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Search of human proteins with 13236497
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
(357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 724 0.0
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 214 7e-56
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 214 1e-55
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 212 5e-55
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 206 3e-53
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 204 1e-52
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 204 1e-52
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 204 1e-52
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 197 2e-50
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 194 8e-50
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 194 8e-50
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 194 8e-50
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 194 8e-50
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 185 6e-47
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 177 1e-44
gi|4503383 dopamine receptor D1 [Homo sapiens] 172 3e-43
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 168 6e-42
gi|4503391 dopamine receptor D5 [Homo sapiens] 166 2e-41
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 165 5e-41
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 159 4e-39
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 157 1e-38
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 156 3e-38
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 155 4e-38
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 155 5e-38
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 150 2e-36
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 150 2e-36
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 147 1e-35
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 147 1e-35
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 147 1e-35
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 147 1e-35
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 724 bits (1870), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL 60
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
Sbjct: 1 MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL 60
Query: 61 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
Sbjct: 61 VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC 120
Query: 121 DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG 180
DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
Sbjct: 121 DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG 180
Query: 181 WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS 240
WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
Sbjct: 181 WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS 240
Query: 241 PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP 300
PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
Sbjct: 241 PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP 300
Query: 301 FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
Sbjct: 301 FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 214 bits (546), Expect = 7e-56
Identities = 122/340 (35%), Positives = 189/340 (55%), Gaps = 34/340 (10%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
+L+ L L T N LV+A I+ R H + L+ S+AV+D LVA LVMP S+V+
Sbjct: 24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVY 83
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
+ W +G+ +C +W++ D+ CCT SI +++AIALDRY +IT +EY + + +
Sbjct: 84 -IVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 142
Query: 161 MIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYA-VFSTVGAFYLPLCVVLFV 219
MI + W +S IS+ PL W + +EC + + + ++ST GAFY+PL ++L +
Sbjct: 143 MITIVWIISVFISMPPLF--WRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILIL 200
Query: 220 YWKIYKAAK--------FRVGSRKTN----------SVSPISEAVEVKDSAKQPQMVFTV 261
Y+KIY+AAK R+ + N S +S + ++ S P F
Sbjct: 201 YYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDK 260
Query: 262 RHATV-----TFQPEGDTWREQK-----EQRAALMVGILIGVFVLCWIPFFLTELISPLC 311
H+TV F+ E +WR QK E++AA +G+++G FV+CW+PFF+ EL+ +C
Sbjct: 261 IHSTVRSLRSEFKHE-KSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC 319
Query: 312 -SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
C I + WLGY NS NPLIYT FN+++ AF+
Sbjct: 320 DKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQ 359
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 214 bits (545), Expect = 1e-55
Identities = 125/334 (37%), Positives = 188/334 (56%), Gaps = 28/334 (8%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
VL++ LL + AT N V+AT+ R R H + L+AS+AV+D+LV+ LVMP+S ++
Sbjct: 50 VLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMY 109
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
++GR W LG+ +C W++ D+ CCTASI ++ IALDRYW+IT +EY+ + + V
