Search of human proteins with 4557567

Search of human proteins with 4557567

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557567 epiregulin preproprotein [Homo sapiens]
         (169 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557567 epiregulin preproprotein [Homo sapiens]                    353   5e-98
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...    56   1e-08
gi|4502461 betacellulin [Homo sapiens]                                 56   1e-08
gi|61806622 epithelial mitogen [Homo sapiens]                          55   3e-08
gi|12383051 transmembrane protein with EGF-like and two follista...    54   6e-08
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                       53   1e-07
gi|29568105 transmembrane protein with EGF-like and two follista...    52   2e-07
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap...    51   5e-07
gi|20070380 neuregulin 4 [Homo sapiens]                                49   2e-06
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s...    49   3e-06
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                       49   3e-06
gi|4502199 amphiregulin preproprotein [Homo sapiens]                   45   2e-05
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]                  45   2e-05
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]       42   3e-04
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...    41   4e-04
gi|66730481 neuregulin 3 [Homo sapiens]                                41   6e-04
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                       41   6e-04
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]                39   0.002
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]            39   0.002
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]             39   0.002
gi|126012573 low density lipoprotein-related protein 2 [Homo sap...    39   0.003
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]                38   0.005
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]               38   0.005
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]                   38   0.005
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                       38   0.005
gi|139394621 chondroitin sulfate proteoglycan 5 (neuroglycan C) ...    37   0.006
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]            37   0.008
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]            37   0.008
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]            37   0.008
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]             37   0.008

>gi|4557567 epiregulin preproprotein [Homo sapiens]
          Length = 169

 Score =  353 bits (905), Expect = 5e-98
 Identities = 169/169 (100%), Positives = 169/169 (100%)

Query: 1   MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV 60
           MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV
Sbjct: 1   MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV 60

Query: 61  AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA 120
           AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA
Sbjct: 61  AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA 120

Query: 121 LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV 169
           LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
Sbjct: 121 LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV 169


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
            sapiens]
          Length = 1207

 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 31/113 (27%), Positives = 60/113 (53%), Gaps = 7/113 (6%)

Query: 52   VQTEDNPRVAQVSITKCSSDMNGYCLH-GQCIYLVDMSQNYCRCEVGYTGVRCEH----F 106
            ++ +D+    + S ++C    +GYCLH G C+Y+  + +  C C VGY G RC++    +
Sbjct: 960  LREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKW 1019

Query: 107  FLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK--SKEPKKEYE 157
            +   H    ++   + V + ++ L+ ++  + +   +YR +K  SK PK  YE
Sbjct: 1020 WELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYE 1072


>gi|4502461 betacellulin [Homo sapiens]
          Length = 178

 Score = 56.2 bits (134), Expect = 1e-08
 Identities = 47/163 (28%), Positives = 72/163 (44%), Gaps = 12/163 (7%)

Query: 12  AGRVPALL-LCLGFHLLQAVLS---TTVIPSC---IPGESSDNCTALVQTEDNPRVAQVS 64
           A  +P LL L LG  +L  V++   +T  P     + G+  +NC A   T  + R    S
Sbjct: 10  ASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAAT--TTQSKRKGHFS 67

Query: 65  ITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVI 124
             +C      YC+ G+C ++V      C C+ GY G RCE   L   +    + + + +I
Sbjct: 68  --RCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQILVICLI 125

Query: 125 LIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELP 167
            +++  I +V      C   R R+ K  KKE E  T G    P
Sbjct: 126 AVMVVFIILVIGVCTCCHPLRKRR-KRKKKEEEMETLGKDITP 167


>gi|61806622 epithelial mitogen [Homo sapiens]
          Length = 133

 Score = 55.1 bits (131), Expect = 3e-08
 Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 11/88 (12%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKE-YVALTV--- 123
           C  D N YC++G C +  ++ +  CRC  GYTG RCEH  LT +   S E Y+A+ +   
Sbjct: 51  CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVG 110

Query: 124 ILIILFLITVVGSTYYFCRWYRNRKSKE 151
           +L+  FL+       ++C + R R  K+
Sbjct: 111 LLLSGFLV------IFYC-YIRKRYEKD 131


>gi|12383051 transmembrane protein with EGF-like and two
           follistatin-like domains 2 [Homo sapiens]
          Length = 374

 Score = 53.9 bits (128), Expect = 6e-08
 Identities = 28/102 (27%), Positives = 44/102 (43%), Gaps = 18/102 (17%)

Query: 42  GESSDNCTALVQTEDN--------------PRVAQVSITKCSSDMNGYCLHGQCIYLVDM 87
           G   DN T   ++ED                  A+     C    NG+C+HG+C + ++M
Sbjct: 225 GRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINM 284

