Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 45387945
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
(893 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45387945 family with sequence similarity 62 (C2 domain contai... 1779 0.0
gi|103472031 family with sequence similarity 62 (C2 domain conta... 652 0.0
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 592 e-169
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 80 1e-14
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 80 1e-14
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 79 2e-14
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 79 2e-14
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens] 78 3e-14
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens] 78 3e-14
gi|47078261 double C2-like domains, alpha [Homo sapiens] 77 5e-14
gi|211059429 synaptotagmin II [Homo sapiens] 76 2e-13
gi|31543670 synaptotagmin II [Homo sapiens] 76 2e-13
gi|238550198 synaptotagmin III [Homo sapiens] 76 2e-13
gi|238550196 synaptotagmin III [Homo sapiens] 76 2e-13
gi|14150054 synaptotagmin III [Homo sapiens] 76 2e-13
gi|6005997 double C2-like domains, beta [Homo sapiens] 75 3e-13
gi|209447073 synaptotagmin I [Homo sapiens] 74 5e-13
gi|5032139 synaptotagmin I [Homo sapiens] 74 5e-13
gi|209447070 synaptotagmin I [Homo sapiens] 74 5e-13
gi|92859638 synaptotagmin V [Homo sapiens] 74 5e-13
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 72 2e-12
gi|28376627 synaptotagmin IX [Homo sapiens] 72 3e-12
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 71 5e-12
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 71 5e-12
gi|110227631 synaptotagmin-like 3 [Homo sapiens] 70 7e-12
gi|216548478 synaptotagmin XI [Homo sapiens] 70 9e-12
gi|150170670 piccolo isoform 2 [Homo sapiens] 69 1e-11
gi|150378539 piccolo isoform 1 [Homo sapiens] 69 1e-11
gi|39752671 synaptotagmin X [Homo sapiens] 69 1e-11
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 69 2e-11
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 1779 bits (4608), Expect = 0.0
Identities = 893/893 (100%), Positives = 893/893 (100%)
Query: 1 MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAG 60
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAG
Sbjct: 1 MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAG 60
Query: 61 AGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAW 120
AGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAW
Sbjct: 61 AGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAW 120
Query: 121 CRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF 180
CRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
Sbjct: 121 CRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF 180
Query: 181 ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDL 240
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDL
Sbjct: 181 ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDL 240
Query: 241 QISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLE 300
QISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLE
Sbjct: 241 QISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLE 300
Query: 301 INWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR 360
INWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR
Sbjct: 301 INWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLR 360
Query: 361 IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYE 420
IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYE
Sbjct: 361 IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYE 420
Query: 421 HPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTL 480
HPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTL
Sbjct: 421 HPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTL 480
Query: 481 MPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGH 540
MPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGH
Sbjct: 481 MPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGH 540
Query: 541 KAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSED 600
KAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSED
Sbjct: 541 KAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSED 600
Query: 601 MTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKS 660
MTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKS
Sbjct: 601 MTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKS 660
Query: 661 HMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHIS 720
HMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHIS
Sbjct: 661 HMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHIS 720
Query: 721 VKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVH 780
VKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVH
Sbjct: 721 VKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVH 780
Query: 781 ACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRR 840
ACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRR
Sbjct: 781 ACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRR 840
Query: 841 TLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT 893
TLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT
Sbjct: 841 TLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT 893
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 652 bits (1682), Expect = 0.0
Identities = 365/898 (40%), Positives = 538/898 (59%), Gaps = 81/898 (9%)
Query: 53 RGEGPEAGAGGAGGRAAPENPGGVLSVE---LPGLLAQLARSFALLLPVYALGYLGLSFS 109
R E P A G A PG L + LP L + R L PVY GYLGLS +
Sbjct: 2 RAEEPCA-PGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT 60
Query: 110 WVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEW 169
W+LL L W RR+R K RL A L++E + +R LPAW+HFPD ER EW
Sbjct: 61 WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW 120
Query: 170 LNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTE 229
NK + WP++ +E FRE +EP +R + HL TF+FTK+ GQ+ R+NGVK +T
Sbjct: 121 ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN 180
Query: 230 NVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGAL 289
++R++ +DLQI ++G+CEI +E+++ +AGV IQ+ GT+RVILEPL+ D P VGA+
Sbjct: 181 TCNRRRVTVDLQICYIGDCEISVELQK--IQAGVNGIQLQGTLRVILEPLLVDKPFVGAV 238
Query: 290 SIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQ 349
++FFL+KP L+INWTGLTNLLD PG+N +SD+++ D+I+ +LVLPNR+TVP+ + +
Sbjct: 239 TVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTN 298
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPK 409
LRFP+P GV+R+H +EA+ L KD +L ++GKSDPY + +G Q F+SR I NL+P
Sbjct: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPT 356
Query: 410 WNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKG 469
WNEV+E +VYE PGQ+LE++L+DED D+DDFLGSL I L +V R++DEWF L++ G
Sbjct: 357 WNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSG 416
Query: 470 KLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLP-------- 521
+LHLRLEWL+L+ + +VLT + + GLS+A+L+++L+SA NLP
Sbjct: 417 RLHLRLEWLSLLTD----QEVLT-------EDHGGLSTAILVVFLESACNLPRNPFDYLN 465
Query: 522 -----------SGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQ 570
+ K+S +P+ V++SVG K SK +PVW + F+FF+HN +