Sbjct: 110 TVTGR-WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
Query: 161 MIALTWALSAVISLAPLLFGWGETYSEGS-EECQVSREP-SYAVFSTVGAFYLPLCVVLF 218
MIAL W S ISL P F W + +E EC V+ + Y V+STVGAFY P +++
Sbjct: 169 MIALVWVFSISISLPP--FFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIA 226
Query: 219 VYWKIYKAAKFRV--------GSR------------KTNSVSPISEAV-EVKDSAKQPQM 257
+Y +IY A+ R+ G R T+SV+ I+ V +V + P
Sbjct: 227 LYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVY 286
Query: 258 VFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCDI 315
V V+ E +E++A +GI++G F++CW+PFF+ L+ P+C +C
Sbjct: 287 VNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWF 346
Query: 316 PAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
F WLGY NS NP+IYT N+++ AF
Sbjct: 347 HLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 380
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 212 bits (539), Expect = 5e-55
Identities = 116/336 (34%), Positives = 185/336 (55%), Gaps = 22/336 (6%)
Query: 36 LSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMP 95
L + + +L + AT N VL TIL R H + L+ S+A +D+LV+ LVMP
Sbjct: 34 LQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP 93
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRK 155
+S+ + ++ W G+ LC +W++ D+ CCTASI ++ IALDRYW+IT +EY+ R
Sbjct: 94 ISIAYTIT-HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTA 152
Query: 156 CVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCV 215
+ MIA+ WA+S IS+ PL + + E S+ + + SY ++ST GAFY+P +
Sbjct: 153 GHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVL 212
Query: 216 VLFVYWKIYKAAKFRV-------GSRKT----------NSVSPISEAVEV--KDSAKQPQ 256
++ +Y +IY+AA+ R+ G R T +S+ ++ ++ SA P
Sbjct: 213 LIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPL 272
Query: 257 MVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCD 314
V+ E +E++A ++GI++G F++CW+PFF+ L+ P+C SC
Sbjct: 273 FFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCW 332
Query: 315 IPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
I F WLGY NS NP+IYT FN+ + AF+
Sbjct: 333 IHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQ 368
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 206 bits (523), Expect = 3e-53
Identities = 118/343 (34%), Positives = 188/343 (54%), Gaps = 27/343 (7%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
+LI L + T NL V+ I + H+ + L+ S+AV+D+LVA LVMPLS+++
Sbjct: 23 MLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIY 82
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
+ R W+LG LC++W++ D+ CCT SI ++ IALDRYW+IT +EY + + +
Sbjct: 83 IVMDR-WKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAAL 141
Query: 161 MIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE-PSYAVFSTVGAFYLPLCVVLFV 219
MI W +S IS+ PL + S +C + + Y ++ST+GAFY+PL ++L +
Sbjct: 142 MILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILIL 201
Query: 220 YWKIYKAAKF---------RVGSRKTNSVS-----PISEAVEVKD-SAKQPQMVFTVRHA 264
Y++IY AAK + +R T+S + +++ V D S P F HA
Sbjct: 202 YYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHA 261
Query: 265 TVTFQP---------EGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDI 315
++ P E +E++AA ++G+++G F+L W+PFF+ ELI L +
Sbjct: 262 SIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTV 321
Query: 316 PAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF-SRQH 357
+ WLGY NS NPL+YT+FN+++ AFK R+H
Sbjct: 322 SSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREH 364
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 204 bits (519), Expect = 1e-52
Identities = 120/335 (35%), Positives = 189/335 (56%), Gaps = 31/335 (9%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
V+I ++L + T A N LV+ ++ V+ + + L+ S+A++D+ VA VMP V
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSN 159
+L G +W G C ++IA DV+CCTASI + I++DRY ITR + Y +R KC++
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 160 VMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219
MI W LSA I+L P LFGW + ++ + C +S++ Y ++ST AFY+P+ V+LF+
Sbjct: 202 -MILSVWLLSASITLPP-LFGWAQNVND-DKVCLISQDFGYTIYSTAVAFYIPMSVMLFM 258
Query: 220 YWKIYKAAKFRVGSRK--------TNSVSPISEAV----EVKDSAKQPQMVFTVRHATVT 267
Y++IYKAA+ K +SV ++ V EV++ A +++ R
Sbjct: 259 YYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISI 318
Query: 268 FQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL-----CSCDIPAIWKSI 322
F ++EQ+AA +GI++G F +CW+PFFL P CSC IP +
Sbjct: 319 F---------KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERT 368
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
FLWLGY+NS NP IY FN++ + +++ Q+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 204 bits (519), Expect = 1e-52
Identities = 120/335 (35%), Positives = 189/335 (56%), Gaps = 31/335 (9%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
V+I ++L + T A N LV+ ++ V+ + + L+ S+A++D+ VA VMP V
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSN 159
+L G +W G C ++IA DV+CCTASI + I++DRY ITR + Y +R KC++
