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Search of human proteins with 45504369
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
(500 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 1003 0.0
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 203 3e-52
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 203 3e-52
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 203 3e-52
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 196 5e-50
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 177 2e-44
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 169 4e-42
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 95 2e-19
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 64 2e-10
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 64 2e-10
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 64 2e-10
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 64 2e-10
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 64 4e-10
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 64 4e-10
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 64 4e-10
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 64 4e-10
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 59 1e-08
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 45 1e-04
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 45 1e-04
gi|209863002 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862998 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862994 MAP-kinase activating death domain-containing prote... 33 0.79
gi|18860873 MAP-kinase activating death domain-containing protei... 33 0.79
gi|209862987 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862983 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862979 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862975 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209862971 MAP-kinase activating death domain-containing prote... 33 0.79
gi|209571517 MAP-kinase activating death domain-containing prote... 33 0.79
gi|32401447 solute carrier family 46, member 3 isoform a [Homo s... 32 1.8
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 1003 bits (2594), Expect = 0.0
Identities = 500/500 (100%), Positives = 500/500 (100%)
Query: 1 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT 60
MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT
Sbjct: 1 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT 60
Query: 61 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA 120
RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA
Sbjct: 61 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA 120
Query: 121 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT 180
PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT
Sbjct: 121 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT 180
Query: 181 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME 240
ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME
Sbjct: 181 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME 240
Query: 241 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE 300
RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE
Sbjct: 241 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE 300
Query: 301 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG 360
ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG
Sbjct: 301 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG 360
Query: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI 420
ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI
Sbjct: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI 420
Query: 421 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT 480
KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT
Sbjct: 421 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT 480
Query: 481 LSVLYELGIIGNNKIRGCGG 500
LSVLYELGIIGNNKIRGCGG
Sbjct: 481 LSVLYELGIIGNNKIRGCGG 500
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 203 bits (516), Expect = 3e-52
Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Query: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347
V D S F++PEA ++ WV + P+I LL +T P+C K W+ +F++TF + +WI+
Sbjct: 343 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 402
Query: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407
F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 403 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 462