Sbjct: 466 GEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATE 525
Query: 571 DLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLE 630
L ++V D+ +C+LG L+VPL Q+L D+T+ QRFQL +SG +S I M++ LR L +E
Sbjct: 526 RLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVE 585
Query: 631 KRERPPDHQHSAQVKRPSV------SKEGRKTSIK----SHMSGSPGPGGS------NTA 674
+RE + +K+ + + +G K + + + P P +T
Sbjct: 586 ERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTT 645
Query: 675 PSTPVIGGSDKPGMEEKAQPP---EAGPQGLHDLGRSSSSLLA--------SPGHISVKE 723
+T + +P +E P ++ + +G S SPG I
Sbjct: 646 TTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPR 705
Query: 724 P---------------TPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRH 768
P PS++S SL + +L +E G L + LG+IQLT+R+
Sbjct: 706 PMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGG-DLRRRQLGEIQLTVRY 764
Query: 769 SSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSF 828
R L V+++ CRNL + G+DPYVR+YLLP+++ + R+KT V +KTL P+FD++F
Sbjct: 765 VCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETF 824
Query: 829 DFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDG 886
+F V + EV++R+LDVAVKNS S + LGKVL+ L+ E+L KG++QWY+LT +G
Sbjct: 825 EFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNG 882
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 592 bits (1526), Expect = e-169
Identities = 304/609 (49%), Positives = 428/609 (70%), Gaps = 14/609 (2%)
Query: 28 PGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQ 87
PG S P A A P+ G+GG P PG + E +L
Sbjct: 5 PGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQ-----PAGPGA--AGEALAVLTS 57
Query: 88 LARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVR 147
R +L+PVY G +GLS +VL LAL RR R K L A LL+DEE++
Sbjct: 58 FGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTA 117
Query: 148 --LGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLS 205
L + +LPAWV FPD E+AEWLNK V +WPF+ Q++EKL ET+ PAVRG+N HL
Sbjct: 118 KTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQ 177
Query: 206 TFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKS 265
TF+FT+V++G++PLRI GVKV+ K QI+LDL IS+VG+ +ID+E+K+YFC+AGVK
Sbjct: 178 TFTFTRVELGEKPLRIIGVKVHPGQ-RKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKG 236
Query: 266 IQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILD 325
+Q+HG +RVILEPLIGD+P VGA+S+FF+R+P L+INWTG+TNLLD+PGL+ LSDT+I+D
Sbjct: 237 MQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMD 296
Query: 326 IISNYLVLPNRITVPLVSEVQ-IAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKS 384
I+ +LVLPNR+ VPLV ++Q +AQLR P+P+G++RIH + A+ L KD Y+KGL++GKS
Sbjct: 297 SIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKS 356
Query: 385 DPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSL 444
DPY ++R+G Q F SRVI E L+P+W E YE +V+E PGQE+E+E+FD+DPDKDDFLG +
Sbjct: 357 DPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRM 416
Query: 445 MIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDG 504
+D+ +V + +LD+WF L + +G++HLRLEWL+L+ +A L++VL D
Sbjct: 417 KLDVGKVLQASVLDDWFPL-QGGQGQVHLRLEWLSLLSDAEKLEQVL-QWNWGVSSRPDP 474
Query: 505 LSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFI 564
S+A+L++YLD A++LP KK + PNP+VQ+S+ QESK Y TN PVWEE F FF+
Sbjct: 475 PSAAILVVYLDRAQDLPL-KKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFL 533
Query: 565 HNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIAL 624
+P+ Q+L+V+V+D+ +LG L +PL++LLT+ ++ + Q FQLS+SGPNS + MK+ +
Sbjct: 534 QDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVM 593
Query: 625 RVLHLEKRE 633
R+L+L+ E
Sbjct: 594 RILYLDSSE 602
Score = 226 bits (575), Expect = 1e-58
Identities = 123/308 (39%), Positives = 192/308 (62%), Gaps = 5/308 (1%)
Query: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEAL 417
VLRIH +EAQDL KD +L GLVKGKSDPY +++ + F+S V++E+L+P+WNEV+E +
Sbjct: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
Query: 418 VYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEW 477
V PGQELE+E+FD+D DKDDFLG + L V LDEW TL++VP G+LHLRLE
Sbjct: 708 VTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLER 767
Query: 478 LTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMS 537
LT P A+ L++VL + Q + L++ALL +Y++ A +LP +K + + +P ++
Sbjct: 768 LTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPL-RKGTKHLSPYATLT 826
Query: 538 VGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLT 597
VG + ++K +T+ PVW+E+ +F I P + LE++VR E LG+L +PLS+LL
Sbjct: 827 VGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGV-LGSLSLPLSELLV 885
Query: 598 SEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTS 657
++ + + + F LS+ ++ ++ + V + H HS S+S+E +
Sbjct: 886 ADQLCLDRWFTLSSGQGQVLLRAQLGILV---SQHSGVEAHSHSYSHSSSSLSEEPELSG 942
Query: 658 IKSHMSGS 665
H++ S
Sbjct: 943 GPPHITSS 950
Score = 139 bits (349), Expect = 2e-32
Identities = 74/183 (40%), Positives = 111/183 (60%), Gaps = 9/183 (4%)
Query: 703 HDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQI 762
H SSSSL P + P I S + ELRQRL +++ PLGQ+
Sbjct: 925 HSYSHSSSSLSEEP---ELSGGPPHITS------SAPELRQRLTHVDSPLEAPAGPLGQV 975
Query: 763 QLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNP 822
+LT+ + S+ KL+ +VH CR+L D DPYV + LLPDK R +R+T K+TL+P
Sbjct: 976 KLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSP 1035
Query: 823 VFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDL 882
F++ F++ + L E QRR LDV+VK++ F+S+++ LLGKV + LA +L++G +WYDL
Sbjct: 1036 EFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDL 1095
Query: 883 TED 885
++
Sbjct: 1096 MDN 1098
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 79.7 bits (195), Expect = 1e-14
Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 32/259 (12%)
Query: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-GNQIFQSRVIKENLSPKWNEVYEA 416
+L IH E ++L +D G SDPY ++ G +++S+VI +NL+P W+E+
Sbjct: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIV-V 247
Query: 417 LVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDE----------- 465
L + Q+L ++++D D DF+GS + L ++E R + L++
Sbjct: 248 LPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
Query: 466 ------VPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARN 519
V K R W +++ ++ +++ + + L + ++ + L +N
Sbjct: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
Query: 520 LPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEV--- 576
+ G S VQ+ +G + +SK K+ P W+E F F + + L++EV
Sbjct: 368 VSGG----SMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
Query: 577 RDEQHQCSLGNLKVPLSQL 595
+++H+ LG KV +S L
Sbjct: 424 DNKKHEERLGTCKVDISAL 442
Score = 63.5 bits (153), Expect = 8e-10
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 357 GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEA 416
G+L++ ++A DL D GKSDP+ ++ +GN Q+ + +NL+P+WN+V+
Sbjct: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVF-T 561
Query: 417 LVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEV 451
+ LE+ +FDED DK DFLG + I L+ +
Sbjct: 562 FPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 597
Score = 30.4 bits (67), Expect = 7.7
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 10/94 (10%)