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 160 VMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219
MI W LSA I+L P LFGW + ++ + C +S++ Y ++ST AFY+P+ V+LF+
Sbjct: 202 -MILSVWLLSASITLPP-LFGWAQNVND-DKVCLISQDFGYTIYSTAVAFYIPMSVMLFM 258
Query: 220 YWKIYKAAKFRVGSRK--------TNSVSPISEAV----EVKDSAKQPQMVFTVRHATVT 267
Y++IYKAA+ K +SV ++ V EV++ A +++ R
Sbjct: 259 YYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISI 318
Query: 268 FQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL-----CSCDIPAIWKSI 322
F ++EQ+AA +GI++G F +CW+PFFL P CSC IP +
Sbjct: 319 F---------KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERT 368
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
FLWLGY+NS NP IY FN++ + +++ Q+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 204 bits (519), Expect = 1e-52
Identities = 120/335 (35%), Positives = 189/335 (56%), Gaps = 31/335 (9%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
V+I ++L + T A N LV+ ++ V+ + + L+ S+A++D+ VA VMP V
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSN 159
+L G +W G C ++IA DV+CCTASI + I++DRY ITR + Y +R KC++
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 160 VMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219
MI W LSA I+L P LFGW + ++ + C +S++ Y ++ST AFY+P+ V+LF+
Sbjct: 202 -MILSVWLLSASITLPP-LFGWAQNVND-DKVCLISQDFGYTIYSTAVAFYIPMSVMLFM 258
Query: 220 YWKIYKAAKFRVGSRK--------TNSVSPISEAV----EVKDSAKQPQMVFTVRHATVT 267
Y++IYKAA+ K +SV ++ V EV++ A +++ R
Sbjct: 259 YYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISI 318
Query: 268 FQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL-----CSCDIPAIWKSI 322
F ++EQ+AA +GI++G F +CW+PFFL P CSC IP +
Sbjct: 319 F---------KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERT 368
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357
FLWLGY+NS NP IY FN++ + +++ Q+
Sbjct: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 197 bits (500), Expect = 2e-50
Identities = 127/407 (31%), Positives = 204/407 (50%), Gaps = 77/407 (18%)
Query: 13 STPSPLETN-HSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTF 71
S P+P ET ++ G D+ S + V+ LLG L+ N V+A I R+
Sbjct: 14 SPPAPFETGGNTTGISDVTVS------YQVITSLLLGTLIFCAVLGNACVVAAIALERSL 67
Query: 72 HRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWN 131
V + L+ S+AV+D++V+ LV+P++ ++++ + W LG+ C L+IA DVLCCT+SI +
Sbjct: 68 QNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK-WTLGQVTCDLFIALDVLCCTSSILH 126
Query: 132 VTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEE 191
+ AIALDRYW+IT ++Y + + +I+LTW + +IS+ P+L GW +
Sbjct: 127 LCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPML-GWRTPEDRSDPD 185
Query: 192 -CQVSREPSYAVFSTVGAFYLPLCVVLFVY--------WKIYKAAKF--RVGSRKTNSVS 240
C +S++ Y ++ST GAFY+PL ++L +Y ++I K K + G+ + S
Sbjct: 186 ACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGAS 245
Query: 241 PIS------------------------------------------EAVEV------KDSA 252
P E +EV K+
Sbjct: 246 PAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHL 305
Query: 253 KQPQMVFTVRHATVTFQPEGDTWREQK-------EQRAALMVGILIGVFVLCWIPFFLTE 305
P A +F+ + + E K E++ +GI++G F+LCW+PFF+
Sbjct: 306 PLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVA 365
Query: 306 LISPLC--SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
L+ P C SC +P + +I WLGYSNS NP+IY FNK++ +AFK
Sbjct: 366 LVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK 412
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 194 bits (494), Expect = 8e-50
Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)
Query: 18 LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77
L N S + +P +P+ +L+ +LG L+ N+LV+ ++ R H V H
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 78 LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
+ ++AV+D+L+ + V+P S + E+ G W GR C +W A DVLCCTASI + I++
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197
DRY ++ + Y + + + WALS VIS+ P LFGW + E CQ++ E
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
Query: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254
P Y +FS +G+FYLPL ++L +Y ++Y AK K+ + S++ +V
Sbjct: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
Query: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314
P + A + +E++AA +GI++G FVLCW+PFFL I
Sbjct: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
Query: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
P+ ++K +F WLGY NS NP+IY ++ + AF+N
Sbjct: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 194 bits (494), Expect = 8e-50
Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)
Query: 18 LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77
L N S + +P +P+ +L+ +LG L+ N+LV+ ++ R H V H
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 78 LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
+ ++AV+D+L+ + V+P S + E+ G W GR C +W A DVLCCTASI + I++
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197
