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Search of human proteins with 4507461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
(160 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap... 332 8e-92
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s... 326 6e-90
gi|4502461 betacellulin [Homo sapiens] 78 4e-15
gi|29568105 transmembrane protein with EGF-like and two follista... 61 5e-10
gi|12383051 transmembrane protein with EGF-like and two follista... 59 2e-09
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 54 7e-08
gi|61806622 epithelial mitogen [Homo sapiens] 53 1e-07
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens] 52 3e-07
gi|4557567 epiregulin preproprotein [Homo sapiens] 51 5e-07
gi|4502199 amphiregulin preproprotein [Homo sapiens] 44 6e-05
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens] 44 6e-05
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 43 1e-04
gi|20070380 neuregulin 4 [Homo sapiens] 41 4e-04
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 41 5e-04
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 41 5e-04
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 41 5e-04
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 40 7e-04
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 40 7e-04
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 40 9e-04
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 37 0.006
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 37 0.007
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 37 0.009
gi|93102379 low density lipoprotein-related protein 1B precursor... 35 0.021
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 35 0.036
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 35 0.036
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 34 0.047
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 34 0.047
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 34 0.047
gi|66730481 neuregulin 3 [Homo sapiens] 34 0.061
gi|134244285 Notch homolog 3 [Homo sapiens] 34 0.061
>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
Length = 160
Score = 332 bits (851), Expect = 8e-92
Identities = 160/160 (100%), Positives = 160/160 (100%)
Query: 1 MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC 60
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
Sbjct: 1 MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC 60
Query: 61 RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL 120
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
Sbjct: 61 RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL 120
Query: 121 IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV 160
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
Sbjct: 121 IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV 160
>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
sapiens]
Length = 159
Score = 326 bits (835), Expect = 6e-90
Identities = 159/160 (99%), Positives = 159/160 (99%), Gaps = 1/160 (0%)
Query: 1 MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC 60
MVPSAGQLALFALGIVLAACQALENSTSPLS DPPVAAAVVSHFNDCPDSHTQFCFHGTC
Sbjct: 1 MVPSAGQLALFALGIVLAACQALENSTSPLS-DPPVAAAVVSHFNDCPDSHTQFCFHGTC 59
Query: 61 RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL 120
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
Sbjct: 60 RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL 119
Query: 121 IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV 160
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
Sbjct: 120 IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV 159
>gi|4502461 betacellulin [Homo sapiens]
Length = 178
Score = 77.8 bits (190), Expect = 4e-15
Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 15/135 (11%)
Query: 8 LALFALGIVLAACQALE-NST-SP-----LSADPPVAAAVVS-------HFNDCPDSHTQ 53
L ALG+V+ C + NST SP L DP A + HF+ CP +
Sbjct: 16 LLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKH 75
Query: 54 FCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAV 113
+C G CRF+V E P+CVC GY+GARCE DL + + + + L+ V +V + +
Sbjct: 76 YCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLF-YLRGDRGQILVICLIAVMVVFIIL 134
Query: 114 LIITCVLIHCCQVRK 128
+I C H + R+
Sbjct: 135 VIGVCTCCHPLRKRR 149
>gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
Length = 380
Score = 60.8 bits (146), Expect = 5e-10
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 47 CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAITALV 104
CP++ +C HG C F+ K +C C SGY G CE D +L VV + QK +
Sbjct: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAA 334
Query: 105 VVSIVALAVL--IITCVLIHC 123
++ V +A++ I+ C+ C
Sbjct: 335 IIGAVQIAIIVAIVMCITRKC 355
>gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
Length = 374
Score = 58.5 bits (140), Expect = 2e-09