Query: 776 IVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLP 835
+ V+ A L A SDP+ + L D R +TH K LNP +++ F F +
Sbjct: 513 VKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPI--- 564
Query: 836 EVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALAS 869
+ L+V V + G K LGKV + L S
Sbjct: 565 KDIHDVLEVTVFDEDG--DKPPDFLGKVAIPLLS 596
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 79.7 bits (195), Expect = 1e-14
Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 32/259 (12%)
Query: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-GNQIFQSRVIKENLSPKWNEVYEA 416
+L IH E ++L +D G SDPY ++ G +++S+VI +NL+P W+E+
Sbjct: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIV-V 247
Query: 417 LVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDE----------- 465
L + Q+L ++++D D DF+GS + L ++E R + L++
Sbjct: 248 LPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
Query: 466 ------VPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARN 519
V K R W +++ ++ +++ + + L + ++ + L +N
Sbjct: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
Query: 520 LPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEV--- 576
+ G S VQ+ +G + +SK K+ P W+E F F + + L++EV
Sbjct: 368 VSGG----SMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
Query: 577 RDEQHQCSLGNLKVPLSQL 595
+++H+ LG KV +S L
Sbjct: 424 DNKKHEERLGTCKVDISAL 442
Score = 63.5 bits (153), Expect = 8e-10
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 357 GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEA 416
G+L++ ++A DL D GKSDP+ ++ +GN Q+ + +NL+P+WN+V+
Sbjct: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVF-T 561
Query: 417 LVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEV 451
+ LE+ +FDED DK DFLG + I L+ +
Sbjct: 562 FPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 597
Score = 30.4 bits (67), Expect = 7.7
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 10/94 (10%)
Query: 776 IVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLP 835
+ V+ A L A SDP+ + L D R +TH K LNP +++ F F +
Sbjct: 513 VKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPI--- 564
Query: 836 EVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALAS 869
+ L+V V + G K LGKV + L S
Sbjct: 565 KDIHDVLEVTVFDEDG--DKPPDFLGKVAIPLLS 596
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 79.0 bits (193), Expect = 2e-14
Identities = 69/261 (26%), Positives = 121/261 (46%), Gaps = 28/261 (10%)
Query: 356 KGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYE 415
+G++ I IE +DL+ D+ G SDPY R+G+Q ++S+++ + L+P+W E ++
Sbjct: 248 RGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFD 301
Query: 416 ALVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHL- 473
+YE G ++I +D+D K DDF+G +DL + +E+ L+E G+ HL
Sbjct: 302 FHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLV 358
Query: 474 RLEWLTLMPNASNLDKVLTDIKADKDQA------------NDGLSSALLILYLDSARNLP 521
L LT S D + ++ K++ ++ L + + A L
Sbjct: 359 LLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLM 418
Query: 522 SGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQH 581
+ ++ +P + + + + YK P W + FTF I + LEV V DE
Sbjct: 419 AA-DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
Query: 582 QCS---LGNLKVPLSQLLTSE 599
S LG + +PL + E
Sbjct: 477 DRSADFLGKVAIPLLSIQNGE 497
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/86 (37%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 382 GKSDPYGIIRVGN-QIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPD-KDD 439
G SDPY ++G ++F+S++I +NL+P W E ++ +H + L I++FD D +DD
Sbjct: 59 GTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEE-KACILVDHLREPLYIKVFDYDFGLQDD 117
Query: 440 FLGSLMIDLIEVEKERLLDEWFTLDE 465
F+GS +DL ++E R D TL +
Sbjct: 118 FMGSAFLDLTQLELNRPTDVTLTLKD 143
Score = 38.5 bits (88), Expect = 0.028
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 7/91 (7%)
Query: 524 KKISSN--PNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDE-- 579
K + SN +P V+ +GH+ +SKI KT P W E F F ++ + +++ D+
Sbjct: 262 KAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDA 321
Query: 580 -QHQCSLGNLKVPLSQLLTSEDMTVSQRFQL 609
+ +G +V LS L S + T QL
Sbjct: 322 GKRDDFIGRCQVDLSAL--SREQTHKLELQL 350
Score = 31.2 bits (69), Expect = 4.5
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 783 RNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
R+L A +G SDPYV+ L K +S + KTLNP + + FDF
Sbjct: 259 RDLKAMDSNGLSDPYVKFRLGHQKYKS-----KIMPKTLNPQWREQFDF 302
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 79.0 bits (193), Expect = 2e-14
Identities = 69/261 (26%), Positives = 121/261 (46%), Gaps = 28/261 (10%)
Query: 356 KGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYE 415
+G++ I IE +DL+ D+ G SDPY R+G+Q ++S+++ + L+P+W E ++
Sbjct: 469 RGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFD 522
Query: 416 ALVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHL- 473
+YE G ++I +D+D K DDF+G +DL + +E+ L+E G+ HL
Sbjct: 523 FHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLV 579
Query: 474 RLEWLTLMPNASNLDKVLTDIKADKDQA------------NDGLSSALLILYLDSARNLP 521
L LT S D + ++ K++ ++ L + + A L
Sbjct: 580 LLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLM 639
Query: 522 SGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQH 581
+ ++ +P + + + + YK P W + FTF I + LEV V DE
Sbjct: 640 AA-DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 697
Query: 582 QCS---LGNLKVPLSQLLTSE 599
S LG + +PL + E
Sbjct: 698 DRSADFLGKVAIPLLSIQNGE 718
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/86 (37%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 382 GKSDPYGIIRVGN-QIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPD-KDD 439
G SDPY ++G ++F+S++I +NL+P W E ++ +H + L I++FD D +DD
Sbjct: 280 GTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEE-KACILVDHLREPLYIKVFDYDFGLQDD 338
Query: 440 FLGSLMIDLIEVEKERLLDEWFTLDE 465
F+GS +DL ++E R D TL +
Sbjct: 339 FMGSAFLDLTQLELNRPTDVTLTLKD 364
Score = 38.5 bits (88), Expect = 0.028
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 7/91 (7%)
Query: 524 KKISSN--PNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDE-- 579
K + SN +P V+ +GH+ +SKI KT P W E F F ++ + +++ D+
Sbjct: 483 KAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDA 542
Query: 580 -QHQCSLGNLKVPLSQLLTSEDMTVSQRFQL 609
+ +G +V LS L S + T QL
Sbjct: 543 GKRDDFIGRCQVDLSAL--SREQTHKLELQL 571
Score = 31.2 bits (69), Expect = 4.5
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 783 RNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
R+L A +G SDPYV+ L K +S + KTLNP + + FDF
Sbjct: 480 RDLKAMDSNGLSDPYVKFRLGHQKYKS-----KIMPKTLNPQWREQFDF 523
>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 78.2 bits (191), Expect = 3e-14
Identities = 84/316 (26%), Positives = 128/316 (40%), Gaps = 84/316 (26%)
Query: 551 TNEPVWEENFTFFIHNPKRQDLEVE------------------VRDEQHQCSLGNLKVPL 592
T PVWEE T+ H RQD E + V+ + SLG L+VPL
Sbjct: 145 TRVPVWEETLTY--HGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPL 202
Query: 593 SQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKE 652
+L+ PN I L EKR KRP
Sbjct: 203 RKLV-----------------PNRARSFDICL-----EKRRL---------AKRPKSLDT 231