Query: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466
VFD+L LG+PW ++T +N + ++NSRGL Y + L S+ L +H N W+LDRK
Sbjct: 463 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 522
Query: 467 LGIVCLLSYLGLATLSVLYELGI 489
LG+ L+ Y S++ E +
Sbjct: 523 LGVYVLVLYAIFLCFSIMIEFNV 545
Score = 185 bits (470), Expect = 7e-47
Identities = 103/282 (36%), Positives = 150/282 (53%), Gaps = 42/282 (14%)
Query: 40 TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99
T + C EFP F+ +ER+ G ++++ L +YMF A++IVCD++F+PSLE I
Sbjct: 7 TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 66
Query: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159
E L LS+DVAG TFMAAGSS PEL + +GVFIT GD+G+ TI+GSA++N+L I CGL
Sbjct: 67 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 126
Query: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219
+ V L+ W + RD YTIS ++ IYD Q+ W+EG +L+++Y Y+L++ +++K
Sbjct: 127 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 186
Query: 220 INQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLS 279
+ + K G P S ++G + D Y S
Sbjct: 187 MQAFFTVKQKSIA--------------------NGNPV---NSELEAGNDFYDGSYDDPS 223
Query: 280 ISLHGLSQVSEDP-----------------PSVFNMPEADLK 304
+ L L QV E P P F PEA L+
Sbjct: 224 VPL--LGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLR 263
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 73 FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131
F ++ ++ + I Y + L II +LG+ + G TF+AAG+S P+ + + +
Sbjct: 388 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 447
Query: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184
GD+ +S +GS ++++L G+ GL + V+ S + Y++ A
Sbjct: 448 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 507
Query: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220
VLGI + + + L + + LY + LCF I I
Sbjct: 508 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 541
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
E L + + V G T +AAG+S P+ ASV+ GD+ + IVGS VF++LC +G+
Sbjct: 67 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 126
Query: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
+ + A R Y TIS+ + I+F++
Sbjct: 127 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 158
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 203 bits (516), Expect = 3e-52
Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Query: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347
V D S F++PEA ++ WV + P+I LL +T P+C K W+ +F++TF + +WI+
Sbjct: 371 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 430
Query: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407
F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 431 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 490
Query: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466
VFD+L LG+PW ++T +N + ++NSRGL Y + L S+ L +H N W+LDRK
Sbjct: 491 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 550
Query: 467 LGIVCLLSYLGLATLSVLYELGI 489
LG+ L+ Y S++ E +
Sbjct: 551 LGVYVLVLYAIFLCFSIMIEFNV 573
Score = 184 bits (467), Expect = 2e-46
Identities = 84/188 (44%), Positives = 126/188 (67%)
Query: 40 TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99
T + C EFP F+ +ER+ G ++++ L +YMF A++IVCD++F+PSLE I
Sbjct: 54 TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 113
Query: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159
E L LS+DVAG TFMAAGSS PEL + +GVFIT GD+G+ TI+GSA++N+L I CGL
Sbjct: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
Query: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219
+ V L+ W + RD YTIS ++ IYD Q+ W+EG +L+++Y Y+L++ +++K
Sbjct: 174 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 233
Query: 220 INQYIIKK 227
+ + K
Sbjct: 234 MQAFFTVK 241
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 73 FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131
F ++ ++ + I Y + L II +LG+ + G TF+AAG+S P+ + + +
Sbjct: 416 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 475
Query: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184
GD+ +S +GS ++++L G+ GL + V+ S + Y++ A
Sbjct: 476 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 535
Query: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220
VLGI + + + L + + LY + LCF I I
Sbjct: 536 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 569
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
E L + + V G T +AAG+S P+ ASV+ GD+ + IVGS VF++LC +G+
