BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] (432 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 878 0.0 gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 878 0.0 gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 878 0.0 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 226 3e-59 gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 224 2e-58 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 220 2e-57 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 220 2e-57 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 220 2e-57 gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 220 2e-57 gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 220 2e-57 gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 219 4e-57 gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 215 7e-56 gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 214 2e-55 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 213 4e-55 gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 204 1e-52 gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 196 3e-50 gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 195 8e-50 gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 195 8e-50 gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 195 8e-50 gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 195 8e-50 gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 195 8e-50 gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 195 8e-50 gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 191 8e-49 gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 189 3e-48 gi|4503383 dopamine receptor D1 [Homo sapiens] 187 2e-47 gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 184 2e-46 gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 184 2e-46 gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 184 2e-46 gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 177 2e-44 gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 177 2e-44 >gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] Length = 432 Score = 878 bits (2269), Expect = 0.0 Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 Query: 421 LAERPERPEFVL 432 LAERPERPEFVL Sbjct: 421 LAERPERPEFVL 432 >gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] Length = 479 Score = 878 bits (2269), Expect = 0.0 Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 Query: 421 LAERPERPEFVL 432 LAERPERPEFVL Sbjct: 421 LAERPERPEFVL 432 >gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] Length = 445 Score = 878 bits (2269), Expect = 0.0 Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW Sbjct: 1 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 60 Query: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI Sbjct: 61 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 120 Query: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR Sbjct: 121 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180 Query: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT Sbjct: 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 240 Query: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE Sbjct: 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 300 Query: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC Sbjct: 301 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 360 Query: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK Sbjct: 361 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 420 Query: 421 LAERPERPEFVL 432 LAERPERPEFVL Sbjct: 421 LAERPERPEFVL 432 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 226 bits (576), Expect = 3e-59 Identities = 124/341 (36%), Positives = 197/341 (57%), Gaps = 26/341 (7%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 + +G +L L I GN LV++SV + LR P+NY IV+LA+ADL ++ V+PF + Sbjct: 46 ISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAAL 105 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W+ G FC+++ A+DV+CCTASI++LC ISIDRY+G+ L YP + Sbjct: 106 EVLG-YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164 Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 +LSVW+LS I++ PL GW + NDDK C ++++ Y ++S+ +FYIP++V+L MY Sbjct: 165 ALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYC 224 Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI- 318 ++Y A+++ + + + L + + E+ + ++ H R +I++ Sbjct: 225 RVYIVAKRTTKNLEAGVMKEMSNSKELTLR--IHSKNFHEDTLSSTKAKGHNPRSSIAVK 282 Query: 319 ---FKREQKAATTLGIIVGAFTVCWLPFF-------LLSTARPFICGTSCSCIPLWVERT 368 F RE+KAA TLGI+VG F +CWLPFF L ST +P P V + Sbjct: 283 LFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP----------PDAVFKV 332 Query: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409 WLGY NS +NP IY +++ + + +L CQ R R+ Sbjct: 333 VFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRR 373 >gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sapiens] Length = 422 Score = 224 bits (570), Expect = 2e-58 Identities = 138/419 (32%), Positives = 218/419 (52%), Gaps = 74/419 (17%) Query: 50 SEVTASPAPTWDAPPDNASGCGE-QINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCF 108 + T+ PAP N +G + ++Y + +++G+++ + GN VV ++ Sbjct: 10 NNTTSPPAPFETG--GNTTGISDVTVSYQVITSLLLGTLI----FCAVLGNACVVAAIAL 63 Query: 109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTA 168 + L+ +NYLI SLA+ DL V+V V+P ++ ++ KW G C++FIA+DV+CCT+ Sbjct: 64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTS 122 Query: 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVN 226 SI+ LC I++DRY IT P+ Y ++ + A +I WL+ I++PP+ GW ++ + Sbjct: 123 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRS 182 Query: 227 DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR-----------KSAAKHKF 275 D C IS+D GYTIYST AFYIP+ +ML +Y +I++AAR K+ A + Sbjct: 183 DPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRH 242 Query: 276 PGFPRVEP---------------------DSVIALNGIVK-----LQKEVEE-------- 301 P +P + NG V+ EV E Sbjct: 243 GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK 302 Query: 302 -------------CANLSRLLKHER----KNISIFKREQKAATTLGIIVGAFTVCWLPFF 344 CA S K+ER K RE+K TLGII+G F +CWLPFF Sbjct: 303 EHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFF 362 Query: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403 +++ PF C +SC +P + WLGY+NSL+NP IYA+FN+D + ++ +++C++ Sbjct: 363 IVALVLPF-CESSCH-MPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 220 bits (561), Expect = 2e-57 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 +++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++ Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP + Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145 Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 +L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205 Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319 ++Y A++ + K G + DS I + S K H + F Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264 Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379 RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321 Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402 NP IY +++ + ++++L+ Q Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 220 bits (561), Expect = 2e-57 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 +++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++ Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP + Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145 Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 +L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205 Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319 ++Y A++ + K G + DS I + S K H + F Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264 Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379 RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321 Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402 NP IY +++ + ++++L+ Q Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 220 bits (561), Expect = 2e-57 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 +++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++ Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP + Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145 Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 +L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205 Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319 ++Y A++ + K G + DS I + S K H + F Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264 Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379 RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321 Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402 NP IY +++ + ++++L+ Q Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 >gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] Length = 429 Score = 220 bits (561), Expect = 2e-57 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 +++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++ Sbjct: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP + Sbjct: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145 Query: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 +L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205 Query: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319 ++Y A++ + K G + DS I + S K H + F Sbjct: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264 Query: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379 RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321 Query: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402 NP IY +++ + ++++L+ Q Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 >gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sapiens] Length = 366 Score = 220 bits (560), Expect = 2e-57 Identities = 129/349 (36%), Positives = 191/349 (54%), Gaps = 33/349 (9%) Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140 K+++ L+ + L+T N LV+ ++ +KL P+NYLI SLA+ D VAV VMPF S+ Sbjct: 23 KILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SI 81 Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200 ++ WI G C++++++D+ CCT SI+ L I++DRY IT + Y ++ K Sbjct: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141 Query: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLFMY 259 MI VW++S I++PPLF Q + D C+I D TIYST AFYIP++++L +Y Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201 Query: 260 YQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL---------- 309 Y+IY+AA+ K + + E + + L K K V L + L Sbjct: 202 YKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKI 261 Query: 310 -----------KHE----RKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIC 354 KHE R+ IS RE+KAATTLG+I+GAF +CWLPFF+ + + Sbjct: 262 HSTVRSLRSEFKHEKSWRRQKIS-GTRERKAATTLGLILGAFVICWLPFFV----KELVV 316 Query: 355 GTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402 C I + WLGY NSLINP IY FN D + ++ L++C+ Sbjct: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365 >gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sapiens] Length = 377 Score = 219 bits (558), Expect = 4e-57 Identities = 134/344 (38%), Positives = 188/344 (54%), Gaps = 35/344 (10%) Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140 K+ + +L++ITL T+ N V+ ++ +KL P+NYLI SLA DL V++ VMP +S+ Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMP-ISI 96 Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200 I W FG C+++++ D+ CCTASI+ LCVI++DRY IT L Y R+ A Sbjct: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156 Query: 201 KMILSVWLLSASITLPPLFGWAQNVNDDKV--CLI-SQDFGYTIYSTAVAFYIPMSVMLF 257 MI VW +S I++PPLF W Q +++ CL+ + YTIYST AFYIP +++ Sbjct: 157 TMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLII 215 Query: 258 MYYQIYKAAR------------KSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANL 305 +Y +IY+AAR + H G S+ +LN L + A Sbjct: 216 LYGRIYRAARNRILNPPSLYGKRFTTAHLITG---SAGSSLCSLNS--SLHEGHSHSAGS 270 Query: 306 SRLLKH----------ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG 355 H ERK IS RE+KA LGII+GAF +CWLPFF++S P IC Sbjct: 271 PLFFNHVKIKLADSALERKRISA-ARERKATKILGIILGAFIICWLPFFVVSLVLP-ICR 328 Query: 356 TSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399 SC P + F WLGY NSLINP IY FN + R ++ ++ Sbjct: 329 DSCWIHPALFD-FFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371 >gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sapiens] Length = 390 Score = 215 bits (547), Expect = 7e-56 Identities = 141/387 (36%), Positives = 206/387 (53%), Gaps = 38/387 (9%) Query: 39 PVAGS--WAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTI 96 P AGS W P + S AP+ + +A Q + KV++ +L LITL T Sbjct: 12 PPAGSETWVP----QANLSSAPSQNC---SAKDYIYQDSISLPWKVLLVMLLALITLATT 64 Query: 97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN 156 N V+ +V +KL P+NYLI SLA+ DL V++ VMP +S + G+W G C+ Sbjct: 65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMP-ISTMYTVTGRWTLGQVVCD 123 Query: 157 VFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216 +++ D+ CCTASI+ LCVI++DRY IT + Y ++ K A MI VW+ S SI+LP Sbjct: 124 FWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP 183 Query: 217 PLFGWAQNVNDDKV--CLISQD-FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH 273 P F W Q +++V C+++ D YT+YST AFY P +++ +Y +IY AR K Sbjct: 184 PFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQ 242 Query: 274 ------KFPGFPRVEPDSVIALNGIVKLQKEVEEC--------------ANLSRLLKHER 313 K ++ DS + + + + V + +S L ++ Sbjct: 243 TPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKK 302 Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373 K ++ RE+KA TLGII+GAF VCWLPFF++S P IC +C L + F WLG Sbjct: 303 KLMA--ARERKATKTLGIILGAFIVCWLPFFIISLVMP-ICKDAC-WFHLAIFDFFTWLG 358 Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQ 400 Y NSLINP IY N D + + L++ Sbjct: 359 YLNSLINPIIYTMSNEDFKQAFHKLIR 385 >gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sapiens] Length = 365 Score = 214 bits (544), Expect = 2e-55 Identities = 135/352 (38%), Positives = 192/352 (54%), Gaps = 39/352 (11%) Query: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139 EK++I L +IT LT N V++++ KKL QP+NYLI SLA+ DL VAV VMP +S Sbjct: 21 EKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP-LS 79 Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199 + ++ +W G+F C V++++D+ CCT SI+ LCVI++DRY IT + Y ++ K Sbjct: 80 IIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRA 139 Query: 200 AKMILSVWLLSASITLPPLFGWAQNVN---DDKVCLISQDFG-YTIYSTAVAFYIPMSVM 255 A MIL+VW +S I++PPLF W + C I D YTIYST AFYIP++++ Sbjct: 140 ALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLI 198 Query: 256 LFMYYQIYKAARKSAAKHKFPGFPR-VEPDSVIALNGIVKLQKEVEECAN---------- 304 L +YY+IY AA+ K G R + S + N + C + Sbjct: 199 LILYYRIYHAAKSLYQKR---GSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTE 255 Query: 305 ------------LSRLLKH--ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTAR 350 L H ER+ IS RE+KAA LG+I+GAF + WLPFF+ + Sbjct: 256 FEKFHASIRIPPFDNDLDHPGERQQIS-STRERKAARILGLILGAFILSWLPFFI----K 310 Query: 351 PFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402 I G S + V WLGY NSLINP +Y FN D + ++ L++C+ Sbjct: 311 ELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR 362 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 213 bits (541), Expect = 4e-55 Identities = 134/396 (33%), Positives = 213/396 (53%), Gaps = 17/396 (4%) Query: 22 PEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK 81 P VG G+P + GG AGS + S A A+ G ++ + Sbjct: 41 PAVG-GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS---AQG 96 Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 V +G L L+ +AGN LV++SV + L+ +NY IV+LA+ADL ++ V+PF + Sbjct: 97 VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +++G W FG FC+V+ A+DV+CCTASI++LC IS+DRY+G+ L YP + A Sbjct: 157 EVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAA 215 Query: 202 MILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260 ++ +W+++ +++ PL GW + V D++ C I+++ GY ++S+ +FY+PM+V++ MY Sbjct: 216 ILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275 Query: 261 QIYKAARKSAAKHKFPGFPRVEPD-SVIALNGIVKLQKEVEECANLSRLLKHE--RKNIS 317 ++Y AR S + G R S + L + + A+ R K R ++S Sbjct: 276 RVYVVAR-STTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS 334 Query: 318 I----FKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373 + F RE+KAA TL I+VG F +CW PFF + S V + WLG Sbjct: 335 VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPS---EGVFKVIFWLG 391 Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRK 409 Y NS +NP IY +R+ + + LL+CQ R R+ Sbjct: 392 YFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427 >gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] Length = 357 Score = 204 bits (519), Expect = 1e-52 Identities = 120/335 (35%), Positives = 189/335 (56%), Gaps = 31/335 (9%) Query: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141 V+I ++L + T A N LV+ ++ V+ + + L+ S+A++D+ VA VMP V Sbjct: 41 VLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVH 100 Query: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201 +L G +W G C ++IA DV+CCTASI + I++DRY ITR + Y +R KC++ Sbjct: 101 ELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSN 159 Query: 202 -MILSVWLLSASITLPP-LFGWAQNVND-DKVCLISQDFGYTIYSTAVAFYIPMSVMLFM 258 MI W LSA I+L P LFGW + ++ + C +S++ Y ++ST AFY+P+ V+LF+ Sbjct: 160 VMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFV 219 Query: 259 YYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISI 318 Y++IYKAA+ K +SV ++ V EV++ A +++ R Sbjct: 220 YWKIYKAAKFRVGSRK--------TNSVSPISEAV----EVKDSAKQPQMVFTVRHATVT 267 Query: 319 F---------KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVERT 368 F ++EQ+AA +GI++G F +CW+PFFL P CSC IP + Sbjct: 268 FQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPL-----CSCDIPAIWKSI 322 Query: 369 FLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQY 403 FLWLGY+NS NP IY FN++ + +++ Q+ Sbjct: 323 FLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357 >gi|4557265 beta-1-adrenergic receptor [Homo sapiens] Length = 477 Score = 196 bits (498), Expect = 3e-50 Identities = 124/352 (35%), Positives = 185/352 (52%), Gaps = 27/352 (7%) Query: 84 IGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143 +G ++ LI LL +AGN LV++++ +L+ +N I+SLA ADL + + V+PF T + Sbjct: 61 