Query: 653 GRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSL 712
S+ + G+P PGG+ + S + A+P P +
Sbjct: 232 ACGMSLYEVVPGAPPPGGATSCCSCRL------------AKPKWLKP-----------TK 268
Query: 713 LASPGHISVKEPTPSIASDISLPIATQELRQRLRQLEN-GTTLGQSPLGQIQLTIRHSSQ 771
+A GH + ++P +P A R +E T + G + L++ +SSQ
Sbjct: 269 VAWTGHFTQRQPR--------VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQ 320
Query: 772 RNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
+ L+V V C +L +G SDP+VR++L P+ + + KT V +KTLNP F++ F +
Sbjct: 321 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 380
Query: 831 SVSLPEVQRRTLDVAV 846
S E+ ++TL V+V
Sbjct: 381 SGPREELAQKTLLVSV 396
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/80 (22%), Positives = 39/80 (48%)
Query: 751 GTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGR 810
G + + LG ++ T+ + + L H + L + +D YV+ LLP ++ +
Sbjct: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQ 136
Query: 811 RKTHVSKKTLNPVFDQSFDF 830
+TH + T PV++++ +
Sbjct: 137 LRTHTVRGTRVPVWEETLTY 156
>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 78.2 bits (191), Expect = 3e-14
Identities = 84/316 (26%), Positives = 128/316 (40%), Gaps = 84/316 (26%)
Query: 551 TNEPVWEENFTFFIHNPKRQDLEVE------------------VRDEQHQCSLGNLKVPL 592
T PVWEE T+ H RQD E + V+ + SLG L+VPL
Sbjct: 145 TRVPVWEETLTY--HGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPL 202
Query: 593 SQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKE 652
+L+ PN I L EKR KRP
Sbjct: 203 RKLV-----------------PNRARSFDICL-----EKRRL---------AKRPKSLDT 231
Query: 653 GRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSL 712
S+ + G+P PGG+ + S + A+P P +
Sbjct: 232 ACGMSLYEVVPGAPPPGGATSCCSCRL------------AKPKWLKP-----------TK 268
Query: 713 LASPGHISVKEPTPSIASDISLPIATQELRQRLRQLEN-GTTLGQSPLGQIQLTIRHSSQ 771
+A GH + ++P +P A R +E T + G + L++ +SSQ
Sbjct: 269 VAWTGHFTQRQPR--------VPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQ 320
Query: 772 RNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
+ L+V V C +L +G SDP+VR++L P+ + + KT V +KTLNP F++ F +
Sbjct: 321 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 380
Query: 831 SVSLPEVQRRTLDVAV 846
S E+ ++TL V+V
Sbjct: 381 SGPREELAQKTLLVSV 396
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/80 (22%), Positives = 39/80 (48%)
Query: 751 GTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGR 810
G + + LG ++ T+ + + L H + L + +D YV+ LLP ++ +
Sbjct: 77 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANLLPGASKASQ 136
Query: 811 RKTHVSKKTLNPVFDQSFDF 830
+TH + T PV++++ +
Sbjct: 137 LRTHTVRGTRVPVWEETLTY 156
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 77.4 bits (189), Expect = 5e-14
Identities = 58/174 (33%), Positives = 90/174 (51%), Gaps = 19/174 (10%)
Query: 728 IASDISLPIATQELRQRLRQLENGTTLGQSPL---GQIQLTIRHSSQRNKLIVVVHACRN 784
+AS S+ A + + L++LE GQ L G+I L++ +SS+R L+V + C +
Sbjct: 219 LASPSSMSAALRGISCYLKELEQAEQ-GQGLLEERGRILLSLSYSSRRRGLLVGILRCAH 277
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L A +G SDPYV+ YL PD + + KT V KKTLNP F++ F + + L + +TL+
Sbjct: 278 LAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLE 337
Query: 844 VAVKNSGGFLSKDKGLLGKV-LVALASEELAKGWT-----------QWYDLTED 885
V V + + K +G V L A E K W+ +W+ LT +
Sbjct: 338 VTVWDYD--IGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSE 389
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/55 (32%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 793 SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFS-VSLPEVQRRTLDVAV 846
+DPYV+++LLP ++ + KT + TLNPV+++ +S ++ ++ + L +AV
Sbjct: 125 ADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAV 179
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 75.9 bits (185), Expect = 2e-13
Identities = 45/125 (36%), Positives = 73/125 (58%), Gaps = 5/125 (4%)
Query: 759 LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSK 817
LG++Q ++ + Q N+L V V L A G SDPYV+++LLPDK++ K H +
Sbjct: 140 LGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVH--R 197
Query: 818 KTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWT 877
KTLNP F+++F F V E+ +TL +A+ + F D ++G+V V + + +L +
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHD--IIGEVKVPMNTVDLGQPIE 255
Query: 878 QWYDL 882
+W DL
Sbjct: 256 EWRDL 260
Score = 74.7 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 8/168 (4%)
Query: 728 IASDISLPIATQELRQRL---RQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 784
I ++ +P+ T +L Q + R L+ G LG I ++R+ KL V + +N
Sbjct: 237 IIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKN 296
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L G SDPYV+++L+ + +R ++KT V KKTLNP F++SF F + ++Q+ +
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVV 356
Query: 844 VAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
V V + L K++ +GK+ V S W D+ + RP A
Sbjct: 357 VTVLDYDK-LGKNEA-IGKIFV--GSNATGTELRHWSDMLANPRRPIA 400
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 75.9 bits (185), Expect = 2e-13
Identities = 45/125 (36%), Positives = 73/125 (58%), Gaps = 5/125 (4%)
Query: 759 LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSK 817
LG++Q ++ + Q N+L V V L A G SDPYV+++LLPDK++ K H +
Sbjct: 140 LGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVH--R 197
Query: 818 KTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWT 877
KTLNP F+++F F V E+ +TL +A+ + F D ++G+V V + + +L +
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHD--IIGEVKVPMNTVDLGQPIE 255
Query: 878 QWYDL 882
+W DL
Sbjct: 256 EWRDL 260
Score = 74.7 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 8/168 (4%)
Query: 728 IASDISLPIATQELRQRL---RQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 784
I ++ +P+ T +L Q + R L+ G LG I ++R+ KL V + +N
Sbjct: 237 IIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKN 296
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L G SDPYV+++L+ + +R ++KT V KKTLNP F++SF F + ++Q+ +
Sbjct: 297 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVV 356
Query: 844 VAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
V V + L K++ +GK+ V S W D+ + RP A
Sbjct: 357 VTVLDYDK-LGKNEA-IGKIFV--GSNATGTELRHWSDMLANPRRPIA 400
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 75.9 bits (185), Expect = 2e-13
Identities = 48/134 (35%), Positives = 78/134 (58%), Gaps = 7/134 (5%)
Query: 757 SPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHV 815
+P G+I +R+ ++L+V + +L A +G SDPYV++YLLPD+++ + K H
Sbjct: 298 APCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH- 356
Query: 816 SKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLV--ALASEELA 873
+KTLNPVF+++F FSV L E+ +R L +V + F D L+G+V++ L E
Sbjct: 357 -RKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHD--LIGQVVLDNLLELAEQP 413
Query: 874 KGWTQWYDLTEDGT 887
W D+ E G+
Sbjct: 414 PDRPLWRDIVEGGS 427
Score = 55.1 bits (131), Expect = 3e-07
Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
++ LG++ ++ + +L V + NL A G SDPYV+ L+ + RR +RKT
Sbjct: 429 KADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTS 488
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
+ K TLNP ++++ F V+ V+ L +AV