DRY ++ + Y + + + WALS VIS+ P LFGW + E CQ++ E
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
Query: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254
P Y +FS +G+FYLPL ++L +Y ++Y AK K+ + S++ +V
Sbjct: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
Query: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314
P + A + +E++AA +GI++G FVLCW+PFFL I
Sbjct: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
Query: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
P+ ++K +F WLGY NS NP+IY ++ + AF+N
Sbjct: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 194 bits (494), Expect = 8e-50
Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)
Query: 18 LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77
L N S + +P +P+ +L+ +LG L+ N+LV+ ++ R H V H
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 78 LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
+ ++AV+D+L+ + V+P S + E+ G W GR C +W A DVLCCTASI + I++
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197
DRY ++ + Y + + + WALS VIS+ P LFGW + E CQ++ E
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
Query: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254
P Y +FS +G+FYLPL ++L +Y ++Y AK K+ + S++ +V
Sbjct: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
Query: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314
P + A + +E++AA +GI++G FVLCW+PFFL I
Sbjct: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
Query: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
P+ ++K +F WLGY NS NP+IY ++ + AF+N
Sbjct: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 194 bits (494), Expect = 8e-50
Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)
Query: 18 LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77
L N S + +P +P+ +L+ +LG L+ N+LV+ ++ R H V H
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 78 LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
+ ++AV+D+L+ + V+P S + E+ G W GR C +W A DVLCCTASI + I++
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197
DRY ++ + Y + + + WALS VIS+ P LFGW + E CQ++ E
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
Query: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254
P Y +FS +G+FYLPL ++L +Y ++Y AK K+ + S++ +V
Sbjct: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
Query: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314
P + A + +E++AA +GI++G FVLCW+PFFL I
Sbjct: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
Query: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
P+ ++K +F WLGY NS NP+IY ++ + AF+N
Sbjct: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 185 bits (469), Expect = 6e-47
Identities = 116/363 (31%), Positives = 194/363 (53%), Gaps = 43/363 (11%)
Query: 7 LTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATIL 66
L + + + P+ +N +L + D+ + + V G IL + N+LV+ ++
Sbjct: 20 LKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI--------VGNILVILSVA 71
Query: 67 RVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCT 126
R + + ++A++D+L++ V+P S E+ G W LGR C +W A DVLCCT
Sbjct: 72 CNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY-WVLGRIFCDIWAAVDVLCCT 130
Query: 127 ASIWNVTAIALDRYWSITRHMEY-TLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETY 185
ASI ++ AI++DRY + ++Y TL TR+ ++++ W LS VIS+ PLL GW E
Sbjct: 131 ASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV-WVLSTVISIGPLL-GWKEPA 188
Query: 186 SEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEA 245
+EC V+ EP YA+FS++G+FY+PL V+L +Y ++Y AK + + + +S +
Sbjct: 189 PNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNS 248
Query: 246 VEV-----------------KDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVG 288
E+ K P+ V+ ++ +E++AA +G
Sbjct: 249 KELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVK-----------LFKFSREKKAAKTLG 297
Query: 289 ILIGVFVLCWIPFFLTELISPLCSCDIP--AIWKSIFLWLGYSNSFFNPLIYTAFNKNYN 346
I++G+F+LCW+PFF+ + L S P A++K +F WLGY NS NP+IY +K +
Sbjct: 298 IVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF-WLGYFNSCLNPIIYPCSSKEFK 356
Query: 347 SAF 349
AF
Sbjct: 357 RAF 359
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 177 bits (450), Expect = 1e-44
Identities = 109/332 (32%), Positives = 174/332 (52%), Gaps = 26/332 (7%)
Query: 35 LLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVM 94
++S GV + L + A NLLV+ ++ R V + + ++AV+D+L++A V+
Sbjct: 91 VVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVL 150
Query: 95 PLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR 154
P S E+ G W GR C +W A DVLCCTASI ++ I++DRY + ++Y
Sbjct: 151 PFSATMEVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMT 209
Query: 155 KCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLC 214
+ + ++AL W ++ V+S+ PLL GW E C ++ E YAVFS+V +FYLP+
Sbjct: 210 ERKAAAILALLWVVALVVSVGPLL-GWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMA 268
Query: 215 VVLFVYWKIYKAAKFRVGS------RKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTF 268