Sbjct: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
Query: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
+ + A R Y TIS+ + I+F++
Sbjct: 174 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 205
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 203 bits (516), Expect = 3e-52
Identities = 95/203 (46%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Query: 288 VSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISA 347
V D S F++PEA ++ WV + P+I LL +T P+C K W+ +F++TF + +WI+
Sbjct: 390 VEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAV 449
Query: 348 FTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSN 407
F+YI+VW+VTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSN
Sbjct: 450 FSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSN 509
Query: 408 VFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRK 466
VFD+L LG+PW ++T +N + ++NSRGL Y + L S+ L +H N W+LDRK
Sbjct: 510 VFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRK 569
Query: 467 LGIVCLLSYLGLATLSVLYELGI 489
LG+ L+ Y S++ E +
Sbjct: 570 LGVYVLVLYAIFLCFSIMIEFNV 592
Score = 185 bits (470), Expect = 7e-47
Identities = 103/282 (36%), Positives = 150/282 (53%), Gaps = 42/282 (14%)
Query: 40 TGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIIS 99
T + C EFP F+ +ER+ G ++++ L +YMF A++IVCD++F+PSLE I
Sbjct: 54 TQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKIC 113
Query: 100 ESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGL 159
E L LS+DVAG TFMAAGSS PEL + +GVFIT GD+G+ TI+GSA++N+L I CGL
Sbjct: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
Query: 160 LSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIK 219
+ V L+ W + RD YTIS ++ IYD Q+ W+EG +L+++Y Y+L++ +++K
Sbjct: 174 FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVK 233
Query: 220 INQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLS 279
+ + K G P S ++G + D Y S
Sbjct: 234 MQAFFTVKQKSIA--------------------NGNPV---NSELEAGNDFYDGSYDDPS 270
Query: 280 ISLHGLSQVSEDP-----------------PSVFNMPEADLK 304
+ L L QV E P P F PEA L+
Sbjct: 271 VPL--LGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLR 310
Score = 50.1 bits (118), Expect = 5e-06
Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 10/156 (6%)
Query: 73 FLIIVYMFMAISIVCDEYFLPSL-EIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF 131
F ++ ++ + I Y + L II +LG+ + G TF+AAG+S P+ + + +
Sbjct: 435 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 494
Query: 132 ITKGDIGISTILGSAIYNLL-GICAACGLLSNTVSTLSCWPLFRDCAAYTI------SAA 184
GD+ +S +GS ++++L G+ GL + V+ S + Y++ A
Sbjct: 495 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVAL 554
Query: 185 AVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKI 220
VLGI + + + L + + LY + LCF I I
Sbjct: 555 TVLGIHLNK--WRLDRKLGVYVLVLYAIFLCFSIMI 588
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
E L + + V G T +AAG+S P+ ASV+ GD+ + IVGS VF++LC +G+
Sbjct: 114 ERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGL 173
Query: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
+ + A R Y TIS+ + I+F++
Sbjct: 174 FAGQVVRLTWWAV--CRDSVYYTISVIVLIVFIY 205
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 196 bits (497), Expect = 5e-50
Identities = 94/211 (44%), Positives = 136/211 (64%), Gaps = 1/211 (0%)
Query: 290 EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFT 349
E P + F+ P L+ + W + P+ +L+ T P+C K W+ +F++TF S +WI+AF+
Sbjct: 432 EGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFS 491
Query: 350 YILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVF 409
Y++VWMVTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSNVF
Sbjct: 492 YMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVF 551
Query: 410 DMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLG 468
D+L LG+PW ++T ++ + +NSRGL Y L S+ VH N W+LD+KLG
Sbjct: 552 DILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLG 611
Query: 469 IVCLLSYLGLATLSVLYELGIIGNNKIRGCG 499
CLL Y S++ E + + CG
Sbjct: 612 CGCLLLYGVFLCFSIMTEFNVFTFVNLPMCG 642
Score = 193 bits (491), Expect = 3e-49
Identities = 90/181 (49%), Positives = 128/181 (70%)
Query: 42 NSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISES 101
NS C EFP FT ++RR G ++++ L +YMF A++IVCD++F+PSLE I E
Sbjct: 83 NSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICER 142
Query: 102 LGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLS 161
