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Search of human proteins with 4557695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral
oncogene homolog isoform 1 precursor [Homo sapiens]
(976 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 1995 0.0
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 1980 0.0
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 666 0.0
gi|5453870 platelet-derived growth factor receptor alpha precurs... 534 e-151
gi|4505683 platelet-derived growth factor receptor beta precurso... 503 e-142
gi|169218115 PREDICTED: similar to KIT protein [Homo sapiens] 482 e-136
gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens] 454 e-127
gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline... 402 e-111
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 372 e-103
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 346 5e-95
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 342 1e-93
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 342 1e-93
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 289 1e-77
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 289 1e-77
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 289 1e-77
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 289 1e-77
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 289 1e-77
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 289 1e-77
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 287 4e-77
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 287 4e-77
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 287 4e-77
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 287 4e-77
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 287 4e-77
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 285 1e-76
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 268 2e-71
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 268 2e-71
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 268 2e-71
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 268 2e-71
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 265 1e-70
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 265 1e-70
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 1995 bits (5168), Expect = 0.0
Identities = 976/976 (100%), Positives = 976/976 (100%)
Query: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
Sbjct: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
Query: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
Sbjct: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
Query: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
Sbjct: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
Query: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
Sbjct: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
Query: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
Sbjct: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
Query: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
Sbjct: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
Query: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
Sbjct: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
Query: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
Sbjct: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
Query: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV 540
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
Sbjct: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV 540
Query: 541 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 600
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
Sbjct: 541 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 600
Query: 601 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 660
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
Sbjct: 601 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 660
Query: 661 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 720
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
Sbjct: 661 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 720
Query: 721 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 780
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
Sbjct: 721 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 780
Query: 781 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 840
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
Sbjct: 781 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 840
Query: 841 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 900
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
Sbjct: 841 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 900
Query: 901 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 960
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
Sbjct: 901 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 960
Query: 961 GSTASSSQPLLVHDDV 976
GSTASSSQPLLVHDDV
Sbjct: 961 GSTASSSQPLLVHDDV 976
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 1980 bits (5130), Expect = 0.0
Identities = 972/976 (99%), Positives = 972/976 (99%), Gaps = 4/976 (0%)
Query: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
Sbjct: 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD 60
Query: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
Sbjct: 61 PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV 120
Query: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
Sbjct: 121 DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH 180
Query: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
Sbjct: 181 RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS 240
Query: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
Sbjct: 241 SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN 300
Query: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
Sbjct: 301 VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE 360
Query: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
Sbjct: 361 DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
Query: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
Sbjct: 421 LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS 480
Query: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV 540
SAFKHNGTVECKAYNDVGKTSAYFNFAF KEQIHPHTLFTPLLIGFVIVAGMMCIIV
Sbjct: 481 SAFKHNGTVECKAYNDVGKTSAYFNFAF----KEQIHPHTLFTPLLIGFVIVAGMMCIIV 536
Query: 541 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 600
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
Sbjct: 537 MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF 596
Query: 601 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 660
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
Sbjct: 597 GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC 656
Query: 661 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 720
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
Sbjct: 657 TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE 716
Query: 721 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 780
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