V++ +Y ++Y A+ S R+ S + + + +A +R A
Sbjct: 269 VIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSA---- 324
Query: 269 QPEGDTWRE---------QKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPA-- 317
+G T+R +E++AA + I++GVFVLCW PFF + L P+
Sbjct: 325 --KGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEG 382
Query: 318 IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
++K IF WLGY NS NPLIY ++ + AF
Sbjct: 383 VFKVIF-WLGYFNSCVNPLIYPCSSREFKRAF 413
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 172 bits (437), Expect = 3e-43
Identities = 107/333 (32%), Positives = 170/333 (51%), Gaps = 33/333 (9%)
Query: 39 FGVLILT--LLGFLVAATFAWNLLVLATILRVRTFH-RVPHNLVASMAVSDVLVAALVMP 95
F V ILT L L+ +T N LV A ++R R +V + V S+AVSD+LVA LVMP
Sbjct: 20 FSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMP 79
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRK 155
V E++G W G C +W+A D++C TASI N+ I++DRYW+I+ Y +
Sbjct: 80 WKAVAEIAGF-WPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
Query: 156 CVSNVMIALTWALSAVISLAPLLFGW------------GETYSEGSEECQVSREPSYAVF 203
+ ++I++ W LS +IS P+ W + +E + C S +YA+
Sbjct: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
Query: 204 STVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRH 263
S+V +FY+P+ +++ Y +IY R+ ++ ++ + A AK Q
Sbjct: 198 SSVISFYIPVAIMIVTYTRIY-----RIAQKQIRRIAALERAAV---HAKNCQTTTGNGK 249
Query: 264 ATVTFQPEGD-TWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD------IP 316
QPE ++E + + +++GVFV CW+PFF+ I P C I
Sbjct: 250 PVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCID 309
Query: 317 AIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
+ +F+W G++NS NP+IY AFN ++ AF
Sbjct: 310 SNTFDVFVWFGWANSSLNPIIY-AFNADFRKAF 341
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 168 bits (426), Expect = 6e-42
Identities = 109/332 (32%), Positives = 170/332 (51%), Gaps = 31/332 (9%)
Query: 50 LVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQL 109
L+ A N LV +L+ R + LV S+AV+D+LVA LVMP + E++G W
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 110 GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN---VMIALTW 166
R C +++ DV+ CTASI N+ AI++DRY ++ + Y T + +MI W
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 167 ALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKA 226
L+ +S PLLFG+ T C +S P + ++S+V +FYLP V + VY +IY
Sbjct: 159 VLAFAVS-CPLLFGFNTT--GDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
Query: 227 AK----FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVT---------FQPE-G 272
K R+ +R+ + + + + + P + R+ ++ FQ G
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
Query: 273 DTWREQK---------EQRAALMVGILIGVFVLCWIPFFLTELISPLC-SCDIPAIWKSI 322
+ RE+K E++A MV I++G F++CW+PFFLT +++ C +C + S
Sbjct: 275 ELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA 334
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFS 354
WLGY NS NP+IYT FN + AF S
Sbjct: 335 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILS 366
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 166 bits (421), Expect = 2e-41
Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 58/364 (15%)
Query: 33 SPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNL-VASMAVSDVLVAA 91
+P L V+ LL L+ T N+LV A I+R R N+ + S+AVSD+ VA
Sbjct: 33 APPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVAL 92
Query: 92 LVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTL 151
LVMP V E++G W G C +W+A D++C TASI N+ I++DRYW+I+R Y
Sbjct: 93 LVMPWKAVAEVAGY-WPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKR 150
Query: 152 RTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEG----------------------- 188
+ + ++ VM+ L W LS +IS P+ W +
Sbjct: 151 KMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEP 210
Query: 189 ---SEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEA 245
+E C S +YA+ S++ +FY+P+ +++ Y +IY+ A+ ++ +S + A
Sbjct: 211 DVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQI-----RRISSLERA 265
Query: 246 VEVKDSAKQPQMVF--TVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFL 303
E S + T A++ +KE + + +++GVFV CW+PFF+
Sbjct: 266 AEHAQSCRSSAACAPDTSLRASI-----------KKETKVLKTLSVIMGVFVCCWLPFFI 314
Query: 304 TELISPLCS-------CDIPAIWKS---IFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFF 353
+ P CS P + ++ +F+W G++NS NP+IY AFN ++ F
Sbjct: 315 LNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIY-AFNADFQKVFAQLL 373
Query: 354 SRQH 357
H
Sbjct: 374 GCSH 377
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 165 bits (418), Expect = 5e-41
Identities = 99/316 (31%), Positives = 160/316 (50%), Gaps = 16/316 (5%)
Query: 43 ILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHEL 102
+ L ++A T A N L++A I + + S+ SD++V +VMP ++++ L
Sbjct: 29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
Query: 103 SGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMI 162
GR W L R LC LW A DV+CC+ASI N+ I+LDRY I + Y LR + ++
