (20%), Positives = 49/83 (59%), Gaps = 3/83 (3%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
K+ ++E I+E ++ ++ + E + E ++ E+K+ + ++ +E++ + + ++ E
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701
Query: 867 TQALLRKKEKEFEETMDALQADI 889
+ LR++E++ +E + L+A I
Sbjct: 702 QEVRLRQQEEKMQEHQEHLEAAI 724
Score = 33.1 bits (74), Expect = 1.6
Identities = 23/99 (23%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
K+ D+E I+E ++ + + E++ E ++ E+K+ + E+ EK+ + EE
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ-EEKMC 623
Query: 870 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
+K +E EE M + I + E + E ++++ Q +
Sbjct: 624 EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662
Score = 31.2 bits (69), Expect = 5.9
Identities = 18/109 (16%), Positives = 58/109 (53%), Gaps = 6/109 (5%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
K+ ++E I++ ++ + + E++ + ++ E+K+ + ++ +E+I + + ++ E
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 867 TQALLRKKEK---EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
+ + +++E+ E EE M + + + E + ++++ Q K+ E
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 91.3 bits (225), Expect = 5e-18
Identities = 73/352 (20%), Positives = 180/352 (51%), Gaps = 28/352 (7%)
Query: 81 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
++EE LR Q +R+ EEK+ + E + +L+E EK + ++++E + +MQEQ+
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
+ + ++ R++ ++ +ER E+ + + +E E+ E L+++ E ++E+
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 198 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
+++ +E ++ E + + + + K EE+ R ++ +R + + E++E ++
Sbjct: 417 -EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 258 QK----LMEKKNQELEVVRQQRERL--QEELSQAESTIDELKEQV---------DAALGA 302
Q+ E+K + + + +Q+E+L QE++ + E I E +E++ + +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDL-EAMNEMNDELQENARETELELREQLDMAGAR 361
+E + D+ EEK+R+ + + D E M + E ++ + E ++RE+ R
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-----ER 590
Query: 362 VREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 413
+RE +K++ +E + + ++ K ++ +Q+ ++ Q+E E++++
Sbjct: 591 MREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Score = 88.2 bits (217), Expect = 4e-17
Identities = 88/392 (22%), Positives = 184/392 (46%), Gaps = 47/392 (11%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKLETLRL--------------------KRAEDKAKLKELE 115
LP E+ ++ V++L+ KLE + R ++K K+ E
Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 116 KHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATL 175
K Q E+++E + KM+EQ+ + R+ K R++ KE L +E+ + E + + E
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELREQKELREQEEQMQE 352
Query: 176 DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR 235
+E E+ E ++++ E + R +E + E E E+K D Q +++ EQ+ R
Sbjct: 353 QEEKMWEQEEKMREQEEKM-WRQEERLWEQEKQMREQEQKMRD------QEERMWEQDER 405
Query: 236 LKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 291
L++ RMR+ EK K + EKK ++ E Q+ ER++E + +
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465
Query: 292 LKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 351
++EQ + EE + ++ ++++ E +E + + E M E +++ E E ++
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEKMQEQEEKIWEQ----EEKI 520
Query: 352 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 411
R+Q +M G Q++ QE + + + + + + ++D +++ +Q+E ++
Sbjct: 521 RDQEEMWG------QEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKMWDQEERMEKKT 571
Query: 412 QQPPPETFDFKIKFAETKAHAKAIEMELRQME 443
Q+ +T+D + K E + + E ++R+ E
Sbjct: 572 QEQEKKTWDQEEKMRE-EERMREREKKMREEE 602
Score = 85.1 bits (209), Expect = 3e-16
Identities = 86/402 (21%), Positives = 184/402 (45%), Gaps = 35/402 (8%)
Query: 81 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
++E+ LR Q +R+ EE+++ K E + K++E E+ K+ ++ + W+ + Q ++ +
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQ 390
Query: 139 QRRLKEARK-EAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA-----ESLQQEVE 192
+ R +E R E E L KE M E + +E +K+M E+ E QE E
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252
++ER ++ + E ++ E EEK + ++ ++ E Q RL + ++ + ++Q
Sbjct: 451 RIREREKKMREEEETMR-EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 253 EHV------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
E K++ E QE ++ RQ++ R QE+ Q +++++Q EE +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED--QMWEQEEKMRDQEQKMWDQEERM 567
Query: 307 EMLT-----------------DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 349
E T +R E+K+RE E + + E + +E + E
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627
Query: 350 ELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 409
E E++ ++ E ++++ +E + + Q+ ++ +L H + +E +QE +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 410 RQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 451
Q++ +T + + K + + + M R+ ++ + M
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Score = 81.6 bits (200), Expect = 4e-15
Identities = 75/388 (19%), Positives = 179/388 (46%), Gaps = 25/388 (6%)
Query: 81 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
+EE+ ++ Q RD EEK++ R +K +E E + Q E++Q+ + M EQ+
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 138 --LQRRLKEARK---EAKEALEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEV 191
Q+RL E ++ E ++ E +E+ E+ D EM +K+M +E+ + ++
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 192 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEK 251
+E++ + + + +E+K + ++ ++ + R+++ +MR+ +
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 252 QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE---- 307
++ K+Q+ EK ++ E + +Q E++QE+ + +++ EQ + + + E
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 308 MLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ------------ENARETELELREQL 355
+ + +EK++E E + + E M + E + E+ RE E ++RE+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 356 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
+M + + Q++ E QE + + +K + + + R +++ + Q
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 416 PETFDFKIKFAETKAHAKAIEMELRQME 443
+ ++ + K + + + E ++R E
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/320 (21%), Positives = 155/320 (48%), Gaps = 20/320 (6%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAE--DKAKLKELEKHKIQLEQVQEWKSKMQEQQA--- 136
E+E ++ Q + E+ E +R + + K+ EK + Q +Q+ E + KM++Q+
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
D + R+++ +E ++ +E M E + + ++EM E+ E +Q++ E ++E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 197 RVDELTTDLEILKA------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250
+ +++ E ++ E EEK + ++ ++L EQ +L + E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE------STIDELKEQVDAALGAEE 304
++E + Q+ MEKK QE E +E+++EE S E + ++EQ + EE
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 305 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 364
++ + EEK+ E E + + + + E ++L E+ + E +E++ ++R+
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE---QEKIWEQEEKMRD 798
Query: 365 AQKRVEAAQETVADYQQTIK 384
++++ +E + ++ ++
Sbjct: 799 QEEKMRGQEEKMRGQEEKMR 818
Score = 75.9 bits (185), Expect = 2e-13
Identities = 76/337 (22%), Positives = 154/337 (45%), Gaps = 36/337 (10%)
Query: 92 DLEEKLETLRLKRAEDKAKLKELEKHK----IQLEQVQEWKSKMQEQQADLQRRLKEARK 147
+L+ L + + + ++EL K + ++L + +++++ A+LQ +L A
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 148 EAKEA-LEAKE--RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE-----RVD 199
E E L KE R +E ++ TL +EM + E +QE + K+ R +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
E + E E EEK Q K+L EQ L++ +R+ +QE ++Q+
Sbjct: 300 ERLREQEGKMREQEEK------MWRQEKRLREQEKELREQEKELREQKELREQEE-QMQE 352
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 319
EK ++ E +R+Q E++ + + +++EQ EE + +R EE+
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 320 VRELRETVGDLEAMNEMN--DELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 377
+RE + +E M E E ++ R+ E +++E+ R+RE +K++ +ET+
Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-----ERIREREKKMREEEETMR 467
Query: 378 DYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQP 414
+ ++ ++K + + Q+E ++Q+ P
Sbjct: 468 EQEEKMQKQEE----------NMWEQEEKEWQQQRLP 494
Score = 64.7 bits (156), Expect = 5e-10
Identities = 64/281 (22%), Positives = 139/281 (49%), Gaps = 28/281 (9%)
Query: 81 KEEEGLRAQVRDLEEKLETL--RLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 138
++EE ++ Q + E+ E + + ++ ++ +L E ++ + E++QE + KMQEQ+ +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE-QEKMQEQEEKI 686
Query: 139 --QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 196
Q ++++ +E ++ +E+ EE + +M ++EM E+ E +Q++ E ++E
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE-EEEMMREQEEKMQEQEEKMQE 745
Query: 197 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 256
+ +E+ E EEK + ++ ++L EQ +L + + QE K
Sbjct: 746 QEEEMW--------EQEEKMWEQEEKMWEQQRLPEQKEKLWE---------HEKMQEQEK 788
Query: 257 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 316
+ + EK + E +R Q E+++ + + +++ Q + G EE + ++
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 317 EEKVRELRETVGDLEAMNEMNDEL---QENARETELELREQ 354
EEK+ E + G E M E +++ +E RE E ++R Q
Sbjct: 849 EEKMEEKMQ--GQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Score = 33.1 bits (74), Expect = 1.6
Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 5/102 (4%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
K+ ++E ++E ++ + + E L E ++ E+K+ +D +ER+ + RL E +
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM----RDQEERMWEQDERLREKEE 411
Query: 870 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTI 911
+R++EK +E+ ++ ++ + E EK Q Q + I
Sbjct: 412 RMREQEKMWEQ-VEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Score = 32.0 bits (71), Expect = 3.5
Identities = 22/103 (21%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV---QTRLEE 866
K+ + E++ +E +K ++ + E + E ++ E+K+ ++ E+ EK+ + ++ E
Sbjct: 708 KMREEESM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 867 TQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909
Q L +KEK +E Q I + E + + ++++ Q ++
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809
Score = 31.6 bits (70), Expect = 4.5
Identities = 23/114 (20%), Positives = 56/114 (49%), Gaps = 13/114 (11%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV--------- 860
++ +RE ++E ++ ++ + E++ E ++ E+K+ + E+ EK+
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 861 -QTRLEETQALLRKKEKEFEETMDALQADIDQLEA---EKAELKQRLNSQSKRT 910
+ ++ E Q L +KEK +E Q + + E E+ +++++ Q K+T
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
Score = 30.8 bits (68), Expect = 7.7
Identities = 23/112 (20%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 869
K+ D+E + E + L+ K E + E +EK + E+ + Q + +
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 870 LLRKKEKEFEETMDALQADIDQL---------EAEKAELKQRLNSQSKRTIE 912
+R++EK+ E + ++ +++ + EK +QRL Q ++ E
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 91.3 bits (225), Expect = 5e-18
Identities = 199/973 (20%), Positives = 384/973 (39%), Gaps = 169/973 (17%)
Query: 76 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 124
L KE+ +V++L E++ ET+ E KA L +L+ + ++ +
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
Query: 125 QEWKSKMQEQQADLQRRLKEARK------EAKEALE-----AKERYMEEMADTADA---- 169
+ K K+++Q DL+ L++ +K AK LE A+E M+ D
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 170 ----IEMATLDKEMAEERA--ESLQQEVEALKERVDELTTDLEI---LKAEIEEKGSD-- 218
EM+ L ++ +E+A LQ++++ L+ R++EL ++E +A+ E++ SD
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 219 -------------GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK- 264
G A+S Q++ +++ A + RDL + Q L +K
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKHA 1201
Query: 265 ------NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNL 314
++++ +++ +++L++E S+ + ID+L ++ A E+M L D+
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261
Query: 315 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 374
++ K E + + DL A LQ + E +L E+ + R Q + +E
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRA---RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 375 TVADYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIK 424
++ IK L LQ + + +QEA E Q+ + E ++ K
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 425 FAETKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLL 477
+ ET A + E+E + ++AQ A H+ + A + + R + + +++ +
Sbjct: 1379 Y-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 478 MPRLICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLL 529
C A +++ +K E + C E L + E S + L Y SL
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497
Query: 530 QA-TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLD 578
Q TL R L Q D+ +++ + ++ + L +E
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 579 ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------R 632
E + + + + +AE+ E+ +HI+ +S + E+ R
Sbjct: 1558 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617
Query: 633 LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDT 692
L+ ++G L ++E + + + R T A L + D
Sbjct: 1618 LKKKMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL----HLDDA 1664
Query: 693 LL---DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 749
L D ++ L V + A +L A L + E A +EL ASE++
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV------ 1717
Query: 750 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 809
+ L LI+T KL T + + + + E + E +A + ITDA +
Sbjct: 1718 ---QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAAMMAE 1771
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIE 858
+L+ + L++ K + + + RL E+ KL++ ++ + +E
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831
Query: 859 KVQTRLEETQALLRKKEKEFEE-----------------TMDALQADID--QLEAEKAEL 899
Q R E LRK E++ +E +D LQA + + +AE+AE
Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 900 KQRLNSQSKRTIE 912
+ +N R I+
Sbjct: 1892 QSNVNLSKFRRIQ 1904
Score = 89.4 bits (220), Expect = 2e-17
Identities = 174/877 (19%), Positives = 353/877 (40%), Gaps = 107/877 (12%)
Query: 74 PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ----VQEWKS 129
P L S E+E + +++E+ E + + A+ +AK KELE+ + L Q +Q
Sbjct: 842 PLLKSAETEKE-----MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896
Query: 130 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189
+ AD + R + K K LEAK + + E A+ + I K+ L+
Sbjct: 897 AEADSLADAEERCDQLIK-TKIQLEAKIKEVTERAEDEEEINAELTAKK------RKLED 949
Query: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249
E LK+ +D DLE+ A++E+ + A+ ++K L E+ A L + + ++ +
Sbjct: 950 ECSELKKDID----DLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TK 998
Query: 250 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309
EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ + M
Sbjct: 999 EK------KALQEAHQQTLDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKIRMD 1051
Query: 310 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
+R LE ++ +E+ D+E + DE + L+ +++ A + QK+
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKK 1111
Query: 369 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 428
++ Q + + ++ I+ R A + +L+ + E ER ++ T +
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMN 1168
Query: 429 KAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 486
K + R +E A Q + L DS G D + + K +
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQK 1220
Query: 487 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 546
L +++++ K E+ + S + A G L LS ++ + ++ D
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN----D 1276
Query: 547 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 606
+ + L E + R LD KD L V L++ + + +Q E
Sbjct: 1277 LTAQRARLQTESGEYSRQLD------EKDTL-----VSQLSRGKQAF--------TQQIE 1317
Query: 607 DCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF 663
+ QL + IK + AL + LR + QEA A L R + + S++ Q+
Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK--AELQRAMSKANSEVAQW 1375
Query: 664 CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
K TDA Q ++ L + +K L + +E A A L +
Sbjct: 1376 RTKYE-----TDA----------IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERP 783
+ L +E+L E +C L + E + E
Sbjct: 1421 TKQRLQNEVEDLMIDV-------------ERTNAACAALDKKQRNFDKILAEWKQKCEET 1467
Query: 784 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE 843
++ + + +L E+ + + D+ +K K+L+ + +L+E
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527
Query: 844 KKLDSAAKDADERIEKVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELK 900
+L+ K ++ ++Q LEE +A L +E + + ++ +++++D+ AEK E
Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1587
Query: 901 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRG 937
++ R +E ++ + I + I +++ G
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624
Score = 55.1 bits (131), Expect = 4e-07
Identities = 52/278 (18%), Positives = 129/278 (46%), Gaps = 13/278 (4%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+
Sbjct: 1662 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1717
Query: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV---D 199
+ + + K++ +++ +E + AEE+A+ + + E +
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 200 ELTTDLEILKAEIEEKGSD-----GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEH 254
+ + LE +K +E+ D A LK ++Q +L+ + + SE++ +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837
Query: 255 VKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNL 314
V+ K + K ++++ + Q E ++ + + + +D+L+ +V + E E ++ NL
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897
Query: 315 NLEEKVR-ELRETVGDLEAMNEMNDELQENARETELEL 351
+ +++ EL E + ++L+ +RE ++
Sbjct: 1898 SKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/257 (21%), Positives = 115/257 (44%), Gaps = 40/257 (15%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 127
+ +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 128 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 182
K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 183 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEE-QNAR 235
++L+Q V+ L+ R+DE +I K E + +G S Q + +E + R
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 236 LKDALVRMRDLSSSEKQEHV-KLQKLMEKKNQELEVVRQQRE--------------RLQE 280
+ V+ + E ++++ +LQ L++K +++ ++Q E R+Q
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 281 ELSQAESTIDELKEQVD 297
EL +AE D + QV+
Sbjct: 1906 ELEEAEERADIAESQVN 1922
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2207 EELQRLKAEATEAAR 2221
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1781