Query: 88  SQNYCRCEVGYTGVRCE----HFFLTVHQPLSKEYVALTVIL 125
            +  CRC+ GYTG  CE         V  P+  +YV +  ++
Sbjct: 285 QEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVI 326


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score = 52.8 bits (125), Expect = 1e-07
 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 6/87 (6%)

Query: 67  KCSSDMNGYCLHGQ-CIYLVDMSQNYCRCEVGYTGVRCEHF----FLTVHQPLSKEYVAL 121
           KC+     YC++G  C Y+  ++Q  C+C VGYTG RC+ F    F    +   K  + +
Sbjct: 344 KCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTI 403

Query: 122 TVILIILFLITVVGSTYYFCRWYRNRK 148
           T I + L ++ +V    Y C+  + RK
Sbjct: 404 TGICVALLVVGIVCVVAY-CKTKKQRK 429


>gi|29568105 transmembrane protein with EGF-like and two
           follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 52.4 bits (124), Expect = 2e-07
 Identities = 18/37 (48%), Positives = 25/37 (67%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCE 104
           C  ++NGYC+HG+C ++    +  CRCE GYTG  CE
Sbjct: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE 311


>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
           sapiens]
          Length = 160

 Score = 50.8 bits (120), Expect = 5e-07
 Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 4/101 (3%)

Query: 35  VIPSCIPGESSDNCTALVQTEDNPRVAQVS-ITKCSSDMNGYCLHGQCIYLVDMSQNYCR 93
           V+ +C   ++ +N T+ +  +     A VS    C      +C HG C +LV   +  C 
Sbjct: 16  VLAAC---QALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACV 72

Query: 94  CEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVV 134
           C  GY G RCEH  L      S++  A+T ++++  +   V
Sbjct: 73  CHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAV 113


>gi|20070380 neuregulin 4 [Homo sapiens]
          Length = 115

 Score = 49.3 bits (116), Expect = 2e-06
 Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 68  CSSDMNGYCLHGQCIYLVD-MSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILI 126
           C      +CL+G   Y++  +   +CRC   YTG RCE  FL      +K  +    + +
Sbjct: 9   CGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVAL 68

Query: 127 ILFLITVVGSTYYFCR 142
            + +  ++G+ Y+ CR
Sbjct: 69  AVLVTLIIGAFYFLCR 84


>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
           sapiens]
          Length = 159

 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 21/67 (31%), Positives = 32/67 (47%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILII 127
           C      +C HG C +LV   +  C C  GY G RCEH  L      S++  A+T ++++
Sbjct: 46  CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVV 105

Query: 128 LFLITVV 134
             +   V
Sbjct: 106 SIVALAV 112


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score = 48.5 bits (114), Expect = 3e-06
 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 14/95 (14%)

Query: 67  KCSSDMNGYCLHGQ-CIYLVDMSQNYCRCEVGYTGVRCEHFFLT------------VHQP 113
           KC+     YC++G  C Y+  ++Q  C+C VGYTG RC+ F +               + 
Sbjct: 344 KCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEEL 403

Query: 114 LSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             K  + +T I + L ++ +V    Y C+  + RK
Sbjct: 404 YQKRVLTITGICVALLVVGIVCVVAY-CKTKKQRK 437


>gi|4502199 amphiregulin preproprotein [Homo sapiens]
          Length = 252

 Score = 45.4 bits (106), Expect = 2e-05
 Identities = 16/67 (23%), Positives = 32/67 (47%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILII 127
           C+++   +C+HG+C Y+  +    C+C+  Y G RC    +  H  +      + +  I 
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205

Query: 128 LFLITVV 134
            F+  V+
Sbjct: 206 AFMSAVI 212


>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
          Length = 252

 Score = 45.4 bits (106), Expect = 2e-05
 Identities = 16/67 (23%), Positives = 32/67 (47%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILII 127
           C+++   +C+HG+C Y+  +    C+C+  Y G RC    +  H  +      + +  I 
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205

Query: 128 LFLITVV 134
            F+  V+
Sbjct: 206 AFMSAVI 212


>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
          Length = 208

 Score = 41.6 bits (96), Expect = 3e-04
 Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 5/73 (6%)

Query: 68  CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPL-----SKEYVALT 122
           C      +C+HG+C Y+ ++    C C  GY G RC    L V   L     +     + 
Sbjct: 108 CLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVA 167

Query: 123 VILIILFLITVVG 135
           V+L  + L+ +VG
Sbjct: 168 VVLSSVCLLVIVG 180


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score = 41.2 bits (95), Expect = 4e-04
 Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 17/121 (14%)