L LS+DVAG TFMAAGSSAPEL T+ +GVFITKGD+G+ TI+GSA++N+L I CGL +
Sbjct: 143 LHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFA 202
Query: 162 NTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKIN 221
V LS W L RD YT+S A++ IYD +V W+E +L+L+Y +Y++++ ++ I+
Sbjct: 203 GQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIH 262
Query: 222 Q 222
Q
Sbjct: 263 Q 263
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
E L + + V G T +AAG+S P+ SV+ KGD+ + IVGS VF++LC +G+
Sbjct: 141 ERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL 200
Query: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
+ S+ + R Y T+S+ I+F++
Sbjct: 201 FAGQVVALSSWCLL--RDSIYYTLSVIALIVFIY 232
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/130 (26%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 97 IISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYN-LLGICA 155
II +LG+ + G TF+AAG+S P+ + + + GD+ +S +GS +++ L+G+
Sbjct: 500 IIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGL 559
Query: 156 ACGLLSNTVSTLSCWPLFRDCAAYTIS--AAAVLGIIYDNQVYWYE-----GALLLLIYG 208
L + V S L Y++ A+V ++ + ++ G LL+YG
Sbjct: 560 PWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYG 619
Query: 209 LYVLVLCFDI 218
++ LCF I
Sbjct: 620 VF---LCFSI 626
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 177 bits (450), Expect = 2e-44
Identities = 81/192 (42%), Positives = 125/192 (65%)
Query: 33 PQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFL 92
PQ G S ++P+ F+ +ERR G II++ + ++YMF+A++IVCDE+F+
Sbjct: 99 PQPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFV 158
Query: 93 PSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLG 152
PSL +I+E LG+S DVAG TFMAAG SAPEL T+ +GVFI ++GI TI+GSA++N+L
Sbjct: 159 PSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 218
Query: 153 ICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVL 212
+ C L S + L+ WPLFRD + Y + ++ DN + W+E LLL Y YV+
Sbjct: 219 VIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVV 278
Query: 213 VLCFDIKINQYI 224
+ F++++ +++
Sbjct: 279 FMKFNVQVEKWV 290
Score = 155 bits (393), Expect = 6e-38
Identities = 83/198 (41%), Positives = 123/198 (62%), Gaps = 2/198 (1%)
Query: 290 EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFT 349
ED P P K++ +++ PI+ L++T PD RK + +F ITFF S WI+ F+
Sbjct: 455 EDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFS 514
Query: 350 YILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVF 409
Y++VW GET+ I + +MGLT+LAAGTSIPD I SV+VARKG GDMA+S+ VGSN+F
Sbjct: 515 YLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIF 574
Query: 410 DM-LCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLG 468
D+ + L +PW + T I+ P V+S GL + L I ++F+ L++ W++++ LG
Sbjct: 575 DITVGLPLPWLLYTV-IHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILG 633
Query: 469 IVCLLSYLGLATLSVLYE 486
+ Y +SVL E
Sbjct: 634 FIMFGLYFVFLVVSVLLE 651
Score = 46.2 bits (108), Expect = 7e-05
Identities = 33/134 (24%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 98 ISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAAC 157
+ E++G+S+++ G T +AAG+S P+L+T+ + GD+ +S+ +GS I+++
Sbjct: 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLP 583
Query: 158 GLLSNTVS-----TLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALL-LLIYGLYV 211
LL + +S LF CA + + I+ W +L +++GLY
Sbjct: 584 WLLYTVIHRFQPVAVSSNGLF--CAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 641
Query: 212 LVLCFDIKINQYII 225
+ L + + I+
Sbjct: 642 VFLVVSVLLEDRIL 655
Score = 39.3 bits (90), Expect = 0.008
Identities = 21/57 (36%), Positives = 32/57 (56%)
Query: 356 VTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML 412
+T+ E L I D V G T +AAG S P+ S++ ++ + IVGS VF++L
Sbjct: 161 LTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 169 bits (429), Expect = 4e-42
Identities = 84/203 (41%), Positives = 130/203 (64%), Gaps = 9/203 (4%)
Query: 22 TAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFM 81
TA LP + P LP + + + P E+P F+ +ERR G ++++ ++Y+F+
Sbjct: 413 TALLPEELSPSPSVLPPSLPD-----LHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFV 467
Query: 82 AISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGIST 141
A++IVCDEYF+P+L +I++ L +S+DVAG TFMAAG SAPEL T+ +GVFI+ ++GI T
Sbjct: 468 ALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGT 527
Query: 142 ILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGA 201
I+GSA++N+L + C L S + L+ WPLFRD + Y + ++ D+ + W+E