Sbjct: 717 YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM 776
Query: 781 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 840
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
Sbjct: 777 AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES 836
Query: 841 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 900
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
Sbjct: 837 IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY 896
Query: 901 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 960
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
Sbjct: 897 DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV 956
Query: 961 GSTASSSQPLLVHDDV 976
GSTASSSQPLLVHDDV
Sbjct: 957 GSTASSSQPLLVHDDV 972
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 666 bits (1718), Expect = 0.0
Identities = 401/960 (41%), Positives = 552/960 (57%), Gaps = 64/960 (6%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
+LLLL V T + EPS P +L+V+ G + L C G V+W
Sbjct: 5 VLLLLLVATAWHGQGIPVIEPSVP-------ELVVKPGATVTLRCVGNGSVEWDGPPSPH 57
Query: 74 T---NENKQNEWITEKAEATNTGKYTCTNKH---GLSNSIYVFVRDPAKLF-LVDRSLYG 126
++ + T A NTG Y CT G S +I+++V+DPA+ + ++ + +
Sbjct: 58 WTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVV 117
Query: 127 KEDNDTLVRCPLTDPEV-TNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLH 185
ED D L+ C LTDP + SL +G+PL + + P G I K +
Sbjct: 118 FEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQ-DYQ 176
Query: 186 CSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIK--DVSSSVY 243
CS G+ V+S LKV+ P +++ A + GE + C+ DV+ V+
Sbjct: 177 CSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVF 236
Query: 244 STWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTT 303
+++ TKL S H + Y++ TL + +G + C A+N G + +
Sbjct: 237 L----QHNNTKLAIPQQSDFHNN-RYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSM 291
Query: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363
VV+ ++N+ N V GE ++L V EA+P + W Y+ F+D + P
Sbjct: 292 FFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLG-PFSDHQPE-P 349
Query: 364 KSEN---ESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR 420
K N + R+ L L RLK +E G Y+FL N A+ F + + PE+
Sbjct: 350 KLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWT 409
Query: 421 LVNGM--LQCVAAGFPEPTIDWYFCPGTEQRCS-ASVLPV--DVQTLNSSGPPFGKLVVQ 475
+NG L C A+G+P+P + W C G RC A VL V D S PF K+ VQ
Sbjct: 410 FINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQ 469
Query: 476 SSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHP--HTLFTPLLIGFVIVA 533
S + +HN T EC+A+N VG S F G + HP LFTP+++ + +
Sbjct: 470 SLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHT---HPPDEFLFTPVVVACMSIM 526
Query: 534 GMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGK 593
++ +++++L YKY QKP Y+V+WK++E GN+Y +IDPTQLPY+ KWEFPRN L FGK
Sbjct: 527 ALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGK 586
Query: 594 TLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNI 653
TLGAGAFGKVVEATA+GL K DA + VAVKMLK +AH E+EALMSELK++S+LG H NI
Sbjct: 587 TLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENI 646
Query: 654 VNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKNLLHSK 710
VNLLGACT GGP LVITEYCCYGDLLNFLRRK ++ + S +D YKN+ K
Sbjct: 647 VNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEK 706
Query: 711 ESSCSDS------TNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL 764
+ DS + Y++M+P V T ++ S+ E+D+ ++D L
Sbjct: 707 KYVRRDSGFSSQGVDTYVEMRP-----VSTSSND-------SFSEQDLD----KEDGRPL 750
Query: 765 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 824
+L DLL FS QVA+GMAFLASKNCIHRD+AARN+LLT+G + KI DFGLARDI NDSNY+
Sbjct: 751 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 810
Query: 825 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 884
VKGNARLPVKWMAPESIF+CVYT +SDVWSYGI LWE+FSLG +PYPG+ V+SKFYK++K
Sbjct: 811 VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 870
Query: 885 EGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES-TNHIYSNLANCS 943
+G++M P AP +Y IM+ CW +P RPTF+QI +++Q E Y+NL + S
Sbjct: 871 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSS 930
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 534 bits (1375), Expect = e-151
Identities = 353/969 (36%), Positives = 505/969 (52%), Gaps = 93/969 (9%)
Query: 35 SPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETN--------ENKQNEWIT-- 84
S PSI P +++ +V++ L C V W + + +E + EN ++T
Sbjct: 26 SLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVL 85
Query: 85 --EKAEATNTGKYTCTNKHGLSNS-------IYVFVRDPAKLF----LVDRSLYGKEDND 131
A A +TG YTC H + IY++V DP F + D + ++D+
Sbjct: 86 EVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDS 145
Query: 132 TLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQE 191
++ C TDPE T +L +G +P D + G Y C +
Sbjct: 146 AIIPCRTTDPE-TPVTLHNSEGV-VPASY----DSRQGFNGTFTVGPYI-----CEATVK 194
Query: 192 GKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWK---- 247
GK + F + A + + + + + GE VTC + + + V W
Sbjct: 195 GKKFQTIPFNVYALKATSELDL-EMEALKTVYKSGETIVVTCAVFN-NEVVDLQWTYPGE 252
Query: 248 -RENSQTKLQE-KYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVT--T 303
+ T L+E K S + TLT+ A V DSG + C A
Sbjct: 253 VKGKGITMLEEIKVPS-------IKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKV 305
Query: 304 TLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYP 363
T+ V +KGFI I P + VN E +VE A+P P W+ N T + +
Sbjct: 306 TISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRIS-WLKNNLTLIENLTEIT 364
Query: 364 KS-ENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLV 422
E IRY S+L L R K + G YT + N D + F + IL
Sbjct: 365 TDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDH 424
Query: 423 NGM-----LQCVAAGFPEPTIDWYFCPGTEQ---RCSASVLPVDVQTLNSSGPPFGKLVV 474
+G ++C A G P P I+W C ++ S ++L +V + + + V
Sbjct: 425 HGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTV 484
Query: 475 QSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAG 534
+ + + + V C A N +G + E T+ +L+ VIV
Sbjct: 485 EGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSEL----TVAAAVLVLLVIV-- 538
Query: 535 MMCIIVMILTYKYLQKPMYEVQWKVVEEIN--GNNYVYIDPTQLPYDHKWEFPRNRLSFG 592
++ +IV+++ +K QKP YE++W+V+E I+ G+ Y+Y+DP QLPYD +WEFPR+ L G
Sbjct: 539 IISLIVLVVIWK--QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLG 596
Query: 593 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMN 652
+ LG+GAFGKVVE TAYGL +S M VAVKMLKP+A +E++ALMSELK++++LG H+N
Sbjct: 597 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLN 656
Query: 653 IVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKES 712
IVNLLGACT GP +ITEYC YGDL+N+L + RDSF+ E + L + ES
Sbjct: 657 IVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADES 716
Query: 713 SCS------DSTNEYMDMKPG--VSYV-------VPTKADKRRSV--RIGSY-----IER 750
+ S ++ +YMDMK YV V +D +RS+ R SY ++
Sbjct: 717 TRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDS 776
Query: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
+V + +D+ L L DLLSF+YQVA+GM FLASKNC+HRDLAARN+LL G+I KICD
Sbjct: 777 EVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICD 836