Query: 42   GESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGV 101
            G+ + NCT       + RVA   +T       G+C +G    +       C+C    TG 
Sbjct: 4359 GDVTCNCT-------DGRVAPSCLTCV-----GHCSNGGSCTMNSKMMPECQCPPHMTGP 4406

Query: 102  RCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTS 161
            RCE    +  QP     + L  +L++L L+ V G  +    WY+ R       +++R+T+
Sbjct: 4407 RCEEHVFSQQQPGHIASI-LIPLLLLLLLVLVAGVVF----WYKRRVQGAKGFQHQRMTN 4461

Query: 162  G 162
            G
Sbjct: 4462 G 4462



 Score = 31.2 bits (69), Expect = 0.44
 Identities = 20/67 (29%), Positives = 27/67 (40%), Gaps = 4/67 (5%)

Query: 38   SCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVG 97
            +C  G+  DN T +      P         C    N  C +G   +L    Q  CRC+  
Sbjct: 4170 TCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC----NLQCFNGGSCFLNARRQPKCRCQPR 4225

Query: 98   YTGVRCE 104
            YTG +CE
Sbjct: 4226 YTGDKCE 4232



 Score = 29.6 bits (65), Expect = 1.3
 Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 1/40 (2%)

Query: 67   KCSSDM-NGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEH 105
            KC+  +  GYC +     +   +Q  CRC  G+ G RC++
Sbjct: 4266 KCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQY 4305



 Score = 28.5 bits (62), Expect = 2.9
 Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 21/67 (31%)

Query: 39   CIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLH-GQCIYLVDMSQNYCRCEVG 97
            C+PG   D C                  +CS    GYC + G C    D S+  CRC   
Sbjct: 4294 CLPGFLGDRC---------------QYRQCS----GYCENFGTCQMAADGSRQ-CRCTAY 4333

Query: 98   YTGVRCE 104
            + G RCE
Sbjct: 4334 FEGSRCE 4340


>gi|66730481 neuregulin 3 [Homo sapiens]
          Length = 696

 Score = 40.8 bits (94), Expect = 6e-04
 Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 21/110 (19%)

Query: 68  CSSDMNGYCLH-GQCIYLVDM--SQNYCRCEVGYTGVRCEHFF-------------LTVH 111
           C      YCL+ G+C  +  +  S  +CRC+ GY GVRC+ F              L + 
Sbjct: 290 CRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIE 349

Query: 112 QPLSKEYVALTVILI--ILFLITVVGSTYYFCRWYRNRKSKEPKKEYERV 159
              S+E     V+ I  I+F I +VG    FC  +  +  K+ K+  E++
Sbjct: 350 FMESEEVYQRQVLSISCIIFGIVIVG---MFCAAFYFKSKKQAKQIQEQL 396


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score = 40.8 bits (94), Expect = 6e-04
 Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 12/93 (12%)

Query: 67  KCSSDMNGYCLHGQ-CIYLVDMSQNYCRCEVGYTGVRC-EHFFLTVHQP---------LS 115
           KC+     YC++G  C Y+  ++Q  C+C  G+ G RC E   L ++ P           
Sbjct: 344 KCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQ 403

Query: 116 KEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
           K  + +T I + L ++ +V    Y C+  + RK
Sbjct: 404 KRVLTITGICVALLVVGIVCVVAY-CKTKKQRK 435


>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
          Length = 459

 Score = 38.9 bits (89), Expect = 0.002
 Identities = 23/92 (25%), Positives = 46/92 (50%), Gaps = 9/92 (9%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF----FLTVHQPLSK 116
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++    F    +   K
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQK 238

Query: 117 EYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 RVLTITGICIALLVVGIMCVVAY-CKTKKQRK 269


>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
          Length = 420

 Score = 38.9 bits (89), Expect = 0.002
 Identities = 23/92 (25%), Positives = 46/92 (50%), Gaps = 9/92 (9%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF----FLTVHQPLSK 116
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++    F    +   K
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQK 238

Query: 117 EYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 RVLTITGICIALLVVGIMCVVAY-CKTKKQRK 269


>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
          Length = 637

 Score = 38.9 bits (89), Expect = 0.002
 Identities = 23/92 (25%), Positives = 46/92 (50%), Gaps = 9/92 (9%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF----FLTVHQPLSK 116
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++    F    +   K
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQK 238

Query: 117 EYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 RVLTITGICIALLVVGIMCVVAY-CKTKKQRK 269


>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
          Length = 4655

 Score = 38.5 bits (88), Expect = 0.003
 Identities = 23/61 (37%), Positives = 32/61 (52%), Gaps = 4/61 (6%)