Sbjct: 89 YGR-WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALV 147
Query: 163 ALTWALSAVISLAPLLFGW---GETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219
W+L+A+ S PLL GW G +C++ + + ++ F+LP + F
Sbjct: 148 LGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFT 207
Query: 220 YWKIYKAAK---FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWR 276
Y +I AA+ +V S T S SE ++V + + R T
Sbjct: 208 YCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLA--------TKH 259
Query: 277 EQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPL 336
+K +A+L +GIL+G+F + W+PFF+ ++ +C C P ++ + WLGY NS NP+
Sbjct: 260 SRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLF-DVLTWLGYCNSTMNPI 318
Query: 337 IYTAFNKNYNSAFKNF 352
IY F +++ A F
Sbjct: 319 IYPLFMRDFKRALGRF 334
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 159 bits (402), Expect = 4e-39
Identities = 99/329 (30%), Positives = 161/329 (48%), Gaps = 28/329 (8%)
Query: 46 LLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR 105
L+ +V A N+LV+ I + + + + S+A +D+++ LV+P + GR
Sbjct: 64 LMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGR 123
Query: 106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALT 165
W+ G C+LW + DVLC TASI + IALDRY +IT Y + + ++
Sbjct: 124 -WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTV 182
Query: 166 WALSAVISLAPLLFGWGETYSEGSEE-------CQVSREPSYAVFSTVGAFYLPLCVVLF 218
WA+SA++S P+L W S+ + C +YA+ S+V +FY+PLC++ F
Sbjct: 183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAF 242
Query: 219 VYWKIYKAAKFRVGSRKTNSVS----------PISEAVEVKDSAKQPQMVFTVRHATVTF 268
VY ++++ A+ +V +K +S P V A P A
Sbjct: 243 VYLRVFREAQKQV--KKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP 300
Query: 269 QPEGDTWREQ-------KEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKS 321
G + + +EQ+A +GI++GVF LCW+PFFL ++ +P
Sbjct: 301 LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV 360
Query: 322 IFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
F WLGY+NS FNP+IY + ++ AF+
Sbjct: 361 FFNWLGYANSAFNPIIYCR-SPDFRKAFQ 388
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 157 bits (397), Expect = 1e-38
Identities = 105/337 (31%), Positives = 175/337 (51%), Gaps = 28/337 (8%)
Query: 34 PLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALV 93
P LS+ ++I+T+ G N+LV+ + + H + + S+A++D+LV LV
Sbjct: 56 PALSIVIIIIMTIGG---------NILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLV 106
Query: 94 MPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRT 153
MPLSL+ L W L R LC +WI+ DVL TASI ++ AI+LDRY +I +E++
Sbjct: 107 MPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFN 166
Query: 154 RKCVSNVMIALTWALSAVISLAPLLFGW--GETYSEGSEECQVSREPSYAVFSTVGAFYL 211
+ + + IA+ WA+S +S+ + G E + C V +P++ + + AF++
Sbjct: 167 SRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC-VLNDPNFVLIGSFVAFFI 225
Query: 212 PLCVVLFVY-WKIYKAAKFRVGSRKTNSVSPIS-----------EAVEVKDSAKQPQMVF 259
PL +++ Y IY + + ++ P E ++SA Q
Sbjct: 226 PLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQN 285
Query: 260 TVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SCDIPA 317
R +P G E++A+ ++GI+ VF++ W PFF+T ++S LC SC+
Sbjct: 286 ARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKL 345
Query: 318 IWK--SIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNF 352
+ K ++F+W+GY S NPL+YT FNK Y AF N+
Sbjct: 346 MEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 382
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 156 bits (394), Expect = 3e-38
Identities = 101/327 (30%), Positives = 155/327 (47%), Gaps = 24/327 (7%)
Query: 46 LLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR 105
LL V AT NLLV+ I + + V S+A +D+++ LV+P + L+G
Sbjct: 43 LLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH 102
Query: 106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALT 165
W LG C+LW + DVLC TASI + A+A+DRY ++T + Y K + + L
Sbjct: 103 -WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLV 161
Query: 166 WALSAVISLAPLLFGWGETYSEGSEE--------CQVSREPSYAVFSTVGAFYLPLCVVL 217
W +SA +S AP++ W ++ + C + Y + S+ +FYLPL V+L
Sbjct: 162 WVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVML 221
Query: 218 FVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEG----- 272
FVY ++ F V +R+ + ++S P PEG
Sbjct: 222 FVYARV-----FVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACG 276
Query: 273 ---DTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD-IPAIWKSIFLWLGY 328
+E RA +G+++G F LCW+PFFL ++ L +P WLGY
Sbjct: 277 RRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGY 336
Query: 329 SNSFFNPLIYTAFNKNYNSAFKNFFSR 355
+NS FNPLIY + ++ SAF+ R
Sbjct: 337 ANSAFNPLIYCR-SPDFRSAFRRLLCR 362
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 155 bits (393), Expect = 4e-38
Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 64/365 (17%)
Query: 50 LVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQL 109