Query: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
FGLARDI +DSNYV KG+ LPVKWMAPESIF+ +YT SDVWSYGI LWE+FSLG +PY
Sbjct: 837 FGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPY 896
Query: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
PGM VDS FY IK G+RM P+HA +E+Y+IM CW+++P KRP+F + +++E +
Sbjct: 897 PGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPG 956
Query: 931 STNHIYSNL 939
Y +
Sbjct: 957 QYKKSYEKI 965
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 503 bits (1295), Expect = e-142
Identities = 353/997 (35%), Positives = 514/997 (51%), Gaps = 109/997 (10%)
Query: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
L LLLLL +P +S G P PG +L++ V L C+ V W
Sbjct: 18 LLSLLLLL-------EPQISQGLVVTP---PGP-ELVLNVSSTFVLTCSGSAPVVWERMS 66
Query: 71 LDETNE--NKQNEWITEKAEATN-----TGKYTCTNK--HGLSNS----IYVFVRDPAKL 117
+ E Q+ + TN TG+Y CT+ GL +Y+FV DP
Sbjct: 67 QEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVG 126
Query: 118 FLVDRS----LYGKEDNDTLVRCPLTDPE--VTNYSLKGCQGKPLPKDLRFIPDPKAGIM 171
FL + + ++ E + + C +TDP+ VT + KG P+P D + G
Sbjct: 127 FLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYD------HQRGFS 180
Query: 172 IKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTV 231
R+Y +C D+E S + L+V VSV+ ++R+GE T+
Sbjct: 181 GIFEDRSY--ICKTTIGDREVDSDAYYVYRLQVSSIN-----VSVNAVQTVVRQGENITL 233
Query: 232 TCTIKDVSSSVYS---TWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVF 288
C + + + V + T+ R+ S +L E + D Y ++ L I SA + DSG +
Sbjct: 234 MCIV--IGNEVVNFEWTYPRKESG-RLVEPVTDFLL-DMPYHIRSILHIPSAELEDSGTY 289
Query: 289 MCYANNTFGSAN--VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQ 346
C + + VV+ G++ + + T F + L V +EA+P P
Sbjct: 290 TCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPT-V 348
Query: 347 QWIYMNRTFTDK--WEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIA 404
W NRT D E + N S RYVSEL L R+K E G YT + D ++
Sbjct: 349 LWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLS 408
Query: 405 FNVYVNTKPEIL----TYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPV--- 457
F + +N +L ++ ++C G P+P I W C + RC + P
Sbjct: 409 FQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-RCPRELPPTLLG 467
Query: 458 -------DVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKG 510
++T + + V S++ +V C N VG+ +
Sbjct: 468 NSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDT--------- 518
Query: 511 NNKEQIHPHTL-FTPLLIGFVIVAGMMCII-VMILTYKYLQKPMYEVQWKVVEEIN--GN 566
+ + PH+L F ++I ++ ++ II ++IL + +KP YE++WKV+E ++ G+
Sbjct: 519 -QEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGH 577
Query: 567 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 626
Y+Y+DP QLPYD WE PR++L G+TLG+GAFG+VVEATA+GL S A M VAVKMLK
Sbjct: 578 EYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK 637
Query: 627 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 686
+A +E++ALMSELK++S+LG H+N+VNLLGACT GGP +ITEYC YGDL+++L R +
Sbjct: 638 STARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNK 697
Query: 687 DSFIC--SKQEDHAEAALYKNLLH------SKESSCSDSTNEYMDMKP--GVSYV--VPT 734
+F+ S + A LY N L S S +S YMDM V YV +
Sbjct: 698 HTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDM 757
Query: 735 KAD-KRRSVRIGSYI-----------ERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAF 782
K D K + +Y+ ER ++ + + L DL+ FSYQVA GM F
Sbjct: 758 KGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPV-LSYMDLVGFSYQVANGMEF 816
Query: 783 LASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIF 842
LASKNC+HRDLAARN+L+ G++ KICDFGLARDI DSNY+ KG+ LP+KWMAPESIF
Sbjct: 817 LASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIF 876
Query: 843 NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 902
N +YT SDVWS+GI LWE+F+LG +PYP +P++ +FY IK G+RM P HA E+Y+I
Sbjct: 877 NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEI 936
Query: 903 MKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNL 939
M+ CW+ RP F Q+V L+E+ + E Y +
Sbjct: 937 MQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQV 973
>gi|169218115 PREDICTED: similar to KIT protein [Homo sapiens]
Length = 245
Score = 482 bits (1240), Expect = e-136
Identities = 232/243 (95%), Positives = 237/243 (97%)
Query: 318 MINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSEL 377
MINTTVFVNDGENVDLIVEYEAFPKPEHQQWI +NRTFTDKWEDYPKSENESNIRYVSEL
Sbjct: 1 MINTTVFVNDGENVDLIVEYEAFPKPEHQQWISLNRTFTDKWEDYPKSENESNIRYVSEL 60
Query: 378 HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPT 437
HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVA GFPEPT
Sbjct: 61 HLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAPGFPEPT 120
Query: 438 IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV 497
IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV
Sbjct: 121 IDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDV 180
Query: 498 GKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQW 557
GKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPM +
Sbjct: 181 GKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMMKYSG 240
Query: 558 KVV 560
+++
Sbjct: 241 RLL 243
>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
Length = 993
Score = 454 bits (1167), Expect = e-127
Identities = 274/730 (37%), Positives = 397/730 (54%), Gaps = 46/730 (6%)
Query: 223 LREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLT----IS 278
L+ GE + C V+ TW+ EN K E+ N + ++ R +S
Sbjct: 262 LKVGEPLWIRCKAVHVNHGFGLTWELEN---KALEEGNYFEMSTYSTNRTMIRILFAFVS 318
Query: 279 SARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYE 338
S ND+G + C ++ + + T +V+KGFIN + ++ E V ++
Sbjct: 319 SVARNDTGYYTCSSSKHPSQSALVT---IVEKGFINATNS-SEDYEIDQYEEFCFSVRFK 374
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSD 398
A+P+ W + ++F + + + S ++ + H + G Y F N D
Sbjct: 375 AYPQIRCT-WTFSRKSFPCEQKGLDNGYSIS--KFCNHKH-------QPGEYIFHAENDD 424
Query: 399 VNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVD 458
F + + KP++L C + G+P P+ W C C+ +
Sbjct: 425 AQFTKMFTLNIRRKPQVLA--EASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE-G 481
Query: 459 VQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHP 518
V ++ FG+ V S+++ S V+C AYN +G + G
Sbjct: 482 VWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFP----- 536
Query: 519 HTLFTPLLIGFVIVAGMMCIIVMILT----YKYLQKPMYEVQWKVVEEING--NNYVYID 572
F I F G+ + +++LT +KY ++ YE Q ++V+ N Y Y+D
Sbjct: 537 ---FIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVD 593
Query: 573 PTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLT 632
+ YD KWEFPR L FGK LG+GAFGKV+ ATAYG+ K+ ++ VAVKMLK A +
Sbjct: 594 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 653
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
EREALMSELK+++ LG+H NIVNLLGACT+ GP +I EYCCYGDLLN+LR KR+ F +
Sbjct: 654 EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRT 713
Query: 693 KQEDHAEA--ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIER 750
E E + Y SS S + + P + + S IE
Sbjct: 714 WTEIFKEHNFSFYPTFQSHPNSSMPGSRE--VQIHPDSDQISGLHGNSFHSE---DEIEY 768
Query: 751 DVTPAIMEDDEL-ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKIC 809
+ + E+++L L EDLL F+YQVAKGM FL K+C+HRDLAARN+L+THG++ KIC
