Search of human proteins with 4507897

Search of human proteins with 4507897

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507897 vasoactive intestinal peptide isoform 1
preproprotein [Homo sapiens]
         (170 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507897 vasoactive intestinal peptide isoform 1 preproprotein...   336   7e-93
gi|37588853 vasoactive intestinal peptide isoform 2 preproprotei...   330   5e-91
gi|153266792 adenylate cyclase activating polypeptide precursor ...    70   7e-13
gi|153266795 adenylate cyclase activating polypeptide precursor ...    70   7e-13
gi|4503945 glucagon preproprotein [Homo sapiens]                       53   1e-07
gi|11034841 growth hormone releasing hormone preproprotein [Homo...    44   9e-05
gi|11345450 secretin preproprotein [Homo sapiens]                      33   0.091
gi|110349721 titin isoform novex-3 [Homo sapiens]                      30   1.3  
gi|148727368 bromodomain and PHD finger containing, 3 [Homo sapi...    29   1.7  
gi|7657269 PDS5, regulator of cohesion maintenance, homolog B [H...    28   3.8  
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   28   3.8  
gi|23308597 adenomatosis polyposis coli down-regulated 1 [Homo s...    28   5.0  
gi|110349786 Alstrom syndrome 1 [Homo sapiens]                         27   6.5  
gi|122891870 melanoma inhibitory activity family, member 3 [Homo...    27   6.5  
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]    27   6.5  
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi...    27   6.5  
gi|157388929 epsin 3 [Homo sapiens]                                    27   6.5  

>gi|4507897 vasoactive intestinal peptide isoform 1 preproprotein
           [Homo sapiens]
          Length = 170

 Score =  336 bits (861), Expect = 7e-93
 Identities = 170/170 (100%), Positives = 170/170 (100%)

Query: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60
           MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
Sbjct: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60

Query: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 120
           LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV
Sbjct: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 120

Query: 121 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 170
           PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
Sbjct: 121 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 170


>gi|37588853 vasoactive intestinal peptide isoform 2 preproprotein
           [Homo sapiens]
          Length = 169

 Score =  330 bits (845), Expect = 5e-91
 Identities = 169/170 (99%), Positives = 169/170 (99%), Gaps = 1/170 (0%)

Query: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60
           MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
Sbjct: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60

Query: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 120
           LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRV SNISEDPV
Sbjct: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRV-SNISEDPV 119

Query: 121 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 170
           PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
Sbjct: 120 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 169


>gi|153266792 adenylate cyclase activating polypeptide precursor
           [Homo sapiens]
          Length = 176

 Score = 70.5 bits (171), Expect = 7e-13
 Identities = 39/79 (49%), Positives = 55/79 (69%), Gaps = 6/79 (7%)

Query: 82  ADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNIS----EDPVPV-KRHSDAVFTDNYTR 136
           A G+    + K+L QLSA K+L+SL+ + V  ++     +D  P+ KRHSD +FTD+Y+R
Sbjct: 84  AHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSR 143

Query: 137 LRKQMAVKKYLNSILNGKR 155
            RKQMAVKKYL ++L GKR
Sbjct: 144 YRKQMAVKKYLAAVL-GKR 161



 Score = 40.8 bits (94), Expect = 6e-04
 Identities = 15/36 (41%), Positives = 25/36 (69%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNI 115
           RH+DG+FT  +S+   Q++ KKYL +++GKR    +
Sbjct: 131 RHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRV 166


>gi|153266795 adenylate cyclase activating polypeptide precursor
           [Homo sapiens]
          Length = 176

 Score = 70.5 bits (171), Expect = 7e-13
 Identities = 39/79 (49%), Positives = 55/79 (69%), Gaps = 6/79 (7%)

Query: 82  ADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNIS----EDPVPV-KRHSDAVFTDNYTR 136
           A G+    + K+L QLSA K+L+SL+ + V  ++     +D  P+ KRHSD +FTD+Y+R
Sbjct: 84  AHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSR 143

Query: 137 LRKQMAVKKYLNSILNGKR 155
            RKQMAVKKYL ++L GKR
Sbjct: 144 YRKQMAVKKYLAAVL-GKR 161



 Score = 40.8 bits (94), Expect = 6e-04
 Identities = 15/36 (41%), Positives = 25/36 (69%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNI 115
           RH+DG+FT  +S+   Q++ KKYL +++GKR    +
Sbjct: 131 RHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRV 166


>gi|4503945 glucagon preproprotein [Homo sapiens]
          Length = 180

 Score = 53.1 bits (126), Expect = 1e-07
 Identities = 35/122 (28%), Positives = 65/122 (53%), Gaps = 9/122 (7%)