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1902 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1945
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2002
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 2003 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2052
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2053 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2093
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2212 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2269
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2270 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2298
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2352
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2353 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ 2484
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1667
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1966
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2025
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2083
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2084 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2187
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2245
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2303
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2360
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2361 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2479 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2522
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2257
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2498 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2302 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2417
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2473
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2474 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2523
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2524 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2579
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1571
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1627
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1803
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1846
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1892
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1947
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1948 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1980
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1981 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2034
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2211 EELQRLKAEATEAAR 2225
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1480 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1529
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1581
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1582 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1684
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1723
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1724 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1776
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1837 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1937
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1938 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2048
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2049 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2099
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2100 ARVQAEREAAQSRRQVE 2116
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1057 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1116
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1117 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1232
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1406
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1467 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1580
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1757 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1874
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1930
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2461
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2462 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2566
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2623
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2680
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2727
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 977 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1031
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1152 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1269 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1322
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1323 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1434
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1435 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1476
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1651
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1766
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1827 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1878
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2207 EELQRLKAEATEAAR 2221
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2096 ARVQAEREAAQSRRQVE 2112
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1745
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1866 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1909
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1966
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1967 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2016
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2017 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2057
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2176 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2233
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2234 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2262
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2316
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2317 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ 2448
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1631
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1930
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1989
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2047
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2048 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2151
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2209
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2267
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2324
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2325 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2443 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2486
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2221
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2462 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2266 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2381
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2437
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2438 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2487
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2488 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2543
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1535
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1591
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1767
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1810
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1856
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1911
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1912 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1944
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1945 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 1998
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2175 EELQRLKAEATEAAR 2189
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1444 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1493
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1545
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1546 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1648
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1687
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1688 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1740
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1801 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1901
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1902 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2012
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2013 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2063
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2064 ARVQAEREAAQSRRQVE 2080
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1021 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1080