Sbjct: 769 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIC 828
Query: 810 DFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP 869
DFGLARDI +DSNYVV+GNARLPVKWMAPES+F +YT +SDVWSYGI LWE+FSLG +P
Sbjct: 829 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 888
Query: 870 YPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQIS 929
YPG+PVD+ FYK+I+ GF+M P +A E+Y IM++CW D KRP+F + + Q++
Sbjct: 889 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLA 948
Query: 930 ESTNHIYSNL 939
++ +Y N+
Sbjct: 949 DAEEAMYQNV 958
Score = 35.4 bits (80), Expect = 0.26
Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 5/84 (5%)
Query: 372 RYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYV-NTKPEILT--YDRLVNGM--L 426
R V + + ++ T+ G Y + + N I F V + NT L Y R + L
Sbjct: 123 RGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDAL 182
Query: 427 QCVAAGFPEPTIDWYFCPGTEQRC 450
C++ PEP ++W C + C
Sbjct: 183 VCISESVPEPIVEWVLCDSQGESC 206
>gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline
sarcoma viral oncogene homolog [Homo sapiens]
Length = 208
Score = 402 bits (1032), Expect = e-111
Identities = 197/198 (99%), Positives = 197/198 (99%)
Query: 113 DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI 172
DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI
Sbjct: 5 DPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMI 64
Query: 173 KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT 232
KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT
Sbjct: 65 KSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVT 124
Query: 233 CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA 292
CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA
Sbjct: 125 CTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYA 184
Query: 293 NNTFGSANVTTTLEVVDK 310
NNTFGSANVTTTLEVV K
Sbjct: 185 NNTFGSANVTTTLEVVGK 202
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 372 bits (956), Expect = e-103
Identities = 246/680 (36%), Positives = 367/680 (53%), Gaps = 77/680 (11%)
Query: 273 ATLTISSARVNDSGVFMCYANNTFGSA--NVTTTLEVVDKGFINIFPMINTTVFVNDGEN 330
+TL ++ +R+ SG+++C A+N G+ N++ + V GF +N +GE+
Sbjct: 520 STLVVADSRI--SGIYICIASNKVGTVGRNISFYITDVPNGF-----HVNLEKMPTEGED 572
Query: 331 VDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNI--RYVSELHLTRLKGT--E 386
+ L F + WI + RT ++ Y S+ + I + L+LT + + +
Sbjct: 573 LKLSCTVNKFLYRD-VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQD 630
Query: 387 GGTYTFLVSNSDVNAAIAFNVYVNTKPEILTY------DRLV----NGMLQCVAAGFPEP 436
GTY N I + + + Y D V + L C A G PEP
Sbjct: 631 SGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEP 690
Query: 437 TIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYND 496
I W+ Q+ +L GP L ++ + G CKA N
Sbjct: 691 QITWFKNNHKIQQEPGIIL----------GPGSSTLFIERVTEED----EGVYHCKATNQ 736
Query: 497 VGKTSAYFNFAFKG-NNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEV 555
G + +G ++K + TL VA + +++ L + +++ E+
Sbjct: 737 KGSVESSAYLTVQGTSDKSNLELITLTC------TCVAATLFWLLLTLFIRKMKRSSSEI 790
Query: 556 QWKVVEEINGNNYVYIDPT--QLPYD-HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLI 612
+ + I + V +D +LPYD KWEF R RL GK+LG GAFGKVV+A+A+G+
Sbjct: 791 KTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIK 850
Query: 613 KSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITE 671
KS TVAVKMLK A +E +ALM+ELK+L+++G+H+N+VNLLGACT GGP +VI E
Sbjct: 851 KSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVE 910
Query: 672 YCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYV 731
YC YG+L N+L+ KRD F +K +AAL+ K M+PG+
Sbjct: 911 YCKYGNLSNYLKSKRDLFFLNK-----DAALHMEPKKEK-------------MEPGLEQG 952
Query: 732 VPTKADKRRSVR--IGSYIERDVTPAIMEDDELA-------LDLEDLLSFSYQVAKGMAF 782
+ D S S + D + + +E++E + + +EDL+S+S+QVA+GM F
Sbjct: 953 KKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEF 1012
Query: 783 LASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIF 842
L+S+ CIHRDLAARNILL+ + KICDFGLARDI + +YV KG+ RLP+KWMAPESIF
Sbjct: 1013 LSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF 1072
Query: 843 NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 902
+ +Y+ +SDVWSYG+ LWE+FSLG SPYPG+ +D F ++EG RM +PE++ E+Y I
Sbjct: 1073 DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQI 1132
Query: 903 MKTCWDADPLKRPTFKQIVQ 922
M CW DP +RP F ++V+
Sbjct: 1133 MLDCWHRDPKERPRFAELVE 1152
Score = 93.2 bits (230), Expect = 1e-18
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
Query: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
Query: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
Query: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
Query: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
Query: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
Query: 435 EPTIDWYFCP----GTEQRC 450
+PTI W++ P +E RC
Sbjct: 461 QPTIKWFWHPCNHNHSEARC 480
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 346 bits (888), Expect = 5e-95
Identities = 208/524 (39%), Positives = 294/524 (56%), Gaps = 78/524 (14%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+ C A+G P P I W+ T S VL + L +I +
Sbjct: 686 VSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNL--------------TIRRVRKED 731
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
G C+A + +G F +G ++ L +L+G ++A ++++I+
Sbjct: 732 EGLYTCQACSVLGCAKVEAFFIIEGAQEKT----NLEIIILVGTAVIAMFFWLLLVIIL- 786
Query: 546 KYLQKPMYEVQWKVVEEINGNNY------VYIDPTQLPYDH----------KWEFPRNRL 589
+ V+ NG + +DP +LP D KWEFPR+RL
Sbjct: 787 ------------RTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRL 834
Query: 590 SFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGN 649
GK LG GAFG+V+EA A+G+ K+ TVAVKMLK A +E ALMSELK+L ++G+
Sbjct: 835 KLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGH 894
Query: 650 HMNIVNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQE--------DHAEA 700
H+N+VNLLGACT GGP +VI E+C +G+L +LR KR+ F+ K + D+ A
Sbjct: 895 HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGA 954
Query: 701 ALY--KNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIME 758
K L S SS S +++ +++ K S +E + P +
Sbjct: 955 IPVDLKRRLDSITSSQSSASSGFVEEKSL------------------SDVEEEEAPEDLY 996
Query: 759 DDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIK 818
D L L E L+ +S+QVAKGM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI
Sbjct: 997 KDFLTL--EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 1054
Query: 819 NDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK 878
D +YV KG+ARLP+KWMAPE+IF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ +D +
Sbjct: 1055 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE 1114
Query: 879 FYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
F + +KEG RM +P++ EMY M CW +P +RPTF ++V+
Sbjct: 1115 FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVE 1158
Score = 66.6 bits (161), Expect = 1e-10
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 63/483 (13%)
Query: 11 LCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEI 70
L + L L V+T ++ + P + K L ++ +++ C + W +
Sbjct: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP- 64