Query: 51  QVSLKEDIDMLQNALAENDTPYYD---VSRNARHADGVFTSDFSKLLGQLSAKKYLESLM 107
           Q SL++  +  ++  A    P  D   ++ + RH+ G FTSD+SK L    A+ +++ LM
Sbjct: 20  QRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLM 79

Query: 108 G-KRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPE 166
             KR  +NI++     +RH++  FT + +   +  A K+++  ++ G+        DFPE
Sbjct: 80  NTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRR-----DFPE 134

Query: 167 EL 168
           E+
Sbjct: 135 EV 136



 Score = 43.9 bits (102), Expect = 7e-05
 Identities = 24/79 (30%), Positives = 42/79 (53%), Gaps = 4/79 (5%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPV----KRHSDAVFTDNYT 135
           RHA+G FTSD S  L   +AK+++  L+  R   +  E+   V    +RH+D  F+D   
Sbjct: 97  RHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMN 156

Query: 136 RLRKQMAVKKYLNSILNGK 154
            +   +A + ++N ++  K
Sbjct: 157 TILDNLAARDFINWLIQTK 175



 Score = 28.1 bits (61), Expect = 3.8
 Identities = 10/33 (30%), Positives = 22/33 (66%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVS 112
           RHADG F+ + + +L  L+A+ ++  L+  +++
Sbjct: 145 RHADGSFSDEMNTILDNLAARDFINWLIQTKIT 177


>gi|11034841 growth hormone releasing hormone preproprotein [Homo
           sapiens]
          Length = 108

 Score = 43.5 bits (101), Expect = 9e-05
 Identities = 27/86 (31%), Positives = 50/86 (58%), Gaps = 8/86 (9%)

Query: 77  RNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVK--RHSDAVFTDNY 134
           R  R+AD +FT+ + K+LGQLSA+K L+ +M ++   +  E     +  R  D+++ +  
Sbjct: 28  RMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARLGRQVDSMWAE-- 85

Query: 135 TRLRKQMAVKKYLNSIL-NGKRSSEG 159
              +KQM ++  L ++L    R+S+G
Sbjct: 86  ---QKQMELESILVALLQKHSRNSQG 108



 Score = 32.0 bits (71), Expect = 0.26
 Identities = 14/52 (26%), Positives = 33/52 (63%), Gaps = 3/52 (5%)

Query: 112 SSNISEDP---VPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGE 160
           SS+ S  P   + ++R++DA+FT++Y ++  Q++ +K L  I++ ++    +
Sbjct: 16  SSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQ 67


>gi|11345450 secretin preproprotein [Homo sapiens]
          Length = 121

 Score = 33.5 bits (75), Expect = 0.091
 Identities = 15/34 (44%), Positives = 22/34 (64%)

Query: 77  RNARHADGVFTSDFSKLLGQLSAKKYLESLMGKR 110
           R  RH+DG FTS+ S+L      ++ L+ L+GKR
Sbjct: 24  RARRHSDGTFTSELSRLREGARLQRLLQGLVGKR 57



 Score = 31.6 bits (70), Expect = 0.34
 Identities = 15/40 (37%), Positives = 24/40 (60%), Gaps = 1/40 (2%)

Query: 119 PVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSE 158
           P   +RHSD  FT   +RLR+   +++ L  ++ GKRS +
Sbjct: 22  PPRARRHSDGTFTSELSRLREGARLQRLLQGLV-GKRSEQ 60


>gi|110349721 titin isoform novex-3 [Homo sapiens]
          Length = 5604

 Score = 29.6 bits (65), Expect = 1.3
 Identities = 26/114 (22%), Positives = 49/114 (42%), Gaps = 14/114 (12%)

Query: 69   DTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYL-----ESLMGKRVSSNISEDPVPV- 122
            DT   +++      +G +T   S  +GQ+S+   L     ES++ +R+   I  +   + 
Sbjct: 3397 DTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELF 3456

Query: 123  --------KRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEEL 168
                    +R +   F+D+     K MA K+Y + I +     E   P F ++L
Sbjct: 3457 SEGESEHSERDTRDAFSDSEDIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKL 3510


>gi|148727368 bromodomain and PHD finger containing, 3 [Homo
           sapiens]
          Length = 1205

 Score = 29.3 bits (64), Expect = 1.7
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 4/67 (5%)

Query: 56  EDIDM-LQNALAENDTPYYDVSRNARHADG---VFTSDFSKLLGQLSAKKYLESLMGKRV 111
           ED+D  ++  + E D  + D+    R  DG   V    F  L+ +L  + YLES      
Sbjct: 146 EDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQ 205

Query: 112 SSNISED 118
            S I ED
Sbjct: 206 QSLIDED 212


>gi|7657269 PDS5, regulator of cohesion maintenance, homolog B [Homo
            sapiens]
          Length = 1447