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1081 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1196
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1370
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1431 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1544
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1721 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1838
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1894
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2425
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2426 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2530
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2587
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2644
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2691
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 941 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 995
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 996 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1116 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1233 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1286
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1287 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1398
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1399 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1440
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1615
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1730
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1791 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1842
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1914
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 2035 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 2078
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2135
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 2136 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2185
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2186 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2226
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2345 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2402
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2403 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2431
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2485
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2486 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ 2617
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1800
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 2099
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2158
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2216
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2217 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2320
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2378
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2436
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2493
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2494 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2612 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2655
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2390
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2631 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2435 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2550
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2606
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2607 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2656
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2657 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2712
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1704
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1760
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1936
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1979
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 2025
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 2080
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 2081 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2113
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 2114 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2167
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2344 EELQRLKAEATEAAR 2358
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1613 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1662
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1714
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1715 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1817
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1856
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1857 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1909
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1970 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 2070
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 2071 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2181
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2182 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2232
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2233 ARVQAEREAAQSRRQVE 2249
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1190 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1250 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1365
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1539
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1600 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1713
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1890 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 2007
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 2063
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2594
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2595 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2699
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2756
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2813
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2860
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 1110 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1164
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1285 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1402 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1455
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1456 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1567
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1568 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1609
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1784
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1899
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1960 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 2011
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1755
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1876 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1919
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1976
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1977 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2026
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2027 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2067
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2186 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2243
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2244 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2272
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2326
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2327 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQ 2458
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1641
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1940
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1999
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2057
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2058 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2161
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2219
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2277
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2334
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2335 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2453 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2496
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2053
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2231
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2472 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2276 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2334
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2391
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2447
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2448 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2497
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2498 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2553