Sbjct: 489 IKKNTLNPTYNEALVFDVAPESVENVGLSIAV 520
Score = 38.5 bits (88), Expect = 0.028
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 39/246 (15%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENL 406
LR+ L + ++A DL KD+ G SDPY I + + FQ++V ++ L
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTL 360
Query: 407 SPKWNEVYEALV--YEHPGQELEIELFDEDP-DKDDFLGSLMIDLIEVEKERLLDEWFTL 463
+P +NE ++ V E ++L ++D D + D +G +++D + E+ D
Sbjct: 361 NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR 420
Query: 464 DEVPKGKLHLRLEWLTL----MPNASNLDKVLTDIKADKDQAND--GLSSALLILYLDSA 517
D V G L L +P A L +T IKA +A D G S + A
Sbjct: 421 DIVEGGSEKADLGELNFSLCYLPTAGRL--TVTIIKASNLKAMDLTGFSDPYV-----KA 473
Query: 518 RNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVR 577
+ G+++ K +++ I+ T P + E F + +++ + +
Sbjct: 474 SLISEGRRL--------------KKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIA 519
Query: 578 DEQHQC 583
+ C
Sbjct: 520 VVDYDC 525
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 75.9 bits (185), Expect = 2e-13
Identities = 48/134 (35%), Positives = 78/134 (58%), Gaps = 7/134 (5%)
Query: 757 SPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHV 815
+P G+I +R+ ++L+V + +L A +G SDPYV++YLLPD+++ + K H
Sbjct: 298 APCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH- 356
Query: 816 SKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLV--ALASEELA 873
+KTLNPVF+++F FSV L E+ +R L +V + F D L+G+V++ L E
Sbjct: 357 -RKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHD--LIGQVVLDNLLELAEQP 413
Query: 874 KGWTQWYDLTEDGT 887
W D+ E G+
Sbjct: 414 PDRPLWRDIVEGGS 427
Score = 55.1 bits (131), Expect = 3e-07
Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
++ LG++ ++ + +L V + NL A G SDPYV+ L+ + RR +RKT
Sbjct: 429 KADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTS 488
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
+ K TLNP ++++ F V+ V+ L +AV
Sbjct: 489 IKKNTLNPTYNEALVFDVAPESVENVGLSIAV 520
Score = 38.5 bits (88), Expect = 0.028
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 39/246 (15%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENL 406
LR+ L + ++A DL KD+ G SDPY I + + FQ++V ++ L
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTL 360
Query: 407 SPKWNEVYEALV--YEHPGQELEIELFDEDP-DKDDFLGSLMIDLIEVEKERLLDEWFTL 463
+P +NE ++ V E ++L ++D D + D +G +++D + E+ D
Sbjct: 361 NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR 420
Query: 464 DEVPKGKLHLRLEWLTL----MPNASNLDKVLTDIKADKDQAND--GLSSALLILYLDSA 517
D V G L L +P A L +T IKA +A D G S + A
Sbjct: 421 DIVEGGSEKADLGELNFSLCYLPTAGRL--TVTIIKASNLKAMDLTGFSDPYV-----KA 473
Query: 518 RNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVR 577
+ G+++ K +++ I+ T P + E F + +++ + +
Sbjct: 474 SLISEGRRL--------------KKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIA 519
Query: 578 DEQHQC 583
+ C
Sbjct: 520 VVDYDC 525
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 75.9 bits (185), Expect = 2e-13
Identities = 48/134 (35%), Positives = 78/134 (58%), Gaps = 7/134 (5%)
Query: 757 SPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHV 815
+P G+I +R+ ++L+V + +L A +G SDPYV++YLLPD+++ + K H
Sbjct: 298 APCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH- 356
Query: 816 SKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLV--ALASEELA 873
+KTLNPVF+++F FSV L E+ +R L +V + F D L+G+V++ L E
Sbjct: 357 -RKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHD--LIGQVVLDNLLELAEQP 413
Query: 874 KGWTQWYDLTEDGT 887
W D+ E G+
Sbjct: 414 PDRPLWRDIVEGGS 427
Score = 55.1 bits (131), Expect = 3e-07
Identities = 30/92 (32%), Positives = 51/92 (55%), Gaps = 1/92 (1%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
++ LG++ ++ + +L V + NL A G SDPYV+ L+ + RR +RKT
Sbjct: 429 KADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTS 488
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
+ K TLNP ++++ F V+ V+ L +AV
Sbjct: 489 IKKNTLNPTYNEALVFDVAPESVENVGLSIAV 520
Score = 38.5 bits (88), Expect = 0.028
Identities = 56/246 (22%), Positives = 102/246 (41%), Gaps = 39/246 (15%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENL 406
LR+ L + ++A DL KD+ G SDPY I + + FQ++V ++ L
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS------NGFSDPYVKIYLLPDRKKKFQTKVHRKTL 360
Query: 407 SPKWNEVYEALV--YEHPGQELEIELFDEDP-DKDDFLGSLMIDLIEVEKERLLDEWFTL 463
+P +NE ++ V E ++L ++D D + D +G +++D + E+ D
Sbjct: 361 NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR 420
Query: 464 DEVPKGKLHLRLEWLTL----MPNASNLDKVLTDIKADKDQAND--GLSSALLILYLDSA 517
D V G L L +P A L +T IKA +A D G S + A
Sbjct: 421 DIVEGGSEKADLGELNFSLCYLPTAGRL--TVTIIKASNLKAMDLTGFSDPYV-----KA 473
Query: 518 RNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVR 577
+ G+++ K +++ I+ T P + E F + +++ + +
Sbjct: 474 SLISEGRRL--------------KKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIA 519
Query: 578 DEQHQC 583
+ C
Sbjct: 520 VVDYDC 525
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 75.1 bits (183), Expect = 3e-13
Identities = 44/139 (31%), Positives = 77/139 (55%), Gaps = 15/139 (10%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKK 818
G+I +++++SSQ+ L+V + C +L A +G SDPYV+ YL PD + + KT V KK
Sbjct: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKK 327
Query: 819 TLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVAL-ASEELAKGW- 876
TLNP F++ F + + ++ +++L+V V + + K +G V++ + A E K W
Sbjct: 328 TLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYD--IGKSNDFIGGVVLGIHAKGERLKHWF 385
Query: 877 ----------TQWYDLTED 885
+W+ LT +
Sbjct: 386 DCLKNKDKRIERWHTLTSE 404
Score = 48.1 bits (113), Expect = 4e-05
Identities = 51/232 (21%), Positives = 97/232 (41%), Gaps = 38/232 (16%)
Query: 648 SVSKEGRKT--SIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQG---- 701
++ + G K SI+ HM+ PG P P+ SD + PP+AGP+
Sbjct: 2 TLRRRGEKATISIQEHMAIDVCPG-----PIRPIKQISDYFPRFPRGLPPDAGPRAAAPP 56
Query: 702 -------LHDLGRSSSS------------LLASPGHISVKEPTPSIASDISLPIATQELR 742
+ GR S S L + G P PS A + P +
Sbjct: 57 DAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEP-- 114
Query: 743 QRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYL 801
+ + + LG + ++ + + N L + + L +G +DPYV+++L
Sbjct: 115 ----DADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHL 170
Query: 802 LPDKRRSGRRKTHVSKKTLNPVFDQSFD-FSVSLPEVQRRTLDVAVKNSGGF 852
LP ++ + +T + TLNP ++++ + ++ ++ R+TL ++V + F
Sbjct: 171 LPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF 222
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 74.3 bits (181), Expect = 5e-13
Identities = 44/128 (34%), Positives = 72/128 (56%), Gaps = 5/128 (3%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
+ LG++Q ++ + Q N+L+V + L A G SDPYV+++LLPDK++ K H
Sbjct: 140 EEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVH 199
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAK 874
+KTLNPVF++ F F V E+ +TL +AV + F D ++G+ V + + +
Sbjct: 200 --RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHD--IIGEFKVPMNTVDFGH 255
Query: 875 GWTQWYDL 882
+W DL
Sbjct: 256 VTEEWRDL 263
Score = 70.5 bits (171), Expect = 7e-12