Query: 71 LDETNENKQNEWITE-------------KAEATNTGKYTCTNKH-GLSNSIYVFVRDPAK 116
+ + ++Q +TE K +TG Y C + L++ IYV+V+D
Sbjct: 65 -NNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRS 123
Query: 117 LFLVDRS-----LYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPD------ 165
F+ S +Y E+ + V P ++N ++ C P + RF+PD
Sbjct: 124 PFIASVSDQHGVVYITENKNKTVVIPCLG-SISNLNVSLCARYP---EKRFVPDGNRISW 179
Query: 166 -PKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLR 224
K G I S +Y + + C +S S +I+ V ++ VV L
Sbjct: 180 DSKKGFTIPSYMISYAGM-VFCEAKINDESYQSIMYIVVV-VGYRIYDVVLSPSHGIELS 237
Query: 225 EGEEFTVTCTIK-DVSSSVYSTWKRENSQ---TKLQEKYNSWHHGDFNYERQATLTISSA 280
GE+ + CT + +++ + W+ +S+ KL + G + +TLTI
Sbjct: 238 VGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGV 297
Query: 281 RVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAF 340
+D G++ C A++ + +T + V +K F+ + + V GE V + +Y +
Sbjct: 298 TRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGY 357
Query: 341 PKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSN--SD 398
P PE +W +++ E+ I+ L + + + G YT +++N S
Sbjct: 358 PPPE-IKW----------YKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISK 406
Query: 399 VNAAIAFNVYVNTKPEI---------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGTEQ 448
+ ++ V P+I +Y L C P P I WY+ E+
Sbjct: 407 EKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW--QLEE 464
Query: 449 RCS 451
C+
Sbjct: 465 ECA 467
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
sapiens]
Length = 1363
Score = 342 bits (877), Expect = 1e-93
Identities = 199/510 (39%), Positives = 299/510 (58%), Gaps = 48/510 (9%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+QC+ AG P+I WY ++R VD+ N KL +Q + A
Sbjct: 697 MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
G C N G ++ + A +G+ + ++ +L+G ++A ++++++ +
Sbjct: 744 -GRYLCSVCNAKGCVNSSASVAVEGSEDKG----SMEIVILVGTGVIAVFFWVLLLLI-F 797
Query: 546 KYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTL 595
+++P + + G + +DP ++P + + WEFPR RL G+ L
Sbjct: 798 CNMRRPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVL 851
Query: 596 GAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVN 655
G GAFGKVVEA+A+G+ K + TVAVKMLK A +E ALMSELK+L ++GNH+N+VN
Sbjct: 852 GYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVN 911
Query: 656 LLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSC 714
LLGACT GP +VI E+C YG+L NFLR KRD+F ++ + ++ ++ E +
Sbjct: 912 LLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELAR 968
Query: 715 SDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSY 774
D + + T+ RR+ + ++P L +EDL+ +S+
Sbjct: 969 LDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSF 1019
Query: 775 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK 834
QVA+GM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +YV KG+ARLP+K
Sbjct: 1020 QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK 1079
Query: 835 WMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEH 894
WMAPESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE
Sbjct: 1080 WMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPEL 1139
Query: 895 APAEMYDIMKTCWDADPLKRPTFKQIVQLI 924
A + IM CW DP RP F ++V+++
Sbjct: 1140 ATPAIRRIMLNCWSGDPKARPAFSELVEIL 1169
Score = 79.3 bits (194), Expect = 2e-14
Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
L L L + G VS +PP+++ + ++ GD + + C ++W + E
Sbjct: 7 LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
Query: 74 T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105
+++ ++ + E T+ TG Y C K+ +
Sbjct: 67 APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
Query: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163
S YVFVRD + F+ D L ++D V C ++ P + N +L+ P +
Sbjct: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
Query: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223
D + G+++ S + L L C + LS F++ + + + + + S L
Sbjct: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
Query: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282
GE+ + CT+ + +S V W Q + + + E + LTI +
Sbjct: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
Query: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338
+D G ++C ANN +T + V + FI++ P++ T E V L V+
Sbjct: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397
A+P PE QW Y + S L L + GTYT + NS
Sbjct: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
Query: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446
+ I+ + VN P+I Y R L C A G P P +I W++ P T
Sbjct: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
sapiens]
Length = 1298
Score = 342 bits (877), Expect = 1e-93
Identities = 199/510 (39%), Positives = 299/510 (58%), Gaps = 48/510 (9%)
Query: 426 LQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKH 485
+QC+ AG P+I WY ++R VD+ N KL +Q + A
Sbjct: 697 MQCLVAGAHAPSIVWY----KDERLLEEKSGVDLADSNQ------KLSIQRVREEDA--- 743
Query: 486 NGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTY 545
G C N G ++ + A +G+ + ++ +L+G ++A ++++++ +
Sbjct: 744 -GRYLCSVCNAKGCVNSSASVAVEGSEDKG----SMEIVILVGTGVIAVFFWVLLLLI-F 797
Query: 546 KYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHK----------WEFPRNRLSFGKTL 595
+++P + + G + +DP ++P + + WEFPR RL G+ L
Sbjct: 798 CNMRRPAH------ADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVL 851
Query: 596 GAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVN 655
G GAFGKVVEA+A+G+ K + TVAVKMLK A +E ALMSELK+L ++GNH+N+VN
Sbjct: 852 GYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVN 911
Query: 656 LLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSC 714
LLGACT GP +VI E+C YG+L NFLR KRD+F ++ + ++ ++ E +
Sbjct: 912 LLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMV---ELAR 968
Query: 715 SDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSY 774
D + + T+ RR+ + ++P L +EDL+ +S+
Sbjct: 969 LDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSP---------LTMEDLVCYSF 1019
Query: 775 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK 834
QVA+GM FLAS+ CIHRDLAARNILL+ + KICDFGLARDI D +YV KG+ARLP+K
Sbjct: 1020 QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK 1079
Query: 835 WMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEH 894
WMAPESIF+ VYT +SDVWS+G+ LWE+FSLG+SPYPG+ ++ +F + +++G RM +PE
Sbjct: 1080 WMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPEL 1139
Query: 895 APAEMYDIMKTCWDADPLKRPTFKQIVQLI 924
A + IM CW DP RP F ++V+++
Sbjct: 1140 ATPAIRRIMLNCWSGDPKARPAFSELVEIL 1169
Score = 79.3 bits (194), Expect = 2e-14
Identities = 109/479 (22%), Positives = 186/479 (38%), Gaps = 67/479 (13%)
Query: 14 LLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDE 73
L L L + G VS +PP+++ + ++ GD + + C ++W + E
Sbjct: 7 LCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQE 66
Query: 74 T----NENKQNEWITEKAEATN-----------------TGKYTCTNKH-------GLSN 105
+++ ++ + E T+ TG Y C K+ +
Sbjct: 67 APATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAA 126
Query: 106 SIYVFVRDPAKLFL--VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFI 163
S YVFVRD + F+ D L ++D V C ++ P + N +L+ P +
Sbjct: 127 SSYVFVRDFEQPFINKPDTLLVNRKDA-MWVPCLVSIPGL-NVTLRSQSSVLWPDGQEVV 184