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 43 HFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAI 100
H CP+ + FC HG C + +P+C C +GY G CE D +L VV + Q +
Sbjct: 261 HHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYV 320
Query: 101 TALVVVSIVALAVLIITCVLIHC 123
V+ + +AV+ CV++ C
Sbjct: 321 LIAAVIGTIQIAVI---CVVVLC 340
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 53.5 bits (127), Expect = 7e-08
Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 11/98 (11%)
Query: 29 PLSADPPVAAAVVSHFN------DCPDSHTQFCFH-GTCRFLVQEDKPACVCHSGYVGAR 81
P S PP H++ +CP SH +C H G C ++ DK AC C GY+G R
Sbjct: 952 PDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGER 1011
Query: 82 CEHADL----LAVVAASQKKQAITALVVVSIVALAVLI 115
C++ DL L Q+++ I V V ++ + +L+
Sbjct: 1012 CQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLL 1049
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 53.1 bits (126), Expect = 1e-07
Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 6/85 (7%)
Query: 47 CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVV 106
C + H +C +G C F + +K C C +GY G RCEH L + S +K +
Sbjct: 51 CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEK------YIA 104
Query: 107 SIVALAVLIITCVLIHCCQVRKHCE 131
+ + +L+ ++I C +RK E
Sbjct: 105 IGIGVGLLLSGFLVIFYCYIRKRYE 129
>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
Length = 208
Score = 51.6 bits (122), Expect = 3e-07
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 47 CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVV 106
C + FC HG C+++ + P+C+CH GY G RC H L V T L VV
Sbjct: 108 CLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERC-HGLSLPVENRLYTYDHTTILAVV 166
Query: 107 SIVALAVLIITCV 119
++V +V ++ V
Sbjct: 167 AVVLSSVCLLVIV 179
>gi|4557567 epiregulin preproprotein [Homo sapiens]
Length = 169
Score = 50.8 bits (120), Expect = 5e-07
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 16 VLAAC---QALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACV 72
V+ +C ++ +N T+ + + A VS C +C HG C +LV + C
Sbjct: 35 VIPSCIPGESSDNCTALVQTEDNPRVAQVS-ITKCSSDMNGYCLHGQCIYLVDMSQNYCR 93
Query: 73 CHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAV 113
C GY G RCEH L S++ A+T ++++ + V
Sbjct: 94 CEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVV 134
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 43.9 bits (102), Expect = 6e-05
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 6/86 (6%)
Query: 45 NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL--AVVAASQKKQAITA 102
N C FC HG C+++ + C C Y G RC + +++ +S K A+ A
Sbjct: 144 NPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAA 203
Query: 103 LVVVSIVALAVLIITCVLIHCCQVRK 128
+ ++ +I+T V + Q+R+
Sbjct: 204 IAAF----MSAVILTAVAVITVQLRR 225
>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
Length = 252
Score = 43.9 bits (102), Expect = 6e-05
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 6/86 (6%)
Query: 45 NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL--AVVAASQKKQAITA 102
N C FC HG C+++ + C C Y G RC + +++ +S K A+ A
Sbjct: 144 NPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAA 203
Query: 103 LVVVSIVALAVLIITCVLIHCCQVRK 128
+ ++ +I+T V + Q+R+
Sbjct: 204 IAAF----MSAVILTAVAVITVQLRR 225
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 42.7 bits (99), Expect = 1e-04
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 43 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAIT 101
H C ++ +C +G C ++ ++ +C C GY G RC+ ++ A + Q
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRV 400
Query: 102 ALVVVSIVALAVLIITCVLIHC 123
+ VAL V+ I CV+ +C
Sbjct: 401 LTITGICVALLVVGIVCVVAYC 422
>gi|20070380 neuregulin 4 [Homo sapiens]
Length = 115
Score = 41.2 bits (95), Expect = 4e-04
Identities = 24/79 (30%), Positives = 32/79 (40%), Gaps = 3/79 (3%)
Query: 43 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADL--LAVVAASQKKQA 99
H C SH FC +G C + P C C Y GARCE L ++ S +A
Sbjct: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEA 64
Query: 100 ITALVVVSIVALAVLIITC 118
AL V+ + + C
Sbjct: 65 FVALAVLVTLIIGAFYFLC 83
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 40.8 bits (94), Expect = 5e-04
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 4/97 (4%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C + + G RC++
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
Query: 87 LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ + A + Q + +AL V+ I CV+ +C
Sbjct: 226 MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC 262
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 40.8 bits (94), Expect = 5e-04
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 4/97 (4%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C + + G RC++
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
Query: 87 LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ + A + Q + +AL V+ I CV+ +C