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 8/168 (4%)
Query: 728 IASDISLPIATQE---LRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 784
I + +P+ T + + + R L++ Q LG I ++R+ KL VV+ +N
Sbjct: 240 IIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKN 299
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L G SDPYV+++L+ + +R ++KT + K TLNP +++SF F V ++Q+ +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVV 359
Query: 844 VAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
V V + D +GKV V S W D+ + RP A
Sbjct: 360 VTVLDYDKIGKND--AIGKVFVGYNS--TGAELRHWSDMLANPRRPIA 403
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 74.3 bits (181), Expect = 5e-13
Identities = 44/128 (34%), Positives = 72/128 (56%), Gaps = 5/128 (3%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
+ LG++Q ++ + Q N+L+V + L A G SDPYV+++LLPDK++ K H
Sbjct: 140 EEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVH 199
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAK 874
+KTLNPVF++ F F V E+ +TL +AV + F D ++G+ V + + +
Sbjct: 200 --RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHD--IIGEFKVPMNTVDFGH 255
Query: 875 GWTQWYDL 882
+W DL
Sbjct: 256 VTEEWRDL 263
Score = 70.5 bits (171), Expect = 7e-12
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 8/168 (4%)
Query: 728 IASDISLPIATQE---LRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 784
I + +P+ T + + + R L++ Q LG I ++R+ KL VV+ +N
Sbjct: 240 IIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKN 299
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L G SDPYV+++L+ + +R ++KT + K TLNP +++SF F V ++Q+ +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVV 359
Query: 844 VAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
V V + D +GKV V S W D+ + RP A
Sbjct: 360 VTVLDYDKIGKND--AIGKVFVGYNS--TGAELRHWSDMLANPRRPIA 403
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 74.3 bits (181), Expect = 5e-13
Identities = 44/128 (34%), Positives = 72/128 (56%), Gaps = 5/128 (3%)
Query: 756 QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTH 814
+ LG++Q ++ + Q N+L+V + L A G SDPYV+++LLPDK++ K H
Sbjct: 140 EEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVH 199
Query: 815 VSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAK 874
+KTLNPVF++ F F V E+ +TL +AV + F D ++G+ V + + +
Sbjct: 200 --RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHD--IIGEFKVPMNTVDFGH 255
Query: 875 GWTQWYDL 882
+W DL
Sbjct: 256 VTEEWRDL 263
Score = 70.5 bits (171), Expect = 7e-12
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 8/168 (4%)
Query: 728 IASDISLPIATQE---LRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRN 784
I + +P+ T + + + R L++ Q LG I ++R+ KL VV+ +N
Sbjct: 240 IIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKN 299
Query: 785 LIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLD 843
L G SDPYV+++L+ + +R ++KT + K TLNP +++SF F V ++Q+ +
Sbjct: 300 LKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVV 359
Query: 844 VAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
V V + D +GKV V S W D+ + RP A
Sbjct: 360 VTVLDYDKIGKND--AIGKVFVGYNS--TGAELRHWSDMLANPRRPIA 403
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 74.3 bits (181), Expect = 5e-13
Identities = 48/125 (38%), Positives = 72/125 (57%), Gaps = 5/125 (4%)
Query: 759 LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGS-DPYVRMYLLPDKRRSGRRKTHVSK 817
LG++Q ++ + Q +L+V + L A GS DPYVR+YLLPDKRR R +T V +
Sbjct: 109 LGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRR--RYETKVHR 166
Query: 818 KTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWT 877
+TLNP F ++F F V E+ R L +AV + F D +G+V V ++S +L +
Sbjct: 167 QTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRND--AIGEVRVPMSSVDLGRPVQ 224
Query: 878 QWYDL 882
W +L
Sbjct: 225 AWREL 229
Score = 71.2 bits (173), Expect = 4e-12
Identities = 49/165 (29%), Positives = 88/165 (53%), Gaps = 8/165 (4%)
Query: 731 DISLPIATQELR---QRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIA 787
++ +P+++ +L Q R+L+ Q LG I ++R+ KL V+V +NL
Sbjct: 209 EVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKK 268
Query: 788 FSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
G SDPYV+++LL ++ ++KT + K TLNP ++++F F V +VQ+ +++ V
Sbjct: 269 MDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTV 328
Query: 847 KNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA 891
+ L K++ +G+V V A+ G W D+ + RP A
Sbjct: 329 LDYDK-LGKNEA-IGRVAVGAAAG--GAGLRHWADMLANPRRPIA 369
Score = 47.4 bits (111), Expect = 6e-05
Identities = 55/238 (23%), Positives = 104/238 (43%), Gaps = 38/238 (15%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-----GNQIFQSRVIKE 404
L + G L + ++A L D + G SDPY +RV + ++++V ++
Sbjct: 116 LDYDFQSGQLLVGILQAMGLAALD------LGGSSDPY--VRVYLLPDKRRRYETKVHRQ 167
Query: 405 NLSPKWNEVYEALV--YEHPGQELEIELFDEDP-DKDDFLGSLMIDLIEVEKERLLDEWF 461
L+P + E + V E G+ L + ++D D ++D +G + + + V+ R + W
Sbjct: 168 TLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWR 227
Query: 462 TLDEVPKG---KLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSAR 518
L P+ KL L +P A L ++ + K K GLS + ++L
Sbjct: 228 ELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHL---- 283
Query: 519 NLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEV 576
L GKK+ + +++ I+ T P + E F+F + + Q ++VE+
Sbjct: 284 -LQGGKKV--------------RKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVEL 326
Score = 33.1 bits (74), Expect = 1.2
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 11/93 (11%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPY---GIIRVGNQIFQSRV-IKEN 405
LR+ G L + +EA++L+ D V G SDPY +++ G ++ + + IK+N
Sbjct: 247 LRYVPTAGKLTVIVLEAKNLKKMD------VGGLSDPYVKVHLLQGGKKVRKKKTTIKKN 300
Query: 406 -LSPKWNEVYEALVYEHPGQELEIELFDEDPDK 437
L+P +NE + V Q++++EL D DK
Sbjct: 301 TLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDK 333
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/126 (35%), Positives = 79/126 (62%), Gaps = 8/126 (6%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDP--YVRMYLLPDKRRSGRRKTHVSK 817
G+++L+I S + NKL ++V R L +DG+DP YV++YLLPD +++ +RKT V++
Sbjct: 1506 GEVKLSI--SYKNNKLFIMVMHIRGL-QLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVAR 1562
Query: 818 KTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGW 876
KT NP +++ + + ++Q+R L ++V + GF + LLG+V + L +LA+
Sbjct: 1563 KTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVNIRLRELDLAQEK 1620
Query: 877 TQWYDL 882
T W+ L
Sbjct: 1621 TGWFAL 1626
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 71.6 bits (174), Expect = 3e-12
Identities = 44/125 (35%), Positives = 69/125 (55%), Gaps = 5/125 (4%)
Query: 742 RQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMY 800
+QR ++G G++ +++ +LIV +H NL A G SDPYV++Y
Sbjct: 204 KQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIY 263
Query: 801 LLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLL 860
LLPD++ + K H +KTLNPVFD+ F F V +++ R L +V + F D L+
Sbjct: 264 LLPDRKTKHQTKVH--RKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHD--LI 319
Query: 861 GKVLV 865
G+V+V
Sbjct: 320 GQVVV 324
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