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1545
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1601
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1777
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1820
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1866
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1921
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1922 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1954
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1955 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2008
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2069 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2128
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2185 EELQRLKAEATEAAR 2199
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1454 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1503
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1555
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1556 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1658
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1697
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1698 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1750
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1811 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1911
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1912 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1965
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2022
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2023 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2073
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2074 ARVQAEREAAQSRRQVE 2090
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1031 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1090
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1091 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1206
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1380
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1441 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1497
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1498 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1554
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1731 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1848
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1904
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2435
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2436 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2540
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2597
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2654
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2701
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 951 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1005
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1006 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1065
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1126 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1243 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1296
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1297 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1408
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1409 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1450
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1625
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1740
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1801 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1852
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1763
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1884 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1927
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1984
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 1985 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2034
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2035 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2075
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2194 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2251
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2252 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2280
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2334
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2335 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQ 2466
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1649
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1948
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2007
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2065
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2066 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2169
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2227
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2285
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2342
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2343 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2461 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2504
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2061
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2239
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2240 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2299
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2480 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2284 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2342
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2399
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2455
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2456 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2505
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2506 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2561
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1553
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1609
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1785
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1828
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1874
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1875 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1929
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1930 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1962
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 1963 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2016
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2077 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2136
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2193 EELQRLKAEATEAAR 2207
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1462 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1511
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1563
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1564 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1616
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1617 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1666
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1705
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1706 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1758
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1819 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1919
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1920 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1973
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2030
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2031 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2081
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2082 ARVQAEREAAQSRRQVE 2098
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1039 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1098
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1099 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1157
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1214
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1388
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1449 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1505
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1506 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1562
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1739 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1856
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1912
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2443
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2444 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2548
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2605
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2662
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2663 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2709
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 959 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1013