 Score = 28.1 bits (61), Expect = 3.8
 Identities = 19/77 (24%), Positives = 32/77 (41%)

Query: 91   SKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSI 150
            S L G+ S K+    L+   +         PV    + +  D+ T+L ++   K    S 
Sbjct: 1191 SPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEKLGMDDLTKLVQEQKPKGSQRSR 1250

Query: 151  LNGKRSSEGESPDFPEE 167
              G  +SE +   +PEE
Sbjct: 1251 KRGHTASESDEQQWPEE 1267


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 28.1 bits (61), Expect = 3.8
 Identities = 21/123 (17%), Positives = 54/123 (43%), Gaps = 12/123 (9%)

Query: 50   DQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLL---------GQLSAK 100
            + +S +++I+M Q  +   ++  ++  ++  H + +   + + L           Q   K
Sbjct: 881  NHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK 940

Query: 101  KYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGE 160
            K  E L   ++    +ED     + ++   T   ++   +++V    N++LN K  +E +
Sbjct: 941  KCFEDL---KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 997

Query: 161  SPD 163
            S +
Sbjct: 998  SKE 1000


>gi|23308597 adenomatosis polyposis coli down-regulated 1 [Homo
           sapiens]
          Length = 514

 Score = 27.7 bits (60), Expect = 5.0
 Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 2/29 (6%)

Query: 139 KQMAVKKYLNSILNGKRSSEGESPDFPEE 167
           +Q A  +YL  + NG+R S+G SPD PE+
Sbjct: 428 EQDARGRYL--LFNGQRPSDGSSPDRPEK 454


>gi|110349786 Alstrom syndrome 1 [Homo sapiens]
          Length = 4169

 Score = 27.3 bits (59), Expect = 6.5
 Identities = 26/131 (19%), Positives = 51/131 (38%), Gaps = 14/131 (10%)

Query: 42  PFEGANEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKK 101
           P     + DQVS+    D+    +A   + ++D +R+           + +   Q  + K
Sbjct: 358 PENNLADKDQVSVATSFDITDENIATKRSDHFDAARS-----------YGQYWTQEDSSK 406

Query: 102 YLESLMGKRVSSNISEDPVPVK--RHSDAVFTDNYTRL-RKQMAVKKYLNSILNGKRSSE 158
             E+ + K +   +  D + +     +  V ++    L RK     +Y +S L   R S 
Sbjct: 407 QAETYLTKGLQGKVESDVITLDGLNENAVVCSERVAELQRKPTRESEYHSSDLRMLRMSP 466

Query: 159 GESPDFPEELE 169
              P  P+ L+
Sbjct: 467 DTVPKAPKHLK 477


>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
           sapiens]
          Length = 1907

 Score = 27.3 bits (59), Expect = 6.5
 Identities = 15/57 (26%), Positives = 30/57 (52%), Gaps = 3/57 (5%)

Query: 111 VSSNISEDPVPVKRHS---DAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDF 164
           +S     +P PV+ +S   D+VF++N   L++Q   +K+ +   +    ++GE   F
Sbjct: 171 LSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASF 227


>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
          Length = 771

 Score = 27.3 bits (59), Expect = 6.5
 Identities = 12/30 (40%), Positives = 19/30 (63%)

Query: 93  LLGQLSAKKYLESLMGKRVSSNISEDPVPV 122
           L+G LS+ K  ES  G R+  ++SE+P  +
Sbjct: 502 LVGHLSSSKSRESSPGPRLGKDLSEEPFDI 531


>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
           sapiens]
          Length = 974

 Score = 27.3 bits (59), Expect = 6.5
 Identities = 12/30 (40%), Positives = 19/30 (63%)

Query: 93  LLGQLSAKKYLESLMGKRVSSNISEDPVPV 122
           L+G LS+ K  ES  G R+  ++SE+P  +
Sbjct: 705 LVGHLSSSKSRESSPGPRLGKDLSEEPFDI 734


>gi|157388929 epsin 3 [Homo sapiens]
          Length = 632

 Score = 27.3 bits (59), Expect = 6.5
 Identities = 15/52 (28%), Positives = 25/52 (48%)

Query: 76  SRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSD 127
           S N+  +   +TSD  +   Q S ++ L+  +   +S   +E PVP   H D
Sbjct: 185 SYNSSSSSPRYTSDLEQARPQTSGEEELQLQLALAMSREEAEKPVPPASHRD 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,832,294
Number of Sequences: 37866
Number of extensions: 222415
Number of successful extensions: 471
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 442
Number of HSP's gapped (non-prelim): 24
length of query: 170
length of database: 18,247,518
effective HSP length: 95
effective length of query: 75
effective length of database: 14,650,248
effective search space: 1098768600
effective search space used: 1098768600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.