Query: 164 PDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLL 223
D + G+++ S + L L C + LS F++ + + + + + S L
Sbjct: 185 WDDRRGMLV-STPLLHDALYLQCETTWGDQDFLSNPFLVHIT-GNELYDIQLLPRKSLEL 242
Query: 224 REGEEFTVTCTI-KDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARV 282
GE+ + CT+ + +S V W Q + + + E + LTI +
Sbjct: 243 LVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQ 302
Query: 283 NDSGVFMCYANNTFGSANVTTTLEVVDKGFINI----FPMINTTVFVNDGENVDLIVEYE 338
+D G ++C ANN +T + V + FI++ P++ T E V L V+
Sbjct: 303 HDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATA---GDELVKLPVKLA 359
Query: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNS- 397
A+P PE QW Y + S L L + GTYT + NS
Sbjct: 360 AYPPPEF-QW-------------YKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSA 405
Query: 398 -DVNAAIAFNVYVNTKPEI--------LTYDRLVNGMLQCVAAGFPEP-TIDWYFCPGT 446
+ I+ + VN P+I Y R L C A G P P +I W++ P T
Sbjct: 406 AGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWT 464
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 350 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 409
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 410 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 464
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 465 ---------------------------------PGMEY----------SYDINRVPEEQM 481
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 482 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 529
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 530 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 589
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 590 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 648
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 649 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 157
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 217 VTFEDAGEYTCLAGNS 232
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 351 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 410
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 411 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 465
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 466 ---------------------------------PGMEY----------SYDINRVPEEQM 482
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 483 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 530
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 531 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 590
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 591 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 649
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 650 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 685
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 352 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 411
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 412 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 466
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 467 ---------------------------------PGMEY----------SYDINRVPEEQM 483
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 484 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 531
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 532 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 591
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 592 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 650
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 651 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 686
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 100 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 157
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 158 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 216
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 217 VTFEDAGEYTCLAGNS 232
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 355 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 414
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 415 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 469
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 470 ---------------------------------PGMEY----------SYDINRVPEEQM 486
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 487 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 534
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 535 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 594
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 595 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 653
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 654 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 689
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 467 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 526
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 527 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 581
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 582 ---------------------------------PGMEY----------SYDINRVPEEQM 598
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 599 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 646
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 647 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 706
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 707 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 765
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 766 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 801
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 215 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 272
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 273 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 331
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 332 VTFEDAGEYTCLAGNS 347
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 289 bits (739), Expect = 1e-77
Identities = 164/403 (40%), Positives = 229/403 (56%), Gaps = 70/403 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 468 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 527
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 528 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 582
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 583 ---------------------------------PGMEY----------SYDINRVPEEQM 599
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 600 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 647
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 648 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 707
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 708 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 766
Query: 933 NHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDD 975
N Y +L+ +P+ +S S+ SS + D
Sbjct: 767 NEEYLDLS-------QPLEQYSPSYPDTRSSCSSGDDSVFSPD 802
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 287 bits (734), Expect = 4e-77
Identities = 157/363 (43%), Positives = 215/363 (59%), Gaps = 63/363 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 379 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 438
