Guide to the Human Genome
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Name: PAH Sequence: fasta or formatted (452aa) NCBI GI: 4557819
Description:

phenylalanine hydroxylase

Referenced in:

Amino Acid Catabolism
Amino Acid Biosynthesis and Selected Derivatives
Major Disease Loci

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             6.2         28           2
 C cysteine            2.0          9           1
 D aspartate           5.3         24           1
 E glutamate           8.0         36           3
 F phenylalanine       6.0         27           2
 G glycine             5.5         25           2
 H histidine           2.9         13           1
 I isoleucine          6.2         28           2
 K lysine              6.6         30           3
 L leucine            11.1         50           2
 M methionine          0.7          3           1
 N asparagine          3.5         16           1
 P proline             5.1         23           1
 Q glutamine           4.4         20           2
 R arginine            5.3         24           2
 S serine              6.2         28           2
 T threonine           5.3         24           1
 V valine              4.2         19           1
 W tryptophan          0.7          3           1
 Y tyrosine            4.9         22           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   phenylalanine hydroxylase 
TPH2                  0.533   tryptophan hydroxylase 2 
TPH1                  0.521   tryptophan hydroxylase 1 
TH                    0.476   tyrosine hydroxylase isoform c 
TH                    0.476   tyrosine hydroxylase isoform a 
TH                    0.476   tyrosine hydroxylase isoform b 
LOC643166             0.008   PREDICTED: similar to hCG1744891 
F8                    0.008   coagulation factor VIII isoform a precursor 
KIF5B                 0.008   kinesin family member 5B 
DBR1                  0.007   debranching enzyme homolog 1 
PAX7                  0.006   paired box 7 isoform 2 
RNF17                 0.006   ring finger protein 17 
CHL1                  0.004   cell adhesion molecule with homology to L1CAM precur...
KLHL23                0.004   kelch-like 23 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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