L+ A N LV +L+ R + LV S+AV+D+LVA LVMP + E++G W
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 110 GRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN---VMIALTW 166
R C +++ DV+ CTASI N+ AI++DRY ++ + Y T + +MI W
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 167 ALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKA 226
L+ +S PLLFG+ T C +S P + ++S+V +FYLP V + VY +IY
Sbjct: 159 VLAFAVS-CPLLFGFNTT--GDPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVV 214
Query: 227 AK----FRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVT---------FQPE-G 272
K R+ +R+ + + + + + P + R+ ++ FQ G
Sbjct: 215 LKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGG 274
Query: 273 DTWREQK------------------------------------------EQRAALMVGIL 290
+ RE+K E++A MV I+
Sbjct: 275 ELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIV 334
Query: 291 IGVFVLCWIPFFLTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF 349
+G F++CW+PFFLT +++ C +C + S WLGY NS NP+IYT FN + AF
Sbjct: 335 LGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAF 394
Query: 350 KNFFS 354
S
Sbjct: 395 LKILS 399
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 155 bits (392), Expect = 5e-38
Identities = 93/324 (28%), Positives = 169/324 (52%), Gaps = 16/324 (4%)
Query: 46 LLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR 105
L ++ T A N+LV+ + + + + S+A++D+L+ LVMP+S++ L G
Sbjct: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139
Query: 106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALT 165
RW L +LC +WI DVL TASI ++ AI+LDRY +I + ++ + + + I
Sbjct: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAV 199
Query: 166 WALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYK 225
W +S IS+ +FG + E + + ++ + + +F++PL +++ Y+ K
Sbjct: 200 WTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIK 259
Query: 226 AAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFT---VRHATVTFQPEGDTWRE----- 277
+ + T VS + ++ + PQ + + ++ +P T R
Sbjct: 260 SLQ----KEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSI 315
Query: 278 QKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SC--DIPAIWKSIFLWLGYSNSFF 333
EQ+A ++GI+ +FV+ W PFF+T +++ +C SC D+ ++F+W+GY +S
Sbjct: 316 SNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAV 375
Query: 334 NPLIYTAFNKNYNSAFKNFFSRQH 357
NPL+YT FNK Y SAF + Q+
Sbjct: 376 NPLVYTLFNKTYRSAFSRYIQCQY 399
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 150 bits (379), Expect = 2e-36
Identities = 85/319 (26%), Positives = 159/319 (49%), Gaps = 40/319 (12%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
+ I +L L+ T A N++V + R + + + S+A++D+L+ LV+P S ++
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
+LS + W G+ C ++ + DV+ CTASI N+ I+LDRY ++ + Y + +
Sbjct: 79 QLSCK-WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 161 MIALTWALSAVISLAPLLFGWG--ETYSEG---SEECQVSREPSYAVFSTVGAFYLPLCV 215
+ L W +S +S + GW S+G + +C+V Y + + FYLPL +
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLI 197
Query: 216 VLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTW 275
+ Y++I+K A +D AK+ + + + AT+
Sbjct: 198 MCITYYRIFKVA---------------------RDQAKRINHISSWKAATI--------- 227
Query: 276 REQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD-IPAIWKSIFLWLGYSNSFFN 334
+E +A + + ++G F++CW P+F + L D I + ++I LWLGY+NS N
Sbjct: 228 ---REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALN 284
Query: 335 PLIYTAFNKNYNSAFKNFF 353
P++Y A N+++ + ++ F
Sbjct: 285 PILYAALNRDFRTGYQQLF 303
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 150 bits (379), Expect = 2e-36
Identities = 85/319 (26%), Positives = 159/319 (49%), Gaps = 40/319 (12%)
Query: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100
+ I +L L+ T A N++V + R + + + S+A++D+L+ LV+P S ++
Sbjct: 19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIY 78
Query: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNV 160
+LS + W G+ C ++ + DV+ CTASI N+ I+LDRY ++ + Y + +
Sbjct: 79 QLSCK-WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137
Query: 161 MIALTWALSAVISLAPLLFGWG--ETYSEG---SEECQVSREPSYAVFSTVGAFYLPLCV 215
+ L W +S +S + GW S+G + +C+V Y + + FYLPL +
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLI 197
Query: 216 VLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTW 275
+ Y++I+K A +D AK+ + + + AT+
Sbjct: 198 MCITYYRIFKVA---------------------RDQAKRINHISSWKAATI--------- 227
Query: 276 REQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD-IPAIWKSIFLWLGYSNSFFN 334
+E +A + + ++G F++CW P+F + L D I + ++I LWLGY+NS N
Sbjct: 228 ---REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALN 284
Query: 335 PLIYTAFNKNYNSAFKNFF 353
P++Y A N+++ + ++ F
Sbjct: 285 PILYAALNRDFRTGYQQLF 303
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 147 bits (371), Expect = 1e-35
Identities = 96/327 (29%), Positives = 153/327 (46%), Gaps = 33/327 (10%)
Query: 37 SVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN-LVASMAVSDVLVAALVMP 95