Query: 76   CLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVG 135
            C+HG   Y  +     C+C  GYTG  CE  F    + +S    A+ V+L IL LI V+G
Sbjct: 4383 CMHGGNCYFDETDLPKCKCPSGYTGKYCEMAF---SKGISPGTTAVAVLLTIL-LIVVIG 4438

Query: 136  S 136
            +
Sbjct: 4439 A 4439


>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
          Length = 308

 Score = 37.7 bits (86), Expect = 0.005
 Identities = 25/95 (26%), Positives = 48/95 (50%), Gaps = 12/95 (12%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRC-EHFFLTV------HQP 113
           + KC+     +C++G +C  + D+S   +  C+C+ G+TG RC E+  + V       + 
Sbjct: 25  LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL 84

Query: 114 LSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 85  YQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 118


>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
          Length = 640

 Score = 37.7 bits (86), Expect = 0.005
 Identities = 25/95 (26%), Positives = 48/95 (50%), Gaps = 12/95 (12%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRC-EHFFLTV------HQP 113
           + KC+     +C++G +C  + D+S   +  C+C+ G+TG RC E+  + V       + 
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL 238

Query: 114 LSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 YQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 272


>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
          Length = 462

 Score = 37.7 bits (86), Expect = 0.005
 Identities = 25/95 (26%), Positives = 48/95 (50%), Gaps = 12/95 (12%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRC-EHFFLTV------HQP 113
           + KC+     +C++G +C  + D+S   +  C+C+ G+TG RC E+  + V       + 
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL 238

Query: 114 LSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
             K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 YQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 272


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score = 37.7 bits (86), Expect = 0.005
 Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 20/101 (19%)

Query: 67  KCSSDMNGYCLHGQ-CIYLVDMSQNYCRCEVGYTGVRC-EHFFLTVHQP----------- 113
           KC+     YC++G  C Y+  ++Q  C+C  G+ G RC E   L ++ P           
Sbjct: 344 KCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFEL 403

Query: 114 ------LSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
                   K  + +T I + L ++ +V    Y C+  + RK
Sbjct: 404 KEAEELYQKRVLTITGICVALLVVGIVCVVAY-CKTKKQRK 443


>gi|139394621 chondroitin sulfate proteoglycan 5 (neuroglycan C)
           precursor [Homo sapiens]
          Length = 539

 Score = 37.4 bits (85), Expect = 0.006
 Identities = 23/84 (27%), Positives = 41/84 (48%), Gaps = 5/84 (5%)

Query: 75  YCLHGQCIYLVDMSQNYCRCE----VGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFL 130
           YC +G   YLV+    +CRC     + + G+RCE   +T  Q +     +  ++L++LF+
Sbjct: 380 YCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCES-IITDFQVMCVAVGSAALVLLLLFM 438

Query: 131 ITVVGSTYYFCRWYRNRKSKEPKK 154
           +TV  +   +     N K +   K
Sbjct: 439 MTVFFAKKLYLLKTENTKLRRTNK 462


>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
          Length = 590

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 17/100 (17%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF------------FL 108
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++            F+
Sbjct: 124 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFM 183

Query: 109 TVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
              +   K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 184 EAEELYQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 222


>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
          Length = 624

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 17/100 (17%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF------------FL 108
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++            F+
Sbjct: 158 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFM 217

Query: 109 TVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
              +   K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 218 EAEELYQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 256


>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
          Length = 607

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 17/100 (17%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF------------FL 108
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++            F+
Sbjct: 141 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFM 200

Query: 109 TVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
              +   K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 201 EAEELYQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 239


>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
          Length = 645

 Score = 37.0 bits (84), Expect = 0.008
 Identities = 23/100 (23%), Positives = 47/100 (47%), Gaps = 17/100 (17%)

Query: 65  ITKCSSDMNGYCLHG-QCIYLVDMS---QNYCRCEVGYTGVRCEHF------------FL 108
           + KC+     +C++G +C  + D+S   +  C+C   +TG RC+++            F+
Sbjct: 179 LVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFM 238

Query: 109 TVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRK 148
              +   K  + +T I I L ++ ++    Y C+  + RK
Sbjct: 239 EAEELYQKRVLTITGICIALLVVGIMCVVAY-CKTKKQRK 277


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.138    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,579,575
Number of Sequences: 37866
Number of extensions: 262493
Number of successful extensions: 1722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 1312
Number of HSP's gapped (non-prelim): 511
length of query: 169
length of database: 18,247,518
effective HSP length: 95
effective length of query: 74
effective length of database: 14,650,248
effective search space: 1084118352
effective search space used: 1084118352
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.