Query: 759 LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSK 817
LG++ ++ + +L + + RNL A G SDPYV++ L+ D RR +RKT +
Sbjct: 353 LGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKR 412
Query: 818 KTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
TLNPV++++ F V + + L +AV
Sbjct: 413 NTLNPVYNEAIVFDVPPENIDQIHLSIAV 441
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.9 bits (172), Expect = 5e-12
Identities = 34/96 (35%), Positives = 60/96 (62%), Gaps = 4/96 (4%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG---SDPYVRMYLLPDKRRSGRRKTHVS 816
G+I ++++ Q L+V V C L A++++ S+PYV+ YLLPDK R G+RKT +
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQL-AYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIK 416
Query: 817 KKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGF 852
+ T+NP++D++ + + + +RTL +V + G F
Sbjct: 417 RDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRF 452
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 16/169 (9%)
Query: 717 GHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLI 776
G IS + PT LP EL L+ + T P+G + + + +L
Sbjct: 482 GKISAESPT-------GLPSHKGELVVSLKYIPASKT----PVGGDRKKSK-GGEGGELQ 529
Query: 777 VVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFS-VSL 834
V + +NL A G SD +V+ YLLP + ++ +RKT V KKTLNP ++ +F ++ V L
Sbjct: 530 VWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRL 589
Query: 835 PEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLT 883
++Q L++ V + S D LG V + + + W D T
Sbjct: 590 EDLQHMCLELTVWDREPLASND--FLGGVRLGVGTGISNGEVVDWMDST 636
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.9 bits (172), Expect = 5e-12
Identities = 34/96 (35%), Positives = 60/96 (62%), Gaps = 4/96 (4%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG---SDPYVRMYLLPDKRRSGRRKTHVS 816
G+I ++++ Q L+V V C L A++++ S+PYV+ YLLPDK R G+RKT +
Sbjct: 358 GRIAFSLKYEQQTQSLVVHVKECHQL-AYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIK 416
Query: 817 KKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGF 852
+ T+NP++D++ + + + +RTL +V + G F
Sbjct: 417 RDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRF 452
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 16/169 (9%)
Query: 717 GHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLI 776
G IS + PT LP EL L+ + T P+G + + + +L
Sbjct: 482 GKISAESPT-------GLPSHKGELVVSLKYIPASKT----PVGGDRKKSK-GGEGGELQ 529
Query: 777 VVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFS-VSL 834
V + +NL A G SD +V+ YLLP + ++ +RKT V KKTLNP ++ +F ++ V L
Sbjct: 530 VWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRL 589
Query: 835 PEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLT 883
++Q L++ V + S D LG V + + + W D T
Sbjct: 590 EDLQHMCLELTVWDREPLASND--FLGGVRLGVGTGISNGEVVDWMDST 636
>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
Length = 542
Score = 70.5 bits (171), Expect = 7e-12
Identities = 41/129 (31%), Positives = 73/129 (56%), Gaps = 9/129 (6%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGS---DPYVRMYLLPDKRRSGRRKTHVS 816
G+I+ I + + + L + + AC+NL A+ E+ +PYV+ YLLPD+ G+RKT V
Sbjct: 240 GEIEFAIHYCFKTHSLEICIKACKNL-AYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQ 298
Query: 817 KKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGW 876
+ T++P F ++ + V+ ++ R L V+V + G + LG+V++ LA+ +
Sbjct: 299 RNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLAR--RVFLGEVIIPLATWDFEDST 356
Query: 877 TQ---WYDL 882
TQ W+ L
Sbjct: 357 TQSFRWHPL 365
>gi|216548478 synaptotagmin XI [Homo sapiens]
Length = 431
Score = 70.1 bits (170), Expect = 9e-12
Identities = 62/180 (34%), Positives = 92/180 (51%), Gaps = 23/180 (12%)
Query: 722 KEPT-PSIASDIS-LPIAT---QELRQRLRQL---ENGTTLGQSP-----LGQIQLTIRH 768
K+P PS S I LPI +ELR + L E+ TT SP LG + ++ +
Sbjct: 108 KDPRGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEEDVMLGSLTFSVDY 167
Query: 769 SSQRNKLIVVVHACRNLIAFSED--GSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQ 826
+ + L+V + L + GSDPY++M +LPDKR R KT V +KTL+PVFD+
Sbjct: 168 NFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRH--RVKTRVLRKTLDPVFDE 225
Query: 827 SFDF-SVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTED 885
+F F + ++Q L V + F D ++G+V+V LA + + G Q LT D
Sbjct: 226 TFTFYGIPYSQLQDLVLHFLVLSFDRFSRDD--VIGEVMVPLAGVDPSTGKVQ---LTRD 280
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 19/141 (13%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG--SDPYVRMYLLPDKRRSGRRKTHVSK 817
G++Q+++ + ++ VVV R+L G +PYV++ + ++R ++KTHV K
Sbjct: 293 GELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKK 352
Query: 818 KTLNPVFDQSFDFSVS---LPEVQRRTL----DVAVKNSGGFLSKDKGLLGKVLVALASE 870
TLNP+F++SF + + LP++ L D KN ++G++++ A
Sbjct: 353 CTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNE---------VVGRLILG-AHS 402
Query: 871 ELAKGWTQWYDLTEDGTRPQA 891
A G W ++ E +P A
Sbjct: 403 VTASGAEHWREVCESPRKPVA 423
Score = 30.4 bits (67), Expect = 7.7
Identities = 20/68 (29%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 510 LILYLDSARNLPSGKKISSNPNPVVQMSV----GHKAQESKIRYKTNEPVWEENFTFF-I 564
L++ + A LP + +P ++M++ H+ + +R KT +PV++E FTF+ I
Sbjct: 174 LVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLR-KTLDPVFDETFTFYGI 232
Query: 565 HNPKRQDL 572
+ QDL
Sbjct: 233 PYSQLQDL 240
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 69.3 bits (168), Expect = 1e-11
Identities = 60/216 (27%), Positives = 107/216 (49%), Gaps = 22/216 (10%)
Query: 686 PGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLP-----IATQE 740
PG++ K E L SS++ H+ PT + +S + P + +
Sbjct: 4617 PGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVH-SGPTSAGSSSVPSPGQPGSPSVSK 4675
Query: 741 LRQRLRQLENGTTLGQSPL-GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVR 798
+ + +GT + P+ G+IQL I + LI+ + RNL+ +G SDP+V+
Sbjct: 4676 KKHGSSKPTDGTKVVSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSDPFVK 4733
Query: 799 MYLLPDKRR---------SGRRKTHVSKKTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKN 848
+YLLP + + +R+T +K+LNP ++Q+ + S+S+ +++++TL+V V +
Sbjct: 4734 VYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWD 4793
Query: 849 SGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTE 884
F S D LG+VL+ L+S +WY L E
Sbjct: 4794 YDRFSSND--FLGEVLIDLSSTSHLDNTPRWYPLKE 4827
Score = 45.8 bits (107), Expect = 2e-04
Identities = 39/158 (24%), Positives = 80/158 (50%), Gaps = 31/158 (19%)
Query: 337 ITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYG-------- 388
++ P+ E+Q+ Q+ + + G L IH ++A++L +D G SDP+
Sbjct: 4690 VSHPITGEIQL-QINYDL--GNLIIHILQARNLVPRDN------NGYSDPFVKVYLLPGR 4740
Query: 389 ----IIRVGNQIFQSRV--IKENLSPKWNE--VYEALVYEHPGQE-LEIELFDEDP-DKD 438
+++ + ++ R ++++L+P+WN+ +Y+++ E ++ LE+ ++D D +
Sbjct: 4741 GQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSN 4800
Query: 439 DFLGSLMIDLIEVEKERLLDEWFTLDE----VPKGKLH 472
DFLG ++IDL W+ L E + GK H
Sbjct: 4801 DFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSH 4838
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 69.3 bits (168), Expect = 1e-11
Identities = 60/216 (27%), Positives = 107/216 (49%), Gaps = 22/216 (10%)