Sbjct: 528 IVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESL 587
Query: 202 LLLLIYGLYVLVLCFDIKINQYI 224
LLLL Y YV F +K N++I
Sbjct: 588 LLLLAYAFYV----FTMKWNKHI 606
Score = 157 bits (397), Expect = 2e-38
Identities = 85/203 (41%), Positives = 130/203 (64%), Gaps = 3/203 (1%)
Query: 289 SEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAF 348
+E+P S+ + PE K+ ++ LPI+ L+LT PD R++ + +FV TF S +WI+ F
Sbjct: 893 NEEPLSL-DWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMF 951
Query: 349 TYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNV 408
+Y++VW GET+ I + +MGLT+LAAGTSIPD I SV+VARKG GDMA+S+ VGSN+
Sbjct: 952 SYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 1011
Query: 409 FDM-LCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKL 467
FD+ + L +PW + + ING P V+S GL + L + ++F+ ++ W++++ L
Sbjct: 1012 FDITVGLPVPWLL-FSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKIL 1070
Query: 468 GIVCLLSYLGLATLSVLYELGII 490
G L Y +SV+ E II
Sbjct: 1071 GFTMFLLYFVFLIISVMLEDRII 1093
Score = 46.6 bits (109), Expect = 5e-05
Identities = 32/132 (24%), Positives = 65/132 (49%), Gaps = 4/132 (3%)
Query: 98 ISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAAC 157
+ E++G+S+++ G T +AAG+S P+L+T+ + GD+ +S+ +GS I+++
Sbjct: 962 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVP 1021
Query: 158 GLLSNTVSTLSCWPLFRD---CAAYTISAAAVLGIIYDNQVYWYEGALL-LLIYGLYVLV 213
LL + ++ L P+ + CA + + I W +L ++ LY +
Sbjct: 1022 WLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVF 1081
Query: 214 LCFDIKINQYII 225
L + + II
Sbjct: 1082 LIISVMLEDRII 1093
Score = 39.3 bits (90), Expect = 0.008
Identities = 37/137 (27%), Positives = 60/137 (43%), Gaps = 24/137 (17%)
Query: 276 SQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFV 335
S L SL L E PP +F++ E +R WV+ + F
Sbjct: 425 SVLPPSLPDLHPKGEYPPDLFSVEE---RRQGWVVL--------------------HVFG 461
Query: 336 ITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGK 395
+ + A+ I Y + + IT + L+I + V G T +AAG S P+ S++
Sbjct: 462 MMYVFVALAIVCDEYFVPALGVIT-DKLQISEDVAGATFMAAGGSAPELFTSLIGVFISH 520
Query: 396 GDMAMSNIVGSNVFDML 412
++ + IVGS VF++L
Sbjct: 521 SNVGIGTIVGSAVFNIL 537
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 94.7 bits (234), Expect = 2e-19
Identities = 110/498 (22%), Positives = 203/498 (40%), Gaps = 94/498 (18%)
Query: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFL 128
+ +Y ++Y+F+ + + ++F P+L IS +L LS +VAG TF+A G+ AP++ +A +
Sbjct: 100 VTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALV 159
Query: 129 GVFIT-KGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVL 187
+ + + G+ + L+ A G+ + P FRD Y ++
Sbjct: 160 AFSDPHTAGLALGALFGAGV--LVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTF 217
Query: 188 GIIYDNQV--YWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQ 245
+++ +V W G L L ++ + ++LC I Q ++ S C S+ +
Sbjct: 218 LMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQ---RRGSLFCPMPVTPEILSDSE 274
Query: 246 PLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKR 305
ED R S T+S + ++ Y L +Q+ + + + K
Sbjct: 275 -----ED------RVSSNTNSYDYGDE--YRPLFFYQETTAQILVRALNPLDYMKWRRKS 321
Query: 306 IFW----VLSLPIITLLFLTT----PDCRKKFWKN-----YFVITFFMSAIWISAFTY-- 350
+W V LP+ LL LT PD + WK + VI+ + + + + TY
Sbjct: 322 AYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGV 381
Query: 351 ------ILVWMVTI---------------------------------------------- 358
+ VW+V +
Sbjct: 382 YEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVV 441
Query: 359 -----TGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC 413
G + +TV+GLTLLA G SI D + +AR+G MA S G +F++L
Sbjct: 442 NILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILV 501
Query: 414 -LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL 472
+G+ ++ + + E + + + +L +S++F ++V ++L R G L
Sbjct: 502 GVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLL 561
Query: 473 LSYLGLATLSVLYELGII 490
L YL +++L E G+I
Sbjct: 562 LFYLNFLVVALLTEFGVI 579
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
Query: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 735 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 794
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 795 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 843
Score = 35.4 bits (80), Expect = 0.12
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