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1014 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1073
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1134 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1251 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1304
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1305 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1416
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1417 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1458
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1633
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1748
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1809 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1860
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
E E Q + LEE+L L+ + A K +ELE +L +V+ + +A +
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1804
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 196
+ +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
Query: 197 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 242
++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L +
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
Query: 243 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 302
+R S SE +E++ +E +QR +++EE+ +++ ++ AA G
Sbjct: 1925 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1968
Query: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
E+ L N E+ +R + +LEA + +E R E E R Q +A
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2025
Query: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 421
EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q
Sbjct: 2026 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2075
Query: 422 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 481
AE KAHA A++ + ++++ + S+L G+ + R
Sbjct: 2076 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2116
Query: 482 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 540
+AE R QA+ E + E L+ +A EQ A + L+ +
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176
Query: 541 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 599
+Q ++ + EM H++ + + K Q+++ + L + + ++L
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 600 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 659
L + T + A + L + V++ L L+ EA + AL+LRD + +
Sbjct: 2235 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2292
Query: 660 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 719
+++ +K++ QV++ A VAA A +
Sbjct: 2293 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2321
Query: 720 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 777
LAE + AL E K Q T + E L+Q + + A +QE
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2375
Query: 778 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 836
D E+ A AE T L+ E R+ + + LK++ E+S A
Sbjct: 2376 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 893
R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 894 AEKAELKQ-----RLNSQSKRTIE 912
EK +L+Q +L S+ +T++
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQ 2507
Score = 86.7 bits (213), Expect = 1e-16
Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%)
Query: 81 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
+EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ +
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1690
Query: 140 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 171
++ +EA +EA+ +A+E+ + +E+ E
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
Query: 172 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 220
+++ EE LQ+E A ++ EL +L ++AE+ EE S
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810
Query: 221 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 260
S +L ++L E+ ARL+ + R R L+ + + E V +KL
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 261 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 301
+++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 302 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 347
+E +VE + +EE++ L+ + G E E+ ++ NA +T
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1989
Query: 348 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 397
ELE Q +A R REA++RV+ A +E + +++ +L A +++
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2048
Query: 398 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 457
R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2106
Query: 458 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 516
G+ + R +AE R QA+ E + E L+ +A EQ
Sbjct: 2107 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 517 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 576
A + L+ + +Q ++ + EM H++ + L K Q
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2210
Query: 577 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 635
+++ + L + + ++L L + T + A + L + V++ L +
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2268
Query: 636 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 694
L+ EA + AL+LRD + + +++ +K+++ +A + A ++
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2326
Query: 695 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 754
D + +L+E A + AE E L+ +ELA + + ++ +
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2383
Query: 755 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 808
L + T+ A ++ E AE K E+ A RAE AE +G
Sbjct: 2384 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 809 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 858
KL E +E L ++L+I+ E L EA L ++KL AK + E
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501
Query: 859 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 901
++QT L+ETQAL ++ F D+L +E EKA+L+Q
Sbjct: 2502 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2545
Score = 85.1 bits (209), Expect = 3e-16
Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%)
Query: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 136
+K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102
Query: 137 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 194
L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 195 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 246
KE E + +A + +K + A K E+ Q A+++ L +R L
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 247 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 306
++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2280
Query: 307 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 363
+L D++ L+E+ ++++ + ++ E + E +L +Q +A ++
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 364 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 409
E + V+ A A+ QQ + ++ LQ+ ++ Q EA +
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 410 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 459
RQ + E K++ AE ++A A+A E R Q E H + L T
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 516
R DHD + + L + E ++++A Q K E + + L+ Q
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 517 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 566
SF L SLLQ + + + L Q D K L E ++ ++
Sbjct: 2521 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Score = 84.7 bits (208), Expect = 4e-16
Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%)
Query: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 141
EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++
Sbjct: 2325 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2440
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 261
L + +EK + Q +Q + RL++A+ + EK++ + KL+
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2496
Query: 262 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 321
+ K++E++ V QQ + LQE + +S + E D+ L E +E LE+
Sbjct: 2497 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2546
Query: 322 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 381
++ V + + E Q+ + L ++ A R EA++ V QE + QQ
Sbjct: 2547 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2602
Query: 382 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
++ RQ L + N+ L Q + E+ +
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
Score = 84.0 bits (206), Expect = 8e-16
Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%)
Query: 86 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 141
+ ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 142 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 201
++A E ++A+ E A+E L E AE R Q EVE ++ L
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1594
Query: 202 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 260
T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1650
Query: 261 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 310
E+ +ELE +R Q E + ++ S A++ ++ KE+ + E
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 311 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 365
R L E+ E + + + A + EL ETE + R+ L+ AR+ REA
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 425
+ QE A+ + + L A E + E S +R + E F+ +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1826
Query: 426 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 484
AE A +A+ E RQ ++A+ + R + + VL +L
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1869
Query: 485 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 544