Sbjct: 226 MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC 262
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 40.8 bits (94), Expect = 5e-04
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 4/97 (4%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C + + G RC++
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
Query: 87 LLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ + A + Q + +AL V+ I CV+ +C
Sbjct: 226 MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC 262
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 40.4 bits (93), Expect = 7e-04
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 9/101 (8%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C G+ GARC +
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE-N 224
Query: 87 LLAVVAASQKKQAITALVVVSI----VALAVLIITCVLIHC 123
+ V +K + + V++I +AL V+ I CV+ +C
Sbjct: 225 VPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYC 265
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 40.4 bits (93), Expect = 7e-04
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 9/101 (8%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C G+ GARC +
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE-N 224
Query: 87 LLAVVAASQKKQAITALVVVSI----VALAVLIITCVLIHC 123
+ V +K + + V++I +AL V+ I CV+ +C
Sbjct: 225 VPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYC 265
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 40.0 bits (92), Expect = 9e-04
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 42 SHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHADLLAVVAASQKK 97
SH C + FC +G F+V++ + C C G+ GARC ++ V +K
Sbjct: 23 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE-NVPMKVQNQEKA 81
Query: 98 QAITALVVVSI----VALAVLIITCVLIHC 123
+ + V++I +AL V+ I CV+ +C
Sbjct: 82 EELYQKRVLTITGICIALLVVGIMCVVAYC 111
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 37.4 bits (85), Expect = 0.006
Identities = 21/60 (35%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 55 CFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQA-ITALVVVSIVALAV 113
C HG + + D P C C SGY G CE A + + +T L++V I ALA+
Sbjct: 4383 CMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAI 4442
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 37.0 bits (84), Expect = 0.007
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 7/88 (7%)
Query: 43 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARC-EHADL-LAVVAASQKKQA 99
H C ++ +C +G C ++ ++ +C C +G+ G RC E L L + QK +
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEE 400
Query: 100 ITALVVVSI----VALAVLIITCVLIHC 123
+ V++I VAL V+ I CV+ +C
Sbjct: 401 LYQKRVLTITGICVALLVVGIVCVVAYC 428
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 36.6 bits (83), Expect = 0.009
Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 9/90 (10%)
Query: 43 HFNDCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADLL--------AVVAA 93
H C ++ +C +G C ++ ++ +C C GY G RC+ ++ + A
Sbjct: 341 HARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEA 400
Query: 94 SQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ Q + VAL V+ I CV+ +C
Sbjct: 401 EELYQKRVLTITGICVALLVVGIVCVVAYC 430
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 35.4 bits (80), Expect = 0.021
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 11/81 (13%)
Query: 54 FCFHG-TCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITA---LVVVSIV 109
+C++G TC+ + + P C+C + + G +CE S K I+ ++V +V
Sbjct: 4397 YCYNGGTCQLDPETNVPVCLCSTNWSGTQCERP-----APKSSKSDHISTRSIAIIVPLV 4451
Query: 110 ALAVLIITCV--LIHCCQVRK 128
L LI T V L+ C + R+
Sbjct: 4452 LLVTLITTLVIGLVLCKRKRR 4472
Score = 27.3 bits (59), Expect = 5.7
Identities = 10/31 (32%), Positives = 16/31 (51%)
Query: 54 FCFHGTCRFLVQEDKPACVCHSGYVGARCEH 84
FC +G + ++P C C Y G RC++
Sbjct: 4292 FCQNGGTCIVTAGNQPYCHCQPEYTGDRCQY 4322
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 34.7 bits (78), Expect = 0.036
Identities = 23/105 (21%), Positives = 44/105 (41%), Gaps = 12/105 (11%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C + + G RC++
Sbjct: 145 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 204
Query: 87 L--------LAVVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ + + A + Q + +AL V+ I CV+ +C
Sbjct: 205 MASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC 249
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 34.7 bits (78), Expect = 0.036
Identities = 23/105 (21%), Positives = 44/105 (41%), Gaps = 12/105 (11%)
Query: 31 SADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHAD 86
S+ + SH C + FC +G F+V++ + C C + + G RC++
Sbjct: 166 SSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
Query: 87 L--------LAVVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ + + A + Q + +AL V+ I CV+ +C
Sbjct: 226 MASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC 270