Query: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 732 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 791
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 792 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 840
Score = 35.4 bits (80), Expect = 0.12
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
Query: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 736 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 795
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 796 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 844
Score = 35.4 bits (80), Expect = 0.12
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
Query: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 738 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 797
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 798 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 846
Score = 35.4 bits (80), Expect = 0.12
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 63.5 bits (153), Expect = 4e-10
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 28/169 (16%)
Query: 71 IYFLIIVYMFMAISIVCDEYFLPSLEIISESLG------------------LSQDVAGTT 112
+YF+ +VYMF+ +SI+ D F+ S+E+I+ ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 113 FMAAGSSAPELVTAFLGVF---ITKGDIGISTILGSAIYNLLGICAACGLL--SNTVSTL 167
MA GSSAPE++ + + V T GD+G STI+GSA +N+ I A C + +
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 168 SCWPLFRDCAAYTISAAA----VLGIIYDNQVYWYEGALLLLIYGLYVL 212
+F AA++I A +L +I V +EG L + + V+
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVV 247
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 306 IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEI 365
+FW +LF P ++W + F +S + I T + + + G T+ +
Sbjct: 783 VFW-------KVLFAFVPPT--EYWNGW--ACFIVSILMIGLLTAFIGDLASHFGCTIGL 831
Query: 366 PDTVMGLTLLAAGTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTA 423
D+V + +A GTS+PDT AS + A + + D ++ N+ GSN ++ L +G+ W I A
Sbjct: 832 KDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI--A 889
Query: 424 FINGSAPAEVNSRGLTYITISLNISIIFLFLAV 456
I +A E + S+ + IF F+ V
Sbjct: 890 AIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 922
Score = 35.8 bits (81), Expect = 0.093
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 339 FMSAIWISAFTYILVWMVTITGETLEIP-----DTVMGLTLLAAGTSIPDTIASVLVA-- 391
FMS+I + + + GET + +TV LTL+A G+S P+ + SV+
Sbjct: 99 FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCG 158
Query: 392 -RKGKGDMAMSNIVGSNVFDMLCL 414
GD+ S IVGS F+M +
Sbjct: 159 HNFTAGDLGPSTIVGSAAFNMFII 182
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 63.5 bits (153), Expect = 4e-10
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 28/169 (16%)
Query: 71 IYFLIIVYMFMAISIVCDEYFLPSLEIISESLG------------------LSQDVAGTT 112
+YF+ +VYMF+ +SI+ D F+ S+E+I+ ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 113 FMAAGSSAPELVTAFLGVF---ITKGDIGISTILGSAIYNLLGICAACGLL--SNTVSTL 167
MA GSSAPE++ + + V T GD+G STI+GSA +N+ I A C + +
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 168 SCWPLFRDCAAYTISAAA----VLGIIYDNQVYWYEGALLLLIYGLYVL 212
+F AA++I A +L +I V +EG L + + V+
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVV 247
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 306 IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEI 365
+FW +LF P ++W + F +S + I T + + + G T+ +
Sbjct: 747 VFW-------KVLFAFVPPT--EYWNGW--ACFIVSILMIGLLTAFIGDLASHFGCTIGL 795
Query: 366 PDTVMGLTLLAAGTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTA 423
D+V + +A GTS+PDT AS + A + + D ++ N+ GSN ++ L +G+ W I A
Sbjct: 796 KDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI--A 853
Query: 424 FINGSAPAEVNSRGLTYITISLNISIIFLFLAV 456
I +A E + S+ + IF F+ V
Sbjct: 854 AIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 886
Score = 35.8 bits (81), Expect = 0.093
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 339 FMSAIWISAFTYILVWMVTITGETLEIP-----DTVMGLTLLAAGTSIPDTIASVLVA-- 391
FMS+I + + + GET + +TV LTL+A G+S P+ + SV+
Sbjct: 99 FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCG 158
Query: 392 -RKGKGDMAMSNIVGSNVFDMLCL 414
GD+ S IVGS F+M +
Sbjct: 159 HNFTAGDLGPSTIVGSAAFNMFII 182
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 63.5 bits (153), Expect = 4e-10
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 28/169 (16%)
Query: 71 IYFLIIVYMFMAISIVCDEYFLPSLEIISESLG------------------LSQDVAGTT 112