Query: 686 PGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLP-----IATQE 740
PG++ K E L SS++ H+ PT + +S + P + +
Sbjct: 4617 PGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVH-SGPTSAGSSSVPSPGQPGSPSVSK 4675
Query: 741 LRQRLRQLENGTTLGQSPL-GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVR 798
+ + +GT + P+ G+IQL I + LI+ + RNL+ +G SDP+V+
Sbjct: 4676 KKHGSSKPTDGTKVVSHPITGEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSDPFVK 4733
Query: 799 MYLLPDKRR---------SGRRKTHVSKKTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKN 848
+YLLP + + +R+T +K+LNP ++Q+ + S+S+ +++++TL+V V +
Sbjct: 4734 VYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWD 4793
Query: 849 SGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTE 884
F S D LG+VL+ L+S +WY L E
Sbjct: 4794 YDRFSSND--FLGEVLIDLSSTSHLDNTPRWYPLKE 4827
Score = 48.5 bits (114), Expect = 3e-05
Identities = 99/440 (22%), Positives = 179/440 (40%), Gaps = 76/440 (17%)
Query: 502 NDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFT 561
N+G S + +YL LP ++ VVQ + + +K K+ P W +
Sbjct: 4724 NNGYSDPFVKVYL-----LPGRGQVM-----VVQNASAEYKRRTKHVQKSLNPEWNQTVI 4773
Query: 562 F---FIHNPKRQDLEVEVRDEQHQCS---LGNLKV---------------PLSQLLTSED 600
+ + K++ LEV V D S LG + + PL + S D
Sbjct: 4774 YKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESID 4833
Query: 601 MTVSQRFQLSNSGPN-STIKMKIA---------LRVLHLEKRERPPDHQHSAQ---VKRP 647
S Q S P S IK + ++V +EK P S+ ++
Sbjct: 4834 HGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSH 4893
Query: 648 SVSKEGRKTSI-KSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLG 706
S+ KTS+ ++H+ + G + A V +P +P E+ G
Sbjct: 4894 GPSRSQSKTSVTQTHLEDA---GAAIAAAEAAVQQLRIQPTKPPNHRPAESSVS----TG 4946
Query: 707 RSSSSLLASPGHISVKEPTPSIASDISL-PIAT-----QELRQRLRQLENGTTLGQSP-- 758
S SS G+ E + S A + +L PI Q ++ ++Q G L +
Sbjct: 4947 SSGSSF--GSGYSVDSEGSSSTAGETNLFPIPRIGKMGQNGQEPVKQPGVGVGLADTEAK 5004
Query: 759 ---LGQIQLTIRHSSQRN--KLIVVVHACRNL---IAFSEDGSDPYVRMYLL--PDKRRS 808
+G+I++ ++ + + +LIV + CRN+ + D YV++Y++ +++
Sbjct: 5005 TQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKV 5064
Query: 809 GRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALA 868
++KT V + P F+++F FS+S +L + + ++GG K K L+G+ + L
Sbjct: 5065 IKKKTRVCRHDREPSFNETFRFSLS---PAGHSLQILLFSNGGKFMK-KTLIGEACIWLD 5120
Query: 869 SEELAKGWTQWYDLTEDGTR 888
+L K W+ L T+
Sbjct: 5121 KVDLRKRIVNWHKLLVSPTQ 5140
Score = 45.8 bits (107), Expect = 2e-04
Identities = 39/158 (24%), Positives = 80/158 (50%), Gaps = 31/158 (19%)
Query: 337 ITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYG-------- 388
++ P+ E+Q+ Q+ + + G L IH ++A++L +D G SDP+
Sbjct: 4690 VSHPITGEIQL-QINYDL--GNLIIHILQARNLVPRDN------NGYSDPFVKVYLLPGR 4740
Query: 389 ----IIRVGNQIFQSRV--IKENLSPKWNE--VYEALVYEHPGQE-LEIELFDEDP-DKD 438
+++ + ++ R ++++L+P+WN+ +Y+++ E ++ LE+ ++D D +
Sbjct: 4741 GQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSN 4800
Query: 439 DFLGSLMIDLIEVEKERLLDEWFTLDE----VPKGKLH 472
DFLG ++IDL W+ L E + GK H
Sbjct: 4801 DFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSH 4838
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 69.3 bits (168), Expect = 1e-11
Identities = 42/126 (33%), Positives = 75/126 (59%), Gaps = 7/126 (5%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKK 818
G++ T+++ + L+V + +L A G SDPYV+MYLLPD+++ + +T V +K
Sbjct: 233 GKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKK--KFQTRVHRK 290
Query: 819 TLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASE--ELAKGW 876
TLNP+FD++F F V+ ++ R L +V + F D ++G+V++ E +L++
Sbjct: 291 TLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHD--MIGEVILDNLFEVSDLSREA 348
Query: 877 TQWYDL 882
T W D+
Sbjct: 349 TVWKDI 354
Score = 59.3 bits (142), Expect = 2e-08
Identities = 32/89 (35%), Positives = 52/89 (58%), Gaps = 1/89 (1%)
Query: 759 LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGS-DPYVRMYLLPDKRRSGRRKTHVSK 817
LG+I ++ + ++ + V CRNL A GS DPYV++ L+ + RR +RKT K
Sbjct: 364 LGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKK 423
Query: 818 KTLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
TLNPV++++ F + V + +L +AV
Sbjct: 424 NTLNPVYNEAIIFDIPPENVDQVSLSIAV 452
Score = 38.9 bits (89), Expect = 0.022
Identities = 61/249 (24%), Positives = 108/249 (43%), Gaps = 53/249 (21%)
Query: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYG---IIRVGNQIFQSRVIKENL 406
L++ +L + I+A DL KD G SDPY ++ + FQ+RV ++ L
Sbjct: 239 LQYDYENELLVVKIIKALDLPAKD------FTGTSDPYVKMYLLPDRKKKFQTRVHRKTL 292
Query: 407 SPKWNEVYE-ALVYEH-PGQELEIELFDEDP-DKDDFLGSLMID-LIEV-EKERLLDEW- 460
+P ++E ++ + Y+ ++L ++D D + D +G +++D L EV + R W
Sbjct: 293 NPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWK 352
Query: 461 ----FTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDS 516
T + + G++ L +L P A + LT IK +A D
Sbjct: 353 DIHCATTESIDLGEIMFSLCYL---PTAGRM--TLTVIKCRNLKAMD------------- 394
Query: 517 ARNLPSGKKISSNPNPVVQMSV---GHKAQESKIRYKTN--EPVWEENFTFFI--HNPKR 569
I+ + +P V++S+ G + ++ K K N PV+ E F I N +
Sbjct: 395 ---------ITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQ 445
Query: 570 QDLEVEVRD 578
L + V D
Sbjct: 446 VSLSIAVMD 454
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 68.9 bits (167), Expect = 2e-11
Identities = 31/88 (35%), Positives = 59/88 (67%), Gaps = 1/88 (1%)
Query: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKK 818
G+I +++ +S+Q+ LIV + C +L A +G SDP+V+++L PD + + KT + KK
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 611
Query: 819 TLNPVFDQSFDFSVSLPEVQRRTLDVAV 846
TLNP F++ F + + ++ +++LD++V
Sbjct: 612 TLNPEFNEEFFYDIKHSDLAKKSLDISV 639
Score = 54.7 bits (130), Expect = 4e-07
Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 25/228 (10%)
Query: 640 HSAQVKRPSVSKEGRKTSIKSHMSGSPG-PGGSNTAPST--------PVIGGSDKPGMEE 690
+S Q RP+ G S G PG PGGS P P + SD PG
Sbjct: 271 NSVQASRPA---PGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSD-PGTTA 326
Query: 691 KAQPPEAGPQGLHDLGRSSSSLLASPG----HISVKEPTPSIASDISLPIATQELRQRLR 746
+ G G + + ++ P S P P+ A P +E
Sbjct: 327 PPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYD 386
Query: 747 QLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDK 805
E T LG ++ ++ + + L + + L +G +DPYV+++LLP
Sbjct: 387 SDEATT------LGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGA 440
Query: 806 RRSGRRKTHVSKKTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKNSGGF 852
+S + +T + T NP+++++ + ++ ++QR+TL ++V + F
Sbjct: 441 SKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF 488
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,758,802
Number of Sequences: 37866
Number of extensions: 1860663
Number of successful extensions: 11406
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 262
Number of HSP's that attempted gapping in prelim test: 10058
Number of HSP's gapped (non-prelim): 1487
length of query: 893
length of database: 18,247,518
effective HSP length: 111
effective length of query: 782
effective length of database: 14,044,392
effective search space: 10982714544
effective search space used: 10982714544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.