E R + + + L E +E LR A ++ R E +Q
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1915
Query: 545 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 604
D+ +++ L + L+E D L + VE A+K + AE
Sbjct: 1916 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1970
Query: 605 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 664
+ +E+GR+R+ A D E + RQ
Sbjct: 1971 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2003
Query: 665 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 724
+ RR + + +LA + + + + + A ++E A+ + AE
Sbjct: 2004 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2057
Query: 725 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 780
E L + A +A E+ + + L+Q+ S +++L + A
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117
Query: 781 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 840
E E AA R ++ +AE L E++ + + + + +E + R +
Sbjct: 2118 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2177
Query: 841 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 900
E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 901 QRLNSQSKRTIEGLR 915
+ L E R
Sbjct: 2234 EELQRLKAEATEAAR 2248
Score = 82.4 bits (202), Expect = 2e-15
Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%)
Query: 87 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 145
R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ +
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
Query: 146 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 205
++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 206 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 257
+ L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L
Sbjct: 1503 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1552
Query: 258 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
+ EK+ Q LE +R Q E + L QAE E QV AL +
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1604
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
L+ K E LE LQE +LRE+ + + EA++ E A+
Sbjct: 1605 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1657
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 435
+ +Q + +L ++V ++ + Q A E+Q++ E + KA
Sbjct: 1658 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1707
Query: 436 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 491
E +RQ E+A + R ++ TA RL + ELIR +
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1746
Query: 492 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 551
A E + +R L AA L+A L + ++ V + K
Sbjct: 1747 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1799
Query: 552 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609
+ S E+S L ++ +E + L + K + L A Q +
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859
Query: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 666
LA+ +L A + + T+ + L++ E +R+ +
Sbjct: 1860 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 667 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 723
RRR+ A I LA + SD+ L+ +K L V L++ +++A A
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1960
Query: 724 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 781
E E E G S+ + LR + + + +LA + +AE
Sbjct: 1961 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2014
Query: 782 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 836
K E AA R A + + E L K+E+ RE +E + L++ E A
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2071
Query: 837 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 896
RL EK + A ++ +++Q L++ Q++L + E E A + EAE+
Sbjct: 2072 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2122
Query: 897 AELK-QRLNSQSKRTIE 912
A ++ +R +QS+R +E
Sbjct: 2123 ARVQAEREAAQSRRQVE 2139
Score = 70.9 bits (172), Expect = 7e-12
Identities = 189/956 (19%), Positives = 362/956 (37%), Gaps = 121/956 (12%)
Query: 76 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 121
LP PS LR+ QVR L EKL+T+ L + + L H+ QL
Sbjct: 1080 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1139
Query: 122 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 181
++ Q + + E +A + LK+ R +A+ + +E+ + E +
Sbjct: 1140 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198
Query: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 241
E ++ V L ER + ++ + E+E+ G Y + + A L+DA
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1255
Query: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 294
R + + + +++ + ++ LE + + E+++E A+ I+ +K+
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315
Query: 295 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 341
+ G+E +++ D + E + + + +E +
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375
Query: 342 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 401
A + E RE+L A + + ++ EA + A ++ K+ + Q + E+
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1429
Query: 402 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 459
++EA+V+ QQQ E + +E + AKA + E + + + ++ +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 460 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 509
+ + GG + L +AE ++QAQE+ E + R
Sbjct: 1490 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1546
Query: 510 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 567
A E + +L L+ E L Q V+ ++V + +RS +
Sbjct: 1547 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1603
Query: 568 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 624
++ ++T +E + +H+ L E+ E Q A+ + + A L+
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Query: 625 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 662
++ LR LQ + A +L + E + Q
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 663 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 716
+K R+ GT + A ++T R+ L +A LQ AAAA Q
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 717 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 767
L A LA+ + L A +A E+ T S + L + L +
Sbjct: 1780 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 768 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 822
+ Q E DA R ++ V A E T+AE + LK ++ E ++ L
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1897
Query: 823 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 881
+ + L E A + +E++L K +D +E+ + +E+T ++ ++ EE
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1953
Query: 882 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI-ATLVSGIAGEEQQR 936
+ AL+A ++ A KAEL+ L + LR + + A +A EE++R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
Score = 66.2 bits (160), Expect = 2e-10
Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%)
Query: 81 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 140
++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2484
Query: 141 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 200
++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + +
Sbjct: 2485 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 201 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 257
+E KA++E+ D A + QL++ E+Q + + R R ++S E +++H +
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2589
Query: 258 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2646
Query: 314 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 373
+ + + R+ + A E R+ ++L AG E +R+
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2703
Query: 374 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 415
TV + ++ ++ Y Q + + + + TN++ A+++RQ P
Sbjct: 2704 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2750
Score = 63.5 bits (153), Expect = 1e-09
Identities = 198/1006 (19%), Positives = 396/1006 (39%), Gaps = 116/1006 (11%)
Query: 133 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 187
EQ A + R + E K+ R E +T + LDKE A E A+ +
Sbjct: 1000 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1054
Query: 188 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 235
Q EVE L + V L+ + E + A E + S +L+Q+ +A +
Sbjct: 1055 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1114
Query: 236 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
LK + +R +E+ +E +K + + ELE + ++L+ + + T D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174
Query: 291 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 346
L++++ GA+E+ E L R+ + +V RE V L +A+ D Q +
Sbjct: 1175 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 347 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 402
+L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291
Query: 403 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 462
+E +Q D++++ KA + + ++ +V + S++ ++
Sbjct: 1292 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1345
Query: 463 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 522
LR H L L + +E +R+ +E+ + +E L L
Sbjct: 1346 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
Query: 523 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 582
+ + +A R L Q + + + +RS+ ++ QL ++
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1457
Query: 583 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 642
E KA AE E +++ + I+ + L+ + +GG E
Sbjct: 1458 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1499
Query: 643 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 697
AL R + E ++ +++RR++ A + +V ++ + +
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