+YF+ +VYMF+ +SI+ D F+ S+E+I+ ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 113 FMAAGSSAPELVTAFLGVF---ITKGDIGISTILGSAIYNLLGICAACGLL--SNTVSTL 167
MA GSSAPE++ + + V T GD+G STI+GSA +N+ I A C + +
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 168 SCWPLFRDCAAYTISAAA----VLGIIYDNQVYWYEGALLLLIYGLYVL 212
+F AA++I A +L +I V +EG L + + V+
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVV 247
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 306 IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEI 365
+FW +LF P ++W + F +S + I T + + + G T+ +
Sbjct: 770 VFW-------KVLFAFVPPT--EYWNGW--ACFIVSILMIGLLTAFIGDLASHFGCTIGL 818
Query: 366 PDTVMGLTLLAAGTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTA 423
D+V + +A GTS+PDT AS + A + + D ++ N+ GSN ++ L +G+ W I A
Sbjct: 819 KDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI--A 876
Query: 424 FINGSAPAEVNSRGLTYITISLNISIIFLFLAV 456
I +A E + S+ + IF F+ V
Sbjct: 877 AIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 909
Score = 35.8 bits (81), Expect = 0.093
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 339 FMSAIWISAFTYILVWMVTITGETLEIP-----DTVMGLTLLAAGTSIPDTIASVLVA-- 391
FMS+I + + + GET + +TV LTL+A G+S P+ + SV+
Sbjct: 99 FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCG 158
Query: 392 -RKGKGDMAMSNIVGSNVFDMLCL 414
GD+ S IVGS F+M +
Sbjct: 159 HNFTAGDLGPSTIVGSAAFNMFII 182
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 63.5 bits (153), Expect = 4e-10
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 28/169 (16%)
Query: 71 IYFLIIVYMFMAISIVCDEYFLPSLEIISESLG------------------LSQDVAGTT 112
+YF+ +VYMF+ +SI+ D F+ S+E+I+ ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADR-FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 113 FMAAGSSAPELVTAFLGVF---ITKGDIGISTILGSAIYNLLGICAACGLL--SNTVSTL 167
MA GSSAPE++ + + V T GD+G STI+GSA +N+ I A C + +
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 168 SCWPLFRDCAAYTISAAA----VLGIIYDNQVYWYEGALLLLIYGLYVL 212
+F AA++I A +L +I V +EG L + + V+
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVV 247
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 306 IFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEI 365
+FW +LF P ++W + F +S + I T + + + G T+ +
Sbjct: 778 VFW-------KVLFAFVPPT--EYWNGW--ACFIVSILMIGLLTAFIGDLASHFGCTIGL 826
Query: 366 PDTVMGLTLLAAGTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTA 423
D+V + +A GTS+PDT AS + A + + D ++ N+ GSN ++ L +G+ W I A
Sbjct: 827 KDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI--A 884
Query: 424 FINGSAPAEVNSRGLTYITISLNISIIFLFLAV 456
I +A E + S+ + IF F+ V
Sbjct: 885 AIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 917
Score = 35.8 bits (81), Expect = 0.093
Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 8/84 (9%)
Query: 339 FMSAIWISAFTYILVWMVTITGETLEIP-----DTVMGLTLLAAGTSIPDTIASVLVA-- 391
FMS+I + + + GET + +TV LTL+A G+S P+ + SV+
Sbjct: 99 FMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCG 158
Query: 392 -RKGKGDMAMSNIVGSNVFDMLCL 414
GD+ S IVGS F+M +
Sbjct: 159 HNFTAGDLGPSTIVGSAAFNMFII 182
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 58.9 bits (141), Expect = 1e-08
Identities = 35/109 (32%), Positives = 61/109 (55%), Gaps = 22/109 (20%)
Query: 70 IIYFLIIVYMFMAISIVCDEYFLPSLEIISE--------------SLGL----SQDVAGT 111
++YF+ +VYMF+ +SI+ D F+ ++E+I+ S+G ++ V+
Sbjct: 73 VVYFVAMVYMFLGVSIIADR-FMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
Query: 112 TFMAAGSSAPELVTAFL---GVFITKGDIGISTILGSAIYNLLGICAAC 157
T MA GSSAPE++ + + G G++G TI+GSA +N+ + A C
Sbjct: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC 180
Score = 51.2 bits (121), Expect = 2e-06
Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 19/143 (13%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T ++ + + G T+ + D+V + +A
Sbjct: 732 FWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVAL 791
Query: 378 GTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTAF--INGSAPAEV 433
GTSIPDT AS + A + + D ++ N+ GSN ++ L LG+ W + + + G P EV
Sbjct: 792 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQG-RPFEV 850
Query: 434 NSRGLTYITISLNISIIFLFLAV 456
+ L + S+ + +F F+ +
Sbjct: 851 RTGTLAF---SVTLFTVFAFVGI 870
Score = 32.0 bits (71), Expect = 1.3
Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 367 DTVMGLTLLAAGTSIPDTIASVLVA---RKGKGDMAMSNIVGSNVFDM 411
+TV LTL+A G+S P+ + SV+ G++ IVGS F+M
Sbjct: 126 ETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNM 173