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 439 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 493
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 494 ---------------------------------PGMEY----------SYDINRVPEEQM 510
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 511 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 558
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 559 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 618
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 619 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 677
Query: 933 NHI 935
N I
Sbjct: 678 NEI 680
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 287 bits (734), Expect = 4e-77
Identities = 157/363 (43%), Positives = 215/363 (59%), Gaps = 63/363 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 468 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 527
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 528 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 582
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 583 ---------------------------------PGMEY----------SYDINRVPEEQM 599
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 600 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 647
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 648 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 707
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 708 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 766
Query: 933 NHI 935
N I
Sbjct: 767 NEI 769
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 450 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 509
Query: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
Query: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
R +R PG+ Y T
Sbjct: 570 RARRP--------------------------------------PGLDYSFDT-------- 583
Query: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 584 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 629
Query: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 630 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 689
Query: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 690 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 748
Query: 923 LIEKQISESTNHIYSNLA 940
+++ ++ ++ Y +L+
Sbjct: 749 DLDRVLTVTSTDEYLDLS 766
Score = 30.8 bits (68), Expect = 6.5
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 336 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 395
Query: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 396 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 455
Query: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
R +R PG+ Y T
Sbjct: 456 RARRP--------------------------------------PGLDYSFDT-------- 469
Query: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 470 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 515
Query: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 516 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 575
Query: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 576 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 634
Query: 923 LIEKQISESTNHIYSNLA 940
+++ ++ ++ Y +L+
Sbjct: 635 DLDRVLTVTSTDEYLDLS 652
Score = 30.8 bits (68), Expect = 6.5
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 287 bits (734), Expect = 4e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 448 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 507
Query: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 508 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
Query: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
R +R PG+ Y T
Sbjct: 568 RARRP--------------------------------------PGLDYSFDT-------- 581
Query: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 582 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 627
Query: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 628 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 687
Query: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 688 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 746
Query: 923 LIEKQISESTNHIYSNLA 940
+++ ++ ++ Y +L+
Sbjct: 747 DLDRVLTVTSTDEYLDLS 764
Score = 30.8 bits (68), Expect = 6.5
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 285 bits (730), Expect = 1e-76
Identities = 156/361 (43%), Positives = 214/361 (59%), Gaps = 63/361 (17%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA--AMTVAVKMLKPSAHLT 632
+LP D KWEFPR++L+ GK LG G FG+VV A A G+ K A+TVAVKMLK A
Sbjct: 378 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 437
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI EY G+L +LR +R
Sbjct: 438 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP----- 492
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDV 752
PG+ Y S I E +
Sbjct: 493 ---------------------------------PGMEY----------SYDINRVPEEQM 509
Query: 753 TPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 812
T +DL+S +YQ+A+GM +LAS+ CIHRDLAARN+L+T + KI DFG
Sbjct: 510 T------------FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 557
Query: 813 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 872
LARDI N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ +WE+F+LG SPYPG
Sbjct: 558 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 617
Query: 873 MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST 932
+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++ +T
Sbjct: 618 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 676
Query: 933 N 933
N
Sbjct: 677 N 677
Score = 31.6 bits (70), Expect = 3.8
Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 15/136 (11%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
+L + S +D G + C N +GS N T L+VV++ + N + V G
Sbjct: 126 SLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV--GG 183
Query: 330 NVDLIVEYEAFPKPEHQQWI-YMNRTFTDKWED---YPKSENESNI----RYVSELHLTR 381
+V+ + + + +P H QWI ++ + + D Y K + + + + L++
Sbjct: 184 DVEFVCKVYSDAQP-HIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRN 242
Query: 382 LKGTEGGTYTFLVSNS 397
+ + G YT L NS
Sbjct: 243 VTFEDAGEYTCLAGNS 258
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 373 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 432
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 433 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 470
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
E + + EY+ + PG+ Y
Sbjct: 471 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 497
Query: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 498 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 550
Query: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 551 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 610
Query: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 611 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 669
Query: 931 STNHIYSNLA 940
++N Y +L+
Sbjct: 670 TSNQEYLDLS 679
Score = 37.0 bits (84), Expect = 0.090
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 123 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 180