Query: 698 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 752
+ L + + + A +L E + ALE A ++ +S +
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 753 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812
E Q ++ ++ + + A + + +AER + EL L+A E L L+L+
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1674
Query: 813 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 862
E K L ++ K +E +E R E++ + A++ +EK Q
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 863 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 920
RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E +
Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1789
Query: 921 GIATLVSGIAGEEQQRGAIPGQAPGSVPGPG----LVKDSPLLLQQISAMRLHISQLQHE 976
+ L++ A E++ + ++ + + + L+ ++ QL E
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 977 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1034
++ + A+ + LA KL+ G + L A ++ E L +L+
Sbjct: 1850 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1901
Query: 1035 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1080
R A A + E++AQL+ SD+ + + ++++T+ QR
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 90.9 bits (224), Expect = 6e-18
Identities = 81/405 (20%), Positives = 188/405 (46%), Gaps = 41/405 (10%)
Query: 82 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 139
E + L +++ + KL+ +++ E +L + ++ K+ Q E++QEW+ K+QEQ+ +
Sbjct: 266 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 323
Query: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199
R +E +E +E + +E M E + E +KE R E + E E ++
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 200 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 259
E + E ++ + E++ + + +Q EQ A++ ++R+ +++ K+ +
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQ--EQEAKMWRQEEKIREQEEKIREQEKKMWR 441
Query: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE-----------------------QV 296
EK +++ ++ +++ + QEE+ + E I E +E Q
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE 501
Query: 297 DAALGAEEMVEMLTDRNLNLEEKVRE----LRETVGDLEAMNEMNDELQENARETELELR 352
+ EE + ++ EEK+RE +RE + EM E +E E E +++
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 353 EQLDM--AGARVREAQKRVEAAQETVADYQQTI----KKYRQLTAHLQDVNRELTNQQEA 406
EQ M ++RE ++++ +E + + ++ I +K R+ +Q+ ++ Q+E
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621
Query: 407 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 451
E++++ + + K++ E K + + + ++ ++ + H+
Sbjct: 622 MCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 85.9 bits (211), Expect = 2e-16
Identities = 88/414 (21%), Positives = 187/414 (45%), Gaps = 49/414 (11%)
Query: 68 TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 127
TS G P + A R+LE ++ T+R+ + K +L+ + L Q
Sbjct: 100 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 152
Query: 128 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 173
+++ + DL RL ++ K E ++AL A +RY+EE+ DA+ +
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212
Query: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 217
T+ E +E+ LQ++++ ++ E+ +++ LK AE + G
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 272
Query: 218 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 272
+ + S +L+ E+N L + L + ++ ++E + K+Q+ EK ++ E +R
Sbjct: 273 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 273 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 332
+Q E+++ + ++++ Q + EE + L + EEK+REL E + + E
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK 391
Query: 333 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 392
+ E ++ QE + E E R++ + A++ ++++ +E + + ++ + + +
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448
Query: 393 LQDVNRELTNQQEASVERQQQ---PPPETFDFKIKFAETKAHAKAIEMELRQME 443
+ + E Q++ + RQ++ E + K K E + K E RQ E
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE 502
Score = 79.7 bits (195), Expect = 1e-14
Identities = 76/303 (25%), Positives = 154/303 (50%), Gaps = 32/303 (10%)
Query: 89 QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 136
++R+LEEK+ E +++ E+K K++E EK + Q E+++E + K++EQ+
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437
Query: 137 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 193
+ R+ ++ ++ K E K + EEM + I E KE E+ + +QE +
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 194 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 253
++ +E D E E EEK Q +++ EQ ++++ ++R+ +++
Sbjct: 498 WRQ--EEKMHDQEEKIREQEEK------MWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 254 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 313
K+ + E+K QE E +R+Q E+++E+ + ++++EQ + EE + +
Sbjct: 550 EEKMGE-QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608
Query: 314 LNLEEKVRELRETVGDL-EAMNEMNDEL---QENARETELELREQLDMAGARVREAQKRV 369
EEK+ E E + + E M E +++ +E E E+ LR+Q + +++E Q+ +
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHL 664
Query: 370 EAA 372
EAA
Sbjct: 665 EAA 667
Score = 79.3 bits (194), Expect = 2e-14
Identities = 71/337 (21%), Positives = 153/337 (45%), Gaps = 25/337 (7%)
Query: 81 KEEEGLRAQVR---DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
++EE +R Q + EEK+ L E + K++ELE+ + E+++E + K QE++
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405
Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDK--EMAEERAESLQQEVEALK 195
++ ++ ++ E K R EE + +K E + R E +QE E +
Sbjct: 406 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 465
Query: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 255
+ +++ EI + + ++ +++ +Q ++ +M D +++
Sbjct: 466 RQEEKIREQEEIWRQK---------EKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 256 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 315
K+ + EK ++ E +R+Q E+++E+ +E+ ++ + +G +E ++
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQ--------EEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 316 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 375
EEK+RE E + + E E +E E E ++REQ +M + + ++ E E
Sbjct: 569 QEEKIREQEEKIRE---QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625
Query: 376 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 412
Q+ +K R+ + + L Q+E E Q+
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 63.5 bits (153), Expect = 1e-09
Identities = 47/212 (22%), Positives = 110/212 (51%), Gaps = 12/212 (5%)
Query: 81 KEEEGLRAQV---RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
++EE +R Q R E+ E ++++ E+K +E + H Q E+++E + KM Q+
Sbjct: 466 RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD-QEEKIREQEEKMWRQEEK 524
Query: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
+ R +E +E +E + +E M+E + +M +++M E+ E ++++ E ++E+
Sbjct: 525 I-REQEEKIREQEEKIREQEEMMQEQEE-----KMGEQEEKMQEQ--EKMRRQEEKIREQ 576
Query: 198 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 257
+++ E ++ + E+ Q + ++EQ ++ + +M + +++ K+
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 636
Query: 258 QKLMEKKNQELEVVRQQRERLQEELSQAESTI 289
++ EK ++ +RQQ E++QE E+ I
Sbjct: 637 RRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 34.7 bits (78), Expect = 0.53
Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%)
Query: 812 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 871
++R+ + EL ++ I EEL E N +L + ++S + +++++ +LE + LL
Sbjct: 200 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 258
Query: 872 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 908
+++ + E + + ++ A + Q + E+ EL RLN Q +
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 299
Score = 33.9 bits (76), Expect = 0.91
Identities = 21/104 (20%), Positives = 58/104 (55%), Gaps = 5/104 (4%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
K+ D+E I+E ++ + + E++ E ++ E+K+ + ++ +E++ + + +++E
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562
Query: 867 TQALLRKKEK--EFEETMDALQADIDQLEAEKAELKQRLNSQSK 908
+ + R++EK E EE + + I + E + E ++++ Q +
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE 606
Score = 32.7 bits (73), Expect = 2.0
Identities = 17/83 (20%), Positives = 48/83 (57%), Gaps = 3/83 (3%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 866
K+ ++E I E ++ ++ + E + E ++ E+K+ + ++ +E++ + + ++ E
Sbjct: 586 KIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645
Query: 867 TQALLRKKEKEFEETMDALQADI 889
+ LR++E++ +E + L+A I
Sbjct: 646 QEVRLRQQEEKMQEHQEHLEAAI 668
Score = 32.0 bits (71), Expect = 3.5
Identities = 20/113 (17%), Positives = 55/113 (48%), Gaps = 10/113 (8%)
Query: 810 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLE----------KKLDSAAKDADERIEK 859
K+ ++E I+E ++ ++ + E + E ++ E ++L+ + +E+I +
Sbjct: 322 KIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE 381
Query: 860 VQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 912
++ ++ E + + ++EK EE Q + EA+ ++++ Q ++ E
Sbjct: 382 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,662,005
Number of Sequences: 37866
Number of extensions: 2109321
Number of successful extensions: 37511
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 1652
Number of HSP's that attempted gapping in prelim test: 14427
Number of HSP's gapped (non-prelim): 13031
length of query: 1144
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1031
effective length of database: 13,968,660
effective search space: 14401688460
effective search space used: 14401688460
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.