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 95 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 154
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 155 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 203
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 109 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 168
Query: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 169 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 217
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1365 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1421
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1422 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1450
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1368 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1424
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1425 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1453
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1471 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1527
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1528 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1556
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1471 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1527
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1528 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1556
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1369 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1425
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1426 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1454
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1432 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1488
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1489 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1517
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1369 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1425
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1426 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1454
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1389 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1445
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1446 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1474
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1412 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1468
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1469 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1497
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 32.7 bits (73), Expect = 0.79
Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 11/89 (12%)
Query: 187 LGIIYDNQVYWYEGALLLLIYGLYVLVLCF------DIKINQYIIKKCSPCCACLAKAME 240
+G +Y+ +WYE L+ + Y VLC + ++N++ KKC C+ +ME
Sbjct: 1411 IGTVYER--WWYE-KLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSME 1467
Query: 241 R--SEQQPLMGWEDEGQPFIRRQSRTDSG 267
R + QQ + + G F + +T G
Sbjct: 1468 RAAARQQSIKPGPELGGEFPVQDLKTGEG 1496
>gi|32401447 solute carrier family 46, member 3 isoform a [Homo
sapiens]
Length = 461
Score = 31.6 bits (70), Expect = 1.8
Identities = 36/168 (21%), Positives = 66/168 (39%), Gaps = 26/168 (15%)
Query: 70 IIYFLIIVYMFMAISI--VCDEYFLPSLEIISES-LGLSQDVAGTTFMAA-------GSS 119
++ F +I Y F+ I I + Y L S +E +G + +F+ +
Sbjct: 262 LLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYC 321
Query: 120 APELVTAFLGVFITKGDIGISTILGSAI----------YNLLGICAACGLLSNTVSTLSC 169
++ AF+G+F T + ++ + + + ++ +LS V +
Sbjct: 322 MEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQ 381
Query: 170 WPLFRDCAAYT-----ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVL 212
LF C A+ ++A + IY V WY G LL GL +L
Sbjct: 382 GTLFA-CIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLL 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,125,931
Number of Sequences: 37866
Number of extensions: 777546
Number of successful extensions: 2190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2084
Number of HSP's gapped (non-prelim): 84
length of query: 500
length of database: 18,247,518
effective HSP length: 106
effective length of query: 394
effective length of database: 14,233,722
effective search space: 5608086468
effective search space used: 5608086468
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.