SV V++LT L ++ NLLV+ + R ++ N + S+A +D+LV+ LVMP
Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSIT-RHMEYTLRTR 154
+ EL W G C + + DVL TASI+++ I+LDRY++I + + Y +
Sbjct: 76 FGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 155 KCVSNVMIALTWALSAVISLAPLLFGWGE------------TYSEGSEECQVSREPSYAV 202
+M+ W + IS P++ GW + S C YA+
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 203 FSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVR 262
+V AFY+P +++ Y++IY AK + + + A +S Q
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAK-----EHAHQIQMLQRAGASSESRPQSA------ 243
Query: 263 HATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSI 322
+ T R + E +AA + I++G F LCW PFF+T ++ P +P +
Sbjct: 244 -------DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA 296
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAF 349
FLWLGY NS NP +Y NK++ AF
Sbjct: 297 FLWLGYINSGLNPFLYAFLNKSFRRAF 323
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 147 bits (371), Expect = 1e-35
Identities = 96/327 (29%), Positives = 153/327 (46%), Gaps = 33/327 (10%)
Query: 37 SVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN-LVASMAVSDVLVAALVMP 95
SV V++LT L ++ NLLV+ + R ++ N + S+A +D+LV+ LVMP
Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSIT-RHMEYTLRTR 154
+ EL W G C + + DVL TASI+++ I+LDRY++I + + Y +
Sbjct: 76 FGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 155 KCVSNVMIALTWALSAVISLAPLLFGWGE------------TYSEGSEECQVSREPSYAV 202
+M+ W + IS P++ GW + S C YA+
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 203 FSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVR 262
+V AFY+P +++ Y++IY AK + + + A +S Q
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAK-----EHAHQIQMLQRAGASSESRPQSA------ 243
Query: 263 HATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSI 322
+ T R + E +AA + I++G F LCW PFF+T ++ P +P +
Sbjct: 244 -------DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA 296
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAF 349
FLWLGY NS NP +Y NK++ AF
Sbjct: 297 FLWLGYINSGLNPFLYAFLNKSFRRAF 323
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 147 bits (371), Expect = 1e-35
Identities = 96/327 (29%), Positives = 153/327 (46%), Gaps = 33/327 (10%)
Query: 37 SVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN-LVASMAVSDVLVAALVMP 95
SV V++LT L ++ NLLV+ + R ++ N + S+A +D+LV+ LVMP
Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSIT-RHMEYTLRTR 154
+ EL W G C + + DVL TASI+++ I+LDRY++I + + Y +
Sbjct: 76 FGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 155 KCVSNVMIALTWALSAVISLAPLLFGWGE------------TYSEGSEECQVSREPSYAV 202
+M+ W + IS P++ GW + S C YA+
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 203 FSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVR 262
+V AFY+P +++ Y++IY AK + + + A +S Q
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAK-----EHAHQIQMLQRAGASSESRPQSA------ 243
Query: 263 HATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSI 322
+ T R + E +AA + I++G F LCW PFF+T ++ P +P +
Sbjct: 244 -------DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA 296
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAF 349
FLWLGY NS NP +Y NK++ AF
Sbjct: 297 FLWLGYINSGLNPFLYAFLNKSFRRAF 323
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 147 bits (371), Expect = 1e-35
Identities = 96/327 (29%), Positives = 153/327 (46%), Gaps = 33/327 (10%)
Query: 37 SVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN-LVASMAVSDVLVAALVMP 95
SV V++LT L ++ NLLV+ + R ++ N + S+A +D+LV+ LVMP
Sbjct: 16 SVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMP 75
Query: 96 LSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSIT-RHMEYTLRTR 154
+ EL W G C + + DVL TASI+++ I+LDRY++I + + Y +
Sbjct: 76 FGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 155 KCVSNVMIALTWALSAVISLAPLLFGWGE------------TYSEGSEECQVSREPSYAV 202
+M+ W + IS P++ GW + S C YA+
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 203 FSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVR 262
+V AFY+P +++ Y++IY AK + + + A +S Q
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAK-----EHAHQIQMLQRAGASSESRPQSA------ 243
Query: 263 HATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSI 322
+ T R + E +AA + I++G F LCW PFF+T ++ P +P +
Sbjct: 244 -------DQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA 296
Query: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAF 349
FLWLGY NS NP +Y NK++ AF
Sbjct: 297 FLWLGYINSGLNPFLYAFLNKSFRRAF 323
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.136 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,901,386
Number of Sequences: 37866
Number of extensions: 525843
Number of successful extensions: 3031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 230
Number of HSP's that attempted gapping in prelim test: 2040
Number of HSP's gapped (non-prelim): 792
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.