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 181 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 239
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 240 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 293
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 375 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 434
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 435 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 472
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
E + + EY+ + PG+ Y
Sbjct: 473 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 499
Query: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 500 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 552
Query: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 553 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 612
Query: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 613 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
Query: 931 STNHIYSNLA 940
++N Y +L+
Sbjct: 672 TSNQEYLDLS 681
Score = 37.0 bits (84), Expect = 0.090
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 125 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 182
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 183 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 241
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 242 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 295
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 462 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 521
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 522 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 559
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
E + + EY+ + PG+ Y
Sbjct: 560 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 586
Query: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 587 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
Query: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
Query: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 700 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 758
Query: 931 STNHIYSNLA 940
++N Y +L+
Sbjct: 759 TSNQEYLDLS 768
Score = 37.0 bits (84), Expect = 0.090
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 269
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 270 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 328
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 329 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 382
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 464 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 523
Query: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 524 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 561
Query: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
E + + EY+ + PG+ Y
Sbjct: 562 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 588
Query: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 589 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 641
Query: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 642 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 701
Query: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 702 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 760
Query: 931 STNHIYSNLA 940
++N Y +L+
Sbjct: 761 TSNQEYLDLS 770
Score = 37.0 bits (84), Expect = 0.090
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 214 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 271
Query: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 272 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 384
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 265 bits (678), Expect = 1e-70
Identities = 152/379 (40%), Positives = 214/379 (56%), Gaps = 56/379 (14%)
Query: 567 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 626
N V +D ++ D KWEFPR L GKTLG G FGKVV+ATA+ L TVAVKMLK
Sbjct: 702 NQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK 761
Query: 627 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 686
+A +E L+SE VL + NH +++ L GAC+ GP L+I EY YG L FLR R
Sbjct: 762 ENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
Query: 687 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 746
K G Y +GS
Sbjct: 821 --------------------------------------KVGPGY-------------LGS 829
Query: 747 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 806
R+ + ++ DE AL + DL+SF++Q+++GM +LA +HRDLAARNIL+ GR
Sbjct: 830 GGSRN-SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM 888
Query: 807 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 866
KI DFGL+RD+ + +YV + R+PVKWMA ES+F+ +YT +SDVWS+G+ LWE+ +LG
Sbjct: 889 KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG 948
Query: 867 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 926
+PYPG+P + + + ++K G RM P++ EMY +M CW +P KRP F I + +EK
Sbjct: 949 GNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
Query: 927 QISESTNHIYSNLANCSPN 945
+ + + Y +LA +P+
Sbjct: 1008 MMVKRRD--YLDLAASTPS 1024
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 265 bits (678), Expect = 1e-70
Identities = 152/379 (40%), Positives = 214/379 (56%), Gaps = 56/379 (14%)
Query: 567 NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK 626
N V +D ++ D KWEFPR L GKTLG G FGKVV+ATA+ L TVAVKMLK
Sbjct: 702 NQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK 761
Query: 627 PSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKR 686
+A +E L+SE VL + NH +++ L GAC+ GP L+I EY YG L FLR R
Sbjct: 762 ENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR 820
Query: 687 DSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGS 746
K G Y +GS
Sbjct: 821 --------------------------------------KVGPGY-------------LGS 829
Query: 747 YIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 806
R+ + ++ DE AL + DL+SF++Q+++GM +LA +HRDLAARNIL+ GR
Sbjct: 830 GGSRN-SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM 888
Query: 807 KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLG 866
KI DFGL+RD+ + +YV + R+PVKWMA ES+F+ +YT +SDVWS+G+ LWE+ +LG
Sbjct: 889 KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG 948
Query: 867 SSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK 926
+PYPG+P + + + ++K G RM P++ EMY +M CW +P KRP F I + +EK
Sbjct: 949 GNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
Query: 927 QISESTNHIYSNLANCSPN 945
+ + + Y +LA +P+
Sbjct: 1008 MMVKRRD--YLDLAASTPS 1024
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,395,480
Number of Sequences: 37866
Number of extensions: 1779961
Number of successful extensions: 8437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 573
Number of HSP's successfully gapped in prelim test: 333
Number of HSP's that attempted gapping in prelim test: 4760
Number of HSP's gapped (non-prelim): 2742
length of query: 976
length of database: 18,247,518
effective HSP length: 112
effective length of query: 864
effective length of database: 14,006,526
effective search space: 12101638464
effective search space used: 12101638464
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.