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF-GATIV 119 Query: 144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI 203 + G+W +G FFC ++ ++DV+C TASI TLCVI++DRYL IT P Y ++ Sbjct: 120 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179 Query: 204 LSVWLLSASIT-LPPLFGW--------AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254 +VW +SA ++ LP L W + ND K C + Y I S+ V+FY+P+ + Sbjct: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCI 239 Query: 255 MLFMYYQIYKAARKSAAK-----HKFPGFPRVEPD---SVIALNGIVKLQKEVEECANLS 306 M F+Y ++++ A+K K +F G P P S + A + Sbjct: 240 MAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATA 299 Query: 307 RLLK----HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362 L R + + REQKA TLGII+G FT+CWLPFFL + + F +P Sbjct: 300 PLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAF----HRELVP 355 Query: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAG 414 + F WLGYANS NP IY + D R ++ LL C R R+ + G Sbjct: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAARRRHATHG 406 >gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] Length = 359 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] Length = 428 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] Length = 360 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] Length = 387 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] Length = 378 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] Length = 388 Score = 195 bits (495), Expect = 8e-50 Identities = 128/349 (36%), Positives = 184/349 (52%), Gaps = 42/349 (12%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT-RPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGWAQ------------NVNDDKV-CLISQDFGY 239 +A M+ W++ I+ LP + GW N N + C+ + Y Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPY 192 Query: 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEV 299 I + VAFYIP +M+ YY+IY A++ A H+ R S Sbjct: 193 AITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGASSE------------- 237 Query: 300 EECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCS 359 SR ++ + + E KAA TL II+G F +CW PFF+ + PFI T Sbjct: 238 ------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT--- 288 Query: 360 CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408 +P V FLWLGY NS +NPF+YAF N+ R + +L C R Sbjct: 289 -VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRR 336 >gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] Length = 367 Score = 191 bits (486), Expect = 8e-49 Identities = 122/339 (35%), Positives = 179/339 (52%), Gaps = 38/339 (11%) Query: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150 + L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 Query: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207 C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 Query: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267 +L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY + Sbjct: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216 Query: 268 KSAAKHKF-----------PGFPR--VEPDSVIALNGIVKLQKEVEECANLS-------- 306 + K PGFP+ + PD ++L++ C + + Sbjct: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDP-----AHLELKRYYSICQDTALGGPGFQE 271 Query: 307 ---RLLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIP 362 L + E+ S+ RE+KA + I++GAF VCWLPFFL C T C P Sbjct: 272 RGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTH-CQT-CHVSP 329 Query: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401 T WLGY NS +NP IY FN + R + +L C Sbjct: 330 ELYSAT-TWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 367 >gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] Length = 402 Score = 189 bits (481), Expect = 3e-48 Identities = 129/364 (35%), Positives = 184/364 (50%), Gaps = 58/364 (15%) Query: 76 YGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAV 134 +G VEKVV+ + L+ + L+ I GN LV+++VC+ ++LR+ +NY IVSLA ADL V+V V Sbjct: 14 FGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLV 73 Query: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI-TRPLTYPVR 193 MPF ++ +L+ WI+G FC V ++DV+ TASI LC IS+DRY I +PL Y + Sbjct: 74 MPFGAI-ELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132 Query: 194 QNGKCMAKMILSVWLLSASIT-LPPLFGW----------------------------AQN 224 +A M+ W++ I+ LP + GW QN Sbjct: 133 MTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQN 192 Query: 225 VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPD 284 N C+ + Y I + VAFYIP +M+ YY+IY A++ A H+ R Sbjct: 193 SN-STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHA--HQIQMLQRAGAS 249 Query: 285 SVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFF 344 S SR ++ + + E KAA TL II+G F +CW PFF Sbjct: 250 SE-------------------SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFF 290 Query: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404 + + PFI T +P V FLWLGY NS +NPF+YAF N+ R + +L C Sbjct: 291 VTNIVDPFIDYT----VPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDE 346 Query: 405 NINR 408 R Sbjct: 347 RYRR 350 >gi|4503383 dopamine receptor D1 [Homo sapiens] Length = 446 Score = 187 bits (474), Expect = 2e-47 Identities = 124/343 (36%), Positives = 180/343 (52%), Gaps = 40/343 (11%) Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQP-SNYLIVSLALADLSVAVAVMPFVS 139 +++ L+L+ L T+ GN LV +V + LR +N+ ++SLA++DL VAV VMP+ + Sbjct: 23 RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKA 82 Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199 V + I G W FG F CN+++A D+MC TASI+ LCVIS+DRY I+ P Y + K Sbjct: 83 VAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140 Query: 200 AKMILSVWLLSASIT-LPPLFGW----------------AQNVNDDKVCLISQDFGYTIY 242 +I W LS I+ +P W A+ +++ C S Y I Sbjct: 141 FILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDN---CDSSLSRTYAIS 197 Query: 243 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALN-GIVKLQKEVEE 301 S+ ++FYIP+++M+ Y +IY+ A+K + +E +V A N + E Sbjct: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRR-----IAALERAAVHAKNCQTTTGNGKPVE 252 Query: 302 CANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICG---TSC 358 C+ K FKRE K TL +I+G F CWLPFF+L+ PF CG T Sbjct: 253 CSQPESSFKMS------FKRETKVLKTLSVIMGVFVCCWLPFFILNCILPF-CGSGETQP 305 Query: 359 SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401 CI F+W G+ANS +NP IYA FN D R + +LL C Sbjct: 306 FCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGC 347 >gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] Length = 400 Score = 184 bits (466), Expect = 2e-46 Identities = 129/367 (35%), Positives = 181/367 (49%), Gaps = 61/367 (16%) Query: 91 ITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150 + L + GN LV ++V + L+ +NYL+VSLA+ADL VA VMP+V ++ GG W F Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98 Query: 151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---PVRQNGKCMAKMILSVW 207 C+VF+ +DVM CTASI+ LC ISIDRY + P+ Y + + + +A MI +VW Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158 Query: 208 LLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAAR 267 +L+ +++ P LFG+ D VC IS + IYS+ V+FY+P V + +Y +IY + Sbjct: 159 VLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGVTVLVYARIYVVLK 216 Query: 268 KSAAKHKF-----------PGFPR--VEPDSV-------------IALNG---------- 291 + K PGFP+ + PD AL G Sbjct: 217 QRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGEL 276 Query: 292 --------------IVKLQKEVEECAN--LSRLLK-HERKNISIFKREQKAATTLGIIVG 334 KL EV + +N LS LK + + RE+KA + I++G Sbjct: 277 KREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLG 336 Query: 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394 AF VCWLPFFL C T C P T WLGY NS +NP IY FN + R Sbjct: 337 AFIVCWLPFFLTHVLNTH-CQT-CHVSPELYSAT-TWLGYVNSALNPVIYTTFNIEFRKA 393 Query: 395 YRSLLQC 401 + +L C Sbjct: 394 FLKILSC 400 >gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] Length = 397 Score = 184 bits (466), Expect = 2e-46 Identities = 110/334 (32%), Positives = 167/334 (50%), Gaps = 47/334 (14%) Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140 K+ I +L ++ L+T+AGN +V ++V ++LR +N IVSLA+ DL + + V+PF ++ Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77 Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200 L KW FG FCN++ ++DVM CTASI+ L +IS+DRY + PL YPV +A Sbjct: 78 YQL-SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136 Query: 201 KMILSVWLLSASITLPPL-FGWAQNVNDDK------VCLISQDFGYTIYSTAVAFYIPMS 253 ++ +W++S +++ + GW K C + + Y + V FY+P+ Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLL 196 Query: 254 VMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHER 313 +M YY+I+K AR A + + H Sbjct: 197 IMCITYYRIFKVARDQAKR------------------------------------INHIS 220 Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373 + RE KA TL ++GAF +CW P+F TA + I +E LWLG Sbjct: 221 SWKAATIREHKATVTLAAVMGAFIICWFPYF---TAFVYRGLRGDDAINEVLEAIVLWLG 277 Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNIN 407 YANS +NP +YA NRD RT Y+ L C+ N N Sbjct: 278 YANSALNPILYAALNRDFRTGYQQLFCCRLANRN 311 >gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] Length = 359 Score = 184 bits (466), Expect = 2e-46 Identities = 110/334 (32%), Positives = 167/334 (50%), Gaps = 47/334 (14%) Query: 81 KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140 K+ I +L ++ L+T+AGN +V ++V ++LR +N IVSLA+ DL + + V+PF ++ Sbjct: 18 KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77 Query: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMA 200 L KW FG FCN++ ++DVM CTASI+ L +IS+DRY + PL YPV +A Sbjct: 78 YQL-SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVA 136 Query: 201 KMILSVWLLSASITLPPL-FGWAQNVNDDK------VCLISQDFGYTIYSTAVAFYIPMS 253 ++ +W++S +++ + GW K C + + Y + V FY+P+ Sbjct: 137 ISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLL 196 Query: 254 VMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHER 313 +M YY+I+K AR A + + H Sbjct: 197 IMCITYYRIFKVARDQAKR------------------------------------INHIS 220 Query: 314 KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLG 373 + RE KA TL ++GAF +CW P+F TA + I +E LWLG Sbjct: 221 SWKAATIREHKATVTLAAVMGAFIICWFPYF---TAFVYRGLRGDDAINEVLEAIVLWLG 277 Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNIN 407 YANS +NP +YA NRD RT Y+ L C+ N N Sbjct: 278 YANSALNPILYAALNRDFRTGYQQLFCCRLANRN 311 >gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] Length = 408 Score = 177 bits (449), Expect = 2e-44 Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 21/333 (6%) Query: 80 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVS 139 E + G++L L L T+ GN LV++++ + +L+ +N + SLA ADL + + V+P + Sbjct: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVP-PA 94 Query: 140 VTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199 T + G W G C ++ ++DV+C TASI TLC +++DRYL +T PL Y +C Sbjct: 95 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA 154 Query: 200 AKMILSVWLLSASITLPPLFGWAQNVNDD----------KVCLISQDFGYTIYSTAVAFY 249 ++ VW++SA+++ P+ V D + C + + Y + S++V+FY Sbjct: 155 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214 Query: 250 IPMSVMLFMYYQIYKAARKS--AAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSR 307 +P+ VMLF+Y +++ A + + + FP P+ V CA Sbjct: 215 LPLLVMLFVYARVFVVATRQLRLLRGELGRFP---PEESPPAPSRSLAPAPVGTCAPPEG 271 Query: 308 LLKHERKNISIFK-REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVE 366 + R+ + RE +A TLG+I+G FT+CWLPFFL + R S +P Sbjct: 272 VPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL---GGPSLVPGPAF 328 Query: 367 RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399 WLGYANS NP IY + D R+ +R LL Sbjct: 329 LALNWLGYANSAFNPLIYC-RSPDFRSAFRRLL 360 >gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sapiens] Length = 471 Score = 177 bits (448), Expect = 2e-44 Identities = 108/337 (32%), Positives = 181/337 (53%), Gaps = 23/337 (6%) Query: 87 ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146 + ++ +LTIAGN LV+++V KKL+ +NY ++SLA+AD+ + VMP +T L G Sbjct: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139 Query: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILS 205 +W C V+I +DV+ TASIM LC IS+DRY+ I P+ + R N + A + I++ Sbjct: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-RFNSRTKAFLKIIA 198 Query: 206 VWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI 262 VW +S I++P P+FG + V + CL++ D + + + V+F+IP+++M+ Y+ Sbjct: 199 VWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSFFIPLTIMVITYFLT 257 Query: 263 YKAARKSA--------AKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERK 314 K+ +K A + K F + S+ + +K + + R+ Sbjct: 258 IKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSS-------EKLFQRSIHREPGSYTGRR 310 Query: 315 NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-VERTFLWLG 373 + EQKA LGI+ F V W PFF ++ IC SC+ + + F+W+G Sbjct: 311 TMQSISNEQKACKVLGIVFFLFVVMWCPFF-ITNIMAVICKESCNEDVIGALLNVFVWIG 369 Query: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKL 410 Y +S +NP +Y FN+ R+ + +QCQY+ + L Sbjct: 370 YLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPL 406 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.326 0.140 0.441 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,184,990 Number of Sequences: 37866 Number of extensions: 697430 Number of successful extensions: 4420 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 518 Number of HSP's successfully gapped in prelim test: 215 Number of HSP's that attempted gapping in prelim test: 2486 Number of HSP's gapped (non-prelim): 1368 length of query: 432 length of database: 18,247,518 effective HSP length: 105 effective length of query: 327 effective length of database: 14,271,588 effective search space: 4666809276 effective search space used: 4666809276 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.