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 34.3 bits (77), Expect = 0.047
Identities = 22/94 (23%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 42 SHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHADL--------LA 89
SH C + FC +G F+V++ + C C + + G RC++ + +
Sbjct: 122 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE 181
Query: 90 VVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ A + Q + +AL V+ I CV+ +C
Sbjct: 182 FMEAEELYQKRVLTITGICIALLVVGIMCVVAYC 215
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 34.3 bits (77), Expect = 0.047
Identities = 22/94 (23%), Positives = 41/94 (43%), Gaps = 12/94 (12%)
Query: 42 SHFNDCPDSHTQFCFHGTCRFLVQE----DKPACVCHSGYVGARCEHADL--------LA 89
SH C + FC +G F+V++ + C C + + G RC++ + +
Sbjct: 139 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIE 198
Query: 90 VVAASQKKQAITALVVVSIVALAVLIITCVLIHC 123
+ A + Q + +AL V+ I CV+ +C
Sbjct: 199 FMEAEELYQKRVLTITGICIALLVVGIMCVVAYC 232
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 34.3 bits (77), Expect = 0.047
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 3/56 (5%)
Query: 33 DPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLL 88
D + A +SH CP + C +G + CVC +G+ G+RCEH+ L
Sbjct: 3834 DLNLTAHGISH---CPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQAL 3886
Score = 28.5 bits (62), Expect = 2.6
Identities = 15/43 (34%), Positives = 19/43 (44%), Gaps = 3/43 (6%)
Query: 47 CPDS---HTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD 86
C DS Q C HG E + C+C G+ G CEH +
Sbjct: 4102 CYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEE 4144
Score = 26.6 bits (57), Expect = 9.8
Identities = 15/38 (39%), Positives = 17/38 (44%), Gaps = 2/38 (5%)
Query: 47 CPDSHTQFCFHGTCRFLVQEDKPAC-VCHSGYVGARCE 83
CP F TC FL + + C C GY G RCE
Sbjct: 816 CPYIDASRRFSDTC-FLDTDGQATCDACAPGYTGRRCE 852
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 33.9 bits (76), Expect = 0.061
Identities = 18/63 (28%), Positives = 25/63 (39%), Gaps = 3/63 (4%)
Query: 24 ENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQE---DKPACVCHSGYVGA 80
E STSP + HF C D +C + F+++ C C GY G
Sbjct: 267 ETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGV 326
Query: 81 RCE 83
RC+
Sbjct: 327 RCD 329
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 33.9 bits (76), Expect = 0.061
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 3/40 (7%)
Query: 46 DCPDSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCEH 84
D PD CF+G TC V +C+C GY GA C+H
Sbjct: 924 DLPDCSPSSCFNGGTCVDGVNSF--SCLCRPGYTGAHCQH 961
Score = 30.0 bits (66), Expect = 0.88
Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 9/61 (14%)
Query: 30 LSADPPVAAAVVSHFN--DCP-----DSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARC 82
L + PP V+ N DC DS + +GTC LV + C C GY G RC
Sbjct: 1145 LCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFR--CTCPPGYTGLRC 1202
Query: 83 E 83
E
Sbjct: 1203 E 1203
Score = 28.5 bits (62), Expect = 2.6
Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 5/41 (12%)
Query: 48 PDSHTQFCFHGTCRFLVQEDKPA---CVCHSGYVGARCEHA 85
P SH C H C + D P CVC G+ G RC +
Sbjct: 694 PPSHP--CAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQS 732
Score = 28.1 bits (61), Expect = 3.4
Identities = 16/40 (40%), Positives = 19/40 (47%), Gaps = 7/40 (17%)
Query: 45 NDC-PDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCE 83
+DC PD C HG C + +C C GY G RCE
Sbjct: 547 DDCSPDP----CHHGRCVDGIASF--SCACAPGYTGTRCE 580
Score = 27.3 bits (59), Expect = 5.7
Identities = 20/66 (30%), Positives = 27/66 (40%), Gaps = 8/66 (12%)
Query: 28 SPLSADPPVAAAVVSHFNDCPDSHTQFCFHGT-------CRFLVQEDKPACVCHSGYVGA 80
SP PPV A + P + C G+ C L + AC+C G+VG
Sbjct: 16 SPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREA-ACLCPPGWVGE 74
Query: 81 RCEHAD 86
RC+ D
Sbjct: 75 RCQLED 80
Score = 27.3 bits (59), Expect = 5.7
Identities = 11/27 (40%), Positives = 13/27 (48%), Gaps = 2/27 (7%)
Query: 57 HGTCRFLVQEDKPACVCHSGYVGARCE 83
HG C L +C CH GY G C+
Sbjct: 823 HGICTNLAGSF--SCTCHGGYTGPSCD 847
Score = 26.6 bits (57), Expect = 9.8
Identities = 16/36 (44%), Positives = 18/36 (50%), Gaps = 3/36 (8%)
Query: 49 DSHTQFCFHG-TCRFLVQEDKPACVCHSGYVGARCE 83
+ +Q C HG C LV DK C C SG G CE
Sbjct: 585 ECRSQPCRHGGKCLDLV--DKYLCRCPSGTTGVNCE 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.134 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,205,039
Number of Sequences: 37866
Number of extensions: 248905
Number of successful extensions: 1600
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 1219
Number of HSP's gapped (non-prelim): 442
length of query: 160
length of database: 18,247,518
effective HSP length: 94
effective length of query: 66
effective length of database: 14,688,114
effective search space: 969415524
effective search space used: 969415524
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.